Claims
- 1. A compound selected from the group consisting of compounds:
- 2. A composition comprising:
(A) an active agent; and (B) at least one compound of claim 1.
- 3. The composition of claim 2, wherein the active agent is selected from the group consisting of a biologically active agent, a chemically active agent, and a combination thereof.
- 4. The composition of claim 3, wherein the biologically active agent comprises at least one protein, polypeptide, peptide, hormome, polysaccharide, mucopolysaccharide, carbohydrate, or lipid.
- 5. The composition of claim 3, wherein the biologically active agent is selected from the group consisting of: growth hormones, human growth hormones (hGH), recombinant human growth hormones (rhGH), bovine growth hormones, porcine growth hormones, growth hormone-releasing hormones, interferons, α-interferon, β-interferon, γ-interferon, interleukin-1, interleukin-2, insulin, porcine insulin, bovine insulin, human insulin, human recombinant insulin, insulin-like growth factor(IGF), IGF-1, heparin, unfractionated heparin, heparinoids, dermatans, chondroitins, low molecular weight heparin, very low molecular weight heparin, ultra low molecular weight heparin, unfractionated heparin, heparinoids, dermatans, chondroitins, low molecular weight heparin, very low molecular weight heparin, ultra low molecular weight heparin, calcitonin, salmon calcitonin human calcitonin; erythropoietin (EPO), atrial naturetic factor, antigens, monoclonal antibodies, somatostatin, protease inhibitors, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, leutinizing-hormone-releasing-hormone, follicle stimulating hormone, glucocerebrosidase, thrombopoietin, filgrastim, prostaglandins, cyclosporin, vasopressin, cromolyn sodium, sodium chromoglycate, disodium chromoglycate, vancomycin, desferrioxamine (DFO), parathyroid hormone (PTH), fragments of PTH, antimicrobials, antibiotics, antibacterials, anti-fungal agents, daptomycin, vitamins; analogs, fragments, mimetics and polyethylene glycol (PEG)-modified derivatives of these compounds; and any combination thereof.
- 6. The composition of claim 3, wherein the biologically active agent comprises hGH, cromolyn sodium, sodium chromoglycate, disodium chromoglycate, insulin, porcine insulin, bovine insulin, human insulin, human recombinant insulin, insulin-like growth factor(IGF), IGF-1, antimicrobials, antibiotics, antibacterial agents, anti-fungal agents, daptomycin, analogs, fragments, mimetics and polyethylene glycol (PEG)-modified derivatives of these compounds, or combinations thereof.
- 7. The composition of claim 3, wherein the biologically active agent comprises cromolyn sodium.
- 8. The composition of claim 3, wherein the biologically active agent comprises is heparin.
- 9. The composition of claim 3, wherein the biologically active agent comprises insulin.
- 10. The composition of claim 3, wherein the biologically active agent comprises human growth hormone.
- 11. A dosage unit form comprising:
(A) the composition of claim 2; and (B) (a) an excipient
(b) a diluent, (c) a disintegrant, (d) a lubricant, (e) a plasticizer, (f) a colorant (g) a dosing vehicle, or (h) any combination thereof.
- 12. The dosage unit form of claim 11, wherein the active agent is selected from the group consisting of a biologically active agent, a chemically active agent, and a combination thereof.
- 13. The dosage unit form of claim 12, wherein the biologically active agent comprises at least one protein, polypeptide, peptide, hormone, polysaccharide, mucopolysaccharide, carbohydrate, or lipid.
- 14. The dosage unit form of claim 12, wherein the biologically active agent is selected from the group consisting of:
growth hormones, human growth hormones (hGH), recombinant human growth hormones (rhGH), bovine growth hormones, porcine growth hormones, growth hormone-releasing hormones, interferons, α-interferon, β-interferon, γ-interferon, interleukin-1, interleukin-2, insulin, porcine insulin, bovine insulin, human insulin, human recombinant insulin, insulin-like growth factor(IGF), IGF-1, heparin, unfractionated heparin, heparinoids, dermatans, chondroitins, low molecular weight heparin, very low molecular weight heparin, ultra low molecular weight heparin, calcitonin, salmon calcitonin human calcitonin; erythropoietin (EPO), atrial naturetic factor, antigens, monoclonal antibodies, somatostatin, protease inhibitors, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, leutinizing-hormone-releasing-hormone, follicle stimulating hormone, glucocerebrosidase, thrombopoietin, filgrastim, prostaglandins, cyclosporin, vasopressin, cromolyn sodium, sodium chromoglycate, disodium chromoglycate, vancomycin, desferrioxamine (DFO), parathyroid hormone (PTH), fragments of PTH, antimicrobials, antibiotics, antibacterials, anti-fungal agents, daptomycin, vitamins; analogs, fragments, mimetics and polyethylene glycol (PEG)-modified derivatives of these compounds; and any combination thereof.
- 15. The dosage unit form of claim 12, wherein the biologically active agent comprises hGH, cromolyn sodium, sodium chromoglycate, disodium chromoglycate, insulin, porcine insulin, bovine insulin, human insulin, human recombinant insulin, insulin-like growth factor(IGF), IGF-1, antimicrobials, antibiotics, antibacterial agents, anti-fungal agents, daptomycin, analogs, fragments, mimetics and polyethylene glycol (PEG)-modified derivatives of these compounds, or combinations thereof.
- 16. The dosage unit form of claim 11, wherein the dosage unit form is in the form of a tablet, a capsule, a particle, a powder, a sachet, or a liquid.
- 17. The dosage unit form of claim 11, wherein the dosing vehicle is a liquid selected from the group consisting of water, 25% aqueous propylene glycol, phosphate buffer, 1,2-propane diol, ethanol, and any combination thereof.
- 18. A method for administering an active agent to an animal in need of the agent, the method comprising administering orally to the animal the composition of claim 2.
- 19. A method for preparing a composition comprising mixing:
(A) at least one active agent; (B) the compound of claim 1; and (C) optionally, a dosing vehicle.
- 20. A compound selected from the group consisting of
- 21. A composition comprising:
(A) an active agent; and (B) a delivery agent selected from the group consisting of the compounds of claim 20, salts thereof, and mixtures thereof.
- 22. The composition of claim 21, wherein the active agent comprises at least one protein, polypeptide, peptide, hormone, polysaccharide, mucopolysaccharide, carbohydrate, or lipid.
- 23. A method for preparing a composition comprising mixing:
(A) at least one active agent; (B) the compound of claim 20; and (C) optionally, a dosing vehicle.
Parent Case Info
[0001] This application claims the benefit of U.S. Provisional Application Nos. 60/230,331 and 60/237,235, filed Sep. 6, 2000 and Oct. 2, 2000, respectively, both of which are herein incorporated by reference.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/US01/41984 |
9/5/2001 |
WO |
|