Crystal structure of a Ras-P13K complex

BACKGROUND

[0002] The present invention relates to a crystal structure for phosphoinositide (PI) 3-kinase (PI3K) and/or Ras. In particular, the present invention relates to a crystal structure for an PI3K:Ras complex and the use of the crystal structure to identify ligands capable of binding to PI3K and/or Ras, and/or capable of modulating the interaction between PI3K and Ras.

[0003] The phosphoinositide 3-kinases (PI3Ks) are a family of ubiquitous multidomain signalling proteins which phosphorylate the 3-hydroxyl of phosphoinositides. Mammalian PI3Ks are divided into three classes based on their structure and substrate specificity (Domin and Waterfield, 1997). Class I enzymes are divided into two subclasses by the nature of a tightly associated regulatory subunit. The Class IA PI3K enzymes (p110, α, β, and δ isozymes) interact with an adaptor/regulatory subunit essential for their activation by receptor or non-receptor tyrosine kinases (reviewed in (Vanhaesebroeck and Waterfield, 1999). The sole class IB enzyme, PI3Kγ, binds a p101 subunit that is necessary for heterotrimeric G protein stimulation of phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3) production (Stoyanov et al., 1995; Stephens et al., 1997).

[0004] The products of PI3Ks, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and PtdIns(3,4,5)P3 affect a variety of targets (Toker and Cantley, 1997). In many cases, the 3-phosphorylated lipids act as tethers to recruit downstream effectors to the membrane. Cellular processes in which PI3Ks play an essential role include suppression of apoptosis (Franke et al., 1997), reorganisation of the actin cytoskeleton (Rodriguez-Viciana et al., 1997), cardiac myocyte growth (Shioi et al., 2000), glycogen synthase stimulation by insulin (reviewed in (Shepherd et al., 1998), TNFα-mediated neutrophil priming and superoxide generation (Condliffe et al., 1998), and leukocyte migration and adhesion to endothelial cells (reviewed in (Wymann et al., 2000).

[0005] Because of the significant physiological consequences of PI3K activation, these enzymes are under tight regulatory control, which affects both their substrate specificity and activity. For class I PI3Ks this regulation is achieved by direct interaction of the p110 catalytic subunit with a small number of regulatory proteins. The α, β, and δ PI3Ks associate with an SH2 domain-containing subunit (p85α and splice variants of it, p85β or p55γ) that is indispensable for activation by phosphorylated tyrosine kinases (Carpenter et al., 1993). PI3Kγ is regulated by association with Gβγ subunits of heterotrimeric G proteins. Although Gβγ can bind directly to the p110γ catalytic subunit, a p101 regulatory subunit that tightly associates with p110γ is critical for Gβγ-activated PtdIns(3,4,5)P3 production (Stephens et al., 1997; Krugmann et al., 1999; Maier et al., 1999). PI3Kβ can also be activated by interaction with Gβγ subunits, and this activation is synergistic with activation by phosphotyrosine peptides (Kurosu et al., 1997; Maier et al., 1999; Murga et al., 2000). Another class of potent activators of PI3Ks is the Ras family of small G proteins. All class I PI3Ks bind Ras in a GTP-dependent manner (Rodriguez-Viciana et al., 1994; Rubio et al., 1997; Vanhaesebroeck et al., 1997; Deora et al., 1998).

[0006] The Ras family of membrane localised GTPases transduce a variety of signals in eukaryotic cells (Lowy and Willumsen, 1993; Shields et al., 2000). The exchange of GDP for GTP causes two regions of Ras, known as switch I (residues 32-40) and switch II (residues 60-76), to change conformation (Pai et al., 1989; Milburn et al., 1990). This GTP-induced conformational change allows Ras to bind and activate multiple downstream effectors, which can cooperate to produce the diverse phenotypes characteristic of Ras transformation (White et al., 1995; Marshall, 1996) or function independently in activating survival pathways (Xue et al., 2000). Most of the Ras-dependent signalling is mediated by three downstream effectors: the protein kinase Raf, the exchange factor RalGDS, and PI3K (reviewed in (Wittinghofer and Herrmann, 1995; Feig et al., 1996; Rodriguez-Viciana et al., 1996a).

[0007] Although all class I PI3Ks bind Ras, only PI3Kα has been shown to be directly stimulated by Ras.GTP interaction (Rodriguez-Viciana et al., 1994; Rodriguez-Viciana et al., 1996b). Ras-induced activation is synergistic with p85-mediated stimulation of PI3Kα activity by phosphotyrosine peptides. Both stimuli are probably required to achieve optimum PI3K activation in response to extracellular signals. Direct Ras activation of PI3Kα stimulates actin rearrangement and inhibits programmed cell death upon detachment from the extracellular matrix (anoikis) (Khwaja et al., 1997; Rodriguez-Viciana et al., 1997). Ras mutants that activated Raf and RalGDS but not PI3K were incapable of blocking anoikis or stimulating cytoskeletal rearrangement. Other consequences of Ras activation of PI3Ks include cell transformation (Gire et al., 2000), T cell adhesion and migration (Tanaka et al., 1999) and blocking of apoptosis induced by c-Myc (Kauffmann-Zeh et al., 1997) or by NGF deprivation (Xue et al., 2000).

[0008] Accordingly, control of Ras activation of PI3K has implications in the control of leukaemias, metastatic cancer and other tumours. The use of small molecules for the inhibition of oncogenic Ras-Raf association has been discussed previously (Barnard et al., (1998) BBRC 247:176-180) and the use of short peptides derived from the H-Ras effector region for this purpose demonstrated. However, the inhibition of Ras-PI3K interaction has not been investigated previously.

[0009] Understanding the mechanism of Ras activation has generally been limited by the use of isolated domains to structurally characterise Ras-effector interactions. A recent crystal structure of PI3Kγ (Walker et al., 1999) showed that the Ras binding domain (RBD) of the kinase packs against the catalytic domain. However, no cocrystallisation of PI3K and Ras has been available in the art.

SUMMARY OF THE INVENTION

[0010] We have shown that Ras forms a transient complex with PI3Kγ and activates it in vitro and in vivo. To characterise the PI3K interaction with Ras, we have trapped a Ras.PI3Kγ complex and determined its structure by X-ray crystallography. This structure of Ras in complex with PI3Kγ shows interactions that are unique to PI3Ks, and is a good model for the interaction of PI3Kα with Ras. The conformational changes that take place in PI3Kγ upon Ras binding suggest that an allosteric mechanism, in addition to membrane recruitment, may be important in the Ras-mediated activation of this class of effectors. Ras activation of PI3Kγ is synergistic with Gβγ stimulation. The activation of PI3Kγ by both Ras and by Gβγ is probably necessary for the pivotal role of PI3Kγ in fMLP-dependent neutrophil activation.

[0011] The present invention thus provides a crystal comprising PI3K and Ras.

[0012] In a further aspect, the present invention provides a crystal structure for a complex comprising PI3K and Ras. The structure of this crystal has been determined and is set forth in Table 2.

[0013] Optionally, the crystal according to the invention may comprise one or more molecules which bind to Ras and/or PI3K, or otherwise cocrystallise with the Ras/PI3K complex. Such molecules include ligands, which may be candidate pharmaceutical agents intended to modulate the interaction between Ras and PI3K, or other factors, such as P101, which may be involved in the interaction between Ras and PI3K.

[0014] “Ras”, as referred to herein, may be any Ras polypeptide molecule as defined in the art. Particularly preferred is human p21 Ras. The p21 protein is the product of the proto-oncogene ras. Three isozymes of Ras, Ha-Ras (or H-Ras), N-Ras and Ki-Ras are subject to mutation to produce oncogenic variants. The polypeptide used in the crystal according to the invention may be a wild-type polypeptide or a mutant (oncogenic) polypeptide. The primary structure of Ras proteins is well known in the art and available from a number of sources, including GenBank.

[0015] Crystals according to the invention may be prepared using full-length Ras polypeptides; preferably, however, the effector domain is employed in isolation. Typically, the effector domain comprises residues 1-166 of human H-Ras, or the equivalent thereof.

[0016] “PI3K” may be any PI3K isozyme, of class 1A or 1B. Preferred is PI3Kα or γ. As with Ras, the primary structure of PI3K is known in the art and may be determined from a variety of sources, including GenBank.

[0017] The crystal may comprise the full-length PI3 K, but use of the catalytic subunit of PI3K in isolation, preferably a truncated catalytic subunit of PI13K, is preferred. The catalytic subunit or the truncated catalytic subunit typically includes residues 144 to 1102.

[0018] Crystals may be constructed with wild-type PI3K polypeptide sequences. However, the transient nature of Ras-PI3K binding makes crystallisation of such complexes more difficult. Accordingly, a PI3K mutant which stabilises the Ras/PI3K complex is advantageously employed in order to stabilise the Ras-PI3K interaction and facilitate crystallisation. Advantageously, the mutation is a V223K mutation.

[0019] In a preferred embodiment, the invention provides a crystal having the atomic coordinates set forth in Table 2. It will be understood by those skilled in the art that atomic coordinates may be varied, without affecting significantly the accuracy of models derived therefrom; thus, although the invention provides a very precise definition of a preferred atomic structure, it will be understood that minor variations are envisaged and the claims are intended to encompass such variations. Preferred are variants in which the r.m.s. deviation of the x, y and z co-ordinates for all atoms other than hydrogen is less than 2.5 Å (preferably less than 2 Å, advantageously less than 1 Å, and more preferably less than 0.5 Å or less than 0.1 Å) compared with the coordinates given in Table 2.

[0020] The crystals provided in accordance with the present invention may be used to develop models useful for drug design and in silico screening of candidate molecules.

[0021] Models and/or atomic coordinates are advantageously stored on computer-readable media, such as magnetic or optical media and random-access or read-only memory, including tapes, diskettes, hard disks, CD-ROMs and DVDs, flash memory cards or chips, severs and the internet. The computer capable of reading the medium according to the invention may be any suitable computer, such as a Windows®, Macintosh®, LINUX® or UNIX®-based system. The invention accordingly provides a computer-readable medium having stored thereon a model of PI3K/Ras interaction.

[0022] Models of PI3K/Ras interaction may be used to design or screen for drugs capable of modulating this interaction. Such drugs may be capable of or designed to alleviate the resistance to apoptosis, cytoskeletal rearrangement and anoilds conferred through PI3K activation by Ras. Methods for screening and designing drugs based on a crystal structure-derived model of a target are known in the art and described in more detail below. The invention extends to both operator-controlled modelling and automated modelling techniques based on a PI3K/Ras crystal structure-derived target.

[0023] Modelling may be carried out, in particular, on the regions of the target complex which are known to be required for PI3K-Ras interaction. As shown herein, the β-2 strand of Ras and the Rβ2 strand of PI3K are essential in the interaction of these two molecules. Hence, the model according to the invention advantageously comprises the β-2 strand of Ras and/or the Rβ2 strand of PI3K.

[0024] PI3K is shown herein to effect a unique interaction, amongst polypeptides activated by Ras, with both the switch I and the switch II region of Ras. Accordingly, modelling is advantageously carried out to include the interaction of PI3K with both switch I and switch II regions.

[0025] Furthermore, the 225-267 loop of PI3K is demonstrated to be essential for Ras-PI3K interaction. In a preferred aspect, therefore, modelling is carried out to include the PI3K 225-267 loop.

[0026] The invention moreover provides ligands capable of influencing Ras/PI3K interaction, which may be designed or selected by the methods according to the invention.

[0027] Ligands according to the invention are useful in the treatment of diseases associated with cell proliferation and transformation; the invention accordingly provides the use of a ligand as described above in the manufacture of a medicament to treat and/or prevent disease in a mammal, and a method for treating and/or preventing disease in a mammal comprising administering such ligands.

BRIEF DESCRIPTION OF DRAWINGS

[0028]
FIG. 1: (A) In vitro activation of PI3Kγ by H-Ras.GTP. The levels of [32P]-labelled phosphoinositides were measured and data for [32P]-PtdIns(3)P, [32P]-PtdIns(3,4)P2 and PtdIns(3,4,5)P3 are shown. The DASAA PI3Kγ mutant contains the T232D, K251A, K254S, K255A, and K256A mutations. The data are representative of three experiments and were normalised by the amount of PI3Kγ used in the assay.

[0029] (B) In vivo activation of the p110γ/p101 heterodimer by H-Ras.GTP. COS-7 cells were transfected with expression vectors as indicated. Data were collected as above, and are representative of three experiments. (C) G12V H-Ras activation of the wild type and DASAA mutant p110γ in the absence of p101 (D) Synergistic activation of p110γ/p101 heterodimer with Gβγ and G12V H-Ras.

[0030]
FIG. 2: (A) Solution binding of PI3Kγ RBD mutants to N-Ras.mant-GMPPNP. All mutants are in the 144-1102 construct. Titration of some of the mutants was limited by reduced mutant solubility. All error bars represent the standard deviation of at least two measurements. Kd values are listed in the adjacent table. For mutants with no detectable binding, the Kd is listed as >50. (B) Transient kinetic measurements of the association and dissociation rates of the PI3Kγ 144-1102 construct to N-Ras.mant-GMPPNP. The pseudo first order association rates were determined at the PI3Kγ concentrations shown. (C) Transient and steady-state measurements of mant-adenine nucleotide binding to PI3K. All data were collected by fluorescence energy transfer from tryptophan to mant. The Kd values were determined by equilibrium titration independently of the kinetic data.

[0031] (D) Steady-state binding of PI3Kγ 114-1102 to full length, unprocessed H-Ras mutants. The data were obtained as in figure A. For comparison, PI3Kγ binding to H-Ras G12V loaded with mant-GDP is shown.

[0032]
FIG. 3: (A) Diagram of interactions between PI3Kγ and Ras. Also shown are the residues that hold the 255-267 loop in place. The RBD is coloured purple, the Ras is coloured orange, and the catalytic domain is yellow. Putative hydrogen bonds are indicated by dashed lines, and possible salt bridges by dotted lines. PI3Kγ residues that can be mutated to eliminate or attenuate binding are coloured red or blue, respectively. Ellipses indicate residues that were mutated to enhance binding. The V223K tighter binding mutant is shown hydrogen bonding to Ras Glu-37. (B) A closer view of the interface between the RBD (purple) and Ras (orange). The switch I and switch II regions of Ras are coloured pale and dark blue, respectively. Residues that were mutated or that form interactions between the two proteins are labelled. Boxes around residue labels denote mutations that abolish binding, and ellipses indicate mutations that enhance binding. The 255-267 loop that becomes ordered on binding is coloured dark green. The GMPPNP and Mg2+ in Ras are rendered in gray. (C) Solvent-accessible surface of the Ras.PI3Kγ complex. The Ras (orange) and four domains of the PI3Kγ, comprising the RBD purple), C2 domain (cyan), helical domain (green) and N and C-terminal lobes of the catalytic domain (red and yellow) are shown. The N-terminal linker is rendered in white. (D) Ribbon diagram of the Ras.PI3Kγ complex. The colour scheme is the same as the previous panel. The location of the γ phosphate of ATP/PI3Kγ structure is marked with a large gray sphere. This location roughly corresponds to the phosphoinositide headgroup binding site.

[0033]
FIG. 4: (A) Stereo view of the PI3Kγ RBD.Ras complex. The molecules are coloured as in FIG. 3. Lines are traced from the centroid of the RBD through the Cα of Thr-232, then to the centroid of Ras bound to Raf (red sphere and dotted line), RalGDS (yellow sphere and dashed line), and PI3Kγ (cyan sphere and solid line). (B) The Rap1A.RafRBD complex (PDB:1gua). (C) The Ras.RalGDS RBD complex (PDB:11fd). The orientation of the Ras in this complex is more similar to that of Ras in the PI3Kγ complex than that of Rap1A in the RafRBD complex.

[0034]
FIG. 5: (A) Overview of the conformational changes in the Ras.PI3Kγ structure. The structure of the enzyme bound to ATP is traced through the α carbons as a black dotted line. The structure of the Ras.PI3Kγ complex is traced in solid lines and the domains are coloured as in FIG. 3. A gray sphere marks the location of the γ-phosphate of ATP in the structure of the enzyme in the absence of Ras. This would presumably be adjacent to the phospholipid headgroup binding site. (B) A view of the conformational changes in the catalytic domain. The catalytic domains from free PI3K and kinase complexed with Ras were superimposed on the N-terminal lobe of the catalytic domain. The domain from the isolated PI3Kγ is traced as a dashed black line, and the C-α trace of the PI3K catalytic domain is displayed in solid lines.

[0035]
FIG. 6: A model of the Ras.PI3Kγ complex at a putative membrane surface. All regions not visible in the structure are drawn as dashed lines. Lys-973 marks the substrate-binding loop. The 20-residue C-terminal tail of Ras was arbitrarily modelled to illustrate that this peptide could easily span the gap between the RBD-bound Ras and the putative membrane surface. The location of the farnesyl group is indicated schematically. Potential membrane-interacting residues at the tips of the catalytic domain loops are labelled.

[0036]
FIG. 7 shows results of experiments showing inhibition of H-Ras G12V signalling by RBD-Ras Tail chimeras. Transfection of the Raf-1 RBD linked to an H-Ras tail reduces the level of oncogenic H-Ras G12V signalling (as measured by a luciferase assay). The Raf-1 RBD linked to a mutant H-Ras tail that casnnot ge lipid modified or to N- or K-Ras tails is incapable of inhibiting the H-Ras G12V signalling to the same extent.

DETAILED DESCRIPTION OF THE INVENTION

[0037] In one aspect of the present invention, there is provided a crystal comprising Ras and PI3K.

[0038] As used herein, the term “crystal” means a structure (such as a three dimensional (3D) solid aggregate) in which the plane faces intersect at definite angles and in which there is a regular structure (such as internal structure) of the constituent chemical species. Thus, the term “crystal” can include any one of: a solid physical crystal form such as an experimentally prepared crystal, a 3D model based on the crystal structure, a representation thereof such as a schematic representation thereof or a diagrammatic representation thereof, a data set thereof for a computer.

[0039] The mammalian ras gene family consists of the harvey and kirsten ras genes (c-Hras1 and c-Kras2), an inactive pseudogene of each (c-Hras2 and c-Kras1) and the N-ras gene. They differ significantly only in the C-terminal 40 amino acids. These ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins involved in the normal control of cell growth. Mutations which change amino acid residues 12, 13 or 61 activate the potential of Ras to transform cultured cells and are implicated in a variety of human tumours. The N-ras gene specifies two main transcripts of 2 Kb and 4.3 Kb. The difference between the two transcripts is a simple extension through the termination site of the 2 Kb transcript. The N-ras gene consists of seven exons (-I, I, II, III, IV, V, VI). The smaller 2 Kb transcript contains the VIa exon, and the larger 4.3 Kb. transcript contains the VIb exon which is just a longer form of the VIa exon. Both transcripts encode identical proteins as they differ only the 3′ untranslated region. The sequence of human N-Ras is available on GenBank under accession no. NM—002524, gi 6006027.

[0040] c-Ha-ras1 is the normal progenitor of the transforming gene found in several human tumour cell lines (T24 bladder carcinoma; EJ bladder carcinoma; Hs242 lung carcinoma; SK2 melanoma; and HS578T mammary carcinosarcoma). The only difference within the coding exons of the c-Ha-ras1 proto-oncogene and the oncogene of the T24 and EJ cell lines is a ‘g’ to ‘t’ transversion within codon 12 that results in the substitution of valine for glycine at this position in the p21 protein encoded by c-Ha-ras1. The mutation responsible for transforming ability of the p21 protein in the SK2 and Hs242 cell lines is an ‘a’ to ‘t’ transversion within codon 61 that results in the substitution of leucine for glutamine at this position. The mutation responsible for transforming ability of the p21 protein in the HS578T cell line is a ‘g’ to ‘a’ transition within codon 12 that results in the substitution of Aspartic acid for glycine at this position. A region of repeated DNA consisting of the 28 bp consensus sequence ‘cactcccccttctctccaggggacgcca’ begins at position 4755. The repeat occurs 29 times in the plasmid used for this sequence but may occur more times in the native DNA. This region is known to be unessential for transforming activity. The sequence of H-Ras is available on GenBank, Accession No. J00277, gi 190890.

[0041] The sequence of human K-Ras is available under accession no. M54968, gi 1815608.

[0042] The sequence of PI3K is available in GenBank under accession no Y11312, gi 2808446; PI3Kγ is available under Accession no. P48736.

[0043] In a preferred embodiment of this aspect of the invention, the crystal comprises the effector domain of Ras and the catalytic subunit of PI3K, isolated form the remainder of the full-length polypeptides. The effector domain of Ras comprises residues 1-166 of human H-Ras, or the equivalent thereof in other ras polypeptides. The catalytic subunit of PI3K comprises residues 144 to 1102. Advantageously, it contains a V223K mutation.

[0044] In a highly preferred embodiment of this aspect of the invention, the crystal has the structural coordinates as shown in Table 2.

[0045] As used herein, the term “structural co-ordinates” refer to a set of values which define the position of one or more amino acid residues with reference to a system of axes.

[0046] The present invention also provides a crystal structure of a PI3K/Ras complex. The structure of the crystal may be solved by any known method, for example by X-ray diffraction followed by multiple anomalous dispersion (MAD).

[0047] The crystal structure of a PI3K/Ras complex of the present invention provides information about the overall structure of each constituent thereof and about the particular elements of secondary structure for each constituent which are involved in complex formation. In this respect, the crystal structure indicates that the regions which are important in the interaction include residues 25-41 and 60-74 of Ras and residues 220-267 of PI3K. This includes the switch I and switch II regions of Ras.

[0048] As used herein, the term “α-helix” means a helical or spiral configuration of a polypeptide chain in which successive turns of the helix are held together by hydrogen bonds between the amide (peptide) links, the carbonyl group of any given residue being hydrogen-bonded to the imino group of the third residue behind it in the chain. This is the case for all of the carbonyl and amide groups of the peptide bonds of the main chain. Typically, the α-helix has 3.6 residues per turn and the translation or pitch along the helical axis is 1.5 Å per residue and 5.4 Å per turn. The helix may be left- or right-handed, the latter being much more common. The α-helix is one of the two basic elements of the secondary structure adopted by the polypeptide chain within the hydrophobic core of a globular protein. The other basic element is the β strand.

[0049] β strands are usually from 5 to 10 residues long and are in an almost fully extended conformation with φ, Ψ angles within the broad structurally allowed region in the upper left quadrant of the Ramachandran plot. These β strands are aligned adjacent to each other such that hydrogen bonds can form between C'O groups of one β strand and NH groups on an adjacent β strand and vice versa. Parallel or antiparallel β sheets may be formed from several such β strands which are “pleated” with Cα atoms successively a little above and below the plane of the β sheet. The side chains follow this pattern such that within a β strand they also point alternatively above and below the β sheet.

[0050] By using known modelling techniques, the crystal structure of the present invention can be used to produce a model for at least part of the Ras effector domain and/or at least part of the PI3K catalytic subunit.

[0051] As used herein, the term “modelling” includes the quantitative and qualitative analysis of molecular structure and/or function based on atomic structural information and interaction models. The term “modelling” includes conventional numeric-based molecular dynamic and energy minimisation models, interactive computer graphic models, modified molecular mechanics models, distance geometry and other structure-based constraint models.

[0052] The crystal structure of the present invention can be used to generate a structural model such as a three dimensional (3D) structural model (or a representation thereof). Alternatively, the crystal structure may be used to generate a computer model for the structure.

[0053] Molecular modelling techniques can be applied to the atomic co-ordinates of the PI3K/Ras complex to derive a range of 3D models and to investigate the structure of ligand binding sites. A variety of molecular modelling methods are available to the skilled person for use according to the invention [e.g Rational drug design: novel methodology and practical applications, ACS Symposium Series vol. 719 (Parrill & Reddy eds., 1991].

[0054] At the simplest level, visual inspection of a computer model of the PI3K/Ras complex can be used, in association with manual docking of models of functional groups into its binding pockets.

[0055] Software for implementing molecular modelling techniques may also be used. Suitable software and algorithms are generally available, and examples are described below.

[0056] Modelling may include one or more steps of energy minimisation with standard molecular mechanics force fields, such as those used in CHARMM and AMBER (see below).

[0057] These molecular modelling techniques allow the construction of structural models that can be used for in silico drug design and modelling.

[0058] In another aspect of the present invention, the above-mentioned models may be used to screen for or design ligands which are capable of binding the PI3K/Ras complex and/or which are capable of modulating the ability of PI3K and Ras to form a functional complex.

[0059] The screen may employ a solid 3D screening system or a computational screening system. Using these systems, test compounds may be screened to find those which interact spatially and preferentially with PI3K and/or Ras, through either computational or manual docking.

[0060] The molecular modelling steps used in the methods of the invention may use the atomic co-ordinates of a PI3K/Ras complex, and models derived therefrom, to determine binding surfaces. This preferably reveals van der Waals contacts, electrostatic interactions, and/or hydrogen bonding opportunities.

[0061] These binding surfaces will typically be used by grid-based techniques (see below) to map favourable interaction positions for functional groups. This preferably reveals positions in the PI3K/Ras complex for interactions such as, but not limited to, those with protons, hydroxyl groups, amine groups, hydrophobic groups (e.g. methyl, ethyl, benzyl) and/or divalent cations.

[0062] Once functional groups or small molecule fragments which can interact with specific sites in the binding surface of the PI3K/Ras complex have been identified, they can be linked in a single compound using either bridging fragments with the correct size and geometry or frameworks which can support the functional groups at favourable orientations, thereby providing a test compound according to the invention. Whilst linking of functional groups in this way can be done manually, perhaps with the help of software such as QUANTA or SYBYL, the following software may be used for assistance: HOOK [Molecular Simulations, Inc], which links multiple functional groups with molecular templates taken from a database, and/or CAVEAT [Lauri & Bartlett (1994) Comp. Aided Mol. Design 8:51-66], which designs linking units to constrain acyclic molecules.

[0063] Other computer-based approaches to de novo compound design that can be used with the PI3K/Ras atomic co-ordinates include LUDI [Böhm (1992) J. Comp. Aided Molec. Design 6:61-78; Molecular Simulations Inc], SPROUT [http://chem.leeds.ac.uk/ICAMS/SPROUT.html] and LEAPFROG [Tripos Inc].

[0064] A pharmacophore of PI3K and/or Ras can be defined i.e. a collection of chemical features and 3D constraints that expresses specific characteristics responsible for biological activity. The pharmacophore preferably includes surface-accessible features, more preferably including hydrogen bond donors and acceptors, charged/ionisable groups, and/or hydrophobic patches. These may be weighted depending on their relative importance in conferring activity [Computer-Assisted Lead Finding and Optimization (eds. Testra & Folkers, 1997].

[0065] Pharmacophores can be determined using software such as CATALYST (including HypoGen or HipHop) [Molecular Simulations, Inc], CERIUS2, or constructed by hand from a known conformation of a lead compound. The pharmacophore can be used to screen in silico compound libraries, using a program such as CATALYST [Molecular Simulations, Inc].

[0066] Suitable in silico libraries include the Available Chemical Directory (MDL Inc), the Derwent World Drug Index (WDI), BioByteMasterFile, the National Cancer Institute database (NCI), and the Maybridge catalog.

[0067] Compounds in these in silico libraries can also be screened for their ability to interact with the PI3K/Ras complex by using their respective atomic co-ordinates in automated docking algorithms.

[0068] Suitable docking algorithms are described below.

[0069] Docking algorithms can also be used to verify interactions with ligands designed de novo.

[0070] As used herein, the term “test compound” means a compound which may be tested for its capacity to interact with PI3K and/or Ras and/or to modulate the ability of PI3K and Ras to form a functional complex, i.e. a complex which is capable of resulting in the activation of PI3K. The test compound may be designed or obtained from a library of compounds which may comprise peptides, as well as other compounds, such as small organic molecules and particularly new lead compounds. By way of example, the test compound may be a natural substance, a biological macromolecule, or an extract made from biological materials such as bacteria, fungi, or animal (particularly mammalian) cells or tissues, an organic or an inorganic molecule, a synthetic test compound, a semi-synthetic test compound, a structural or functional mimetic, a peptide, a peptidomimetics, a derivatised test compound, a peptide cleaved from a whole protein, or a peptides synthesised synthetically (such as, by way of example, either using a peptide synthesiser or by recombinant techniques or combinations thereof, a recombinant test compound, a natural or a non-natural test compound, a fusion protein or equivalent thereof and mutants, derivatives or combinations thereof.

[0071] Thus, the structural information from the crystal structure of the present invention is useful in the design of potential ligands capable of interacting with the PI3K/Ras complex and/or capable of modulating the ability of PI3K and Ras to form a functional complex, and the models of the present invention are useful to examine the effect such a ligand is likely to have on the structure and/or function of Ras and for PI3K. The present invention also relates to a ligand identified using such methods.

[0072] As used herein, the term “ligand” refers to a test compound capable of binding to Ras and/or PI3K and/or the ras/PI3K complex. Preferably the ligand modulates the interaction between Ras and PI3K.

[0073] The ligands may be natural or synthetic. The term “ligand” also refers to a chemically modified ligand.

[0074] In one aspect, the identified ligand may act as a ligand model (for example, a template) for the development of other compounds.

[0075] As described above, the β-2 strand of Ras and the Rβ2 strand of PI3K are important to the interaction between PI3K and Ras. Advantageously, therefore, test compounds bind to or modulate the interaction of the β-2 strand of Ras and the Rβ2 strand of PI3K.

[0076] Test compounds and ligands which are identified with the crystal of the present invention can be screened in assays such as are well known in the art. Screening can be, for example in vitro, in cell culture, and/or in vivo. Biological screening assays preferably centre on activity-based response models, binding assays (which measure how well a compound binds to Ras and/or PI3K and/or a complex thereof), and bacterial, yeast and animal cell lines (which measure the biological effect of a compound in a cell). The assays can be automated for high capacity-high throughput screening (HTS) in which large numbers of compounds can be tested to identify compounds with the desired activity. The biological assay, may also be an assay for ligand binding activity a compound that selectively binds to Ras and/or PI3K and/or a complex thereof.

[0077] The ligands may be peptide ligands. Preferred peptide ligands are derived from PI3Kγ 220-270 or Ras regions 25-41 or 60-73.

[0078] Advantageously, the peptide ligands are provided in such a manner that the concentration thereof is selectively increased in the region of the plasma membrane, where PI3K is known to be significantly concentrated due to its intrinsic affinity for lipid membranes. For example, peptide ligands may incorporate a flexible membrane anchor, such that they are flexibly tethered to the membrane surface. Such a membrane anchor may be, for example, CAAX (C=Cys, A=aliphatic amino acid, X=any amino acid). This allows the inhibitory peptide to exploit the same membrane-concentrating effect as full-length PI3K, and allow peptides having even low affinities to bind Ras at the membrane. The use of CAAX for membrane localisation is known in the art and described, for example, in Kato et al., PNAS (1992) 89:6403-6407.

[0079] This embodiment is described in further detail in Example 3 below.

[0080] Peptides may be delivered to cells by any known means, including delivery by cellular localisation peptides such as the protein transduction domains of HIV Tat, HSV VP22 or Drosophila Antannapedia, as reviewed by Schwarze et al in Trends in Cell Biol. (2000) 10:290-295.

[0081] The ligand of the present invention may be used in a pharmaceutical composition, optionally together with a pharmaceutically acceptable carrier, diluent or excipient (including combinations thereof).

[0082] The pharmaceutical compositions may be for human or animal usage in human and veterinary medicine and will typically comprise any one or more of a pharmaceutically acceptable diluent, carrier, or excipient. Acceptable carriers or diluents for therapeutic use are well known in the pharmaceutical art, and are described, for example, in Remington's Pharmaceutical Sciences, Mack Publishing Co. (A. R. Gennaro edit. 1985). The choice of pharmaceutical carrier, excipient or diluent can be selected with regard to the intended route of administration and standard pharmaceutical practice. The pharmaceutical., compositions may comprise as—or in addition to—the carrier, excipient or diluent any suitable binder(s), lubricant(s), suspending agent(s), coating agent(s), solubilising agent(s).

[0083] Preservatives, stabilisers, dyes and even flavouring agents may be provided in the pharmaceutical composition. Examples of preservatives include sodium benzoate, sorbic acid and esters of p-hydroxybenzoic acid. Antioxidants and suspending agents may be also used.

[0084] There may be different composition/formulation requirements dependent on the different delivery systems. By way of example, the pharmaceutical composition of the present invention may be formulated to be delivered using a mini-pump or by a mucosal route, for example, as a nasal spray or aerosol for inhalation or ingestable solution, or parenterally in which the composition is formulated by an injectable form, for delivery, by, for example, an intravenous, intramuscular or subcutaneous route. Alternatively, the formulation may be designed to be delivered by both routes.

[0085] Where the pharmaceutical composition is to be delivered mucosally through the gastrointestinal mucosa, it should be able to remain stable during transit though the gastrointestinal tract; for example, it should be resistant to proteolytic degradation, stable at acid pH and resistant to the detergent effects of bile.

[0086] Where appropriate, the pharmaceutical compositions can be administered by inhalation, in the form of a suppository or pessary, topically in the form of a lotion, solution, cream, ointment or dusting powder, by use of a skin patch, orally in the form of tablets containing excipients such as starch or lactose or chalk, or in capsules or ovules either alone or in admixture with excipients, or in the form of elixirs, solutions or suspensions containing flavouring or colouring agents, or they can be injected parenterally, for example intravenously, intramuscularly or subcutaneously. For parenteral administration, the compositions may be best used in the form of a sterile aqueous solution which may contain other substances, for example enough salts or monosaccharides to make the solution isotonic with blood. For buccal or sublingual administration the compositions may be administered in the form of tablets or lozenges which can be formulated in a conventional manner.

[0087] The invention further provides a method of preventing and/or treating disease in a mammal, the method comprising administering to a mammal a ligand or pharmaceutical composition of the present invention.

[0088] Typically, a physician will determine the actual dosage which will be most suitable for an individual subject and it will vary with the age, weight and response of the particular patient and severity of the condition. The dosages below are exemplary of the average case. There can, of course, be individual instances where higher or lower dosage ranges are merited.

[0089] The compositions (or component parts thereof) of the present invention may be administered orally. In addition or in the alternative the compositions (or component parts thereof) of the present invention may be administered by direct injection. In addition or in the alternative the compositions (or component parts thereof) of the present invention may be administered topically. In addition or in the alternative the compositions (or component parts thereof) of the present invention may be administered by inhalation. In addition or in the alternative the compositions (or component parts thereof) of the present invention may also be administered by one or more of: parenteral, mucosal, intramuscular, intravenous, subcutaneous, intraocular or transdermal administration means, and are formulated for such administration.

[0090] By way of further example, the pharmaceutical composition of the present invention may be administered in accordance with a regimen of 1 to 10 times, per day, such as once or twice per day. The specific dose level and frequency of dosage for any particular patient may be varied and will depend upon a variety of factors including the activity of the specific compound employed, the metabolic stability and length of action of that compound, the age, body weight, general health, sex, diet, mode and time of administration, rate of excretion, drug combination, the severity of the particular condition, and the host undergoing therapy.

[0091] The term “administered” also includes but is not limited to delivery by a mucosal route, for example, as a nasal spray or aerosol for inhalation or as an ingestable solution; a parenteral route where delivery is by an injectable form, such as, for example, an intravenous, intramuscular or subcutaneous route.

[0092] Hence, the pharmaceutical composition of the present invention may be administered by one or more of the following routes: oral administration, injection (such as direct injection), topical, inhalation, parenteral administration, mucosal administration, intramuscular administration, intravenous administration, subcutaneous administration, intraocular administration or transdermal administration.

[0093] Production of the Crystal

[0094] The crystals of the present invention may be prepared by expressing a nucleotide sequence encoding Ras and PI3K, by the use of a suitable host cell, and then crystahising the purified protein(s).

[0095] As used herein, the term “nucleotide sequence” refers to nucleotide sequences, oligonucleotide sequences, polynucleotide sequences and variants, homologues, fragments and derivatives thereof (such as portions thereof) which comprise the nucleotide sequences encoding Ras and PI3K amino acid sequences. The nucleotide sequence may be DNA or RNA of genomic or synthetic or recombinant origin which may be double-stranded or single-stranded whether representing the sense or antisense strand or combinations thereof. Preferably, the term nucleotide sequence is prepared by use of recombinant DNA techniques (e.g. recombinant DNA). The nucleotide sequence may include within them synthetic or modified nucleotides. A number of different types of modification to oligonucleotides are known in the art. These include methylphosphonate and phosphorothioate backbones, addition of acridine or polylysine chains at the 3′ and/or 5′ ends of the molecule. For the purposes of the present invention, it is to be understood that the nucleotide sequences described herein may be modified by any method available in the art. Such modifications may be carried out in order to enhance the in vitro activity or life span of nucleotide sequences of the invention.

[0096] To produce a Ras/PI3K complex, it is preferable for the individual polypeptides to be expressed separately and mixed for crystallisation, due to the very fast off rate of the complex.

[0097] The sequences expressed may be wild-type or mutant sequences. The term “wild type” refers to the phenotype that is characteristic of most of the members of a species occurring naturally and which contrasts with the phenotype of a mutant species.

[0098] The term “mutant” refers to any organism that has undergone mutation or that carries a mutant gene that is expressed in the phenotype of that organism. A mutation may arise due to a substitution of one nucleotide for another or from a deletion of a nucleotide or an insertion of a nucleotide relative to a referenced wild type sequence. These single nucleotide variations are sometimes referred to as single nucleotide polymorphisms (SNPs). Some SNPs may occur in protein-coding sequences, in which case, one of the polymorphic forms may give rise to the expression of a defective or other variant protein and, potentially, a genetic disease. Other SNPs may occur in noncoding regions. Some of these polymorphisms may also result in defective protein expression (e.g., as a result of defective splicing). Other SNPs may have no phenotypic effects.

[0099] As used herein, the term “mutant” refers to polypeptide comprising any one or more changes in the sequence (the structural co-ordinates) and of the amino acid residues in Ras and/or PI3K.

[0100] As used herein, the term “variant” refers to Ras and/or PI3K or a portion thereof which may have deletions, insertions or substitutions of amino acid residues as long as the binding specificity of the molecules for each other in a Ras/PI3K complex is retained to the extent desired. In this regard, deliberate amino acid substitutions may be made on the basis of similarity in polarity, charge, solubility, hydrophobicity, hydrophilicity, and/or the amphipathic nature of the residues.

[0101] A wide variety of host cells can be employed for expression of the nucleotide sequences encoding the Ras and/or PI3K proteins of the present invention. These cells may be both prokaryotic and eukaryotic host cells. Suitable host cells include bacteria such as E. coli, yeast, filamentous fungi, insect cells, mammalian cells, typically immortalised, e.g., mouse, CHO, human and monkey cell lines and derivatives thereof. Preferred host cells are able to process the expression products to produce an appropriate mature polypeptide(s). Processing includes but is not limited to glycosylation, ubiquitination, disulphide bond formation and general post-translational modification.

[0102] The proteins comprising Ras and/or PI3K, produced by a host recombinant cell, may be secreted or may be contained intracellularly depending on the nucleotide sequence and/or the vector used. As will be understood by those of skill in the art, expression vectors containing the Ras and/or PI3K encoding nucleotide sequences can be designed with signal sequences which direct secretion Ras and/or PI3K coding sequences through a particular prokaryotic or eukaryotic cell membrane.

[0103] Other recombinant constructions may join the Ras and/or PI3K encoding sequence to nucleotide sequence encoding a polypeptide domain which will facilitate purification of soluble proteins (Kroll D J et al (1993) DNA Cell Biol 12:441-53). Such purification facilitating domains include, but are not limited to, metal chelating peptides such as histidine-tryptophan modules that allow purification on immobilised metals (Porath J (1992) Protein Expr Purif 3-0.26328 1), protein A domains that allow purification on immobilised immunoglobulin, and the domain utilised in the FLAGS extension/affinity purification system (Immunex Corp, Seattle, Wash.). The inclusion of a cleavable linker sequence such as Factor XA or enterokinase (Invitrogen, San Diego, Calif.) between the purification domain and the AR and PR is useful to facilitate purification.

[0104] Ras and/or PI3K may also be produced as fusion proteins, for example to aid in extraction and purification. Examples of fusion protein partners include glutathione-S-transferase (GST), 6×His, GAL4 (DNA binding and/or transcriptional activation domains) and β-galactosidase. It may also be convenient to include a proteolytic cleavage site between the fusion protein partner and the protein sequence of interest to allow removal of fusion protein sequences.

[0105] Preferably the fusion protein will not hinder the complexing capacity of Ras and/or PI3K.

[0106] After expression, the proteins may be purified and/or concentrated, for example by immobilised metal affinity chromatography, ion-exchange chromatography, and/or gel filtration. For crystals of the Ras/PI3K complex, Ras and PI3K fragments may be purified and allowed to dimerise in solution.

[0107] The protein(s) may be crystallised using any of the known techniques. Usually, in a crystallisation process, a crystallisation buffer is prepared with a lower concentration of a precipitating agent necessary for crystal formation. For crystal formation, the concentration of the precipitating agent has to be increased, by addition of precipitating agent or by diffusion of the precipitating agent between the crystallisation buffer and a reservoir buffer. Diffusion may be achieved by known techniques such as the “hanging drop” or the “sitting drop” method. In these methods, a drop of crystallisation buffer containing the protein(s) is hanging above or sitting beside a much larger pool of reservoir buffer. Alternatively, the balancing of the precipitating agent can be achieved through a semi-permeable membrane that separates the crystallisation buffer and prevents dilution of the protein into the reservoir buffer.

[0108] Generating the Crystal Structure

[0109] Once the crystals have been obtained, the structure may be solved by known Xray diffraction techniques. Many techniques use chemically modified crystals, such as those modified by heavy atom derivatization. In practice, a crystal is soaked in a solution containing heavy metal atom salts, or organometallic compounds, e.g., lead chloride, gold thiomalate, thimerosal or uranyl acetate, which can diffuse through the crystal and bind to the surface of the protein. The location(s) of the bound heavy metal atom(s) can the n be determined by X-ray diffraction analysis of the soaked crystal. The patterns obtained on diffraction of a monochromatic beam of X-rays by the atoms (scattering centers) of the crystal can be solved by mathematical equations to give mathematical coordinates. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density maps are used to establish the positions of the individual atoms within the unit cell of the crystal. Blundel, T. L. and N. L. Johnson, Protein Crystallography, Academic Press (1976).

[0110] Those of skill in the art understand that a set of structural coordinates determined by X-ray crystallography is not without standard error. For the purpose of this invention, any set of structure coordinates for Ras:PI3K complexes that have a root mean square deviation of protein backbone atoms of less than 0.75 Å when superimposed (using backbone atoms) on the structure coordinates listed in Table 3 shall be considered identical.

[0111] Modelling

[0112] The three dimensional structure of a new crystal may be modelled using molecular replacement. The term “molecular replacement” refers to a method that involves generating a preliminary model of a molecule or complex whose structure coordinates are unknown, by orienting and positioning a molecule whose structure coordinates are known within the unit cell of the unknown crystal, so as best to account for the observed diffraction pattern of the unknown crystal. Phases can then be calculated from this model and combined with the observed amplitudes to give an approximate Fourier synthesis of the structure whose coordinates are unknown. This, in turn, can be subject to any of the several forms of refinement to provide a final, accurate structure of the unknown crystal. Lattman, E., “Use of the Rotation and Translation Functions”, in Methods in Enzymology, 115, pp. 55-77 (1985); M. G. Rossmann, ed., “The Molecular Replacement Method”, Int. Sci. Rev. Ser., No. 13, Gordon & Breach, N.Y., (1972).

[0113] Other molecular modelling techniques may also be employed in accordance with this invention. See, e.g., Cohen, N. C. et al., “Molecular Modelling Software and Methods for Medicinal Chemistry”, J. Med. Chem., 33, pp. 883-894 (1990). See also, Navia, M. A. and M. A. Murcko, “The Use of Structural Information in Drug Design”, Current Opinions in Structural Biology, 2, pp. 202-210 (1992).

[0114] Using the structure coordinates of the Ras:PI3K crystal complex provided by this invention, molecular replacement may be used to determine the structure coordinates of a crystalline mutant or homologue of Ras and/or PI3K or of a related protein (such as a Ras variant).

[0115] Ligand Screening

[0116] One skilled in the art may use one of several methods to test compounds for their ability to associate with Ras and/or PI3K. This process may begin by visual inspection of, for example, a target site on the computer screen based on the structure coordinates given in Table 3. Selected test compounds may then be positioned in a variety of orientations, or docked, within an individual target site of Ras and/or PI3K as defined supra. Docking may be accomplished using software such as Quanta and Sybyl, followed by energy minimisation and molecular dynamics with standard molecular mechanics forcefields, such as CHARMM and AMBER.

[0117] Specialised computer programs may also assist in the process of selecting potential ligands. These include:

[0118] 1. GRID (Goodford, P. J., “A Computational Procedure for Determining Energetically Favorable Binding Sites on Biologically Important Macromolecules”, J. Med. Chem., 28, pp. 849-857 (1985)). GRID is available from Oxford University, Oxford, UK.

[0119] 2. MCSS (Miranker, A. and M. Karplus, “Functionality Maps of Binding Sites: A Multiple Copy Simultaneous Search Method.” Proteins: Structure. Function and Genetics, 11, pp. 29-34 (1991)). MCSS is available from Molecular Simulations, Burlington, Mass.

[0120] 3. AUTODOCK (Goodsell, D. S. and A. J. Olsen, “Automated Docking of Substrates to Proteins by Simulated Annealing”, Proteins: Structure. Function, and Genetics, 8, pp. 195-202 (1990)). AUTODOCK is available from Scripps Research Institute, La Jolla, Calif.

[0121] 4. DOCK (Kuntz, I. D. et al., “A Geometric Approach to Macromolecule-Ligand Interactions”, J. Mol. Biol., 161, pp. 269-288 (1982)). DOCK is available from University of California, San Francisco, Calif.

[0122] Once a ligand has been optimally selected or designed, substitutions may then be made in some of its atoms or side groups in order to improve or modify its binding properties.

[0123] Generally, initial substitutions are conservative, i.e., the replacement group will have approximately the same size, shape, hydrophobicity and charge as the original group. It should, of course, be understood that components known in the art to alter conformation should be avoided. Such substituted chemical compounds may then be analysed for efficiency of fit to Ras and/or PI3K by the same computer methods described above.

EXAMPLES

[0124] The following examples serve to illustrate the present invention, but should not be construed as a limitation thereof. The invention particularly relates to the specific embodiments described in these examples.

[0125] Experimental Procedures

[0126] Protein Cloning and Expression

[0127] For crystallography, equilibrium binding, and kinetic measurements, a construct containing residues 144-1102 of the human PI3Kγ with a C-terminal His6 tag was cloned into pVL1393 (InVitrogen) for baculovirus expression. The human enzyme has 1102 residues, not 1101 as indicated by the GenBank sequence P48736. The error in the database sequence is due to omission of an Ala following Ala-29. To make the RBD mutants, we used a cassette containing a V327A mutation, which encoded a NheI site used for subcloning. This V327A “pseudo wild type” construct has the same affinity for N-Ras as the wild type protein (FIG. 2A). The DASAA PI3Kγ mutant used for the in vitro and in vivo experiments contains the T232D, K251A, K254S, K255A, and K256A mutations in the context of the fall-length pseudo wild type p110γ subunit. For expression in COS-7 cells, the DASAA mutant was subcloned into pcDNA3 with no tags. For in vitro Ras activation studies, the DASAA mutant was subcloned into pVL1393 with a C-terminal His6 tag.

[0128] PI3K constructs in pVL1393 were transfected into Sf9 cells with BaculoGold DNA (Pharmingen). Infected cells were incubated at 27° C. for 48 hrs. Harvested cells were washed in PBS, pelleted, frozen in liquid nitrogen, and stored at −80° C.

[0129] The DNA sequence encoding residues 1- 166 of H. sapiens H-Ras G12V was cloned as a NdeI/BamHI fragment into pET11a (Novagen) and transformed into C41([)E3) cells. For expression, bacteria were grown at 37° C. to an O.D.600 of 0.7, and induced with 100 μM IPTG for 12 hours. Full-length, his-tagged H-Ras mutants (a gift from J. Downward) were grown in a similar manner and induced for 5 hours with 500 μM IPTG.

[0130] In Vitro and in Vivo Activity Measurements

[0131] H-Ras was loaded with GTPγS or GDP by incubation in exchange buffer (50 mM Tris pH 7.5, 40 mM EDTA, 200 mM (NH4)2SO4) with a 20-fold molar excess of the nucleotide. The protein was gel-filtered on a PD-10 column (Pharmacia) and frozen at −80° C.

[0132] In vitro assays were carried out in 10 μL of ice-cold reaction buffer (0.12 M NaCl, 25 mM HEPES pH 7.5, 1 mM EGTA, 1 mM DTT, 1 mg/mL BSA, 1% betaihe (0.02% w/v) and 1% Tween 20) with 1 μM lipid-modified, full length H-Ras loaded with GTPγS or GDP, and 300 ng of p110γ/p101 complex. All assays contained 5 μg neutrophil memnbranes and 5-10 μCi of γ-32P ATP. The reaction was ran for 16 minutes, quenched, and the lipids were extracted, deacylated and quantitated by HPLC as described (Stephens et al., 1991).

[0133] COS-7 cells were transfected with plasmid DNA (5 μg full-length PI3Kγ, 5 μg myc-tagged p101, 5 μg H-Ras G12V, or an unrelated control DNA for a total of 15 μg per transfection in a final volume of 0.5 mL) as described previously (Stephens et al., 1997). After electroporation, the cells were incubated for 48 hours, washed in HEPES-buffered DMEM containing 1 mM NaHCO3 and 0.2% fatty acid-free BSA, and serum-starved for a further 10 hours. The cells were washed with phosphate-free medium and incubated for 60 minutes with 300-500 μCi γ-32P ATP per dish. The cells were harvested and 32P-labeled phospholipids measured as above.

[0134] Protein Purification

[0135] Sf9 cells from 0.9 L of culture were sonicated in buffer (50 mM KH2PO4, 10 mM Tris, pH 8, 0.1 M NaCl, 1 mM MgCl2) containing protease inhibitors (complete EDTA-free tablets, Boehringer Mannheim/Roche). After centrifugation, the supernatant was incubated with Talon resin (Clontech) for an hour. The resin was washed with 100 mL of solution 1 (50 mM KH2PO4 pH 8.0, 20 mM Tris, pH 8, 0.1 M NaCl, 1% betaine, 0.05% Tween 20), 125 mL of solution 2 (50 mM KH2PO4 pH 7.0, 20 mM Tris pH 7.5, 0.1 M NaCl, 1% betaine, 0.05% Tween 20), and 50 mL of solution 3 (20 mM Tris, pH 7.5, 10 mM imidazole, 0.1 M NaCl, 1% betaine, 1% ethylene glycol). Protein was eluted with 30 mL of elution buffer (20 mM KH2PO4, pH 5.6, 0.1 M EDTA, 1% betaine, 1% ethlyene glycol, and 0.02% CHAPS). The protein was loaded onto a HiTrap SP column (Phannacia), washed with 0.1 M NaCl in 20 mM KH2PO4, pH 5.6, 1 mM DTT and eluted with 0.45 M NaCl. The protein was concentrated to 1 mL (Ultrafree-4, 30K cutoff filter, Millipore) and loaded onto a PD-10 colurnn equilibrated in gel filtration buffer (20 mM Tris pH 7.2, 50 mM (NH4)2SO4, 1% betaine, 1% ethylene glycol, 0.02% CHAPS, 5 mM DTT), concentrated to 4-6 mg/mL and snap frozen.

[0136] H-Ras 1-166 was extracted from 1 L of bacterial culture with B-PER reagent (Pierce) and purified by two passages over a HiLoad Q column (Pharmacia) with a salt gradient (0-1 M KCl in 50 mM Tris pH 7.5, 1 mM MgCl2, 5 μM GDP, and 1 mM DTT). The protein was gel filtered on a Superdex 75 column (Pharmacia) in storage buffer (50 mM Tris pH 7.5, 1 mM MgCl2, 5 μM GDP, and 1 mM DTT), concentrated to 20 mg/mL, and snap frozen. Full-length H-Ras mutants were purified as previously described (Rodriguez-Viciana et al., 1997).

[0137] To load the H-Ras with GMPPNP, 200 nmol of protein were mixed with 3 μmol of GMPPNP (Sigma) in 1 mL of Ras loading buffer (50 mM Tris pH 8.5, 1 mM EDTA, 200 mM (NH4)2SO4). The mixture was incubated for 1 hour with alkaline phosphatase (2 μL) (Boehringer Mannheim) and the exchange stopped by the addition of MgCl2 to 50 mM. H-Ras was gel filtered on a Superdex 75 column in 20 mM Tris, pH 7.5, 2 mM MgCl2, and 1 mM DTT. The protein was concentrated to ˜12 mg/mL and snap frozen.

[0138] Anisotropy Titrations

[0139] Mant-nucleotides were synthesised as described previously (Jameson and Eccleston, 1997). N-Ras and H-Ras mutants were loaded with mant-GMPPNP as in (Moore et al., 1993), gel filtered into running buffer (20 mM Tris pH 7.5, 2 mM MgCl2, 1 mM DTT), and frozen at −80° C. The concentration of Ras.mant-GMPPNP was determined by measuring the absorbance of the mant group at 350 nM with ε=5700 M−1 cm−1 (Hiratsuka, 1983). For binding assays, the 144-1102 human PI3Kγ was titrated into a 1 μM solution of fill length, unmodified N-Ras.mant-GMPPNP. Data were collected with SLM 8000 S and ISS PC1 spectrofluorimeters, set up in the T-format and L-format, respectively, with prism polarizers. All measurements were taken at 20° C. with a λex of 366 nm. Both emission PMTs were fitted with 399 nm cutoff filters. Five measurements of each data point were obtained and averaged. Data were fitted to the binding equation.

[0140] Stopped Flow Anisotropy

[0141] A Hi-Tech MX61 instrument (Hi-Tech, Salisbury) set up in the T-format with prism polarizers was used to collect data at 20° C. The mant group was excited at 366 nm and emission monitored through 399 nm cutoff filters. The association kinetics were followed by rapid mixing of PI3Kγ with 1 μM N-Ras.mant-GMPPNP under pseudo first-order conditions (PI3Kγ in large excess). Specifically, equal proportions of N-Ras and PI3Kγ were mixed to a final Ras concentration of 1 μM and final PI3Kγ concentrations of 5 and 10 μM. The dissociation rate was measured by mixing a solution of 1 μM N-Ras.mant-GMPPNP and 5 μM PI3K with 9 μM N-Ras.GMPPNP. Attempts to determine association rates at higher PI3K concentrations were limited by solubility of the protein. Data were fitted to single exponential curves within the Hi-Tech software.

[0142] Steady State and Kinetic Measurements of ATP and ADP Binding

[0143] Equilibrium binding of mant-ATP to PI3K was measured in a SLM 8000 S spectrofluorimeter with λex=280 nm and λex=440 nm. This allowed monitoring of energy transfer from tryptophan in the PI3K to mant-ATP. Mant-ATP was titrated into a 1 μM solution of PI3K in running buffer. Each data point represents the average of data collected for 30 seconds with a 1 second integration time. For data collected in the presence of Ras, the solution also contained 6 μM H-ras.GMPPNP. The data were fitted to the binding equation with Kaleidagraph.

[0144] All kinetic data were collected in a Hi-Tech Na61 instrument set up in the single push mode with λex=280 nm and emission monitored with 399 nm cutoff filters. A solution of PI3K was mixed a solution of mant-ATP such that the final PI3K concentration was 1 μM and the ATP concentrations were 2.5, 5. 7.5, 10, 12.5, and 25 μM. The displacement experiment was carried out by mixing 1 μM PI3K and 2 μM mant-ATP with 50 or 200 μM ATP. Curve fits were carried out with the Hi-Tech software and Kaleidagraph. Equilibrium and kinetic data for mant-ADP were collected by the same methods.

[0145] Crystallography

[0146] H-Ras.GMPPNP and PI3Kγ (V223K in the context of the 144-1102 pseudo wild type construct) were mixed to final concentrations of 170 μM for H-Ras and 29 μM for PI3K. The mixture was incubated for 3 days at 17° C., and then set in hanging drops against a reservoir of 50 mM KH2PO4/K2HPO4 pH 6.3, 4.3% PEG 8000. Crystals were propagated by hair seeding and grew to dimensions of 120 μM×70 μM×50 μM in 10 days. SDS-PAGE analysis of the crystals showed that the PI3Kγ had been completely digested into four fragments (43, 32, 20, and 10 kDa) during the time course of crystallisation. The largest crystals were transferred to cryoprotectant (reservoir with 40% trehalose) in two steps, each lasting thirty seconds, and frozen in a liquid N2 cryostream.

[0147] Data sets were collected at beamlines ID14-2 and ID14-1 at the European Synchotron Radiation Facility in Grenoble at a wavelength of 0.934 Å. The space group was P3121 with cell dimensions of a=b=113.6 Å, c=183.9 Å, α=β=90°, γ=120°, and one complex in the asymmetric unit. The reflections from two crystals were indexed and integrated with MOSFLM (Leslie, 1992), merged, and scaled with SCALA (CCP4, 1994). Molecular replacement was carried out with AmoRe. The initial model consisted of our PI3Kγ structure (PDB:1qmm). A second rotation/translation search with the structure of Ras (Pai et al., 1990) (PDB:5p21) located the Ras molecule. The partial model was rebuilt in O (Jones et al., 1991) and refined with CNS (Brunger et al., 1998). The average B factor is 70 Å2. No residues are in the disallowed regions of the Ramachandran plot. Figures were prepared with MOLSCRIPT (Kraulis, 1991), GRASP (Nicholls et al., 1991), and Raster3D (Merritt and Bacon, 1997).

[0148] In the structure, all residues in the Ras are visible. As in the previous structure of the free PI3Kγ, several loops are not visible in the electron density. These include the RBD-C2 domain linker (residues 323-352), CBR3 in the C2 domain (residues 436-456), the loop between C2β7 and C2β8 (residues 489-497), the activation loop in the catalytic domain (residues 969-980), and residues 1085 to 1102 in the C-terminus. Several loops that were defined in the free PI3K are not visible in the electron density of the complex. These include CBR1 (residues 375-378), and loops between residues 754-760, residues 896-901, and residues 1038-1046. It is possible that some of the disordered loops not visible in the electron density also correspond to sites of proteolytic nicking (see above).

[0149] The N-terminal half of the helical domain (residues 527-620, containing helices hA1 to hB2′) is not present in the structure. Since the Ras of a symmetry-related complex packs in this space, and SDS-PAGE analysis of the crystals showed no full-length PI3Kγ, it appears that this half of the domain was lost to proteolysis during crystallisation.

[0150] The ordering of the 255-267 loop and better side-chain definition at places in the region from 228 to 255 showed that there was a register shift in the fit of the sequence to the electron density in the original structure of PI3K in the absence of Ras.

Example 1

[0151] Ras/PI3K Interaction

[0152] Ras.GTP Directly Activates PI3Kγ

[0153] PI3Ks are able to integrate and amplify signals received from multiple signalling pathways. Tyrosine kinases and Ras synergistically activate PI3Kα (Rodriguez-Viciana et al., 1996b), while tyrosine kinases and the Gβγ subunits of heterotrineric G proteins synergistically activate PI3Kβ (Kurosu et al., 1997). Although binding of Gβγ strongly stimulates PI3Kγ (Stephens et al., 1997; Maier et al., 1999), the functional significance of Ras binding to PI3Kγ and its relationship with Gβγ activation have not been established. To determine the consequences of Ras binding to PI3Kγ, we investigated the effect of full-length, lipid modified, constitutively activated H-Ras (G12V) on PI3Kγ activity in vitro, using isolated neutrophil membranes. Our results indicate that H-Ras.GTP causes a 170-fold increase in the level of PtdIns(3,4)P2 and a 48-fold increase in PtdIns(3,4,5)P3 for the p110γ/p101 heterodimer (FIG. 1A). This activation is strictly dependent on Ras.GTP, and greatly exceeds previously reported stimulation of p110α/p85 heterodimer by Ras (Rodriguez-Viciana et al., 1996b). The p110γ subunit alone is also stimulated by H-Ras.GTP with a 3-fold and a 4-fold increase in the production of PtdIns(3,4)P2 and PtdIns(3,4,5)P3, respectively (FIG. 1A). Based on our structure of a complex of PI3Kγ with Ras (see below) we constructed a p110γ variant in which several residues essential for Ras binding were mutated. This multiple mutant (DASAA) has the same basal activity as the wild type enzyme in vitro, but is not activated by H-Ras.GTP (FIG. 1A). These results demonstrate that H-Ras directly activates PI3Kγ.

[0154] To demonstrate Ras activation of PI3Kγ in vivo, and its relationship to Gβγ stimulation, we transfected COS-7 cells with H-Ras (G12V), full-length p110γ, and p101. As shown in FIG. 1B, H-Ras stimulated the PI3Kγ activity by 4- to 7-fold. The level of activation is similar to the Ras activation of PI3Kα in COS-7 cells (Rodriguez-Viciana et al., 1994). Furthermore, Gβγ and Ras synergistically stimulate PI3Kγ activity (FIG. 1B). As in the in vitro experiments, Ras stimulates PI3Kγ activity in the absence of the p101 subunit (FIG. 1B). This stimulation of PI3Kγ by Ras is considerably greater than previously reported (Rubio et al., 1997) and may be due to differences in the constructs used. We have used a full length p110γ, whereas the previous work used a deletion variant. The previous work also used p110γ in the absence of p101. Our work shows that p101 is not essential for Ras activation, but greatly augments it.

[0155] PI3Kγ is abundant in neutrophils, and is essential for the production of reactive oxygen species (respiratory burst) that have an important role in the inflammatory response of these cells (Hirsch et al., 2000; Li et al., 2000; Sasaki et al., 2000). PI3Kγ activation by N-formyl-methionine-leucine-phenylalanine (fMLP) proceeds through G protein coupled receptors, which activate heterotrimeric G proteins. fMLP stimulation of neutrophils also causes a rapid activation of Ras (Worthen et al., 1994; Coffer et al., 1998). Because Ras activates PI3Kγ, it is possible that Ras and Gβγ synergistically participate in the fMLP-induced, PI3Kγ-dependent respiratory burst in neutrophils.

[0156] PI3Kγ Forms a Transient Complex with Ras.mant-GMPPNP

[0157] We characterised the solution binding of PI3Kγ to Ras by observing changes in the fluorescence anisotropy of full length, unmodified N-Ras.mant-GMPPNP (mant, 2′- (or -3′)-O-(N-methylanthraniloyl)). The Kd for wild type PI3Kγ and N-Ras.mant-GMPPNP is 2.8±0.4 μM. The Kd for wild type H-Ras (3.2±0.5 μM) is nearly identical to the Kd for N-Ras. This dissociation constant is higher than the 160 nM Kd for the Ras.Raf RBD complex (Herrmann et al., 1995; Sydor et al., 1998) and the 1 μM Kd for the Ras.RalGDS RBD complex (Herrmann et al., 1996). It is also approximately ten fold higher than the previously published dissociation constant for PI3Kγ and Ras (Rubio et al., 1999). The discrepancy between our results and those reported previously for p110γ may be due to differences in the constructs and methods used to determine the dissociation constants. The previously published work used pull-down assays with an immobilised GST-PI3Kγ construct.

[0158] Although the solution Kd for the PI3Kγ.Ras complex is high, it would be sufficient for interaction of the two proteins on lipid membranes. A similar situation is apparent for other signalling complexes that are active at membrane surfaces. For example, the estimated affinity of phospholipase Cβ2 (PLCβ2) for the Gβγ subunits in the bulk phase is about 3 μM, yet Gβγ is one of the principal activators of PLCβ2 activity in cells (Runnels and Scarlata, 1998). Because PLCβ and Gβγ subunits have high affinities for membrane, these signalling components become concentrated at lipid membranes. The result of this concentration is that even fairly weak interactions lead to lateral association on the membrane. PI3Kα and PI3Kγ ((Barnett et al., 1995) and L. Stephens, unpublished data) have been shown to strongly bind to phosphoinositide-containing lipid membranes even in the absence of any other protein components. Consequently, the bulk affinities that we measure for soluble Ras translates into a significant interaction with membrane-localised Ras.

[0159] Dynamic studies of PI3Kγ and N-Ras indicate both rapid association and dissociation of the two proteins (FIG. 2B). While the dissociation rate of the complex is similar to that of Ras.Raf RBD, the association rate of PI3Kγ.Ras is an order of magnitude slower (Sydor et at., 1998). The association rate constant of the Ras.PI3K complex (18 s−1) is two orders of magnitude higher than the catalytic turnover rate of PI3Kγ, which is about 0.1 s−1 for PtdIns(3,4,5)P3 (Maier et al., 1999). As with the Ras.Raf complex, the “activating” interaction of PI3Kγ with Ras is limited by the dissociation of the Ras.effector complex and not by the catalytic cycle of the effector enzyme. The transience of the complex ensures that PI3Kγ is not constitutively activated.

Example 2

[0160] Crystallographic Studies

[0161] Structure of a Ras.PI3Kγ Complex

[0162] We reasoned that the transience of the Ras.PI3Kγ complex might be an impediment to the determination of its structure. Using a predicted model of the interaction of PI3Kγ with Ras (Walker et al., 1999), we constructed two tighter-binding PI3K mutants, V223K and E267K, for co-crystallisation with Ras. The Kds for Ras.GMPPNP of these and other mutants discussed below are shown in FIG. 2A. Neither the wild-type protein, the pseudo wild-type (V327A, see methods), nor the V223K mutant exhibit detectable binding to N-Ras.GDP, consistent with the role of PI3Kγ as an effector. With the V223K mutant we obtained crystals of the Ras.PI3Kγ complex.

[0163] The overall organisation of the PI3Kγ catalytic subunit (Walker et al., 1999), which contains a Ras-binding domain (RBD), a C2 domain, a helical domain, and a catalytic domain, is preserved in the structure of the complex (FIG. 3). PI3Kγ interacts with many of the switch I residues of Ras with which the downstream effectors Raf and RalGDS also interact. However, a unique feature of the PI3Kγ.Ras complex is that the switch II region is also involved. Interactions with Ras switch II residues have previously only been observed in complexes of Ras with its upstream regulators, GAPs (Scheffzek et al., 1997) and GEFs (Boriack-Sjodin et al., 1998).

[0164] The most striking feature of the interaction with Ras is the ordering of a loop, residues 255 to 267, in the RBD (FIG. 3B), that is not visible in the free PI3Kγ structure, but is clearly defined in the electron density of the complex. This loop appears to act as a wedge that drastically rotates Ras with respect to Ras bound to other effectors, so that it establishes novel switch II contacts with the PI3Kγ RBD and catalytic domain.

[0165] Ras Binding Induces Ordering of a Critical Loop at the RBD.Ras Interface

[0166] The entropic cost of locking the PI3Kγ 255-267 loop into a single conformation might be offset by interactions formed between residues in the loop, and between the loop and the rest of the RBD. Eliminating these interactions or providing additional ones would affect the stability of the loop, and concomitantly decrease or increase the affinity of Ras for the kinase. In support of this hypothesis, the PI3Kγ mutants R226A, K256A, and D260A all eliminate hydrogen bonds or salt bridges that stabilise the 255-267 loop (FIG. 3A), and reduce binding by up to an order of magnitude (FIG. 2). The side chain of another attenuating mutant, Lys-254, points away from the Ras. Nevertheless, mutation of this residue to Ala greatly lowers the affinity of PI3Kγ for Ras, possibly by permitting more flexibility in the turn containing the critical residues Lys-255 and Lys-256. The complex-stabilising E267K mutant would permit the formation of an additional hydrogen bond from the mutant Lys-267 to the backbone amide oxygen of Phe-249, which could further stabilise the 255-267 loop and helix Ral. Apparently this also offsets any destabilisation that arises from placing Lys-267 and Lys-255 fairly near each other on the surface of the protein.

[0167] A predicted model of Ras bound to PI3Kγ (Walker et al., 1999) was based on the structure of the RalGDS RBD bound to Ras. In the current structure, with the 255-267 loop ordered and in place, steric clashes with this loop would prevent Ras from binding as predicted by our previous model. Instead, this loop wedges between Ras and the remainder of the RBD to rotate Ras toward the catalytic domain. The 255-267 loop is probably the primary determinant of the novel switch II contacts characteristic of the Ras.PI3K interaction (see below).

[0168] The Switch I Region of Ras Forms Typical Effector Interactions with PI3K

[0169] At the interface between Ras and the PI3K RBD, strand β2 of Ras is aligned with PI3K strand Rβ2 (FIG. 3B). This produces a continuous antiparallel β-sheet between the Ras and the RBD. The interaction is common to structures of Rap1A and Ras in complexes with Raf-RBD and RalGDS-RBD, respectively (Huang et al., 1998; Vetter et al., 1999). Most of the interactions between Ras and PI3Kγ are either hydrogen bonds or salt bridges (FIG. 3A), in agreement with the observation that the affinity of the two proteins is inversely related to the ionic strength of the buffer (data not shown). The area of the interface between the PI3Kγ RBD and Ras (1308 Å2) is similar to the surface areas of the Raf RBD (1333 Å2) and RalGDS RBD (1331 Å2) interfaces.

[0170] The effects of several PI3Kγ mutations that we made in the RBD.Ras interface are consistent with their apparent roles in forming switch I contacts. The T232D, K251A/E, and K255A mutations all eliminate binding by removing hydrogen bond donors or acceptors from the Ras switch I.PI3K interface, and in the case of the T232D and K251E mutations, by putting negatively charged PI3Kγ side chains into proximity with negatively charged side chains in Ras (FIG. 3A). K251E is the equivalent of the K227E mutant in PI3Kα, which also eliminates Ras binding (Rodriguez-Viciana et al., 1996b; Bondeva et al., 1998). The mechanism of the tighter binding V223K mutant can be explained in terms of interaction with the switch I region, because this mutation permits formation of an additional hydrogen bond between the RBD Lys-223 and Ras Glu-37.

[0171] Ras Makes Essential Interactions with PI3K using its Switch II Region

[0172] Unlike any other effectors downstream of Ras, PI3K makes critical interactions with the switch II region. Although early structural studies of Ras showed that both switch I and switch II regions of Ras changed conformation upon GTP binding and transforming mutants of Ras involving both of these regions have been reported, the structures of other effector RBDs in complexes with Ras showed only switch I interactions. In the PI3K complex, we observe extensive switch II contacts that are probably the consequence of the unique orientation of Ras relative to the RBD of PI3K. We have generated two mutants involving residues making switch II contacts, F221S and K234A. F221S eliminates hydrophobic interactions between PI3Kγ Phe-221 and Tyr-64 in switch II. Mutation of Lys-234 to Ala probably increases the Kd These mutants confirm the essential role of Ras Switch II in binding PI3Kγ. by eliminating hydrogen bonds to switch II residues Glu-63 and Tyr-64 (FIG. 3A). In addition, the Y64G Ras mutation abolishes a class IA PI3K binding (Moodie et al., 1995), suggesting that interaction with the Ras switch II is probably a general characteristic of PI3K.Ras complexes.

[0173] The PI3K Catalytic Domain Makes Direct Interactions with Switch II of Ras

[0174] Intriguingly, Ras directly contacts the C-terminal lobe of the PI3Kγ catalytic domain. Arg-73 in the switch II region of Ras is near enough to form a salt bridge with Glu-919 in the turn between helices kα5 and kα6. It was predicted that Arg-73 would be important in the interaction of Ras with other proteins (reviewed in (Polakis and McCormick, 1993), The structure of Ras with Sos confirmed the critical role of this residue in the interaction of Ras with nucleotide exchange factors (Boriack-Sjodin et al., 1998). This direct contact between the PI3K catalytic domain and Ras may be the consequence of the 255-267 loop of PI3K acting as a wedge to rotate the Ras toward the catalytic domain, and may be essential for induction of conformational change in the PI3Kγ (see below). This interaction may also be a feature of the Ras binding to PI3Kα, which has an even larger wedging loop in the location analogous to 255-267 of PI3Kγ.

[0175] Ras Binds to RBDs in Effector-Specific Orientations

[0176] Two structures of isolated RBD complexes with Ras or the Ras-like protein Rap1A have been previously solved. In FIG. 4, the Raf RBD.Rap1A complex (Nassar et al., 1995) and the RalGDS RBD.Ras complex (Huang et al., 1998) are compared with the PI3Kγ.Ras complex.

[0177] All three Ras.RBD complexes use a similar general mode of Ras-effector interaction, in which a β-sheet in the Ras and a β-sheet in the RBD are aligned to form a single β-sheet connecting the two proteins. Contacts between the switch I region of Ras and the RBD stabilise the interaction and ensure its dependence on Ras-GTP.

[0178] Despite the common mode of the Ras-RBD interaction, Ras discriminates among its effectors by rotating with respect to the RBD of a given effector. Ras bound to PI3Kγ is rotated by 35° relative to the centroid of Rap1A bound to the Raf RBD, and by 17° relative to Ras bound to the RalGDS RBD (FIG. 4A). In PI3Kγ, the length of helix Rα1 and the size of the subsequent loop (255-267) cause the profound rotation of Ras relative to the PI3Kγ RBD and the switch II interactions, for which there are no equivalents in the other Ras effector RBDs. The 255-267 loop appears larger in PI3Kγ and α than in PI3Ks β and δ. This is in agreement with the observation that PI3Kδ appears to differ from PI3Kα in its interaction with Ras (Kinashi et al., 2000).

[0179] Structural Insights Into Signalling Pathway-Specific Ras Mutations

[0180] Five Ras mutants have been defined that differentially affect Raf, RalGDS and PI3Kα signalling pathways. These mutants, T35S, E37G, D38E, Y40C and Y64G, have served as useful tools for unravelling networks of signal transduction pathways (White et al., 1995; Rodriguez-Viciana et al., 1997). The selective activation displayed by the switch I mutants (T35S, E37G, D38E and Y40C) appears to be due to subtle differences in the network of interactions that the switch I region makes in the three Ras/effector complexes. For the switch II mutant (Y64G), PI3K activation is probably selectively abrogated simply because PI3K forms a switch II contact whereas the other effectors do not (Vetter et al., 1999).

[0181] E37G is a Ras mutant that activates RalGDS but not Raf Although this mutant does not bind to or activate PI3Kα, it was recently shown that it does activate PI3Kδ (Kinashi et al., 2000). We find that, as with PI3Kδ, PI3Kγ binds Ras E37G similarly to wild type Ras (FIG. 2D). Glu-37 of Ras forms only a weak ionic interaction with, RalGDS, while it forms two hydrogen bonds with the guanidinium group of Arg-59 in Raf. Although we see a salt link between PI3Kγ Lys-223 and Ras Glu-37 in the structure of the V223K mutant, this interaction would not be possible with the wild type PI3Kγ. The lack of an interaction at this position in the wild type PI3Kγ is consistent with the unimpaired binding of PI3Kγ to the Ras E37G mutant. The residue in PI3Kα at the position equivalent to PI3Kγ Val-223 is also a Val (Val-193). This suggests that in PI3Kα another residue in the vicinity of Val-193 interacts with Ras Glu-37. One candidate for such a residue is Lys-206 of PI3Kα. Neither PI3Kγ nor PI3Kδ have a basic residue at the equivalent position.

[0182] D38E is a Ras mutant that selectively activates the Raf signalling pathway. PI3Kα (Rodriguez-Viciana et al., 1997), PI3Kδ (Kinashi et al., 2000) and PI3Kγ (FIG. 2D) all fail to bind the Ras D38E mutant. Asp-38 makes important contacts with the RBDs of all three effectors and D38A prevents Ras activation of these pathways. Although the D38E mutation conserves the negative charge, it introduces a larger residue into the intricate interface. This is only tolerated in Raf because Thr-68 of Raf leaves sufficient space in the vicinity of the side chain of Ras residue 38. In PI3Kγ, the bulky Gln-231 occupies the space analogous to Thr-68 of Raf and prevents Ras D38E binding (data not shown), while in RalGDS, this space is filled by Lys-32. In PI3Kα and PI3Kδ a bulky residue (Tyr-207 and Phe-203, respectively) also occupies this space.

[0183] One Ras mutation that has been used widely to selectively activate PI3Kα is the Y40C mutation. Surprisingly, this mutation eliminates binding to PI3Kδ (Kinashi et al., 2000) and greatly attenuates binding to PI3Kγ (FIG. 2D). Tyr-40 forms a putative hydrogen bond to Gln-231. Mutation of Tyr-40 to Cys probably eliminates this potential hydrogen bond and reduces PI3Kγ binding. Since Gln-231 is not conserved in PI3Kα, the hydrogen bond between Ras Tyr-40 may not be present, and the Y40C mutation would not affect binding. In complexes with Raf and RalGDS, the role of Ras Tyr-40 appears to be to restrict the motion of a nearby basic residue in the RBD (Arg-89 in Raf and Lys-32 in RalGDS) which forms a critical salt bridge with Ras Asp-38.

[0184] The Ras mutant Y64G selectively inhibits PI3K and neurofibromin binding (Moodie et al., 1995). Ras Tyr-64 in switch II forms an apparent hydrogen bond to the side chain of Lys-234 and makes hydrophobic contacts with Phe-221 of PI3Kγ. These interactions would be lost in the Y64G mutant. Tyr-64 also stacks with the carboxylate of Ras Glu-63, which forms a hydrogen bond with Lys-234. In contrast, neither Raf nor RalGDS make any contact with any residue in switch II (Nassar et al., 1995; Vetter et al., 1999).

[0185] Conformational Change in the Ras.PI3Kγ Complex

[0186] In addition to the induced fit of residues 255-267 at the interface with Ras, the structure of the Ras.PI3Kγ complex demonstrates that there are other more widespread conformational changes relative to the structure of the enzyme in the absence of Ras. Most of the conformational change, as illustrated in FIG. 5A, occurs in the C2 domain and the C-terminal lobe of the catalytic domain. When the structure of the free PB3Kγ and the structure of the complex are superimposed on the Ras-binding domain, the RMS deviation of the Cα atoms for the C2 domain is 1.7 Å. The RMS deviation of the Cα atoms for the C-terminal lobe of the catalytic domain is 1.9 Å. These values are well outside the cross-validated σA estimate of the error of the atom positions, which is 0.7 Å (based on the free set of reflections). Neither the N-terminal lobe of the catalytic domain nor the overall RBD show significant conformational change. The deviation of the helical domain in the structure of the complex from the free PI3Kγ structure is probably due to proteolysis in this domain (see methods).

[0187] In PI3Kγ, the ATP binding site is located between the N- and C-terminal lobes of the catalytic domain. As in the protein kinases (Zhou and Adams, 1997), mant-ADP release is slower than mant-ATP release (FIG. 2C). In the Ras.PI3Kγ complex, helix kα6 in the C-terminal lobe of the catalytic domain is pulled toward the Ras, and the entire ATP binding site moves with it, but apart from Asp-964 none of the residues in the ATP-binding site significantly change conformation. Consistent with this observation, neither the dissociation rate constants nor the Kd for either mant-ATP or mant-ADP change in the presence of Ras.

[0188] Unlike the ATP binding pocket, the putative phosphoinositide headgroup binding site appears to substantially change conformation upon Ras binding, as the C-terminal lobe of the catalytic domain pivots around the N-terminal lobe (FIG. 5B). Unfortunately, we have been unable to grow crystals in the presence of a phospholipid headgroup analogue, so we cannot be sure of the detailed structural changes relevant to headgroup binding. The backbones of helices kα9, kα10, and kα11, as well as kβ10 and kα7, which hold the activation loop in place, all substantially change position. Any allosteric mechanism of activation would probably involve a change in the affinity of phospholipid substrate binding, or perhaps an increase in the kcat of the enzyme. Attempts to quantify binding of short chain phospholipid analogues by intrinsic tryptophan fluorescence were unsuccessful due to lack of significant change in the protein fluorescence.

[0189] The consistency of the biochemical and structural data suggests that this structure demonstrates a plausible mode of Ras-induced conformational changes in PI3Kγ.

[0190] A Model for Ras Activation of PI3K

[0191] The structure of the Ras bound to PI3Kγ was used to construct a model of the activated complex on the plasma membrane. When the PI3Kγ active site is oriented towards the membrane surface and the C2 domain is binding phospholipids, the 20 residue tail of Ras (not present in the Ras construct used for crystallisation) has ample length to span the gap between the Ras effector domain and its farnesyl membrane anchor (FIG. 6). The loops of the PI3Kγ catalytic domain near the putative membrane interface all contain basic residues which could bind negatively charged phospholipid headgroups and hydrophobic residues capable of inserting into the membrane to help tether the enzyme in place.

[0192] In the Ras.PI3Kγ complex, the C2 and catalytic domains are spread apart, (FIG. 5A) presenting the active site to the membrane. This structural change may affect phosphoinositide binding in the active site, or increase the general affinity of the enzyme for the membrane interface. Although a substantial component of the Ras activation of PI3K appears to be via translocation to the membrane, an allosteric mechanism as suggested by the conformational change may also be a component of the Ras activation.

[0193] The synergistic stimulation of PI3Kγ by Gβγ and Ras is consistent with the emerging view of PI3Ks as integrators of multiple signalling pathways. The success of our design of both complex-stabilising and destabilising mutants, in conjunction with the novel interactions observed in the Ras.PI3Kγ structure, suggest new possibilities for the design of PI3K and Ras variants to control specific signal transduction pathways.

Example 3

[0194] Flexible Membrane Anchors

[0195] As described above, peptide ligands may incorporate a flexible membrane anchor, such that they are flexibly tethered to the membrane surface, for example, CAAX fused to a Ras-binding domain. This Example shows that such a membrane anchor containing peptide inhibits Ras signaling to a greater degree than one without a membrane anchor.

[0196] An isolated Raf-1 Ras Binding Domain (RBD) is capable of blocking tumour cell growth in soft agar (Fridman et al., 1994). We describe here a novel modification of the isolated Raf-1 RBD that increases its ability to competitively inhibit Ras signalling and permits it to block signal propagation from specific Ras isotypes. We make chimeric proteins containing the Raf RBD fused to the hypervariable, 20 amino acid C-termini of H-, K-, and N-Ras. These Ras “tails” target the RBD to the plasma membrane, presumably increasing its effective concentration in the vicinity of the Ras isotype with the same tail.

[0197] We measure Ras signalling activity by using the PathDetect system (Stratagene). We transfecte CHO cells, which have low endogenous levels of Ras (Choy et al., 1999), with 150 ng of a reporter plasmid (pFR-Luc) containing a Photinus pyralis (firefly) luciferase gene driven by a GAL4 promoter, and 10 ng of a plasmid (pFA2-Elk1-dbd) containing a GAL4 dbd-Elk1 activation domain fusion protein behind a CMV promoter. Activation of the MAP kinase signalling cascade leads to phosporylation of the Elk1 domain, dimerization of the GAL4-Elk-1 fusion protein, and transcription of Photinus luciferase. To control for transfection efficiency and levels of expression, we also transfect 10 ng of a reporter control plasmid (pRL-CMV) containing the gene for Renilla reniformis (sea pansy) luciferase behind a CMV promoter, and measure the luminescence generated by both Photinus and Renilla luciferase using the DualLuciferase assay system (Promega). All luciferase data are expressed as the ratio of Photinus luminescence to Renilla luminescence. When indicated, cells are transfected with 20 ng of pcDNA3 containing an RBD-Ras tail chimera protein and 1 ng of H-Ras G12V in an EXV vector. The total amount of transfected DNA is kept constant at 210 ng by addition of empty pcDNA3 vector.

[0198] The results are shown in FIG. 7 below.

[0199] CHO cells transfected with the reporter system plasmids (pFR-Luc, pFA2-Elk1-dbd, and pRL-CMV) exhibit relatively low ratios of Photinus to Renilla luciferase activity (0.17±0.06). Transfection of H-Ras G12V raises this ratio substantially, to 2.6±0.2. Addition of Raf-1 RBD with an H-Ras tail reduces the luciferase ratio to background levels (0.18±0.02). This represents a 93% inhibition of Ras signalling activity via the MAP kinase cascade. Mutation of the cysteine in the CAAX box to a serine (SAAX) reduces the effectiveness of the inhibitor 3 fold, as represented by a luciferase ratio of 0.57±0.14. The R89L mutation in the Raf RBD, which eliminates binding of the Raf RBD to Ras as previously described (Block et al., 1996), does not block Ras simulation of luciferase production, as the ratio is 2.26±0.53. Interestingly, Raf RBD with a K-Ras tail only reduces the luciferase ratio by 36%, to 1.68±0.03, and Raf RBD with an N-Ras tail does not inhibit H-Ras G12V stimulation of the luciferase ratio. Positive and negative control transfections with pFC-MEK1 (containing MEK-1 behind a CMV promoter) and pFC2-dbd (containing the Gal4-DBD without the Elk1 fusion) indicate that the reporter system was functioning properly.

[0200] From these data we conclude that the H-Ras tail is capable of targeting the Raf-1 RBD to the regions of the plasma membrane where H-Ras is active, increasing the effective concentration of the Raf-1 RBD and its ability to competitively inhibit H-Ras signal transduction. Chimeras containing the Raf-1 RBD fused to K- or N-Ras tails do not inhibit R-Ras signalling effectively. Therefore, RBD-Ras tail chimeras function as isotype-specific inhibitors of Ras signalling. Isotype-specific inhibitors of Ras signalling are useful for determining the biological functions of the Ras isotypes. Furthermore, these more effective RBD-based inhibitors are able to specifically inhibit the Ras proteins in diseases such as cancer where they are improperly activated.

[0201] Reference is made to the following publications: Fridman, M., Tikoo, A., Varga, M., Murphy, A., Nur, E. K. M. S., and Maruta, H. (1994). The minimal fragments of c-Raf-1 and NF1 that can suppress v-Ha-Ras-induced malignant phenotype. J Biol. Chem. 269, 30105-30108; Choy, E., Chiu, V. K., Silletti, J., Feoktistov, M., Morimoto, T., Michaelson, D., Ivanov, I. E., and Philips, M. R. (1999). Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell 98, 69-80; and Block, C., Janknecht, R., Herrmann, C., Nassar, N., and Wittinghofer, A. (1996). Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo. Nat. Struct. Biol. 3, 244-251.

[0202] Various modifications and variations of the described methods and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the described modes for carrying out the invention which are obvious to those skilled in chemistry or biology or related fields are intended to be covered by the present invention. All publications mentioned in the above specification are herein incorporated by reference.

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1TABLE 1Data collection, structure determination and refinement statisticsResolutionObservations/Completeness (last shell)Data set3(Å)unique reflections(%)Rsym4<I/σ> (last shell)Crystal 150-3.2146371/23318100.0 (100.0)0.11221.8 (3.6)Crystal 2150-3.0270093/2479182.4 (51.3)0.09414.7 (1.7)Merge250.0-3.0 232825/2582291.6 (50.5)0.10220.0 (1.7)Refinement statisticsResolutionReflectionsRfree5R.m.s.d. from ideality6Data set(Å)Protein atomsWatersWorkFreeRcryst5(% data used)BondsAnglesDihedralsMerge50.0-3.0740562427315100.2130.282 (5.4)0.0093 Å1.29°22.7°1Only 50 degrees were collected due to radiation damage caused by long exposure. 2The merged dataset was created by combining the data from crystals 1 and 2 in SCALA. 3The data from crystals 1 and 2 were collected at ESRF Beamline ID14-1. 4Rsym = ΣhklΣi|Ii(hkl) − <I(hkl)>|/ΣhklΣi Ii(hkl) 5Rcryst and Rfree = Σ|Fobs − Fcalc|/ΣFobs; Rfree calculated with the percentage of the data shown in parentheses 6R.m.s deviations for bond angles and lengths in regard to Engh & Huber parameters (Engh and Huber, 1991)

[0274]

2

REMARK Written by O version 7.0.0

REMARK Fri Jun 2 20:32:07 2000

CRYST1
113.635
113.635
183.881
90.00
90.00
120.00

ORIGX1
1.000000
0.000000
0.000000
0.00000

ORIGX2
0.000000
1.000000
0.000000
0.00000

ORIGX3
0.000000
0.000000
1.000000
0.00000

SCALE1
0.008800
0.005080
0.000000
0.00000

SCALE2
0.000000
0.010161
0.000000
0.00000

SCALE3
0.000000
0.000000
0.005438
0.00000

ATOM
1
CB
ALA
A
143
76.520
95.646
61.236
1.00
71.64
6

ATOM
2
C
ALA
A
143
76.296
97.493
62.914
1.00
71.01
6

ATOM
3
O
ALA
A
143
76.857
98.203
63.747
1.00
70.81
8

ATOM
4
N
ALA
A
143
78.505
96.948
61.921
1.00
71.67
7

ATOM
5
CA
ALA
A
143
77.037
97.016
61.667
1.00
71.57
6

ATOM
6
N
SER
A
144
75.033
97.096
63.036
1.00
70.60
7

ATOM
7
CA
SER
A
144
74.215
97.487
64.177
1.00
69.78
6

ATOM
8
CB
SER
A
144
72.792
96.942
64.017
1.00
70.14
6

ATOM
9
OG
SER
A
144
72.106
97.581
62.956
1.00
70.82
8

ATOM
10
C
SER
A
144
74.792
96.997
65.499
1.00
69.28
6

ATOM
11
O
SER
A
144
75.759
96.236
65.529
1.00
69.54
8

ATOM
12
N
GLU
A
145
74.190
97.447
66.595
1.00
68.35
7

ATOM
13
CA
GLU
A
145
74.620
97.041
67.924
1.00
67.09
6

ATOM
14
CB
GLU
A
145
73.886
97.865
68.985
1.00
68.59
6

ATOM
15
CG
GLU
A
145
74.608
97.968
70.326
1.00
70.94
6

ATOM
16
CD
GLU
A
145
74.801
96.625
71.002
1.00
71.79
6

ATOM
17
OE1
GLU
A
145
73.790
96.009
71.403
1.00
71.80
8

ATOM
18
OE2
GLU
A
145
75.966
96.186
71.129
1.00
72.30
8

ATOM
19
C
GLU
A
145
74.238
95.566
68.034
1.00
65.70
6

ATOM
20
O
GLU
A
145
74.774
94.825
68.857
1.00
64.95
8

ATOM
21
N
GLU
A
146
73.307
95.156
67.177
1.00
63.78
7

ATOM
22
CA
GLU
A
146
72.823
93.782
67.121
1.00
62.92
6

ATOM
23
CB
GLU
A
146
71.735
93.666
66.050
1.00
64.45
6

ATOM
24
CG
GLU
A
146
70.352
93.295
66.564
1.00
67.31
6

ATOM
25
CD
GLU
A
146
70.227
91.823
66.931
1.00
69.16
6

ATOM
26
OE1
GLU
A
146
70.570
90.967
66.085
1.00
69.60
8

ATOM
27
OE2
GLU
A
146
69.777
91.522
68.058
1.00
70.04
8

ATOM
28
C
GLU
A
146
73.964
92.827
66.785
1.00
61.15
6

ATOM
29
O
GLU
A
146
74.273
91.916
67.555
1.00
60.60
8

ATOM
30
N
SER
A
147
74.583
93.049
65.627
1.00
59.35
7

ATOM
31
CA
SER
A
147
75.686
92.221
65.153
1.00
57.82
6

ATOM
32
CB
SER
A
147
76.178
92.725
63.794
1.00
58.77
6

ATOM
33
OG
SER
A
147
76.730
94.023
63.902
1.00
60.62
8

ATOM
34
C
SER
A
147
76.850
92.198
66.136
1.00
55.79
6

ATOM
35
O
SER
A
147
77.498
91.169
66.314
1.00
54.64
8

ATOM
36
N
GLN
A
148
77.117
93.339
66.760
1.00
53.66
7

ATOM
37
CA
GLN
A
148
78.197
93.431
67.730
1.00
52.68
6

ATOM
38
CB
GLN
A
148
78.389
94.886
68.167
1.00
54.73
6

ATOM
39
CG
GLN
A
148
79.100
95.734
67.123
1.00
57.72
6

ATOM
40
CD
GLN
A
148
78.605
97.167
67.090
1.00
59.75
6

ATOM
41
OE1
GLN
A
148
78.633
97.873
68.099
1.00
60.43
8

ATOM
42
NE2
GLN
A
148
78.150
97.605
65.922
1.00
60.03
7

ATOM
43
C
GLN
A
148
77.886
92.553
68.933
1.00
50.70
6

ATOM
44
O
GLN
A
148
78.740
91.789
69.390
1.00
50.82
8

ATOM
45
N
ALA
A
149
76.661
92.659
69.440
1.00
47.06
7

ATOM
46
CA
ALA
A
149
76.237
91.862
70.584
1.00
44.11
6

ATOM
47
CB
ALA
A
149
74.816
92.231
70.982
1.00
43.91
6

ATOM
48
C
ALA
A
149
76.311
90.380
70.225
1.00
41.90
6

ATOM
49
O
ALA
A
149
76.597
89.542
71.077
1.00
40.82
8

ATOM
50
N
PHE
A
150
76.046
90.069
68.961
1.00
39.57
7

ATOM
51
CA
PHE
A
150
76.094
88.689
68.484
1.00
39.29
6

ATOM
52
CB
PHE
A
150
75.490
88.604
67.076
1.00
38.89
6

ATOM
53
CG
PHE
A
150
75.454
87.210
66.503
1.00
40.47
6

ATOM
54
CD1
PHE
A
150
74.739
86.198
67.136
1.00
39.24
6

ATOM
55
CD2
PHE
A
150
76.134
86.910
65.324
1.00
38.01
6

ATOM
56
CE1
PHE
A
150
74.703
84.910
66.603
1.00
39.21
6

ATOM
57
CE2
PHE
A
150
76.102
85.621
64.784
1.00
38.46
6

ATOM
58
CZ
PHE
A
150
75.387
84.624
65.425
1.00
37.98
6

ATOM
59
C
PHE
A
150
77.545
88.189
68.479
1.00
38.70
6

ATOM
60
O
PHE
A
150
77.841
87.125
69.017
1.00
36.79
8

ATOM
61
N
GLN
A
151
78.450
88.962
67.878
1.00
38.39
7

ATOM
62
CA
GLN
A
151
79.853
88.568
67.839
1.00
38.19
6

ATOM
63
CB
GLN
A
151
80.700
89.645
67.154
1.00
39.36
6

ATOM
64
CG
GLN
A
151
82.142
89.215
66.846
1.00
40.06
6

ATOM
65
CD
GLN
A
151
82.219
88.004
65.917
1.00
41.30
6

ATOM
66
OE1
GLN
A
151
81.747
88.043
64.779
1.00
40.98
8

ATOM
67
NE2
GLN
A
151
82.816
86.924
66.404
1.00
40.56
7

ATOM
68
C
GLN
A
151
80.307
88.370
69.281
1.00
38.33
6

ATOM
69
O
GLN
A
151
81.091
87.474
69.580
1.00
36.49
8

ATOM
70
N
ARG
A
152
79.792
89.210
70.173
1.00
38.32
7

ATOM
71
CA
ARG
A
152
80.107
89.125
71.591
1.00
39.98
6

ATOM
72
CB
ARG
A
152
79.411
90.269
72.346
1.00
44.06
6

ATOM
73
CG
ARG
A
152
79.327
90.103
73.862
1.00
48.48
6

ATOM
74
CD
ARG
A
152
78.764
91.371
74.532
1.00
54.07
6

ATOM
75
NE
ARG
A
152
78.504
91.182
75.963
1.00
56.58
7

ATOM
76
CZ
ARG
A
152
78.154
92.152
76.806
1.00
57.98
6

ATOM
77
NH1
ARG
A
152
78.017
93.401
76.378
1.00
57.77
7

ATOM
78
NH2
ARG
A
152
77.937
91.873
78.088
1.00
57.84
7

ATOM
79
C
ARG
A
152
79.668
87.772
72.153
1.00
39.21
6

ATOM
80
O
ARG
A
152
80.373
87.174
72.965
1.00
37.67
8

ATOM
81
N
GLN
A
153
78.502
87.291
71.725
1.00
37.26
7

ATOM
82
CA
GLN
A
153
78.008
86.004
72.204
1.00
37.34
6

ATOM
83
CB
GLN
A
153
76.561
85.778
71.760
1.00
39.17
6

ATOM
84
CG
GLN
A
153
75.949
84.483
72.295
1.00
44.50
6

ATOM
85
CD
GLN
A
153
74.608
84.148
71.656
1.00
48.57
6

ATOM
86
OE1
GLN
A
153
73.986
83.131
71.981
1.00
49.71
8

ATOM
87
NE2
GLN
A
153
74.157
85.002
70.742
1.00
49.54
7

ATOM
88
C
GLN
A
153
78.897
84.882
71.657
1.00
37.45
6

ATOM
89
O
GLN
A
153
79.309
83.987
72.399
1.00
35.62
8

ATOM
90
N
LEU
A
154
79.193
84.934
70.361
1.00
34.90
7

ATOM
91
CA
LEU
A
154
80.047
83.920
69.751
1.00
34.78
6

ATOM
92
CB
LEU
A
154
80.311
84.259
68.273
1.00
33.45
6

ATOM
93
CG
LEU
A
154
79.100
84.184
67.333
1.00
32.75
6

ATOM
94
CD1
LEU
A
154
79.476
84.690
65.951
1.00
33.24
6

ATOM
95
CD2
LEU
A
154
78.599
82.751
67.246
1.00
34.70
6

ATOM
96
C
LEU
A
154
81.364
83.853
70.532
1.00
32.82
6

ATOM
97
O
LEU
A
154
81.831
82.774
70.887
1.00
30.86
8

ATOM
98
N
THR
A
155
81.946
85.008
70.822
1.00
31.34
7

ATOM
99
CA
THR
A
155
83.200
85.051
71.573
1.00
31.85
6

ATOM
100
CB
THR
A
155
83.619
86.507
71.845
1.00
32.89
6

ATOM
101
OG1
THR
A
155
83.931
87.137
70.598
1.00
32.79
8

ATOM
102
CG2
THR
A
155
84.845
86.569
72.755
1.00
30.71
6

ATOM
103
C
THR
A
155
83.141
84.274
72.894
1.00
31.49
6

ATOM
104
O
THR
A
155
84.083
83.554
73.237
1.00
30.84
8

ATOM
105
N
ALA
A
156
82.037
84.397
73.625
1.00
29.88
7

ATOM
106
CA
ALA
A
156
81.901
83.696
74.900
1.00
30.23
6

ATOM
107
CB
ALA
A
156
80.731
84.274
75.700
1.00
31.61
6

ATOM
108
C
ALA
A
156
81.731
82.185
74.723
1.00
30.01
6

ATOM
109
O
ALA
A
156
82.153
81.401
75.578
1.00
30.85
8

ATOM
110
N
LEU
A
157
81.117
81.776
73.620
1.00
27.62
7

ATOM
111
CA
LEU
A
157
80.921
80.356
73.331
1.00
28.83
6

ATOM
112
CB
LEU
A
157
79.888
80.171
72.212
1.00
28.62
6

ATOM
113
CG
LEU
A
157
78.420
80.404
72.577
1.00
29.59
6

ATOM
114
CD1
LEU
A
157
77.547
80.334
71.345
1.00
28.37
6

ATOM
115
CD2
LEU
A
157
78.003
79.356
73.589
1.00
28.01
6

ATOM
116
C
LEU
A
157
82.238
79.718
72.895
1.00
29.34
6

ATOM
117
O
LEU
A
157
82.577
78.600
73.318
1.00
29.47
8

ATOM
118
N
ILE
A
158
82.962
80.444
72.045
1.00
28.70
7

ATOM
119
CA
ILE
A
158
84.241
80.014
71.493
1.00
28.13
6

ATOM
120
CB
ILE
A
158
84.735
81.004
70.410
1.00
31.27
6

ATOM
121
CG2
ILE
A
158
86.089
80.550
69.859
1.00
29.81
6

ATOM
122
CG1
ILE
A
158
83.706
81.127
69.269
1.00
29.92
6

ATOM
123
CD1
ILE
A
158
83.645
79.951
68.361
1.00
36.11
6

ATOM
124
C
ILE
A
158
85.304
79.944
72.587
1.00
29.28
6

ATOM
125
O
ILE
A
158
86.031
78.957
72.703
1.00
26.55
8

ATOM
126
N
GLY
A
159
85.385
80.997
73.392
1.00
28.68
7

ATOM
127
CA
GLY
A
159
86.379
81.043
74.446
1.00
31.13
6

ATOM
128
C
GLY
A
159
87.588
81.769
73.898
1.00
31.36
6

ATOM
129
O
GLY
A
159
88.649
81.793
74.511
1.00
33.39
8

ATOM
130
N
TYR
A
160
87.415
82.358
72.720
1.00
31.49
7

ATOM
131
CA
TYR
A
160
88.476
83.102
72.052
1.00
31.09
6

ATOM
132
CB
TYR
A
160
89.356
82.146
71.232
1.00
30.13
6

ATOM
133
CG
TYR
A
160
90.676
82.752
70.792
1.00
30.00
6

ATOM
134
CD1
TYR
A
160
91.763
82.821
71.673
1.00
31.76
6

ATOM
135
CE1
TYR
A
160
92.967
83.423
71.293
1.00
29.41
6

ATOM
136
CD2
TYR
A
160
90.823
83.299
69.520
1.00
29.39
6

ATOM
137
CE2
TYR
A
160
92.015
83.904
69.128
1.00
31.70
6

ATOM
138
CZ
TYR
A
160
93.083
83.962
70.020
1.00
32.23
6

ATOM
139
OH
TYR
A
160
94.260
84.556
69.632
1.00
35.03
8

ATOM
140
C
TYR
A
160
87.821
84.120
71.117
1.00
31.93
6

ATOM
141
O
TYR
A
160
86.816
83.818
70.475
1.00
31.27
8

ATOM
142
N
ASP
A
161
88.383
85.321
71.033
1.00
33.22
7

ATOM
143
CA
ASP
A
161
87.815
86.341
70.153
1.00
36.53
6

ATOM
144
CB
ASP
A
161
87.940
87.731
70.784
1.00
36.69
6

ATOM
145
CG
ASP
A
161
87.509
88.843
69.838
1.00
39.02
6

ATOM
146
OD1
ASP
A
161
86.627
88.612
68.981
1.00
34.49
8

ATOM
147
OD2
ASP
A
161
88.049
89.961
69.963
1.00
43.82
8

ATOM
148
C
ASP
A
161
88.491
86.334
68.790
1.00
37.22
6

ATOM
149
O
ASP
A
161
89.610
86.830
68.640
1.00
37.03
8

ATOM
150
N
VAL
A
162
87.797
85.791
67.794
1.00
38.04
7

ATOM
151
CA
VAL
A
162
88.351
85.702
66.453
1.00
40.68
6

ATOM
152
CB
VAL
A
162
87.527
84.743
65.563
1.00
40.26
6

ATOM
153
CG1
VAL
A
162
87.529
83.345
66.178
1.00
37.44
6

ATOM
154
CG2
VAL
A
162
86.111
85.261
65.393
1.00
37.74
6

ATOM
155
C
VAL
A
162
88.505
87.038
65.737
1.00
43.93
6

ATOM
156
O
VAL
A
162
89.039
87.085
64.631
1.00
45.93
8

ATOM
157
N
THR
A
163
88.035
88.121
66.348
1.00
46.97
7

ATOM
158
CA
THR
A
163
88.196
89.435
65.728
1.00
49.88
6

ATOM
159
CB
THR
A
163
87.009
90.393
66.034
1.00
48.12
6

ATOM
160
OG1
THR
A
163
87.036
90.782
67.412
1.00
47.75
8

ATOM
161
CG2
THR
A
163
85.687
89.715
65.730
1.00
48.24
6

ATOM
162
C
THR
A
163
89.489
90.027
66.290
1.00
52.52
6

ATOM
163
O
THR
A
163
89.908
91.118
65.913
1.00
53.81
8

ATOM
164
N
ASP
A
164
90.116
89.281
67.194
1.00
55.39
7

ATOM
165
CA
ASP
A
164
91.369
89.700
67.813
1.00
57.64
6

ATOM
166
CB
ASP
A
164
91.578
88.950
69.132
1.00
60.50
6

ATOM
167
CG
ASP
A
164
92.927
89.244
69.769
1.00
62.49
6

ATOM
168
OD1
ASP
A
164
93.114
90.369
70.283
1.00
63.75
8

ATOM
169
OD2
ASP
A
164
93.801
88.349
69.750
1.00
63.20
8

ATOM
170
C
ASP
A
164
92.536
89.406
66.872
1.00
57.90
6

ATOM
171
O
ASP
A
164
92.810
88.247
66.557
1.00
58.81
8

ATOM
172
N
VAL
A
165
93.224
90.451
66.425
1.00
57.24
7

ATOM
173
CA
VAL
A
165
94.359
90.281
65.525
1.00
55.84
6

ATOM
174
CB
VAL
A
165
94.210
91.154
64.259
1.00
56.35
6

ATOM
175
CG1
VAL
A
165
95.185
90.690
63.193
1.00
57.60
6

ATOM
176
CG2
VAL
A
165
92.783
91.078
63.739
1.00
57.20
6

ATOM
177
C
VAL
A
165
95.624
90.683
66.263
1.00
54.43
6

ATOM
178
O
VAL
A
165
96.450
91.435
65.752
1.00
55.37
8

ATOM
179
N
SER
A
166
95.767
90.153
67.471
1.00
53.72
7

ATOM
180
CA
SER
A
166
96.904
90.447
68.336
1.00
52.28
6

ATOM
181
CB
SER
A
166
96.477
90.245
69.795
1.00
52.70
6

ATOM
182
OG
SER
A
166
97.472
90.694
70.694
1.00
56.25
8

ATOM
183
C
SER
A
166
98.179
89.633
68.057
1.00
50.66
6

ATOM
184
O
SER
A
166
99.297
90.128
68.245
1.00
51.68
8

ATOM
185
N
ASN
A
167
98.008
88.395
67.607
1.00
46.77
7

ATOM
186
CA
ASN
A
167
99.131
87.500
67.337
1.00
41.94
6

ATOM
187
CB
ASN
A
167
99.069
86.325
68.325
1.00
38.15
6

ATOM
188
CG
ASN
A
167
100.193
85.325
68.135
1.00
37.67
6

ATOM
189
OD1
ASN
A
167
101.357
85.696
67.994
1.00
33.19
8

ATOM
190
ND2
ASN
A
167
99.847
84.040
68.154
1.00
33.62
7

ATOM
191
C
ASN
A
167
99.077
87.000
65.893
1.00
40.79
6

ATOM
192
O
ASN
A
167
98.958
85.800
65.641
1.00
35.54
8

ATOM
193
N
VAL
A
168
99.164
87.932
64.946
1.00
40.77
7

ATOM
194
CA
VAL
A
168
99.113
87.590
63.531
1.00
41.64
6

ATOM
195
CB
VAL
A
168
97.714
87.865
62.954
1.00
41.95
6

ATOM
196
CG1
VAL
A
168
97.589
87.243
61.595
1.00
44.58
6

ATOM
197
CG2
VAL
A
168
96.650
87.315
63.873
1.00
43.63
6

ATOM
198
C
VAL
A
168
100.129
88.386
62.717
1.00
42.25
6

ATOM
199
O
VAL
A
168
100.522
89.488
63.103
1.00
43.63
8

ATOM
200
N
HIS
A
169
100.560
87.822
61.592
1.00
40.30
7

ATOM
201
CA
HIS
A
169
101.508
88.499
60.721
1.00
38.84
6

ATOM
202
CB
HIS
A
169
102.896
87.844
60.832
1.00
41.33
6

ATOM
203
CG
HIS
A
169
102.958
86.435
60.324
1.00
43.64
6

ATOM
204
CD2
HIS
A
169
102.340
85.831
59.280
1.00
42.44
6

ATOM
205
ND1
HIS
A
169
103.770
85.477
60.895
1.00
43.55
7

ATOM
206
CE1
HIS
A
169
103.649
84.344
60.225
1.00
44.37
6

ATOM
207
NE2
HIS
A
169
102.788
84.532
59.241
1.00
43.31
7

ATOM
208
C
HIS
A
169
101.015
88.514
59.265
1.00
36.27
6

ATOM
209
O
HIS
A
169
101.766
88.840
58.345
1.00
36.21
8

ATOM
210
N
ASP
A
170
99.748
88.154
59.068
1.00
32.58
7

ATOM
211
CA
ASP
A
170
99.137
88.144
57.742
1.00
31.52
6

ATOM
212
CB
ASP
A
170
99.689
86.984
56.890
1.00
33.07
6

ATOM
213
CG
ASP
A
170
99.198
85.612
57.342
1.00
35.23
6

ATOM
214
OD1
ASP
A
170
98.628
85.483
58.449
1.00
35.14
8

ATOM
215
OD2
ASP
A
170
99.398
84.645
56.577
1.00
39.13
8

ATOM
216
C
ASP
A
170
97.632
88.033
57.928
1.00
29.97
6

ATOM
217
O
ASP
A
170
97.155
88.027
59.056
1.00
31.02
8

ATOM
218
N
ASP
A
171
96.870
87.954
56.847
1.00
30.31
7

ATOM
219
CA
ASP
A
171
95.420
87.864
56.999
1.00
31.11
6

ATOM
220
CB
ASP
A
171
94.725
88.884
56.090
1.00
34.54
6

ATOM
221
CG
ASP
A
171
94.836
88.523
54.622
1.00
36.88
6

ATOM
222
OD1
ASP
A
171
94.145
89.162
53.796
1.00
38.32
8

ATOM
223
OD2
ASP
A
171
95.620
87.602
54.297
1.00
36.73
8

ATOM
224
C
ASP
A
171
94.854
86.474
56.704
1.00
29.95
6

ATOM
225
O
ASP
A
171
93.721
86.351
56.232
1.00
30.44
8

ATOM
226
N
GLU
A
172
95.604
85.416
56.983
1.00
28.56
7

ATOM
227
CA
GLU
A
172
95.044
84.104
56.670
1.00
26.65
6

ATOM
228
CB
GLU
A
172
96.064
82.982
56.871
1.00
26.23
6

ATOM
229
CG
GLU
A
172
95.606
81.689
56.190
1.00
25.27
6

ATOM
230
CD
GLU
A
172
96.448
80.479
56.538
1.00
26.71
6

ATOM
231
OE1
GLU
A
172
97.515
80.637
57.162
1.00
25.24
8

ATOM
232
OE2
GLU
A
172
96.034
79.360
56.174
1.00
24.99
8

ATOM
233
C
GLU
A
172
93.773
83.794
57.460
1.00
25.87
6

ATOM
234
O
GLU
A
172
92.801
83.279
56.897
1.00
24.66
8

ATOM
235
N
LEU
A
173
93.769
84.110
58.756
1.00
26.09
7

ATOM
236
CA
LEU
A
173
92.601
83.846
59.601
1.00
28.17
6

ATOM
237
CB
LEU
A
173
92.901
84.213
61.068
1.00
29.49
6

ATOM
238
CG
LEU
A
173
93.949
83.351
61.785
1.00
30.42
6

ATOM
239
CD1
LEU
A
173
94.470
84.071
63.025
1.00
31.22
6

ATOM
240
CD2
LEU
A
173
93.333
81.999
62.166
1.00
30.93
6

ATOM
241
C
LEU
A
173
91.358
84.588
59.106
1.00
29.38
6

ATOM
242
O
LEU
A
173
90.288
83.996
59.012
1.00
28.61
8

ATOM
243
N
GLU
A
174
91.486
85.876
58.785
1.00
30.24
7

ATOM
244
CA
GLU
A
174
90.329
86.625
58.277
1.00
32.47
6

ATOM
245
CB
GLU
A
174
90.679
88.099
58.050
1.00
35.00
6

ATOM
246
CG
GLU
A
174
89.984
89.076
58.994
1.00
40.36
6

ATOM
247
CD
GLU
A
174
88.492
88.813
59.146
1.00
40.72
6

ATOM
248
OE1
GLU
A
174
87.765
88.774
58.124
1.00
41.42
8

ATOM
249
OE2
GLU
A
174
88.043
88.656
60.299
1.00
40.30
8

ATOM
250
C
GLU
A
174
89.908
86.015
56.938
1.00
30.38
6

ATOM
251
O
GLU
A
174
88.728
85.878
56.639
1.00
31.05
8

ATOM
252
N
PHE
A
175
90.903
85.659
56.140
1.00
30.71
7

ATOM
253
CA
PHE
A
175
90.683
85.049
54.838
1.00
32.03
6

ATOM
254
CB
PHE
A
175
92.043
84.752
54.196
1.00
35.09
6

ATOM
255
CG
PHE
A
175
91.961
84.202
52.795
1.00
38.72
6

ATOM
256
CD1
PHE
A
175
91.707
85.043
51.713
1.00
39.86
6

ATOM
257
CD2
PHE
A
175
92.158
82.844
52.557
1.00
39.25
6

ATOM
258
CE1
PHE
A
175
91.657
84.538
50.416
1.00
41.39
6

ATOM
259
CE2
PHE
A
175
92.109
82.328
51.263
1.00
41.71
6

ATOM
260
CZ
PHE
A
175
91.858
83.176
50.191
1.00
41.41
6

ATOM
261
C
PHE
A
175
89.892
83.748
55.027
1.00
31.25
6

ATOM
262
O
PHE
A
175
88.981
83.432
54.263
1.00
30.51
8

ATOM
263
N
THR
A
176
90.248
82.992
56.055
1.00
29.53
7

ATOM
264
CA
THR
A
176
89.568
81.738
56.318
1.00
27.79
6

ATOM
265
CB
THR
A
176
90.375
80.904
57.319
1.00
27.60
6

ATOM
266
OG1
THR
A
176
91.638
80.579
56.721
1.00
23.25
8

ATOM
267
CG2
THR
A
176
89.628
79.619
57.685
1.00
25.40
6

ATOM
268
C
THR
A
176
88.127
81.953
56.785
1.00
27.11
6

ATOM
269
O
THR
A
176
87.219
81.252
56.337
1.00
27.55
8

ATOM
270
N
ARG
A
177
87.901
82.935
57.653
1.00
26.93
7

ATOM
271
CA
ARG
A
177
86.534
83.214
58.109
1.00
27.84
6

ATOM
272
CB
ARG
A
177
86.498
84.436
59.035
1.00
25.62
6

ATOM
273
CG
ARG
A
177
87.341
84.335
60.298
1.00
29.23
6

ATOM
274
CD
ARG
A
177
87.188
85.612
61.127
1.00
30.71
6

ATOM
275
NE
ARG
A
177
85.822
85.741
61.634
1.00
33.35
7

ATOM
276
CZ
ARG
A
177
85.200
86.896
61.860
1.00
36.50
6

ATOM
277
NH1
ARG
A
177
85.812
88.052
61.627
1.00
36.25
7

ATOM
278
NH2
ARG
A
177
83.956
86.895
62.320
1.00
36.96
7

ATOM
279
C
ARG
A
177
85.651
83.490
56.883
1.00
29.24
6

ATOM
280
O
ARG
A
177
84.533
82.976
56.778
1.00
29.65
8

ATOM
281
N
ARG
A
178
86.150
84.303
55.955
1.00
29.32
7

ATOM
282
CA
ARG
A
178
85.376
84.612
54.750
1.00
33.07
6

ATOM
283
CB
ARG
A
178
86.090
85.667
53.902
1.00
34.30
6

ATOM
284
CG
ARG
A
178
86.228
87.031
54.554
1.00
39.30
6

ATOM
285
CD
ARG
A
178
86.838
88.015
53.571
1.00
44.34
6

ATOM
286
NE
ARG
A
178
86.969
89.359
54.126
1.00
49.81
7

ATOM
287
CZ
ARG
A
178
87.777
89.675
55.133
1.00
52.73
6

ATOM
288
NH1
ARG
A
178
88.527
88.737
55.699
1.00
54.48
7

ATOM
289
NH2
ARG
A
178
87.848
90.929
55.566
1.00
52.35
7

ATOM
290
C
ARG
A
178
85.160
83.353
53.907
1.00
32.02
6

ATOM
291
O
ARG
A
178
84.057
83.083
53.431
1.00
31.99
8

ATOM
292
N
GLY
A
179
86.223
82.576
53.732
1.00
32.13
7

ATOM
293
CA
GLY
A
179
86.123
81.365
52.935
1.00
31.44
6

ATOM
294
C
GLY
A
179
85.145
80.311
53.424
1.00
30.96
6

ATOM
295
O
GLY
A
179
84.570
79.584
52.616
1.00
30.97
8

ATOM
296
N
LEU
A
180
84.947
80.211
54.737
1.00
29.65
7

ATOM
297
CA
LEU
A
180
84.042
79.192
55.264
1.00
30.64
6

ATOM
298
CB
LEU
A
180
84.433
78.842
56.707
1.00
28.91
6

ATOM
299
CG
LEU
A
180
85.874
78.336
56.827
1.00
27.68
6

ATOM
300
CD1
LEU
A
180
86.207
78.064
58.290
1.00
22.85
6

ATOM
301
CD2
LEU
A
180
86.052
77.064
55.992
1.00
24.81
6

ATOM
302
C
LEU
A
180
82.557
79.543
55.178
1.00
29.37
6

ATOM
303
O
LEU
A
180
81.698
78.706
55.461
1.00
29.31
8

ATOM
304
N
VAL
A
181
82.254
80.773
54.771
1.00
32.29
7

ATOM
305
CA
VAL
A
181
80.861
81.198
54.624
1.00
33.26
6

ATOM
306
CB
VAL
A
181
80.763
82.666
54.141
1.00
34.48
6

ATOM
307
CG1
VAL
A
181
79.358
82.956
53.626
1.00
35.84
6

ATOM
308
CG2
VAL
A
181
81.093
83.612
55.288
1.00
35.87
6

ATOM
309
C
VAL
A
181
80.118
80.301
53.633
1.00
32.12
6

ATOM
310
O
VAL
A
181
79.062
79.758
53.944
1.00
30.27
8

ATOM
311
N
THR
A
182
80.674
80.140
52.440
1.00
33.84
7

ATOM
312
CA
THR
A
182
80.047
79.304
51.418
1.00
34.31
6

ATOM
313
CB
THR
A
182
80.925
79.251
50.136
1.00
35.76
6

ATOM
314
OG1
THR
A
182
80.967
80.551
49.534
1.00
34.92
8

ATOM
315
CG2
THR
A
182
80.365
78.242
49.132
1.00
35.91
6

ATOM
316
C
THR
A
182
79.766
77.871
51.894
1.00
34.51
6

ATOM
317
O
THR
A
182
78.632
77.392
51.811
1.00
36.33
8

ATOM
318
N
PRO
A
183
80.794
77.165
52.401
1.00
33.19
7

ATOM
319
CD
PRO
A
183
82.198
77.585
52.542
1.00
33.25
6

ATOM
320
CA
PRO
A
183
80.616
75.787
52.878
1.00
30.93
6

ATOM
321
CB
PRO
A
183
81.976
75.458
53.488
1.00
33.18
6

ATOM
322
CG
PRO
A
183
82.912
76.261
52.661
1.00
34.43
6

ATOM
323
C
PRO
A
183
79.488
75.672
53.896
1.00
28.42
6

ATOM
324
O
PRO
A
183
78.671
74.746
53.846
1.00
27.52
8

ATOM
325
N
ARG
A
184
79.451
76.618
54.824
1.00
27.37
7

ATOM
326
CA
ARG
A
184
78.422
76.633
55.859
1.00
29.33
6

ATOM
327
CB
ARG
A
184
78.728
77.710
56.905
1.00
27.77
6

ATOM
328
CG
ARG
A
184
77.528
78.084
57.765
1.00
30.74
6

ATOM
329
CD
ARG
A
184
77.884
79.150
58.781
1.00
29.78
6

ATOM
330
NE
ARG
A
184
78.764
80.172
58.233
1.00
37.34
7

ATOM
331
CZ
ARG
A
184
78.375
81.414
57.960
1.00
38.97
6

ATOM
332
NH1
ARG
A
184
77.122
81.777
58.196
1.00
46.41
7

ATOM
333
NH2
ARG
A
184
79.222
82.290
57.442
1.00
35.65
7

ATOM
334
C
ARG
A
184
77.027
76.882
55.289
1.00
30.29
6

ATOM
335
O
ARG
A
184
76.105
76.101
55.526
1.00
30.35
8

ATOM
336
N
MET
A
185
76.868
77.976
54.549
1.00
32.41
7

ATOM
337
CA
MET
A
185
75.555
78.296
53.985
1.00
34.11
6

ATOM
338
CB
MET
A
185
75.618
79.595
53.175
1.00
35.65
6

ATOM
339
CG
MET
A
185
76.042
80.805
53.994
1.00
41.17
6

ATOM
340
SD
MET
A
185
75.773
82.377
53.135
1.00
49.08
16

ATOM
341
CE
MET
A
185
76.863
82.178
51.722
1.00
47.55
6

ATOM
342
C
MET
A
185
75.018
77.164
53.121
1.00
32.33
6

ATOM
343
O
MET
A
185
73.834
76.849
53.178
1.00
32.67
8

ATOM
344
N
ALA
A
186
75.894
76.541
52.337
1.00
31.91
7

ATOM
345
CA
ALA
A
186
75.488
75.444
51.465
1.00
31.35
6

ATOM
346
CB
ALA
A
186
76.654
75.007
50.600
1.00
31.31
6

ATOM
347
C
ALA
A
186
74.947
74.257
52.254
1.00
31.91
6

ATOM
348
O
ALA
A
186
73.943
73.655
51.866
1.00
32.67
8

ATOM
349
N
GLU
A
187
75.607
73.906
53.358
1.00
31.90
7

ATOM
350
CA
GLU
A
187
75.133
72.787
54.165
1.00
31.05
6

ATOM
351
CB
GLU
A
187
76.191
72.374
55.200
1.00
31.16
6

ATOM
352
CG
GLU
A
187
75.843
71.096
55.945
1.00
31.96
6

ATOM
353
CD
GLU
A
187
75.594
69.917
55.010
1.00
33.62
6

ATOM
354
OE1
GLU
A
187
76.476
69.612
54.175
1.00
32.31
8

ATOM
355
OE2
GLU
A
187
74.518
69.295
55.122
1.00
32.68
8

ATOM
356
C
GLU
A
187
73.825
73.162
54.872
1.00
31.33
6

ATOM
357
O
GLU
A
187
72.914
72.346
54.980
1.00
31.19
8

ATOM
358
N
VAL
A
188
73.731
74.402
55.343
1.00
31.77
7

ATOM
359
CA
VAL
A
188
72.517
74.865
56.020
1.00
31.65
6

ATOM
360
CB
VAL
A
188
72.678
76.322
56.520
1.00
32.04
6

ATOM
361
CG1
VAL
A
188
71.320
76.886
56.961
1.00
32.24
6

ATOM
362
CG2
VAL
A
188
73.669
76.366
57.671
1.00
30.03
6

ATOM
363
C
VAL
A
188
71.291
74.798
55.103
1.00
33.16
6

ATOM
364
O
VAL
A
188
70.210
74.406
55.530
1.00
34.73
8

ATOM
365
N
ALA
A
189
71.457
75.184
53.844
1.00
34.76
7

ATOM
366
CA
ALA
A
189
70.344
75.161
52.895
1.00
36.39
6

ATOM
367
CB
ALA
A
189
70.672
76.029
51.686
1.00
33.11
6

ATOM
368
C
ALA
A
189
70.041
73.745
52.438
1.00
37.88
6

ATOM
369
O
ALA
A
189
68.949
73.459
51.941
1.00
39.60
8

ATOM
370
N
SER
A
190
71.005
72.853
52.618
1.00
38.95
7

ATOM
371
CA
SER
A
190
70.847
71.474
52.177
1.00
39.35
6

ATOM
372
CB
SER
A
190
72.218
70.915
51.788
1.00
39.59
6

ATOM
373
OG
SER
A
190
72.109
69.590
51.311
1.00
40.87
8

ATOM
374
C
SER
A
190
70.174
70.525
53.165
1.00
39.40
6

ATOM
375
O
SER
A
190
69.494
69.580
52.761
1.00
39.50
8

ATOM
376
N
ARG
A
191
70.344
70.777
54.454
1.00
39.21
7

ATOM
377
CA
ARG
A
191
69.776
69.888
55.458
1.00
38.96
6

ATOM
378
CB
ARG
A
191
70.443
70.138
56.814
1.00
38.48
6

ATOM
379
CG
ARG
A
191
70.107
71.477
57.440
1.00
38.08
6

ATOM
380
CD
ARG
A
191
71.013
71.773
58.633
1.00
35.79
6

ATOM
381
NE
ARG
A
191
70.569
72.963
59.343
1.00
33.38
7

ATOM
382
CZ
ARG
A
191
71.342
73.711
60.120
1.00
33.32
6

ATOM
383
NH1
ARG
A
191
72.621
73.394
60.298
1.00
32.02
7

ATOM
384
NH2
ARG
A
191
70.833
74.783
60.716
1.00
30.46
7

ATOM
385
C
ARG
A
191
68.258
69.947
55.608
1.00
39.45
6

ATOM
386
O
ARG
A
191
67.636
71.006
55.476
1.00
39.71
8

ATOM
387
N
ASP
A
192
67.679
68.783
55.878
1.00
38.00
7

ATOM
388
CA
ASP
A
192
66.245
68.629
56.075
1.00
39.84
6

ATOM
389
CB
ASP
A
192
65.870
67.148
55.963
1.00
40.03
6

ATOM
390
CG
ASP
A
192
64.409
66.889
56.248
1.00
43.15
6

ATOM
391
OD1
ASP
A
192
63.555
67.343
55.457
1.00
45.87
8

ATOM
392
OD2
ASP
A
192
64.113
66.232
57.266
1.00
45.16
8

ATOM
393
C
ASP
A
192
65.891
69.152
57.467
1.00
40.43
6

ATOM
394
O
ASP
A
192
66.370
68.631
58.474
1.00
38.03
8

ATOM
395
N
PRO
A
193
65.044
70.189
57.541
1.00
41.55
7

ATOM
396
CD
PRO
A
193
64.320
70.847
56.441
1.00
42.01
6

ATOM
397
CA
PRO
A
193
64.656
70.756
58.836
1.00
40.65
6

ATOM
398
CB
PRO
A
193
63.666
71.858
58.453
1.00
41.29
6

ATOM
399
CG
PRO
A
193
63.107
71.385
57.148
1.00
43.85
6

ATOM
400
C
PRO
A
193
64.079
69.755
59.835
1.00
40.66
6

ATOM
401
O
PRO
A
193
64.408
69.802
61.025
1.00
39.99
8

ATOM
402
N
LYS
A
194
63.233
68.847
59.362
1.00
39.17
7

ATOM
403
CA
LYS
A
194
62.640
67.859
60.248
1.00
39.32
6

ATOM
404
CB
LYS
A
194
61.497
67.123
59.539
1.00
42.18
6

ATOM
405
CG
LYS
A
194
60.188
67.917
59.542
1.00
46.80
6

ATOM
406
CD
LYS
A
194
59.103
67.305
58.655
1.00
48.93
6

ATOM
407
CE
LYS
A
194
59.305
67.673
57.185
1.00
50.15
6

ATOM
408
NZ
LYS
A
194
58.293
67.047
56.289
1.00
49.54
7

ATOM
409
C
LYS
A
194
63.663
66.864
60.788
1.00
38.24
6

ATOM
410
O
LYS
A
194
63.715
66.626
61.998
1.00
38.44
8

ATOM
411
N
LEU
A
195
64.480
66.289
59.911
1.00
34.90
7

ATOM
412
CA
LEU
A
195
65.481
65.324
60.354
1.00
33.46
6

ATOM
413
CB
LEU
A
195
66.031
64.531
59.171
1.00
34.18
6

ATOM
414
CG
LEU
A
195
65.118
63.410
58.671
1.00
37.54
6

ATOM
415
CD1
LEU
A
195
65.680
62.817
57.387
1.00
38.35
6

ATOM
416
CD2
LEU
A
195
64.984
62.341
59.749
1.00
36.51
6

ATOM
417
C
LEU
A
195
66.631
65.968
61.114
1.00
30.93
6

ATOM
418
O
LEU
A
195
67.303
65.308
61.891
1.00
31.92
8

ATOM
419
N
TYR
A
196
66.861
67.254
60.892
1.00
30.29
7

ATOM
420
CA
TYR
A
196
67.938
67.938
61.585
1.00
30.25
6

ATOM
421
CB
TYR
A
196
68.242
69.280
60.920
1.00
28.95
6

ATOM
422
CG
TYR
A
196
69.341
70.064
61.619
1.00
30.60
6

ATOM
423
CD1
TYR
A
196
70.633
69.538
61.742
1.00
27.81
6

ATOM
424
CE1
TYR
A
196
71.649
70.252
62.383
1.00
25.05
6

ATOM
425
CD2
TYR
A
196
69.092
71.328
62.155
1.00
26.98
6

ATOM
426
CE2
TYR
A
196
70.103
72.054
62.797
1.00
26.28
6

ATOM
427
CZ
TYR
A
196
71.380
71.510
62.908
1.00
26.79
6

ATOM
428
OH
TYR
A
196
72.386
72.219
63.542
1.00
26.23
8

ATOM
429
C
TYR
A
196
67.504
68.168
63.025
1.00
31.75
6

ATOM
430
O
TYR
A
196
68.302
68.067
63.962
1.00
29.91
8

ATOM
431
N
ALA
A
197
66.216
68.457
63.185
1.00
31.94
7

ATOM
432
CA
ALA
A
197
65.631
68.725
64.495
1.00
32.73
6

ATOM
433
CB
ALA
A
197
64.210
69.303
64.318
1.00
30.99
6

ATOM
434
C
ALA
A
197
65.590
67.510
65.415
1.00
31.74
6

ATOM
435
O
ALA
A
197
65.821
67.627
66.620
1.00
30.59
8

ATOM
436
N
MET
A
198
65.306
66.342
64.851
1.00
31.75
7

ATOM
437
CA
MET
A
198
65.204
65.134
65.656
1.00
30.86
6

ATOM
438
CB
MET
A
198
63.992
64.321
65.194
1.00
35.44
6

ATOM
439
CG
MET
A
198
62.678
65.078
65.343
1.00
38.40
6

ATOM
440
SD
MET
A
198
61.238
64.104
64.876
1.00
41.71
16

ATOM
441
CE
MET
A
198
61.265
64.311
63.089
1.00
42.99
6

ATOM
442
C
MET
A
198
66.441
64.247
65.698
1.00
30.86
6

ATOM
443
O
MET
A
198
66.467
63.267
66.435
1.00
28.18
8

ATOM
444
N
HIS
A
199
67.454
64.593
64.905
1.00
31.12
7

ATOM
445
CA
HIS
A
199
68.723
63.858
64.842
1.00
31.16
6

ATOM
446
CB
HIS
A
199
69.744
64.500
65.795
1.00
31.34
6

ATOM
447
CG
HIS
A
199
69.302
64.525
67.224
1.00
32.13
6

ATOM
448
CD2
HIS
A
199
69.604
63.713
68.265
1.00
34.85
6

ATOM
449
ND1
HIS
A
199
68.393
65.443
67.707
1.00
33.92
7

ATOM
450
CE1
HIS
A
199
68.155
65.193
68.982
1.00
34.56
6

ATOM
451
NE2
HIS
A
199
68.875
64.148
69.345
1.00
33.68
7

ATOM
452
C
HIS
A
199
68.681
62.354
65.126
1.00
31.00
6

ATOM
453
O
HIS
A
199
69.395
61.858
66.005
1.00
32.05
8

ATOM
454
N
PRO
A
200
67.527
62.048
64.298
1.00
29.80
7

ATOM
455
CD
PRO
A
200
66.759
62.440
63.104
1.00
28.73
6

ATOM
456
CA
PRO
A
200
67.429
60.608
64.547
1.00
29.05
6

ATOM
457
CB
PRO
A
200
66.495
60.122
63.433
1.00
30.89
6

ATOM
458
CG
PRO
A
200
66.679
61.138
62.345
1.00
30.13
6

ATOM
459
C
PRO
A
200
68.797
59.926
64.502
1.00
30.31
6

ATOM
460
O
PRO
A
200
69.615
60.220
63.633
1.00
30.28
8

ATOM
461
N
TRP
A
201
69.054
59.028
65.445
1.00
32.21
7

ATOM
462
CA
TRP
A
201
70.336
58.329
65.476
1.00
33.69
6

ATOM
463
CB
TRP
A
201
70.875
58.230
66.910
1.00
34.08
6

ATOM
464
CG
TRP
A
201
72.292
57.711
66.993
1.00
37.06
6

ATOM
465
CD2
TRP
A
201
73.040
57.428
68.185
1.00
35.36
6

ATOM
466
CE2
TRP
A
201
74.314
56.971
67.782
1.00
37.70
6

ATOM
467
CE3
TRP
A
201
72.757
57.519
69.553
1.00
36.21
6

ATOM
468
CD1
TRP
A
201
73.126
57.420
65.943
1.00
37.66
6

ATOM
469
NE1
TRP
A
201
74.339
56.974
66.412
1.00
38.14
7

ATOM
470
CZ2
TRP
A
201
75.307
56.602
68.702
1.00
36.84
6

ATOM
471
CZ3
TRP
A
201
73.745
57.152
70.471
1.00
37.14
6

ATOM
472
CH2
TRP
A
201
75.003
56.700
70.038
1.00
37.10
6

ATOM
473
C
TRP
A
201
70.097
56.952
64.882
1.00
34.33
6

ATOM
474
O
TRP
A
201
69.510
56.080
65.517
1.00
33.11
8

ATOM
475
N
VAL
A
202
70.559
56.775
63.647
1.00
36.85
7

ATOM
476
CA
VAL
A
202
70.367
55.529
62.913
1.00
38.96
6

ATOM
477
CB
VAL
A
202
69.350
55.750
61.767
1.00
40.01
6

ATOM
478
CG1
VAL
A
202
69.085
54.449
61.033
1.00
43.41
6

ATOM
479
CG2
VAL
A
202
68.055
56.316
62.328
1.00
40.66
6

ATOM
480
C
VAL
A
202
71.664
54.993
62.314
1.00
39.12
6

ATOM
481
O
VAL
A
202
72.680
55.690
62.268
1.00
37.87
8

ATOM
482
N
THR
A
203
71.613
53.747
61.856
1.00
38.84
7

ATOM
483
CA
THR
A
203
72.754
53.082
61.239
1.00
40.24
6

ATOM
484
CB
THR
A
203
73.549
52.242
62.276
1.00
39.40
6

ATOM
485
OG1
THR
A
203
74.603
51.531
61.616
1.00
38.31
8

ATOM
486
CG2
THR
A
203
72.636
51.249
62.976
1.00
41.20
6

ATOM
487
C
THR
A
203
72.254
52.161
60.124
1.00
40.15
6

ATOM
488
O
THR
A
203
71.137
51.646
60.188
1.00
40.78
8

ATOM
489
N
SER
A
204
73.081
51.969
59.101
1.00
40.08
7

ATOM
490
CA
SER
A
204
72.728
51.110
57.972
1.00
41.48
6

ATOM
491
CB
SER
A
204
73.236
51.712
56.665
1.00
40.66
6

ATOM
492
OG
SER
A
204
72.486
52.859
56.328
1.00
46.94
8

ATOM
493
C
SER
A
204
73.317
49.722
58.133
1.00
39.55
6

ATOM
494
O
SER
A
204
73.119
48.857
57.285
1.00
41.01
8

ATOM
495
N
LYS
A
205
74.051
49.522
59.219
1.00
38.82
7

ATOM
496
CA
LYS
A
205
74.681
48.242
59.493
1.00
37.56
6

ATOM
497
CB
LYS
A
205
75.671
48.394
60.645
1.00
40.15
6

ATOM
498
CG
LYS
A
205
76.658
49.543
60.463
1.00
42.40
6

ATOM
499
CD
LYS
A
205
77.596
49.663
61.662
1.00
46.90
6

ATOM
500
CE
LYS
A
205
78.471
50.916
61.582
1.00
47.18
6

ATOM
501
NZ
LYS
A
205
77.679
52.178
61.696
1.00
46.85
7

ATOM
502
C
LYS
A
205
73.644
47.175
59.837
1.00
37.13
6

ATOM
503
O
LYS
A
205
72.578
47.474
60.389
1.00
32.51
8

ATOM
504
N
PRO
A
206
73.943
45.908
59.516
1.00
37.22
7

ATOM
505
CD
PRO
A
206
75.141
45.368
58.852
1.00
37.51
6

ATOM
506
CA
PRO
A
206
72.990
44.840
59.820
1.00
39.41
6

ATOM
507
CB
PRO
A
206
73.560
43.652
59.054
1.00
39.48
6

ATOM
508
CG
PRO
A
206
75.033
43.886
59.144
1.00
37.54
6

ATOM
509
C
PRO
A
206
72.915
44.587
61.319
1.00
40.78
6

ATOM
510
O
PRO
A
206
73.866
44.881
62.049
1.00
39.86
8

ATOM
511
N
LEU
A
207
71.782
44.063
61.777
1.00
42.43
7

ATOM
512
CA
LEU
A
207
71.614
43.759
63.192
1.00
44.83
6

ATOM
513
CB
LEU
A
207
70.167
43.360
63.503
1.00
45.74
6

ATOM
514
CG
LEU
A
207
69.444
43.977
64.712
1.00
46.64
6

ATOM
515
CD1
LEU
A
207
68.219
43.127
65.034
1.00
47.31
6

ATOM
516
CD2
LEU
A
207
70.355
44.039
65.923
1.00
46.33
6

ATOM
517
C
LEU
A
207
72.527
42.572
63.466
1.00
45.91
6

ATOM
518
O
LEU
A
207
72.424
41.536
62.805
1.00
44.13
8

ATOM
519
N
PRO
A
208
73.446
42.713
64.433
1.00
47.69
7

ATOM
520
CD
PRO
A
208
73.684
43.874
65.308
1.00
48.31
6

ATOM
521
CA
PRO
A
208
74.360
41.615
64.756
1.00
48.38
6

ATOM
522
CB
PRO
A
208
75.243
42.210
65.855
1.00
49.10
6

ATOM
523
CG
PRO
A
208
74.358
43.241
66.496
1.00
48.65
6

ATOM
524
C
PRO
A
208
73.626
40.352
65.202
1.00
49.69
6

ATOM
525
O
PRO
A
208
72.506
40.420
65.719
1.00
48.02
8

ATOM
526
N
GLU
A
209
74.263
39.203
64.989
1.00
51.42
7

ATOM
527
CA
GLU
A
209
73.683
37.918
65.359
1.00
54.40
6

ATOM
528
CB
GLU
A
209
74.666
36.787
65.045
1.00
56.31
6

ATOM
529
CG
GLU
A
209
74.951
36.592
63.562
1.00
59.24
6

ATOM
530
CD
GLU
A
209
75.847
35.394
63.293
1.00
60.98
6

ATOM
531
OE1
GLU
A
209
75.487
34.274
63.720
1.00
62.38
8

ATOM
532
OE2
GLU
A
209
76.908
35.571
62.655
1.00
61.16
8

ATOM
533
C
GLU
A
209
73.290
37.844
66.833
1.00
54.96
6

ATOM
534
O
GLU
A
209
72.205
37.368
67.170
1.00
54.11
8

ATOM
535
N
TYR
A
210
74.173
38.324
67.704
1.00
55.27
7

ATOM
536
CA
TYR
A
210
73.921
38.285
69.138
1.00
55.72
6

ATOM
537
CB
TYR
A
210
75.199
38.615
69.909
1.00
54.97
6

ATOM
538
CG
TYR
A
210
75.837
39.934
69.545
1.00
53.50
6

ATOM
539
CD1
TYR
A
210
75.246
41.146
69.902
1.00
52.23
6

ATOM
540
CE1
TYR
A
210
75.852
42.359
69.576
1.00
51.04
6

ATOM
541
CD2
TYR
A
210
77.043
39.968
68.852
1.00
52.93
6

ATOM
542
CE2
TYR
A
210
77.650
41.167
68.521
1.00
51.58
6

ATOM
543
CZ
TYR
A
210
77.054
42.356
68.885
1.00
50.20
6

ATOM
544
OH
TYR
A
210
77.670
43.537
68.547
1.00
49.63
8

ATOM
545
C
TYR
A
210
72.786
39.173
69.617
1.00
57.31
6

ATOM
546
O
TYR
A
210
72.507
39.227
70.812
1.00
58.22
8

ATOM
547
N
LEU
A
211
72.136
39.878
68.699
1.00
58.25
7

ATOM
548
CA
LEU
A
211
71.010
40.715
69.081
1.00
59.76
6

ATOM
549
CB
LEU
A
211
71.127
42.120
68.480
1.00
58.89
6

ATOM
550
CG
LEU
A
211
72.043
43.077
69.252
1.00
58.32
6

ATOM
551
CD1
LEU
A
211
71.811
44.503
68.782
1.00
59.00
6

ATOM
552
CD2
LEU
A
211
71.755
42.981
70.740
1.00
57.43
6

ATOM
553
C
LEU
A
211
69.705
40.055
68.650
1.00
61.58
6

ATOM
554
O
LEU
A
211
68.665
40.244
69.287
1.00
61.40
8

ATOM
555
N
TRP
A
212
69.797
39.276
67.573
1.00
63.39
7

ATOM
556
CA
TRP
A
212
68.622
38.564
67.087
1.00
65.26
6

ATOM
557
CB
TRP
A
212
68.908
37.881
65.748
1.00
64.31
6

ATOM
558
CG
TRP
A
212
68.828
38.786
64.552
1.00
63.93
6

ATOM
559
CD2
TRP
A
212
67.659
39.382
63.970
1.00
63.86
6

ATOM
560
CE2
TRP
A
212
68.080
40.100
62.829
1.00
63.73
6

ATOM
561
CE3
TRP
A
212
66.296
39.375
64.300
1.00
63.75
6

ATOM
562
CD1
TRP
A
212
69.879
39.162
63.767
1.00
63.25
6

ATOM
563
NE1
TRP
A
212
69.438
39.950
62.729
1.00
63.95
7

ATOM
564
CZ2
TRP
A
212
67.186
40.806
62.015
1.00
63.72
6

ATOM
565
CZ3
TRP
A
212
65.406
40.078
63.488
1.00
63.47
6

ATOM
566
CH2
TRP
A
212
65.857
40.783
62.359
1.00
63.40
6

ATOM
567
C
TRP
A
212
68.156
37.503
68.116
1.00
67.11
6

ATOM
568
O
TRP
A
212
66.974
37.411
68.406
1.00
67.04
8

ATOM
569
N
LYS
A
213
69.071
36.687
68.684
1.00
69.60
7

ATOM
570
CA
LYS
A
213
68.615
35.692
69.657
1.00
72.45
6

ATOM
571
CB
LYS
A
213
69.795
35.083
70.434
1.00
72.91
6

ATOM
572
CG
LYS
A
213
71.151
35.178
69.720
1.00
73.41
6

ATOM
573
CD
LYS
A
213
72.265
34.534
70.547
1.00
74.50
6

ATOM
574
CE
LYS
A
213
73.571
34.451
69.782
1.00
74.02
6

ATOM
575
NZ
LYS
A
213
74.610
33.685
70.527
1.00
74.26
7

ATOM
576
C
LYS
A
213
67.622
36.344
70.646
1.00
73.83
6

ATOM
577
O
LYS
A
213
67.038
35.716
71.535
1.00
74.79
8

ATOM
578
N
LYS
A
214
67.504
37.656
70.401
1.00
74.78
7

ATOM
579
CA
LYS
A
214
66.777
38.671
71.168
1.00
75.80
6

ATOM
580
CB
LYS
A
214
67.666
39.911
71.249
1.00
76.17
6

ATOM
581
CG
LYS
A
214
67.624
40.622
72.596
1.00
76.65
6

ATOM
582
CD
LYS
A
214
68.876
40.438
73.455
1.00
77.27
6

ATOM
583
CE
LYS
A
214
68.722
41.169
74.789
1.00
77.92
6

ATOM
584
NZ
LYS
A
214
69.856
42.099
75.032
1.00
77.36
7

ATOM
585
C
LYS
A
214
65.424
39.034
70.615
1.00
76.65
6

ATOM
586
O
LYS
A
214
64.431
39.088
71.336
1.00
76.72
8

ATOM
587
N
ILE
A
215
65.404
39.272
69.299
1.00
53.16
7

ATOM
588
CA
ILE
A
215
64.168
39.541
68.633
1.00
53.16
6

ATOM
589
CB
ILE
A
215
64.360
40.201
67.242
1.00
80.75
6

ATOM
590
CG2
ILE
A
215
63.026
40.546
66.618
1.00
81.62
6

ATOM
591
CG1
ILE
A
215
65.234
41.449
67.375
1.00
80.02
6

ATOM
592
CD1
ILE
A
215
64.621
42.693
66.755
1.00
53.16
6

ATOM
593
C
ILE
A
215
63.509
38.190
68.511
1.00
53.16
6

ATOM
594
O
ILE
A
215
64.121
37.253
68.018
1.00
53.16
8

ATOM
595
N
ALA
A
216
62.338
37.988
69.040
1.00
169.91
7

ATOM
596
CA
ALA
A
216
61.822
36.612
69.010
1.00
170.88
6

ATOM
597
CB
ALA
A
216
60.943
36.337
70.214
1.00
117.32
6

ATOM
598
C
ALA
A
216
61.069
36.378
67.730
1.00
171.23
6

ATOM
599
O
ALA
A
216
61.535
36.689
66.641
1.00
171.61
8

ATOM
600
N
ASN
A
217
59.879
35.833
67.882
1.00
91.06
7

ATOM
601
CA
ASN
A
217
59.083
35.804
66.679
1.00
90.58
6

ATOM
602
CB
ASN
A
217
57.590
35.479
66.957
1.00
96.28
6

ATOM
603
CG
ASN
A
217
57.130
34.159
66.328
1.00
96.73
6

ATOM
604
OD1
ASN
A
217
57.642
33.759
65.285
1.00
96.34
8

ATOM
605
ND2
ASN
A
217
56.163
33.497
66.963
1.00
97.05
7

ATOM
606
C
ASN
A
217
59.252
37.263
66.204
1.00
90.98
6

ATOM
607
O
ASN
A
217
59.471
38.146
67.033
1.00
91.44
8

ATOM
608
N
ASN
A
218
59.175
37.549
64.915
1.00
53.16
7

ATOM
609
CA
ASN
A
218
59.400
38.896
64.425
1.00
53.16
6

ATOM
610
CB
ASN
A
218
58.601
39.086
63.147
1.00
92.18
6

ATOM
611
CG
ASN
A
218
59.490
39.810
62.161
1.00
92.63
6

ATOM
612
OD1
ASN
A
218
59.313
41.001
61.880
1.00
94.15
8

ATOM
613
ND2
ASN
A
218
60.460
39.089
61.616
1.00
93.35
7

ATOM
614
C
ASN
A
218
59.165
40.079
65.362
1.00
53.16
6

ATOM
615
O
ASN
A
218
59.884
41.074
65.328
1.00
53.16
8

ATOM
616
N
CYS
A
219
58.144
39.953
66.190
1.00
70.98
7

ATOM
617
CA
CYS
A
219
57.667
40.983
67.144
1.00
70.17
6

ATOM
618
CB
CYS
A
219
56.550
40.386
68.019
1.00
132.50
6

ATOM
619
SG
CYS
A
219
57.144
39.614
69.557
1.00
138.89
16

ATOM
620
C
CYS
A
219
58.679
41.623
68.105
1.00
68.14
6

ATOM
621
O
CYS
A
219
59.373
40.961
68.866
1.00
67.32
8

ATOM
622
N
ILE
A
220
58.709
42.949
68.042
1.00
53.16
7

ATOM
623
CA
ILE
A
220
59.562
43.695
69.014
1.00
53.16
6

ATOM
624
CB
ILE
A
220
60.555
44.678
68.343
1.00
53.16
6

ATOM
625
CG2
ILE
A
220
61.212
45.590
69.370
1.00
53.16
6

ATOM
626
CG1
ILE
A
220
61.621
43.904
67.577
1.00
53.16
6

ATOM
627
CD1
ILE
A
220
62.779
44.756
67.102
1.00
53.16
6

ATOM
628
C
ILE
A
220
58.660
44.470
69.915
1.00
53.16
6

ATOM
629
O
ILE
A
220
57.905
45.331
69.472
1.00
53.16
8

ATOM
630
N
PHE
A
221
58.777
44.312
71.214
1.00
53.16
7

ATOM
631
CA
PHE
A
221
57.907
45.054
72.121
1.00
53.16
6

ATOM
632
CB
PHE
A
221
57.840
44.180
73.398
1.00
124.59
6

ATOM
633
CG
PHE
A
221
57.154
42.817
73.251
1.00
126.22
6

ATOM
634
CD1
PHE
A
221
55.807
42.771
72.864
1.00
127.67
6

ATOM
635
CD2
PHE
A
221
57.792
41.616
73.511
1.00
126.30
6

ATOM
636
CE1
PHE
A
221
55.134
41.579
72.769
1.00
128.32
6

ATOM
637
CE2
PHE
A
221
57.125
40.411
73.421
1.00
126.64
6

ATOM
638
CZ
PHE
A
221
55.780
40.407
73.062
1.00
126.98
6

ATOM
639
C
PHE
A
221
58.270
46.582
72.404
1.00
53.16
6

ATOM
640
O
PHE
A
221
59.406
46.877
72.751
1.00
53.16
8

ATOM
641
N
ILE
A
222
57.296
47.537
72.275
1.00
64.18
7

ATOM
642
CA
ILE
A
222
57.527
48.977
72.591
1.00
63.35
6

ATOM
643
CB
ILE
A
222
57.687
49.872
71.360
1.00
62.62
6

ATOM
644
CG2
ILE
A
222
57.824
51.334
71.762
1.00
63.22
6

ATOM
645
CG1
ILE
A
222
58.895
49.449
70.528
1.00
63.17
6

ATOM
646
CD1
ILE
A
222
59.350
50.496
69.533
1.00
63.67
6

ATOM
647
C
ILE
A
222
56.389
49.591
73.382
1.00
63.29
6

ATOM
648
O
ILE
A
222
55.250
49.597
72.942
1.00
63.66
8

ATOM
649
N
LYS
A
223
56.724
50.106
74.566
1.00
62.68
7

ATOM
650
CA
LYS
A
223
55.767
50.701
75.477
1.00
61.51
6

ATOM
651
C
LYS
A
223
55.561
52.184
75.171
1.00
61.43
6

ATOM
652
O
LYS
A
223
56.486
52.986
75.271
1.00
60.49
8

ATOM
653
CB
LYS
A
223
56.191
50.472
76.934
1.00
61.52
6

ATOM
654
CG
LYS
A
223
56.257
49.000
77.312
1.00
20.00
6

ATOM
655
CD
LYS
A
223
56.630
48.818
78.776
1.00
20.00
6

ATOM
656
CE
LYS
A
223
56.336
47.411
79.256
1.00
20.00
6

ATOM
657
NZ
LYS
A
223
56.692
47.216
80.692
1.00
20.00
7

ATOM
658
N
ILE
A
224
54.343
52.475
74.785
1.00
61.21
7

ATOM
659
CA
ILE
A
224
53.980
53.836
74.483
1.00
61.68
6

ATOM
660
CB
ILE
A
224
53.124
53.900
73.226
1.00
61.28
6

ATOM
661
CG2
ILE
A
224
52.807
55.328
72.841
1.00
60.55
6

ATOM
662
CG1
ILE
A
224
53.843
53.185
72.098
1.00
61.68
6

ATOM
663
CD1
ILE
A
224
53.077
53.192
70.790
1.00
61.94
6

ATOM
664
C
ILE
A
224
53.302
54.497
75.675
1.00
62.84
6

ATOM
665
O
ILE
A
224
52.370
53.959
76.259
1.00
63.59
8

ATOM
666
N
HIS
A
225
53.810
55.666
76.003
1.00
62.46
7

ATOM
667
CA
HIS
A
225
53.317
56.449
77.081
1.00
63.71
6

ATOM
668
CB
HIS
A
225
54.424
56.828
78.041
1.00
60.91
6

ATOM
669
CG
HIS
A
225
55.144
55.689
78.771
1.00
59.21
6

ATOM
670
CD2
HIS
A
225
55.295
55.498
80.107
1.00
58.46
6

ATOM
671
ND1
HIS
A
225
55.833
54.649
78.182
1.00
58.01
7

ATOM
672
CE1
HIS
A
225
56.345
53.866
79.121
1.00
56.19
6

ATOM
673
NE2
HIS
A
225
56.033
54.377
80.297
1.00
56.41
7

ATOM
674
C
HIS
A
225
52.915
57.789
76.571
1.00
65.64
6

ATOM
675
O
HIS
A
225
53.732
58.470
75.943
1.00
65.89
8

ATOM
676
N
ARG
A
226
51.711
58.180
76.825
1.00
68.03
7

ATOM
677
CA
ARG
A
226
51.375
59.527
76.547
1.00
70.15
6

ATOM
678
CB
ARG
A
226
49.902
59.709
76.234
1.00
70.72
6

ATOM
679
CG
ARG
A
226
49.451
61.148
76.148
1.00
71.54
6

ATOM
680
CD
ARG
A
226
50.433
61.894
75.294
1.00
72.11
6

ATOM
681
NE
ARG
A
226
50.061
63.273
75.164
1.00
72.14
7

ATOM
682
CZ
ARG
A
226
50.533
64.052
74.195
1.00
72.31
6

ATOM
683
NH1
ARG
A
226
51.372
63.557
73.295
1.00
71.85
7

ATOM
684
NH2
ARG
A
226
50.166
65.324
74.130
1.00
72.33
7

ATOM
685
C
ARG
A
226
51.695
60.103
77.866
1.00
71.32
6

ATOM
686
O
ARG
A
226
52.855
60.351
78.208
1.00
71.29
8

ATOM
687
N
SER
A
227
50.634
60.311
78.629
1.00
62.53
7

ATOM
688
CA
SER
A
227
50.974
60.710
79.967
1.00
64.13
6

ATOM
689
CB
SER
A
227
49.596
61.366
79.992
1.00
53.16
6

ATOM
690
OG
SER
A
227
49.340
61.994
81.234
1.00
53.16
8

ATOM
691
C
SER
A
227
51.142
59.742
81.096
1.00
64.53
6

ATOM
692
O
SER
A
227
52.147
59.037
81.220
1.00
66.11
8

ATOM
693
N
THR
A
228
50.127
59.706
81.913
1.00
121.38
7

ATOM
694
CA
THR
A
228
50.193
58.802
82.991
1.00
120.74
6

ATOM
695
CB
THR
A
228
49.150
59.125
84.047
1.00
92.83
6

ATOM
696
OG1
THR
A
228
49.792
59.477
85.275
1.00
92.58
8

ATOM
697
CG2
THR
A
228
48.231
57.926
84.258
1.00
92.58
6

ATOM
698
C
THR
A
228
49.976
57.402
82.439
1.00
120.59
6

ATOM
699
O
THR
A
228
50.293
56.402
83.079
1.00
120.30
8

ATOM
700
N
THR
A
229
49.425
57.343
81.229
1.00
84.64
7

ATOM
701
CA
THR
A
229
49.104
56.081
80.575
1.00
84.19
6

ATOM
702
CB
THR
A
229
47.948
56.271
79.580
1.00
81.94
6

ATOM
703
OG1
THR
A
229
46.819
56.838
80.259
1.00
82.50
8

ATOM
704
CG2
THR
A
229
47.538
54.941
78.972
1.00
81.21
6

ATOM
705
C
THR
A
229
50.289
55.447
79.844
1.00
83.50
6

ATOM
706
O
THR
A
229
51.187
56.137
79.371
1.00
83.04
8

ATOM
707
N
SER
A
230
50.262
54.123
79.754
1.00
53.16
7

ATOM
708
CA
SER
A
230
51.310
53.346
79.101
1.00
53.16
6

ATOM
709
CB
SER
A
230
52.357
52.922
80.140
1.00
53.16
6

ATOM
710
OG
SER
A
230
52.750
51.562
79.994
1.00
53.16
8

ATOM
711
C
SER
A
230
50.691
52.107
78.454
1.00
53.16
6

ATOM
712
O
SER
A
230
49.986
51.341
79.113
1.00
53.16
8

ATOM
713
N
GLN
A
231
50.946
51.916
77.162
1.00
53.16
7

ATOM
714
CA
GLN
A
231
50.414
50.765
76.438
1.00
53.16
6

ATOM
715
CB
GLN
A
231
49.521
51.221
75.281
1.00
53.16
6

ATOM
716
CG
GLN
A
231
48.241
51.912
75.690
1.00
53.16
6

ATOM
717
CD
GLN
A
231
47.446
51.115
76.708
1.00
53.16
6

ATOM
718
OE1
GLN
A
231
47.753
51.139
77.897
1.00
53.16
8

ATOM
719
NE2
GLN
A
231
46.425
50.402
76.245
1.00
53.16
7

ATOM
720
C
GLN
A
231
51.554
49.920
75.879
1.00
53.16
6

ATOM
721
O
GLN
A
231
52.649
50.428
75.659
1.00
53.16
8

ATOM
722
N
THR
A
232
51.295
48.634
75.651
1.00
53.16
7

ATOM
723
CA
THR
A
232
52.299
47.740
75.091
1.00
53.16
6

ATOM
724
CB
THR
A
232
52.481
46.480
75.928
1.00
53.16
6

ATOM
725
OG1
THR
A
232
53.037
46.821
77.202
1.00
53.16
8

ATOM
726
CG2
THR
A
232
53.408
45.493
75.220
1.00
53.16
6

ATOM
727
C
THR
A
232
51.875
47.300
73.701
1.00
53.16
6

ATOM
728
O
THR
A
232
50.908
46.556
73.552
1.00
53.16
8

ATOM
729
N
ILE
A
233
52.603
47.753
72.688
1.00
53.16
7

ATOM
730
CA
ILE
A
233
52.291
47.371
71.309
1.00
53.16
6

ATOM
731
CB
ILE
A
233
52.186
48.638
70.407
1.00
58.58
6

ATOM
732
CG2
ILE
A
233
51.945
48.248
68.965
1.00
59.33
6

ATOM
733
CG1
ILE
A
233
51.071
49.560
70.899
1.00
59.50
6

ATOM
734
CD1
ILE
A
233
51.041
50.904
70.208
1.00
53.16
6

ATOM
735
C
ILE
A
233
53.343
46.425
70.763
1.00
53.16
6

ATOM
736
O
ILE
A
233
54.537
46.696
70.812
1.00
53.16
8

ATOM
737
N
LYS
A
234
52.863
45.312
70.244
1.00
53.16
7

ATOM
738
CA
LYS
A
234
53.700
44.308
69.621
1.00
53.16
6

ATOM
739
CB
LYS
A
234
52.937
42.991
69.423
1.00
153.67
6

ATOM
740
CG
LYS
A
234
53.812
41.802
69.054
1.00
154.03
6

ATOM
741
CD
LYS
A
234
53.043
40.486
69.163
1.00
153.67
6

ATOM
742
CE
LYS
A
234
51.748
40.495
68.360
1.00
151.85
6

ATOM
743
NZ
LYS
A
234
50.929
39.268
68.584
1.00
148.73
7

ATOM
744
C
LYS
A
234
54.139
44.871
68.260
1.00
53.16
6

ATOM
745
O
LYS
A
234
53.341
44.959
67.332
1.00
53.16
8

ATOM
746
N
VAL
A
235
55.409
45.239
68.124
1.00
53.16
7

ATOM
747
CA
VAL
A
235
55.919
45.799
66.875
1.00
53.16
6

ATOM
748
CB
VAL
A
235
56.650
47.137
67.151
1.00
65.81
6

ATOM
749
CG1
VAL
A
235
57.350
47.641
65.897
1.00
66.09
6

ATOM
750
CG2
VAL
A
235
55.659
48.165
67.663
1.00
66.37
6

ATOM
751
C
VAL
A
235
56.867
44.827
66.163
1.00
53.16
6

ATOM
752
O
VAL
A
235
57.549
44.034
66.810
1.00
53.16
8

ATOM
753
N
SER
A
236
56.895
44.913
64.828
1.00
53.16
7

ATOM
754
CA
SER
A
236
57.790
44.092
63.963
1.00
53.16
6

ATOM
755
CB
SER
A
236
57.070
43.625
62.697
1.00
115.18
6

ATOM
756
OG
SER
A
236
57.927
42.848
61.879
1.00
113.12
8

ATOM
757
C
SER
A
236
59.047
44.874
63.630
1.00
53.16
6

ATOM
758
O
SER
A
236
58.964
46.085
63.480
1.00
53.16
8

ATOM
759
N
PRO
A
237
60.223
44.222
63.506
1.00
53.16
7

ATOM
760
CD
PRO
A
237
60.487
42.980
64.241
1.00
53.16
6

ATOM
761
CA
PRO
A
237
61.478
44.999
63.328
1.00
53.16
6

ATOM
762
CB
PRO
A
237
62.519
43.892
63.176
1.00
53.16
6

ATOM
763
CG
PRO
A
237
61.980
42.840
64.137
1.00
53.16
6

ATOM
764
C
PRO
A
237
61.363
46.153
62.358
1.00
53.16
6

ATOM
765
O
PRO
A
237
61.456
47.338
62.730
1.00
53.16
8

ATOM
766
N
ASP
A
238
61.164
45.795
61.122
1.00
100.58
7

ATOM
767
CA
ASP
A
238
61.080
46.782
60.063
1.00
102.15
6

ATOM
768
CB
ASP
A
238
61.036
46.079
58.742
1.00
155.58
6

ATOM
769
CG
ASP
A
238
61.774
44.779
58.877
1.00
157.20
6

ATOM
770
OD1
ASP
A
238
62.858
44.780
59.496
1.00
158.13
8

ATOM
771
OD2
ASP
A
238
61.278
43.759
58.352
1.00
156.13
8

ATOM
772
C
ASP
A
238
59.925
47.733
60.234
1.00
102.94
6

ATOM
773
O
ASP
A
238
59.843
48.719
59.502
1.00
101.97
8

ATOM
774
N
ASP
A
239
59.049
47.472
61.162
1.00
65.88
7

ATOM
775
CA
ASP
A
239
58.022
48.441
61.351
1.00
66.83
6

ATOM
776
CB
ASP
A
239
57.198
48.181
62.590
1.00
111.82
6

ATOM
777
CG
ASP
A
239
55.839
47.561
62.260
1.00
113.49
6

ATOM
778
OD1
ASP
A
239
55.168
48.042
61.313
1.00
115.54
8

ATOM
779
OD2
ASP
A
239
55.462
46.594
62.965
1.00
113.11
8

ATOM
780
C
ASP
A
239
58.750
49.788
61.364
1.00
67.46
6

ATOM
781
O
ASP
A
239
59.905
49.866
61.807
1.00
67.62
8

ATOM
782
N
THR
A
240
58.101
50.837
60.869
1.00
53.16
7

ATOM
783
CA
THR
A
240
58.733
52.143
60.709
1.00
53.16
6

ATOM
784
CB
THR
A
240
58.371
52.694
59.359
1.00
53.16
6

ATOM
785
OG1
THR
A
240
59.402
52.381
58.413
1.00
53.16
8

ATOM
786
CG2
THR
A
240
58.197
54.214
59.453
1.00
53.16
6

ATOM
787
C
THR
A
240
58.325
53.169
61.761
1.00
53.16
6

ATOM
788
O
THR
A
240
57.178
53.195
62.221
1.00
53.16
8

ATOM
789
N
PRO
A
241
59.293
54.026
62.161
1.00
74.34
7

ATOM
790
CD
PRO
A
241
60.562
53.484
62.624
1.00
164.98
6

ATOM
791
CA
PRO
A
241
58.925
55.110
63.095
1.00
74.73
6

ATOM
792
CB
PRO
A
241
60.232
55.793
63.407
1.00
165.88
6

ATOM
793
CG
PRO
A
241
61.155
54.605
63.438
1.00
165.59
6

ATOM
794
C
PRO
A
241
57.808
55.959
62.548
1.00
74.42
6

ATOM
795
O
PRO
A
241
57.985
57.166
62.367
1.00
74.77
8

ATOM
796
N
GLY
A
242
56.661
55.393
62.276
1.00
68.38
7

ATOM
797
CA
GLY
A
242
55.589
56.174
61.729
1.00
67.15
6

ATOM
798
C
GLY
A
242
54.524
55.190
61.371
1.00
66.64
6

ATOM
799
O
GLY
A
242
53.344
55.419
61.633
1.00
65.15
8

ATOM
800
N
ALA
A
243
54.948
54.089
60.762
1.00
86.81
7

ATOM
801
CA
ALA
A
243
54.034
53.020
60.440
1.00
86.33
6

ATOM
802
CB
ALA
A
243
54.733
51.967
59.623
1.00
149.66
6

ATOM
803
C
ALA
A
243
53.618
52.462
61.789
1.00
85.73
6

ATOM
804
O
ALA
A
243
52.541
51.893
61.932
1.00
85.52
8

ATOM
805
N
ILE
A
244
54.486
52.635
62.783
1.00
53.16
7

ATOM
806
CA
ILE
A
244
54.190
52.165
64.130
1.00
53.16
6

ATOM
807
CB
ILE
A
244
55.429
52.229
65.046
1.00
53.16
6

ATOM
808
CG2
ILE
A
244
55.010
52.083
66.510
1.00
53.16
6

ATOM
809
CG1
ILE
A
244
56.415
51.137
64.641
1.00
53.16
6

ATOM
810
CD1
ILE
A
244
57.621
51.015
65.545
1.00
53.16
6

ATOM
811
C
ILE
A
244
53.087
53.014
64.739
1.00
53.16
6

ATOM
812
O
ILE
A
244
52.226
52.498
65.445
1.00
53.16
8

ATOM
813
N
LEU
A
245
53.110
54.314
64.453
1.00
78.57
7

ATOM
814
CA
LEU
A
245
52.093
55.221
64.973
1.00
79.43
6

ATOM
815
CB
LEU
A
245
52.455
56.675
64.674
1.00
53.16
6

ATOM
816
CG
LEU
A
245
53.461
57.352
65.612
1.00
53.16
6

ATOM
817
CD1
LEU
A
245
53.857
58.706
65.043
1.00
53.16
6

ATOM
818
CD2
LEU
A
245
52.850
57.518
66.996
1.00
53.16
6

ATOM
819
C
LEU
A
245
50.733
54.911
64.379
1.00
80.99
6

ATOM
820
O
LEU
A
245
49.728
54.899
65.086
1.00
81.22
8

ATOM
821
N
GLN
A
246
50.705
54.658
63.074
1.00
53.16
7

ATOM
822
CA
GLN
A
246
49.441
54.343
62.420
1.00
53.16
6

ATOM
823
CB
GLN
A
246
49.652
54.030
60.941
1.00
53.88
6

ATOM
824
CG
GLN
A
246
49.815
55.280
60.086
1.00
54.99
6

ATOM
825
CD
GLN
A
246
49.986
54.971
58.611
1.00
56.11
6

ATOM
826
OE1
GLN
A
246
49.273
54.133
58.054
1.00
56.70
8

ATOM
827
NE2
GLN
A
246
50.927
55.656
57.966
1.00
55.61
7

ATOM
828
C
GLN
A
246
48.810
53.165
63.124
1.00
53.16
6

ATOM
829
O
GLN
A
246
47.637
53.218
63.498
1.00
53.16
8

ATOM
830
N
SER
A
247
49.604
52.119
63.323
1.00
53.16
7

ATOM
831
CA
SER
A
247
49.123
50.919
63.996
1.00
53.16
6

ATOM
832
CB
SER
A
247
50.215
49.840
64.022
1.00
114.03
6

ATOM
833
OG
SER
A
247
51.328
50.258
64.782
1.00
114.92
8

ATOM
834
C
SER
A
247
48.684
51.234
65.419
1.00
53.16
6

ATOM
835
O
SER
A
247
47.872
50.512
65.990
1.00
53.16
8

ATOM
836
N
PHE
A
248
49.204
52.322
65.981
1.00
53.16
7

ATOM
837
CA
PHE
A
248
48.845
52.698
67.347
1.00
53.16
6

ATOM
838
CB
PHE
A
248
50.040
53.328
68.067
1.00
53.16
6

ATOM
839
CG
PHE
A
248
49.689
53.730
69.474
1.00
53.16
6

ATOM
840
CD1
PHE
A
248
49.549
52.748
70.442
1.00
53.16
6

ATOM
841
CD2
PHE
A
248
49.470
55.057
69.819
1.00
53.16
6

ATOM
842
CE1
PHE
A
248
49.184
53.073
71.735
1.00
53.16
6

ATOM
843
CE2
PHE
A
248
49.103
55.394
71.113
1.00
53.16
6

ATOM
844
CZ
PHE
A
248
48.963
54.395
72.072
1.00
53.16
6

ATOM
845
C
PHE
A
248
47.688
53.688
67.405
1.00
53.16
6

ATOM
846
O
PHE
A
248
47.189
53.984
68.483
1.00
53.16
8

ATOM
847
N
PHE
A
249
47.245
54.182
66.290
1.00
60.39
7

ATOM
848
CA
PHE
A
249
46.200
55.188
66.325
1.00
61.38
6

ATOM
849
CB
PHE
A
249
46.528
56.257
65.372
1.00
53.16
6

ATOM
850
CG
PHE
A
249
47.073
57.342
66.161
1.00
53.16
6

ATOM
851
CD1
PHE
A
249
47.840
58.306
65.526
1.00
53.16
6

ATOM
852
CD2
PHE
A
249
46.826
57.411
67.525
1.00
53.16
6

ATOM
853
CE1
PHE
A
249
48.379
59.322
66.238
1.00
53.16
6

ATOM
854
CE2
PHE
A
249
47.359
58.452
68.242
1.00
53.16
6

ATOM
855
CZ
PHE
A
249
48.149
59.407
67.600
1.00
53.16
6

ATOM
856
C
PHE
A
249
44.902
54.655
65.961
1.00
62.53
6

ATOM
857
O
PHE
A
249
43.835
55.234
66.208
1.00
63.10
8

ATOM
858
N
THR
A
250
44.996
53.506
65.358
1.00
53.16
7

ATOM
859
CA
THR
A
250
43.840
52.787
64.960
1.00
53.16
6

ATOM
860
CB
THR
A
250
44.154
51.844
63.817
1.00
158.58
6

ATOM
861
OG1
THR
A
250
45.165
50.916
64.236
1.00
159.30
8

ATOM
862
CG2
THR
A
250
44.625
52.621
62.592
1.00
158.25
6

ATOM
863
C
THR
A
250
43.356
52.062
66.189
1.00
53.16
6

ATOM
864
O
THR
A
250
42.141
51.945
66.436
1.00
53.16
8

ATOM
865
N
LYS
A
251
44.295
51.571
66.956
1.00
180.93
7

ATOM
866
CA
LYS
A
251
43.885
50.880
68.154
1.00
181.15
6

ATOM
867
CB
LYS
A
251
45.071
50.171
68.811
1.00
108.05
6

ATOM
868
CG
LYS
A
251
44.676
49.099
69.815
1.00
107.68
6

ATOM
869
CD
LYS
A
251
44.075
47.885
69.121
1.00
107.38
6

ATOM
870
CE
LYS
A
251
43.240
47.056
70.083
1.00
108.75
6

ATOM
871
NZ
LYS
A
251
43.397
45.596
69.838
1.00
108.71
7

ATOM
872
C
LYS
A
251
43.280
51.868
69.129
1.00
181.42
6

ATOM
873
O
LYS
A
251
42.121
51.777
69.552
1.00
182.21
8

ATOM
874
N
MET
A
252
44.108
52.817
69.466
1.00
87.91
7

ATOM
875
CA
MET
A
252
43.717
53.881
70.330
1.00
87.58
6

ATOM
876
CB
MET
A
252
44.960
54.609
70.833
1.00
67.67
6

ATOM
877
CG
MET
A
252
45.206
54.465
72.328
1.00
68.16
6

ATOM
878
SD
MET
A
252
45.636
52.774
72.808
1.00
70.52
16

ATOM
879
CE
MET
A
252
44.066
52.189
73.452
1.00
67.73
6

ATOM
880
C
MET
A
252
42.819
54.868
69.599
1.00
87.42
6

ATOM
881
O
MET
A
252
42.812
56.054
69.912
1.00
87.91
8

ATOM
882
N
ALA
A
253
42.053
54.379
68.635
1.00
172.74
7

ATOM
883
CA
ALA
A
253
41.171
55.251
67.875
1.00
172.74
6

ATOM
884
CB
ALA
A
253
40.640
54.551
66.631
1.00
123.46
6

ATOM
885
C
ALA
A
253
40.012
55.738
68.728
1.00
172.74
6

ATOM
886
O
ALA
A
253
39.680
56.919
68.731
1.00
172.74
8

ATOM
887
N
LYS
A
254
39.399
54.811
69.455
1.00
92.29
7

ATOM
888
CA
LYS
A
254
38.260
55.141
70.294
1.00
92.11
6

ATOM
889
CB
LYS
A
254
37.090
54.194
69.994
1.00
73.18
6

ATOM
890
CG
LYS
A
254
36.636
54.219
68.532
1.00
71.96
6

ATOM
891
CD
LYS
A
254
35.922
52.927
68.170
1.00
71.34
6

ATOM
892
CE
LYS
A
254
34.725
52.690
69.072
1.00
71.22
6

ATOM
893
NZ
LYS
A
254
34.107
51.358
68.821
1.00
70.34
7

ATOM
894
C
LYS
A
254
38.623
55.112
71.774
1.00
92.50
6

ATOM
895
O
LYS
A
254
37.756
54.993
72.643
1.00
92.80
8

ATOM
896
N
LYS
A
255
39.919
55.207
72.046
1.00
53.16
7

ATOM
897
CA
LYS
A
255
40.428
55.234
73.413
1.00
53.16
6

ATOM
898
CB
LYS
A
255
41.284
54.000
73.727
1.00
53.16
6

ATOM
899
CG
LYS
A
255
40.721
52.666
73.295
1.00
53.16
6

ATOM
900
CD
LYS
A
255
40.372
51.822
74.492
1.00
53.16
6

ATOM
901
CE
LYS
A
255
40.403
50.334
74.164
1.00
53.16
6

ATOM
902
NZ
LYS
A
255
41.787
49.779
74.221
1.00
53.16
7

ATOM
903
C
LYS
A
255
41.316
56.474
73.494
1.00
53.16
6

ATOM
904
O
LYS
A
255
42.066
56.651
74.455
1.00
53.16
8

ATOM
905
N
LYS
A
256
41.232
57.319
72.464
1.00
53.16
7

ATOM
906
CA
LYS
A
256
42.021
58.547
72.390
1.00
53.16
6

ATOM
907
CB
LYS
A
256
41.447
59.494
71.342
1.00
53.16
6

ATOM
908
CG
LYS
A
256
41.676
59.068
69.910
1.00
53.16
6

ATOM
909
CD
LYS
A
256
43.109
59.304
69.470
1.00
53.16
6

ATOM
910
CE
LYS
A
256
43.177
60.341
68.339
1.00
53.16
6

ATOM
911
NZ
LYS
A
256
42.430
59.965
67.094
1.00
53.16
7

ATOM
912
C
LYS
A
256
42.037
59.252
73.723
1.00
53.16
6

ATOM
913
O
LYS
A
256
43.026
59.878
74.095
1.00
53.16
8

ATOM
914
N
SER
A
257
40.927
59.175
74.443
1.00
53.16
7

ATOM
915
CA
SER
A
257
40.866
59.809
75.739
1.00
53.16
6

ATOM
916
CB
SER
A
257
39.502
59.580
76.379
1.00
53.16
6

ATOM
917
OG
SER
A
257
39.479
60.095
77.695
1.00
53.16
8

ATOM
918
C
SER
A
257
41.961
59.174
76.583
1.00
53.16
6

ATOM
919
O
SER
A
257
42.863
59.859
77.046
1.00
53.16
8

ATOM
920
N
LEU
A
258
41.889
57.858
76.743
1.00
53.16
7

ATOM
921
CA
LEU
A
258
42.867
57.115
77.524
1.00
53.16
6

ATOM
922
CB
LEU
A
258
42.796
55.635
77.165
1.00
53.16
6

ATOM
923
CG
LEU
A
258
41.960
54.814
78.139
1.00
53.16
6

ATOM
924
CD1
LEU
A
258
41.899
53.379
77.679
1.00
53.16
6

ATOM
925
CD2
LEU
A
258
42.572
54.923
79.527
1.00
53.16
6

ATOM
926
C
LEU
A
258
44.312
57.600
77.413
1.00
53.16
6

ATOM
927
O
LEU
A
258
45.032
57.613
78.412
1.00
53.16
8

ATOM
928
N
MET
A
259
44.743
57.980
76.211
1.00
70.41
7

ATOM
929
CA
MET
A
259
46.114
58.459
76.000
1.00
70.41
6

ATOM
930
CB
MET
A
259
46.663
57.947
74.657
1.00
53.16
6

ATOM
931
CG
MET
A
259
46.826
56.423
74.575
1.00
53.16
6

ATOM
932
SD
MET
A
259
47.979
55.757
75.793
1.00
53.16
16

ATOM
933
CE
MET
A
259
49.500
55.743
74.845
1.00
53.16
6

ATOM
934
C
MET
A
259
46.190
59.972
76.048
1.00
70.41
6

ATOM
935
O
MET
A
259
47.024
60.575
75.385
1.00
70.41
8

ATOM
936
N
ASP
A
260
45.315
60.576
76.838
1.00
53.16
7

ATOM
937
CA
ASP
A
260
45.276
62.020
76.986
1.00
53.16
6

ATOM
938
CB
ASP
A
260
46.281
62.462
78.056
1.00
86.22
6

ATOM
939
CG
ASP
A
260
46.150
63.927
78.406
1.00
86.22
6

ATOM
940
OD1
ASP
A
260
45.017
64.363
78.687
1.00
86.22
8

ATOM
941
OD2
ASP
A
260
47.169
64.647
78.404
1.00
86.22
8

ATOM
942
C
ASP
A
260
45.535
62.779
75.672
1.00
53.16
6

ATOM
943
O
ASP
A
260
46.038
63.890
75.670
1.00
53.16
8

ATOM
944
N
ILE
A
261
45.179
62.123
74.563
1.00
70.71
7

ATOM
945
CA
ILE
A
261
45.388
62.669
73.212
1.00
70.71
6

ATOM
946
CB
ILE
A
261
45.736
61.519
72.246
1.00
58.77
6

ATOM
947
CG2
ILE
A
261
45.890
62.032
70.836
1.00
58.77
6

ATOM
948
CG1
ILE
A
261
47.024
60.811
72.696
1.00
58.77
6

ATOM
949
CD1
ILE
A
261
47.300
59.507
71.973
1.00
58.77
6

ATOM
950
C
ILE
A
261
44.182
63.383
72.642
1.00
70.71
6

ATOM
951
O
ILE
A
261
43.158
62.747
72.357
1.00
70.71
8

ATOM
952
N
PRO
A
262
44.248
64.720
72.472
1.00
94.39
7

ATOM
953
CD
PRO
A
262
44.677
65.532
73.619
1.00
89.42
6

ATOM
954
CA
PRO
A
262
43.062
65.465
71.858
1.00
94.39
6

ATOM
955
CB
PRO
A
262
43.490
66.901
71.981
1.00
89.42
6

ATOM
956
CG
PRO
A
262
44.189
66.916
73.321
1.00
89.42
6

ATOM
957
C
PRO
A
262
42.588
65.001
70.483
1.00
94.39
6

ATOM
958
O
PRO
A
262
43.405
64.811
69.590
1.00
94.39
8

ATOM
959
N
GLU
A
263
41.272
64.795
70.303
1.00
70.58
7

ATOM
960
CA
GLU
A
263
40.741
64.404
68.992
1.00
70.58
6

ATOM
961
CB
GLU
A
263
39.219
64.420
68.993
1.00
95.56
6

ATOM
962
CG
GLU
A
263
38.570
63.855
70.245
1.00
95.56
6

ATOM
963
CD
GLU
A
263
38.528
62.348
70.223
1.00
95.56
6

ATOM
964
OE1
GLU
A
263
38.663
61.758
69.139
1.00
95.56
8

ATOM
965
OE2
GLU
A
263
38.354
61.749
71.297
1.00
95.56
8

ATOM
966
C
GLU
A
263
41.266
65.369
67.929
1.00
70.58
6

ATOM
967
O
GLU
A
263
41.859
64.941
66.932
1.00
70.58
8

ATOM
968
N
SER
A
264
41.029
66.663
68.129
1.00
102.57
7

ATOM
969
CA
SER
A
264
41.445
67.661
67.174
1.00
102.57
6

ATOM
970
CB
SER
A
264
41.303
69.051
67.795
1.00
68.04
6

ATOM
971
OG
SER
A
264
39.960
69.498
67.733
1.00
68.04
8

ATOM
972
C
SER
A
264
42.878
67.424
66.667
1.00
102.57
6

ATOM
973
O
SER
A
264
43.139
67.552
65.481
1.00
102.57
8

ATOM
974
N
GLN
A
265
43.826
67.079
67.528
1.00
160.37
7

ATOM
975
CA
GLN
A
265
45.236
67.031
67.091
1.00
161.10
6

ATOM
976
CB
GLN
A
265
46.184
67.115
68.299
1.00
190.73
6

ATOM
977
CG
GLN
A
265
47.663
66.915
67.888
1.00
126.22
6

ATOM
978
CD
GLN
A
265
48.637
67.978
68.380
1.00
126.22
6

ATOM
979
OE1
GLN
A
265
48.932
68.964
67.691
1.00
126.22
8

ATOM
980
NE2
GLN
A
265
49.243
67.977
69.567
1.00
126.22
7

ATOM
981
C
GLN
A
265
45.717
65.885
66.174
1.00
161.75
6

ATOM
982
O
GLN
A
265
45.428
64.697
66.348
1.00
161.28
8

ATOM
983
N
SER
A
266
46.481
66.421
65.205
1.00
204.74
7

ATOM
984
CA
SER
A
266
47.205
65.811
64.110
1.00
204.74
6

ATOM
985
CB
SER
A
266
48.410
66.680
63.768
1.00
130.68
6

ATOM
986
OG
SER
A
266
49.254
66.836
64.896
1.00
130.37
8

ATOM
987
C
SER
A
266
47.728
64.448
64.391
1.00
204.74
6

ATOM
988
O
SER
A
266
48.889
64.327
64.802
1.00
204.74
8

ATOM
989
N
GLU
A
267
46.940
63.412
64.183
1.00
80.49
7

ATOM
990
CA
GLU
A
267
47.537
62.139
64.436
1.00
80.85
6

ATOM
991
CB
GLU
A
267
46.562
61.012
64.004
1.00
81.22
6

ATOM
992
CG
GLU
A
267
45.234
60.915
64.773
1.00
81.37
6

ATOM
993
CD
GLU
A
267
44.793
59.479
65.084
1.00
81.83
6

ATOM
994
OE1
GLU
A
267
44.955
58.587
64.219
1.00
81.59
8

ATOM
995
OE2
GLU
A
267
44.277
59.239
66.208
1.00
81.54
8

ATOM
996
C
GLU
A
267
48.899
62.037
63.721
1.00
80.71
6

ATOM
997
O
GLU
A
267
49.680
61.107
63.990
1.00
80.77
8

ATOM
998
N
GLN
A
268
49.193
62.974
62.817
1.00
80.11
7

ATOM
999
CA
GLN
A
268
50.456
62.978
62.072
1.00
79.66
6

ATOM
1000
CB
GLN
A
268
50.261
63.635
60.731
1.00
80.70
6

ATOM
1001
CG
GLN
A
268
49.596
62.784
59.694
1.00
81.84
6

ATOM
1002
CD
GLN
A
268
49.893
63.318
58.328
1.00
82.96
6

ATOM
1003
OE1
GLN
A
268
51.053
63.479
57.938
1.00
84.17
8

ATOM
1004
NE2
GLN
A
268
49.001
63.659
57.408
1.00
83.16
7

ATOM
1005
C
GLN
A
268
51.496
63.795
62.741
1.00
78.49
6

ATOM
1006
O
GLN
A
268
52.677
63.461
62.782
1.00
78.84
8

ATOM
1007
N
ASP
A
269
51.024
64.875
63.269
1.00
76.14
7

ATOM
1008
CA
ASP
A
269
51.981
65.681
63.862
1.00
73.43
6

ATOM
1009
CB
ASP
A
269
51.373
66.979
64.315
1.00
74.13
6

ATOM
1010
CG
ASP
A
269
52.417
68.048
64.076
1.00
74.74
6

ATOM
1011
OD1
ASP
A
269
53.629
67.729
64.220
1.00
74.86
8

ATOM
1012
OD2
ASP
A
269
52.048
69.201
63.751
1.00
74.73
8

ATOM
1013
C
ASP
A
269
52.729
64.999
64.974
1.00
71.26
6

ATOM
1014
O
ASP
A
269
53.845
65.386
65.272
1.00
71.35
8

ATOM
1015
N
PHE
A
270
52.132
63.998
65.610
1.00
68.36
7

ATOM
1016
CA
PHE
A
270
52.842
63.401
66.710
1.00
65.37
6

ATOM
1017
CB
PHE
A
270
51.947
62.398
67.453
1.00
66.66
6

ATOM
1018
CG
PHE
A
270
50.812
63.021
68.212
1.00
68.15
6

ATOM
1019
CD1
PHE
A
270
49.713
62.244
68.574
1.00
68.82
6

ATOM
1020
CD2
PHE
A
270
50.816
64.372
68.552
1.00
68.34
6

ATOM
1021
CE1
PHE
A
270
48.638
62.802
69.264
1.00
68.27
6

ATOM
1022
CE2
PHE
A
270
49.746
64.940
69.241
1.00
68.55
6

ATOM
1023
CZ
PHE
A
270
48.656
64.153
69.597
1.00
68.84
6

ATOM
1024
C
PHE
A
270
54.132
62.708
66.272
1.00
62.71
6

ATOM
1025
O
PHE
A
270
54.320
62.386
65.095
1.00
61.87
8

ATOM
1026
N
VAL
A
271
55.009
62.475
67.244
1.00
58.53
7

ATOM
1027
CA
VAL
A
271
56.285
61.808
67.014
1.00
53.95
6

ATOM
1028
CB
VAL
A
271
57.404
62.828
66.714
1.00
54.38
6

ATOM
1029
CG1
VAL
A
271
57.447
63.897
67.792
1.00
53.06
6

ATOM
1030
CG2
VAL
A
271
58.734
62.119
66.648
1.00
54.45
6

ATOM
1031
C
VAL
A
271
56.691
60.985
68.237
1.00
50.72
6

ATOM
1032
O
VAL
A
271
56.392
61.354
69.371
1.00
50.38
8

ATOM
1033
N
LEU
A
272
57.365
59.864
68.004
1.00
47.85
7

ATOM
1034
CA
LEU
A
272
57.819
59.017
69.101
1.00
44.84
6

ATOM
1035
CB
LEU
A
272
57.971
57.569
68.627
1.00
44.61
6

ATOM
1036
CG
LEU
A
272
56.682
56.807
68.306
1.00
43.88
6

ATOM
1037
CD1
LEU
A
272
57.017
55.504
67.615
1.00
43.57
6

ATOM
1038
CD2
LEU
A
272
55.897
56.555
69.588
1.00
42.73
6

ATOM
1039
C
LEU
A
272
59.158
59.523
69.647
1.00
44.26
6

ATOM
1040
O
LEU
A
272
60.149
59.607
68.917
1.00
41.38
8

ATOM
1041
N
ARG
A
273
59.176
59.873
70.928
1.00
42.50
7

ATOM
1042
CA
ARG
A
273
60.393
60.355
71.569
1.00
43.47
6

ATOM
1043
CB
ARG
A
273
60.203
61.791
72.053
1.00
44.05
6

ATOM
1044
CG
ARG
A
273
61.485
62.460
72.513
1.00
47.87
6

ATOM
1045
CD
ARG
A
273
61.175
63.590
73.463
1.00
50.27
6

ATOM
1046
NE
ARG
A
273
60.604
63.071
74.701
1.00
54.75
7

ATOM
1047
CZ
ARG
A
273
60.029
63.816
75.637
1.00
55.37
6

ATOM
1048
NH1
ARG
A
273
59.942
65.128
75.482
1.00
55.33
7

ATOM
1049
NH2
ARG
A
273
59.540
63.243
76.728
1.00
56.47
7

ATOM
1050
C
ARG
A
273
60.709
59.457
72.758
1.00
42.89
6

ATOM
1051
O
ARG
A
273
59.823
59.123
73.539
1.00
44.55
8

ATOM
1052
N
VAL
A
274
61.970
59.090
72.859
1.00
42.34
7

ATOM
1053
CA
VAL
A
274
62.418
58.232
73.932
1.00
41.88
6

ATOM
1054
CB
VAL
A
274
63.895
57.879
73.869
1.00
41.66
6

ATOM
1055
CG1
VAL
A
274
64.286
57.021
75.053
1.00
40.47
6

ATOM
1056
CG2
VAL
A
274
64.225
57.170
72.573
1.00
39.63
6

ATOM
1057
C
VAL
A
274
62.157
58.910
75.244
1.00
43.05
6

ATOM
1058
O
VAL
A
274
62.500
60.079
75.449
1.00
43.12
8

ATOM
1059
N
CYS
A
275
61.540
58.168
76.159
1.00
42.16
7

ATOM
1060
CA
CYS
A
275
61.182
58.697
77.478
1.00
42.64
6

ATOM
1061
CB
CYS
A
275
60.332
57.677
78.224
1.00
44.30
6

ATOM
1062
SG
CYS
A
275
58.933
57.020
77.262
1.00
47.39
16

ATOM
1063
C
CYS
A
275
62.418
59.149
78.325
1.00
40.81
6

ATOM
1064
O
CYS
A
275
63.347
58.390
78.563
1.00
39.56
8

ATOM
1065
N
GLY
A
276
62.377
60.401
78.749
1.00
40.36
7

ATOM
1066
CA
GLY
A
276
63.420
61.007
79.575
1.00
39.95
6

ATOM
1067
C
GLY
A
276
64.673
61.357
78.792
1.00
40.02
6

ATOM
1068
O
GLY
A
276
65.709
61.648
79.382
1.00
39.08
8

ATOM
1069
N
ARG
A
277
64.616
61.337
77.466
1.00
39.68
7

ATOM
1070
CA
ARG
A
277
65.768
61.654
76.630
1.00
39.22
6

ATOM
1071
CB
ARG
A
277
66.454
60.371
76.160
1.00
38.38
6

ATOM
1072
CG
ARG
A
277
67.282
59.681
77.234
1.00
40.38
6

ATOM
1073
CD
ARG
A
277
68.093
58.554
76.625
1.00
40.52
6

ATOM
1074
NE
ARG
A
277
69.370
58.361
77.304
1.00
40.00
7

ATOM
1075
CZ
ARG
A
277
70.483
59.028
77.012
1.00
41.64
6

ATOM
1076
NH1
ARG
A
277
70.488
59.932
76.042
1.00
40.07
7

ATOM
1077
NH2
ARG
A
277
71.591
58.807
77.708
1.00
40.48
7

ATOM
1078
C
ARG
A
277
65.366
62.435
75.411
1.00
38.17
6

ATOM
1079
O
ARG
A
277
64.262
62.246
74.878
1.00
38.28
8

ATOM
1080
N
ASP
A
278
66.226
63.283
74.952
1.00
37.36
7

ATOM
1081
CA
ASP
A
278
65.881
63.981
73.768
1.00
36.42
6

ATOM
1082
CB
ASP
A
278
66.308
65.420
73.858
1.00
39.00
6

ATOM
1083
CG
ASP
A
278
65.410
66.155
74.818
1.00
42.30
6

ATOM
1084
OD1
ASP
A
278
64.339
65.620
75.192
1.00
44.85
8

ATOM
1085
OD2
ASP
A
278
65.766
67.290
75.194
1.00
46.12
8

ATOM
1086
C
ASP
A
278
66.468
63.275
72.568
1.00
35.36
6

ATOM
1087
O
ASP
A
278
67.387
63.766
71.923
1.00
34.32
8

ATOM
1088
N
GLU
A
279
65.916
62.091
72.305
1.00
34.50
7

ATOM
1089
CA
GLU
A
279
66.262
61.216
71.206
1.00
34.76
6

ATOM
1090
CB
GLU
A
279
66.870
59.893
71.722
1.00
33.94
6

ATOM
1091
CG
GLU
A
279
68.073
59.342
70.977
1.00
37.49
6

ATOM
1092
CD
GLU
A
279
68.351
60.086
69.691
1.00
40.49
6

ATOM
1093
OE1
GLU
A
279
67.717
59.750
68.662
1.00
38.56
8

ATOM
1094
OE2
GLU
A
279
69.197
61.004
69.699
1.00
41.09
8

ATOM
1095
C
GLU
A
279
64.968
60.917
70.485
1.00
34.06
6

ATOM
1096
O
GLU
A
279
63.935
60.673
71.128
1.00
33.71
8

ATOM
1097
N
TYR
A
280
64.976
60.942
69.181
1.00
33.18
7

ATOM
1098
CA
TYR
A
280
63.713
60.696
68.473
1.00
33.28
6

ATOM
1099
CB
TYR
A
280
63.303
61.944
67.676
1.00
32.81
6

ATOM
1100
CG
TYR
A
280
62.972
63.145
68.511
1.00
32.69
6

ATOM
1101
CD1
TYR
A
280
63.947
64.038
68.946
1.00
33.03
6

ATOM
1102
CE1
TYR
A
280
63.613
65.154
69.708
1.00
33.47
6

ATOM
1103
CD2
TYR
A
280
61.648
63.394
68.865
1.00
34.08
6

ATOM
1104
CE2
TYR
A
280
61.299
64.507
69.631
1.00
33.65
6

ATOM
1105
CZ
TYR
A
280
62.282
65.383
70.046
1.00
33.08
6

ATOM
1106
OH
TYR
A
280
61.939
66.497
70.779
1.00
31.24
8

ATOM
1107
C
TYR
A
280
63.814
59.540
67.488
1.00
34.74
6

ATOM
1108
O
TYR
A
280
64.790
59.413
66.749
1.00
33.01
8

ATOM
1109
N
LEU
A
281
62.781
58.708
67.476
1.00
36.65
7

ATOM
1110
CA
LEU
A
281
62.699
57.578
66.561
1.00
39.88
6

ATOM
1111
CB
LEU
A
281
62.079
56.369
67.273
1.00
39.41
6

ATOM
1112
CG
LEU
A
281
62.991
55.495
68.144
1.00
40.83
6

ATOM
1113
CD1
LEU
A
281
63.950
56.356
68.937
1.00
39.99
6

ATOM
1114
CD2
LEU
A
281
62.137
54.619
69.065
1.00
39.72
6

ATOM
1115
C
LEU
A
281
61.796
58.045
65.420
1.00
40.27
6

ATOM
1116
O
LEU
A
281
60.581
57.865
65.475
1.00
42.08
8

ATOM
1117
N
VAL
A
282
62.394
58.673
64.409
1.00
42.06
7

ATOM
1118
CA
VAL
A
282
61.658
59.195
63.253
1.00
42.12
6

ATOM
1119
CB
VAL
A
282
61.428
60.722
63.353
1.00
42.25
6

ATOM
1120
CG1
VAL
A
282
60.639
61.046
64.575
1.00
42.55
6

ATOM
1121
CG2
VAL
A
282
62.767
61.458
63.379
1.00
40.56
6

ATOM
1122
C
VAL
A
282
62.413
58.958
61.955
1.00
43.62
6

ATOM
1123
O
VAL
A
282
63.556
58.503
61.966
1.00
45.05
8

ATOM
1124
N
GLY
A
283
61.768
59.295
60.840
1.00
44.62
7

ATOM
1125
CA
GLY
A
283
62.377
59.122
59.533
1.00
44.64
6

ATOM
1126
C
GLY
A
283
62.015
57.793
58.905
1.00
45.32
6

ATOM
1127
O
GLY
A
283
61.517
56.898
59.589
1.00
44.71
8

ATOM
1128
N
GLU
A
284
62.254
57.669
57.599
1.00
46.10
7

ATOM
1129
CA
GLU
A
284
61.971
56.430
56.866
1.00
47.03
6

ATOM
1130
CB
GLU
A
284
61.955
56.683
55.354
1.00
49.05
6

ATOM
1131
CG
GLU
A
284
60.899
57.658
54.873
1.00
51.36
6

ATOM
1132
CD
GLU
A
284
59.524
57.321
55.402
1.00
54.24
6

ATOM
1133
OE1
GLU
A
284
59.141
56.130
55.358
1.00
56.01
8

ATOM
1134
OE2
GLU
A
284
58.824
58.249
55.860
1.00
54.92
8

ATOM
1135
C
GLU
A
284
63.064
55.413
57.180
1.00
46.09
6

ATOM
1136
O
GLU
A
284
63.938
55.154
56.352
1.00
45.83
8

ATOM
1137
N
THR
A
285
63.011
54.841
58.376
1.00
44.86
7

ATOM
1138
CA
THR
A
285
64.015
53.872
58.800
1.00
43.90
6

ATOM
1139
CB
THR
A
285
65.075
54.526
59.712
1.00
41.58
6

ATOM
1140
OG1
THR
A
285
65.645
55.663
59.062
1.00
40.03
8

ATOM
1141
CG2
THR
A
285
66.160
53.503
60.046
1.00
41.20
6

ATOM
1142
C
THR
A
285
63.402
52.744
59.609
1.00
43.48
6

ATOM
1143
O
THR
A
285
62.503
52.965
60.416
1.00
43.85
8

ATOM
1144
N
PRO
A
286
63.915
51.545
59.376
1.00
44.37
7

ATOM
1145
CD
PRO
A
286
63.948
51.035
58.017
1.00
42.72
6

ATOM
1146
CA
PRO
A
286
63.478
50.406
60.228
1.00
45.32
6

ATOM
1147
CB
PRO
A
286
64.215
49.225
59.621
1.00
44.93
6

ATOM
1148
CG
PRO
A
286
64.145
49.557
58.161
1.00
43.50
6

ATOM
1149
C
PRO
A
286
63.692
50.628
61.703
1.00
46.39
6

ATOM
1150
O
PRO
A
286
64.668
51.291
62.078
1.00
46.08
8

ATOM
1151
N
ILE
A
287
62.843
50.114
62.578
1.00
45.93
7

ATOM
1152
CA
ILE
A
287
63.083
50.352
63.996
1.00
46.28
6

ATOM
1153
CB
ILE
A
287
61.917
49.846
64.865
1.00
48.30
6

ATOM
1154
CG2
ILE
A
287
61.816
48.330
64.790
1.00
50.48
6

ATOM
1155
CG1
ILE
A
287
62.091
50.310
66.313
1.00
49.83
6

ATOM
1156
CD1
ILE
A
287
60.884
50.051
67.187
1.00
53.01
6

ATOM
1157
C
ILE
A
287
64.371
49.685
64.462
1.00
44.46
6

ATOM
1158
O
ILE
A
287
65.080
50.222
65.302
1.00
44.38
8

ATOM
1159
N
LYS
A
288
64.652
48.506
63.918
1.00
42.78
7

ATOM
1160
CA
LYS
A
288
65.853
47.778
64.305
1.00
41.72
6

ATOM
1161
CB
LYS
A
288
65.871
46.396
63.660
1.00
41.81
6

ATOM
1162
CG
LYS
A
288
65.721
46.417
62.153
1.00
41.25
6

ATOM
1163
CD
LYS
A
288
65.938
45.027
61.571
1.00
43.20
6

ATOM
1164
CE
LYS
A
288
65.909
45.062
60.049
1.00
45.14
6

ATOM
1165
NZ
LYS
A
288
66.198
43.730
59.450
1.00
48.71
7

ATOM
1166
C
LYS
A
288
67.125
48.522
63.909
1.00
41.30
6

ATOM
1167
O
LYS
A
288
68.220
48.123
64.291
1.00
41.37
8

ATOM
1168
N
ASN
A
289
66.976
49.590
63.130
1.00
40.14
7

ATOM
1169
CA
ASN
A
289
68.124
50.371
62.689
1.00
39.86
6

ATOM
1170
CB
ASN
A
289
67.995
50.713
61.202
1.00
40.93
6

ATOM
1171
CG
ASN
A
289
68.413
49.559
60.313
1.00
41.80
6

ATOM
1172
OD1
ASN
A
289
68.649
48.449
60.794
1.00
41.87
8

ATOM
1173
ND2
ASN
A
289
68.507
49.812
59.014
1.00
43.28
7

ATOM
1174
C
ASN
A
289
68.348
51.632
63.505
1.00
39.26
6

ATOM
1175
O
ASN
A
289
69.151
52.484
63.133
1.00
40.41
8

ATOM
1176
N
PHE
A
290
67.639
51.754
64.619
1.00
37.80
7

ATOM
1177
CA
PHE
A
290
67.826
52.899
65.490
1.00
38.62
6

ATOM
1178
CB
PHE
A
290
66.497
53.384
66.070
1.00
38.47
6

ATOM
1179
CG
PHE
A
290
65.724
54.279
65.140
1.00
39.34
6

ATOM
1180
CD1
PHE
A
290
64.924
53.742
64.136
1.00
37.04
6

ATOM
1181
CD2
PHE
A
290
65.809
55.666
65.261
1.00
38.75
6

ATOM
1182
CE1
PHE
A
290
64.218
54.570
63.271
1.00
37.47
6

ATOM
1183
CE2
PHE
A
290
65.106
56.505
64.396
1.00
39.72
6

ATOM
1184
CZ
PHE
A
290
64.308
55.955
63.397
1.00
38.28
6

ATOM
1185
C
PHE
A
290
68.764
52.448
66.597
1.00
38.83
6

ATOM
1186
O
PHE
A
290
68.576
51.384
67.190
1.00
37.19
8

ATOM
1187
N
GLN
A
291
69.789
53.249
66.858
1.00
38.72
7

ATOM
1188
CA
GLN
A
291
70.768
52.905
67.880
1.00
40.85
6

ATOM
1189
CB
GLN
A
291
71.880
53.953
67.922
1.00
42.17
6

ATOM
1190
CG
GLN
A
291
73.116
53.520
67.160
1.00
47.34
6

ATOM
1191
CD
GLN
A
291
73.516
52.096
67.505
1.00
49.93
6

ATOM
1192
OE1
GLN
A
291
73.022
51.137
66.909
1.00
50.65
8

ATOM
1193
NE2
GLN
A
291
74.397
51.951
68.490
1.00
51.43
7

ATOM
1194
C
GLN
A
291
70.202
52.692
69.277
1.00
37.98
6

ATOM
1195
O
GLN
A
291
70.640
51.791
69.985
1.00
38.50
8

ATOM
1196
N
TRP
A
292
69.233
53.509
69.673
1.00
36.46
7

ATOM
1197
CA
TRP
A
292
68.633
53.363
70.997
1.00
37.72
6

ATOM
1198
CB
TRP
A
292
67.615
54.475
71.270
1.00
38.01
6

ATOM
1199
CG
TRP
A
292
67.055
54.394
72.658
1.00
40.83
6

ATOM
1200
CD2
TRP
A
292
67.757
54.662
73.878
1.00
40.51
6

ATOM
1201
CE2
TRP
A
292
66.870
54.390
74.940
1.00
41.33
6

ATOM
1202
CE3
TRP
A
292
69.054
55.104
74.175
1.00
42.32
6

ATOM
1203
CD1
TRP
A
292
65.803
53.987
73.019
1.00
39.80
6

ATOM
1204
NE1
TRP
A
292
65.685
53.981
74.389
1.00
39.96
7

ATOM
1205
CZ2
TRP
A
292
67.238
54.544
76.284
1.00
41.81
6

ATOM
1206
CZ3
TRP
A
292
69.420
55.259
75.512
1.00
41.42
6

ATOM
1207
CH2
TRP
A
292
68.512
54.978
76.549
1.00
41.81
6

ATOM
1208
C
TRP
A
292
67.941
52.016
71.100
1.00
37.56
6

ATOM
1209
O
TRP
A
292
67.944
51.378
72.153
1.00
38.94
8

ATOM
1210
N
VAL
A
293
67.336
51.591
69.996
1.00
37.67
7

ATOM
1211
CA
VAL
A
293
66.648
50.309
69.952
1.00
38.63
6

ATOM
1212
CB
VAL
A
293
65.887
50.142
68.618
1.00
38.35
6

ATOM
1213
CG1
VAL
A
293
65.294
48.743
68.518
1.00
38.72
6

ATOM
1214
CG2
VAL
A
293
64.783
51.187
68.523
1.00
38.53
6

ATOM
1215
C
VAL
A
293
67.654
49.169
70.123
1.00
38.97
6

ATOM
1216
O
VAL
A
293
67.391
48.199
70.843
1.00
38.45
8

ATOM
1217
N
ARG
A
294
68.808
49.290
69.471
1.00
37.88
7

ATOM
1218
CA
ARG
A
294
69.836
48.265
69.569
1.00
38.87
6

ATOM
1219
CB
ARG
A
294
70.891
48.458
68.479
1.00
37.83
6

ATOM
1220
CG
ARG
A
294
70.336
48.304
67.073
1.00
37.55
6

ATOM
1221
CD
ARG
A
294
71.443
48.244
66.033
1.00
38.44
6

ATOM
1222
NE
ARG
A
294
70.898
48.121
64.685
1.00
37.10
7

ATOM
1223
CZ
ARG
A
294
71.592
47.719
63.627
1.00
36.10
6

ATOM
1224
NH1
ARG
A
294
72.876
47.399
63.754
1.00
33.60
7

ATOM
1225
NH2
ARG
A
294
70.992
47.616
62.447
1.00
36.18
7

ATOM
1226
C
ARG
A
294
70.481
48.327
70.947
1.00
40.31
6

ATOM
1227
O
ARG
A
294
70.912
47.312
71.495
1.00
38.94
8

ATOM
1228
N
HIS
A
295
70.537
49.532
71.504
1.00
41.82
7

ATOM
1229
CA
HIS
A
295
71.102
49.723
72.829
1.00
43.55
6

ATOM
1230
CB
HIS
A
295
71.117
51.208
73.175
1.00
44.90
6

ATOM
1231
CG
HIS
A
295
71.411
51.485
74.613
1.00
47.15
6

ATOM
1232
CD2
HIS
A
295
70.627
51.970
75.605
1.00
48.79
6

ATOM
1233
ND1
HIS
A
295
72.644
51.245
75.181
1.00
47.09
7

ATOM
1234
CE1
HIS
A
295
72.607
51.571
76.461
1.00
50.25
6

ATOM
1235
NE2
HIS
A
295
71.394
52.013
76.744
1.00
50.75
7

ATOM
1236
C
HIS
A
295
70.244
48.964
73.842
1.00
45.30
6

ATOM
1237
O
HIS
A
295
70.765
48.230
74.684
1.00
45.38
8

ATOM
1238
N
CYS
A
296
68.927
49.149
73.718
1.00
45.70
7

ATOM
1239
CA
CYS
A
296
67.980
48.485
74.610
1.00
46.87
6

ATOM
1240
CB
CYS
A
296
66.571
49.043
74.400
1.00
45.82
6

ATOM
1241
SG
CYS
A
296
66.342
50.748
75.001
1.00
45.53
16

ATOM
1242
C
CYS
A
296
67.967
46.972
74.453
1.00
48.70
6

ATOM
1243
O
CYS
A
296
67.840
46.266
75.460
1.00
49.54
8

ATOM
1244
N
LEU
A
297
68.087
46.462
73.232
1.00
49.73
7

ATOM
1245
CA
LEU
A
297
68.093
45.017
73.052
1.00
51.79
6

ATOM
1246
CB
LEU
A
297
68.026
44.653
71.561
1.00
50.94
6

ATOM
1247
CG
LEU
A
297
66.761
44.998
70.763
1.00
51.64
6

ATOM
1248
CD1
LEU
A
297
66.978
44.721
69.287
1.00
51.47
6

ATOM
1249
CD2
LEU
A
297
65.549
44.235
71.296
1.00
51.62
6

ATOM
1250
C
LEU
A
297
69.340
44.421
73.705
1.00
53.48
6

ATOM
1251
O
LEU
A
297
69.276
43.455
74.474
1.00
53.56
8

ATOM
1252
N
LYS
A
298
70.495
45.016
73.394
1.00
55.12
7

ATOM
1253
CA
LYS
A
298
71.793
44.624
73.919
1.00
57.32
6

ATOM
1254
CB
LYS
A
298
72.874
45.596
73.448
1.00
57.96
6

ATOM
1255
CG
LYS
A
298
74.270
45.263
73.948
1.00
59.97
6

ATOM
1256
CD
LYS
A
298
75.291
46.268
73.441
1.00
60.96
6

ATOM
1257
CE
LYS
A
298
76.688
45.927
73.931
1.00
62.69
6

ATOM
1258
NZ
LYS
A
298
77.704
46.893
73.427
1.00
62.31
7

ATOM
1259
C
LYS
A
298
71.770
44.545
75.440
1.00
58.03
6

ATOM
1260
O
LYS
A
298
72.358
43.651
76.045
1.00
58.09
8

ATOM
1261
N
ASN
A
299
71.065
45.486
76.053
1.00
59.02
7

ATOM
1262
CA
ASN
A
299
70.964
45.516
77.505
1.00
60.84
6

ATOM
1263
CB
ASN
A
299
71.235
46.938
78.002
1.00
60.80
6

ATOM
1264
CG
ASN
A
299
72.637
47.414
77.656
1.00
61.76
6

ATOM
1265
OD1
ASN
A
299
73.630
46.856
78.129
1.00
62.07
8

ATOM
1266
ND2
ASN
A
299
72.725
48.443
76.822
1.00
62.96
7

ATOM
1267
C
ASN
A
299
69.630
45.007
78.041
1.00
61.49
6

ATOM
1268
O
ASN
A
299
69.166
45.429
79.093
1.00
62.24
8

ATOM
1269
N
GLY
A
300
68.994
44.091
77.310
1.00
62.34
7

ATOM
1270
CA
GLY
A
300
67.722
43.521
77.748
1.00
62.14
6

ATOM
1271
C
GLY
A
300
66.754
44.525
78.376
1.00
62.98
6

ATOM
1272
O
GLY
A
300
66.082
44.242
79.369
1.00
63.06
8

ATOM
1273
N
GLU
A
301
66.696
45.710
77.779
1.00
63.26
7

ATOM
1274
CA
GLU
A
301
65.804
46.766
78.244
1.00
63.42
6

ATOM
1275
CB
GLU
A
301
66.504
48.114
78.189
1.00
65.10
6

ATOM
1276
CG
GLU
A
301
67.648
48.272
79.164
1.00
68.21
6

ATOM
1277
CD
GLU
A
301
68.199
49.677
79.165
1.00
70.41
6

ATOM
1278
OE1
GLU
A
301
69.349
49.878
79.606
1.00
71.99
8

ATOM
1279
OE2
GLU
A
301
67.463
50.578
78.735
1.00
71.25
8

ATOM
1280
C
GLU
A
301
64.565
46.886
77.376
1.00
62.94
6

ATOM
1281
O
GLU
A
301
64.585
46.628
76.178
1.00
63.20
8

ATOM
1282
N
GLU
A
302
63.506
47.287
78.043
1.00
61.90
7

ATOM
1283
CA
GLU
A
302
62.251
47.509
77.434
1.00
61.43
6

ATOM
1284
CB
GLU
A
302
61.139
47.250
78.436
1.00
62.82
6

ATOM
1285
CG
GLU
A
302
61.434
46.050
79.331
1.00
64.81
6

ATOM
1286
CD
GLU
A
302
60.351
45.864
80.346
1.00
66.45
6

ATOM
1287
OE1
GLU
A
302
60.040
46.831
81.076
1.00
66.95
8

ATOM
1288
OE2
GLU
A
302
59.794
44.746
80.418
1.00
67.18
8

ATOM
1289
C
GLU
A
302
62.286
48.918
76.830
1.00
59.72
6

ATOM
1290
O
GLU
A
302
62.725
49.880
77.466
1.00
60.18
8

ATOM
1291
N
ILE
A
303
61.799
49.030
75.585
1.00
56.79
7

ATOM
1292
CA
ILE
A
303
61.780
50.286
74.798
1.00
54.83
6

ATOM
1293
CB
ILE
A
303
61.713
49.968
73.285
1.00
54.08
6

ATOM
1294
CG2
ILE
A
303
61.716
51.259
72.476
1.00
53.73
6

ATOM
1295
CG1
ILE
A
303
62.897
49.081
72.889
1.00
53.15
6

ATOM
1296
CD1
ILE
A
303
62.862
48.615
71.449
1.00
51.54
6

ATOM
1297
C
ILE
A
303
60.629
51.219
75.164
1.00
53.89
6

ATOM
1298
O
ILE
A
303
59.505
51.042
74.694
1.00
54.29
8

ATOM
1299
N
HIS
A
304
60.913
52.211
76.002
1.00
52.88
7

ATOM
1300
CA
HIS
A
304
59.898
53.172
76.422
1.00
51.29
6

ATOM
1301
CB
HIS
A
304
60.037
53.503
77.911
1.00
52.76
6

ATOM
1302
CG
HIS
A
304
59.715
52.359
78.818
1.00
54.08
6

ATOM
1303
CD2
HIS
A
304
58.615
52.094
79.562
1.00
54.23
6

ATOM
1304
ND1
HIS
A
304
60.577
51.303
79.022
1.00
55.17
7

ATOM
1305
CE1
HIS
A
304
60.023
50.437
79.853
1.00
55.51
6

ATOM
1306
NE2
HIS
A
304
58.832
50.895
80.195
1.00
54.22
7

ATOM
1307
C
HIS
A
304
59.960
54.464
75.623
1.00
50.52
6

ATOM
1308
O
HIS
A
304
61.018
55.086
75.490
1.00
48.43
8

ATOM
1309
N
VAL
A
305
58.809
54.868
75.105
1.00
49.76
7

ATOM
1310
CA
VAL
A
305
58.718
56.079
74.317
1.00
49.67
6

ATOM
1311
CB
VAL
A
305
58.760
55.749
72.810
1.00
50.96
6

ATOM
1312
CG1
VAL
A
305
58.515
57.002
71.989
1.00
51.45
6

ATOM
1313
CG2
VAL
A
305
60.100
55.116
72.430
1.00
50.42
6

ATOM
1314
C
VAL
A
305
57.472
56.846
74.628
1.00
49.29
6

ATOM
1315
O
VAL
A
305
56.403
56.272
74.903
1.00
47.84
8

ATOM
1316
N
VAL
A
306
57.680
58.124
74.641
1.00
50.50
7

ATOM
1317
CA
VAL
A
306
56.583
58.986
74.822
1.00
51.75
6

ATOM
1318
CB
VAL
A
306
56.845
60.116
75.822
1.00
51.55
6

ATOM
1319
CG1
VAL
A
306
58.048
60.941
75.407
1.00
51.41
6

ATOM
1320
CG2
VAL
A
306
55.618
60.995
75.969
1.00
51.51
6

ATOM
1321
C
VAL
A
306
56.317
59.521
73.489
1.00
53.05
6

ATOM
1322
O
VAL
A
306
57.150
59.543
72.588
1.00
53.60
8

ATOM
1323
N
LEU
A
307
55.089
59.936
73.386
1.00
54.30
7

ATOM
1324
CA
LEU
A
307
54.641
60.453
72.150
1.00
54.99
6

ATOM
1325
CB
LEU
A
307
53.542
59.555
71.616
1.00
55.78
6

ATOM
1326
CG
LEU
A
307
52.238
60.189
71.225
1.00
56.64
6

ATOM
1327
CD1
LEU
A
307
52.363
60.868
69.868
1.00
57.75
6

ATOM
1328
CD2
LEU
A
307
51.125
59.161
71.200
1.00
57.94
6

ATOM
1329
C
LEU
A
307
54.257
61.869
72.358
1.00
55.54
6

ATOM
1330
O
LEU
A
307
53.246
62.177
72.990
1.00
55.97
8

ATOM
1331
N
ASP
A
308
55.063
62.716
71.857
1.00
56.07
7

ATOM
1332
CA
ASP
A
308
54.682
64.064
72.043
1.00
56.52
6

ATOM
1333
CB
ASP
A
308
55.602
64.748
73.045
1.00
58.12
6

ATOM
1334
CG
ASP
A
308
56.883
65.264
72.398
1.00
59.98
6

ATOM
1335
OD1
ASP
A
308
57.109
64.963
71.212
1.00
60.97
8

ATOM
1336
OD2
ASP
A
308
57.646
65.967
73.086
1.00
61.57
8

ATOM
1337
C
ASP
A
308
54.632
64.802
70.756
1.00
55.87
6

ATOM
1338
O
ASP
A
308
54.464
64.261
69.678
1.00
54.53
8

ATOM
1339
N
THR
A
309
54.791
66.053
70.940
1.00
55.96
7

ATOM
1340
CA
THR
A
309
54.712
66.969
69.877
1.00
57.44
6

ATOM
1341
CB
THR
A
309
53.688
68.047
70.261
1.00
58.70
6

ATOM
1342
OG1
THR
A
309
53.666
69.060
69.262
1.00
62.01
8

ATOM
1343
CG2
THR
A
309
54.038
68.650
71.600
1.00
59.88
6

ATOM
1344
C
THR
A
309
56.069
67.500
69.560
1.00
56.32
6

ATOM
1345
O
THR
A
309
56.795
68.001
70.416
1.00
56.02
8

ATOM
1346
N
PRO
A
310
56.378
67.396
68.283
1.00
55.23
7

ATOM
1347
CD
PRO
A
310
55.980
66.187
67.528
1.00
54.52
6

ATOM
1348
CA
PRO
A
310
57.695
67.827
67.794
1.00
53.52
6

ATOM
1349
CB
PRO
A
310
57.591
67.539
66.321
1.00
53.15
6

ATOM
1350
CG
PRO
A
310
56.819
66.260
66.275
1.00
54.43
6

ATOM
1351
C
PRO
A
310
58.313
69.167
68.107
1.00
51.85
6

ATOM
1352
O
PRO
A
310
57.680
70.126
68.527
1.00
52.18
8

ATOM
1353
N
PRO
A
311
59.619
69.160
67.855
1.00
49.76
7

ATOM
1354
CD
PRO
A
311
60.454
68.196
68.582
1.00
48.77
6

ATOM
1355
CA
PRO
A
311
60.323
70.419
67.909
1.00
47.64
6

ATOM
1356
CB
PRO
A
311
61.764
70.035
67.723
1.00
46.84
6

ATOM
1357
CG
PRO
A
311
61.843
68.768
68.487
1.00
47.27
6

ATOM
1358
C
PRO
A
311
59.737
71.345
66.845
1.00
46.76
6

ATOM
1359
O
PRO
A
311
58.810
70.970
66.136
1.00
47.65
8

ATOM
1360
N
ASP
A
312
60.300
72.540
66.741
1.00
45.62
7

ATOM
1361
CA
ASP
A
312
59.994
73.491
65.675
1.00
45.14
6

ATOM
1362
CB
ASP
A
312
59.123
74.725
66.077
1.00
46.67
6

ATOM
1363
CG
ASP
A
312
58.272
75.363
64.945
1.00
48.73
6

ATOM
1364
OD1
ASP
A
312
57.944
74.661
63.978
1.00
51.04
8

ATOM
1365
OD2
ASP
A
312
57.954
76.568
65.049
1.00
50.35
8

ATOM
1366
C
ASP
A
312
61.354
73.897
65.130
1.00
43.48
6

ATOM
1367
O
ASP
A
312
62.254
74.345
65.832
1.00
41.15
8

ATOM
1368
N
PRO
A
313
61.431
73.684
63.821
1.00
43.57
7

ATOM
1369
CD
PRO
A
313
60.894
72.424
63.257
1.00
44.66
6

ATOM
1370
CA
PRO
A
313
62.636
74.035
63.099
1.00
42.37
6

ATOM
1371
CB
PRO
A
313
62.296
73.637
61.660
1.00
44.00
6

ATOM
1372
CG
PRO
A
313
61.504
72.369
61.889
1.00
45.07
6

ATOM
1373
C
PRO
A
313
63.069
75.443
63.373
1.00
41.67
6

ATOM
1374
O
PRO
A
313
64.245
75.780
63.557
1.00
40.31
8

ATOM
1375
N
ALA
A
314
61.993
76.241
63.376
1.00
40.40
7

ATOM
1376
CA
ALA
A
314
62.038
77.684
63.573
1.00
41.14
6

ATOM
1377
CB
ALA
A
314
60.673
78.235
63.965
1.00
42.55
6

ATOM
1378
C
ALA
A
314
63.062
78.016
64.614
1.00
40.28
6

ATOM
1379
O
ALA
A
314
63.717
79.066
64.558
1.00
40.81
8

ATOM
1380
N
LEU
A
315
63.177
77.141
65.548
1.00
39.76
7

ATOM
1381
CA
LEU
A
315
64.094
77.421
66.601
1.00
39.55
6

ATOM
1382
CB
LEU
A
315
63.711
76.577
67.813
1.00
39.74
6

ATOM
1383
CG
LEU
A
315
62.193
76.479
68.084
1.00
40.73
6

ATOM
1384
CD1
LEU
A
315
61.924
75.629
69.314
1.00
41.09
6

ATOM
1385
CD2
LEU
A
315
61.579
77.862
68.250
1.00
40.50
6

ATOM
1386
C
LEU
A
315
65.539
77.292
66.181
1.00
39.90
6

ATOM
1387
O
LEU
A
315
66.426
77.920
66.773
1.00
38.56
8

ATOM
1388
N
ASP
A
316
65.805
76.488
65.158
1.00
39.78
7

ATOM
1389
CA
ASP
A
316
67.155
76.290
64.729
1.00
40.86
6

ATOM
1390
CB
ASP
A
316
67.293
74.918
64.082
1.00
40.22
6

ATOM
1391
CG
ASP
A
316
67.031
73.773
65.044
1.00
40.97
6

ATOM
1392
OD1
ASP
A
316
67.547
73.832
66.184
1.00
40.43
8

ATOM
1393
OD2
ASP
A
316
66.324
72.813
64.666
1.00
38.10
8

ATOM
1394
C
ASP
A
316
67.630
77.379
63.790
1.00
40.87
6

ATOM
1395
O
ASP
A
316
68.686
77.268
63.171
1.00
40.07
8

ATOM
1396
N
GLU
A
317
66.861
78.466
63.699
1.00
43.50
7

ATOM
1397
CA
GLU
A
317
67.114
79.574
62.764
1.00
45.32
6

ATOM
1398
CB
GLU
A
317
66.135
80.700
63.077
1.00
48.53
6

ATOM
1399
CG
GLU
A
317
64.863
80.574
62.271
1.00
53.85
6

ATOM
1400
CD
GLU
A
317
63.842
81.630
62.609
1.00
55.53
6

ATOM
1401
OE1
GLU
A
317
64.221
82.817
62.677
1.00
56.76
8

ATOM
1402
OE2
GLU
A
317
62.662
81.269
62.820
1.00
57.08
8

ATOM
1403
C
GLU
A
317
68.568
80.069
62.657
1.00
45.87
6

ATOM
1404
O
GLU
A
317
69.258
80.246
63.674
1.00
44.16
8

ATOM
1405
N
VAL
A
318
68.999
80.265
61.425
1.00
45.46
7

ATOM
1406
CA
VAL
A
318
70.330
80.776
61.230
1.00
46.54
6

ATOM
1407
CB
VAL
A
318
70.952
80.279
59.906
1.00
45.15
6

ATOM
1408
CG1
VAL
A
318
72.182
81.100
59.557
1.00
42.41
6

ATOM
1409
CG2
VAL
A
318
71.285
78.800
60.002
1.00
42.47
6

ATOM
1410
C
VAL
A
318
70.199
82.260
61.218
1.00
49.57
6

ATOM
1411
O
VAL
A
318
69.080
82.786
61.204
1.00
49.13
8

ATOM
1412
N
ARG
A
319
71.354
82.981
61.240
1.00
52.58
7

ATOM
1413
CA
ARG
A
319
71.411
84.444
61.150
1.00
55.97
6

ATOM
1414
CB
ARG
A
319
72.163
85.077
62.340
1.00
57.05
6

ATOM
1415
CG
ARG
A
319
71.952
86.580
62.518
1.00
58.76
6

ATOM
1416
CD
ARG
A
319
71.761
86.996
63.966
1.00
60.55
6

ATOM
1417
NE
ARG
A
319
71.877
88.434
64.157
1.00
62.82
7

ATOM
1418
CZ
ARG
A
319
72.333
89.004
65.256
1.00
64.04
6

ATOM
1419
NH1
ARG
A
319
72.732
88.253
66.283
1.00
64.96
7

ATOM
1420
NH2
ARG
A
319
72.390
90.323
65.326
1.00
64.36
7

ATOM
1421
C
ARG
A
319
72.029
84.853
59.801
1.00
58.67
6

ATOM
1422
O
ARG
A
319
72.970
84.249
59.283
1.00
58.69
8

ATOM
1423
N
LYS
A
320
71.412
85.914
59.252
1.00
61.11
7

ATOM
1424
CA
LYS
A
320
71.675
86.527
57.933
1.00
63.48
6

ATOM
1425
CB
LYS
A
320
70.771
87.770
57.854
1.00
63.99
6

ATOM
1426
CG
LYS
A
320
69.631
87.801
58.886
1.00
65.14
6

ATOM
1427
CD
LYS
A
320
68.303
87.312
58.330
1.00
65.59
6

ATOM
1428
CE
LYS
A
320
67.348
86.893
59.451
1.00
66.14
6

ATOM
1429
NZ
LYS
A
320
66.382
87.976
59.787
1.00
64.88
7

ATOM
1430
C
LYS
A
320
73.160
86.782
57.653
1.00
64.80
6

ATOM
1431
O
LYS
A
320
73.949
85.840
57.816
1.00
64.57
8

ATOM
1432
N
GLU
A
321
73.592
87.975
57.236
1.00
67.34
7

ATOM
1433
CA
GLU
A
321
75.021
88.148
56.989
1.00
69.48
6

ATOM
1434
CB
GLU
A
321
75.291
88.804
55.607
1.00
70.55
6

ATOM
1435
CG
GLU
A
321
76.510
88.309
54.810
1.00
73.06
6

ATOM
1436
CD
GLU
A
321
76.926
89.208
53.625
1.00
73.59
6

ATOM
1437
OE1
GLU
A
321
77.733
90.136
53.841
1.00
74.86
8

ATOM
1438
OE2
GLU
A
321
76.426
88.982
52.504
1.00
73.72
8

ATOM
1439
C
GLU
A
321
75.612
89.000
58.104
1.00
70.05
6

ATOM
1440
O
GLU
A
321
75.030
89.989
58.547
1.00
70.61
8

ATOM
1441
N
GLY
A
322
76.802
88.604
58.568
1.00
70.18
7

ATOM
1442
CA
GLY
A
322
77.464
89.337
59.616
1.00
70.44
6

ATOM
1443
C
GLY
A
322
78.955
89.516
59.308
1.00
69.97
6

ATOM
1444
O
GLY
A
322
79.350
90.440
58.592
1.00
69.63
8

ATOM
1445
N
VAL
A
352
103.335
84.397
36.291
1.00
26.24
7

ATOM
1446
CA
VAL
A
352
103.442
85.790
36.752
1.00
26.24
6

ATOM
1447
CB
VAL
A
352
102.751
86.747
35.740
1.00
26.24
6

ATOM
1448
CG1
VAL
A
352
101.328
87.062
36.186
1.00
26.24
6

ATOM
1449
CG2
VAL
A
352
103.556
88.031
35.568
1.00
26.24
6

ATOM
1450
C
VAL
A
352
102.862
85.928
38.164
1.00
26.24
6

ATOM
1451
O
VAL
A
352
101.646
85.967
38.372
1.00
26.24
8

ATOM
1452
N
SER
A
353
103.818
86.014
39.126
1.00
26.24
7

ATOM
1453
CA
SER
A
353
103.604
86.226
40.578
1.00
26.24
6

ATOM
1454
CB
SER
A
353
103.572
84.921
41.381
1.00
26.24
6

ATOM
1455
OG
SER
A
353
103.350
85.181
42.757
1.00
26.24
8

ATOM
1456
C
SER
A
353
104.740
87.100
41.071
1.00
26.24
6

ATOM
1457
O
SER
A
353
104.486
88.186
41.577
1.00
26.24
8

ATOM
1458
N
LEU
A
354
106.046
86.657
40.926
1.00
103.21
7

ATOM
1459
CA
LEU
A
354
107.143
87.565
41.352
1.00
103.21
6

ATOM
1460
CB
LEU
A
354
107.153
87.678
42.858
1.00
65.64
6

ATOM
1461
CG
LEU
A
354
106.487
88.947
43.392
1.00
26.24
6

ATOM
1462
CD1
LEU
A
354
106.818
90.135
42.493
1.00
26.24
6

ATOM
1463
CD2
LEU
A
354
104.982
88.775
43.508
1.00
26.24
6

ATOM
1464
C
LEU
A
354
108.570
87.324
40.796
1.00
103.21
6

ATOM
1465
O
LEU
A
354
108.800
86.446
39.979
1.00
103.21
8

ATOM
1466
N
TRP
A
355
109.518
88.186
41.296
1.00
63.62
7

ATOM
1467
CA
TRP
A
355
110.939
88.231
40.899
1.00
63.62
6

ATOM
1468
CB
TRP
A
355
111.746
89.071
41.965
1.00
95.68
6

ATOM
1469
CG
TRP
A
355
112.853
90.012
41.430
1.00
26.24
6

ATOM
1470
CD2
TRP
A
355
113.385
91.245
41.996
1.00
26.24
6

ATOM
1471
CE2
TRP
A
355
114.462
91.655
41.183
1.00
26.24
6

ATOM
1472
CE3
TRP
A
355
113.056
92.011
43.116
1.00
26.24
6

ATOM
1473
CD1
TRP
A
355
113.568
89.818
40.284
1.00
26.24
6

ATOM
1474
NE1
TRP
A
355
114.533
90.789
40.122
1.00
26.24
7

ATOM
1475
CZ2
TRP
A
355
115.277
92.735
41.517
1.00
26.24
6

ATOM
1476
CZ3
TRP
A
355
113.834
93.114
43.414
1.00
26.24
6

ATOM
1477
CH2
TRP
A
355
114.931
93.465
42.619
1.00
26.24
6

ATOM
1478
C
TRP
A
355
111.378
86.785
40.595
1.00
63.62
6

ATOM
1479
O
TRP
A
355
110.563
85.867
40.683
1.00
63.62
8

ATOM
1480
N
ASP
A
356
112.637
86.598
40.233
1.00
65.79
7

ATOM
1481
CA
ASP
A
356
113.195
85.304
39.834
1.00
65.79
6

ATOM
1482
CB
ASP
A
356
114.713
85.375
39.816
1.00
53.16
6

ATOM
1483
CG
ASP
A
356
115.243
85.665
38.423
1.00
26.24
6

ATOM
1484
OD1
ASP
A
356
114.524
86.306
37.632
1.00
26.24
8

ATOM
1485
OD2
ASP
A
356
116.384
85.261
38.134
1.00
26.24
8

ATOM
1486
C
ASP
A
356
112.715
84.103
40.653
1.00
65.79
6

ATOM
1487
O
ASP
A
356
112.717
84.078
41.883
1.00
65.79
8

ATOM
1488
N
CYS
A
357
112.316
83.118
39.876
1.00
92.44
7

ATOM
1489
CA
CYS
A
357
111.897
81.852
40.399
1.00
91.69
6

ATOM
1490
CB
CYS
A
357
110.882
81.158
39.481
1.00
110.85
6

ATOM
1491
SG
CYS
A
357
110.491
82.091
37.960
1.00
115.10
16

ATOM
1492
C
CYS
A
357
113.107
80.990
40.577
1.00
89.52
6

ATOM
1493
O
CYS
A
357
113.078
80.005
41.336
1.00
89.38
8

ATOM
1494
N
ASP
A
358
114.175
81.339
39.880
1.00
56.98
7

ATOM
1495
CA
ASP
A
358
115.329
80.501
39.998
1.00
56.17
6

ATOM
1496
CB
ASP
A
358
115.914
80.267
38.614
1.00
57.77
6

ATOM
1497
CG
ASP
A
358
114.860
79.603
37.761
1.00
58.50
6

ATOM
1498
OD1
ASP
A
358
113.921
80.315
37.351
1.00
58.37
8

ATOM
1499
OD2
ASP
A
358
114.965
78.381
37.498
1.00
59.34
8

ATOM
1500
C
ASP
A
358
116.355
80.998
40.994
1.00
55.12
6

ATOM
1501
O
ASP
A
358
117.469
80.497
41.014
1.00
55.96
8

ATOM
1502
N
ARG
A
359
116.010
81.983
41.819
1.00
52.67
7

ATOM
1503
CA
ARG
A
359
116.956
82.480
42.833
1.00
50.51
6

ATOM
1504
CB
ARG
A
359
116.553
83.870
43.293
1.00
53.35
6

ATOM
1505
CG
ARG
A
359
116.439
84.924
42.201
1.00
58.31
6

ATOM
1506
CD
ARG
A
359
116.130
86.308
42.786
1.00
61.85
6

ATOM
1507
NE
ARG
A
359
116.144
87.347
41.763
1.00
65.28
7

ATOM
1508
CZ
ARG
A
359
115.973
88.639
42.014
1.00
66.54
6

ATOM
1509
NH1
ARG
A
359
115.774
89.051
43.259
1.00
67.51
7

ATOM
1510
NH2
ARG
A
359
116.002
89.518
41.022
1.00
66.69
7

ATOM
1511
C
ARG
A
359
117.021
81.539
44.060
1.00
46.31
6

ATOM
1512
O
ARG
A
359
115.983
81.023
44.486
1.00
44.79
8

ATOM
1513
N
LYS
A
360
118.200
81.309
44.609
1.00
43.23
7

ATOM
1514
CA
LYS
A
360
118.175
80.438
45.764
1.00
41.85
6

ATOM
1515
CB
LYS
A
360
119.578
79.931
46.094
1.00
41.65
6

ATOM
1516
CG
LYS
A
360
120.087
78.851
45.166
1.00
44.19
6

ATOM
1517
CD
LYS
A
360
121.244
78.095
45.801
1.00
46.49
6

ATOM
1518
CE
LYS
A
360
121.715
76.970
44.903
1.00
49.88
6

ATOM
1519
NZ
LYS
A
360
122.727
76.116
45.581
1.00
48.76
7

ATOM
1520
C
LYS
A
360
117.549
81.192
46.931
1.00
40.20
6

ATOM
1521
O
LYS
A
360
117.792
82.397
47.109
1.00
38.60
8

ATOM
1522
N
PHE
A
361
116.740
80.490
47.694
1.00
37.87
7

ATOM
1523
CA
PHE
A
361
116.031
81.087
48.836
1.00
36.51
6

ATOM
1524
CB
PHE
A
361
115.009
80.087
49.396
1.00
35.26
6

ATOM
1525
CG
PHE
A
361
114.312
80.560
50.648
1.00
32.01
6

ATOM
1526
CD1
PHE
A
361
113.179
81.363
50.574
1.00
33.24
6

ATOM
1527
CD2
PHE
A
361
114.796
80.198
51.905
1.00
33.24
6

ATOM
1528
CE1
PHE
A
361
112.529
81.800
51.737
1.00
28.76
6

ATOM
1529
CE2
PHE
A
361
114.155
80.629
53.073
1.00
31.87
6

ATOM
1530
CZ
PHE
A
361
113.018
81.432
52.988
1.00
27.51
6

ATOM
1531
C
PHE
A
361
116.997
81.482
49.939
1.00
35.70
6

ATOM
1532
O
PHE
A
361
117.973
80.785
50.206
1.00
36.25
8

ATOM
1533
N
ARG
A
362
116.730
82.618
50.566
1.00
34.72
7

ATOM
1534
CA
ARG
A
362
117.564
83.108
51.659
1.00
33.83
6

ATOM
1535
CB
ARG
A
362
118.721
83.948
51.121
1.00
34.92
6

ATOM
1536
CG
ARG
A
362
118.292
85.259
50.487
1.00
38.15
6

ATOM
1537
CD
ARG
A
362
119.496
86.139
50.209
1.00
40.29
6

ATOM
1538
NE
ARG
A
362
119.076
87.443
49.705
1.00
40.41
7

ATOM
1539
CZ
ARG
A
362
119.900
88.461
49.468
1.00
41.94
6

ATOM
1540
NH1
ARG
A
362
121.204
88.336
49.687
1.00
39.16
7

ATOM
1541
NH2
ARG
A
362
119.415
89.609
49.016
1.00
39.73
7

ATOM
1542
C
ARG
A
362
116.708
83.860
52.641
1.00
31.15
6

ATOM
1543
O
ARG
A
362
115.603
84.297
52.333
1.00
29.33
8

ATOM
1544
N
VAL
A
363
117.226
83.999
53.816
1.00
30.99
7

ATOM
1545
CA
VAL
A
363
116.528
84.616
54.908
1.00
31.35
6

ATOM
1546
CB
VAL
A
363
115.815
83.535
55.758
1.00
30.32
6

ATOM
1547
CG1
VAL
A
363
116.811
82.521
56.305
1.00
33.75
6

ATOM
1548
CG2
VAL
A
363
115.038
84.176
56.888
1.00
30.23
6

ATOM
1549
C
VAL
A
363
117.523
85.292
55.763
1.00
30.54
6

ATOM
1550
O
VAL
A
363
118.559
84.701
56.066
1.00
30.53
8

ATOM
1551
N
LYS
A
364
117.279
86.523
56.179
1.00
29.22
7

ATOM
1552
CA
LYS
A
364
118.227
87.171
57.094
1.00
29.03
6

ATOM
1553
CB
LYS
A
364
118.440
88.651
56.751
1.00
30.92
6

ATOM
1554
CG
LYS
A
364
119.319
89.358
57.751
1.00
31.02
6

ATOM
1555
CD
LYS
A
364
119.440
90.844
57.427
1.00
34.24
6

ATOM
1556
CE
LYS
A
364
120.285
91.075
56.179
1.00
37.73
6

ATOM
1557
NZ
LYS
A
364
120.579
92.520
55.963
1.00
39.20
7

ATOM
1558
C
LYS
A
364
117.741
87.062
58.525
1.00
27.98
6

ATOM
1559
O
LYS
A
364
116.591
87.344
58.825
1.00
29.30
8

ATOM
1560
N
ILE
A
365
118.637
86.640
59.399
1.00
29.27
7

ATOM
1561
CA
ILE
A
365
118.338
86.520
60.807
1.00
27.96
6

ATOM
1562
CB
ILE
A
365
119.054
85.308
61.413
1.00
29.40
6

ATOM
1563
CG2
ILE
A
365
118.698
85.179
62.882
1.00
26.96
6

ATOM
1564
CG1
ILE
A
365
118.703
84.040
60.618
1.00
27.17
6

ATOM
1565
CD1
ILE
A
365
117.230
83.699
60.586
1.00
20.52
6

ATOM
1566
C
ILE
A
365
118.932
87.800
61.395
1.00
29.99
6

ATOM
1567
O
ILE
A
365
120.154
87.952
61.469
1.00
30.68
8

ATOM
1568
N
ARG
A
366
118.076
88.736
61.778
1.00
30.08
7

ATOM
1569
CA
ARG
A
366
118.564
89.989
62.346
1.00
31.76
6

ATOM
1570
CB
ARG
A
366
117.450
91.039
62.319
1.00
32.42
6

ATOM
1571
CG
ARG
A
366
116.968
91.327
60.888
1.00
36.06
6

ATOM
1572
CD
ARG
A
366
115.798
92.308
60.817
1.00
41.26
6

ATOM
1573
NE
ARG
A
366
116.190
93.544
60.147
1.00
45.95
7

ATOM
1574
CZ
ARG
A
366
115.444
94.189
59.256
1.00
45.65
6

ATOM
1575
NH1
ARG
A
366
114.250
93.722
58.907
1.00
44.27
7

ATOM
1576
NH2
ARG
A
366
115.896
95.310
58.714
1.00
48.75
7

ATOM
1577
C
ARG
A
366
119.054
89.734
63.767
1.00
31.02
6

ATOM
1578
O
ARG
A
366
120.202
90.034
64.100
1.00
32.25
8

ATOM
1579
N
GLY
A
367
118.197
89.178
64.596
1.00
30.10
7

ATOM
1580
CA
GLY
A
367
118.627
88.859
65.930
1.00
28.56
6

ATOM
1581
C
GLY
A
367
117.463
88.303
66.735
1.00
27.96
6

ATOM
1582
O
GLY
A
367
116.318
88.239
66.260
1.00
25.01
8

ATOM
1583
N
ILE
A
368
117.780
87.914
67.939
1.00
28.62
7

ATOM
1584
CA
ILE
A
368
116.773
87.417
68.842
1.00
30.61
6

ATOM
1585
CB
ILE
A
368
117.103
86.020
69.378
1.00
30.60
6

ATOM
1586
CG2
ILE
A
368
117.745
85.161
68.291
1.00
28.95
6

ATOM
1587
CG1
ILE
A
368
118.041
86.185
70.575
1.00
30.79
6

ATOM
1588
CD1
ILE
A
368
118.404
84.887
71.251
1.00
34.89
6

ATOM
1589
C
ILE
A
368
116.657
88.397
69.958
1.00
31.31
6

ATOM
1590
O
ILE
A
368
117.427
89.346
70.067
1.00
31.06
8

ATOM
1591
N
ASP
A
369
115.677
88.141
70.817
1.00
32.79
7

ATOM
1592
CA
ASP
A
369
115.449
89.089
71.882
1.00
35.22
6

ATOM
1593
CB
ASP
A
369
115.003
90.393
71.215
1.00
38.87
6

ATOM
1594
CG
ASP
A
369
114.768
91.503
72.180
1.00
44.73
6

ATOM
1595
OD1
ASP
A
369
114.885
92.680
71.800
1.00
46.24
8

ATOM
1596
OD2
ASP
A
369
114.462
91.190
73.365
1.00
45.44
8

ATOM
1597
C
ASP
A
369
114.470
88.625
72.965
1.00
34.43
6

ATOM
1598
O
ASP
A
369
113.347
88.203
72.673
1.00
31.45
8

ATOM
1599
N
ILE
A
370
114.960
88.709
74.239
1.00
35.01
7

ATOM
1600
CA
ILE
A
370
114.230
88.359
75.475
1.00
37.27
6

ATOM
1601
CB
ILE
A
370
114.564
86.923
75.936
1.00
38.85
6

ATOM
1602
CG2
ILE
A
370
115.710
86.933
76.928
1.00
36.03
6

ATOM
1603
CG1
ILE
A
370
113.342
86.204
76.529
1.00
41.90
6

ATOM
1604
CD1
ILE
A
370
113.626
84.793
76.983
1.00
45.17
6

ATOM
1605
C
ILE
A
370
114.597
89.286
76.632
1.00
38.32
6

ATOM
1606
O
ILE
A
370
115.743
89.681
76.847
1.00
35.74
8

ATOM
1607
N
PRO
A
371
113.527
89.603
77.371
1.00
39.96
7

ATOM
1608
CD
PRO
A
371
112.354
89.990
76.612
1.00
41.59
6

ATOM
1609
CA
PRO
A
371
113.628
90.500
78.541
1.00
43.08
6

ATOM
1610
CB
PRO
A
371
112.158
90.662
78.932
1.00
41.63
6

ATOM
1611
CG
PRO
A
371
111.477
90.709
77.596
1.00
42.26
6

ATOM
1612
C
PRO
A
371
114.586
90.083
79.647
1.00
45.58
6

ATOM
1613
O
PRO
A
371
115.585
90.726
79.949
1.00
46.13
8

ATOM
1614
N
VAL
A
372
114.174
88.933
80.342
1.00
48.89
7

ATOM
1615
CA
VAL
A
372
114.756
88.235
81.573
1.00
53.86
6

ATOM
1616
CB
VAL
A
372
113.615
87.914
82.553
1.00
53.36
6

ATOM
1617
CG1
VAL
A
372
114.068
88.133
83.994
1.00
52.96
6

ATOM
1618
CG2
VAL
A
372
112.375
88.762
82.246
1.00
53.07
6

ATOM
1619
C
VAL
A
372
115.461
86.906
81.301
1.00
57.32
6

ATOM
1620
O
VAL
A
372
114.961
86.092
80.524
1.00
57.52
8

ATOM
1621
N
LEU
A
373
116.634
86.586
81.970
1.00
61.39
7

ATOM
1622
CA
LEU
A
373
117.302
85.295
81.627
1.00
65.98
6

ATOM
1623
CB
LEU
A
373
118.033
85.504
80.327
1.00
66.33
6

ATOM
1624
CG
LEU
A
373
117.894
84.349
79.349
1.00
66.68
6

ATOM
1625
CD1
LEU
A
373
118.007
84.848
77.922
1.00
66.83
6

ATOM
1626
CD2
LEU
A
373
118.925
83.275
79.626
1.00
67.73
6

ATOM
1627
C
LEU
A
373
118.268
84.517
82.594
1.00
68.85
6

ATOM
1628
O
LEU
A
373
119.487
84.553
82.403
1.00
70.08
8

ATOM
1629
N
PRO
A
374
117.715
83.820
83.628
1.00
70.66
7

ATOM
1630
CD
PRO
A
374
116.863
84.557
84.590
1.00
70.73
6

ATOM
1631
CA
PRO
A
374
118.574
82.994
84.481
1.00
72.57
6

ATOM
1632
CB
PRO
A
374
117.659
82.530
85.596
1.00
72.65
6

ATOM
1633
CG
PRO
A
374
116.831
83.735
85.842
1.00
72.24
6

ATOM
1634
C
PRO
A
374
119.394
81.873
83.848
1.00
74.37
6

ATOM
1635
O
PRO
A
374
119.253
80.714
84.239
1.00
74.01
8

ATOM
1636
N
LEU
A
379
125.852
80.376
79.051
1.00
70.76
7

ATOM
1637
CA
LEU
A
379
125.910
79.427
77.945
1.00
67.57
6

ATOM
1638
CB
LEU
A
379
124.700
78.480
77.977
1.00
68.98
6

ATOM
1639
CG
LEU
A
379
125.018
76.977
78.094
1.00
69.23
6

ATOM
1640
CD1
LEU
A
379
123.846
76.153
77.581
1.00
68.26
6

ATOM
1641
CD2
LEU
A
379
126.294
76.623
77.330
1.00
69.30
6

ATOM
1642
C
LEU
A
379
125.879
80.290
76.704
1.00
64.19
6

ATOM
1643
O
LEU
A
379
125.563
81.464
76.812
1.00
62.46
8

ATOM
1644
N
THR
A
380
126.168
79.780
75.556
1.00
60.90
7

ATOM
1645
CA
THR
A
380
126.059
80.712
74.441
1.00
56.99
6

ATOM
1646
CB
THR
A
380
127.293
80.607
73.549
1.00
57.62
6

ATOM
1647
OG1
THR
A
380
127.314
81.702
72.636
1.00
59.02
8

ATOM
1648
CG2
THR
A
380
127.266
79.310
72.768
1.00
57.22
6

ATOM
1649
C
THR
A
380
124.716
80.465
73.714
1.00
53.64
6

ATOM
1650
O
THR
A
380
123.714
80.286
74.412
1.00
52.87
8

ATOM
1651
N
VAL
A
381
124.647
80.448
72.371
1.00
49.68
7

ATOM
1652
CA
VAL
A
381
123.384
80.225
71.649
1.00
46.32
6

ATOM
1653
CB
VAL
A
381
122.244
81.114
72.197
1.00
46.20
6

ATOM
1654
CG1
VAL
A
381
121.275
81.493
71.081
1.00
47.99
6

ATOM
1655
CG2
VAL
A
381
121.513
80.423
73.340
1.00
45.82
6

ATOM
1656
C
VAL
A
381
123.523
80.553
70.139
1.00
42.87
6

ATOM
1657
O
VAL
A
381
124.247
81.478
69.776
1.00
40.64
8

ATOM
1658
N
PHE
A
382
122.831
79.802
69.291
1.00
40.36
7

ATOM
1659
CA
PHE
A
382
122.857
80.050
67.856
1.00
38.03
6

ATOM
1660
CB
PHE
A
382
123.894
79.171
67.134
1.00
37.65
6

ATOM
1661
CG
PHE
A
382
123.518
77.722
67.034
1.00
38.05
6

ATOM
1662
CD1
PHE
A
382
123.868
76.826
68.040
1.00
39.20
6

ATOM
1663
CD2
PHE
A
382
122.830
77.245
65.926
1.00
37.75
6

ATOM
1664
CE1
PHE
A
382
123.538
75.470
67.937
1.00
38.75
6

ATOM
1665
CE2
PHE
A
382
122.497
75.895
65.814
1.00
38.59
6

ATOM
1666
CZ
PHE
A
382
122.851
75.006
66.818
1.00
37.07
6

ATOM
1667
C
PHE
A
382
121.458
79.783
67.300
1.00
36.13
6

ATOM
1668
O
PHE
A
382
120.610
79.201
67.980
1.00
35.72
8

ATOM
1669
N
VAL
A
383
121.210
80.229
66.076
1.00
33.99
7

ATOM
1670
CA
VAL
A
383
119.910
80.025
65.461
1.00
32.05
6

ATOM
1671
CB
VAL
A
383
119.338
81.345
64.896
1.00
31.18
6

ATOM
1672
CG1
VAL
A
383
118.195
81.060
63.932
1.00
31.69
6

ATOM
1673
CG2
VAL
A
383
118.840
82.219
66.035
1.00
33.40
6

ATOM
1674
C
VAL
A
383
119.987
79.002
64.334
1.00
31.98
6

ATOM
1675
O
VAL
A
383
120.869
79.064
63.475
1.00
31.58
8

ATOM
1676
N
GLU
A
384
119.058
78.057
64.358
1.00
31.24
7

ATOM
1677
CA
GLU
A
384
118.969
77.037
63.328
1.00
31.91
6

ATOM
1678
CB
GLU
A
384
118.814
75.656
63.962
1.00
33.82
6

ATOM
1679
CG
GLU
A
384
118.062
74.656
63.086
1.00
37.35
6

ATOM
1680
CD
GLU
A
384
118.373
73.218
63.459
1.00
39.05
6

ATOM
1681
OE1
GLU
A
384
117.426
72.408
63.621
1.00
38.26
8

ATOM
1682
OE2
GLU
A
384
119.572
72.905
63.604
1.00
39.27
8

ATOM
1683
C
GLU
A
384
117.747
77.325
62.457
1.00
30.72
6

ATOM
1684
O
GLU
A
384
116.632
77.448
62.963
1.00
30.78
8

ATOM
1685
N
ALA
A
385
117.958
77.441
61.152
1.00
30.13
7

ATOM
1686
CA
ALA
A
385
116.860
77.689
60.227
1.00
28.42
6

ATOM
1687
CB
ALA
A
385
117.171
78.899
59.368
1.00
27.92
6

ATOM
1688
C
ALA
A
385
116.684
76.450
59.351
1.00
28.43
6

ATOM
1689
O
ALA
A
385
117.615
76.034
58.670
1.00
29.37
8

ATOM
1690
N
ASN
A
386
115.490
75.867
59.372
1.00
29.34
7

ATOM
1691
CA
ASN
A
386
115.191
74.668
58.591
1.00
28.74
6

ATOM
1692
CB
ASN
A
386
114.808
73.495
59.510
1.00
28.36
6

ATOM
1693
CG
ASN
A
386
115.867
73.178
60.542
1.00
29.12
6

ATOM
1694
OD1
ASN
A
386
116.983
72.773
60.209
1.00
27.30
8

ATOM
1695
ND2
ASN
A
386
115.525
73.366
61.808
1.00
30.29
7

ATOM
1696
C
ASN
A
386
114.016
74.900
57.660
1.00
28.79
6

ATOM
1697
O
ASN
A
386
113.052
75.586
58.030
1.00
29.45
8

ATOM
1698
N
ILE
A
387
114.120
74.367
56.457
1.00
27.43
7

ATOM
1699
CA
ILE
A
387
113.006
74.430
55.515
1.00
27.21
6

ATOM
1700
CB
ILE
A
387
113.435
74.626
54.056
1.00
26.51
6

ATOM
1701
CG2
ILE
A
387
112.221
74.764
53.161
1.00
26.17
6

ATOM
1702
CG1
ILE
A
387
114.338
75.861
53.917
1.00
29.16
6

ATOM
1703
CD1
ILE
A
387
113.643
77.175
54.213
1.00
32.00
6

ATOM
1704
C
ILE
A
387
112.352
73.091
55.654
1.00
30.82
6

ATOM
1705
O
ILE
A
387
112.972
72.056
55.460
1.00
30.07
8

ATOM
1706
N
GLN
A
388
111.092
73.068
55.996
1.00
30.30
7

ATOM
1707
CA
GLN
A
388
110.508
71.775
56.198
1.00
30.67
6

ATOM
1708
CB
GLN
A
388
110.180
71.563
57.658
1.00
31.79
6

ATOM
1709
CG
GLN
A
388
111.354
71.455
58.573
1.00
37.81
6

ATOM
1710
CD
GLN
A
388
110.834
71.422
59.981
1.00
40.42
6

ATOM
1711
OE1
GLN
A
388
109.785
70.822
60.251
1.00
44.02
8

ATOM
1712
NE2
GLN
A
388
111.391
71.986
61.056
1.00
38.20
7

ATOM
1713
C
GLN
A
388
109.212
71.541
55.538
1.00
30.14
6

ATOM
1714
O
GLN
A
388
108.450
72.469
55.265
1.00
30.76
8

ATOM
1715
N
HIS
A
389
108.940
70.302
55.232
1.00
30.27
7

ATOM
1716
CA
HIS
A
389
107.650
70.074
54.699
1.00
30.60
6

ATOM
1717
CB
HIS
A
389
107.658
69.573
53.299
1.00
28.19
6

ATOM
1718
CG
HIS
A
389
106.352
70.080
52.657
1.00
25.37
6

ATOM
1719
CD2
HIS
A
389
106.116
71.228
51.980
1.00
26.46
6

ATOM
1720
ND1
HIS
A
389
105.163
69.381
52.677
1.00
26.07
7

ATOM
1721
CE1
HIS
A
389
104.253
70.072
52.045
1.00
27.68
6

ATOM
1722
NE2
HIS
A
389
104.805
71.196
51.598
1.00
28.24
7

ATOM
1723
C
HIS
A
389
106.902
69.118
55.566
1.00
32.78
6

ATOM
1724
O
HIS
A
389
107.334
67.990
55.770
1.00
30.39
8

ATOM
1725
N
GLY
A
390
105.776
69.557
56.067
1.00
35.56
7

ATOM
1726
CA
GLY
A
390
105.201
68.680
57.000
1.00
38.01
6

ATOM
1727
C
GLY
A
390
106.420
68.450
57.847
1.00
41.02
6

ATOM
1728
O
GLY
A
390
107.028
69.421
58.304
1.00
40.60
8

ATOM
1729
N
GLN
A
391
106.786
67.263
58.132
1.00
43.40
7

ATOM
1730
CA
GLN
A
391
107.975
67.225
58.950
1.00
46.51
6

ATOM
1731
CB
GLN
A
391
107.657
66.763
60.363
1.00
48.37
6

ATOM
1732
CG
GLN
A
391
108.243
65.451
60.804
1.00
50.47
6

ATOM
1733
CD
GLN
A
391
107.373
64.832
61.863
1.00
51.81
6

ATOM
1734
OE1
GLN
A
391
106.131
64.863
61.773
1.00
52.47
8

ATOM
1735
NE2
GLN
A
391
107.802
64.209
62.960
1.00
53.23
7

ATOM
1736
C
GLN
A
391
109.008
66.432
58.214
1.00
48.25
6

ATOM
1737
O
GLN
A
391
109.019
65.190
58.254
1.00
49.70
8

ATOM
1738
N
GLN
A
392
109.880
67.169
57.546
1.00
49.28
7

ATOM
1739
CA
GLN
A
392
110.924
66.621
56.735
1.00
48.95
6

ATOM
1740
CB
GLN
A
392
110.326
65.774
55.615
1.00
50.57
6

ATOM
1741
CG
GLN
A
392
110.730
66.192
54.225
1.00
52.12
6

ATOM
1742
CD
GLN
A
392
109.666
65.874
53.175
1.00
54.36
6

ATOM
1743
OE1
GLN
A
392
108.941
66.762
52.730
1.00
55.58
8

ATOM
1744
NE2
GLN
A
392
109.420
64.675
52.657
1.00
55.46
7

ATOM
1745
C
GLN
A
392
111.774
67.748
56.193
1.00
47.23
6

ATOM
1746
O
GLN
A
392
111.452
68.338
55.167
1.00
45.76
8

ATOM
1747
N
VAL
A
393
112.871
68.052
56.893
1.00
45.37
7

ATOM
1748
CA
VAL
A
393
113.758
69.159
56.572
1.00
43.58
6

ATOM
1749
CB
VAL
A
393
114.556
69.515
57.832
1.00
44.03
6

ATOM
1750
CG1
VAL
A
393
113.617
69.951
58.950
1.00
43.96
6

ATOM
1751
CG2
VAL
A
393
115.434
68.352
58.278
1.00
45.17
6

ATOM
1752
C
VAL
A
393
114.622
68.974
55.323
1.00
41.16
6

ATOM
1753
O
VAL
A
393
115.622
68.269
55.309
1.00
41.10
8

ATOM
1754
N
LEU
A
394
114.147
69.659
54.256
1.00
39.17
7

ATOM
1755
CA
LEU
A
394
114.723
69.708
52.896
1.00
38.62
6

ATOM
1756
CB
LEU
A
394
113.703
70.307
51.928
1.00
37.59
6

ATOM
1757
CG
LEU
A
394
112.316
70.509
52.493
1.00
36.77
6

ATOM
1758
CD1
LEU
A
394
111.440
71.303
51.542
1.00
35.32
6

ATOM
1759
CD2
LEU
A
394
111.676
69.175
52.814
1.00
36.94
6

ATOM
1760
C
LEU
A
394
116.028
70.483
52.857
1.00
40.82
6

ATOM
1761
O
LEU
A
394
116.926
70.159
52.081
1.00
40.75
8

ATOM
1762
N
CYS
A
395
116.157
71.516
53.701
1.00
39.53
7

ATOM
1763
CA
CYS
A
395
117.378
72.337
53.771
1.00
39.94
6

ATOM
1764
CB
CYS
A
395
117.305
73.510
52.785
1.00
41.74
6

ATOM
1765
SG
CYS
A
395
118.855
74.445
52.597
1.00
52.80
16

ATOM
1766
C
CYS
A
395
117.595
72.817
55.178
1.00
37.07
6

ATOM
1767
O
CYS
A
395
116.680
72.867
56.005
1.00
35.84
8

ATOM
1768
N
GLN
A
396
118.845
73.175
55.468
1.00
35.22
7

ATOM
1769
CA
GLN
A
396
119.196
73.573
56.821
1.00
35.93
6

ATOM
1770
CB
GLN
A
396
119.464
72.326
57.643
1.00
38.55
6

ATOM
1771
CG
GLN
A
396
119.684
72.569
59.124
1.00
41.41
6

ATOM
1772
CD
GLN
A
396
119.848
71.278
59.898
1.00
46.21
6

ATOM
1773
OE1
GLN
A
396
120.849
70.573
59.739
1.00
48.98
8

ATOM
1774
NE2
GLN
A
396
118.996
70.759
60.783
1.00
44.86
7

ATOM
1775
C
GLN
A
396
120.408
74.468
56.863
1.00
36.84
6

ATOM
1776
O
GLN
A
396
121.418
74.200
56.236
1.00
35.42
8

ATOM
1777
N
ARG
A
397
120.272
75.554
57.617
1.00
35.45
7

ATOM
1778
CA
ARG
A
397
121.361
76.512
57.755
1.00
34.90
6

ATOM
1779
CB
ARG
A
397
121.161
77.711
56.834
1.00
34.19
6

ATOM
1780
CG
ARG
A
397
121.377
77.394
55.362
1.00
36.90
6

ATOM
1781
CD
ARG
A
397
122.816
77.021
55.082
1.00
37.11
6

ATOM
1782
NE
ARG
A
397
123.025
76.637
53.696
1.00
41.65
7

ATOM
1783
CZ
ARG
A
397
122.695
75.444
53.199
1.00
41.03
6

ATOM
1784
NH1
ARG
A
397
122.139
74.521
53.968
1.00
41.60
7

ATOM
1785
NH2
ARG
A
397
122.936
75.181
51.919
1.00
43.71
7

ATOM
1786
C
ARG
A
397
121.433
76.961
59.215
1.00
35.76
6

ATOM
1787
O
ARG
A
397
120.413
77.011
59.913
1.00
34.91
8

ATOM
1788
N
ARG
A
398
122.633
77.300
59.678
1.00
34.74
7

ATOM
1789
CA
ARG
A
398
122.832
77.746
61.056
1.00
37.25
6

ATOM
1790
CB
ARG
A
398
123.533
76.658
61.876
1.00
38.07
6

ATOM
1791
CG
ARG
A
398
122.731
75.391
62.105
1.00
41.08
6

ATOM
1792
CD
ARG
A
398
123.521
74.400
62.957
1.00
43.72
6

ATOM
1793
NE
ARG
A
398
122.644
73.464
63.657
1.00
48.05
7

ATOM
1794
CZ
ARG
A
398
123.064
72.526
64.505
1.00
49.64
6

ATOM
1795
NH1
ARG
A
398
124.360
72.386
64.760
1.00
50.42
7

ATOM
1796
NH2
ARG
A
398
122.185
71.746
65.124
1.00
49.74
7

ATOM
1797
C
ARG
A
398
123.677
79.019
61.121
1.00
38.18
6

ATOM
1798
O
ARG
A
398
124.371
79.364
60.162
1.00
37.91
8

ATOM
1799
N
THR
A
399
123.600
79.714
62.253
1.00
38.85
7

ATOM
1800
CA
THR
A
399
124.385
80.929
62.484
1.00
38.12
6

ATOM
1801
CB
THR
A
399
123.580
82.041
63.207
1.00
37.52
6

ATOM
1802
OG1
THR
A
399
123.278
81.609
64.543
1.00
36.49
8

ATOM
1803
CG2
THR
A
399
122.290
82.360
62.465
1.00
34.49
6

ATOM
1804
C
THR
A
399
125.505
80.536
63.442
1.00
39.63
6

ATOM
1805
O
THR
A
399
125.491
79.446
64.009
1.00
38.64
8

ATOM
1806
N
SER
A
400
126.394
81.470
63.668
1.00
41.50
7

ATOM
1807
CA
SER
A
400
127.499
81.300
64.585
1.00
43.23
6

ATOM
1808
CB
SER
A
400
128.623
82.307
64.287
1.00
44.49
6

ATOM
1809
OG
SER
A
400
128.117
83.618
64.133
1.00
47.82
8

ATOM
1810
C
SER
A
400
127.046
81.478
66.051
1.00
44.15
6

ATOM
1811
O
SER
A
400
126.212
82.314
66.387
1.00
44.13
8

ATOM
1812
N
PRO
A
401
127.674
80.621
66.890
1.00
45.15
7

ATOM
1813
CD
PRO
A
401
127.723
79.218
66.449
1.00
46.04
6

ATOM
1814
CA
PRO
A
401
127.425
80.603
68.361
1.00
45.95
6

ATOM
1815
CB
PRO
A
401
128.236
79.435
68.855
1.00
46.61
6

ATOM
1816
CG
PRO
A
401
128.048
78.475
67.719
1.00
46.93
6

ATOM
1817
C
PRO
A
401
127.718
81.942
69.000
1.00
46.44
6

ATOM
1818
O
PRO
A
401
128.783
82.496
68.751
1.00
47.15
8

ATOM
1819
N
LYS
A
402
126.816
82.413
69.839
1.00
46.22
7

ATOM
1820
CA
LYS
A
402
127.087
83.695
70.440
1.00
46.23
6

ATOM
1821
CB
LYS
A
402
126.356
84.811
69.699
1.00
43.82
6

ATOM
1822
CG
LYS
A
402
127.013
85.235
68.398
1.00
44.50
6

ATOM
1823
CD
LYS
A
402
126.507
86.588
67.930
1.00
43.79
6

ATOM
1824
CE
LYS
A
402
127.343
87.120
66.770
1.00
43.04
6

ATOM
1825
NZ
LYS
A
402
126.653
88.220
66.050
1.00
43.86
7

ATOM
1826
C
LYS
A
402
126.687
83.774
71.876
1.00
46.53
6

ATOM
1827
O
LYS
A
402
126.202
82.832
72.478
1.00
47.86
8

ATOM
1828
N
PRO
A
403
126.916
84.969
72.388
1.00
46.77
7

ATOM
1829
CD
PRO
A
403
128.230
85.487
72.078
1.00
44.23
6

ATOM
1830
CA
PRO
A
403
126.562
85.274
73.780
1.00
45.45
6

ATOM
1831
CB
PRO
A
403
127.165
86.668
73.937
1.00
45.28
6

ATOM
1832
CG
PRO
A
403
128.410
86.565
73.108
1.00
44.61
6

ATOM
1833
C
PRO
A
403
125.100
85.105
74.182
1.00
44.00
6

ATOM
1834
O
PRO
A
403
124.249
85.785
73.602
1.00
42.44
8

ATOM
1835
N
PHE
A
404
124.744
84.267
75.121
1.00
43.96
7

ATOM
1836
CA
PHE
A
404
123.313
84.318
75.410
1.00
43.12
6

ATOM
1837
CB
PHE
A
404
122.736
83.017
75.981
1.00
42.95
6

ATOM
1838
CG
PHE
A
404
121.226
82.983
75.922
1.00
41.24
6

ATOM
1839
CD1
PHE
A
404
120.498
83.924
75.194
1.00
42.33
6

ATOM
1840
CD2
PHE
A
404
120.532
81.992
76.614
1.00
41.66
6

ATOM
1841
CE1
PHE
A
404
119.103
83.884
75.156
1.00
40.05
6

ATOM
1842
CE2
PHE
A
404
119.133
81.940
76.582
1.00
41.22
6

ATOM
1843
CZ
PHE
A
404
118.417
82.892
75.850
1.00
42.11
6

ATOM
1844
C
PHE
A
404
123.018
85.486
76.332
1.00
42.88
6

ATOM
1845
O
PHE
A
404
123.128
85.370
77.553
1.00
43.09
8

ATOM
1846
N
THR
A
405
122.645
86.613
75.728
1.00
43.06
7

ATOM
1847
CA
THR
A
405
122.267
87.829
76.454
1.00
42.09
6

ATOM
1848
CB
THR
A
405
123.201
89.020
76.127
1.00
42.12
6

ATOM
1849
OG1
THR
A
405
123.041
89.396
74.751
1.00
41.22
8

ATOM
1850
CG2
THR
A
405
124.658
88.646
76.395
1.00
41.76
6

ATOM
1851
C
THR
A
405
120.845
88.221
76.036
1.00
42.13
6

ATOM
1852
O
THR
A
405
120.341
87.752
75.016
1.00
41.19
8

ATOM
1853
N
GLU
A
406
120.215
89.091
76.823
1.00
40.87
7

ATOM
1854
CA
GLU
A
406
118.851
89.547
76.561
1.00
40.98
6

ATOM
1855
CB
GLU
A
406
118.527
90.718
77.484
1.00
43.33
6

ATOM
1856
CG
GLU
A
406
119.006
90.453
78.905
1.00
48.92
6

ATOM
1857
CD
GLU
A
406
118.657
91.566
79.861
1.00
51.91
6

ATOM
1858
OE1
GLU
A
406
119.038
92.725
79.587
1.00
54.04
8

ATOM
1859
OE2
GLU
A
406
118.007
91.272
80.889
1.00
53.97
8

ATOM
1860
C
GLU
A
406
118.643
89.933
75.097
1.00
39.83
6

ATOM
1861
O
GLU
A
406
117.528
89.866
74.579
1.00
40.00
8

ATOM
1862
N
GLU
A
407
119.710
90.351
74.433
1.00
37.21
7

ATOM
1863
CA
GLU
A
407
119.611
90.678
73.022
1.00
37.87
6

ATOM
1864
CB
GLU
A
407
119.462
92.184
72.797
1.00
38.69
6

ATOM
1865
CG
GLU
A
407
119.257
92.531
71.319
1.00
39.28
6

ATOM
1866
CD
GLU
A
407
119.528
93.990
70.995
1.00
40.65
6

ATOM
1867
OE1
GLU
A
407
120.611
94.499
71.364
1.00
40.39
8

ATOM
1868
OE2
GLU
A
407
118.663
94.626
70.359
1.00
41.98
8

ATOM
1869
C
GLU
A
407
120.856
90.173
72.294
1.00
38.31
6

ATOM
1870
O
GLU
A
407
121.982
90.521
72.652
1.00
37.11
8

ATOM
1871
N
VAL
A
408
120.642
89.331
71.288
1.00
37.85
7

ATOM
1872
CA
VAL
A
408
121.733
88.781
70.492
1.00
37.42
6

ATOM
1873
CB
VAL
A
408
121.811
87.252
70.604
1.00
37.35
6

ATOM
1874
CG1
VAL
A
408
122.957
86.737
69.752
1.00
36.54
6

ATOM
1875
CG2
VAL
A
408
121.988
86.845
72.051
1.00
36.25
6

ATOM
1876
C
VAL
A
408
121.480
89.133
69.038
1.00
38.09
6

ATOM
1877
O
VAL
A
408
120.413
88.844
68.506
1.00
36.33
8

ATOM
1878
N
LEU
A
409
122.471
89.752
68.401
1.00
39.25
7

ATOM
1879
CA
LEU
A
409
122.350
90.166
67.012
1.00
40.24
6

ATOM
1880
CB
LEU
A
409
122.640
91.665
66.889
1.00
41.40
6

ATOM
1881
CG
LEU
A
409
121.760
92.653
67.667
1.00
42.57
6

ATOM
1882
CD1
LEU
A
409
122.310
94.062
67.555
1.00
41.86
6

ATOM
1883
CD2
LEU
A
409
120.318
92.609
67.173
1.00
42.68
6

ATOM
1884
C
LEU
A
409
123.275
89.392
66.072
1.00
40.68
6

ATOM
1885
O
LEU
A
409
124.322
88.915
66.473
1.00
40.72
8

ATOM
1886
N
TRP
A
410
122.839
89.292
64.840
1.00
40.78
7

ATOM
1887
CA
TRP
A
410
123.626
88.600
63.867
1.00
39.67
6

ATOM
1888
CB
TRP
A
410
123.036
87.237
63.547
1.00
38.34
6

ATOM
1889
CG
TRP
A
410
123.524
86.178
64.454
1.00
35.21
6

ATOM
1890
CD2
TRP
A
410
122.808
85.616
65.560
1.00
35.72
6

ATOM
1891
CE2
TRP
A
410
123.658
84.659
66.163
1.00
34.68
6

ATOM
1892
CE3
TRP
A
410
121.534
85.828
66.103
1.00
35.54
6

ATOM
1893
CD1
TRP
A
410
124.740
85.560
64.430
1.00
34.64
6

ATOM
1894
NE1
TRP
A
410
124.828
84.646
65.452
1.00
35.22
7

ATOM
1895
CZ2
TRP
A
410
123.274
83.912
67.285
1.00
35.15
6

ATOM
1896
CZ3
TRP
A
410
121.152
85.085
67.222
1.00
36.56
6

ATOM
1897
CH2
TRP
A
410
122.022
84.138
67.801
1.00
35.91
6

ATOM
1898
C
TRP
A
410
123.594
89.432
62.637
1.00
39.35
6

ATOM
1899
O
TRP
A
410
124.597
89.960
62.168
1.00
39.93
8

ATOM
1900
N
ASN
A
411
122.406
89.531
62.137
1.00
39.32
7

ATOM
1901
CA
ASN
A
411
122.266
90.219
60.902
1.00
41.98
6

ATOM
1902
CB
ASN
A
411
122.567
91.680
61.016
1.00
44.32
6

ATOM
1903
CG
ASN
A
411
121.555
92.308
61.895
1.00
47.64
6

ATOM
1904
OD1
ASN
A
411
121.449
91.971
63.062
1.00
50.47
8

ATOM
1905
ND2
ASN
A
411
120.793
93.240
61.354
1.00
48.74
7

ATOM
1906
C
ASN
A
411
123.221
89.584
59.975
1.00
40.86
6

ATOM
1907
O
ASN
A
411
124.329
90.031
59.685
1.00
41.14
8

ATOM
1908
N
VAL
A
412
122.698
88.477
59.540
1.00
40.98
7

ATOM
1909
CA
VAL
A
412
123.397
87.656
58.631
1.00
41.10
6

ATOM
1910
CB
VAL
A
412
124.250
86.610
59.359
1.00
43.78
6

ATOM
1911
CG1
VAL
A
412
124.947
85.712
58.347
1.00
44.32
6

ATOM
1912
CG2
VAL
A
412
125.270
87.264
60.278
1.00
46.04
6

ATOM
1913
C
VAL
A
412
122.410
86.925
57.738
1.00
39.81
6

ATOM
1914
O
VAL
A
412
121.390
86.386
58.179
1.00
39.00
8

ATOM
1915
N
TRP
A
413
122.750
86.925
56.485
1.00
37.64
7

ATOM
1916
CA
TRP
A
413
121.929
86.216
55.510
1.00
37.95
6

ATOM
1917
CB
TRP
A
413
122.215
86.692
54.083
1.00
36.04
6

ATOM
1918
CG
TRP
A
413
121.594
88.000
53.711
1.00
36.62
6

ATOM
1919
CD2
TRP
A
413
120.210
88.247
53.444
1.00
35.86
6

ATOM
1920
CE2
TRP
A
413
120.085
89.614
53.118
1.00
37.12
6

ATOM
1921
CE3
TRP
A
413
119.064
87.445
53.449
1.00
36.57
6

ATOM
1922
CD1
TRP
A
413
122.236
89.197
53.540
1.00
37.75
6

ATOM
1923
NE1
TRP
A
413
121.336
90.170
53.183
1.00
36.62
7

ATOM
1924
CZ2
TRP
A
413
118.858
90.199
52.799
1.00
37.73
6

ATOM
1925
CZ3
TRP
A
413
117.842
88.026
53.132
1.00
38.34
6

ATOM
1926
CH2
TRP
A
413
117.749
89.391
52.813
1.00
38.59
6

ATOM
1927
C
TRP
A
413
122.242
84.727
55.578
1.00
38.27
6

ATOM
1928
O
TRP
A
413
123.410
84.333
55.609
1.00
39.21
8

ATOM
1929
N
LEU
A
414
121.200
83.905
55.623
1.00
39.34
7

ATOM
1930
CA
LEU
A
414
121.364
82.455
55.627
1.00
39.63
6

ATOM
1931
CB
LEU
A
414
120.519
81.804
56.725
1.00
38.33
6

ATOM
1932
CG
LEU
A
414
120.941
82.040
58.177
1.00
39.08
6

ATOM
1933
CD1
LEU
A
414
120.055
81.217
59.092
1.00
35.65
6

ATOM
1934
CD2
LEU
A
414
122.414
81.654
58.372
1.00
36.45
6

ATOM
1935
C
LEU
A
414
120.840
82.046
54.259
1.00
41.16
6

ATOM
1936
O
LEU
A
414
119.647
82.180
53.989
1.00
41.85
8

ATOM
1937
N
GLU
A
415
121.729
81.577
53.387
1.00
42.52
7

ATOM
1938
CA
GLU
A
415
121.326
81.187
52.042
1.00
42.42
6

ATOM
1939
CB
GLU
A
415
122.293
81.767
51.014
1.00
44.14
6

ATOM
1940
CG
GLU
A
415
121.856
81.528
49.581
1.00
46.84
6

ATOM
1941
CD
GLU
A
415
122.688
82.307
48.583
1.00
49.89
6

ATOM
1942
OE1
GLU
A
415
123.886
81.985
48.415
1.00
50.42
8

ATOM
1943
OE2
GLU
A
415
122.141
83.251
47.973
1.00
50.86
8

ATOM
1944
C
GLU
A
415
121.224
79.682
51.854
1.00
43.07
6

ATOM
1945
O
GLU
A
415
122.127
78.930
52.225
1.00
43.39
8

ATOM
1946
N
PHE
A
416
120.114
79.224
51.263
1.00
43.16
7

ATOM
1947
CA
PHE
A
416
119.863
77.809
51.028
1.00
44.50
6

ATOM
1948
CB
PHE
A
416
118.385
77.497
51.397
1.00
42.87
6

ATOM
1949
CG
PHE
A
416
118.078
77.783
52.834
1.00
43.14
6

ATOM
1950
CD1
PHE
A
416
117.940
79.094
53.283
1.00
42.19
6

ATOM
1951
CD2
PHE
A
416
117.940
76.745
53.748
1.00
40.55
6

ATOM
1952
CE1
PHE
A
416
117.673
79.363
54.626
1.00
41.92
6

ATOM
1953
CE2
PHE
A
416
117.673
77.005
55.091
1.00
41.15
6

ATOM
1954
CZ
PHE
A
416
117.542
78.316
55.529
1.00
39.46
6

ATOM
1955
C
PHE
A
416
120.200
77.346
49.611
1.00
45.13
6

ATOM
1956
O
PHE
A
416
120.489
78.166
48.727
1.00
44.88
8

ATOM
1957
N
SER
A
417
120.159
76.047
49.412
1.00
45.55
7

ATOM
1958
CA
SER
A
417
120.439
75.427
48.121
1.00
46.85
6

ATOM
1959
CB
SER
A
417
120.841
73.954
48.302
1.00
47.92
6

ATOM
1960
OG
SER
A
417
119.843
73.250
49.019
1.00
52.74
8

ATOM
1961
C
SER
A
417
119.219
75.473
47.247
1.00
44.96
6

ATOM
1962
O
SER
A
417
119.262
75.377
46.027
1.00
46.34
8

ATOM
1963
N
ILE
A
418
118.145
75.640
47.947
1.00
42.56
7

ATOM
1964
CA
ILE
A
418
116.852
75.654
47.342
1.00
38.93
6

ATOM
1965
CB
ILE
A
418
115.817
75.434
48.425
1.00
39.56
6

ATOM
1966
CG2
ILE
A
418
114.431
75.275
47.845
1.00
39.65
6

ATOM
1967
CG1
ILE
A
418
116.204
74.194
49.219
1.00
42.20
6

ATOM
1968
CD1
ILE
A
418
115.040
73.489
49.863
1.00
44.49
6

ATOM
1969
C
ILE
A
418
116.549
76.884
46.557
1.00
37.83
6

ATOM
1970
O
ILE
A
418
116.855
78.012
46.941
1.00
36.31
8

ATOM
1971
N
LYS
A
419
115.940
76.598
45.435
1.00
34.70
7

ATOM
1972
CA
LYS
A
419
115.472
77.622
44.574
1.00
34.79
6

ATOM
1973
CB
LYS
A
419
115.507
77.200
43.106
1.00
33.82
6

ATOM
1974
CG
LYS
A
419
116.892
76.809
42.612
1.00
37.02
6

ATOM
1975
CD
LYS
A
419
116.914
76.613
41.108
1.00
37.07
6

ATOM
1976
CE
LYS
A
419
118.339
76.555
40.577
1.00
38.11
6

ATOM
1977
NZ
LYS
A
419
118.392
76.669
39.093
1.00
41.00
7

ATOM
1978
C
LYS
A
419
114.051
77.975
44.984
1.00
35.62
6

ATOM
1979
O
LYS
A
419
113.258
77.100
45.361
1.00
34.14
8

ATOM
1980
N
ILE
A
420
113.734
79.259
44.886
1.00
35.91
7

ATOM
1981
CA
ILE
A
420
112.412
79.761
45.236
1.00
36.91
6

ATOM
1982
CB
ILE
A
420
112.279
81.262
44.884
1.00
35.83
6

ATOM
1983
CG2
ILE
A
420
110.873
81.744
45.187
1.00
35.04
6

ATOM
1984
CG1
ILE
A
420
113.327
82.071
45.644
1.00
38.85
6

ATOM
1985
CD1
ILE
A
420
113.192
82.005
47.153
1.00
40.77
6

ATOM
1986
C
ILE
A
420
111.334
78.991
44.483
1.00
36.51
6

ATOM
1987
O
ILE
A
420
110.290
78.647
45.040
1.00
37.31
8

ATOM
1988
N
LYS
A
421
111.596
78.734
43.209
1.00
36.28
7

ATOM
1989
CA
LYS
A
421
110.661
78.017
42.359
1.00
37.18
6

ATOM
1990
CB
LYS
A
421
111.237
77.916
40.942
1.00
39.99
6

ATOM
1991
CG
LYS
A
421
110.267
77.414
39.891
1.00
43.60
6

ATOM
1992
CD
LYS
A
421
109.189
78.458
39.576
1.00
47.47
6

ATOM
1993
CE
LYS
A
421
108.334
78.045
38.372
1.00
47.74
6

ATOM
1994
NZ
LYS
A
421
107.260
79.046
38.091
1.00
50.10
7

ATOM
1995
C
LYS
A
421
110.399
76.614
42.903
1.00
35.84
6

ATOM
1996
O
LYS
A
421
109.345
76.028
42.653
1.00
37.27
8

ATOM
1997
N
ASP
A
422
111.364
76.080
43.647
1.00
34.27
7

ATOM
1998
CA
ASP
A
422
111.254
74.734
44.203
1.00
32.80
6

ATOM
1999
CB
ASP
A
422
112.644
74.101
44.295
1.00
32.04
6

ATOM
2000
CG
ASP
A
422
113.176
73.670
42.936
1.00
34.49
6

ATOM
2001
OD1
ASP
A
422
112.395
73.055
42.180
1.00
34.95
8

ATOM
2002
OD2
ASP
A
422
114.363
73.931
42.628
1.00
33.45
8

ATOM
2003
C
ASP
A
422
110.537
74.608
45.550
1.00
31.18
6

ATOM
2004
O
ASP
A
422
110.361
73.496
46.059
1.00
28.58
8

ATOM
2005
N
LEU
A
423
110.117
75.734
46.115
1.00
30.39
7

ATOM
2006
CA
LEU
A
423
109.411
75.720
47.393
1.00
29.32
6

ATOM
2007
CB
LEU
A
423
109.322
77.135
47.978
1.00
29.35
6

ATOM
2008
CG
LEU
A
423
110.651
77.738
48.446
1.00
32.26
6

ATOM
2009
CD1
LEU
A
423
110.424
79.150
48.985
1.00
30.48
6

ATOM
2010
CD2
LEU
A
423
111.261
76.859
49.530
1.00
31.11
6

ATOM
2011
C
LEU
A
423
108.016
75.134
47.221
1.00
28.48
6

ATOM
2012
O
LEU
A
423
107.171
75.698
46.527
1.00
31.21
8

ATOM
2013
N
PRO
A
424
107.760
73.976
47.849
1.00
28.80
7

ATOM
2014
CD
PRO
A
424
108.689
73.196
48.691
1.00
27.10
6

ATOM
2015
CA
PRO
A
424
106.453
73.318
47.755
1.00
28.99
6

ATOM
2016
CB
PRO
A
424
106.755
71.900
48.215
1.00
28.81
6

ATOM
2017
CG
PRO
A
424
107.773
72.135
49.312
1.00
29.32
6

ATOM
2018
C
PRO
A
424
105.424
74.002
48.648
1.00
28.92
6

ATOM
2019
O
PRO
A
424
105.746
74.427
49.754
1.00
28.30
8

ATOM
2020
N
LYS
A
425
104.190
74.117
48.174
1.00
29.87
7

ATOM
2021
CA
LYS
A
425
103.161
74.738
48.986
1.00
32.47
6

ATOM
2022
CB
LYS
A
425
101.801
74.709
48.287
1.00
34.55
6

ATOM
2023
CG
LYS
A
425
100.707
75.409
49.104
1.00
38.26
6

ATOM
2024
CD
LYS
A
425
99.312
75.289
48.500
1.00
39.70
6

ATOM
2025
CE
LYS
A
425
98.309
76.052
49.369
1.00
41.40
6

ATOM
2026
NZ
LYS
A
425
96.896
75.917
48.915
1.00
40.74
7

ATOM
2027
C
LYS
A
425
103.091
73.924
50.277
1.00
32.44
6

ATOM
2028
O
LYS
A
425
103.188
72.696
50.250
1.00
31.50
8

ATOM
2029
N
GLY
A
426
102.940
74.614
51.400
1.00
31.94
7

ATOM
2030
CA
GLY
A
426
102.865
73.935
52.682
1.00
30.15
6

ATOM
2031
C
GLY
A
426
104.210
73.889
53.373
1.00
30.43
6

ATOM
2032
O
GLY
A
426
104.334
73.399
54.501
1.00
30.37
8

ATOM
2033
N
ALA
A
427
105.228
74.398
52.687
1.00
28.41
7

ATOM
2034
CA
ALA
A
427
106.571
74.424
53.237
1.00
28.07
6

ATOM
2035
CB
ALA
A
427
107.561
74.916
52.182
1.00
29.08
6

ATOM
2036
C
ALA
A
427
106.613
75.348
54.441
1.00
26.40
6

ATOM
2037
O
ALA
A
427
105.970
76.399
54.437
1.00
23.37
8

ATOM
2038
N
LEU
A
428
107.369
74.948
55.463
1.00
24.40
7

ATOM
2039
CA
LEU
A
428
107.537
75.744
56.676
1.00
24.90
6

ATOM
2040
CB
LEU
A
428
107.180
74.940
57.926
1.00
24.99
6

ATOM
2041
CG
LEU
A
428
105.739
74.646
58.315
1.00
24.59
6

ATOM
2042
CD1
LEU
A
428
105.726
73.872
59.631
1.00
25.87
6

ATOM
2043
CD2
LEU
A
428
104.989
75.960
58.439
1.00
24.90
6

ATOM
2044
C
LEU
A
428
108.975
76.190
56.875
1.00
26.32
6

ATOM
2045
O
LEU
A
428
109.908
75.418
56.623
1.00
27.28
8

ATOM
2046
N
LEU
A
429
109.160
77.433
57.307
1.00
23.04
7

ATOM
2047
CA
LEU
A
429
110.494
77.884
57.653
1.00
24.19
6

ATOM
2048
CB
LEU
A
429
110.719
79.370
57.356
1.00
23.52
6

ATOM
2049
CG
LEU
A
429
112.028
79.888
57.983
1.00
23.76
6

ATOM
2050
CD1
LEU
A
429
113.212
79.151
57.357
1.00
22.16
6

ATOM
2051
CD2
LEU
A
429
112.188
81.399
57.785
1.00
22.26
6

ATOM
2052
C
LEU
A
429
110.492
77.679
59.172
1.00
24.77
6

ATOM
2053
O
LEU
A
429
109.832
78.426
59.903
1.00
24.51
8

ATOM
2054
N
ASN
A
430
111.196
76.657
59.639
1.00
24.85
7

ATOM
2055
CA
ASN
A
430
111.279
76.356
61.068
1.00
25.15
6

ATOM
2056
CB
ASN
A
430
111.329
74.828
61.252
1.00
26.25
6

ATOM
2057
CG
ASN
A
430
111.692
74.404
62.659
1.00
27.16
6

ATOM
2058
OD1
ASN
A
430
112.850
74.082
62.939
1.00
29.96
8

ATOM
2059
ND2
ASN
A
430
110.704
74.389
63.557
1.00
25.59
7

ATOM
2060
C
ASN
A
430
112.525
77.037
61.651
1.00
26.13
6

ATOM
2061
O
ASN
A
430
113.633
76.857
61.142
1.00
26.42
8

ATOM
2062
N
LEU
A
431
112.341
77.833
62.703
1.00
22.85
7

ATOM
2063
CA
LEU
A
431
113.455
78.555
63.317
1.00
22.51
6

ATOM
2064
CB
LEU
A
431
113.202
80.062
63.267
1.00
22.56
6

ATOM
2065
CG
LEU
A
431
113.018
80.678
61.872
1.00
23.30
6

ATOM
2066
CD1
LEU
A
431
112.410
82.071
62.025
1.00
22.19
6

ATOM
2067
CD2
LEU
A
431
114.367
80.760
61.127
1.00
22.68
6

ATOM
2068
C
LEU
A
431
113.625
78.113
64.759
1.00
23.68
6

ATOM
2069
O
LEU
A
431
112.684
78.151
65.548
1.00
22.30
8

ATOM
2070
N
GLN
A
432
114.836
77.710
65.113
1.00
25.65
7

ATOM
2071
CA
GLN
A
432
115.068
77.238
66.464
1.00
24.30
6

ATOM
2072
CB
GLN
A
432
115.110
75.701
66.459
1.00
25.96
6

ATOM
2073
CG
GLN
A
432
113.728
75.109
66.179
1.00
26.25
6

ATOM
2074
CD
GLN
A
432
113.699
73.600
66.053
1.00
26.28
6

ATOM
2075
OE1
GLN
A
432
112.644
72.999
66.179
1.00
29.03
8

ATOM
2076
NE2
GLN
A
432
114.844
72.987
65.781
1.00
29.91
7

ATOM
2077
C
GLN
A
432
116.299
77.826
67.124
1.00
25.76
6

ATOM
2078
O
GLN
A
432
117.271
78.195
66.463
1.00
25.83
8

ATOM
2079
N
ILE
A
433
116.234
77.930
68.445
1.00
25.41
7

ATOM
2080
CA
ILE
A
433
117.331
78.483
69.209
1.00
29.08
6

ATOM
2081
CB
ILE
A
433
116.862
79.708
70.016
1.00
30.56
6

ATOM
2082
CG2
ILE
A
433
118.024
80.309
70.785
1.00
32.44
6

ATOM
2083
CG1
ILE
A
433
116.280
80.757
69.058
1.00
30.98
6

ATOM
2084
CD1
ILE
A
433
115.875
82.044
69.744
1.00
35.38
6

ATOM
2085
C
ILE
A
433
117.884
77.408
70.134
1.00
30.49
6

ATOM
2086
O
ILE
A
433
117.152
76.820
70.937
1.00
30.63
8

ATOM
2087
N
TYR
A
434
119.176
77.141
69.983
1.00
33.94
7

ATOM
2088
CA
TYR
A
434
119.875
76.141
70.781
1.00
35.52
6

ATOM
2089
CB
TYR
A
434
120.702
75.229
69.866
1.00
34.69
6

ATOM
2090
CG
TYR
A
434
119.869
74.277
69.037
1.00
33.73
6

ATOM
2091
CD1
TYR
A
434
119.451
73.053
69.552
1.00
33.37
6

ATOM
2092
CE1
TYR
A
434
118.662
72.178
68.792
1.00
34.14
6

ATOM
2093
CD2
TYR
A
434
119.478
74.612
67.739
1.00
33.83
6

ATOM
2094
CE2
TYR
A
434
118.694
73.753
66.978
1.00
33.17
6

ATOM
2095
CZ
TYR
A
434
118.290
72.543
67.505
1.00
33.50
6

ATOM
2096
OH
TYR
A
434
117.507
71.707
66.751
1.00
36.20
8

ATOM
2097
C
TYR
A
434
120.789
76.825
71.792
1.00
37.82
6

ATOM
2098
O
TYR
A
434
121.382
77.856
71.498
1.00
36.48
8

ATOM
2099
N
CYS
A
435
120.889
76.240
72.982
1.00
40.03
7

ATOM
2100
CA
CYS
A
435
121.718
76.789
74.049
1.00
45.88
6

ATOM
2101
CB
CYS
A
435
120.831
77.289
75.192
1.00
48.29
6

ATOM
2102
SG
CYS
A
435
121.716
78.102
76.547
1.00
57.50
16

ATOM
2103
C
CYS
A
435
122.673
75.728
74.577
1.00
45.55
6

ATOM
2104
O
CYS
A
435
122.280
74.573
74.749
1.00
48.00
8

ATOM
2105
N
LYS
A
457
126.651
69.079
74.729
1.00
20.00
7

ATOM
2106
CA
LYS
A
457
125.487
69.039
73.861
1.00
20.00
6

ATOM
2107
C
LYS
A
457
125.386
70.312
73.034
1.00
20.00
6

ATOM
2108
O
LYS
A
457
126.215
71.250
73.319
1.00
20.00
8

ATOM
2109
CB
LYS
A
457
124.222
68.813
74.687
1.00
20.00
6

ATOM
2110
CG
LYS
A
457
124.219
67.503
75.459
1.00
20.00
6

ATOM
2111
CD
LYS
A
457
122.859
67.228
76.075
1.00
20.00
6

ATOM
2112
CE
LYS
A
457
122.860
65.921
76.853
1.00
20.00
6

ATOM
2113
NZ
LYS
A
457
121.532
65.633
77.459
1.00
20.00
7

ATOM
2114
N
VAL
A
458
124.220
70.143
72.413
1.00
20.00
7

ATOM
2115
CA
VAL
A
458
123.249
70.806
71.584
1.00
20.00
6

ATOM
2116
C
VAL
A
458
121.986
71.019
72.477
1.00
20.00
6

ATOM
2117
O
VAL
A
458
121.635
70.115
73.222
1.00
20.00
8

ATOM
2118
CB
VAL
A
458
122.794
69.850
70.442
1.00
20.00
6

ATOM
2119
CG1
VAL
A
458
122.530
70.626
69.168
1.00
20.00
6

ATOM
2120
CG2
VAL
A
458
123.835
68.764
70.201
1.00
20.00
6

ATOM
2121
N
ARG
A
459
121.303
72.150
72.428
1.00
20.00
7

ATOM
2122
CA
ARG
A
459
120.049
72.190
73.191
1.00
20.00
6

ATOM
2123
C
ARG
A
459
119.091
73.224
72.627
1.00
20.00
6

ATOM
2124
O
ARG
A
459
119.417
74.382
72.431
1.00
20.00
8

ATOM
2125
CB
ARG
A
459
120.297
72.310
74.702
1.00
20.00
6

ATOM
2126
CG
ARG
A
459
120.752
71.006
75.381
1.00
20.00
6

ATOM
2127
CD
ARG
A
459
119.953
70.557
76.630
1.00
20.00
6

ATOM
2128
NE
ARG
A
459
120.660
69.508
77.397
1.00
20.00
7

ATOM
2129
CZ
ARG
A
459
120.307
69.029
78.593
1.00
20.00
6

ATOM
2130
NH1
ARG
A
459
119.227
69.478
79.218
1.00
20.00
7

ATOM
2131
NH2
ARG
A
459
121.065
68.101
79.162
1.00
20.00
7

ATOM
2132
N
LEU
A
460
117.909
72.731
72.364
1.00
43.17
7

ATOM
2133
CA
LEU
A
460
116.809
73.500
71.819
1.00
41.32
6

ATOM
2134
CB
LEU
A
460
115.884
72.595
70.998
1.00
40.23
6

ATOM
2135
CG
LEU
A
460
114.649
73.239
70.353
1.00
39.58
6

ATOM
2136
CD1
LEU
A
460
115.042
74.283
69.308
1.00
35.51
6

ATOM
2137
CD2
LEU
A
460
113.778
72.160
69.727
1.00
37.87
6

ATOM
2138
C
LEU
A
460
116.014
74.149
72.955
1.00
40.53
6

ATOM
2139
O
LEU
A
460
115.479
73.457
73.825
1.00
41.80
8

ATOM
2140
N
LEU
A
461
115.939
75.476
72.937
1.00
38.69
7

ATOM
2141
CA
LEU
A
461
115.210
76.225
73.958
1.00
35.79
6

ATOM
2142
CB
LEU
A
461
116.097
77.323
74.554
1.00
38.17
6

ATOM
2143
CG
LEU
A
461
117.311
76.920
75.389
1.00
40.60
6

ATOM
2144
CD1
LEU
A
461
117.865
78.161
76.076
1.00
41.76
6

ATOM
2145
CD2
LEU
A
461
116.907
75.876
76.425
1.00
42.07
6

ATOM
2146
C
LEU
A
461
113.932
76.877
73.432
1.00
32.67
6

ATOM
2147
O
LEU
A
461
112.959
77.031
74.168
1.00
29.28
8

ATOM
2148
N
TYR
A
462
113.940
77.267
72.162
1.00
29.97
7

ATOM
2149
CA
TYR
A
462
112.782
77.933
71.572
1.00
27.52
6

ATOM
2150
CB
TYR
A
462
112.957
79.455
71.607
1.00
24.52
6

ATOM
2151
CG
TYR
A
462
113.228
80.040
72.974
1.00
27.06
6

ATOM
2152
CD1
TYR
A
462
112.188
80.377
73.837
1.00
26.78
6

ATOM
2153
CE1
TYR
A
462
112.453
80.889
75.116
1.00
27.50
6

ATOM
2154
CD2
TYR
A
462
114.535
80.229
73.415
1.00
27.33
6

ATOM
2155
CE2
TYR
A
462
114.807
80.731
74.678
1.00
27.86
6

ATOM
2156
CZ
TYR
A
462
113.771
81.059
75.526
1.00
28.84
6

ATOM
2157
OH
TYR
A
462
114.073
81.541
76.793
1.00
31.44
8

ATOM
2158
C
TYR
A
462
112.618
77.529
70.118
1.00
26.40
6

ATOM
2159
O
TYR
A
462
113.588
77.164
69.451
1.00
26.10
8

ATOM
2160
N
TYR
A
463
111.388
77.635
69.632
1.00
23.46
7

ATOM
2161
CA
TYR
A
463
111.085
77.328
68.244
1.00
22.49
6

ATOM
2162
CB
TYR
A
463
110.766
75.834
68.074
1.00
21.60
6

ATOM
2163
CG
TYR
A
463
109.440
75.405
68.657
1.00
23.47
6

ATOM
2164
CD1
TYR
A
463
108.265
75.462
67.894
1.00
22.63
6

ATOM
2165
CE1
TYR
A
463
107.040
75.073
68.431
1.00
21.14
6

ATOM
2166
CD2
TYR
A
463
109.347
74.950
69.971
1.00
22.36
6

ATOM
2167
CE2
TYR
A
463
108.124
74.562
70.515
1.00
22.49
6

ATOM
2168
CZ
TYR
A
463
106.978
74.630
69.735
1.00
21.04
6

ATOM
2169
OH
TYR
A
463
105.778
74.261
70.275
1.00
23.91
8

ATOM
2170
C
TYR
A
463
109.888
78.146
67.807
1.00
20.40
6

ATOM
2171
O
TYR
A
463
109.080
78.595
68.627
1.00
21.37
8

ATOM
2172
N
VAL
A
464
109.788
78.357
66.508
1.00
19.74
7

ATOM
2173
CA
VAL
A
464
108.653
79.062
65.944
1.00
19.17
6

ATOM
2174
CB
VAL
A
464
108.752
80.591
66.120
1.00
18.10
6

ATOM
2175
CG1
VAL
A
464
109.804
81.169
65.177
1.00
18.04
6

ATOM
2176
CG2
VAL
A
464
107.385
81.226
65.837
1.00
18.80
6

ATOM
2177
C
VAL
A
464
108.696
78.717
64.468
1.00
19.31
6

ATOM
2178
O
VAL
A
464
109.772
78.478
63.921
1.00
20.14
8

ATOM
2179
N
ASN
A
465
107.534
78.681
63.831
1.00
19.75
7

ATOM
2180
CA
ASN
A
465
107.454
78.349
62.415
1.00
20.03
6

ATOM
2181
CB
ASN
A
465
106.680
77.052
62.224
1.00
21.26
6

ATOM
2182
CG
ASN
A
465
107.296
75.891
62.965
1.00
23.37
6

ATOM
2183
OD1
ASN
A
465
108.472
75.564
62.773
1.00
22.27
8

ATOM
2184
ND2
ASN
A
465
106.496
75.245
63.816
1.00
24.07
7

ATOM
2185
C
ASN
A
465
106.732
79.435
61.647
1.00
22.95
6

ATOM
2186
O
ASN
A
465
105.954
80.186
62.217
1.00
24.87
8

ATOM
2187
N
LEU
A
466
106.976
79.489
60.343
1.00
24.46
7

ATOM
2188
CA
LEU
A
466
106.332
80.461
59.455
1.00
25.68
6

ATOM
2189
CB
LEU
A
466
107.234
81.687
59.256
1.00
25.27
6

ATOM
2190
CG
LEU
A
466
106.817
82.721
58.207
1.00
29.13
6

ATOM
2191
CD1
LEU
A
466
105.563
83.468
58.670
1.00
27.35
6

ATOM
2192
CD2
LEU
A
466
107.967
83.696
57.977
1.00
27.46
6

ATOM
2193
C
LEU
A
466
106.105
79.780
58.114
1.00
23.55
6

ATOM
2194
O
LEU
A
466
107.044
79.239
57.534
1.00
23.34
8

ATOM
2195
N
LEU
A
467
104.867
79.786
57.633
1.00
24.66
7

ATOM
2196
CA
LEU
A
467
104.561
79.176
56.342
1.00
26.32
6

ATOM
2197
CB
LEU
A
467
103.044
79.143
56.120
1.00
27.18
6

ATOM
2198
CG
LEU
A
467
102.233
78.007
56.766
1.00
26.69
6

ATOM
2199
CD1
LEU
A
467
100.785
78.455
56.932
1.00
24.55
6

ATOM
2200
CD2
LEU
A
467
102.314
76.746
55.907
1.00
24.63
6

ATOM
2201
C
LEU
A
467
105.238
80.027
55.269
1.00
29.39
6

ATOM
2202
O
LEU
A
467
105.011
81.239
55.200
1.00
28.78
8

ATOM
2203
N
LEU
A
468
106.078
79.402
54.448
1.00
28.07
7

ATOM
2204
CA
LEU
A
468
106.786
80.128
53.404
1.00
29.90
6

ATOM
2205
CB
LEU
A
468
107.924
79.275
52.841
1.00
30.56
6

ATOM
2206
CG
LEU
A
468
109.175
79.247
53.717
1.00
29.84
6

ATOM
2207
CD1
LEU
A
468
110.238
78.397
53.057
1.00
33.07
6

ATOM
2208
CD2
LEU
A
468
109.694
80.667
53.918
1.00
30.28
6

ATOM
2209
C
LEU
A
468
105.860
80.586
52.285
1.00
29.24
6

ATOM
2210
O
LEU
A
468
106.065
81.649
51.704
1.00
32.99
8

ATOM
2211
N
ILE
A
469
104.875
79.754
52.002
1.00
26.73
7

ATOM
2212
CA
ILE
A
469
103.921
80.044
50.979
1.00
28.57
6

ATOM
2213
CB
ILE
A
469
103.821
78.926
49.929
1.00
29.79
6

ATOM
2214
CG2
ILE
A
469
102.662
79.169
48.968
1.00
29.69
6

ATOM
2215
CG1
ILE
A
469
105.134
78.876
49.169
1.00
32.72
6

ATOM
2216
CD1
ILE
A
469
105.223
77.746
48.165
1.00
35.64
6

ATOM
2217
C
ILE
A
469
102.610
80.218
51.675
1.00
28.28
6

ATOM
2218
O
ILE
A
469
102.192
79.372
52.451
1.00
25.93
8

ATOM
2219
N
ASP
A
470
101.958
81.319
51.412
1.00
28.05
7

ATOM
2220
CA
ASP
A
470
100.708
81.451
52.064
1.00
31.36
6

ATOM
2221
CB
ASP
A
470
100.231
82.899
52.096
1.00
31.62
6

ATOM
2222
CG
ASP
A
470
100.141
83.509
50.741
1.00
32.80
6

ATOM
2223
OD1
ASP
A
470
100.045
82.747
49.751
1.00
29.25
8

ATOM
2224
OD2
ASP
A
470
100.149
84.753
50.642
1.00
35.14
8

ATOM
2225
C
ASP
A
470
99.703
80.542
51.434
1.00
32.37
6

ATOM
2226
O
ASP
A
470
100.026
79.525
50.819
1.00
30.74
8

ATOM
2227
N
HIS
A
471
98.461
80.911
51.619
1.00
32.41
7

ATOM
2228
CA
HIS
A
471
97.329
80.129
51.186
1.00
33.88
6

ATOM
2229
CB
HIS
A
471
96.165
80.415
52.106
1.00
35.21
6

ATOM
2230
CG
HIS
A
471
96.004
81.920
52.408
1.00
33.30
6

ATOM
2231
CD2
HIS
A
471
94.892
82.666
52.352
1.00
32.78
6

ATOM
2232
ND1
HIS
A
471
97.002
82.748
52.841
1.00
34.03
7

ATOM
2233
CE1
HIS
A
471
96.505
83.964
53.058
1.00
33.97
6

ATOM
2234
NE2
HIS
A
471
95.224
83.920
52.769
1.00
30.29
7

ATOM
2235
C
HIS
A
471
96.934
80.331
49.747
1.00
34.98
6

ATOM
2236
O
HIS
A
471
96.657
79.364
49.038
1.00
33.12
8

ATOM
2237
N
ARG
A
472
96.905
81.578
49.316
1.00
36.54
7

ATOM
2238
CA
ARG
A
472
96.585
81.750
47.924
1.00
39.87
6

ATOM
2239
CB
ARG
A
472
96.291
83.187
47.610
1.00
40.05
6

ATOM
2240
CG
ARG
A
472
96.666
84.052
48.781
1.00
41.54
6

ATOM
2241
CD
ARG
A
472
96.384
85.477
48.446
1.00
43.55
6

ATOM
2242
NE
ARG
A
472
95.082
85.886
48.902
1.00
46.69
7

ATOM
2243
CZ
ARG
A
472
94.809
86.155
50.168
1.00
46.61
6

ATOM
2244
NH1
ARG
A
472
95.759
86.023
51.079
1.00
45.88
7

ATOM
2245
NH2
ARG
A
472
93.605
86.557
50.527
1.00
46.51
7

ATOM
2246
C
ARG
A
472
98.053
81.462
47.961
1.00
40.61
6

ATOM
2247
O
ARG
A
472
98.703
81.615
48.991
1.00
41.92
8

ATOM
2248
N
PHE
A
473
98.574
81.035
46.839
1.00
40.52
7

ATOM
2249
CA
PHE
A
473
99.943
80.730
46.950
1.00
40.97
6

ATOM
2250
CB
PHE
A
473
99.286
80.277
45.639
1.00
42.48
6

ATOM
2251
CG
PHE
A
473
98.325
79.106
45.836
1.00
44.36
6

ATOM
2252
CD1
PHE
A
473
97.052
79.185
46.420
1.00
45.70
6

ATOM
2253
CD2
PHE
A
473
98.779
77.888
45.404
1.00
45.18
6

ATOM
2254
CE1
PHE
A
473
96.272
78.035
46.510
1.00
46.58
6

ATOM
2255
CE2
PHE
A
473
98.006
76.763
45.489
1.00
45.41
6

ATOM
2256
CZ
PHE
A
473
96.735
76.821
46.042
1.00
45.03
6

ATOM
2257
C
PHE
A
473
100.933
81.888
46.805
1.00
39.14
6

ATOM
2258
O
PHE
A
473
101.658
81.974
45.820
1.00
39.66
8

ATOM
2259
N
LEU
A
474
100.969
82.791
47.812
1.00
38.07
7

ATOM
2260
CA
LEU
A
474
101.956
83.853
47.677
1.00
37.13
6

ATOM
2261
CB
LEU
A
474
101.317
85.208
47.991
1.00
38.77
6

ATOM
2262
CG
LEU
A
474
100.047
85.535
47.201
1.00
41.22
6

ATOM
2263
CD1
LEU
A
474
99.567
86.940
47.544
1.00
42.37
6

ATOM
2264
CD2
LEU
A
474
100.329
85.413
45.717
1.00
40.84
6

ATOM
2265
C
LEU
A
474
103.147
83.629
48.603
1.00
37.43
6

ATOM
2266
O
LEU
A
474
102.981
83.241
49.756
1.00
36.31
8

ATOM
2267
N
LEU
A
475
104.346
83.885
48.089
1.00
36.57
7

ATOM
2268
CA
LEU
A
475
105.564
83.720
48.864
1.00
35.93
6

ATOM
2269
CB
LEU
A
475
106.796
83.845
47.960
1.00
35.48
6

ATOM
2270
CG
LEU
A
475
108.124
83.670
48.699
1.00
35.75
6

ATOM
2271
CD1
LEU
A
475
108.238
82.220
49.145
1.00
35.01
6

ATOM
2272
CD2
LEU
A
475
109.296
84.047
47.804
1.00
36.22
6

ATOM
2273
C
LEU
A
475
105.645
84.774
49.963
1.00
37.15
6

ATOM
2274
O
LEU
A
475
105.429
85.959
49.713
1.00
37.59
8

ATOM
2275
N
ARG
A
476
105.968
84.341
51.175
1.00
35.70
7

ATOM
2276
CA
ARG
A
476
106.071
85.264
52.294
1.00
36.99
6

ATOM
2277
CB
ARG
A
476
106.423
84.514
53.575
1.00
38.57
6

ATOM
2278
CG
ARG
A
476
105.866
85.158
54.819
1.00
41.21
6

ATOM
2279
CD
ARG
A
476
104.418
85.497
54.610
1.00
43.36
6

ATOM
2280
NE
ARG
A
476
103.529
84.495
55.177
1.00
46.52
7

ATOM
2281
CZ
ARG
A
476
103.207
84.437
56.463
1.00
47.41
6

ATOM
2282
NH1
ARG
A
476
103.698
85.332
57.310
1.00
48.24
7

ATOM
2283
NH2
ARG
A
476
102.406
83.476
56.901
1.00
49.79
7

ATOM
2284
C
ARG
A
476
107.157
86.295
52.005
1.00
36.41
6

ATOM
2285
O
ARG
A
476
108.205
85.957
51.449
1.00
34.53
8

ATOM
2286
N
ARG
A
477
106.915
87.567
52.404
1.00
34.99
7

ATOM
2287
CA
ARG
A
477
107.897
88.608
52.157
1.00
34.81
6

ATOM
2288
CB
ARG
A
477
107.745
89.165
50.741
1.00
37.96
6

ATOM
2289
CG
ARG
A
477
106.492
89.999
50.533
1.00
44.58
6

ATOM
2290
CD
ARG
A
477
106.282
90.312
49.061
1.00
49.78
6

ATOM
2291
NE
ARG
A
477
105.376
89.362
48.424
1.00
53.83
7

ATOM
2292
CZ
ARG
A
477
104.053
89.486
48.414
1.00
55.72
6

ATOM
2293
NH1
ARG
A
477
103.481
90.524
49.009
1.00
55.12
7

ATOM
2294
NH2
ARG
A
477
103.306
88.574
47.809
1.00
54.81
7

ATOM
2295
C
ARG
A
477
107.770
89.725
53.180
1.00
33.77
6

ATOM
2296
O
ARG
A
477
106.706
90.078
53.671
1.00
32.96
8

ATOM
2297
N
GLY
A
478
108.921
90.353
53.507
1.00
33.23
7

ATOM
2298
CA
GLY
A
478
108.918
91.462
54.438
1.00
34.07
6

ATOM
2299
C
GLY
A
478
109.615
91.162
55.741
1.00
33.63
6

ATOM
2300
O
GLY
A
478
110.319
90.152
55.865
1.00
31.69
8

ATOM
2301
N
GLU
A
479
109.430
92.055
56.708
1.00
31.25
7

ATOM
2302
CA
GLU
A
479
110.000
91.932
58.024
1.00
31.23
6

ATOM
2303
CB
GLU
A
479
110.219
93.291
58.694
1.00
32.84
6

ATOM
2304
CG
GLU
A
479
111.130
94.248
57.946
1.00
35.78
6

ATOM
2305
CD
GLU
A
479
112.606
93.910
58.029
1.00
38.07
6

ATOM
2306
OE1
GLU
A
479
112.996
93.116
58.911
1.00
39.74
8

ATOM
2307
OE2
GLU
A
479
113.380
94.450
57.215
1.00
39.32
8

ATOM
2308
C
GLU
A
479
109.070
91.105
58.855
1.00
30.28
6

ATOM
2309
O
GLU
A
479
107.854
91.071
58.653
1.00
31.29
8

ATOM
2310
N
TYR
A
480
109.666
90.458
59.775
1.00
29.09
7

ATOM
2311
CA
TYR
A
480
108.875
89.680
60.652
1.00
28.48
6

ATOM
2312
CB
TYR
A
480
108.674
88.275
60.068
1.00
28.54
6

ATOM
2313
CG
TYR
A
480
107.772
88.253
58.856
1.00
30.36
6

ATOM
2314
CD1
TYR
A
480
108.287
88.380
57.563
1.00
32.03
6

ATOM
2315
CE1
TYR
A
480
107.442
88.372
56.447
1.00
31.90
6

ATOM
2316
CD2
TYR
A
480
106.388
88.105
59.002
1.00
31.14
6

ATOM
2317
CE2
TYR
A
480
105.533
88.131
57.890
1.00
31.42
6

ATOM
2318
CZ
TYR
A
480
106.071
88.267
56.620
1.00
32.20
6

ATOM
2319
OH
TYR
A
480
105.235
88.297
55.527
1.00
35.64
8

ATOM
2320
C
TYR
A
480
109.528
89.681
62.025
1.00
28.29
6

ATOM
2321
O
TYR
A
480
110.747
89.690
62.146
1.00
28.45
8

ATOM
2322
N
VAL
A
481
108.692
89.661
63.058
1.00
27.99
7

ATOM
2323
CA
VAL
A
481
109.092
89.617
64.468
1.00
26.72
6

ATOM
2324
CB
VAL
A
481
108.874
90.972
65.177
1.00
27.39
6

ATOM
2325
CG1
VAL
A
481
109.415
90.922
66.599
1.00
27.27
6

ATOM
2326
CG2
VAL
A
481
109.512
92.115
64.403
1.00
27.85
6

ATOM
2327
C
VAL
A
481
108.237
88.519
65.094
1.00
25.68
6

ATOM
2328
O
VAL
A
481
107.082
88.757
65.461
1.00
21.43
8

ATOM
2329
N
LEU
A
482
108.818
87.334
65.203
1.00
26.79
7

ATOM
2330
CA
LEU
A
482
108.081
86.195
65.714
1.00
25.91
6

ATOM
2331
CB
LEU
A
482
108.374
84.983
64.827
1.00
26.35
6

ATOM
2332
CG
LEU
A
482
108.187
85.278
63.330
1.00
28.44
6

ATOM
2333
CD1
LEU
A
482
108.674
84.100
62.498
1.00
30.49
6

ATOM
2334
CD2
LEU
A
482
106.721
85.569
63.046
1.00
26.52
6

ATOM
2335
C
LEU
A
482
108.330
85.840
67.172
1.00
24.79
6

ATOM
2336
O
LEU
A
482
109.448
85.547
67.564
1.00
25.64
8

ATOM
2337
N
HIS
A
483
107.261
85.845
67.959
1.00
22.33
7

ATOM
2338
CA
HIS
A
483
107.341
85.492
69.373
1.00
24.80
6

ATOM
2339
CB
HIS
A
483
106.195
86.189
70.109
1.00
24.79
6

ATOM
2340
CG
HIS
A
483
106.473
87.640
70.360
1.00
27.16
6

ATOM
2341
CD2
HIS
A
483
106.378
88.717
69.544
1.00
28.54
6

ATOM
2342
ND1
HIS
A
483
107.044
88.098
71.532
1.00
30.66
7

ATOM
2343
CE1
HIS
A
483
107.288
89.392
71.424
1.00
29.55
6

ATOM
2344
NE2
HIS
A
483
106.894
89.792
70.228
1.00
30.38
7

ATOM
2345
C
HIS
A
483
107.290
83.965
69.434
1.00
21.99
6

ATOM
2346
O
HIS
A
483
106.340
83.329
68.963
1.00
22.26
8

ATOM
2347
N
MET
A
484
108.350
83.395
69.991
1.00
23.99
7

ATOM
2348
CA
MET
A
484
108.544
81.947
70.049
1.00
23.89
6

ATOM
2349
CB
MET
A
484
110.044
81.666
69.928
1.00
25.18
6

ATOM
2350
CG
MET
A
484
110.756
82.496
68.864
1.00
20.83
6

ATOM
2351
SD
MET
A
484
112.548
82.223
68.849
1.00
24.86
16

ATOM
2352
CE
MET
A
484
112.616
80.543
68.026
1.00
19.74
6

ATOM
2353
C
MET
A
484
107.992
81.159
71.231
1.00
24.87
6

ATOM
2354
O
MET
A
484
107.636
81.718
72.272
1.00
25.16
8

ATOM
2355
N
TRP
A
485
107.939
79.841
71.050
1.00
24.32
7

ATOM
2356
CA
TRP
A
485
107.460
78.919
72.073
1.00
25.36
6

ATOM
2357
CB
TRP
A
485
106.706
77.754
71.416
1.00
23.42
6

ATOM
2358
CG
TRP
A
485
105.562
78.184
70.549
1.00
21.96
6

ATOM
2359
CD2
TRP
A
485
104.270
78.603
70.991
1.00
21.08
6

ATOM
2360
CE2
TRP
A
485
103.509
78.911
69.839
1.00
21.15
6

ATOM
2361
CE3
TRP
A
485
103.678
78.747
72.254
1.00
22.72
6

ATOM
2362
CD1
TRP
A
485
105.541
78.253
69.179
1.00
20.05
6

ATOM
2363
NE1
TRP
A
485
104.307
78.688
68.748
1.00
21.19
7

ATOM
2364
CZ2
TRP
A
485
102.188
79.355
69.912
1.00
21.65
6

ATOM
2365
CZ3
TRP
A
485
102.359
79.188
72.326
1.00
21.63
6

ATOM
2366
CH2
TRP
A
485
101.631
79.486
71.160
1.00
21.41
6

ATOM
2367
C
TRP
A
485
108.655
78.368
72.860
1.00
24.95
6

ATOM
2368
O
TRP
A
485
109.663
77.975
72.268
1.00
25.32
8

ATOM
2369
N
GLN
A
486
108.556
78.345
74.187
1.00
29.44
7

ATOM
2370
CA
GLN
A
486
109.652
77.824
75.009
1.00
34.03
6

ATOM
2371
CB
GLN
A
486
109.752
78.575
76.349
1.00
36.27
6

ATOM
2372
CG
GLN
A
486
111.008
78.218
77.156
1.00
40.57
6

ATOM
2373
CD
GLN
A
486
111.053
78.841
78.550
1.00
43.44
6

ATOM
2374
OE1
GLN
A
486
110.200
78.569
79.395
1.00
46.41
8

ATOM
2375
NE2
GLN
A
486
112.058
79.670
78.795
1.00
43.21
7

ATOM
2376
C
GLN
A
486
109.441
76.335
75.288
1.00
37.08
6

ATOM
2377
O
GLN
A
486
108.345
75.911
75.653
1.00
36.27
8

ATOM
2378
N
ILE
A
487
110.492
75.543
75.118
1.00
39.95
7

ATOM
2379
CA
ILE
A
487
110.393
74.115
75.370
1.00
45.46
6

ATOM
2380
CB
ILE
A
487
111.398
73.328
74.505
1.00
45.86
6

ATOM
2381
CG2
ILE
A
487
111.607
71.924
75.071
1.00
46.37
6

ATOM
2382
CG1
ILE
A
487
110.886
73.287
73.063
1.00
46.44
6

ATOM
2383
CD1
ILE
A
487
111.585
72.286
72.182
1.00
48.95
6

ATOM
2384
C
ILE
A
487
110.622
73.808
76.846
1.00
49.06
6

ATOM
2385
O
ILE
A
487
111.408
74.481
77.513
1.00
49.80
8

ATOM
2386
N
SER
A
488
109.923
72.796
77.348
1.00
52.78
7

ATOM
2387
CA
SER
A
488
110.036
72.398
78.748
1.00
57.39
6

ATOM
2388
CB
SER
A
488
108.642
72.215
79.351
1.00
58.31
6

ATOM
2389
OG
SER
A
488
107.905
71.242
78.631
1.00
61.32
8

ATOM
2390
C
SER
A
488
110.841
71.111
78.927
1.00
58.99
6

ATOM
2391
O
SER
A
488
110.646
70.138
78.198
1.00
59.80
8

ATOM
2392
N
ASN
A
498
106.283
66.282
68.639
1.00
44.66
7

ATOM
2393
CA
ASN
A
498
104.871
66.463
68.950
1.00
39.90
6

ATOM
2394
CB
ASN
A
498
104.692
66.850
70.418
1.00
41.65
6

ATOM
2395
CG
ASN
A
498
103.240
66.821
70.855
1.00
41.93
6

ATOM
2396
OD1
ASN
A
498
102.836
67.564
71.749
1.00
46.35
8

ATOM
2397
ND2
ASN
A
498
102.451
65.959
70.224
1.00
43.41
7

ATOM
2398
C
ASN
A
498
104.238
67.511
68.041
1.00
35.33
6

ATOM
2399
O
ASN
A
498
104.880
68.410
67.518
1.00
32.74
8

ATOM
2400
N
ALA
A
499
102.901
67.401
67.874
1.00
30.40
7

ATOM
2401
CA
ALA
A
499
102.131
68.312
67.021
1.00
27.21
6

ATOM
2402
CB
ALA
A
499
100.644
67.935
67.066
1.00
24.53
6

ATOM
2403
C
ALA
A
499
102.300
69.806
67.341
1.00
23.91
6

ATOM
2404
O
ALA
A
499
102.237
70.641
66.439
1.00
24.36
8

ATOM
2405
N
ASP
A
500
102.505
70.152
68.607
1.00
21.80
7

ATOM
2406
CA
ASP
A
500
102.675
71.565
68.964
1.00
25.72
6

ATOM
2407
CB
ASP
A
500
102.819
71.732
70.478
1.00
28.09
6

ATOM
2408
CG
ASP
A
500
101.494
71.605
71.200
1.00
29.75
6

ATOM
2409
OD1
ASP
A
500
100.463
71.492
70.513
1.00
31.93
8

ATOM
2410
OD2
ASP
A
500
101.486
71.623
72.451
1.00
31.48
8

ATOM
2411
C
ASP
A
500
103.873
72.199
68.260
1.00
26.30
6

ATOM
2412
O
ASP
A
500
103.858
73.387
67.926
1.00
25.70
8

ATOM
2413
N
LYS
A
501
104.903
71.393
68.022
1.00
27.34
7

ATOM
2414
CA
LYS
A
501
106.110
71.853
67.344
1.00
27.60
6

ATOM
2415
CB
LYS
A
501
107.171
70.750
67.345
1.00
31.38
6

ATOM
2416
CG
LYS
A
501
108.503
71.153
67.946
1.00
36.52
6

ATOM
2417
CD
LYS
A
501
109.658
70.580
67.161
1.00
40.10
6

ATOM
2418
CE
LYS
A
501
110.980
71.069
67.718
1.00
41.87
6

ATOM
2419
NZ
LYS
A
501
111.131
72.542
67.568
1.00
45.28
7

ATOM
2420
C
LYS
A
501
105.833
72.318
65.882
1.00
27.00
6

ATOM
2421
O
LYS
A
501
106.642
73.063
65.314
1.00
26.50
8

ATOM
2422
N
LEU
A
502
104.695
71.897
65.274
1.00
25.82
7

ATOM
2423
CA
LEU
A
502
104.335
72.236
63.883
1.00
25.80
6

ATOM
2424
CB
LEU
A
502
103.551
71.099
63.204
1.00
29.47
6

ATOM
2425
CG
LEU
A
502
104.216
69.719
63.136
1.00
31.82
6

ATOM
2426
CD1
LEU
A
502
103.212
68.647
62.739
1.00
31.54
6

ATOM
2427
CD2
LEU
A
502
105.397
69.724
62.173
1.00
33.26
6

ATOM
2428
C
LEU
A
502
103.471
73.452
63.687
1.00
26.11
6

ATOM
2429
O
LEU
A
502
103.340
73.945
62.561
1.00
25.95
8

ATOM
2430
N
THR
A
503
102.876
73.934
64.748
1.00
24.15
7

ATOM
2431
CA
THR
A
503
102.002
75.073
64.568
1.00
23.50
6

ATOM
2432
CB
THR
A
503
101.454
75.486
65.916
1.00
23.24
6

ATOM
2433
OG1
THR
A
503
100.361
76.383
65.734
1.00
23.05
8

ATOM
2434
CG2
THR
A
503
102.555
76.137
66.741
1.00
19.81
6

ATOM
2435
C
THR
A
503
102.664
76.262
63.904
1.00
23.46
6

ATOM
2436
O
THR
A
503
103.838
76.571
64.140
1.00
22.97
8

ATOM
2437
N
SER
A
504
101.859
76.926
63.050
1.00
24.06
7

ATOM
2438
CA
SER
A
504
102.268
78.167
62.397
1.00
24.93
6

ATOM
2439
CB
SER
A
504
101.622
78.296
61.009
1.00
23.19
6

ATOM
2440
OG
SER
A
504
100.208
78.251
61.106
1.00
27.28
8

ATOM
2441
C
SER
A
504
101.833
79.357
63.270
1.00
24.61
6

ATOM
2442
O
SER
A
504
102.098
80.506
62.934
1.00
26.18
8

ATOM
2443
N
ALA
A
505
101.157
79.087
64.383
1.00
25.51
7

ATOM
2444
CA
ALA
A
505
100.729
80.180
65.256
1.00
25.51
6

ATOM
2445
CB
ALA
A
505
99.589
79.736
66.157
1.00
25.12
6

ATOM
2446
C
ALA
A
505
101.903
80.631
66.107
1.00
25.87
6

ATOM
2447
O
ALA
A
505
102.813
79.845
66.396
1.00
25.27
8

ATOM
2448
N
THR
A
506
101.886
81.897
66.511
1.00
24.03
7

ATOM
2449
CA
THR
A
506
102.958
82.422
67.353
1.00
24.84
6

ATOM
2450
CB
THR
A
506
103.450
83.798
66.856
1.00
23.83
6

ATOM
2451
OG1
THR
A
506
102.335
84.682
66.730
1.00
21.21
8

ATOM
2452
CG2
THR
A
506
104.152
83.657
65.510
1.00
23.58
6

ATOM
2453
C
THR
A
506
102.491
82.543
68.805
1.00
23.71
6

ATOM
2454
O
THR
A
506
101.293
82.500
69.089
1.00
25.70
8

ATOM
2455
N
ASN
A
507
103.447
82.707
69.718
1.00
23.90
7

ATOM
2456
CA
ASN
A
507
103.152
82.846
71.142
1.00
24.41
6

ATOM
2457
CB
ASN
A
507
104.463
82.771
71.931
1.00
23.91
6

ATOM
2458
CG
ASN
A
507
104.260
82.549
73.408
1.00
24.42
6

ATOM
2459
OD1
ASN
A
507
103.272
82.989
73.994
1.00
24.62
8

ATOM
2460
ND2
ASN
A
507
105.204
81.843
74.022
1.00
23.40
7

ATOM
2461
C
ASN
A
507
102.409
84.117
71.496
1.00
24.10
6

ATOM
2462
O
ASN
A
507
102.877
85.215
71.222
1.00
25.78
8

ATOM
2463
N
PRO
A
508
101.219
83.948
72.106
1.00
25.79
7

ATOM
2464
CD
PRO
A
508
100.345
82.862
71.606
1.00
25.89
6

ATOM
2465
CA
PRO
A
508
100.300
85.085
72.484
1.00
29.11
6

ATOM
2466
CB
PRO
A
508
99.101
84.368
73.049
1.00
26.98
6

ATOM
2467
CG
PRO
A
508
98.997
83.168
72.168
1.00
29.40
6

ATOM
2468
C
PRO
A
508
100.917
86.165
73.313
1.00
30.58
6

ATOM
2469
O
PRO
A
508
100.694
67.361
73.133
1.00
29.18
8

ATOM
2470
N
ASP
A
509
101.689
85.687
74.247
1.00
32.03
7

ATOM
2471
CA
ASP
A
509
102.380
86.494
75.208
1.00
34.03
6

ATOM
2472
CB
ASP
A
509
102.944
85.609
76.323
1.00
37.27
6

ATOM
2473
CG
ASP
A
509
103.456
86.406
77.509
1.00
41.74
6

ATOM
2474
OD1
ASP
A
509
103.765
87.597
77.335
1.00
41.44
8

ATOM
2475
OD2
ASP
A
509
103.533
85.827
78.618
1.00
44.22
8

ATOM
2476
C
ASP
A
509
103.508
87.298
74.567
1.00
33.79
6

ATOM
2477
O
ASP
A
509
104.646
86.846
74.510
1.00
35.02
8

ATOM
2478
N
LYS
A
510
103.229
88.490
74.078
1.00
34.74
7

ATOM
2479
CA
LYS
A
510
104.249
89.307
73.433
1.00
37.91
6

ATOM
2480
CB
LYS
A
510
103.569
90.275
72.434
1.00
39.34
6

ATOM
2481
CG
LYS
A
510
103.243
89.663
71.068
1.00
41.56
6

ATOM
2482
CD
LYS
A
510
102.048
88.706
71.136
1.00
43.30
6

ATOM
2483
CE
LYS
A
510
101.556
88.350
69.739
1.00
44.13
6

ATOM
2484
NZ
LYS
A
510
102.452
87.378
69.063
1.00
44.47
7

ATOM
2485
C
LYS
A
510
105.097
90.124
74.411
1.00
38.87
6

ATOM
2486
O
LYS
A
510
105.957
90.890
73.982
1.00
39.40
8

ATOM
2487
N
GLU
A
511
104.847
89.996
75.701
1.00
40.90
7

ATOM
2488
CA
GLU
A
511
105.522
90.794
76.718
1.00
41.77
6

ATOM
2489
CB
GLU
A
511
104.473
91.348
77.687
1.00
44.02
6

ATOM
2490
CG
GLU
A
511
103.239
91.887
76.985
1.00
49.38
6

ATOM
2491
CD
GLU
A
511
102.012
91.948
77.876
1.00
53.25
6

ATOM
2492
OE1
GLU
A
511
101.383
93.028
77.954
1.00
55.24
8

ATOM
2493
OE2
GLU
A
511
101.673
90.913
78.493
1.00
55.46
8

ATOM
2494
C
GLU
A
511
106.612
90.032
77.482
1.00
40.78
6

ATOM
2495
O
GLU
A
511
107.492
90.622
78.090
1.00
39.95
8

ATOM
2496
N
ASN
A
512
106.548
88.698
77.427
1.00
39.88
7

ATOM
2497
CA
ASN
A
512
107.503
87.869
78.151
1.00
39.87
6

ATOM
2498
CB
ASN
A
512
106.803
87.049
79.195
1.00
41.09
6

ATOM
2499
CG
ASN
A
512
106.067
87.919
80.149
1.00
40.94
6

ATOM
2500
OD1
ASN
A
512
106.684
88.675
80.904
1.00
43.47
8

ATOM
2501
ND2
ASN
A
512
104.743
87.817
80.140
1.00
41.72
7

ATOM
2502
C
ASN
A
512
108.232
86.865
77.295
1.00
39.20
6

ATOM
2503
O
ASN
A
512
109.200
86.239
77.737
1.00
39.14
8

ATOM
2504
N
SER
A
513
107.766
86.705
76.082
1.00
37.70
7

ATOM
2505
CA
SER
A
513
108.364
85.672
75.270
1.00
36.22
6

ATOM
2506
CB
SER
A
513
107.329
85.170
74.258
1.00
37.61
6

ATOM
2507
OG
SER
A
513
106.189
86.016
74.248
1.00
40.03
8

ATOM
2508
C
SER
A
513
109.600
86.076
74.522
1.00
34.54
6

ATOM
2509
O
SER
A
513
109.913
87.255
74.358
1.00
31.23
8

ATOM
2510
N
MET
A
514
110.310
85.054
74.066
1.00
31.81
7

ATOM
2511
CA
MET
A
514
111.483
85.262
73.236
1.00
30.54
6

ATOM
2512
CB
MET
A
514
112.305
83.966
73.147
1.00
31.80
6

ATOM
2513
CG
MET
A
514
113.384
83.954
72.065
1.00
32.96
6

ATOM
2514
SD
MET
A
514
114.680
85.192
72.299
1.00
35.28
16

ATOM
2515
CE
MET
A
514
115.720
84.347
73.523
1.00
34.70
6

ATOM
2516
C
MET
A
514
110.949
85.631
71.858
1.00
29.07
6

ATOM
2517
O
MET
A
514
109.900
85.138
71.443
1.00
27.75
8

ATOM
2518
N
SER
A
515
111.649
86.514
71.156
1.00
29.25
7

ATOM
2519
CA
SER
A
515
111.222
86.883
69.813
1.00
29.37
6

ATOM
2520
CB
SER
A
515
110.645
88.302
69.792
1.00
28.56
6

ATOM
2521
OG
SER
A
515
111.669
89.260
69.984
1.00
29.13
8

ATOM
2522
C
SER
A
515
112.416
86.798
68.870
1.00
28.19
6

ATOM
2523
O
SER
A
515
113.569
86.935
69.294
1.00
26.89
8

ATOM
2524
N
ILE
A
516
112.135
86.545
67.595
1.00
26.12
7

ATOM
2525
CA
ILE
A
516
113.186
86.467
66.585
1.00
24.23
6

ATOM
2526
CB
ILE
A
516
113.443
85.001
66.129
1.00
23.37
6

ATOM
2527
CG2
ILE
A
516
112.187
84.421
65.506
1.00
20.37
6

ATOM
2528
CG1
ILE
A
516
114.625
84.952
65.153
1.00
21.87
6

ATOM
2529
CD1
ILE
A
516
115.063
83.520
64.767
1.00
21.61
6

ATOM
2530
C
ILE
A
516
112.758
87.317
65.392
1.00
24.93
6

ATOM
2531
O
ILE
A
516
111.647
87.181
64.874
1.00
23.44
8

ATOM
2532
N
SER
A
517
113.650
88.206
64.970
1.00
24.79
7

ATOM
2533
CA
SER
A
517
113.378
89.098
63.861
1.00
25.17
6

ATOM
2534
CB
SER
A
517
113.835
90.517
64.224
1.00
25.01
6

ATOM
2535
OG
SER
A
517
113.227
90.927
65.438
1.00
29.91
8

ATOM
2536
C
SER
A
517
114.104
88.631
62.615
1.00
24.52
6

ATOM
2537
O
SER
A
517
115.309
88.360
62.652
1.00
26.27
8

ATOM
2538
N
ILE
A
518
113.376
88.545
61.511
1.00
23.76
7

ATOM
2539
CA
ILE
A
518
113.967
88.121
60.245
1.00
23.15
6

ATOM
2540
CB
ILE
A
518
113.581
86.651
59.895
1.00
21.98
6

ATOM
2541
CG2
ILE
A
518
114.065
85.685
61.004
1.00
23.34
6

ATOM
2542
CG1
ILE
A
518
112.068
86.557
59.671
1.00
21.53
6

ATOM
2543
CD1
ILE
A
518
111.581
85.190
59.129
1.00
23.43
6

ATOM
2544
C
ILE
A
518
113.453
89.006
59.106
1.00
26.69
6

ATOM
2545
O
ILE
A
518
112.462
89.726
59.266
1.00
23.93
8

ATOM
2546
N
LEU
A
519
114.135
88.930
57.964
1.00
26.46
7

ATOM
2547
CA
LEU
A
519
113.753
89.660
56.761
1.00
28.71
6

ATOM
2548
CB
LEU
A
519
114.785
90.736
56.396
1.00
29.16
6

ATOM
2549
CG
LEU
A
519
114.562
91.354
55.004
1.00
28.15
6

ATOM
2550
CD1
LEU
A
519
113.194
92.007
54.935
1.00
30.77
6

ATOM
2551
CD2
LEU
A
519
115.648
92.369
54.704
1.00
32.15
6

ATOM
2552
C
LEU
A
519
113.658
88.675
55.601
1.00
30.98
6

ATOM
2553
O
LEU
A
519
114.567
87.878
55.376
1.00
28.40
8

ATOM
2554
N
LEU
A
520
112.479
88.709
54.978
1.00
34.09
7

ATOM
2555
CA
LEU
A
520
112.186
87.841
53.869
1.00
39.00
6

ATOM
2556
CB
LEU
A
520
110.882
87.073
54.065
1.00
36.64
6

ATOM
2557
CG
LEU
A
520
111.124
85.608
54.379
1.00
38.86
6

ATOM
2558
CD1
LEU
A
520
112.223
85.440
55.426
1.00
38.04
6

ATOM
2559
CD2
LEU
A
520
109.837
84.953
54.868
1.00
35.20
6

ATOM
2560
C
LEU
A
520
112.193
88.732
52.669
1.00
43.86
6

ATOM
2561
O
LEU
A
520
111.458
89.715
52.521
1.00
44.46
8

ATOM
2562
N
ASP
A
521
113.087
88.311
51.813
1.00
49.55
7

ATOM
2563
CA
ASP
A
521
113.431
89.014
50.614
1.00
54.26
6

ATOM
2564
CB
ASP
A
521
114.476
88.255
49.833
1.00
57.21
6

ATOM
2565
CG
ASP
A
521
114.723
89.013
48.582
1.00
59.63
6

ATOM
2566
OD1
ASP
A
521
114.909
90.249
48.650
1.00
60.15
8

ATOM
2567
OD2
ASP
A
521
114.742
88.362
47.516
1.00
61.26
8

ATOM
2568
C
ASP
A
521
112.304
89.386
49.678
1.00
55.67
6

ATOM
2569
O
ASP
A
521
111.833
88.605
48.845
1.00
55.90
8

ATOM
2570
N
ASN
A
522
111.936
90.693
49.629
1.00
57.59
7

ATOM
2571
CA
ASN
A
522
110.811
91.358
48.821
1.00
59.08
6

ATOM
2572
CB
ASN
A
522
110.686
92.763
49.372
1.00
60.15
6

ATOM
2573
CG
ASN
A
522
109.322
92.927
49.935
1.00
60.28
6

ATOM
2574
OD1
ASN
A
522
108.399
92.209
49.528
1.00
60.62
8

ATOM
2575
ND2
ASN
A
522
109.160
93.850
50.877
1.00
61.71
7

ATOM
2576
C
ASN
A
522
110.766
91.464
47.230
1.00
59.95
6

ATOM
2577
O
ASN
A
522
111.621
90.912
46.522
1.00
60.83
8

ATOM
2578
N
TYR
A
523
109.719
92.186
46.757
1.00
20.00
7

ATOM
2579
CA
TYR
A
523
109.455
92.305
45.342
1.00
20.00
6

ATOM
2580
C
TYR
A
523
108.573
93.429
44.862
1.00
20.00
6

ATOM
2581
O
TYR
A
523
107.591
93.857
45.471
1.00
20.00
8

ATOM
2582
CB
TYR
A
523
108.907
90.999
44.845
1.00
20.00
6

ATOM
2583
CG
TYR
A
523
109.926
89.975
45.181
1.00
20.00
6

ATOM
2584
CD1
TYR
A
523
109.572
88.714
45.629
1.00
20.00
6

ATOM
2585
CD2
TYR
A
523
111.271
90.331
45.048
1.00
20.00
6

ATOM
2586
CE1
TYR
A
523
110.554
87.834
45.996
1.00
20.00
6

ATOM
2587
CE2
TYR
A
523
112.261
89.458
45.411
1.00
20.00
6

ATOM
2588
CZ
TYR
A
523
111.882
88.211
45.885
1.00
20.00
6

ATOM
2589
OH
TYR
A
523
112.865
87.307
46.248
1.00
20.00
8

ATOM
2590
N
CYS
A
524
108.686
93.646
43.523
1.00
20.00
7

ATOM
2591
CA
CYS
A
524
107.834
94.513
42.647
1.00
20.00
6

ATOM
2592
C
CYS
A
524
106.325
94.079
42.549
1.00
20.00
6

ATOM
2593
O
CYS
A
524
106.071
92.887
42.489
1.00
20.00
8

ATOM
2594
CB
CYS
A
524
108.394
94.465
41.239
1.00
20.00
6

ATOM
2595
SG
CYS
A
524
109.146
96.025
40.688
1.00
20.00
16

ATOM
2596
N
HIS
A
525
105.339
95.015
42.525
1.00
20.00
7

ATOM
2597
CA
HIS
A
525
103.890
94.619
42.360
1.00
20.00
6

ATOM
2598
C
HIS
A
525
102.875
95.667
41.947
1.00
20.00
6

ATOM
2599
O
HIS
A
525
102.911
96.791
42.439
1.00
20.00
8

ATOM
2600
CB
HIS
A
525
103.070
94.434
43.623
1.00
20.00
6

ATOM
2601
CG
HIS
A
525
103.537
93.702
44.833
1.00
20.00
6

ATOM
2602
ND1
HIS
A
525
103.057
92.455
45.084
1.00
20.00
7

ATOM
2603
CD2
HIS
A
525
104.359
94.034
45.860
1.00
20.00
6

ATOM
2604
CE1
HIS
A
525
103.550
92.008
46.229
1.00
20.00
6

ATOM
2605
NE2
HIS
A
525
104.341
92.944
46.712
1.00
20.00
7

ATOM
2606
N
PRO
A
526
101.983
95.299
41.049
1.00
20.00
7

ATOM
2607
CA
PRO
A
526
100.817
96.132
40.874
1.00
20.00
6

ATOM
2608
C
PRO
A
526
99.895
96.178
42.075
1.00
20.00
6

ATOM
2609
O
PRO
A
526
100.143
95.651
43.156
1.00
20.00
8

ATOM
2610
CB
PRO
A
526
100.164
95.598
39.633
1.00
20.00
6

ATOM
2611
CG
PRO
A
526
101.334
95.289
38.783
1.00
20.00
6

ATOM
2612
CD
PRO
A
526
102.523
95.122
39.679
1.00
20.00
6

ATOM
2613
N
ILE
A
527
98.793
96.870
41.784
1.00
20.00
7

ATOM
2614
CA
ILE
A
527
97.609
96.990
42.603
1.00
20.00
6

ATOM
2615
C
ILE
A
527
96.458
96.887
41.606
1.00
20.00
6

ATOM
2616
O
ILE
A
527
96.678
96.793
40.397
1.00
20.00
8

ATOM
2617
CB
ILE
A
527
97.460
98.333
43.378
1.00
20.00
6

ATOM
2618
CG1
ILE
A
527
98.553
98.476
44.438
1.00
20.00
6

ATOM
2619
CG2
ILE
A
527
96.079
98.445
44.015
1.00
20.00
6

ATOM
2620
CD1
ILE
A
527
98.590
99.835
45.100
1.00
20.00
6

ATOM
2621
N
TRP
A
617
91.176
53.634
43.913
1.00
45.70
7

ATOM
2622
CA
TRP
A
617
91.003
54.192
45.249
1.00
44.93
6

ATOM
2623
CB
TRP
A
617
91.940
55.386
45.444
1.00
43.14
6

ATOM
2624
CG
TRP
A
617
91.701
56.136
46.720
1.00
42.60
6

ATOM
2625
CD2
TRP
A
617
92.221
55.813
48.011
1.00
41.19
6

ATOM
2626
CE2
TRP
A
617
91.746
56.795
48.910
1.00
41.70
6

ATOM
2627
CE3
TRP
A
617
93.044
54.789
48.500
1.00
41.13
6

ATOM
2628
CD1
TRP
A
617
90.948
57.264
46.879
1.00
40.98
6

ATOM
2629
NE1
TRP
A
617
90.972
57.668
48.192
1.00
41.86
7

ATOM
2630
CZ2
TRP
A
617
92.070
56.785
50.273
1.00
41.18
6

ATOM
2631
CZ3
TRP
A
617
93.365
54.779
49.856
1.00
41.43
6

ATOM
2632
CH2
TRP
A
617
92.878
55.773
50.727
1.00
39.94
6

ATOM
2633
C
TRP
A
617
89.565
54.619
45.510
1.00
45.29
6

ATOM
2634
O
TRP
A
617
89.002
54.324
46.566
1.00
45.16
8

ATOM
2635
N
ASP
A
618
88.977
55.309
44.539
1.00
47.06
7

ATOM
2636
CA
ASP
A
618
87.606
55.781
44.657
1.00
49.28
6

ATOM
2637
CB
ASP
A
618
87.225
56.609
43.424
1.00
50.80
6

ATOM
2638
CG
ASP
A
618
88.207
57.739
43.145
1.00
53.47
6

ATOM
2639
OD1
ASP
A
618
88.568
58.470
44.089
1.00
53.71
8

ATOM
2640
OD2
ASP
A
618
88.612
57.907
41.975
1.00
54.75
8

ATOM
2641
C
ASP
A
618
86.606
54.635
44.823
1.00
49.55
6

ATOM
2642
O
ASP
A
618
85.541
54.817
45.414
1.00
49.38
8

ATOM
2643
N
SER
A
620
82.160
47.834
53.597
1.00
120.04
7

ATOM
2644
CA
SER
A
620
83.467
48.156
54.184
1.00
120.04
6

ATOM
2645
CB
SER
A
620
84.478
48.514
53.091
1.00
114.87
6

ATOM
2646
OG
SER
A
620
84.542
47.499
52.106
1.00
114.87
8

ATOM
2647
C
SER
A
620
83.268
49.275
55.216
1.00
120.04
6

ATOM
2648
O
SER
A
620
82.527
50.231
54.932
1.00
120.04
8

ATOM
2649
N
ALA
A
621
83.799
49.215
56.414
1.00
126.83
7

ATOM
2650
CA
ALA
A
621
83.421
50.284
57.320
1.00
126.83
6

ATOM
2651
CB
ALA
A
621
82.262
49.848
58.202
1.00
53.16
6

ATOM
2652
C
ALA
A
621
84.568
50.738
58.190
1.00
126.83
6

ATOM
2653
O
ALA
A
621
84.907
51.909
58.269
1.00
126.83
8

ATOM
2654
N
LEU
A
622
85.180
49.756
58.837
1.00
87.63
7

ATOM
2655
CA
LEU
A
622
86.364
50.000
59.626
1.00
85.57
6

ATOM
2656
CB
LEU
A
622
86.603
48.852
60.581
1.00
104.76
6

ATOM
2657
CG
LEU
A
622
85.448
48.518
61.511
1.00
105.42
6

ATOM
2658
CD1
LEU
A
622
85.788
47.329
62.386
1.00
104.68
6

ATOM
2659
CD2
LEU
A
622
85.080
49.734
62.347
1.00
107.13
6

ATOM
2660
C
LEU
A
622
87.556
50.264
58.687
1.00
84.15
6

ATOM
2661
O
LEU
A
622
88.403
51.100
58.993
1.00
82.55
8

ATOM
2662
N
ASP
A
623
87.626
49.553
57.545
1.00
63.77
7

ATOM
2663
CA
ASP
A
623
88.701
49.751
56.577
1.00
63.34
6

ATOM
2664
CB
ASP
A
623
88.361
49.112
55.239
1.00
133.05
6

ATOM
2665
CG
ASP
A
623
88.051
47.674
55.436
1.00
135.81
6

ATOM
2666
OD1
ASP
A
623
88.558
47.085
56.420
1.00
136.27
8

ATOM
2667
OD2
ASP
A
623
87.299
47.119
54.624
1.00
137.84
8

ATOM
2668
C
ASP
A
623
88.919
51.205
56.382
1.00
63.15
6

ATOM
2669
O
ASP
A
623
90.037
51.702
56.410
1.00
60.15
8

ATOM
2670
N
VAL
A
624
87.814
51.866
56.195
1.00
62.81
7

ATOM
2671
CA
VAL
A
624
87.841
53.278
56.030
1.00
60.77
6

ATOM
2672
CB
VAL
A
624
86.427
53.751
55.804
1.00
146.44
6

ATOM
2673
CG1
VAL
A
624
86.368
55.269
55.723
1.00
145.95
6

ATOM
2674
CG2
VAL
A
624
85.851
53.120
54.543
1.00
146.22
6

ATOM
2675
C
VAL
A
624
88.489
53.984
57.213
1.00
60.38
6

ATOM
2676
O
VAL
A
624
88.758
55.178
57.142
1.00
60.38
8

ATOM
2677
N
GLY
A
625
88.755
53.272
58.289
1.00
127.53
7

ATOM
2678
CA
GLY
A
625
89.402
53.958
59.396
1.00
127.53
6

ATOM
2679
C
GLY
A
625
90.868
54.234
59.044
1.00
127.53
6

ATOM
2680
O
GLY
A
625
91.509
55.141
59.566
1.00
127.53
8

ATOM
2681
N
LEU
A
626
91.366
53.394
58.148
1.00
56.23
7

ATOM
2682
CA
LEU
A
626
92.752
53.437
57.671
1.00
56.23
6

ATOM
2683
CB
LEU
A
626
93.111
52.137
56.940
1.00
197.30
6

ATOM
2684
CG
LEU
A
626
93.013
50.846
57.755
1.00
198.37
6

ATOM
2685
CD1
LEU
A
626
93.390
49.643
56.903
1.00
197.30
6

ATOM
2686
CD2
LEU
A
626
93.896
50.923
58.990
1.00
198.98
6

ATOM
2687
C
LEU
A
626
92.966
54.664
56.809
1.00
56.23
6

ATOM
2688
O
LEU
A
626
94.071
54.994
56.401
1.00
56.23
8

ATOM
2689
N
THR
A
627
91.878
55.333
56.609
1.00
53.16
7

ATOM
2690
CA
THR
A
627
91.834
56.585
55.904
1.00
53.16
6

ATOM
2691
CB
THR
A
627
90.379
56.924
55.569
1.00
152.09
6

ATOM
2692
OG1
THR
A
627
89.832
55.914
54.715
1.00
153.90
8

ATOM
2693
CG2
THR
A
627
90.310
58.287
54.895
1.00
152.95
6

ATOM
2694
C
THR
A
627
92.481
57.650
56.802
1.00
53.16
6

ATOM
2695
O
THR
A
627
92.631
58.792
56.408
1.00
53.16
8

ATOM
2696
N
MET
A
628
92.873
57.240
58.039
1.00
26.65
7

ATOM
2697
CA
MET
A
628
93.499
58.112
59.089
1.00
27.89
6

ATOM
2698
CB
MET
A
628
93.286
57.492
60.468
1.00
29.54
6

ATOM
2699
CG
MET
A
628
91.830
57.358
60.843
1.00
38.86
6

ATOM
2700
SD
MET
A
628
91.127
58.927
61.381
1.00
46.14
16

ATOM
2701
CE
MET
A
628
91.736
58.999
63.061
1.00
46.74
6

ATOM
2702
C
MET
A
628
95.004
58.330
58.874
1.00
25.76
6

ATOM
2703
O
MET
A
628
95.538
59.412
59.145
1.00
24.67
8

ATOM
2704
N
GLN
A
629
95.664
57.327
58.386
1.00
24.48
7

ATOM
2705
CA
GLN
A
629
97.083
57.507
58.141
1.00
25.53
6

ATOM
2706
CB
GLN
A
629
97.692
56.313
57.357
1.00
26.03
6

ATOM
2707
CG
GLN
A
629
97.510
54.916
57.925
1.00
30.99
6

ATOM
2708
CD
GLN
A
629
97.705
53.859
56.858
1.00
35.86
6

ATOM
2709
OE1
GLN
A
629
98.796
53.680
56.320
1.00
34.53
8

ATOM
2710
NE2
GLN
A
629
96.774
53.053
56.384
1.00
34.70
7

ATOM
2711
C
GLN
A
629
97.322
58.776
57.341
1.00
24.77
6

ATOM
2712
O
GLN
A
629
98.003
59.696
57.799
1.00
26.11
8

ATOM
2713
N
LEU
A
630
96.733
58.786
56.139
1.00
22.59
7

ATOM
2714
CA
LEU
A
630
96.879
59.899
55.225
1.00
23.66
6

ATOM
2715
CB
LEU
A
630
96.017
59.656
53.985
1.00
21.56
6

ATOM
2716
CG
LEU
A
630
96.326
58.355
53.263
1.00
25.59
6

ATOM
2717
CD1
LEU
A
630
95.374
58.140
52.109
1.00
23.07
6

ATOM
2718
CD2
LEU
A
630
97.768
58.353
52.791
1.00
24.62
6

ATOM
2719
C
LEU
A
630
96.601
61.248
55.843
1.00
24.21
6

ATOM
2720
O
LEU
A
630
96.854
62.264
55.199
1.00
23.22
8

ATOM
2721
N
LEU
A
631
96.076
61.290
57.060
1.00
22.93
7

ATOM
2722
CA
LEU
A
631
95.787
62.578
57.687
1.00
23.87
6

ATOM
2723
CB
LEU
A
631
94.309
62.643
58.115
1.00
18.83
6

ATOM
2724
CG
LEU
A
631
93.248
62.573
57.006
1.00
21.91
6

ATOM
2725
CD1
LEU
A
631
91.868
62.423
57.621
1.00
23.94
6

ATOM
2726
CD2
LEU
A
631
93.302
63.798
56.112
1.00
18.53
6

ATOM
2727
C
LEU
A
631
96.690
62.851
58.883
1.00
25.65
6

ATOM
2728
O
LEU
A
631
96.472
63.819
59.612
1.00
27.22
8

ATOM
2729
N
ASP
A
632
97.707
62.015
59.096
1.00
25.96
7

ATOM
2730
CA
ASP
A
632
98.595
62.251
60.226
1.00
28.42
6

ATOM
2731
CB
ASP
A
632
99.066
60.918
60.842
1.00
31.86
6

ATOM
2732
CG
ASP
A
632
100.191
60.254
60.063
1.00
37.69
6

ATOM
2733
OD1
ASP
A
632
100.418
60.605
58.887
1.00
39.16
8

ATOM
2734
OD2
ASP
A
632
100.844
59.356
60.640
1.00
37.54
8

ATOM
2735
C
ASP
A
632
99.776
63.150
59.848
1.00
29.40
6

ATOM
2736
O
ASP
A
632
99.800
63.723
58.753
1.00
27.08
8

ATOM
2737
N
CYS
A
633
100.745
63.272
60.753
1.00
27.95
7

ATOM
2738
CA
CYS
A
633
101.907
64.133
60.545
1.00
30.56
6

ATOM
2739
CB
CYS
A
633
102.750
64.188
61.827
1.00
32.03
6

ATOM
2740
SG
CYS
A
633
103.472
62.598
62.313
1.00
38.56
16

ATOM
2741
C
CYS
A
633
102.828
63.791
59.374
1.00
30.45
6

ATOM
2742
O
CYS
A
633
103.683
64.594
59.016
1.00
29.49
8

ATOM
2743
N
ASN
A
634
102.667
62.613
58.781
1.00
28.86
7

ATOM
2744
CA
ASN
A
634
103.566
62.195
57.679
1.00
29.86
6

ATOM
2745
CB
ASN
A
634
103.659
60.665
57.608
1.00
32.44
6

ATOM
2746
CG
ASN
A
634
103.618
60.047
58.979
1.00
34.47
6

ATOM
2747
OD1
ASN
A
634
102.563
59.596
59.421
1.00
37.22
8

ATOM
2748
ND2
ASN
A
634
104.767
60.013
59.665
1.00
38.81
7

ATOM
2749
C
ASN
A
634
103.164
62.708
56.308
1.00
28.53
6

ATOM
2750
O
ASN
A
634
103.992
62.851
55.410
1.00
29.23
8

ATOM
2751
N
PHE
A
635
101.883
62.966
56.163
1.00
29.34
7

ATOM
2752
CA
PHE
A
635
101.469
63.463
54.892
1.00
30.28
6

ATOM
2753
CB
PHE
A
635
100.291
62.766
54.335
1.00
31.95
6

ATOM
2754
CG
PHE
A
635
100.700
61.416
54.311
1.00
34.24
6

ATOM
2755
CD1
PHE
A
635
100.438
60.669
55.421
1.00
34.24
6

ATOM
2756
CD2
PHE
A
635
101.354
60.880
53.236
1.00
34.16
6

ATOM
2757
CE1
PHE
A
635
100.828
59.350
55.463
1.00
34.73
6

ATOM
2758
CE2
PHE
A
635
101.717
59.557
53.268
1.00
35.46
6

ATOM
2759
CZ
PHE
A
635
101.454
58.794
54.384
1.00
35.46
6

ATOM
2760
C
PHE
A
635
101.117
64.881
54.929
1.00
30.90
6

ATOM
2761
O
PHE
A
635
100.361
65.393
55.751
1.00
30.64
8

ATOM
2762
N
SER
A
636
101.738
65.546
53.998
1.00
29.14
7

ATOM
2763
CA
SER
A
636
101.376
66.874
53.712
1.00
30.07
6

ATOM
2764
CB
SER
A
636
102.526
67.850
53.578
1.00
26.76
6

ATOM
2765
OG
SER
A
636
103.633
67.261
52.928
1.00
30.07
8

ATOM
2766
C
SER
A
636
100.654
66.635
52.401
1.00
30.71
6

ATOM
2767
O
SER
A
636
99.757
65.788
52.334
1.00
33.36
8

ATOM
2768
N
ASP
A
637
101.016
67.323
51.353
1.00
30.06
7

ATOM
2769
CA
ASP
A
637
100.352
67.136
50.063
1.00
29.28
6

ATOM
2770
CB
ASP
A
637
100.856
65.941
49.312
1.00
27.34
6

ATOM
2771
CG
ASP
A
637
100.989
66.366
47.864
1.00
28.35
6

ATOM
2772
OD1
ASP
A
637
99.951
66.590
47.209
1.00
27.54
8

ATOM
2773
OD2
ASP
A
637
102.152
66.463
47.386
1.00
27.70
8

ATOM
2774
C
ASP
A
637
98.823
67.083
50.217
1.00
29.20
6

ATOM
2775
O
ASP
A
637
98.165
66.041
50.284
1.00
29.90
8

ATOM
2776
N
GLU
A
638
98.346
68.324
50.279
1.00
30.77
7

ATOM
2777
CA
GLU
A
638
96.980
68.739
50.385
1.00
33.60
6

ATOM
2778
CB
GLU
A
638
96.875
70.271
50.229
1.00
35.81
6

ATOM
2779
CG
GLU
A
638
97.778
71.034
51.184
1.00
43.69
6

ATOM
2780
CD
GLU
A
638
97.851
72.515
50.867
1.00
47.58
6

ATOM
2781
OE1
GLU
A
638
97.336
72.921
49.804
1.00
50.12
8

ATOM
2782
OE2
GLU
A
638
98.425
73.270
51.680
1.00
51.13
8

ATOM
2783
C
GLU
A
638
96.138
68.005
49.364
1.00
32.80
6

ATOM
2784
O
GLU
A
638
94.924
67.920
49.522
1.00
34.10
8

ATOM
2785
N
ASN
A
639
96.742
67.469
48.297
1.00
32.79
7

ATOM
2786
CA
ASN
A
639
95.998
66.652
47.336
1.00
31.08
6

ATOM
2787
CB
ASN
A
639
96.642
66.688
45.938
1.00
35.24
6

ATOM
2788
CG
ASN
A
639
97.508
67.916
45.738
1.00
39.09
6

ATOM
2789
OD1
ASN
A
639
97.019
69.045
45.771
1.00
42.32
8

ATOM
2790
ND2
ASN
A
639
98.804
67.706
45.549
1.00
43.18
7

ATOM
2791
C
ASN
A
639
95.945
65.243
47.879
1.00
29.13
6

ATOM
2792
O
ASN
A
639
94.958
64.532
47.715
1.00
28.74
8

ATOM
2793
N
VAL
A
640
97.025
64.816
48.537
1.00
28.91
7

ATOM
2794
CA
VAL
A
640
97.087
63.502
49.150
1.00
26.24
6

ATOM
2795
CB
VAL
A
640
98.510
63.229
49.700
1.00
28.62
6

ATOM
2796
CG1
VAL
A
640
98.523
61.999
50.598
1.00
25.93
6

ATOM
2797
CG2
VAL
A
640
99.481
63.046
48.548
1.00
26.18
6

ATOM
2798
C
VAL
A
640
96.091
63.390
50.276
1.00
27.41
6

ATOM
2799
O
VAL
A
640
95.337
62.424
50.387
1.00
27.12
8

ATOM
2800
N
ARG
A
641
96.121
64.406
51.109
1.00
25.14
7

ATOM
2801
CA
ARG
A
641
95.253
64.470
52.258
1.00
25.26
6

ATOM
2802
CB
ARG
A
641
95.719
65.606
53.179
1.00
24.56
6

ATOM
2803
CG
ARG
A
641
94.646
66.174
54.082
1.00
21.86
6

ATOM
2804
CD
ARG
A
641
95.221
66.949
55.247
1.00
22.05
6

ATOM
2805
NE
ARG
A
641
96.468
66.362
55.736
1.00
20.96
7

ATOM
2806
CZ
ARG
A
641
96.790
66.180
57.038
1.00
22.89
6

ATOM
2807
NH1
ARG
A
641
95.938
66.565
57.989
1.00
17.75
7

ATOM
2808
NH2
ARG
A
641
97.938
65.622
57.369
1.00
20.93
7

ATOM
2809
C
ARG
A
641
93.772
64.654
51.893
1.00
25.39
6

ATOM
2810
O
ARG
A
641
92.878
64.162
52.604
1.00
26.76
8

ATOM
2811
N
ALA
A
642
93.514
65.371
50.794
1.00
26.97
7

ATOM
2812
CA
ALA
A
642
92.172
65.689
50.332
1.00
28.07
6

ATOM
2813
CB
ALA
A
642
92.214
66.757
49.238
1.00
30.04
6

ATOM
2814
C
ALA
A
642
91.478
64.460
49.808
1.00
27.10
6

ATOM
2815
O
ALA
A
642
90.295
64.518
49.501
1.00
27.04
8

ATOM
2816
N
ILE
A
643
92.148
63.345
49.699
1.00
28.59
7

ATOM
2817
CA
ILE
A
643
91.420
62.245
49.169
1.00
28.32
6

ATOM
2818
CB
ILE
A
643
92.109
61.751
47.896
1.00
31.87
6

ATOM
2819
CG2
ILE
A
643
92.215
62.884
46.884
1.00
32.42
6

ATOM
2820
CG1
ILE
A
643
93.492
61.182
48.201
1.00
31.17
6

ATOM
2821
CD1
ILE
A
643
94.266
60.761
46.970
1.00
36.35
6

ATOM
2822
C
ILE
A
643
91.186
61.229
50.268
1.00
27.87
6

ATOM
2823
O
ILE
A
643
90.420
60.268
50.105
1.00
27.38
8

ATOM
2824
N
ALA
A
644
91.872
61.447
51.400
1.00
26.59
7

ATOM
2825
CA
ALA
A
644
91.603
60.682
52.586
1.00
25.99
6

ATOM
2826
CB
ALA
A
644
92.615
60.900
53.707
1.00
26.96
6

ATOM
2827
C
ALA
A
644
90.217
61.224
52.970
1.00
24.66
6

ATOM
2828
O
ALA
A
644
89.295
60.470
53.298
1.00
24.86
8

ATOM
2829
N
VAL
A
645
90.079
62.544
52.906
1.00
25.43
7

ATOM
2830
CA
VAL
A
645
88.819
63.212
53.211
1.00
27.33
6

ATOM
2831
CB
VAL
A
645
88.971
64.744
53.123
1.00
25.65
6

ATOM
2832
CG1
VAL
A
645
87.611
65.416
53.217
1.00
27.03
6

ATOM
2833
CG2
VAL
A
645
89.895
65.263
54.217
1.00
24.42
6

ATOM
2834
C
VAL
A
645
87.698
62.760
52.278
1.00
28.88
6

ATOM
2835
O
VAL
A
645
86.603
62.462
52.761
1.00
27.58
8

ATOM
2836
N
GLN
A
646
87.906
62.709
50.976
1.00
30.84
7

ATOM
2837
CA
GLN
A
646
86.794
62.283
50.097
1.00
32.04
6

ATOM
2838
CB
GLN
A
646
87.283
62.229
48.641
1.00
35.35
6

ATOM
2839
CG
GLN
A
646
86.403
61.425
47.699
1.00
41.08
6

ATOM
2840
CD
GLN
A
646
87.072
61.170
46.371
1.00
44.00
6

ATOM
2841
OE1
GLN
A
646
86.731
60.209
45.691
1.00
45.31
8

ATOM
2842
NE2
GLN
A
646
88.034
61.893
45.802
1.00
44.33
7

ATOM
2843
C
GLN
A
646
86.214
60.922
50.509
1.00
32.19
6

ATOM
2844
O
GLN
A
646
85.045
60.597
50.297
1.00
33.01
8

ATOM
2845
N
LYS
A
647
87.110
60.149
51.130
1.00
30.13
7

ATOM
2846
CA
LYS
A
647
86.897
58.814
51.658
1.00
31.36
6

ATOM
2847
CB
LYS
A
647
88.206
58.299
52.286
1.00
32.66
6

ATOM
2848
CG
LYS
A
647
88.713
56.998
51.749
1.00
39.31
6

ATOM
2849
CD
LYS
A
647
89.077
57.152
50.288
1.00
41.07
6

ATOM
2850
CE
LYS
A
647
88.805
55.868
49.504
1.00
43.21
6

ATOM
2851
NZ
LYS
A
647
89.529
54.698
50.081
1.00
44.13
7

ATOM
2852
C
LYS
A
647
85.891
58.796
52.747
1.00
31.09
6

ATOM
2853
O
LYS
A
647
84.910
58.059
52.783
1.00
32.34
8

ATOM
2854
N
LEU
A
648
86.253
59.668
53.643
1.00
28.97
7

ATOM
2855
CA
LEU
A
648
85.526
59.898
54.839
1.00
27.95
6

ATOM
2856
CB
LEU
A
648
86.345
60.842
55.724
1.00
25.96
6

ATOM
2857
CG
LEU
A
648
87.722
60.272
56.086
1.00
26.50
6

ATOM
2858
CD1
LEU
A
648
88.592
61.339
56.730
1.00
26.87
6

ATOM
2859
CD2
LEU
A
648
87.578
59.075
57.017
1.00
27.55
6

ATOM
2860
C
LEU
A
648
84.094
60.379
54.553
1.00
27.19
6

ATOM
2861
O
LEU
A
648
83.193
60.147
55.368
1.00
28.32
8

ATOM
2862
N
GLU
A
649
83.882
61.059
53.422
1.00
28.97
7

ATOM
2863
CA
GLU
A
649
82.539
61.568
53.006
1.00
31.88
6

ATOM
2864
CB
GLU
A
649
82.628
62.192
51.605
1.00
33.27
6

ATOM
2865
CG
GLU
A
649
83.505
63.451
51.527
1.00
36.44
6

ATOM
2866
CD
GLU
A
649
82.815
64.701
52.051
1.00
37.45
6

ATOM
2867
OE1
GLU
A
649
81.690
64.585
52.582
1.00
38.09
8

ATOM
2868
OE2
GLU
A
649
83.395
65.812
51.933
1.00
39.56
8

ATOM
2869
C
GLU
A
649
81.457
60.484
53.030
1.00
32.19
6

ATOM
2870
O
GLU
A
649
80.276
60.789
53.176
1.00
32.73
8

ATOM
2871
N
SER
A
650
81.852
59.222
52.873
1.00
31.70
7

ATOM
2872
CA
SER
A
650
80.881
58.136
52.862
1.00
33.40
6

ATOM
2873
CB
SER
A
650
81.363
57.006
51.948
1.00
34.84
6

ATOM
2874
OG
SER
A
650
82.337
56.217
52.605
1.00
35.88
8

ATOM
2875
C
SER
A
650
80.543
57.551
54.236
1.00
33.28
6

ATOM
2876
O
SER
A
650
79.770
56.605
54.328
1.00
33.85
8

ATOM
2877
N
LEU
A
651
81.124
58.095
55.302
1.00
32.18
7

ATOM
2878
CA
LEU
A
651
80.828
57.590
56.639
1.00
31.39
6

ATOM
2879
CB
LEU
A
651
81.821
58.149
57.662
1.00
32.40
6

ATOM
2880
CG
LEU
A
651
83.256
57.629
57.682
1.00
34.49
6

ATOM
2881
CD1
LEU
A
651
84.109
58.559
58.527
1.00
33.00
6

ATOM
2882
CD2
LEU
A
651
83.286
56.221
58.230
1.00
32.88
6

ATOM
2883
C
LEU
A
651
79.427
58.028
57.033
1.00
30.88
6

ATOM
2884
O
LEU
A
651
79.014
59.149
56.721
1.00
29.87
8

ATOM
2885
N
GLU
A
652
78.677
57.152
57.693
1.00
30.09
7

ATOM
2886
CA
GLU
A
652
77.348
57.558
58.123
1.00
31.63
6

ATOM
2887
CB
GLU
A
652
76.410
56.354
58.263
1.00
34.09
6

ATOM
2888
CG
GLU
A
652
76.765
55.333
59.337
1.00
36.31
6

ATOM
2889
CD
GLU
A
652
75.753
54.188
59.376
1.00
39.22
6

ATOM
2890
OE1
GLU
A
652
75.802
53.358
60.308
1.00
36.29
8

ATOM
2891
OE2
GLU
A
652
74.905
54.122
58.455
1.00
42.27
8

ATOM
2892
C
GLU
A
652
77.551
58.268
59.459
1.00
31.80
6

ATOM
2893
O
GLU
A
652
78.568
58.066
60.115
1.00
31.04
8

ATOM
2894
N
ASP
A
653
76.601
59.112
59.850
1.00
32.26
7

ATOM
2895
CA
ASP
A
653
76.730
59.864
61.094
1.00
31.46
6

ATOM
2896
CB
ASP
A
653
75.410
60.529
61.458
1.00
29.85
6

ATOM
2897
CG
ASP
A
653
75.035
61.636
60.512
1.00
30.95
6

ATOM
2898
OD1
ASP
A
653
75.931
62.244
59.883
1.00
30.50
8

ATOM
2899
OD2
ASP
A
653
73.825
61.919
60.422
1.00
32.47
8

ATOM
2900
C
ASP
A
653
77.213
59.056
62.290
1.00
30.77
6

ATOM
2901
O
ASP
A
653
78.063
59.522
63.060
1.00
29.88
8

ATOM
2902
N
ASP
A
654
76.681
57.851
62.462
1.00
30.30
7

ATOM
2903
CA
ASP
A
654
77.099
57.041
63.600
1.00
31.22
6

ATOM
2904
CB
ASP
A
654
76.340
55.716
63.667
1.00
33.98
6

ATOM
2905
CG
ASP
A
654
76.957
54.746
64.676
1.00
38.76
6

ATOM
2906
OD1
ASP
A
654
76.974
55.072
65.886
1.00
38.21
8

ATOM
2907
OD2
ASP
A
654
77.427
53.663
64.261
1.00
39.42
8

ATOM
2908
C
ASP
A
654
78.587
56.752
63.579
1.00
29.90
6

ATOM
2909
O
ASP
A
654
79.215
56.669
64.636
1.00
30.74
8

ATOM
2910
N
ASP
A
655
79.159
56.589
62.391
1.00
26.96
7

ATOM
2911
CA
ASP
A
655
80.589
56.312
62.312
1.00
27.98
6

ATOM
2912
CB
ASP
A
655
80.916
55.608
61.000
1.00
27.70
6

ATOM
2913
CG
ASP
A
655
80.631
54.119
61.046
1.00
34.13
6

ATOM
2914
OD1
ASP
A
655
80.964
53.487
62.079
1.00
35.58
8

ATOM
2915
OD2
ASP
A
655
80.090
53.580
60.058
1.00
37.41
8

ATOM
2916
C
ASP
A
655
81.427
57.569
62.500
1.00
23.22
6

ATOM
2917
O
ASP
A
655
82.499
57.512
63.091
1.00
24.27
8

ATOM
2918
N
VAL
A
656
80.933
58.696
62.009
1.00
22.37
7

ATOM
2919
CA
VAL
A
656
81.643
59.952
62.205
1.00
22.52
6

ATOM
2920
CB
VAL
A
656
80.913
61.134
61.470
1.00
23.31
6

ATOM
2921
CG1
VAL
A
656
81.421
62.474
61.993
1.00
21.57
6

ATOM
2922
CG2
VAL
A
656
81.110
61.034
59.953
1.00
22.09
6

ATOM
2923
C
VAL
A
656
81.813
60.243
63.734
1.00
23.54
6

ATOM
2924
O
VAL
A
656
82.875
60.710
64.149
1.00
24.13
8

ATOM
2925
N
LEU
A
657
80.795
59.995
64.540
1.00
25.78
7

ATOM
2926
CA
LEU
A
657
80.894
60.249
65.982
1.00
25.09
6

ATOM
2927
CB
LEU
A
657
79.530
60.096
66.637
1.00
25.44
6

ATOM
2928
CG
LEU
A
657
78.673
61.352
66.789
1.00
25.86
6

ATOM
2929
CD1
LEU
A
657
77.308
61.010
67.361
1.00
24.25
6

ATOM
2930
CD2
LEU
A
657
79.381
62.385
67.658
1.00
24.53
6

ATOM
2931
C
LEU
A
657
81.841
59.321
66.673
1.00
26.32
6

ATOM
2932
O
LEU
A
657
82.149
59.497
67.865
1.00
25.53
8

ATOM
2933
N
HIS
A
658
82.319
58.326
65.972
1.00
26.32
7

ATOM
2934
CA
HIS
A
658
83.261
57.403
66.565
1.00
25.83
6

ATOM
2935
CB
HIS
A
658
83.123
56.030
65.956
1.00
30.78
6

ATOM
2936
CG
HIS
A
658
81.789
55.446
66.341
1.00
36.07
6

ATOM
2937
CD2
HIS
A
658
81.427
54.696
67.407
1.00
36.62
6

ATOM
2938
ND1
HIS
A
658
80.652
55.603
65.578
1.00
41.49
7

ATOM
2939
CE1
HIS
A
658
79.645
54.976
66.162
1.00
40.53
6

ATOM
2940
NE2
HIS
A
658
80.089
54.419
67.274
1.00
40.67
7

ATOM
2941
C
HIS
A
658
84.640
57.842
66.346
1.00
24.83
6

ATOM
2942
O
HIS
A
658
85.551
57.510
67.095
1.00
24.83
8

ATOM
2943
N
TYR
A
659
84.801
58.583
65.322
1.00
22.48
7

ATOM
2944
CA
TYR
A
659
86.099
59.040
65.029
1.00
22.72
6

ATOM
2945
CB
TYR
A
659
86.502
58.562
63.642
1.00
22.56
6

ATOM
2946
CG
TYR
A
659
86.517
57.070
63.520
1.00
27.07
6

ATOM
2947
CD1
TYR
A
659
85.519
56.356
62.861
1.00
26.24
6

ATOM
2948
CE1
TYR
A
659
85.558
54.960
62.774
1.00
31.15
6

ATOM
2949
CD2
TYR
A
659
87.554
56.357
64.080
1.00
27.01
6

ATOM
2950
CE2
TYR
A
659
87.599
54.974
64.031
1.00
30.22
6

ATOM
2951
CZ
TYR
A
659
86.606
54.282
63.384
1.00
31.42
6

ATOM
2952
OH
TYR
A
659
86.636
52.907
63.332
1.00
37.03
8

ATOM
2953
C
TYR
A
659
86.198
60.546
65.122
1.00
21.59
6

ATOM
2954
O
TYR
A
659
87.224
61.125
64.759
1.00
22.01
8

ATOM
2955
N
LEU
A
660
85.167
61.196
65.614
1.00
20.37
7

ATOM
2956
CA
LEU
A
660
85.309
62.641
65.672
1.00
20.61
6

ATOM
2957
CB
LEU
A
660
84.136
63.317
66.359
1.00
19.19
6

ATOM
2958
CG
LEU
A
660
84.078
64.840
66.118
1.00
21.13
6

ATOM
2959
CD1
LEU
A
660
84.151
65.145
64.629
1.00
19.95
6

ATOM
2960
CD2
LEU
A
660
82.824
65.440
66.727
1.00
19.56
6

ATOM
2961
C
LEU
A
660
86.625
63.043
66.347
1.00
19.85
6

ATOM
2962
O
LEU
A
660
87.541
63.487
65.650
1.00
22.45
8

ATOM
2963
N
LEU
A
661
86.747
62.910
67.699
1.00
19.28
7

ATOM
2964
CA
LEU
A
661
87.956
63.350
68.458
1.00
19.95
6

ATOM
2965
CB
LEU
A
661
88.142
62.552
69.772
1.00
19.00
6

ATOM
2966
CG
LEU
A
661
89.145
63.107
70.805
1.00
20.12
6

ATOM
2967
CD1
LEU
A
661
88.904
64.589
71.060
1.00
16.41
6

ATOM
2968
CD2
LEU
A
661
89.066
62.321
72.109
1.00
18.83
6

ATOM
2969
C
LEU
A
661
89.295
63.308
67.657
1.00
20.90
6

ATOM
2970
O
LEU
A
661
89.953
64.344
67.562
1.00
19.64
8

ATOM
2971
N
GLN
A
662
89.728
62.188
67.079
1.00
20.78
7

ATOM
2972
CA
GLN
A
662
90.994
62.233
66.315
1.00
20.85
6

ATOM
2973
CB
GLN
A
662
91.432
60.839
65.828
1.00
24.65
6

ATOM
2974
CG
GLN
A
662
91.848
59.853
66.901
1.00
32.64
6

ATOM
2975
CD
GLN
A
662
90.698
58.958
67.237
1.00
33.81
6

ATOM
2976
OE1
GLN
A
662
89.647
59.428
67.682
1.00
36.40
8

ATOM
2977
NE2
GLN
A
662
90.659
57.646
67.100
1.00
37.45
7

ATOM
2978
C
GLN
A
662
90.801
63.124
65.092
1.00
21.61
6

ATOM
2979
O
GLN
A
662
91.646
63.957
64.784
1.00
21.18
8

ATOM
2980
N
LEU
A
663
89.676
62.932
64.380
1.00
20.11
7

ATOM
2981
CA
LEU
A
663
89.412
63.761
63.213
1.00
19.06
6

ATOM
2982
CB
LEU
A
663
88.016
63.506
62.675
1.00
18.31
6

ATOM
2983
CG
LEU
A
663
87.840
62.211
61.880
1.00
21.54
6

ATOM
2984
CD1
LEU
A
663
86.477
62.189
61.209
1.00
18.85
6

ATOM
2985
CD2
LEU
A
663
88.947
62.053
60.864
1.00
24.05
6

ATOM
2986
C
LEU
A
663
89.668
65.234
63.603
1.00
20.38
6

ATOM
2987
O
LEU
A
663
90.396
65.950
62.915
1.00
20.16
8

ATOM
2988
N
VAL
A
664
89.083
65.679
64.710
1.00
18.99
7

ATOM
2989
CA
VAL
A
664
89.319
67.043
65.180
1.00
18.29
6

ATOM
2990
CB
VAL
A
664
88.461
67.367
66.427
1.00
19.25
6

ATOM
2991
CG1
VAL
A
664
88.778
68.763
66.959
1.00
20.97
6

ATOM
2992
CG2
VAL
A
664
86.966
67.256
66.114
1.00
20.75
6

ATOM
2993
C
VAL
A
664
90.797
67.203
65.537
1.00
19.43
6

ATOM
2994
O
VAL
A
664
91.427
68.198
65.183
1.00
19.07
8

ATOM
2995
N
GLN
A
665
91.369
66.225
66.236
1.00
19.27
7

ATOM
2996
CA
GLN
A
665
92.789
66.330
66.579
1.00
19.89
6

ATOM
2997
CB
GLN
A
665
93.221
65.154
67.467
1.00
21.40
6

ATOM
2998
CG
GLN
A
665
93.043
65.386
68.976
1.00
22.65
6

ATOM
2999
CD
GLN
A
665
93.872
66.563
69.489
1.00
28.77
6

ATOM
3000
OE1
GLN
A
665
95.065
66.663
69.203
1.00
32.49
8

ATOM
3001
NE2
GLN
A
665
93.428
67.550
70.248
1.00
29.04
7

ATOM
3002
C
GLN
A
665
93.676
66.373
65.329
1.00
19.94
6

ATOM
3003
O
GLN
A
665
94.696
67.072
65.295
1.00
16.63
8

ATOM
3004
N
ALA
A
666
93.276
65.630
64.300
1.00
20.46
7

ATOM
3005
CA
ALA
A
666
94.048
65.557
63.064
1.00
20.53
6

ATOM
3006
CB
ALA
A
666
93.480
64.484
62.164
1.00
16.77
6

ATOM
3007
C
ALA
A
666
94.104
66.905
62.327
1.00
19.79
6

ATOM
3008
O
ALA
A
666
94.919
67.064
61.419
1.00
19.71
8

ATOM
3009
N
VAL
A
667
93.253
67.848
62.686
1.00
19.58
7

ATOM
3010
CA
VAL
A
667
93.299
69.163
62.055
1.00
19.41
6

ATOM
3011
CB
VAL
A
667
92.147
70.074
62.587
1.00
21.46
6

ATOM
3012
CG1
VAL
A
667
92.389
71.511
62.171
1.00
22.17
6

ATOM
3013
CG2
VAL
A
667
90.787
69.593
62.093
1.00
22.12
6

ATOM
3014
C
VAL
A
667
94.660
69.775
62.324
1.00
20.78
6

ATOM
3015
O
VAL
A
667
95.136
70.625
61.572
1.00
20.17
8

ATOM
3016
N
LYS
A
668
95.286
69.338
63.376
1.00
20.03
7

ATOM
3017
CA
LYS
A
668
96.610
69.855
63.700
1.00
19.79
6

ATOM
3018
CB
LYS
A
668
97.110
69.301
65.041
1.00
20.06
6

ATOM
3019
CG
LYS
A
668
96.283
69.761
66.223
1.00
23.77
6

ATOM
3020
CD
LYS
A
668
96.841
69.188
67.521
1.00
21.56
6

ATOM
3021
CE
LYS
A
668
96.071
69.689
68.729
1.00
23.99
6

ATOM
3022
NZ
LYS
A
668
96.599
69.125
69.999
1.00
24.85
7

ATOM
3023
C
LYS
A
668
97.605
69.549
62.624
1.00
19.92
6

ATOM
3024
O
LYS
A
668
98.441
70.386
62.256
1.00
18.46
8

ATOM
3025
N
PHE
A
669
97.496
68.356
62.131
1.00
17.67
7

ATOM
3026
CA
PHE
A
669
98.432
67.987
61.118
1.00
19.12
6

ATOM
3027
CB
PHE
A
669
98.368
66.468
60.932
1.00
21.70
6

ATOM
3028
CG
PHE
A
669
98.971
65.704
62.072
1.00
18.18
6

ATOM
3029
CD1
PHE
A
669
98.215
64.743
62.718
1.00
20.74
6

ATOM
3030
CD2
PHE
A
669
100.279
65.920
62.493
1.00
21.98
6

ATOM
3031
CE1
PHE
A
669
98.745
64.006
63.778
1.00
23.55
6

ATOM
3032
CE2
PHE
A
669
100.817
65.191
63.548
1.00
22.52
6

ATOM
3033
CZ
PHE
A
669
100.047
64.232
64.190
1.00
21.70
6

ATOM
3034
C
PHE
A
669
98.250
68.786
59.829
1.00
22.99
6

ATOM
3035
O
PHE
A
669
99.057
68.618
58.922
1.00
23.48
8

ATOM
3036
N
GLU
A
670
97.221
69.651
59.717
1.00
21.13
7

ATOM
3037
CA
GLU
A
670
96.994
70.481
58.523
1.00
22.57
6

ATOM
3038
CB
GLU
A
670
95.522
70.913
58.471
1.00
23.59
6

ATOM
3039
CG
GLU
A
670
94.604
70.102
57.583
1.00
27.36
6

ATOM
3040
CD
GLU
A
670
95.359
69.091
56.732
1.00
29.50
6

ATOM
3041
OE1
GLU
A
670
95.582
69.366
55.535
1.00
30.49
8

ATOM
3042
OE2
GLU
A
670
95.734
68.023
57.268
1.00
30.23
8

ATOM
3043
C
GLU
A
670
97.841
71.760
58.529
1.00
23.57
6

ATOM
3044
O
GLU
A
670
97.997
72.378
59.592
1.00
19.88
8

ATOM
3045
N
PRO
A
671
98.428
72.197
57.352
1.00
24.42
7

ATOM
3046
CD
PRO
A
671
99.296
71.297
56.597
1.00
26.18
6

ATOM
3047
CA
PRO
A
671
99.182
73.472
57.378
1.00
23.70
6

ATOM
3048
CB
PRO
A
671
99.750
73.615
55.991
1.00
25.04
6

ATOM
3049
CG
PRO
A
671
100.113
72.200
55.697
1.00
27.66
6

ATOM
3050
C
PRO
A
671
98.304
74.597
57.761
1.00
23.60
6

ATOM
3051
O
PRO
A
671
98.259
75.162
58.853
1.00
21.85
8

ATOM
3052
N
TYR
A
672
97.627
74.819
56.684
1.00
24.29
7

ATOM
3053
CA
TYR
A
672
96.646
75.770
56.457
1.00
24.50
6

ATOM
3054
CB
TYR
A
672
96.343
75.766
54.963
1.00
22.54
6

ATOM
3055
CG
TYR
A
672
97.599
76.135
54.159
1.00
23.87
6

ATOM
3056
CD1
TYR
A
672
98.350
75.195
53.443
1.00
20.60
6

ATOM
3057
CE1
TYR
A
672
99.517
75.581
52.748
1.00
22.81
6

ATOM
3058
CD2
TYR
A
672
98.030
77.461
54.160
1.00
19.62
6

ATOM
3059
CE2
TYR
A
672
99.184
77.850
53.476
1.00
23.42
6

ATOM
3060
CZ
TYR
A
672
99.924
76.907
52.778
1.00
21.55
6

ATOM
3061
OH
TYR
A
672
101.056
77.292
52.116
1.00
24.17
8

ATOM
3062
C
TYR
A
672
95.486
75.470
57.322
1.00
24.40
6

ATOM
3063
O
TYR
A
672
95.115
74.324
57.590
1.00
24.35
8

ATOM
3064
N
HIS
A
673
94.920
76.579
57.728
1.00
24.90
7

ATOM
3065
CA
HIS
A
673
93.787
76.632
58.582
1.00
24.47
6

ATOM
3066
CB
HIS
A
673
93.562
78.067
59.039
1.00
24.94
6

ATOM
3067
CG
HIS
A
673
94.734
78.625
59.859
1.00
22.77
6

ATOM
3068
CD2
HIS
A
673
95.416
79.787
59.741
1.00
25.61
6

ATOM
3069
ND1
HIS
A
673
95.296
77.961
60.929
1.00
27.26
7

ATOM
3070
CE1
HIS
A
673
96.275
78.689
61.435
1.00
24.31
6

ATOM
3071
NE2
HIS
A
673
96.369
79.803
60.733
1.00
25.27
7

ATOM
3072
C
HIS
A
673
92.569
76.157
57.858
1.00
26.37
6

ATOM
3073
O
HIS
A
673
91.763
75.412
58.423
1.00
26.41
8

ATOM
3074
N
ASP
A
674
92.429
76.574
56.609
1.00
27.20
7

ATOM
3075
CA
ASP
A
674
91.287
76.162
55.825
1.00
28.01
6

ATOM
3076
CB
ASP
A
674
90.886
77.275
54.856
1.00
28.51
6

ATOM
3077
CG
ASP
A
674
89.651
76.930
54.063
1.00
29.86
6

ATOM
3078
OD1
ASP
A
674
89.246
75.750
54.065
1.00
31.34
8

ATOM
3079
OD2
ASP
A
674
89.084
77.839
53.430
1.00
34.32
8

ATOM
3080
C
ASP
A
674
91.717
74.911
55.062
1.00
28.62
6

ATOM
3081
O
ASP
A
674
92.607
74.964
54.212
1.00
31.42
8

ATOM
3082
N
SER
A
675
91.100
73.783
55.380
1.00
27.13
7

ATOM
3083
CA
SER
A
675
91.444
72.534
54.718
1.00
25.20
6

ATOM
3084
CB
SER
A
675
92.378
71.703
55.603
1.00
23.67
6

ATOM
3085
OG
SER
A
675
92.408
72.215
56.927
1.00
21.86
8

ATOM
3086
C
SER
A
675
90.195
71.734
54.441
1.00
25.11
6

ATOM
3087
O
SER
A
675
89.117
72.040
54.958
1.00
25.84
8

ATOM
3088
N
ALA
A
676
90.347
70.706
53.617
1.00
24.48
7

ATOM
3089
CA
ALA
A
676
89.236
69.840
53.270
1.00
21.55
6

ATOM
3090
CB
ALA
A
676
89.689
68.796
52.236
1.00
21.95
6

ATOM
3091
C
ALA
A
676
88.748
69.149
54.548
1.00
20.66
6

ATOM
3092
O
ALA
A
676
87.551
68.962
54.738
1.00
21.51
8

ATOM
3093
N
LEU
A
677
89.671
68.759
55.423
1.00
21.16
7

ATOM
3094
CA
LEU
A
677
89.272
68.094
56.671
1.00
19.62
6

ATOM
3095
CB
LEU
A
677
90.502
67.635
57.474
1.00
20.42
6

ATOM
3096
CG
LEU
A
677
90.209
67.044
58.872
1.00
20.11
6

ATOM
3097
CD1
LEU
A
677
89.240
65.856
58.760
1.00
18.78
6

ATOM
3098
CD2
LEU
A
677
91.522
66.612
59.538
1.00
20.29
6

ATOM
3099
C
LEU
A
677
88.429
69.048
57.525
1.00
17.57
6

ATOM
3100
O
LEU
A
677
87.387
68.665
58.054
1.00
18.12
8

ATOM
3101
N
ALA
A
678
88.875
70.293
57.645
1.00
18.34
7

ATOM
3102
CA
ALA
A
678
88.142
71.272
58.448
1.00
17.93
6

ATOM
3103
CB
ALA
A
678
88.919
72.597
58.492
1.00
17.83
6

ATOM
3104
C
ALA
A
678
86.757
71.484
57.864
1.00
20.58
6

ATOM
3105
O
ALA
A
678
85.752
71.595
58.595
1.00
17.39
8

ATOM
3106
N
ARG
A
679
86.691
71.522
56.534
1.00
21.36
7

ATOM
3107
CA
ARG
A
679
85.409
71.731
55.870
1.00
23.88
6

ATOM
3108
CB
ARG
A
679
85.614
71.984
54.377
1.00
23.79
6

ATOM
3109
CG
ARG
A
679
86.250
73.337
54.120
1.00
27.65
6

ATOM
3110
CD
ARG
A
679
86.092
73.784
52.669
1.00
26.88
6

ATOM
3111
NE
ARG
A
679
86.528
75.169
52.523
1.00
29.31
7

ATOM
3112
CZ
ARG
A
679
86.198
75.955
51.503
1.00
30.12
6

ATOM
3113
NH1
ARG
A
679
85.424
75.491
50.528
1.00
33.23
7

ATOM
3114
NH2
ARG
A
679
86.624
77.211
51.471
1.00
28.97
7

ATOM
3115
C
ARG
A
679
84.529
70.530
56.084
1.00
23.78
6

ATOM
3116
O
ARG
A
679
83.327
70.659
56.294
1.00
22.63
8

ATOM
3117
N
PHE
A
680
85.135
69.354
56.050
1.00
22.59
7

ATOM
3118
CA
PHE
A
680
84.388
68.125
56.280
1.00
23.68
6

ATOM
3119
CB
PHE
A
680
85.306
66.916
56.136
1.00
20.56
6

ATOM
3120
CG
PHE
A
680
84.785
65.686
56.809
1.00
22.84
6

ATOM
3121
CD1
PHE
A
680
83.718
64.972
56.260
1.00
22.03
6

ATOM
3122
CD2
PHE
A
680
85.359
65.237
57.997
1.00
22.79
6

ATOM
3123
CE1
PHE
A
680
83.232
63.820
56.886
1.00
22.38
6

ATOM
3124
CE2
PHE
A
680
84.881
64.089
58.631
1.00
21.92
6

ATOM
3125
CZ
PHE
A
680
83.812
63.377
58.070
1.00
23.29
6

ATOM
3126
C
PHE
A
680
83.775
68.118
57.692
1.00
23.45
6

ATOM
3127
O
PHE
A
680
82.633
67.694
57.879
1.00
24.83
8

ATOM
3128
N
LEU
A
681
84.540
68.555
58.686
1.00
23.38
7

ATOM
3129
CA
LEU
A
681
84.032
68.593
60.064
1.00
24.14
6

ATOM
3130
CB
LEU
A
681
85.166
68.936
61.042
1.00
22.85
6

ATOM
3131
CG
LEU
A
681
86.239
67.841
61.125
1.00
25.25
6

ATOM
3132
CD1
LEU
A
681
87.431
68.307
61.944
1.00
25.16
6

ATOM
3133
CD2
LEU
A
681
85.627
66.601
61.721
1.00
23.88
6

ATOM
3134
C
LEU
A
681
82.916
69.631
60.169
1.00
22.54
6

ATOM
3135
O
LEU
A
681
81.842
69.362
60.706
1.00
22.59
8

ATOM
3136
N
LEU
A
682
83.185
70.816
59.640
1.00
24.92
7

ATOM
3137
CA
LEU
A
682
82.219
71.907
59.638
1.00
26.58
6

ATOM
3138
CB
LEU
A
682
82.733
73.035
58.746
1.00
29.58
6

ATOM
3139
CG
LEU
A
682
82.258
74.468
58.971
1.00
33.24
6

ATOM
3140
CD1
LEU
A
682
82.784
75.351
57.857
1.00
31.20
6

ATOM
3141
CD2
LEU
A
682
80.777
74.520
59.015
1.00
33.22
6

ATOM
3142
C
LEU
A
682
80.893
71.381
59.090
1.00
28.13
6

ATOM
3143
O
LEU
A
682
79.844
71.522
59.725
1.00
27.44
8

ATOM
3144
N
LYS
A
683
80.950
70.760
57.914
1.00
27.87
7

ATOM
3145
CA
LYS
A
683
79.762
70.211
57.260
1.00
28.96
6

ATOM
3146
CB
LYS
A
683
80.128
69.655
55.879
1.00
30.63
6

ATOM
3147
CG
LYS
A
683
80.418
70.697
54.807
1.00
33.89
6

ATOM
3148
CD
LYS
A
683
80.898
70.009
53.524
1.00
39.63
6

ATOM
3149
CE
LYS
A
683
82.189
69.216
53.775
1.00
41.44
6

ATOM
3150
NZ
LYS
A
683
82.633
68.343
52.633
1.00
43.89
7

ATOM
3151
C
LYS
A
683
78.998
69.128
58.027
1.00
27.32
6

ATOM
3152
O
LYS
A
683
77.775
69.200
58.155
1.00
28.85
8

ATOM
3153
N
ARG
A
684
79.693
68.110
58.519
1.00
25.99
7

ATOM
3154
CA
ARG
A
684
78.993
67.046
59.235
1.00
24.50
6

ATOM
3155
CB
ARG
A
684
79.923
65.845
59.465
1.00
24.46
6

ATOM
3156
CG
ARG
A
684
80.471
65.214
58.166
1.00
24.64
6

ATOM
3157
CD
ARG
A
684
79.350
64.802
57.194
1.00
25.04
6

ATOM
3158
NE
ARG
A
684
78.507
63.740
57.727
1.00
22.67
7

ATOM
3159
CZ
ARG
A
684
78.685
62.444
57.487
1.00
25.99
6

ATOM
3160
NH1
ARG
A
684
79.679
62.038
56.705
1.00
27.19
7

ATOM
3161
NH2
ARG
A
684
77.884
61.547
58.050
1.00
23.41
7

ATOM
3162
C
ARG
A
684
78.409
67.550
60.559
1.00
24.11
6

ATOM
3163
O
ARG
A
684
77.387
67.041
61.030
1.00
24.09
8

ATOM
3164
N
GLY
A
685
79.052
68.557
61.141
1.00
24.81
7

ATOM
3165
CA
GLY
A
685
78.567
69.128
62.386
1.00
25.62
6

ATOM
3166
C
GLY
A
685
77.308
69.937
62.131
1.00
26.02
6

ATOM
3167
O
GLY
A
685
76.388
69.942
62.950
1.00
26.21
8

ATOM
3168
N
LEU
A
686
77.264
70.611
60.983
1.00
25.15
7

ATOM
3169
CA
LEU
A
686
76.101
71.416
60.611
1.00
24.42
6

ATOM
3170
CB
LEU
A
686
76.472
72.422
59.522
1.00
21.60
6

ATOM
3171
CG
LEU
A
686
77.310
73.618
59.983
1.00
21.47
6

ATOM
3172
CD1
LEU
A
686
77.751
74.415
58.772
1.00
21.47
6

ATOM
3173
CD2
LEU
A
686
76.500
74.496
60.936
1.00
21.23
6

ATOM
3174
C
LEU
A
686
74.970
70.533
60.126
1.00
24.96
6

ATOM
3175
O
LEU
A
686
73.794
70.921
60.152
1.00
23.52
8

ATOM
3176
N
ARG
A
687
75.326
69.331
59.703
1.00
26.61
7

ATOM
3177
CA
ARG
A
687
74.344
68.385
59.197
1.00
28.53
6

ATOM
3178
CB
ARG
A
687
75.032
67.397
58.244
1.00
29.39
6

ATOM
3179
CG
ARG
A
687
74.174
66.190
57.858
1.00
35.52
6

ATOM
3180
CD
ARG
A
687
74.407
65.778
56.405
1.00
38.10
6

ATOM
3181
NE
ARG
A
687
75.806
65.915
56.009
1.00
42.37
7

ATOM
3182
CZ
ARG
A
687
76.264
66.843
55.173
1.00
43.67
6

ATOM
3183
NH1
ARG
A
687
75.431
67.724
54.638
1.00
48.16
7

ATOM
3184
NH2
ARG
A
687
77.554
66.895
54.875
1.00
45.13
7

ATOM
3185
C
ARG
A
687
73.604
67.615
60.287
1.00
28.89
6

ATOM
3186
O
ARG
A
687
72.457
67.208
60.102
1.00
29.17
8

ATOM
3187
N
ASN
A
688
74.247
67.425
61.429
1.00
28.40
7

ATOM
3188
CA
ASN
A
688
73.630
66.658
62.497
1.00
26.84
6

ATOM
3189
CB
ASN
A
688
74.149
65.214
62.418
1.00
28.88
6

ATOM
3190
CG
ASN
A
688
73.729
64.371
63.596
1.00
31.06
6

ATOM
3191
OD1
ASN
A
688
74.287
64.491
64.681
1.00
36.66
8

ATOM
3192
ND2
ASN
A
688
72.737
63.511
63.391
1.00
33.45
7

ATOM
3193
C
ASN
A
688
73.887
67.267
63.872
1.00
26.97
6

ATOM
3194
O
ASN
A
688
75.026
67.489
64.257
1.00
25.22
8

ATOM
3195
N
LYS
A
689
72.812
67.512
64.614
1.00
27.02
7

ATOM
3196
CA
LYS
A
689
72.912
68.129
65.935
1.00
26.47
6

ATOM
3197
CB
LYS
A
689
71.512
68.346
66.535
1.00
26.83
6

ATOM
3198
CG
LYS
A
689
70.782
69.573
65.975
1.00
30.57
6

ATOM
3199
CD
LYS
A
689
69.516
69.901
66.772
1.00
28.22
6

ATOM
3200
CE
LYS
A
689
68.833
71.170
66.239
1.00
33.75
6

ATOM
3201
NZ
LYS
A
689
67.757
71.682
67.149
1.00
27.87
7

ATOM
3202
C
LYS
A
689
73.793
67.416
66.955
1.00
23.72
6

ATOM
3203
O
LYS
A
689
74.439
68.079
67.759
1.00
23.16
8

ATOM
3204
N
ARG
A
690
73.821
66.086
66.938
1.00
23.70
7

ATOM
3205
CA
ARG
A
690
74.646
65.363
67.905
1.00
23.00
6

ATOM
3206
CB
ARG
A
690
74.274
63.876
67.963
1.00
23.52
6

ATOM
3207
CG
ARG
A
690
74.962
63.174
69.153
1.00
28.33
6

ATOM
3208
CD
ARG
A
690
74.641
61.689
69.274
1.00
28.61
6

ATOM
3209
NE
ARG
A
690
75.443
61.050
70.322
1.00
28.35
7

ATOM
3210
CZ
ARG
A
690
75.213
61.148
71.634
1.00
31.84
6

ATOM
3211
NH1
ARG
A
690
74.189
61.861
72.099
1.00
30.60
7

ATOM
3212
NH2
ARG
A
690
76.015
60.528
72.492
1.00
29.15
7

ATOM
3213
C
ARG
A
690
76.126
65.514
67.547
1.00
25.33
6

ATOM
3214
O
ARG
A
690
76.988
65.632
68.432
1.00
23.93
8

ATOM
3215
N
ILE
A
691
76.431
65.503
66.250
1.00
20.50
7

ATOM
3216
CA
ILE
A
691
77.810
65.688
65.833
1.00
19.45
6

ATOM
3217
CB
ILE
A
691
78.009
65.356
64.336
1.00
19.37
6

ATOM
3218
CG2
ILE
A
691
79.376
65.857
63.870
1.00
18.47
6

ATOM
3219
CG1
ILE
A
691
77.881
63.838
64.133
1.00
19.36
6

ATOM
3220
CD1
ILE
A
691
77.773
63.399
62.665
1.00
21.08
6

ATOM
3221
C
ILE
A
691
78.210
67.134
66.091
1.00
20.50
6

ATOM
3222
O
ILE
A
691
79.326
67.405
66.535
1.00
18.96
8

ATOM
3223
N
GLY
A
692
77.300
68.067
65.804
1.00
20.94
7

ATOM
3224
CA
GLY
A
692
77.595
69.474
66.022
1.00
21.64
6

ATOM
3225
C
GLY
A
692
77.870
69.771
67.492
1.00
21.61
6

ATOM
3226
O
GLY
A
692
78.757
70.553
67.836
1.00
21.78
8

ATOM
3227
N
HIS
A
693
77.097
69.133
68.358
1.00
24.01
7

ATOM
3228
CA
HIS
A
693
77.233
69.312
69.796
1.00
23.94
6

ATOM
3229
CB
HIS
A
693
76.186
68.479
70.536
1.00
23.26
6

ATOM
3230
CG
HIS
A
693
76.541
68.215
71.966
1.00
26.61
6

ATOM
3231
CD2
HIS
A
693
77.138
67.150
72.557
1.00
24.10
6

ATOM
3232
ND1
HIS
A
693
76.335
69.142
72.966
1.00
23.94
7

ATOM
3233
CE1
HIS
A
693
76.789
68.661
74.111
1.00
23.91
6

ATOM
3234
NE2
HIS
A
693
77.280
67.455
73.889
1.00
24.99
7

ATOM
3235
C
HIS
A
693
78.621
68.918
70.285
1.00
23.88
6

ATOM
3236
O
HIS
A
693
79.284
69.689
70.986
1.00
21.95
8

ATOM
3237
N
PHE
A
694
79.056
67.711
69.940
1.00
22.55
7

ATOM
3238
CA
PHE
A
694
80.369
67.260
70.372
1.00
21.87
6

ATOM
3239
CB
PHE
A
694
80.506
65.749
70.177
1.00
21.31
6

ATOM
3240
CG
PHE
A
694
79.825
64.945
71.247
1.00
21.68
6

ATOM
3241
CD1
PHE
A
694
78.583
64.357
71.022
1.00
21.60
6

ATOM
3242
CD2
PHE
A
694
80.427
64.785
72.493
1.00
23.10
6

ATOM
3243
CE1
PHE
A
694
77.950
63.619
72.019
1.00
20.83
6

ATOM
3244
CE2
PHE
A
694
79.800
64.043
73.506
1.00
19.98
6

ATOM
3245
CZ
PHE
A
694
78.559
63.460
73.266
1.00
21.79
6

ATOM
3246
C
PHE
A
694
81.491
68.020
69.660
1.00
23.01
6

ATOM
3247
O
PHE
A
694
82.529
68.302
70.257
1.00
22.44
8

ATOM
3248
N
LEU
A
695
81.285
68.363
68.391
1.00
20.00
7

ATOM
3249
CA
LEU
A
695
82.290
69.128
67.664
1.00
18.25
6

ATOM
3250
CB
LEU
A
695
81.786
69.470
66.261
1.00
19.55
6

ATOM
3251
CG
LEU
A
695
82.786
70.204
65.356
1.00
21.85
6

ATOM
3252
CD1
LEU
A
695
83.968
69.303
65.065
1.00
20.89
6

ATOM
3253
CD2
LEU
A
695
82.108
70.626
64.050
1.00
21.95
6

ATOM
3254
C
LEU
A
695
82.552
70.427
68.447
1.00
19.08
6

ATOM
3255
O
LEU
A
695
83.694
70.878
68.568
1.00
16.96
8

ATOM
3256
N
PHE
A
696
81.479
71.019
68.972
1.00
18.16
7

ATOM
3257
CA
PHE
A
696
81.567
72.258
69.761
1.00
19.05
6

ATOM
3258
CB
PHE
A
696
80.172
72.649
70.287
1.00
17.13
6

ATOM
3259
CG
PHE
A
696
80.176
73.824
71.224
1.00
21.10
6

ATOM
3260
CD1
PHE
A
696
80.023
75.124
70.742
1.00
20.90
6

ATOM
3261
CD2
PHE
A
696
80.320
73.631
72.604
1.00
18.88
6

ATOM
3262
CE1
PHE
A
696
80.011
76.206
71.606
1.00
23.80
6

ATOM
3263
CE2
PHE
A
696
80.310
74.708
73.475
1.00
22.82
6

ATOM
3264
CZ
PHE
A
696
80.155
76.000
72.984
1.00
22.92
6

ATOM
3265
C
PHE
A
696
82.511
72.067
70.947
1.00
18.13
6

ATOM
3266
O
PHE
A
696
83.480
72.801
71.109
1.00
19.82
8

ATOM
3267
N
TRP
A
697
82.218
71.066
71.770
1.00
17.27
7

ATOM
3268
CA
TRP
A
697
83.026
70.810
72.960
1.00
21.12
6

ATOM
3269
CB
TRP
A
697
82.293
69.825
73.876
1.00
19.20
6

ATOM
3270
CG
TRP
A
697
81.111
70.497
74.525
1.00
24.42
6

ATOM
3271
CD2
TRP
A
697
81.165
71.541
75.502
1.00
23.09
6

ATOM
3272
CE2
TRP
A
697
79.837
71.947
75.759
1.00
24.00
6

ATOM
3273
CE3
TRP
A
697
82.212
72.175
76.186
1.00
24.06
6

ATOM
3274
CD1
TRP
A
697
79.781
70.309
74.241
1.00
24.37
6

ATOM
3275
NE1
TRP
A
697
79.010
71.181
74.978
1.00
22.76
7

ATOM
3276
CZ2
TRP
A
697
79.529
72.956
76.671
1.00
25.31
6

ATOM
3277
CZ3
TRP
A
697
81.906
73.179
77.092
1.00
25.77
6

ATOM
3278
CH2
TRP
A
697
80.575
73.560
77.328
1.00
24.27
6

ATOM
3279
C
TRP
A
697
84.459
70.364
72.698
1.00
20.13
6

ATOM
3280
O
TRP
A
697
85.359
70.718
73.468
1.00
18.09
8

ATOM
3281
N
PHE
A
698
84.676
69.620
71.610
1.00
18.95
7

ATOM
3282
CA
PHE
A
698
86.019
69.155
71.254
1.00
19.41
6

ATOM
3283
CB
PHE
A
698
85.965
68.062
70.170
1.00
17.87
6

ATOM
3284
CG
PHE
A
698
85.440
66.721
70.654
1.00
20.65
6

ATOM
3285
CD1
PHE
A
698
86.268
65.600
70.660
1.00
21.11
6

ATOM
3286
CD2
PHE
A
698
84.131
66.579
71.125
1.00
22.12
6

ATOM
3287
CE1
PHE
A
698
85.815
64.360
71.125
1.00
20.90
6

ATOM
3288
CE2
PHE
A
698
83.659
65.343
71.595
1.00
22.84
6

ATOM
3289
CZ
PHE
A
698
84.505
64.231
71.593
1.00
22.20
6

ATOM
3290
C
PHE
A
698
86.853
70.328
70.746
1.00
18.83
6

ATOM
3291
O
PHE
A
698
88.054
70.389
70.984
1.00
20.49
8

ATOM
3292
N
LEU
A
699
86.227
71.254
70.022
1.00
19.21
7

ATOM
3293
CA
LEU
A
699
86.947
72.420
69.528
1.00
17.18
6

ATOM
3294
CB
LEU
A
699
86.145
73.136
68.420
1.00
19.36
6

ATOM
3295
CG
LEU
A
699
86.012
72.460
67.045
1.00
18.10
6

ATOM
3296
CD1
LEU
A
699
85.039
73.244
66.146
1.00
19.34
6

ATOM
3297
CD2
LEU
A
699
87.377
72.392
66.394
1.00
19.57
6

ATOM
3298
C
LEU
A
699
87.197
73.396
70.683
1.00
19.71
6

ATOM
3299
O
LEU
A
699
88.300
73.924
70.833
1.00
20.65
8

ATOM
3300
N
ARG
A
700
86.177
73.613
71.509
1.00
19.34
7

ATOM
3301
CA
ARG
A
700
86.301
74.547
72.629
1.00
21.27
6

ATOM
3302
CB
ARG
A
700
84.936
74.715
73.344
1.00
18.59
6

ATOM
3303
CG
ARG
A
700
84.893
75.913
74.328
1.00
22.00
6

ATOM
3304
CD
ARG
A
700
83.470
76.244
74.827
1.00
23.77
6

ATOM
3305
NE
ARG
A
700
83.512
77.308
75.825
1.00
27.31
7

ATOM
3306
CZ
ARG
A
700
83.871
77.139
77.097
1.00
30.05
6

ATOM
3307
NH1
ARG
A
700
84.207
75.932
77.543
1.00
28.62
7

ATOM
3308
NH2
ARG
A
700
83.932
78.190
77.917
1.00
27.43
7

ATOM
3309
C
ARG
A
700
87.379
74.067
73.614
1.00
20.58
6

ATOM
3310
O
ARG
A
700
88.092
74.870
74.220
1.00
21.40
8

ATOM
3311
N
SER
A
701
87.510
72.750
73.737
1.00
21.94
7

ATOM
3312
CA
SER
A
701
88.490
72.145
74.624
1.00
23.81
6

ATOM
3313
CB
SER
A
701
88.365
70.623
74.585
1.00
24.36
6

ATOM
3314
OG
SER
A
701
89.447
70.040
75.277
1.00
26.31
8

ATOM
3315
C
SER
A
701
89.910
72.540
74.258
1.00
24.59
6

ATOM
3316
O
SER
A
701
90.751
72.791
75.135
1.00
23.14
8

ATOM
3317
N
GLU
A
702
90.180
72.587
72.959
1.00
23.77
7

ATOM
3318
CA
GLU
A
702
91.500
72.969
72.483
1.00
24.54
6

ATOM
3319
CB
GLU
A
702
91.763
72.427
71.067
1.00
22.85
6

ATOM
3320
CG
GLU
A
702
91.865
70.908
70.992
1.00
26.41
6

ATOM
3321
CD
GLU
A
702
93.026
70.334
71.785
1.00
31.08
6

ATOM
3322
OE1
GLU
A
702
94.005
71.074
71.995
1.00
34.68
8

ATOM
3323
OE2
GLU
A
702
92.940
69.162
72.204
1.00
28.17
8

ATOM
3324
C
GLU
A
702
91.673
74.492
72.482
1.00
20.46
6

ATOM
3325
O
GLU
A
702
92.753
74.992
72.765
1.00
23.16
8

ATOM
3326
N
ILE
A
703
90.614
75.225
72.162
1.00
19.71
7

ATOM
3327
CA
ILE
A
703
90.695
76.682
72.140
1.00
20.51
6

ATOM
3328
CB
ILE
A
703
89.375
77.300
71.588
1.00
22.47
6

ATOM
3329
CG2
ILE
A
703
89.411
78.807
71.644
1.00
19.59
6

ATOM
3330
CG1
ILE
A
703
89.155
76.825
70.143
1.00
18.98
6

ATOM
3331
CD1
ILE
A
703
87.720
76.945
69.662
1.00
21.54
6

ATOM
3332
C
ILE
A
703
90.994
77.243
73.537
1.00
22.72
6

ATOM
3333
O
ILE
A
703
91.671
78.264
73.669
1.00
24.07
8

ATOM
3334
N
ALA
A
704
90.478
76.580
74.572
1.00
24.28
7

ATOM
3335
CA
ALA
A
704
90.652
77.010
75.957
1.00
26.37
6

ATOM
3336
CB
ALA
A
704
89.600
76.341
76.825
1.00
20.55
6

ATOM
3337
C
ALA
A
704
92.036
76.742
76.518
1.00
28.55
6

ATOM
3338
O
ALA
A
704
92.429
77.357
77.509
1.00
30.75
8

ATOM
3339
N
GLN
A
705
92.806
75.836
75.906
1.00
29.09
7

ATOM
3340
CA
GLN
A
705
94.087
75.490
76.529
1.00
29.22
6

ATOM
3341
CB
GLN
A
705
93.914
74.156
77.256
1.00
29.33
6

ATOM
3342
CG
GLN
A
705
93.412
73.064
76.336
1.00
31.10
6

ATOM
3343
CD
GLN
A
705
92.960
71.824
77.083
1.00
33.03
6

ATOM
3344
OE1
GLN
A
705
93.757
71.180
77.763
1.00
33.61
8

ATOM
3345
NE2
GLN
A
705
91.735
71.328
77.112
1.00
30.98
7

ATOM
3346
C
GLN
A
705
95.295
75.371
75.602
1.00
29.84
6

ATOM
3347
O
GLN
A
705
96.438
75.243
76.070
1.00
32.83
8

ATOM
3348
N
SER
A
706
95.078
75.411
74.311
1.00
27.20
7

ATOM
3349
CA
SER
A
706
96.225
75.233
73.453
1.00
25.05
6

ATOM
3350
CB
SER
A
706
95.926
74.156
72.429
1.00
25.33
6

ATOM
3351
OG
SER
A
706
96.921
74.124
71.417
1.00
23.33
8

ATOM
3352
C
SER
A
706
96.637
76.521
72.790
1.00
23.58
6

ATOM
3353
O
SER
A
706
95.958
77.021
71.898
1.00
21.82
8

ATOM
3354
N
ARG
A
707
97.428
76.846
73.355
1.00
23.04
7

ATOM
3355
CA
ARG
A
707
97.968
78.121
72.930
1.00
23.28
6

ATOM
3356
CB
ARG
A
707
99.034
78.646
73.895
1.00
25.15
6

ATOM
3357
CG
ARG
A
707
98.626
78.589
75.359
1.00
32.56
6

ATOM
3358
CD
ARG
A
707
99.572
79.413
76.209
1.00
37.92
6

ATOM
3359
NE
ARG
A
707
99.218
80.832
76.217
1.00
42.94
7

ATOM
3360
CZ
ARG
A
707
98.787
81.483
77.299
1.00
46.51
6

ATOM
3361
NH1
ARG
A
707
98.655
80.834
78.452
1.00
46.28
7

ATOM
3362
NH2
ARG
A
707
98.503
82.780
77.240
1.00
45.86
7

ATOM
3363
C
ARG
A
707
98.555
77.945
71.530
1.00
23.81
6

ATOM
3364
O
ARG
A
707
98.509
78.857
70.700
1.00
21.00
8

ATOM
3365
N
HIS
A
708
99.170
76.722
70.951
1.00
22.57
7

ATOM
3366
CA
HIS
A
708
99.610
76.301
69.612
1.00
22.49
6

ATOM
3367
CB
HIS
A
708
100.333
74.942
69.681
1.00
24.79
6

ATOM
3368
CG
HIS
A
708
101.510
74.920
70.616
1.00
23.46
6

ATOM
3369
CD2
HIS
A
708
102.844
74.938
70.371
1.00
25.51
6

ATOM
3370
ND1
HIS
A
708
101.375
74.888
71.989
1.00
23.49
7

ATOM
3371
CE1
HIS
A
708
102.573
74.889
72.548
1.00
25.13
6

ATOM
3372
NE2
HIS
A
708
103.482
74.920
71.591
1.00
27.29
7

ATOM
3373
C
HIS
A
708
98.505
76.227
68.541
1.00
22.67
6

ATOM
3374
O
HIS
A
708
98.768
76.494
67.363
1.00
19.35
8

ATOM
3375
N
TYR
A
709
97.284
75.873
68.933
1.00
19.56
7

ATOM
3376
CA
TYR
A
709
96.193
75.752
67.954
1.00
22.22
6

ATOM
3377
CB
TYR
A
709
95.896
74.266
67.691
1.00
23.12
6

ATOM
3378
CG
TYR
A
709
97.069
73.525
67.082
1.00
22.87
6

ATOM
3379
CD1
TYR
A
709
97.938
72.769
67.874
1.00
21.66
6

ATOM
3380
CE1
TYR
A
709
99.057
72.130
67.304
1.00
22.18
6

ATOM
3381
CD2
TYR
A
709
97.336
73.631
65.719
1.00
22.51
6

ATOM
3382
CE2
TYR
A
709
98.439
73.013
65.144
1.00
20.91
6

ATOM
3383
CZ
TYR
A
709
99.295
72.265
65.940
1.00
20.05
6

ATOM
3384
OH
TYR
A
709
100.391
71.690
65.360
1.00
22.66
8

ATOM
3385
C
TYR
A
709
94.866
76.460
68.251
1.00
19.40
6

ATOM
3386
O
TYR
A
709
93.936
76.395
67.436
1.00
19.16
8

ATOM
3387
N
GLN
A
710
94.762
77.143
69.390
1.00
19.21
7

ATOM
3388
CA
GLN
A
710
93.496
77.796
69.712
1.00
21.01
6

ATOM
3389
CB
GLN
A
710
93.578
78.545
71.051
1.00
21.79
6

ATOM
3390
CG
GLN
A
710
94.201
79.930
70.981
1.00
22.50
6

ATOM
3391
CD
GLN
A
710
94.564
80.477
72.357
1.00
25.58
6

ATOM
3392
OE1
GLN
A
710
95.321
81.431
72.466
1.00
28.28
8

ATOM
3393
NE2
GLN
A
710
94.023
79.867
73.407
1.00
22.40
7

ATOM
3394
C
GLN
A
710
93.022
78.744
68.616
1.00
18.17
6

ATOM
3395
O
GLN
A
710
91.825
78.850
68.382
1.00
21.47
8

ATOM
3396
N
GLN
A
711
93.947
79.407
67.925
1.00
19.34
7

ATOM
3397
CA
GLN
A
711
93.568
80.352
66.868
1.00
20.41
6

ATOM
3398
CB
GLN
A
711
94.789
81.119
66.371
1.00
22.98
6

ATOM
3399
CG
GLN
A
711
94.965
82.491
66.990
1.00
24.72
6

ATOM
3400
CD
GLN
A
711
96.273
83.121
66.573
1.00
26.38
6

ATOM
3401
OE1
GLN
A
711
97.350
82.650
66.956
1.00
26.35
8

ATOM
3402
NE2
GLN
A
711
96.196
84.176
65.760
1.00
23.68
7

ATOM
3403
C
GLN
A
711
92.891
79.658
65.687
1.00
21.02
6

ATOM
3404
O
GLN
A
711
91.822
80.089
65.212
1.00
16.34
8

ATOM
3405
N
ARG
A
712
93.525
78.598
65.195
1.00
20.62
7

ATOM
3406
CA
ARG
A
712
92.949
77.830
64.095
1.00
18.44
6

ATOM
3407
CB
ARG
A
712
93.897
76.713
63.645
1.00
20.40
6

ATOM
3408
CG
ARG
A
712
93.266
75.746
62.631
1.00
20.81
6

ATOM
3409
CD
ARG
A
712
94.254
74.662
62.182
1.00
23.42
6

ATOM
3410
NE
ARG
A
712
95.397
75.187
61.424
1.00
20.56
7

ATOM
3411
CZ
ARG
A
712
96.423
74.436
61.023
1.00
24.19
6

ATOM
3412
NH1
ARG
A
712
96.448
73.136
61.314
1.00
23.05
7

ATOM
3413
NH2
ARG
A
712
97.415
74.965
60.318
1.00
21.46
7

ATOM
3414
C
ARG
A
712
91.627
77.216
64.532
1.00
19.56
6

ATOM
3415
O
ARG
A
712
90.624
77.337
63.834
1.00
20.88
8

ATOM
3416
N
PHE
A
713
91.598
76.568
65.695
1.00
17.14
7

ATOM
3417
CA
PHE
A
713
90.355
75.955
66.138
1.00
17.40
6

ATOM
3418
CB
PHE
A
713
90.588
75.081
67.391
1.00
23.04
6

ATOM
3419
CG
PHE
A
713
91.271
73.758
67.106
1.00
23.61
6

ATOM
3420
CD1
PHE
A
713
92.475
73.434
67.714
1.00
29.71
6

ATOM
3421
CD2
PHE
A
713
90.698
72.834
66.238
1.00
29.09
6

ATOM
3422
CE1
PHE
A
713
93.104
72.205
67.465
1.00
28.30
6

ATOM
3423
CE2
PHE
A
713
91.318
71.603
65.981
1.00
28.33
6

ATOM
3424
CZ
PHE
A
713
92.520
71.290
66.595
1.00
26.28
6

ATOM
3425
C
PHE
A
713
89.236
76.979
66.416
1.00
19.45
6

ATOM
3426
O
PHE
A
713
88.060
76.664
66.251
1.00
18.59
8

ATOM
3427
N
ALA
A
714
89.588
78.193
66.837
1.00
17.12
7

ATOM
3428
CA
ALA
A
714
88.559
79.195
67.129
1.00
19.17
6

ATOM
3429
CB
ALA
A
714
89.184
80.426
67.826
1.00
14.73
6

ATOM
3430
C
ALA
A
714
87.834
79.629
65.851
1.00
18.89
6

ATOM
3431
O
ALA
A
714
86.634
79.879
65.856
1.00
19.59
8

ATOM
3432
N
VAL
A
715
88.575
79.700
64.758
1.00
22.18
7

ATOM
3433
CA
VAL
A
715
88.011
80.109
63.480
1.00
23.92
6

ATOM
3434
CB
VAL
A
715
89.142
80.379
62.459
1.00
27.54
6

ATOM
3435
CG1
VAL
A
715
88.568
80.590
61.074
1.00
28.34
6

ATOM
3436
CG2
VAL
A
715
89.919
81.623
62.881
1.00
29.51
6

ATOM
3437
C
VAL
A
715
87.043
79.059
62.944
1.00
24.22
6

ATOM
3438
O
VAL
A
715
86.005
79.391
62.381
1.00
26.51
8

ATOM
3439
N
ILE
A
716
87.377
77.787
63.115
1.00
21.55
7

ATOM
3440
CA
ILE
A
716
86.488
76.731
62.655
1.00
20.82
6

ATOM
3441
CB
ILE
A
716
87.188
75.361
62.699
1.00
21.53
6

ATOM
3442
CG2
ILE
A
716
86.212
74.265
62.273
1.00
20.74
6

ATOM
3443
CG1
ILE
A
716
88.431
75.394
61.800
1.00
20.45
6

ATOM
3444
CD1
ILE
A
716
89.329
74.161
61.936
1.00
25.64
6

ATOM
3445
C
ILE
A
716
85.236
76.675
63.529
1.00
21.15
6

ATOM
3446
O
ILE
A
716
84.141
76.423
63.038
1.00
19.24
8

ATOM
3447
N
LEU
A
717
85.397
76.916
64.830
1.00
20.88
7

ATOM
3448
CA
LEU
A
717
84.254
76.877
65.736
1.00
23.03
6

ATOM
3449
CB
LEU
A
717
84.704
77.003
67.201
1.00
22.06
6

ATOM
3450
CG
LEU
A
717
83.956
76.220
68.296
1.00
27.45
6

ATOM
3451
CD1
LEU
A
717
84.009
77.018
69.581
1.00
24.72
6

ATOM
3452
CD2
LEU
A
717
82.511
75.941
67.926
1.00
26.80
6

ATOM
3453
C
LEU
A
717
83.314
78.027
65.397
1.00
22.17
6

ATOM
3454
O
LEU
A
717
82.108
77.834
65.316
1.00
21.03
8

ATOM
3455
N
GLU
A
718
83.861
79.230
65.216
1.00
25.23
7

ATOM
3456
CA
GLU
A
718
83.009
80.366
64.871
1.00
24.56
6

ATOM
3457
CB
GLU
A
718
83.824
81.624
64.566
1.00
24.34
6

ATOM
3458
CG
GLU
A
718
82.917
82.743
64.019
1.00
27.28
6

ATOM
3459
CD
GLU
A
718
83.660
83.895
63.388
1.00
30.88
6

ATOM
3460
OE1
GLU
A
718
84.622
83.646
62.630
1.00
30.95
8

ATOM
3461
OE2
GLU
A
718
83.261
85.056
63.633
1.00
34.67
8

ATOM
3462
C
GLU
A
718
82.182
80.019
63.631
1.00
24.39
6

ATOM
3463
O
GLU
A
718
80.984
80.284
63.581
1.00
25.59
8

ATOM
3464
N
ALA
A
719
82.827
79.423
62.633
1.00
24.55
7

ATOM
3465
CA
ALA
A
719
82.132
79.047
61.404
1.00
23.14
6

ATOM
3466
CB
ALA
A
719
83.104
78.395
60.424
1.00
19.50
6

ATOM
3467
C
ALA
A
719
80.951
78.119
61.682
1.00
22.38
6

ATOM
3468
O
ALA
A
719
79.888
78.248
61.067
1.00
22.07
8

ATOM
3469
N
TYR
A
720
81.135
77.178
62.599
1.00
23.16
7

ATOM
3470
CA
TYR
A
720
80.064
76.254
62.958
1.00
22.54
6

ATOM
3471
CB
TYR
A
720
80.610
75.110
63.827
1.00
21.12
6

ATOM
3472
CG
TYR
A
720
79.521
74.270
64.466
1.00
20.52
6

ATOM
3473
CD1
TYR
A
720
78.816
73.314
63.731
1.00
19.63
6

ATOM
3474
CE1
TYR
A
720
77.751
72.604
64.305
1.00
20.33
6

ATOM
3475
CD2
TYR
A
720
79.143
74.492
65.796
1.00
19.63
6

ATOM
3476
CE2
TYR
A
720
78.095
73.800
66.374
1.00
20.31
6

ATOM
3477
CZ
TYR
A
720
77.398
72.858
65.631
1.00
21.58
6

ATOM
3478
OH
TYR
A
720
76.345
72.189
66.214
1.00
23.51
8

ATOM
3479
C
TYR
A
720
78.957
76.989
63.732
1.00
23.72
6

ATOM
3480
O
TYR
A
720
77.768
76.774
63.496
1.00
22.32
8

ATOM
3481
N
LEU
A
721
79.348
77.853
64.661
1.00
24.22
7

ATOM
3482
CA
LEU
A
721
78.355
78.573
65.452
1.00
26.99
6

ATOM
3483
CB
LEU
A
721
79.039
79.410
66.537
1.00
24.63
6

ATOM
3484
CG
LEU
A
721
79.661
78.576
67.673
1.00
25.99
6

ATOM
3485
CD1
LEU
A
721
80.298
79.490
68.709
1.00
25.48
6

ATOM
3486
CD2
LEU
A
721
78.580
77.725
68.323
1.00
22.70
6

ATOM
3487
C
LEU
A
721
77.460
79.459
64.588
1.00
28.32
6

ATOM
3488
O
LEU
A
721
76.278
79.624
64.892
1.00
32.28
8

ATOM
3489
N
ARG
A
722
78.012
80.023
63.515
1.00
28.59
7

ATOM
3490
CA
ARG
A
722
77.229
80.879
62.625
1.00
27.58
6

ATOM
3491
CB
ARG
A
722
78.148
81.738
61.742
1.00
26.26
6

ATOM
3492
CG
ARG
A
722
78.561
83.060
62.369
1.00
27.58
6

ATOM
3493
CD
ARG
A
722
79.504
83.858
61.467
1.00
26.00
6

ATOM
3494
NE
ARG
A
722
79.956
85.096
62.105
1.00
28.55
7

ATOM
3495
CZ
ARG
A
722
79.230
86.209
62.201
1.00
31.16
6

ATOM
3496
NH1
ARG
A
722
78.006
86.258
61.692
1.00
32.64
7

ATOM
3497
NH2
ARG
A
722
79.721
87.271
62.826
1.00
29.66
7

ATOM
3498
C
ARG
A
722
76.266
80.088
61.737
1.00
28.76
6

ATOM
3499
O
ARG
A
722
75.571
80.662
60.903
1.00
29.86
8

ATOM
3500
N
GLY
A
723
76.214
78.777
61.919
1.00
27.73
7

ATOM
3501
CA
GLY
A
723
75.316
77.972
61.116
1.00
27.44
6

ATOM
3502
C
GLY
A
723
74.527
76.896
61.846
1.00
26.60
6

ATOM
3503
O
GLY
A
723
73.674
76.258
61.240
1.00
26.55
8

ATOM
3504
N
CYS
A
724
74.782
76.684
63.136
1.00
26.94
7

ATOM
3505
CA
CYS
A
724
74.057
75.641
63.874
1.00
25.15
6

ATOM
3506
CB
CYS
A
724
74.781
75.307
65.190
1.00
25.35
6

ATOM
3507
SG
CYS
A
724
74.966
76.728
66.319
1.00
25.08
16

ATOM
3508
C
CYS
A
724
72.592
75.980
64.182
1.00
28.42
6

ATOM
3509
O
CYS
A
724
71.781
75.080
64.442
1.00
26.43
8

ATOM
3510
N
GLY
A
725
72.280
77.267
64.158
1.00
30.59
7

ATOM
3511
CA
GLY
A
725
70.938
77.795
64.374
1.00
32.14
6

ATOM
3512
C
GLY
A
725
70.704
78.337
65.794
1.00
32.94
6

ATOM
3513
O
GLY
A
725
71.508
78.102
66.690
1.00
33.45
8

ATOM
3514
N
THR
A
726
69.596
79.046
65.979
1.00
35.63
7

ATOM
3515
CA
THR
A
726
69.298
79.622
67.291
1.00
34.78
6

ATOM
3516
CB
THR
A
726
68.360
80.832
67.079
1.00
36.55
6

ATOM
3517
OG1
THR
A
726
67.025
80.354
66.947
1.00
41.00
8

ATOM
3518
CG2
THR
A
726
68.748
81.604
65.820
1.00
36.19
6

ATOM
3519
C
THR
A
726
68.808
78.595
68.356
1.00
34.05
6

ATOM
3520
O
THR
A
726
69.098
78.827
69.528
1.00
34.11
8

ATOM
3521
N
ALA
A
727
68.089
77.500
68.065
1.00
33.80
7

ATOM
3522
CA
ALA
A
727
67.670
76.533
69.143
1.00
34.58
6

ATOM
3523
CB
ALA
A
727
66.774
75.460
68.563
1.00
34.24
6

ATOM
3524
C
ALA
A
727
68.897
75.895
69.809
1.00
35.51
6

ATOM
3525
O
ALA
A
727
69.021
75.854
71.031
1.00
35.48
8

ATOM
3526
N
MET
A
728
69.784
75.410
68.943
1.00
35.24
7

ATOM
3527
CA
MET
A
728
71.044
74.844
69.365
1.00
33.77
6

ATOM
3528
CB
MET
A
728
71.876
74.327
68.186
1.00
36.98
6

ATOM
3529
CG
MET
A
728
71.256
73.155
67.465
1.00
40.03
6

ATOM
3530
SD
MET
A
728
71.719
71.586
68.229
1.00
47.90
16

ATOM
3531
CE
MET
A
728
73.415
71.445
67.688
1.00
44.52
6

ATOM
3532
C
MET
A
728
71.867
75.902
70.045
1.00
31.36
6

ATOM
3533
O
MET
A
728
72.348
75.740
71.156
1.00
27.87
8

ATOM
3534
N
LEU
A
729
72.012
76.983
69.330
1.00
30.10
7

ATOM
3535
CA
LEU
A
729
72.793
78.094
69.807
1.00
30.76
6

ATOM
3536
CB
LEU
A
729
72.430
79.336
69.044
1.00
31.61
6

ATOM
3537
CG
LEU
A
729
73.206
79.536
67.752
1.00
34.19
6

ATOM
3538
CD1
LEU
A
729
72.832
80.852
67.093
1.00
36.13
6

ATOM
3539
CD2
LEU
A
729
74.703
79.488
68.008
1.00
34.00
6

ATOM
3540
C
LEU
A
729
72.609
78.334
71.258
1.00
31.63
6

ATOM
3541
O
LEU
A
729
73.521
78.786
71.936
1.00
31.40
8

ATOM
3542
N
HIS
A
730
71.448
78.062
71.739
1.00
32.99
7

ATOM
3543
CA
HIS
A
730
71.350
78.350
73.121
1.00
36.17
6

ATOM
3544
CB
HIS
A
730
70.134
79.187
73.333
1.00
40.54
6

ATOM
3545
CG
HIS
A
730
69.213
78.929
74.526
1.00
44.11
6

ATOM
3546
CD2
HIS
A
730
67.867
78.736
74.485
1.00
44.29
6

ATOM
3547
ND1
HIS
A
730
69.591
78.913
75.862
1.00
45.50
7

ATOM
3548
CE1
HIS
A
730
68.501
78.745
76.594
1.00
44.90
6

ATOM
3549
NE2
HIS
A
730
67.460
78.643
75.784
1.00
46.30
7

ATOM
3550
C
HIS
A
730
71.506
77.074
73.913
1.00
33.74
6

ATOM
3551
O
HIS
A
730
72.382
77.001
74.773
1.00
30.61
8

ATOM
3552
N
ASP
A
731
70.696
76.087
73.656
1.00
32.97
7

ATOM
3553
CA
ASP
A
731
70.998
74.919
74.432
1.00
33.98
6

ATOM
3554
CB
ASP
A
731
70.802
73.622
73.657
1.00
37.99
6

ATOM
3555
CG
ASP
A
731
69.355
73.357
73.402
1.00
42.51
6

ATOM
3556
OD1
ASP
A
731
68.502
73.695
74.257
1.00
44.05
8

ATOM
3557
OD2
ASP
A
731
69.041
72.796
72.327
1.00
43.97
8

ATOM
3558
C
ASP
A
731
72.464
75.057
74.805
1.00
32.49
6

ATOM
3559
O
ASP
A
731
72.864
74.787
75.951
1.00
33.78
8

ATOM
3560
N
PHE
A
732
73.282
75.499
73.841
1.00
29.82
7

ATOM
3561
CA
PHE
A
732
74.698
75.633
74.134
1.00
27.64
6

ATOM
3562
CB
PHE
A
732
75.540
76.041
72.918
1.00
27.65
6

ATOM
3563
CG
PHE
A
732
75.895
74.926
71.967
1.00
25.81
6

ATOM
3564
CD1
PHE
A
732
75.759
75.149
70.599
1.00
23.08
6

ATOM
3565
CD2
PHE
A
732
76.319
73.672
72.398
1.00
20.52
6

ATOM
3566
CE1
PHE
A
732
76.070
74.145
69.676
1.00
23.70
6

ATOM
3567
CE2
PHE
A
732
76.604
72.659
71.481
1.00
23.04
6

ATOM
3568
CZ
PHE
A
732
76.496
72.895
70.116
1.00
23.57
6

ATOM
3569
C
PHE
A
732
74.971
76.680
75.179
1.00
28.01
6

ATOM
3570
O
PHE
A
732
75.715
76.429
76.132
1.00
24.31
8

ATOM
3571
N
THR
A
733
74.413
77.853
75.046
1.00
29.61
7

ATOM
3572
CA
THR
A
733
74.775
78.815
76.060
1.00
29.51
6

ATOM
3573
CB
THR
A
733
74.297
80.186
75.594
1.00
31.32
6

ATOM
3574
OG1
THR
A
733
74.473
80.288
74.174
1.00
29.17
8

ATOM
3575
CG2
THR
A
733
75.088
81.270
76.304
1.00
30.83
6

ATOM
3576
C
THR
A
733
74.309
78.341
77.445
1.00
29.80
6

ATOM
3577
O
THR
A
733
75.052
78.499
78.432
1.00
30.30
8

ATOM
3578
N
GLN
A
734
73.101
77.774
77.551
1.00
29.60
7

ATOM
3579
CA
GLN
A
734
72.602
77.296
78.861
1.00
32.46
6

ATOM
3580
CB
GLN
A
734
71.301
76.495
78.724
1.00
35.93
6

ATOM
3581
CG
GLN
A
734
70.018
77.325
78.527
1.00
41.57
6

ATOM
3582
CD
GLN
A
734
69.060
77.246
79.720
1.00
45.73
6

ATOM
3583
OE1
GLN
A
734
68.268
76.307
79.847
1.00
48.38
8

ATOM
3584
NE2
GLN
A
734
68.962
78.132
80.718
1.00
48.03
7

ATOM
3585
C
GLN
A
734
73.670
76.433
79.474
1.00
32.05
6

ATOM
3586
O
GLN
A
734
74.040
76.536
80.634
1.00
30.04
8

ATOM
3587
N
GLN
A
735
74.148
75.564
78.612
1.00
30.98
7

ATOM
3588
CA
GLN
A
735
75.195
74.604
78.921
1.00
30.15
6

ATOM
3589
CB
GLN
A
735
75.604
73.827
77.685
1.00
30.80
6

ATOM
3590
CG
GLN
A
735
75.076
72.412
77.591
1.00
28.02
6

ATOM
3591
CD
GLN
A
735
75.381
71.843
76.237
1.00
29.18
6

ATOM
3592
OE1
GLN
A
735
76.546
71.652
75.864
1.00
27.87
8

ATOM
3593
NE2
GLN
A
735
74.475
71.503
75.323
1.00
29.11
7

ATOM
3594
C
GLN
A
735
76.464
75.283
79.433
1.00
29.53
6

ATOM
3595
O
GLN
A
735
76.971
75.017
80.530
1.00
28.10
8

ATOM
3596
N
VAL
A
736
76.959
76.163
78.576
1.00
29.43
7

ATOM
3597
CA
VAL
A
736
78.175
76.897
78.898
1.00
30.13
6

ATOM
3598
CB
VAL
A
736
78.580
77.832
77.744
1.00
29.01
6

ATOM
3599
CG1
VAL
A
736
79.737
78.726
78.173
1.00
31.28
6

ATOM
3600
CG2
VAL
A
736
78.941
77.027
76.507
1.00
30.67
6

ATOM
3601
C
VAL
A
736
78.019
77.686
80.205
1.00
30.77
6

ATOM
3602
O
VAL
A
736
78.948
77.668
81.034
1.00
31.00
8

ATOM
3603
N
GLN
A
737
76.901
78.367
80.432
1.00
31.96
7

ATOM
3604
CA
GLN
A
737
76.740
79.128
81.666
1.00
34.69
6

ATOM
3605
CB
GLN
A
737
75.407
79.874
81.670
1.00
37.40
6

ATOM
3606
CG
GLN
A
737
75.222
80.771
80.475
1.00
41.15
6

ATOM
3607
CD
GLN
A
737
73.963
81.586
80.563
1.00
42.60
6

ATOM
3608
OE1
GLN
A
737
72.937
81.110
81.048
1.00
44.03
8

ATOM
3609
NE2
GLN
A
737
73.807
82.853
80.173
1.00
45.10
7

ATOM
3610
C
GLN
A
737
76.804
78.194
82.865
1.00
33.27
6

ATOM
3611
O
GLN
A
737
77.386
78.534
83.891
1.00
33.38
8

ATOM
3612
N
VAL
A
738
76.209
77.015
82.734
1.00
33.58
7

ATOM
3613
CA
VAL
A
738
76.235
76.053
83.822
1.00
33.76
6

ATOM
3614
CB
VAL
A
738
75.311
74.843
83.531
1.00
35.79
6

ATOM
3615
CG1
VAL
A
738
75.568
73.707
84.514
1.00
34.22
6

ATOM
3616
CG2
VAL
A
738
73.847
75.269
83.589
1.00
33.91
6

ATOM
3617
C
VAL
A
738
77.639
75.541
84.129
1.00
34.42
6

ATOM
3618
O
VAL
A
738
78.008
75.522
85.300
1.00
33.60
8

ATOM
3619
N
ILE
A
739
78.426
75.115
83.141
1.00
33.03
7

ATOM
3620
CA
ILE
A
739
79.759
74.659
83.454
1.00
34.41
6

ATOM
3621
CB
ILE
A
739
80.569
74.188
82.216
1.00
34.02
6

ATOM
3622
CG2
ILE
A
739
79.780
73.143
81.445
1.00
33.45
6

ATOM
3623
CG1
ILE
A
739
80.923
75.352
81.286
1.00
37.98
6

ATOM
3624
CD1
ILE
A
739
82.181
75.124
80.475
1.00
37.56
6

ATOM
3625
C
ILE
A
739
80.526
75.790
84.053
1.00
34.92
6

ATOM
3626
O
ILE
A
739
80.913
75.777
85.220
1.00
33.63
8

ATOM
3627
N
GLU
A
740
80.742
76.733
83.214
1.00
35.23
7

ATOM
3628
CA
GLU
A
740
81.443
77.896
83.616
1.00
38.19
6

ATOM
3629
CB
GLU
A
740
80.982
79.096
82.819
1.00
41.65
6

ATOM
3630
CG
GLU
A
740
82.123
80.009
82.462
1.00
46.36
6

ATOM
3631
CD
GLU
A
740
82.471
79.918
80.982
1.00
49.35
6

ATOM
3632
OE1
GLU
A
740
81.714
80.473
80.150
1.00
49.25
8

ATOM
3633
OE2
GLU
A
740
83.493
79.287
80.649
1.00
49.69
8

ATOM
3634
C
GLU
A
740
81.254
78.116
85.124
1.00
37.46
6

ATOM
3635
O
GLU
A
740
82.210
78.309
85.863
1.00
37.23
8

ATOM
3636
N
MET
A
741
79.997
78.072
85.538
1.00
38.07
7

ATOM
3637
CA
MET
A
741
79.594
78.250
86.949
1.00
37.88
6

ATOM
3638
CB
MET
A
741
78.077
78.137
87.077
1.00
40.77
6

ATOM
3639
CG
MET
A
741
77.404
79.455
87.402
1.00
47.17
6

ATOM
3640
SD
MET
A
741
75.604
79.335
87.408
1.00
53.04
16

ATOM
3641
CE
MET
A
741
75.183
80.691
88.498
1.00
53.54
6

ATOM
3642
C
MET
A
741
80.237
77.228
87.855
1.00
37.06
6

ATOM
3643
O
MET
A
741
80.919
77.541
88.833
1.00
35.78
8

ATOM
3644
N
LEU
A
742
79.990
75.966
87.493
1.00
34.36
7

ATOM
3645
CA
LEU
A
742
80.489
74.811
88.245
1.00
34.69
6

ATOM
3646
CB
LEU
A
742
79.816
73.531
87.765
1.00
35.38
6

ATOM
3647
CG
LEU
A
742
78.296
73.538
87.925
1.00
36.62
6

ATOM
3648
CD1
LEU
A
742
77.680
72.297
87.299
1.00
36.03
6

ATOM
3649
CD2
LEU
A
742
77.909
73.635
89.379
1.00
35.59
6

ATOM
3650
C
LEU
A
742
82.005
74.725
88.173
1.00
33.04
6

ATOM
3651
O
LEU
A
742
82.631
74.158
89.063
1.00
32.97
8

ATOM
3652
N
GLN
A
743
82.599
75.281
87.140
1.00
35.55
7

ATOM
3653
CA
GLN
A
743
84.051
75.248
87.007
1.00
35.35
6

ATOM
3654
CB
GLN
A
743
84.501
75.753
85.609
1.00
37.19
6

ATOM
3655
CG
GLN
A
743
84.510
74.679
84.512
1.00
41.76
6

ATOM
3656
CD
GLN
A
743
85.140
75.117
83.182
1.00
42.43
6

ATOM
3657
OE1
GLN
A
743
84.853
76.204
82.677
1.00
46.38
8

ATOM
3658
NE2
GLN
A
743
86.002
74.418
82.439
1.00
43.07
7

ATOM
3659
C
GLN
A
743
84.716
76.020
88.170
1.00
35.52
6

ATOM
3660
O
GLN
A
743
85.576
75.468
88.863
1.00
32.88
8

ATOM
3661
N
LYS
A
744
84.300
77.264
88.382
1.00
34.93
7

ATOM
3662
CA
LYS
A
744
84.768
78.096
89.477
1.00
36.49
6

ATOM
3663
CB
LYS
A
744
83.907
79.366
89.552
1.00
37.59
6

ATOM
3664
CG
LYS
A
744
84.526
80.605
90.201
1.00
41.70
6

ATOM
3665
CD
LYS
A
744
83.457
81.596
90.632
1.00
45.14
6

ATOM
3666
CE
LYS
A
744
83.830
83.038
90.305
1.00
46.60
6

ATOM
3667
NZ
LYS
A
744
82.828
84.006
90.826
1.00
46.89
7

ATOM
3668
C
LYS
A
744
84.678
77.316
90.792
1.00
34.45
6

ATOM
3669
O
LYS
A
744
85.678
76.930
91.383
1.00
34.90
8

ATOM
3670
N
VAL
A
745
83.417
77.109
91.237
1.00
34.37
7

ATOM
3671
CA
VAL
A
745
83.113
76.388
92.482
1.00
33.97
6

ATOM
3672
CB
VAL
A
745
81.692
75.817
92.443
1.00
35.32
6

ATOM
3673
CG1
VAL
A
745
81.380
75.084
93.733
1.00
36.09
6

ATOM
3674
CG2
VAL
A
745
80.670
76.920
92.206
1.00
35.76
6

ATOM
3675
C
VAL
A
745
84.101
75.284
92.663
1.00
34.87
6

ATOM
3676
O
VAL
A
745
84.687
75.124
93.732
1.00
34.85
8

ATOM
3677
N
THR
A
746
84.252
74.546
91.618
1.00
33.15
7

ATOM
3678
CA
THR
A
746
85.214
73.528
91.630
1.00
31.91
6

ATOM
3679
CB
THR
A
746
85.376
72.945
90.254
1.00
30.38
6

ATOM
3680
OG1
THR
A
746
84.115
72.898
89.583
1.00
29.21
8

ATOM
3681
CG2
THR
A
746
85.964
71.542
90.345
1.00
29.71
6

ATOM
3682
C
THR
A
746
86.527
74.103
92.141
1.00
33.46
6

ATOM
3683
O
THR
A
746
86.889
73.823
93.278
1.00
30.24
8

ATOM
3684
N
LEU
A
747
87.244
74.908
91.362
1.00
35.48
7

ATOM
3685
CA
LEU
A
747
88.528
75.424
91.844
1.00
38.82
6

ATOM
3686
CB
LEU
A
747
89.133
76.311
90.772
1.00
38.90
6

ATOM
3687
CG
LEU
A
747
89.717
75.531
89.587
1.00
40.10
6

ATOM
3688
CD1
LEU
A
747
90.180
76.488
88.500
1.00
37.87
6

ATOM
3689
CD2
LEU
A
747
90.848
74.632
90.029
1.00
38.63
6

ATOM
3690
C
LEU
A
747
88.536
76.145
93.164
1.00
40.05
6

ATOM
3691
O
LEU
A
747
89.503
76.068
93.903
1.00
41.90
8

ATOM
3692
N
ASP
A
748
87.475
76.838
93.482
1.00
42.06
7

ATOM
3693
CA
ASP
A
748
87.478
77.568
94.750
1.00
42.62
6

ATOM
3694
CB
ASP
A
748
86.179
78.365
94.884
1.00
43.08
6

ATOM
3695
CG
ASP
A
748
86.365
79.832
94.544
1.00
43.20
6

ATOM
3696
OD1
ASP
A
748
87.516
80.290
94.478
1.00
43.54
8

ATOM
3697
OD2
ASP
A
748
85.343
80.519
94.344
1.00
45.60
8

ATOM
3698
C
ASP
A
748
87.602
76.646
95.975
1.00
44.30
6

ATOM
3699
O
ASP
A
748
88.495
76.793
96.794
1.00
44.64
8

ATOM
3700
N
ILE
A
749
86.649
75.693
96.068
1.00
44.84
7

ATOM
3701
CA
ILE
A
749
86.601
74.714
97.146
1.00
45.33
6

ATOM
3702
CB
ILE
A
749
85.620
73.542
96.850
1.00
45.81
6

ATOM
3703
CG2
ILE
A
749
86.193
72.210
97.313
1.00
45.18
6

ATOM
3704
CG1
ILE
A
749
84.268
73.815
97.512
1.00
46.09
6

ATOM
3705
CD1
ILE
A
749
83.748
75.219
97.295
1.00
47.83
6

ATOM
3706
C
ILE
A
749
88.009
74.229
97.339
1.00
46.11
6

ATOM
3707
O
ILE
A
749
88.375
73.591
98.322
1.00
45.22
8

ATOM
3708
N
LYS
A
750
88.799
74.581
96.340
1.00
48.07
7

ATOM
3709
CA
LYS
A
750
90.209
74.293
96.414
1.00
50.37
6

ATOM
3710
CB
LYS
A
750
90.817
73.923
95.033
1.00
50.55
6

ATOM
3711
CG
LYS
A
750
92.140
73.146
95.129
1.00
51.49
6

ATOM
3712
CD
LYS
A
750
92.325
72.097
94.044
1.00
53.90
6

ATOM
3713
CE
LYS
A
750
93.669
71.392
94.178
1.00
53.54
6

ATOM
3714
NZ
LYS
A
750
94.100
70.788
92.890
1.00
54.24
7

ATOM
3715
C
LYS
A
750
90.908
75.498
97.047
1.00
51.73
6

ATOM
3716
O
LYS
A
750
91.640
75.349
98.021
1.00
52.33
8

ATOM
3717
N
SER
A
751
90.678
76.691
96.524
1.00
52.79
7

ATOM
3718
CA
SER
A
751
91.319
77.850
97.125
1.00
54.48
6

ATOM
3719
CB
SER
A
751
90.568
79.138
96.844
1.00
52.83
6

ATOM
3720
OG
SER
A
751
91.002
79.741
95.631
1.00
53.21
8

ATOM
3721
C
SER
A
751
91.384
77.567
98.636
1.00
55.62
6

ATOM
3722
O
SER
A
751
91.181
78.451
99.460
1.00
57.35
8

ATOM
3723
N
LEU
A
752
91.686
76.298
99.003
1.00
56.26
7

ATOM
3724
CA
LEU
A
752
91.623
75.939
100.438
1.00
58.33
6

ATOM
3725
CB
LEU
A
752
90.242
75.303
100.728
1.00
56.15
6

ATOM
3726
CG
LEU
A
752
88.980
76.174
100.841
1.00
55.46
6

ATOM
3727
CD1
LEU
A
752
87.912
75.450
101.645
1.00
54.86
6

ATOM
3728
CD2
LEU
A
752
89.303
77.525
101.468
1.00
54.25
6

ATOM
3729
C
LEU
A
752
92.607
74.929
101.030
1.00
60.54
6

ATOM
3730
O
LEU
A
752
93.694
75.248
101.481
1.00
60.83
8

ATOM
3731
N
SER
A
753
92.144
73.692
100.983
1.00
63.74
7

ATOM
3732
CA
SER
A
753
92.739
72.472
101.563
1.00
67.43
6

ATOM
3733
CB
SER
A
753
91.655
71.397
101.513
1.00
67.80
6

ATOM
3734
OG
SER
A
753
90.391
71.951
101.180
1.00
68.98
8

ATOM
3735
C
SER
A
753
94.061
71.916
100.996
1.00
69.79
6

ATOM
3736
O
SER
A
753
95.109
72.132
101.604
1.00
70.29
8

ATOM
3737
N
SER
A
760
86.519
67.703
105.201
1.00
46.48
7

ATOM
3738
CA
SER
A
760
85.862
67.983
106.463
1.00
44.10
6

ATOM
3739
CB
SER
A
760
86.630
69.064
107.224
1.00
44.56
6

ATOM
3740
OG
SER
A
760
86.562
70.297
106.528
1.00
42.23
8

ATOM
3741
C
SER
A
760
84.459
68.487
106.182
1.00
41.64
6

ATOM
3742
O
SER
A
760
84.131
68.825
105.048
1.00
40.47
8

ATOM
3743
N
SER
A
761
83.636
68.535
107.222
1.00
40.81
7

ATOM
3744
CA
SER
A
761
82.278
69.029
107.083
1.00
40.39
6

ATOM
3745
CB
SER
A
761
81.513
68.854
108.397
1.00
42.54
6

ATOM
3746
OG
SER
A
761
82.158
69.538
109.456
1.00
44.07
8

ATOM
3747
C
SER
A
761
82.375
70.504
106.715
1.00
38.07
6

ATOM
3748
O
SER
A
761
81.432
71.081
106.179
1.00
38.40
8

ATOM
3749
N
GLN
A
762
83.534
71.096
107.000
1.00
36.50
7

ATOM
3750
CA
GLN
A
762
83.789
72.502
106.696
1.00
35.16
6

ATOM
3751
CB
GLN
A
762
85.141
72.939
107.281
1.00
34.85
6

ATOM
3752
CG
GLN
A
762
85.527
74.382
106.971
1.00
37.14
6

ATOM
3753
CD
GLN
A
762
86.845
74.790
107.619
1.00
37.45
6

ATOM
3754
OE1
GLN
A
762
86.957
74.857
108.841
1.00
34.83
8

ATOM
3755
NE2
GLN
A
762
87.850
75.057
106.796
1.00
40.74
7

ATOM
3756
C
GLN
A
762
83.785
72.755
105.186
1.00
33.53
6

ATOM
3757
O
GLN
A
762
83.036
73.602
104.698
1.00
31.40
8

ATOM
3758
N
VAL
A
763
84.618
72.024
104.451
1.00
34.48
7

ATOM
3759
CA
VAL
A
763
84.685
72.204
103.003
1.00
35.27
6

ATOM
3760
CB
VAL
A
763
85.835
71.378
102.368
1.00
36.65
6

ATOM
3761
CG1
VAL
A
763
85.578
69.888
102.534
1.00
37.55
6

ATOM
3762
CG2
VAL
A
763
85.970
71.735
100.892
1.00
35.79
6

ATOM
3763
C
VAL
A
763
83.367
71.813
102.341
1.00
35.57
6

ATOM
3764
O
VAL
A
763
82.966
72.408
101.342
1.00
35.71
8

ATOM
3765
N
ILE
A
764
82.688
70.813
102.891
1.00
36.41
7

ATOM
3766
CA
ILE
A
764
81.415
70.411
102.310
1.00
38.31
6

ATOM
3767
CB
ILE
A
764
80.910
69.077
102.894
1.00
38.35
6

ATOM
3768
CG2
ILE
A
764
79.478
68.813
102.432
1.00
39.79
6

ATOM
3769
CG1
ILE
A
764
81.835
67.938
102.437
1.00
40.32
6

ATOM
3770
CD1
ILE
A
764
81.384
66.538
102.851
1.00
39.50
6

ATOM
3771
C
ILE
A
764
80.407
71.526
102.562
1.00
38.85
6

ATOM
3772
O
ILE
A
764
79.627
71.880
101.671
1.00
39.16
8

ATOM
3773
N
SER
A
765
80.440
72.094
103.765
1.00
38.04
7

ATOM
3774
CA
SER
A
765
79.540
73.190
104.108
1.00
36.94
6

ATOM
3775
CB
SER
A
765
79.800
73.670
105.541
1.00
37.54
6

ATOM
3776
OG
SER
A
765
79.144
74.904
105.809
1.00
34.49
8

ATOM
3777
C
SER
A
765
79.780
74.339
103.133
1.00
36.35
6

ATOM
3778
O
SER
A
765
78.842
74.960
102.640
1.00
37.12
8

ATOM
3779
N
GLN
A
766
81.050
74.613
102.857
1.00
36.40
7

ATOM
3780
CA
GLN
A
766
81.422
75.679
101.942
1.00
36.55
6

ATOM
3781
CB
GLN
A
766
82.939
75.871
101.965
1.00
39.15
6

ATOM
3782
CG
GLN
A
766
83.476
76.440
103.273
1.00
42.58
6

ATOM
3783
CD
GLN
A
766
83.090
77.900
103.496
1.00
46.15
6

ATOM
3784
OE1
GLN
A
766
83.349
78.468
104.560
1.00
48.85
8

ATOM
3785
NE2
GLN
A
766
82.475
78.517
102.489
1.00
49.82
7

ATOM
3786
C
GLN
A
766
80.951
75.366
100.520
1.00
36.58
6

ATOM
3787
O
GLN
A
766
80.649
76.272
99.742
1.00
34.87
8

ATOM
3788
N
LEU
A
767
80.899
74.082
100.182
1.00
35.53
7

ATOM
3789
CA
LEU
A
767
80.448
73.669
98.854
1.00
34.74
6

ATOM
3790
CB
LEU
A
767
80.677
72.166
98.630
1.00
32.27
6

ATOM
3791
CG
LEU
A
767
80.722
71.622
97.186
1.00
33.66
6

ATOM
3792
CD1
LEU
A
767
80.246
70.169
97.185
1.00
32.28
6

ATOM
3793
CD2
LEU
A
767
79.860
72.439
96.255
1.00
29.50
6

ATOM
3794
C
LEU
A
767
78.954
73.941
98.792
1.00
33.10
6

ATOM
3795
O
LEU
A
767
78.466
74.610
97.886
1.00
32.37
8

ATOM
3796
N
LYS
A
768
78.237
73.423
99.781
1.00
35.38
7

ATOM
3797
CA
LYS
A
768
76.796
73.574
99.841
1.00
37.51
6

ATOM
3798
CB
LYS
A
768
76.270
72.906
101.106
1.00
40.21
6

ATOM
3799
CG
LYS
A
768
74.892
72.316
100.947
1.00
43.48
6

ATOM
3800
CD
LYS
A
768
74.724
71.052
101.782
1.00
45.10
6

ATOM
3801
CE
LYS
A
768
75.717
69.977
101.367
1.00
44.44
6

ATOM
3802
NZ
LYS
A
768
75.363
68.651
101.936
1.00
45.41
7

ATOM
3803
C
LYS
A
768
76.366
75.037
99.772
1.00
39.18
6

ATOM
3804
O
LYS
A
768
75.421
75.375
99.049
1.00
40.00
8

ATOM
3805
N
GLN
A
769
77.069
75.909
100.494
1.00
37.09
7

ATOM
3806
CA
GLN
A
769
76.735
77.330
100.486
1.00
37.20
6

ATOM
3807
CB
GLN
A
769
77.622
78.124
101.465
1.00
38.77
6

ATOM
3808
CG
GLN
A
769
77.606
77.648
102.913
1.00
41.12
6

ATOM
3809
CD
GLN
A
769
78.145
78.700
103.873
1.00
43.44
6

ATOM
3810
OE1
GLN
A
769
79.125
79.379
103.583
1.00
45.95
8

ATOM
3811
NE2
GLN
A
769
77.504
78.830
105.022
1.00
47.56
7

ATOM
3812
C
GLN
A
769
76.916
77.903
99.081
1.00
37.84
6

ATOM
3813
O
GLN
A
769
76.058
78.627
98.582
1.00
34.96
8

ATOM
3814
N
LYS
A
770
78.044
77.583
98.451
1.00
39.41
7

ATOM
3815
CA
LYS
A
770
78.323
78.079
97.108
1.00
41.73
6

ATOM
3816
CB
LYS
A
770
79.698
77.605
96.640
1.00
43.11
6

ATOM
3817
CG
LYS
A
770
80.860
78.220
97.394
1.00
42.84
6

ATOM
3818
CD
LYS
A
770
82.179
77.692
96.862
1.00
43.55
6

ATOM
3819
CE
LYS
A
770
83.361
78.302
97.590
1.00
44.60
6

ATOM
3820
NZ
LYS
A
770
83.419
79.776
97.397
1.00
44.90
7

ATOM
3821
C
LYS
A
770
77.257
77.632
96.110
1.00
42.27
6

ATOM
3822
O
LYS
A
770
76.839
78.412
95.253
1.00
41.85
8

ATOM
3823
N
LEU
A
771
76.818
76.380
96.229
1.00
42.21
7

ATOM
3824
CA
LEU
A
771
75.792
75.847
95.339
1.00
43.45
6

ATOM
3825
CB
LEU
A
771
75.640
74.335
95.537
1.00
40.02
6

ATOM
3826
CG
LEU
A
771
76.824
73.473
95.076
1.00
37.80
6

ATOM
3827
CD1
LEU
A
771
76.514
71.997
95.290
1.00
35.60
6

ATOM
3828
CD2
LEU
A
771
77.103
73.747
93.606
1.00
36.43
6

ATOM
3829
C
LEU
A
771
74.455
76.540
95.581
1.00
46.60
6

ATOM
3830
O
LEU
A
771
73.726
76.850
94.634
1.00
45.26
8

ATOM
3831
N
GLU
A
772
74.134
76.779
96.850
1.00
49.24
7

ATOM
3832
CA
GLU
A
772
72.891
77.450
97.210
1.00
52.60
6

ATOM
3833
CB
GLU
A
772
72.811
77.667
98.724
1.00
54.62
6

ATOM
3834
CG
GLU
A
772
72.402
76.445
99.530
1.00
58.60
6

ATOM
3835
CD
GLU
A
772
70.932
76.087
99.359
1.00
61.85
6

ATOM
3836
OE1
GLU
A
772
70.077
76.979
99.554
1.00
63.98
8

ATOM
3837
OE2
GLU
A
772
70.627
74.915
99.040
1.00
61.89
8

ATOM
3838
C
GLU
A
772
72.813
78.798
96.504
1.00
53.53
6

ATOM
3839
O
GLU
A
772
71.757
79.192
96.015
1.00
54.00
8

ATOM
3840
N
ASN
A
773
73.939
79.499
96.448
1.00
54.36
7

ATOM
3841
CA
ASN
A
773
73.983
80.797
95.800
1.00
57.04
6

ATOM
3842
CB
ASN
A
773
75.333
81.471
96.055
1.00
57.86
6

ATOM
3843
CG
ASN
A
773
75.531
81.842
97.514
1.00
59.86
6

ATOM
3844
OD1
ASN
A
773
76.572
82.373
97.899
1.00
60.74
8

ATOM
3845
ND2
ASN
A
773
74.524
81.562
98.337
1.00
60.42
7

ATOM
3846
C
ASN
A
773
73.716
80.681
94.302
1.00
58.60
6

ATOM
3847
O
ASN
A
773
72.982
81.492
93.736
1.00
58.99
8

ATOM
3848
N
LEU
A
774
74.304
79.672
93.661
1.00
59.50
7

ATOM
3849
CA
LEU
A
774
74.075
79.467
92.228
1.00
60.33
6

ATOM
3850
CB
LEU
A
774
74.965
78.307
91.680
1.00
59.59
6

ATOM
3851
CG
LEU
A
774
76.487
78.451
91.672
1.00
59.52
6

ATOM
3852
CD1
LEU
A
774
77.131
77.286
90.946
1.00
59.18
6

ATOM
3853
CD2
LEU
A
774
76.879
79.765
91.022
1.00
58.36
6

ATOM
3854
C
LEU
A
774
72.615
79.119
91.939
1.00
61.58
6

ATOM
3855
O
LEU
A
774
71.963
79.806
91.145
1.00
62.38
8

ATOM
3856
N
GLN
A
775
72.107
78.047
92.572
1.00
62.93
7

ATOM
3857
CA
GLN
A
775
70.725
77.516
92.437
1.00
64.63
6

ATOM
3858
CB
GLN
A
775
70.333
76.759
93.700
1.00
63.69
6

ATOM
3859
CG
GLN
A
775
69.060
75.960
93.534
1.00
63.39
6

ATOM
3860
CD
GLN
A
775
69.335
74.784
92.627
1.00
63.58
6

ATOM
3861
OE1
GLN
A
775
69.786
74.942
91.496
1.00
63.72
8

ATOM
3862
NE2
GLN
A
775
69.116
73.519
92.924
1.00
63.03
7

ATOM
3863
C
GLN
A
775
69.696
78.595
92.188
1.00
66.62
6

ATOM
3864
O
GLN
A
775
69.249
78.842
91.061
1.00
66.42
8

ATOM
3865
N
ASN
A
776
69.357
79.245
93.291
1.00
69.46
7

ATOM
3866
CA
ASN
A
776
68.421
80.352
93.293
1.00
72.25
6

ATOM
3867
CB
ASN
A
776
68.407
80.901
94.726
1.00
73.02
6

ATOM
3868
CG
ASN
A
776
67.896
79.797
95.666
1.00
74.84
6

ATOM
3869
OD1
ASN
A
776
66.722
79.434
95.605
1.00
75.60
8

ATOM
3870
ND2
ASN
A
776
68.764
79.283
96.514
1.00
75.30
7

ATOM
3871
C
ASN
A
776
68.706
81.302
92.059
1.00
73.56
6

ATOM
3872
O
ASN
A
776
69.831
81.277
91.570
1.00
74.49
8

ATOM
3873
N
SER
A
777
67.748
82.110
91.544
1.00
74.25
7

ATOM
3874
CA
SER
A
777
67.879
82.935
90.273
1.00
74.53
6

ATOM
3875
CB
SER
A
777
66.997
84.179
90.360
1.00
75.23
6

ATOM
3876
OG
SER
A
777
66.780
84.739
89.072
1.00
73.47
8

ATOM
3877
C
SER
A
777
69.256
83.384
89.763
1.00
75.03
6

ATOM
3878
O
SER
A
777
69.609
84.571
89.851
1.00
75.46
8

ATOM
3879
N
GLN
A
778
70.001
82.418
89.244
1.00
75.28
7

ATOM
3880
CA
GLN
A
778
71.310
82.593
88.586
1.00
75.03
6

ATOM
3881
CB
GLN
A
778
72.533
82.780
89.547
1.00
75.82
6

ATOM
3882
CG
GLN
A
778
73.552
83.851
89.057
1.00
77.52
6

ATOM
3883
CD
GLN
A
778
74.962
83.824
89.659
1.00
78.46
6

ATOM
3884
OE1
GLN
A
778
75.891
83.253
89.087
1.00
78.53
8

ATOM
3885
NE2
GLN
A
778
75.335
84.398
90.801
1.00
79.22
7

ATOM
3886
C
GLN
A
778
71.469
81.332
87.747
1.00
73.94
6

ATOM
3887
O
GLN
A
778
71.313
81.338
86.534
1.00
74.20
8

ATOM
3888
N
LEU
A
779
71.785
80.245
88.422
1.00
72.78
7

ATOM
3889
CA
LEU
A
779
71.982
78.947
87.756
1.00
71.39
6

ATOM
3890
CB
LEU
A
779
72.505
77.925
88.730
1.00
72.21
6

ATOM
3891
CG
LEU
A
779
72.665
76.517
88.169
1.00
72.85
6

ATOM
3892
CD1
LEU
A
779
73.683
75.736
88.987
1.00
72.47
6

ATOM
3893
CD2
LEU
A
779
71.314
75.791
88.140
1.00
72.76
6

ATOM
3894
C
LEU
A
779
70.687
78.471
87.110
1.00
69.63
6

ATOM
3895
O
LEU
A
779
69.593
78.657
87.615
1.00
70.11
8

ATOM
3896
N
PRO
A
780
70.890
77.853
85.942
1.00
67.91
7

ATOM
3897
CD
PRO
A
780
71.884
78.390
84.991
1.00
68.03
6

ATOM
3898
CA
PRO
A
780
69.727
77.430
85.114
1.00
65.90
6

ATOM
3899
CB
PRO
A
780
70.385
76.850
83.866
1.00
66.31
6

ATOM
3900
CG
PRO
A
780
71.532
77.770
83.669
1.00
67.63
6

ATOM
3901
C
PRO
A
780
68.672
76.543
85.679
1.00
63.40
6

ATOM
3902
O
PRO
A
780
68.844
75.861
86.677
1.00
64.20
8

ATOM
3903
N
GLU
A
781
67.571
76.592
84.992
1.00
60.69
7

ATOM
3904
CA
GLU
A
781
66.494
75.708
85.309
1.00
58.15
6

ATOM
3905
CB
GLU
A
781
65.159
76.214
84.792
1.00
59.12
6

ATOM
3906
CG
GLU
A
781
64.722
77.532
85.410
1.00
61.94
6

ATOM
3907
CD
GLU
A
781
63.224
77.756
85.363
1.00
64.17
6

ATOM
3908
OE1
GLU
A
781
62.607
77.442
84.321
1.00
65.21
8

ATOM
3909
OE2
GLU
A
781
62.666
78.252
86.364
1.00
64.28
8

ATOM
3910
C
GLU
A
781
66.884
74.383
84.683
1.00
54.42
6

ATOM
3911
O
GLU
A
781
66.543
73.345
85.241
1.00
54.46
8

ATOM
3912
N
SER
A
782
67.576
74.366
83.531
1.00
49.82
7

ATOM
3913
CA
SER
A
782
67.963
73.094
82.935
1.00
45.58
6

ATOM
3914
CB
SER
A
782
66.739
72.385
82.355
1.00
45.52
6

ATOM
3915
OG
SER
A
782
66.098
73.186
81.382
1.00
47.08
8

ATOM
3916
C
SER
A
782
69.036
73.250
81.859
1.00
41.51
6

ATOM
3917
O
SER
A
782
69.379
74.361
81.451
1.00
41.53
8

ATOM
3918
N
PHE
A
783
69.574
72.121
81.417
1.00
37.19
7

ATOM
3919
CA
PHE
A
783
70.614
72.111
80.401
1.00
33.67
6

ATOM
3920
CB
PHE
A
783
71.916
72.694
80.964
1.00
33.31
6

ATOM
3921
CG
PHE
A
783
72.504
71.897
82.106
1.00
34.50
6

ATOM
3922
CD1
PHE
A
783
72.018
72.043
83.403
1.00
35.11
6

ATOM
3923
CD2
PHE
A
783
73.539
70.993
81.880
1.00
34.92
6

ATOM
3924
CE1
PHE
A
783
72.555
71.299
84.464
1.00
35.01
6

ATOM
3925
CE2
PHE
A
783
74.083
70.240
82.935
1.00
35.93
6

ATOM
3926
CZ
PHE
A
783
73.589
70.395
84.225
1.00
34.85
6

ATOM
3927
C
PHE
A
783
70.846
70.671
79.971
1.00
33.09
6

ATOM
3928
O
PHE
A
783
70.482
69.736
80.692
1.00
32.31
8

ATOM
3929
N
ARG
A
784
71.435
70.482
78.792
1.00
31.67
7

ATOM
3930
CA
ARG
A
784
71.718
69.131
78.322
1.00
30.61
6

ATOM
3931
CB
ARG
A
784
71.867
69.076
76.804
1.00
32.75
6

ATOM
3932
CG
ARG
A
784
70.655
69.487
76.028
1.00
36.52
6

ATOM
3933
CD
ARG
A
784
70.864
69.197
74.546
1.00
39.76
6

ATOM
3934
NE
ARG
A
784
69.860
69.873
73.736
1.00
44.36
7

ATOM
3935
CZ
ARG
A
784
68.560
69.867
74.010
1.00
46.66
6

ATOM
3936
NH1
ARG
A
784
68.106
69.215
75.074
1.00
46.34
7

ATOM
3937
NH2
ARG
A
784
67.712
70.529
73.232
1.00
47.21
7

ATOM
3938
C
ARG
A
784
73.025
68.673
78.924
1.00
27.12
6

ATOM
3939
O
ARG
A
784
73.964
69.455
79.058
1.00
26.83
8

ATOM
3940
N
VAL
A
785
73.085
67.402
79.284
1.00
25.48
7

ATOM
3941
CA
VAL
A
785
74.302
66.848
79.845
1.00
24.76
6

ATOM
3942
CB
VAL
A
785
74.028
65.468
80.465
1.00
24.92
6

ATOM
3943
CG1
VAL
A
785
75.315
64.890
81.048
1.00
24.86
6

ATOM
3944
CG2
VAL
A
785
72.953
65.602
81.553
1.00
27.03
6

ATOM
3945
C
VAL
A
785
75.242
66.724
78.645
1.00
23.91
6

ATOM
3946
O
VAL
A
785
74.983
65.941
77.735
1.00
25.78
8

ATOM
3947
N
PRO
A
786
76.374
67.466
78.728
1.00
23.48
7

ATOM
3948
CD
PRO
A
786
76.368
68.800
79.313
1.00
22.61
6

ATOM
3949
CA
PRO
A
786
77.372
67.484
77.593
1.00
23.56
6

ATOM
3950
CB
PRO
A
786
78.486
68.359
78.126
1.00
23.40
6

ATOM
3951
CG
PRO
A
786
77.684
69.404
78.873
1.00
24.69
6

ATOM
3952
C
PRO
A
786
77.771
66.177
76.960
1.00
26.48
6

ATOM
3953
O
PRO
A
786
77.883
66.064
75.740
1.00
27.16
8

ATOM
3954
N
TYR
A
787
77.994
65.164
77.794
1.00
26.51
7

ATOM
3955
CA
TYR
A
787
78.411
63.853
77.319
1.00
27.39
6

ATOM
3956
CB
TYR
A
787
79.350
63.162
78.335
1.00
25.26
6

ATOM
3957
CG
TYR
A
787
78.699
63.034
79.675
1.00
28.23
6

ATOM
3958
CD1
TYR
A
787
77.715
62.087
79.934
1.00
30.67
6

ATOM
3959
CE1
TYR
A
787
77.115
62.001
81.183
1.00
32.43
6

ATOM
3960
CD2
TYR
A
787
79.074
63.896
80.706
1.00
31.75
6

ATOM
3961
CE2
TYR
A
787
78.484
63.817
81.956
1.00
32.50
6

ATOM
3962
CZ
TYR
A
787
77.509
62.872
82.190
1.00
32.90
6

ATOM
3963
OH
TYR
A
787
76.933
62.794
83.433
1.00
33.46
8

ATOM
3964
C
TYR
A
787
77.241
62.929
77.022
1.00
28.59
6

ATOM
3965
O
TYR
A
787
77.412
61.701
76.998
1.00
30.35
8

ATOM
3966
N
ASP
A
788
76.065
63.507
76.813
1.00
30.11
7

ATOM
3967
CA
ASP
A
788
74.856
62.734
76.476
1.00
29.60
6

ATOM
3968
CB
ASP
A
788
74.507
61.716
77.531
1.00
30.20
6

ATOM
3969
CG
ASP
A
788
73.394
60.866
76.988
1.00
32.48
6

ATOM
3970
OD1
ASP
A
788
72.745
61.276
76.004
1.00
32.27
8

ATOM
3971
OD2
ASP
A
788
73.174
59.774
77.541
1.00
32.51
8

ATOM
3972
C
ASP
A
788
73.701
63.676
76.257
1.00
28.89
6

ATOM
3973
O
ASP
A
788
72.934
64.038
77.153
1.00
30.12
8

ATOM
3974
N
PRO
A
789
73.652
64.049
74.998
1.00
27.45
7

ATOM
3975
CD
PRO
A
789
74.921
64.187
74.299
1.00
26.17
6

ATOM
3976
CA
PRO
A
789
72.733
65.078
74.514
1.00
26.76
6

ATOM
3977
CB
PRO
A
789
73.083
65.132
73.048
1.00
25.26
6

ATOM
3978
CG
PRO
A
789
74.573
64.950
73.068
1.00
24.36
6

ATOM
3979
C
PRO
A
789
71.275
64.941
74.895
1.00
27.24
6

ATOM
3980
O
PRO
A
789
70.593
65.905
75.247
1.00
29.34
8

ATOM
3981
N
GLY
A
790
70.826
63.691
74.801
1.00
28.50
7

ATOM
3982
CA
GLY
A
790
69.438
63.339
75.058
1.00
31.00
6

ATOM
3983
C
GLY
A
790
69.013
63.550
76.492
1.00
33.67
6

ATOM
3984
O
GLY
A
790
67.822
63.484
76.841
1.00
33.95
8

ATOM
3985
N
LEU
A
791
69.993
63.824
77.315
1.00
33.18
7

ATOM
3986
CA
LEU
A
791
69.770
63.993
78.744
1.00
33.86
6

ATOM
3987
CB
LEU
A
791
70.904
63.360
79.557
1.00
34.55
6

ATOM
3988
CG
LEU
A
791
70.732
61.926
80.043
1.00
38.86
6

ATOM
3989
CD1
LEU
A
791
71.771
61.603
81.111
1.00
39.50
6

ATOM
3990
CD2
LEU
A
791
69.337
61.699
80.594
1.00
38.23
6

ATOM
3991
C
LEU
A
791
69.620
65.455
79.141
1.00
32.73
6

ATOM
3992
O
LEU
A
791
70.469
66.311
78.864
1.00
29.98
8

ATOM
3993
N
LYS
A
792
68.496
65.732
79.808
1.00
34.39
7

ATOM
3994
CA
LYS
A
792
68.192
67.074
80.325
1.00
35.90
6

ATOM
3995
CB
LYS
A
792
66.824
67.566
79.882
1.00
39.38
6

ATOM
3996
CG
LYS
A
792
66.861
68.638
78.808
1.00
44.79
6

ATOM
3997
CD
LYS
A
792
67.434
69.951
79.316
1.00
48.94
6

ATOM
3998
CE
LYS
A
792
67.228
71.067
78.304
1.00
50.78
6

ATOM
3999
NZ
LYS
A
792
65.779
71.348
78.089
1.00
52.65
7

ATOM
4000
C
LYS
A
792
68.290
67.121
81.873
1.00
35.39
6

ATOM
4001
O
LYS
A
792
67.550
66.431
82.571
1.00
33.43
8

ATOM
4002
N
ALA
A
793
69.211
67.933
82.380
1.00
36.45
7

ATOM
4003
CA
ALA
A
793
69.391
68.075
83.820
1.00
37.53
6

ATOM
4004
CB
ALA
A
793
70.868
68.257
84.150
1.00
37.18
6

ATOM
4005
C
ALA
A
793
68.585
69.263
84.347
1.00
38.45
6

ATOM
4006
O
ALA
A
793
68.537
70.325
83.724
1.00
37.12
8

ATOM
4007
N
GLY
A
794
67.959
69.073
85.505
1.00
40.25
7

ATOM
4008
CA
GLY
A
794
67.171
70.129
86.105
1.00
40.58
6

ATOM
4009
C
GLY
A
794
67.934
70.792
87.228
1.00
41.08
6

ATOM
4010
O
GLY
A
794
69.138
71.044
87.111
1.00
41.92
8

ATOM
4011
N
ALA
A
795
67.240
71.061
88.328
1.00
41.21
7

ATOM
4012
CA
ALA
A
795
67.858
71.703
89.482
1.00
40.04
6

ATOM
4013
CB
ALA
A
795
66.780
72.234
90.425
1.00
40.19
6

ATOM
4014
C
ALA
A
795
68.789
70.767
90.239
1.00
38.81
6

ATOM
4015
O
ALA
A
795
68.648
69.545
90.189
1.00
37.12
8

ATOM
4016
N
LEU
A
796
69.748
71.366
90.935
1.00
37.96
7

ATOM
4017
CA
LEU
A
796
70.708
70.621
91.735
1.00
37.80
6

ATOM
4018
CB
LEU
A
796
71.844
71.541
92.189
1.00
38.03
6

ATOM
4019
CG
LEU
A
796
72.997
71.838
91.236
1.00
37.56
6

ATOM
4020
CD1
LEU
A
796
73.612
73.181
91.574
1.00
36.92
6

ATOM
4021
CD2
LEU
A
796
74.024
70.716
91.337
1.00
37.37
6

ATOM
4022
C
LEU
A
796
70.030
70.052
92.971
1.00
37.40
6

ATOM
4023
O
LEU
A
796
69.133
70.672
93.542
1.00
38.32
8

ATOM
4024
N
ALA
A
797
70.457
68.859
93.364
1.00
36.73
7

ATOM
4025
CA
ALA
A
797
69.953
68.200
94.562
1.00
37.48
6

ATOM
4026
CB
ALA
A
797
69.798
66.710
94.314
1.00
37.45
6

ATOM
4027
C
ALA
A
797
71.090
68.467
95.551
1.00
38.36
6

ATOM
4028
O
ALA
A
797
71.875
67.574
95.877
1.00
36.66
8

ATOM
4029
N
ILE
A
798
71.175
69.718
95.994
1.00
39.34
7

ATOM
4030
CA
ILE
A
798
72.238
70.174
96.884
1.00
40.04
6

ATOM
4031
CB
ILE
A
798
71.979
71.637
97.334
1.00
39.14
6

ATOM
4032
CG2
ILE
A
798
73.177
72.175
98.128
1.00
39.45
6

ATOM
4033
CG1
ILE
A
798
71.777
72.515
96.092
1.00
37.29
6

ATOM
4034
CD1
ILE
A
798
71.679
73.999
96.375
1.00
34.88
6

ATOM
4035
C
ILE
A
798
72.523
69.296
98.094
1.00
41.31
6

ATOM
4036
O
ILE
A
798
73.678
69.174
98.511
1.00
41.00
8

ATOM
4037
N
GLU
A
799
71.485
68.672
98.641
1.00
42.02
7

ATOM
4038
CA
GLU
A
799
71.645
67.807
99.801
1.00
44.18
6

ATOM
4039
CB
GLU
A
799
70.282
67.382
100.360
1.00
46.93
6

ATOM
4040
CG
GLU
A
799
69.399
68.535
100.827
1.00
51.61
6

ATOM
4041
CD
GLU
A
799
68.595
69.164
99.697
1.00
53.73
6

ATOM
4042
OE1
GLU
A
799
69.202
69.696
98.742
1.00
53.92
8

ATOM
4043
OE2
GLU
A
799
67.346
69.125
99.769
1.00
55.13
8

ATOM
4044
C
GLU
A
799
72.443
66.568
99.447
1.00
43.69
6

ATOM
4045
O
GLU
A
799
73.007
65.920
100.321
1.00
45.36
8

ATOM
4046
N
LYS
A
800
72.459
66.111
98.192
1.00
42.80
7

ATOM
4047
CA
LYS
A
800
73.163
64.838
97.811
1.00
41.11
6

ATOM
4048
CB
LYS
A
800
72.372
64.094
96.743
1.00
43.81
6

ATOM
4049
CG
LYS
A
800
71.182
63.348
97.269
1.00
47.82
6

ATOM
4050
CD
LYS
A
800
70.634
62.423
96.204
1.00
52.02
6

ATOM
4051
CE
LYS
A
800
70.188
61.100
96.792
1.00
54.37
6

ATOM
4052
NZ
LYS
A
800
69.394
60.294
95.823
1.00
57.39
7

ATOM
4053
C
LYS
A
800
74.535
65.079
97.243
1.00
38.66
6

ATOM
4054
O
LYS
A
800
75.268
64.150
96.919
1.00
38.72
8

ATOM
4055
N
CYS
A
801
74.854
66.357
97.121
1.00
36.79
7

ATOM
4056
CA
CYS
A
801
76.123
66.707
96.569
1.00
35.93
6

ATOM
4057
CB
CYS
A
801
75.993
67.975
95.728
1.00
33.45
6

ATOM
4058
SG
CYS
A
801
74.821
67.842
94.342
1.00
34.86
16

ATOM
4059
C
CYS
A
801
77.179
66.815
97.670
1.00
36.63
6

ATOM
4060
O
CYS
A
801
76.858
66.924
98.853
1.00
39.22
8

ATOM
4061
N
LYS
A
802
78.471
66.755
97.253
1.00
35.63
7

ATOM
4062
CA
LYS
A
802
79.614
66.779
98.170
1.00
36.28
6

ATOM
4063
CB
LYS
A
802
79.586
65.543
99.090
1.00
36.89
6

ATOM
4064
CG
LYS
A
802
80.133
64.255
98.448
1.00
39.74
6

ATOM
4065
CD
LYS
A
802
79.405
62.998
98.909
1.00
44.19
6

ATOM
4066
CE
LYS
A
802
79.888
61.768
98.160
1.00
46.18
6

ATOM
4067
NZ
LYS
A
802
79.331
60.506
98.736
1.00
46.54
7

ATOM
4068
C
LYS
A
802
80.918
66.820
97.378
1.00
34.53
6

ATOM
4069
O
LYS
A
802
80.932
66.485
96.192
1.00
33.26
8

ATOM
4070
N
VAL
A
803
82.031
67.242
98.040
1.00
59.31
7

ATOM
4071
CA
VAL
A
803
83.372
67.314
97.438
1.00
59.52
6

ATOM
4072
CB
VAL
A
803
84.308
68.307
98.169
1.00
61.03
6

ATOM
4073
CG1
VAL
A
803
85.747
68.133
97.696
1.00
59.47
6

ATOM
4074
CG2
VAL
A
803
83.830
69.738
97.964
1.00
60.86
6

ATOM
4075
C
VAL
A
803
84.036
65.982
97.465
1.00
60.95
6

ATOM
4076
O
VAL
A
803
84.589
65.578
98.488
1.00
61.46
8

ATOM
4077
N
MET
A
804
83.969
65.279
96.356
1.00
102.79
7

ATOM
4078
CA
MET
A
804
84.606
64.017
96.404
1.00
104.12
6

ATOM
4079
CB
MET
A
804
85.170
63.599
95.034
1.00
67.22
6

ATOM
4080
CG
MET
A
804
84.097
63.207
94.020
1.00
68.55
6

ATOM
4081
SD
MET
A
804
84.313
61.513
93.426
1.00
68.12
16

ATOM
4082
CE
MET
A
804
85.720
61.725
92.339
1.00
71.38
6

ATOM
4083
C
MET
A
804
85.664
64.132
97.445
1.00
105.88
6

ATOM
4084
O
MET
A
804
86.039
65.214
97.879
1.00
105.81
8

ATOM
4085
N
ALA
A
805
86.130
62.989
97.837
1.00
114.21
7

ATOM
4086
CA
ALA
A
805
87.218
62.901
98.782
1.00
118.20
6

ATOM
4087
CB
ALA
A
805
86.803
62.152
100.042
1.00
88.92
6

ATOM
4088
C
ALA
A
805
88.337
62.205
98.098
1.00
119.89
6

ATOM
4089
O
ALA
A
805
88.345
60.971
97.973
1.00
120.97
8

ATOM
4090
N
SER
A
806
89.304
62.979
97.671
1.00
114.78
7

ATOM
4091
CA
SER
A
806
90.412
62.424
96.945
1.00
116.27
6

ATOM
4092
CB
SER
A
806
90.002
62.144
95.489
1.00
108.86
6

ATOM
4093
OG
SER
A
806
90.881
61.217
94.883
1.00
112.13
8

ATOM
4094
C
SER
A
806
91.580
63.395
96.971
1.00
115.79
6

ATOM
4095
O
SER
A
806
91.622
64.278
97.824
1.00
115.90
8

ATOM
4096
N
LYS
A
807
92.513
63.217
96.048
1.00
71.87
7

ATOM
4097
CA
LYS
A
807
93.728
64.037
95.982
1.00
72.71
6

ATOM
4098
CB
LYS
A
807
94.781
63.269
95.178
1.00
99.86
6

ATOM
4099
CG
LYS
A
807
95.066
61.866
95.711
1.00
102.72
6

ATOM
4100
CD
LYS
A
807
93.876
60.904
95.526
1.00
104.34
6

ATOM
4101
CE
LYS
A
807
94.047
59.539
96.203
1.00
104.39
6

ATOM
4102
NZ
LYS
A
807
92.847
58.671
96.023
1.00
106.17
7

ATOM
4103
C
LYS
A
807
93.468
65.456
95.469
1.00
71.07
6

ATOM
4104
O
LYS
A
807
94.037
66.440
95.962
1.00
70.57
8

ATOM
4105
N
LYS
A
808
92.594
65.565
94.467
1.00
107.91
7

ATOM
4106
CA
LYS
A
808
92.144
66.856
93.999
1.00
107.44
6

ATOM
4107
CB
LYS
A
808
92.372
67.103
92.522
1.00
138.65
6

ATOM
4108
CG
LYS
A
808
92.914
65.900
91.799
1.00
139.70
6

ATOM
4109
CD
LYS
A
808
93.037
66.170
90.307
1.00
139.32
6

ATOM
4110
CE
LYS
A
808
91.734
65.892
89.558
1.00
141.19
6

ATOM
4111
NZ
LYS
A
808
91.398
66.974
88.595
1.00
143.43
7

ATOM
4112
C
LYS
A
808
90.693
66.898
94.315
1.00
106.49
6

ATOM
4113
O
LYS
A
808
90.055
65.844
94.452
1.00
109.13
8

ATOM
4114
N
LYS
A
809
90.142
68.058
94.430
1.00
46.06
7

ATOM
4115
CA
LYS
A
809
88.840
67.977
94.944
1.00
41.76
6

ATOM
4116
CB
LYS
A
809
88.665
69.122
95.926
1.00
43.79
6

ATOM
4117
CG
LYS
A
809
89.635
69.048
97.122
1.00
45.62
6

ATOM
4118
CD
LYS
A
809
89.829
67.637
97.680
1.00
47.29
6

ATOM
4119
CE
LYS
A
809
90.771
67.621
98.886
1.00
50.46
6

ATOM
4120
NZ
LYS
A
809
90.626
66.382
99.697
1.00
52.09
7

ATOM
4121
C
LYS
A
809
87.704
67.801
93.968
1.00
37.60
6

ATOM
4122
O
LYS
A
809
87.214
68.739
93.326
1.00
36.33
8

ATOM
4123
N
PRO
A
810
87.298
66.548
93.896
1.00
34.24
7

ATOM
4124
CD
PRO
A
810
88.214
65.407
93.633
1.00
33.52
6

ATOM
4125
CA
PRO
A
810
86.108
66.312
93.134
1.00
32.27
6

ATOM
4126
CB
PRO
A
810
85.893
64.801
93.259
1.00
31.33
6

ATOM
4127
CG
PRO
A
810
87.299
64.293
93.194
1.00
32.35
6

ATOM
4128
C
PRO
A
810
84.991
67.195
93.560
1.00
29.93
6

ATOM
4129
O
PRO
A
810
85.064
67.974
94.505
1.00
27.91
8

ATOM
4130
N
LEU
A
811
83.965
67.054
92.822
1.00
27.11
7

ATOM
4131
CA
LEU
A
811
82.721
67.633
93.164
1.00
26.51
6

ATOM
4132
CB
LEU
A
811
82.398
68.953
92.429
1.00
26.29
6

ATOM
4133
CG
LEU
A
811
83.029
70.240
92.960
1.00
27.80
6

ATOM
4134
CD1
LEU
A
811
82.023
71.364
92.947
1.00
24.33
6

ATOM
4135
CD2
LEU
A
811
83.586
70.035
94.360
1.00
28.64
6

ATOM
4136
C
LEU
A
811
81.813
66.550
92.718
1.00
27.39
6

ATOM
4137
O
LEU
A
811
81.826
66.173
91.550
1.00
27.53
8

ATOM
4138
N
TRP
A
812
81.036
66.038
93.609
1.00
26.76
7

ATOM
4139
CA
TRP
A
812
80.081
65.028
93.251
1.00
28.47
6

ATOM
4140
CB
TRP
A
812
80.135
63.885
94.239
1.00
27.76
6

ATOM
4141
CG
TRP
A
812
79.083
62.831
94.199
1.00
28.02
6

ATOM
4142
CD2
TRP
A
812
79.290
61.440
93.924
1.00
26.96
6

ATOM
4143
CE2
TRP
A
812
78.040
60.801
94.041
1.00
27.44
6

ATOM
4144
CE3
TRP
A
812
80.418
60.671
93.590
1.00
30.52
6

ATOM
4145
CD1
TRP
A
812
77.750
62.977
94.453
1.00
27.21
6

ATOM
4146
NE1
TRP
A
812
77.117
61.760
94.367
1.00
29.41
7

ATOM
4147
CZ2
TRP
A
812
77.877
59.420
93.837
1.00
29.36
6

ATOM
4148
CZ3
TRP
A
812
80.257
59.295
93.387
1.00
29.09
6

ATOM
4149
CH2
TRP
A
812
78.994
58.687
93.512
1.00
28.23
6

ATOM
4150
C
TRP
A
812
78.741
65.741
93.268
1.00
31.95
6

ATOM
4151
O
TRP
A
812
78.151
65.968
94.338
1.00
33.57
8

ATOM
4152
N
LEU
A
813
78.255
66.088
92.077
1.00
29.34
7

ATOM
4153
CA
LEU
A
813
77.017
66.836
91.933
1.00
29.69
6

ATOM
4154
CB
LEU
A
813
77.215
68.005
90.961
1.00
27.65
6

ATOM
4155
CG
LEU
A
813
78.391
68.943
91.241
1.00
29.50
6

ATOM
4156
CD1
LEU
A
813
78.437
70.025
90.177
1.00
25.59
6

ATOM
4157
CD2
LEU
A
813
78.255
69.553
92.627
1.00
25.28
6

ATOM
4158
C
LEU
A
813
75.880
65.979
91.429
1.00
30.08
6

ATOM
4159
O
LEU
A
813
76.073
65.088
90.602
1.00
28.54
8

ATOM
4160
N
GLU
A
814
74.690
66.242
91.945
1.00
30.50
7

ATOM
4161
CA
GLU
A
814
73.521
65.500
91.514
1.00
31.58
6

ATOM
4162
CB
GLU
A
814
73.052
64.556
92.616
1.00
33.32
6

ATOM
4163
CG
GLU
A
814
73.879
63.279
92.685
1.00
37.75
6

ATOM
4164
CD
GLU
A
814
73.422
62.334
93.780
1.00
40.58
6

ATOM
4165
OE1
GLU
A
814
72.199
62.224
94.003
1.00
43.36
8

ATOM
4166
OE2
GLU
A
814
74.284
61.688
94.407
1.00
41.51
8

ATOM
4167
C
GLU
A
814
72.414
66.454
91.117
1.00
31.76
6

ATOM
4168
O
GLU
A
814
72.136
67.430
91.820
1.00
29.86
8

ATOM
4169
N
PHE
A
815
71.801
66.180
89.969
1.00
32.36
7

ATOM
4170
CA
PHE
A
815
70.715
67.007
89.461
1.00
31.93
6

ATOM
4171
CB
PHE
A
815
71.072
67.637
88.101
1.00
31.03
6

ATOM
4172
CG
PHE
A
815
72.403
68.341
88.068
1.00
31.37
6

ATOM
4173
CD1
PHE
A
815
73.592
67.616
88.013
1.00
30.17
6

ATOM
4174
CD2
PHE
A
815
72.466
69.732
88.064
1.00
29.19
6

ATOM
4175
CE1
PHE
A
815
74.827
68.266
87.951
1.00
27.77
6

ATOM
4176
CE2
PHE
A
815
73.695
70.387
88.002
1.00
29.22
6

ATOM
4177
CZ
PHE
A
815
74.878
69.647
87.944
1.00
27.08
6

ATOM
4178
C
PHE
A
815
69.478
66.141
89.268
1.00
33.40
6

ATOM
4179
O
PHE
A
815
69.574
64.930
89.043
1.00
33.14
8

ATOM
4180
N
LYS
A
816
68.311
66.761
89.368
1.00
36.21
7

ATOM
4181
CA
LYS
A
816
67.064
66.044
89.142
1.00
38.94
6

ATOM
4182
CB
LYS
A
816
65.889
66.791
89.784
1.00
42.45
6

ATOM
4183
CG
LYS
A
816
66.055
67.122
91.268
1.00
47.51
6

ATOM
4184
CD
LYS
A
816
64.747
67.664
91.843
1.00
50.66
6

ATOM
4185
CE
LYS
A
816
64.893
68.133
93.283
1.00
50.91
6

ATOM
4186
NZ
LYS
A
816
65.793
69.320
93.391
1.00
53.90
7

ATOM
4187
C
LYS
A
816
66.910
66.058
87.617
1.00
38.78
6

ATOM
4188
O
LYS
A
816
67.462
66.938
86.954
1.00
37.41
8

ATOM
4189
N
CYS
A
817
66.183
65.093
87.058
1.00
40.01
7

ATOM
4190
CA
CYS
A
817
65.982
65.055
85.606
1.00
41.19
6

ATOM
4191
CB
CYS
A
817
65.569
63.649
85.141
1.00
41.55
6

ATOM
4192
SG
CYS
A
817
65.320
63.481
83.331
1.00
48.24
16

ATOM
4193
C
CYS
A
817
64.891
66.061
85.259
1.00
40.39
6

ATOM
4194
O
CYS
A
817
63.835
66.071
85.875
1.00
41.00
8

ATOM
4195
N
ALA
A
818
65.147
66.904
84.269
1.00
41.12
7

ATOM
4196
CA
ALA
A
818
64.181
67.920
83.872
1.00
42.28
6

ATOM
4197
CB
ALA
A
818
64.899
69.075
83.179
1.00
40.20
6

ATOM
4198
C
ALA
A
818
63.055
67.405
82.978
1.00
43.10
6

ATOM
4199
O
ALA
A
818
62.313
68.201
82.405
1.00
44.37
8

ATOM
4200
N
ASP
A
819
62.890
66.087
82.855
1.00
44.35
7

ATOM
4201
CA
ASP
A
819
61.833
65.558
82.011
1.00
46.07
6

ATOM
4202
CB
ASP
A
819
62.430
64.671
80.912
1.00
47.24
6

ATOM
4203
CG
ASP
A
819
61.463
64.338
79.795
1.00
50.39
6

ATOM
4204
OD1
ASP
A
819
60.275
64.120
80.097
1.00
50.62
8

ATOM
4205
OD2
ASP
A
819
61.901
64.309
78.614
1.00
50.13
8

ATOM
4206
C
ASP
A
819
60.760
64.771
82.816
1.00
46.48
6

ATOM
4207
O
ASP
A
819
61.070
63.812
83.515
1.00
46.17
8

ATOM
4208
N
PRO
A
820
59.499
65.221
82.708
1.00
48.60
7

ATOM
4209
CD
PRO
A
820
59.244
66.633
82.913
1.00
49.48
6

ATOM
4210
CA
PRO
A
820
58.364
64.516
83.398
1.00
49.59
6

ATOM
4211
CB
PRO
A
820
57.159
65.341
83.062
1.00
48.89
6

ATOM
4212
CG
PRO
A
820
57.749
66.705
83.135
1.00
49.30
6

ATOM
4213
C
PRO
A
820
58.229
63.087
83.063
1.00
50.35
6

ATOM
4214
O
PRO
A
820
58.113
62.181
83.897
1.00
50.89
8

ATOM
4215
N
THR
A
821
58.247
62.922
81.751
1.00
50.45
7

ATOM
4216
CA
THR
A
821
58.076
61.671
81.125
1.00
50.10
6

ATOM
4217
CB
THR
A
821
58.032
61.891
79.617
1.00
51.30
6

ATOM
4218
OG1
THR
A
821
59.348
62.250
79.158
1.00
48.74
8

ATOM
4219
CG2
THR
A
821
57.046
62.998
79.273
1.00
50.18
6

ATOM
4220
C
THR
A
821
59.118
60.646
81.499
1.00
50.66
6

ATOM
4221
O
THR
A
821
58.993
59.461
81.160
1.00
49.58
8

ATOM
4222
N
ALA
A
822
60.153
61.085
82.218
1.00
51.42
7

ATOM
4223
CA
ALA
A
822
61.191
60.176
62.657
1.00
53.36
6

ATOM
4224
CB
ALA
A
822
62.120
60.841
63.666
1.00
53.59
6

ATOM
4225
C
ALA
A
822
60.552
58.924
83.270
1.00
54.99
6

ATOM
4226
O
ALA
A
822
59.474
58.984
83.882
1.00
55.32
8

ATOM
4227
N
LEU
A
823
61.228
57.811
83.086
1.00
57.90
7

ATOM
4228
CA
LEU
A
823
60.721
56.572
83.585
1.00
61.04
6

ATOM
4229
CB
LEU
A
823
61.221
55.472
82.687
1.00
62.72
6

ATOM
4230
CG
LEU
A
823
60.366
54.227
82.728
1.00
64.75
6

ATOM
4231
CD1
LEU
A
823
58.946
54.544
82.289
1.00
66.14
6

ATOM
4232
CD2
LEU
A
823
60.959
53.129
81.847
1.00
65.73
6

ATOM
4233
C
LEU
A
823
61.121
56.287
85.041
1.00
62.70
6

ATOM
4234
O
LEU
A
823
60.826
55.202
85.555
1.00
63.01
8

ATOM
4235
N
SER
A
824
61.817
57.236
85.718
1.00
63.27
7

ATOM
4236
CA
SER
A
824
62.339
57.082
87.102
1.00
63.57
6

ATOM
4237
CB
SER
A
824
63.710
56.395
87.082
1.00
63.48
6

ATOM
4238
OG
SER
A
824
64.219
56.222
88.385
1.00
63.75
8

ATOM
4239
C
SER
A
824
62.454
58.397
87.901
1.00
63.74
6

ATOM
4240
O
SER
A
824
61.989
59.447
87.458
1.00
63.75
8

ATOM
4241
N
ASN
A
825
63.077
58.317
89.070
1.00
64.17
7

ATOM
4242
CA
ASN
A
825
63.274
59.475
89.924
1.00
63.55
6

ATOM
4243
CB
ASN
A
825
62.623
59.224
91.285
1.00
65.66
6

ATOM
4244
CG
ASN
A
825
61.150
58.885
91.169
1.00
67.25
6

ATOM
4245
OD1
ASN
A
825
60.318
59.756
90.907
1.00
69.18
8

ATOM
4246
ND2
ASN
A
825
60.821
57.610
91.348
1.00
67.62
7

ATOM
4247
C
ASN
A
825
64.774
59.676
90.080
1.00
62.15
6

ATOM
4248
O
ASN
A
825
65.225
60.616
90.740
1.00
62.20
8

ATOM
4249
N
GLU
A
826
65.539
58.779
89.459
1.00
59.99
7

ATOM
4250
CA
GLU
A
826
66.995
58.833
89.497
1.00
57.32
6

ATOM
4251
CB
GLU
A
826
67.596
57.854
88.490
1.00
58.57
6

ATOM
4252
CG
GLU
A
826
67.419
56.394
88.819
1.00
62.13
6

ATOM
4253
CD
GLU
A
826
68.044
55.493
87.765
1.00
64.47
6

ATOM
4254
OE1
GLU
A
826
68.054
54.258
87.965
1.00
65.40
8

ATOM
4255
OE2
GLU
A
826
68.521
56.021
86.734
1.00
65.47
8

ATOM
4256
C
GLU
A
826
67.511
60.227
89.163
1.00
54.68
6

ATOM
4257
O
GLU
A
826
67.023
60.876
88.237
1.00
53.65
8

ATOM
4258
N
THR
A
827
68.499
60.686
89.922
1.00
51.47
7

ATOM
4259
CA
THR
A
827
69.082
61.989
89.660
1.00
48.17
6

ATOM
4260
CB
THR
A
827
69.636
62.659
90.938
1.00
49.20
6

ATOM
4261
OG1
THR
A
827
70.558
61.771
91.581
1.00
50.25
8

ATOM
4262
CG2
THR
A
827
68.506
63.018
91.892
1.00
50.74
6

ATOM
4263
C
THR
A
827
70.240
61.770
88.702
1.00
44.57
6

ATOM
4264
O
THR
A
827
70.752
60.659
88.570
1.00
43.13
8

ATOM
4265
N
ILE
A
828
70.642
62.833
88.025
1.00
39.70
7

ATOM
4266
CA
ILE
A
828
71.751
62.749
87.099
1.00
35.22
6

ATOM
4267
CB
ILE
A
828
71.555
63.725
85.936
1.00
34.44
6

ATOM
4268
CG2
ILE
A
828
72.747
63.653
84.983
1.00
32.18
6

ATOM
4269
CG1
ILE
A
828
70.239
63.386
85.221
1.00
33.81
6

ATOM
4270
CD1
ILE
A
828
69.774
64.435
84.250
1.00
33.61
6

ATOM
4271
C
ILE
A
828
73.004
63.110
87.880
1.00
32.07
6

ATOM
4272
O
ILE
A
828
73.101
64.199
88.440
1.00
30.62
8

ATOM
4273
N
GLY
A
829
73.950
62.181
87.927
1.00
30.08
7

ATOM
4274
CA
GLY
A
829
75.180
62.416
88.650
1.00
30.32
6

ATOM
4275
C
GLY
A
829
76.315
62.838
87.747
1.00
30.04
6

ATOM
4276
O
GLY
A
829
76.572
62.219
86.714
1.00
30.92
8

ATOM
4277
N
ILE
A
830
76.994
63.906
88.141
1.00
28.55
7

ATOM
4278
CA
ILE
A
830
78.115
64.425
87.386
1.00
28.08
6

ATOM
4279
CB
ILE
A
830
77.747
65.685
86.597
1.00
28.19
6

ATOM
4280
CG2
ILE
A
830
78.972
66.182
85.851
1.00
28.86
6

ATOM
4281
CG1
ILE
A
830
76.578
65.403
85.650
1.00
27.05
6

ATOM
4282
CD1
ILE
A
830
76.118
66.638
84.884
1.00
27.96
6

ATOM
4283
C
ILE
A
830
79.230
64.806
88.338
1.00
28.63
6

ATOM
4284
O
ILE
A
830
78.993
65.467
89.356
1.00
26.85
8

ATOM
4285
N
ILE
A
831
80.441
64.378
87.999
1.00
26.21
7

ATOM
4286
CA
ILE
A
831
81.615
64.679
88.785
1.00
26.38
6

ATOM
4287
CB
ILE
A
831
82.558
63.457
88.913
1.00
26.98
6

ATOM
4288
CG2
ILE
A
831
83.956
63.889
89.361
1.00
26.06
6

ATOM
4289
CG1
ILE
A
831
81.976
62.421
89.877
1.00
27.70
6

ATOM
4290
CD1
ILE
A
831
82.790
61.153
89.977
1.00
26.98
6

ATOM
4291
C
ILE
A
831
82.402
65.769
88.116
1.00
27.70
6

ATOM
4292
O
ILE
A
831
82.733
65.669
86.936
1.00
28.99
8

ATOM
4293
N
PHE
A
832
82.693
66.816
88.866
1.00
27.17
7

ATOM
4294
CA
PHE
A
832
83.471
67.925
88.321
1.00
26.96
6

ATOM
4295
CB
PHE
A
832
82.826
69.275
88.587
1.00
30.60
6

ATOM
4296
CG
PHE
A
832
82.323
69.917
87.293
1.00
32.02
6

ATOM
4297
CD1
PHE
A
832
81.036
69.643
86.854
1.00
35.35
6

ATOM
4298
CD2
PHE
A
832
83.132
70.754
86.535
1.00
35.30
6

ATOM
4299
CE1
PHE
A
832
80.556
70.195
85.670
1.00
38.23
6

ATOM
4300
CE2
PHE
A
832
82.666
71.313
85.346
1.00
37.43
6

ATOM
4301
CZ
PHE
A
832
81.378
71.033
84.915
1.00
37.52
6

ATOM
4302
C
PHE
A
832
84.894
67.835
88.838
1.00
29.18
6

ATOM
4303
O
PHE
A
832
85.147
67.866
90.042
1.00
27.37
8

ATOM
4304
N
LYS
A
833
85.835
67.728
87.907
1.00
28.65
7

ATOM
4305
CA
LYS
A
833
87.203
67.520
88.326
1.00
30.32
6

ATOM
4306
CB
LYS
A
833
87.519
66.037
88.105
1.00
29.20
6

ATOM
4307
CG
LYS
A
833
89.000
65.711
88.174
1.00
29.35
6

ATOM
4308
CD
LYS
A
833
89.244
64.206
88.286
1.00
32.24
6

ATOM
4309
CE
LYS
A
833
88.859
63.495
87.004
1.00
35.61
6

ATOM
4310
NZ
LYS
A
833
88.954
62.010
87.135
1.00
39.32
7

ATOM
4311
C
LYS
A
833
88.299
68.408
87.706
1.00
30.09
6

ATOM
4312
O
LYS
A
833
88.294
68.753
86.523
1.00
27.79
8

ATOM
4313
N
HIS
A
834
89.243
68.739
88.617
1.00
29.77
7

ATOM
4314
CA
HIS
A
834
90.469
69.537
88.384
1.00
29.14
6

ATOM
4315
CB
HIS
A
834
90.437
70.915
89.075
1.00
31.68
6

ATOM
4316
CG
HIS
A
834
91.815
71.616
88.954
1.00
35.07
6

ATOM
4317
CD2
HIS
A
834
92.932
71.588
89.753
1.00
36.22
6

ATOM
4318
ND1
HIS
A
834
92.126
72.422
87.889
1.00
38.17
7

ATOM
4319
CE1
HIS
A
834
93.376
72.869
88.016
1.00
38.63
6

ATOM
4320
NE2
HIS
A
834
93.888
72.364
89.138
1.00
37.08
7

ATOM
4321
C
HIS
A
834
91.680
68.767
88.920
1.00
30.26
6

ATOM
4322
O
HIS
A
834
91.635
68.215
90.017
1.00
30.74
8

ATOM
4323
N
GLY
A
835
92.749
68.734
88.160
1.00
30.76
7

ATOM
4324
CA
GLY
A
835
93.941
68.032
88.579
1.00
32.62
6

ATOM
4325
C
GLY
A
835
94.338
66.964
87.576
1.00
33.45
6

ATOM
4326
O
GLY
A
835
95.495
66.549
87.501
1.00
34.55
8

ATOM
4327
N
ASP
A
836
93.378
66.527
86.799
1.00
33.08
7

ATOM
4328
CA
ASP
A
836
93.579
65.500
85.784
1.00
31.14
6

ATOM
4329
CB
ASP
A
836
92.609
64.349
85.961
1.00
33.88
6

ATOM
4330
CG
ASP
A
836
93.048
63.327
86.977
1.00
37.89
6

ATOM
4331
OD1
ASP
A
836
93.706
63.710
87.955
1.00
38.81
8

ATOM
4332
OD2
ASP
A
836
92.742
62.128
86.793
1.00
38.90
8

ATOM
4333
C
ASP
A
836
93.291
66.085
84.447
1.00
28.79
6

ATOM
4334
O
ASP
A
836
92.237
66.670
84.237
1.00
27.78
8

ATOM
4335
N
ASP
A
837
94.197
65.956
83.524
1.00
29.31
7

ATOM
4336
CA
ASP
A
837
93.875
66.451
82.199
1.00
29.32
6

ATOM
4337
CB
ASP
A
837
95.076
66.585
81.293
1.00
30.00
6

ATOM
4338
CG
ASP
A
837
94.639
66.703
79.857
1.00
31.07
6

ATOM
4339
OD1
ASP
A
837
93.446
66.479
79.575
1.00
28.53
8

ATOM
4340
OD2
ASP
A
837
95.498
67.029
79.005
1.00
32.80
8

ATOM
4341
C
ASP
A
837
92.928
65.446
81.631
1.00
28.57
6

ATOM
4342
O
ASP
A
837
93.243
64.272
81.543
1.00
29.74
8

ATOM
4343
N
LEU
A
838
91.799
65.899
81.263
1.00
25.47
7

ATOM
4344
CA
LEU
A
838
90.845
64.926
80.831
1.00
26.83
6

ATOM
4345
CB
LEU
A
838
89.461
65.382
81.274
1.00
24.11
6

ATOM
4346
CG
LEU
A
838
88.917
64.823
82.594
1.00
29.24
6

ATOM
4347
CD1
LEU
A
838
90.035
64.152
83.390
1.00
31.09
6

ATOM
4348
CD2
LEU
A
838
88.259
65.933
83.404
1.00
27.44
6

ATOM
4349
C
LEU
A
838
90.853
64.640
79.353
1.00
23.12
6

ATOM
4350
O
LEU
A
838
90.045
63.827
78.869
1.00
20.45
8

ATOM
4351
N
ARG
A
839
91.750
65.291
78.617
1.00
23.63
7

ATOM
4352
CA
ARG
A
839
91.837
65.081
77.169
1.00
25.47
6

ATOM
4353
CB
ARG
A
839
92.722
66.137
76.511
1.00
26.36
6

ATOM
4354
CG
ARG
A
839
92.114
67.525
76.570
1.00
30.91
6

ATOM
4355
CD
ARG
A
839
92.842
68.488
75.666
1.00
34.49
6

ATOM
4356
NE
ARG
A
839
94.173
68.001
75.323
1.00
38.70
7

ATOM
4357
CZ
ARG
A
839
95.060
68.696
74.618
1.00
41.12
6

ATOM
4358
NH1
ARG
A
839
94.753
69.913
74.179
1.00
42.88
7

ATOM
4359
NH2
ARG
A
839
96.253
68.179
74.360
1.00
41.59
7

ATOM
4360
C
ARG
A
839
92.338
63.682
76.875
1.00
24.92
6

ATOM
4361
O
ARG
A
839
92.048
63.090
75.837
1.00
23.84
8

ATOM
4362
N
GLN
A
840
93.114
63.164
77.819
1.00
25.10
7

ATOM
4363
CA
GLN
A
840
93.694
61.842
77.693
1.00
26.20
6

ATOM
4364
CB
GLN
A
840
94.846
61.649
78.689
1.00
29.04
6

ATOM
4365
CG
GLN
A
840
95.997
62.619
78.472
1.00
35.48
6

ATOM
4366
CD
GLN
A
840
97.142
62.388
79.431
1.00
39.77
6

ATOM
4367
OE1
GLN
A
840
97.552
61.259
79.667
1.00
44.25
8

ATOM
4368
NE2
GLN
A
840
97.810
63.309
80.094
1.00
42.92
7

ATOM
4369
C
GLN
A
840
92.604
60.808
77.911
1.00
24.56
6

ATOM
4370
O
GLN
A
840
92.501
59.821
77.170
1.00
25.02
8

ATOM
4371
N
ASP
A
841
91.783
61.041
78.929
1.00
23.42
7

ATOM
4372
CA
ASP
A
841
90.677
60.150
79.223
1.00
23.09
6

ATOM
4373
CB
ASP
A
841
89.941
60.626
80.481
1.00
25.45
6

ATOM
4374
CG
ASP
A
841
90.538
60.045
81.780
1.00
30.39
6

ATOM
4375
OD1
ASP
A
841
91.717
60.340
82.099
1.00
31.69
8

ATOM
4376
OD2
ASP
A
841
89.824
59.293
82.476
1.00
30.95
8

ATOM
4377
C
ASP
A
841
89.720
60.126
78.014
1.00
22.44
6

ATOM
4378
O
ASP
A
841
89.209
59.072
77.637
1.00
20.36
8

ATOM
4379
N
MET
A
842
89.472
61.283
77.407
1.00
20.01
7

ATOM
4380
CA
MET
A
842
88.575
61.318
76.249
1.00
21.15
6

ATOM
4381
CB
MET
A
842
88.410
62.741
75.720
1.00
21.76
6

ATOM
4382
CG
MET
A
842
87.710
63.681
76.681
1.00
25.39
6

ATOM
4383
SD
MET
A
842
87.407
65.307
75.949
1.00
29.43
16

ATOM
4384
CE
MET
A
842
88.996
65.658
75.209
1.00
28.32
6

ATOM
4385
C
MET
A
842
89.098
60.424
75.126
1.00
21.60
6

ATOM
4386
O
MET
A
842
88.331
59.684
74.516
1.00
23.11
8

ATOM
4387
N
LEU
A
843
90.404
60.494
74.881
1.00
20.78
7

ATOM
4388
CA
LEU
A
843
91.048
59.704
73.843
1.00
21.23
6

ATOM
4389
CB
LEU
A
843
92.516
60.114
73.694
1.00
21.07
6

ATOM
4390
CG
LEU
A
843
92.916
61.142
72.612
1.00
26.77
6

ATOM
4391
CD1
LEU
A
843
91.671
61.713
71.933
1.00
24.36
6

ATOM
4392
CD2
LEU
A
843
93.752
62.251
73.210
1.00
23.36
6

ATOM
4393
C
LEU
A
843
90.942
58.215
74.127
1.00
21.17
6

ATOM
4394
O
LEU
A
843
90.652
57.449
73.217
1.00
18.83
8

ATOM
4395
N
ILE
A
844
91.175
57.799
75.379
1.00
21.07
7

ATOM
4396
CA
ILE
A
844
91.154
56.381
75.693
1.00
20.34
6

ATOM
4397
CB
ILE
A
844
91.709
56.119
77.117
1.00
20.04
6

ATOM
4398
CG2
ILE
A
844
91.618
54.642
77.469
1.00
19.69
6

ATOM
4399
CG1
ILE
A
844
93.161
56.604
77.212
1.00
20.78
6

ATOM
4400
CD1
ILE
A
844
94.171
55.631
76.634
1.00
27.44
6

ATOM
4401
C
ILE
A
844
89.743
55.739
75.577
1.00
21.15
6

ATOM
4402
O
ILE
A
844
89.618
54.616
75.083
1.00
21.10
8

ATOM
4403
N
LEU
A
845
88.670
56.431
76.006
1.00
20.55
7

ATOM
4404
CA
LEU
A
845
87.277
55.903
75.926
1.00
23.92
6

ATOM
4405
CB
LEU
A
845
86.299
56.926
76.535
1.00
23.17
6

ATOM
4406
CG
LEU
A
845
85.670
56.624
77.890
1.00
27.74
6

ATOM
4407
CD1
LEU
A
845
86.482
55.575
78.649
1.00
27.88
6

ATOM
4408
CD2
LEU
A
845
85.529
57.897
78.698
1.00
21.27
6

ATOM
4409
C
LEU
A
845
86.852
55.680
74.497
1.00
23.24
6

ATOM
4410
O
LEU
A
845
86.360
54.608
74.112
1.00
22.70
8

ATOM
4411
N
GLN
A
846
87.077
56.728
73.741
1.00
22.52
7

ATOM
4412
CA
GLN
A
846
86.717
56.675
72.370
1.00
24.33
6

ATOM
4413
CB
GLN
A
846
87.069
57.959
71.655
1.00
25.76
6

ATOM
4414
CG
GLN
A
846
86.222
58.180
70.422
1.00
31.35
6

ATOM
4415
CD
GLN
A
846
84.741
57.988
70.738
1.00
35.35
6

ATOM
4416
OE1
GLN
A
846
84.140
58.754
71.500
1.00
38.19
8

ATOM
4417
NE2
GLN
A
846
83.951
57.030
70.263
1.00
37.33
7

ATOM
4418
C
GLN
A
846
87.393
55.504
71.689
1.00
23.13
6

ATOM
4419
O
GLN
A
846
86.754
54.835
70.872
1.00
24.23
8

ATOM
4420
N
ILE
A
847
88.661
55.228
72.016
1.00
23.30
7

ATOM
4421
CA
ILE
A
847
89.302
54.081
71.394
1.00
25.24
6

ATOM
4422
CB
ILE
A
847
90.805
54.025
71.696
1.00
24.57
6

ATOM
4423
CG2
ILE
A
847
91.401
52.714
71.223
1.00
24.69
6

ATOM
4424
CG1
ILE
A
847
91.519
55.198
71.021
1.00
26.75
6

ATOM
4425
CD1
ILE
A
847
93.023
55.167
71.171
1.00
27.11
6

ATOM
4426
C
ILE
A
847
88.590
52.847
71.917
1.00
25.46
6

ATOM
4427
O
ILE
A
847
88.419
51.847
71.223
1.00
26.70
8

ATOM
4428
N
LEU
A
848
88.162
52.937
73.174
1.00
24.23
7

ATOM
4429
CA
LEU
A
848
87.438
51.842
73.813
1.00
24.46
6

ATOM
4430
CB
LEU
A
848
87.125
52.192
75.277
1.00
23.96
6

ATOM
4431
CG
LEU
A
848
87.220
51.087
76.366
1.00
26.12
6

ATOM
4432
CD1
LEU
A
848
88.228
50.020
75.972
1.00
22.04
6

ATOM
4433
CD2
LEU
A
848
87.601
51.699
77.701
1.00
22.56
6

ATOM
4434
C
LEU
A
848
86.128
51.609
73.053
1.00
21.24
6

ATOM
4435
O
LEU
A
848
85.735
50.469
72.800
1.00
19.25
8

ATOM
4436
N
ARG
A
849
85.451
52.687
72.676
1.00
22.38
7

ATOM
4437
CA
ARG
A
849
84.207
52.541
71.932
1.00
21.46
6

ATOM
4438
CB
ARG
A
849
83.490
53.889
71.816
1.00
25.04
6

ATOM
4439
CG
ARG
A
849
82.986
54.429
73.165
1.00
29.55
6

ATOM
4440
CD
ARG
A
849
82.241
55.762
73.017
1.00
33.96
6

ATOM
4441
NE
ARG
A
849
80.955
55.762
73.718
1.00
36.92
7

ATOM
4442
CZ
ARG
A
849
80.654
56.543
74.754
1.00
38.79
6

ATOM
4443
NH1
ARG
A
849
81.545
57.407
75.227
1.00
37.36
7

ATOM
4444
NH2
ARG
A
849
79.452
56.460
75.324
1.00
39.00
7

ATOM
4445
C
ARG
A
849
84.497
51.948
70.552
1.00
22.58
6

ATOM
4446
O
ARG
A
849
83.683
51.196
69.997
1.00
23.09
8

ATOM
4447
N
ILE
A
850
85.662
52.264
69.998
1.00
21.39
7

ATOM
4448
CA
ILE
A
850
86.018
51.718
68.701
1.00
24.04
6

ATOM
4449
CB
ILE
A
850
87.279
52.385
68.155
1.00
26.95
6

ATOM
4450
CG2
ILE
A
850
87.798
51.608
66.961
1.00
23.93
6

ATOM
4451
CG1
ILE
A
850
86.955
53.841
67.793
1.00
28.31
6

ATOM
4452
CD1
ILE
A
850
88.136
54.626
67.313
1.00
28.18
6

ATOM
4453
C
ILE
A
850
86.248
50.213
68.839
1.00
25.30
6

ATOM
4454
O
ILE
A
850
85.786
49.418
68.001
1.00
22.28
8

ATOM
4455
N
MET
A
851
86.952
49.814
69.895
1.00
22.18
7

ATOM
4456
CA
MET
A
851
87.200
48.394
70.100
1.00
25.20
6

ATOM
4457
CB
MET
A
851
88.085
48.160
71.320
1.00
22.80
6

ATOM
4458
CG
MET
A
851
89.511
48.642
71.126
1.00
24.85
6

ATOM
4459
SD
MET
A
851
90.560
48.261
72.553
1.00
25.62
16

ATOM
4460
CE
MET
A
851
89.680
49.062
73.762
1.00
32.45
6

ATOM
4461
C
MET
A
851
85.895
47.626
70.233
1.00
27.14
6

ATOM
4462
O
MET
A
851
85.814
46.462
69.828
1.00
28.81
8

ATOM
4463
N
GLU
A
852
84.877
48.278
70.793
1.00
28.75
7

ATOM
4464
CA
GLU
A
852
83.562
47.665
70.941
1.00
29.10
6

ATOM
4465
CB
GLU
A
852
82.590
48.580
71.695
1.00
31.35
6

ATOM
4466
CG
GLU
A
852
81.937
48.011
72.937
1.00
37.95
6

ATOM
4467
CD
GLU
A
852
80.894
48.972
73.510
1.00
40.62
6

ATOM
4468
OE1
GLU
A
852
81.211
50.173
73.696
1.00
43.21
8

ATOM
4469
OE2
GLU
A
852
79.758
48.531
73.777
1.00
40.46
8

ATOM
4470
C
GLU
A
852
82.960
47.401
69.566
1.00
28.89
6

ATOM
4471
O
GLU
A
852
82.405
46.323
69.319
1.00
24.73
8

ATOM
4472
N
SER
A
853
83.037
48.396
68.681
1.00
28.85
7

ATOM
4473
CA
SER
A
853
82.473
48.242
67.348
1.00
31.66
6

ATOM
4474
CB
SER
A
853
82.587
49.543
66.546
1.00
31.63
6

ATOM
4475
OG
SER
A
853
83.931
49.853
66.230
1.00
39.87
8

ATOM
4476
C
SER
A
853
83.191
47.101
66.639
1.00
31.82
6

ATOM
4477
O
SER
A
853
82.560
46.283
65.979
1.00
34.71
8

ATOM
4478
N
ILE
A
854
84.507
47.041
66.791
1.00
32.37
7

ATOM
4479
CA
ILE
A
854
85.281
45.977
66.180
1.00
31.21
6

ATOM
4480
CB
ILE
A
854
86.780
46.097
66.525
1.00
31.90
6

ATOM
4481
CG2
ILE
A
854
87.506
44.807
66.169
1.00
28.76
6

ATOM
4482
CG1
ILE
A
854
87.392
47.290
65.779
1.00
30.08
6

ATOM
4483
CD1
ILE
A
854
88.807
47.605
66.201
1.00
30.97
6

ATOM
4484
C
ILE
A
854
84.757
44.634
66.682
1.00
34.17
6

ATOM
4485
O
ILE
A
854
84.441
43.765
65.860
1.00
33.61
8

ATOM
4486
N
TRP
A
855
84.653
44.463
67.998
1.00
33.62
7

ATOM
4487
CA
TRP
A
855
84.201
43.199
68.537
1.00
33.75
6

ATOM
4488
CB
TRP
A
855
84.285
43.268
70.067
1.00
30.90
6

ATOM
4489
CG
TRP
A
855
85.706
43.114
70.542
1.00
29.06
6

ATOM
4490
CD2
TRP
A
855
86.264
43.697
71.730
1.00
28.99
6

ATOM
4491
CE2
TRP
A
855
87.616
43.297
71.794
1.00
25.88
6

ATOM
4492
CE3
TRP
A
855
85.749
44.515
72.748
1.00
28.49
6

ATOM
4493
CD1
TRP
A
855
86.715
42.410
69.953
1.00
27.52
6

ATOM
4494
NE1
TRP
A
855
87.864
42.515
70.699
1.00
28.53
7

ATOM
4495
CZ2
TRP
A
855
88.468
43.684
72.836
1.00
27.73
6

ATOM
4496
CZ3
TRP
A
855
86.597
44.899
73.790
1.00
30.89
6

ATOM
4497
CH2
TRP
A
855
87.945
44.480
73.822
1.00
28.83
6

ATOM
4498
C
TRP
A
855
82.793
42.718
68.091
1.00
34.39
6

ATOM
4499
O
TRP
A
855
82.523
41.521
68.221
1.00
32.96
8

ATOM
4500
N
GLU
A
856
81.900
43.590
67.587
1.00
36.17
7

ATOM
4501
CA
GLU
A
856
80.543
43.165
67.201
1.00
39.23
6

ATOM
4502
CB
GLU
A
856
79.529
44.270
67.470
1.00
41.22
6

ATOM
4503
CG
GLU
A
856
78.358
44.240
66.499
1.00
44.51
6

ATOM
4504
CD
GLU
A
856
77.608
45.562
66.473
1.00
48.79
6

ATOM
4505
OE1
GLU
A
856
77.931
46.419
65.624
1.00
51.30
8

ATOM
4506
OE2
GLU
A
856
76.697
45.748
67.308
1.00
50.83
8

ATOM
4507
C
GLU
A
856
80.463
42.710
65.751
1.00
39.46
6

ATOM
4508
O
GLU
A
856
79.469
42.143
65.313
1.00
40.68
8

ATOM
4509
N
THR
A
857
81.525
42.964
64.980
1.00
41.39
7

ATOM
4510
CA
THR
A
857
81.624
42.468
63.607
1.00
41.68
6

ATOM
4511
CB
THR
A
857
82.863
42.928
62.836
1.00
41.15
6

ATOM
4512
OG1
THR
A
857
84.046
42.581
63.558
1.00
40.91
8

ATOM
4513
CG2
THR
A
857
82.825
44.418
62.612
1.00
41.66
6

ATOM
4514
C
THR
A
857
81.906
41.007
63.725
1.00
43.53
6

ATOM
4515
O
THR
A
857
81.746
40.210
62.800
1.00
44.76
8

ATOM
4516
N
GLU
A
858
82.346
40.659
64.912
1.00
43.81
7

ATOM
4517
CA
GLU
A
858
82.694
39.286
65.139
1.00
44.45
6

ATOM
4518
CB
GLU
A
858
84.187
39.211
65.484
1.00
44.95
6

ATOM
4519
CG
GLU
A
858
85.028
39.890
64.414
1.00
48.01
6

ATOM
4520
CD
GLU
A
858
86.359
39.203
64.207
1.00
50.19
6

ATOM
4521
OE1
GLU
A
858
87.146
39.653
63.362
1.00
50.25
8

ATOM
4522
OE2
GLU
A
858
86.614
38.200
64.920
1.00
51.36
8

ATOM
4523
C
GLU
A
858
81.755
38.637
66.140
1.00
44.35
6

ATOM
4524
O
GLU
A
858
82.129
37.729
66.899
1.00
45.05
8

ATOM
4525
N
SER
A
859
80.507
39.142
66.131
1.00
43.64
7

ATOM
4526
CA
SER
A
859
79.463
38.661
67.010
1.00
44.87
6

ATOM
4527
CB
SER
A
859
79.025
37.241
66.662
1.00
46.73
6

ATOM
4528
OG
SER
A
859
78.627
37.137
65.305
1.00
49.76
8

ATOM
4529
C
SER
A
859
80.000
38.665
68.424
1.00
44.35
6

ATOM
4530
O
SER
A
859
80.133
37.617
69.062
1.00
42.84
8

ATOM
4531
N
LEU
A
860
80.352
39.819
68.869
1.00
43.06
7

ATOM
4532
CA
LEU
A
860
80.864
39.787
70.167
1.00
41.98
6

ATOM
4533
CB
LEU
A
860
82.395
39.619
70.132
1.00
44.00
6

ATOM
4534
CG
LEU
A
860
82.937
38.323
69.472
1.00
45.82
6

ATOM
4535
CD1
LEU
A
860
84.459
38.395
69.296
1.00
44.32
6

ATOM
4536
CD2
LEU
A
860
82.547
37.103
70.299
1.00
45.98
6

ATOM
4537
C
LEU
A
860
80.400
40.992
70.887
1.00
40.30
6

ATOM
4538
O
LEU
A
860
80.358
42.111
70.390
1.00
35.80
8

ATOM
4539
N
ASP
A
861
80.042
40.692
72.077
1.00
37.98
7

ATOM
4540
CA
ASP
A
861
79.640
41.628
73.049
1.00
36.81
6

ATOM
4541
CB
ASP
A
861
78.150
41.579
73.331
1.00
38.21
6

ATOM
4542
CG
ASP
A
861
77.525
42.929
73.121
1.00
37.96
6

ATOM
4543
OD1
ASP
A
861
78.226
43.842
72.637
1.00
35.38
8

ATOM
4544
OD2
ASP
A
861
76.326
43.099
73.427
1.00
39.83
8

ATOM
4545
C
ASP
A
861
80.436
41.284
74.283
1.00
36.84
6

ATOM
4546
O
ASP
A
861
80.454
40.155
74.756
1.00
36.77
8

ATOM
4547
N
LEU
A
862
81.085
42.278
74.808
1.00
33.55
7

ATOM
4548
CA
LEU
A
862
81.904
42.038
75.975
1.00
31.00
6

ATOM
4549
CB
LEU
A
862
83.328
42.438
75.639
1.00
30.05
6

ATOM
4550
CG
LEU
A
862
83.896
41.557
74.539
1.00
32.50
6

ATOM
4551
CD1
LEU
A
862
84.710
40.420
75.141
1.00
29.68
6

ATOM
4552
CD2
LEU
A
862
82.769
41.006
73.660
1.00
33.90
6

ATOM
4553
C
LEU
A
862
81.342
42.731
77.193
1.00
30.43
6

ATOM
4554
O
LEU
A
862
81.368
42.203
78.305
1.00
29.81
8

ATOM
4555
N
CYS
A
863
80.815
43.935
76.948
1.00
28.33
7

ATOM
4556
CA
CYS
A
863
80.122
44.778
77.926
1.00
28.97
6

ATOM
4557
CB
CYS
A
863
79.391
43.874
78.917
1.00
28.01
6

ATOM
4558
SG
CYS
A
863
78.316
42.621
78.152
1.00
34.15
16

ATOM
4559
C
CYS
A
863
81.041
45.821
78.609
1.00
27.73
6

ATOM
4560
O
CYS
A
863
80.903
46.120
79.803
1.00
29.68
8

ATOM
4561
N
LEU
A
864
81.966
46.366
77.801
1.00
23.28
7

ATOM
4562
CA
LEU
A
864
82.878
47.410
78.300
1.00
22.60
6

ATOM
4563
CB
LEU
A
864
83.802
47.917
77.188
1.00
20.65
6

ATOM
4564
CG
LEU
A
864
84.125
46.896
76.070
1.00
23.75
6

ATOM
4565
CD1
LEU
A
864
85.202
47.445
75.140
1.00
24.03
6

ATOM
4566
CD2
LEU
A
864
84.568
45.571
76.677
1.00
19.96
6

ATOM
4567
C
LEU
A
864
81.979
48.491
78.835
1.00
22.64
6

ATOM
4568
O
LEU
A
864
80.763
48.413
78.652
1.00
22.47
8

ATOM
4569
N
LEU
A
865
82.516
49.504
79.486
1.00
24.08
7

ATOM
4570
CA
LEU
A
865
81.559
50.462
80.000
1.00
27.29
6

ATOM
4571
CB
LEU
A
865
81.187
50.097
81.414
1.00
28.60
6

ATOM
4572
CG
LEU
A
865
79.909
50.704
81.919
1.00
33.50
6

ATOM
4573
CD1
LEU
A
865
78.757
50.385
80.978
1.00
35.81
6

ATOM
4574
CD2
LEU
A
865
79.609
50.214
83.325
1.00
31.76
6

ATOM
4575
C
LEU
A
865
82.055
51.879
79.907
1.00
27.15
6

ATOM
4576
O
LEU
A
865
82.392
52.574
80.877
1.00
28.70
8

ATOM
4577
N
PRO
A
866
82.076
52.246
78.634
1.00
28.02
7

ATOM
4578
CD
PRO
A
866
82.583
51.235
77.717
1.00
27.98
6

ATOM
4579
CA
PRO
A
866
82.534
53.558
78.253
1.00
26.93
6

ATOM
4580
CB
PRO
A
866
82.466
53.450
76.728
1.00
27.28
6

ATOM
4581
CG
PRO
A
866
82.897
52.027
76.496
1.00
29.48
6

ATOM
4582
C
PRO
A
866
81.803
54.681
78.948
1.00
25.41
6

ATOM
4583
O
PRO
A
866
80.751
55.082
78.448
1.00
26.68
8

ATOM
4584
N
TYR
A
867
82.270
55.213
80.036
1.00
24.65
7

ATOM
4585
CA
TYR
A
867
81.483
56.259
80.657
1.00
23.67
6

ATOM
4586
CB
TYR
A
867
81.701
56.190
82.167
1.00
22.27
6

ATOM
4587
CG
TYR
A
867
83.153
56.256
82.477
1.00
20.52
6

ATOM
4588
CD1
TYR
A
867
83.735
57.506
82.658
1.00
20.96
6

ATOM
4589
CE1
TYR
A
867
85.086
57.631
82.962
1.00
22.88
6

ATOM
4590
CD2
TYR
A
867
83.959
55.125
82.610
1.00
20.74
6

ATOM
4591
CE2
TYR
A
867
85.309
55.237
82.910
1.00
21.17
6

ATOM
4592
CZ
TYR
A
867
85.866
56.493
83.085
1.00
21.63
6

ATOM
4593
OH
TYR
A
867
87.205
56.614
83.373
1.00
26.21
8

ATOM
4594
C
TYR
A
867
81.774
57.645
80.077
1.00
21.26
6

ATOM
4595
O
TYR
A
867
82.874
57.893
79.578
1.00
19.77
8

ATOM
4596
N
GLY
A
868
80.799
58.568
80.159
1.00
23.51
7

ATOM
4597
CA
GLY
A
868
80.932
59.912
79.593
1.00
22.67
6

ATOM
4598
C
GLY
A
868
82.032
60.797
80.237
1.00
23.18
6

ATOM
4599
O
GLY
A
868
82.191
60.782
81.457
1.00
21.51
8

ATOM
4600
N
CYS
A
869
82.769
61.550
79.419
1.00
21.35
7

ATOM
4601
CA
CYS
A
869
83.852
62.388
79.930
1.00
21.65
6

ATOM
4602
CB
CYS
A
869
85.106
61.546
80.200
1.00
22.44
6

ATOM
4603
SG
CYS
A
869
86.515
62.525
80.791
1.00
29.86
16

ATOM
4604
C
CYS
A
869
84.178
63.494
78.955
1.00
23.04
6

ATOM
4605
O
CYS
A
869
84.322
63.259
77.761
1.00
22.26
8

ATOM
4606
N
ILE
A
870
84.281
64.714
79.458
1.00
22.74
7

ATOM
4607
CA
ILE
A
870
84.577
65.840
78.590
1.00
22.94
6

ATOM
4608
CB
ILE
A
870
83.271
66.542
78.140
1.00
27.36
6

ATOM
4609
CG2
ILE
A
870
83.565
67.913
77.544
1.00
20.34
6

ATOM
4610
CG1
ILE
A
870
82.549
65.669
77.112
1.00
27.35
6

ATOM
4611
CD1
ILE
A
870
82.251
66.365
75.802
1.00
27.18
6

ATOM
4612
C
ILE
A
870
85.479
66.848
79.263
1.00
22.69
6

ATOM
4613
O
ILE
A
870
85.131
67.404
80.305
1.00
22.78
8

ATOM
4614
N
SER
A
871
86.648
67.064
78.670
1.00
21.95
7

ATOM
4615
CA
SER
A
871
87.566
68.037
79.215
1.00
20.58
6

ATOM
4616
CB
SER
A
871
88.974
67.826
78.670
1.00
20.62
6

ATOM
4617
OG
SER
A
871
89.820
68.909
79.013
1.00
21.45
8

ATOM
4618
C
SER
A
871
87.025
69.443
78.854
1.00
25.30
6

ATOM
4619
O
SER
A
871
86.885
69.733
77.665
1.00
22.73
8

ATOM
4620
N
THR
A
872
86.719
70.343
79.805
1.00
24.62
7

ATOM
4621
CA
THR
A
872
86.220
71.682
79.393
1.00
24.25
6

ATOM
4622
CB
THR
A
872
84.936
72.067
80.130
1.00
25.46
6

ATOM
4623
OG1
THR
A
872
85.153
71.958
81.542
1.00
24.15
8

ATOM
4624
CG2
THR
A
872
83.789
71.159
79.708
1.00
24.80
6

ATOM
4625
C
THR
A
872
87.313
72.764
79.581
1.00
26.84
6

ATOM
4626
O
THR
A
872
87.098
73.945
79.246
1.00
26.62
8

ATOM
4627
N
GLY
A
873
88.503
72.371
80.114
1.00
24.87
7

ATOM
4628
CA
GLY
A
873
89.609
73.311
80.346
1.00
27.57
6

ATOM
4629
C
GLY
A
873
90.950
72.696
80.781
1.00
32.09
6

ATOM
4630
O
GLY
A
873
91.085
71.469
80.863
1.00
32.02
8

ATOM
4631
N
ASP
A
874
91.954
73.568
81.060
1.00
32.51
7

ATOM
4632
CA
ASP
A
874
93.277
73.100
81.466
1.00
35.68
6

ATOM
4633
CB
ASP
A
874
94.257
74.222
81.780
1.00
39.63
6

ATOM
4634
CG
ASP
A
874
95.533
73.741
82.508
1.00
43.33
6

ATOM
4635
OD1
ASP
A
874
96.218
72.845
81.974
1.00
44.81
8

ATOM
4636
OD2
ASP
A
874
95.818
74.276
83.598
1.00
48.04
8

ATOM
4637
C
ASP
A
874
93.199
72.255
82.696
1.00
34.44
6

ATOM
4638
O
ASP
A
874
93.555
72.680
83.803
1.00
32.36
8

ATOM
4639
N
LYS
A
875
92.741
71.030
82.506
1.00
34.07
7

ATOM
4640
CA
LYS
A
875
92.664
70.191
83.656
1.00
34.58
6

ATOM
4641
CB
LYS
A
875
93.744
70.581
84.661
1.00
37.54
6

ATOM
4642
CG
LYS
A
875
95.151
70.297
84.167
1.00
41.83
6

ATOM
4643
CD
LYS
A
875
96.186
70.809
85.137
1.00
45.28
6

ATOM
4644
CE
LYS
A
875
96.200
72.333
85.185
1.00
49.42
6

ATOM
4645
NZ
LYS
A
875
97.118
72.841
86.243
1.00
49.43
7

ATOM
4646
C
LYS
A
875
91.314
70.239
84.298
1.00
32.61
6

ATOM
4647
O
LYS
A
875
91.103
69.561
85.307
1.00
30.76
8

ATOM
4648
N
ILE
A
876
90.395
71.001
83.774
1.00
29.12
7

ATOM
4649
CA
ILE
A
876
89.117
70.933
84.406
1.00
27.36
6

ATOM
4650
CB
ILE
A
876
88.602
72.326
84.801
1.00
27.59
6

ATOM
4651
CG2
ILE
A
876
88.572
73.226
83.564
1.00
28.62
6

ATOM
4652
CG1
ILE
A
876
87.235
72.293
85.471
1.00
31.32
6

ATOM
4653
CD1
ILE
A
876
86.822
73.620
86.082
1.00
36.42
6

ATOM
4654
C
ILE
A
876
88.165
70.247
83.461
1.00
25.67
6

ATOM
4655
O
ILE
A
876
88.241
70.426
82.244
1.00
23.93
8

ATOM
4656
N
GLY
A
877
87.257
69.452
83.981
1.00
26.35
7

ATOM
4657
CA
GLY
A
877
86.299
68.759
83.149
1.00
25.30
6

ATOM
4658
C
GLY
A
877
85.274
68.004
83.973
1.00
25.67
6

ATOM
4659
O
GLY
A
877
85.358
67.959
85.210
1.00
25.77
8

ATOM
4660
N
MET
A
878
84.308
67.419
83.266
1.00
24.50
7

ATOM
4661
CA
MET
A
878
83.234
66.637
83.869
1.00
24.77
6

ATOM
4662
CB
MET
A
878
81.876
67.139
83.391
1.00
27.37
6

ATOM
4663
CG
MET
A
878
81.682
66.983
81.881
1.00
30.59
6

ATOM
4664
SD
MET
A
878
80.168
67.768
81.303
1.00
37.68
16

ATOM
4665
CE
MET
A
878
80.021
69.149
82.497
1.00
33.74
6

ATOM
4666
C
MET
A
878
83.333
65.163
83.519
1.00
24.44
6

ATOM
4667
O
MET
A
878
83.796
64.801
82.439
1.00
22.09
8

ATOM
4668
N
ILE
A
879
82.852
64.331
84.435
1.00
23.81
7

ATOM
4669
CA
ILE
A
879
82.887
62.879
84.305
1.00
25.21
6

ATOM
4670
CB
ILE
A
879
83.990
62.290
85.231
1.00
28.14
6

ATOM
4671
CG2
ILE
A
879
83.994
60.767
85.165
1.00
24.50
6

ATOM
4672
CG1
ILE
A
879
85.356
62.856
84.828
1.00
28.36
6

ATOM
4673
CD1
ILE
A
879
86.456
62.566
85.817
1.00
33.59
6

ATOM
4674
C
ILE
A
879
81.528
62.312
84.706
1.00
25.42
6

ATOM
4675
O
ILE
A
879
80.940
62.729
85.706
1.00
27.54
8

ATOM
4676
N
GLU
A
880
81.022
61.363
83.924
1.00
22.89
7

ATOM
4677
CA
GLU
A
880
79.737
60.746
84.220
1.00
21.66
6

ATOM
4678
CB
GLU
A
680
79.307
59.829
83.067
1.00
23.33
6

ATOM
4679
CG
GLU
A
880
78.062
58.980
83.347
1.00
23.77
6

ATOM
4680
CD
GLU
A
880
77.625
58.123
82.142
1.00
27.52
6

ATOM
4681
OE1
GLU
A
880
76.607
57.409
82.252
1.00
27.19
8

ATOM
4682
OE2
GLU
A
880
78.294
58.158
81.086
1.00
26.96
8

ATOM
4683
C
GLU
A
880
79.817
59.916
85.490
1.00
23.74
6

ATOM
4684
O
GLU
A
880
80.807
59.213
85.708
1.00
21.46
8

ATOM
4685
N
ILE
A
881
78.759
59.845
86.304
1.00
23.28
7

ATOM
4686
CA
ILE
A
881
78.715
58.957
87.516
1.00
25.56
6

ATOM
4687
CB
ILE
A
881
78.047
59.726
88.701
1.00
25.02
6

ATOM
4688
CG2
ILE
A
881
77.703
58.750
89.811
1.00
26.07
6

ATOM
4689
CG1
ILE
A
881
78.899
60.865
89.268
1.00
24.22
6

ATOM
4690
CD1
ILE
A
881
78.331
61.474
90.533
1.00
28.10
6

ATOM
4691
C
ILE
A
881
77.908
57.634
87.150
1.00
25.01
6

ATOM
4692
O
ILE
A
881
76.776
57.786
86.711
1.00
23.48
8

ATOM
4693
N
VAL
A
882
78.399
56.353
87.261
1.00
24.51
7

ATOM
4694
CA
VAL
A
882
77.560
55.165
86.816
1.00
28.02
6

ATOM
4695
CB
VAL
A
882
78.492
54.055
86.225
1.00
24.82
6

ATOM
4696
CG1
VAL
A
882
77.709
52.778
85.958
1.00
26.06
6

ATOM
4697
CG2
VAL
A
882
79.162
54.544
84.953
1.00
24.28
6

ATOM
4698
C
VAL
A
882
76.576
54.553
87.905
1.00
27.84
6

ATOM
4699
O
VAL
A
882
77.006
54.332
89.035
1.00
29.61
8

ATOM
4700
N
LYS
A
883
75.235
54.292
87.557
1.00
32.08
7

ATOM
4701
CA
LYS
A
883
74.093
53.793
88.456
1.00
34.32
6

ATOM
4702
CB
LYS
A
883
72.761
53.910
87.705
1.00
38.24
6

ATOM
4703
CG
LYS
A
883
72.848
55.031
88.183
1.00
44.77
6

ATOM
4704
CD
LYS
A
883
72.471
56.383
87.923
1.00
47.85
6

ATOM
4705
CE
LYS
A
883
71.687
57.514
88.559
1.00
50.43
6

ATOM
4706
NZ
LYS
A
883
71.717
57.443
90.046
1.00
49.61
7

ATOM
4707
C
LYS
A
883
74.244
52.363
89.026
1.00
33.92
6

ATOM
4708
O
LYS
A
883
74.729
51.462
88.333
1.00
33.00
8

ATOM
4709
N
ASP
A
884
73.815
52.136
90.315
1.00
35.30
7

ATOM
4710
CA
ASP
A
884
74.044
50.861
90.987
1.00
36.94
6

ATOM
4711
CB
ASP
A
884
72.948
49.857
90.613
1.00
39.67
6

ATOM
4712
CG
ASP
A
884
71.577
50.278
91.114
1.00
43.46
6

ATOM
4713
OD1
ASP
A
884
71.512
51.078
92.075
1.00
44.96
8

ATOM
4714
OD2
ASP
A
884
70.565
49.799
90.558
1.00
44.13
8

ATOM
4715
C
ASP
A
884
75.411
50.262
90.683
1.00
36.20
6

ATOM
4716
O
ASP
A
884
75.515
49.109
90.268
1.00
37.44
8

ATOM
4717
N
ALA
A
885
76.455
51.052
90.902
1.00
34.91
7

ATOM
4718
CA
ALA
A
885
77.820
50.616
90.648
1.00
33.41
6

ATOM
4719
CB
ALA
A
885
78.346
51.268
89.378
1.00
32.80
6

ATOM
4720
C
ALA
A
885
78.712
50.980
91.818
1.00
32.11
6

ATOM
4721
O
ALA
A
885
78.555
52.036
92.426
1.00
31.46
8

ATOM
4722
N
THR
A
886
79.648
50.099
92.133
1.00
31.43
7

ATOM
4723
CA
THR
A
886
80.576
50.353
93.223
1.00
32.43
6

ATOM
4724
CB
THR
A
886
80.249
49.517
94.478
1.00
34.98
6

ATOM
4725
OG1
THR
A
886
78.870
49.679
94.815
1.00
39.61
8

ATOM
4726
CG2
THR
A
886
81.092
49.995
95.655
1.00
36.44
6

ATOM
4727
C
THR
A
886
81.954
49.950
92.758
1.00
31.65
6

ATOM
4728
O
THR
A
886
82.100
49.289
91.734
1.00
31.97
8

ATOM
4729
N
THR
A
887
82.964
50.351
93.518
1.00
28.84
7

ATOM
4730
CA
THR
A
887
84.332
50.019
93.199
1.00
28.70
6

ATOM
4731
CB
THR
A
887
85.273
51.101
93.744
1.00
30.92
6

ATOM
4732
OG1
THR
A
887
85.105
52.305
92.975
1.00
33.55
8

ATOM
4733
CG2
THR
A
887
86.709
50.644
93.680
1.00
33.87
6

ATOM
4734
C
THR
A
887
84.663
48.664
93.827
1.00
29.33
6

ATOM
4735
O
THR
A
887
84.160
48.324
94.908
1.00
24.17
8

ATOM
4736
N
ILE
A
888
85.486
47.882
93.136
1.00
28.56
7

ATOM
4737
CA
ILE
A
888
85.893
46.577
93.648
1.00
29.62
6

ATOM
4738
CB
ILE
A
888
86.807
45.838
92.630
1.00
30.35
6

ATOM
4739
CG2
ILE
A
888
87.544
44.690
93.309
1.00
31.74
6

ATOM
4740
CG1
ILE
A
888
85.964
45.253
91.494
1.00
31.68
6

ATOM
4741
CD1
ILE
A
888
85.340
46.272
90.583
1.00
37.93
6

ATOM
4742
C
ILE
A
888
86.627
46.771
94.984
1.00
30.72
6

ATOM
4743
O
ILE
A
888
86.579
45.908
95.867
1.00
29.52
8

ATOM
4744
N
ALA
A
889
87.297
47.910
95.134
1.00
29.97
7

ATOM
4745
CA
ALA
A
889
88.009
48.212
96.375
1.00
30.54
6

ATOM
4746
CB
ALA
A
889
88.838
49.484
96.211
1.00
30.03
6

ATOM
4747
C
ALA
A
889
87.006
48.386
97.523
1.00
31.08
6

ATOM
4748
O
ALA
A
889
87.197
47.840
98.615
1.00
29.12
8

ATOM
4749
N
LYS
A
890
85.937
49.148
97.284
1.00
31.92
7

ATOM
4750
CA
LYS
A
890
84.926
49.392
98.302
1.00
35.22
6

ATOM
4751
CB
LYS
A
890
83.903
50.415
97.807
1.00
36.48
6

ATOM
4752
CG
LYS
A
890
84.497
51.771
97.464
1.00
41.75
6

ATOM
4753
CD
LYS
A
890
84.934
52.514
98.715
1.00
46.13
6

ATOM
4754
CE
LYS
A
890
85.528
53.870
98.371
1.00
48.20
6

ATOM
4755
NZ
LYS
A
890
85.954
54.615
99.588
1.00
50.96
7

ATOM
4756
C
LYS
A
890
84.233
48.098
98.708
1.00
36.42
6

ATOM
4757
O
LYS
A
890
83.821
47.938
99.868
1.00
35.79
8

ATOM
4758
N
ILE
A
891
84.075
47.163
97.780
1.00
36.53
7

ATOM
4759
CA
ILE
A
891
83.438
45.893
98.098
1.00
37.57
6

ATOM
4760
CB
ILE
A
891
83.167
45.066
96.810
1.00
36.85
6

ATOM
4761
CG2
ILE
A
891
82.697
43.667
97.167
1.00
35.40
6

ATOM
4762
CG1
ILE
A
891
82.139
45.791
95.929
1.00
34.50
6

ATOM
4763
CD1
ILE
A
891
81.674
44.981
94.734
1.00
36.61
6

ATOM
4764
C
ILE
A
891
84.350
45.199
99.065
1.00
39.09
6

ATOM
4765
O
ILE
A
891
83.915
44.534
99.993
1.00
39.84
8

ATOM
4766
N
GLN
A
892
85.652
45.365
98.825
1.00
39.79
7

ATOM
4767
CA
GLN
A
892
86.633
44.770
99.719
1.00
42.00
6

ATOM
4768
CB
GLN
A
892
88.063
44.827
99.118
1.00
40.36
6

ATOM
4769
CG
GLN
A
892
88.391
43.737
98.095
1.00
40.46
6

ATOM
4770
CD
GLN
A
892
88.998
44.341
96.834
1.00
40.74
6

ATOM
4771
OE1
GLN
A
892
88.546
45.381
96.370
1.00
41.44
8

ATOM
4772
NE2
GLN
A
892
90.017
43.854
96.122
1.00
38.32
7

ATOM
4773
C
GLN
A
892
86.536
45.424
101.088
1.00
43.70
6

ATOM
4774
O
GLN
A
892
86.600
44.742
102.118
1.00
43.72
8

ATOM
4775
N
GLN
A
893
86.371
46.719
101.117
1.00
45.30
7

ATOM
4776
CA
GLN
A
893
86.180
47.394
102.361
1.00
48.89
6

ATOM
4777
CB
GLN
A
893
85.606
48.774
102.132
1.00
50.56
6

ATOM
4778
CG
GLN
A
893
86.603
49.869
102.230
1.00
55.16
6

ATOM
4779
CD
GLN
A
893
85.908
51.129
102.634
1.00
56.62
6

ATOM
4780
OE1
GLN
A
893
84.811
51.427
102.159
1.00
59.63
8

ATOM
4781
NE2
GLN
A
893
86.347
52.043
103.506
1.00
57.15
7

ATOM
4782
C
GLN
A
893
85.116
46.658
103.137
1.00
49.71
6

ATOM
4783
O
GLN
A
893
85.397
45.885
104.058
1.00
49.41
8

ATOM
4784
N
SER
A
894
83.865
46.931
102.722
1.00
51.67
7

ATOM
4785
CA
SER
A
894
82.659
46.377
103.320
1.00
54.29
6

ATOM
4786
CB
SER
A
894
81.597
46.181
102.250
1.00
54.36
6

ATOM
4787
OG
SER
A
894
81.271
47.414
101.633
1.00
56.48
8

ATOM
4788
C
SER
A
894
82.998
45.103
104.135
1.00
55.85
6

ATOM
4789
O
SER
A
894
83.117
45.213
105.358
1.00
54.78
8

ATOM
4790
N
THR
A
895
83.155
43.921
103.546
1.00
57.42
7

ATOM
4791
CA
THR
A
895
83.568
42.744
104.315
1.00
59.74
6

ATOM
4792
CB
THR
A
895
84.113
41.695
103.343
1.00
59.87
6

ATOM
4793
OG1
THR
A
895
83.144
41.443
102.319
1.00
61.40
8

ATOM
4794
CG2
THR
A
895
84.439
40.413
104.103
1.00
61.24
6

ATOM
4795
C
THR
A
895
84.634
43.121
105.354
1.00
61.01
6

ATOM
4796
O
THR
A
895
84.577
42.698
106.508
1.00
60.66
8

ATOM
4797
N
PHE
A
902
88.425
41.072
104.267
1.00
44.77
7

ATOM
4798
CA
PHE
A
902
88.334
39.748
104.863
1.00
44.55
6

ATOM
4799
CB
PHE
A
902
87.033
39.678
105.735
1.00
45.66
6

ATOM
4800
CG
PHE
A
902
87.112
39.536
107.278
1.00
46.64
6

ATOM
4801
CD1
PHE
A
902
86.478
40.439
108.142
1.00
45.62
6

ATOM
4802
CD2
PHE
A
902
87.781
38.469
107.840
1.00
46.88
6

ATOM
4803
CE1
PHE
A
902
86.511
40.253
109.514
1.00
47.22
6

ATOM
4804
CE2
PHE
A
902
87.789
38.275
109.209
1.00
47.50
6

ATOM
4805
CZ
PHE
A
902
87.152
39.155
110.062
1.00
46.65
6

ATOM
4806
C
PHE
A
902
88.542
38.658
103.754
1.00
43.94
6

ATOM
4807
O
PHE
A
902
89.436
37.830
103.980
1.00
44.97
8

ATOM
4808
N
LYS
A
903
87.831
38.567
102.581
1.00
44.56
7

ATOM
4809
CA
LYS
A
903
88.264
37.491
101.650
1.00
44.97
6

ATOM
4810
CB
LYS
A
903
87.791
36.105
102.172
1.00
46.98
6

ATOM
4811
CG
LYS
A
903
86.839
36.095
103.344
1.00
49.93
6

ATOM
4812
CD
LYS
A
903
85.905
34.900
103.278
1.00
53.08
6

ATOM
4813
CE
LYS
A
903
86.138
33.919
104.415
1.00
54.60
6

ATOM
4814
NZ
LYS
A
903
85.499
32.603
104.162
1.00
56.34
7

ATOM
4815
C
LYS
A
903
87.918
37.545
100.136
1.00
44.75
6

ATOM
4816
O
LYS
A
903
87.235
38.434
99.607
1.00
43.97
8

ATOM
4817
N
ASP
A
904
88.469
36.465
99.481
1.00
43.31
7

ATOM
4818
CA
ASP
A
904
88.478
35.994
98.049
1.00
43.42
6

ATOM
4819
CB
ASP
A
904
89.423
34.747
97.912
1.00
43.24
6

ATOM
4820
CG
ASP
A
904
90.910
34.977
97.619
1.00
43.13
6

ATOM
4821
OD1
ASP
A
904
91.625
33.993
97.353
1.00
42.69
8

ATOM
4822
OD2
ASP
A
904
91.338
36.140
97.671
1.00
44.09
8

ATOM
4823
C
ASP
A
904
87.096
35.620
97.516
1.00
42.95
6

ATOM
4824
O
ASP
A
904
86.927
35.337
96.331
1.00
42.01
8

ATOM
4825
N
GLU
A
905
86.109
35.642
98.428
1.00
41.53
7

ATOM
4826
CA
GLU
A
905
84.691
35.323
98.206
1.00
41.31
6

ATOM
4827
CB
GLU
A
905
84.158
34.364
99.277
1.00
44.25
6

ATOM
4828
CG
GLU
A
905
84.859
33.015
99.349
1.00
49.36
6

ATOM
4829
CD
GLU
A
905
84.304
32.136
100.463
1.00
53.55
6

ATOM
4830
OE1
GLU
A
905
84.437
32.513
101.650
1.00
55.59
8

ATOM
4831
OE2
GLU
A
905
83.731
31.070
100.154
1.00
56.26
8

ATOM
4832
C
GLU
A
905
83.838
36.586
98.236
1.00
38.94
6

ATOM
4833
O
GLU
A
905
82.670
36.556
97.853
1.00
37.89
8

ATOM
4834
N
VAL
A
906
84.416
37.686
98.697
1.00
38.17
7

ATOM
4835
CA
VAL
A
906
83.700
38.955
98.815
1.00
37.24
6

ATOM
4836
CB
VAL
A
906
84.680
40.100
99.160
1.00
40.88
6

ATOM
4837
CG1
VAL
A
906
83.901
41.361
99.536
1.00
43.77
6

ATOM
4838
CG2
VAL
A
906
85.601
39.673
100.296
1.00
41.91
6

ATOM
4839
C
VAL
A
906
82.877
39.395
97.604
1.00
35.69
6

ATOM
4840
O
VAL
A
906
81.726
39.799
97.746
1.00
33.85
8

ATOM
4841
N
LEU
A
907
83.463
39.321
96.415
1.00
36.15
7

ATOM
4842
CA
LEU
A
907
82.762
39.757
95.207
1.00
35.22
6

ATOM
4843
CB
LEU
A
907
83.700
39.720
93.996
1.00
35.57
6

ATOM
4844
CG
LEU
A
907
83.596
40.895
93.012
1.00
37.66
6

ATOM
4845
CD1
LEU
A
907
84.311
40.517
91.726
1.00
37.57
6

ATOM
4846
CD2
LEU
A
907
82.143
41.248
92.727
1.00
35.68
6

ATOM
4847
C
LEU
A
907
81.544
38.897
94.931
1.00
33.81
6

ATOM
4848
O
LEU
A
907
80.441
39.410
94.686
1.00
32.25
8

ATOM
4849
N
ASN
A
908
81.737
37.585
94.973
1.00
33.23
7

ATOM
4850
CA
ASN
A
908
80.630
36.671
94.726
1.00
33.17
6

ATOM
4851
CB
ASN
A
908
81.121
35.222
94.773
1.00
34.36
6

ATOM
4852
CG
ASN
A
908
80.099
34.239
94.217
1.00
36.86
6

ATOM
4853
OD1
ASN
A
908
79.532
33.428
94.954
1.00
34.79
8

ATOM
4854
ND2
ASN
A
908
79.852
34.318
92.909
1.00
33.09
7

ATOM
4855
C
ASN
A
908
79.520
36.907
95.751
1.00
33.36
6

ATOM
4856
O
ASN
A
908
78.340
36.931
95.398
1.00
31.52
8

ATOM
4857
N
HIS
A
909
79.905
37.081
97.023
1.00
34.07
7

ATOM
4858
CA
HIS
A
909
78.916
37.367
98.048
1.00
35.84
6

ATOM
4859
CB
HIS
A
909
79.498
37.797
99.371
1.00
41.33
6

ATOM
4860
CG
HIS
A
909
78.338
37.833
100.394
1.00
46.80
6

ATOM
4861
CD2
HIS
A
909
77.854
36.843
101.185
1.00
48.28
6

ATOM
4862
ND1
HIS
A
909
77.564
38.944
100.644
1.00
48.43
7

ATOM
4863
CE1
HIS
A
909
76.648
38.638
101.555
1.00
49.32
6

ATOM
4864
NE2
HIS
A
909
76.804
37.369
101.898
1.00
49.80
7

ATOM
4865
C
HIS
A
909
78.097
38.601
97.763
1.00
35.30
6

ATOM
4866
O
HIS
A
909
76.872
38.606
97.795
1.00
34.56
8

ATOM
4867
N
TRP
A
910
78.818
39.675
97.408
1.00
34.97
7

ATOM
4868
CA
TRP
A
910
78.205
40.955
97.071
1.00
32.70
6

ATOM
4869
CB
TRP
A
910
79.297
41.952
96.682
1.00
33.23
6

ATOM
4870
CG
TRP
A
910
78.802
43.328
96.494
1.00
33.00
6

ATOM
4871
CD2
TRP
A
910
78.419
43.936
95.259
1.00
34.62
6

ATOM
4872
CE2
TRP
A
910
78.023
45.261
95.551
1.00
35.38
6

ATOM
4873
CE3
TRP
A
910
78.373
43.492
93.929
1.00
33.89
6

ATOM
4874
CD1
TRP
A
910
78.624
44.275
97.463
1.00
34.79
6

ATOM
4875
NE1
TRP
A
910
78.158
45.440
96.904
1.00
35.64
7

ATOM
4876
CZ2
TRP
A
910
77.585
46.147
94.562
1.00
35.81
6

ATOM
4877
CZ3
TRP
A
910
77.940
44.366
92.948
1.00
33.51
6

ATOM
4878
CH2
TRP
A
910
77.551
45.683
93.269
1.00
37.11
6

ATOM
4879
C
TRP
A
910
77.189
40.835
95.930
1.00
31.61
6

ATOM
4880
O
TRP
A
910
76.049
41.282
96.055
1.00
32.08
8

ATOM
4881
N
LEU
A
911
77.597
40.241
94.814
1.00
31.87
7

ATOM
4882
CA
LEU
A
911
76.680
40.086
93.681
1.00
34.08
6

ATOM
4883
CB
LEU
A
911
77.386
39.433
92.490
1.00
34.75
6

ATOM
4884
CG
LEU
A
911
78.126
40.369
91.524
1.00
38.89
6

ATOM
4885
CD1
LEU
A
911
78.802
39.536
90.431
1.00
37.09
6

ATOM
4886
CD2
LEU
A
911
77.139
41.372
90.905
1.00
37.39
6

ATOM
4887
C
LEU
A
911
75.436
39.279
94.039
1.00
33.11
6

ATOM
4888
O
LEU
A
911
74.325
39.607
93.606
1.00
34.10
8

ATOM
4889
N
LYS
A
912
75.615
38.220
94.820
1.00
32.64
7

ATOM
4890
CA
LYS
A
912
74.482
37.402
95.220
1.00
35.60
6

ATOM
4891
CB
LYS
A
912
74.955
36.143
95.955
1.00
38.04
6

ATOM
4892
CG
LYS
A
912
73.812
35.246
96.448
1.00
44.73
6

ATOM
4893
CD
LYS
A
912
72.804
34.944
95.339
1.00
47.24
6

ATOM
4894
CE
LYS
A
912
71.624
34.137
95.850
1.00
50.86
6

ATOM
4895
NZ
LYS
A
912
70.649
33.818
94.770
1.00
51.37
7

ATOM
4896
C
LYS
A
912
73.528
38.194
96.108
1.00
36.43
6

ATOM
4897
O
LYS
A
912
72.310
38.066
95.990
1.00
36.69
8

ATOM
4898
N
GLU
A
913
74.070
39.030
96.989
1.00
37.80
7

ATOM
4899
CA
GLU
A
913
73.204
39.813
97.862
1.00
39.75
6

ATOM
4900
CB
GLU
A
913
74.005
40.405
99.022
1.00
44.08
6

ATOM
4901
CG
GLU
A
913
73.149
41.045
100.105
1.00
50.66
6

ATOM
4902
CD
GLU
A
913
72.366
40.024
100.907
1.00
53.61
6

ATOM
4903
OE1
GLU
A
913
72.503
38.815
100.626
1.00
56.35
8

ATOM
4904
OE2
GLU
A
913
71.613
40.434
101.816
1.00
55.71
8

ATOM
4905
C
GLU
A
913
72.494
40.917
97.086
1.00
39.33
6

ATOM
4906
O
GLU
A
913
71.367
41.287
97.427
1.00
37.98
8

ATOM
4907
N
LYS
A
914
73.125
41.459
96.030
1.00
38.45
7

ATOM
4908
CA
LYS
A
914
72.524
42.536
95.239
1.00
38.52
6

ATOM
4909
CB
LYS
A
914
73.612
43.302
94.518
1.00
38.73
6

ATOM
4910
CG
LYS
A
914
74.338
44.302
95.400
1.00
39.67
6

ATOM
4911
CD
LYS
A
914
73.399
45.385
95.900
1.00
41.54
6

ATOM
4912
CE
LYS
A
914
74.138
46.382
96.782
1.00
44.62
6

ATOM
4913
NZ
LYS
A
914
73.264
47.516
97.196
1.00
45.99
7

ATOM
4914
C
LYS
A
914
71.475
42.068
94.249
1.00
39.89
6

ATOM
4915
O
LYS
A
914
70.618
42.853
93.828
1.00
40.63
8

ATOM
4916
N
SER
A
915
71.498
40.800
93.874
1.00
39.59
7

ATOM
4917
CA
SER
A
915
70.497
40.282
92.954
1.00
40.88
6

ATOM
4918
CB
SER
A
915
71.159
39.316
91.987
1.00
41.88
6

ATOM
4919
OG
SER
A
915
71.605
38.155
92.665
1.00
45.55
8

ATOM
4920
C
SER
A
915
69.374
39.519
93.655
1.00
41.11
6

ATOM
4921
O
SER
A
915
69.618
38.709
94.547
1.00
41.13
8

ATOM
4922
N
PRO
A
916
68.136
39.809
93.222
1.00
41.73
7

ATOM
4923
CD
PRO
A
916
67.687
41.222
93.300
1.00
42.00
6

ATOM
4924
CA
PRO
A
916
66.984
39.051
93.749
1.00
41.34
6

ATOM
4925
CB
PRO
A
916
65.795
39.751
93.164
1.00
42.05
6

ATOM
4926
CG
PRO
A
916
66.198
41.162
93.242
1.00
41.79
6

ATOM
4927
C
PRO
A
916
67.003
37.570
93.498
1.00
42.44
6

ATOM
4928
O
PRO
A
916
67.617
36.755
94.172
1.00
42.11
8

ATOM
4929
N
THR
A
917
66.253
37.323
92.441
1.00
41.69
7

ATOM
4930
CA
THR
A
917
66.005
36.060
91.833
1.00
40.36
6

ATOM
4931
CB
THR
A
917
65.071
36.248
90.630
1.00
40.33
6

ATOM
4932
OG1
THR
A
917
64.656
34.975
90.123
1.00
36.52
8

ATOM
4933
CG2
THR
A
917
65.771
37.039
89.548
1.00
40.53
6

ATOM
4934
C
THR
A
917
67.279
35.491
91.385
1.00
41.31
6

ATOM
4935
O
THR
A
917
68.052
36.133
90.684
1.00
40.05
8

ATOM
4936
N
GLU
A
918
67.505
34.302
91.761
1.00
41.19
7

ATOM
4937
CA
GLU
A
918
68.664
33.720
91.272
1.00
43.74
6

ATOM
4938
CB
GLU
A
918
68.674
32.250
91.618
1.00
47.26
6

ATOM
4939
CG
GLU
A
918
69.700
31.900
92.648
1.00
51.95
6

ATOM
4940
CD
GLU
A
918
71.096
32.096
92.090
1.00
54.03
6

ATOM
4941
OE1
GLU
A
918
71.392
31.538
91.012
1.00
56.27
8

ATOM
4942
OE2
GLU
A
918
71.902
32.803
92.729
1.00
54.71
8

ATOM
4943
C
GLU
A
918
68.736
33.934
89.786
1.00
42.74
6

ATOM
4944
O
GLU
A
918
69.809
34.195
89.262
1.00
43.18
8

ATOM
4945
N
GLU
A
919
67.604
33.840
89.084
1.00
42.58
7

ATOM
4946
CA
GLU
A
919
67.677
34.060
87.644
1.00
42.91
6

ATOM
4947
CB
GLU
A
919
66.297
34.244
87.004
1.00
45.76
6

ATOM
4948
CG
GLU
A
919
65.548
35.497
87.403
1.00
53.56
6

ATOM
4949
CD
GLU
A
919
64.294
35.757
86.575
1.00
57.82
6

ATOM
4950
OE1
GLU
A
919
64.427
36.020
85.355
1.00
59.06
8

ATOM
4951
OE2
GLU
A
919
63.178
35.698
87.146
1.00
58.73
8

ATOM
4952
C
GLU
A
919
68.598
35.252
87.403
1.00
40.15
6

ATOM
4953
O
GLU
A
919
69.588
35.117
86.675
1.00
38.49
8

ATOM
4954
N
LYS
A
920
68.283
36.438
87.996
1.00
37.55
7

ATOM
4955
CA
LYS
A
920
69.083
37.659
87.763
1.00
37.31
6

ATOM
4956
CB
LYS
A
920
68.439
38.873
88.406
1.00
36.74
6

ATOM
4957
CG
LYS
A
920
67.011
39.107
87.971
1.00
40.50
6

ATOM
4958
CD
LYS
A
920
66.540
40.502
88.363
1.00
42.38
6

ATOM
4959
CE
LYS
A
920
65.326
40.937
87.554
1.00
44.62
6

ATOM
4960
NZ
LYS
A
920
64.583
42.038
88.226
1.00
48.16
7

ATOM
4961
C
LYS
A
920
70.510
37.550
88.264
1.00
35.44
6

ATOM
4962
O
LYS
A
920
71.329
38.446
88.072
1.00
36.26
8

ATOM
4963
N
PHE
A
921
70.834
36.426
88.924
1.00
32.20
7

ATOM
4964
CA
PHE
A
921
72.184
36.244
89.412
1.00
32.75
6

ATOM
4965
CB
PHE
A
921
72.218
35.570
90.765
1.00
30.95
6

ATOM
4966
CG
PHE
A
921
73.593
35.151
91.109
1.00
30.75
6

ATOM
4967
CD1
PHE
A
921
74.599
36.097
91.285
1.00
33.00
6

ATOM
4968
CD2
PHE
A
921
73.899
33.810
91.281
1.00
31.91
6

ATOM
4969
CE1
PHE
A
921
75.892
35.713
91.627
1.00
32.56
6

ATOM
4970
CE2
PHE
A
921
75.190
33.416
91.654
1.00
31.39
6

ATOM
4971
CZ
PHE
A
921
76.187
34.372
91.825
1.00
31.78
6

ATOM
4972
C
PHE
A
921
73.020
35.464
88.400
1.00
33.97
6

ATOM
4973
O
PHE
A
921
74.026
35.978
87.929
1.00
34.50
8

ATOM
4974
N
GLN
A
922
72.624
34.245
88.071
1.00
32.35
7

ATOM
4975
CA
GLN
A
922
73.381
33.522
87.062
1.00
32.77
6

ATOM
4976
CB
GLN
A
922
72.692
32.223
86.617
1.00
32.57
6

ATOM
4977
CG
GLN
A
922
73.070
30.933
87.377
1.00
33.59
6

ATOM
4978
CD
GLN
A
922
74.525
30.811
87.789
1.00
33.56
6

ATOM
4979
OE1
GLN
A
922
75.436
31.061
87.001
1.00
38.03
8

ATOM
4980
NE2
GLN
A
922
74.960
30.424
88.982
1.00
30.72
7

ATOM
4981
C
GLN
A
922
73.542
34.509
85.899
1.00
31.31
6

ATOM
4982
O
GLN
A
922
74.576
34.512
85.245
1.00
32.17
8

ATOM
4983
N
ALA
A
923
72.543
35.362
85.627
1.00
30.57
7

ATOM
4984
CA
ALA
A
923
72.632
36.352
84.507
1.00
30.26
6

ATOM
4985
CB
ALA
A
923
71.332
37.106
84.326
1.00
30.08
6

ATOM
4986
C
ALA
A
923
73.778
37.341
84.779
1.00
31.19
6

ATOM
4987
O
ALA
A
923
74.543
37.700
83.888
1.00
31.12
8

ATOM
4988
N
ALA
A
924
73.863
37.769
86.039
1.00
29.64
7

ATOM
4989
CA
ALA
A
924
74.876
38.680
86.510
1.00
28.94
6

ATOM
4990
CB
ALA
A
924
74.591
39.105
87.933
1.00
29.70
6

ATOM
4991
C
ALA
A
924
76.259
38.033
86.419
1.00
29.17
6

ATOM
4992
O
ALA
A
924
77.226
38.671
85.976
1.00
28.41
8

ATOM
4993
N
VAL
A
925
76.358
36.773
86.856
1.00
27.66
7

ATOM
4994
CA
VAL
A
925
77.600
36.059
86.766
1.00
27.21
6

ATOM
4995
CB
VAL
A
925
77.475
34.644
87.392
1.00
28.63
6

ATOM
4996
CG1
VAL
A
925
78.763
33.870
87.230
1.00
28.37
6

ATOM
4997
CG2
VAL
A
925
77.074
34.743
88.856
1.00
25.58
6

ATOM
4998
C
VAL
A
925
77.997
35.951
85.296
1.00
26.27
6

ATOM
4999
O
VAL
A
925
79.182
36.081
84.969
1.00
25.78
8

ATOM
5000
N
GLU
A
926
77.051
35.707
84.371
1.00
29.62
7

ATOM
5001
CA
GLU
A
926
77.458
35.621
82.945
1.00
30.79
6

ATOM
5002
CB
GLU
A
926
76.420
34.947
82.051
1.00
32.29
6

ATOM
5003
CG
GLU
A
926
77.076
33.752
81.363
1.00
38.41
6

ATOM
5004
CD
GLU
A
926
76.153
32.921
80.496
1.00
44.82
6

ATOM
5005
OE1
GLU
A
926
75.191
33.497
79.915
1.00
46.32
8

ATOM
5006
OE2
GLU
A
926
76.383
31.691
80.408
1.00
47.36
8

ATOM
5007
C
GLU
A
926
77.812
36.982
82.388
1.00
30.93
6

ATOM
5008
O
GLU
A
926
78.601
37.088
81.449
1.00
29.08
8

ATOM
5009
N
ARG
A
927
77.253
38.028
82.947
1.00
30.71
7

ATOM
5010
CA
ARG
A
927
77.623
39.331
82.464
1.00
30.76
6

ATOM
5011
CB
ARG
A
927
76.632
40.377
82.981
1.00
33.32
6

ATOM
5012
CG
ARG
A
927
76.500
41.594
82.088
1.00
35.68
6

ATOM
5013
CD
ARG
A
927
75.393
42.496
82.583
1.00
39.83
6

ATOM
5014
NE
ARG
A
927
74.941
43.404
81.533
1.00
45.39
7

ATOM
5015
CZ
ARG
A
927
74.252
43.021
80.462
1.00
46.78
6

ATOM
5016
NH1
ARG
A
927
73.922
41.742
80.297
1.00
45.40
7

ATOM
5017
NH2
ARG
A
927
73.879
43.914
79.551
1.00
46.12
7

ATOM
5018
C
ARG
A
927
79.031
39.682
82.922
1.00
28.13
6

ATOM
5019
O
ARG
A
927
79.757
40.405
82.235
1.00
26.33
8

ATOM
5020
N
PHE
A
928
79.408
39.163
84.089
1.00
26.77
7

ATOM
5021
CA
PHE
A
928
80.732
39.389
84.665
1.00
27.71
6

ATOM
5022
CB
PHE
A
928
80.773
38.912
86.121
1.00
28.88
6

ATOM
5023
CG
PHE
A
928
82.141
38.999
86.743
1.00
28.68
6

ATOM
5024
CD1
PHE
A
928
82.651
40.225
87.171
1.00
28.32
6

ATOM
5025
CD2
PHE
A
928
82.935
37.864
86.871
1.00
26.65
6

ATOM
5026
CE1
PHE
A
928
83.933
40.318
87.716
1.00
26.88
6

ATOM
5027
CE2
PHE
A
928
84.214
37.947
87.412
1.00
27.96
6

ATOM
5028
CZ
PHE
A
928
84.714
39.175
87.835
1.00
27.48
6

ATOM
5029
C
PHE
A
928
81.811
38.639
83.890
1.00
26.97
6

ATOM
5030
O
PHE
A
928
82.916
39.139
83.693
1.00
28.16
8

ATOM
5031
N
VAL
A
929
81.504
37.418
83.478
1.00
26.50
7

ATOM
5032
CA
VAL
A
929
82.476
36.632
82.734
1.00
24.93
6

ATOM
5033
CB
VAL
A
929
81.915
35.221
82.413
1.00
25.58
6

ATOM
5034
CG1
VAL
A
929
82.761
34.539
81.347
1.00
25.40
6

ATOM
5035
CG2
VAL
A
929
81.923
34.374
83.688
1.00
25.05
6

ATOM
5036
C
VAL
A
929
82.829
37.378
81.455
1.00
22.94
6

ATOM
5037
O
VAL
A
929
83.993
37.629
81.178
1.00
24.72
8

ATOM
5038
N
TYR
A
930
81.809
37.760
80.698
1.00
23.58
7

ATOM
5039
CA
TYR
A
930
82.006
38.492
79.458
1.00
26.14
6

ATOM
5040
CB
TYR
A
930
80.668
38.713
78.762
1.00
27.98
6

ATOM
5041
CG
TYR
A
930
80.173
37.530
77.966
1.00
36.84
6

ATOM
5042
CD1
TYR
A
930
79.746
36.362
78.600
1.00
38.14
6

ATOM
5043
CE1
TYR
A
930
79.286
35.274
77.863
1.00
41.27
6

ATOM
5044
CD2
TYR
A
930
80.128
37.577
76.569
1.00
38.11
6

ATOM
5045
CE2
TYR
A
930
79.671
36.493
75.824
1.00
40.99
6

ATOM
5046
CZ
TYR
A
930
79.252
35.347
76.477
1.00
42.07
6

ATOM
5047
OH
TYR
A
930
78.801
34.269
75.744
1.00
45.19
8

ATOM
5048
C
TYR
A
930
82.695
39.850
79.657
1.00
25.01
6

ATOM
5049
O
TYR
A
930
83.724
40.115
79.036
1.00
25.77
8

ATOM
5050
N
SER
A
931
82.132
40.708
80.510
1.00
24.83
7

ATOM
5051
CA
SER
A
931
82.717
42.040
80.739
1.00
22.92
6

ATOM
5052
CB
SER
A
931
81.852
42.870
81.714
1.00
25.22
6

ATOM
5053
OG
SER
A
931
81.823
42.324
83.032
1.00
26.27
8

ATOM
5054
C
SER
A
931
84.149
41.933
81.246
1.00
23.43
6

ATOM
5055
O
SER
A
931
85.016
42.721
80.860
1.00
21.98
8

ATOM
5056
N
CYS
A
932
84.414
40.949
82.099
1.00
23.61
7

ATOM
5057
CA
CYS
A
932
85.764
40.771
82.599
1.00
23.47
6

ATOM
5058
CB
CYS
A
932
85.818
39.637
83.625
1.00
25.33
6

ATOM
5059
SG
CYS
A
932
87.438
39.452
84.403
1.00
33.59
16

ATOM
5060
C
CYS
A
932
86.689
40.451
81.424
1.00
24.10
6

ATOM
5061
O
CYS
A
932
87.764
41.030
81.294
1.00
23.84
8

ATOM
5062
N
ALA
A
933
86.271
39.525
80.563
1.00
25.16
7

ATOM
5063
CA
ALA
A
933
87.078
39.157
79.396
1.00
25.29
6

ATOM
5064
CB
ALA
A
933
86.387
38.026
78.604
1.00
23.73
6

ATOM
5065
C
ALA
A
933
87.270
40.388
78.500
1.00
24.29
6

ATOM
5066
O
ALA
A
933
86.368
40.659
78.022
1.00
24.42
8

ATOM
5067
N
GLY
A
934
86.189
41.125
78.267
1.00
24.49
7

ATOM
5068
CA
GLY
A
934
86.281
42.320
77.442
1.00
23.51
6

ATOM
5069
C
GLY
A
934
87.325
43.298
77.964
1.00
23.93
6

ATOM
5070
O
GLY
A
934
88.160
43.782
77.205
1.00
24.08
8

ATOM
5071
N
TYR
A
935
87.300
43.597
79.260
1.00
22.56
7

ATOM
5072
CA
TYR
A
935
88.288
44.534
79.785
1.00
22.62
6

ATOM
5073
CB
TYR
A
935
87.838
45.088
81.150
1.00
21.28
6

ATOM
5074
CG
TYR
A
935
87.022
46.355
80.997
1.00
17.20
6

ATOM
5075
CD1
TYR
A
935
85.637
46.310
80.895
1.00
16.09
6

ATOM
5076
CE1
TYR
A
935
84.889
47.470
80.631
1.00
20.12
6

ATOM
5077
CD2
TYR
A
935
87.659
47.599
80.835
1.00
21.46
6

ATOM
5078
CE2
TYR
A
935
86.917
48.769
80.551
1.00
18.58
6

ATOM
5079
CZ
TYR
A
935
85.544
48.692
80.455
1.00
16.08
6

ATOM
5080
OH
TYR
A
935
84.814
49.823
80.170
1.00
21.37
8

ATOM
5081
C
TYR
A
935
89.705
43.966
79.860
1.00
21.52
6

ATOM
5082
O
TYR
A
935
90.671
44.695
79.674
1.00
21.37
8

ATOM
5083
N
CYS
A
936
89.850
42.672
80.112
1.00
23.71
7

ATOM
5084
CA
CYS
A
936
91.197
42.107
80.173
1.00
23.92
6

ATOM
5085
CB
CYS
A
936
91.164
40.631
80.592
1.00
28.07
6

ATOM
5086
SG
CYS
A
936
90.899
40.315
82.385
1.00
30.68
16

ATOM
5087
C
CYS
A
936
91.860
42.236
78.807
1.00
25.62
6

ATOM
5088
O
CYS
A
936
93.036
42.570
78.707
1.00
27.39
8

ATOM
5089
N
VAL
A
937
91.102
41.977
77.746
1.00
25.56
7

ATOM
5090
CA
VAL
A
937
91.657
42.079
76.400
1.00
25.96
6

ATOM
5091
CB
VAL
A
937
90.721
41.422
75.351
1.00
25.04
6

ATOM
5092
CG1
VAL
A
937
91.234
41.692
73.948
1.00
23.98
6

ATOM
5093
CG2
VAL
A
937
90.634
39.910
75.608
1.00
28.43
6

ATOM
5094
C
VAL
A
937
91.891
43.540
76.015
1.00
22.98
6

ATOM
5095
O
VAL
A
937
92.974
43.894
75.581
1.00
19.75
8

ATOM
5096
N
ALA
A
938
90.869
44.377
76.175
1.00
23.05
7

ATOM
5097
CA
ALA
A
938
90.987
45.788
75.836
1.00
23.27
6

ATOM
5098
CB
ALA
A
938
89.683
46.514
76.163
1.00
21.59
6

ATOM
5099
C
ALA
A
938
92.153
46.478
76.537
1.00
23.00
6

ATOM
5100
O
ALA
A
938
92.992
47.112
75.895
1.00
23.96
8

ATOM
5101
N
THR
A
939
92.222
46.338
77.853
1.00
24.10
7

ATOM
5102
CA
THR
A
939
93.271
46.998
78.625
1.00
24.89
6

ATOM
5103
CB
THR
A
939
92.972
46.915
80.135
1.00
24.82
6

ATOM
5104
OG1
THR
A
939
93.882
47.754
80.838
1.00
35.85
8

ATOM
5105
CG2
THR
A
939
93.147
45.525
80.636
1.00
21.76
6

ATOM
5106
C
THR
A
939
94.676
46.468
78.342
1.00
23.64
6

ATOM
5107
O
THR
A
939
95.647
47.219
78.397
1.00
20.70
8

ATOM
5108
N
PHE
A
940
94.793
45.175
78.058
1.00
23.55
7

ATOM
5109
CA
PHE
A
940
96.104
44.602
77.731
1.00
25.49
6

ATOM
5110
CB
PHE
A
940
95.999
43.084
77.543
1.00
26.06
6

ATOM
5111
CG
PHE
A
940
97.289
42.444
77.105
1.00
26.78
6

ATOM
5112
CD1
PHE
A
940
98.396
42.441
77.946
1.00
27.32
6

ATOM
5113
CD2
PHE
A
940
97.407
41.881
75.835
1.00
28.12
6

ATOM
5114
CE1
PHE
A
940
99.609
41.885
77.530
1.00
28.95
6

ATOM
5115
CE2
PHE
A
940
98.620
41.319
75.406
1.00
29.15
6

ATOM
5116
CZ
PHE
A
940
99.719
41.322
76.254
1.00
28.05
6

ATOM
5117
C
PHE
A
940
96.620
45.230
76.426
1.00
24.52
6

ATOM
5118
O
PHE
A
940
97.751
45.703
76.339
1.00
25.64
8

ATOM
5119
N
VAL
A
941
95.776
45.244
75.408
1.00
27.01
7

ATOM
5120
CA
VAL
A
941
96.177
45.815
74.130
1.00
26.56
6

ATOM
5121
CB
VAL
A
941
95.038
45.670
73.111
1.00
28.51
6

ATOM
5122
CG1
VAL
A
941
95.366
46.426
71.820
1.00
28.54
6

ATOM
5123
CG2
VAL
A
941
94.829
44.182
72.818
1.00
31.97
6

ATOM
5124
C
VAL
A
941
96.616
47.279
74.259
1.00
26.89
6

ATOM
5125
O
VAL
A
941
97.634
47.680
73.694
1.00
24.15
8

ATOM
5126
N
LEU
A
942
95.861
48.065
75.024
1.00
27.42
7

ATOM
5127
CA
LEU
A
942
96.169
49.478
75.223
1.00
26.63
6

ATOM
5128
CB
LEU
A
942
94.883
50.243
75.568
1.00
25.46
6

ATOM
5129
CG
LEU
A
942
93.817
50.260
74.465
1.00
27.81
6

ATOM
5130
CD1
LEU
A
942
92.543
50.887
74.971
1.00
26.84
6

ATOM
5131
CD2
LEU
A
942
94.353
51.023
73.257
1.00
27.22
6

ATOM
5132
C
LEU
A
942
97.234
49.723
76.295
1.00
27.43
6

ATOM
5133
O
LEU
A
942
97.536
50.866
76.626
1.00
25.94
8

ATOM
5134
N
GLY
A
943
97.795
48.650
76.842
1.00
28.17
7

ATOM
5135
CA
GLY
A
943
98.831
48.789
77.850
1.00
27.03
6

ATOM
5136
C
GLY
A
943
98.440
49.476
79.141
1.00
28.17
6

ATOM
5137
O
GLY
A
943
99.275
50.118
79.778
1.00
29.42
8

ATOM
5138
N
ILE
A
944
97.180
49.354
79.539
1.00
27.49
7

ATOM
5139
CA
ILE
A
944
96.725
49.975
80.781
1.00
28.15
6

ATOM
5140
CB
ILE
A
944
95.719
51.098
80.492
1.00
26.59
6

ATOM
5141
CG2
ILE
A
944
96.391
52.193
79.665
1.00
27.24
6

ATOM
5142
CG1
ILE
A
944
94.512
50.519
79.746
1.00
27.72
6

ATOM
5143
CD1
ILE
A
944
93.423
51.527
79.440
1.00
32.18
6

ATOM
5144
C
ILE
A
944
96.061
48.921
81.665
1.00
28.63
6

ATOM
5145
O
ILE
A
944
95.136
49.221
82.430
1.00
28.50
8

ATOM
5146
N
GLY
A
945
96.539
47.684
81.564
1.00
27.53
7

ATOM
5147
CA
GLY
A
945
95.949
46.610
82.345
1.00
28.27
6

ATOM
5148
C
GLY
A
945
96.313
46.506
83.819
1.00
28.76
6

ATOM
5149
O
GLY
A
945
95.500
46.029
84.618
1.00
27.40
8

ATOM
5150
N
ASP
A
946
97.514
46.946
84.187
1.00
28.53
7

ATOM
5151
CA
ASP
A
946
97.971
46.854
85.578
1.00
29.50
6

ATOM
5152
CB
ASP
A
946
99.494
46.939
85.649
1.00
31.27
6

ATOM
5153
CG
ASP
A
946
100.041
46.486
87.005
1.00
34.81
6

ATOM
5154
OD1
ASP
A
946
99.260
46.443
87.984
1.00
34.71
8

ATOM
5155
OD2
ASP
A
946
101.246
46.178
87.089
1.00
35.59
8

ATOM
5156
C
ASP
A
946
97.363
47.960
86.422
1.00
28.21
6

ATOM
5157
O
ASP
A
946
97.982
48.998
86.648
1.00
27.40
8

ATOM
5158
N
ARG
A
947
96.157
47.720
86.913
1.00
27.61
7

ATOM
5159
CA
ARG
A
947
95.461
48.728
87.689
1.00
29.78
6

ATOM
5160
CB
ARG
A
947
94.144
49.068
86.997
1.00
26.98
6

ATOM
5161
CG
ARG
A
947
94.367
49.525
85.561
1.00
28.90
6

ATOM
5162
CD
ARG
A
947
94.618
51.009
85.519
1.00
31.29
6

ATOM
5163
NE
ARG
A
947
93.460
51.673
84.941
1.00
37.62
7

ATOM
5164
CZ
ARG
A
947
92.921
52.789
85.400
1.00
36.41
6

ATOM
5165
NH1
ARG
A
947
93.429
53.399
86.467
1.00
38.13
7

ATOM
5166
NH2
ARG
A
947
91.864
53.316
84.787
1.00
38.45
7

ATOM
5167
C
ARG
A
947
95.177
48.354
89.130
1.00
30.77
6

ATOM
5168
O
ARG
A
947
95.160
47.184
89.520
1.00
28.88
8

ATOM
5169
N
HIS
A
948
94.950
49.389
89.909
1.00
32.18
7

ATOM
5170
CA
HIS
A
948
94.589
49.273
91.306
1.00
31.74
6

ATOM
5171
CB
HIS
A
948
95.075
50.495
92.036
1.00
35.02
6

ATOM
5172
CG
HIS
A
948
94.614
50.585
93.498
1.00
36.78
6

ATOM
5173
CD2
HIS
A
948
94.158
51.643
94.212
1.00
37.70
6

ATOM
5174
ND1
HIS
A
948
94.569
49.502
94.351
1.00
39.60
7

ATOM
5175
CE1
HIS
A
948
94.108
49.889
95.527
1.00
39.36
6

ATOM
5176
NE2
HIS
A
948
93.851
51.184
95.469
1.00
38.54
7

ATOM
5177
C
HIS
A
948
93.074
49.048
91.341
1.00
31.52
6

ATOM
5178
O
HIS
A
948
92.429
49.389
90.346
1.00
27.23
8

ATOM
5179
N
ASN
A
949
92.452
48.419
92.367
1.00
30.16
7

ATOM
5180
CA
ASN
A
949
90.982
48.203
92.275
1.00
33.49
6

ATOM
5181
CB
ASN
A
949
90.446
47.411
93.451
1.00
38.83
6

ATOM
5182
CG
ASN
A
949
91.528
46.611
94.111
1.00
43.48
6

ATOM
5183
OD1
ASN
A
949
92.686
46.626
93.676
1.00
49.10
8

ATOM
5184
ND2
ASN
A
949
91.172
45.884
95.167
1.00
41.84
7

ATOM
5185
C
ASN
A
949
90.380
49.565
92.219
1.00
32.97
6

ATOM
5186
O
ASN
A
949
89.976
50.064
91.162
1.00
33.92
8

ATOM
5187
N
ASP
A
950
90.326
50.180
93.386
1.00
31.20
7

ATOM
5188
CA
ASP
A
950
89.995
51.558
93.480
1.00
30.79
6

ATOM
5189
CB
ASP
A
950
91.310
52.295
93.797
1.00
34.28
6

ATOM
5190
CG
ASP
A
950
91.310
53.336
94.889
1.00
36.96
6

ATOM
5191
OD1
ASP
A
950
90.764
53.053
95.972
1.00
37.18
8

ATOM
5192
OD2
ASP
A
950
91.872
54.427
94.667
1.00
40.02
8

ATOM
5193
C
ASP
A
950
89.498
52.116
92.156
1.00
31.17
6

ATOM
5194
O
ASP
A
950
88.575
52.915
92.095
1.00
29.80
8

ATOM
5195
N
ASN
A
951
90.180
51.654
91.100
1.00
28.84
7

ATOM
5196
CA
ASN
A
951
89.994
52.083
89.699
1.00
27.59
6

ATOM
5197
CB
ASN
A
951
91.368
52.401
89.089
1.00
28.57
6

ATOM
5198
CG
ASN
A
951
92.155
53.424
89.867
1.00
30.95
6

ATOM
5199
OD1
ASN
A
951
93.365
53.283
90.057
1.00
29.91
8

ATOM
5200
ND2
ASN
A
951
91.472
54.462
90.333
1.00
28.90
7

ATOM
5201
C
ASN
A
951
89.252
51.093
88.791
1.00
26.53
6

ATOM
5202
O
ASN
A
951
89.335
51.165
87.560
1.00
25.92
8

ATOM
5203
N
ILE
A
952
88.546
50.155
89.411
1.00
25.51
7

ATOM
5204
CA
ILE
A
952
87.733
49.188
88.687
1.00
23.49
6

ATOM
5205
CB
ILE
A
952
88.358
47.779
88.698
1.00
25.21
6

ATOM
5206
CG2
ILE
A
952
87.443
46.791
87.963
1.00
22.97
6

ATOM
5207
CG1
ILE
A
952
89.736
47.818
88.042
1.00
24.01
6

ATOM
5208
CD1
ILE
A
952
90.411
46.466
87.985
1.00
24.49
6

ATOM
5209
C
ILE
A
952
86.389
49.106
89.386
1.00
24.39
6

ATOM
5210
O
ILE
A
952
86.326
48.954
90.611
1.00
23.34
8

ATOM
5211
N
MET
A
953
85.315
49.229
88.616
1.00
22.84
7

ATOM
5212
CA
MET
A
953
83.980
49.146
89.180
1.00
23.47
6

ATOM
5213
CB
MET
A
953
83.209
50.446
88.919
1.00
24.10
6

ATOM
5214
CG
MET
A
953
83.851
51.672
89.567
1.00
27.68
6

ATOM
5215
SD
MET
A
953
82.869
53.173
89.359
1.00
32.58
16

ATOM
5216
CE
MET
A
953
81.557
52.885
90.549
1.00
30.06
6

ATOM
5217
C
MET
A
953
83.195
47.958
88.639
1.00
24.00
6

ATOM
5218
O
MET
A
953
83.580
47.334
87.645
1.00
25.29
8

ATOM
5219
N
ILE
A
954
82.090
47.658
89.309
1.00
23.16
7

ATOM
5220
CA
ILE
A
954
81.206
46.563
88.939
1.00
23.63
6

ATOM
5221
CB
ILE
A
954
81.490
45.310
89.796
1.00
24.30
6

ATOM
5222
CG2
ILE
A
954
81.217
45.621
91.270
1.00
22.16
6

ATOM
5223
CG1
ILE
A
954
80.586
44.146
89.374
1.00
27.74
6

ATOM
5224
CD1
ILE
A
954
80.781
43.691
87.966
1.00
33.57
6

ATOM
5225
C
ILE
A
954
79.792
47.036
89.224
1.00
24.45
6

ATOM
5226
O
ILE
A
954
79.550
47.700
90.228
1.00
26.39
8

ATOM
5227
N
THR
A
955
78.860
46.714
88.339
1.00
24.02
7

ATOM
5228
CA
THR
A
955
77.485
47.100
88.552
1.00
26.11
6

ATOM
5229
CB
THR
A
955
76.735
47.319
87.224
1.00
28.11
6

ATOM
5230
OG1
THR
A
955
76.639
46.070
86.523
1.00
25.35
8

ATOM
5231
CG2
THR
A
955
77.464
48.357
86.366
1.00
23.16
6

ATOM
5232
C
THR
A
955
76.792
45.978
89.310
1.00
27.93
6

ATOM
5233
O
THR
A
955
77.271
44.842
89.345
1.00
26.88
8

ATOM
5234
N
GLU
A
956
75.662
46.299
89.921
1.00
28.76
7

ATOM
5235
CA
GLU
A
956
74.937
45.295
90.665
1.00
31.90
6

ATOM
5236
CB
GLU
A
956
73.803
45.944
91.455
1.00
33.98
6

ATOM
5237
CG
GLU
A
956
74.250
47.245
92.126
1.00
36.40
6

ATOM
5238
CD
GLU
A
956
73.114
47.977
92.803
1.00
38.59
6

ATOM
5239
OE1
GLU
A
956
72.188
47.300
93.297
1.00
40.22
8

ATOM
5240
OE2
GLU
A
956
73.153
49.226
92.850
1.00
40.59
8

ATOM
5241
C
GLU
A
956
74.422
44.233
89.720
1.00
32.86
6

ATOM
5242
O
GLU
A
956
74.083
43.139
90.149
1.00
32.13
8

ATOM
5243
N
THR
A
957
74.380
44.547
88.427
1.00
31.31
7

ATOM
5244
CA
THR
A
957
73.932
43.564
87.456
1.00
32.42
6

ATOM
5245
CB
THR
A
957
73.203
44.223
86.286
1.00
33.93
6

ATOM
5246
OG1
THR
A
957
74.097
45.107
85.598
1.00
40.17
8

ATOM
5247
CG2
THR
A
957
71.995
45.001
86.784
1.00
32.42
6

ATOM
5248
C
THR
A
957
75.106
42.753
86.938
1.00
31.82
6

ATOM
5249
O
THR
A
957
74.982
42.011
85.959
1.00
33.39
8

ATOM
5250
N
GLY
A
958
76.262
42.898
87.585
1.00
30.12
7

ATOM
5251
CA
GLY
A
958
77.442
42.131
87.219
1.00
28.78
6

ATOM
5252
C
GLY
A
958
78.403
42.666
86.175
1.00
28.21
6

ATOM
5253
O
GLY
A
958
79.419
42.032
85.894
1.00
27.30
8

ATOM
5254
N
ASN
A
959
78.112
43.830
85.607
1.00
26.26
7

ATOM
5255
CA
ASN
A
959
78.982
44.390
84.577
1.00
24.88
6

ATOM
5256
CB
ASN
A
959
78.218
45.436
83.761
1.00
25.27
6

ATOM
5257
CG
ASN
A
959
78.691
45.514
82.329
1.00
27.14
6

ATOM
5258
OD1
ASN
A
959
79.889
45.609
82.054
1.00
28.62
8

ATOM
5259
ND2
ASN
A
959
77.744
45.473
81.401
1.00
25.02
7

ATOM
5260
C
ASN
A
959
80.248
45.037
85.128
1.00
23.70
6

ATOM
5261
O
ASN
A
959
80.188
46.082
85.784
1.00
22.39
8

ATOM
5262
N
LEU
A
960
81.397
44.429
84.867
1.00
23.25
7

ATOM
5263
CA
LEU
A
960
82.650
45.020
85.324
1.00
25.46
6

ATOM
5264
CB
LEU
A
960
83.747
43.970
85.393
1.00
27.15
6

ATOM
5265
CG
LEU
A
960
85.042
44.526
85.977
1.00
28.10
6

ATOM
5266
CD1
LEU
A
960
85.569
43.564
87.020
1.00
30.12
6

ATOM
5267
CD2
LEU
A
960
86.060
44.759
84.874
1.00
29.30
6

ATOM
5268
C
LEU
A
960
83.086
46.128
84.358
1.00
25.45
6

ATOM
5269
O
LEU
A
960
82.721
46.104
83.187
1.00
27.12
8

ATOM
5270
N
PHE
A
961
83.838
47.105
84.853
1.00
22.85
7

ATOM
5271
CA
PHE
A
961
84.342
48.178
84.008
1.00
23.55
6

ATOM
5272
CB
PHE
A
961
83.192
49.057
83.484
1.00
23.57
6

ATOM
5273
CG
PHE
A
961
82.620
50.019
84.497
1.00
26.43
6

ATOM
5274
CD1
PHE
A
961
82.944
51.367
84.452
1.00
24.70
6

ATOM
5275
CD2
PHE
A
961
81.702
49.587
85.451
1.00
26.34
6

ATOM
5276
CE1
PHE
A
961
82.356
52.279
85.338
1.00
28.62
6

ATOM
5277
CE2
PHE
A
961
81.110
50.482
86.338
1.00
28.56
6

ATOM
5278
CZ
PHE
A
961
81.433
51.836
86.283
1.00
28.26
6

ATOM
5279
C
PHE
A
961
85.402
49.026
84.707
1.00
23.47
6

ATOM
5280
O
PHE
A
961
85.288
49.323
85.899
1.00
24.79
8

ATOM
5281
N
HIS
A
962
86.450
49.373
83.958
1.00
22.83
7

ATOM
5282
CA
HIS
A
962
87.551
50.184
84.463
1.00
22.12
6

ATOM
5283
CB
HIS
A
962
88.796
49.976
83.611
1.00
22.89
6

ATOM
5284
CG
HIS
A
962
89.489
48.627
83.912
1.00
22.12
6

ATOM
5285
CD2
HIS
A
962
88.976
47.393
84.136
1.00
25.81
6

ATOM
5286
ND1
HIS
A
962
90.857
48.493
84.004
1.00
22.00
7

ATOM
5287
CE1
HIS
A
962
91.161
47.235
84.278
1.00
23.56
6

ATOM
5288
NE2
HIS
A
962
90.038
46.545
84.363
1.00
22.35
7

ATOM
5289
C
HIS
A
962
87.203
51.666
84.411
1.00
23.07
6

ATOM
5290
O
HIS
A
962
86.367
52.086
83.611
1.00
22.28
8

ATOM
5291
N
ILE
A
963
87.847
52.459
85.265
1.00
21.24
7

ATOM
5292
CA
ILE
A
963
87.626
53.900
85.291
1.00
23.70
6

ATOM
5293
CB
ILE
A
963
86.638
54.307
86.416
1.00
24.96
6

ATOM
5294
CG2
ILE
A
963
85.259
53.710
86.179
1.00
21.54
6

ATOM
5295
CG1
ILE
A
963
87.167
53.893
87.791
1.00
24.91
6

ATOM
5296
CD1
ILE
A
963
86.501
54.624
88.939
1.00
25.79
6

ATOM
5297
C
ILE
A
963
88.909
54.665
85.588
1.00
23.18
6

ATOM
5298
O
ILE
A
963
89.953
54.077
85.819
1.00
22.10
8

ATOM
5299
N
ASP
A
964
88.772
56.003
85.584
1.00
27.31
7

ATOM
5300
CA
ASP
A
964
89.853
56.909
85.984
1.00
28.48
6

ATOM
5301
CB
ASP
A
964
90.107
56.672
87.461
1.00
31.30
6

ATOM
5302
CG
ASP
A
964
90.800
57.808
88.169
1.00
39.52
6

ATOM
5303
OD1
ASP
A
964
90.921
57.735
89.402
1.00
37.68
8

ATOM
5304
OD2
ASP
A
964
91.232
58.777
87.499
1.00
45.25
8

ATOM
5305
C
ASP
A
964
91.166
56.724
85.169
1.00
29.96
6

ATOM
5306
O
ASP
A
964
92.262
56.615
85.722
1.00
26.26
8

ATOM
5307
N
PHE
A
965
91.068
56.618
83.848
1.00
30.89
7

ATOM
5308
CA
PHE
A
965
92.185
56.271
82.960
1.00
33.06
6

ATOM
5309
CB
PHE
A
965
91.681
56.169
81.534
1.00
30.23
6

ATOM
5310
CG
PHE
A
965
90.696
55.103
81.433
1.00
27.01
6

ATOM
5311
CD1
PHE
A
965
89.342
55.395
81.356
1.00
24.78
6

ATOM
5312
CD2
PHE
A
965
91.090
53.774
81.478
1.00
24.52
6

ATOM
5313
CE1
PHE
A
965
88.396
54.384
81.325
1.00
25.44
6

ATOM
5314
CE2
PHE
A
965
90.154
52.760
81.480
1.00
23.93
6

ATOM
5315
CZ
PHE
A
965
88.801
53.063
81.404
1.00
23.17
6

ATOM
5316
C
PHE
A
965
93.395
57.182
82.825
1.00
36.41
6

ATOM
5317
O
PHE
A
965
93.551
57.744
81.734
1.00
35.82
8

ATOM
5318
N
GLY
A
966
94.278
57.381
83.786
1.00
107.63
7

ATOM
5319
CA
GLY
A
966
95.331
58.319
83.442
1.00
110.99
6

ATOM
5320
C
GLY
A
966
96.660
57.683
83.015
1.00
113.94
6

ATOM
5321
O
GLY
A
966
97.690
57.996
83.627
1.00
113.72
8

ATOM
5322
N
HIS
A
967
96.743
56.793
81.998
1.00
97.03
7

ATOM
5323
CA
HIS
A
967
98.114
56.229
81.722
1.00
99.97
6

ATOM
5324
CB
HIS
A
967
98.545
55.427
83.005
1.00
113.91
6

ATOM
5325
CG
HIS
A
967
99.053
53.936
82.957
1.00
115.45
6

ATOM
5326
CD2
HIS
A
967
99.316
53.103
81.919
1.00
117.36
6

ATOM
5327
ND1
HIS
A
967
99.340
53.158
84.093
1.00
116.31
7

ATOM
5328
CE1
HIS
A
967
99.765
51.949
83.722
1.00
117.98
6

ATOM
5329
NE2
HIS
A
967
99.769
51.901
82.409
1.00
118.42
7

ATOM
5330
C
HIS
A
967
98.391
55.365
80.474
1.00
100.39
6

ATOM
5331
O
HIS
A
967
97.769
54.304
80.302
1.00
101.31
8

ATOM
5332
N
ALA
A
968
99.327
55.793
79.601
1.00
66.10
7

ATOM
5333
CA
ALA
A
968
99.726
55.044
78.402
1.00
65.86
6

ATOM
5334
CB
ALA
A
968
100.403
53.739
78.809
1.00
56.44
6

ATOM
5335
C
ALA
A
968
98.546
54.746
77.487
1.00
66.34
6

ATOM
5336
O
ALA
A
968
98.143
55.583
76.684
1.00
65.65
8

ATOM
5337
N
GLU
A
981
106.981
44.356
90.596
1.00
51.73
7

ATOM
5338
CA
GLU
A
981
106.190
43.301
89.974
1.00
51.07
6

ATOM
5339
CB
GLU
A
981
105.736
42.290
91.025
1.00
52.96
6

ATOM
5340
CG
GLU
A
981
106.888
41.529
91.657
1.00
56.80
6

ATOM
5341
CD
GLU
A
981
106.422
40.348
92.478
1.00
58.68
6

ATOM
5342
OE1
GLU
A
981
105.840
40.564
93.565
1.00
60.29
8

ATOM
5343
OE2
GLU
A
981
106.633
39.202
92.028
1.00
60.44
8

ATOM
5344
C
GLU
A
981
104.981
43.874
89.248
1.00
49.92
6

ATOM
5345
O
GLU
A
981
104.390
44.862
89.693
1.00
47.26
8

ATOM
5346
N
ARG
A
982
104.614
43.244
88.133
1.00
48.49
7

ATOM
5347
CA
ARG
A
982
103.491
43.707
87.329
1.00
47.50
6

ATOM
5348
CB
ARG
A
982
104.020
44.527
86.146
1.00
50.63
6

ATOM
5349
CG
ARG
A
982
105.060
45.580
86.539
1.00
55.18
6

ATOM
5350
CD
ARG
A
982
104.468
46.660
87.449
1.00
59.70
6

ATOM
5351
NE
ARG
A
982
105.321
46.966
88.602
1.00
62.10
7

ATOM
5352
CZ
ARG
A
982
106.507
47.564
88.535
1.00
63.24
6

ATOM
5353
NH1
ARG
A
982
107.007
47.938
87.363
1.00
64.19
7

ATOM
5354
NH2
ARG
A
982
107.194
47.788
89.646
1.00
62.79
7

ATOM
5355
C
ARG
A
982
102.608
42.567
86.820
1.00
44.65
6

ATOM
5356
O
ARG
A
982
102.935
41.388
86.971
1.00
42.55
8

ATOM
5357
N
VAL
A
983
101.454
42.967
86.216
1.00
41.69
7

ATOM
5358
CA
VAL
A
983
100.438
42.036
85.649
1.00
40.15
6

ATOM
5359
CB
VAL
A
983
99.361
41.743
86.711
1.00
41.03
6

ATOM
5360
CG1
VAL
A
983
98.375
42.900
86.794
1.00
39.85
6

ATOM
5361
CG2
VAL
A
983
98.640
40.439
86.394
1.00
42.54
6

ATOM
5362
C
VAL
A
983
99.798
42.504
84.320
1.00
39.78
6

ATOM
5363
O
VAL
A
983
99.600
43.694
84.094
1.00
40.12
8

ATOM
5364
N
PRO
A
984
99.457
41.535
83.412
1.00
37.60
7

ATOM
5365
CD
PRO
A
984
100.350
40.406
83.113
1.00
36.05
6

ATOM
5366
CA
PRO
A
984
98.876
41.926
82.083
1.00
35.74
6

ATOM
5367
CB
PRO
A
984
98.634
40.603
81.392
1.00
35.60
6

ATOM
5368
CG
PRO
A
984
99.837
39.828
81.807
1.00
34.93
6

ATOM
5369
C
PRO
A
984
97.737
42.854
82.187
1.00
34.88
6

ATOM
5370
O
PRO
A
984
97.627
43.910
81.566
1.00
36.00
8

ATOM
5371
N
PHE
A
985
96.918
42.341
83.055
1.00
32.49
7

ATOM
5372
CA
PHE
A
985
95.662
42.895
83.390
1.00
29.82
6

ATOM
5373
CB
PHE
A
985
94.681
42.484
82.312
1.00
29.88
6

ATOM
5374
CG
PHE
A
985
94.814
41.046
81.834
1.00
30.38
6

ATOM
5375
CD1
PHE
A
985
94.274
40.004
82.592
1.00
30.15
6

ATOM
5376
CD2
PHE
A
985
95.433
40.743
80.627
1.00
28.89
6

ATOM
5377
CE1
PHE
A
985
94.342
38.687
82.148
1.00
27.99
6

ATOM
5378
CE2
PHE
A
985
95.505
39.429
80.174
1.00
27.92
6

ATOM
5379
CZ
PHE
A
985
94.957
38.400
80.936
1.00
28.92
6

ATOM
5380
C
PHE
A
985
95.190
42.418
84.752
1.00
29.59
6

ATOM
5381
O
PHE
A
985
95.902
41.682
85.430
1.00
28.68
8

ATOM
5382
N
VAL
A
986
93.999
42.841
85.153
1.00
28.98
7

ATOM
5383
CA
VAL
A
986
93.469
42.474
86.451
1.00
27.73
6

ATOM
5384
CB
VAL
A
986
92.747
43.685
87.110
1.00
28.45
6

ATOM
5385
CG1
VAL
A
986
92.163
43.290
88.440
1.00
26.12
6

ATOM
5386
CG2
VAL
A
986
93.739
44.840
87.309
1.00
26.19
6

ATOM
5387
C
VAL
A
986
92.525
41.283
86.392
1.00
27.39
6

ATOM
5388
O
VAL
A
986
91.444
41.342
85.801
1.00
25.78
8

ATOM
5389
N
LEU
A
987
92.994
40.194
86.947
1.00
27.03
7

ATOM
5390
CA
LEU
A
987
92.285
38.956
87.027
1.00
28.50
6

ATOM
5391
CB
LEU
A
987
92.546
38.000
85.853
1.00
28.17
6

ATOM
5392
CG
LEU
A
987
91.821
36.661
85.899
1.00
27.63
6

ATOM
5393
CD1
LEU
A
987
90.311
36.877
85.877
1.00
26.65
6

ATOM
5394
CD2
LEU
A
987
92.271
35.769
84.751
1.00
28.75
6

ATOM
5395
C
LEU
A
987
92.779
38.404
88.314
1.00
28.89
6

ATOM
5396
O
LEU
A
987
93.756
37.676
88.401
1.00
24.90
8

ATOM
5397
N
THR
A
988
92.044
38.812
89.286
1.00
29.15
7

ATOM
5398
CA
THR
A
988
92.328
38.537
90.656
1.00
30.49
6

ATOM
5399
CB
THR
A
988
92.109
39.839
91.437
1.00
31.85
6

ATOM
5400
OG1
THR
A
988
90.739
40.231
91.367
1.00
31.86
8

ATOM
5401
CG2
THR
A
988
92.980
40.949
90.867
1.00
29.36
6

ATOM
5402
C
THR
A
988
91.491
37.352
91.173
1.00
30.12
6

ATOM
5403
O
THR
A
988
90.573
36.943
90.473
1.00
31.64
8

ATOM
5404
N
PRO
A
989
91.758
36.755
92.382
1.00
30.28
7

ATOM
5405
CD
PRO
A
989
93.103
36.370
92.819
1.00
28.64
6

ATOM
5406
CA
PRO
A
989
90.884
35.622
92.794
1.00
29.52
6

ATOM
5407
CB
PRO
A
989
91.437
35.219
94.158
1.00
30.96
6

ATOM
5408
CG
PRO
A
989
92.906
35.390
93.941
1.00
30.67
6

ATOM
5409
C
PRO
A
989
89.452
35.994
92.700
1.00
30.20
6

ATOM
5410
O
PRO
A
989
88.657
35.541
91.878
1.00
30.77
8

ATOM
5411
N
ASP
A
990
89.172
36.878
93.635
1.00
28.71
7

ATOM
5412
CA
ASP
A
990
87.847
37.350
93.806
1.00
29.74
6

ATOM
5413
CB
ASP
A
990
87.815
38.751
94.474
1.00
31.90
6

ATOM
5414
CG
ASP
A
990
88.553
39.857
93.741
1.00
35.47
6

ATOM
5415
OD1
ASP
A
990
89.679
39.608
93.252
1.00
35.69
8

ATOM
5416
OD2
ASP
A
990
88.016
40.986
93.644
1.00
37.34
8

ATOM
5417
C
ASP
A
990
87.145
37.300
92.469
1.00
30.20
6

ATOM
5418
O
ASP
A
990
85.984
36.910
92.415
1.00
29.80
8

ATOM
5419
N
PHE
A
991
87.821
37.696
91.384
1.00
30.30
7

ATOM
5420
CA
PHE
A
991
87.150
37.632
90.077
1.00
30.73
6

ATOM
5421
CB
PHE
A
991
87.990
38.332
88.988
1.00
29.28
6

ATOM
5422
CG
PHE
A
991
88.046
39.845
89.107
1.00
29.74
6

ATOM
5423
CD1
PHE
A
991
87.586
40.499
90.245
1.00
29.62
6

ATOM
5424
CD2
PHE
A
991
88.611
40.608
88.084
1.00
29.23
6

ATOM
5425
CE1
PHE
A
991
87.693
41.899
90.367
1.00
29.60
6

ATOM
5426
CE2
PHE
A
991
88.724
42.000
88.196
1.00
28.44
6

ATOM
5427
CZ
PHE
A
991
88.266
42.644
89.338
1.00
26.82
6

ATOM
5428
C
PHE
A
991
86.987
36.149
89.712
1.00
30.46
6

ATOM
5429
O
PHE
A
991
85.912
35.702
89.295
1.00
30.48
8

ATOM
5430
N
LEU
A
992
88.068
35.397
89.878
1.00
29.93
7

ATOM
5431
CA
LEU
A
992
88.070
33.971
89.579
1.00
31.60
6

ATOM
5432
CB
LEU
A
992
89.454
33.388
89.864
1.00
29.72
6

ATOM
5433
CG
LEU
A
992
90.612
34.226
89.321
1.00
31.61
6

ATOM
5434
CD1
LEU
A
992
91.953
33.721
89.871
1.00
30.33
6

ATOM
5435
CD2
LEU
A
992
90.586
34.170
87.801
1.00
32.06
6

ATOM
5436
C
LEU
A
992
87.005
33.228
90.383
1.00
32.29
6

ATOM
5437
O
LEU
A
992
86.279
32.383
89.841
1.00
32.10
8

ATOM
5438
N
PHE
A
993
86.903
33.550
91.670
1.00
33.79
7

ATOM
5439
CA
PHE
A
993
85.916
32.917
92.537
1.00
35.79
6

ATOM
5440
CB
PHE
A
993
85.944
33.547
93.933
1.00
39.33
6

ATOM
5441
CG
PHE
A
993
85.098
32.821
94.938
1.00
42.22
6

ATOM
5442
CD1
PHE
A
993
85.622
31.763
95.673
1.00
44.43
6

ATOM
5443
CD2
PHE
A
993
83.764
33.172
95.127
1.00
44.41
6

ATOM
5444
CE1
PHE
A
993
84.832
31.060
96.580
1.00
45.21
6

ATOM
5445
CE2
PHE
A
993
82.962
32.478
96.031
1.00
45.86
6

ATOM
5446
CZ
PHE
A
993
83.498
31.419
96.760
1.00
46.64
6

ATOM
5447
C
PHE
A
993
84.520
33.071
91.937
1.00
36.11
6

ATOM
5448
O
PHE
A
993
83.724
32.134
91.954
1.00
35.03
8

ATOM
5449
N
VAL
A
994
84.216
34.258
91.415
1.00
37.13
7

ATOM
5450
CA
VAL
A
994
82.911
34.492
90.800
1.00
36.74
6

ATOM
5451
CB
VAL
A
994
82.799
35.939
90.257
1.00
37.53
6

ATOM
5452
CG1
VAL
A
994
81.477
36.125
89.518
1.00
36.82
6

ATOM
5453
CG2
VAL
A
994
82.909
36.940
91.407
1.00
36.38
6

ATOM
5454
C
VAL
A
994
82.730
33.505
89.638
1.00
38.92
6

ATOM
5455
O
VAL
A
994
81.618
33.045
89.350
1.00
37.08
8

ATOM
5456
N
MET
A
995
83.837
33.174
88.985
1.00
38.83
7

ATOM
5457
CA
MET
A
995
83.809
32.260
87.857
1.00
41.43
6

ATOM
5458
CB
MET
A
995
85.029
32.507
86.965
1.00
42.16
6

ATOM
5459
CG
MET
A
995
85.166
33.961
86.527
1.00
43.41
6

ATOM
5460
SD
MET
A
995
86.420
34.258
85.261
1.00
43.84
16

ATOM
5461
CE
MET
A
995
86.677
35.969
85.522
1.00
44.97
6

ATOM
5462
C
MET
A
995
83.771
30.807
88.330
1.00
43.41
6

ATOM
5463
O
MET
A
995
83.724
29.881
87.517
1.00
42.52
8

ATOM
5464
N
GLY
A
996
83.795
30.622
89.648
1.00
45.12
7

ATOM
5465
CA
GLY
A
996
83.742
29.288
90.220
1.00
47.36
6

ATOM
5466
C
GLY
A
996
85.049
28.520
90.346
1.00
48.76
6

ATOM
5467
O
GLY
A
996
85.028
27.329
90.651
1.00
47.76
8

ATOM
5468
N
THR
A
997
86.183
29.180
90.090
1.00
50.76
7

ATOM
5469
CA
THR
A
997
87.449
28.485
90.189
1.00
54.25
6

ATOM
5470
CB
THR
A
997
88.256
28.609
88.881
1.00
56.50
6

ATOM
5471
OG1
THR
A
997
87.492
28.089
87.791
1.00
57.73
8

ATOM
5472
CG2
THR
A
997
89.562
27.828
88.994
1.00
57.63
6

ATOM
5473
C
THR
A
997
88.239
29.077
91.357
1.00
55.25
6

ATOM
5474
O
THR
A
997
88.057
30.257
91.703
1.00
54.96
8

ATOM
5475
N
SER
A
998
89.122
28.292
91.983
1.00
56.94
7

ATOM
5476
CA
SER
A
998
89.936
28.788
93.107
1.00
59.15
6

ATOM
5477
CB
SER
A
998
89.086
28.798
94.367
1.00
59.32
6

ATOM
5478
OG
SER
A
998
89.552
27.839
95.300
1.00
62.07
8

ATOM
5479
C
SER
A
998
91.251
28.051
93.390
1.00
60.57
6

ATOM
5480
O
SER
A
998
91.289
27.196
94.256
1.00
60.99
8

ATOM
5481
N
GLY
A
999
92.339
28.363
92.677
1.00
62.22
7

ATOM
5482
CA
GLY
A
999
93.618
27.713
92.953
1.00
65.00
6

ATOM
5483
C
GLY
A
999
94.409
27.491
91.690
1.00
66.89
6

ATOM
5484
O
GLY
A
999
95.339
28.219
91.372
1.00
67.58
8

ATOM
5485
N
LYS
A
1000
94.023
26.483
90.987
1.00
68.03
7

ATOM
5486
CA
LYS
A
1000
94.580
26.107
89.703
1.00
69.47
6

ATOM
5487
CB
LYS
A
1000
96.064
25.757
89.715
1.00
70.59
6

ATOM
5488
CG
LYS
A
1000
96.852
26.670
88.776
1.00
72.51
6

ATOM
5489
CD
LYS
A
1000
97.217
27.978
89.460
1.00
73.37
6

ATOM
5490
CE
LYS
A
1000
98.437
27.843
90.369
1.00
73.29
6

ATOM
5491
NZ
LYS
A
1000
98.839
29.158
90.941
1.00
73.66
7

ATOM
5492
C
LYS
A
1000
93.727
24.976
89.327
1.00
69.25
6

ATOM
5493
O
LYS
A
1000
94.072
23.803
89.293
1.00
69.64
8

ATOM
5494
N
LYS
A
1001
92.558
25.460
89.064
1.00
68.55
7

ATOM
5495
CA
LYS
A
1001
91.522
24.594
88.754
1.00
66.95
6

ATOM
5496
CB
LYS
A
1001
90.386
24.753
89.757
1.00
68.10
6

ATOM
5497
CG
LYS
A
1001
90.376
23.694
90.849
1.00
68.79
6

ATOM
5498
CD
LYS
A
1001
89.669
24.195
92.078
1.00
69.91
6

ATOM
5499
CE
LYS
A
1001
88.358
23.464
92.292
1.00
70.18
6

ATOM
5500
NZ
LYS
A
1001
87.172
24.289
91.911
1.00
71.09
7

ATOM
5501
C
LYS
A
1001
90.978
24.835
87.410
1.00
65.00
6

ATOM
5502
O
LYS
A
1001
91.648
24.920
86.397
1.00
65.19
8

ATOM
5503
N
THR
A
1002
89.742
24.924
87.533
1.00
61.66
7

ATOM
5504
CA
THR
A
1002
88.963
25.026
86.313
1.00
58.39
6

ATOM
5505
CB
THR
A
1002
89.279
23.873
85.360
1.00
59.54
6

ATOM
5506
OG1
THR
A
1002
88.620
24.089
84.107
1.00
61.24
8

ATOM
5507
CG2
THR
A
1002
88.827
22.549
85.957
1.00
59.77
6

ATOM
5508
C
THR
A
1002
87.473
25.058
86.621
1.00
55.30
6

ATOM
5509
O
THR
A
1002
87.054
24.718
87.720
1.00
56.42
8

ATOM
5510
N
SER
A
1003
86.710
25.446
85.613
1.00
51.09
7

ATOM
5511
CA
SER
A
1003
85.259
25.549
85.711
1.00
47.82
6

ATOM
5512
CB
SER
A
1003
84.875
26.558
86.798
1.00
47.37
6

ATOM
5513
OG
SER
A
1003
85.305
27.867
86.461
1.00
46.63
8

ATOM
5514
C
SER
A
1003
84.630
25.956
84.383
1.00
45.58
6

ATOM
5515
O
SER
A
1003
85.284
26.523
83.499
1.00
45.11
8

ATOM
5516
N
PRO
A
1004
83.343
25.665
84.250
1.00
43.39
7

ATOM
5517
CD
PRO
A
1004
82.843
24.326
84.630
1.00
42.06
6

ATOM
5518
CA
PRO
A
1004
82.622
26.063
83.021
1.00
41.41
6

ATOM
5519
CB
PRO
A
1004
81.231
25.525
83.256
1.00
42.02
6

ATOM
5520
CG
PRO
A
1004
81.513
24.214
83.950
1.00
43.96
6

ATOM
5521
C
PRO
A
1004
82.823
27.500
82.661
1.00
39.11
6

ATOM
5522
O
PRO
A
1004
83.103
27.858
81.530
1.00
37.60
8

ATOM
5523
N
HIS
A
1005
82.659
28.333
83.682
1.00
36.78
7

ATOM
5524
CA
HIS
A
1005
82.765
29.783
83.518
1.00
35.56
6

ATOM
5525
CB
HIS
A
1005
82.297
30.488
84.781
1.00
35.67
6

ATOM
5526
CG
HIS
A
1005
80.782
30.503
84.977
1.00
36.24
6

ATOM
5527
CD2
HIS
A
1005
80.029
30.210
86.064
1.00
38.39
6

ATOM
5528
ND1
HIS
A
1005
79.896
30.842
83.978
1.00
40.10
7

ATOM
5529
CE1
HIS
A
1005
78.660
30.761
84.440
1.00
39.67
6

ATOM
5530
NE2
HIS
A
1005
78.714
30.379
85.704
1.00
38.79
7

ATOM
5531
C
HIS
A
1005
84.156
30.221
83.183
1.00
34.58
6

ATOM
5532
O
HIS
A
1005
84.359
31.059
82.298
1.00
34.62
8

ATOM
5533
N
PHE
A
1006
85.146
29.669
83.880
1.00
31.65
7

ATOM
5534
CA
PHE
A
1006
86.520
30.054
83.592
1.00
32.27
6

ATOM
5535
CB
PHE
A
1006
87.509
29.389
84.552
1.00
35.31
6

ATOM
5536
CG
PHE
A
1006
88.944
29.747
84.272
1.00
37.62
6

ATOM
5537
CD1
PHE
A
1006
89.382
31.067
84.392
1.00
39.64
6

ATOM
5538
CD2
PHE
A
1006
89.855
28.772
83.870
1.00
39.21
6

ATOM
5539
CE1
PHE
A
1006
90.708
31.411
84.116
1.00
41.57
6

ATOM
5540
CE2
PHE
A
1006
91.182
29.099
83.590
1.00
38.36
6

ATOM
5541
CZ
PHE
A
1006
91.612
30.423
83.713
1.00
42.11
6

ATOM
5542
C
PHE
A
1006
86.867
29.666
82.164
1.00
32.65
6

ATOM
5543
O
PHE
A
1006
87.412
30.474
81.408
1.00
32.41
8

ATOM
5544
N
GLN
A
1007
86.556
28.424
81.792
1.00
31.71
7

ATOM
5545
CA
GLN
A
1007
86.827
27.973
80.437
1.00
32.34
6

ATOM
5546
CB
GLN
A
1007
86.365
26.520
80.252
1.00
34.57
6

ATOM
5547
CG
GLN
A
1007
87.107
25.525
81.128
1.00
38.89
6

ATOM
5548
CD
GLN
A
1007
86.848
24.079
80.727
1.00
42.63
6

ATOM
5549
OE1
GLN
A
1007
87.362
23.157
81.353
1.00
44.52
8

ATOM
5550
NE2
GLN
A
1007
86.054
23.880
79.673
1.00
43.10
7

ATOM
5551
C
GLN
A
1007
86.082
28.895
79.473
1.00
31.52
6

ATOM
5552
O
GLN
A
1007
86.581
29.220
78.399
1.00
30.63
8

ATOM
5553
N
LYS
A
1008
84.883
29.310
79.870
1.00
31.06
7

ATOM
5554
CA
LYS
A
1008
84.069
30.212
79.063
1.00
34.13
6

ATOM
5555
CB
LYS
A
1008
82.720
30.444
79.746
1.00
38.12
6

ATOM
5556
CG
LYS
A
1008
81.648
31.032
78.844
1.00
40.26
6

ATOM
5557
CD
LYS
A
1008
81.115
29.980
77.874
1.00
45.72
6

ATOM
5558
CE
LYS
A
1008
80.132
30.587
76.878
1.00
47.20
6

ATOM
5559
NZ
LYS
A
1008
79.501
29.563
75.995
1.00
48.34
7

ATOM
5560
C
LYS
A
1008
84.825
31.545
78.935
1.00
34.43
6

ATOM
5561
O
LYS
A
1008
84.821
32.177
77.873
1.00
32.44
8

ATOM
5562
N
PHE
A
1009
85.470
31.946
80.034
1.00
34.13
7

ATOM
5563
CA
PHE
A
1009
86.267
33.176
80.118
1.00
33.89
6

ATOM
5564
CB
PHE
A
1009
86.822
33.340
81.544
1.00
31.07
6

ATOM
5565
CG
PHE
A
1009
87.740
34.532
81.722
1.00
30.14
6

ATOM
5566
CD1
PHE
A
1009
87.222
35.822
81.852
1.00
28.75
6

ATOM
5567
CD2
PHE
A
1009
89.117
34.363
81.752
1.00
28.08
6

ATOM
5568
CE1
PHE
A
1009
88.062
36.921
82.008
1.00
25.93
6

ATOM
5569
CE2
PHE
A
1009
89.969
35.454
81.903
1.00
31.08
6

ATOM
5570
CZ
PHE
A
1009
89.434
36.741
82.032
1.00
30.47
6

ATOM
5571
C
PHE
A
1009
87.435
33.094
79.137
1.00
34.58
6

ATOM
5572
O
PHE
A
1009
87.664
34.007
78.342
1.00
34.74
8

ATOM
5573
N
GLN
A
1010
88.167
31.988
79.203
1.00
33.16
7

ATOM
5574
CA
GLN
A
1010
89.323
31.781
78.334
1.00
34.46
6

ATOM
5575
CB
GLN
A
1010
89.992
30.442
78.640
1.00
33.69
6

ATOM
5576
CG
GLN
A
1010
90.641
30.340
80.006
1.00
32.51
6

ATOM
5577
CD
GLN
A
1010
91.186
28.941
80.259
1.00
34.76
6

ATOM
5578
OE1
GLN
A
1010
90.440
27.957
80.209
1.00
32.39
8

ATOM
5579
NE2
GLN
A
1010
92.486
28.845
80.527
1.00
34.26
7

ATOM
5580
C
GLN
A
1010
88.967
31.813
76.858
1.00
33.02
6

ATOM
5581
O
GLN
A
1010
89.718
32.352
76.053
1.00
35.02
8

ATOM
5582
N
ASP
A
1011
87.826
31.226
76.511
1.00
33.84
7

ATOM
5583
CA
ASP
A
1011
87.369
31.164
75.122
1.00
33.16
6

ATOM
5584
CB
ASP
A
1011
86.195
30.192
75.003
1.00
35.01
6

ATOM
5585
CG
ASP
A
1011
85.730
30.015
73.566
1.00
37.85
6

ATOM
5586
OD1
ASP
A
1011
86.599
29.877
72.680
1.00
41.16
8

ATOM
5587
OD2
ASP
A
1011
84.506
30.001
73.322
1.00
40.48
8

ATOM
5588
C
ASP
A
1011
86.955
32.531
74.573
1.00
32.70
6

ATOM
5589
O
ASP
A
1011
87.262
32.880
73.429
1.00
30.83
8

ATOM
5590
N
ILE
A
1012
86.226
33.287
75.384
1.00
30.48
7

ATOM
5591
CA
ILE
A
1012
85.793
34.622
74.995
1.00
30.39
6

ATOM
5592
CB
ILE
A
1012
84.890
35.236
76.098
1.00
31.53
6

ATOM
5593
CG2
ILE
A
1012
84.455
36.631
75.715
1.00
32.31
6

ATOM
5594
CG1
ILE
A
1012
83.658
34.354
76.296
1.00
33.51
6

ATOM
5595
CD1
ILE
A
1012
82.677
34.876
77.333
1.00
37.18
6

ATOM
5596
C
ILE
A
1012
87.041
35.490
74.786
1.00
28.24
6

ATOM
5597
O
ILE
A
1012
87.160
36.182
73.765
1.00
27.84
8

ATOM
5598
N
CYS
A
1013
87.971
35.444
75.742
1.00
27.17
7

ATOM
5599
CA
CYS
A
1013
89.211
36.228
75.655
1.00
27.49
6

ATOM
5600
CB
CYS
A
1013
90.145
35.916
76.828
1.00
26.31
6

ATOM
5601
SG
CYS
A
1013
89.807
36.774
78.387
1.00
28.87
16

ATOM
5602
C
CYS
A
1013
89.984
35.971
74.355
1.00
29.10
6

ATOM
5603
O
CYS
A
1013
90.356
36.911
73.641
1.00
25.44
8

ATOM
5604
N
VAL
A
1014
90.248
34.696
74.066
1.00
29.24
7

ATOM
5605
CA
VAL
A
1014
90.984
34.339
72.856
1.00
29.48
6

ATOM
5606
CB
VAL
A
1014
91.189
32.808
72.733
1.00
28.90
6

ATOM
5607
CG1
VAL
A
1014
91.691
32.457
71.330
1.00
27.17
6

ATOM
5608
CG2
VAL
A
1014
92.194
32.344
73.765
1.00
29.50
6

ATOM
5609
C
VAL
A
1014
90.288
34.831
71.598
1.00
28.98
6

ATOM
5610
O
VAL
A
1014
90.928
35.386
70.714
1.00
29.45
8

ATOM
5611
N
LYS
A
1015
88.982
34.619
71.515
1.00
31.22
7

ATOM
5612
CA
LYS
A
1015
88.228
35.041
70.344
1.00
33.01
6

ATOM
5613
CB
LYS
A
1015
86.798
34.506
70.408
1.00
36.59
6

ATOM
5614
CG
LYS
A
1015
85.984
34.824
69.166
1.00
42.84
6

ATOM
5615
CD
LYS
A
1015
84.588
34.241
69.240
1.00
47.48
6

ATOM
5616
CE
LYS
A
1015
83.789
34.573
67.983
1.00
49.76
6

ATOM
5617
NZ
LYS
A
1015
82.353
34.167
68.113
1.00
52.04
7

ATOM
5618
C
LYS
A
1015
88.195
36.559
70.221
1.00
32.44
6

ATOM
5619
O
LYS
A
1015
88.235
37.100
69.118
1.00
31.70
8

ATOM
5620
N
ALA
A
1016
88.111
37.243
71.357
1.00
30.35
7

ATOM
5621
CA
ALA
A
1016
88.071
38.702
71.355
1.00
29.73
6

ATOM
5622
CB
ALA
A
1016
87.703
39.223
72.740
1.00
28.52
6

ATOM
5623
C
ALA
A
1016
89.427
39.240
70.948
1.00
27.57
6

ATOM
5624
O
ALA
A
1016
89.532
40.212
70.199
1.00
27.03
8

ATOM
5625
N
TYR
A
1017
90.469
38.590
71.444
1.00
25.18
7

ATOM
5626
CA
TYR
A
1017
91.834
39.007
71.162
1.00
27.03
6

ATOM
5627
CB
TYR
A
1017
92.796
38.264
72.087
1.00
25.14
6

ATOM
5628
CG
TYR
A
1017
94.264
38.558
71.869
1.00
25.98
6

ATOM
5629
CD1
TYR
A
1017
94.773
39.852
72.018
1.00
26.31
6

ATOM
5630
CE1
TYR
A
1017
96.125
40.114
71.855
1.00
26.50
6

ATOM
5631
CD2
TYR
A
1017
95.151
37.536
71.546
1.00
23.86
6

ATOM
5632
CE2
TYR
A
1017
96.502
37.785
71.374
1.00
27.13
6

ATOM
5633
CZ
TYR
A
1017
96.982
39.074
71.530
1.00
25.88
6

ATOM
5634
OH
TYR
A
1017
98.317
39.319
71.362
1.00
29.91
8

ATOM
5635
C
TYR
A
1017
92.233
38.798
69.702
1.00
27.27
6

ATOM
5636
O
TYR
A
1017
92.813
39.686
69.086
1.00
26.20
8

ATOM
5637
N
LEU
A
1018
91.938
37.630
69.152
1.00
28.76
7

ATOM
5638
CA
LEU
A
1018
92.306
37.434
67.746
1.00
31.26
6

ATOM
5639
CB
LEU
A
1018
92.184
35.956
67.358
1.00
35.13
6

ATOM
5640
CG
LEU
A
1018
93.058
34.970
68.136
1.00
38.53
6

ATOM
5641
CD1
LEU
A
1018
92.827
33.547
67.650
1.00
40.26
6

ATOM
5642
CD2
LEU
A
1018
94.527
35.344
68.016
1.00
39.15
6

ATOM
5643
C
LEU
A
1018
91.445
38.287
66.811
1.00
30.45
6

ATOM
5644
O
LEU
A
1018
91.879
38.678
65.740
1.00
30.48
8

ATOM
5645
N
ALA
A
1019
90.229
38.596
67.268
1.00
28.02
7

ATOM
5646
CA
ALA
A
1019
89.358
39.458
66.488
1.00
27.22
6

ATOM
5647
CB
ALA
A
1019
87.975
39.525
67.128
1.00
29.42
6

ATOM
5648
C
ALA
A
1019
89.978
40.870
66.403
1.00
28.33
6

ATOM
5649
O
ALA
A
1019
89.825
41.556
65.389
1.00
29.72
8

ATOM
5650
N
LEU
A
1020
90.667
41.312
67.459
1.00
27.82
7

ATOM
5651
CA
LEU
A
1020
91.297
42.638
67.434
1.00
27.27
6

ATOM
5652
CB
LEU
A
1020
91.730
43.082
68.851
1.00
23.37
6

ATOM
5653
CG
LEU
A
1020
90.625
43.398
69.873
1.00
24.73
6

ATOM
5654
CD1
LEU
A
1020
91.231
44.066
71.095
1.00
27.48
6

ATOM
5655
CD2
LEU
A
1020
89.581
44.316
69.263
1.00
25.81
6

ATOM
5656
C
LEU
A
1020
92.519
42.626
66.496
1.00
27.87
6

ATOM
5657
O
LEU
A
1020
92.768
43.592
65.756
1.00
26.53
8

ATOM
5658
N
ARG
A
1021
93.269
41.528
66.530
1.00
27.15
7

ATOM
5659
CA
ARG
A
1021
94.454
41.379
65.692
1.00
30.63
6

ATOM
5660
CB
ARG
A
1021
95.162
40.053
65.991
1.00
28.33
6

ATOM
5661
CG
ARG
A
1021
95.616
39.929
67.432
1.00
29.38
6

ATOM
5662
CD
ARG
A
1021
96.338
38.618
67.723
1.00
29.69
6

ATOM
5663
NE
ARG
A
1021
97.636
38.515
67.054
1.00
32.93
7

ATOM
5664
CZ
ARG
A
1021
97.861
37.800
65.952
1.00
32.82
6

ATOM
5665
NH1
ARG
A
1021
96.876
37.117
65.388
1.00
31.06
7

ATOM
5666
NH2
ARG
A
1021
99.074
37.766
65.411
1.00
31.93
7

ATOM
5667
C
ARG
A
1021
94.121
41.472
64.202
1.00
30.35
6

ATOM
5668
O
ARG
A
1021
94.985
41.810
63.400
1.00
33.33
8

ATOM
5669
N
HIS
A
1022
92.875
41.177
63.843
1.00
30.72
7

ATOM
5670
CA
HIS
A
1022
92.424
41.248
62.453
1.00
31.74
6

ATOM
5671
CB
HIS
A
1022
91.051
40.577
62.306
1.00
34.08
6

ATOM
5672
CG
HIS
A
1022
91.060
39.099
62.574
1.00
36.26
6

ATOM
5673
CD2
HIS
A
1022
92.068
38.195
62.573
1.00
36.98
6

ATOM
5674
ND1
HIS
A
1022
89.915
38.393
62.879
1.00
37.46
7

ATOM
5675
CE1
HIS
A
1022
90.217
37.120
63.055
1.00
37.31
6

ATOM
5676
NE2
HIS
A
1022
91.518
36.972
62.876
1.00
36.81
7

ATOM
5677
C
HIS
A
1022
92.313
42.715
62.041
1.00
32.13
6

ATOM
5678
O
HIS
A
1022
92.137
43.041
60.862
1.00
33.00
8

ATOM
5679
N
HIS
A
1023
92.412
43.593
63.031
1.00
29.82
7

ATOM
5680
CA
HIS
A
1023
92.322
45.022
62.839
1.00
29.80
6

ATOM
5681
CB
HIS
A
1023
91.078
45.591
63.490
1.00
29.42
6

ATOM
5682
CG
HIS
A
1023
89.795
45.090
62.788
1.00
28.10
6

ATOM
5683
CD2
HIS
A
1023
89.102
43.931
62.904
1.00
25.68
6

ATOM
5684
ND1
HIS
A
1023
89.150
45.829
61.820
1.00
26.18
7

ATOM
5685
CE1
HIS
A
1023
88.112
45.147
61.368
1.00
25.30
6

ATOM
5686
NE2
HIS
A
1023
88.061
43.992
62.008
1.00
27.61
7

ATOM
5687
C
HIS
A
1023
93.549
45.682
63.397
1.00
28.34
6

ATOM
5688
O
HIS
A
1023
93.490
46.804
63.904
1.00
28.44
8

ATOM
5689
N
THR
A
1024
94.662
44.964
63.286
1.00
26.33
7

ATOM
5690
CA
THR
A
1024
95.941
45.424
63.833
1.00
27.35
6

ATOM
5691
CB
THR
A
1024
97.057
44.411
63.489
1.00
29.67
6

ATOM
5692
OG1
THR
A
1024
96.887
43.236
64.291
1.00
28.42
8

ATOM
5693
CG2
THR
A
1024
98.437
45.011
63.747
1.00
30.75
6

ATOM
5694
C
THR
A
1024
96.387
46.814
63.383
1.00
28.06
6

ATOM
5695
O
THR
A
1024
96.827
47.613
64.202
1.00
26.98
8

ATOM
5696
N
ASN
A
1025
96.275
47.128
62.101
1.00
26.47
7

ATOM
5697
CA
ASN
A
1025
96.706
48.423
61.621
1.00
26.63
6

ATOM
5698
CB
ASN
A
1025
96.668
48.472
60.093
1.00
27.64
6

ATOM
5699
CG
ASN
A
1025
97.356
49.703
59.532
1.00
31.86
6

ATOM
5700
OD1
ASN
A
1025
96.995
50.193
58.463
1.00
31.24
8

ATOM
5701
ND2
ASN
A
1025
98.349
50.204
60.256
1.00
32.19
7

ATOM
5702
C
ASN
A
1025
95.875
49.557
62.212
1.00
24.99
6

ATOM
5703
O
ASN
A
1025
96.404
50.554
62.699
1.00
27.11
8

ATOM
5704
N
LEU
A
1026
94.568
49.389
62.188
1.00
25.99
7

ATOM
5705
CA
LEU
A
1026
93.648
50.418
62.669
1.00
25.06
6

ATOM
5706
CB
LEU
A
1026
92.210
49.849
62.698
1.00
24.98
6

ATOM
5707
CG
LEU
A
1026
91.061
50.867
62.627
1.00
28.89
6

ATOM
5708
CD1
LEU
A
1026
89.887
50.403
63.462
1.00
26.26
6

ATOM
5709
CD2
LEU
A
1026
91.529
52.247
63.086
1.00
26.84
6

ATOM
5710
C
LEU
A
1026
94.009
51.002
64.017
1.00
25.98
6

ATOM
5711
O
LEU
A
1026
94.302
52.200
64.127
1.00
26.06
8

ATOM
5712
N
LEU
A
1027
93.977
50.214
65.041
1.00
53.16
7

ATOM
5713
CA
LEU
A
1027
94.312
50.783
66.305
1.00
53.16
6

ATOM
5714
CB
LEU
A
1027
94.350
49.710
67.365
1.00
53.16
6

ATOM
5715
CG
LEU
A
1027
93.108
48.839
67.356
1.00
53.16
6

ATOM
5716
CD1
LEU
A
1027
93.243
47.722
68.386
1.00
53.16
6

ATOM
5717
CD2
LEU
A
1027
91.855
49.678
67.613
1.00
53.16
6

ATOM
5718
C
LEU
A
1027
95.622
51.557
66.244
1.00
53.16
6

ATOM
5719
O
LEU
A
1027
95.751
52.604
66.896
1.00
53.16
8

ATOM
5720
N
ILE
A
1028
96.599
51.060
65.476
1.00
53.16
7

ATOM
5721
CA
ILE
A
1028
97.888
51.710
65.374
1.00
53.16
6

ATOM
5722
CB
ILE
A
1028
98.922
50.775
64.801
1.00
53.16
6

ATOM
5723
CG2
ILE
A
1028
100.266
51.470
64.633
1.00
53.16
6

ATOM
5724
CG1
ILE
A
1028
99.063
49.577
65.733
1.00
53.16
6

ATOM
5725
CD1
ILE
A
1028
99.902
48.453
65.160
1.00
53.16
6

ATOM
5726
C
ILE
A
1028
97.786
52.960
64.543
1.00
53.16
6

ATOM
5727
O
ILE
A
1028
98.525
53.923
64.745
1.00
53.16
8

ATOM
5728
N
ILE
A
1029
96.861
52.952
63.602
1.00
53.16
7

ATOM
5729
CA
ILE
A
1029
96.664
54.111
62.756
1.00
53.16
6

ATOM
5730
CB
ILE
A
1029
95.787
53.750
61.532
1.00
53.16
6

ATOM
5731
CG2
ILE
A
1029
94.401
53.326
61.987
1.00
53.16
6

ATOM
5732
CG1
ILE
A
1029
95.723
54.920
60.552
1.00
53.16
6

ATOM
5733
CD1
ILE
A
1029
94.969
56.124
61.078
1.00
53.16
6

ATOM
5734
C
ILE
A
1029
95.991
55.179
63.624
1.00
53.16
6

ATOM
5735
O
ILE
A
1029
96.372
56.347
63.588
1.00
53.16
8

ATOM
5736
N
LEU
A
1030
95.008
54.758
64.418
1.00
53.16
7

ATOM
5737
CA
LEU
A
1030
94.302
55.664
65.332
1.00
53.16
6

ATOM
5738
CB
LEU
A
1030
93.198
54.928
66.117
1.00
53.16
6

ATOM
5739
CG
LEU
A
1030
92.003
54.323
65.368
1.00
53.16
6

ATOM
5740
CD1
LEU
A
1030
91.075
53.597
66.339
1.00
53.16
6

ATOM
5741
CD2
LEU
A
1030
91.249
55.407
64.622
1.00
53.16
6

ATOM
5742
C
LEU
A
1030
95.246
56.309
66.365
1.00
53.16
6

ATOM
5743
O
LEU
A
1030
95.169
57.511
66.659
1.00
53.16
8

ATOM
5744
N
PHE
A
1031
96.111
55.477
66.903
1.00
53.16
7

ATOM
5745
CA
PHE
A
1031
97.061
55.815
67.930
1.00
53.16
6

ATOM
5746
CB
PHE
A
1031
97.969
54.647
68.229
1.00
53.16
6

ATOM
5747
CG
PHE
A
1031
97.767
54.390
69.629
1.00
53.16
6

ATOM
5748
CD1
PHE
A
1031
96.628
53.685
69.994
1.00
53.16
6

ATOM
5749
CD2
PHE
A
1031
98.625
54.888
70.595
1.00
53.16
6

ATOM
5750
CE1
PHE
A
1031
96.334
53.493
71.328
1.00
53.16
6

ATOM
5751
CE2
PHE
A
1031
98.315
54.705
71.932
1.00
53.16
6

ATOM
5752
CZ
PHE
A
1031
97.166
54.002
72.287
1.00
53.16
6

ATOM
5753
C
PHE
A
1031
98.016
56.894
67.553
1.00
53.16
6

ATOM
5754
O
PHE
A
1031
97.958
58.062
67.934
1.00
53.16
8

ATOM
5755
N
SER
A
1032
98.897
56.400
66.763
1.00
53.16
7

ATOM
5756
CA
SER
A
1032
99.906
57.174
66.204
1.00
53.16
6

ATOM
5757
CB
SER
A
1032
100.192
56.681
64.774
1.00
53.16
6

ATOM
5758
OG
SER
A
1032
99.549
55.440
64.525
1.00
53.16
8

ATOM
5759
C
SER
A
1032
99.470
58.620
66.224
1.00
53.16
6

ATOM
5760
O
SER
A
1032
99.985
59.427
66.999
1.00
53.16
8

ATOM
5761
N
MET
A
1033
98.511
58.949
65.367
1.00
53.16
7

ATOM
5762
CA
MET
A
1033
98.032
60.309
65.333
1.00
53.16
6

ATOM
5763
CB
MET
A
1033
96.663
60.404
64.653
1.00
53.16
6

ATOM
5764
CG
MET
A
1033
96.604
59.757
63.294
1.00
53.16
6

ATOM
5765
SD
MET
A
1033
94.970
59.901
62.550
1.00
53.16
16

ATOM
5766
CE
MET
A
1033
95.043
61.552
61.856
1.00
53.16
6

ATOM
5767
C
MET
A
1033
97.936
60.876
66.764
1.00
53.16
6

ATOM
5768
O
MET
A
1033
98.949
61.264
67.355
1.00
53.16
8

ATOM
5769
N
MET
A
1034
96.745
60.929
67.304
1.00
53.16
7

ATOM
5770
CA
MET
A
1034
96.522
61.530
68.624
1.00
53.16
6

ATOM
5771
CB
MET
A
1034
95.424
60.788
69.370
1.00
208.01
6

ATOM
5772
CG
MET
A
1034
94.584
61.736
70.202
1.00
208.01
6

ATOM
5773
SD
MET
A
1034
93.301
60.886
71.138
1.00
208.01
16

ATOM
5774
CE
MET
A
1034
94.289
60.015
72.351
1.00
208.01
6

ATOM
5775
C
MET
A
1034
97.751
61.715
69.499
1.00
53.16
6

ATOM
5776
O
MET
A
1034
97.931
62.803
70.046
1.00
53.16
8

ATOM
5777
N
LEU
A
1035
98.567
60.730
69.658
1.00
70.80
7

ATOM
5778
CA
LEU
A
1035
99.700
61.018
70.488
1.00
70.80
6

ATOM
5779
CB
LEU
A
1035
100.512
59.778
70.781
1.00
125.69
6

ATOM
5780
CG
LEU
A
1035
100.364
59.269
72.196
1.00
125.69
6

ATOM
5781
CD1
LEU
A
1035
98.939
59.402
72.673
1.00
125.69
6

ATOM
5782
CD2
LEU
A
1035
100.835
57.822
72.299
1.00
125.69
6

ATOM
5783
C
LEU
A
1035
100.562
62.067
69.807
1.00
70.80
6

ATOM
5784
O
LEU
A
1035
100.678
63.178
70.334
1.00
70.80
8

ATOM
5785
N
MET
A
1036
101.161
61.762
68.688
1.00
114.89
7

ATOM
5786
CA
MET
A
1036
101.926
62.857
68.185
1.00
114.89
6

ATOM
5787
CB
MET
A
1036
101.701
63.110
66.691
1.00
164.85
6

ATOM
5788
CG
MET
A
1036
102.415
62.138
65.765
1.00
164.85
6

ATOM
5789
SD
MET
A
1036
103.999
61.600
66.420
1.00
170.26
16

ATOM
5790
CE
MET
A
1036
104.607
60.618
65.055
1.00
168.19
6

ATOM
5791
C
MET
A
1036
101.426
64.057
69.043
1.00
114.89
6

ATOM
5792
O
MET
A
1036
102.132
65.040
69.246
1.00
114.89
8

ATOM
5793
N
THR
A
1037
100.172
63.871
69.564
1.00
171.76
7

ATOM
5794
CA
THR
A
1037
99.274
64.858
70.290
1.00
171.76
6

ATOM
5795
CB
THR
A
1037
97.828
64.739
69.788
1.00
189.82
6

ATOM
5796
OG1
THR
A
1037
97.377
66.001
69.267
1.00
189.82
8

ATOM
5797
CG2
THR
A
1037
96.911
64.308
70.923
1.00
189.82
6

ATOM
5798
C
THR
A
1037
98.899
64.663
71.762
1.00
171.76
6

ATOM
5799
O
THR
A
1037
97.815
65.122
72.129
1.00
171.76
8

ATOM
5800
N
GLY
A
1038
99.635
64.047
72.666
1.00
192.87
7

ATOM
5801
CA
GLY
A
1038
98.987
63.757
73.978
1.00
198.17
6

ATOM
5802
C
GLY
A
1038
99.388
64.530
75.239
1.00
201.70
6

ATOM
5803
O
GLY
A
1038
98.555
64.928
76.039
1.00
201.70
8

ATOM
5804
N
GLU
A
1046
109.105
54.836
72.571
1.00
208.41
7

ATOM
5805
CA
GLU
A
1046
107.968
55.471
71.924
1.00
208.41
6

ATOM
5806
CB
GLU
A
1046
108.030
55.233
70.422
1.00
207.86
6

ATOM
5807
CG
GLU
A
1046
108.010
56.501
69.583
1.00
208.41
6

ATOM
5808
CD
GLU
A
1046
109.104
56.531
68.512
1.00
208.41
6

ATOM
5809
OE1
GLU
A
1046
109.354
55.461
67.888
1.00
208.41
8

ATOM
5810
OE2
GLU
A
1046
109.712
57.591
68.297
1.00
208.41
8

ATOM
5811
C
GLU
A
1046
106.642
54.975
72.510
1.00
208.41
6

ATOM
5812
O
GLU
A
1046
106.240
55.336
73.613
1.00
207.33
8

ATOM
5813
N
ASP
A
1047
106.100
53.943
71.727
1.00
133.52
7

ATOM
5814
CA
ASP
A
1047
104.928
53.072
72.011
1.00
132.40
6

ATOM
5815
CB
ASP
A
1047
104.612
53.113
73.498
1.00
172.55
6

ATOM
5816
CG
ASP
A
1047
105.448
52.034
74.159
1.00
174.95
6

ATOM
5817
OD1
ASP
A
1047
104.942
50.896
74.272
1.00
176.37
8

ATOM
5818
OD2
ASP
A
1047
106.600
52.336
74.552
1.00
176.61
8

ATOM
5819
C
ASP
A
1047
103.704
53.279
71.113
1.00
131.14
6

ATOM
5820
O
ASP
A
1047
102.864
54.147
71.305
1.00
131.06
8

ATOM
5821
N
ILE
A
1048
103.676
52.422
70.135
1.00
53.16
7

ATOM
5822
CA
ILE
A
1048
102.761
52.251
69.023
1.00
53.16
6

ATOM
5823
CB
ILE
A
1048
103.038
53.306
67.940
1.00
147.54
6

ATOM
5824
CG2
ILE
A
1048
104.091
52.801
66.966
1.00
147.03
6

ATOM
5825
CG1
ILE
A
1048
101.766
53.689
67.184
1.00
148.57
6

ATOM
5826
CD1
ILE
A
1048
101.156
52.551
66.392
1.00
133.82
6

ATOM
5827
C
ILE
A
1048
103.248
50.896
68.631
1.00
53.16
6

ATOM
5828
O
ILE
A
1048
102.760
50.162
67.771
1.00
53.16
8

ATOM
5829
N
GLU
A
1049
104.304
50.718
69.437
1.00
59.93
7

ATOM
5830
CA
GLU
A
1049
105.135
49.568
69.556
1.00
59.43
6

ATOM
5831
CB
GLU
A
1049
106.630
49.919
69.670
1.00
167.62
6

ATOM
5832
CG
GLU
A
1049
107.447
49.023
68.738
1.00
172.10
6

ATOM
5833
CD
GLU
A
1049
108.832
49.558
68.373
1.00
175.65
6

ATOM
5834
OE1
GLU
A
1049
108.928
50.490
67.545
1.00
177.55
8

ATOM
5835
OE2
GLU
A
1049
109.813
49.052
68.936
1.00
178.24
8

ATOM
5836
C
GLU
A
1049
104.637
48.728
70.727
1.00
57.90
6

ATOM
5837
O
GLU
A
1049
104.608
47.510
70.586
1.00
59.47
8

ATOM
5838
N
TYR
A
1050
104.240
49.318
71.879
1.00
71.92
7

ATOM
5839
CA
TYR
A
1050
103.710
48.402
72.897
1.00
67.86
6

ATOM
5840
CB
TYR
A
1050
103.436
48.952
74.300
1.00
107.06
6

ATOM
5841
CG
TYR
A
1050
103.066
47.801
75.236
1.00
104.92
6

ATOM
5842
CD1
TYR
A
1050
104.073
47.085
75.886
1.00
104.95
6

ATOM
5843
CE1
TYR
A
1050
103.769
46.003
76.715
1.00
105.25
6

ATOM
5844
CD2
TYR
A
1050
101.744
47.406
75.442
1.00
102.95
6

ATOM
5845
CE2
TYR
A
1050
101.433
46.323
76.269
1.00
104.05
6

ATOM
5846
CZ
TYR
A
1050
102.452
45.625
76.900
1.00
104.33
6

ATOM
5847
OH
TYR
A
1050
102.163
44.544
77.704
1.00
104.43
8

ATOM
5848
C
TYR
A
1050
102.391
47.897
72.351
1.00
67.37
6

ATOM
5849
O
TYR
A
1050
101.981
46.791
72.675
1.00
64.41
8

ATOM
5850
N
ILE
A
1051
102.043
48.475
71.755
1.00
39.30
7

ATOM
5851
CA
ILE
A
1051
100.896
47.854
71.115
1.00
39.35
6

ATOM
5852
CB
ILE
A
1051
99.928
48.916
70.536
1.00
39.54
6

ATOM
5853
CG2
ILE
A
1051
100.474
49.485
69.224
1.00
39.48
6

ATOM
5854
CG1
ILE
A
1051
98.544
48.283
70.342
1.00
37.48
6

ATOM
5855
CD1
ILE
A
1051
97.460
49.248
69.910
1.00
41.66
6

ATOM
5856
C
ILE
A
1051
101.258
46.842
70.031
1.00
40.18
6

ATOM
5857
O
ILE
A
1051
100.490
45.920
69.761
1.00
39.01
8

ATOM
5858
N
ARG
A
1052
102.417
47.036
69.409
1.00
40.41
7

ATOM
5859
CA
ARG
A
1052
102.869
46.078
68.411
1.00
41.90
6

ATOM
5860
CB
ARG
A
1052
104.123
46.586
67.703
1.00
46.30
6

ATOM
5861
CG
ARG
A
1052
103.941
47.900
66.967
1.00
51.38
6

ATOM
5862
CD
ARG
A
1052
105.244
48.346
66.327
1.00
54.14
6

ATOM
5863
NE
ARG
A
1052
105.199
48.264
64.872
1.00
56.54
7

ATOM
5864
CZ
ARG
A
1052
106.243
48.487
64.083
1.00
58.76
6

ATOM
5865
NH1
ARG
A
1052
107.416
48.806
64.612
1.00
57.11
7

ATOM
5866
NH2
ARG
A
1052
106.113
48.389
62.767
1.00
58.91
7

ATOM
5867
C
ARG
A
1052
103.154
44.718
69.030
1.00
40.79
6

ATOM
5868
O
ARG
A
1052
102.710
43.698
68.557
1.00
39.07
8

ATOM
5869
N
ASP
A
1053
103.853
44.765
70.176
1.00
40.45
7

ATOM
5870
CA
ASP
A
1053
104.144
43.533
70.902
1.00
40.24
6

ATOM
5871
CB
ASP
A
1053
105.175
43.769
72.017
1.00
43.92
6

ATOM
5872
CG
ASP
A
1053
106.528
44.232
71.493
1.00
47.20
6

ATOM
5873
OD1
ASP
A
1053
106.894
43.874
70.352
1.00
48.44
8

ATOM
5874
OD2
ASP
A
1053
107.240
44.943
72.240
1.00
49.28
8

ATOM
5875
C
ASP
A
1053
102.860
42.980
71.526
1.00
39.20
6

ATOM
5876
O
ASP
A
1053
102.619
41.772
71.489
1.00
38.81
8

ATOM
5877
N
ALA
A
1054
102.036
43.865
72.093
1.00
35.67
7

ATOM
5878
CA
ALA
A
1054
100.787
43.448
72.727
1.00
34.45
6

ATOM
5879
CB
ALA
A
1054
100.058
44.654
73.323
1.00
35.08
6

ATOM
5880
C
ALA
A
1054
99.880
42.730
71.742
1.00
33.22
6

ATOM
5881
O
ALA
A
1054
99.153
41.822
72.113
1.00
32.20
8

ATOM
5882
N
LEU
A
1055
99.922
43.150
70.486
1.00
33.58
7

ATOM
5883
CA
LEU
A
1055
99.104
42.524
69.450
1.00
34.78
6

ATOM
5884
CB
LEU
A
1055
98.697
43.559
68.410
1.00
31.17
6

ATOM
5885
CG
LEU
A
1055
97.637
44.535
68.926
1.00
29.73
6

ATOM
5886
CD1
LEU
A
1055
97.535
45.707
67.982
1.00
26.72
6

ATOM
5887
CD2
LEU
A
1055
96.291
43.813
69.081
1.00
26.17
6

ATOM
5888
C
LEU
A
1055
99.874
41.390
68.789
1.00
35.64
6

ATOM
5889
O
LEU
A
1055
99.476
40.882
67.740
1.00
35.02
8

ATOM
5890
N
THR
A
1056
100.968
40.990
69.430
1.00
38.51
7

ATOM
5891
CA
THR
A
1056
101.822
39.918
68.931
1.00
42.12
6

ATOM
5892
CB
THR
A
1056
101.317
38.533
69.423
1.00
42.48
6

ATOM
5893
OG1
THR
A
1056
102.105
37.499
68.823
1.00
49.40
8

ATOM
5894
CG2
THR
A
1056
99.861
38.320
69.061
1.00
43.09
6

ATOM
5895
C
THR
A
1056
101.898
39.951
67.400
1.00
42.96
6

ATOM
5896
O
THR
A
1056
101.614
38.959
66.721
1.00
42.73
8

ATOM
5897
N
VAL
A
1057
102.279
41.112
66.871
1.00
42.66
7

ATOM
5898
CA
VAL
A
1057
102.398
41.316
65.433
1.00
44.19
6

ATOM
5899
CB
VAL
A
1057
102.828
42.764
65.114
1.00
44.89
6

ATOM
5900
CG1
VAL
A
1057
103.118
42.910
63.631
1.00
44.47
6

ATOM
5901
CG2
VAL
A
1057
101.730
43.734
65.528
1.00
44.12
6

ATOM
5902
C
VAL
A
1057
103.395
40.366
64.784
1.00
45.84
6

ATOM
5903
O
VAL
A
1057
104.517
40.200
65.265
1.00
45.98
8

ATOM
5904
N
GLY
A
1058
102.975
39.742
63.690
1.00
46.50
7

ATOM
5905
CA
GLY
A
1058
103.849
38.829
62.984
1.00
49.30
6

ATOM
5906
C
GLY
A
1058
103.562
37.358
63.202
1.00
50.55
6

ATOM
5907
O
GLY
A
1058
103.760
36.550
62.299
1.00
51.66
8

ATOM
5908
N
LYS
A
1059
103.067
36.989
64.385
1.00
50.32
7

ATOM
5909
CA
LYS
A
1059
102.819
35.596
64.713
1.00
49.64
6

ATOM
5910
CB
LYS
A
1059
102.904
35.388
66.224
1.00
51.29
6

ATOM
5911
CG
LYS
A
1059
104.265
35.724
66.814
1.00
53.09
6

ATOM
5912
CD
LYS
A
1059
104.362
35.288
68.265
1.00
56.35
6

ATOM
5913
CE
LYS
A
1059
105.721
35.632
68.854
1.00
58.08
6

ATOM
5914
NZ
LYS
A
1059
105.835
35.205
70.275
1.00
59.17
7

ATOM
5915
C
LYS
A
1059
101.470
35.146
64.170
1.00
48.94
6

ATOM
5916
O
LYS
A
1059
100.549
35.916
63.941
1.00
48.33
8

ATOM
5917
N
ASN
A
1060
101.344
33.841
63.954
1.00
48.46
7

ATOM
5918
CA
ASN
A
1060
100.109
33.218
63.479
1.00
47.99
6

ATOM
5919
CB
ASN
A
1060
100.392
31.812
62.940
1.00
49.47
6

ATOM
5920
CG
ASN
A
1060
100.563
30.798
64.045
1.00
49.99
6

ATOM
5921
OD1
ASN
A
1060
101.569
30.822
64.752
1.00
51.12
8

ATOM
5922
ND2
ASN
A
1060
99.593
29.908
64.210
1.00
52.46
7

ATOM
5923
C
ASN
A
1060
99.079
33.148
64.594
1.00
47.02
6

ATOM
5924
O
ASN
A
1060
99.366
33.419
65.762
1.00
46.58
8

ATOM
5925
N
GLU
A
1061
97.880
32.769
64.237
1.00
46.13
7

ATOM
5926
CA
GLU
A
1061
96.785
32.765
65.194
1.00
47.21
6

ATOM
5927
CB
GLU
A
1061
95.455
32.554
64.475
1.00
47.08
6

ATOM
5928
CG
GLU
A
1061
94.919
33.846
63.869
1.00
49.64
6

ATOM
5929
CD
GLU
A
1061
93.430
33.833
63.598
1.00
51.35
6

ATOM
5930
OE1
GLU
A
1061
92.884
34.911
63.315
1.00
53.04
8

ATOM
5931
OE2
GLU
A
1061
92.805
32.753
63.666
1.00
53.48
8

ATOM
5932
C
GLU
A
1061
96.995
31.827
66.360
1.00
46.86
6

ATOM
5933
O
GLU
A
1061
96.974
32.287
67.489
1.00
46.22
8

ATOM
5934
N
GLU
A
1062
97.206
30.565
66.174
1.00
46.82
7

ATOM
5935
CA
GLU
A
1062
97.395
29.728
67.339
1.00
47.47
6

ATOM
5936
CB
GLU
A
1062
97.736
28.296
66.933
1.00
49.16
6

ATOM
5937
CG
GLU
A
1062
96.553
27.320
66.937
1.00
51.24
6

ATOM
5938
CD
GLU
A
1062
95.660
27.339
68.165
1.00
52.23
6

ATOM
5939
OE1
GLU
A
1062
96.183
27.320
69.299
1.00
53.22
8

ATOM
5940
OE2
GLU
A
1062
94.425
27.365
67.990
1.00
54.15
8

ATOM
5941
C
GLU
A
1062
98.477
30.278
68.315
1.00
46.24
6

ATOM
5942
O
GLU
A
1062
98.206
30.324
69.520
1.00
44.89
8

ATOM
5943
N
ASP
A
1063
99.673
30.681
67.856
1.00
46.08
7

ATOM
5944
CA
ASP
A
1063
100.685
31.255
68.771
1.00
47.05
6

ATOM
5945
CB
ASP
A
1063
101.978
31.649
68.044
1.00
49.11
6

ATOM
5946
CG
ASP
A
1063
102.831
30.439
67.679
1.00
52.57
6

ATOM
5947
OD1
ASP
A
1063
102.989
29.542
68.530
1.00
53.45
8

ATOM
5948
OD2
ASP
A
1063
103.328
30.388
66.531
1.00
52.95
8

ATOM
5949
C
ASP
A
1063
100.105
32.471
69.474
1.00
45.56
6

ATOM
5950
O
ASP
A
1063
100.449
32.748
70.631
1.00
45.06
8

ATOM
5951
N
ALA
A
1064
99.235
33.193
68.775
1.00
44.08
7

ATOM
5952
CA
ALA
A
1064
98.583
34.361
69.363
1.00
41.41
6

ATOM
5953
CB
ALA
A
1064
97.722
35.064
68.321
1.00
39.65
6

ATOM
5954
C
ALA
A
1064
97.719
33.860
70.520
1.00
39.90
6

ATOM
5955
O
ALA
A
1064
97.852
34.310
71.663
1.00
37.36
8

ATOM
5956
N
LYS
A
1065
96.836
32.915
70.208
1.00
39.14
7

ATOM
5957
CA
LYS
A
1065
95.959
32.320
71.205
1.00
38.66
6

ATOM
5958
CB
LYS
A
1065
95.228
31.121
70.598
1.00
38.31
6

ATOM
5959
CG
LYS
A
1065
94.507
30.240
71.600
1.00
36.74
6

ATOM
5960
CD
LYS
A
1065
93.660
29.189
70.897
1.00
37.98
6

ATOM
5961
CE
LYS
A
1065
93.042
28.224
71.903
1.00
38.37
6

ATOM
5962
NZ
LYS
A
1065
92.053
27.296
71.279
1.00
38.40
7

ATOM
5963
C
LYS
A
1065
96.806
31.876
72.391
1.00
39.41
6

ATOM
5964
O
LYS
A
1065
96.509
32.197
73.544
1.00
38.65
8

ATOM
5965
N
LYS
A
1066
97.868
31.138
72.092
1.00
39.20
7

ATOM
5966
CA
LYS
A
1066
98.782
30.645
73.112
1.00
39.98
6

ATOM
5967
CB
LYS
A
1066
99.958
29.930
72.440
1.00
41.32
6

ATOM
5968
CG
LYS
A
1066
101.177
29.741
73.327
1.00
45.57
6

ATOM
5969
CD
LYS
A
1066
100.859
28.893
74.543
1.00
48.70
6

ATOM
5970
CE
LYS
A
1066
102.119
28.574
75.336
1.00
50.40
6

ATOM
5971
NZ
LYS
A
1066
101.790
27.827
76.579
1.00
51.30
7

ATOM
5972
C
LYS
A
1066
99.309
31.790
73.973
1.00
39.09
6

ATOM
5973
O
LYS
A
1066
99.337
31.701
75.199
1.00
39.69
8

ATOM
5974
N
TYR
A
1067
99.733
32.862
73.317
1.00
38.17
7

ATOM
5975
CA
TYR
A
1067
100.274
34.020
74.006
1.00
37.69
6

ATOM
5976
CB
TYR
A
1067
100.676
35.089
72.985
1.00
38.53
6

ATOM
5977
CG
TYR
A
1067
101.196
36.375
73.591
1.00
38.05
6

ATOM
5978
CD1
TYR
A
1067
100.370
37.498
73.712
1.00
38.56
6

ATOM
5979
CE1
TYR
A
1067
100.848
38.689
74.266
1.00
37.98
6

ATOM
5980
CD2
TYR
A
1067
102.511
36.471
74.043
1.00
36.98
6

ATOM
5981
CE2
TYR
A
1067
102.996
37.653
74.599
1.00
38.27
6

ATOM
5982
CZ
TYR
A
1067
102.161
38.757
74.706
1.00
38.75
6

ATOM
5983
OH
TYR
A
1067
102.650
39.927
75.246
1.00
39.46
8

ATOM
5984
C
TYR
A
1067
99.306
34.603
75.023
1.00
35.64
6

ATOM
5985
O
TYR
A
1067
99.685
34.847
76.166
1.00
35.55
8

ATOM
5986
N
PHE
A
1068
98.058
34.818
74.623
1.00
36.57
7

ATOM
5987
CA
PHE
A
1068
97.087
35.396
75.550
1.00
36.00
6

ATOM
5988
CB
PHE
A
1068
95.788
35.780
74.839
1.00
36.07
6

ATOM
5989
CG
PHE
A
1068
94.953
36.746
75.629
1.00
33.51
6

ATOM
5990
CD1
PHE
A
1068
95.133
38.120
75.481
1.00
33.84
6

ATOM
5991
CD2
PHE
A
1068
94.075
36.287
76.607
1.00
31.73
6

ATOM
5992
CE1
PHE
A
1068
94.456
39.025
76.307
1.00
34.00
6

ATOM
5993
CE2
PHE
A
1068
93.393
37.179
77.439
1.00
32.54
6

ATOM
5994
CZ
PHE
A
1068
93.587
38.553
77.290
1.00
34.18
6

ATOM
5995
C
PHE
A
1068
96.756
34.458
76.704
1.00
36.27
6

ATOM
5996
O
PHE
A
1068
96.627
34.892
77.849
1.00
36.86
8

ATOM
5997
N
LEU
A
1069
96.601
33.173
76.408
1.00
36.86
7

ATOM
5998
CA
LEU
A
1069
96.291
32.205
77.455
1.00
37.68
6

ATOM
5999
CB
LEU
A
1069
96.167
30.802
76.859
1.00
36.27
6

ATOM
6000
CG
LEU
A
1069
94.889
30.661
76.032
1.00
37.02
6

ATOM
6001
CD1
LEU
A
1069
94.866
29.341
75.282
1.00
35.37
6

ATOM
6002
CD2
LEU
A
1069
93.694
30.774
76.974
1.00
36.72
6

ATOM
6003
C
LEU
A
1069
97.368
32.247
78.534
1.00
37.68
6

ATOM
6004
O
LEU
A
1069
97.071
32.129
79.719
1.00
39.40
8

ATOM
6005
N
ASP
A
1070
98.617
32.442
78.123
1.00
38.74
7

ATOM
6006
CA
ASP
A
1070
99.718
32.518
79.070
1.00
39.24
6

ATOM
6007
CB
ASP
A
1070
101.063
32.481
78.333
1.00
40.04
6

ATOM
6008
CG
ASP
A
1070
101.339
31.128
77.696
1.00
44.75
6

ATOM
6009
OD1
ASP
A
1070
102.462
30.918
77.193
1.00
46.70
8

ATOM
6010
OD2
ASP
A
1070
100.434
30.268
77.697
1.00
45.89
8

ATOM
6011
C
ASP
A
1070
99.611
33.796
79.908
1.00
39.89
6

ATOM
6012
O
ASP
A
1070
100.014
33.818
81.067
1.00
39.66
8

ATOM
6013
N
GLN
A
1071
99.074
34.865
79.325
1.00
39.00
7

ATOM
6014
CA
GLN
A
1071
98.926
36.105
80.079
1.00
37.93
6

ATOM
6015
CB
GLN
A
1071
98.421
37.241
79.179
1.00
37.55
6

ATOM
6016
CG
GLN
A
1071
99.372
37.645
78.058
1.00
37.23
6

ATOM
6017
CD
GLN
A
1071
100.789
37.895
78.549
1.00
41.71
6

ATOM
6018
OE1
GLN
A
1071
101.003
38.525
79.587
1.00
41.81
8

ATOM
6019
NE2
GLN
A
1071
101.769
37.404
77.798
1.00
44.19
7

ATOM
6020
C
GLN
A
1071
97.929
35.844
81.209
1.00
36.56
6

ATOM
6021
O
GLN
A
1071
98.092
36.338
82.326
1.00
37.36
8

ATOM
6022
N
ILE
A
1072
96.905
35.052
80.912
1.00
36.58
7

ATOM
6023
CA
ILE
A
1072
95.887
34.707
81.897
1.00
38.85
6

ATOM
6024
CB
ILE
A
1072
94.768
33.832
81.262
1.00
38.98
6

ATOM
6025
CG2
ILE
A
1072
93.917
33.185
82.350
1.00
36.69
6

ATOM
6026
CG1
ILE
A
1072
93.903
34.691
80.332
1.00
39.19
6

ATOM
6027
CD1
ILE
A
1072
92.802
33.924
79.619
1.00
38.94
6

ATOM
6028
C
ILE
A
1072
96.531
33.946
83.059
1.00
40.31
6

ATOM
6029
O
ILE
A
1072
96.137
34.102
84.220
1.00
40.30
8

ATOM
6030
N
GLU
A
1073
97.529
33.129
82.733
1.00
40.82
7

ATOM
6031
CA
GLU
A
1073
98.236
32.348
83.735
1.00
41.75
6

ATOM
6032
CB
GLU
A
1073
99.104
31.288
83.056
1.00
43.03
6

ATOM
6033
CG
GLU
A
1073
98.301
30.112
82.537
1.00
45.18
6

ATOM
6034
CD
GLU
A
1073
97.418
29.518
83.620
1.00
46.85
6

ATOM
6035
OE1
GLU
A
1073
97.955
29.169
84.696
1.00
49.00
8

ATOM
6036
OE2
GLU
A
1073
96.190
29.406
83.397
1.00
44.42
8

ATOM
6037
C
GLU
A
1073
99.093
33.222
84.641
1.00
41.37
6

ATOM
6038
O
GLU
A
1073
99.124
33.018
85.855
1.00
41.97
8

ATOM
6039
N
VAL
A
1074
99.790
34.191
84.059
1.00
40.60
7

ATOM
6040
CA
VAL
A
1074
100.621
35.079
84.856
1.00
40.80
6

ATOM
6041
CB
VAL
A
1074
101.249
36.191
83.995
1.00
42.91
6

ATOM
6042
CG1
VAL
A
1074
102.158
37.087
84.819
1.00
42.32
6

ATOM
6043
CG2
VAL
A
1074
102.029
35.576
82.840
1.00
43.22
6

ATOM
6044
C
VAL
A
1074
99.750
35.707
85.939
1.00
40.05
6

ATOM
6045
O
VAL
A
1074
100.199
35.921
87.062
1.00
40.30
8

ATOM
6046
N
CYS
A
1075
98.504
36.004
85.593
1.00
39.08
7

ATOM
6047
CA
CYS
A
1075
97.595
36.630
86.540
1.00
39.63
6

ATOM
6048
CB
CYS
A
1075
96.366
37.160
85.829
1.00
39.71
6

ATOM
6049
SG
CYS
A
1075
96.701
38.543
84.692
1.00
40.09
16

ATOM
6050
C
CYS
A
1075
97.143
35.661
87.649
1.00
41.23
6

ATOM
6051
O
CYS
A
1075
97.092
36.017
88.828
1.00
41.69
8

ATOM
6052
N
ARG
A
1076
96.829
34.406
87.234
1.00
41.04
7

ATOM
6053
CA
ARG
A
1076
96.351
33.280
88.048
1.00
42.95
6

ATOM
6054
CB
ARG
A
1076
95.974
32.103
87.165
1.00
43.58
6

ATOM
6055
CG
ARG
A
1076
94.727
32.300
86.329
1.00
46.19
6

ATOM
6056
CD
ARG
A
1076
93.715
31.236
86.645
1.00
47.98
6

ATOM
6057
NE
ARG
A
1076
94.170
29.903
86.243
1.00
51.87
7

ATOM
6058
CZ
ARG
A
1076
93.625
28.784
86.682
1.00
53.01
6

ATOM
6059
NH1
ARG
A
1076
92.637
28.826
87.555
1.00
53.91
7

ATOM
6060
NH2
ARG
A
1076
94.063
27.619
86.232
1.00
53.99
7

ATOM
6061
C
ARG
A
1076
97.396
32.778
88.975
1.00
41.88
6

ATOM
6062
O
ARG
A
1076
97.229
31.796
89.703
1.00
43.99
8

ATOM
6063
N
ASP
A
1077
98.498
33.489
88.945
1.00
42.14
7

ATOM
6064
CA
ASP
A
1077
99.616
33.108
89.728
1.00
42.73
6

ATOM
6065
CB
ASP
A
1077
100.622
32.431
88.830
1.00
45.06
6

ATOM
6066
CG
ASP
A
1077
99.860
31.489
87.909
1.00
49.08
6

ATOM
6067
OD1
ASP
A
1077
99.047
30.699
88.440
1.00
49.67
8

ATOM
6068
OD2
ASP
A
1077
100.067
31.530
86.677
1.00
51.30
8

ATOM
6069
C
ASP
A
1077
100.178
34.302
90.464
1.00
43.19
6

ATOM
6070
O
ASP
A
1077
101.027
34.149
91.354
1.00
44.32
8

ATOM
6071
N
LYS
A
1078
99.710
35.479
90.108
1.00
41.69
7

ATOM
6072
CA
LYS
A
1078
100.179
36.606
90.843
1.00
41.39
6

ATOM
6073
CB
LYS
A
1078
100.130
37.869
89.982
1.00
42.13
6

ATOM
6074
CG
LYS
A
1078
101.476
38.561
89.851
1.00
43.27
6

ATOM
6075
CD
LYS
A
1078
102.405
37.773
88.962
1.00
44.41
6

ATOM
6076
CE
LYS
A
1078
103.714
38.514
88.764
1.00
45.63
6

ATOM
6077
NZ
LYS
A
1078
104.653
37.754
87.896
1.00
47.98
7

ATOM
6078
C
LYS
A
1078
99.290
36.729
92.057
1.00
38.89
6

ATOM
6079
O
LYS
A
1078
99.676
37.266
93.083
1.00
38.69
8

ATOM
6080
N
GLY
A
1079
98.078
36.210
91.912
1.00
38.84
7

ATOM
6081
CA
GLY
A
1079
97.113
36.300
92.992
1.00
37.39
6

ATOM
6082
C
GLY
A
1079
96.844
37.741
93.394
1.00
39.24
6

ATOM
6083
O
GLY
A
1079
96.518
38.568
92.543
1.00
37.02
8

ATOM
6084
N
TRP
A
1080
96.995
38.041
94.685
1.00
39.16
7

ATOM
6085
CA
TRP
A
1080
96.764
39.380
95.226
1.00
40.17
6

ATOM
6086
CB
TRP
A
1080
96.129
39.284
96.617
1.00
40.13
6

ATOM
6087
CG
TRP
A
1080
94.760
38.715
96.631
1.00
42.16
6

ATOM
6088
CD2
TRP
A
1080
93.550
39.392
96.271
1.00
41.45
6

ATOM
6089
CE2
TRP
A
1080
92.492
38.468
96.424
1.00
43.14
6

ATOM
6090
CE3
TRP
A
1080
93.258
40.693
95.834
1.00
39.85
6

ATOM
6091
CD1
TRP
A
1080
94.401
37.443
96.978
1.00
43.22
6

ATOM
6092
NE1
TRP
A
1080
93.039
37.287
96.857
1.00
44.87
7

ATOM
6093
CZ2
TRP
A
1080
91.158
38.803
96.155
1.00
42.58
6

ATOM
6094
CZ3
TRP
A
1080
91.931
41.026
95.567
1.00
41.26
6

ATOM
6095
CH2
TRP
A
1080
90.898
40.081
95.729
1.00
41.20
6

ATOM
6096
C
TRP
A
1080
98.011
40.253
95.352
1.00
40.97
6

ATOM
6097
O
TRP
A
1080
97.914
41.415
95.764
1.00
41.95
8

ATOM
6098
N
THR
A
1081
99.171
39.702
95.010
1.00
39.61
7

ATOM
6099
CA
THR
A
1081
100.443
40.411
95.139
1.00
39.96
6

ATOM
6100
CB
THR
A
1081
101.584
39.598
94.511
1.00
41.50
6

ATOM
6101
OG1
THR
A
1081
101.682
38.333
95.176
1.00
45.76
8

ATOM
6102
CG2
THR
A
1081
102.913
40.338
94.649
1.00
44.46
6

ATOM
6103
C
THR
A
1081
100.514
41.832
94.583
1.00
40.96
6

ATOM
6104
O
THR
A
1081
100.896
42.765
95.296
1.00
41.20
8

ATOM
6105
N
VAL
A
1082
100.226
41.963
93.280
1.00
39.00
7

ATOM
6106
CA
VAL
A
1082
100.304
43.273
92.576
1.00
38.03
6

ATOM
6107
CB
VAL
A
1082
100.057
43.175
91.054
1.00
37.74
6

ATOM
6108
CG1
VAL
A
1082
100.322
44.511
90.378
1.00
36.04
6

ATOM
6109
CG2
VAL
A
1082
100.918
42.097
90.428
1.00
38.72
6

ATOM
6110
C
VAL
A
1082
99.275
44.207
93.066
1.00
38.08
6

ATOM
6111
O
VAL
A
1082
99.370
45.431
92.928
1.00
38.62
8

ATOM
6112
N
GLN
A
1083
98.286
43.636
93.641
1.00
38.04
7

ATOM
6113
CA
GLN
A
1083
97.244
44.439
94.154
1.00
37.09
6

ATOM
6114
CB
GLN
A
1083
95.927
43.682
94.113
1.00
36.47
6

ATOM
6115
CG
GLN
A
1083
94.999
44.199
93.063
1.00
35.34
6

ATOM
6116
CD
GLN
A
1083
93.900
45.001
93.687
1.00
35.22
6

ATOM
6117
OE1
GLN
A
1083
93.037
44.457
94.378
1.00
34.15
8

ATOM
6118
NE2
GLN
A
1083
93.734
46.302
93.584
1.00
29.69
7

ATOM
6119
C
GLN
A
1083
97.596
44.822
95.540
1.00
38.53
6

ATOM
6120
O
GLN
A
1083
97.444
45.985
95.904
1.00
37.03
8

ATOM
6121
N
PHE
A
1084
98.016
43.904
96.366
1.00
39.01
7

ATOM
6122
CA
PHE
A
1084
98.146
44.500
97.657
1.00
39.76
6

ATOM
6123
CB
PHE
A
1084
97.706
43.538
98.718
1.00
40.27
6

ATOM
6124
CG
PHE
A
1084
96.213
43.639
98.633
1.00
41.71
6

ATOM
6125
CD1
PHE
A
1084
95.505
42.680
97.942
1.00
40.19
6

ATOM
6126
CD2
PHE
A
1084
95.491
44.665
99.213
1.00
41.95
6

ATOM
6127
CE1
PHE
A
1084
94.127
42.744
97.832
1.00
42.13
6

ATOM
6128
CE2
PHE
A
1084
94.114
44.736
99.107
1.00
44.15
6

ATOM
6129
CZ
PHE
A
1084
93.415
43.774
98.416
1.00
41.24
6

ATOM
6130
C
PHE
A
1084
99.454
44.961
97.091
1.00
39.61
6

ATOM
6131
O
PHE
A
1084
99.726
44.700
95.913
1.00
39.02
8

ATOM
1
N
MET
B
201
53.741
61.791
99.131
1.00
51.28
7

ATOM
2
CA
MET
B
201
52.634
61.051
98.538
1.00
49.44
6

ATOM
3
C
MET
B
201
53.048
59.630
98.181
1.00
48.28
6

ATOM
4
O
MET
B
201
53.509
59.310
97.087
1.00
47.77
8

ATOM
5
CB
MET
B
201
52.101
61.744
97.303
1.00
50.50
6

ATOM
6
CG
MET
B
201
50.898
61.022
96.725
1.00
49.84
6

ATOM
7
SD
MET
B
201
50.316
61.763
95.202
1.00
49.51
16

ATOM
8
CE
MET
B
201
51.580
61.223
94.047
1.00
48.52
6

ATOM
9
N
THR
B
202
52.865
58.871
99.251
1.00
46.28
7

ATOM
10
CA
THR
B
202
53.086
57.459
99.345
1.00
45.23
6

ATOM
11
C
THR
B
202
52.490
56.806
98.123
1.00
43.28
6

ATOM
12
O
THR
B
202
51.377
57.141
97.702
1.00
40.67
8

ATOM
13
CB
THR
B
202
52.513
56.963
100.671
1.00
47.20
6

ATOM
14
OG1
THR
B
202
53.005
57.777
101.737
1.00
48.61
8

ATOM
15
CG2
THR
B
202
52.927
55.520
100.910
1.00
49.33
6

ATOM
16
N
GLU
B
203
53.254
55.872
97.573
1.00
41.53
7

ATOM
17
CA
GLU
B
203
52.875
55.192
96.330
1.00
38.67
6

ATOM
18
C
GLU
B
203
52.593
53.698
96.478
1.00
36.51
6

ATOM
19
O
GLU
B
203
53.359
52.967
97.117
1.00
35.10
8

ATOM
20
CB
GLU
B
203
53.985
55.452
95.313
1.00
38.84
6

ATOM
21
CG
GLU
B
203
53.722
54.907
93.932
1.00
42.79
6

ATOM
22
CD
GLU
B
203
54.829
55.235
92.936
1.00
44.78
6

ATOM
23
OE1
GLU
B
203
54.897
56.379
92.469
1.00
47.37
8

ATOM
24
OE2
GLU
B
203
55.617
54.314
92.635
1.00
46.62
8

ATOM
25
N
TYR
B
204
51.500
53.242
95.897
1.00
33.91
7

ATOM
26
CA
TYR
B
204
51.068
51.858
96.006
1.00
30.69
6

ATOM
27
C
TYR
B
204
51.101
51.162
94.640
1.00
28.79
6

ATOM
28
O
TYR
B
204
50.511
51.648
93.673
1.00
26.78
8

ATOM
29
CB
TYR
B
204
49.657
51.786
96.586
1.00
29.61
6

ATOM
30
CG
TYR
B
204
49.562
52.203
98.025
1.00
29.85
6

ATOM
31
CD1
TYR
B
204
50.030
51.392
99.060
1.00
31.05
6

ATOM
32
CD2
TYR
B
204
48.981
53.422
98.358
1.00
29.42
6

ATOM
33
CE1
TYR
B
204
49.918
51.784
100.391
1.00
29.72
6

ATOM
34
CE2
TYR
B
204
48.863
53.823
99.686
1.00
30.69
6

ATOM
35
CZ
TYR
B
204
49.332
52.998
100.696
1.00
31.20
6

ATOM
36
OH
TYR
B
204
49.225
53.408
102.011
1.00
35.67
8

ATOM
37
N
LYS
B
205
51.784
50.024
94.565
1.00
27.93
7

ATOM
38
CA
LYS
B
205
51.901
49.281
93.322
1.00
24.68
6

ATOM
39
C
LYS
B
205
50.954
48.089
93.314
1.00
21.57
6

ATOM
40
O
LYS
B
205
51.240
47.043
93.904
1.00
20.12
8

ATOM
41
CB
LYS
B
205
53.347
48.840
93.105
1.00
28.19
6

ATOM
42
CG
LYS
B
205
54.331
49.995
93.001
1.00
34.48
6

ATOM
43
CD
LYS
B
205
55.704
49.514
92.564
1.00
40.70
6

ATOM
44
CE
LYS
B
205
56.688
50.669
92.467
1.00
43.84
6

ATOM
45
NZ
LYS
B
205
58.037
50.215
92.034
1.00
49.59
7

ATOM
46
N
LEU
B
206
49.808
48.278
92.659
1.00
18.65
7

ATOM
47
CA
LEU
B
206
48.776
47.255
92.538
1.00
15.19
6

ATOM
48
C
LEU
B
206
48.889
46.505
91.215
1.00
14.14
6

ATOM
49
O
LEU
B
206
49.223
47.089
90.181
1.00
10.75
8

ATOM
50
CB
LEU
B
206
47.380
47.883
92.635
1.00
13.89
6

ATOM
51
CG
LEU
B
206
46.923
48.491
93.964
1.00
18.13
6

ATOM
52
CD1
LEU
B
206
47.699
49.747
94.263
1.00
14.35
6

ATOM
53
CD2
LEU
B
206
45.437
48.810
93.905
1.00
17.76
6

ATOM
54
N
VAL
B
207
48.609
45.206
91.259
1.00
11.52
7

ATOM
55
CA
VAL
B
207
48.658
44.370
90.068
1.00
11.37
6

ATOM
56
C
VAL
B
207
47.338
43.609
89.930
1.00
11.18
6

ATOM
57
O
VAL
B
207
46.879
42.960
90.875
1.00
9.73
8

ATOM
58
CB
VAL
B
207
49.841
43.363
90.124
1.00
11.42
6

ATOM
59
CG1
VAL
B
207
49.956
42.606
88.794
1.00
8.29
6

ATOM
60
CG2
VAL
B
207
51.147
44.095
90.418
1.00
8.29
6

ATOM
61
N
VAL
B
208
46.718
43.732
88.759
1.00
10.37
7

ATOM
62
CA
VAL
B
208
45.448
43.063
88.478
1.00
9.27
6

ATOM
63
C
VAL
B
208
45.743
41.787
87.692
1.00
11.11
6

ATOM
64
O
VAL
B
208
46.208
41.842
86.546
1.00
11.80
8

ATOM
65
CB
VAL
B
208
44.495
43.971
87.664
1.00
6.10
6

ATOM
66
CG1
VAL
B
208
43.099
43.378
87.625
1.00
4.20
6

ATOM
67
CG2
VAL
B
208
44.460
45.370
88.268
1.00
8.22
6

ATOM
68
N
VAL
B
209
45.489
40.643
88.324
1.00
9.18
7

ATOM
69
CA
VAL
B
209
45.743
39.341
87.713
1.00
9.00
6

ATOM
70
C
VAL
B
209
44.486
38.479
87.566
1.00
8.88
6

ATOM
71
O
VAL
B
209
43.485
38.696
88.246
1.00
6.64
8

ATOM
72
CB
VAL
B
209
46.802
38.545
88.518
1.00
6.04
6

ATOM
73
CG1
VAL
B
209
48.118
39.303
88.555
1.00
4.79
6

ATOM
74
CG2
VAL
B
209
46.308
38.283
89.925
1.00
2.58
6

ATOM
75
N
GLY
B
210
44.557
37.499
86.667
1.00
8.62
7

ATOM
76
CA
GLY
B
210
43.434
36.607
86.432
1.00
7.31
6

ATOM
77
C
GLY
B
210
43.402
36.110
85.000
1.00
6.94
6

ATOM
78
O
GLY
B
210
44.090
36.653
84.134
1.00
4.02
8

ATOM
79
N
ALA
B
211
42.596
35.082
84.748
1.00
7.14
7

ATOM
80
CA
ALA
B
211
42.469
34.492
83.417
1.00
7.36
6

ATOM
81
C
ALA
B
211
41.976
35.496
82.377
1.00
7.24
6

ATOM
82
O
ALA
B
211
41.410
36.537
82.715
1.00
8.46
8

ATOM
83
CB
ALA
B
211
41.538
33.276
83.465
1.00
6.62
6

ATOM
84
N
VAL
B
212
42.166
35.163
81.110
1.00
8.63
7

ATOM
85
CA
VAL
B
212
41.794
36.049
80.012
1.00
7.16
6

ATOM
86
C
VAL
B
212
40.275
36.231
79.957
1.00
7.92
6

ATOM
87
O
VAL
B
212
39.495
35.315
80.156
1.00
6.09
8

ATOM
88
CB
VAL
B
212
42.326
35.521
78.665
1.00
20.00
6

ATOM
89
CG1
VAL
B
212
41.635
34.217
78.293
1.00
20.00
6

ATOM
90
CG2
VAL
B
212
42.143
36.561
77.571
1.00
20.00
6

ATOM
91
N
GLY
B
213
39.886
37.485
79.674
1.00
9.19
7

ATOM
92
CA
GLY
B
213
38.482
37.829
79.530
1.00
8.57
6

ATOM
93
C
GLY
B
213
37.641
38.012
80.777
1.00
8.47
6

ATOM
94
O
GLY
B
213
36.440
38.265
80.665
1.00
9.56
8

ATOM
95
N
VAL
B
214
38.243
37.906
81.959
1.00
7.99
7

ATOM
96
CA
VAL
B
214
37.446
38.064
83.199
1.00
6.82
6

ATOM
97
C
VAL
B
214
37.057
39.503
83.510
1.00
8.46
6

ATOM
98
O
VAL
B
214
36.145
39.725
84.301
1.00
6.80
8

ATOM
99
CB
VAL
B
214
38.208
37.438
84.413
1.00
7.50
6

ATOM
100
CG1
VAL
B
214
38.415
35.957
84.202
1.00
5.57
6

ATOM
101
CG2
VAL
B
214
39.542
38.140
84.615
1.00
3.32
6

ATOM
102
N
GLY
B
215
37.731
40.472
82.924
1.00
7.60
7

ATOM
103
CA
GLY
B
215
37.397
41.867
83.155
1.00
6.99
6

ATOM
104
C
GLY
B
215
38.514
42.649
83.857
1.00
8.79
6

ATOM
105
O
GLY
B
215
38.246
43.636
84.539
1.00
10.93
8

ATOM
106
N
LYS
B
216
39.793
42.224
83.683
1.00
9.81
7

ATOM
107
CA
LYS
B
216
40.923
42.926
84.323
1.00
10.11
6

ATOM
108
C
LYS
B
216
40.985
44.404
83.943
1.00
9.57
6

ATOM
109
O
LYS
B
216
40.910
45.308
84.780
1.00
7.71
8

ATOM
110
CB
LYS
B
216
42.248
42.278
83.939
1.00
8.73
6

ATOM
111
CG
LYS
B
216
42.284
40.775
84.096
1.00
12.18
6

ATOM
112
CD
LYS
B
216
43.267
40.133
83.119
1.00
12.29
6

ATOM
113
CE
LYS
B
216
43.812
38.812
83.665
1.00
11.54
6

ATOM
114
NZ
LYS
B
216
43.286
37.637
82.914
1.00
11.90
7

ATOM
115
N
SER
B
217
41.110
44.600
82.629
1.00
8.65
7

ATOM
116
CA
SER
B
217
41.196
45.880
81.944
1.00
8.85
6

ATOM
117
C
SER
B
217
39.975
46.747
82.198
1.00
7.85
6

ATOM
118
O
SER
B
217
40.098
47.924
82.523
1.00
9.51
8

ATOM
119
CB
SER
B
217
41.370
45.677
80.435
1.00
9.24
6

ATOM
120
OG
SER
B
217
42.533
44.926
80.161
1.00
9.51
8

ATOM
121
N
ALA
B
218
38.797
46.151
82.058
1.00
7.69
7

ATOM
122
CA
ALA
B
218
37.542
46.861
82.279
1.00
9.30
6

ATOM
123
C
ALA
B
218
37.498
47.439
83.692
1.00
9.53
6

ATOM
124
O
ALA
B
218
37.121
48.598
83.884
1.00
11.33
8

ATOM
125
CB
ALA
B
218
36.370
45.928
82.056
1.00
4.97
6

ATOM
126
N
LEU
B
219
37.907
46.625
84.665
1.00
8.11
7

ATOM
127
CA
LEU
B
219
37.948
46.996
86.081
1.00
8.83
6

ATOM
128
C
LEU
B
219
38.904
48.163
86.307
1.00
9.77
6

ATOM
129
O
LEU
B
219
38.546
49.164
86.931
1.00
9.84
8

ATOM
130
CB
LEU
B
219
38.401
45.788
86.904
1.00
7.47
6

ATOM
131
CG
LEU
B
219
37.569
45.312
88.095
1.00
13.16
6

ATOM
132
CD1
LEU
B
219
36.088
45.532
87.861
1.00
8.63
6

ATOM
133
CD2
LEU
B
219
37.864
43.838
88.354
1.00
10.01
6

ATOM
134
N
THR
B
220
40.112
48.035
85.765
1.00
9.83
7

ATOM
135
CA
THR
B
220
41.146
49.058
85.893
1.00
6.71
6

ATOM
136
C
THR
B
220
40.708
50.380
85.263
1.00
9.11
6

ATOM
137
O
THR
B
220
40.793
51.437
85.891
1.00
7.07
8

ATOM
138
CB
THR
B
220
42.454
48.596
85.234
1.00
9.38
6

ATOM
139
OG1
THR
B
220
42.893
47.377
85.847
1.00
7.13
8

ATOM
140
CG2
THR
B
220
43.537
49.662
85.384
1.00
7.15
6

ATOM
141
N
ILE
B
221
40.231
50.309
84.023
1.00
10.23
7

ATOM
142
CA
ILE
B
221
39.772
51.486
83.294
1.00
11.37
6

ATOM
143
C
ILE
B
221
38.581
52.150
83.982
1.00
13.77
6

ATOM
144
O
ILE
B
221
38.449
53.372
83.950
1.00
17.70
8

ATOM
145
CB
ILE
B
221
39.432
51.116
81.835
1.00
11.83
6

ATOM
146
CG1
ILE
B
221
40.721
50.742
81.092
1.00
9.78
6

ATOM
147
CG2
ILE
B
221
38.712
52.264
81.138
1.00
13.38
6

ATOM
148
CD1
ILE
B
221
40.506
49.908
79.851
1.00
13.87
6

ATOM
149
N
GLN
B
222
37.723
51.351
84.609
1.00
13.58
7

ATOM
150
CA
GLN
B
222
36.567
51.892
85.312
1.00
14.08
6

ATOM
151
C
GLN
B
222
37.041
52.745
86.485
1.00
16.48
6

ATOM
152
O
GLN
B
222
36.529
53.841
86.712
1.00
16.85
8

ATOM
153
CB
GLN
B
222
35.660
50.768
85.815
1.00
14.15
6

ATOM
154
CG
GLN
B
222
34.392
51.245
86.520
1.00
15.60
6

ATOM
155
CD
GLN
B
222
33.469
52.070
85.626
1.00
16.95
6

ATOM
156
OE1
GLN
B
222
33.520
53.299
85.634
1.00
16.90
8

ATOM
157
NE2
GLN
B
222
32.602
51.395
84.876
1.00
14.47
7

ATOM
158
N
LEU
B
223
38.057
52.260
87.193
1.00
17.36
7

ATOM
159
CA
LEU
B
223
38.609
52.975
88.342
1.00
18.18
6

ATOM
160
C
LEU
B
223
39.400
54.222
87.914
1.00
17.63
6

ATOM
161
O
LEU
B
223
39.193
55.312
88.440
1.00
19.17
8

ATOM
162
CB
LEU
B
223
39.513
52.050
89.162
1.00
17.42
6

ATOM
163
CG
LEU
B
223
40.070
52.699
90.430
1.00
20.15
6

ATOM
164
CD1
LEU
B
223
39.113
52.514
91.599
1.00
18.81
6

ATOM
165
CD2
LEU
B
223
41.449
52.150
90.769
1.00
18.18
6

ATOM
166
N
ILE
B
224
40.312
54.047
86.929
1.00
17.04
7

ATOM
167
CA
ILE
B
224
41.167
55.164
86.495
1.00
16.09
6

ATOM
168
C
ILE
B
224
40.386
56.265
85.727
1.00
19.03
6

ATOM
169
O
ILE
B
224
40.615
57.431
85.994
1.00
18.33
8

ATOM
170
CB
ILE
B
224
42.384
54.616
85.724
1.00
16.45
6

ATOM
171
CG1
ILE
B
224
43.125
53.589
86.589
1.00
15.55
6

ATOM
172
CG2
ILE
B
224
43.323
55.752
85.324
1.00
13.57
6

ATOM
173
CD1
ILE
B
224
43.833
54.198
87.782
1.00
17.84
6

ATOM
174
N
GLN
B
225
39.488
55.925
84.770
1.00
18.73
7

ATOM
175
CA
GLN
B
225
38.731
56.946
83.983
1.00
20.33
6

ATOM
176
C
GLN
B
225
37.269
57.034
84.397
1.00
21.59
6

ATOM
177
O
GLN
B
225
36.701
58.126
84.358
1.00
19.80
8

ATOM
178
CB
GLN
B
225
38.784
56.642
82.446
1.00
20.16
6

ATOM
179
CG
GLN
B
225
39.711
57.525
81.585
1.00
20.02
6

ATOM
180
CD
GLN
B
225
39.427
57.507
80.079
1.00
22.47
6

ATOM
181
OE1
GLN
B
225
38.362
57.048
79.638
1.00
24.08
8

ATOM
182
NE2
GLN
B
225
40.235
57.943
79.134
1.00
22.96
7

ATOM
183
N
ASN
B
226
36.660
55.953
84.791
1.00
24.10
7

ATOM
184
CA
ASN
B
226
35.275
56.144
85.062
1.00
28.68
6

ATOM
185
C
ASN
B
226
34.582
55.986
83.737
1.00
31.72
6

ATOM
186
O
ASN
B
226
34.201
56.952
83.074
1.00
33.20
8

ATOM
187
CB
ASN
B
226
35.009
57.539
85.626
1.00
33.17
6

ATOM
188
CG
ASN
B
226
33.643
57.609
86.225
1.00
39.89
6

ATOM
189
OD1
ASN
B
226
33.396
58.439
87.108
1.00
42.01
8

ATOM
190
ND2
ASN
B
226
32.731
56.741
85.771
1.00
41.16
7

ATOM
191
N
HIS
B
227
34.424
54.757
83.380
1.00
30.85
7

ATOM
192
CA
HIS
B
227
33.788
54.490
82.161
1.00
29.41
6

ATOM
193
C
HIS
B
227
34.030
53.072
81.755
1.00
26.28
6

ATOM
194
O
HIS
B
227
35.033
52.448
82.110
1.00
21.97
8

ATOM
195
CB
HIS
B
227
34.215
55.533
81.131
1.00
32.75
6

ATOM
196
CG
HIS
B
227
34.911
54.992
79.861
1.00
36.45
6

ATOM
197
ND1
HIS
B
227
34.213
54.660
78.718
1.00
39.88
7

ATOM
198
CD2
HIS
B
227
36.218
54.790
79.574
1.00
38.48
6

ATOM
199
CE1
HIS
B
227
35.064
54.275
77.783
1.00
41.01
6

ATOM
200
NE2
HIS
B
227
36.286
54.345
78.276
1.00
39.45
7

ATOM
201
N
PHE
B
228
33.014
52.585
81.002
1.00
23.47
7

ATOM
202
CA
PHE
B
228
33.007
51.207
80.562
1.00
22.82
6

ATOM
203
C
PHE
B
228
32.696
50.960
79.113
1.00
24.50
6

ATOM
204
O
PHE
B
228
31.753
51.424
78.477
1.00
26.79
8

ATOM
205
CB
PHE
B
228
32.097
50.400
81.445
1.00
19.66
6

ATOM
206
CG
PHE
B
228
31.927
48.995
80.923
1.00
14.82
6

ATOM
207
CD1
PHE
B
228
30.879
48.716
80.082
1.00
15.86
6

ATOM
208
CD2
PHE
B
228
32.815
47.987
81.271
1.00
14.34
6

ATOM
209
CE1
PHE
B
228
30.663
47.452
79.593
1.00
9.36
6

ATOM
210
CE2
PHE
B
228
32.608
46.693
80.789
1.00
11.60
6

ATOM
211
CZ
PHE
B
228
31.526
46.428
79.946
1.00
10.60
6

ATOM
212
N
VAL
B
229
33.616
50.157
78.732
1.00
25.32
7

ATOM
213
CA
VAL
B
229
33.873
49.609
77.453
1.00
27.53
6

ATOM
214
C
VAL
B
229
33.023
48.483
77.082
1.00
28.42
6

ATOM
215
O
VAL
B
229
32.510
47.733
77.906
1.00
28.15
8

ATOM
216
CB
VAL
B
229
35.272
48.949
77.470
1.00
28.47
6

ATOM
217
CG1
VAL
B
229
36.332
49.936
77.936
1.00
27.03
6

ATOM
218
CG2
VAL
B
229
35.251
47.728
78.383
1.00
31.22
6

ATOM
219
N
ASP
B
230
32.890
48.367
75.835
1.00
27.38
7

ATOM
220
CA
ASP
B
230
32.314
47.180
75.402
1.00
27.07
6

ATOM
221
C
ASP
B
230
33.231
46.783
74.361
1.00
25.75
6

ATOM
222
O
ASP
B
230
33.062
47.165
73.205
1.00
25.41
8

ATOM
223
CB
ASP
B
230
30.926
47.257
74.843
1.00
29.51
6

ATOM
224
CG
ASP
B
230
30.433
45.812
74.766
1.00
32.34
6

ATOM
225
OD1
ASP
B
230
30.808
45.094
73.819
1.00
37.01
8

ATOM
226
OD2
ASP
B
230
29.674
45.409
75.657
1.00
37.81
8

ATOM
227
N
GLU
B
231
34.211
46.049
74.704
1.00
24.23
7

ATOM
228
CA
GLU
B
231
35.011
45.751
73.584
1.00
21.88
6

ATOM
229
C
GLU
B
231
36.034
44.814
73.923
1.00
20.00
6

ATOM
230
O
GLU
B
231
36.269
44.426
75.061
1.00
19.03
8

ATOM
231
CB
GLU
B
231
35.685
46.971
73.009
1.00
23.67
6

ATOM
232
CG
GLU
B
231
34.894
48.247
73.159
1.00
28.14
6

ATOM
233
CD
GLU
B
231
35.658
49.442
72.604
1.00
33.02
6

ATOM
234
OE1
GLU
B
231
36.906
49.378
72.547
1.00
20.00
8

ATOM
235
OE2
GLU
B
231
35.009
50.427
72.218
1.00
20.00
8

ATOM
236
N
TYR
B
232
36.666
44.368
72.924
1.00
17.58
7

ATOM
237
CA
TYR
B
232
37.616
43.481
73.357
1.00
15.09
6

ATOM
238
C
TYR
B
232
38.871
43.648
72.639
1.00
14.72
6

ATOM
239
O
TYR
B
232
39.037
43.446
71.431
1.00
13.19
8

ATOM
240
CB
TYR
B
232
37.020
42.137
73.413
1.00
15.62
6

ATOM
241
CG
TYR
B
232
37.999
41.319
74.146
1.00
15.84
6

ATOM
242
CD1
TYR
B
232
38.312
40.117
73.588
1.00
16.94
6

ATOM
243
CD2
TYR
B
232
38.626
41.729
75.316
1.00
18.16
6

ATOM
244
CE1
TYR
B
232
39.188
39.283
74.186
1.00
14.73
6

ATOM
245
CE2
TYR
B
232
39.531
40.903
75.925
1.00
16.00
6

ATOM
246
CZ
TYR
B
232
39.788
39.685
75.357
1.00
15.50
6

ATOM
247
OH
TYR
B
232
40.689
38.837
75.968
1.00
15.37
8

ATOM
248
N
ASP
B
233
39.762
44.057
73.501
1.00
14.46
7

ATOM
249
CA
ASP
B
233
41.066
44.495
73.172
1.00
13.56
6

ATOM
250
C
ASP
B
233
42.138
43.998
74.132
1.00
11.24
6

ATOM
251
O
ASP
B
233
42.402
44.539
75.213
1.00
10.70
8

ATOM
252
CB
ASP
B
233
40.938
46.009
73.048
1.00
13.01
6

ATOM
253
CG
ASP
B
233
42.210
46.800
72.901
1.00
15.77
6

ATOM
254
OD1
ASP
B
233
43.211
46.233
72.406
1.00
19.40
8

ATOM
255
OD2
ASP
B
233
42.214
47.985
73.288
1.00
17.35
8

ATOM
256
N
PRO
B
234
42.709
42.911
73.629
1.00
10.67
7

ATOM
257
CA
PRO
B
234
43.742
42.168
74.324
1.00
8.90
6

ATOM
258
C
PRO
B
234
44.865
42.970
74.873
1.00
9.38
6

ATOM
259
O
PRO
B
234
45.531
43.817
74.274
1.00
7.82
8

ATOM
260
CB
PRO
B
234
44.032
41.004
73.389
1.00
11.52
6

ATOM
261
CG
PRO
B
234
42.672
40.705
72.876
1.00
8.85
6

ATOM
262
CD
PRO
B
234
41.833
41.948
72.936
1.00
8.82
6

ATOM
263
N
THR
B
235
45.004
42.584
76.094
1.00
9.48
7

ATOM
264
CA
THR
B
235
45.897
43.076
77.061
1.00
8.60
6

ATOM
265
C
THR
B
235
47.251
42.320
77.106
1.00
8.10
6

ATOM
266
O
THR
B
235
47.284
41.166
77.517
1.00
9.36
8

ATOM
267
CB
THR
B
235
45.176
42.960
78.394
1.00
6.31
6

ATOM
268
OG1
THR
B
235
43.767
43.206
78.195
1.00
7.96
8

ATOM
269
CG2
THR
B
235
45.743
43.964
79.390
1.00
2.14
6

ATOM
270
N
ILE
B
236
48.346
42.945
76.689
1.00
7.23
7

ATOM
271
CA
ILE
B
236
49.693
42.326
76.803
1.00
7.94
6

ATOM
272
C
ILE
B
236
50.250
42.697
78.184
1.00
9.45
6

ATOM
273
O
ILE
B
236
50.585
41.852
78.999
1.00
9.93
8

ATOM
274
CB
ILE
B
236
50.684
42.852
75.730
1.00
6.39
6

ATOM
275
CG1
ILE
B
236
50.356
42.274
74.349
1.00
6.36
6

ATOM
276
CG2
ILE
B
236
52.129
42.515
76.106
1.00
6.69
6

ATOM
277
CD1
ILE
B
236
51.337
42.672
73.276
1.00
10.80
6

ATOM
278
N
GLU
B
237
50.305
44.018
78.405
1.00
9.32
7

ATOM
279
CA
GLU
B
237
50.707
44.640
79.644
1.00
10.29
6

ATOM
280
C
GLU
B
237
50.503
46.147
79.579
1.00
10.56
6

ATOM
281
O
GLU
B
237
51.213
46.838
78.857
1.00
11.70
8

ATOM
282
CB
GLU
B
237
52.162
44.329
80.023
1.00
11.79
6

ATOM
283
CG
GLU
B
237
52.516
44.886
81.406
1.00
17.72
6

ATOM
284
CD
GLU
B
237
54.008
44.980
81.676
1.00
17.71
6

ATOM
285
OE1
GLU
B
237
54.689
45.839
81.050
1.00
22.77
8

ATOM
286
OE2
GLU
B
237
54.497
44.194
82.509
1.00
18.09
8

ATOM
287
N
ASP
B
238
49.536
46.621
80.340
1.00
12.33
7

ATOM
288
CA
ASP
B
238
49.255
48.057
80.374
1.00
11.37
6

ATOM
289
C
ASP
B
238
49.496
48.571
81.773
1.00
12.68
6

ATOM
290
O
ASP
B
238
49.258
47.866
82.763
1.00
13.32
8

ATOM
291
CB
ASP
B
238
47.808
48.365
79.962
1.00
12.06
6

ATOM
292
CG
ASP
B
238
47.483
47.852
78.575
1.00
14.27
6

ATOM
293
OD1
ASP
B
238
48.417
47.599
77.781
1.00
10.32
8

ATOM
294
OD2
ASP
B
238
46.280
47.711
78.276
1.00
14.55
8

ATOM
295
N
SER
B
239
49.956
49.789
81.873
1.00
12.94
7

ATOM
296
CA
SER
B
239
50.161
50.386
83.192
1.00
13.42
6

ATOM
297
C
SER
B
239
49.141
51.528
83.408
1.00
12.55
6

ATOM
298
O
SER
B
239
48.487
51.959
82.458
1.00
12.18
8

ATOM
299
CB
SER
B
239
51.595
50.882
83.343
1.00
15.17
6

ATOM
300
OG
SER
B
239
51.641
52.269
83.617
1.00
18.45
8

ATOM
301
N
TYR
B
240
49.001
52.014
84.627
1.00
13.21
7

ATOM
302
CA
TYR
B
240
48.106
53.162
84.893
1.00
12.92
6

ATOM
303
C
TYR
B
240
48.606
53.768
86.193
1.00
16.77
6

ATOM
304
O
TYR
B
240
49.296
53.112
86.967
1.00
13.76
8

ATOM
305
CB
TYR
B
240
46.625
52.779
85.049
1.00
14.15
6

ATOM
306
CG
TYR
B
240
45.961
52.350
83.771
1.00
14.05
6

ATOM
307
CD1
TYR
B
240
46.029
51.017
83.369
1.00
14.29
6

ATOM
308
CD2
TYR
B
240
45.257
53.247
82.968
1.00
13.70
6

ATOM
309
CE1
TYR
B
240
45.411
50.589
82.200
1.00
13.77
6

ATOM
310
CE2
TYR
B
240
44.636
52.828
81.798
1.00
13.45
6

ATOM
311
CZ
TYR
B
240
44.717
51.500
81.422
1.00
12.96
6

ATOM
312
OH
TYR
B
240
44.103
51.084
80.270
1.00
15.08
8

ATOM
313
N
ARG
B
241
48.242
55.025
86.405
1.00
20.46
7

ATOM
314
CA
ARG
B
241
48.645
55.757
87.590
1.00
23.22
6

ATOM
315
C
ARG
B
241
47.620
56.851
87.864
1.00
24.40
6

ATOM
316
O
ARG
B
241
47.245
57.612
86.963
1.00
24.95
8

ATOM
317
CB
ARG
B
241
50.041
56.348
87.374
1.00
26.13
6

ATOM
318
CG
ARG
B
241
50.506
57.292
88.455
1.00
29.67
6

ATOM
319
CD
ARG
B
241
51.934
57.758
88.217
1.00
33.23
6

ATOM
320
NE
ARG
B
241
52.921
56.783
88.675
1.00
34.47
7

ATOM
321
CZ
ARG
B
241
54.224
57.031
88.773
1.00
35.55
6

ATOM
322
NH1
ARG
B
241
54.705
58.220
88.439
1.00
35.95
7

ATOM
323
NH2
ARG
B
241
55.042
56.100
89.213
1.00
37.97
7

ATOM
324
N
LYS
B
242
47.171
56.931
89.108
1.00
27.52
7

ATOM
325
CA
LYS
B
242
46.194
57.936
89.484
1.00
30.61
6

ATOM
326
C
LYS
B
242
46.335
58.174
90.961
1.00
30.89
6

ATOM
327
O
LYS
B
242
46.571
57.251
91.748
1.00
28.07
8

ATOM
328
CB
LYS
B
242
44.778
57.481
89.129
1.00
34.16
6

ATOM
329
CG
LYS
B
242
43.677
58.118
89.967
1.00
35.51
6

ATOM
330
CD
LYS
B
242
42.310
57.582
89.566
1.00
37.84
6

ATOM
331
CE
LYS
B
242
41.204
58.155
90.435
1.00
37.75
6

ATOM
332
NZ
LYS
B
242
39.878
57.578
90.081
1.00
38.94
7

ATOM
333
N
GLN
B
243
46.183
59.400
91.347
1.00
32.69
7

ATOM
334
CA
GLN
B
243
46.279
59.730
92.715
1.00
34.93
6

ATOM
335
C
GLN
B
243
44.880
59.812
93.251
1.00
34.91
6

ATOM
336
O
GLN
B
243
43.957
60.271
92.572
1.00
35.97
8

ATOM
337
CB
GLN
B
243
47.062
61.026
92.846
1.00
34.09
6

ATOM
338
CG
GLN
B
243
47.113
61.600
94.240
1.00
37.09
6

ATOM
339
CD
GLN
B
243
47.566
63.031
94.182
1.00
39.39
6

ATOM
340
OE1
GLN
B
243
48.654
63.322
93.681
1.00
40.63
8

ATOM
341
NE2
GLN
B
243
46.909
64.093
94.647
1.00
38.39
7

ATOM
342
N
VAL
B
244
44.718
59.373
94.468
1.00
36.59
7

ATOM
343
CA
VAL
B
244
43.406
59.393
95.009
1.00
37.18
6

ATOM
344
C
VAL
B
244
43.468
59.384
96.510
1.00
37.74
6

ATOM
345
O
VAL
B
244
44.535
59.262
97.102
1.00
37.52
8

ATOM
346
CB
VAL
B
244
42.616
58.214
94.435
1.00
36.95
6

ATOM
347
CG1
VAL
B
244
43.233
56.906
94.890
1.00
36.04
6

ATOM
348
CG2
VAL
B
244
41.155
58.302
94.859
1.00
38.56
6

ATOM
349
N
VAL
B
245
42.297
59.549
97.067
1.00
38.33
7

ATOM
350
CA
VAL
B
245
42.255
59.621
98.489
1.00
39.76
6

ATOM
351
C
VAL
B
245
41.666
58.402
99.084
1.00
39.05
6

ATOM
352
O
VAL
B
245
40.656
57.879
98.609
1.00
39.51
8

ATOM
353
CB
VAL
B
245
41.457
60.864
98.957
1.00
41.36
6

ATOM
354
CG1
VAL
B
245
42.155
62.143
98.540
1.00
42.45
6

ATOM
355
CG2
VAL
B
245
40.048
60.833
98.405
1.00
41.58
6

ATOM
356
N
ILE
B
246
42.306
57.977
100.102
1.00
38.11
7

ATOM
357
CA
ILE
B
246
41.716
56.887
100.765
1.00
36.88
6

ATOM
358
C
ILE
B
246
41.337
57.441
102.116
1.00
37.71
6

ATOM
359
O
ILE
B
246
41.021
58.623
102.232
1.00
37.36
8

ATOM
360
CB
ILE
B
246
42.671
55.676
100.801
1.00
35.21
6

ATOM
361
CG1
ILE
B
246
43.487
55.607
99.503
1.00
33.18
6

ATOM
362
CG2
ILE
B
246
41.899
54.373
101.002
1.00
33.95
6

ATOM
363
CD1
ILE
B
246
43.655
54.207
98.965
1.00
30.37
6

ATOM
364
N
ASP
B
247
41.379
56.618
103.113
1.00
39.08
7

ATOM
365
CA
ASP
B
247
41.026
57.135
104.414
1.00
41.19
6

ATOM
366
C
ASP
B
247
41.469
58.548
104.601
1.00
42.67
6

ATOM
367
O
ASP
B
247
40.801
59.325
105.294
1.00
42.85
8

ATOM
368
CB
ASP
B
247
41.542
56.191
105.454
1.00
39.66
6

ATOM
369
CG
ASP
B
247
40.996
54.849
105.034
1.00
39.63
6

ATOM
370
OD1
ASP
B
247
39.784
54.754
104.830
1.00
40.80
8

ATOM
371
OD2
ASP
B
247
41.776
53.879
104.907
1.00
40.43
8

ATOM
372
N
GLY
B
248
42.551
58.914
104.020
1.00
44.34
7

ATOM
373
CA
GLY
B
248
42.909
60.269
104.265
1.00
46.95
6

ATOM
374
C
GLY
B
248
44.380
60.455
104.122
1.00
47.75
6

ATOM
375
O
GLY
B
248
44.992
61.284
104.786
1.00
48.28
8

ATOM
376
N
GLU
B
249
44.951
59.682
103.217
1.00
49.39
7

ATOM
377
CA
GLU
B
249
46.376
59.722
102.912
1.00
50.74
6

ATOM
378
C
GLU
B
249
46.604
60.068
101.431
1.00
50.53
6

ATOM
379
O
GLU
B
249
47.463
59.438
100.813
1.00
50.71
8

ATOM
380
CB
GLU
B
249
47.005
58.321
103.151
1.00
52.59
6

ATOM
381
CG
GLU
B
249
46.708
57.275
102.054
1.00
58.27
6

ATOM
382
CD
GLU
B
249
46.776
55.798
102.452
1.00
60.54
6

ATOM
383
OE1
GLU
B
249
46.023
55.416
103.375
1.00
61.57
8

ATOM
384
OE2
GLU
B
249
47.566
55.042
101.858
1.00
62.66
8

ATOM
385
N
THR
B
250
45.896
61.021
100.823
1.00
49.93
7

ATOM
386
CA
THR
B
250
46.167
61.135
99.370
1.00
46.91
6

ATOM
387
C
THR
B
250
47.385
60.282
99.090
1.00
44.79
6

ATOM
388
O
THR
B
250
48.403
60.423
99.746
1.00
43.24
8

ATOM
389
CB
THR
B
250
46.410
62.567
98.871
1.00
48.41
6

ATOM
390
OG1
THR
B
250
45.225
63.364
99.052
1.00
47.77
8

ATOM
391
CG2
THR
B
250
46.810
62.543
97.406
1.00
49.37
6

ATOM
392
N
CYS
B
251
47.263
59.400
98.104
1.00
42.00
7

ATOM
393
CA
CYS
B
251
48.340
58.493
97.739
1.00
38.38
6

ATOM
394
C
CYS
B
251
48.362
58.246
96.231
1.00
35.09
6

ATOM
395
O
CYS
B
251
47.395
58.508
95.525
1.00
35.14
8

ATOM
396
CB
CYS
B
251
48.206
57.174
98.501
1.00
38.73
6

ATOM
397
SG
CYS
B
251
46.508
56.535
98.621
1.00
36.78
16

ATOM
398
N
LEU
B
252
49.484
57.734
95.740
1.00
31.83
7

ATOM
399
CA
LEU
B
252
49.646
57.458
94.322
1.00
32.24
6

ATOM
400
C
LEU
B
252
49.388
55.986
94.025
1.00
31.25
6

ATOM
401
O
LEU
B
252
50.054
55.110
94.580
1.00
30.93
8

ATOM
402
CB
LEU
B
252
51.064
57.819
93.876
1.00
34.14
6

ATOM
403
CG
LEU
B
252
51.216
58.582
92.561
1.00
34.96
6

ATOM
404
CD1
LEU
B
252
51.493
57.621
91.409
1.00
36.92
6

ATOM
405
CD2
LEU
B
252
49.983
59.431
92.281
1.00
33.48
6

ATOM
406
N
LEU
B
253
48.426
55.718
93.147
1.00
27.51
7

ATOM
407
CA
LEU
B
253
48.108
54.343
92.781
1.00
25.51
6

ATOM
408
C
LEU
B
253
48.688
53.947
91.432
1.00
23.87
6

ATOM
409
O
LEU
B
253
48.318
54.505
90.398
1.00
21.99
8

ATOM
410
CB
LEU
B
253
46.591
54.104
92.763
1.00
24.50
6

ATOM
411
CG
LEU
B
253
45.777
54.192
94.058
1.00
24.94
6

ATOM
412
CD1
LEU
B
253
44.410
53.570
93.822
1.00
23.95
6

ATOM
413
CD2
LEU
B
253
46.485
53.468
95.191
1.00
24.50
6

ATOM
414
N
ASP
B
254
49.642
53.023
91.457
1.00
23.18
7

ATOM
415
CA
ASP
B
254
50.248
52.506
90.234
1.00
22.76
6

ATOM
416
C
ASP
B
254
49.555
51.176
89.984
1.00
22.41
6

ATOM
417
O
ASP
B
254
49.613
50.275
90.826
1.00
23.13
8

ATOM
418
CB
ASP
B
254
51.753
52.279
90.413
1.00
27.20
6

ATOM
419
CG
ASP
B
254
52.553
53.572
90.386
1.00
29.86
6

ATOM
420
OD1
ASP
B
254
51.968
54.662
90.559
1.00
31.54
8

ATOM
421
OD2
ASP
B
254
53.783
53.490
90.187
1.00
32.40
8

ATOM
422
N
ILE
B
255
48.864
51.068
88.855
1.00
18.90
7

ATOM
423
CA
ILE
B
255
48.149
49.841
88.534
1.00
15.08
6

ATOM
424
C
ILE
B
255
48.683
49.146
87.298
1.00
12.73
6

ATOM
425
O
ILE
B
255
48.663
49.707
86.203
1.00
13.38
8

ATOM
426
CB
ILE
B
255
46.643
50.099
88.331
1.00
16.48
6

ATOM
427
CG1
ILE
B
255
46.047
50.763
89.578
1.00
18.10
6

ATOM
428
CG2
ILE
B
255
45.929
48.788
88.033
1.00
14.72
6

ATOM
429
CD1
ILE
B
255
44.552
51.013
89.495
1.00
21.51
6

ATOM
430
N
LEU
B
256
49.165
47.920
87.482
1.00
9.73
7

ATOM
431
CA
LEU
B
256
49.682
47.131
86.375
1.00
8.12
6

ATOM
432
C
LEU
B
256
48.586
46.164
85.930
1.00
7.21
6

ATOM
433
O
LEU
B
256
48.192
45.266
86.674
1.00
6.29
8

ATOM
434
CB
LEU
B
256
50.936
46.356
86.791
1.00
6.84
6

ATOM
435
CG
LEU
B
256
51.690
45.635
85.670
1.00
4.43
6

ATOM
436
CD1
LEU
B
256
52.229
46.653
84.682
1.00
6.66
6

ATOM
437
CD2
LEU
B
256
52.819
44.814
86.242
1.00
2.53
6

ATOM
438
N
ASP
B
257
48.052
46.412
84.738
1.00
7.21
7

ATOM
439
CA
ASP
B
257
46.998
45.594
84.145
1.00
7.45
6

ATOM
440
C
ASP
B
257
47.696
44.548
83.275
1.00
8.22
6

ATOM
441
O
ASP
B
257
48.224
44.860
82.205
1.00
8.74
8

ATOM
442
CB
ASP
B
257
46.073
46.504
83.329
1.00
8.70
6

ATOM
443
CG
ASP
B
257
44.950
45.753
82.657
1.00
9.50
6

ATOM
444
OD1
ASP
B
257
44.511
44.702
83.173
1.00
6.85
8

ATOM
445
OD2
ASP
B
257
44.508
46.236
81.596
1.00
10.23
8

ATOM
446
N
THR
B
258
47.699
43.308
83.756
1.00
10.11
7

ATOM
447
CA
THR
B
258
48.418
42.229
83.092
1.00
8.35
6

ATOM
448
C
THR
B
258
47.582
41.437
82.091
1.00
8.23
6

ATOM
449
O
THR
B
258
46.371
41.621
81.967
1.00
11.99
8

ATOM
450
CB
THR
B
258
48.989
41.243
84.142
1.00
8.13
6

ATOM
451
OG1
THR
B
258
47.908
40.502
84.744
1.00
6.51
8

ATOM
452
CG2
THR
B
258
49.759
42.007
85.204
1.00
2.22
6

ATOM
453
N
ALA
B
259
48.285
40.557
81.385
1.00
5.52
7

ATOM
454
CA
ALA
B
259
47.688
39.713
80.384
1.00
7.48
6

ATOM
455
C
ALA
B
259
47.105
38.476
80.990
1.00
9.19
6

ATOM
456
O
ALA
B
259
47.532
38.035
82.052
1.00
11.31
8

ATOM
457
CB
ALA
B
259
48.699
39.337
79.312
1.00
6.66
6

ATOM
458
N
GLY
B
260
46.125
37.902
80.346
1.00
9.72
7

ATOM
459
CA
GLY
B
260
45.586
36.662
80.807
1.00
11.00
6

ATOM
460
C
GLY
B
260
46.120
35.608
79.867
1.00
12.53
6

ATOM
461
O
GLY
B
260
46.256
34.439
80.207
1.00
13.43
8

ATOM
462
N
GLN
B
261
46.430
36.074
78.644
1.00
12.40
7

ATOM
463
CA
GLN
B
261
46.917
35.237
77.522
1.00
15.05
6

ATOM
464
C
GLN
B
261
48.180
34.429
77.861
1.00
15.70
6

ATOM
465
O
GLN
B
261
49.300
34.940
77.745
1.00
16.74
8

ATOM
466
CB
GLN
B
261
47.116
36.116
76.258
1.00
17.11
6

ATOM
467
CG
GLN
B
261
45.954
36.071
75.220
1.00
15.52
6

ATOM
468
CD
GLN
B
261
46.201
36.835
73.916
1.00
16.27
6

ATOM
469
OE1
GLN
B
261
46.262
36.235
72.832
1.00
16.77
8

ATOM
470
NE2
GLN
B
261
46.386
38.148
73.795
1.00
10.58
7

ATOM
471
N
GLU
B
262
47.959
33.140
78.307
1.00
15.37
7

ATOM
472
CA
GLU
B
262
49.081
32.279
78.657
1.00
18.10
6

ATOM
473
C
GLU
B
262
50.305
32.595
77.803
1.00
17.51
6

ATOM
474
O
GLU
B
262
51.428
32.313
78.142
1.00
18.72
8

ATOM
475
CB
GLU
B
262
48.692
30.807
78.513
1.00
19.14
6

ATOM
476
CG
GLU
B
262
47.535
30.383
79.401
1.00
24.07
6

ATOM
477
CD
GLU
B
262
47.995
29.842
80.741
1.00
25.10
6

ATOM
478
OE1
GLU
B
262
49.221
29.807
80.977
1.00
23.90
8

ATOM
479
OE2
GLU
B
262
47.130
29.454
81.554
1.00
28.42
8

ATOM
480
N
GLU
B
263
50.012
33.249
76.671
1.00
18.44
7

ATOM
481
CA
GLU
B
263
51.039
33.652
75.719
1.00
22.43
6

ATOM
482
C
GLU
B
263
52.074
34.558
76.376
1.00
23.64
6

ATOM
483
O
GLU
B
263
53.238
34.522
75.992
1.00
23.59
8

ATOM
484
CB
GLU
B
263
50.409
34.349
74.512
1.00
21.78
6

ATOM
485
CG
GLU
B
263
51.375
34.601
73.365
1.00
25.68
6

ATOM
486
CD
GLU
B
263
50.673
35.064
72.103
1.00
28.86
6

ATOM
487
OE1
GLU
B
263
49.432
35.202
72.130
1.00
25.25
8

ATOM
488
OE2
GLU
B
263
51.364
35.287
71.087
1.00
31.70
8

ATOM
489
N
TYR
B
264
51.656
35.348
77.330
1.00
25.75
7

ATOM
490
CA
TYR
B
264
52.595
36.244
77.976
1.00
28.14
6

ATOM
491
C
TYR
B
264
52.795
35.748
79.380
1.00
29.31
6

ATOM
492
O
TYR
B
264
52.692
36.465
80.375
1.00
32.38
8

ATOM
493
CB
TYR
B
264
52.060
37.679
77.965
1.00
26.09
6

ATOM
494
CG
TYR
B
264
51.618
38.064
76.572
1.00
25.37
6

ATOM
495
CD1
TYR
B
264
52.548
38.385
75.587
1.00
24.51
6

ATOM
496
CD2
TYR
B
264
50.269
38.057
76.228
1.00
27.35
6

ATOM
497
CE1
TYR
B
264
52.142
38.682
74.292
1.00
26.47
6

ATOM
498
CE2
TYR
B
264
49.857
38.353
74.939
1.00
27.67
6

ATOM
499
CZ
TYR
B
264
50.796
38.662
73.976
1.00
25.73
6

ATOM
500
OH
TYR
B
264
50.385
38.936
72.694
1.00
30.28
8

ATOM
501
N
SER
B
265
53.085
34.472
79.430
1.00
29.70
7

ATOM
502
CA
SER
B
265
53.271
33.818
80.697
1.00
29.71
6

ATOM
503
C
SER
B
265
54.618
34.108
81.316
1.00
30.48
6

ATOM
504
O
SER
B
265
54.808
33.947
82.531
1.00
30.50
8

ATOM
505
CB
SER
B
265
53.063
32.305
80.512
1.00
28.92
6

ATOM
506
OG
SER
B
265
52.070
32.030
79.530
1.00
30.09
8

ATOM
507
N
ALA
B
266
55.548
34.524
80.484
1.00
31.11
7

ATOM
508
CA
ALA
B
266
56.875
34.811
80.991
1.00
30.12
6

ATOM
509
C
ALA
B
266
57.068
36.260
81.413
1.00
29.72
6

ATOM
510
O
ALA
B
266
58.191
36.728
81.417
1.00
31.16
8

ATOM
511
CB
ALA
B
266
57.925
34.425
79.963
1.00
31.38
6

ATOM
512
N
MET
B
267
56.041
36.985
81.751
1.00
27.80
7

ATOM
513
CA
MET
B
267
56.268
38.359
82.176
1.00
24.41
6

ATOM
514
C
MET
B
267
55.636
38.516
83.520
1.00
22.53
6

ATOM
515
O
MET
B
267
55.717
39.543
84.187
1.00
20.93
8

ATOM
516
CB
MET
B
267
55.643
39.371
81.221
1.00
25.81
6

ATOM
517
CG
MET
B
267
55.983
39.137
79.776
1.00
27.94
6

ATOM
518
SD
MET
B
267
54.796
39.878
78.638
1.00
29.01
16

ATOM
519
CE
MET
B
267
55.268
41.606
78.718
1.00
30.75
6

ATOM
520
N
ARG
B
268
54.973
37.417
83.859
1.00
20.74
7

ATOM
521
CA
ARG
B
268
54.300
37.353
85.113
1.00
21.74
6

ATOM
522
C
ARG
B
268
55.300
37.447
86.220
1.00
23.40
6

ATOM
523
O
ARG
B
268
55.081
38.106
87.245
1.00
24.31
8

ATOM
524
CB
ARG
B
268
53.535
36.063
85.299
1.00
21.08
6

ATOM
525
CG
ARG
B
268
53.105
35.395
84.017
1.00
22.29
6

ATOM
526
CD
ARG
B
268
52.081
34.355
84.395
1.00
25.37
6

ATOM
527
NE
ARG
B
268
50.994
34.346
83.457
1.00
26.23
7

ATOM
528
CZ
ARG
B
268
50.397
33.229
83.149
1.00
27.97
6

ATOM
529
NH1
ARG
B
268
50.775
32.098
83.737
1.00
25.98
7

ATOM
530
NH2
ARG
B
268
49.426
33.207
82.246
1.00
23.99
7

ATOM
531
N
ASP
B
269
56.425
36.765
86.003
1.00
25.00
7

ATOM
532
CA
ASP
B
269
57.494
36.673
86.993
1.00
28.24
6

ATOM
533
C
ASP
B
269
57.922
38.039
87.590
1.00
27.60
6

ATOM
534
O
ASP
B
269
57.868
38.206
88.812
1.00
26.41
8

ATOM
535
CB
ASP
B
269
58.618
35.819
86.438
1.00
31.92
6

ATOM
536
CG
ASP
B
269
58.386
34.349
86.748
1.00
34.91
6

ATOM
537
OD1
ASP
B
269
57.290
33.828
86.438
1.00
38.62
8

ATOM
538
OD2
ASP
B
269
59.307
33.714
87.290
1.00
38.97
8

ATOM
539
N
GLN
B
270
58.346
39.010
86.785
1.00
27.67
7

ATOM
540
CA
GLN
B
270
58.742
40.314
87.336
1.00
26.52
6

ATOM
541
C
GLN
B
270
57.555
41.086
87.963
1.00
24.96
6

ATOM
542
O
GLN
B
270
57.655
41.578
89.089
1.00
23.72
8

ATOM
543
CB
GLN
B
270
59.449
41.190
86.246
1.00
31.64
6

ATOM
544
CG
GLN
B
270
60.815
41.761
86.654
1.00
39.68
6

ATOM
545
CD
GLN
B
270
61.347
42.954
85.831
1.00
44.31
6

ATOM
546
OE1
GLN
B
270
61.003
43.145
84.660
1.00
45.91
8

ATOM
547
NE2
GLN
B
270
62.211
43.876
86.256
1.00
45.94
7

ATOM
548
N
TYR
B
271
56.465
41.182
87.225
1.00
21.40
7

ATOM
549
CA
TYR
B
271
55.347
41.931
87.757
1.00
17.72
6

ATOM
550
C
TYR
B
271
54.986
41.351
89.098
1.00
16.86
6

ATOM
551
O
TYR
B
271
54.292
41.965
89.917
1.00
16.16
8

ATOM
552
CB
TYR
B
271
54.172
41.995
86.727
1.00
13.67
6

ATOM
553
CG
TYR
B
271
53.196
40.835
86.401
1.00
13.98
6

ATOM
554
CD1
TYR
B
271
52.302
40.312
87.337
1.00
17.13
6

ATOM
555
CD2
TYR
B
271
53.180
40.306
85.110
1.00
13.22
6

ATOM
556
CE1
TYR
B
271
51.420
39.294
86.993
1.00
16.95
6

ATOM
557
CE2
TYR
B
271
52.297
39.319
84.754
1.00
12.52
6

ATOM
558
CZ
TYR
B
271
51.421
38.821
85.701
1.00
14.39
6

ATOM
559
OH
TYR
B
271
50.537
37.830
85.356
1.00
16.88
8

ATOM
560
N
MET
B
272
55.457
40.159
89.336
1.00
15.53
7

ATOM
561
CA
MET
B
272
55.146
39.625
90.628
1.00
16.73
6

ATOM
562
C
MET
B
272
56.218
40.055
91.575
1.00
19.26
6

ATOM
563
O
MET
B
272
55.950
40.366
92.725
1.00
21.54
8

ATOM
564
CB
MET
B
272
55.037
38.105
90.604
1.00
17.85
6

ATOM
565
CG
MET
B
272
53.688
37.606
90.161
1.00
16.55
6

ATOM
566
SD
MET
B
272
53.775
35.984
89.392
1.00
14.21
16

ATOM
567
CE
MET
B
272
52.131
35.842
88.709
1.00
16.80
6

ATOM
568
N
ARG
B
273
57.436
40.089
91.072
1.00
21.00
7

ATOM
569
CA
ARG
B
273
58.417
40.492
92.006
1.00
21.44
6

ATOM
570
C
ARG
B
273
58.091
41.836
92.536
1.00
20.10
6

ATOM
571
O
ARG
B
273
57.993
42.042
93.741
1.00
19.92
8

ATOM
572
CB
ARG
B
273
59.813
40.482
91.416
1.00
23.58
6

ATOM
573
CG
ARG
B
273
60.475
39.145
91.650
1.00
28.23
6

ATOM
574
CD
ARG
B
273
61.924
39.165
91.272
1.00
31.68
6

ATOM
575
NE
ARG
B
273
62.116
39.066
89.831
1.00
33.66
7

ATOM
576
CZ
ARG
B
273
62.268
37.918
89.176
1.00
37.50
6

ATOM
577
NH1
ARG
B
273
62.217
36.764
89.832
1.00
37.42
7

ATOM
578
NH2
ARG
B
273
62.481
37.925
87.867
1.00
38.80
7

ATOM
579
N
THR
B
274
57.906
42.780
91.662
1.00
18.35
7

ATOM
580
CA
THR
B
274
57.749
44.117
92.113
1.00
20.36
6

ATOM
581
C
THR
B
274
56.394
44.512
92.708
1.00
18.73
6

ATOM
582
O
THR
B
274
56.323
45.441
93.518
1.00
19.21
8

ATOM
583
CB
THR
B
274
58.097
44.995
90.924
1.00
19.30
6

ATOM
584
OG1
THR
B
274
57.173
44.775
89.852
1.00
24.51
8

ATOM
585
CG2
THR
B
274
59.524
44.689
90.450
1.00
21.44
6

ATOM
586
N
GLY
B
275
55.330
43.823
92.330
1.00
16.89
7

ATOM
587
CA
GLY
B
275
53.993
44.150
92.803
1.00
14.72
6

ATOM
588
C
GLY
B
275
53.882
44.036
94.312
1.00
15.24
6

ATOM
589
O
GLY
B
275
54.337
43.066
94.918
1.00
16.13
8

ATOM
590
N
GLU
B
276
53.265
45.033
94.922
1.00
14.31
7

ATOM
591
CA
GLU
B
276
53.031
44.998
96.337
1.00
15.06
6

ATOM
592
C
GLU
B
276
51.622
44.500
96.558
1.00
16.32
6

ATOM
593
O
GLU
B
276
51.282
44.001
97.629
1.00
19.21
8

ATOM
594
CB
GLU
B
276
53.191
46.381
96.959
1.00
18.07
6

ATOM
595
CG
GLU
B
276
54.454
47.090
96.493
1.00
19.61
6

ATOM
596
CD
GLU
B
276
54.539
48.522
96.977
1.00
23.51
6

ATOM
597
OE1
GLU
B
276
53.493
49.158
97.215
1.00
25.72
8

ATOM
598
OE2
GLU
B
276
55.677
49.018
97.113
1.00
25.46
8

ATOM
599
N
GLY
B
277
50.787
44.655
95.529
1.00
16.19
7

ATOM
600
CA
GLY
B
277
49.381
44.251
95.623
1.00
13.63
6

ATOM
601
C
GLY
B
277
48.963
43.412
94.418
1.00
14.91
6

ATOM
602
O
GLY
B
277
49.495
43.577
93.334
1.00
14.02
8

ATOM
603
N
PHE
B
278
48.003
42.501
94.639
1.00
12.85
7

ATOM
604
CA
PHE
B
278
47.560
41.659
93.524
1.00
13.60
6

ATOM
605
C
PHE
B
278
46.102
41.389
93.558
1.00
12.89
6

ATOM
606
O
PHE
B
278
45.575
40.662
94.403
1.00
14.83
8

ATOM
607
CB
PHE
B
278
48.294
40.339
93.513
1.00
10.69
6

ATOM
608
CG
PHE
B
278
49.667
40.526
93.022
1.00
10.61
6

ATOM
609
CD1
PHE
B
278
50.715
39.894
93.658
1.00
11.20
6

ATOM
610
CD2
PHE
B
278
49.926
41.347
91.940
1.00
8.70
6

ATOM
611
CE1
PHE
B
278
52.000
40.086
93.254
1.00
10.58
6

ATOM
612
CE2
PHE
B
278
51.238
41.544
91.497
1.00
5.93
6

ATOM
613
CZ
PHE
B
278
52.276
40.914
92.169
1.00
7.62
6

ATOM
614
N
LEU
B
279
45.477
41.981
92.596
1.00
14.40
7

ATOM
615
CA
LEU
B
279
44.066
41.803
92.439
1.00
13.51
6

ATOM
616
C
LEU
B
279
43.810
40.540
91.679
1.00
12.64
6

ATOM
617
O
LEU
B
279
43.995
40.475
90.466
1.00
13.82
8

ATOM
618
CB
LEU
B
279
43.471
43.023
91.747
1.00
14.31
6

ATOM
619
CG
LEU
B
279
42.008
43.337
92.072
1.00
15.70
6

ATOM
620
CD1
LEU
B
279
41.870
43.732
93.536
1.00
16.34
6

ATOM
621
CD2
LEU
B
279
41.464
44.424
91.170
1.00
13.91
6

ATOM
622
N
CYS
B
280
43.376
39.513
92.389
1.00
11.95
7

ATOM
623
CA
CYS
B
280
43.085
38.230
91.729
1.00
9.99
6

ATOM
624
C
CYS
B
280
41.620
38.156
91.292
1.00
8.55
6

ATOM
625
O
CYS
B
280
40.735
37.826
92.094
1.00
10.52
8

ATOM
626
CB
CYS
B
280
43.482
37.053
92.640
1.00
11.29
6

ATOM
627
SG
CYS
B
280
45.205
37.119
93.235
1.00
15.57
16

ATOM
628
N
VAL
B
281
41.360
38.454
90.003
1.00
7.99
7

ATOM
629
CA
VAL
B
281
40.029
38.539
89.401
1.00
8.37
6

ATOM
630
C
VAL
B
281
39.594
37.286
88.649
1.00
9.01
6

ATOM
631
O
VAL
B
281
40.392
36.590
88.021
1.00
10.18
8

ATOM
632
CB
VAL
B
281
39.978
39.715
88.388
1.00
6.85
6

ATOM
633
CG1
VAL
B
281
38.566
39.928
87.891
1.00
7.84
6

ATOM
634
CG2
VAL
B
281
40.516
40.981
89.021
1.00
6.40
6

ATOM
635
N
PHE
B
282
38.301
37.029
88.743
1.00
10.93
7

ATOM
636
CA
PHE
B
282
37.672
35.924
88.028
1.00
11.84
6

ATOM
637
C
PHE
B
282
36.242
36.328
87.722
1.00
8.39
6

ATOM
638
O
PHE
B
282
35.701
37.253
88.329
1.00
8.10
8

ATOM
639
CB
PHE
B
282
37.698
34.617
88.843
1.00
13.30
6

ATOM
640
CG
PHE
B
282
36.692
34.527
89.967
1.00
15.63
6

ATOM
641
CD1
PHE
B
282
37.023
34.981
91.243
1.00
15.64
6

ATOM
642
CD2
PHE
B
282
35.420
33.998
89.753
1.00
12.04
6

ATOM
643
CE1
PHE
B
282
36.101
34.910
92.288
1.00
15.69
6

ATOM
644
CE2
PHE
B
282
34.493
33.925
90.789
1.00
14.14
6

ATOM
645
CZ
PHE
B
282
34.835
34.382
92.060
1.00
14.92
6

ATOM
646
N
ALA
B
283
35.663
35.637
86.790
1.00
6.99
7

ATOM
647
CA
ALA
B
283
34.291
35.923
86.409
1.00
8.48
6

ATOM
648
C
ALA
B
283
33.319
34.949
87.054
1.00
8.42
6

ATOM
649
O
ALA
B
283
33.575
33.743
87.089
1.00
5.63
8

ATOM
650
CB
ALA
B
283
34.157
35.879
84.892
1.00
3.99
6

ATOM
651
N
ILE
B
284
32.185
35.464
87.565
1.00
11.08
7

ATOM
652
CA
ILE
B
284
31.169
34.645
88.227
1.00
11.64
6

ATOM
653
C
ILE
B
284
30.447
33.819
87.164
1.00
13.24
6

ATOM
654
O
ILE
B
284
29.654
32.925
87.461
1.00
13.51
8

ATOM
655
CB
ILE
B
284
30.206
35.517
89.098
1.00
13.10
6

ATOM
656
CG1
ILE
B
284
29.599
36.660
88.265
1.00
13.98
6

ATOM
657
CG2
ILE
B
284
30.938
36.051
90.325
1.00
9.82
6

ATOM
658
CD1
ILE
B
284
28.344
36.266
87.520
1.00
13.48
6

ATOM
659
N
ASN
B
285
30.746
34.126
85.925
1.00
14.49
7

ATOM
660
CA
ASN
B
285
30.125
33.369
84.848
1.00
17.12
6

ATOM
661
C
ASN
B
285
31.130
32.434
84.141
1.00
17.14
6

ATOM
662
O
ASN
B
285
30.736
31.596
83.331
1.00
20.42
8

ATOM
663
CB
ASN
B
285
29.474
34.315
83.841
1.00
16.59
6

ATOM
664
CG
ASN
B
285
30.486
35.056
82.990
1.00
17.52
6

ATOM
665
OD1
ASN
B
285
31.636
35.215
83.377
1.00
16.16
8

ATOM
666
ND2
ASN
B
285
30.055
35.508
81.810
1.00
19.89
7

ATOM
667
N
ASN
B
286
32.433
32.548
84.440
1.00
16.60
7

ATOM
668
CA
ASN
B
286
33.480
31.722
83.846
1.00
15.02
6

ATOM
669
C
ASN
B
286
34.139
30.890
84.913
1.00
16.06
6

ATOM
670
O
ASN
B
286
35.030
31.376
85.611
1.00
15.12
8

ATOM
671
CB
ASN
B
286
34.515
32.628
83.168
1.00
16.22
6

ATOM
672
CG
ASN
B
286
35.717
31.920
82.569
1.00
18.01
6

ATOM
673
OD1
ASN
B
286
35.795
30.690
82.579
1.00
19.15
8

ATOM
674
ND2
ASN
B
286
36.644
32.705
82.027
1.00
19.29
7

ATOM
675
N
THR
B
287
33.710
29.649
85.078
1.00
15.22
7

ATOM
676
CA
THR
B
287
34.234
28.799
86.142
1.00
15.55
6

ATOM
677
C
THR
B
287
35.700
28.605
86.001
1.00
13.49
6

ATOM
678
O
THR
B
287
36.474
28.921
86.905
1.00
13.57
8

ATOM
679
CB
THR
B
287
33.592
27.457
86.097
1.00
16.78
6

ATOM
680
OG1
THR
B
287
32.194
27.607
86.323
1.00
19.11
8

ATOM
681
CG2
THR
B
287
34.198
26.555
87.149
1.00
20.00
6

ATOM
682
N
LYS
B
288
36.082
28.100
84.864
1.00
13.23
7

ATOM
683
CA
LYS
B
288
37.462
27.911
84.630
1.00
16.48
6

ATOM
684
C
LYS
B
288
38.287
29.007
85.279
1.00
15.41
6

ATOM
685
O
LYS
B
288
38.984
28.780
86.270
1.00
17.54
8

ATOM
686
CB
LYS
B
288
37.703
27.873
83.127
1.00
18.67
6

ATOM
687
CG
LYS
B
288
38.674
26.789
82.712
1.00
27.96
6

ATOM
688
CD
LYS
B
288
40.099
27.190
83.091
1.00
34.28
6

ATOM
689
CE
LYS
B
288
41.111
26.105
82.744
1.00
37.35
6

ATOM
690
NZ
LYS
B
288
41.045
24.955
83.691
1.00
38.62
7

ATOM
691
N
SER
B
289
38.186
30.203
84.685
1.00
14.60
7

ATOM
692
CA
SER
B
289
38.923
31.358
85.151
1.00
13.62
6

ATOM
693
C
SER
B
289
39.014
31.316
86.644
1.00
13.51
6

ATOM
694
O
SER
B
289
39.880
31.972
87.218
1.00
11.81
8

ATOM
695
CB
SER
B
289
38.283
32.658
84.679
1.00
7.70
6

ATOM
696
OG
SER
B
289
37.051
32.900
85.339
1.00
14.33
8

ATOM
697
N
PHE
B
290
38.162
30.566
87.272
1.00
16.19
7

ATOM
698
CA
PHE
B
290
38.177
30.511
88.710
1.00
20.54
6

ATOM
699
C
PHE
B
290
39.284
29.589
89.204
1.00
23.94
6

ATOM
700
O
PHE
B
290
40.243
29.997
89.871
1.00
26.17
8

ATOM
701
CB
PHE
B
290
36.823
30.097
89.202
1.00
21.91
6

ATOM
702
CG
PHE
B
290
36.894
29.870
90.660
1.00
23.19
6

ATOM
703
CD1
PHE
B
290
37.068
30.937
91.537
1.00
24.20
6

ATOM
704
CD2
PHE
B
290
36.778
28.585
91.156
1.00
24.48
6

ATOM
705
CE1
PHE
B
290
37.126
30.728
92.883
1.00
24.07
6

ATOM
706
CE2
PHE
B
290
36.836
28.366
92.530
1.00
23.65
6

ATOM
707
CZ
PHE
B
290
37.010
29.442
93.395
1.00
24.70
6

ATOM
708
N
GLU
B
291
39.103
28.325
88.837
1.00
25.09
7

ATOM
709
CA
GLU
B
291
40.049
27.295
89.187
1.00
25.94
6

ATOM
710
C
GLU
B
291
41.403
27.887
88.930
1.00
26.14
6

ATOM
711
O
GLU
B
291
42.392
27.567
89.603
1.00
28.61
8

ATOM
712
CB
GLU
B
291
39.885
26.018
88.346
1.00
26.99
6

ATOM
713
CG
GLU
B
291
38.516
25.391
88.483
1.00
32.52
6

ATOM
714
CD
GLU
B
291
38.256
24.273
87.488
1.00
38.36
6

ATOM
715
OE1
GLU
B
291
38.969
24.180
86.472
1.00
39.10
8

ATOM
716
OE2
GLU
B
291
37.323
23.488
87.727
1.00
39.23
8

ATOM
717
N
ASP
B
292
41.410
28.760
87.944
1.00
24.07
7

ATOM
718
CA
ASP
B
292
42.632
29.400
87.560
1.00
22.65
6

ATOM
719
C
ASP
B
292
43.135
30.300
88.692
1.00
21.52
6

ATOM
720
O
ASP
B
292
44.342
30.320
88.962
1.00
18.98
8

ATOM
721
CB
ASP
B
292
42.426
30.211
86.294
1.00
22.60
6

ATOM
722
CG
ASP
B
292
42.621
29.373
85.047
1.00
24.88
6

ATOM
723
OD1
ASP
B
292
43.200
28.275
85.154
1.00
26.11
8

ATOM
724
OD2
ASP
B
292
42.186
29.811
83.948
1.00
27.57
8

ATOM
725
N
ILE
B
293
42.229
31.033
89.335
1.00
21.66
7

ATOM
726
CA
ILE
B
293
42.642
31.926
90.389
1.00
22.90
6

ATOM
727
C
ILE
B
293
43.410
31.156
91.471
1.00
20.93
6

ATOM
728
O
ILE
B
293
43.951
31.773
92.377
1.00
20.20
8

ATOM
729
CB
ILE
B
293
41.408
32.672
90.961
1.00
23.92
6

ATOM
730
CG1
ILE
B
293
41.774
34.116
91.301
1.00
27.22
6

ATOM
731
CG2
ILE
B
293
40.861
31.969
92.197
1.00
26.92
6

ATOM
732
CD1
ILE
B
293
42.411
34.865
90.159
1.00
26.07
6

ATOM
733
N
HIS
B
294
43.471
29.817
91.406
1.00
20.43
7

ATOM
734
CA
HIS
B
294
44.207
29.015
92.411
1.00
21.44
6

ATOM
735
C
HIS
B
294
45.662
29.135
92.133
1.00
20.03
6

ATOM
736
O
HIS
B
294
46.498
29.405
92.983
1.00
18.65
8

ATOM
737
CB
HIS
B
294
43.919
27.525
92.255
1.00
25.77
6

ATOM
738
CG
HIS
B
294
42.434
27.217
92.436
1.00
29.47
6

ATOM
739
ND1
HIS
B
294
41.428
28.071
92.036
1.00
30.04
7

ATOM
740
CD2
HIS
B
294
41.816
26.160
93.019
1.00
31.40
6

ATOM
741
CE1
HIS
B
294
40.256
27.552
92.359
1.00
31.12
6

ATOM
742
NE2
HIS
B
294
40.463
26.394
92.957
1.00
31.99
7

ATOM
743
N
GLN
B
295
45.902
28.933
90.862
1.00
18.43
7

ATOM
744
CA
GLN
B
295
47.214
28.978
90.254
1.00
19.41
6

ATOM
745
C
GLN
B
295
47.914
30.340
90.463
1.00
17.28
6

ATOM
746
O
GLN
B
295
49.045
30.393
90.955
1.00
16.23
8

ATOM
747
CB
GLN
B
295
47.111
28.630
88.796
1.00
23.63
6

ATOM
748
CG
GLN
B
295
46.125
27.494
88.552
1.00
29.09
6

ATOM
749
CD
GLN
B
295
46.595
26.180
89.133
1.00
33.99
6

ATOM
750
OE1
GLN
B
295
46.102
25.726
90.162
1.00
40.04
8

ATOM
751
NE2
GLN
B
295
47.546
25.396
88.625
1.00
36.69
7

ATOM
752
N
TYR
B
296
47.257
31.423
90.115
1.00
14.91
7

ATOM
753
CA
TYR
B
296
47.837
32.713
90.299
1.00
14.09
6

ATOM
754
C
TYR
B
296
48.242
32.938
91.800
1.00
15.50
6

ATOM
755
O
TYR
B
296
49.353
33.410
92.086
1.00
16.74
8

ATOM
756
CB
TYR
B
296
46.878
33.752
89.640
1.00
11.04
6

ATOM
757
CG
TYR
B
296
46.899
33.720
88.101
1.00
13.49
6

ATOM
758
CD1
TYR
B
296
47.907
34.404
87.419
1.00
13.01
6

ATOM
759
CD2
TYR
B
296
45.948
33.031
87.352
1.00
14.29
6

ATOM
760
CE1
TYR
B
296
47.972
34.398
86.036
1.00
13.01
6

ATOM
761
CE2
TYR
B
296
46.006
33.016
85.958
1.00
14.55
6

ATOM
762
CZ
TYR
B
296
47.025
33.703
85.310
1.00
16.45
6

ATOM
763
OH
TYR
B
296
47.079
33.690
83.938
1.00
21.81
8

ATOM
764
N
ARG
B
297
47.349
32.609
92.759
1.00
16.79
7

ATOM
765
CA
ARG
B
297
47.642
32.792
94.215
1.00
19.11
6

ATOM
766
C
ARG
B
297
48.909
32.041
94.611
1.00
19.28
6

ATOM
767
O
ARG
B
297
49.685
32.523
95.446
1.00
16.61
8

ATOM
768
CB
ARG
B
297
46.457
32.315
95.110
1.00
24.36
6

ATOM
769
CG
ARG
B
297
46.243
33.059
96.427
1.00
28.41
6

ATOM
770
CD
ARG
B
297
47.235
32.656
97.517
1.00
34.72
6

ATOM
771
NE
ARG
B
297
46.599
32.095
98.726
1.00
40.89
7

ATOM
772
CZ
ARG
B
297
47.022
32.275
99.977
1.00
42.53
6

ATOM
773
NH1
ARG
B
297
48.101
33.013
100.219
1.00
42.99
7

ATOM
774
NH2
ARG
B
297
46.365
31.716
100.992
1.00
42.30
7

ATOM
775
N
GLU
B
298
49.107
30.856
94.022
1.00
18.62
7

ATOM
776
CA
GLU
B
298
50.266
30.062
94.385
1.00
20.41
6

ATOM
777
C
GLU
B
298
51.598
30.467
93.680
1.00
19.65
6

ATOM
778
O
GLU
B
298
52.657
30.256
94.275
1.00
20.78
8

ATOM
779
CB
GLU
B
298
49.962
28.577
94.191
1.00
23.16
6

ATOM
780
CG
GLU
B
298
49.546
28.127
92.795
1.00
30.82
6

ATOM
781
CD
GLU
B
298
49.230
26.641
92.685
1.00
36.03
6

ATOM
782
OE1
GLU
B
298
48.642
26.091
93.647
1.00
42.37
8

ATOM
783
OE2
GLU
B
298
49.575
26.018
91.649
1.00
35.30
8

ATOM
784
N
GLN
B
299
51.592
31.044
92.452
1.00
18.00
7

ATOM
785
CA
GLN
B
299
52.852
31.493
91.796
1.00
19.09
6

ATOM
786
C
GLN
B
299
53.218
32.885
92.247
1.00
19.41
6

ATOM
787
O
GLN
B
299
54.136
33.519
91.723
1.00
19.62
8

ATOM
788
CB
GLN
B
299
52.801
31.523
90.253
1.00
21.04
6

ATOM
789
CG
GLN
B
299
54.101
32.054
89.597
1.00
23.94
6

ATOM
790
CD
GLN
B
299
54.005
32.413
88.105
1.00
28.64
6

ATOM
791
OE1
GLN
B
299
54.973
32.854
87.490
1.00
30.41
8

ATOM
792
NE2
GLN
B
299
52.930
32.282
87.347
1.00
26.45
7

ATOM
793
N
ILE
B
300
52.469
33.339
93.214
1.00
18.61
7

ATOM
794
CA
ILE
B
300
52.773
34.624
93.761
1.00
18.21
6

ATOM
795
C
ILE
B
300
53.516
34.375
95.018
1.00
18.07
6

ATOM
796
O
ILE
B
300
54.332
35.178
95.456
1.00
17.22
8

ATOM
797
CB
ILE
B
300
51.512
35.424
94.066
1.00
15.78
6

ATOM
798
CG1
ILE
B
300
50.878
35.876
92.757
1.00
15.72
6

ATOM
799
CG2
ILE
B
300
51.829
36.621
94.943
1.00
14.51
6

ATOM
800
CD1
ILE
B
300
49.631
36.707
92.939
1.00
12.62
6

ATOM
801
N
LYS
B
301
53.239
33.258
95.604
1.00
20.69
7

ATOM
802
CA
LYS
B
301
53.943
32.952
96.812
1.00
23.14
6

ATOM
803
C
LYS
B
301
55.394
32.744
96.457
1.00
23.52
6

ATOM
804
O
LYS
B
301
56.278
33.488
96.899
1.00
24.82
8

ATOM
805
CB
LYS
B
301
53.353
31.741
97.509
1.00
25.27
6

ATOM
806
CG
LYS
B
301
51.854
31.833
97.582
1.00
29.79
6

ATOM
807
CD
LYS
B
301
51.260
30.734
98.440
1.00
32.39
6

ATOM
808
CE
LYS
B
301
51.661
29.353
97.936
1.00
33.03
6

ATOM
809
NZ
LYS
B
301
51.328
28.281
98.914
1.00
33.49
7

ATOM
810
N
ARG
B
302
55.601
31.714
95.657
1.00
24.99
7

ATOM
811
CA
ARG
B
302
56.895
31.287
95.118
1.00
29.10
6

ATOM
812
C
ARG
B
302
57.887
32.412
95.082
1.00
28.73
6

ATOM
813
O
ARG
B
302
58.783
32.526
95.912
1.00
31.22
8

ATOM
814
CB
ARG
B
302
56.690
30.708
93.713
1.00
32.23
6

ATOM
815
CG
ARG
B
302
57.953
30.188
93.043
1.00
39.66
6

ATOM
816
CD
ARG
B
302
57.656
29.640
91.647
1.00
46.37
6

ATOM
817
NE
ARG
B
302
56.709
28.527
91.698
1.00
52.02
7

ATOM
818
CZ
ARG
B
302
55.781
28.283
90.772
1.00
54.94
6

ATOM
819
NH1
ARG
B
302
55.661
29.075
89.712
1.00
54.32
7

ATOM
820
NH2
ARG
B
302
54.979
27.233
90.899
1.00
55.66
7

ATOM
821
N
VAL
B
303
57.695
33.212
94.056
1.00
27.82
7

ATOM
822
CA
VAL
B
303
58.504
34.390
93.779
1.00
26.23
6

ATOM
823
C
VAL
B
303
58.691
35.210
95.034
1.00
25.98
6

ATOM
824
O
VAL
B
303
59.755
35.241
95.642
1.00
28.38
8

ATOM
825
CB
VAL
B
303
57.882
35.214
92.677
1.00
23.16
6

ATOM
826
CG1
VAL
B
303
58.763
36.384
92.307
1.00
23.59
6

ATOM
827
CG2
VAL
B
303
57.628
34.338
91.455
1.00
24.44
6

ATOM
828
N
LYS
B
304
57.623
35.867
95.408
1.00
25.53
7

ATOM
829
CA
LYS
B
304
57.670
36.645
96.577
1.00
25.49
6

ATOM
830
C
LYS
B
304
58.117
35.791
97.760
1.00
26.69
6

ATOM
831
O
LYS
B
304
58.681
36.316
98.724
1.00
29.45
8

ATOM
832
CB
LYS
B
304
56.322
37.296
96.834
1.00
23.46
6

ATOM
833
CG
LYS
B
304
55.772
38.098
95.654
1.00
22.09
6

ATOM
834
CD
LYS
B
304
54.750
39.111
96.115
1.00
22.17
6

ATOM
835
CE
LYS
B
304
55.412
40.358
96.674
1.00
18.46
6

ATOM
836
NZ
LYS
B
304
56.105
41.146
95.615
1.00
15.26
7

ATOM
837
N
ASP
B
305
57.893
34.477
97.719
1.00
25.00
7

ATOM
838
CA
ASP
B
305
58.265
33.681
98.861
1.00
24.80
6

ATOM
839
C
ASP
B
305
57.669
34.284
100.110
1.00
24.89
6

ATOM
840
O
ASP
B
305
58.357
34.845
100.979
1.00
20.71
8

ATOM
841
CB
ASP
B
305
59.790
33.568
98.973
1.00
28.25
6

ATOM
842
CG
ASP
B
305
60.239
32.534
99.982
1.00
33.23
6

ATOM
843
OD1
ASP
B
305
59.562
31.496
100.102
1.00
33.95
8

ATOM
844
OD2
ASP
B
305
61.285
32.754
100.652
1.00
34.62
8

ATOM
845
N
SER
B
306
56.341
34.151
100.165
1.00
25.98
7

ATOM
846
CA
SER
B
306
55.493
34.689
101.223
1.00
30.29
6

ATOM
847
C
SER
B
306
54.074
34.093
101.324
1.00
33.52
6

ATOM
848
O
SER
B
306
53.396
33.922
100.308
1.00
33.04
8

ATOM
849
CB
SER
B
306
55.393
36.213
101.046
1.00
30.37
6

ATOM
850
OG
SER
B
306
54.882
36.833
102.214
1.00
31.79
8

ATOM
851
N
ASP
B
307
53.659
33.761
102.569
1.00
36.46
7

ATOM
852
CA
ASP
B
307
52.329
33.236
102.930
1.00
38.66
6

ATOM
853
C
ASP
B
307
51.451
34.459
103.301
1.00
37.84
6

ATOM
854
O
ASP
B
307
50.268
34.334
103.583
1.00
38.03
8

ATOM
855
CB
ASP
B
307
52.401
32.228
104.103
1.00
43.58
6

ATOM
856
CG
ASP
B
307
53.136
30.936
103.745
1.00
48.79
6

ATOM
857
OD1
ASP
B
307
52.598
30.161
102.924
1.00
50.11
8

ATOM
858
OD2
ASP
B
307
54.226
30.696
104.292
1.00
51.33
8

ATOM
859
N
ASP
B
308
52.083
35.644
103.305
1.00
36.46
7

ATOM
860
CA
ASP
B
308
51.395
36.928
103.576
1.00
36.34
6

ATOM
861
C
ASP
B
308
51.653
37.997
102.534
1.00
30.99
6

ATOM
862
O
ASP
B
308
52.464
38.897
102.711
1.00
29.55
8

ATOM
863
CB
ASP
B
308
51.730
37.467
104.972
1.00
40.75
6

ATOM
864
CG
ASP
B
308
50.575
38.336
105.494
1.00
45.02
6

ATOM
865
OD1
ASP
B
308
50.552
39.542
105.170
1.00
48.17
8

ATOM
866
OD2
ASP
B
308
49.717
37.816
106.221
1.00
45.72
8

ATOM
867
N
VAL
B
309
50.921
37.874
101.447
1.00
27.11
7

ATOM
868
CA
VAL
B
309
51.040
38.828
100.376
1.00
21.48
6

ATOM
869
C
VAL
B
309
49.741
39.577
100.251
1.00
18.32
6

ATOM
870
O
VAL
B
309
48.645
39.034
100.447
1.00
17.92
8

ATOM
871
CB
VAL
B
309
51.321
38.118
99.025
1.00
21.27
6

ATOM
872
CG1
VAL
B
309
51.520
39.145
97.914
1.00
18.26
6

ATOM
873
CG2
VAL
B
309
52.529
37.195
99.138
1.00
19.59
6

ATOM
874
N
PRO
B
310
49.879
40.860
99.921
1.00
16.40
7

ATOM
875
CA
PRO
B
310
48.670
41.712
99.670
1.00
16.13
6

ATOM
876
C
PRO
B
310
47.745
41.187
98.570
1.00
15.20
6

ATOM
877
O
PRO
B
310
48.088
41.253
97.388
1.00
14.88
8

ATOM
878
CB
PRO
B
310
49.279
43.078
99.484
1.00
16.76
6

ATOM
879
CG
PRO
B
310
50.396
43.055
100.489
1.00
16.46
6

ATOM
880
CD
PRO
B
310
50.793
41.637
100.764
1.00
17.57
6

ATOM
881
N
MET
B
311
46.610
40.687
98.963
1.00
15.46
7

ATOM
882
CA
MET
B
311
45.743
40.158
97.980
1.00
17.63
6

ATOM
883
C
MET
B
311
44.322
40.402
98.272
1.00
16.15
6

ATOM
684
O
MET
B
311
43.947
40.926
99.323
1.00
17.35
8

ATOM
885
CB
MET
B
311
45.962
38.660
97.849
1.00
16.52
6

ATOM
886
CG
MET
B
311
46.959
38.273
96.790
1.00
21.56
6

ATOM
887
SD
MET
B
311
47.610
36.613
97.073
1.00
22.66
16

ATOM
888
CE
MET
B
311
48.602
36.392
95.605
1.00
23.62
6

ATOM
889
N
VAL
B
312
43.536
40.016
97.338
1.00
16.14
7

ATOM
890
CA
VAL
B
312
42.158
40.232
97.457
1.00
14.33
6

ATOM
891
C
VAL
B
312
41.548
39.408
96.357
1.00
15.23
6

ATOM
892
O
VAL
B
312
42.098
39.330
95.267
1.00
15.07
8

ATOM
893
CB
VAL
B
312
41.803
41.728
97.284
1.00
12.34
6

ATOM
894
CG1
VAL
B
312
40.281
41.915
97.241
1.00
10.09
6

ATOM
895
CG2
VAL
B
312
42.418
42.564
98.408
1.00
12.76
6

ATOM
896
N
LEU
B
313
40.413
38.765
96.632
1.00
14.69
7

ATOM
897
CA
LEU
B
313
39.708
37.920
95.621
1.00
14.64
6

ATOM
898
C
LEU
B
313
38.525
38.697
95.032
1.00
14.42
6

ATOM
899
O
LEU
B
313
37.662
39.146
95.783
1.00
14.55
8

ATOM
900
CB
LEU
B
313
39.245
36.615
96.275
1.00
13.14
6

ATOM
901
CG
LEU
B
313
38.647
35.566
95.352
1.00
14.44
6

ATOM
902
CD1
LEU
B
313
39.699
34.972
94.432
1.00
14.50
6

ATOM
903
CD2
LEU
B
313
37.976
34.475
96.164
1.00
15.81
6

ATOM
904
N
VAL
B
314
38.500
38.864
93.713
1.00
14.99
7

ATOM
905
CA
VAL
B
314
37.432
39.607
93.055
1.00
11.91
6

ATOM
906
C
VAL
B
314
36.583
38.766
92.110
1.00
10.69
6

ATOM
907
O
VAL
B
314
37.101
38.113
91.211
1.00
11.82
8

ATOM
908
CB
VAL
B
314
38.000
40.825
92.281
1.00
11.45
6

ATOM
909
CG1
VAL
B
314
36.900
41.536
91.518
1.00
12.32
6

ATOM
910
CG2
VAL
B
314
38.674
41.788
93.251
1.00
11.49
6

ATOM
911
N
GLY
B
315
35.273
38.788
92.346
1.00
11.35
7

ATOM
912
CA
GLY
B
315
34.330
38.077
91.504
1.00
9.22
6

ATOM
913
C
GLY
B
315
33.689
39.127
90.615
1.00
12.51
6

ATOM
914
O
GLY
B
315
32.731
39.799
91.017
1.00
12.53
8

ATOM
915
N
ASN
B
316
34.237
39.287
89.414
1.00
10.62
7

ATOM
916
CA
ASN
B
316
33.748
40.285
88.469
1.00
10.66
6

ATOM
917
C
ASN
B
316
32.563
39.799
87.642
1.00
11.60
6

ATOM
918
O
ASN
B
316
32.296
38.595
87.566
1.00
11.45
8

ATOM
919
CB
ASN
B
316
34.893
40.744
87.549
1.00
6.83
6

ATOM
920
CG
ASN
B
316
34.547
41.995
86.760
1.00
7.52
6

ATOM
921
OD1
ASN
B
316
34.029
42.962
87.310
1.00
9.62
8

ATOM
922
ND2
ASN
B
316
34.834
41.980
85.462
1.00
6.51
7

ATOM
923
N
LYS
B
317
31.888
40.755
87.003
1.00
11.29
7

ATOM
924
CA
LYS
B
317
30.721
40.505
86.159
1.00
11.62
6

ATOM
925
C
LYS
B
317
29.506
40.053
86.974
1.00
14.05
6

ATOM
926
O
LYS
B
317
28.733
39.201
86.530
1.00
14.80
8

ATOM
927
CB
LYS
B
317
31.049
39.478
85.065
1.00
11.25
6

ATOM
928
CG
LYS
B
317
32.190
39.886
84.146
1.00
15.13
6

ATOM
929
CD
LYS
B
317
32.355
38.911
83.000
1.00
15.16
6

ATOM
930
CE
LYS
B
317
33.537
39.291
82.121
1.00
15.28
6

ATOM
931
NZ
LYS
B
317
33.660
38.392
80.939
1.00
11.37
7

ATOM
932
N
CYS
B
318
29.325
40.633
88.163
1.00
14.30
7

ATOM
933
CA
CYS
B
318
28.211
40.281
89.032
1.00
15.00
6

ATOM
934
C
CYS
B
318
26.903
40.873
88.524
1.00
14.73
6

ATOM
935
O
CYS
B
318
25.837
40.685
89.137
1.00
15.53
8

ATOM
936
CB
CYS
B
318
28.482
40.747
90.463
1.00
14.78
6

ATOM
937
SG
CYS
B
318
29.868
39.913
91.271
1.00
21.51
16

ATOM
938
N
ASP
B
319
26.950
41.595
87.413
1.00
15.68
7

ATOM
939
CA
ASP
B
319
25.767
42.195
86.805
1.00
17.22
6

ATOM
940
C
ASP
B
319
25.043
41.167
85.929
1.00
19.24
6

ATOM
941
O
ASP
B
319
23.852
41.307
85.645
1.00
20.82
8

ATOM
942
CB
ASP
B
319
26.169
43.404
85.957
1.00
17.35
6

ATOM
943
CG
ASP
B
319
27.175
43.049
84.883
1.00
16.69
6

ATOM
944
OD1
ASP
B
319
28.385
43.018
85.187
1.00
14.67
8

ATOM
945
OD2
ASP
B
319
26.755
42.783
83.741
1.00
13.22
8

ATOM
946
N
LEU
B
320
25.777
40.146
85.495
1.00
20.76
7

ATOM
947
CA
LEU
B
320
25.232
39.086
84.652
1.00
20.59
6

ATOM
948
C
LEU
B
320
24.428
38.086
85.473
1.00
22.70
6

ATOM
949
O
LEU
B
320
24.870
37.639
86.531
1.00
22.34
8

ATOM
950
CB
LEU
B
320
26.359
38.367
83.910
1.00
20.19
6

ATOM
951
CG
LEU
B
320
27.196
39.216
82.947
1.00
22.49
6

ATOM
952
CD1
LEU
B
320
28.331
38.387
82.364
1.00
22.21
6

ATOM
953
CD2
LEU
B
320
26.320
39.773
81.834
1.00
20.51
6

ATOM
954
N
ALA
B
321
23.250
37.698
84.969
1.00
24.37
7

ATOM
955
CA
ALA
B
321
22.362
36.760
85.648
1.00
25.35
6

ATOM
956
C
ALA
B
321
22.850
35.303
85.543
1.00
25.06
6

ATOM
957
O
ALA
B
321
22.642
34.523
86.488
1.00
24.31
8

ATOM
958
CB
ALA
B
321
20.946
36.894
85.095
1.00
25.21
6

ATOM
959
N
ALA
B
322
23.499
34.891
84.442
1.00
27.03
7

ATOM
960
CA
ALA
B
322
24.041
33.524
84.351
1.00
27.13
6

ATOM
961
C
ALA
B
322
25.325
33.427
85.159
1.00
28.15
6

ATOM
962
O
ALA
B
322
26.342
34.022
84.804
1.00
28.32
8

ATOM
963
CB
ALA
B
322
24.303
33.130
82.909
1.00
28.01
6

ATOM
964
N
ARG
B
323
25.319
32.665
86.266
1.00
27.87
7

ATOM
965
CA
ARG
B
323
26.502
32.518
87.133
1.00
27.49
6

ATOM
966
C
ARG
B
323
26.871
31.058
87.236
1.00
28.01
6

ATOM
967
O
ARG
B
323
26.003
30.217
87.425
1.00
29.35
8

ATOM
968
CB
ARG
B
323
26.223
33.096
88.529
1.00
25.77
6

ATOM
969
CG
ARG
B
323
27.067
32.531
89.661
1.00
28.26
6

ATOM
970
CD
ARG
B
323
26.557
32.982
91.025
1.00
28.88
6

ATOM
971
NE
ARG
B
323
26.522
34.436
91.170
1.00
29.61
7

ATOM
972
CZ
ARG
B
323
27.514
35.138
91.712
1.00
29.96
6

ATOM
973
NH1
ARG
B
323
28.601
34.527
92.161
1.00
30.42
7

ATOM
974
NH2
ARG
B
323
27.411
36.455
91.792
1.00
28.26
7

ATOM
975
N
THR
B
324
28.125
30.789
87.106
1.00
27.10
7

ATOM
976
CA
THR
B
324
28.524
29.419
87.261
1.00
28.12
6

ATOM
977
C
THR
B
324
29.352
29.364
88.554
1.00
29.04
6

ATOM
978
O
THR
B
324
29.711
26.281
89.010
1.00
28.56
8

ATOM
979
CB
THR
B
324
29.285
28.956
86.017
1.00
26.48
6

ATOM
980
OG1
THR
B
324
30.547
29.643
85.959
1.00
25.89
8

ATOM
981
CG2
THR
B
324
28.479
29.248
84.755
1.00
26.61
6

ATOM
982
N
VAL
B
325
29.652
30.532
89.129
1.00
30.37
7

ATOM
983
CA
VAL
B
325
30.459
30.565
90.360
1.00
31.86
6

ATOM
984
C
VAL
B
325
29.808
31.333
91.489
1.00
34.18
6

ATOM
985
O
VAL
B
325
29.773
32.556
91.589
1.00
34.29
8

ATOM
986
CB
VAL
B
325
31.854
31.123
90.118
1.00
30.27
6

ATOM
987
CG1
VAL
B
325
32.680
31.031
91.398
1.00
28.13
6

ATOM
988
CG2
VAL
B
325
32.536
30.403
88.973
1.00
27.79
6

ATOM
989
N
GLU
B
326
29.296
30.457
92.313
1.00
36.05
7

ATOM
990
CA
GLU
B
326
28.547
30.657
93.527
1.00
37.94
6

ATOM
991
C
GLU
B
326
29.434
31.050
94.689
1.00
36.63
6

ATOM
992
O
GLU
B
326
30.157
30.274
95.307
1.00
34.91
8

ATOM
993
CB
GLU
B
326
27.859
29.359
93.873
1.00
40.60
6

ATOM
994
CG
GLU
B
326
28.863
28.220
93.698
1.00
43.96
6

ATOM
995
CD
GLU
B
326
28.222
26.856
93.537
1.00
46.02
6

ATOM
996
OE1
GLU
B
326
27.162
26.618
94.170
1.00
44.64
8

ATOM
997
OE2
GLU
B
326
28.767
26.011
92.800
1.00
47.53
8

ATOM
998
N
SER
B
327
29.301
32.315
94.927
1.00
35.64
7

ATOM
999
CA
SER
B
327
29.983
33.071
95.948
1.00
36.21
6

ATOM
1000
C
SER
B
327
30.604
32.249
97.116
1.00
36.71
6

ATOM
1001
O
SER
B
327
31.810
32.343
97.325
1.00
37.79
8

ATOM
1002
CB
SER
B
327
29.023
34.143
96.444
1.00
34.47
6

ATOM
1003
OG
SER
B
327
28.347
34.768
95.363
1.00
36.70
8

ATOM
1004
N
ARG
B
328
29.834
31.449
97.864
1.00
36.85
7

ATOM
1005
CA
ARG
B
328
30.323
30.666
99.009
1.00
37.15
6

ATOM
1006
C
ARG
B
328
31.701
29.991
98.770
1.00
35.23
6

ATOM
1007
O
ARG
B
328
32.637
30.199
99.540
1.00
33.28
8

ATOM
1008
CB
ARG
B
328
29.278
29.624
99.368
1.00
40.41
6

ATOM
1009
CG
ARG
B
328
29.594
28.789
100.601
1.00
47.12
6

ATOM
1010
CD
ARG
B
328
29.943
29.654
101.803
1.00
54.33
6

ATOM
1011
NE
ARG
B
328
28.927
30.666
102.091
1.00
58.74
7

ATOM
1012
CZ
ARG
B
328
29.126
31.666
102.948
1.00
60.74
6

ATOM
1013
NH1
ARG
B
328
30.274
31.763
103.609
1.00
60.97
7

ATOM
1014
NH2
ARG
B
328
28.185
32.584
103.128
1.00
61.45
7

ATOM
1015
N
GLN
B
329
31.796
29.191
97.701
1.00
33.86
7

ATOM
1016
CA
GLN
B
329
33.049
28.485
97.360
1.00
30.87
6

ATOM
1017
C
GLN
B
329
34.146
29.497
97.094
1.00
30.48
6

ATOM
1018
O
GLN
B
329
35.317
29.148
97.130
1.00
31.09
8

ATOM
1019
CB
GLN
B
329
32.820
27.483
96.203
1.00
31.54
6

ATOM
1020
CG
GLN
B
329
32.863
28.079
94.779
1.00
33.41
6

ATOM
1021
CD
GLN
B
329
32.556
27.067
93.675
1.00
35.16
6

ATOM
1022
OE1
GLN
B
329
33.358
26.175
93.400
1.00
35.03
8

ATOM
1023
NE2
GLN
B
329
31.450
27.012
92.939
1.00
32.98
7

ATOM
1024
N
ALA
B
330
33.777
30.728
96.841
1.00
29.35
7

ATOM
1025
CA
ALA
B
330
34.778
31.748
96.675
1.00
29.00
6

ATOM
1026
C
ALA
B
330
34.958
32.411
98.035
1.00
28.83
6

ATOM
1027
O
ALA
B
330
36.061
32.726
98.470
1.00
26.52
8

ATOM
1028
CB
ALA
B
330
34.360
32.778
95.638
1.00
25.88
6

ATOM
1029
N
GLN
B
331
33.839
32.590
98.688
1.00
29.03
7

ATOM
1030
CA
GLN
B
331
33.963
33.150
99.982
1.00
30.45
6

ATOM
1031
C
GLN
B
331
34.838
32.206
100.813
1.00
29.26
6

ATOM
1032
O
GLN
B
331
35.760
32.636
101.513
1.00
29.19
8

ATOM
1033
CB
GLN
B
331
32.583
33.373
100.609
1.00
32.66
6

ATOM
1034
CG
GLN
B
331
31.710
34.274
99.763
1.00
39.01
6

ATOM
1035
CD
GLN
B
331
30.500
34.733
100.496
1.00
42.03
6

ATOM
1036
OE1
GLN
B
331
30.155
34.184
101.535
1.00
42.26
8

ATOM
1037
NE2
GLN
B
331
29.683
35.716
100.136
1.00
42.84
7

ATOM
1038
N
ASP
B
332
34.578
30.899
100.741
1.00
28.82
7

ATOM
1039
CA
ASP
B
332
35.325
29.900
101.503
1.00
29.36
6

ATOM
1040
C
ASP
B
332
36.776
29.759
101.050
1.00
28.87
6

ATOM
1041
O
ASP
B
332
37.565
29.154
101.760
1.00
31.96
8

ATOM
1042
CB
ASP
B
332
34.641
28.525
101.401
1.00
30.32
6

ATOM
1043
CG
ASP
B
332
33.176
28.561
101.779
1.00
34.65
6

ATOM
1044
OD1
ASP
B
332
32.752
29.525
102.445
1.00
38.52
8

ATOM
1045
OD2
ASP
B
332
32.431
27.623
101.399
1.00
35.26
8

ATOM
1046
N
LEU
B
333
37.142
30.285
99.873
1.00
28.35
7

ATOM
1047
CA
LEU
B
333
38.538
30.120
99.432
1.00
26.00
6

ATOM
1048
C
LEU
B
333
39.447
31.151
100.026
1.00
24.97
6

ATOM
1049
O
LEU
B
333
40.598
30.892
100.384
1.00
24.07
8

ATOM
1050
CB
LEU
B
333
38.623
30.217
97.932
1.00
24.43
6

ATOM
1051
CG
LEU
B
333
40.043
30.371
97.417
1.00
23.13
6

ATOM
1052
CD1
LEU
B
333
40.793
29.047
97.511
1.00
22.58
6

ATOM
1053
CD2
LEU
B
333
40.026
30.877
95.979
1.00
21.94
6

ATOM
1054
N
ALA
B
334
38.906
32.361
100.143
1.00
23.89
7

ATOM
1055
CA
ALA
B
334
39.631
33.451
100.749
1.00
24.51
6

ATOM
1056
C
ALA
B
334
39.704
33.242
102.240
1.00
25.10
6

ATOM
1057
O
ALA
B
334
40.111
34.113
103.009
1.00
24.28
8

ATOM
1058
CB
ALA
B
334
38.979
34.800
100.432
1.00
25.48
6

ATOM
1059
N
ARG
B
335
39.283
32.069
102.639
1.00
25.04
7

ATOM
1060
CA
ARG
B
335
39.290
31.822
104.043
1.00
27.24
6

ATOM
1061
C
ARG
B
335
40.443
30.945
104.429
1.00
25.86
6

ATOM
1062
O
ARG
B
335
40.782
30.805
105.619
1.00
27.08
8

ATOM
1063
CB
ARG
B
335
37.954
31.252
104.459
1.00
30.11
6

ATOM
1064
CG
ARG
B
335
37.625
31.552
105.898
1.00
36.34
6

ATOM
1065
CD
ARG
B
335
37.316
30.244
106.550
1.00
41.48
6

ATOM
1066
NE
ARG
B
335
36.829
29.299
105.552
1.00
45.90
7

ATOM
1067
CZ
ARG
B
335
37.450
28.206
105.136
1.00
47.90
6

ATOM
1068
NH1
ARG
B
335
38.622
27.895
105.663
1.00
48.82
7

ATOM
1069
NH2
ARG
B
335
36.902
27.417
104.214
1.00
47.30
7

ATOM
1070
N
SER
B
336
41.031
30.358
103.416
1.00
23.50
7

ATOM
1071
CA
SER
B
336
42.210
29.580
103.570
1.00
22.24
6

ATOM
1072
C
SER
B
336
43.358
30.478
103.130
1.00
20.50
6

ATOM
1073
O
SER
B
336
44.438
30.454
103.721
1.00
20.92
8

ATOM
1074
CB
SER
B
336
42.156
28.287
102.768
1.00
22.76
6

ATOM
1075
OG
SER
B
336
41.969
28.552
101.390
1.00
26.43
8

ATOM
1076
N
TYR
B
337
43.118
31.293
102.075
1.00
20.56
7

ATOM
1077
CA
TYR
B
337
44.099
32.211
101.494
1.00
20.39
6

ATOM
1078
C
TYR
B
337
44.572
33.168
102.501
1.00
20.26
6

ATOM
1079
O
TYR
B
337
45.771
33.406
102.657
1.00
18.58
8

ATOM
1080
CB
TYR
B
337
43.532
32.993
100.338
1.00
20.73
6

ATOM
1081
CG
TYR
B
337
43.852
32.189
99.151
1.00
20.00
6

ATOM
1082
CD1
TYR
B
337
45.060
32.300
98.520
1.00
19.20
6

ATOM
1083
CD2
TYR
B
337
42.898
31.287
98.708
1.00
18.26
6

ATOM
1084
CE1
TYR
B
337
45.333
31.482
97.449
1.00
20.11
6

ATOM
1085
CE2
TYR
B
337
43.162
30.463
97.639
1.00
18.81
6

ATOM
1086
CZ
TYR
B
337
44.394
30.561
97.010
1.00
18.76
6

ATOM
1087
OH
TYR
B
337
44.690
29.740
95.950
1.00
21.89
8

ATOM
1088
N
GLY
B
338
43.638
33.720
103.251
1.00
20.86
7

ATOM
1089
CA
GLY
B
338
43.953
34.698
104.265
1.00
21.55
6

ATOM
1090
C
GLY
B
338
43.695
36.045
103.618
1.00
21.71
6

ATOM
1091
O
GLY
B
338
44.521
36.961
103.673
1.00
23.64
8

ATOM
1092
N
ILE
B
339
42.526
36.135
102.977
1.00
20.19
7

ATOM
1093
CA
ILE
B
339
42.229
37.339
102.256
1.00
17.89
6

ATOM
1094
C
ILE
B
339
40.826
37.495
101.770
1.00
17.77
6

ATOM
1095
O
ILE
B
339
39.985
36.578
101.759
1.00
17.95
8

ATOM
1096
CB
ILE
B
339
43.114
37.421
100.997
1.00
16.61
6

ATOM
1097
CG1
ILE
B
339
42.682
36.303
100.058
1.00
17.70
6

ATOM
1098
CG2
ILE
B
339
44.577
37.285
101.345
1.00
15.97
6

ATOM
1099
CD1
ILE
B
339
43.095
36.516
98.623
1.00
18.76
6

ATOM
1100
N
PRO
B
340
40.643
38.716
101.356
1.00
18.40
7

ATOM
1101
CA
PRO
B
340
39.378
39.039
100.834
1.00
18.85
6

ATOM
1102
C
PRO
B
340
38.833
38.168
99.767
1.00
20.47
6

ATOM
1103
O
PRO
B
340
39.235
37.066
99.417
1.00
20.43
8

ATOM
1104
CB
PRO
B
340
39.484
40.498
100.459
1.00
21.51
6

ATOM
1105
CG
PRO
B
340
40.300
41.028
101.584
1.00
21.02
6

ATOM
1106
CD
PRO
B
340
41.087
39.867
102.138
1.00
20.38
6

ATOM
1107
N
TYR
B
341
37.855
38.871
99.290
1.00
19.86
7

ATOM
1108
CA
TYR
B
341
36.973
38.491
98.291
1.00
20.61
6

ATOM
1109
C
TYR
B
341
35.904
39.604
98.183
1.00
21.47
6

ATOM
1110
O
TYR
B
341
35.267
39.906
99.191
1.00
22.73
8

ATOM
1111
CB
TYR
B
341
36.350
37.149
98.693
1.00
19.26
6

ATOM
1112
CG
TYR
B
341
35.521
36.752
97.553
1.00
19.28
6

ATOM
1113
CD1
TYR
B
341
36.113
36.701
96.325
1.00
20.55
6

ATOM
1114
CD2
TYR
B
341
34.149
36.503
97.674
1.00
17.12
6

ATOM
1115
CE1
TYR
B
341
35.364
36.410
95.214
1.00
19.33
6

ATOM
1116
CE2
TYR
B
341
33.388
36.240
96.568
1.00
17.88
6

ATOM
1117
CZ
TYR
B
341
34.005
36.193
95.325
1.00
19.65
6

ATOM
1118
OH
TYR
B
341
33.276
35.940
94.192
1.00
19.58
8

ATOM
1119
N
ILE
B
342
35.748
40.219
96.993
1.00
20.40
7

ATOM
1120
CA
ILE
B
342
34.757
41.266
96.746
1.00
17.21
6

ATOM
1121
C
ILE
B
342
34.189
41.048
95.371
1.00
17.08
6

ATOM
1122
O
ILE
B
342
34.921
40.832
94.395
1.00
13.95
8

ATOM
1123
CB
ILE
B
342
35.361
42.686
96.796
1.00
18.65
6

ATOM
1124
CG1
ILE
B
342
35.697
43.100
98.225
1.00
19.16
6

ATOM
1125
CG2
ILE
B
342
34.414
43.692
96.165
1.00
16.96
6

ATOM
1126
CD1
ILE
B
342
36.549
44.346
98.309
1.00
15.59
6

ATOM
1127
N
GLU
B
343
32.877
41.091
95.266
1.00
15.73
7

ATOM
1128
CA
GLU
B
343
32.177
40.894
94.003
1.00
16.49
6

ATOM
1129
C
GLU
B
343
32.016
42.246
93.273
1.00
15.41
6

ATOM
1130
O
GLU
B
343
31.543
43.208
93.881
1.00
14.98
8

ATOM
1131
CB
GLU
B
343
30.854
40.175
94.248
1.00
16.75
6

ATOM
1132
CG
GLU
B
343
31.005
38.776
94.836
1.00
21.78
6

ATOM
1133
CD
GLU
B
343
29.866
37.855
94.510
1.00
23.12
6

ATOM
1134
OE1
GLU
B
343
28.745
38.347
94.255
1.00
26.37
8

ATOM
1135
OE2
GLU
B
343
30.078
36.623
94.511
1.00
24.53
8

ATOM
1136
N
THR
B
344
32.387
42.334
91.973
1.00
13.00
7

ATOM
1137
CA
THR
B
344
32.351
43.614
91.228
1.00
11.49
6

ATOM
1138
C
THR
B
344
31.711
43.542
89.838
1.00
12.27
6

ATOM
1139
O
THR
B
344
31.422
42.459
89.336
1.00
9.62
8

ATOM
1140
CB
THR
B
344
33.792
44.112
90.956
1.00
10.85
6

ATOM
1141
OG1
THR
B
344
34.463
43.173
90.106
1.00
6.78
8

ATOM
1142
CG2
THR
B
344
34.550
44.273
92.254
1.00
8.15
6

ATOM
1143
N
SER
B
345
31.472
44.690
89.216
1.00
11.09
7

ATOM
1144
CA
SER
B
345
30.976
44.719
87.827
1.00
13.01
6

ATOM
1145
C
SER
B
345
31.542
45.927
87.098
1.00
14.26
6

ATOM
1146
O
SER
B
345
30.972
47.023
87.174
1.00
13.73
8

ATOM
1147
CB
SER
B
345
29.466
44.750
87.743
1.00
14.15
6

ATOM
1148
OG
SER
B
345
29.041
44.858
86.395
1.00
13.24
8

ATOM
1149
N
ALA
B
346
32.660
45.781
86.408
1.00
13.33
7

ATOM
1150
CA
ALA
B
346
33.220
46.904
85.669
1.00
12.18
6

ATOM
1151
C
ALA
B
346
32.136
47.551
84.804
1.00
13.44
6

ATOM
1152
O
ALA
B
346
32.363
48.596
84.196
1.00
13.49
8

ATOM
1153
CB
ALA
B
346
34.378
46.454
84.787
1.00
10.34
6

ATOM
1154
N
LYS
B
347
30.962
46.906
84.763
1.00
12.65
7

ATOM
1155
CA
LYS
B
347
29.857
47.359
83.912
1.00
15.70
6

ATOM
1156
C
LYS
B
347
29.010
48.385
84.592
1.00
15.47
6

ATOM
1157
O
LYS
B
347
28.598
49.367
83.964
1.00
16.65
8

ATOM
1158
CB
LYS
B
347
28.963
46.185
83.472
1.00
19.13
6

ATOM
1159
CG
LYS
B
347
27.673
46.627
82.800
1.00
20.67
6

ATOM
1160
CD
LYS
B
347
27.126
45.557
81.849
1.00
24.06
6

ATOM
1161
CE
LYS
B
347
25.916
46.033
81.054
1.00
26.11
6

ATOM
1162
NZ
LYS
B
347
25.201
44.895
80.406
1.00
29.99
7

ATOM
1163
N
THR
B
348
28.745
48.185
85.852
1.00
16.90
7

ATOM
1164
CA
THR
B
348
27.909
49.132
86.527
1.00
17.62
6

ATOM
1165
C
THR
B
348
28.724
49.884
87.548
1.00
20.92
6

ATOM
1166
O
THR
B
348
28.405
50.990
87.988
1.00
24.25
8

ATOM
1167
CB
THR
B
348
26.788
48.377
87.212
1.00
15.61
6

ATOM
1168
OG1
THR
B
348
27.338
47.446
88.141
1.00
20.18
8

ATOM
1169
CG2
THR
B
348
25.949
47.635
86.176
1.00
15.65
6

ATOM
1170
N
ARG
B
349
29.783
49.187
87.889
1.00
20.17
7

ATOM
1171
CA
ARG
B
349
30.729
49.659
88.856
1.00
19.87
6

ATOM
1172
C
ARG
B
349
30.452
49.101
90.217
1.00
19.65
6

ATOM
1173
O
ARG
B
349
30.739
49.729
91.238
1.00
21.24
8

ATOM
1174
CB
ARG
B
349
30.738
51.183
88.911
1.00
21.41
6

ATOM
1175
CG
ARG
B
349
29.915
51.862
87.832
1.00
23.33
6

ATOM
1176
CD
ARG
B
349
30.103
53.364
87.882
1.00
26.23
6

ATOM
1177
NE
ARG
B
349
29.333
54.046
86.849
1.00
29.02
7

ATOM
1178
CZ
ARG
B
349
29.856
54.885
85.964
1.00
28.12
6

ATOM
1179
NE1
ARG
B
349
31.157
55.144
85.986
1.00
29.44
7

ATOM
1180
NH2
ARG
B
349
29.081
55.461
85.056
1.00
26.81
7

ATOM
1181
N
GLN
B
350
29.900
47.909
90.237
1.00
19.31
7

ATOM
1182
CA
GLN
B
350
29.647
47.320
91.491
1.00
20.61
6

ATOM
1183
C
GLN
B
350
30.958
47.037
92.199
1.00
18.91
6

ATOM
1184
O
GLN
B
350
31.787
46.255
91.707
1.00
20.14
8

ATOM
1185
CB
GLN
B
350
28.863
46.030
91.334
1.00
22.74
6

ATOM
1186
CG
GLN
B
350
28.811
45.172
92.581
1.00
28.13
6

ATOM
1187
CD
GLN
B
350
28.112
43.870
92.279
1.00
33.79
6

ATOM
1188
OE1
GLN
B
350
27.228
43.823
91.432
1.00
35.61
8

ATOM
1189
NE2
GLN
B
350
28.340
42.703
92.853
1.00
36.94
7

ATOM
1190
N
GLY
B
351
31.147
47.666
93.347
1.00
15.77
7

ATOM
1191
CA
GLY
B
351
32.301
47.446
94.178
1.00
14.29
6

ATOM
1192
C
GLY
B
351
33.644
47.596
93.494
1.00
16.18
6

ATOM
1193
O
GLY
B
351
34.615
46.970
93.917
1.00
16.35
8

ATOM
1194
N
VAL
B
352
33.734
48.431
92.449
1.00
15.01
7

ATOM
1195
CA
VAL
B
352
35.038
48.627
91.788
1.00
16.69
6

ATOM
1196
C
VAL
B
352
36.066
49.312
92.705
1.00
18.61
6

ATOM
1197
O
VAL
B
352
37.268
49.011
92.666
1.00
18.11
8

ATOM
1198
CB
VAL
B
352
34.924
49.433
90.453
1.00
16.08
6

ATOM
1199
CG1
VAL
B
352
36.297
49.789
89.913
1.00
14.40
6

ATOM
1200
CG2
VAL
B
352
34.142
48.625
89.422
1.00
13.93
6

ATOM
1201
N
GLU
B
353
35.584
50.216
93.522
1.00
20.53
7

ATOM
1202
CA
GLU
B
353
36.397
50.913
94.475
1.00
22.53
6

ATOM
1203
C
GLU
B
353
36.769
50.019
95.611
1.00
21.83
6

ATOM
1204
O
GLU
B
353
37.951
49.812
95.920
1.00
22.92
8

ATOM
1205
CB
GLU
B
353
35.593
52.033
95.125
1.00
24.74
6

ATOM
1206
CG
GLU
B
353
35.794
53.394
94.551
1.00
30.79
6

ATOM
1207
CD
GLU
B
353
35.144
54.396
95.450
1.00
33.69
6

ATOM
1208
OE1
GLU
B
353
35.511
54.464
96.634
1.00
37.05
8

ATOM
1209
OE2
GLU
B
353
34.258
55.121
94.959
1.00
35.15
8

ATOM
1210
N
ASP
B
354
35.752
49.509
96.230
1.00
21.41
7

ATOM
1211
CA
ASP
B
354
36.122
48.698
97.329
1.00
21.01
6

ATOM
1212
C
ASP
B
354
37.239
47.781
96.949
1.00
20.27
6

ATOM
1213
O
ASP
B
354
38.269
47.720
97.623
1.00
17.50
8

ATOM
1214
CB
ASP
B
354
34.970
47.914
97.845
1.00
24.36
6

ATOM
1215
CG
ASP
B
354
34.995
48.038
99.330
1.00
30.77
6

ATOM
1216
OD1
ASP
B
354
35.665
47.203
99.993
1.00
33.05
8

ATOM
1217
OD2
ASP
B
354
34.336
48.956
99.861
1.00
31.44
8

ATOM
1218
N
ALA
B
355
37.039
47.068
95.866
1.00
17.49
7

ATOM
1219
CA
ALA
B
355
38.023
46.136
95.458
1.00
15.18
6

ATOM
1220
C
ALA
B
355
39.415
46.748
95.446
1.00
16.54
6

ATOM
1221
O
ALA
B
355
40.322
46.156
96.032
1.00
18.35
8

ATOM
1222
CB
ALA
B
355
37.698
45.567
94.085
1.00
15.15
6

ATOM
1223
N
PHE
B
356
39.616
47.904
94.803
1.00
15.85
7

ATOM
1224
CA
PHE
B
356
40.940
48.508
94.696
1.00
16.22
6

ATOM
1225
C
PHE
B
356
41.396
49.169
95.995
1.00
17.66
6

ATOM
1226
O
PHE
B
356
42.571
49.084
96.362
1.00
14.98
8

ATOM
1227
CB
PHE
B
356
40.961
49.522
93.559
1.00
15.23
6

ATOM
1228
CG
PHE
B
356
41.158
48.905
92.202
1.00
14.51
6

ATOM
1229
CD1
PHE
B
356
42.427
48.602
91.713
1.00
14.99
6

ATOM
1230
CD2
PHE
B
356
40.054
48.645
91.402
1.00
12.98
6

ATOM
1231
CE1
PHE
B
356
42.591
48.051
90.446
1.00
14.46
6

ATOM
1232
CE2
PHE
B
356
40.209
48.093
90.132
1.00
15.29
6

ATOM
1233
CZ
PHE
B
356
41.483
47.796
89.654
1.00
12.95
6

ATOM
1234
N
TYR
B
357
40.467
49.834
96.680
1.00
19.54
7

ATOM
1235
CA
TYR
B
357
40.770
50.522
97.932
1.00
20.37
6

ATOM
1236
C
TYR
B
357
41.050
49.544
99.063
1.00
19.02
6

ATOM
1237
O
TYR
B
357
41.887
49.811
99.927
1.00
20.01
8

ATOM
1238
CB
TYR
B
357
39.640
51.486
98.312
1.00
21.80
6

ATOM
1239
CG
TYR
B
357
39.631
52.753
97.483
1.00
23.79
6

ATOM
1240
CD1
TYR
B
357
40.662
53.027
96.582
1.00
25.01
6

ATOM
1241
CD2
TYR
B
357
38.602
53.683
97.607
1.00
26.46
6

ATOM
1242
CE1
TYR
B
357
40.673
54.191
95.831
1.00
28.21
6

ATOM
1243
CE2
TYR
B
357
38.604
54.857
96.859
1.00
30.15
6

ATOM
1244
CZ
TYR
B
357
39.644
55.103
95.974
1.00
30.94
6

ATOM
1245
OH
TYR
B
357
39.666
56.266
95.237
1.00
34.33
8

ATOM
1246
N
THR
B
358
40.354
48.409
99.044
1.00
17.62
7

ATOM
1247
CA
THR
B
358
40.553
47.379
100.055
1.00
15.39
6

ATOM
1248
C
THR
B
358
41.936
46.757
99.879
1.00
13.79
6

ATOM
1249
O
THR
B
358
42.572
46.345
100.851
1.00
16.35
8

ATOM
1250
CB
THR
B
358
39.474
46.290
99.968
1.00
15.92
6

ATOM
1251
OG1
THR
B
358
38.185
46.879
100.189
1.00
16.52
8

ATOM
1252
CG2
THR
B
358
39.714
45.212
101.009
1.00
16.77
6

ATOM
1253
N
LEU
B
359
42.410
46.708
98.638
1.00
10.71
7

ATOM
1254
CA
LEU
B
359
43.730
46.158
98.364
1.00
10.63
6

ATOM
1255
C
LEU
B
359
44.790
47.134
98.867
1.00
10.52
6

ATOM
1256
O
LEU
B
359
45.825
46.722
99.386
1.00
11.97
8

ATOM
1257
CB
LEU
B
359
43.911
45.900
96.870
1.00
6.43
6

ATOM
1258
CG
LEU
B
359
45.262
45.313
96.457
1.00
4.47
6

ATOM
1259
CD1
LEU
B
359
45.542
44.017
97.214
1.00
7.62
6

ATOM
1260
CD2
LEU
B
359
45.258
45.074
94.957
1.00
6.43
6

ATOM
1261
N
VAL
B
360
44.517
48.425
98.706
1.00
12.43
7

ATOM
1262
CA
VAL
B
360
45.418
49.486
99.160
1.00
12.53
6

ATOM
1263
C
VAL
B
360
45.569
49.435
100.682
1.00
12.35
6

ATOM
1264
O
VAL
B
360
46.675
49.554
101.209
1.00
11.56
8

ATOM
1265
CB
VAL
B
360
44.871
50.876
98.763
1.00
12.07
6

ATOM
1266
CG1
VAL
B
360
45.701
51.991
99.400
1.00
11.14
6

ATOM
1267
CG2
VAL
B
360
44.864
51.015
97.254
1.00
14.35
6

ATOM
1268
N
ARG
B
361
44.447
49.274
101.376
1.00
11.63
7

ATOM
1269
CA
ARG
B
361
44.439
49.198
102.834
1.00
15.50
6

ATOM
1270
C
ARG
B
361
45.174
47.947
103.291
1.00
15.39
6

ATOM
1271
O
ARG
B
361
45.841
47.953
104.319
1.00
17.95
8

ATOM
1272
CB
ARG
B
361
43.003
49.171
103.353
1.00
16.24
6

ATOM
1273
CG
ARG
B
361
42.224
50.420
103.015
1.00
21.26
6

ATOM
1274
CD
ARG
B
361
40.801
50.342
103.518
1.00
25.92
6

ATOM
1275
NE
ARG
B
361
40.053
51.545
103.173
1.00
26.30
7

ATOM
1276
CZ
ARG
B
361
39.014
51.572
102.346
1.00
25.63
6

ATOM
1277
NH1
ARG
B
361
38.586
50.455
101.775
1.00
25.03
7

ATOM
1278
NH2
ARG
B
361
38.410
52.722
102.086
1.00
26.64
7

ATOM
1279
N
GLU
B
362
45.030
46.881
102.506
1.00
18.13
7

ATOM
1280
CA
GLU
B
362
45.697
45.614
102.777
1.00
15.00
6

ATOM
1281
C
GLU
B
362
47.213
45.767
102.722
1.00
14.50
6

ATOM
1282
O
GLU
B
362
47.926
45.285
103.586
1.00
14.64
8

ATOM
1283
CB
GLU
B
362
45.232
44.541
101.791
1.00
16.54
6

ATOM
1284
CG
GLU
B
362
45.699
43.136
102.136
1.00
24.18
6

ATOM
1285
CD
GLU
B
362
44.656
42.348
102.906
1.00
24.52
6

ATOM
1286
OE1
GLU
B
362
43.634
42.946
103.304
1.00
29.72
8

ATOM
1287
OE2
GLU
B
362
44.861
41.134
103.111
1.00
29.14
8

ATOM
1288
N
ILE
B
363
47.670
46.490
101.696
1.00
13.62
7

ATOM
1289
CA
ILE
B
363
49.098
46.752
101.513
1.00
14.51
6

ATOM
1290
C
ILE
B
363
49.612
47.607
102.660
1.00
18.09
6

ATOM
1291
O
ILE
B
363
50.695
47.362
103.188
1.00
17.21
8

ATOM
1292
CB
ILE
B
363
49.381
47.499
100.189
1.00
13.80
6

ATOM
1293
CG1
ILE
B
363
48.919
46.663
98.989
1.00
11.48
6

ATOM
1294
CG2
ILE
B
363
50.871
47.815
100.068
1.00
12.40
6

ATOM
1295
CD1
ILE
B
363
49.046
47.380
97.653
1.00
10.17
6

ATOM
1296
N
ARG
B
364
48.821
48.609
103.038
1.00
20.25
7

ATOM
1297
CA
ARG
B
364
49.170
49.518
104.127
1.00
24.82
6

ATOM
1298
C
ARG
B
364
49.318
48.752
105.446
1.00
25.29
6

ATOM
1299
O
ARG
B
364
50.225
49.020
106.241
1.00
27.02
8

ATOM
1300
CB
ARG
B
364
48.100
50.613
104.243
1.00
27.21
6

ATOM
1301
CG
ARG
B
364
48.426
51.754
105.196
1.00
30.99
6

ATOM
1302
CD
ARG
B
364
47.361
52.841
105.113
1.00
35.30
6

ATOM
1303
NE
ARG
B
364
46.017
52.323
105.384
1.00
39.11
7

ATOM
1304
CZ
ARG
B
364
44.891
52.859
104.916
1.00
39.38
6

ATOM
1305
NH1
ARG
B
364
44.925
53.940
104.144
1.00
41.49
7

ATOM
1306
NH2
ARG
B
364
43.725
52.313
105.223
1.00
41.33
7

ATOM
1307
N
GLN
B
365
48.435
47.782
105.656
1.00
25.79
7

ATOM
1308
CA
GLN
B
365
48.424
46.986
106.894
1.00
27.70
6

ATOM
1309
C
GLN
B
365
49.620
46.087
107.025
1.00
29.58
6

ATOM
1310
O
GLN
B
365
50.130
45.778
108.114
1.00
31.20
8

ATOM
1311
CB
GLN
B
365
47.181
46.095
106.944
1.00
29.53
6

ATOM
1312
CG
GLN
B
365
45.868
46.852
107.089
1.00
31.95
6

ATOM
1313
CD
GLN
B
365
44.645
46.031
106.720
1.00
35.63
6

ATOM
1314
OE1
GLN
B
365
44.752
44.850
106.371
1.00
32.96
8

ATOM
1315
NE2
GLN
B
365
43.382
46.444
106.724
1.00
35.21
7

ATOM
1316
N
HIS
B
366
50.021
45.688
105.838
1.00
30.22
7

ATOM
1317
CA
HIS
B
366
51.123
44.795
105.582
1.00
30.69
6

ATOM
1318
C
HIS
B
366
52.475
45.543
105.678
1.00
31.24
6

ATOM
1319
O
HIS
B
366
53.422
45.038
106.284
1.00
31.93
8

ATOM
1320
CB
HIS
B
366
50.829
44.130
104.254
1.00
31.85
6

ATOM
1321
CG
HIS
B
366
51.892
43.130
103.835
1.00
35.22
6

ATOM
1322
ND1
HIS
B
366
52.789
43.401
102.823
1.00
35.30
7

ATOM
1323
CD2
HIS
B
366
52.203
41.893
104.291
1.00
34.70
6

ATOM
1324
CE1
HIS
B
366
53.606
42.373
102.673
1.00
35.81
6

ATOM
1325
NE2
HIS
B
366
53.272
41.446
103.552
1.00
36.63
7

ATOM
1326
PG
GNP
$
1380
42.807
39.954
78.851
1.00
8.68
15

ATOM
1327
O1G
GNP
$
1380
43.395
39.015
80.005
1.00
8.34
8

ATOM
1328
O2G
GNP
$
1380
42.997
39.263
77.587
1.00
11.57
8

ATOM
1329
O3G
GNP
$
1380
43.676
41.101
78.946
1.00
13.99
8

ATOM
1330
N3B
GNP
$
1380
41.222
40.232
79.146
1.00
7.92
7

ATOM
1331
PB
GNP
$
1380
40.622
41.012
80.468
1.00
8.51
15

ATOM
1332
O1B
GNP
$
1380
40.631
40.224
81.725
1.00
9.22
8

ATOM
1333
O2B
GNP
$
1380
41.154
42.379
80.644
1.00
10.55
8

ATOM
1334
O3A
GNP
$
1380
39.082
41.193
80.101
1.00
10.51
8

ATOM
1335
PA
GNP
$
1380
38.413
42.583
79.491
1.00
9.87
15

ATOM
1336
O1A
GNP
$
1380
38.420
43.677
80.506
1.00
7.44
8

ATOM
1337
O2A
GNP
$
1380
38.965
42.868
78.142
1.00
13.51
8

ATOM
1338
O5*
GNP
$
1380
36.910
42.062
79.346
1.00
8.97
8

ATOM
1339
C5*
GNP
$
1380
36.520
41.047
78.395
1.00
10.25
6

ATOM
1340
C4*
GNP
$
1380
35.053
41.226
77.960
1.00
11.24
6

ATOM
1341
O4*
GNP
$
1380
34.180
41.173
79.119
1.00
11.67
8

ATOM
1342
C3*
GNP
$
1380
34.841
42.619
77.313
1.00
11.16
6

ATOM
1343
O3*
GNP
$
1380
33.887
42.627
76.221
1.00
19.79
8

ATOM
1344
C2*
GNP
$
1380
34.324
43.431
78.498
1.00
11.63
6

ATOM
1345
O2*
GNP
$
1380
33.508
44.570
78.167
1.00
8.36
8

ATOM
1346
C1*
GNP
$
1380
33.466
42.404
79.238
1.00
8.70
6

ATOM
1347
N9
GNP
$
1380
33.326
42.740
80.671
1.00
8.66
7

ATOM
1348
C8
GNP
$
1380
34.314
43.075
81.566
1.00
6.11
6

ATOM
1349
N7
GNP
$
1380
33.899
43.320
82.743
1.00
8.97
7

ATOM
1350
C5
GNP
$
1380
32.538
43.148
82.661
1.00
10.36
6

ATOM
1351
C6
GNP
$
1380
31.550
43.287
83.661
1.00
12.02
6

ATOM
1352
O6
GNP
$
1380
31.711
43.601
84.850
1.00
14.72
8

ATOM
1353
N1
GNP
$
1380
30.270
43.018
83.152
1.00
9.31
7

ATOM
1354
C2
GNP
$
1380
29.979
42.659
81.852
1.00
11.23
6

ATOM
1355
N2
GNP
$
1380
28.694
42.440
81.564
1.00
8.24
7

ATOM
1356
N3
GNP
$
1380
30.923
42.531
80.915
1.00
9.36
7

ATOM
1357
C4
GNP
$
1380
32.170
42.789
81.391
1.00
9.70
6

ATOM
1358
MG
MG
$
1373
41.839
43.269
77.994
1.00
34.76
12

END

	Number	Date	Country
Parent	PCT/GB01/03810	Aug 2001	US
Child	10371617	Feb 2003	US

Crystal structure of a Ras-P13K complex

Information

Publication Number

Date Filed

Date Published

Inventors

CPC

US Classifications

International Classifications

Abstract

Description

Claims

Priority Claims (1)

RELATED APPLICATIONS

Continuations (1)