1. Technical Field
The present invention relates to a nuclear medicine diagnosis device utilizing radiation and, in particular, the present invention relates to a detector array substrate and a nuclear medicine diagnosis device using the same suitable for Positron Emission computed Tomography (hereafter referred to as “PET”), or the like.
2. Background Art
A device for administering drugs labeled with an RI (a radioisotope) to a subject such as a patient, detecting γ-ray emitted from the RI, and acquiring RI distribution in the subject is generally called a nuclear medicine imaging device. A typical one of the nuclear medicine imaging device includes a γ-camera, a single photon emission computed tomography (SPECT) device, a PET device or the like.
The γ-camera is a device for measuring γ-ray emitted from inside of the subject by a plane-type detector, and imaging plane distribution thereof, and is attached with a collimator at the front of the detector to limit an incident direction of γ-ray to give directionality.
The SPECT is a device for detecting γ-ray emitted from inside of the subject by arranging plane-type detectors similar to the γ-camera around the subject, and imaging a body axis tomography image etc. of RI distribution, by imaging processing similarly to an X-ray CT. The SPECT, similarly as in the γ-camera, is also attached with a collimator at the front of the detector to limit an incident direction of γ-ray. The RI to be used in the SPECT is a nuclide emitting single γ-ray, and for example, 99mTc or 123I or the like is used, and circulation among organs and metabolism information can be known by imaging these RI distributions.
The PET device is a device for detecting γ-ray emitted from inside of the subject by a ring-like detector arranged at the circumference of the subject, and imaging a body axis tomography image or the like of RI distribution by imaging processing. Pair annihilation γ-ray of 511 keV are used as detection targets, which are emitted in nearly opposite direction) (180°±0.6° in annihilation by emitting β+ and binding with an electron, by administering radioactive drugs labeled with a positron (β+) emission nuclide.
The PET device can estimate incident directions of two annihilation γ-ray, when γ-ray detected at the same timing are selected by a coincidence circuit, therefore, unlike the γ-camera and the SPECT, it is not necessary to use a mechanical collimator. The positron emission nuclide to be used in PET imaging includes 18F, 15O, 11C or the like. For example, because a tumor tissue has fierce glucose metabolism and accumulates highly glucose, when a fluorodeoxyglucose (2-[F-18]fluoro-2-deoxy-D-glucose, 18F-FDG), which is a drug (a kind of glucose) labeled with 18F, is administered into the subject, 18F of a tracer also accumulates at the tumor tissue. From a PET image of this time, a tumor site can be specified quantitatively.
Conventionally, in the nuclear medicine diagnosis device, as a detector for detecting γ-ray, a scintillator mainly composed of a substance such as bismuth germanium oxide (BGO) or thallium-doped sodium iodide (NaI(Tl)) has been used. γ-ray injected to this detector is once converted to very weak light using the scintillator, and this very weak light is converted to electric signals using a photoelectron multiplier or a photodiode or the like. Therefore, there has been a problem of leading to large sizing of the nuclear medicine imaging device.
Consequently, at present, semiconductor detectors composed of a semiconductor cell such as cadmium telluride (CdTe) or cadmium zinc telluride (CdZnTe) have been watched. These semiconductor detectors convert γ-ray directly to charge carriers (electrons and positive holes). Therefore, because γ-ray can be detected by each semiconductor cell, compact-sizing and weight-reduction of a device can be expected as compared with the case using the scintillator and the photoelectron multiplier. In addition, number of charge carriers to be generated is far more as compared with number obtained by the scintillator detector, which means that good energy resolution can be obtained. It should be noted that, energy resolution means capability of detecting energy value of γ-ray in good precision. For example, it means capability of detecting γ-ray of 511 keV, as an energy of 511 keV correctly.
By the way, in order to obtain a highly precise image in the PET device, which is a kind of the nuclear medicine diagnosis device, there is a demand to enhance a spatial resolution. In addition, in the PET device, there is a demand to enhance γ-ray detection sensitivity, for example, to increase arrangement density of radiation detectors to shorten examination time. It should be noted that, detection sensitivity means capability of detecting many γ-ray in a predetermined energy window.
These demands are present also in the nuclear medicine diagnosis device other than the SPECT device and the γ-ray camera. As a detector array means therefor, as shown in FIG. 5 of JP-A-2007-78369, the detection module composed of a structure, where a semiconductor radiation detection element is stacked in multiple pieces via a metal plate, is arranged, so that a stacked plane becomes vertical to the wiring board.
As described above, features of the semiconductor detector is good energy resolution, and good energy resolution leads to advantage of high-definition and high quantitative property in image diagnosis. And, this advantage becomes far more conspicuous with enhancement of spatial resolution and detection sensitivity. It should be noted that spatial resolution means capability of precisely detecting emission position of γ-ray.
On the other hand, the semiconductor element represented by CdTe is generally sensitive to mechanical impact or defect, and for convenience of protection thereof, it is necessary to protect and support a surface with a metal plate as shown in FIG. 5 of JP-A-2007-78369, or the like, and is attached to a substrate after fixing a metal plate onto the semiconductor element.
In addition, in the case of mounting extremely large number of detectors onto the wiring board, as in the PET device, it is desirable to be handled in an automatic mounting device in view of cost reduction. In this case, however, in consideration of mounting position error of a device, it is necessary to provide a certain clearance, so that each of the detection modules does not come into contact with.
Presence of such a metal plate or clearance could incur dead space in γ-ray detection, that is, decrease in detection sensitivity and spatial resolution. Therefore, it has been desired a detection element, a module and a detector array substrate which can minimize such problems.
In view of the above circumstances, it is an object of the present invention to provide a detector array substrate which is capable of enhancing detection sensitivity and spatial resolution, and a nuclear medicine diagnosis device using the same.
The detector array substrate of a first present invention is a detector array substrate arranged with detection elements for detecting a radiation by converting to electric signals, in an XYZ space formed by a Z direction, which is the same direction as a body axis of a subject, a Y direction, which is nearly the same direction as an incident direction of radiation from a radioactive material in the subject, and an X direction, which is vertical to a ZY plane formed by the Z direction and the Y direction, which provides a flat detection module stacked in plural thr detection elements, which is connected to the detectors each other, and have signal electrodes for reading out signals of the respective detectors and bias electrodes for applying bias voltage to the respective detectors, in order to form plural detectors for detecting the radiation; stacks the detectors by arranging the detection modules having the plural detectors in the X direction, as well as by arranging the detection modules in a flat structure on both planes or one plane of the wiring board in the Z direction, as for the XZ plane for detecting the radiation; and provides the plural detection modules in the Y direction.
The nuclear medicine diagnosis device of a second present invention is provided with a detector array structure where the detector array substrate of the first present invention is arranged in multiple in a Z direction.
According to the present invention, a detector array substrate which is capable of enhancing detection sensitivity and spatial resolution, and a nuclear medicine diagnosis device using the same can be realized.
Other objects, features and advantages of the present invention will become apparent from the following description of the examples of the invention relating to the accompanying drawings.
Explanation will be given next in detail on best embodiments for carrying out the present invention, with reference to accompanied drawings.
The PET device 1 of the nuclear medicine diagnosis device, which is one embodiment of the present invention, is configured by provided with, as shown in
In the present description, the I/O operation device 15 having the display device 14 or the like is arranged outside of an examination room (not shown), where at least the gantry 11, the bed 13 or the like is arranged, so as to avoid a laboratory technician operating the I/O operation device 15 being exposed to radiation.
As shown in
In the present description, by taking a configuration where the detector array substrates 30 oppose each other around the subject P as nearly the center, data analysis relating to position of the accumulation part C of the positron emission nuclide becomes easy. It should be noted that, the detector array substrates 30 may also be configured without opposing each other.
In the present description, an X direction, a Y direction and a Z direction, shown in
A Z direction, shown in
And, the detector array substrates 30 having the detection modules 40 are arranged in a Z direction (direction vertical to the paper plane of
In the present description, because the detector array substrates 30 are shown in planar figure in
Because electric signals corresponding to quantity or energy of radiation can be detected, when voltage is applied to the CdTe semiconductor, configuring this detection module 40, the single crystal of the CdTe semiconductor of the detection module 40 absorbs γ-ray in good efficiency and directly converts them to electric signals, and thus provides high detection sensitivity and good energy resolution of γ-ray.
The signal processing unit 31 of the detection module 40 to be mounted on the detector array substrates 30 shown in
It should be noted that, in
As shown in
As shown in
In the present description, in
As shown in
In the detection element 50 configuring the detection module 40, as shown in
In examination time of the subject P by the PET device 1 shown in
In configuring the detection module 40 using the detection element 50, as shown in
And, as shown in
As shown in
In examination time by the PET device 1 shown in
And, detection signals by γ-ray injected to the detection element 50 are read out via each of the copper ribbon-like or wire-like conductors 54a, 54b, 54c, 54d and each of the signal electrodes 52a, 52b, 52c, 52d of the detection module 40.
In this way, one detection module 40 with a length of Lx=10 mm, Ly=10 mm and Lz=2 mm shown in
In the present description, by shortening the length of an X direction of the detector to ¼ Lx=2.5 mm, spatial resolution in an X direction during examination, shown in
The detection module 40 (refer to
As understood from
<<The Wiring Board 32 Mounted with the Detection Modules 40>>
As shown in
Each conductor 54 for the signal electrode 52 to be connected to each of the signal electrodes 52 (52a, 52b, 52c, 52d) (refer to
In addition, as for the bias electrodes 53 to contact directly with the wiring board 32 of the detection modules 40, it is face-bonded directly to the wiring board 32 using conductive adhesives without using a conductor, and is connected to a wiring (not drawing) for the bias electrode formed onto the wiring board 32.
The conductor 55 for the bias electrodes 53 at the upper part of each detection module 40 extends in a Y direction (the left and right direction in the paper plane of
As understood from
In this way, for example, in
Therefore, because the detection channel has four copper ribbon-like or wire conductors 54a, 54b, 54c and 54d per one detection module 40, and has four channels, it is a structure that the detection module 40 contains at least 129 wirings, which is composed of 32 pieces×4 channels=128 channels, that is, 128 pieces of wirings for reading out signals, and one piece of wiring for applying bias voltage (32h or the like), in the wiring board 32. It should be noted that, because the wiring for applying bias voltage applies reversed bias voltage with the same potential, the wiring for applying bias voltage is enough to be one piece.
In the present description, in mounting the detection module 40 in a Y direction (refer to
The reason is that because the conductors 54 for the signal electrode has a potential of nearly 0 volt, and the conductors 55 for the bias electrode has a potential of several hundred volt, placing them in facing position eliminates risk of breakdown caused by high voltage, which thus provides easier narrowing of space between the detection modules 40 of a Y direction of a direction, where γ-ray injects mainly, and thus density of the CdTe semiconductor enhances, resulting in enhancement of detection sensitivity of γ-ray.
It should be noted that, supply of reversed bias voltage to the bias electrodes 53 of the detection module 40 naturally allows exchange of positions for an anode and a cathode of the detection element 50.
In addition, in the present embodiment, the case, where the two detection elements 50 (refer to
Explanation will be given next on a variant embodiment, with reference to
It should be noted that,
The detector array substrate 30′ of the variant embodiment shown in
The detector array substrate 30′ of the variant embodiment uses a detection modules 40′ laminated with detection elements 50a′ and 50b′ having different length of a Y direction (the left and right direction in the paper plane of
Because a configuration other than this is similar to the embodiment, a configuration element similar to the embodiment is shown by attaching ‘(dash) to a code of the embodiment, and detailed explanation is omitted.
According to this configuration, in lamination of the detection elements 50a’ and 50b′, because of absence of the conductors 54′ between the detection elements 50a′ and 50b′, thickness can be eliminated by an amount of the conductors 54′ in the detection modules 40′, resulting in enhancement of density of the CdTe semiconductor of a Z direction (refer to
In addition, because a conductor 54′ is pulled out from the signal electrode 52′ exposed outward of a place where the detection element 50a′ having longer length is protruded from the detection element 50b′ having shorter length, in the detection module 40′, the conductors 54′ can be wired easily.
In disposing the detectors of the embodiment, as shown in
And, as shown in
Further, as for a Y direction, connection of the signal electrode 52 (52a, 52b, 52c, 52d) and the bias electrodes 53 from each of the detection modules 40, is connected to the wiring board 32, at a position of a Y direction side relative to each of the detection modules 40. In this case, as a member for connecting the signal electrode 52 and the bias electrodes 53 of the detection modules 40, and the wiring board 32, a wire-like or ribbon-like conductor is used.
The nuclear medicine diagnosis device is configured by arranging the detector array substrate 30 composed of the above, in multiple in a Z direction, and by arranging the detector array substrate 30 in a circular pattern at the circumference of the subject P, so that the Z direction becomes a body axis direction.
According to the embodiments of the present invention, the following effects are obtained:
(1) As shown in
(2) By using the detection element 50 patterned by the signal electrode 52, detection pitch in an X direction can be adjusted freely, by adjusting width s of the signal electrode 52 shown in
(3) By mounting the plane 32a, where the wiring board 32 extends, and each signal electrode 52 and 53 of the detection element 50, onto the wiring board 32, so that they are in parallel, adhesive area of the wiring board 32 and the detection element 50, that is holding area can be maintained more, which increases supporting strength and enhances mechanical reliability.
Therefore, stable detection of γ-ray becomes possible. That is, generation of failures is suppressed and stable operation of the device is realized.
(4) As shown in
(5) As shown in
(6) By using a wire-like or ribbon-like conductor as the conductors 54, 55 of a connection member, scattering between the incident γ-ray and the conductors 54, 55, that is, decrease in detection efficiency can be minimized, and detection sensitivity relative to a Z direction can be enhanced, as well as occupation ratio of the detection element 50 in a Z direction increases and spatial resolution relative to a Z direction can be enhanced.
(7) Because a conventional metal plate was made unnecessary, density of the CdTe semiconductor of the detector array substrate 30 having the detection module 40 is enhanced, and γ-ray can be detected efficiently relative to a Y direction, where γ-ray injects mainly. Therefore, it is possible to enhance detection sensitivity of γ-ray, as well as enhance spatial resolution at the same time.
Accordingly, in the PET device 1, it is possible to provide a highly fine and highly quantitative image.
(8) Because a conventional metal plate was made unnecessary, material cost is solved, as well as production becomes easy due to elimination of the attaching step of the metal plate.
It should be noted that, in the present embodiment, the case, where the detection module 40 was fixedly set up at both of the planes 32a of the wiring board 32, was exemplified, however, the detection module 40 may be fixedly set up at one plane 32a of the wiring board 32.
In addition, the case, where the two detector array substrates 30 were arranged in a Z direction of the body axis direction of the subject P, was exemplified, however, it is possible to arrange arbitrary number of the detector array substrates 30.
In addition, each length and number exemplified in the present embodiment are only one example, and they should not be limited to these numerical values.
It is apparent to those skilled in the art that, although the above description has been made on examples, the present invention should not be limited thereto, and various changes and modifications can be made within the spirit of the present invention and the scope of the appended claims.
Number | Date | Country | Kind |
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2008-040853 | Feb 2008 | JP | national |
Number | Date | Country | |
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Parent | PCT/JP2009/052626 | Feb 2009 | US |
Child | 12857950 | US |