Cocrystallization methods

Abstract

Methods for preparing cocrystals wherein solutions of active agents in suitable liquids are combined with solutions of guests, both with and without suitable liquids, in an interface region are described herein. Methods for analyzing the cocrystals are also described.

Description

Cocrystals are crystals that contain two or more non-identical molecules. Examples of cocrystals may be found in the Cambridge Structural Database. Examples of cocrystals may also be found at Etter, Margaret C., and Daniel A. Adsmond (1990) “The use of cocrystallization as a method of studying hydrogen bond preferences of 2-aminopyridine” J. Chem. Soc., Chem. Commun. 1990 589-59 1, Etter, Margaret C., John C. MacDonald, and Joel Bernstein (1990a) “Graph-set analysis of hydrogen-bond patterns in organic crystals” Acta Crystallogr., Sect. B, Struct. Sci. B46 256-262, Etter, Margaret C., Zofia Urba{umlaut over (n)}czyk-Lipkowska, Mohammad Zia-Ebrahimi, and Thomas W. Panunto (1990b) “Hydrogen bond directed cocrystallization and molecular recognition properties of diarylureas” J. Am. Chem. Soc. 112 8415-8426, which are incorporated herein by reference in their entireties. The following articles are also incorporated herein by reference in their entireties: Carl Henrik Görbotz and Hans-Petter Hersieth, 2000, “On the inclusion of solvent molecules in the crystal structures of organic compounds” Acta Cryst. (2000), B56, 625-534; and V. S. Senthil Kumar, Ashwini Nangia, Amy K. Katz and H. L. Carrell, 2002, “Molecular Complexes of Some Mono- and Dicarboxylic Acids with trans-1,4,-Dithiane-1,4-dioxide” American Chemical Society, Crystal Growth & Design, Vol. 2, No. 4, 2002.

By cocrystallizing an active agent with a guest, one can create new solid state phases which may have improved properties over existing solid state phases of that active agent. For example, new drug formulations comprising cocrystals of active pharmaceutical ingredients (APIs) with pharmaceutically acceptable guests may have superior properties over existing drug formulations. The active agent and guest will vary depending on the industry. For example, in the pharmaceutical field, the active agent may be an API, and the other component of the cocrystal (the guest) must be a pharmaceutically acceptable compound (which could also be an API). Active agents and guests may also include nutraceuticals, agricultural chemicals, pigments, dyes, explosives, polymer additives, lubricant additives, photographic chemicals, and structural and electronic materials.

The methods of the disclosure may be employed to generate a wide variety of cocrystals of active agents and guests. For example, the methods of the disclosure may be used to generate cocrystals of a salt of an active agent, such as a salt of an active pharmaceutical ingredient, with a neutral guest. Alternatively, a cocrystal of a neutral or zwitterionic active agent (or a salt of an active agent) may be generated with a guest salt, which includes a positive ion and a negative ion of its own. Where the active agent is provided in a salt, it may be positively or negatively charged and have a negative or positive counterion.

Physical properties of active agents, or their salts, may be modified by forming a cocrystal. Such properties include melting point, density, hygroscopicity, crystal morphology, loading volume, compressibility, and shelf life. Furthermore, other properties such as bioavailability, toxicity, taste, physical stability, chemical stability, production costs, and manufacturing method may be modified by using a cocrystal rather than the active agent alone, or as a salt.

An active agent can be screened for possible cocrystals where polymorphic forms, hydrates, or solvates are especially problematic. For example, a neutral compound that can only be isolated as amorphous material could be cocrystallized. Forming a cocrystal may up-grade the performance of a drug formulation of an active pharmaceutical ingredient by, for example, changing physical properties identified earlier.

A cocrystal can be used to isolate or purify a compound during manufacturing. If it is desirable to identify all of the solid state phases of an active pharmaceutical ingredient, then cocrystallization may be particularly desirable.

One method of preparing cocrystals involves combining melts of active agents and guests using the Kofler contact method. In a typical Kofler experiment, an active agent is heated to its melting point and then combined, in the melt state with a guest, which is also in the form of a melt. For example, the two melts are placed under a cover slip which then causes the two melts to combine and interact with one another at the interface region of where the two melts contact each other. Sometimes paraffin oil or silicon oil, which are oils wherein the active agents are insoluble, are used to help mobilize either the active agent of the guest. In these methods, it is not possible to prepare cocrystals of compounds which decompose prior to melting. In other circumstances, it is inconvenient or difficult to work with melts at high temperatures. In some instances and on some equipment, high temperatures such as those greater than about 200° C. may be inconvenient to use. Therefore, it would be advantageous to have a method wherein one could prepare cocrystals of active agents and guests which would not require heating to temperatures that either caused the active agent to decompose, that were above about 200° C., or both.

The present disclosure describes methods for screening cocrystals of active agents and guests comprising the steps of contacting an active agent with a suitable liquid to form an active-agent solution; contacting the active-agent solution with a guest solution to form an interface region mixture of the solutions; and solidifying the solution mixture to form a solid; and analyzing the solid to detect the presence of cocrystals. The present disclosure further describes methods of preparing cocrystals of active agents and guests comprising the steps of contacting the active agent with a suitable liquid to form an active-agent solution; contacting the active-agent solution with a guest solution to form a mixture of solutions in an interface region; and solidifying the solution mixture in the interface region to form a cocrystal.

The present disclosure describes methods for screening cocrystals of active agents and guests using suitable liquids. By screening, what is meant is determining whether an active agent and a guest form a cocrystal under the methods described herein. In one embodiment of the disclosure, an active agent is contacted with a suitable liquid to form a composition. The active-agent/suitable liquid composition is then heated until dissolution occurs.

The solution of the active agent and the suitable liquid is combined either with a solution containing the guest alone, which would be in the form of a melt, or a solution containing the guest and the same or a different suitable liquid than that in the active-agent solution. The solutions are combined by allowing boundaries of the two solutions to come in contact with one another at the interface region between the two solutions. Mixing occurs in the interface region but not outside of it. Thus, on the active agent side of the interface, there is substantially no guest beyond the interface and, likewise, on the guest side of the interface, there is substantially no active agent beyond the interface. Where the solutions mix in the interface region, there is a gradient of concentrations ranging from pure active agent in solution to pure guest in solution with a range of concentrations in between.

BRIEF DESCRIPTION OF DRAWINGS

FIG. 1 is a schematic representation of one embodiment of the invention showing an active agent solution in contact with a guest solution in an interface region.

FIG. 2 is a series of micrographs showing cocrystal screening of glutaric acid and compound 1 of Example 1.

FIG. 1 illustrates an embodiment of the disclosure. In that figure, the active agent solution side has been combined with the guest solution side in the interface region. Both solutions were deposited on a slide and coverslip was placed on the slide to allow for mixing in the interface region. The figure illustrates the formation of a cocrystal which may have occurred, for instance, by cooling. In a typical experiment, the cooling procedure also solidifies the active agent solution side and the guest solution side such that much of what was previously in solution has solidified. By heat cycling the slide, it can be determined whether the solid in the center is indeed a cocrystal. If the solid is compound A, then heating the slide will show a liquid region in the interface region. Likewise, if the solid is compound B, then heating the slide will also result in a liquid in the interface region. If, however, the solid is a cocrystal of the active agent and the guest, then it will have melting properties that differ from either the active agent alone or the guest alone. Thus, heat cycling a cocrystal will yield at some points in the heat cycling a liquid on one side of the solid and at other points, a liquid on the other side of the solid.

Once the two solutions are combined into a mixture, a solidification is allowed to occur in the interface region. In one embodiment of the disclosure, solidification in the interface region occurs by cooling the interface region until a solid forms. The solid typically contains a cocrystal of the active agent and guest, the active agent alone, the guest alone, or a combination thereof. The presence of a cocrystal in the solid may be confirmed by observing eutectic formation in the interface region. Generally, a eutectic is present when the composition of a mixture of two molecular species has a minimum melting point that is lower than the melting points of the two individual molecular species.

One can determine whether eutectics occur by heat cycling the solid in the interface region. In the interface region, the mixture of the active agent and the guest causes a melting point depression effect. When the temperature is raised, the solids in the interface region melt first due to the depressed melting point. If no cocrystal has formed, then a single clear solution will be observed in the interface region. This liquid is evidence of a eutectic. If, on the other hand, a cocrystal has formed, then two separate portions of the interface regions containing eutectics will be observed, possibly at different temperatures and, therefore, at different times during a heat cycling experiment. One eutectic-containing interface region will form between the cocrystal and the active agent side and another will form in between the cocrystal and the guest side. One way to observe cocrystal presence is to view the interface region through an optical microscope equipped with polarizing filters. In such a microscope, the cocrystal will appear bright and the eutectic regions, which will only contain liquid, will appear dark.

To further analyze the cocrystal, one may use any suitable analytical technique for analyzing crystalline solids such as x-ray powder diffraction, single-crystal x-ray diffraction, Raman spectroscopy including Raman microscopy, solid-state NMR spectroscopy, and IR spectroscopy. Other analytical methods such as melting point determination, thermal gravimetric analysis, DSC, elemental analysis, and others may also provide useful information about the cocrystal. Once the cocrystal forms, a seed of the cocrystal may be used to assist in the nucleation of the cocrystal in other solidification experiments.

A suitable liquid of the disclosure is one which when combined with an active agent and heated lowers the melting point of the active agent, prevents the active agent from decomposing when heated to a temperature which, in the absence of the suitable liquid the active agent would at least partially decompose, or both.

Many active agents have relatively high melting points. For example, agents with a melting temperature of greater than about 200° C. are difficult to work with or melt on many experimental instruments. In addition, many active agents are prone to decompose when heated prior to reaching their melting point. Further, the greater the difference between the melting point values of active agents and guests, the greater the difficulty in observing eutectic formation during a Kofler contact method experiment.

A suitable liquid of the disclosure, when combined with an active agent forms a solution at a lower temperature than that of the melting point of the active agent. By varying the amount of suitable liquid used, one can also vary the temperature at which dissolution of the active agent occurs.

When selecting suitable liquids for the methods of the disclosure, it has been observed that different suitable liquids may have different properties with respect to any given active agent. One of the factors involved in selecting a suitable liquid is the temperature at which dissolution occurs. For example, it is generally inconvenient to perform the cocrystal screening experiments of the invention at temperature above about 200° C. due, for instance, to the evolution of potentially toxic fumes at such elevated temperatures. Thus, it is often valuable to have a suitable liquid/active agent combination wherein dissolution occurs at a temperature less than about 200° C. Other factors when selecting a suitable liquid for a particular active agent is the ability of the active agent to nucleate in the suitable liquid, the growth rate of crystals of the active agent in the suitable liquid, and the quality of crystals that may grow from the suitable liquid.

The nucleation and crystallization behavior of the active agent, the guest, or both, may be affected by which suitable liquid is employed. A factor that may affect nucleation and crystallization includes the ability of the suitable liquid to accept or donate hydrogen bonds. Thus, a number of suitable liquids may be tested in any given screen for cocrystals in order to determine which promotes the preferred crystallization behavior of the active agent or guest.

Suitable liquids of the disclosure are typically organic compounds that are liquids or oils at room temperature. In one embodiment, suitable liquids have low toxicity in order to minimize the biological effects of volatile fumes that may be created during the melting process.

Examples of suitable liquids of the disclosure include but are not limited to benzyl alcohol

• • phenethyl alcohol
  • ethyl butyrate ethyl acetoacetate
  • methyl benzoate
  • ethyl benzoate
  • anisole
  • cyclopentanone
  • ethyl isovalerate
  • cymene
  • p-anisaldehyde
  • 1,1-diethoxyethane
  • methyl propionate
  • 2′-hydroxyacetophenone
  • ethyl cinnamate
  • ethyl phenylacetate
  • ethyl salicylate
  • gamma-valerolactone
  • phenylethanal
  • 2-methoxy-4-methylphenol
  • 3-phenylpropionaldehyde
  • 1-phenylethyl propionate
  • ethyl 4-methoxybenzoate
  • salicylylaldehyde
  • 2,2′-oxybisethanol
  • methyl salicylate
  • p-anisaldehyde
  • 2′-hydroxyacetophenone
  • p-methylacetophenone
  • ethylene glycol
  • dimethylsulfoxide
  • dimethyl formamide
  • octyl alcohol
  • nitro-benzene
  • benzonitrile

The active agent is the molecule whose activity is desirable. One or more active agents may be employed in a cocrystal, according to the methods of the disclosure.

Active agents may include APIs. Examples of APIs (or salts thereof) may be found, for instance, in the FDA Orange Book. Other examples of active agents include nutraceuticals, agricultural chemicals, pigments, dyes, explosives, polymer additives, lubricant additives, photographic chemicals, or structural and electronic materials.

The active agent may be provided as a salt. One or more salts may be employed in a cocrystal, according to the methods of the disclosure. The salt may be prepared from the active agent or obtained from a commercial source. In the pharmaceutical industry, for instance, hydrochloride salts of active pharmaceutical ingredients, especially of amine APIs, are commonly used. The present cocrystals may comprise salts other than chloride salts. Examples of salts include, but are not limited to, those formed from the following acids:

• • sulfuric acid
  • phosphoric acid
  • hydrobromic acid
  • nitric acid
  • pyrophosphoric acid
  • methanesulfonic acid
  • thiocyanic acid
  • naphthalene-2-sulfonic acid
  • 1,5-naphthalenedisulfonic acid
  • cyclamic acid
  • p-toluenesulfonic acid
  • maleic acid
  • L-aspartic acid
  • 2-hydroxy-ethanesulfonic acid
  • glycerophosphoric acid
  • ethanesulfonic acid
  • hydroiodic acid

In other aspects of the disclosure, the active agent is an anion of a salt. Cations (including cations as well as compounds that can form cations) for preparing active agents as salts include, but are not limited to, aluminum, ammonium, benzathine, calcium, diethanolamine, diethylamine, dimeglumine, disodium, lithium, lysine, magnesium, meglumine, potassium, sodium, and zinc. Among the preferred anions are acetate, L-aspartate, besylate, bicarbonate, carbonate, D-camsylate, L-camsylate, citrate, edisylate, fumarate, gluconate, hydrobromide/bromide, hydrochloride/chloride, D-lactate, L-lactate, DL-lactate, D,L-malate, L-malate, mesylate, pamoate, phosphate, succinate, sulfate, D-tartrate, L-tartrate, D,L-tartrate, meso-tartrate, benzoate, gluceptate, D-glucuronate, hybenzate, isethionate, malonate, methylsufate, 2-napsylate, nicotinate, nitrate, orotate, stearate, tosylate, acefyllinate, aceturate, aminosalicylate, ascorbate, ascorbate, borate, butyrate, camphorate, camphocarbonate, decanoate, hexanoate, cholate, cypionate, dichloroacetate, edentate, ethyl sulfate, furate, fusidate, galactarate (mucate), galacturonate, gallate, gentisate, glutamate, glutamate, glutarate, glycerophosphate, heptanoate (enanthate), hydroxybenzoate, hippurate, phenylpropionate, iodide, xinafoate, lactobionate, laurate, maleate, mandelate, methanesufonate, myristate, napadisilate, oleate, oxalate, palmitate, picrate, pivalate, propionate, pyrophosphate, salicylate, salicylsulfate, sulfosalicylate, sulfosalicylate, tannate, terephthalate, thiosalicylate, tribrophenate, valerate, valproate, adipate, 4-acetamidobenzoate, camsylate, octanoate, estolate, esylate, glycolate, thiocyanate, and undecylenate.

When a metal cation is employed as a counterion of the active agent, the interaction between the guest of a cocrystal and the cation is not a hydrogen bond but rather is an intermolecular interaction between an electron rich group such as a carbonyl and the metal cation. This interaction is often not as strong as a hydrogen bond, but is still a favorable interaction and thus can contribute to the stabilization of the cocrystal.

When the active agent is a HCl salt, one can cocrystallize the HCl salt with a neutral guest molecule. By doing this one can create solid state phases with specific properties. For instance one can make a solid comprising an active pharmaceutical ingredient having greater or lesser intrinsic solubility and/or a faster or slower dissolution rate, depending on the guest compound that is chosen.

By “guest” what is meant is the component of the cocrystal that is not the active agent of the disclosure. The guest is present in order to form the cocrystal with the active agent. It is contemplated that one or more guests may be employed in a cocrystal, according to any of the techniques of the disclosure. Accordingly, the guest is not required to have an activity of its own, although it may have some activity. In some situations, the guest may have the same activity as or an activity complementary to that of the active agent. The guest may be another active agent. For example, some guests may facilitate the therapeutic effect of an active pharmaceutical ingredient. For pharmaceutical formulations, the guest may be any pharmaceutically acceptable molecule(s) that forms a cocrystal with the API or its salt. The Registry of Toxic Effects of Chemical Substances (RTECS) database is a useful source for toxicology information, and the GRAS list contains about 2500 relevant compounds. Both sources may be used to help identify guests.

The guest may be neutral (such as benzoic acid and succinic acid in the examples below) or ionic (such as sodium benzoate or sodium succinate). Neutral guests are nonionic guests. Ionic guests are compounds or complexes having ionic bonds. General classes of guests include but are not limited to organic bases, organic salts, alcohols, aldehydes, amino acids, sugars, ionic inorganics, aliphatic esters, aliphatic ketones, organic acids, aromatic esters, and aromatic ketones. The guest may be an acid that forms hydrogen bonds with the chloride (or other anion). For example, suitable guests which are acids include (but not are not limited to):

• • ascorbic acid
  • glucoheptonic acid
  • sebacic acid
  • alginic acid
  • cyclamic acid
  • ethane-1,2-disulfonic acid
  • 2-hydroxyethanesulfonic acid
  • 2-oxo-glutaric acid
  • naphthalene-1,5-disulfonic acid
  • nicotinic acid
  • pyroglutamic acid
  • 4-acetamidobenzoic acid

Table 1 sets forth a group of guests of the disclosure. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

TABLE 1
10-camphorsulfonic acid   oleic acid
10-undecylenic acid       o-methylbenzoic acid
1-hydroxy-2-napthoic acid orotic acid
2,4-dihydroxybenzoic acid orthoboric acid
2,5-dihydroxybenzoic acid o-toluic acid
2-aminopropionic acid     p-acetamidobenzoic acid
2-ethylbutyrinc acid      palmitic acid
2-furancarboxylic acid    pamoic acid
2-mercapotobenzoic acid   phenoxyacetic acid
3-methylbutanoic acid     phenylacetic acid
3phenylpropionic acid     phenylalanine
4-aminobenzoic acid       picric acid
4-aminosalicylic acid     pivalic acid
4-hydroxybenzoic acid     proline
adipic acid               p-toluenesulfonic acid
alginic acid              pyroglutamic acid
anisic acid               pyruvic add
arginine                  salicyclic acid
ascorbic acid             sebacic acid
asparagine                serine
aspartic acid             sorbic acid
aspirin                   stearic acid
benzenesulfonic acid      succinic acid
benzoic acid              sulfosalicylic acrid
4-acetamidobenzoic acid   tartaric acid
beta-alanine              terephthalic acid
camphoric acid            thiocyanic acid
camphorsulfonic acid      threonine
carbonic acid             tiglic acid
cholic acid               tryptophan
cinnamic acid             tyrosine
citric acid               valeric acid
cyclamic acid             valine
cyclohexanecarboxylic acid
cyclohexylacetic acid
cysteine
diphenylacetic acid
dodecylsulfonic acid
ethane-1,2-disulfonic acid
ethanesulfonic acid
ethanesulfonic acid, 2-hydroxy
ethylenediaminetetraacetic acid
ethylsulfuric acid
fumaric acid
galactaric acid
gallic acid
gentisic acid
glucoheptonic acid
gluconic acid
glutamic Acid
glutamine
glutaric acid
glutaric acid, 2-oxo-
glycine
glycolic acid
hippuric acid
histidine
hydroxypropline
isoleucine
lactobionic acid
lauric acid
leucine
levulinic acid
lysine
maleic acid
malic acid
malonic acid
mandelic acid
m-methoxybenzoic acid
naphthalene-1,5,disulfonic acid
naphthalene-2-sulfonic acid
n-decanoic acid
niacin
nicotinic acid
n-tetradecanoic acid

Table 2 sets forth another group of guests of the disclosure. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

TABLE 2
Name                             CAS #
Potassium bicarbonate            298-14-6
Potassium carbonate              584-08-7
Potassium chloride               7447-40-7
Potassium hydroxide              1310-58-3
Potassium metabisulfite          16731-55-8
Potassium nitrate                7757-79-1
Potassium nitrate                7758-09-0
Potassium permanganate           7722-64-7
Potassium persulfate             7727-21-1
Potassium phosphate, dibasic     2139900
Potassium Phosphate              7778-77-0
Monobasic                        7778-53-2
potassium phosphate, tribasic,
n-hydrate
Potassium sulfate                7778-80-5
Sodium bicarbonate               144-55-8
Sodium bisulfite                 7631-90-5
Sodium borohydride               16940-66-2
Sodium carbonate                 497-19-8
Sodium Carbonate Monohydrate     1486118
Sodium chloride                  7647-14-5
Sodium dithionite                7775-14-6
Sodium fluoride                  7681-49-4
Sodium hexamataphosphate         10124-56-8
Sodium hydroxide                 1310-73-2
Sodium hypochlorite              7681-52-9
Sodium Metabisulfite             7681-57-4
Disodium metasilicate            6834-92-0
sodium monophosphate             7681-53-0
Sodium nitrate                   7631-99-4
Sodium nitrite                   7632-00-0
sodium hydrogen phosphate        7558-79-4
Sodium Phosphate Monobasic       7558-80-7
Sodium Pyrophosphate             7722-88-5
Sodium silicate                  1344-09-8
Sodium Sulfate Decahydrate       7727-73-3
Sodium sulfite                   7757-83-7
Sodium Thiosulfate               10102-17-7
Pentahydrate
Calcium acetate                  5743-26-0
Calcium Carbonate                471-34-1
Calcium Chloride Dihydrate       10035-04-8
Calcium gluconate                299-28-5
calcium hydroxide                1305-62-0
Calcium oxide                    1305-78-8
Calcium phosphate, dibasic       7757-93-9
Calcium Phosphate Monobasic      7758-23-8
Calcium sulfate                  7778-18-9
Magnesium hydroxide              1309-42-8
Magnesium Sulfate                10034-99-8
Heptahydrate
Aluminum                         7429-90-5
Aluminum ammonium sulfate        7784-26-1
Aluminum chloride                7446-70-0
Aluminum hydroxide               21645-51-2
Aluminum potassium sulfate,      7784-24-9
dodecahydrate
Orthoboric acid                  10043-35-3
formaldehyde                     50-00-0
DL-Isoleucine                    443-79-8
(2S,7S)-(−)Cystine               56-89-3
DL-Alanine                       302-72-7
beta-Alanine                     107-95-9
(S)-(+)-Arginine                 74-79-3
(S)-(−)-Cysteine                 52-90-4
DL-Glutamic acid                 617-65-2
Glycine                          56-40-6
(S)-(−)-Histine                  71-00-1
(S)-(+)-Lysine                   56-87-1
DL-Methionine                    59-51-8
DL-Phenlalanine                  150-30-1
(S)-(−)Phenylalanine             63-91-2
D-(+)-Proline                    344-25-2
(S)-(−)-Tryptophan               73-22-3
(S)-(−)-Tyrosine                 60-18-4
Carvone                          99-49-0
Citral                           5392-40-5
Ethyl butyrate                   105-54-4
Isobutyl propionate              540-42-1
Methyl butyrate                  623-42-7
n-Propyl acetate                 109-60-4
Isobutyl formate                 542-55-2
Benzyl acetate                   140-11-4
6-Methyl-5-hepten-2-one          110-93-0
Butyl acetate                    123-86-4
Ethyl acetoacetate               141-97-9
Isopentyl Acetate                123-92-2
Cinnamaldehyde                   104-55-2
Methyl benzoate                  93-58-3
Butyl sulfide                    544-40-1
Ethyl benzoate                   93-89-0
2,4-Hexadienoic acid,            24634-61-5
potassium salt, (E,E)-
Potassium bitartrate             868-14-4
Lauric acid                      143-07-7
Benzyl benzoate                  120-51-4
Picric acid                      88-89-1
Benzoyl peroxide                 94-36-0
Palmitic acid                    57-10-3
Dibutyl phthalate                84-74-2
Stearic acid                     57-11-4
Succinic anhydride               108-30-5
Diethylenetriamine               111-40-0
Diethanolamine                   111-42-2
Benzaldehyde                     100-52-7
Phenethylamine                   64-04-0
Salicylylaldehyde                90-02-8
Sodium benzoate                  532-32-1
Cinnamic acid                    621-82-9
Triethanolamine                  102-71-6
L-(+)-Tartaric Acid              87-69-4
Eugenol                          97-53-0
D-mannitol                       69-65-8
Butyl paraben                    94-26-8
Benzoin                          119-53-9
Diethyl phthalate                84-66-2
Oleic acid                       112-80-1
Sodium lactate                   72-17-3
Indole                           120-72-9
etbyl lactate                    97-64-3
quinoline                        91-22-5
Thymol                           89-83-8
Methyl anthranilate              134-20-3
Methyl salicylate                119-36-8
Diethyl malonate                 105-53-3
Citric acid                      77-92-9
Sodium dodecyl sulfate           151-21-3
Morpholine                       110-91-8
Furfural                         98-01-1
Niacin                           59-67-6
Choline chloride                 67-48-1
L-Menthol                        2216-51-5
Meso-inositol                    87-89-8
ethylenediaminetetraacetic       60-00-4
acid
EDTA, calcium derivative,        62-33-9
disodium salt
Calcium pantothemate             137-08-6
Riboflavin                       83-88-5
Zinc carbonate                   3486-35-9
Amyl alcohol                     71-41-0
Mineral oil                      8012-95-1
Triton(R) X-100                  9002-93-1
Acetaldehyde                     75-07-0
Acetic Acid                      64-19-7
Acetone                          67-64-1
Acetophenone                     98-86-2
4-Aminobenzoic acid              150-13-0
Anisole                          100-66-3
Vitamin C                        50-81-7
Benzoic Acid                     65-85-0
Biphenyl                         92-52-4
2-Methyl-1 propanol              78-83-1
n-Butanol                        71-36-3
n-Butylamine                     109-73-9
ethyl acetate                    141-78-6
Caffeine                         58-08-2
Chloroacetic Acid                79-11-8
Dichloroacetic Acid              79-43-6
Diethylamine                     109-89-7
Ethanol Amine                    141-43-5
n-Butyric Acid                   107-92-6
Ethylenediamine                  107-15-3
Formic acid                      64-18-6
n-Hexanol                        111-27-3
Methanol                         67-56-1
Methyl Acetate                   79-20-9
Methyl 4-hydroxybenzoate         99-76-3
m-Cresol                         108-39-4
p-Cresol                         106-44-5
Phenol                           108-95-2
n-Propanol                       71-23-8
Propionic Acid                   79-09-4
Salicylic acid                   69-72-7
Sucrose                          57-50-1
Vanillin                         121-33-5
Vitamin E                        59-02-9
Potassium citrate, monohydrate   1534146
p-toluenesulfonic acid           6192-52-5
monohydrate
D-(+)-Maltose                    69-79-4
Tetrasodium                      64-02-8
ethylenediaminetetraacetate
Saccharin sodium                 128-44-9
Sodium Acetate Trihydrate        6131-90-4
Quinine sulfate, dihydrate       6119-70-6
Sulfosalicylic acid, dihydrate   5965-83-3
L-(+)-Arginine                   1119-34-2
monohydrochloride
Procaine hydrochloride           51-05-8
Pyridoxine Hydrochloride         58-56-0
Thiamine hydrochloride           67-03-8
Propionaldehyde                  123-38-6
Urea                             57-13-6
2-Propanol                       67-63-0
Pyrrole                          109-97-7
Sodium formate                   141-53-7
Pyrrolidine                      123-75-1
Methyl ethyl ketone              78-93-3
Ethyl formate                    109-94-4
Propylene glycol                 57-55-6
Thiourea                         62-56-6
Ammonium acetate                 631-61-8
Benzene                          71-43-2
Sodium acetate                   127-09-3
Cyclopentanone                   120-92-3
Cyclohexane                      110-82-7
piperidine                       110-89-4
2-Pentanone                      107-87-9
hexane                           110-54-3
Isoamyl Alcohol                  123-51-3
Lactic acid                      50-21-5
2-Ethoxyethanol                  110-80-5
Propionic acid, sodium salt      137-40-6
Potassium acetate                127-08-2
cyclohexyl amine                 108-91-8
methyl methacrylate              80-62-6
methyl isobutyl ketone           108-10-1
Acetic anhydride                 108-24-7
Isopropyl Acetate                108-21-4
2,2′-Oxybisethanol               111-46-6
Benzyl alcohol                   100-51-6
Resorcinol                       108-46-3
2-Butoxy ethanol                 111-76-2
Cumene                           98-82-8
2-Amino-2-(hydroxymethyl)-1,3-   77-86-1
propanediol
Phenethyl alcohol                60-12-8
2-Ethyl-1-hexanol                104-76-7
2-Octanol                        123-96-6
2-(2-Ethoxyethoxy) ethanol       111-90-0
2,6-(Dimethyl-4-heptanone        108-83-8
Benzophenone                     119-61-9
D-(−)-Fructose                   57-48-7
D-Glucose                        50-99-7
D-Ribose                         50-69-1
D-(+)-Xylose                     58-86-6
Pectin sugar                     5328-37-0
D-(+)-Lactose                    63-42-3
Camphene                         79-92-5
Isoquinoline                     119-65-3
2,4-Dimethylphenol               105-67-9
2,5-Dimethylphenol               95-87-4
2,6-Dimethylphenol               576-26-1
Methanesulfonic Acid             75-75-2
o-Methoxybenzoic Acid            579-75-9
Saccharin                        81-07-2
Thiazole                         288-47-1
Trifluoromethanesulfonic Acid    1493-13-6
Trimethylamine                   75-50-3
Coumarin                         91-64-5
Dimethylamine                    124-40-3
Ethyl Alcohol                    64-17-5
Butyl benzyl phthalate           85-68-7
2,6-dimethylpyrazine             108-50-9
taurocholic acid                 81-24-3
geraniol                         106-24-1
linalool                         78-70-6
ethyl isovalerate                108-64-5
ethyl 2-methylbutyrate           7452-79-1
1-octen-3-ol                     3391-86-4
ethyl 2-trans-4-cis-             3025-30-7
decadienoate
Dihydromyrcenol                  18479-58-8
citronellal                      106-23-0
linalyl acetate                  115-95-7
8-mercapto-p-menthan-3-one       38462-22-5
Ammonium citrate                 3012-65-5
Ammonium bicarbonate             1066-33-7
Ammonium chloride                12125-02-9
Ammonium hydroxide               1336-21-6
Ammonium persulfate              7727-54-0
Ammonium phosphate, dibasic      7783-28-0
Ammonium Phosphate               7722-76-1
Monobasic
Ammonium sulfate                 7783-20-2
Ammonium sulfide                 12135-76-1
Hydrazine                        302-01-2
Nitric acid                      7697-37-2
phosphoric acid                  7664-38-2
Phosphorus oxychloride           10025-87-3
Hydriodic acid                   10034-85-2
Hydrobromic acid                 10035-10-6
Huydrochloric acid               7647-01-0
hydrogen peroxide                7722-84-1
Periodic Acid                    10450-60-9
Sulfamic acid                    5329-14-6
Sulfuric acid                    7664-93-9
Sulfurous acid                   7782-99-2
Dexpanthenol                     81-13-0
4-oxoisophorone                  1125-21-9
Copper(II) sulfate               7758-98-7
ferric chloride                  7705-08-0
Ferric oxide                     1309-37-1
ferric sulfate                   10028-22-5
Iron (II) Sulfate Heptahydrate   7782-63-0
Iron                             7439-89-6
Manganese (II) Sulfate           10034-96-5
Monohydrate
Nickel                           7440-02-0
Titanium dioxide                 13463-67-7
Zinc chloride                    7646-85-7
Zinc oxide                       1314-13-2
1,1′-Azobisformamide             123-77-3
1,3-Butanediol                   107-88-0
1-Methylnaphtalene               90-12-0
2,6-Di-tert-Butyl-p-Cresol       128-37-0
2,6-Dimethylpyridine             108-48-5
Disodium                         138-93-2
cyanodithiomidocarbonate
3-Methyl-2-Cyclopentene-2-ol-    80-71-7
one
6-Methylcoumarin                 92-48-8
acetoin                          513-86-0
alpha-Phellandrene               99-83-2
alpha-Terpinene                  99-86-5
Benzenesulfonic Acid             98-11-3
Benzothiazole                    95-16-9
borates, tetrasodium salts       1330-43-4
Butyl butyrate                   109-21-7
Butyl Mercaptan                  109-79-5
Butyraldehyde                    123-72-8
Capasaicin                       404-86-4
Chloromethyl Methyl Ether        107-30-2
Cymene                           99-87-6
Diallyl Disulfide                2179-57-9
Diethylaminoethanol              100-37-8
dimethyldisulfide                624-92-0
Dimethyl Succinate               106-65-0
Dimethyl Sulfate                 77-78-1
Dimethyl Sulfide                 75-18-3
Dipropyl Disulfide               629-19-6
Dipropyl Ketone                  123-19-3
Ethyl Acrylate                   140-88-5
Ethyl Butyl Ketone               106-35-4
Ethyl Propionate                 105-37-3
Furfuryl Alcohol                 98-00-0
gamnma-Butyrolactone             96-48-0
Glutaraldehyde                   111-30-8
gylcerin                         56-81-5
Glycolic Acid                    79-14-1
Isobutyl Acetate                 110-19-0
Isobutyl Isobutyrate             97-85-8
Isobutyraldehyde                 78-84-2
Isoheptanol                      543-49-7
Isophorone                       78-59-1
Isopropyl Mercaptan              75-33-2
Methyl isobutenyl ketone         141-79-7
Methyl n-amyl ketone             110-43-0
methyl acrylate                  96-33-3
Methyl Isobutyrate               547-63-7
Methyl Mercaptan                 74-93-1
N,N-Dimethylethanolamine         108-01-0
n-Butyl Lactate                  138-22-7
n-Hexyl Acetate                  142-92-7
n-Valeraldehyde                  110-62-3
Nitrous Oxide                    10024-97-2
p-Anisaldehyde                   123-11-5
2-Methylcyclohexanone            583-60-8
Octanoic Acid                    124-07-2
Oxalic Acid                      144-62-7
Phenyl ether                     101-84-8
Phenylmercaptan                  108-98-5
Propargyl Alcohol                107-19-7
Propyl paraben                   94-13-3
sec-Butyl Alcohol                78-92-2
Sodium Gluconate                 527-07-1
Sodium Tripolyphosphate          7758-29-4
Tetrahydro-2-furanmethanol       97-99-4
Valeric Acid                     109-52-4
3,4-xylenol                      95-65-8
3-hexanol                        623-37-0
3-methyl-1-pentanol              589-35-5
1,1-diethoxyethane               105-57-7
Aluminum Sulfate                 10043-01-3
ammonium sulfite                 10196-04-0
amyl butyrate                    540-18-1
borneol                          507-70-0
butyl formate                    592-84-7
calcium peroxide                 1305-79-9
n-Hexanoic Acid                  142-62-1
cyclohexyl acetate               622-45-7
diacetyl                         431-03-8
dimethyl carbonate               616-38-6
ethyl butyraldehyde              97-96-1
Ethyl crotonate                  623-70-1
ethyl isobutyrate                97-62-1
ethyl nitrite                    109-95-5
fumaric acid                     110-17-8
hexaldehyde                      66-25-1
isobutyric acid                  79-31-2
methyl isovalerate               556-24-1
methyl propionate                554-12-1
methyl valeraldehyde             123-15-9
nitrosyl chloride                2696-92-6
octafluorocyclobutane            115-25-3
peroxyacetic acid                79-21-0
propyl formate                   110-74-7
propyl mercaptan                 107-03-9
Sodium aluminate                 1302-42-7
sodium chlorite                  7758-19-2
Terephthalic Acid                100-21-0
allyl isothiocyanate             57-06-7
Vitamin B1                       59-43-8
Valproic acid                    99-66-1
Ethoxyquin                       91-53-2
n-Amyl Ethyl Ketone              106-68-3
Nabam                            142-59-6
Sodium sulfide                   1313-82-2
Thiocyanic acid                  463-56-9
2-Methyl-5-(1-methylethenyl)-    2244-16-8
2-cyclohexene-1-one
4-(2,6,6-Trimethyl-2-            127-41-3
cyclohexen-1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-            14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Isoamyl propionate               105-68-0
3-Methylbutanoic acid            503-74-2
L-Menthone                       14073-97-3
4-Ethylphenol                    123-07-9
o-cresol                         95-48-7
dimethyl-Carbamodithioic acid,   128-04-1
sodium salt
Anethole                         104-46-1
Dimethyl terephthalate           120-61-6
propyl gallate                   121-79-9
L-Ascorbic Acid Sodium Salt      134-03-2
4-Hexylresorcinol                136-77-6
Estragole                        140-67-0
L-monosodium glutamate           142-47-2
Malonaldehyde, sodium salt       24382-04-5
Butylated hydroxyanisole         25013-16-5
allyl 3-methylbutyrate           2835-39-4
DL-monosodium glutamate          32221-81-1
3-Acetyl-6-methyl-2,4-           520-45-6
pyrandione
L-Glutamic Acid                  56-86-0
DL-alpha-tocopheryl acetate      58-95-7
D-limonene                       5989-27-5
Calcium Acetate                  62-54-4
Erythorbic Acid Monosodium       6381-77-7
Salt
Ethyl methylphenylglycidate      77-83-8
2,4,6-Trinitro-1,3-dimethyl-5-   81-15-2
tert-butylbenzene
Dimethoxane                      828-00-2
3,5-Di-tert--butyl-4-            88-26-6
hydroxybenzyl alcohol
6-Methylquinoline                91-62-3
alpha-Methylbenzyl alcohol       98-85-1
Nicotinamide                     98-92-0
3,4-Dihydrocoumarin              119-84-6
Geranyl Acetate                  105-87-3
Sodium (2-Ethylhexyl)Alcohol     126-92-1
Sulfate
Cyclohexanol, 5-methyl-2-(1-     89-78-1
methylethyl)-,
(1alpha,2beta,5alpha)-
(+)-Camphor                      464-49-3
(1S)-(−)-alpha-Pinene            7785-26-4
1,3-Dihydroxy-5-methylbenzente   504-15-4
1,5-Naphthalenedisulfonic Acid   1655-29-4
Disodium Salt
1-Hydroxy-2-naphthoic Acid       86-48-6
1-Penten-3-ol                    616-25-1
1-Phenyl-1-propanol              93-54-9
10-Undecylenic Acid              112-38-9
2′-Hydroxyacetophenone           118-93-4
2,4-Dihydroxybenzoic Acid        89-86-1
2-Acetylfuran                    1192-62-7
2-Furancarboxylic Acid           88-14-2
2-Isopropylphenol                88-69-7
2-Ketoglutaric Acid              328-50-7
2-Ketovaline                     759-05-7
2-n-Propylphenol                 644-35-9
2-Naphthalenethiol               91-60-1
2-Phenyl-1-propanol              1123-85-9
3,3′-Thiodipropionic Acid        111-17-1
3,5,5-Trimethylhexanal           5435-64-3
3-Phenyl-1-propanol              122-97-4
3-Phenylpropionic Acid           501-52-0
4-Aminosalicylic Acid            65-49-6
4-Ethoxyphenol                   622-62-8
4-Hydroxybenzoic Acid            99-96-7
4-Phenyl-2-butanol               2344-70-9
4-tert-Octylphenol               140-66-9
Allyl Cinnamate                  1866-31-5
Ally Mercaptan                   870-23-5
alpha-L-Rhamnose                 3615-41-6
Alpha-Terpineol                  98-55-5
Anisic Acid                      100-09-4
Benzalacetone                    122-57-6
Benzaldehyde Dimethylacetal      1125-88-8
Benzyl Ether                     103-50-4
Benzyl Formate                   104-57-4
Benzyl Mercaptan                 100-53-8
Benzyl Salicylate                118-58-1
Calcium Citrate                  813-94-5
Calcium Glycerophosphate         27214-00-2
Calcium Hypophosphite            7789-79-9
Calcium lodate                   7789-80-2
Propanoic acid, 2-hydroxy-,      814-80-2
calcium salt (2:1)
Calcium Phosphate Tribasic       7758-87-4
Calcium Propionate               4075-81-4
Calcium Pyrophosphate            7790-76-3
Cholic Acid                      81-25-4
Choline                          123-41-1
Choline Bitartrate               87-67-2
trana-Cinnamic Aldehyde          14371-10-9
Cinnamyl Alcohol                 104-54-1
Citronellol                      106-22-9
Copper(I)Iodide                  7681-65-4
D-(+)-Glucono-1,5-lactone        90-80-2
D-(−)-Tartaric Acid              147-71-7
D-Isoascorbic Acid               89-65-6
D-Tyrosine                       556-02-5
Sodium dehydroacetate            4418-26-2
Deoxycholic Acid                 83-44-3
Dibenzyl Ketone                  102-04-5
Diethyl L-(+)-Tartrate           87-91-2
Diethyl Succinate                123-25-1
Dimethylacetal                   534-15-6
DL-Cystine                       923-32-0
DL-Proline                       609-36-9
DL-Tartaric Acid                 133-37-9
DL-Tyrosine                      556-03-6
DL-Valine                        516-06-3
Enanthoic Acid                   111-14-8
Erythorbic Acid Sodium Salt      7378-23-6
Ethyl 2-Aminobenzoate            87-25-2
Ethyl Cinnamate                  103-36-6
Ethyl n-Valerate                 539-82-2
Ethyl Phenylacetate              101-97-3
Ethyl Salicylate                 118-61-6
Ethyl Sulfide                    352-93-2
Ethyl Vanillin                   121-32-4
Ethylene Mercaptan               540-63-6
Farnesene                        502-61-4
Folic acid                       59-30-3
gamma-Nonanolactone              104-61-0
gamma-Valerolactone              108-29-2
Gluconic Acid                    526-95-4
Gluconic Acid Potassium Salt     299-27-4
Glutaric Acid                    110-94-1
Guanosine-5′-monophosphate,      1333479
disodium salt
Heliotropine                     120-57-0
Hippuric Acid                    495-69-2
Hydroquinone Dimethyl Ether      150-78-7
Inosine-5′-monophosphate         4691-65-0
Sodium Salt
iso-Amyl Mercaptan               541-31-1
Isoamyl Salicylate               87-20-7
iso-butyl n-Hexanoate            105-79-3
isovaleraldehyde                 590-86-3
Isoamyl Benzoate                 94-46-2
Isoamyl Formate                  110-45-2
Isoamyl n-Butyrate               106-27-4
Isoamylamine                     107-85-7
Isobutyl n-Butyrate              539-90-2
Isocaproic Acid                  646-07-1
Isoeugenol                       97-54-1
Isopropyl Benzoate               939-48-0
Isopropyl Formate                625-55-8
Isopropyl N-Butyrate             638-11-9
Isopropyl Propionate             637-78-5
isobutyl Mercaptan               513-44-0
L-(+)-Isoleucine                 73-32-5
L-(−)-Apple Acid                 97-67-6
L-2-Aminopropionic Acid          56-41-7
L-Aspartic acid                  56-84-8
L-Carnitine                      541-15-1
L-Cysteine Hydrochloride         52-89-1
L-Glutamic Acid Hydrochloride    138-15-8
L-Glutamine                      56-85-9
L-Hydroxyproline                 51-35-4
L-Proline                        147-85-3
L-Serine                         56-45-1
L-Threonine                      72-19-5
L-Valine                         72-18-4
N-Acetylglycine                  543-24-8
n-Amyl Formate                   638-49-3
n-Amyl n-Caproate                540-07-8
n-Butyl n-Caproate               626-82-4
n-Butyl Propionate               590-01-2
n-Butyl Salicylate               2052-14-4
n-Decanoic Acid                  334-48-5
n-Hexyl Mercaptan                111-31-9
n-Proply Benzoate                2315-68-6
n-Propyl Isobutyrate             644-49-5
n-Tetradecanoic Acid             544-63-8
Nitrilotriacetic Acid            5064-31-3
Trisodium Salt
o-Tolunethiol                    137-06-4
Orotic Acid                      65-86-1
p-Acetamidobenzoic Acid          556-08-1
p-Anise Alcohol                  105-13-5
Phenoxyacetic Acid               122-59-8
Phenyl Acetate                   122-79-2
Piperine                         94-62-2
Pivalic Acid                     75-98-9
Potassium Benzoate               528-25-2
Potassium Diphosphate            7320-34-5
Potassim Hypophosphite           7782-87-8
Potassium Metaphosphate          7790-53-6
Potassium Sulfite                10117-38-1
Quinine Hydrochloride            130-89-2
sec-Amyl Alcohol                 6032-29-7
Sodium D-Pantothenate            867-81-2
Di(2-ethylhexyl) sulfosuccinic   577-11-7
acid, sodium salt
Sodium Sorbate                   7757-81-5
Succinic acid, disodium salt     150-90-3
Sodium Taurocholate              145-42-6
Taurine                          107-35-7
Thiamine Nitrate                 532-43-4
Thioanisole                      100-68-5
Tiglic Acid                      80-59-1
Tri-n-butyrin                    60-01-5
Triacetin                        102-76-1
Trisodium Citrate                68-04-2
Veratraldehyde                   120-14-9
Veratrole                        91-16-7
Vitamin P                        520-26-3
Vitamin U Chloride               582174
L-Methionine                     63-68-3
2-Chloro-1-propanol              78-89-7
2-Ethylbutyric acid              88-09-5
2-Methylbutyraldehyde            96-17-3
2-Methyl-5-ethylpyridine         104-90-5
n-propyl butyrate                105-66-8
Ethyl caprylate                  106-32-1
Propyl propionate                106-36-5
2-Methylpyrazine                 109-08-0
3,3,5-Trimethyl-1-cyclohexanol   116-02-9
Ethyl caproate                   123-66-0
o-methoxybenzaldehyde            135-02-4
2,4-Hexadienal                   142-83-6
3-Hexanone                       589-38-8
3-Methyl-2-butanol               598-75-4
Methyl isopropenyl ketone        814-78-8
3-Methyl-2-butanethiol           2084-18-6
3,5,5-Trimethylhexanol           3452-97-9
Methylglyoxal                    78-98-8
Malonaldehyde                    542-78-9
1,4-Dithiane                     505-29-3
Amylcinnamaldehyde               122-40-7
Benzyl cinnamate                 103-41-3
tert-Butylhydroquinone           1948-33-0
Fusidic Acid Sodium Salt         751-94-0
Hydroxycitronellal               107-75-5
Musk ketone                      81-14-1
L-Asparagine                     70-47-3
phenethyl acetate                103-45-7
Riboflavin 5-Phosphate           146-17-8
Potassium Sodium Tartrate        304-59-6
Galactaric acid                  526-99-8
Sodium Tartrate                  868-18-8
Trisodium phosphate              7601-54-9
Disodium Pytophosphate           7758-16-9
Magnesium chloride               7786-30-3
Sodium Polymethacrylate          54193-36-1
propiophenone                    93-55-0
2-ethylhexanoic acid             149-57-5
3,7,7-trimethyl bicyclohep-3-    13466-78-9
ene
2,6-dimethyl-4-heptanol          108-82-7
5-isopropyl-2-methyl-phenol      499-75-2
L-Bomyl acetate                  5655-61-8
caryophyllene                    87-44-5
hydroxymethylpyrone              118-71-8
neosperidin dihydrochalcone      20702-77-6
2,2-Dibromo-3-                   10222-01-2
nitrilopropionamide
Xylitol                          87-99-0
Sulfosalicylic acid              97-05-2
Riboflavin 5′-(dihydrogen        130-40-5
phosphate), monosodium salt
Ethylenediaminetetraacetic       139-33-3
acid, disodium salt
Gallic acid                      149-91-7
Carbonic acid                    463-79-6
Potassium carbonate,             6381-79-9
sesquihydrate
Magnesium phosphate tribasic     7757-87-1
diallyl sulfide                  592-88-1
ethyl 4-oxopentanoate            539-88-8
methyl caproate                  106-70-7
isopropyl isobutyrate            617-50-5
diethyl hydroxybutanedioate      2065419
propyl isopentanoate             557-00-6
benzyl ethyl ether               539-30-0
isobutyl isopentanoate           589-59-3
propyl hexanoate                 626-77-7
4-methylquinoline                491-35-0
methyl cinnamate                 103-26-4
cumic alcohol                    536-60-7
thujone                          471-15-8
dihydrocarveol                   619-01-2
fenchyl alcohol                  1632-73-1
Nerol                            106-25-2
isopentyl isopentanoate          659-70-1
methyleugenol                    93-15-2
methyl 2-naphtyl ketone          93-08-3
diphenyldisulfide                882-33-7
citronellyl acetate              150-84-5
menthyl acetate                  89-48-5
menthyl isovalerate              16409-46-4
5-Ethyl-3-hydroxy-4-methyl-      698-10-2
2(5H)-furanone
malic acid                       6915-15-7
3-methylbutanoic acid butyl      109-19-3
ester
3-phenyloxiranecarboxylic acid   121-39-1
ethyl ester
1,2-Benzisothiazol-3(2H)-one     6381-61-9
1,1-dioxide, ammonium salt
1-methyl-4-(1-methylethyl)-      99-85-4
1,4-Cyclohexadiene
3-mercapto-2-Butanol             54812-86-1
(1R)-2,6,6-                      7785-70-8
trimethylbicyclo[3.1.1]hept-2-
ene
(1S)-6,6-dimethyl-2-             18172-67-3
methylenebicyclo[3.1.1]heptane
1-methyl-4-)1-                   586-62-9
methylethylidene)cyclohexene
1-(3-pyridinyl)ethanone          350-03-8
1-pyrazinylethanone              22047-25-2
1-(2-furyl)-2-propanone          6975-60-6
1-Penten-3-one                   1629-58-9
2,3-pentanedione                 600-14-6
2,5-dimethylpyrazine             123-32-0
2-isobutyl-3-methoxypyrazine     24683-00-9
4-methyl-2,3-pentanedione        7493-58-5
5-methylfurfural                 620-02-0
Dimethyltrisulfide               3658-80-8
furfuryl acetate                 623-17-6
furfurylmethylether              13679-46-4
terpinen-4-ol                    562-74-3
Calcium sorbate                  7492-55-9
Potassium lactate                996-31-6
1-Hydroxyethylidene-1,1-         2809-21-4
diphosphonic acid
L-glutamic acid monopotassium    19473-49-5
salt
3-methyl-2-buten-1-ol            556-82-1
phenylethanal                    122-78-1
4′-Methoxyacetophenone           100-06-1
L-borneol                        464-45-9
2,4-Hexadien-1-ol                111-28-4
D-Fenchone                       4695-62-9
3-Phenylpropyl formate           104-64-3
Cinnamyl formate                 104-65-4
D-galacturonate                  685-73-4
D-glucuronate                    1700908
5′ IMP                           131-99-7
1-Methoxy-4-methylbenzene        104-93-8
2-Methylbutanoic acid            116-53-0
2,4,6-Tribromophenol             118-79-6
3-Ethyl pyridine                 536-78-7
Zinc acetate                     557-34-6
Methyl pentanoate                624-24-8
Methylthioethane                 624-89-5
3-Penten-2-one                   625-33-2
Glyocholic acid                  475-31-0
m-Methoxybenzoic acid            586-38-9
alpha-Hydroxypropionic acid      598-82-3
Methyl 2-furoate                 611-13-2
2-Furancarboxylic acid, propyl   615-10-1
ester
Benzylacetoscetic acid, ethyl    620-79-1
ester
2,5-Dimethyl pyrrole             625-84-3
4-methyl-1,1′-biphenyl           644-08-6
pisopropylacetophenone           645-13-6
4-methyl-thiazole                693-95-8
gamma-Decalactone                706-14-9
2-aceltylpyrrole                 1072-83-9
2-acetylpyridine                 1122-62-9
tetramethyl-pyrazine             1124-11-4
Methyl 4-phenylbutyrate          2046-17-5
2,3,6-trimethyl-phenol           2416-94-6
2-Methoxypyrazine                3149-28-8
2-Ethylfuran                     3208-16-0
2,3-dimethyl-pyrazine            5910-89-4
Thiophenethiol                   7774-74-5
o-Tolyl isobutyrate              36438-54-7
cis-3-Hexenyl pyruvate           68133-76-6
cis-3-Hexenyl cis-3-hexenoate    61444-38-0
trans-2-Hexenyl isovalerate      68698-59-9
trans-2-Hexenyl formate          53398-78-0
trans-2-Hexenyl valerate         56922-74-8
1-Octen-3-yl butyrate            16491-54-6
Methyl 4-(methylthio)butyrate    53053-51-3
2,4-Octadien-1-ol                18409-20-6
2,4-Nonadien-1-ol                62488-56-6
2,4-Decadien-1-ol                18409-21-7
(e,z)-2,6-Nonadienyl acetate     68555-65-7
3-Hexenal                        4440-65-7
Tetrahydro-2-furanmethanol       637-64-9
acetate
Methyl benzaldehyde              1334-78-7
Dodecylsulfonic acid             1510-16-3
Methylethyl disulfide            4253-89-8
Farnesol                         4602-84-0
Thiobenzoic acid, S-methyl       5925-68-8
ester
Hexyl benzoate                   6789-88-4
2,5-Diethyltetrahydrofuran       41239-48-9
Zinc hydrosulfite                7779-86-4
(2R,3S)-Tartaric Acid            147-73-9
Ethylsufuric acid                540-82-9
1,2,2-Trimethyl-1,3-             5394-83-2
cyclopentanedicarboxylic acid
2-Methyl-3-buten-2-ol            115-18-4
trans-2-Hexenal                  6728-26-3
4-Hexen-3-one                    2497-21-4
1-Hexen-3-ol                     4798-44-1
2-Methyl-1-butanethiol           1878-18-8
4-Methylcyclohexanone            589-92-4
3-Heptanol                       589-82-2
o-methylanisole                  578-58-5
trans-2-octenal                  2363-89-5
2,3,4-Trimethyl-3-pentanol       3054-92-0
Acetylacetaldehyde dimethyl      5436-21-5
acetal
p-methylacetophernone            122-00-9
o-aminoacetophenone              551-93-9
4-Propylphenol                   645-56-7
2,4-Dimethylanisole              6738-23-4
Benzyl methyl sulfide            766-92-7
Methyl penylacetate              101-41-7
4-Ethoxybenzaldehyde             10031-82-0
p-tolyl acetate                  140-39-6
2,6-Dimethoxyphenol              91-10-1
Isoborneol                       124-76-5
Methyl 2-methoxybenzoate         606-45-1
Phenylacetaldehyde dimethyl      101-48-4
acetal
3-Phenylpropyl acetate           122-72-5
Ethyl 3-phenylpropionate         2021-28-5
Benzyl butyrate                  103-37-7
Anisyl acetate                   104-21-2
Isobutyl phenylacetate           102-13-6
p-vinylphenol                    2628-17-3
o-tolyl acetate                  533-18-6
2,5-Dihydroxybenzoic acid        490-79-9
o-methoxyphenyl acetate          613-70-7
Lactobionic acid                 96-82-2
Magnesium hydrogen               7782-75-4
phosphate
trihydrate
Iberverin                        505-79-3
alpha-methylcinnamaldehyde       101-39-3
benzyl phenylacetate             102-16-9
1,3-dimercaptopropane            109-80-8
p-cymen-8-ol                     1197-01-9
phenethyl antranilate            133-18-6
trihydroxybutyrophenone          1421-63-2
o-methoxycinnamaldehyde          1504-74-1
3-propylidene phthalide          17369-59-4
trans,trans-2,4-decadienal       25152-84-5
piperonyl acetate                326-61-4
2,3-hexanedione                  3848-24-6
isopropyl phenylacetate          4861-85-2
ethyl 3-hydroxybutyrate          5405-41-4
furfural acetone                 623-15-4
beta-(2-furyl)acrolein           623-30-3
linalyl anthranilate             7149-26-0
citral diethyl acetal            7492-66-2
allyl anthranilate               7493-63-2
acetyl tributyl citrate          77-90-7
butyl anthranilate               7756-96-9
cyclohexyl anthranilate          7779-16-0
isoamyl cinnamate                7779-65-9
isobutyl anthranilate            7779-77-3
carvyl acetate                   97-42-7
carveol                          99-48-9
3-(Methylthio)propionaldehyde    3268-49-3
Alpha-damascone                  43052-87-5
Dimethyldicarbonate              4525-33-1
Procaine                         59-46-1
5-hydroxy-6-methyl-3,4-          65-23-6
pyridinedimethanol
2-methoxy-Naphthalene            93-04-9
Methyl nicotinate                93-60-7
Ethyl benzoylacetate             94-02-0
Phenethyl benzoate               94-47-3
2-methyl-pentanoic acid          97-61-0
Cyclohexanecarboxylic acid       98-89-5
Methyl b-phenylpropionate        103-25-3
Benzyl 3-methyl butanoate        103-38-8
Naphthalene-2-sulfonic acid      120-18-3
Methyl 4-methoxybenzoate         121-98-2
3-Phenylprop-2-enyl cinnamate    122-69-0
7-methyl-3-methylene-1,6-        123-35-3
Octadiene
Levulinic acid                   123-76-2
2-Mercaptobenzoic acid           147-93-3
m-Dimethoxybenzene               151-10-0
3-butyl-1(3H)-isobenzofuranone   6066-49-5
5-Methylquinoxaline              13708-12-8
2-Ethyl Pyrazine                 13925-00-3
trimethyl-pyrazine               14667-55-1
2-ethyl-3-methyl-pyrazine        15707-23-0
2,3-diethyl-pyrazine             15707-24-1
2,3-diethyl-5-methyl-pyrazine    18138-04-0
2-Methylthiopyrazine             21948-70-9
5-Methyl-3H-furan-2-one          591-12-8
cis-3-Hexen-1-ol                 928-96-1
3,7-Dimethyl-1,3,6-octatriene    13877-91-3
calcium cyclamate                139-06-0
aconitic acid                    499-12-7
2-Dehydrolinalool                29171-20-8
2-Mercaptopropionic acid         79-42-5
3-Methyl-2-butenal               107-86-8
Allylacetic acid                 591-80-0
Allyl cyclohexylacetate          4728-82-9
Allyl cyclohexylpropionate       2705-87-5
Allyl phenoxyacetate             7493-74-5
Allyl phenylacetate              1797-74-6
Allyl alpha-ionone               79-78-7
Butyl butyrolactate              7492-70-8
Cinnamyl isobutyrate             103-59-3
Cinnamyl propionate              103-56-0
Dibenzyl disulfide               150-60-7
Isobornyl acetate                125-12-2
Methyl heptyne carbonate         111-12-6
Triethyl citrate                 77-93-0
gamma-Undecalactone              104-67-6
alpha-Amylcinnamyl alcohol       101-85-9
1,3,4,6,7,8-Hexahydro-           1222-05-5
4,6,6,7,8,8-hexanmethyl
cyclopenta[g] [2]benzopyran
2-Ethylbutyl acetate             10031-87-5
Triphosphoric acid,              13845-36-8
pentapotassium salt
L-(+)-Lactic acid                79-33-4
Mannitol                         87-78-5
2-Methoxy-4-methylphenol         93-51-6
1,2,3-Propanetricarboxylic acid, 144-33-2
2-hydroxy-, disodium salt
Ethanesulfonic acid, 2-hydroxy-, 1562-00-1
monosodium salt
2-Methoxy-4-propylphenol         2785-87-7
3,7-Dimethyl-3-octanol           78-69-3
2-Pentyl furan                   3777-69-3
Butanoic acid, 3-oxo-, butyl     591-60-6
ester
4-(4-Hydroxy-4-methyl pentyl)-3- 31906-04-4
cyclohexene-1-carboxaldehyde
Methyl 3-oxo-2-                  24851-98-7
pentylcyclopentanescetate
Naphthalene, 2-(2-               2173-57-1
methylpropoxy)-
Perillol                         536-59-4
2-Acetyl-1-methylpyrrole         932-16-1
4-Allyl-2,6-dimethoxyphenol      6627-88-9
Butyl levulinate                 2052-15-5
D-(+)-Camphoric acid             124-83-4
D(+)-10-Camphorsulfonic acid     3144-16-9
L-(−)-Carvone                    6485-40-1
(−)-Carvyl propionate            97-45-0
(−)-Caryophyllene oxide          1139-30-6
Cyclohexylacetic acid            5292-21-7
3-Cyclopentylpropionic acid      140-77-2
(−)-Dihydrocarvyl acetate        20777-49-5
3,3-Dimethylacrylic acid         541-47-9
2,4-Dimethylbenzaldehyde         15764-16-6
1,4-Dithiane-2,5-diol            40018-26-6
Ethanesulfonic acid              594-45-6
Ethyl butyrylacetate             3249-68-1
Ethyl (methylthio) acetate       4455-13-4
Ethyl pyruvate                   617-35-6
Ethyl sorbate                    2396-84-1
5-Formyl-2-furansulfonic acid,   31795-44-5
sodium salt
Furfuryl mercaptan               98-02-2
1,6-Hexanedithiol                1191-43-1
trans-2-Hexenoic acid            13419-69-7
trans-2-Hexen-1-ol               928-95-0
4-(4-Hydroxyphenyl)-2-butanone   5471-51-2
Isopulegol                       89-79-2
Isopulegyl acetate               89-49-6
2-Ketobutyric acid               600-18-0
(−)-Limonene                     5989-54-8
4-Methoxyphenylacetone           122-84-9
Methyl cyclohexanecarboxylate    4630-82-4
3-Methylcyclohexanone            591-24-2
3-Methyl-2-cyclohexen-1-one      1193-18-6
3-Methyl-1,2-cyclopentanedione   765-70-8
3-Methyl-2-cyclopenten-1-one     2758-18-1
N-Methyl-D-glucamine             6284-40-8
Methyl 3-(methylthio)propionate  13532-18-8
4-Methyl-5-thiazoleethanol       137-00-8
5-Methyl-2-                      13679-70-4
thiophenecarboxaldehyde
DL-3-Methylvaleric acid          105-43-1
(−)-Myrtenal                     564-94-3
Nopol                            128-50-7
gamma-Octanoic lactone           104-50-7
3-Octanol                        589-98-0
E-2-Octenoic acid                1871-67-6
Pamoic acid                      130-85-8
4-Phenyl-2-butyl acetate         10415-88-0
1-Phenyl-1,2-propanedione        579-07-7
2-Phenylpropyl butyrate          80866-83-7
2-Phenylpropyl isobutyrate       65813-53-8
cis-2-Hexen-1-ol                 928-94-9
Bis(methylthio)methane           1618-26-4
Magnesium carbonate              39409-82-0
hydroxide, Light
N-Acetyl-L-methionine            65-82-7
4-Methyl-5-vinylthiazole         1759-28-0
2-Methyl-1-phenyl-2-propanol     100-86-7
3-Phenylpropionaldehyde          104-53-0
N-Benzyl-2-phenylethylamine      3647-71-0
1-Phenylethyl propionate         120-45-6
3-Phenylpropyl isobutyrate       103-58-2
Allyl hexanoate                  123-68-2
alpha, 4-Dimethylbenzylalcohol   536-50-5
(−)-Menthyl lactate              59259-38-0
2,6-Dimethylthiophenol           118-72-9
2,4,5-Trimethylthiazole          13623-11-5
Ethyl 3-(methylthio)propionate   13327-56-5
Phenylethyl isovalerate          140-26-1
2-Propylpyrazine                 18138-03-9
2-Methyltetrahydrofuran-3-one    3188-00-9
Ethyl 2-(methyldithio)propionate 23747-43-5
3,4-(Dimethyl-1,2-               13494-06-9
cyclopentanedione
Difurfurylsulfide                13678-67-6
Difurfuryldisulfide              4437-20-1
3-(Methylthio)propanol           505-10-2
Methyl phenyl disulfide          14173-25-2
2-(Methyldithio)-                67952-60-7
isobutyraldehyde
Methyl 2-thiofuroate             13679-61-3
2-Isobutylthiazole               18640-74-9
4-Methyl-5-thiazolylethyl acetate 656-53-1
2-Acetylthiazole                 24295-03-2
2-Ethyl-3,5(6)-dimethylpyrazine  27043-05-6
5-Methyl-6,7-dihydro-5H-         23747-48-0
cyclopenta(b)pyrazine
Cinnamyl acetate                 103-54-8
2,5-Dihydroxy-2,5-dimethyl-1,4-  55704-78-4
dithiane
5,6,7,8-Tetrahydroquinoxaline    34413-35-9
2-Methyl-3-furanethiol           28588-74-1
Styrallyl acetate                93-92-5
2-Methylhexanoic acid            4536-23-6
2-Methylheptanoic acid           1188-02-9
2,2,6-Trimethylcycloheanone      2408-37-9
L-Tyrosine ethyl ester           4089-07-0
hydrochloride
Ethyl 4-methoxybenzoate          94-30-4
4-Ethylbenzaldehyde              4748-78-1
N-Ethyl-p-menthane-3-            39711-79-0
carboxamide
1-(2-Furyl)-1,3-butanedione      25790-35-6
Menthofuran                      494-90-6
Methylsulfuric acid sodium salt  512-42-5
Sucrose diacetate                126-13-6
hexaisobutyrate
N,2,3-Trimethyl-2-               51115-67-4
isopropylbutamide
Tripropionin                     139-45-7
(+/−)-Citronellic acid           502-47-6
5-Acetyl-2,4-dimethylthiazole    38205-60-6
Neryl acetate                    141-12-8
Benzyl propionate                122-63-4
1R-(−)-Camphorsulfonic acid      35963-20-3
3,4-Hexanedione                  4437-51-8
cis-3-Hexenoic acid              4219-24-3
cis-4-Heptenal                   6728-31-0
(E,Z)-2,6-nonadienal             557-48-2
trans-2,trans-6-Nonadienal       17587-33-6
4-Methyl-2-pentenal              5362-56-1
cis-6-Nonenal                    2277-19-2
Methyl propyl disulfide          2179-60-4
8-p-Menthen-1-ol                 138-87-4
p-Menthan-2-one                  499-70-7
Bisabolene                       495-62-5
Ethyl cyclohexanecarboxylate     3289-28-9
Phenylpyruvate                   156-06-9
Hydroxypyruvate                  1113-60-6
4-Methyl-2-oxopentanoate         816-66-0
(+)-Neomenthol                   2216-52-6
trans-Citral                     141-27-5
Piperitenone                     491-09-8
Sabinene hydrate                 546-79-2
Perillyl aldehyde                2111-75-3
2-Hydroxyethanesulfonate         107-36-8
Acetyl isovaleryl                13706-86-0
Acetyl valeryl                   96-04-8
Butylidene phthalide             551-08-6
Carvacryl ethyl ether            4732-13-2
Ethyl vanillin propylene glycol  68527-76-4
acetal
Hexyl hexanoate                  6378-65-0
2-Methyl-5-(methylthio)-furan    13678-59-6
2-Methyl-4-pentenoic acid        1575-74-2
2-Methyl-4-propyl-1,3-oxathiane  67715-80-4
3-Methylthio-1-hexanol           51755-66-9
cis-6-Nonenol                    35854-86-5
Rose oxide                       16409-43-1
L-Linalool                       126-91-0
5,6-Dimethyl-8-                  4674-50-4
isopropenylbicyclo[4,4,0]dec-1-
en-3-one
2-Ethyl-3,5-dimethylpyrazine     13925-07-0
2-Isopropylpyrazine              29460-90-0
2-Isobutyl-3-methyl-pyrazine     13925-06-9
2-Methoxy-3-sec-butyl-pyrazine   24168-70-5
2-Methylthio-3(6)-methyl-        67952-65-2
pyrazine
Benzylcarbinyl propionate        122-70-3
Bornyl acetate                   76-49-3
furaneol                         3658-77-3
Methoxycinnamaldehyde            1963-36-6
Methylphenol, hydrogen sulfate   68127-34-4
Lactitol monohydrate             81025-04-9
2H-Pyrrole, 3,4-dihydro-         5724-81-2
2-Butenal, 2-methyl-, (E)-       497-03-0
2-Pentenal                       764-39-6
Ethanethioic acid, S-methyl      1534-08-3
ester
2-Hexenal                        505-57-7
2-Methyl-2-pentenal              623-36-9
Cyclopentanethiol                1679-07-8
Butane, 2-ethoxy-                2679-87-0
S-Ethyl thioacetate              625-60-5
ethyl methyl carbonate           623-53-0
3(2H)-Furanone, 2,5-dimethyl-    14400-67-0
Allyl propionate                 2408-20-0
methyl 2-methylbutanoate         868-57-5
2-Butanone, 1-(methylthio)-      13678-58-5
Ethanethioic acid, S-propyl ester 2307-10-0
1,2-Butanedithiol                16128-68-0
6-Methyl-3,5-heptadiene-2-one    1604-28-0
2-Octen-4-one                    4643-27-0
2,5-dimethyl-3-furanthiol        55764-23-3
2-Heptenoic acid                 189999-28-5
Butanoic acid, 2-propenyl ester  2051-78-7
6-Methyl-5-hepten-2-ol           1569-60-4
trans-2-Octen-4-ol               20125-81-9
cis-3-Octen-1-ol                 20125-84-2
1-Butanol, 2-methyl-, acetate    624-41-9
4-methyl-alpha-methylstyrene     1195-32-0
trans-3-Phenyl-2-propen-1-ol     4407-36-7
Benzeneacetaldehyde, alpha-      93-53-8
methyl-
Benzene, (2-methoxyethyl)-       3558-60-9
Cyclohexene, 1-methyl-4-(1-      7705-14-8
methylethenyl)-, (+−)-
Phenol, 2-(methylthio)-          1073-29-6
2-Hexen-1-yl acetate             2497-18-9
3-Hexen-1-ol, acetate, (Z)-      3681-71-8
5-Hydroxy-4-octanone             496-77-5
butyl 2-methylpropanoate         97-87-0
Benzofuran-2-carboxaldehyde      4265-16-1
DL-Lysine                        70-54-2
1-Hexanethiol, 2-ethyl-          7341-17-5
2′,4′-Dimethylacetophenone       89-74-7
2-Pentylpyridine                 2294-76-0
1-Methoxy-4-propyl benzene       104-45-0
1-Hydroxy-2-methoxy-4-ethyl      2785-89-9
benzene
Nonalactone                      6008-27-1
Cyclohexyl propionate            6222-35-1
Allyl 2-ethylbutyrate            7493-69-8
Butanoic acid, 3-oxo-, 2-        7779-75-1
methylpropyl ester
n-Butyl pentanoate               591-68-4
3,7-Dimethyl-1-octanol           106-21-8
3-Buten-2-one, 3-methyl-4-       1901-26-4
phenyl-
2-Propenoic acid, 3-phenyl-,     1754-62-7
methyl ester, (E)-
Benzene, 4-ethenyl-1,2-          6380-23-0
dimethoxy-
Benzenepropanol, alpha,alpha-    103-05-9
dimethyl-
Benzene, (butoxymethyl)-         588-67-0
Dimethyl anthranilate            85-91-6
2-Hexanoylfuran                  14360-50-0
Cyclohexyl butyrate              1551-44-6
Naphthalene, 2-ethoxy-           93-18-5
Acetoacetic acid isoamyl ester   2308-18-1
Propanoic acid, 2-methyl-, 4-    103-93-5
methylphenyl ester
4-(4-Methoxyphenyl)-2-           104-20-1
butanone
Isobutyl benzoate                120-50-3
Benzene, 1,2-dimethoxy-4-(1-     93-16-3
propenyl)-
beta-                            10415-87-9
Phenylethylmethylethylcarbinol
1,1-Dimethoxy-2-phenylpropane    90-87-9
Geranyl formate                  105-86-2
Bornyl formate                   7492-41-3
6-Octen-1-ol, 3,7-dimethyl-,     105-85-1
formate
Benzeneacetic acid, butyl ester  122-43-0
3,5,9-Undecatrien-2-one, 6,10-   141-10-6
dimethyl-
Anisyl propionate                7549-33-9
Butanoic acid, 3-phenyl-2-       103-61-7
propenyl ester
2-Propenoic acid, 3-phenyl-, 2-  122-67-8
methylpropyl ester
Eugenyl acetate                  93-28-7
3-Methylbutyl phenylacetate      102-19-2
Benzoic acid, 2-(methylamino)-,  65505-24-0
2-methylpropyl ester
Phenoxy ethyl isobutyrate        103-60-6
Anisyl butyrate                  6963-56-0
2,6-Octadien-1-ol, 3,7-dimethyl-, 105-91-9
propanoate, (Z)-
Isobornyl propionate             2756-56-1
1,3,5-Trithiane, 2,2,4,4,6,6-    828-26-2
hexamethyl-
Geranyl N-butyrate               106-29-6
Geranyl isobutyrate              2345-26-8
Thiophene, 2,2′-dithiobis-       6911-51-9
2-Propenoic acid, 3-phenyl-,     7779-17-1
cyclohexyl ester
Benzeneacetic acid, 3-phenyl-2-  7492-65-1
propenyl ester
Anisyl phenylacetate             102-17-0
2-Propenoic acid, 3-phenyl-, 3-  122-68-9
phenylpropyl ester
Geranyl phenylacetate            102-22-7
hexyl 2-methylbutyrate           10032-15-2
4-heptanolide                    105-21-5
Neral                            106-26-3
(E)-2-octenol                    18409-17-1
Ethyl 3-hydroxyhexanoate         2305-25-1
isopropyl hexanoate              2311-46-8
hexyl butanoate                  2639-63-6
bis(2-methyl-3-furyl)disulfide   28588-75-2
3-hydroxy-4,5-dimethyl-2(5H)-    28664-35-9
furanone
2-acetyl-2-thiazoline            29926-41-8
(E,E)-2,4-octadienal             30361-28-5
geranyl acetone                  3796-70-1
1-octen-3-one                    4312-99-6
3-mercapto-2-pentanone           67633-97-0
(Z)-3-hexenal                    6789-80-6
4-hexanolide                     695-06-7
5-octanolide                     698-76-0
delta-decalactone                705-86-2
4-vinylguaiacol                  7786-61-0
Amyl alicylate                   2050-08-0
Cyclohexyl formate               4351-54-6
Dimethylbenzylcarbinyl acetate   151-05-3
Geranyl propionate               105-90-8
Terpinyl acetate                 80-26-2
isopropyl 3-methylbutanoate      32665-23-9
isopropyl 2-methylbutanoate      6676-71-4
3-Hexenyl 3-methylbutanoate      10032-11-8
Isoamyl 2-methylbutyrate         27625-35-0
3-Octyl acetate                  4864-61-3
Benzyl isobutyrate               103-28-6
Cis-3-hexenyl butyrate           16491-36-4
Cis-3-hexenyl lactate            61931-81-5
Citronellyl butyrate             141-16-2
Citronellyl propionate           141-14-0
Isoamyl hexanoate                2198-61-0
1,3,5-Undecatriene               16356-11-9
1-Benzyloxy-2-methoxy-4-         120-11-6
propenyl benzene
1-Octen-3-yl acetate             198242
2-Acetyl-3-ethyl pyrazine        32974-92-8
2-Isopropyl-4-methyl thiazole    15679-13-7
2-Methyl-2-pentenoic acid        3142-72-1
2-sec-butyl thiazole             18277-27-5
4,5-Dimethyl thiazole            3581-91-7
4-(2,6,6-Trimethyl-2-cyclohexen- 31499-72-6
1-yl)butan-2-one
4-(2,6,6-Trimethyl cyclohexa-    23696-85-7
1,3-dienyl)but-2-en-4-one
Acetaldehyde phenethyl propyl    7493-57-4
acetal
Acetaldehyde ethyl cis-3-        28069-74-1
hexenyl acetal
Acetone propylene glycol acetal  1193-11-9
Acetyl isoeugenol                93-29-8
2-Acetyl-5-methyl furan          1193-79-9
Allyl cyclohexylbutyrate         7493-65-4
Alpha,alpha-                     10094-34-5
dimethylphenethylbutyrate
Alpha,alpha-dimethyl phenethyl   10058-43-2
formate
Alpha,beta-santalol              11031-45-1
Alpha-amyl cinnamaldehyde        91-87-2
dimethyl acetal
Alpha-fenchyl acetate            13851-11-1
Alpha-furfuryl pentanoate        36701-01-6
Alpha-ionol                      25312-34-9
6-Methyl-alpha-ionone            79-69-6
Alpha-methyl-p-                  103-95-7
isopropylphenylpropanaldehyde
Alpha-n-amyl-beta-phenylacryl    7493-78-9
acetate
Alpha-piperitone                 6091-50-5
Alpha-n-amyl-beta-phenyl acryl   7493-80-3
isovalerate
6-Amyl-alpha-pyrone              27593-23-3
Anisyl formate                   122-91-8
Benzylcarbinyl 2-methyl butyrate 24817-51-4
Benzylcarbinyl 3-phenyl          103-53-7
propenoate
Benzylcarbinyl alpha-toluate     102-20-5
Benzylcarbinyl butyrate          103-52-6
Benzylcarbinyl caproate          6290-37-5
Benzylcarbinyl formate           104-62-1
Benzylcarbinyl isobutyrate       103-48-0
Benzylcarbinyl salicylate        87-22-9
Benzylcarbinyl tiglate           55719-85-2
Benzyl dipropyl ketone           7492-37-7
Benzyl tiglate                   37526-88-8
Beta-homocyclocitral             472-66-2
Beta-ionol                       22029-76-1
3-Phenylpropyl propanoate        122-74-7
Bois de rose oxide               7392-19-0
Butyl 2-methyl butyrate          15706-73-7
Butyl cinnamate                  538-65-8
ortho-sec-Butyl cyclohexanone    14765-30-1
isobutyl cis-2-methyl-2-         7779-81-9
butenoate
5-n-Butyl-delta-valerolactone    3301-94-8
Campholenic aldehyde             4501-58-0
Cedran-8-yl acetate              77-54-3
Cinnamyl isovalerate             140-27-2
Cis-3-hexenyl benzoate           25152-85-6
Cis-3-hexenyl caproate           31501-11-8
Cis-3-hexenyl formate            33467-73-1
Cis-3-hexenyl isobutyrate        41519-23-7
Cis-3-hexenyl phenylacetate      42436-07-7
Cis-3-hexenyl propionate         33467-74-2
Cis-3-hexenyl tiglate            67883-79-8
Cis-3-hexenyl valerate           35852-46-1
cis-4-Hepten-1-ol                6191-71-5
Cis-5-octen-1-ol                 64275-73-6
Citral dimethyl acetal           7549-37-3
Citronellyl isobutyrate          97-89-2
Citronellyl isovalerate          68922-10-1
Citronellyl valerate             7540-53-6
Citroxide                        7416-35-5
Cocal                            21834-92-4
p-Cresyl alpha-toluate           101-94-0
p-Cresyl isovalerate             55066-56-3
Dehydro-beta-cyclocitral         116-26-7
8,8-Diethoxy-2,6-dimethyl-2-     7779-94-4
octanol
5,7-Dihydro-2-methyl thieno(3,4- 36267-71-7
d)pyrimidine
2,5-Dihydro-4,5-dimethyl-2-(2-   65894-83-9
methyl propyl)thiazole
Dihydrojasmone                   1128-08-1
Dihydroxyacetophenone            28631-86-9
1,1-Dimethoxy-3,7-dimethyl-7-    141-92-4
octanol
3,7-Dimethyl-1,6-octadien-3-yl   126-64-7
benzoate
3,7-Dimethyl-1,6-octadien-3-yl   78-36-4
butyrate
3,7-Dimethyl-1,6-octadien-3-yl   78-35-3
isobutyrate
3,7-Dimethyl-1,6-octadien-3-yl   144-39-8
propanoate
cis-3,7-Dimethyl-2,6-octadien-1- 2345-24-6
yl 2-methyl propanoate
2,4-Dimethyl-3-cyclohexene-1-    68039-49-6
carboxaldehyde
2,6-Dimethyl-5-hepten-1-al       106-72-9
trans,cis-2,6-Dodecadien-1-al    21662-13-5
Eglantal                         26643-91-4
Ethyl E-2-bexenoate              27829-72-7
Ethyl tiglate                    5837-78-5
Ethyl trans-4-decenoate          76649-16-6
5-Ethyl-4-hydroxy-2-methyl-      27538-09-6
3[2H]furanone
2-Ethyl-4-methyl thiazole        15679-12-6
2,6,10-Trimethyl-2,6,10-         762-29-8
pentadecatrien-14-one
Guaiacyl phenyl acetate          4112-89-4
3-Hepten-2-one                   1119-44-4
trans-2-Hexen-1-ol               2305-21-7
Trans-2-hexenyl butyrate         53398-83-7
Hexyl phenylacetate              5421-17-0
Hexyl propionate                 2445-76-3
Hydroxycitronellol               107-74-4
Isobutyl 2-butenoate             589-66-2
Isobutyl salicylate              87-19-4
Isodihydro lavandulal            35158-25-9
Isoeugenyl phenyl acetate        120-24-1
Isopropyl alpha-methylcrotonate  1733-25-1
p-Menth-1-en-8-yl propionate     80-27-3
Menthalactone                    13341-72-5
3-Methoxy-p-cymene               1076-56-8
Methyl 4-methyl pentanoate       2412-80-8
alpha-Methyl benzyl formate      7775-38-4
2-Methylbutyl 2-methylbutanoate  2445-78-5
Methyl c-2-octenoate             2396-85-2
p-Methyl hydratropaldehyde       99-72-9
3-(5-Methyl-2-furyl)butanal      31704-80-0
Nerol oxide                      1786-08-9
trans,cis-2,6-Nonadien-1-ol      7786-44-9
trans-2-Octen-1-yl acetate       3913-80-2
3-Octen-2-one                    1669-44-9
2-Phenyl-2-butenal               4411-89-6
2-Propionylthiazole              43039-98-1
1-Hydroxy-2-butanone             5077-67-8
2-Butanone, 3-hydroxy-, (+−)-    52217-02-4
Thiazole, 2,5-dimethyl-          4175-66-0
Butanethioic acid, S-methyl      2432-51-1
ester
2,4-Hexadienoic acid, methyl     689-89-4
ester, (E,E)-
Benzeneacetaldehyde, 4-          104-09-6
methyl-
Bicyclo[4.1.0]hept-3-ene, 3,7,7- 498-15-7
trimethyl-, (1S)-
Ethyl 3-hexenoate                2396-83-0
1H-Pyrrole, 1-(2-furanylmethyl)- 1438-94-4
6-Octenal, 3,7-dimethyl-, (R)-   2385-77-5
Ethanethioic acid, S-(2-         13678-68-7
furanylmethyl) ester
6-Octen-1-ol, 3,7-dimethyl-, (R)- 1117-61-9
6-Octen-1-ol, 3,7-dimethyl-, (S)- 7540-51-4
DL-Tetrohydrofurfuryl propionate 637-65-0
Benzenepentanol                  10521-91-2
Cyclohexaneethanol, acetate      21722-83-8
Benzyl isobutyl ketone           5349-62-2
Butanoic acid, 3-oxo-,           5396-89-4
phenylmethyl ester
1,2-Ethanediamine, N,N′-         140-28-3
bis(phenylmethyl)-
2-Ethyl-3-hydroxy-4-pyrone       1110651
Dicyclohexyl disulfide           2550-40-5
Tetrahydrofurfuryl butyrate      2217-33-6
Thujone                          546-80-5
Benzyl alcohol, alpha-methyl-,   3460-44-4
butyrate
Citronellyl tiglate              24717-85-9
Lacitol                          585-86-4
Nonivamide                       244-46-4
2-Acetoxy-3-butanone             4906-24-5
3-Acetyl-2,5-dimethylthiophene   230378
3-Acetyl-2-5dimethylfuran        10599-70-9
4-Acetyl-6-t-butyl-1,1-          13171-00-1
dimethylindan
Allyl 2-furoate                  4208-49-5
Allyl sorbate                    7493-75-6
Allyl thiopropionate             41820-22-8
Allyl tiglate                    7493-71-2
Amylcyclohexyl acetate           67874-72-0
Benzaldehyde glyceryl acetal     1319-88-6
Benzaldehyde propylene glycol    2568-25-4
acetal
Bornyl isovalerate               76-50-6
1,3-Butanedithiol                24330-52-7
2,3-Butanedithiol                4532-64-3
Butyl cinnamic aldehyde          7492-44-6
Cinnamyl benzoate                5320-75-2
Citral ethylene glycol acetal    66408-78-4
Citronellyloxyacetaldehyde       7492-67-3
Citrionellyl phenylacetate       139-70-8
Cyclohexyl isovalerate           7774-44-9
Decalactone                      5579-78-2
2,5-Dimethyl-4-methoxy-3(2H)-    4077-47-8
furanone
6,10-Dimethyl-9-undecen-2-one    4433-36-7
2-Ethoxythiazole                 15679-19-3
Ethyl 2-mercaptopropionate       19788-49-9
Ethyl 2-methyl-4-pentenoate      53399-81-8
Ethyl 3-(2-furyl)propanoate      94278-27-0
Ethyl cyclohexanepropionate      10094-36-7
Ethyl (p-tolyloxy)acetate        67028-40-4
3-Ethyl-2-hydroxy-2-             21835-01-8
cyclopenten-1-one
Ethylene brassylate              105-95-3
2-Ethylfenchol                   18368-91-7
Furfuryl 3-methylbutanoate       13678-60-9
Furfuryl butyrate                623-21-2
Furfuryl isopropyl sulfide       1883-78-9
Furfuryl methyl sulfide          1438-91-1
Furfuryl propionate              623-19-8
Furfuryl thiopropionate          59020-85-8
Geranyl acetoacetate             10032-00-5
Geranyl benzoate                 94-48-4
Geranyl isovalerate              109-20-6
delta-Hexalactone                823-22-3
trans-3-Hexenal                  69112-21-6
cis-3-Hexenyl anthranilate       65405-76-7
trans-2-Hexenyl propionate       53398-80-4
5-(cis-3-Hexenyl) dihydro-5-     70851-61-5
methyl-2(3H)furanone
Hexyl 2-formate                  39251-86-0
Hexyl crotonate                  19089-92-0
Hexyl formate                    629-33-4
Isoamyl 3-(2-furyl)propionate    7779-67-1
Isoamyl pyruvate                 7779-72-8
Isobutyl furylpropionate         105-01-1
Isohexenyl cyclohexenyl          37677-14-8
carboxaldehyde
p-Isopropyl phenylacetaldehyde   4395-92-0
Linalyl cinnamate                78-37-5
Linalyl formate                  115-99-1
Linalyl isovalerate              1118-27-0
Linalyl phenylacetate            7143-69-3
Maltol isobutryrate              65416-14-0
Methyl 2-methylpentanoate        2177-77-7
Methyl 3-hydroxyhexanoate        21188-58-9
Methyl 3-nonenoate               13481-87-3
Methyl furfuryl disulfide        57500-00-2
Methyl p-tert-butylphenylacetate 3549-23-3
3-Methyl-1,2-cyclohexanedione    3008-43-3
alpha-Methylanisalacetone        104-27-8
2-Methylbutyl isovalerate        2445-77-4
4-Methylnonanoic acid            45019-28-1
4-Methyloctanoic acid            54947-74-9
2-Methyltetrahydrothiophen-3-    13679-85-1
one
3-(Methylthio)butanal            16630-52-7
4-(Methylthio)butanol            20582-85-8
4-Methylthio-2-butanone          34047-39-7
4-Methylthio-4-methyl-2-         23550-40-5
pentanone
Neryl butyrate                   999-40-6
Neryl formate                    2142-94-1
Neryl isovalerate                3915-83-1
Octahydrocoumarin                4430-31-3
Phenethyl 2-furoate              7149-32-8
1-Phenyl-2-pentanol              705-73-7
Phenylacetaldehyde               68345-22-2
diisobutylacetal
Phenylacetaldehyde glyceryl      29895-73-6
acetal
2-(3-Phenylpropyl)pyridine       2110-18-1
Propyl phenylacetate             4606-15-9
Pyrazineethanethiol              35250-53-4
Ethyl 2-methyl pentanoate        39255-32-8
Methyl 2,4-decadienoate          4493-42-9
alpha-Isomethyl ionone           127-51-5
5-Methyl hexanoic acid           628-46-6
Ethyl 3-methyl pentanoate        5870-68-8
Ethyl 2-methyl-3,4-              60523-21-9
pentadienoate
3-Nonen-2-one                    14309-57-0
5-Methyl-3-hexen-2-one           5166-53-0
Maltol propionate                68555-63-5
2-Methyl-3-(2-furyl) acrolein    874-66-8
Ethyl 3(2-furyl)propanoate       10031-90-0
2-Phenyl-3-(2-furyl)-propenal    57568-60-2
4-Methyl-2-pentyl-1,3-dioxolane  1599-49-1
2-Ethyl-4,5-dimethyl oxazole     53833-30-0
Isobornyl isovalerate            7779-73-9
Theophylline-7-acetic acid       652-37-9
Ethyl trans-2-octenoate          7367-82-0
DL-Arginine                      7200-25-1
Allyl Crotonate                  20474-93-5
2-Methoxystyrene                 612-15-7
Magnesium Fumarate               7704-71-4
2-Propionylpyrrole               1073-26-3
2-methyl-1,3-dithiolane          5616-51-3
2-ethyl-5-methyl pyrazine        13360-64-0
2-methyl-3-(dimercaptomethyl)-   65505-17-1
furan
Magnesium gluconate              3632-91-5
Manganese gluconate              6485-39-8
Erythritol                       149-32-6
D-Arabinose                      28697-53-2
D-Galactose                      59-23-4
D-(+)-Mannose                    3458-28-4
Sorbitol                         50-70-4
Aspartame                        22839-47-0
Cyclamic Acid                    100-88-9
Dulcin                           150-69-6
Glucose-1-phosphate              29732-59-0
Dipotassium Salt
L-(+)-Arabinose                  87-72-9
Fructose-6-Phosphate             643-13-0
D-Maltose Monohydrate            6363-53-7
Ribose                           24259-59-4
Fructose 1,6-Diphosphate         26177-85-5
Disodium Salt
Saccharin sodium, dihydrate      6155-57-3
1,2-Benzisothiazol-3(2H)-one     6485-34-3
1,1-dioxide, calcium salt
1,2-Benzisothiazolin-3-one       10332-51-1
1,1-dioxide, potassium salt
zeranol                          26538-44-3
beta-D-fructopyranose            7660-25-5
D-fructose, 1,6-bisphosphate     488-69-7
Ribose 5-phosphate               4300-28-1
Arabinose                        147-81-9
Saccharin, sodium salt hydrate   82385-42-0
Maltitol                         585-88-6
D-Fructose 1-phosphate           15978-08-2
D-Sorbitol 6-phosphate           108392-12-
alpha-D-Xylose                   31178-70-8
Inositol 1-phosphate             573-35-3

Table 3 sets forth the group comprising molecules believed at present to be suitable guests. It is contemplated that the guests set forth in the Table may be arranged in subgroups based upon molecular structure and/or physiological effect. Furthermore, the foregoing list is intended to provide a written description of any sublist that omits one or more guests.

TABLE 3
Name                             CAS #
Sodium Metabisulfite             7681-57-4
sodium hydrogen phosphate        7558-79-4
Sodium Phosphate Monobasic       7558-80-7
Sodium thiosulfate               7772-98-71
Orthoboric acid                  10043-35-3
Diethanolamine                   111-42-2
Benzaldehyde                     100-52-7
Sorbic acid                      110-44-1
L-(+) Tartaric Acid              87-69-4
D-mannnitol                      69-65-8
Butyl paraben                    94-26-8
Thymol                           89-83-8
Methyl salicylate                119-36-8
Citric acid                      77-92-9
Creatinine                       60-27-5
Vitamin C                        50-81-7
Benzoic Acid                     65-85-0
Methyl 4-hydroxybenzoate         99-76-3
m-Cresol                         108-39-4
p-Cresol                         106-44-5
Aspirin                          50-78-2
Phenol                           108-95-2
Sucrose                          57-50-1
Potassium citrate, monohydrate   1534146
Sodium acetate                   127-09-3
Lactic acid                      50-21-5
Propionic acid, sodium salt      65-85
Benzyl alcohol                   100-51-6
Phenethyl alcohol                60-12-8
Cholesterol                      57-88-5
D-Glucose                        50-99-7
Sorbitol                         50-70-4
Aspartame                        22839-47-0
Saacharin                        81-07-2
2,6-Di-tert-Butyl-p-Cresol       128-37-0
4-Chloro-3-methylphenol          59-50-7
glycerin                         56-81-5
Propyl paraben                   94-13-3
fumaric acid                     110-17-8
dabco                            280-57-9
p-Phenylenediamine               106-50-3
Anethole                         4180-23-8
propyl gallate                   121-79-9
L-monosodium glutamate           142-47-2
Butylated hydroxyanisole         25013-16-5
Cyclohexanol, 5-methyl1-2-(1-    89-78-1
methylethyl)-, (1alpha, 2beta,
5alpha)-
Alpha-Thioglycerol               96-27-5
Sodium dehydroacetate            4418-26-2
Ethyl 4-hydroxybenzoate          120-47-8
Ethyl Vanillin                   121-32-4
Triacetin                        102-76-1
Potassium sorbate                590-00-1
Triethyl citrate                 77-93-0
(S)-(+)-Arginine                 74-79-3
Glycine                          56-40-6
(S)-(−)_Histidine                71-00-1
(S)-(+)-Lysine                   56-87-1
Quinone                          106-51-4
Naphthalene, 2-ethoxy-           93-18-5
Methanesulfonic Acid             75-75-2
DL-Tartaric Acid                 133-37-9
Cyclamic acid                    100-88-9
(S)-(−)-Phenylalanine            63-91-2
(S)-(−)-Tyrosine                 60-18-4
Carvone                          99-49-0
Ethyl butynate                   105-54-4
6-Methyl-5-hepten-2-one          110-93-0
Ethyl acetoacetate               141-97-9
Methyl benzoate                  93-58-3
Phenylacetic Acid                103-82-2
Adipic acid                      124-04-9
Ethyl benzoate                   93-89-0
Benzyl benzoate                  120-51-4
Pyruvic acid                     127-17-3
Succinic acid                    110-15-6
Indole                           120-72-9
Methyl anthranilate              134-20-3
Diethyl malonate                 105-53-3
Niacin                           59-67-6
Meso-inositol                    87-89-8
4-Aminobenzoic acid              150-13-0
Anisole                          100-66-3
Urea                             57-13-6
Pyrrolidine                      123-75-1
Cyclopentanone                   120-92-3
Acetic anhydride                 108-24-7
Benzophenone                     119-61-9
D-(−)-Fructose                   57-48-7
D-(+)-Xylose                     58-86-6
o-Methoxybenzoic Acid            579-75-9
linalool                         78-70-6
ethyl isovalerate                108-64-5
1,1′-Azobisformamide             123-77-3
6-Methylcoumarin                 92-48-8
acetoin                          513-86-0
alpha-Phellandrene               99-83-2
Cymene                           99-87-6
Dimethyl Succinate               106-65-0
p-Anisaldehyde                   123-11-5
Phenyl ether                     101-84-8
Tetrahydro-2-furanmethanol       97-99-4
Valeric Acid                     109-52-4
3,4-xylenol                      95-65-8
1,1-diethoxyethane               105-57-7
ethyl butyraldehyde              97-96-1
Ethyl crotonate                  623-70-1
ethyl isobutyrate                97-62-1
methyl isovalerate               556-24-1
methyl propionate                554-12-1
methyl valeraldehyde             123-15-9
4-(2,6,6-Trimethyl-2-cyclobexen- 127-41-3
1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-            14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Maleic acid                      110-16-7
3-Methylbutanoic acid            503-74-2
L-Glutamic Acid                  56-86-0
D-limonene                       5989-27-5
1-Phenyl-1-propanol              93-54-9
2-Hydroxyacetophenone            118-93-4
2,4-Dihydroybenzoic Acid         89-86-1
2-Phenyl-1-propanol              1123-85-9
3-Phenylpropionic Acid           501-52-0
4-Ethoxyphenol                   622-62-8
Alpha-Terpineol                  98-55-5
Benzaldehyde Dimethylacetal      1125-88-8
Benzyl Ether                     103-50-4
Benzyl Formate                   104-57-4
Benzyl Salicylate                118-58-1
Cinnamyl Alcohol                 104-54-1
D-(+)-Glucono-1,5-lactone        4253-68-3
D-Isoascorbic Acid               89-65-6
2,3-Naphtalenediol               92-44-4
Diethyl Succinate                123-25-1
Ethyl 2-Aminobenzoate            87-25-2
Ethyl Cinnamate                  103-36-6
Ethyl Phenylacetate              101-97-3
Ethyl Salicylate                 118-61-6
gamma-Valerolactone              108-29-2
Hydroquinone Dimethyl Ether      150-78-7
Isocaproic Acid                  646-07-01
Isoeugenol                       97-54-1
Isopropyl Benzoate               939-48-0
L-(+)-Isoleucine                 73-32-5
L-Malic acid                     97-67-6
L-2-Aminopropionic Acid          56-41-7
L-Carnitine                      541-15-1
L-Glutamine                      56-85-9
L-Hydroxyproline                 51-35-4
L-Proline                        147-85-3
L-Serine                         56-45-1
L-Threonine                      72-19-5
L-Valine                         72-18-4
Phenoxyacetic Acid               122-59-8
Veratrole                        91-16-7
2-Ethylbutyric acid              88-09-5
2-Methylpyrazine                 109-08-0
o-methoxybenzaldehyde            135-02-4
L-Leucine                        61-90-5
L-Asparagine                     70-47-3
propiophenone                    93-55-0
5-isopropyl-2-methyl-phenol      499-75-2
Xylitol                          87-99-0
ethyl 4-oxopentanoate            539-88-8
methyl cinnamate                 103-26-4
cumic alcohol                    536-60-7
methyl 2-naphthyl ketone         93-08-3
1-methyl-4-(1-methylethyl)-      99-85-4
1,4-Cyclobexadiene
en-ethylene diamine
Caffeine                         58-08-2
5-methylfurfural                 620-02-0
furfuryl acetate                 623-17-6
terpinen-4-ol                    10482-56-1
phenylethanal                    122-78-1
4′-Methoxyacetophenone           100-06-01
D-Fenchone                       4695-62-9
1-Methoxy-4-methylbenzene        104-93-8
o-methylanisole                  578-58-5
Acetylacetaldehyde dimethyl      5436-21-5
acetal
p-methylacetophenone             122-00-9
Methyl phenylacetate             101-41-7
4-Ethoxybenzaldehyde             10031-82-0
p-tolyl acetate                  140-39-6
2,6-Dimethoxyphenol              91-10-1
Methyl 2-methoxybenzoate         606-45-1
alpha-methicinnamaldehyde        101-39-3
2-methoxycinnamaldehyde          60125-24-8
Potassium bicarbonate            298-14-6
piperonyl acetate                326-61-4
2,3-hexanedione                  3848-24-6
furfural acetone                 623-15-4
trans beta-(2-furyl)acrolein     623-30-3
carveol                          99-48-9
Methyl nicotinate                93-60-7
Ethyl benzoylacetate             94-02-0
Methyl 4-methoxybenzoate         121-98-2
Luvulinic acid                   123-76-2
m-Dimethoxybenzene               151-10-0
2-acetylpyridine                 1122-62-9
tetramethyl-pyrazine             1124-11-4
2,3-dimethyl-pyrazine            5910-89-4
trimethyl-pyrazine               14667-55-1
2-ethyl-3-methyl-pyrazine        15707-23-0
5-Methyl-3H-furan-2-one          591-12-8
2-Methoxy-4-methylphenol         93-51-6
piperazine                       110-85-0
2-Methoxy-4-propylphenol         2785-87-7
Naphthalene, 2-(2-               2173-57-1
methylpropoxy)-
2-Acetyl-1-methylpyrrole         932-16-1
3,3-Dimethylacrylic acid         541-47-9
Ethyl sorbate                    2396-84-1
4-(4-Hydroxyphenyl)-2-butanone   5471-51-2
4-Methoxyphenylacetone           122-84-9
(−)-Myrtenal                     564-94-3
3-Phenylpropionaldehyde          104-53-0
1-Phenylethyl propionate         120-45-6
2-Methyltetrahydrofuran-3-one    3188-00-9
Cinnamyl acetate                 103-54-8
Styrallyl acetate                93-92-5
Ethyl 4-methoxybenzoate          94-30-4
Benzyl propionate                122-63-4
Phenylpyruvate                   156-06-9
furaneol                         3658-77-3
methyl 2-methylbutanoate         868-57-5
Benzeneacetaldehyde, alpha-      93-53-8
methyl-Dimethyl anthranilate     85-91-6
1,1-Dimethoxy-2-phenylpropane    90-87-9
4-hexanolide                     695-06-7
Dimethylbenzylcarbinyl acetate   151-05-3
Benzyl isobutyrate               103-28-6
Acetyl isoeugenol                93-29-8
2-Acetyl-5-methyl furan          1193-79-9
Alpha-methyl-p-                  103-95-7
isopropylphenylpropanaldehyde    104-62-1
Benzylcarbinyl formate
p-Cresyl alpha-toluate           101-94-0
Potassium bisulfate              7646-93-7
Potassium carbonate              584-08-7
Potassium chloride               7447-40-7
Potassium hydroxide              1310-58-3
Ethyl tiglate                    5837-78-5
Nerol oxide                      1786-08-9
DL-Tetrohydrofurfuryl propionate 637-65-0
Benzaldehyde propylene glycol    2568-25-4
acetal
2-Methyl-3-(2-furyl) acrolein    874-66-8
vanillin                         121-35-5
Cholic acid                      81-25-4
R-Carvone                        6485-40-1
Potassium nitrate                7757-79-1
Potassium permanganate           7722-64-7
Potassium persulfate             7727-21-1
Potassium phosphate, dibasic     2139900
potassium Phosphate              7778-77-0
Monobasic
Potassium sulfate                7778-80-5
Sodium bicarbonate               144-55-8
Sodium bisulfite                 7631-90-5
Sodium carbonate                 497-19-8
Sodium chloride                  7647-14-5
Sodium dithionite                7775-14-6
Sodium hydroxide                 1310-73-2
Sodium nitrite                   7632-00-0
Sodium Pyrophosphate             7722-88-5
Sodium sulfate                   7757-82-6
Sodium sulfite                   7757-83-7
Sodium thiocyanate               540-72-7
Calcium Carbonate                471-34-1
Calcium chloride                 10043-52-4
Calcium gluconate                299-28-5
Calcium hydroxide                1305-62-0
Calcium phosphate, dibasic       7757-93-9
Calcium sulfate                  7778-18-9
N-methyl-D-glucamine             6284-40-8
Calcium oxide                    1305-78-8
Calcium Phosphate Monobasic      7758-23-8
Magnesium chloride               7791-18-6
hexahydrate
Magnesium sulfate                7487-88-9
Magnesium Sulfate                10034-99-8
Heptahydrate
Aluminum chloride hexahydrate    7784-13-6
aluminum nitrate nonahydrate     7784-27-2
Aluminum potassium sulfate,      7784-24-9
dodecabydrate
Aluminum sulfate                 7784-31-8
octadecahydrate
(S)-(−)-Cysteine                 52-90-4
p-Toleunesulfonic Acid           104-15-4
Potassium bitartrate             868-14-4
DL-aspartic acid                 617-45-8
p-Dimethylaminobenzaldehyde      100-10-7
Sodium salicylate                54-21-7
Benzoin                          119-53-9
Sodium dodecyl sulfate           151-21-3
L-Menthol                        2216-51-5
Tiron                            149-45-1
Riboflavin                       83-88-5
Sodium Acelate Trihydrate        6131-90-4
Disodium Succinate               6106-21-4
Hexahydrate
Disodium                         6381-92-6
ethylenediaminetetraacetate
dihydrate
sodium citrate, dihydrate        1545801
Sodium potassium tartrate,       6381-59-5
tetrahydrate
L-(+)-Arginine                   1119-34-2
monohydrochloride
Ethylenediamine                  333-18-6
dihydrochloride
Sodium formate                   141-53-7
Sodium acetate                   127-09-3
Potassium acetate                127-08-2
Ammonium citrate                 3012-65-5
Ammonium bicarbonate             1066-33-7
Ammonium chloride                12125-02-9
Ammonium nitrate                 6484-52-2
Ammonium persulfate              7727-54-0
Ammonium sulfate                 7783-20-2
Zinc chloride                    7646-85-7
Sulfuric acid, zinc salt         7446-20-0
(1:1), heptahydrate
Sodium Tripolyphosphate          7758-29-4
ammonium henzoate                1863-63-4
ammonium bisulfite               10192-30-0
1,5-Naphthalenedisulfonic Acid   1655-29-4
Disodium Salt
4-Hydroxybenzoic Acid            99-96-7
Diphenylacetic Acid              117-34-0
Glutaric Acid                    110-94-1
L-(−)-Fucose                     2438-80-4
L-Cysteine Hydrochloride         52-89-1
L-Histidine Hycrochloride        1880304
Monohydrate
o-Toluic Acid                    118-90-1
Pivalic Acid                     75-98-9
Pyruvic Acid Sodium Salt         113-24-6
Potassium bromide                2139626
Sodium Dithionate Dihydrate      7631-94-9
Sodium Malonate                  141-95-7
Trisodium Citrate                68-04-2
Potassium Sodium Tartrate        304-59-6
Potassium Citrate                866-84-2
D-Maltose Monohydrate            6363-53-7
Cyclohexaamylose                 10016-20-3
Dodecyl sulfate, lithium salt    2044-56-6
Manganese chloride               2145076
methyl-urea                      598-50-5
beta-Cyclodextrin                7585-39-9
Triphosphoric acid,              13845-36-8
pentapotassium salt
Glycine ethyl ester              623-33-6
hydrochloride
L-Histidine methyl ester         7389-87-9
dihydrochloride
L-Leucine methyl ester           7517-19-3
hydrochloride
D-Lysine hydrochloride           7274-88-6
2-Naphthalenesulfonic acid       532-02-5
sodium salt
calcium nitrate tetrahydrate     13477-34-4
Vitamin B1                       59-43-8
Zinc Acetate Dihydrate           5970-45-6
Potassium fluoride               7789-23-3
Potassium iodate                 2139718
Potassium iodide                 7681-11-0
Potassium thiocyanate            333-20-0
Sodium bromide                   7647-15-6
Sodium flouride                  7681-49-4
Sodium iodide                    7681-82-5
Sodium nitrate                   7631-99-4
Calcium acetate                  5743-26-0
Trichioracetic acid              76-03-9
Ammonium acetate                 631-61-8
Ammonium flouride                12125-01-8
DL-malic acid                    617-48-1
t-Butyl Alcohol                  75-65-0
beta-Alanine                     107-95-9
(S)-(−)-Tryptophan               73-22-3
Malonic acid                     141-82-2
Phenethylamine                   64-04-0
Salicylylaldehyde                90-02-8
Sodium benzoate                  532-32-1
Mandelic acid                    90-64-2
Calcium pantothenate             137-08-6
Chloracetic Acid                 79-11-8
Ethanol Amine                    141-43-5
Salicylic acid                   69-72-7
Saccharin sodium                 128-44-9
Thiamine hydrochloride           67-03-8
2,2′-Oxybisethanol               111-46-6
Resorcinol                       108-46-3
2-Amino-2-(hydroxymethyl)-1,3-   77-86-1
propanediol
2,5-Dimethylphenol               95-87-4
Ammonium Phosphate               7722-76-1
Monobasic
1,3-Butanediol                   107-88-0
Glycolic Acid                    79-14-1
Sodium gluconate                 527-07-1
Terephthalic Acid                100-21-0
L-Ascorbic Acid Sodium Salt      134-03-2
3-Acetyl-6-methyl-2,4-           520-45-6
pyrandione
Calcium Acetate                  62-54-4
Nicotinamide                     98-92-0
1-Hydroxy-2-napthoic Acid        86-48-6
2-Isopropylphenol                88-69-7
4-Aminosalicyclic Acid           65-49-6
Calcium Glycerophosphate         27214-00-2
Erythorbic Acid Sodium Salt      7378-23-6
Gluconic Acid Potassium Salt     299-27-4
Orotic Acid                      65-86-1
p-Anise Alcohol                  105-13-5
Acetic anhydride                 108-24-7
Benzophenone                     119-61-9
D-(−)-Fructose                   57-48-7
D-(+)-Xylose                     58-86-6
o-Methoxybenzoic Acid            579-75-9
linalool                         78-70-6
ethyl isovalerate                108-64-5
1,1′-Azobisformamide             123-77-3
6-Methylcoumarin                 92-48-8
acetoin                          513-86-0
alpha-Phellandrene               99-83-2
Cymene                           99-87-6
Dimethyl Succinate               106-65-0
p-Anisaldehyde                   123-11-5
Phenyl ether                     101-84-8
Tetxahydro-2-furanmethanol       97-99-4
Valeric Acid                     109-52-4
3,4-xylenol                      95-65-8
1,1-diethoxyethane               105-57-7
ethyl butyraldehyde              97-96-1
Ethyl crotonate                  623-70-1
ethyl isobutyrate                97-62-1
methyl isovalerate               556-24-1
methyl propionate                554-12-1
methyl valeraldehyde             123-15-9
4-(2,6,6-Trimethyl-2-            127-41-3
cyclohexen-1-yl)-3-buten-2-one
4-(2,6,6-trimethyl-1-            14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Maleic acid                      110-16-7
3-Methylbutanoic acid            503-74-2
L-Glutamic Acid                  56-86-0
D-limonene                       5989-27-5
1-Phenyl-1-propanol              93-54-9
2′-Hydroxyacetophenone           118-93-4
2,4-Dihydroxybenzoic Acid        89-86-1
2-Phenyl-1-propanol              1123-85-9
3-Phenylpropionic Acid           501-52-0
4-Ethoxyphenol                   622-62-8
Alpha-Terpineol                  98-55-5
Bcnzaldehyde Dimethylacetal      1125-88-8
Benzyl Ether                     103-50-4
Benzyl Formate                   104-57-4
Benzyl Salicylate                118-58-1
Cinnamyl Alcohol                 104-54-1
D-(+)-Glucono-1,5-lactone        4253-68-3
D-Isoascorbic Acid               89-65-6
2,3-Naphthalenediol              92-44-4
Diethyl Succinate                123-25-1
Ethyl 2-Aminobenzoate            87-25-2
Ethyl Cinnamate                  103-36-6
Ethyl Phenylacetate              101-97-3
Ethyl Salicylate                 118-61-6
gamma-Valenolactone              108-29-2
Hydroquinone Dimethyl Ether      150-78-7
Isocaproic Acid                  646-07-1
Isoeugenol                       97-54-1
Isopropyl Benzoate               939-48-0
L-(+)-Isoleucine                 73-32-5
L-Malic acid                     97-67-6
L-2-Aminopropionic Acid          56-41-7
L-Carnitine                      541-15-1
L-Glutamine                      56-85-9
L-Hydroxyproline                 51-35-4
L-Proline                        147-85-3
L-Serine                         56-45-1
L-Threonine                      72-19-5
L-Valine                         72-18-4
Phenozyacetic Acid               122-59-8
Veratrole                        91-16-7
2-Ethylbutyric acid              88-09-5
2-Methylpyrazine                 109-08-0
o-methoxybenzaldehyde            135-02-4
L-Leucine                        61-90-5
L-Asparagine                     70-47-3
propiophenone                    93-55-0
5-isopropyl-2-methyl-phenol      499-75-2
Xylitol                          87-99-0
ethyl 4-oxopentanoate            539-88-8
methyl cinnamate                 103-26-4
cumic alcohol                    536-60-7
methyl 2-naphthyl ketone         93-08-3
1-methyl-4-(1-methylethyl)-      99-85-4
1,4-Cyclohexadiene
en-ethylene diamine
Caffeine                         58-08-2
5-methylfurfural                 620-02-0
furfuryl acetate                 623-17-6
terpinen-4-ol                    10482-56-1
phenylethanal                    122-78-1
4′-Methoxyacetophenone           100-06-1
D-Fenchone                       4695-62-9
1-Methoxy-4-methylbenzene        104-93-8
o-methylanisole                  578-58-5
Acetylacetaldehyde dimethyl      5436-21-5
acetal
p-methylacetophenone             122-00-9
Methyl phenylacetate             101-41-7
4-Ethoxybenzaldehydc             10031-82-0
p-tolyl acetate                  140-39-6
2,6-Dimethoxyphenol              91-10-1
Methyl 2-methoxybenzoate         606-45-1
alpha-methylcinnamaldehyde       101-39-3
2-methoxycinnamaldehyde          60125-24-8
Potassium bicarbonate            298-14-6
piperonyl acetate                326-61-4
2,3-hexanedione                  3848-24-6
furfural acetone                 623-15-4
trans beta-(2-furyl)acrolein     623-30-3
carveol                          99-48-9
Methyl nicotinate                93-60-7
Ethyl benzoylacetate             94-02-0
Methyl 4-methoxybenzoate         121-98-2
Levulinic acid                   123-76-2
m-Dimethoxybenzene               151-10-0
2-acetylpyridine                 1122-62-9
tetramethyl-pyrazine             1124-11-4
2,3-dimethyl-pyzazine            5910-89-4
trimethyl-pyrazine               14667-55-1
2-ethyl-3-methyl-pyrazine        15707-23-0
5-Methyl-3H-furan-2-one          591-12-8
2-Methoxy-4-methylphenol         93-51-6
piperazine                       110-85-0
2-Methoxy-4-propylphenol         2785-87-7
Naphthalene,2-(2-                2173-57-1
methylpropoxy)-
2-Acetyl-1-methylpyrrole         932-16-1
3,3-Dimethylacrylic acid         541-47-9
Ethyl sorbate                    2396-84-1
4-(4-Hydroxyphenyl)-2-butanone   5471-51-2
4-Methoxyphenylacetone           122-84-9
(−)-Myrtenal                     564-94-3
3-Phenylpropionaldehyde          104-53-0
1-Phenylethyl propionate         120-45-6
2-Methyltetrahydrofuran-3-one    3188-00-9
Cinnamyl acetate                 103-54-8
Styrallyl acetate                93-92-5
Ethyl 4-methoxybenzoate          94-30-4
Benzyl propionate                122-63-4
Phenylpyruvate                   156-06-9
furaneol                         3658-77-3
methyl 2-methylbutanoate         868-57-5
Benzeneacetaldehyde, alpha-      93-53-8
methyl-
Dimethyl anthranilate            85-91-6
1,1-Dimethoxy-2-phenylpropane    90-87-9
4-hexanolide                     695-06-7
Dimethylbenzylcarbinyl acetate   151-05-3
Potassium Benzoate               582-25-2
Taurine                          107-35-7
Thiamine Nitrate                 532-43-4
3,3,5-Trimethyl-1-cyclohexanol   116-02-9
tert-Butylhydroquinone           1948-33-0
Sulfosalicyclic acid             97-05-2
Gallic acid                      149-91-7
L-borneol                        464-45-9
Isoborneol                       124-76-5
2,5-Dihydroxybenzoic acid,       490-79-9
Gentisic acid
5-hydroxy-6-methyl-3,4-          65-23-6
pyridimedimethanol
Naphthalene-2-sulfonic acid      120-18-3
Ethanesulfonic acid, 2-hydroxy-, 1562-00-1
monosodium salt
Panoic acid                      130-85-8
2,4-Dimethylphenol               105-67-9
3,5-Dihydroxyacetophenone        51863-60-6
Eugenol                          97-53-0
a-Butyric Acid                   107-92-6
Hydroquinone                     123-31-9
Propionic Acid                   79-09-4
meta-Phenylanediamine            108-45-2
Oxalic Acid                      144-62-7
n-Hexanoic Acid                  142-62-1
2-Furancarboxylic Acid           88-14-2
4′-Nitroacetanilide              104-04-1
D-(−)-Tartaric Acid              147-71-7
p-Acetamidobenzoic Acid          556-08-1
Galactaric acid                  526-99-8
D-glucoronate                    1700908
Lactobionic acid                 96-82-2
p-Formylacetanilide              122-85-0
2-Mercaptobenzoic acid           147-93-3
Propanioc acid, 2-hydroxy-,      28305-25-1
calcium salt (2:1), (S)-
D(+)-10-Camphorsulfonic acid     3144-16-9
3-Cyclopentylpropionic acid      140-77-2
1R-(−)-Camphorsulfonic acid      35963-20-3
DL-Lysine                        70-54-2
Cinnamic acid                    621-82-9
Triethanolamine                  102-71-6
Acetic Acid                      64-19-7
Dichloroacetic Acid              79-43-6
Diethylamine                     109-89-7
Diethylamineothanol              100-37-8
N-(2-Hydroxyethyl)Morpholine     622-40-2
Octanoic Acid                    124-07-2
isobutyric acid                  79-31-2
Anisic Acid                      100-09-4
Betaine                          107-43-7
Enanthoic Acid                   111-14-8
Hippuric Acid                    495-69-2
Tiglic Acid                      80-59-1
Cyclohexanecarboxylic acid       98-89-5
m-Methoxybenzoic acid            586-38-9
D-(+)-Camphoric acid             124-83-4
N-(2-Hydroxyethyl)pyrrolidine    2955-88-6
Sodium Metabisulfite             7681-57-4
sodium hydrogen phosphate        7558-79-4
Sodium Phosphate Monobasic       7558-80-7
Sodium thiosulfate               7772-98-71
Orthoboric acid                  10043-35-3
Diethanolamine                   111-42-2
Benzaldehyde                     100-52-7
Sorbic acid                      110-44-1
L-(+)-Tartaric Acid              87-69-4
D-mannitol                       69-65-8
Butyl paraben                    94-26-8
Thymol                           89-83-8
Methyl salicylate                119-36-8
Citric acid                      77-92-9
Creatinine                       60-27-5
Vitamin C                        50-81-7
Benzoic Acid                     65-85-0
Methyl 4-hydroxybenzoate         99-76-3
m-Cresol                         108-39-4
p-Cresol                         106-44-5
Aspirin                          50-78-2
Phenol                           108-95-2
Sucrose                          57-50-1
Potassium citrate, monohydrate   1534146
Sodium acetate                   127-09-3
Lactic acid                      50-21-5
Propionic acid, sodium salt      65-85
Benzyl alcohol                   100-51-6
Phenethyl alcohol                60-12-8
Cholesterol                      57-88-5
D-Glucosc                        50-99-7
Sorbitol                         50-70-4
Aspartame                        22839-47-0
Saccharin                        81-07-2
2,6-Di-tert-Butyl-p-Crcsol       128-37-0
4-Chloro-3-mcthylphenol          59-50-7
glycerin                         56-81-5
Propyl paraben                   94-13-3
fumaric acid                     110-17-8
dabco                            280-57-9
p-Phenylenediamine               106-50-3
Ancthole                         4180-23-8
propyl gallate                   121-79-9
L-monosodium glutamate           142-47-2
Butylated hydroxyanisole         25013-16-5
Cyclohexanol, 5-mcthyl-2-(1-     89-78-1
methylethyl)-,
(1alpha,2beta,5alpha)-
alpha-Thioglycerol               96-27-5
Sodium dehydroacetate            4418-26-2
Ethyl 4-hydroxybenzoate          120-47-8
Ethyl Vanillin                   121-32-4
Triacetin                        102-76-1
Potassium sorbate                590-00-1
Triethyl citrate                 77-93-0
(S)-(+)-Arginine                 74-79-3
Glycine                          56-40-6
(S)-(−)-Histidine                71-00-1
(S)-(+)-Lysine                   56-87-1
Quinone                          106-51-4
Naphthalene, 2-ethoxy-           93-18-5
Methanesulfonic Acid             75-75-2
DL-Tartaric Acid                 133-37-9
Cyclamic acid                    100-88-9
(S)-(−)-Phenylalanine            63-91-2
(S)-(−)-Tyrosine                 60-18-4
Carvone                          99-49-0
Ethyl butyrate                   105-54-4
6-Methyl-5-hepten-2-one          110-93-0
Ethyl acetoacetate               141-97-9
Methyl benzoate                  93-58-3
Phenylacetic Acid                103-82-2
Adipic acid                      124-04-9
Ethyl benzoate                   93-89-0
Benzyl benzoate                  120-51-4
Pyruvic acid                     127-17-3
Succinic acid                    110-15-6
Indole                           120-72-9
Methyl anthranilate              134-20-3
Diethyl malonate                 105-53-3
Niacin                           59-67-6
Meso-inositol                    87-89-8
4-Aminobenzoic acid              150-13-0
Anisole                          100-66-3
Urea                             57-13-6
Pyriolidinc                      123-75-1
Cyclopentanone                   120-92-3
Benzyl isobutyrate               103-28-6
Acetyl isoeugenol                93-29-8
2-Acetyl-5-methyl furan          1193-79-9
Alpha-methyl-p                   103-95-7
isopropylphenylpropanaldehydc
Bcnzylcarbinyl formate           104-62-1
p-Cresyl alpha-toluate           101-94-0
Potassium bisulfate              7646-93-7
Potassium carbonate              584-08-7
Potassium chloride               7447-40-7
Potassium hydroxide              1310-58-3
Ethyl tiglate                    5837-78-5
Nerol oxide                      1786-08-9
DL-Tetrohydrofurfuryl            637-65-0
propionate
Bcnzaldehyde propylene glycol    2568-25-4
acetal
2-Methyl-3-(2-furyl) acrolein    874-66-8
vanillin                         121-33-5
Cholic acid                      81-25-4
R-Carvone                        6485-40-1
Potassium nitrate                7757-79-1
Potassium permanganate           7722-64-7
Potassium persulfate             7727-21-1
Potassium phosphate, dibasic     2139900
Potassium Phosphate              7778-77-0
Monobasic
Potassium sulfate                7778-80-5
Sodium bicarbonate               144-55-8
Sodium bisulfite                 7631-90-5
Sodium carbonate                 497-19-8
Sodium chloride                  7647-14-5
Sodium dithionite                7775-14-6
Sodium hydroxide                 1310-73-2
Sodium nitrite                   7632-00-0
Sodium Pyrophosphate             7722-88-5
Sodium sulfate                   7757-82-6
Sodium sulfite                   7757-83-7
Sodium thiocyanate               540-72-7
Calcium Carbonate                471-34-1
Calcium chloride                 10043-52-4
Calcium gluconatc                299-28-5
Calcium hydroxide                1305-62-0
Calcium phosphate, dibasic       7757-93-9
Calcium sulfate                  7778-18-9
N-Methyl-D-glucamine             6284-40-8
Calcium oxide                    1305-78-8
Calcium Phosphate Monobasic      7758-23-8
Magnesium chloride               7791-18-6
hexahydratc
Magnesium sulfate                7487-88-9
Magnesium Sulfate                10034-99-8
Heptahydrate
Aluminum chloride hexahydrate    7784-13-6
aluminum nitrate nonahydrate     7784-27-2
Aluminum potassium sulfate,      7784-24-9
dodecahydrate
Aluminum sulfate,                7784-31-8
octadecahydrate
(S)-(−)-Cysteine                 52-90-4
p-Toluenesulfonic Acid           104-15-4
Potassium bitartrate             868-14-4
DL-aspartic acid                 617-45-8
p-Dimethylaminobenzaldehyde      100-10-7
Sodium salicylate                54-21-7
Benzoin                          119-53-9
Sodium dodecyl sulfate           151-21-3
L-Mcnthol                        2216-51-5
Tiron                            149-45-1
Riboflavin                       83-88-5
Sodium Acetate Trihydrate        6131-90-4
Disodium Succinate               6106-21-4
Hexahydrate
Disodium                         6381-92-6
ethylenediaminetetraacetate
dihydrate
sodium citrate, dihydratc        1545801
Sodium potassium tartrate,       6381-59-5
tetrahydate
L-(+)-Arginine                   1119-34-2
monohydrochloride
Ethylenediamine                  333-18-6
dihydrochloride
Sodium formate                   141-53-7
Sodium acetate                   127-09-3
Potassium acetate                127-08-2
Ammonium citrate                 3012-65-5
Ammonium bicarbonate             1066-33-7
Ammonium chloride                12125-02-9
Ammonium nitrate                 6484-52-2
Ammonium persulfate              7727-54-0
Ammonium sulfate                 7783-20-2
Zinc chloride                    7646-85-7
Sulfuric acid, zinc salt         7446-20-0
(1:1), heptahydrate
Sodium Tripolyphosphate          7758-29-4
ammoniuni benzoate               1863-63-4
ammonium bisulfite               10192-30-0
I,5-Naphthalenedisulfonic Acid   1655-29-4
Disodium Salt
4-Hydroxybenzoic Acid            99-96-7
Diphenylacetic Acid              117-34-0
Glutaric Acid                    110-94-1
L-(−)-Fucose                     2438-80-4
L-Cysteine Hydrochloride         52-89-1
L-Histidine Hydrochloride        1880304
Monohydrate
o-Toluic Acid                    118-90-1
Pivalic Acid                     75-98-9
Pyruvic Acid Sodium Salt         113-24-6
Potassium bromide                2139626
Sodium Dithionate Dihydrate      7631-94-9
Sodium Malonate                  141-95-7
Trisodiuin Citrate               68-04-2
Potassium Sodium Tartratc        304-59-6
Potassium Citrate                866-84-2
D-Maltose Monohydrate            6363-53-7
Cyclohexaamylose                 10016-20-3
Dodecyl sulfate, lithium salt    2044-56-6
Manganese chloride               2145076
methyl-urea                      598-50-5
beta-Cyclodextrin                7585-39-9
Triphosphoric acid,              13845-36-8
pentapotassium salt
Glycine ethyl ester              623-33-6
hydrochloride
L-Histidine methyl cster         7389-87-9
dihydrochloride
L-Leucine methyl ester           7517-19-3
hydrochloride
D-Lysinc hydrochloride           7274-88-6
2-Naphthalenesulfonic acid       532-02-5
sodium salt
calcium nitrate tetrahydrate     13477-34-4
Vitamin B1                       59-43-8
Zinc Acetate Dihydrate           5970-45-6
Potassium fluoride               7789-23-3
Potassium iodate                 2139718
Potassium iodide                 7681-11-0
Potassium thiocyanate            333-20-0
Sodium bromide                   7647-15-6
Sodium fluoride                  7681-49-4
Sodium iodide                    7681-82-5
Sodium nitrate                   7631-99-4
Calcium acetate                  5743-26-0
Trichloroacetic acid             76-03-9
Ammonium acetate                 631-61-8
Ammonium fluoride                12125-01-8
DL-malic acid                    617-48-1
t-Butyl Alcohol                  75-65-0
beta-Alanine                     107-95-9
(S)-(−)-Tryptophan               73-22-3
Malonic acid                     141-82-2
Phenethylamine                   64-04-0
Salicylylaldehyde                90-02-8
Sodium benzoate                  532-32-1
Mandelic acid                    90-64-2
Calcium pantothenatc             137-08-6
Chloroacetic Acid                79-11-8
Ethanol Amine                    141-43-5
Salicylic acid                   69-72-7
Saccharin sodium                 128-44-9
Thiamine hydrochloride           67-03-8
2,2′-Oxybisethanol               111-46-6
Resorcinol                       108-46-3
2-Amino-2-(hydroxymcthyl)-1,3-   77-86-1
propanediol
2,5-Dimethylphenol               95-87-4
Ammonium Phosphate               7722-76-1
Monobasic
1,3-Butanediol                   107-88-0
Glycolic Acid                    79-14-1
Sodium Gluconate                 527-07-1
Terephthalic Acid                100-21-0
L-Ascorbic Acid Sodium Salt      134-03-2
3-Acetyl-6-methyl-2,4-           520-45-6
pyrandione
Calcium Acetate                  62-54-4
Nicotinamide                     98-92-0
1-Hydroxy-2-naphthoic Acid       86-48-6
2-Isopropylphenol                88-69-7
4-Aminosalicylic Acid            65-49-6
Calcium Glycerophosphate         27214-00-2
Erythorbic Acid Sodium Salt      7378-23-6
Gluconic Acid Potassium Salt     299-27-4
Orotic Acid                      65-86-1
p-Anise Alcohol                  105-13-5
Potassium Benzoate               582-25-2
Taurine                          107-35-7
Thiaminc Nitrate                 532-43-4
3,3,5-Trimethyl-1-cyclohexanol   116-02-9
tert-Butylhydroquinone           1948-33-0
Sulfosalicylic acid              97-05-2
Gallic acid                      149-91-7
L-borneol                        464-45-9
Isoborneol                       124-76-5
2,5-Dihydroxybenzoic acid,       490-79-9
Gentisic acid
5-hydroxy-6-methyl-3,4-          65-23-6
pyridinedimethanol
Naphthalene-2-sulfonic acid      120-18-3
Ethanesulfonic acid, 2-          1562-00-1
hydroxy-, monosodium salt
Pamoic acid                      130-85-8
2,4-Dimethylphenol               105-67-9
3,5-Dihydroxyacetophenone        51863-60-6
Eugenol                          97-53-0
n-Butyric Acid                   107-92-6
Hydroquinone                     123-31-9
Propionic Acid                   79-09-4
meta-Phenylenediamine            108-45-2
Oxalic Acid                      144-62-7
n-Hexanoic Acid                  142-62-1
2-Furancarboxylic Acid           88-14-2
4′-Nitroacetanilide              104-04-1
D-(−)-Tartaric Acid              147-71-7
p-Acetamidobenzoic Acid          556-08-1
Galactaric acid                  526-99-8
D-glucuronate                    1700908
Lactobionic acid                 96-82-2
p-Formylacetanilide              122-85-0
2-Mcrcaptobenzoic acid           147-93-3
Propanoic acid, 2-hydroxy-,      28305-25-1
calcium salt (2:1), (5)-
D(+)-10-Camphorsulfonic acid     3144-16-9
3-Cyclopentylpropionic acid      140-77-2
1R-(−)-Camphorsulfonic acid      35963-20-3
DL-Lysine                        70-54-2
Cinnamic acid                    621-82-9
Triethanolaminc                  102-71-6
Acetic Acid                      64-19-7
Dichloroacctic Acid              79-43-6
Diethylamine                     109-89-7
Diethylaminoethanol              100-37-8
N-(2-Hydroxyethyl)Morpholine     622-40-2
Octanoic Acid                    124-07-2
isobutyric acid                  79-31-2
Anisic Acid                      100-09-4
Betaine                          107-43-7
Enanthoic Acid                   111-14-8
Hippuric Acid                    495-69-2
Tiglic Acid                      80-59-1
Cyclohexanecarboxylic acid       98-89-5
m-Methoxybenzoic acid            586-38-9
D-(+)-Camphoric acid             124-83-4
N-(2-Hydxoxyethyl)pyrrolidine    2955-88-6
Sodium Metabisulfite             7681-57-4
sodium hydrogen phosphate        7558-79-4
Sodium Phosphate Monobasic       7558-80-7
Sodium thiosulfate               7772-98-71
Orthoboric acid                  10043-35-3
Diethanolamine                   111-42-2
Benzaldehyde                     100-52-7
Sorbic acid                      110-44-1
L-(+)-Tartaric Acid              87-69-4
D-mannitol                       69-65-8
Butyl paraben                    94-26-8
Thymol                           89-83-8
Methyl salicylatc                119-36-8
Citric acid                      77-92-9
Creatinine                       60-27-5
Vitamin C                        50-81-7
Bcnzoic Acid                     65-85-0
Methyl 4-hydroxybenzoate         99-76-3
in-Cresol                        108-39-4
p-Cresol                         106-44-5
Aspirin                          50-78-2
Phenol                           108-95-2
Sucrose                          57-50-1
Potassium citrate, monohydrate   1534146
Sodium acetate                   127-09-3
Lactic acid                      50-21-5
Propionic acid, sodium salt      65-85
Benozyl alcohol                  100-51-6
Phenethyl alcohol                60-12-8
Cholesterol                      57-88-5
D-Glucose                        50-99-7
Sorbitol                         50-70-4
Aspartame                        22839-47-0
Saccharin                        81-07-2
2,6-Di-tert-Butyl-p-Cresol       128-37-0
4-Chloro-3-methylphenol          59-50-7
glycerin                         56-81-5
Propyl paraben                   94-13-3
fumaric acid                     110-17-8
dabco                            280-57-9
p-Phenylenediamine               106-50-3
Anethole                         4180-23-8
propyl gallate                   121-79-9
L-monosodium glutamate           142-47-2
Butylated hydroxyanisole         25013-16-5
Cyclohexanol, 5-methyl-2-(1-     89-78-1
methylethyl)-,
(1alpha, 2beta, 5alpha)-
alpha-Thioglycerol               96-27-5
Sodium dehydroacetate            4418-26-2
Ethyl 4-hydroxybenzoate          120-47-8
Ethyl Vanillin                   121-32-4
Triacetin                        102-76-1
Potassium sorbate                590-00-1
Triethyl citrate                 77-93-0
(S)-(+)-Arginine                 74-79-3
Glycine                          56-40-6
(S)-(−)-Histidine                71-00-1
(S)-(+)-Lysine                   56-87-1
Quinone                          106-51-4
Naphthalene, 2-ethoxy-           93-18-5
Methanesulfonic Acid             75-75-2
DL-Tartaric Acid                 133-37-9
Cyclamic acid                    100-88-9
(S)-(−)-Phenylalanine            63-91-2
(S)-(−)-Tyrosine                 60-18-4
Carvone                          99-49-0
Ethyl butyrate                   105-54-4
6-Methyl-5-hepten-2-one          110-93-0
Ethyl acetoacetate               141-97-9
Methyl benzoate                  93-58-3
Phenylacetic Acid                103-82-2
Adipic acid                      124-04-9
Ethyl benzoate                   93-89-0
Benzyl benzoate                  120-51-4
Pyruvic acid                     127-17-3
Succinic acid                    110-15-6
Indole                           120-72-9
Methyl anthranilate              134-20-3
Diethyl malonate                 105-53-3
Niacin                           59-67-6
Meso-inositol                    87-89-8
4-Aminobenzoic acid              150-13-0
Anisole                          100-66-3
Urea                             57-13-6
Pyrrolidinc                      123-75-1
Cyclopentanone                   120-92-3
Acetic anhydride                 108-24-7
Benzophenone                     119-61-9
D-(−)-Fructose                   57-48-7
D-(+)-Xylose                     58-86-6
o-Methoxybenzoic Acid            579-75-9
linalool                         78-70-6
ethyl isovalerate                108-64-5
1,1′-Azobisformamide             123-77-3
6-Methylcourmarin                92-48-8
acetoin                          513-86-0
alpha-Phellandrene               99-83-2
Cymene                           99-87-6
Dimethyl succinate               106-65-0
p-Anisaldehyde                   123-11-5
Phenyl ether                     101-84-8
Tetrahydro-2-furanmethanol       97-99-4
Valeric Acid                     109-52-4
3,4-xylenol                      95-65-8
1,1-diethoxyethane               105-57-7
ethyl butyraldehyde              97-96-1
Ethyl crotonate                  623-70-1
ethyl isobtyrate                 97-62-1
methyl isovalerate               556-24-1
methyl propionate                554-12-1
methyl valeraldehyde             123-15-9
4-(2,6,6-Trimethyl-2-cyclohexen- 127-41-3
1-yl)-
3-buten-2-one
4-(2,6,6-trimethyl-1-            14901-07-6
cyclohexen-1-yl)-3-buten-2-one
Maleic acid                      110-16-7
3-Methylbutanoic acid            503-74-2
L-Glutamic Acid                  56-86-0
D-limonene                       5989-27-5
1-Penyl-1-proponal               93-54-9
2′-Hydroxyacetophenone           118-93-4
2,4-Dihydroxybenzoic Acid        89-86-1
2-Phenyl-1-propanol              1123-85-9
3-Phenylpropionic Acid           501-52-0
4-Ethoxyphenol                   622-62-8
Alpha-Terpineol                  98-55-5
Bensaldehyde Dimethylacetal      1125-88-8
Benzyl Ether                     103-50-4
Benzyl Formate                   104-57-4
Benzyl Salicylate                118-58-1
Cinnamyl Alcohol                 104-54-1
D-(+)-Glucono-1,5-lactone        4253-68-3
D-Isoascorbic Acid               89-65-6
2,3-Naphthalenediol              92-44-4
Diethyl Succinate                123-25-1
Ethyl 2-Aminobenzoate            87-25-2
Ethyl Cinnamate                  103-36-6
Ethyl Phenylacetate              101-97-3
Ethyl Salicylate                 118-61-6
gamma-Valerolactone              108-29-2
hydroquinone Dimethyl Ether      150-78-7
Isocapriic Acid                  646-07-1
Isoeugenol                       97-54-1
Isopropyl Benzoate               939-48-0
L-(+)-Isoleucine                 73-32-5
L-Malic acid                     97-67-6
L-2-Aminopropionic Acid          56-41-7
L-Carnitine                      541-15-1
L-Glutamine                      56-85-9
L-Hydroxyproline                 51-35-4
L-Proline                        147-85-3
L-Serine                         56-45-1
L-Threonine                      72-19-5
L-Valine                         72-18-4
Phenoxyacetic Acid               122-59-8
Veratrole                        91-16-7
2-Ethylbutyric acid              88-09-5
2-Methylpyyrazine                109-08-0
o-methoxybenzaldehyde            135-02-4
L-Leucine                        61-90-5
L-Asparagine                     70-47-3
propiophenone                    93-55-0
5-isopropyl-2-methyl-phenol      499-75-2
Xylitol                          87-99-0
ethyl 4-oxopentancoate           539-88-8
methyl cinnamate                 103-26-4
cumic alcohol                    536-60-7
methl 2-naphthyl ketone          93-08-3
1-methyl-1-(1-methylethyl)-      99-85-4
1,4-Cyclohexadiene
en-ethylene diamine
Caffeine                         58-08-2
5-methylfurfural                 620-02-0
furfuryl acetate                 623-17-6
terpinen-4-ol                    10482-56-1
phenylethanal                    122-78-1
4′-Methoxyacetophenone           100-06-1
D-Fenchome                       4695-62-9
1-Methoxy-4-methylbenzene        104-93-8
o-methylanisole                  578-58-5
Acetylacetaldehyde dimethyl      5436-21-5
acetal
p-methylacetophenome             122-00-9
Methyl phenylacetate             101-41-7
4-Ethoxybenzaldehyde             10031-82-0
p-tolyl acetate                  140-39-6
2,6-Dimethoxyphenol              91-10-1
Methyl 2-methoxybenzoate         606-45-1
alpha-methylcinnamaldehyde       101-39-3
2-methoxycinnamaldehyde          60125-24-8
Potassium bicarbonate            298-14-6
piperonyl acetate                326-61-4
2,3-hexanedione                  3848-24-6
furfural acetone                 623-15-4
trans beta-(2-furyl)acrolein     623-30-3
carveol                          99-48-9
Methyl nicotinate                93-60-7
Ethyl benzoylacetate             94-02-0
Methyl 4-methoxybenzoate         121-98-2
Levulinic acid                   123-76-2
m-Dimethoxybenzene               151-10-0
2-acetylpyridine                 1122-62-9
tetramethyl-pyrazine             1124-11-4
2,3-dimethyl-pyrazine            5910-89-4
trimethyl-pyrazine               14667-55-1
2-ethyl-3-methyl-pyrazine        15707-23-0
5-Methyl-3H-furan-2-one          591-12-8
2-Methoxy-4-methylphenol         93-51-6
piperazine                       110-85-0
2-Methoxy-4-propylphenol         2785-87-7
Naphthalene,2-(2-                2173-57-1
methylpropoxy)-
2-Acetyl-1-methylpyrrole         932-16-1
3,3-Dimethylacrylic acid         541-47-9
Ethyl sorbate                    2396-84-1
4-(4-Hydroxyphenyl)-2-butanone   5471-51-2
4-Methoxyphenylacetone           122-84-9
(−)-Myrtenal                     564-94-3
3-Phenylpropionaldehyde          104-53-0
1-Phenylethyl propionate         120-45-6
2-Methyltetrahydrofuran-3-one    3188-00-9
Cinnamyl acetate                 103-54-8
Styrallyl acetate                93-92-5
Ethyl 4-methoxybenzoate          94-30-4
Benzyl propionate                122-63-4
Phenylpyruvate                   156-06-9
furaneol                         3658-77-3
methyl 2-methylbutanoate         868-57-5
Benzeneacetaldehyde, alpha-      93-53-8
methyl-
Dimethyl anthranilate            85-91-6
1,1-Dimethoxy-2-phenylpropane    90-87-9
4-hexanolide                     695-06-7
Dimethylbenzylcarbinyl acetate   151-05-3
Benzyl isobutyrate               103-28-6
Acetyl isoeugenol                93-29-8
2-Acetyl-5-methyl furan          1193-79-9
Alpha-methyl-p-                  103-95-7
isopropylphenylpropanaldehyde
Benzylcarbinyl formate           104-62-1
p-Cresyl alpha-toluate           101-94-0
Potassium bisulfate              7646-93-7
Potassium carbonate              584-08-7
Postassium chloride              7447-40-7
Potassium hydroxide              1310-58-3
Ethyl tiglate                    5837-78-5
Nerol oxide                      1786-08-9
DL-Tetrohydrofurfuryl            637-65-0
propionate
Benzaldehyde propylene glycol    2568-25-4
acetal
2-Methyl-3-(2-furyl) acrolein    874-66-8
vanillin                         121-33-5
Cholic acid                      81-25-4
R-Carvone                        6485-40-1
Potassium nitrate                7757-79-1
Potassium permanganate           7722-64-7
Potassium persulfate             7727-21-1
Postassium phosphate, dibasic    2139900
Potassium Phosphate              7778-77-0
Monobasic
Potassium sulfate                7778-80-5
Sodium bicarbonate               144-55-8
Sodium bisulfite                 7631-90-5
Sodium carbonate                 497-19-8
Sodium chloride                  7647-14-5
Sodium dithionite                7775-14-6
Sodium hydroxide                 1310-73-2
Sodium nitrite                   7632-00-0
Sodium Pyrophosphate             7722-88-5
Sodium sulfate                   7757-82-6
Sodium sulfite                   7757-83-7
Sodium thiocyanate               540-72-7
Calcium Carbonate                471-34-1
Calcium chloride                 10043-52-4
Calcium gluconate                299-28-5
Calcium hydroxide                1305-62-0
Calcium phosphate, dibasic       7757-93-9
Calcium sulfate                  7778-18-9
N-Methyl-D-glucamine             6284-40-8
Calcium oxide                    1305-78-8
Calcium Phosphate Monobasic      7758-23-8
Magnesium chloride               7791-18-6
hexahydrate
Magnesium sulfate                7487-88-9
Magnesium Sulfate                10034-99-8
Heptahydrate
Aluminum chloride hexahydrate    7784-13-6
aluminum nitrate nonahydrate     7784-27-2
Aluminum potassium sulfate,      7784-24-9
dodecahydrate
Aluminum sulfate,                7784-31-8
octadecahydrate
(S)-(−) Cysteine                 52-90-4
p-Toluenesulfonic Acid           104-15-4
Potassium bitartrate             868-14-4
DL-aspartic acid                 617-45-8
p-Dimethylaminobenzaldehyde      100-10-7
Sodium salicylate                54-21-7
Benzoin                          119-53-9
Sodium dodecyl sulfate           151-21-3
L-Menthol                        2216-51-5
Tiron                            149-45-1
Riboflavin                       83-88-5
Sodium Acetate Trihydrate        6131-90-4
Disodium Succinate               6106-21-4
Hexahydrate
Disodium                         6381-92-6
ethylenediaminetetraacetate
dihydrate
sodium citrate, dihydrate        1545801
Sodium potassium tartrate,       6381-59-5
tetrahydrate
L-(+)-Arginine                   1119-34-2
monohydrochloride
Ethylenediamine                  333-18-6
dihydrochloride
Sodium formate                   141-53-7
Sodium acetate                   127-09-3
Potassium acetate                127-08-2
Ammonium citrate                 3012-65-5
Ammonium bicarbonate             1066-33-7
Ammonium chloride                12125-02-9
Ammonium nitrate                 6484-52-2
Ammonium persulfate              7727-54-0
Ammonium sulfate                 7783-20-2
Zinc chloride                    7646-85-7
Sulfuric acid, zinc salt         7446-20-0
(1:1), heptahydrate
Sodium Tripolyphosphate          7758-29-4
ammonium benzoate                1863-63-4
ammonium bisulfite               10192-30-0
1,5-Naphthalenedisulfonic Acid   1655-29-4
Disodium Salt
4-Hydroxybenzoic Acid            99-96-7
Diphenylacetic Acid              117-34-0
Glutaric Acid                    110-94-1
L-(−)-Flucose                    2438-80-4
L-Cysteine Hydrochloride         52-89-1
L-Histidine Hydrochloride        1880304
Monohydrate
o-Toluic Acid                    118-90-1
Pivalic Acid                     75-98-9
Pyruvic Acid Sodium Salt         113-24-6
Potassium bromide                2139626
Sodium Dithionate Dihydrate      7631-94-9
Sodium Malonate                  141-95-7
Trisodium Citrate                68-04-2
Potassium Sodium Tartrate        304-59-6
Potassium Citrate                866-84-2
D-Maltose Monohydrate            6363-53-7
Cyclohexaamylose                 10016-20-3
Dodecyl sulfate, lithium salt    2044-56-6
Manganese chloride               2145076
methyl-urea                      598-50-5
beta-Cyclodextrin                7585-39-9
Triphosphoric acid,              13845-36-8
pentapotassium salt
Glycine ethyl ester              623-33-6
hydrochloride
L-Histidine methyl ester         7389-87-9
dihydrochloride
L-Leucine methyl ester           7517-19-3
hydrochloride
D-Lysine hydrochloride           7274-88-6
2-Naphthalenesulfonic acid       532-02-5
sodium salt
calcium nitrate tetrahydrate     13477-34-4
Vitamin B1                       59-43-8
Zinc Acetate Dihydrate           5970-45-6
Potassium fluoride               7789-23-3
Potassium iodate                 2139718
Potassium iodide                 7681-11-0
Potassium thiocyanate            333-20-0
Sodium bromide                   7647-15-6
Sodium fluoride                  7681-49-4
Sodium iodide                    7681-82-5
Sodium nitrate                   7631-99-4
Calcium acetate                  5743-26-0
Trichloroacetic acid             76-03-9
Ammonium fluoride                631-61-8
DL-malic acid                    12125-01-8
t-Butyl Alcohol                  617-48-1
beta-Alanine                     75-65-0
(S)-(−) Tryptophan               107-95-9
Malonic acid                     141-82-2
Phenethylamine                   64-04-0
Salicylylaldehyde                90-02-8
Sodium benzoate                  532-32-1
Mandelic acid                    90-64-2
Calcium panthothanate            137-08-6
Chloroacetic Acid                79-11-8
Ethanol Amine                    141-43-5
Salicyclic acid                  69-72-7
Saccharin sodium                 128-44-9
Thiamine hydrochloride           67-03-8
2,2′-oxybisethanol               111-46-6
Resorcinol                       108-46-3
2-Amino-2-(hydroxymethyl)-1,3-   77-86-1
propanediol
2,5-Dimethylphenol               95-87-4
Ammonium Phosphate               7722-76-1
Monobasic
1,3-Butanediol                   107-88-0
Glycolic Acid                    79-14-1
Sodium Gluconate                 527-07-1
Terephthalic Acid                100-21-0
L-Ascorbic Acid Sodium Salt      134-03-2
3-Acetyl-6-methyl-2,4-           520-45-6
pyrandione
Calcium Acetate                  62-54-4
Nicotinamide                     98-92-0
1-Hydroxy-2-naphthoic Acid       86-48-6
2-Isopropylphenol                88-69-7
4-Aminosalicyclic Acid           65-49-6
Calcium Glycerophosphate         27214-00-2
Erythorbic Acid Sodium Salt      7378-23-6
Gluconic Acid Potassium Salt     299-27-4
Orotic Acid                      65-86-1
p-Anise Alcohol                  105-13-5
Potassium Benzoate               582-25-2
Taurine                          107-35-7
Thiamine Nitrate                 532-43-4
3,3,5-Timethyl-1-cyclohexanol    116-02-9
tert-Butylhydroquinone           1948-33-0
Sulfosalicyclic acid             97-05-2
Gallic acid                      149-91-7
L-borneol                        464-45-9
Isoborneol                       124-76-5
2,5-Dihdroxybenzoic acid,        490-79-9
Gentisic acid
5-hydroxy-6-methyl-3,4-          65-23-6
pyridinedimethanol
Naphthalene-2-sulfonic acid      120-18-3
Ethanesulfonic acid, 2-hydroxy-, 1562-00-1
monosodium salt
Pamoic acid                      130-85-8
2,4-Dimethylphenol               105-67-9
3,5-Dihydroxyacetophenone        51863-60-6
Eugenol                          97-53-0
n-Butyric Acid                   107-92-6
Hydroquinone                     123-31-9
Propionic Acid                   79-09-4
meta-Phenylenediamine            108-45-2
Oxalic Acid                      144-62-7
n-Hexanoic Acid                  142-62-1
2-Furancarboxylic Acid           88-14-2
4′-Nitroacetanilide              104-04-1
D-(−)-Tartaric Acid              147-71-7
p-Acetamidobenzoic Acid          556-08-1
Galactaric acid                  526-99-8
D-glucuronate                    1700908
Lactobionic acid                 96-82-2
p-Formylacetanilide              122-85-0
2-Mercaptobenzoic acid           147-93-3
Propanoic acid, 2-hydrox-,       28305-25-1
calcium salt (2:1), (S)-
D(+)-10-Camphorsulfonic acid     3144-16-9
3-Cyclopentylpropionic acid      140-77-2
1R-(−)Camphorsulfonic acid       35963-20-3
DL-Lysine                        70-54-2
Cinnamic acid                    621-82-9
Triethanolamine                  102-71-6
Acetic Acid                      64-19-7
Dichioroacetic Acid              79-43-6
Diethylamine                     109-89-7
Diethylaminoethanol              100-37-8
N-(2-Hydroxyethyl)Morpholine     622-40-2
Octanoic Acid                    124-07-2
isobutyric acid                  79-31-2
Anisic Acid                      100-09-4
Betaine                          107-43-7
Enantoic Acid                    111-14-8
Hippuric Acid                    495-69-2
Tiglic Acid                      80-59-1
Cyclohexanecarboxylic acid       98-89-5
m-Methoxybenzoic acid            586-38-9
D-(+)-Camphoric acid             124-83-4
N-(2-Hydroxyethyl)pyrrolidine    2955-88-6

Ionic guests are salts themselves, and may be formed from bases and acids prior to being used to form cocrystals. For example, the following bases and acids may be reacted to form ionic guests:

Bases

• • Ammonia
  • L-Arginine
  • Benethamine
  • Benzathine
  • Betaine
  • Calcium Hydroxide
  • Choline
  • Deanol
  • Diethanolamine
  • Dietbylamine
  • 2-(Diethylamino)ethanol
  • 2-Aminoethanol
  • Ethylenediamine
  • N-Methylglucamine
  • Hydrabamine
  • 1H-Imidazole
  • Lysine
  • Magnesium Hydroxide
  • Morpholine
  • 4-(2-Hydroxyethyl)Morpholine
  • piperazine
  • Potassium Hydroxide
  • Pyrrolidine
  • 1-(2-Hydroxyethyl)Pyrrolidine
  • Sodium Hydroxide
  • Triethanolamine
  • Tromethamine
  • Zinc Hydroxide Acids
  • (+)-L-Tartaric Acid
  • 1,2,2-Trimethyl-1,3-cyclopentanedicarboxylic Acid
  • 10-Undecylenic Acid
  • 1-Hydroxy-2-naphthoic Acid
  • (+)-Camphor-I0-sulfonic Acid
  • 2,5-Dihydroxybenzoic Acid
  • 2-Furancarboxylic Acid
  • 2-Mercaptobenzoic Acid
  • 3-Cyclopentylpropionic Acid
  • 3-Phenylpropionic Acid
  • 4-Aminosalicylic Acid
  • 4-Hydroxybenzoic Acid
  • Acetic Acid
  • Adipic Acid
  • alpha-Hydroxypropionic Acid
  • Benzenesulfonic Acid
  • Benzoic Acid
  • Carbonic Acid
  • Cholic Acid
  • Citric Acid
  • (−)-D-Tartaric Acid
  • (+)-D-Camphoric Acid
  • (+)-D-Malic Acid
  • (+)-L-Malic Acid
  • 2,2-Dichloroacetic Acid
  • DL-10-Camphorsulfonic Acid
  • DL-Glutamic Acid
  • DL-Malic Acid
  • DL-Tartaric Acid
  • Dodecylsulfuric Acid
  • Ethanesulfonic Acid
  • Ethylenediaminetetraacetic Acid
  • Ethylsulfuric Acid
  • Fumaric Acid
  • Galactaric Acid
  • Gallic Acid
  • Gluconic Acid
  • Glutaric Acid
  • Glycolic Acid
  • Hippuric Acid
  • Hydriodic Acid
  • Hydrobromic Acid
  • Hydrochloric Acid
  • (−)-L-Apple Acid
  • (÷)-L-Lactic Acid
  • (+)-L-′Tartaric Acid
  • D,L-Lactic Acid
  • Lactobionic Acid
  • L-Aspartic Acid
  • Lauric Acid
  • L-Glutamic Acid
  • Maleic Acid
  • (−)-L-Malic Acid
  • Malonic Acid
  • D,L-Mandelic Acid
  • Methanesulfonic Acid
  • Naphthalene-2-sulfonic acid
  • n-Butyric Acid
  • n-Decanoic Acid
  • n-Hexanoic Acid
  • Nitric acid
  • n-Tetradecanoic Acid
  • Octanoic Acid
  • Oleic Acid
  • Orotic Acid
  • Orthoboric Acid
  • Oxalic Acid
  • 4-Acetamidobenzoic Acid
  • Palmitic Acid
  • Pamoic Acid
  • Phosphoric Acid
  • Picric Acid
  • Pivalic Acid
  • Propionic Acid
  • p-Toluenesulfonic Acid
  • Pyrophosphoric Acid
  • Salicylic Acid
  • Stearic Acid
  • Succinic Acid
  • Sulfosalicylic Acid
  • Sulfuric Acid
  • Terephthalic Acid
  • Thiocyanic Acid
  • Valeric Acid
  • Valproic Acid

Typically, suitable guests will have complementary ability to noncovalently bond to the active agent or its salt, for example the ability to form hydrogen bonds with the active agent or its salt. Suitable guests for active agents having negative counterions include, but are not limited to, compounds having alcohol, ketone, ester, and/or carboxylic acid functionalities. Suitable guests may include organic acids, organic bases, organic salts, alcohols, aldehydes, amino acids, sugars, ionic inorganic compounds, aliphatic esters and ketones, and aromatic esters and ketones.

In one embodiment of the disclosure, guests are neutral and not liquids at room temperature. Also among the presently preferred neutral guests are carboxylic acids having at least three carbon atoms, alternatively at least four carbon atoms, and which do not form solvates. For example, if the following acids were combined with active agents, the combination would more properly be considered a solvate than a cocrystal: acetic acid, propionic acid, and butyric acid. However, in certain embodiments of the present invention (for example, in certain cocrystals, cocrystallization methods, and screening methods), the use of solvents and solvates may still be desirable, and the use of solvents and solvates is not excluded from the scope of any cocrystal or method except where explicitly stated.

Examples of further emobodiments of the disclosure described herein are indicated below without, however, being limiting in nature.

EXAMPLE 1

Five cocrystals of 2-4-(4-chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide (Compound 1) were identified by using techniques of the disclosure. Compound 1 possesses extremely low solubility characteristics (<0.1 μg/mL) in aqueous systems. Although the permeability of Compound 1 could not be measured in Caco-2 cells because of its inherently low solubility, Compound 1 is suspected to be a Class II compound (low solubility and high permeability) as described in the biopharmaceutical drug classification scheme (BCS) (Amidon, Gordon L., Lennernaes, Hans, Shah, Vinod P. and Crison, John R. (1995) “A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability” Pharmaceutical Research 1990, 12(3), 4 13-20). The calculated octanol/water partition coefficient (clogP) for Compound 1 is 2.9, supporting this suspicion (Yazdanian, Mehran, Glynn, Susan L., Wright, James L., and Hawi, Amale. (1998) “Correlating partitioning and Caco-2 cell permeability of structurally diverse small molecular weight compounds” Pharmaceutical Research 1998 15(9), 1490-1494). As expected with Class II BCS compounds, Compound 1 showed low in-vitro dissolution and low in-vivo plasma concentrations after oral dosing of the crystalline solid in dogs. Cocrystallization techniques were used as a tool to improve the pharmaceutical properties of Compound 1.

Physico-Chemical Characterization of Parent Compound 1 and Cocrystal 2:

Differential scanning calorimetry (DSC) was performed with a PerkinElmer, Pyris 1 DSC. Each DSC sample was sealed in a 50 μL aluminum pan with a pierced lid and heated through the respective melting temperatures at scan rates of 10° C./min. Modulated DSC was performed with a TA Instruments 2920 DSC. The amorphous glass of Compound 1 was prepared by heating at 10° C./min to 220° C. and then quickly cooling to −50° C. The glass was then heated using a modulation amplitude of ±0.80° C. and a 60 second period with an underlying heating rate of 1° C./mm. from 25 through 100° C. X-ray powder diffraction (XRPD) patterns were collected on a Philips Analytical X'Pert Plus MPD x-ray diffractometer using a Cu tube at 50 kV and 4 OmA. The scan range was 4-40 °20 with a step size of 0.02 °20/sec and the time per step of 1 second. A Surface Measurement Systems DVS-1000 was used for dynamic water sorption characterization. The sample was dried under nitrogen at 0% RH, 25° C. until the sample met equilibration conditions of less than 0.0001% weight change. The sample was cycled twice in 5% RH steps from 0 through 95% RH.

Cocrystal Screening:

Thermal microscopy methods were used to determine if a particular carboxylic acid was able to cocrystallize with Compound 1 using melt or highly saturated solution conditions. A total of 26 carboxylic acids were screened using a binary-melt technique (Kofler) on a microscope slide with mixture occurring by use of a coverslip (at the interface where the compounds mix, a molecular complex containing both components may form under appropriate conditions.) High boiling organic liquids such as methyl salicylate or methyl benzoate were used to create highly concentrated solutions in which the melting point of Compound 1 was reduced. By varying the liquid composition and concentration of each component before they were mixed, the conditions of an individual experiment could be tailored to match the particular guest being tested. A positive interaction was determined visually by observing the slide through crossed polars. In a negative interaction, the mixing of the guest and Compound 1 created a eutectic where no crystallization occurred while a positive interaction produced crystalline material at the binary interface. The products were analyzed by Raman spectroscopy. Five cocrystals were identified using this technique. A cocrystal of Compound 1 with glutaric acid was selected for further development. This cocrystal is referred to as Cocrystal 2. Thermal microscopic images were acquired using transmitted light and crossed polars on a microscope stage with temperature control.

FIG. 2 shows a solution of Compound 1 dissolved in a small amount of methyl benzoate on a glass microscope slide. A solution of glutaric acid in methyl benzoate was also generated on the same slide approximately 1 cm away from the solution of Compound 1. A coverslip was applied to both solutions simultaneously, causing the two solutions to meet at an interface where they mixed by diffusion. The solutions were allowed to cool and solids were observed growing in the solution. In image (a) the solution of glutaric acid, the guest, is located in the bottom half of images. It has solidified as two domains (one bright and one darker) with a feather-like morphology. In that image, the solution of the API appears to grow solids in the top right corner of image. The interface where the two solutions have mixed is where cocrystal formation has occurred (the cocrystal is located on the edge of the guest solid domains and is bordered by the dark liquid phase). Liquid phases are dark in the images because the slide photograph was taken through crossed polarizing filters. Crystal growth on the slide was manipulated by adjusting the temperature. In images (a), (b), and (c) the cocrystal (curved line in center) shows an increasing amount of growth at the boundary of the glutaric acid domain as the crystal growth progresses from (a) to (b) to (c). The growth of the cocrystal and the API are inhibited in the eutectic area that immediately separates them as shown in image (c).

The formation of the eutectic is temperature sensitive. At temperatures near the melting point of the solids, the eutectic forms in areas where the presence of the mixture of components acts to lower the melting point of the solids. The melting point is higher in areas where the solid is in equilibrium with a solution containing a higher percentage of the components (or a high percentage of the correct ratio of components) that make up the solid. A eutectic also has formed between glutaric acid and the cocrystal. In image (d) a narrow eutectic has formed as the temperature approaches the melting point of glutaric acid. In image (e) the glutaric acid has completely melted, clearly showing the boundary of the cocrystal solid phase. When the temperature was lowered again as shown in image (I), the glutaric acid grew in and formed a eutectic with the cocrystal phase.

Synthesis of Glutaric Acid Cocrystal 2 by Solution Methods:

Compound 1 (2.898 g, 8.431 mmol) and glutaric acid (1.111 g, 8.410 mmol) were dissolved in 150 mL of boiling chloroform with stirring. The solution was concentrated by continued boiling until the volume was 50 mL. Seeds of the cocrystal generated in thermal experiments or from previous batches were introduced to the hot solution (spontaneous nucleation under these conditions always resulted in the stable form of Compound 1). Crystallization occurred rapidly and was allowed to proceed as the solution cooled over approximately 15 minutes. Approximately 100 mL of cyclohexane were added and the resulting solution was cooled on ice for 30 minutes. Cocrystal 2 was isolated by filtration and allowed to dry in the air (3.705 g, 92% yield). A single crystal was isolated from the recovered product and used in the single crystal x-ray diffraction study.

Raman Spectroscope:

Raman spectra were collected with a Chrome Sentinel dispersive Raman unit equipped with a 785 nm, 70 mW excitation laser and a TE cooled CCD (1024×256 pixels, <0.Ie−/pixel/sec). A fiber-optically coupled filtering probe was used to collect data in the spectral range 125 cm⁻¹ to 2200 cm⁻¹ at a resolution of 4 cm⁻¹. Each spectrum is a result of two co-added 20 second scans. The unit has continuous automatic calibration using an internal standard. The data were collected by SentinelSoft data acquisition software and processed in GRAMS/Al V.7.

Single Crystal X-Ray Diffraction (SCXRD):

A suitable crystal of Compound 2 was coated with Paratone N oil, suspended in a small fiber loop and placed in a cooled nitrogen gas stream at 100 K on a Bruker D8 SMART 1000 CCD sealed tube diffractometer with graphite monochromated CuK_α (1.54178 Å) radiation. Data were measured using a series of combinations of phi and omega scans with 10 second frame exposures and 0.3° frame widths. Data collection, indexing and initial cell refinements were all carried out using SMART software (SMART Version 5.55, 2000, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). Frame integration and final cell refinements were done using SAINT software (SAINT Version 6.02, 1999, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). The final cell parameters were determined from least-squares refinement on 3625 reflections. The structure was solved using Direct methods and difference Fourier techniques (SHELXTL, VS. 10) (SHELXTL VS. 10,1997, Bruker AXS, Inc., Analytical X-ray Systems, 5465 East Cheryl Parkway, Madison Wis. 53711-5373). All the hydrogen atoms were located from difference Fouriers and included in the final cycles of least squares with isotropic U_ij's. All non-hydrogen atoms were refined anisotropically. Scattering factors and anomalous dispersion corrections are taken from the International Tables for X-ray Crystallography (A. J. C. Wilson (ed), “International Tables for X-ray Crystallography, Volume C” Kynoch, Academic Publishers, Dordrecht, 1992, Tables 6.1.1.4 (pp. 500-502) and 4.2.6.8 (pp. 219-222).). Structure solution, refinement, graphics and generation of publication materials were performed by using SHELXTL, V5.10 software.

Chemical and Physical Stability of Cocrystal 2:

Samples of cocrystal 2 were placed in glass bottles at 40° C./75% RH and 60° C. and tested periodically during two months storage. Samples were tested by XRPD, DSC, and assayed for impurities using a high performance liquid chromatography technique with ultraviolet detection (HPLC-UV) method. Cocrystal 2 was also shown to be chemically and physically stable for storage under stress conditions of 40° C./75% relative humidity (RH) and 60° C. for two months.

Intrinsic Dissolution Studies:

Intrinsic dissolution measurements were performed using a fiber optic probe (Delphian® type 11A fiber optic workstation, baseline correction mode with sample wavelength maximum of 279 nm and baseline wavelength of 350 nm) at 37° C. and 100 rpm in a USP apparatus II dissolution vessel (Vankel VK7010) containing 500 mL of pure water. Disks 0.8 cm diameter were compressed using 70 mg of solid in stainless steel dies (Vankel Woods apparatus) at 1000 lbs for 60 seconds with a Carver Press. Dissolution studies for cocrystal 2 lasted 90 minutes, after which time the disks were recovered, carefully ground and checked by XRPD for the presence of cocrystal. Due to the low solubility of Compound 1, dissolution studies were run over 24 hours in order to get a measurable rate.

Pharmacokinetic Evaluation:

A study was conducted to compare the pharmacokinetic profiles of Compound 1 and Cocrystal 2. Compound 1 and Cocrystal 2 were administered as neat solids to six male beagle dogs in a crossover study with a two-week washout period between treatments. Each dog was dosed with either Compound 1 or Cocrystal 2 in a gelatin capsule after an overnight fast. All research involving animal subjects adhered to the “Principles of Laboratory Animal Care” (NIH publication #85-23). Dose levels of 5 mg/kg and 50 mg/kg were each evaluated. Each dog received one size #2 capsule for the 5 mg/kg dose. Dosing at 50 mg/kg required use of two size #00 capsules for each dog. Blood samples were collected at intervals for 36 hours post-dose. Non-compartmental pharmacokinetic metrics were determined using WinNonlin v. 1.5 (Scientific Consulting, Inc., Mountain View, Calif.). The area under the plasma concentration-time curve (AUC) was estimated by application of the linear trapezoidal rule. Statistical analyses were conducted using Microsoft Excel 2000; statistical significance was considered when p<0.05. The glutaric acid cocrystal 2 showed an eighteen times greater intrinsic dissolution rate and three times the plasma area-under-the-curve (AUC) as compared to Compound 1 in single dose dog exposure study.

Particle Size Evaluation:

Particle size of each of the lots of Compound 1 and Cocrystal 2 dosed in the pharmacokinetic studies were characterized using an instrumented light scattering particle sizer (Malvern 2000). Samples from each lot were suspended in Millipore deionized water with S drops of Triton X-100 in 2 liters included as a dispersant. Samples were analyzed in the particle-in-liquid mode.

EXAMPLE 2

A cocrystal screen was performed on theophylline (“api”) with a series of guest compounds. Theophylline was dissolved in ethylene glycol at ˜1:3 wt/wt api:solvent. This produced a melting point depression effect that effectively lowered the melting point of theophylline from 272° C. to about 135° C. to 140° C. Theophylline crystallized rapidly from the hot ethylene glycol solution on a slide under a coverslip. The guests were most often used neat (no ethylene glycol), but ethylene glycol was used if the melting point of the guest was higher than about 140° C. or if decomposition or sublimation occurred upon melting the pure guest. This technique was confirmed as being functional by testing for a known cocrystal of theophylline and p-nitro phenol.

One to three slides were prepared for each guest compound. A spatula of guest compound was placed on the slide and melted with a heat gun or the hotstage. Two large drops of a preheated solution of theophylline in ethylene glycol were placed 1 cm from the guest and both drops were covered with a large coverslip. The boundary where the solutions merged was examined under a stereo microscope using transmitted light and crossed polars. The eutectic was cycled by heating and cooling in order to help detect and promote cocrystal formation. Salicylic acid, p-hydroxybenzoic acid, sorbic acid, 1-hydroxy-2-naphthoic acid, glycolic acid, and 2,5-dihydroxybenzoic acid were all tested as guest compounds and in each, a cocrystal formation had occurred. Raman spectra of the pure guest acid, theophylline, and the cocrystal were obtained and compared to confirm cocrystal formation.

Claims

1. A method for screening a cocrystal of an active agent and a guest comprising the steps of: a. Contacting the active agent with a suitable liquid to form an active-agent solution; b. Contacting the active-agent solution with a guest solution to form a mixture of solutions in an interface region; c. Solidifying the solution mixture in the interface region to form a solid; d. Analyzing the solid for the presence of a cocrystal.

2. The method of claim 1 wherein the analysis is performed by observing the formation of eutectic regions on both sides of the cocrystal in the interface region.

3. The method of claim 1 wherein the solidification occurs by lowering the temperature of the interface region mixture.

4. The method of claim 1 wherein the guest solution is a melt of the guest.

5. The method of claim 1 wherein the guest solution is prepared by contacting the guest with a suitable liquid.

6. The method of claim 5 wherein the suitable liquid contacted with the active agent is the same as that which is contacted with the guest.

7. The method of claims 1, 5, or 6 wherein the suitable liquid has a higher boiling point than the melting point of the active agent.

8. The method of claims 5 or 6 wherein the suitable liquid has a higher boiling point that the melting point of the guest.

9. The method of claim 1 wherein the analytical technique is selected from optical microscopy, x-ray powder diffraction, single-crystal x-ray analysis, Raman spectroscopy, Raman microscopy, and infrared spectroscopy.

10. A method for preparing a cocrystal of an active agent and a guest comprising the steps of: a. Contacting the active agent with a suitable liquid to form an active-agent solution; b. Contacting the active-agent solution with a guest solution to form a mixture of solutions in an interface region; c. Solidifying the solution mixture in the interface region to form a cocrystal.