Patent Grant
9498363
Some embodiments relate in part to endovascular prostheses and methods of deploying same. Embodiments may be directed more specifically to stent grafts and methods of making and deploying same within the body of a patient.
An aneurysm is a medical condition indicated generally by an expansion and weakening of the wall of an artery of a patient. Aneurysms can develop at various sites within a patient's body. Thoracic aortic aneurysms (TAAs) or abdominal aortic aneurysms (AAAs) are manifested by an expansion and weakening of the aorta which is a serious and life threatening condition for which intervention is generally indicated. Existing methods of treating aneurysms include invasive surgical procedures with graft replacement of the affected vessel or body lumen or reinforcement of the vessel with a graft.
Surgical procedures to treat aortic aneurysms can have relatively high morbidity and mortality rates due to the risk factors inherent to surgical repair of this disease as well as long hospital stays and painful recoveries. This is especially true for surgical repair of TAAs, which is generally regarded as involving higher risk and more difficulty when compared to surgical repair of AAAs. An example of a surgical procedure involving repair of a AAA is described in a book titled Surgical Treatment of Aortic Aneurysms by Denton A. Cooley, M.D., published in 1986 by W. B. Saunders Company.
Due to the inherent risks and complexities of surgical repair of aortic aneurysms, endovascular repair has become a widely-used alternative therapy, most notably in treating AAAs. Early work in this field is exemplified by Lawrence, Jr. et al. in “Percutaneous Endovascular Graft: Experimental Evaluation”, Radiology (May 1987) and by Mirich et al. in “Percutaneously Placed Endovascular Grafts for Aortic Aneurysms: Feasibility Study,” Radiology (March 1989). Commercially available endoprostheses for the endovascular treatment of AAAs include the AneuRx® stent graft manufactured by Medtronic, Inc. of Minneapolis, Minn., the Zenith® stent graft system sold by Cook, Inc. of Bloomington, Ind., the PowerLink® stent-graft system manufactured by Endologix, Inc. of Irvine, Calif., and the Excluder® stent graft system manufactured by W.L. Gore & Associates, Inc. of Newark, Del. A commercially available stent graft for the treatment of TAAs is the TAG™ system manufactured by W.L. Gore & Associates, Inc.
When deploying devices by catheter or other suitable instrument, it is advantageous to have a flexible and low profile stent graft and delivery system for passage through the various guiding catheters as well as the patient's sometimes tortuous anatomy. Many of the existing endovascular devices and methods for treatment of aneurysms, while representing significant advancement over previous devices and methods, use systems having relatively large transverse profiles, often up to 24 French. Also, such existing systems have greater than desired lateral stiffness, which can complicate the delivery process. In addition, the sizing of stent grafts may be important to achieve a favorable clinical result. In order to properly size a stent graft, the treating facility typically must maintain a large and expensive inventory of stent grafts in order to accommodate the varied sizes of patient vessels due to varied patient sizes and vessel morphologies. Alternatively, intervention may be delayed while awaiting custom size stent grafts to be manufactured and sent to the treating facility. As such, minimally invasive endovascular treatment of aneurysms is not available for many patients that would benefit from such a procedure and can be more difficult to carry out for those patients for whom the procedure is indicated.
What have been needed are stent graft systems and methods that are adaptable to a wide range of patient anatomies and that can be safely and reliably deployed using a flexible low profile system.
Some embodiments are directed to a delivery system for an inflatable endoluminal prosthesis having a delivery catheter. In some embodiments, the delivery catheter may have an elongate shaft including a proximal section and a fill tube including a fill tube lumen extending axially within the fill tube. In some cases, the endoluminal prosthesis may be releasably secured to the proximal section of the delivery catheter. The endoluminal prosthesis may include an inflatable portion with an interior volume in fluid communication with an inflation port which may be releasably coupled to a proximal end of the fill tube. In some embodiments, a fill tube retention mechanism may releasably secure the fill tube lumen of the fill tube in fluid communication with the inflation port. The fill tube retention mechanism may have a tab which is disposed at a distal end of the endoluminal prosthesis in substantially fixed relation to the inflation port and which may include an aperture in the tab which is separated from the inflation port by a predetermined distance in some embodiments. In some embodiments, a fitting may be secured to a proximal portion of the fill tube of the delivery catheter which may extend laterally from the fill tube and which may include at least a portion that is sized to pass through the aperture in the tab. In some instances, the tab may be disposed a distance from a proximal end of the fill tube which allows the fill tube to be engaged with the inflation port while the fitting may be disposed within the aperture in the tab. A fitting may include a passage through the fitting in some embodiments. In some cases, a release wire having an outer transverse dimension and axial bending stiffness that allows the release wire to pass through the passage of the fitting may assist in mechanically capturing the tab to the fitting. The tab may be disposed between the release wire and the fill tube with the release wire disposed in the passage in some embodiments. In some cases, the tab includes PTFE material.
Some embodiments of the delivery catheter for delivery of an inflatable endoluminal prosthesis may include an elongate shaft having a proximal section and a fill tube. In some cases, the fill tube may include a fill tube lumen in fluid communication with a distal section of the elongate shaft and extending axially therein. In addition, a fitting may be secured to a proximal portion of the fill tube of the delivery catheter which may extend laterally from the fill tube and which may include at least a portion that may be sized to pass through an aperture in a tab of an endoluminal prosthesis in some embodiments. In some cases, the tab may be disposed a distance from a proximal end of the fill tube which may be configured to allow the fill tube to be engaged with an inflation port of an inflatable endoluminal prosthesis. The fitting may have a passage through the fitting in some embodiments. In some cases, a release wire including an outer transverse dimension and axial bending stiffness that allows the release wire to pass through the passage of the fitting may mechanically capture a tab of an endoluminal prosthesis to the fitting. The tab may be disposed between the release wire and the fill tube with the release wire disposed in the passage in some embodiments. In some cases, the passage of the fitting includes an axial passage which is substantially parallel to the lumen of the fill tube. In some instances, the release wire extends from the fitting to a distal end of the catheter and is coupled to a release mechanism which is disposed at a distal end of the delivery catheter and which is configured to apply axial tension and displacement to the release wire in order to axially retract the release wire and release the fitting from an aperture of a tab of an endoluminal prosthesis. For some embodiments, the fill tube may include a plurality of fittings, a plurality of release wires, a transverse dimension of about 1 mm to about 2 mm or both. In some cases, an outer transverse dimension of the fill tube may be configured to slide within an inner lumen of a inflation port of an endoluminal prosthesis and provide a seal therebetween for viscous fluids.
Some embodiments are directed to a method of releasably securing a fill tube of a delivery catheter to an inflation port of an inflatable portion of an inflatable endoluminal prosthesis. The method may include delivering an endoluminal prosthesis to a treatment site with the endoluminal prosthesis being releasably secured to a proximal section of a delivery catheter. In some embodiments, the endoluminal prosthesis may include an inflatable portion with an interior volume in fluid communication with an inflation port. A proximal end of a fill tube of the delivery catheter may be releasably coupled to the inflation port with a fill tube retention mechanism that releasably secures the fill tube lumen of the fill tube in fluid communication with the inflation port in some embodiments. In some cases, the fitting may be released from the tab by retracting the release wire from the passage such that the tab may be no longer mechanically captured over the fitting between the fill tube and the release wire. The fill tube retention mechanism may include a flexible tab disposed at a distal end of the endoluminal prosthesis in fixed relation to the inflation port and may include an aperture in the tab which may be separated from the inflation port by a predetermined distance in some embodiments. In some cases, the fill tube retention mechanism may further include a fitting secured to a proximal portion of the fill tube of the delivery catheter which may extend laterally from the fill tube and include at least a portion that may be sized to pass through the aperture in the tab. Furthermore, the fitting may be positioned a distance from a proximal end of the fill tube such that it may allow the fill tube to be engaged with the inflation port while the fitting may be disposed within the aperture in some embodiments. In some instances, the fitting may include a passage through the fitting which may be positioned so as to allow the tab to be disposed between the release wire and the fill tube with the release wire disposed in the passage. In some embodiments, the fill tube retention mechanism may further include a release wire having an outer transverse dimension and axial bending stiffness that allows the release wire to pass through the passage of the fitting and mechanically capture the tab to the fitting. In some cases, the elongate shaft may further include a retractable outer sheath that is disposed over the elongate release wire sleeve and is configured to removably cover a constrained endoluminal prosthesis disposed on the proximal section of the elongate shaft. In some instances, the delivery catheter may further include a proximal nosecone having a bullet-shaped profile and a shoulder portion with an outer surface which is configured to slidingly accept an inner luminal surface of the outer sheath.
Some embodiments are directed to a delivery catheter for delivery of an endoluminal prosthesis having an elongate shaft with sufficient column strength for percutaneous advancement within a patient's body lumen. The elongate shaft may include a proximal section and a lumen extending therein in some embodiments. In some instances, a plurality of releasable belts disposed on the proximal section of the elongate shaft may be configured to releasably constrain a self-expanding member of an endoluminal prosthesis. In some embodiments, a plurality of elongate release members may be in communication with a distal end of the elongate shaft and may include a proximal section configured to releasably secure at least one respective releasable belt while said releasable belt is in a configuration that constrains at least a portion of an endoluminal prosthesis. The elongate shaft may have an elongate release wire sleeve disposed within the lumen extending within the elongate shaft in some cases. Additionally, the elongate release wire sleeve may include a low friction material and extend from a distal section to a proximal section of the elongate shaft. The elongate release wire sleeve may include a separate lumen for each release member in some embodiments.
Some embodiments are directed to a delivery system for percutaneous delivery of and endoluminal prosthesis, including an elongate shaft with sufficient column strength for percutaneous advancement within a patient's body lumen. The elongate shaft may include a proximal section and a lumen extending therein in some embodiments. In some instances, a plurality of releasable belts disposed on the proximal section of the elongate shaft may be configured to releasably constrain a self-expanding member of an endoluminal prosthesis. In some embodiments, a plurality of elongate release members may be in communication with a distal end of the elongate shaft and may include a proximal section configured to releasably secure at least one respective releasable belt while said releasable belt may be in a configuration that constrains at least a portion of an endoluminal prosthesis. In some cases, the elongate shaft may include an elongate release wire sleeve disposed within the lumen extending within the elongate shaft. Additionally, the elongate release wire sleeve may include a low friction material extending from a distal section to a proximal section of the elongate shaft in some embodiments. The elongate release wire sleeve may include a separate lumen for each release member in some cases. An endoluminal prosthesis may include a tubular body portion of flexible material and a self-expanding member secured to a proximal end of the tubular body member in some embodiments. The endoluminal prosthesis may be releasably secured to the proximal section of the delivery catheter by the releasable belts disposed about and releasably constraining the self-expanding member of the endoluminal prosthesis in some embodiments. In some cases, the endoluminal prosthesis further includes an inflatable portion with an interior volume in fluid communication with an inflation port and a proximal end of the fill tube of the catheter releasably coupled to the inflation port. In some instances, the tubular body portion has a bifurcated configuration. Also, the low friction material of the elongate release wire sleeve may include a fluoropolymer such as PTFE. For some such embodiments, the PTFE of the elongate release wire sleeve may include a shore hardness of about 40 D to about 70 D and the elongate release member may include an elongate release wire or both. In some cases, the delivery catheter may be configured to deliver an inflatable endovascular prosthesis wherein the delivery catheter may further include a fill tube including a fill tube lumen extending axially within the elongate shaft. In some instances, the elongate shaft may include a guidewire lumen extending from a distal section to a proximal end thereof. For some embodiments, the elongate shaft may include an elongate multi-lumen member extending from a distal section of the elongate shaft to a proximal section of the elongate shaft, the multi-lumen member having a guidewire lumen and a lumen within which the elongate release wire sleeve is disposed. In some cases, the elongate shaft may further include a retractable outer sheath that is disposed over the elongate release wire sleeve and that is configured to removably cover a constrained endoluminal prosthesis disposed on the proximal section of the elongate shaft. In some instances, the delivery system may further include a proximal nosecone including a bullet-shaped profile and a shoulder portion having an outer surface which is configured to slidingly accept an inner luminal surface of the outer sheath.
Some embodiments are directed to a delivery catheter for delivery of an inflatable endoluminal prosthesis including an elongate shaft which may have sufficient column strength for percutaneous advancement within a patient's body lumen. In some embodiments, the elongate shaft may include a proximal section which may be configured to accept an inflatable endoluminal prosthesis releasably secured thereto. Additionally, a fill lumen may be in fluid communication with a distal section of the elongate shaft and may extend to the proximal section of the elongate shaft in some embodiments. Some embodiments may include a collapsible low profile fill tube including an inner lumen which may be in fluid communication with the fill lumen of the elongate shaft. In some embodiments, the collapsible fill tube may be collapsed to substantially eliminate a volume of the inner lumen which may have a proximal end configured to couple to a inflation port of an inflatable endoluminal prosthesis. In some cases, elongate shaft may include an elongate multi-lumen member which extends from a distal section of the elongate shaft to a proximal section of the elongate shaft, which may have at least a guidewire lumen and the fill lumen and which may include a fill tube cavity in a proximal end thereof configured to accept a section of the collapsible low profile fill tube that has been axially compressed and shortened. In some instances, the fill tube cavity may include a substantially cylindrical cavity having an inner transverse dimension configured to be disposed about the collapsible low profile fill tube in an axially compressed state. For some embodiments, the collapsible low profile fill tube may include a fluoropolymer such as PTFE, which may or may not be sintered, may have a shore hardness of about 25 D to about 40 D, or any combination of these features. In some cases, the elongate shaft may include a guidewire lumen extending from a distal section to a proximal end thereof. In some instances, the elongate shaft may further include a retractable outer sheath that is disposed over the collapsible low profile fill tube and fill lumen of the elongate shaft during delivery of an endoluminal prosthesis to a treatment site and is configured to removably cover a constrained endoluminal prosthesis disposed on the proximal section of the elongate shaft. For some embodiments, the delivery catheter may include a proximal nose cone having a bullet-shaped profile and a shoulder portion with an outer surface which is configured to slidingly accept an inner luminal surface of the outer sheath. In some cases, the collapsible low profile fill tube in a non-collapsed state may have an inner lumen with a nominal transverse dimension of about 0.5 mm to about 5 mm, may have a wall thickness of about 0.02 mm to about 0.13 mm and may have an axial length of about 5 mm to about 100 mm. In some instances, the collapsible low profile fill tube may have a substantially rigid proximal end configured to be releasably coupled to an inflation port of an inflatable endoluminal prosthesis.
Some embodiments are directed to a delivery system for percutaneous delivery of and endoluminal prosthesis including a delivery catheter for delivery of an inflatable endoluminal prosthesis and an inflatable endoluminal prosthesis releasably secured to the proximal section of the elongate shaft in a constrained state. In some embodiments, the prosthesis may include an inflatable portion with an interior volume in fluid communication with an inflation port. A proximal end of the fill tube of the catheter may be releasably coupled to the inflation port in some embodiments. The inflatable endoluminal prosthesis may include an elongate shaft with sufficient column strength for percutaneous advancement within a patient's body lumen. Additionally, the elongate shaft may include a proximal section which may be configured to accept an inflatable endoluminal prosthesis releasably secured thereto in some embodiments. A fill lumen may be in fluid communication with a distal section of the elongate shaft and extend to the proximal section of the elongate shaft in some cases. In some instances, a collapsible low profile fill tube including an inner lumen may be in fluid communication with the fill lumen of the elongate shaft. The collapsible fill tube may be collapsed to substantially eliminate a volume of the inner lumen and may have a proximal end configured to couple to a inflation port of an inflatable endoluminal prosthesis in some embodiments. For some embodiments, the inflatable endoluminal prosthesis may include a tubular body portion with a bifurcated configuration. In some cases, elongate shaft may include an elongate multi-lumen member which extends from a distal section of the elongate shaft to a proximal section of the elongate shaft, which may have at least a guidewire lumen and the fill lumen and which may include a fill tube cavity in a proximal end thereof configured to accept a section of the collapsible low profile fill tube that has been axially compressed and shortened. In some instances, the fill tube cavity may include a substantially cylindrical cavity having an inner transverse dimension configured to be disposed about the collapsible low profile fill tube in an axially compressed state. For some embodiments, the collapsible low profile fill tube may include a fluoropolymer such as PTFE, which may or may not be sintered, may have a shore hardness of about 25 D to about 40 D, or any combination of these features. In some cases, the elongate shaft may include a guidewire lumen extending from a distal section to a proximal end thereof. In some instances, the elongate shaft may further include a retractable outer sheath that is disposed over the collapsible low profile fill tube and fill lumen of the elongate shaft during delivery of an endoluminal prosthesis to a treatment site and is configured to removably cover a constrained endoluminal prosthesis disposed on the proximal section of the elongate shaft. For some embodiments, the delivery catheter may include a proximal nose cone having a bullet-shaped profile and a shoulder portion with an outer surface which is configured to slidingly accept an inner luminal surface of the outer sheath. In some cases, the collapsible low profile fill tube in a non-collapsed state may have an inner lumen with a nominal transverse dimension of about 0.5 mm to about 5 mm, may have a wall thickness of about 0.02 mm to about 0.13 mm and may have an axial length of about 5 mm to about 100 mm. In some instances, the collapsible low profile fill tube may have a substantially rigid proximal end configured to be releasably coupled to an inflation port of an inflatable endoluminal prosthesis.
Some embodiments are directed to a delivery catheter for delivery of an endoluminal prosthesis, including an elongate shaft with sufficient column strength for percutaneous advancement within a patient's body lumen. In some embodiments, the elongate shaft may include a proximal section and a distal section. Additionally, a plurality of releasable belts may be disposed at the proximal section of the elongate shaft which may be configured to releasably constrain at least one self-expanding member of an endoluminal prosthesis in some cases. A first elongate release member may be secured to a distal actuator member at the distal section of the elongate shaft, which may include a proximal section configured to releasably secure at least one respective releasable belt held in a constraining configuration by the first elongate release member. In addition, the first elongate release member may be configured to release with the respective releasable belt upon axial retraction of the release member or release wire in a distal direction by a first actuation length that may be substantially the length the first release member or release wire extends proximally beyond the junction between the first release member and the releasable belt in some embodiments. Additionally, a second elongate release member may be secured to the distal actuator member at the distal section of the elongate shaft, which may include a proximal section configured to releasably secure at least one respective releasable belt held in a constraining configuration by the second elongate release member. In some embodiments, the second elongate release member may be configured to release with the respective releasable belt upon axial retraction of the second elongate release member in a distal direction by a second actuation length that may be substantially the length the second elongate release member extends proximally beyond the junction between the second release member and the respective releasable belt. In some instances, a flexible tether may secure the second elongate release member to the distal actuator. The flexible tether may include an axial slack in its length which may be as long as or longer than the actuation length of the first elongate release member in some embodiments. In some cases, the delivery catheter may also include an elongate release wire sleeve disposed within a lumen extending within the elongate shaft, the elongate release wire sleeve including a low friction material and extending from a distal section of the elongate shaft to a proximal section of the elongate shaft and the elongate release wire sleeve also including a separate lumen for each elongate release member. In some instances, the delivery catheter may be configured to deliver an inflatable endovascular prosthesis wherein the delivery catheter also includes a fill tube having a fill tube lumen extending axially within the elongate shaft. For some embodiments, the elongate shaft may include a guidewire lumen extending from a distal section to a proximal end thereof. In some cases, the elongate shaft may include an elongate multi-lumen member extending from a distal section of the elongate shaft to a proximal section of the elongate shaft. The multi-lumen member may also have a guidewire lumen and a lumen within which the release wire sleeve is disposed. In some instances, the elongate shaft may further include a retractable outer sheath that is configured to removably cover a constrained endoluminal prosthesis disposed on the proximal section of the elongate shaft. For some embodiments, the delivery catheter may also include a proximal nose cone having a bullet-shaped profile and a shoulder portion with an outer surface which is configured to slidingly accept an inner luminal surface of the outer sheath.
Some embodiments are directed to a delivery system for percutaneous delivery of and endoluminal prosthesis, including an elongate shaft with sufficient column strength for percutaneous advancement within a patient's body lumen. In some embodiments, the elongate shaft may include a proximal section, a distal section and a plurality of releasable belts disposed at the proximal section of the elongate shaft which are configured to releasably constrain at least one self-expanding member of an endoluminal prosthesis. A first elongate release member or release wire may be secured to a distal actuator member at the distal section of the elongate shaft, which may include a proximal section configured to releasably secure at least one respective releasable belt held in a constraining configuration by the first elongate release member. In some embodiments, the first elongate release member may be configured to release with the respective releasable belt upon axial retraction of the release member or release wire in a distal direction by a first actuation length that may be substantially the length the first release member extends proximally beyond the junction between the first release member and the releasable belt. In some instances, a second elongate release member may be secured to the distal actuator member at the distal section of the elongate shaft, which may include a proximal section configured to releasably secure at least one respective releasable belt held in a constraining configuration by the second elongate release member and which may be configured to release with the respective releasable belt upon axial retraction of the second elongate release member. In some embodiments, the second elongate release member may be released in a distal direction by a second actuation length that may be substantially the length the second elongate release member extends proximally beyond the junction between the second release member and the respective releasable belt. A flexible tether may secure the second elongate release member to the distal actuator in some embodiments. The flexible tether may include an axial slack in its length which may be as long as or longer than the actuation length of the first elongate release member in some cases. In some embodiments, an endoluminal prosthesis may include a tubular graft body portion of flexible material and at least one self-expanding member secured to a proximal end of the tubular body member. The endoluminal prosthesis may be releasably secured to the proximal section of the elongate shaft by the releasable belts disposed about and releasably constraining at least one self-expanding member of the endoluminal prosthesis in some embodiments. In some cases, the delivery catheter may also include an elongate release wire sleeve disposed within a lumen extending within the elongate shaft, the elongate release wire sleeve including a low friction material and extending from a distal section of the elongate shaft to a proximal section of the elongate shaft and the elongate release wire sleeve also including a separate lumen for each elongate release member. In some instances, the delivery catheter may be configured to deliver an inflatable endovascular prosthesis wherein the delivery catheter also includes a fill tube having a fill tube lumen extending axially within the elongate shaft. For some embodiments, the elongate shaft may include a guidewire lumen extending from a distal section to a proximal end thereof. In some cases, the elongate shaft may include an elongate multi-lumen member extending from a distal section of the elongate shaft to a proximal section of the elongate shaft. The multi-lumen member may also have a guidewire lumen and a lumen within which the release wire sleeve is disposed. In some instances, the elongate shaft may further include a retractable outer sheath that is configured to removably cover a constrained endoluminal prosthesis disposed on the proximal section of the elongate shaft. For some embodiments, the delivery catheter may also include a proximal nose cone having a bullet-shaped profile and a shoulder portion with an outer surface which is configured to slidingly accept an inner luminal surface of the outer sheath.
Some embodiments are directed to a delivery catheter for delivery of an endoluminal prosthesis, including an elongate shaft with sufficient column strength for percutaneous advancement within a patient's body lumen. In some embodiments, the elongate shaft may include a proximal section and a distal section and a plurality of releasable belts disposed on the proximal section of the elongate shaft configured to releasably constrain a self-expanding member of an endoluminal prosthesis. A plurality of elongate release members may include a proximal section configured to releasably secure at least one respective releasable belt while the releasable belt may be in a configuration that constrains at least a portion of an endoluminal prosthesis. In some cases, a release mechanism may be disposed at the distal section of the elongate shaft and in operative connection with the release members. The release mechanism may include a stationary main body portion secured in fixed relation to the elongate shaft and a plurality of rotating actuator rings that may be coupled to at least one elongate release member in some embodiments. The release mechanism may be configured to axially retract the respective at least one elongate release member upon rotation of the respective rotating ring relative to the main body portion in some cases. In some cases, the rotating rings are configured to actuate the respective release members by a camming action. In some instances, each rotating actuator ring may include an axial position on the release mechanism that generally corresponds to an axial position of the releasable belt or belts on the proximal section the rotating actuator ring is configured to actuate. For some embodiments, the delivery catheter may include at least one proximal releasable belt on the proximal section of the elongate shaft configured to releasably constrain a proximal self-expanding member of an endoluminal prosthesis; a proximal rotating actuator ring disposed proximally of the main body portion of the release mechanism, coupled to a proximal elongate release member and configured to release the proximal releasable belt upon actuation; at least one distal releasable belt on the proximal section of the elongate shaft configured to releasably constrain a distal self-expanding member of an endoluminal prosthesis; and a distal rotating actuator ring disposed distally of the main body portion of the release mechanism, coupled to a distal elongate release member and configured to release the distal releasable belt upon actuation. In some cases, the elongate release members may include elongate release wires. In some instances, the delivery catheter may be configured to deliver an inflatable endovascular prosthesis wherein the delivery catheter also includes a fill tube having a fill tube lumen extending axially within the elongate shaft. For some embodiments, the elongate shaft may include a guidewire lumen extending from a distal section to a proximal end thereof. In some cases, the elongate shaft may include an elongate multi-lumen member extending from a distal section of the elongate shaft to a proximal section of the elongate shaft. The multi-lumen member may also have a guidewire lumen and a lumen within which the release wire sleeve is disposed. In some instances, the elongate shaft may further include a retractable outer sheath that is configured to removably cover a constrained endoluminal prosthesis disposed on the proximal section of the elongate shaft. For some embodiments, the delivery catheter may also include a proximal nose cone having a bullet-shaped profile and a shoulder portion with an outer surface which is configured to slidingly accept an inner luminal surface of the outer sheath.
Some embodiments are directed to a delivery catheter for delivery of an endoluminal prosthesis, including an elongate shaft having sufficient column strength for percutaneous advancement within a patient's body lumen. In some embodiments, the elongate shaft may include a proximal section and a distal section and at least one releasable belt disposed on the proximal section of the elongate shaft and configured to releasably constrain a self-expanding member of an endoluminal prosthesis. At least one elongate release member may include a proximal section configured to releasably secure the at least one releasable belt while said releasable belt may be in a configuration that constrains at least a portion of an endoluminal prosthesis. In some cases, a release mechanism may be disposed at the distal section of the elongate shaft in operative connection with the at least one release member. The release mechanism may include a stationary main body portion secured in fixed relation to the elongate shaft and at least one rotating actuator ring which may be coupled to the at least one elongate release member in some embodiments. The release mechanism may be configured to axially retract the at least one elongate release member upon rotation of the rotating ring relative to the main body portion in some cases.
Some embodiments are directed to a delivery system for percutaneous delivery of an endoluminal prosthesis, including an elongate shaft with sufficient column strength for percutaneous advancement within a patient's body lumen. In some embodiments, the elongate shaft may include a proximal section and a distal section and at least one releasable belt disposed on the proximal section of the elongate shaft and configured to releasably constrain a self-expanding member of an endoluminal prosthesis. At least one elongate release member including a proximal section configured to releasably secure the at least one releasable belt while said releasable belt may be in a configuration that constrains at least a portion of an endoluminal prosthesis in some embodiments. A release mechanism may be disposed at the distal section of the elongate shaft in operative connection with the at least one release member in some cases. The release mechanism may include a stationary main body portion secured in fixed relation to the elongate shaft and at least one rotating actuator ring which may be coupled to the at least one elongate release member. In some embodiments, the at least one rotating actuator ring may be configured to axially retract the at least one elongate release member upon rotation of the rotating ring relative to the main body portion. In some cases, an endoluminal prosthesis may include a tubular body portion of flexible material and a self-expanding member secured to a proximal end of the tubular body member. Additionally, the endoluminal prosthesis may be releasably secured to the proximal section of the delivery catheter by the releasable belts disposed about and releasably constraining the self-expanding member of the endoluminal prosthesis in some embodiments. In some cases, the rotating rings are configured to actuate the respective release members by a camming action. In some instances, each rotating actuator ring may include an axial position on the release mechanism that generally corresponds to an axial position of the releasable belt or belts on the proximal section the rotating actuator ring is configured to actuate. For some embodiments, the delivery catheter may include at least one proximal releasable belt on the proximal section of the elongate shaft configured to releasably constrain a proximal self-expanding member of an endoluminal prosthesis; a proximal rotating actuator ring disposed proximally of the main body portion of the release mechanism, coupled to a proximal elongate release member and configured to release the proximal releasable belt upon actuation; at least one distal releasable belt on the proximal section of the elongate shaft configured to releasably constrain a distal self-expanding member of an endoluminal prosthesis; and a distal rotating actuator ring disposed distally of the main body portion of the release mechanism, coupled to a distal elongate release member and configured to release the distal releasable belt upon actuation. In some cases, the elongate release members may include elongate release wires. In some instances, the delivery catheter may be configured to deliver an inflatable endovascular prosthesis wherein the delivery catheter also includes a fill tube having a fill tube lumen extending axially within the elongate shaft. For some embodiments, the elongate shaft may include a guidewire lumen extending from a distal section to a proximal end thereof. In some cases, the elongate shaft may include an elongate multi-lumen member extending from a distal section of the elongate shaft to a proximal section of the elongate shaft. The multi-lumen member may also have a guidewire lumen and a lumen within which the release wire sleeve is disposed. In some instances, the elongate shaft may further include a retractable outer sheath that is configured to removably cover a constrained endoluminal prosthesis disposed on the proximal section of the elongate shaft. For some embodiments, the delivery catheter may also include a proximal nose cone having a bullet-shaped profile and a shoulder portion with an outer surface which is configured to slidingly accept an inner luminal surface of the outer sheath.
Some embodiments are directed to a delivery system for percutaneous delivery of and endoluminal prosthesis, including an elongate shaft having sufficient column strength for percutaneous advancement within a patient's body lumen. In some embodiments, the elongate shaft may include a proximal section, a distal section and a retractable outer sheath extending from the proximal section to the distal section. The retractable outer sheath may be configured to removably cover a constrained endoluminal prosthesis disposed on the proximal section of the elongate shaft in some embodiments. A grip device may be disposed over a distal section of the outer sheath and may include an egg shaped elastomer body in some embodiments. In some cases, the egg shaped elastomer body may include a bore extending axially therethrough. The bore may have an inner transverse dimension configured to slide over an outer surface of the retractable outer sheath and make contact with and frictionally grip the outer surface of the outer retractable sheath when manually squeezed from an outside surface of the grip device in some embodiments. In some cases, the elastomer body of the grip device may include a longitudinal slot communicating with the bore and outside surface of the elastomer body and configured to allow the elastomer body to be spread open for lateral insertion or removal of the outer retractable sheath relative to the bore. In some instances, the elastomer body may include an elastomer having a shore hardness of about 20 A to about 40 A, a material selected from the group consisting of rubber, polyurethane and silicone or any combination of these features. For some embodiments, the elastomer body may include a major outer transverse dimension of about 15 mm to about 50 mm, an axial length of about 500 mm to about 700 mm or both. In some cases, the bore in the elastomer body may be configured to have clearance between an inner surface of the bore and an outer surface of the retractable outer sheath of up to about 2 mm. In some instances, the inner surface of the bore may have a coefficient of friction of about 0.6 to about 0.95.
Some embodiments are directed to a grip device configured to be disposed over a distal section of a retractable outer sheath of a delivery system for delivery of an endoluminal prosthesis. In some embodiments, the grip device may have an egg shaped elastomer body including a bore extending axially therethrough. The bore may have an inner transverse dimension configured to slide over an outer surface of a retractable outer sheath and make contact with and frictionally grip the outer surface of the outer retractable sheath when manually squeezed from an outside surface of the grip device in some embodiments. In some cases, the elastomer body of the grip device may include a longitudinal slot which communicates between the bore and an outside surface of the elastomer body and which is configured to allow the elastomer body to be spread open for lateral insertion or removal of an outer retractable sheath relative to the bore. In some instances, the elastomer body may include an elastomer having a shore hardness of about 20 A to about 40 A, a material selected from the group consisting of rubber, polyurethane and silicone or any combination of these features. For some embodiments, the elastomer body may include a major outer transverse dimension of about 15 mm to about 50 mm, an axial length of about 500 mm to about 700 mm or both. In some cases, the bore in the elastomer body may be configured to have clearance between an inner surface of the bore and an outer surface of the retractable outer sheath of up to about 2 mm. In some instances, the inner surface of the bore may have a coefficient of friction of about 0.6 to about 0.95.
Some embodiments are directed to a method of manually retracting a retractable outer sheath of a delivery system for delivery of an endoluminal prosthesis, including advancing a delivery system for percutaneous delivery of an endoluminal prosthesis to a treatment site within a patient's body lumen. Some methods may include manually grasping the grip device and applying inward radial pressure with the grip such that an inner luminal surface of the bore engages the outer surface of the retractable outer sheath. Additionally, some methods may include manually moving the grip device in an axial direction relative to the elongate shaft of the delivery system while the inner surface of the bore may be engaged with the outer surface of the retractable outer sheath. In some embodiments, the delivery system may include an elongate shaft with sufficient column strength for percutaneous advancement within a patient's body lumen. The elongate shaft may include a proximal section, a distal section and a retractable outer sheath extending from the proximal section to the distal section and configured to removably cover a constrained endoluminal prosthesis disposed on the proximal section of the elongate shaft in some embodiments. Additionally, a grip device may be disposed over a distal section of the outer sheath which may include an egg shaped elastomer body in some embodiments. The egg shaped elastomer body may include a bore extending axially therethrough. In some embodiments, the bore may have an inner transverse dimension configured to slide over an outer surface of the retractable outer sheath and make contact with and frictionally grip the outer surface of the outer retractable sheath when manually squeezed from an outside surface of the grip device. In some cases, the grip device may be axially moved in a distal direction relative to the elongate shaft until an endoluminal prosthesis in a constrained state disposed on a proximal section of the elongate shaft is fully exposed. In some instances, the delivery system may be advanced for percutaneous delivery of an endoluminal prosthesis to the treatment site within the patient's body lumen over a guidewire. For some device embodiments, the grip device may further include a longitudinal slot which communicates between the bore and an outside surface of the elastomer body and which is configured to allow the elastomer body to be spread open for lateral insertion or removal of the outer retractable sheath relative to the bore. In such cases, the method may also include spreading the longitudinal slot in the elastomer body and passing the retractable outer sheath through the longitudinal slot and into the bore.
Certain embodiments are described further in the following description, examples, claims and drawings.
The drawings illustrate embodiments of the invention and are not limiting. For clarity and ease of illustration, the drawings are not made to scale and, in some instances, various aspects may be shown exaggerated or enlarged to facilitate an understanding of particular embodiments.
Some embodiments may be directed generally to methods and devices for treatment of fluid flow vessels with the body of a patient. Treatment of blood vessels is specifically indicated for some embodiments, and, more specifically, treatment of aneurysms, such as abdominal aortic aneurysms.
Some embodiments of a modular endovascular graft assembly may include a bifurcated main graft member formed from a supple graft material, such as ePTFE, having a main fluid flow lumen therein. The main graft body member may also include an ipsilateral leg with an ipsilateral fluid flow lumen in communication with the main fluid flow lumen, a contralateral leg with a contralateral fluid flow lumen in communication with the main fluid flow lumen and a network of inflatable channels disposed on the main graft member. For some embodiments, the main graft body member may have an axial length of about 5 cm to about 10 cm, more specifically, about 6 cm to about 8 cm in order to span an aneurysm of a patient's aorta without engaging the patient's iliac arteries directly with the legs of the main graft member.
The inflatable channels of the network of inflatable channels may be disposed on any portion of the main graft body member including the ipsilateral and contralateral legs. The network of inflatable channels may be configured to accept a hardenable fill material to provide structural rigidity to the main graft body member when the network of inflatable channels are in an inflated state and the inflation material has been cured or hardened. Radiopaque inflation material may be used to facilitate monitoring of the fill process and subsequent engagement of graft extensions. The network of inflatable channels may also include at least one inflatable cuff disposed on a proximal portion of the main graft body member which is configured to seal against an inside surface of a patient's vessel, such as the aorta.
A proximal anchor member may be disposed at a proximal end of the main graft member and secured to the main graft body member. The proximal anchor member may have a self-expanding proximal stent portion secured to a distal self-expanding member having struts. Some embodiments of the struts may have a cross sectional area that may be substantially the same as or greater than a cross sectional area of proximal stent portions or distal stent portions adjacent the strut. Such a configuration may be useful in avoiding points of concentrated stress in the proximal anchor member or struts which couple components thereof. For some embodiments, the proximal stent of the proximal anchor member further includes a plurality of barbs having sharp tissue engaging tips that are configured to extend in a radial outward direction in a deployed expanded state. For some embodiments, the proximal anchor member includes a 4 crown proximal stent portion and a 8 crown distal stent portion which may be made from a superelastic alloy such as superelastic NiTi alloy.
At least one ipsilateral graft body extension having a fluid flow lumen disposed therein may be deployed with the fluid flow lumen of the graft body extension sealed to and in fluid communication with the fluid flow lumen of the ipsilateral leg of the main graft body member. In addition, at least one contralateral graft extension having a fluid flow lumen disposed therein may be deployed with the fluid flow lumen of the graft extension sealed to and in fluid communication with the fluid flow lumen of the contralateral leg of the main graft member. For some embodiments, the graft extensions may include an interposed self-expanding member disposed between at least one outer layer and at least one inner layer of supple layers of graft material. The interposed self-expanding member disposed between the outer layer and inner layer of graft material may be formed from an elongate resilient element helically wound with a plurality of longitudinally spaced turns into an open tubular configuration. For some embodiments, the interposed self-expanding member or stent may include a superelastic alloy such as superelastic NiTi alloy. In addition, the graft material of each graft body extension may further include at least one axial zone of low permeability for some embodiments.
For some embodiments, an outside surface of the graft extension may be sealed to an inside surface of the contralateral leg of the main graft when the graft extension is in a deployed state. For some embodiments, the axial length of the ipsilateral and contralateral legs may be sufficient to provide adequate surface area contact with outer surfaces of graft extensions to provide sufficient friction to hold the graft extensions in place. For some embodiments, the ipsilateral and contralateral legs may have an axial length of at least about 2 cm. For some embodiments, the ipsilateral and contralateral legs may have an axial length of about 2 cm to about 6 cm, more specifically, about 3 cm to about 5 cm.
With regard to graft embodiments discussed herein, such as graft assembly 10, and components thereof, as well as graft extensions, the term “proximal” refers to a location towards a patient's heart and the term “distal” refers to a location away from the patient's heart. With regard to delivery system catheters and components thereof discussed herein, the term “proximal” refers to a location that is disposed away from an operator who is using the catheter and the term “distal” refers to a location towards the operator.
Referring again to
In
For the particular endoluminal prosthesis 110 and inflation conduit configuration 150 shown in
A tab or flap extension 122 of the graft body of the prosthesis 110 may interlock with one or more fittings 124 of the fill tube assembly which may releasably secure the tubular members of the inflation conduit 150. In
For some embodiments, the inflatable portion of the endoluminal prosthesis 110 may include one or more inflatable channels formed from the flexible material of the graft body 126 section including the main graft body section and legs (not shown). The inflation conduit 150 may be disposed within an interior volume of a longitudinal inflatable channel 153 (see
When fill material is emitted under pressure from the outlet port of the inflation conduit 150, the fill material may first begin to fill a proximal inflatable cuff 151 (see
The inflation conduit 150, an inner lumen 158 of which may be in communication between a location outside the inflatable portion of the endoluminal prosthesis 110 and an interior volume of the inflatable portion, may be disposed within any desired portion of the inflatable portion. Inflation conduit 150 embodiments disposed within the interior volume of the inflatable portion may include a variety of configurations with regard to the size or area and position of the outlet port or ports. The inflation conduit 150 may have a single outlet port disposed at the proximal end of the inflation conduit 150. The outlet port may be disposed within the interior volume of the proximal inflatable cuff 151 disposed at the proximal end of the graft body 126 portion. The position of the outlet port may be configured to emit fill material injected into the inflation conduit 150 from the outlet port so as to first inflate the proximal inflatable cuff 151, as discussed above. The inflation conduit 150 may extend distally from the outlet port and may be disposed within the longitudinal inflatable channel 153 of the inflatable portion of the endoluminal prosthesis 110. The longitudinal inflatable channel may extend distally from the proximal inflatable cuff 151.
Some inflation conduit 150 embodiments may be made from a flexible, collapsible material, such as PTFE. For such embodiments, it may be desirable to have an elongate bead, not shown, disposed within an inner lumen 158 of the inflation conduit 150. Such a bead may be made from a flexible but substantially incompressible material, such as a solid PTFE extrusion with or without a radiopaque additive doping (bismuth, barium or other commonly used radiopaque extrusion additives). Bead embodiments may be useful for maintaining a patent lumen passage through the inflation conduit 150 when the endoluminal prosthesis 110 and inflatable portion thereof may be in a constrained state prior to deployment. This configuration may also allow the inflation conduit 150 of the endoluminal prosthesis 110 to be visible under fluoroscopy for orientation purposes throughout the deployment process prior to inflation of the inflatable portion with fill material. A distal end of the bead may be secured at any axial position within the inner lumen of the inflation conduit 150, but may also be secured to a distal portion of the inflation conduit 150.
In addition, at least the first release wire 118 and second release wire 119 may extend to and be in communication with a distal end of the elongate shaft 152. The first release wire 118 and second release wire 119 may have a proximal section configured to releasably secure at least one respective releasable belt, such as the first belt 112 and second belt 114, while the releasable belts are in a configuration that constrains at least a portion of the endoluminal prosthesis 110, such as the proximal self-expanding member 116. The elongate shaft 152 may have a multi-lumen elongate release wire sleeve 154 disposed therein which extends within the multi-lumen elongate shaft 152. The elongate release wire sleeve 154 may include or be made from a low friction material and extends from approximately a distal section 151 to a proximal section 153 of the elongate shaft 152. The low friction material may contain a fluoropolymer or a combination thereof, or contain PTFE for example. The PTFE may have a shore hardness of about 40 D to about 70 D. The elongate release wire sleeve 154 may have a separate lumen for each release member, such as a first lumen for the first release wire 118 and a second lumen for the second release wire 119. One or more elongate release members may include or be in connection with an elongate release wire 128.
The elongate shaft 152 may have a multi-lumen configuration, wherein one or more lumens are within the elongate shaft lumen 159. The elongate shaft lumen 159 may contain an elongate multi-lumen member which extends from a distal section 151 of the elongate shaft 152 to a proximal section 153 of the elongate shaft 152 (see also
The graft body 126 has a tubular body portion which generally may have a large transverse dimension and area. The graft body 126 may be made of a flexible material and has at least one proximal self-expanding member 116 secured to a proximal end of the tubular graft body 126 member. In addition, a proximal anchor member may also be disposed at a proximal end of the graft body 126. The proximal anchor member may include an additional proximal self-expanding member 116 that may be formed from at least one elongate element having a generally serpentine shape with, for example, four crowns or apices at either end. Each proximal apex or crown of the proximal self-expanding member 116 may be coupled to alternating distal crowns or apices of an additional 8 crown proximal self-expanding member 116. The distal end of the proximal self-expanding member 116 adjacent the graft body 126 may be formed from an elongate element having a generally serpentine shape. Additionally, the distal end of the proximal self-expanding member 116 adjacent the graft body 126 may be mechanically coupled to a connector ring (not shown) which may be embedded in the graft body 126 material approximately at the proximal end of the graft body 126, or directly coupled to perforations in the proximal edge region of the graft body 126. Embodiments of the connector ring may be generally circular in shape and may have regular undulations about the circumference that may be substantially sinusoidal in shape.
The proximal self-expanding member 116 may include outwardly extending barbs (not shown), that may be integrally formed with the struts and may have sharp tissue penetrating tips configured to penetrate into tissue of an inside surface of a lumen within which the proximal self-expanding member 116 may be deployed in an expanded state. Although the anchor members may include proximal and distal self-expanding members 116 and 117, similar expanding members may be used that are configured to be inelastically expanded with outward radial pressure as might be generated by the expansion of an expandable balloon from within either or both proximal and distal self-expanding members 116 and 117. The connector ring coupled to the proximal self-expanding member 116 may also be inelastically expandable.
The distal anchor member shown in
A collapsible low profile fill tube 108 embodiment may aid in reducing space within the delivery catheter 100 while in a constrained or collapsed state such as during packaging and transportation of the endoluminal prosthesis 110 to a treatment facility.
Within the elongate shaft 152, the fill tube lumen 164 contains a catheter fill tube 178 for fill material to be injected into the proximal end of the delivery catheter 100 system. The catheter fill tube 178 may be a rigid tube that may contain nylon, polyimide, PTFE or similar material or combinations thereof. The fill tube 108 may have a larger transverse radius than the catheter fill tube 178, thus permitting the fill tube 108 to slide over or couple to the catheter fill tube 178 to form a continuous tube such that the fill material may be injected or pushed through the catheter fill tube 178 and into the fill tube 108.
In some embodiments of the delivery catheter 100 and endoluminal prosthesis 110, there may be a multi-stage deployment embodiment of release wires that constrain the proximal and distal self-expanding members 116 and 117 of an endoluminal prosthesis 110. The multi-deployment embodiment involves multiple release wires with one belt being released at a time such that the anchor member or self-expanding member release forces are reduced. Anchor member or self-expanding member release forces may be compounded due to the anatomical path an endoluminal prosthesis 110 and delivery catheter 100 system navigate through. Reduction of the friction and load along the delivery pathway may be done by incorporating a low friction surface or lumen around each release wire. Catheter element embodiments having a multi-lumen configuration, such as dual lumens or tri-lumens may provide low frictional surfaces and separate lumens for each of the release wires to reduce stent release forces.
A rotating handle embodiment 500 of a distal adapter 102 of a delivery catheter 100 system is shown in
The rotating handle embodiment 500 may also have a fill polymer port 520, a grip 522, and a guide wire hemostatic valve 524 with a flush 526. The one or more rings 502 may rotate to pull the stent release wires 210, 212 and 310, 312 generally only in one direction relative to the handle embodiment 500. The release wires 210, 212 and 310, 312 may be spring loaded with a wire/ring released spring. Each ring 502 may have a cam 530 feature with a swaged end on the associated release wire. The ring 502 may have threaded components, such as a threaded shaft 532, that translate rotation into axial release wire 210, 212 and 310, 312 movement. The handle embodiment 500 design may incorporate a short throw concept where the release wire 210, 212 and 310, 312 ends may be released within up to about 5 cm of the belt. The handle embodiment 500 may be constructed in a variety of methods, for example, six or more pieces of the handle embodiment 500 may rotate relative to the handle 504 and control the actuation of any number of release wires. The pieces may include a threaded shaft 532, two or more cams 530, and the four rings 502.
A grip embodiment 600 may aid a physician in retracting the outer sheath 104 of a delivery catheter 100 system. During the endovascular procedure, retraction of the sheath 104 may be difficult due to the impacted forces of the delivery catheter 100 and slippery conditions during the procedure. The grip embodiment 600 may aid a physician in gripping and holding onto the delivery catheter 100.
The inner surface 602 of the bore may be configured to have clearance between an inner surface 602 of the bore and an outer surface of the retractable outer sheath 104 of up to about 2 mm. Additionally, in some cases, the inner surface 602 of the bore may be configured to have no clearance between an inner surface 602 of the bore and an outer surface of the retractable outer sheath 104. The inner surface 602 of the bore may have a coefficient of friction of about 0.6 to about 0.95. The grip 600 may have an optional axial slit or longitudinal slot 606 in communication with the inner surface 602 of the bore which allows easy placement onto and removal from the delivery catheter 100. The longitudinal slot 606 may be spread in order to allow the grip 600 to be placed over a part of the delivery catheter 100 for lateral insertion or removal of the outer retractable sheath 104 relative to the inner surface 602 of the bore.
The entirety of each patent, patent application, publication and document referenced herein hereby is incorporated by reference. Citation of the above patents, patent applications, publications and documents is not an admission that any of the foregoing is pertinent prior art, nor does it constitute any admission as to the contents or date of these publications or documents.
Modifications may be made to the foregoing without departing from the basic aspects of the embodiments discussed. Although embodiments have been described in substantial detail with reference to one or more specific embodiments, those of ordinary skill in the art will recognize that changes may be made to the embodiments specifically disclosed in this application, yet these modifications and improvements are within the scope and spirit of the disclosure.
Embodiments illustratively described herein suitably may be practiced in the absence of any element(s) not specifically disclosed herein. Thus, for example, in each instance herein any of the terms “comprising,” “consisting essentially of,” and “consisting of” may be replaced with either of the other two terms. The terms and expressions which have been employed are used as terms of description and not of limitation and use of such terms and expressions do not exclude any equivalents of the features shown and described or portions thereof, and various modifications are possible. The term “a” or “an” can refer to one of or a plurality of the elements it modifies (e.g., “a reagent” can mean one or more reagents) unless it is contextually clear either one of the elements or more than one of the elements is described. Thus, it should be understood that although embodiments have been specifically disclosed by representative embodiments and optional features, modification and variation of the concepts herein disclosed may be resorted to by those skilled in the art, and such modifications and variations are considered within the scope of this disclosure.
Certain embodiments are set forth in the claim(s) that follow(s).
This application claims priority under 35 U.S.C. 119(e) from U.S. Provisional Patent Application No. 61/621,286, filed Apr. 6, 2012, by J. Watson et al., titled Delivery Catheter for Endovascular Device, which is incorporated by reference herein in its entirety.
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| Number | Date | Country | |
|---|---|---|---|
| 20130268048 A1 | Oct 2013 | US |
| Number | Date | Country | |
|---|---|---|---|
| 61621286 | Apr 2012 | US |
