Claims
- 1. A method for therapeutic or prophylactic treatment of breast tumor burden in a warm-blooded mammalian host comprising administering to said host a pharmacologically effective amount of a combination of IL-2 from a mammalian species and at least one immunotoxin that binds selectively to cells containing the tumor burden.
- 2. The method of claim 1 wherein the combinations of IL-2 and immunotoxin is administered separately to the host.
- 3. The method of claim 2 wherein the IL-2 is administered in an amount of 3-3.75 to 7.5.times.10.sup.6 U/kg of host weight, and the immunotoxin is administered in an amount of 25 to 500 .mu.g/kg of host weight.
- 4. The method of claim 3 wherein the IL-2 is administered first, followed by a second administration of IL-2 at the same time as the first administration of the immunotoxin(s).
- 5. The method of claim 3 wherein the IL-2 is first administered at the same time as the immunotoxin(s).
- 6. The method of claim 8 wherein the IL-2 is initially administered alone as a local administration, and the later administration of the IL-2 and immunotoxin(s) is systemic.
- 7. The method of claim 1 wherein the IL-2 is human recombinant IL-2.
- 8. The method of claim 7 wherein the IL-2 is mature human IL-2, des-ala.sub.1 -IL-2.sub.ser 125, des-ala.sub.1 -IL-2.sub.ala 104ser125, IL-2.sub.ser 125, IL-2.sub.ala 104, IL-2.sub.ala 104ser125, des-ala.sub.1 IL-2, or des-ala.sub.1 IL-2.sub.ala 104.
- 9. The method of claim 1 wherein the immunotoxin comprises a recombinant ricin A chain conjugated to a monoclonal antibody that is IgG or IgM.
- 10. The method of claim 9 wherein the antibody is 520C9 or 260F9.
- 11. The method of claim 1 wherein the host is human.
- 12. The method of claim 1 wherein the combination is administered in repeated doses.
Parent Case Info
This is a division of application Ser. No. 055,681, filed May 29, 1987, which is a continuation-in-part of application Ser. No. 892,596, filed Aug. 1, 1986.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4604377 |
Fernandes et al. |
Aug 1986 |
|
Foreign Referenced Citations (5)
Number |
Date |
Country |
0153114 |
Aug 1985 |
EPX |
0189849 |
Aug 1986 |
EPX |
0220858 |
May 1987 |
EPX |
8504328 |
Oct 1985 |
WOX |
8700054 |
Jan 1987 |
WOX |
Non-Patent Literature Citations (6)
Entry |
Dr. Rosenstein et al., J. Immunol. (1986), 137:1735-1742. |
Shaw et al., Cell Immunol. (1985), 91:193-200. |
Shaw et al., Cell Immunol. (1985), 90:547-554. |
Nonomura et al., Hepatology (1984), 4:1087. |
Kimber et al., J. Clin. Lab. Immunol. (1984), 15:77-84. |
Lotze et al., J. Immunol. (1985), 135:2865. |
Divisions (1)
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Number |
Date |
Country |
Parent |
55681 |
May 1987 |
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Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
892596 |
Aug 1986 |
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