Claims
- 1. A compound of the formula: ##STR7## wherein: X represents an atom of chlorine, bromine, iodine or an alkyl group having 1 to 4 carbon atoms;
- R.sup.1 and R.sup.2, equal or different from each other, represent a hydrogen atom or an alkyl group or a hydroxyalkyl group, said groups having 1 to 6 carbon atoms;
- R represents a group selected from: ##STR8## wherein: R.sup.3 represents a hydrogen atom or an alkyl group, R.sup.4 and R.sup.5, equal or different from each other, represent a hydrogen atom or an alkyl, an hydroxyalkyl, mercaptoalkyl, alkylaryl, or phenyl group, wherein the alkyl groups have up to 6 carbon atoms and each phenyl group may have an OH substituent and
- Z represents an OH,
- NH--CH.sub.2 CONH--CH.sub.2 COOH or
- --O--CH.sub.2 --COOH or a pharmaceutically acceptable salt of said compound.
- 2. The compound of claim 1 wherein its acid group is salified with a non-toxic cation.
- 3. The compound of claim 1 wherein it contains a basic group salified with a non-toxic anion.
- 4. A pharmaceutical preparation useful in the therapy of hyperlipaemia and of hypercholesterolemia, characterized in that it contains a hypolipaemic or hypocholesterolmeic effective dose of at least one of the compounds of claim 5 associated or combined with one or more usual excipients or solvents.
- 5. The compound of claim 1 which is (2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl propanoyl) aminoacetic acid.
- 6. The compound of claim 1 which is (2-(4-(4-chlorobenzoyl)-phenoxy)-2-methyl propanoyl)amino acetyl amino acetic acid.
- 7. The compound of claim 1 which is N-(2-(4-(4-chlorobenzoyl)-phenoxy)-2-methyl propanoyl)-DL-2-amino-2-methylacetic acid.
- 8. The compound of claim 1 which is N-(2-(4-(4-chlorobenzoyl)-phenoxy)-2-methyl propanoyl)-N-methyl-2-amino acetic acid.
- 9. The compound of claim 1 which is N-(2-(4-(4-chlorobenzoyl)-phenoxy)-2-methyl propanoyl)-L-2-amino-2-p-hydroxyphenylmethyl acetic acid.
- 10. The compound of claim 1 which is N-(2-(4-(4-chlorobenzoyl)-phenoxy)-2-methyl propanoyl)-L-2-amino-2-hydroxymethyl acetic acid.
- 11. The compound of claim 1 which is 2-(4-(4-chlorobenzoyl)-phenoxy)-2-hydroxymethyl propionic acid.
- 12. The compound of claim 1 which is N-(2-(4-(4-chlorobenzoyl)-phenoxy)-2-methyl propanoyl)-DL-2-amino-2-benzylacetic acid.
Priority Claims (2)
Number |
Date |
Country |
Kind |
3426 A/78 |
May 1978 |
ITX |
|
3630 A/78 |
Dec 1978 |
ITX |
|
Parent Case Info
This is a division of application Ser. No. 123,454 filed Feb. 21, 1980, now U.S. Pat. No. 4,296,125 which in turn is a continuation of application Ser. No. 29,006 filed Apr. 11, 1979, now abandoned.
US Referenced Citations (5)
Foreign Referenced Citations (1)
Number |
Date |
Country |
2948095 |
Jun 1981 |
DEX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
123454 |
Feb 1980 |
|
Continuations (1)
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Number |
Date |
Country |
Parent |
29006 |
Apr 1979 |
|