Compression sequenced thermal therapy system

Abstract
A sequential compression and temperature therapy blanket with a plurality of air chambers is disclosed. The air chambers are filled and released by a valve assembly that may be separate from or integrated within the blanket. The temperature therapy blanket includes a fluid bladder for delivering hot and/or cold therapy to a patient. The temperature therapy blanket may also include an air bladder for providing compression.
Description
BACKGROUND

1. Technical Field


The present invention relates to thermal therapy systems in general, including therapeutic cooling, heating, and compression systems used in association therewith, and more particularly, but not by way of limitation, to a programmable, sequential compression system adapted for high thermal contrast modality, and incorporating multiple, independently controllable chambers in a thermal therapy blanket.


2. Description of the Related Art


Medical care providers have long recognized the need to provide warmth and cooling directly to patients as part of their treatment and therapy. Better recoveries have been reported using cold therapy for orthopedic patients. The benefits of warming patients undergoing surgery has been conclusively proven. It is also desirable to cool portions of a patient's anatomy in certain circumstances. Yet another advantageous therapy is the application of heat then cold to certain areas of injury.


Several devices have been developed that deliver temperature controlled fluids through pads or convective thermal blankets to achieve the above purpose. Typically these devices have a heating or a cooling element, a source for the fluid, a pump for forcing the fluid through the pad or blanket, and a thermal interface between the patient and the temperature controlled fluid. U.S. Pat. No. 4,884,304 to Elkins is directed to a mattress cover device which contains liquid flow channels which provide the selective heating or cooling by conduction.


Devices have also been developed for providing heat to a person in bed. Electric blankets containing electric heating elements have been used for years to warm a person in bed.


Cooling blankets, such as the blanket disclosed in U.S. Pat. No. 4,660,388 to Greene, have also been proposed. Greene discloses a cooling cover having an inflatable pad with plenum chambers at opposite ends thereof. Cool air is generated in a separate unit and directed to the pad and out a number of apertures on the underside of the pad and against the body of the person using the cover.


A disposable heating or cooling blanket is disclosed in U.S. Pat. No. 5,125,238 to Ragan, et al which has three layers of flexible sheeting. Two of the layers form an air chamber and the third includes a comfortable layer for contact with the patient. Conditioned air is directed toward the covered person through a multiplicity of orifices in the bottom layers of the blanket.


A temperature controlled blanket and bedding assembly is disclosed in commonly assigned U.S. Pat. No. 5,989,285 to DeVilbiss et al., the disclosure of which describes a temperature controlled blanket and temperature control bedding system which has the provision of both recirculating temperature controlled fluid and temperature controlled gas to enhance performance for convectively heating or cooling a patient. Counter-flow or co-flow heat exchanging principles between the temperature controlled liquid and the temperature controlled gas achieve temperature uniformity across different sections of the blanket and the bedding system. Drapes and the temperature controlled bedding system provided temperature controlled envelope around a person using the bedding system. In one embodiment of the bedding system, the air portion of the bedding system is provided for use with a patient that supplies the fluid portion of the overall bedding system. In another embodiment of the bedding system, the fluid portion of the bedding system is provided for use with a patient bed which supplies the air portion of the overall bedding system.


U.S. Pat. No. 5,097,829 to Quisenberry describes an improved temperature controlled fluid circulating system for automatically cooling a temperature controlled fluid in a thermal blanket with a thermoelectric cooling device having a cold side and a hot side when powered by electricity. The temperature controlled fluid is cooled by the cold side of the cooling device and pumped through, to, and from the blanket through first and second conduits.


SUMMARY

The present invention relates to a sequential compression blanket for use with heating or cooling therapy. In one aspect, an embodiment of the blanket comprises a plurality of air chambers and a valve assembly. The valve assembly controls the flow of air to each air chamber in order to provide sequential, pulsing, or constant compression to the patient.


In another aspect, one embodiment of the invention includes a compression therapy blanket comprising a plurality of gas, such as air, chambers for receiving a gas to cause compressions, a valve assembly, internal to the compression therapy blanket, for delivering gas to each of the plurality of air chambers in a predetermined pattern, an inlet port for delivering air from a control unit to the valve assemblies, and a plurality of connection for delivering gas from the valve assembly to the plurality of gas/air chambers. The plurality of gas/air chambers may comprise four to seven chambers and an electrical signal connection may be provided for transmitting data related to the predetermined pattern to the valve assembly. One embodiment includes the predetermined pattern comprises sequential inflation of the plurality of chambers to produce series of compression movements peripherally toward the heart of a patient, while another embodiment includes inflating two of the plurality of gas/air chambers simultaneously.


In yet another aspect, the above described compression therapy blanket further comprises a heat transfer fluid bladder for providing temperature therapy to a portion of a patient. The bladder includes a fluid inlet port for delivering heat transfer fluid from the control unit to the heat transfer fluid bladder and a fluid outlet port for delivering heat transfer fluid from the heat transfer fluid bladder to the control unit. The heat transfer fluid bladder delivers thermal therapy to a patient in the form of heat or cold or alternating heat and cold.


In yet another aspect, one embodiment of the invention includes a temperature therapy blanket comprising, a fluid bladder for housing heat transfer fluid, the fluid bladder having a top layer and a bottom layer, a plurality of connections for dispersing the heat transfer fluid throughout the blanket, the plurality of connections connecting the top layer to the bottom layer of the fluid bladder, at least one partition for directing the flow of the heat transfer fluid through the bladder; and means for providing sequenced flows of alternating heat and cold in a high thermal contrast modality to a patient.


In another embodiment of the invention, the above-described temperature therapy blanket further comprises an air bladder disposed outwardly of the fluid bladder in an overlapping relationship therewith for providing select compression therapy, the air bladder having an upper layer and a lower layer and an inlet port for providing air from the control unit to the air bladder.


Yet a further aspect includes one embodiment of the invention comprising a system for passing heat transfer fluid between a control unit and a blanket. The system comprises a reservoir for housing heat transfer fluid for utilization by the system, a flow network in flow communication with the reservoir and including a junction having at least three branches, wherein a first branch receives heat transfer fluid from the reservoir, a second branch receives the heat transfer fluid returning from the blanket, and a third branch for delivering the heat transfer fluid to the blanket, and a pump for creating a low pressure site at the third branch, wherein the low pressure site causes the heat transfer fluid from the second branch to be pulled into the third branch. In one embodiment of the invention, the three-point junction is generally configured as an inverted Y from a fluid flow standpoint.





BRIEF DESCRIPTION OF THE DRAWINGS

A more complete understanding of the method and apparatus of the present invention may be obtained by reference to the following Detailed Description when taken in conjunction with the accompanying Drawings wherein:



FIG. 1 is an illustration of the patient therapy system according to an embodiment of the present invention;



FIG. 2 is a block diagram illustrating the flow of heat transfer fluid according to an embodiment of the present invention;



FIG. 3 is a block diagram of the control circuitry according to an embodiment of the present invention;



FIGS. 4A-4C are block diagrams of thermoelectric device assemblies according to embodiments of the present invention;



FIGS. 5A-5B are illustrations of a cross-sectional view of the blanket portion of the patient therapy system according to an embodiment of the present invention;



FIG. 5C is an illustration of a bottom view of the blanket in accordance with an embodiment of the present invention;



FIG. 5D is an illustration of a cross-sectional view of the blanket of FIG. 5C in an inverted position relative to FIG. 5C;



FIG. 6A is an illustration of the valve assembly and sequential compression blanket in accordance with one embodiment of the present invention;



FIG. 6B is an illustration of the valve assembly and sequential compression blanket in accordance with an alternate embodiment of the present invention;



FIG. 6C is an illustration of the valve assembly of FIG. 6A according to an alternate embodiment of the present invention;



FIG. 6D is an illustration of the valve assembly of FIG. 6B according to an alternate embodiment of the present invention;



FIGS. 7A-7I are illustrations of several exemplary embodiments of the patient therapy system of the present invention; and



FIG. 8 is an illustration of a method of creating and packaging a heat transfer fluid utilized according to an embodiment of the present invention.





DETAILED DESCRIPTION

Referring to FIG. 1, there is shown a patient therapy system 2 according to the principles of the present invention. The patient therapy system 2 comprises a control unit 4, a blanket 8, and a connector 10. The blanket 8 further comprises an emergency relief valve 9. In operation, a heat transfer fluid is deposited in the control unit 4 via an aperture 14. The heat transfer fluid is cooled or heated by the control unit 4 and pumped to the blanket 8 by connector tubes 6. The heat transfer fluid flows into the blanket 8 through an inlet port, and exits through an outlet port to the control unit 4 via the connector 10 and connector tubes 6. Similarly, a gas may be pumped by the control unit 4 to the blanket 8 through the connector tubes 6 and the connector 10 to provide compression therapy. In addition, additional connector tubes 6 may be present to allow for both heat transfer fluid and gas to be passed to the blanket for simultaneous temperature therapy and compression therapy.


The control unit 4 receives data and manipulates any one of a plurality of therapeutic characteristics of the blanket 8 based on the data. The blanket 8 is adapted for the administration of hot, cold, and/or compression therapies to a body portion of the patient. For example, the blanket 8 may extend from the fingertips to the shoulder, the toes to the hip, or various other configurations. Current thermal design requirements for temperature therapy in accordance with one embodiment of the present invention are as follows: 1) the system must be able to heat the fluid from around 49° F. to around 105° F. with the largest blanket attached to a typical man at an ambient of 77° F. within 10 minutes, 2) the system must be able to cool the fluid from 105° F. to 49° F. with the largest blanket attached to a typical man at an ambient of 77° F. within 20 minutes, and 3) the system must cool the fluid to 37° F. at an ambient of 77° F. within 90 minutes. These requirements should be with a minimum compression of 25 mm Hg. In addition, according to some embodiments, the blanket 8 may diffuse oxygen into the portion of the body. The connector 10 provides a fluid and/or gas connection between the control unit 4 and the blanket 8 for the transfer of gas and heat transfer fluid. The connector 10 may also allow for transfer of electrical sensor signals and/or data signals between the blanket 8 and the control unit 4. The emergency relief valve 9 is utilized to quickly decompress the blanket 8 if needed.


Referring now to FIG. 2, a block diagram of one embodiment of the flow of heat transfer fluid between the control unit 4 and the blanket 8 is illustrated. The control unit 4 includes a heat transfer fluid reservoir 200 and at least one heat transfer assembly (HTA) 202 for heating and/or cooling the heat transfer fluid. Before the blanket 8 is utilized for temperature therapy, the system is primed with the heat transfer fluid. When the system is primed, substantially no air exists in the tubes 204 between the reservoir 200, HTA 202, and blanket 8. The flow tubes in the control unit 4 between the reservoir 200, HTA 202, and blanket 8 form a three-point junction 204C. In the preferred embodiment, the three-point junction 204C is formed as an inverted Y, however, other shapes and orientations are possible. By utilizing a three-point junction 204C, the heat transfer fluid returning from the blanket 8 is recirculated to the HTA 202 without utilizing heat transfer fluid from the reservoir 200. The three-point junction 204C allows the HTA 202 to heat or cool the heat transfer fluid that has already been heated or cooled prior to entering the blanket 8. In the preferred embodiment, the HTA 202 does not heat or cool the entire contents of the reservoir 200, but merely the portion of the heat transfer fluid that is currently circulating through the blanket 8 and tubing 204. In essence, the reservoir is generally “by-passed” unless more fluid volume is needed. In the three-point junction 204C, heat transfer fluid returning from the blanket 8 may be pulled, via a pump, to the HTA 202. If more heat transfer fluid than that which is already circulating through the system is required, then the heat transfer fluid from the reservoir is introduced into the system.


Referring now to FIG. 3, and more specifically to the control unit 4, control circuitry 300 according to an embodiment of the present invention is illustrated. The control circuitry 300 is coupled to pre-cooling and pre-heating circuitry 302, thermal profile circuitry 304, patient profile circuitry 306, time duration circuitry 308, hot and cold indicator circuitry 310, and compression profile circuitry 312. The control circuitry 300 is further coupled to a memory 314, detection circuitry 316, warning circuitry 318, and a backup battery 320. A display 322 is provided for displaying the output of the control circuitry 300 and for the input of data to control various therapeutic values of the blanket 8. A dual water and gas reservoir 324 having water and gas reservoir circuitry 326 is further coupled to the control circuitry 300. Reservoir circuitry 326 is coupled both to the control circuitry 300 and to a plurality of thermal electric coolers 328. The thermal electric coolers 328 heat and/or cool the heat transfer fluid contained within the fluid/gas reservoir 324. Coupled to the thermal electric coolers 328, there is shown a phase plane heat removal system 330.


Coupled to the control circuitry 300 is the pre-cooling and pre-heating circuitry 302 which heats and/or cools the temperature of the heat transfer fluid prior to the application of the blanket 8 to the patient. Thermal profile circuitry 304, patient profile circuitry 306, and compression profile circuitry 312 allow the user of the patient therapy system 2 to apply compression and/or thermal therapy to a patient according to preset values which depend on the type of injury and physical attributes of the patient. Exemplary attributes of the patient, thermal, and/or compression profiles are illustrated in Table 1 below.













TABLE 1







Patient Record
Bytes
Type









RTC Year
1
character



RTC Month
1
character



RTC Day
1
character



RTC Hour
1
character



RTC Minute
1
character



Coolant Set Temp
2
signed integer



Coolant Temp
2
signed integer



Compression Set
1
unsigned character



Compression Reading
2
unsigned integer



Therapy Mode
1
bit



Compression Switch Status
2
bits



Control Mode
3
bits



Alarms
1
bit










As illustrated in Table 1, a record of the actual use of the temperature therapy blanket may be recorded by the Year, Month, Day, Hour, and Minute attributes. The temperature therapy settings and compression settings may also be stored via the Coolant Set Temp and Compression Set attributes. The actual temperature and compression may be stored via the Coolant Temp and Compression Reading attributes. The particular therapy mode chosen is assigned to the Therapy Mode attribute. For example, the patient may wish to apply cooling therapy without compression, heat therapy without compression, contrast therapy without compression, cooling therapy with compression, heat therapy with compression, contrast therapy with compression, or compression without temperature therapy. The profiles and usage data may also be sent to a computer or printed for medical records, etc.


The detection circuitry 316 is coupled to the control circuitry 300 and to the connector 10 of FIG. 1 to alert the user of whether the connector 10 is properly or improperly connected to the blanket 8. A disconnect signal may be sent to the control circuitry 300 to warn the user of a problem with the connector 10. The battery backup 320 supplies power to the control unit 4 during periods when an AC current is not available. The control circuitry 300 may also forward data related to specifics of the temperature and compression therapy to the display 322. The display 322 may display indicators related to the data from the control circuitry 300 and/or other portions of the system 2.


The control circuitry 300, in conjunction with the memory 314, thermal profile circuitry 304, patient profile circuitry 306, time duration circuitry 308, and compression profile circuitry 312 provides cooling and heating therapy with a programmable set point between 37 and 66° F. and 90 and 105° F. The control circuitry 300 allows for contrast therapy programmable for alternating between cooling for a predetermined time interval and heating for a predetermined time interval, or constant therapy for only heating or only cooling for a predetermined time interval. The control circuitry 300 also allows for compression therapy separate from, or in conjunction with, the contrast or constant thermal therapy. Compression therapy enhances thermal contact for more efficient thermal transfer with the tissue under therapy. The compression therapy may also provide pulse compression by alternating between a plurality of chosen pressure levels to gently, but firmly pulse massage the tissue. Compression therapy that sequentially compresses a portion of the patient under therapy may also be initiated from the control circuitry 300. Further, the control circuitry 300, in conjunction with the memory 314, may provide optional electronic recording of therapy patient identification and chosen thermal, contrast, constant, compression, and/or oxygen treatment levels applied with time indicators and duration indicators of each treatment mode as noted above with respect to Table 1. The patient may optionally readout, print, and/or electronically retain the therapy patient record within the memory 50. Moreover, the control circuitry 300 may provide a bio-impedance measurement to estimate the total body water content to assess hydration conditions. Also, an exemplary embodiment of the patient therapy system 2 of FIG. 1 may provide electronic muscle stimulation to accelerate return of muscle condition to normal.


Referring now to FIG. 4A, there is shown a diagrammatic schematic of one embodiment of an improved thermoelectric device assembly in accordance with one embodiment of the principles of the present invention. The TEC of this particular embodiment incorporates a layer of gold that interfaces with the ceramic. This particular interface affords the necessary strength to connect the ceramic directly to the billets for a high thermal contrast modality in accordance with certain aspects of the present invention. With such a design, a much higher thermal contrast modality and thermal cycle capability is achieved. Moreover, it has been suggested by Applicants herein that with such an assembly, approximately 100,000 heating and cooling cycles may be possible in the high thermal contrast modality. The present embodiment affords an arrangement of the appropriate TEC interface materials with the heat exchanger to optimize the ability to accept high thermal contrast through thousands of cycles manifesting extreme expansion and contraction as is inherent in high contrast thermal systems. The utilization of thermal grease between the TEC and the heat sink and manifold is currently contemplated. It has further been recognized that the layer of gold appears to reduce the stress on the solder joints within the TEC. A more robust connection is thus afforded between the ceramic and the other elements inside the TEC. It has further been recognized that the use of thermal grease instead of plastics and the like is preferable in at least one embodiment of the present invention.


Referring now to FIG. 4B, a diagrammatic schematic illustrates thermal cycling with the TEC capable of withstanding the stresses of thermal cycling. The TEC is capable of withstanding the stresses of thermal cycling during normal operation at the following conditions: 150 PSI loading, ΔT in the cooling mode, cool side=15° C.; hot side=60° C. With such an embodiment, the following performance matrix may be realized: Thermal characteristics: Qmax≧52 Watts at 25° C.


Referring now to FIG. 4C, physical characteristics of one embodiment of the present invention are illustrated. The leads and perimeter of the TEC must be sealed with a sealant that will meet the following: AC Hipot of 1700 VAC for 1 minute with the TEC's sandwiched between two ground planes and a leakage requirement of ≦10 mA at 1700 VAC. It is preferable for the sealants used for the leads and the perimeter to be of similar materials.


Referring now to FIG. 5A, there is shown the connector 10 of FIG. 1 connected to the therapy blanket 8. A plurality of connections 15 extend throughout the interior of the fluid bladder of blanket 8 so as to avoid all concentration of fluid in one portion of the therapy blanket 8. Layer 18 is a layer of a gas/fluid impermeable material and layer 20 is a second layer of gas/fluid impermeable material. A first bladder, defined by layers 18 and 20, contains heat transfer fluid from the water/gas reservoir 324 (via tubes 500 and 502) while the second bladder, which is defined by layers 20 and 16, receives gas (via tube 504). A single connection 15 is formed by sealing layers 18 and 20 one to another. Layers 16, 18, and 20 are sealed one to another along their periphery.


In an exemplary embodiment shown in FIG. 5B, gas permeable layer 28 is coupled beneath the gas bladder and fluid bladder of FIG. 5A. Layer 28 may be sealed contiguous with the periphery of the gas bladder and fluid bladder of FIG. 5A. A tube 26 injects oxygen into the gas permeable layer 28 for diffusion along a surface of the patient via a series of diffusion holes 30 formed in layer 28. One method of providing oxygen to an injured portion of a patient is described in the aforementioned U.S. Pat. No. 5,989,285 to DeVilbiss et al.


Referring now to FIG. 5C, a temperature therapy blanket 8 having a pre-selected shape and compression capabilities is illustrated. The underside of the blanket 8 (shown) is placed directly against a portion of the patient. The fluid bladder is thus adjacent the patient. Heat transfer fluid flows into the blanket 8 from inlet hose 500 and heat transfer fluid flows out of the blanket via outlet hose 502. A gas, for compression, flows into the blanket 8 from air inlet hose 504. The air inlet hose 504 may also be utilized to provide oxygen for oxygenation purposes. Alternatively, oxygenation gas may be provided by a separate hose. Heat transfer fluid travels through the inlet hose 500, through fluid inlet port 506, and into the blanket 8. The connections 15 allow the heat transfer fluid to evenly disperse throughout the fluid bladder. Partitions 508a, 508b control the flow of heat transfer fluid throughout the fluid bladder. Partition 508a prevents heat transfer fluid from entering the blanket 8 at the inlet port 506 and immediately exiting the blanket via outlet port 510. Partition 508a forces the heat transfer fluid to travel towards the end of the blanket 8 remote from the inlet port 506. Partition 508b, in conjunction with connections 15, causes the heat transfer fluid to travel across the width of the blanket 8. The edges of the fluid bladder are joined to the edges of the air bladder at seal 512. The heat transfer fluid may then exit the blanket 8 at the outlet port 510. The travel of the heat transfer fluid is indicated by arrows in FIGS. 5C and 5D.


Referring now to FIG. 5D, the blanket 8 is turned over relative to FIG. 5C and a cross-sectional view along line A-A of FIG. 5C is illustrated. As described above, the fluid bladder 514 (disposed against the patient) and air bladder 516 are joined together at seal 512. Connections 15 join the upper layer and lower layer of the fluid bladder 514 together. The partition 508a segregates the heat transfer fluid from the inlet port 506, illustrated by the downward arrows, from the heat transfer fluid flowing to the outlet port, illustrated by the upward arrows. The air bladder 516 is oriented over the fluid bladder 514 to press the fluid bladder 514 against a portion of the patient (not shown in this view).


Referring now to FIG. 6A, a sequential compression blanket 8 in accordance with an embodiment of the present invention is illustrated. The sequential compression blanket 8 may also include temperature therapy as illustrated above, or the sequential compression blanket 8 may be a stand alone blanket that may be applied directly to a surface of a patient or over a temperature therapy blanket. The sequential compression blanket 8 includes a plurality of air chambers 602 with inlet lines 604 for each air chamber 602. In the preferred embodiment, the blanket 8 includes four to seven air chambers 602, although more or fewer air chambers 602 may be utilized in accordance with embodiments of the present invention. Tubing 606 connects the inlet lines 604 to a valve assembly 608 that is separate from both the blanket 8 and the control unit 4. Additional tubing 610 connects the valve assembly 608 to the control unit 4. The valve assembly 608 operates to control the flow of air to each chamber 602 via valves (not shown) that allow air flow to the tubing 606 for each air chamber 602. The valve assembly 608 may operate to provide sequential compression in a first direction by first filling and releasing air chamber 602a, next filling and releasing air chamber 602b, and lastly filling and releasing air chamber 602c. The valve assembly 608 may operate to provide sequential compression in the opposite direction by first filling and releasing air chamber 604c, next filling and releasing air chamber 604b, and lastly filling and releasing air chamber 604a. Alternatively, the valve assembly 608 may provide pulsing compression by substantially simultaneously filling the air chambers 602 and, a predetermined time interval later, releasing the air chambers 602. Although the above embodiment illustrates specific sequential and pulsing compression techniques, it will be understood by one skilled in the art that numerous compression techniques may be utilized without departing from aspects of the present invention. For example, multiple air chambers 602 may be filled simultaneously or compression could be applied by first filling air chamber 602a, next filling air chamber 602b, lastly filling air chamber 602c, and releasing the air chambers 602 substantially simultaneously. In various embodiments, the air chambers 602 are sequenced to provide movement peripherally toward the heart.


The valve assembly 608 receives sequencing instructions from an electrical line 612 that connects to the control unit 4. The electrical line 612 may also provide for communication of other data, such as sensor data or oxygenation data, between the blanket 8 and the control unit 4. For example, the blanket 8 may include temperature sensors to determine the temperature of the heat transfer fluid within the blanket 8. The sensor data is then transmitted to the control unit 4, via the electrical line 612, so that the control unit 4 may adjust the cooling or heating of the heat transfer fluid as necessary.


Referring now to FIG. 6B, an alternate embodiment of the present invention is illustrated. This embodiment includes a valve assembly 608 that is internal to the sequential compression blanket 8 and four air chambers 602 within the sequential compression blanket 8, although the amount of air chambers may vary from blanket to blanket. The valve assembly 608 functions in a manner similar to the valve assembly 608 of FIG. 6A except that an additional valve is provided for the fourth air chamber 602d and tubing 606d. The valve assembly 608 and tubing 606 are internal to the sequential compression blanket 8. Therefore, the only item visible to a patient is the tubing 610 that exits the sequential compression blanket 8 and connects to the control unit 4. Although the sequential compression blanket 8 has been illustrated as a substantially rectangular blanket, it will be understood by one skilled in the art that the blanket 8 may be formed in any shape to conform to any portion of a patient's body, such as a shoulder, wrist, foot, neck, back, etc.


Referring now to FIGS. 6C-6D, alternate embodiments of the sequential compression blanket 8 is illustrated. The blanket as shown also includes a fluid bladder with an inlet fluid tube 614 and outlet fluid tube 616. The compression functions similarly to that described in FIGS. 6A and 6B except that the compression bladder presses the fluid bladder onto a portion of the patient. The fluid bladder may be similar to that illustrated in FIGS. 5A-5D, although other configurations of fluid bladders may be utilized in conjunction with the compression blanket of embodiments of the present invention.


Referring now to FIGS. 7A-7I, various configurations of the blanket 8 adaptable to various portions of a patient body are illustrated. Although the blankets 8 are illustrated with a specific configuration of tubing, connectors, fasteners, etc., it will be understood by one skilled in the art that other configurations may be utilized in accordance with embodiments of the present invention.


Referring now to FIG. 8, a method of creating and packaging a heat transfer fluid according to an embodiment of the present invention is illustrated. Although the heat transfer fluid described below may be utilized with the present invention, other heat transfer fluids may also be utilized in conjunction with the system of the present invention. In the preferred embodiment, the heat transfer fluid incorporates water with propylene glycol. A 15% solution of propylene glycol with distilled water is suggested to reduce the freezing set point within the heat transfer fluid and to eliminate the accumulation of bacteria. At step 800, distilled water is provided. At step 802, monopropylene glycol is provided and is mixed with the water at step 804. The distilled water and monopropylene glycol may be mixed in a ratio of about 15% monopropylene glycol and 85% distilled water. The mixture is packaged at step 806 and installed at step 808.


The previous description is of a preferred embodiment for implementing the invention, and the scope of the invention should not necessarily be limited by this description. The scope of the present invention is instead defined by the following claims.

Claims
  • 1. A system for providing therapy to a patient, the system comprising: a thermal therapy and compression blanket comprising: at least one fluid bladder disposed about and thermally exposed to a portion of an appendage of a patient; anda plurality of air chambers disposed outwardly of the at least one fluid bladder relative to the appendage of the patient;a control unit that thermally conditions a heat-transfer fluid to a predetermined temperature for delivery to the at least one fluid bladder and that selectively provides compressed gas at predetermined times and in a predetermined pattern to the plurality of air chambers to cause compression of the at least one fluid bladder against the patient; andwherein compressed gas is directed by the control unit to a first air chamber of the plurality of air chambers for a first predetermined time before the compressed gas is directed by the control unit to a second air chamber of the plurality of air chambers for a second predetermined time.
  • 2. The system of claim 1, wherein the control unit comprises a heat-transfer assembly having thermoelectric coolers for actively thermally conditioning the heat-transfer fluid.
  • 3. The system of claim 1, wherein the control unit conducts the thermally conditioned heat-transfer fluid through the at least one fluid bladder and, contiguous thereto, provide compressed gas in the predetermined pattern.
  • 4. The system of claim 1, wherein the control unit is programmable and selectively provides compressed gas to each of the plurality of air chambers in a user-programmable pattern.
  • 5. The system of claim 1, wherein the control unit provides compressed gas to a third air chamber of the plurality of air chambers for a third predetermined time after providing compressed gas the second air chamber.
  • 6. The system of claim 5, wherein the control unit re-provides compressed gas to the first air chamber after providing compressed gas to the third air chamber.
  • 7. The system of claim 1, wherein the control unit releases the compressed gas from the first air chamber before providing compressed gas to the second air chamber.
  • 8. The system of claim 1, wherein the control unit releases the compressed gas from the first air chamber after providing compressed gas to the second air chamber.
  • 9. The system of claim 1, wherein the control unit comprises: a reservoir for housing at least a portion of the heat-transfer fluid;a three-point junction having three branches;a first branch of the three branches for receiving the heat-transfer fluid from the reservoir;a second branch of the three branches for receiving the heat-transfer fluid from the at least one fluid bladder; anda third branch of the three branches for delivering the heat-transfer fluid to the at least one fluid bladder.
  • 10. The system of claim 9, wherein the heat-transfer fluid is circulated through the second branch, the third branch, and the at least one fluid bladder via a closed-loop fluid circuit.
  • 11. The system of claim 10, wherein heat-transfer fluid may be added or removed from the closed-loop fluid circuit via the first branch.
  • 12. A system for providing therapy to a patient, the system comprising: a blanket comprising:at least one fluid bladder disposed about and thermally exposed to a patient; anda plurality of air chambers disposed outwardly from the at least one fluid bladder relative to the patient;a control unit coupled to the at least one fluid bladder and the plurality of air chambers, the control unit thermally conditioning a heat-transfer fluid to a user-selectable temperature for delivery to the at least one bladder and, contiguous thereto, selectively providing compressed gas at a predetermined pressure to each of the plurality of air chambers in a user-selectable pattern;the plurality of air chambers having at least a first air chamber and a second air chamber;wherein the control unit directs compressed gas to the first air chamber for a first predetermined time before directing compressed gas to the second air chamber; andwherein the control unit directs compressed gas to the second air chamber for a second predetermined time before directing compressed gas to the third air chamber.
  • 13. The system of claim 12, wherein the control unit directs compressed gas to the first air chamber after directing compressed gas to a third air chamber of the plurality of air chambers for a third predetermined time.
  • 14. The system of claim 12, wherein the control unit releases the compressed gas from the first air chamber after the first predetermined time.
  • 15. The system of claim 12, wherein the control unit releases the compressed gas from the first air chamber after providing compressed gas to the second air chamber.
  • 16. The system of claim 12, wherein the control unit is programmable and contiguously flows the heat-transfer fluid through the fluid bladder at a user-programmable temperature while at the same time directs compressed gas to one or more of the plurality of air chambers in a user-programmable pattern.
  • 17. The system of claim 12 and further comprising: a heat-transfer assembly having thermoelectric coolers for actively thermally conditioning the heat-transfer fluid.
  • 18. The system of claim 12, wherein the control unit comprises: a reservoir for housing at least a portion of the heat-transfer fluid;a three-point junction having three branches;a first branch of the three branches that receives the heat-transfer fluid from the reservoir;a second branch of the three branches that receives the heat-transfer fluid from the at least one fluid bladder; anda third branch of the three branches that delivers the heat-transfer fluid to the at least one fluid bladder.
CROSS-REFERENCE TO RELATED APPLICATIONS

The present application is a divisional application of U.S. patent application Ser. No. 10/894,369, filed Jul. 19, 2004 entitled, “COMPRESSION SEQUENCED THERMAL THERAPY SYSTEM,” which claims the benefit of, and incorporates by reference for any purpose the entire disclosure of, U.S. Provisional Patent Application Ser. Nos. 60/488,709 filed Jul. 18, 2003; 60/550,658 filed Mar. 5, 2004; and 60/588,453, filed Jul. 16, 2004. This application is also related to, and hereby incorporates by reference, commonly assigned U.S. Pat. Nos. 5,097,829, 5,989,285, and U.S. patent application Ser. No. 09/328,183 filed Jun. 8, 1998.

US Referenced Citations (350)
Number Name Date Kind
773828 Titus et al. Nov 1904 A
2110022 Kliesrath Mar 1938 A
2504308 Donkle, Jr. Apr 1950 A
3014117 Madding Dec 1961 A
3164152 Vere Nicoll Jan 1965 A
3345641 Jennings Oct 1967 A
3367319 Carter, Jr. Feb 1968 A
3548809 Conti Francesco Dec 1970 A
3608091 Olson et al. Sep 1971 A
3660849 Jonnes et al. May 1972 A
3736764 Chambers et al. Jun 1973 A
3738702 Jacobs Jun 1973 A
3744053 Parker et al. Jul 1973 A
3744555 Fletcher et al. Jul 1973 A
3862629 Rotta Jan 1975 A
3894213 Agarwala Jul 1975 A
4006604 Seff Feb 1977 A
4013069 Hasty Mar 1977 A
4029087 Dye et al. Jun 1977 A
4206751 Schneider Jun 1980 A
4224941 Stivala Sep 1980 A
4375217 Arkans Mar 1983 A
4402312 Villari et al. Sep 1983 A
4459468 Bailey Jul 1984 A
4459822 Pasternack Jul 1984 A
4471787 Bentall Sep 1984 A
4503484 Moxon Mar 1985 A
4547906 Nishida et al. Oct 1985 A
4597384 Whitney Jul 1986 A
4608041 Nielsen Aug 1986 A
D285821 Kneisley Sep 1986 S
D288372 Adams Feb 1987 S
4660388 Greene, Jr. Apr 1987 A
D295897 Thimm-Kelly May 1988 S
4741338 Miyamae May 1988 A
4821354 Little Apr 1989 A
4844072 French et al. Jul 1989 A
4884304 Elkins Dec 1989 A
4901200 Mazura Feb 1990 A
4911231 Horne et al. Mar 1990 A
4926881 Ichinomiya et al. May 1990 A
4962761 Golden Oct 1990 A
4969881 Viesturs Nov 1990 A
4979375 Nathans et al. Dec 1990 A
4989589 Pekanmaki et al. Feb 1991 A
4995698 Myers Feb 1991 A
4996970 Legare Mar 1991 A
5044364 Crowther Sep 1991 A
5051562 Bailey et al. Sep 1991 A
D320872 McCrane Oct 1991 S
5067040 Fallik Nov 1991 A
5080089 Mason et al. Jan 1992 A
5090409 Genis Feb 1992 A
5092271 Kleinsasser Mar 1992 A
5097829 Quisenberry Mar 1992 A
5106373 Augustine et al. Apr 1992 A
5112045 Mason et al. May 1992 A
5117812 McWhorter Jun 1992 A
5125238 Ragan et al. Jun 1992 A
5165127 Nicholson Nov 1992 A
5179941 Siemssen et al. Jan 1993 A
5184612 Augustine Feb 1993 A
5186698 Mason et al. Feb 1993 A
5230335 Johnson, Jr. et al. Jul 1993 A
5232020 Mason et al. Aug 1993 A
5241951 Mason et al. Sep 1993 A
5243706 Frim et al. Sep 1993 A
5263538 Amidieu et al. Nov 1993 A
5285347 Fox et al. Feb 1994 A
D345082 Wenzl Mar 1994 S
D345609 Mason et al. Mar 1994 S
D345802 Mason et al. Apr 1994 S
D345803 Mason et al. Apr 1994 S
5300101 Augustine et al. Apr 1994 A
5300102 Augustine et al. Apr 1994 A
5300103 Stempel et al. Apr 1994 A
5303716 Mason et al. Apr 1994 A
5316250 Mason et al. May 1994 A
D348106 Mason et al. Jun 1994 S
5323847 Koizumi et al. Jun 1994 A
5324319 Mason et al. Jun 1994 A
5324320 Augustine et al. Jun 1994 A
D348518 Mason et al. Jul 1994 S
5330519 Mason et al. Jul 1994 A
5336250 Augustine Aug 1994 A
5343579 Dickerhoff et al. Sep 1994 A
5350417 Augustine Sep 1994 A
D351472 Mason et al. Oct 1994 S
5352174 Mason et al. Oct 1994 A
5354117 Danielson et al. Oct 1994 A
D352781 Mason et al. Nov 1994 S
5360439 Dickerhoff et al. Nov 1994 A
5370178 Agonafer et al. Dec 1994 A
5371665 Quisenberry et al. Dec 1994 A
D354138 Kelly Jan 1995 S
D357747 Kelly Apr 1995 S
5402542 Viard Apr 1995 A
5405370 Irani Apr 1995 A
5405371 Augustine et al. Apr 1995 A
5407421 Goldsmith Apr 1995 A
D358216 Dye May 1995 S
5411494 Rodriguez May 1995 A
5411541 Bell et al. May 1995 A
5417720 Mason May 1995 A
5440450 Lau et al. Aug 1995 A
5449379 Hadtke Sep 1995 A
5466250 Johnson, Jr. et al. Nov 1995 A
5496262 Johnson, Jr. et al. Mar 1996 A
5505726 Meserol Apr 1996 A
5507792 Mason Apr 1996 A
5509894 Mason et al. Apr 1996 A
5528485 Devilbiss et al. Jun 1996 A
5561981 Quisenberry et al. Oct 1996 A
5566062 Quisenberry et al. Oct 1996 A
D376013 Sandman et al. Nov 1996 S
5578022 Scherson et al. Nov 1996 A
5588954 Ribando et al. Dec 1996 A
5591200 Cone et al. Jan 1997 A
D380874 Caswell Jul 1997 S
5648716 Devilbiss et al. Jul 1997 A
D383546 Amis et al. Sep 1997 S
D383547 Mason et al. Sep 1997 S
D383848 Mason et al. Sep 1997 S
5662695 Mason et al. Sep 1997 A
5672152 Mason et al. Sep 1997 A
5675473 McDunn et al. Oct 1997 A
5682748 DeVilbiss et al. Nov 1997 A
5689957 DeVilbiss et al. Nov 1997 A
5690849 DeVilbiss et al. Nov 1997 A
5711029 Visco et al. Jan 1998 A
5711155 DeVilbiss et al. Jan 1998 A
D393073 Downing et al. Mar 1998 S
5731954 Cheon Mar 1998 A
5733321 Brink Mar 1998 A
D394707 Tsubooka May 1998 S
5755755 Panyard May 1998 A
5772618 Mason et al. Jun 1998 A
5782780 Mason et al. Jul 1998 A
5795312 Dye Aug 1998 A
5807294 Cawley et al. Sep 1998 A
5827208 Mason Oct 1998 A
5831824 McDunn et al. Nov 1998 A
D403779 Davis et al. Jan 1999 S
D404490 Tripolsky Jan 1999 S
D405884 Roper Feb 1999 S
5871526 Gibbs et al. Feb 1999 A
5890371 Rajasubramanian et al. Apr 1999 A
5901037 Hamilton et al. May 1999 A
5923533 Olson Jul 1999 A
5947914 Augustine Sep 1999 A
5980561 Kolen et al. Nov 1999 A
5989285 DeVilbiss et al. Nov 1999 A
6007559 Arkans Dec 1999 A
6055157 Bartilson Apr 2000 A
6058010 Schmidt et al. May 2000 A
6058712 Rajasubramanian et al. May 2000 A
6080120 Sandman et al. Jun 2000 A
D428153 Davis Jul 2000 S
D430288 Mason et al. Aug 2000 S
D430289 Mason et al. Aug 2000 S
6117164 Gildersleeve et al. Sep 2000 A
6125036 Kang et al. Sep 2000 A
6129688 Arkans Oct 2000 A
6135116 Vogel et al. Oct 2000 A
6176869 Mason et al. Jan 2001 B1
6186977 Andrews et al. Feb 2001 B1
6238427 Matta May 2001 B1
6260890 Mason Jul 2001 B1
6270481 Mason et al. Aug 2001 B1
6295819 Mathiprakasam et al. Oct 2001 B1
6305180 Miller et al. Oct 2001 B1
6319114 Nair et al. Nov 2001 B1
6352550 Gildersleeve et al. Mar 2002 B1
6358219 Arkans Mar 2002 B1
6368592 Colton et al. Apr 2002 B1
6436064 Kloecker Aug 2002 B1
6443978 Zharov Sep 2002 B1
6462949 Parish, IV et al. Oct 2002 B1
6468237 Lina Oct 2002 B1
6508831 Kushnir Jan 2003 B1
D472322 Hoglund et al. Mar 2003 S
D473315 Miros et al. Apr 2003 S
D473656 Miros et al. Apr 2003 S
D473948 Elkins et al. Apr 2003 S
6551264 Cawley et al. Apr 2003 B1
D474544 Hoglund et al. May 2003 S
6562060 Momtaheni May 2003 B1
6596016 Vreman et al. Jul 2003 B1
6648904 Altshuler et al. Nov 2003 B2
D484601 Griffiths et al. Dec 2003 S
D484602 Griffiths et al. Dec 2003 S
6660027 Gruszecki et al. Dec 2003 B2
6667883 Solis et al. Dec 2003 B1
6675072 Kerem Jan 2004 B1
D486870 Mason Feb 2004 S
6695823 Lina et al. Feb 2004 B1
6719713 Mason Apr 2004 B2
6719728 Mason et al. Apr 2004 B2
6736787 McEwen et al. May 2004 B1
D492411 Bierman Jun 2004 S
6775137 Chu et al. Aug 2004 B2
D496108 Machin et al. Sep 2004 S
6789024 Kochan, Jr. et al. Sep 2004 B1
6802823 Mason Oct 2004 B2
D499846 Cesko Dec 2004 S
6834712 Parish et al. Dec 2004 B2
6846295 Ben-Nun Jan 2005 B1
6848498 Seki et al. Feb 2005 B2
6855158 Stolpmann Feb 2005 B2
6893414 Goble et al. May 2005 B2
D506553 Tesluk Jun 2005 S
6935409 Parish, IV et al. Aug 2005 B1
6936019 Mason Aug 2005 B2
D510140 Brown Sep 2005 S
6945988 Jones Sep 2005 B1
D510626 Krahner et al. Oct 2005 S
D515218 McGuire et al. Feb 2006 S
D523147 Tesluk Jun 2006 S
7066949 Gammons et al. Jun 2006 B2
7081128 Hart et al. Jul 2006 B2
D533668 Brown Dec 2006 S
D551351 Silva Sep 2007 S
D551352 Frangi Sep 2007 S
7306568 Diana Dec 2007 B2
7354411 Perry et al. Apr 2008 B2
D568482 Gramza et al. May 2008 S
D569985 Ganapathy et al. May 2008 S
7427153 Jacobs et al. Sep 2008 B1
7429252 Sarangapani Sep 2008 B2
7484552 Pfahnl Feb 2009 B2
7492252 Maruyama Feb 2009 B2
D595620 Kingsbury Jul 2009 S
D601707 Chouiller Oct 2009 S
D608006 Avitable et al. Jan 2010 S
D612947 Turtzo et al. Mar 2010 S
D613870 Shust Apr 2010 S
7717869 Eischen, Sr. May 2010 B2
D618358 Avitable et al. Jun 2010 S
D619267 Beckwith et al. Jul 2010 S
D620122 Cotton Jul 2010 S
D625018 Smith et al. Oct 2010 S
D626241 Sagnip et al. Oct 2010 S
D626242 Sagnip et al. Oct 2010 S
D626243 Sagnip et al. Oct 2010 S
D626245 Sagnip et al. Oct 2010 S
D627896 Matsuo et al. Nov 2010 S
D628300 Caden Nov 2010 S
D630759 Matsuo et al. Jan 2011 S
7871387 Tordella et al. Jan 2011 B2
D631971 Turtzo et al. Feb 2011 S
D633657 Oban Mar 2011 S
D634437 Gramza et al. Mar 2011 S
D634851 Chiang Mar 2011 S
D635266 Chiang Mar 2011 S
D635267 Chiang Mar 2011 S
7896910 Schirrmacher et al. Mar 2011 B2
D636497 Giaccone Apr 2011 S
D638950 Janzon May 2011 S
D640380 Tweardy et al. Jun 2011 S
D640381 Tweardy et al. Jun 2011 S
D649648 Cavalieri et al. Nov 2011 S
8052630 Kloecker et al. Nov 2011 B2
D655420 Bowles Mar 2012 S
D655821 Matsuo Mar 2012 S
D657063 Chiang Apr 2012 S
D660438 Kennedy et al. May 2012 S
D660439 Chen et al. May 2012 S
D663850 Joseph Jul 2012 S
D665088 Joseph Aug 2012 S
D665470 Galbraith Aug 2012 S
D666258 Campbell Aug 2012 S
D666301 Joseph Aug 2012 S
8449483 Eddy May 2013 B2
20010039439 Elkins et al. Nov 2001 A1
20020116041 Daoud Aug 2002 A1
20020143373 Courtnage et al. Oct 2002 A1
20030050594 Zamierowski Mar 2003 A1
20030083610 McGrath et al. May 2003 A1
20030089486 Parish et al. May 2003 A1
20030089487 Parish, IV et al. May 2003 A1
20030127215 Parish, IV et al. Jul 2003 A1
20030135252 MacHold et al. Jul 2003 A1
20030163183 Carson Aug 2003 A1
20030176822 Morgenlander Sep 2003 A1
20040008483 Cheon Jan 2004 A1
20040030281 Goble et al. Feb 2004 A1
20040046108 Spector Mar 2004 A1
20040054307 Mason et al. Mar 2004 A1
20040068309 Edelman Apr 2004 A1
20040068310 Edelman Apr 2004 A1
20040099407 Parish, IV et al. May 2004 A1
20040133135 Diana Jul 2004 A1
20040186535 Knowlton Sep 2004 A1
20040193218 Butler Sep 2004 A1
20040210176 Diana Oct 2004 A1
20040221604 Ota et al. Nov 2004 A1
20040260231 Goble et al. Dec 2004 A1
20050004636 Noda et al. Jan 2005 A1
20050006061 Quisenberry et al. Jan 2005 A1
20050033390 McConnell Feb 2005 A1
20050039887 Parish, IV et al. Feb 2005 A1
20050070828 Hampson et al. Mar 2005 A1
20050070835 Joshi Mar 2005 A1
20050133214 Pfahnl Jun 2005 A1
20050143797 Parish et al. Jun 2005 A1
20050177093 Barry et al. Aug 2005 A1
20050182364 Burchman Aug 2005 A1
20050256556 Schirrmacher et al. Nov 2005 A1
20050274120 Quisenberry et al. Dec 2005 A1
20050284615 Parish et al. Dec 2005 A1
20060034053 Parish et al. Feb 2006 A1
20060058714 Rhoades Mar 2006 A1
20060116620 Oyaski Jun 2006 A1
20060241549 Sunnen Oct 2006 A1
20060276845 George et al. Dec 2006 A1
20060282028 Howard et al. Dec 2006 A1
20070032778 Heaton et al. Feb 2007 A1
20070068651 Gammons et al. Mar 2007 A1
20070112401 Balachandran et al. May 2007 A1
20070118194 Mason et al. May 2007 A1
20070129658 Hampson et al. Jun 2007 A1
20070233209 Whitehurst Oct 2007 A1
20070260162 Meyer et al. Nov 2007 A1
20070282249 Quisenberry et al. Dec 2007 A1
20080058911 Parish et al. Mar 2008 A1
20080064992 Stewart et al. Mar 2008 A1
20080071330 Quisenberry et al. Mar 2008 A1
20080082029 Diana Apr 2008 A1
20080103422 Perry et al. May 2008 A1
20080132976 Kane et al. Jun 2008 A1
20080249559 Brown et al. Oct 2008 A1
20080319362 Joseph Dec 2008 A1
20090069731 Parish et al. Mar 2009 A1
20090109622 Parish et al. Apr 2009 A1
20090149821 Scherson et al. Jun 2009 A1
20090254160 Shawver et al. Oct 2009 A1
20100010477 Augustine et al. Jan 2010 A1
20100030306 Edelman et al. Feb 2010 A1
20100081975 Avitable et al. Apr 2010 A1
20100121230 Vogel et al. May 2010 A1
20100137764 Eddy Jun 2010 A1
20100145421 Tomlinson et al. Jun 2010 A1
20100150991 Bernstein Jun 2010 A1
20100249679 Perry et al. Sep 2010 A1
20100249680 Davis Sep 2010 A1
20110009785 Meyer et al. Jan 2011 A1
20110034861 Schaefer Feb 2011 A1
20110071447 Liu et al. Mar 2011 A1
20110082401 Iker et al. Apr 2011 A1
20110087142 Ravikumar et al. Apr 2011 A1
Foreign Referenced Citations (8)
Number Date Country
670 541 Jun 1989 CH
35 22 127 Jan 1987 DE
0 489 326 Jun 1992 EP
2373444 Sep 2002 GB
689674 Oct 1979 SU
WO-9309727 May 1993 WO
WO-0040186 Jul 2000 WO
WO-0114012 Mar 2001 WO
Non-Patent Literature Citations (25)
Entry
Artikis, T., PCT International Preliminary Report on Patentability as mailed Jul. 29, 2005, (10 pgs.).
Tom Lee, T.Y. et al; “Compact Liquid Cooling System for Small, Moveable Electronic Equipment”, IEEE Transactions on Components, Hybrids, and Manufacturing Technology, Oct. 15, 1992, No. 5, pp. 786-793.
Cyro/Temp Therapy Systems; Product News Catalogue; Jobst Institute, Inc., 6 pages.
Copenheaver, Blaine R., International Search Report for PCT/US2007/022148 as mailed Apr. 2, 2008, 2 pages.
Young, Lee W., “International Search Report” for PCT/US07/08807 as mailed Mar. 3, 2008, (2 pages).
U.S. Appl. No. 12/708,422, Balachandran et al.
Quisenberry, Tony, “U.S. Appl. No. 29/424,860”, filed Jun. 15, 2012.
Quisenberry, Tony, “U.S. Appl. No. 13/456,410”, filed on Apr. 26, 2012.
U.S. Appl. No. 13/190,564, Quisenberry et al.
Copenheaver, Blaine R., “International Search Report” for PCT/US2012/035096 as mailed Aug. 7, 2012, 3 pages.
Quisenberry, Tony, “U.S. Appl. No. 13/558,615”, filed Jul. 26, 2012.
U.S. Appl. No. 29/400,194, Quisenberry.
U.S. Appl. No. 29/400,202, Quisenberry.
U.S. Appl. No. 29/400,212, Quisenberry.
U.S. Appl. No. 29/402,115, Quisenberry.
U.S. Appl. No. 12/871,188, Parish et al.
Quisenberry, Tony, “U.S. Appl. No. 13/359,210”, filed Jan. 26, 2012.
Mahmoud Karimi Azar Daryany, et al., “Photoinactivation of Escherichia coli and Saccharomyces cerevisiae Suspended in Phosphate-Buffered Saline-A Using 266- and 355-nm Pulsed Ultraviolet Light”, Curr Microbiol, vol. 56, 2008, pp. 423-428.
J. Li, et al., “Enhanced germicidal effects of pulsed UV-LED irradiation on biofilms”, Journal of Applied Microbiology, 2010, pp. 1-8.
U.S. Appl. No. 13/107,264, Quisenberry.
U.S. Appl. No. 12/364,434, Quisenberry.
U.S. Appl. No. 14/062,428, Quisenberry.
U.S. Appl. No. 13/796,139, Quisenberry.
Copenheaver, Blaine R., “International Search Report” prepared for PCT/US2013/030475 as mailed May 23, 2013, 3 pages.
U.S. Appl. No. 13/962,994, Quisenberry.
Related Publications (1)
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20110077723 A1 Mar 2011 US
Provisional Applications (3)
Number Date Country
60488709 Jul 2003 US
60550658 Mar 2004 US
60588453 Jul 2004 US
Divisions (1)
Number Date Country
Parent 10894369 Jul 2004 US
Child 12730060 US