Claims
- 1. In a catheter of the type comprising a catheter body and an inflatable balloon positioned along the length of the catheter body; the improvement comprising:
- a sheath over the balloon, the sheath having a longitudinal line of weakness sufficient to cause the sheath to burst at the line of weakness as the balloon is inflated; and
- a viscous matrix material intermediate between the balloon and the sheath, said viscous matrix material having a drug or combination of drugs for treatment or diagnostics within a body lumen such that when the balloon is inflated it causes the sheath to burst at the line of weakness and expose the viscous matrix material.
- 2. The catheter of claim 1 wherein said viscous matrix also includes drug-containing microcapsules.
- 3. The catheter of claim 1 wherein said viscous matrix has anti-restenosis drugs therein.
- 4. The catheter of claim 1 wherein said viscous matrix comprises a bioabsorbable polymer selected from the group consisting of polyorthoester, polysaccharide, polyphosphoester, polyglycolic acid, polylactic acid and polyvinyl pyrrolidone.
- 5. The catheter of claim 1 wherein said viscous matrix material is sealed within the sheath.
- 6. The catheter of claim 5 wherein the sheath is sealed at its proximal and distal ends to the catheter.
- 7. The catheter of claim 1 wherein the sheath is made from an elastomeric material.
- 8. The catheter of claim 7 wherein the elastomeric material is a silicone elastomer.
- 9. A method for applying a drug to a body lumen comprising the steps of:
- a. inserting a dilatation catheter having a drug-containing viscous matrix material on the exterior of a catheter balloon and a sheath having a longitudinal line of weakness over the balloon and viscous matrix material into a body lumen to a point where treatment is desired;
- b. bursting the sheath at the line of weakness by expanding said balloon, thereby exposing the viscous matrix material;
- c. releasing the exposed viscous matrix material against the lumen wall; and
- d. removing said dilatation catheter.
Parent Case Info
This application is a continuation-in-part of U.S. Ser. No. 07/853,661 filed Mar. 19, 1992 pending which is a continuation-in-part of U.S. Ser. No. 07/637,436 filed Jan. 4, 1991, now U.S. Pat. No. 5,102,402 .
US Referenced Citations (32)
Foreign Referenced Citations (2)
Number |
Date |
Country |
54-35036 |
Oct 1979 |
JPX |
8912478 |
Jun 1988 |
WOX |
Non-Patent Literature Citations (1)
Entry |
"Direct Intraarterial Wall Injection of Microparticles via a Catheter: A Potential Drug Delivery Strategy Following Angioplasty" by Wilensky et al. in Progress in Cardiology, Oct. 1991. |
Continuation in Parts (2)
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Number |
Date |
Country |
Parent |
853661 |
Mar 1992 |
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Parent |
637436 |
Jan 1991 |
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