Patent Application
20190083161
The present invention relates generally to plasma generation. In particular, the present invention relates to modified and improved plasma torches, an electrical power generator unit and methods of operation thereof for producing a plasma plume having a controlled thermal plasma. The plasma plume finds particular utility in a wide range of treatments such as the cosmetic treatment of skin, in surgical and non-surgical treatment of wounds and in sterilization of objects in industrial processes.
Surface ablation of biological tissue is a process used in a variety of medical procedures. An ablation process may be used to remove unwanted tissue and can also be used, in certain tissues, to stimulate or induce regeneration and renewal.
Various cosmetic treatments are known and widely used that attempt to reduce the effects of ageing through surface ablation or other minor trauma of the skin to induce regeneration thereof. The skin is made up of two main layers, the dermis and the epidermis which provides the exposed surface. The epidermis comprises layers of maturing skin cells one on top of the other, with the outermost layer being a layer of dead cells that is shed and replaced by layers underneath as they reproduce. These cosmetic procedures aim to improve the appearance of patient's skin with the intention of, for example, reducing visible fine lines and wrinkles, ‘rejuvenating’ the skin to remove pigment spots and providing a smoother finish, and improving the appearance of scar tissue, such as scars resulting from acne.
These cosmetic procedures typically fall into three categories: mechanical procedures, chemical procedures and laser procedures.
‘Mechanical’ procedures achieve the resurfacing of the skin by removing unwanted skin by mechanical abrasion. Microdermabrasion is a light, non-invasive nonsurgical cosmetic procedure that works to achieve the removal of dead skin cells in the topmost layer of the epidermis by action small abrasive granular crystals of, for example, aluminium oxide. Microdermabrasion is useful for cosmetically treating fine irregularities in the texture of the skin, fine wrinkles and superficial scarring, but it is temporary in its effect and it is typically not capable of improving the appearance of the skin by deep resurfacing and rejuvenation to remove more significant wrinkles and scarring.
Dermabrasion, on the other hand, is a more significant, surgical procedure for effectively removing the top to mid-layers of the skin (the epidermis and even the dermis) using abrasive wheels, brushes and sandpaper to mechanically attack and remove unwanted skin. As deep layers of skin tissue are removed, significant bleeding can often result and so a local or even general anaesthetic is required and dermabrasion is typically performed by a medical professional in a medical or surgical setting. The deep ablation and resurfacing of skin by dermabrasion can, following recovery, achieve an improved skin appearance by removing deeper scarring, fine wrinkles and skin irregularities. However, with dermabrasion there is no fine depth control, and the abrasives have to be applied to a wide area of the skin in order to ‘blend’ the finish, preventing effective treatment of localized irregularities. The traumatic effect on the skin and required recovery time of dermabrasion is significant.
Chemical peel procedures use a variety of chemical types which when applied directly to the skin, change the skin composition and cause unwanted skin to slough off the surface. Lighter peels can be applied in non-medical settings in cosmetic skincare treatment centres and these can achieve moderate, longer term improvement in the appearance of fine wrinkles and minor skin irregularities. However, medium and higher strength peels that remove skin to deeper layers are surgical treatments that require the expertise of medical practitioners to understand the effect of the chemical peel mixture, but can achieve improved skin appearance of more significant wrinkles and irregularities. However, there is no fine depth control available in any chemical peels, and the peel treatment must be applied to the whole area of the skin-13 e.g. the face, preventing localized treatment. Chemical peels can often require long recovery periods and also side effects on the skin such as photosensitivity. Repeat peels may also be needed to achieve a desired effect for a longer term.
Laser skin resurfacing, however, has addressed a number of shortcomings of dermabrasion and chemical peels and is capable of achieving skin resurfacing and rejuvenation to significantly improve skin appearance, and can even reduce the appearance of deeper wrinkles including frown lines and crow's feet. Here, a CO2 or Er:YAG laser light is used to act to rejuvenate the skin by dissociating the molecular bonds in the surface and subsurface layers of the skin to induce trauma and cause the skin (in particular the layers of the epidermis) to rejuvenate. In addition, the deep heating of the lower layers of the skin by the laser is understood to stimulate fibroblasts in the dermis to form new collagen and elastin to increase the turgor (elasticity) and thickness of the skin, helping to reduce the appearance of deep wrinkles and aging skin. Rather than laser treating the entire surface of the skin, laser treatments typically are delivered to a fraction of the skin in a pattern of pinpoints (or Microscopic Treatment Zones, MTZ) spread over an area of the skin, between which healthy skin remains, which reduces healing time and recovery. Compared to dermabrasion and chemical peels, laser treatment does allow a degree of localized control based on the requirements of the skin area by area. However, this pinpoint patterning of the ablated skin can leave a visible patterned finish even after recovery that is emphasized should further treatment (such as a facelift) be undertaken. As a result of this finish, laser skin resurfacing is not suitable for using in treating small ‘zones’ of skin, as the pattern of pin pricks cannot be blended.
A metric useful for assessing energy sources for ablation is fluence, defined for pulsed laser ablation energy sources as the energy of the laser pulse (Joules, J) divided by the area of the incident laser spot (in cm2). Generally, the greater the fluence of the laser, the greater the depth of penetration and rejuvenation of the dermis. For a typical comparison, energy levels achieved using one, well-known system marketed under the trade name Fraxel™ re:pair™ available from Fraxel range from 5-70 mJ/MTZ, giving a high level of equivalent fluence in the order of a hundred Joules per cm2. Thus a high, concentrated energy transfer is achievable with pulsed fractionated laser systems to a low level of the dermis. For the Fraxel™ re:pair™ system, the penetration depth achievable is from 200-1500 microns. As such, laser treatment is capable of achieving improved deep wrinkle reduction and skin resurfacing with significantly reduced bleeding, side effects and recovery time compared to dermabrasion and strong chemical peels. As a result, laser skin resurfacing can be provided as a cosmetic non-surgical treatment in a non-medicalised setting, administered by a trained operator who is not necessarily a medical professional.
It has been suggested that plasma, the fourth state of matter, formed by, for example, ionizing a gas, could be used to rejuvenate skin. One such system using a gas plasma for ablative tissue rejuvenation was developed by Rhytec Ltd in the United Kingdom and is now marketed under the brand name of NeoGen™ by Energist Ltd. of United Kingdom, for which more information is currently available from the following URL: http://www.energistgroup.com/.
Rhytec Ltd's International patent application publication no. WO 2001/62169A2 discloses the technology underlying the development of the NeoGen™ system. The Rhytec Ltd published patent application discloses a handheld surgical instrument having a conduit carrying nitrogen gas and an electrode structure and radio frequency pulsed power source arranged to produce a dielectric barrier discharge inside the conduit that weakly ionizes the nitrogen gas to produce a low energy, non-thermal plasma to be emitted at a nozzle of the conduit. The plasma produced at the nozzle is used in the cosmetic treatment of fine wrinkles and skin irregularities and operates to rapidly transfer heat to the dermis to stimulate collagen production and increase skin elasticity and thickness. However, unlike with laser treatments, this dermal heating and rejuvenation does not occur at the same time as direct ablation (e.g. by vaporisation) of the upper layers of the epidermis. Thus the side effects and down time of this treatment are less significant than for laser treatment. However, the energy levels transferrable by the NeoGen™ system are only 2-6 Joules per pulse across the size of the plasma plume, are relatively low and unconcentrated compared to laser skin resurfacing, being spread over a spot size of over a square centimetre, giving a low equivalent fluence value on the order of 1 J/cm2. While, unlike for laser light, absorption of the plasma energy is not dependent on the presence of a particular cholorophore (e.g. water present in cells for CO2 lasers) leading to more uniform absorption across cell types, skin types and structures, the low equivalent fluence of the NeoGen™ plasma system means that its ability to reliably and effectively treat deep wrinkles and achieve significant skin resurfacing is questionable. The lack of any direct skin ablation, combined with the low fluence, means that the usefulness of the NeoGen™ system for skin resurfacing and removal of significant skin irregularities and wrinkles is very limited. Indeed a large number of repeat procedures may be needed to achieve any noticeable benefit for anything more significant than fine wrinkles and minor skin imperfections.
Non-ablative treatments to improve the appearance of ageing skin include the use of dermal fillers, botox and collagen which are injected into the skin. However, these are invasive interventions that have significant side effects on the appearance of the individual by bulking out skin and paralyzing muscles. These treatments do not themselves fundamentally rejuvenate the skin, but rather they seek to achieve improved appearance by ‘sculpting’ the skin and ‘filling out’ wrinkles, which can appear unnatural.
Another non-ablative treatment is radio frequency, infrared or ultrasound skin tightening therapy in which radio frequency, infrared light or ultrasound waves are used to heat the skin to attempt to promote collagen formation to tighten the skin.
However, the effect of these treatments is not significant and is only short term in benefit, requiring a large number of repeat sessions.
In view of the above, there is an ongoing desire to further improve dermal treatment and rejuvenation mechanisms, and it is in this context that the present invention is devised.
There is disclosed a plasma torch having an open end from which a plume of plasma or plasma effluent, for use in therapeutic treatment of tissue in vivo, preferably skin and/or wounds, is emitted in use, comprising: a cathode rod; a grounded conductive tube having at least one opening and being arranged around the cathode and spaced therefrom to form a cavity in which, in use, an arc discharge between the cathode and grounded conductor ionizes a feed gas to produce a thermal plasma, the plasma or effluent being emitted in a plume from the opening of the grounded conductor; wherein the opening of the grounded conductor tube comprises a lip, the inwardly facing surface of which defining an orifice, the orifice having a length to an opening width ratio of at least 2.5:1. The orifice may have a length to an opening width ratio of at least 3:1, optionally at least 4:1, optionally at least 5:1.
The present inventors have realised that the provision of a thermal plasma of sufficiently low energy to not cause irreparable, non-therapeutic damage to skin, but sufficiently high to cause a controlled absorption of plasma energy in tissue, can have a significantly beneficial therapeutic effect. For example, in cosmetic applications, thermal plasmas of appropriate fluence can be used to ablate surface skin tissue layers and heat subsurface dermal layers. This can be used to treat deep wrinkle removal, surface wrinkle removal, achieve skin resurfacing and address other skin conditions. The more uniform absorption of plasma energy by skin tissue, and energy distribution across a plasma plume, as well as the relatively energies delivered, makes thermal plasma desirable as an energy source for skin treatment.
A key consideration for the practicality and effectiveness of the application of thermal plasmas to cosmetic treatment of skin however is the reliability of the ignition of the plasma, the uniformity of the energy delivery over time, and the stability of the plasma energy delivery. Further, a thermal plasma, particularly when delivered alone, without a cooling non-thermal plasma surrounding it, may cause a relatively high energy delivery to the patient, which may cause some discomform to the patient, and may require more expertise, such as that of a cosmetic surgeon rather than a trained nurse, to apply the treatment. By providing a plasma torch that produces a thermal plasma only from a single plasma cavity, a relatively slimline torch can be produced, which facilitates ergonomic handling and application.
The present inventors have found that the provision of a plasma torch with a grounded conductor tube having a lip defining an orifice having a length to an opening width (e.g. a diameter) ratio of at least 2.5:1 (i.e. at least 5 mm long by 2 mm in diameter) or higher, the plasma or plasma effluent has sufficient thermal energy wicked away by the grounded conductor tube acting as a heat sink in close contact with the plasma as it passes through the relatively large surface area of the orifice, so as to control and reduce the fluence of the emitted plume and reduce the thermal energy delivery to the patient. At these sufficiently high aspect ratios, the orifice acts as a tunnel or channel by which the temperature (and direction) of the outgoing gas can be controlled. This enables the modification of the thermal flux delivery to the treatment area and permits a wider range of aesthetic treatment options. For example, a grounded cathode tube having an aspect ratio of 4.5:1 (i.e. 8 mm long by 2 mm in diameter) has been found to deliver a thermal plasma sufficiently cooled to the level that facilitates easy treatment as the impact on the tissue is not as significant, and also reduces any discomfort a patient may experience. Further, it has been observed that the lengthening and tightening of the orifice channel to having higher aspect ratios results in a more stable and uniform output of thermal energy in the plasma plume, apparently due to gas mixing effects as the plasma is produced and mixed further back inside the grounded conductive tube. This facilitates the provision of a torch for cosmetic applications to that generates thermal plasma only, which greatly facilitates ergonomic handling of he torch for fine treatment.
Further, this recessing of the cathode from the proximity of the opening at the end of the orifice, by the lengthing of the orifice channel to having aspect ratios of length to width of 2.5:1 or higher, has significantly beneficial effects on the stability and controllability of the plasma as well as the useful lifetime of the electrodes. This lengthening and tightening of the orifice to higher aspect ratios reduces the influence of atmospheric gases on the recessed electrode configuration, because the atmospheric gases are less likely to enter into the plasma-generating cavity during use. This results in a reduction of electrode oxidation, extending the useful life of the electrodes and increasing the reliability of the produced plasma for a longer period of time. A reduction of influence of external environment on plasma properties, such as humidity, further increases the reliability of the ignition of the plasma, and the stability of the plasma once ignited. In this arrangement, the plasma is produced more inside the cavity produced by the grounded conductive tube and emanates out of the plasma torch through the orifice as plasma (or plasma effluent) in a directed plume. This also reduces the likelihood of the plasma production falling out of place by the arc hotspot moving forwards through the opening towards the outside of the cavity. This prolapsing of the plasma creation and mixing of the arc with air rather than feed gas can have significantly damaging effects on the electrodes and the species produced in the plasma, and the treated tissue. The greater the aspect ratio of the orifice, and the more recessed the cathode, the greater these effects. The limit of how far recessed the electrode geometry can be is set only by the length of the cathode, which could even be reduced to zero in the case that a flat (non-sharpened) cathode is used.
In embodiments, the orifice may have a length of at least 6 mm, optionally at least 7 mm, optionally at least 8 mm, optionally at least 9 mm, optionally at least 10 mm. In embodiments, the orifice may have an opening width of at most 4 mm, optionally at most 3 mm, optionally at most 2 mm. The dimensions of the orifice length and opening width are selected from these embodiments to provide the orifice having a length to an opening width ratio of at least 2.5:1. The orifice may have a length to an opening width ratio of at least 3:1, optionally at least 4:1, optionally at least 5:1.
In embodiments, the cathode may be recessed from the opening at the surface in the conductive tube, such that the thermal plasma is, in use, produced inside the grounded conductor tube and passes through an orifice having a length to an opening width ratio of at least 2.5:1, and at least 8 mm in length. In this arrangement, a stable, uniform thermal plasma is produced having a lower energy suitable for easy application.
In embodiments, the orifice may be configured to wick thermal energy away from the thermal plasma or plasma effluent before it is emitted from the opening in the grounded conductive chamber. In embodiments, the cross section of the orifice varies along its length to change the surface area of the wicking region. The surface area of the orifice in close contact with the plasma may be configured to increase energy wicking or stability of the plasma plume.
In embodiments, the cathode may have a rounded or flattened or non-pointed end, and/or is not tapered towards its end. By increasing the length and reducing the width of the orifice, the plasma can be produced inside the cavity and emanated to the patient through the orifice. In this way, the arc hotspot on the cathode can be allowed to wander and does not need to be fixed to stably produce a plasma at or near the cavity exit near the patient. As a result, the cathode can be non-tapered or non-pointed, being rounded or flattened at the end, which further increases the usable life of the electrodes in the reliable production of plasma.
In embodiments, the plasma torch may configured to, in normal use, only be usable to produce the thermal plasma. In embodiments, the plasma torch does not comprise components configured to produce, in normal use, a non-thermal plasma or dielectric barrier discharge plasma. The invention enables a usable and stable thermal plasma only plasma torch to be provided, which facilitates the ergomic design and reduces the size and thickness of the torch.
In embodiments, the plasma torch may further comprise a plasma active cooling mechanism configured to, in normal use, to cause or be operable to cause a temperature of the plasma or plasma effluent emitted as a plume from the plasma torch to be cooled. An active cooling mechanism may be used to further reduce the heat of the thermal plasma produced at the opening, beyond the thermal energy wicking already achieved by the lengthened and narrowed orifice. The active cooling can further enable control of the delivered energy, improve patient outcomes and reduce discomfort.
In embodiments, the plasma active cooling mechanism comprises one or of: means for pre-cooling the feed gas; means for mixing the plasma or plasma effluent with a cooler gas.
In embodiments, the cathode rod may further comprise a thermionically emissive material, which in use enhances the ionization of the feed gas between the cathode and grounded conductive tube. In embodiments, the cathode rod may further comprises a material resilient to operation using non-inert feed gases. Such a material may be Lanthanum Hexaboride.
In emboduments, the opening in the grounded conductor tube is configured to direct the plasma or plasma effluent emitted therefrom in a direction away from directly towards the treatment direction in normal use. By producing the plasma inside the grounded conduction tube and emitting it through a lengthened and narrowed orifice tunnel, the plasma plume can be directed in a required direction which may be in a direction away from a direction directly towards the treatment direction in normal use.
In embodiments, the plasma torch is configured to be operated with an arc current of 2A-5A between the central cathode rod and grounded conductive tube, the arc current preferably being fixed during plasma production. In embodiments, the plasma torch is configured such that the feed gas delivered to the first cylindrical cavity is at a flow rate of 1 Ln/min-10 Ln/min. In embodiments, the plasma torch is configured such that the operation and configuration of the plasma torch is arranged to produce, in normal use, a total plasma plume fluence of at most 30W, or a total energy of 120 J over a 4-5 second dose. In embodiments, the plasma plume intensity produced will be at most 120 W/cm2.
The example embodiments presented herein provide a device with low plasma flow rate operated with low currents. Such operating parameters are suitable for the therapeutic treatment of tissue, such as skin and wounds, in vivo. In contrast, typical industrial plasma devices operate with the use of large current levels (e.g., approximately 50-100 A and well above) and large flow rates (e.g. 15-20 L/min and above) and extremely high fluences (300-500 W/cm2 and well above). Industrial plasma devices are typically utilized for melting or cutting hard materials such as metals. Industrial plasma devices do not produce a plasma suitable for use in the therapeutic treatment of tissue, such as skin and wounds, in vivo. Similarly, plasma scalpels produce plasma having very high fluences for cutting tissue and are not suitable for cosmetic and therapeutic treatment of skin. Rather, such industrial plasmas would cause irreparable damage to or indeed destruction of tissue, without being usable to provide any therapeutic benefit.
The example embodiments presented herein provide a plasma torch producing a stable, relatively low energy hot arc discharge plasma which operates with a current threshold of at most 5A and a gas flow rate of at most 10 Ln/min. Such operating parameters allow for the creating of a plasma which enables lower operational temperatures and a lower energy level (i.e., at most 100 J) and is therefore suitable for in vivo treatment of skin and/or wounds.
In embodiments, the central cathode rod further comprises a thermionically emissive material. In use, this helps to enhance the ionization of the feed gas between the cathode and grounded conductive tube.
In addition to the thermal plasma, plasma torches may further comprise a high voltage electrode having a dielectric barrier material at a radially inward-facing surface thereof and being arranged around the grounded conductive tube and spaced apart therefrom to form a second annular cylindrical cavity open at one end in which a dielectric barrier discharge between the high voltage electrode and grounded conductive tube can ionize a feed gas to produce a non-thermal plasma halo surrounding the central thermal plasma. However, an electrode arrangement to provide a non-thermal plasma halo surrounding the central thermal plasma preferably not provided. Indeed, in embodiments the plasma torch is provided with the electrode and feed gas components arranged to generate the thermal plasma only, and without any components for generating the non-thermal plasma. This leads to a relatively slim profile, high energy plasma torch.
The invention also provides means to vary the fluence and spot size of the thermal plasma. The cathode rod and grounded electrode are removable and replaceable with different cathode rods and grounded electrodes with differing geometries, thus allowing the energy of the thermal plasma to be varied further. In this way, the energy range achievable, and range of utility of the device, is extremely wide. Thus the plasma treatment system can be used to treat deep wrinkles and significant skin irregularities in a similar way to fractionated laser treatments (albeit with fewer side effects and on a more zonal basis as blending is easier), and also used to treat other areas of the skin for fine lines and wrinkles at lower energy levels. In addition, a low recovery period is achieved such that the procedure can be carried out by trained, non-medical personnel in a nonsurgical setting. Indeed, cosmetic treatments may be carried out using the present invention in which no anaesthetic is required.
The high energy thermal plasma is used to ablate tissue (e.g. layers of the epidermis, in a delayed fashion, to encourage rejuvenation and regeneration of the surface layers of the skin) and to thermally stimulate tissue (e.g. lower layers of the dermis to stimulate collagen formation)
The plume shape enables the torch to be used in cosmetic treatments somewhat like a paintbrush, to treat local areas to a varying depth and effect, providing a flexible finish that is easily blended locally and so usable to treat small areas or zones, particularly deep wrinkle areas such as crow's feet or frown lines, without having to treat a wide area of the skin. This is unlike laser treatment, which is more like a sharp pencil, or leaves a finish like a dot matrix pattern if fractionated, and so cannot be blended easily nor used to treat small zones of the skin alone. Instead, with laser treatment, typically the whole of the face or at least a wide area thereof will need to be treated. The present invention allows targeted local treatment of deep wrinkles and other significant local skin irregularities.
In preferred embodiments, the behaviour of the thermal plasma is dominated by fluid dynamics. The arc discharge acts as an intense source of heat and ionisation which is propagated in use towards the open end of the torch by the flowing feed gas. In this way, the thermal plasma is also guided towards the open end of the torch where it is then emitted.
In embodiments, the fluence and energy distribution of the thermal plasma can be controlled by manipulating the location and properties of the arc and the flow of the feed gas.
In other embodiments, the end of the cathode rod is recessed from the open end of the grounded conductive tube. In use, in embodiments where magnetohydrodynamic effects have a significant influence on the downstream distribution of the plasma, the arc discharge may cause a Lorentz force that accelerates the central thermal plasma towards a focal point in front of the open end of the plasma torch. The arrangement of the electrodes in this way causes a magnetic field generated in the first cavity by the current travelling through the grounded tube and the cathode (due to the arc discharge therebetween), with magnetic field lines flowing cylindrically around the cathode. This magnetic field itself has an effect on the charged thermal plasma generated by the arc discharge of producing a Lorentz force on the plasma, which, due to the recess of the cathode compared to the open end of the grounded tube, is directed towards the central common axis of the electrodes in front of the open end of the grounded tube. In this way, the thermal plasma may be accelerated towards a focal point in front of the open end of the torch, allowing the plasma to be concentrated, giving a high fluence in the resulting plasma plume. In this respect, the acceleration of the plasma by a magnetic field induced by a current generated by the arc discharge creates a magnetohydrodynamic effect on the plasma, meaning that the accelerated plasma can be considered a magnetohydrodynamic plasma. In different embodiments, the effect of this magnetic field on focussing the thermal plasma is more or less significant, although in embodiments it can be less significant than the thermal effects of convection of the plasma and other fluid dynamic effects.
In embodiments, the relative axial extent of the cathode and grounded tube at the open end of the plasma torch is configured such that the thermal energy of the resulting plasma plume is concentrated a given distance in front of the open end of the torch. The distance is determined by a combination of the position of the arc, the feed gas flow rate, and the size of the exit orifice.
Moreover, the relative positioning and configuration of the electrodes is set to give a desired plume characteristic. In embodiments, the cathode and grounded tube are relatively axially moveable to allow a user of the torch to adjust the given distance that the plasma plume is concentrated at the open end of the torch. In this way, the relative positioning and configuration of the electrodes is adjustable to allow the operator to adjust the plume shape and intensity, to achieve a desired plume characteristic. This allows the operator a great degree of flexibility and control over the operation and effect of the plasma torch, and can be considered akin to providing the operator with a variety of paintbrushes with which to rejuvenate different areas of the skin.
In embodiments, the end of the central cathode rod is recessed from the open end of the grounded conductive tube.
In embodiments, the open end of the grounded conductive tube comprises a lip which, in use, further focusses and/or centralises the central thermal plasma emitted from the open end of the first cavity. Focussing the plasma plume in this way gives a higher fluence and a greater effect on the tissue than a more dispersed, non-focussed plume. It is conceived that in use, the user may select from a range of detachable and interchangeable grounded tubes and cathode rods when deciding on the most suitable distribution of energy for a treatment. In embodiments, the lip geometry, such as size and shape, varies between different grounded conductive tubes to control, in use, the fluence, angular distribution, spot size and other characteristics of the central thermal plasma emitted from the open end of the first cavity. Moreover, varying the angle of the lip affects the flow dynamics of the feed gas and thus the downstream distribution of thermal energy produced by the arc can be manipulated. By providing an adjustable spot size and plume shape, the user can readily adapt the output plasma for different regions and conditions of the skin, like a palette of paintbrushes, allowing blending and bespoke treatments to be applied to small zones of the skin. Generally, the greater the fluence of the thermal plasma, the greater the depth of penetration and rejuvenation of the dermis.
Viewed from another aspect, the present invention provides a modular cathode assembly for a plasma torch in accordance with the aspects and embodiments of the invention described herein, the modular cathode assembly comprising a cathode and optionally a grounded tube and being configured to be detachably connectable to the plasma torch to enable the cathode thereof to be replaced. In embodiments, the grounded tube and cathode are together detachably connected to the torch as parts of a replaceable modular assembly.
In embodiments, the plasma torch and modular assembly have mutually cooperating screw threads to enable the detachable connections therebetween. In embodiments, the cathode assembly is attached to the hand piece by a spring-loaded bayonet mechanism. In use, the cathode assembly is attached to the hand piece by inserting it into the hand piece and turning clockwise whilst pushing against a spring. The cathode assembly is then pushed against the spring and turned anti-clockwise to release the assembly to remove it from the hand piece.
By providing the plasma torch with a modular construction having readily changeable modular parts for the ‘hot’ electrode section (including the cathode), if and when the electrodes become worn, they are readily replaceable without the need for disassembly of the torch by a service engineer. Instead, the worn electrode modular components can be removed by the end user, for example by unscrewing them from the torch, and replaced with new or reconditioned modular components. In embodiments where the modular high voltage electrode assembly is permanently contained within the hand piece, when the electrodes become worn, they may be replaced by a service engineer.
In embodiments, the plasma torch comprises one or more containers of feed gas connected to the plasma torch, wherein the apparatus is configured such that feed gas is supplied to the cavity to be ionized in use. In embodiments, the plasma torch further comprises: at least one feed gas inlet opening for the cavity; wherein the plasma torch is configured to provide sealed fluid communication between the feed gas inlet and a feed gas connector for connecting to a feed gas supply.
Viewed from another aspect, the present invention provides an electrical power generator unit coupled with and providing power in use to a plasma torch in accordance with the aspects and embodiments of the invention described above, comprising: means configured to provide to the central cathode rod in use a constant direct current (DC) electrical power supply plus a high voltage pulsed electrical power supply to initiate the arc discharge in the cylindrical cavity; and means configured to control the rate of flow of the feed gas into the cylindrical cavity which, in use, indirectly controls the fluence of the central thermal plasma emitted from the open end of the first cavity. In use, a constant direct current (DC) electrical power plus a high voltage pulsed electrical power is provided to the cathode producing an arc discharge in the cavity between the cathode and grounded tube to generate a thermal plasma emitted at an open end of the cylindrical cavity.
Viewed from another aspect, the present invention provides a control module configured in use to cause the plasma torch to generate a plasma plume in accordance with the aspects and embodiments of the invention described above. The control module may be implemented using hardware or hardware and software. There may be provided a data processing module and computer readable medium, optionally non-transitory, comprising instructions which when carried out by the data processing module configure the apparatus to implement the control module.
The electrical power generator unit and control module may be configured to operate the plasma torch using, for example appropriate currents, voltages and feed gas volumetric flow rates, so as to produce a stable plasma having a fluence as described herein.
Viewed from another aspect, the present invention provides an apparatus for generating a plasma plume, comprising: a plasma torch in accordance with the aspects and embodiments of the invention described above; and an electrical power generator unit in accordance with the aspects and embodiments of the invention described above coupled to the plasma torch.
Viewed from another aspect, the present invention provides an apparatus for generating a plasma plume, comprising: a plasma torch in accordance with the aspects and embodiments of the invention described above; an electrical power generator unit in accordance with the aspects and embodiments of the invention described above coupled to the plasma torch; and a control module in accordance with the aspects and embodiments of the invention described above coupled to the plasma torch.
Viewed from another aspect, the present invention provides a method for the cosmetic treatment of skin, comprising: generating a plasma in accordance with any of the methods of the present invention described herein, and directing the generated plasma plume at the skin requiring cosmetic treatment.
Viewed from another aspect, the present invention provides a method for the surgical treatment of tissue, comprising: generating a plasma in accordance with any of the methods of the present invention described herein, and directing the generated plasma plume at the tissue requiring surgical treatment.
Viewed from another aspect, the present invention provides a method for the sterilization of objects in an industrial process, comprising: generating a plasma in accordance with any of the methods of the present invention described herein, and directing the generated plasma plume at the objects requiring sterilization. The sterilizing and heating effects of the plasma generated by methods of the invention described herein has be found to have particular utility in the sterilization of objects, for example in industrial processes.
Viewed from another aspect, the present invention provides use of a plasma torch or an apparatus in accordance with the aspects and embodiments of the invention described herein in the cosmetic treatment of skin, optionally for one or more of: wrinkle removal; skin resurfacing; skin ablation; scar removal; hair removal.
Viewed from another aspect, the present invention provides use of a plasma torch or an apparatus in accordance with the aspects and embodiments of the invention described herein in non-surgical treatment.
Viewed from another aspect, the present invention provides use of a plasma torch or an apparatus in accordance with the aspects and embodiments of the invention described herein in surgical treatment of live tissue, optionally for one or more of: cauterization; tissue ablation for wound healing; wound or burn sterilization; cavity sterilization.
Viewed from another aspect, the present invention provides use of a plasma torch or an apparatus in accordance with the aspects and embodiments of the invention described herein in an industrial sterilization process, optionally for sterilizing one or more of: foodstuffs; pharmaceuticals; medical implants; medical instruments; surfaces and industrial components.
Viewed from another aspect, the present invention provides a plasma torch or an apparatus in accordance with the aspects and embodiments of the invention described herein for use in the cosmetic treatment of skin, optionally for one or more of: wrinkle removal; skin resurfacing; skin ablation; scar removal; hair removal; treatment of rosacea and acne.
Viewed from another aspect, the present invention provides a plasma torch or an apparatus in accordance with the aspects and embodiments of the invention described herein for use in surgical treatment of live tissue, optionally for one or more of: cauterization; tissue ablation for wound healing; wound or burn sterilization; cavity sterilization.
Viewed from another aspect, the present invention provides a plasma torch or an apparatus in accordance with the aspects and embodiments of the invention described herein for use in an industrial sterilization process, optionally for sterilizing one or more of: foodstuffs; pharmaceuticals; medical implants; medical instruments; surfaces.
The optional features of the first aspect of the present invention can be incorporated into any other aspect of the present invention and vice versa.
Aspects of the invention may best be understood by reference to the following description of certain exemplary embodiments together with the accompanying drawings in which:
The detailed description set forth below in connection with the appended drawings is intended as a description of presently preferred embodiments of the invention, and is not intended to represent the only forms in which the present invention may be practised. It is to be understood that the same or equivalent functions may be accomplished by different embodiments that are intended to be encompassed within the spirit and scope of the invention. Furthermore, terms “comprises,” “comprising,” or any other variation thereof, are intended to cover a non-exclusive inclusion, such that apparatuses and method steps that comprises a list of elements or steps does not include only those elements but may include other elements or steps not expressly listed or inherent. An element or step proceeded by “comprises . . . a” does not, without more constraints, preclude the existence of additional identical elements or steps that comprises the element or step
Referring now to
Once the gas is flowing into the plasma torch 101 through the feed gas connectors 102 and 108, the controller causes a power supply (not shown) to generate one or more different electrical power signals that are provided via power supply cabling (not shown) to one or more electrodes in the plasma torch 101 to cause electrical discharge inside the plasma torch 101. A grounded rod 104 is also provided to act as the ground reference for the grounded components of the plasma torch 101. The feed gas inside the plasma torch 101 is then ionised by the discharge and is emitted from an open end 109 of the plasma torch 101 in the form of a two-stage plasma plume: a higher energy central focused thermal plasma emitted from opening 105, and a surrounding lower energy non-thermal plasma halo emitted from opening 106, as will be described in more detail below. The plasma plume may be generated for a sustained period of time or may be caused to be emitted in pulses. The outer, non-thermal plasma halo may be ignited alone or in addition to, the central, thermal plasma.
According to some of the example embodiments, the apparatus is typically supplied a current fixed during plasma generation (by control) to be in the range of 2A to no more than 5A. Specifically, a current of at most 5A, at most 4.8A, at most 4.6A, at most 4.4A, at most 4.2A, at most 4A, at most 3.8A, at most 3.6A, at most 3.4A, at most 3.2A, at most 3A, at most 2.8A, at most 2.6A, at most 2.4A, at most 2.2A, or at most 2A may be used. According to some of the embodiments, the current is an arc current between the central cathode rod and grounded conductive tube, where the arc current preferably being fixed during plasma production. Such a current range may be beneficial in producing the hot arc plasma to have a temperature and energy at a level at which the plasma is suitable for therapeutic treatment of tissue in vivo. In particular, the temperature of the plasma which will be placed on the treatment surface will be suitable for exposure to live tissue without irreparable thermal damage.
According to some of the example embodiments, a gas flow of 1-10 Ln/min is employed. Specifically, it should be appreciated that a flow rate of at most 10 Ln/min, at most 9 Ln/min, at most 8 Ln/min, at most 7 Ln/min, at most 6 Ln/min, at most 5 Ln/min, at most 4 Ln/min, at most 3 Ln/min, at most 2 Ln/min, or at most 1 Ln/min may be used. According to some of the embodiments, the feed gas delivered to the first cylindrical cavity comprising a flow rate as discussed above. Such a range of flow rates may be beneficial in stabilizing the generation of the relatively low energy hot plasma generated at a fixed plasma current in the range of at most 5A. Specifically, the flow rate of 1-10 Ln/min stabilizes the plasma such that the plasma does not prolapse out of the cavity, thus significantly reducing the occurrence of oxidation and corrosion of the electrodes, which would otherwise inhibit the formation of the arc, preventing the device from being turned off and on, and shortening the useful life of the torch components.
One reason for operating at such low flow rates and currents, as compared to industrial plasma based devices, is to ensure the amount of heat imparted to the gas is suitable for use on skin or a wound. Such operating conditions also ensure the plasma is stable and forms with the electrode arrangement, thereby creating a consistent spot size and energy profile. The operating conditions further aid in reducing the amount of oxygen that gets into the plasma. Too high a flow rate and/or too high a current increases the potential of plasma instability and oxidation of the electrodes which may prevent the ability to turn the apparatus on and off with any reliability, compared to low plasma currents and flow rates.
According to some of the example embodiments, operating parameters comprising an upper threshold of at most 5A and a flow rate of at most 10 Ln/min may produce, at a distance of around 25 mm from the open end 109, a plasma plume with an energy distribution giving a spot size of approximately 0.5 cm across, or spread over 0.25 cm2. Generally, the operation and configuration of the plasma torch in accordance with embodiments will be arranged to produce a total plasma plume fluence of at most 30W, or a total energy of 120J over a 4-5 second dose.
Generally, the plasma plume intensity produced will be at most 120 W/cm2. It should be appreciated that the energy level may be determined with the use of a calorimeter, such as a solid state uncooled calorimeter.
An operator of the apparatus 100 can manipulate the plasma torch 101 to direct the plasma plume emitted from opening 109 onto tissue to carry out cosmetic or surgical procedures. For example, the plume may be used for the cosmetic treatment of deep wrinkles such as crow's feet and other, significant skin irregularities.
The components of the plasma torch 101 in the front half F are encased in a grounded stainless steel casing 1. The casing 1 is tubular and tapered in form, with the front end of the casing 1, comprising the opening 109, having a smaller diameter than the rear end of the casing 1. The tapered shape of the casing 1 gives the operator an increased field of vision, such that the operator has improved visibility of the area requiring treatment. This has particular benefit in treatments requiring a higher level of precision, where the operator requires a clear view of where the plasma plume is contacting the surface requiring treatment.
A grounded stainless steel body 31 forms the rear end R of plasma torch 101. Threaded portions (not shown) may be provided on casing 1 and stainless steel body 31 to allow the front F and rear R parts of the torch to be mated. The body 31 has towards its front end a solid block machined into a perforated bulkhead 32 that acts to retain certain other components of the plasma torch 101 and to admit feed gas and electrical coupling wires from the rear to the front of the plasma torch 101. A grounded rod 104 is provided in the rear part of the plasma torch 101. A bore 20 in the bulkhead 32 forms a cavity sized to receive the grounded rod 104, which acts as the ground reference for the grounded components of the plasma torch 101.
A cathode rod 2, formed of either tungsten, lanthanated tungsten, ceriated tungsten or thoriated tungsten, is provided in the front half of the plasma torch 101 to extend along the central axis thereof. Arranged coaxially around the cathode rod 2 and spaced apart therefrom, there is provided a grounded stainless steel arc tube 3. A cylindrical annular cavity 33 formed between the rod 2 and the grounded tube 3 is open at its front end 105 but it is sealed at its back end, except for feed gas inlets. As will be explained in greater detail below, in use, the cathode rod 2 is provided with an electrical power signal sufficient to create an arc between the cathode rod 2 and the grounded tube 3 which is used to generate a ‘hot’ thermal plasma in the cylindrical annular cavity 33 that is then emitted from the open front end 105 of the cavity 33.
It should be noted that the axial extent of the cathode rod 2 at the front end thereof is recessed relative to the open end of the front of the grounded tube 3. This relative positioning causes a force to be generated by the fluid dynamics of the flowing feed gas in use, which causes the central thermal plasma to be accelerated towards the central axis of the plasma torch 101 causing the hot stage of the plasma plume to become focused. As will be discussed in more detail later, the grounded tube 3 comprises a lip 9, which acts to restrict the opening 105, and in use helps to control the fluence of the thermal plasma, to collimate and focus the thermal plasma onto the treatment surface, and also to control the angular distribution of the thermal plasma emitted from the open end 105 of the plasma torch 101.
The cathode rod 2 comprises an emissive material, and is tapered, or pointed, in form at the front end nearest the opening 105, thus allowing the location of the arc discharge on the cathode rod 2 to be, in use, fixed at the pointed end of the cathode 2. Such a pointed end may allow repeatability of the location of the arc discharge since electric field lines are concentrated at sharp points and edges, which locally increases the likelihood of electrical breakdown. Furthermore, a sharpened emissive cathode may also benefit from a faster warm-up period, due to the concentration of heating at the pointed tip of the cathode rod.
Arranged coaxially around the grounded tube 3 and spaced apart therefrom is a Borosilicate glass or ceramic (Boron Nitride/Alumina) tube 5 that has a dielectric constant of around 4.6 and that acts as a dielectric barrier to a high-voltage copper electrode 6 arranged radially outwardly thereof. A second cylindrical cavity 34 is formed between the grounded tube 3 and the dielectric barrier tube 5 that is open at its front end but is sealed at its back end by bulkhead 32, except for inlets formed by bores 20 in the bulkhead 32 that enable the passage of feed gas, and a coaxial power supply cable 8 from the rear R to the front F of the plasma torch 101. In use, the high-voltage electrode 6 is provided with an electrical power signal sufficient to create a dielectric barrier discharge between the dielectric barrier tube 5 and the grounded tube 3 which is used to generate a ‘cold’ non-thermal plasma in the cylindrical annular cavity 34 that is then emitted from the open front end 106 of the cavity 34. The high-voltage electrode 6 is connected to a brass threaded rod 7 acting as a high voltage connector and having a conductive core of a coaxial cable 8 soldered to it. In use, the coaxial cable 8 conducts the high-voltage electric power signal generated by a power supply to the high-voltage electrode 6.
A ceramic (Boron Nitride/Alumina) block 12 is arranged to extend around the high-voltage electrode 6 to electrically and thermally insulate the high-voltage electrode 6 from all other grounded metal surfaces. A bore is formed on the block 12 to receive the coaxial cable core 8 for connection to the high-voltage electrode 6 via the high-voltage connector 7. A further bore (not shown) is formed in the block 12 to receive a thermocouple (not shown) arranged to monitor temperature of the high-voltage electrode 6 in use to ensure that it does not overheat. Holes are provided through the bulkhead 32 registered to the bores provided in the block 12 for passing the thermocouple and coaxial cable from the rear to the front of the plasma torch 101.
To the rear of the bulkhead 32, there is provided a large central bore that contains a brass cathode connector 16. A bore in the brass cathode connector 16 forms a cavity sized to receive a stainless steel cathode base 15 with an interference fit therein. The cathode 2 is supported by and extends from the cathode base 15 to the front of the plasma torch 101, via a bore in the bulkhead 32.
The grounded tube 3 has on its radially outward facing surface a screw thread 14 that mutually co-operates with a screw thread 14 provided on a radially inner surface of a central bore of the bulkhead 32, such that the grounded tube 3 is releasably engageable with the grounded steel body 31 and is grounded thereby in use.
In the embodiment, a replaceable “cold tip” module is provided by the grounded casing 1 and comprises at least the dielectric tube 5 and high-voltage electrode 6. These components are provided together in a single assembly that is releasably engageable with the body of the plasma torch 101. A replaceable “hot tip” module is provided by the cathode 2, grounded tube 3, and cathode base 15. These components are provided together in a single assembly that is releasably engageable with the body of the plasma torch 101.
The cold tip and hot tip modules can be easily replaced by the user to service the plasma torch 101 when the electrodes thereof become worn. In other embodiments, the cold tip, which includes the high-voltage electrode 6 at least, and the hot tip, which includes the cathode 2 at least, may be constructed differently and have different components in the assembly to that shown for the embodiment described in detail in
To the rear of the rear end R of the plasma torch 101, the plasma torch 101 is sealed by a radially extending feed through plate 24 having holes therethrough and connectors for interfacing with a power supply and a gas supply. Both feed gas connectors 102, 108 extend through the holes provided in the feed through plate 24.
To the rear of the bulkhead 32, a chamber 23 is provided which is closed at the rear end by the cathode base 15, except for an outlet from feed gas connector 108. The gas supplied to ionisation cavity 33 for production of the “hot” thermal plasma is fed from the feed gas supply to cavity 33 via feed gas connector 108, which mates with the cathode base 15. In use, the feed gas supply for the central, thermal plasma to be ionised in cavity 33 is connected to feed gas connector 108. A fluid communication channel is thereby provided between the feed gas connector 108 and the cavity 33 via grooves provided through the stainless steel cathode base 15 that allow the feed gas to pass from cathode base 15 into chamber 23 and then from chamber 23 through into the cavity 33 formed in the space between the cathode rod 2 and the grounded tube 3.
The gas supplied to ionisation cavity 34 for production of the “cold” non-thermal plasma is fed from the feed gas supply to cavity 34 via feed gas connector 102. The “cold” feed gas connector 102 extends through a hole in the feed through plate 24, and through a hole, or bore, in the bulkhead 32. In use, the cold feed gas supply for the non-thermal plasma to be ionised in cavity 34 is connected to the feed gas connector 102. Nitrile O-rings (not shown) arranged between the feed through plate 24 and the body 31 provide a seal between the external atmosphere and the interior of the device when under compression. A bore (not shown) in the bulkhead 32 provided between feed gas connector 102 and cavity 34 provides a fluid communication path for the cold feed gas from feed gas connector 102 at the rear R of the plasma torch 101 to the front of the plasma torch 101.
The bore accommodating the “cold” feed gas connector 102 also performs the function of providing a passageway for the high-voltage coaxial cable 8 that extends from a hole in the feed through plate 24 at the rear of the plasma torch 101, through feed gas connector 102, through the bore 20 in the bulkhead 32, and through a bore in the ceramic insulator 12. At the front of the bore in the ceramic insulator 12 the conductive core of the coaxial cable 8 is connected to the high-voltage electrode 6 by a high-voltage connector 7. In this way, a conductive connection is formed between the high-voltage electrode 6 and a power supply via electrical power cabling (not shown).
To connect a power supply (not shown) to the cathode 2, single core wires extending into the plasma torch 101 via holes in the feed through plate 24 are soldered to the cathode connector 16. In this way, a conductive connection is formed between the cathode 2 and a power supply via electrical power cabling.
In the embodiment shown in
Screw 107 is engaged with the bulkhead 32 in the rear end R of the plasma torch 101. Threaded portions (not shown) are provided in a bore in the bulkhead 32, the bore extending through the body 31 and connecting a radially outward facing surface of the body 31 to a radially outward facing surface of the grounded tube 3. The bolt also comprises a threaded portion which allows the bolt 107 to mate with the bore in the bulkhead 32 in use. When fully mated, the bolt 107 extends from the radially outward facing surface of the body 31 to the radially outward facing surface of the grounded tube 3, and makes contact with the grounded tube 3. In use, the screw 107 provides a ground connection to the body 31.
A replaceable “hot tip” module 242 is provided by the cathode rod 241, grounded tube 203, and cathode base 215. These components are provided together in a single assembly that is releasably engageable with the body of the plasma torch 201 by means of a spring-loaded bayonet mechanism.
The spring-loaded bayonet mechanism comprises a threaded retainer 240 for attaching the mechanism to the plasma torch 201, spring 244 and retaining bayonet pins 246. In use, the hot tip module 242 is inserted into the plasma torch 201 and passes the bayonet pins 246 due to appropriately shaped channels 245 (such as V-shaped channels) in grounded tube 203. The module 242 is then pushed against the spring 244 and the channels 245 engage with the bayonet pins 246. Whilst pushing, the hot tip module 242 is then turned clockwise to lock the module 242 in place. When in the locked position, an electrical connection is made between the cathode base 215 and a high voltage cable 248 supplying power to the cathode rod 241 in use.
To remove the hot tip module 242, the module 242 is pushed against the spring 244 and turned in an anti-clockwise direction to disengage the module 242 from the bayonet pins 246, and thus releasing the module 242 from the plasma torch 201.
In some embodiments, each bayonet pin 246 has identical dimensions, that is each bayonet pin 246 is the same size. In some embodiments, each bayonet pin 246 has different dimensions, that is a different size, such that the hot tip module 242 can only be inserted in one orientation.
Operation of the apparatus 100 to generate the two-stage cooperative plasma plume will now be described with reference to
In order to begin production of the two-stage plasma, the gas supply in the system control unit is caused by the controller in response to user operation of the controls to begin releasing feed gas under pressure to the first 33 and second 34 cavities via a gas supply conduit (not shown). Then the controller causes the power supply to generate electrical power signals which are provided to the cathode 2 and high-voltage electrode 6 via the electrical power cabling.
The thermal plasma then concentrates at a concentration point P in front of the plasma torch 101. The concentration point P is located on the tissue requiring treatment 50, such as skin. As a result, the apparatus 100 achieves a significantly improved tissue resurfacing, regenerating and rejuvenating effect compared to known plasma tissue resurfacing devices, improving patient outcomes in both cosmetic and surgical tissue treatments. Indeed, the patient outcomes achieved by the apparatus 100 are comparable in order to the known laser systems, described above, without any of the attendant disadvantages like the pin-prick patterning on the skin. Instead, the finish on skin for cosmetic treatments using the two-stage plasma is smoother and more easily blended such that cosmetic treatment of smaller “zones” of the skin is enabled while still providing a homogeneous surface finish.
The plasma generation system 100 may be configured such that, in use, the spot size and shape of the plume may be adjustable. Characteristics of the plasma 601 such as the fluence and the spot size at the concentration point P, can be altered depending on the characteristics and dimensions of the lip 9, and resulting size and dimensions of the open end 105. The fluence may also be manipulated by varying the distance, or recess, between the pointed tip of the cathode rod 2 and the lip 9.
Depending on the distribution of energy required to treat the tissue 50, it is desirable that the operator of the plasma torch 101 can vary the geometry of the cathode rod 2 and the lip 9. A metric useful for assessing the energy of the plasma 601 is fluence, defined as the energy of the plasma 601 (Joules, J) divided by the area of the incident spot on the treatment surface 50 (in cm2). The area of the incident spot on the treatment surface 50 is related to the area of opening 105. Generally, the greater the fluence of the plasma 601, the greater the depth of penetration and rejuvenation of the dermis.
One way to manipulate the fluence, and thus the spatial distribution of the energy delivered to the treatment surface 50, is by varying the location and dimensions of the arc discharge 41. This can be achieved by altering the recess 43 between the pointed tip of the cathode rod 2 and the lip 9, and the separation 42 between the tip of the cathode rod 2 and the grounded tube 3. Adjusting and fine tuning the relative axial positioning of the front ends of the cathode 2 and grounded tube 3 alters the directionality of the forces that act on the thermal plasma, and consequently alters the fluence of the plasma 601, as well as altering the concentration distance P and spot size on the treatment surface 50. The axial positioning can be manipulated by, for example, providing a user-controllable electrode geometry alteration mechanism in the plasma torch, such as a mechanical scroll wheel, or by means of controls.
The fluence, spot size, and other characteristics of the plasma 601 may also be manipulated by varying the geometry of the lip 9, for example the width 45 of the resulting opening 105 and the depth 44. A larger lip depth 44 can help to collimate and focus the plasma 601 on the treatment surface 50.
The radial extent of the lip 9 from the grounded tube 3 towards the central axis of the plasma torch 101 determines the width 45 of the resulting opening 105. Furthermore, the end of the lip 9 defining the opening 105 may be flat, or in some embodiments it may be angled, thus allowing the angular distribution of the plasma 601 to be manipulated. An angled lip 9 results in a plasma 601 which is emitted from the plasma torch 101 towards a concentration point located at a distance away from the central axis of the plasma torch 101. This may provide some benefit because it may provide an operator with improved visibility of the plasma 601 and the tissue being treated which could be useful where a higher level of precision is required when treating the surface 50.
Since fluence is determined by the energy of the plasma divided by the area of the opening 105, a smaller width 45 will result in a higher fluence whereas a larger width 45 will result in a smaller fluence, for the same plasma energy. Therefore, a smaller width 45 allows a more highly focused, higher-energy plasma 601, with a much smaller, more centralised, spot size which is particularly suited in treatments requiring a high level of precision, such as where the treatment area is very small, for example deep laughter line wrinkles formed around the mouth. Furthermore, a high fluence enables a more penetrative effect on the tissue 50, thus allowing deeper layers of tissue, such as skin, to be treated.
On the other hand, a larger width 45 results in a less focused, lower-energy, plasma 601, with a much larger, less centralised, spot size. The larger spot size may be around 1-2 mm away from the concentration point P, which lies on the central axis of the plasma torch 101. It is more difficult to precisely target specific areas for treatment using a larger spot size, instead they are more suited to treating larger areas of tissue with little precision, such as blending treated laughter lines and to treat wider areas of fine wrinkles, such as crow's feet around the eyes.
It is conceivable that the user could select from a range of detachable and interchangeable tubes when deciding on the most suitable distribution of energy for a treatment, and install these tubes with bespoke tooling before a procedure. For example, there are a variety of different detachable tubes with different lip widths and depths, and also different lip angles, which can be selected from when deciding on the distribution of energy required.
Further controls may be provided in the plasma control system operable, for example, from the control panel which may allow the user to adjust the spot size or plume geometry by causing the feed gas pressure to be increased or decreased or providing a power supply unit operable in use to enable increasing or decreasing or otherwise changing the power supply waveforms to the electrodes to generate the one or both of the two plasma stages. Finely adjusting these parameters individually or in combination, particularly with the electrode and lip geometries discussed above, allows a variety of spot sizes and plume geometries to be achievable, allowing the plasma generation device to provide a palette of plasma plumes usable in a variety of different ways to facilitate treatment of different wrinkles and skin irregularities, and to facilitate blending.
As shown in
As shown in
When the cooperative plasma plume 610 is used to rejuvenate skin tissue and to treat deep wrinkles and other significant skin irregularities, the ablated surface layers of the tissue are not immediately vaporised and are instead caused to disintegrate and slough off over the course of a few hours to days. In the meantime, the heating and trauma caused to the subsurface epidermal and dermal layers that encourage collagen and elastin production and rejuvenation are sterilised by the plume and protected by the remaining surface epidermal layers, thus reducing the likelihood of subsequent infection by bacteria found on the skin. In some embodiments, the traumatised subsurface layers may be provided with an in situ sterile dressing that may significantly promote healing and improve the recovery time while minimising the side-effects and downtime of the rejuvenating skin treatment.
In order to use the plasma plume 610 for cosmetic or surgical treatment, the operator would initiate the plasma plume and move the tip of the plasma torch 101 along the treatment area of the tissue at a fixed distance, in a “paintbrush” fashion, to achieve the desired effect and outcome. This distance is controlled using disposable “patient interface tubes” that allow the user to see the area and the plume of the device. For cosmetic, non-surgical use of the plasma to reduce wrinkles and rejuvenate skin, the cosmetic treatments may be performed by appropriately trained, non-medical personnel (such as a cosmetic technician) in a non-medical setting as the treatment is non-invasive and poses minimal health risks and side effects as the plasma plume itself provides a sterile dressing. For purely cosmetic treatments, the operator need not be a skilled medical professional. However, for wound debridement and for stimulating regeneration of tissue for medically curative purposes, or for cauterisation in a surgical setting or as part of a wider surgical intervention, the two-stage plasma plume will need to be operated by a medical professional.
A trigger control (not shown) may be provided on the plasma torch to initiate the release of the feed gas and the activation of the power supply by the system control unit in order to produce the co-operative plume on-demand (or just the non-thermal plasma, or just the thermal plasma) by the operator. The apparatus may be configured such that the trigger mechanism may cause the plasma plume to be constantly generated for as long as the trigger is depressed. Alternatively, the apparatus may be configured such that a short blast or pulse of plasma is generated in response to depressing of the trigger. Repeated operation of the trigger may then be necessary in order to produce plasma pulses for use in cosmetic and surgical treatments. The energy to be delivered to the surface will be controlled on the base unit.
It should be appreciated that all dimensions illustrated in
While the foregoing embodiments are example plasma torches described as having the surrounding cold stage of plasma and having orifices having aspect ratios of length to width of 1:1 or, in the case of the
Referring now to
The orifice is configured to wick thermal energy away from the thermal plasma or plasma effluent before it is emitted from the opening in the grounded conductive chamber. Although not shown, in other embodiments, the cross section of the orifice may vary along its length to change the surface area of the wicking region.
As a result of the lengthened and narrowed orifice, although not shown, in other embodiments the cathode may not be pointed or tapered. Indeed, the cathode may have a rounded or flattened or non-pointed end.
As can be seen, the plasma torch of
As the plasma is produced inside the cavity in the
Although not shown, a plasma active cooling mechanism may be provided. This is to further cool the thermal plasma emitted from the torch. This may be achieved by providing a mechanism for cooling the feed, for example, to cryogenic temperatues, or by mixing the produced plasma with a cooled gas. This further facilitates the reliable application of a favourable plasma to a patient.
In some embodiments, while the cathode rod may comprise tungsten, in other embodiments, the cathode rod may further comprise a material resilient to operation using non-inert feed gases. Such a material may be Lanthanum Hexaboride.
In some of the embodiments, the second arc hot spot is created pinned on the discontinuity between the frustoconical surface 9a and inner surface 9b of the lip 9. The length of the inner surface 9b serves to collimate and obscure the hotspot from exposure to the treatment surface, which aids in reducing the radiative heat exposure therefrom and thus in keeping the temperature produced by the formation of the plasma down thereby making the in vivo treatment comfortable for a patient. The plasma is thus formed in the section of the lip forward of the entrance to the lip, where the arc occurs. The plasma plume is then passed along the inner surface 9b of the lip 9 and ejected from the orifice by gas pressure, on towards the tissue. The endpiece 3a or lip section of an integrally formed grounded tube acts as a heat sink, wicking heat away from the hot plasma by the interfacing of the plasma and the inner surface 9b of the lip. This can serve to cool the hot plasma to a temperature suitable for treatment of the tissue. The inner surface is in embodiments at least 3 mm long, in other embodiments, it is at least 4 mm long, at least 5 mm long, at least 6 mm long, at least 7 mm long, or at least 8 mm long.
According to some of the example embodiments, a spacer (not shown) may be provided on the plasma torch towards an end of the lip portion. The spacer provides a constant and minimum operational distance between the opening 105 and the treatment surface (i.e., skin or wound). By creating a constant and minimum operational distance, the spot size and energy of the plasma by be kept constant during the treatment, and also limited to prevent too high a dose at smaller spot areas that would be produced by the plume between the opening 105 and the end of the spacer. According to some of the example embodiments, the spacer may be arranged to define a minimum treatment distance of at least 10 mm, at least 15 mm, at least 20 mm or at least 30 mm from the treatment surface or at most 50 mm, at most 40 mm, or at most 30 mm from the treatment surface. It should be appreciated that the further the distance from the opening 105 and the treatment surface, the greater the spot size of the plasma due to dissipation of the plume, and so the lower the treatment dosage (or energy level) of the plasma will be per unit area of the tissue surface.
According to some of the example embodiments, the device may comprise a timer used to ensure a consistent treatment time (e.g., of approximately 4 seconds) on the treatment surface. The timer may serve to limit the maximum plasma energy dose applicable to tissue in one operation of the device, which may serve to enable an operator to meter the treatment to areas of the tissue. It should be appreciated that treatment times will vary depending on the produce, patient and specific operating parameters used by the device.
The description of the preferred embodiments of the present invention has been presented for purposes of illustration and description, but is not intended to be exhaustive or to limit the invention to the forms disclosed. It will be appreciated by those skilled in the art that changes could be made to the embodiments described above without departing from the broad inventive concept thereof. It is understood, therefore, that this invention is not limited to the particular embodiment disclosed, but covers modifications within the scope of the present invention as defined by the appended claims.
| Number | Date | Country | Kind |
|---|---|---|---|
| 1715216.6 | Sep 2017 | GB | national |
