Iwakami et al., Chem. Pharm. Bull. 34(9), pp. 3960-3963, 1986. |
Chem. abstr. vol. 106, No. 12, p. 363, col. 2, abstract No. 90177x, 1987. |
Schabitz, WR, et al., "The Effects of prolonged treatement with . . . ", J. Neurol. Sci. 138:1-2:21-25 (1996). |
D'Orlando KJ, et al., "Citicoline (CDP-Choline); Mechanisms of . . . " Neurol. Res., 17:4:281-284 (1995). |
Nishio K., et al., "Novel Water-Soluble Derivatives . . . ", Proc. Soc. Exp. Biol. Med., 203:2:200-208 (1993). |
Jacob, J.N. et al., "Gamma-aminobutyric acid esters. 3. Synthesis, brain uptake, and pharmacological properties of C-18 Glyceryl lipid esters of GABA with varying degree of unsaturation," J. Med. Chem. 30:1573-6 (1987). |
Hesse, G.W. et al., "Uptake in brain and neurophysiological activity of two lipid esters of gamma-aminobutyric acid," Neuropharmacol. 27:637-40 (1988). |
Jacob, J.N. et al., "Synthesis, brain uptake and pharmacological properties of a glyceryl lipid containing GABA and the GABA-T inhibitor, gamma-vinyl-GABA," J. Med. Chem. 33:733-6 (1990). |
Ferrari et al., 9-cis-6,6'-diapo-.gamma., .gamma.-carotenedioic acid derivatives and pharmaceutical compositions containing them, p. 710 Abstract No. 20423w, Chemical Abstracts 95(23) issued Dec. 7, 1981, EP30,009 dated Jun. 10, 1981. |
T. Higuchi et al., "Prodrugs as Novel Drug Delivery Systems", American Chem. Society, ACS Symposium Series, vol. 14, pp. 14-15 (1975). |
S. Iwakami et al., "Inhibition of Arachidonate 5-Lipoxygenase by Phenolic Compounds", Chem. Pharm. Bull. (Japan), 34(9), 3960-3963,1986. |
Y. Makino et al., Chemical Abstracts, vol. 106, No. 12, issued 23 Mar. 1987, "Pharmaceuticals Permeable to Blood-Brain Barrier", p. 363, Abstract No. 90177x, Japan Kokai Tokyo Koho, JP61,204,136, dated Sep. 10, 1986. |
G. Dhopeshwarker, Chemical Abstracts, vol. 76, No. 16, issued Apr. 17, 1972, "Fatty Acid Transport Into the Brain", p. 276, Abstract No. 97365c, Biochim Biophys. Acta 1972, 255(2) 572-9. |
R. Spector, Chemical Abstracts, vol. 108, No. 11, issued Mar. 14, 1988, "Fatty Acid Transport Through the Blood-Brain Barrier", p. 435, Abstract No. 92100q, J. Neurochem. 1988, 50(2), 639-43. |
I. Yamatsu et al., Chemical Abstracts, vol. 100, No. 19, issued May 7, 1984, "Polyprenyl Carboxylic Acid Amides", p. 555, Abstract No. 156839z, EP91,694 dated Oct. 19, 1983. |
V.E. Shashoua, et al., ".gamma.-Aminobutyric Acid Esters.1. Synthesis . . . ", Journal of Medicinal Chemistry, vol. 27, No. 5, pp. 659-664 (1984). |
J.N. Jacob, et al., ".gamma.-Aminobutyric Acid Esters.2.Synthesis Brain Uptake . . . ", J. of Medicinal Chemistry, vol.28, No.1, pp. 106-110 (1985). |
G.W. Hesse et al., "Inhibitory Effect of Cholesteryl.gamma.-Aminobutyrate" Neurolpharmacology, vol. 24, No. 2, pp. 139-146 (1985). |
G. Bourat et al., "Long Chain Esters of Pipotiazine as Long-Acting Psychotropic Pro-Drugs", pp. 105-114, (1976) Med. Chem. Proc. Int. Symp. 5th. |
K.A. Jacobson et al., "Adenosine analogs with covalently attached lipids . . . ", FEBS Letters, vol.225, Nos.1,2 pp. 97-102 (Dec. 1987). |
A. Garzon-Aburbeh et al., "A Lymphotropic Prodrug of L-Dopa:Synthesis" J. Med. Chem. 29: 687-691 (1986). |
U.K. Mazumdar & D.C. Dey, "Preparation and Evaluation of Ethambutol Derivatives", Indian J. Pharm. Sci. 47(6): 179-180 (1984). |
L.M. Gunne et al., "Oral Dyskinesia in Rats Following Brain Lesions and Neuroleptic Drug Administration", Psychopharmacology 77:134-9 1982. |
R.J. Baldessarini et al., "Dopamine and the Pathophysiology of Dyskinesis . . . ", Ann. Rev. Neurosci. 3: 23-41 (1980). |
J.P. Lohr et al., "Neuroleptic-Induced Movement Disorders . . . ", Psychiatry, vol. 3, (1989). |
Jacob, J.N. et al., "Gamma-aminobutyric acid esters. 3. Synthesis, brain uptake, and pharmacological properties of C-18 Glyceryl lipid esters of GABA with varying degree of unsaturation," J. Med. Chem. 30:1573-6 (1987). |
Hesse, G.W. et al., "Uptake in brain and neurophysiological activity of two lipid esters of gamma-aminobutyric acid," Neuropharmacol. 27:637-40 (1988). |
Jacob, J.N. et al., "Synthesis, brain uptake and pharmacological properties of a glyceryl lipid containing GABA and the GABA-T inhibitor, gamma-vinyl-GABA," J. Med. Chem. 33:733-6 (1990). |
T. Higuchi, et al., ACS Symposium Series, vol. 14, see pp. 14 and 15. |
S. Iwakami, et al., Chem. Pharm. Bull. (Japan), 34(9), 3960-3963 (Sep., 1986). |
Y. Makino, et al., Abstract No. 90177x, vol. 106, Sep. 10, 1986. |
G. Dhopeshwarkar, et al., Abstract No. 97365c, vol. 76, Apr. 17, 1972. |
R. Spector, Abstract No. 92100g, vol. 108, Mar. 14, 1988. |
Yamatsu, et al., Abstract No. 156839z, vol. 100, May 7, 1984. |
V.E Shashoua, et al. Journal of Medicinal Chemistry, vol. 27, No. 5 pp. 659-664 (1984). |
J.N. Jacob, et al., Journal of Medicinal Chemistry, vol. 28, No. 1, pp. 106-110 (1985). |
G.W. Hesse, et al., Neurolpharmacology, vol. 24, No. 2, pp. 139-146 (1985). |
G. Bourat and D. Heusse, "Long Chain Esters of Pipotiazine as Long-Acting Psychotropic Pro-Drugs", Med. Chem. Pro. Intl. Symp. 5th (1976), pp. 105-114. |
K.A. Jacobson et al., "Adenosine analogs with covalently attached lipids . . . ", FEBS Letters, vol.225, Nos.1, 2 pp. 97-102 (Dec.1987). |
A. Garzon-Aburheh et al., "A Lymphotropic Prodrug of L-Dopa: Synthesis Pharmacological . . . ", J.Med.Chem. 29: 687-691 (1986). |
U.K. Mazumdar et al., "Preparation and Evaluation of Ethambutol Derivatives", Indian J. Pharm. Sci. 47(6): 179-180 (1985). |
L.M. Gunne et al., "Oral Dyskinesia in Rats Following Brain Lesions . . . ", Psychopharmacology 77: 134-139 (1982). |
R.J. Baldessarini et al., "Dopamine and the Pathophysiology of Dyskinesias . . . ", Ann. Rev. Neurosci. 3: 23-41 (1980). |
J.P. Lohr et al., "Neuroleptic-Induced Movement Disorders: Tarvide Dyskinesia and Other Tarvide Syndromes", Psychiatry, vol.3, 1989. |
Bauret et al, Med. Chem. Proc. Int. Symp., pp. 105-114, 1976. |
Iwakami et al, Chem. Pharm. Bull. (Japan), 34(a),3960-3963, 1980. |