Claims
- 1. A non-native peptide comprising the sequence
- 2. The peptide according to claim 1, wherein;
X2X3 are selected from the group consisting of DN, and —.
- 3. The peptide according to claim 1, wherein;
X12X13 are selected from the group consisting of LL, LF, FF, and LY.
- 4. The peptide according to claim 2, wherein;
X12X13 are selected from the group consisting of LL, LF, FF, and LY.
- 5. The peptide according to claim 4, wherein;
X10 is selected from the group consisting of L, and V.
- 6. The peptide according to claim 5, wherein;
X36 is selected from the group consisting of R, H, and Q.
- 7. The peptide according to claim 6, wherein;
X40 is selected from the group consisting of H and R.
- 8. The peptide according to claim 1, selected from the group consisting of SEQ ID NO: 324, 328, 331, 333, 334, 341, 384, 385, 386, and 387.
- 9. A method of preventing or treating a CRF2R modulated disorder comprising administering to a host in need of such treatment a safe and effective amount of a peptide of claim 1.
- 10. The method according to claim 20, wherein the CRF2R modulated disorder is skeletal muscle atrophy or a form of muscular dystrophy.
- 11. An isolated nucleic acid encoding a peptide of claim 1.
- 12. An isolated antibody specific for a peptide of claim 1.
- 13. A pharmaceutical composition comprising:
a. a safe and effective amount of a peptide of claim 1; and b. a pharmaceutically acceptable carrier.
- 14. A kit for preventing or treating a CRF2R modulated disorder comprising:
a. a peptide of claim 1 in a unit dose form; and b. usage instruction.
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority from U.S. Provisional Applications Serial Nos. 60/349,117, filed Jan. 16, 2002, 60/376,337, filed Apr. 29, 2002, 60/388,895 filed Jun. 16, 2002, and 60/411,988 filed Sep. 19, 2002, all of which are herein incorporated by reference in their entirety.
Provisional Applications (4)
|
Number |
Date |
Country |
|
60349117 |
Jan 2002 |
US |
|
60376337 |
Apr 2002 |
US |
|
60388895 |
Jun 2002 |
US |
|
60411988 |
Sep 2002 |
US |