The present invention relates generally to blood reservoirs for oxygenators used in blood perfusion systems.
Blood perfusion involves encouraging blood through the vessels of the body. For such purposes, blood perfusion systems typically include the use of one or more pumps in an extracorporeal circuit that is interconnected with the vascular system of a patient. Many surgical procedures require or prefer temporary cessation of the heart to create a still operating field. Such procedures may thus rely upon a cardiopulmonary bypass (CPB) perfusion system that temporarily replaces the function of the heart and lungs. Examples of such procedures include the surgical correction of vascular stenosis, valvular disorders, and congenital heart defects. In perfusion systems used for cardiopulmonary bypass surgery, an extracorporeal blood circuit is established that includes at least one pump and an oxygenation device to replace the functions of the heart and lungs, respectively.
More specifically, in cardiopulmonary bypass procedures, oxygen-poor blood (i.e., venous blood) is gravity-drained or vacuum-suctioned from a large vein entering the heart or another major vein in the body (e.g., femoral) and is transferred through a venous line in the extracorporeal circuit. The venous blood is pumped to an oxygenator that provides for oxygen transfer to the blood. Oxygen may be introduced into the blood by, for example, transfer across a membrane. Concurrently, carbon dioxide is removed across the membrane. The oxygenated blood is filtered and then returned through an arterial line to the aorta, femoral, or other artery.
In many cases, an extracorporeal blood circuit includes a blood reservoir that can be used to collect, filter and de-aerate blood from a variety of different sources. For example, a blood reservoir may receive one or more of venous blood from a large vein, vent blood that is collected within the heart and cardiotomy or suction blood that is collected from outside the heart but within the surgical field.
The present invention relates to a blood reservoir that may be used in combination with other elements such as a heart lung machine (HLM), oxygenator, heat exchanger, arterial filter and the like to form an extracorporeal blood circuit. The blood reservoir, as will be described in greater detail herein, may be configured to receive, filter and store blood from a number of sources including vent blood (from within the heart), venous blood (from a major vein), purge blood (from a sampling line) and cardiotomy or suction blood (from within the surgical field). Example 1 is a dual chamber blood reservoir including an activated section and a non-activated section. The non-activated, or clean, section includes an elongate filter and a foamer that is disposed about an upper region of the elongate filter. A purgers funnel extends downwardly through the cylindrical foamer and includes a conical upper portion, a cylindrical lower portion and an intervening central portion. A venous inlet tube extends downwardly through the cylindrical lower portion of the purgers funnel to a position that is proximate a bottom surface of the elongate filter. A vent inlet tube extends downwardly through an aperture formed within the central portion of the purgers funnel to a position that is proximate the bottom surface of the elongate filter.
In Example 2, the dual chamber blood reservoir of Example 1 in which blood that exits the cylindrical lower portion of the purgers funnel is able to slide down the exterior surface of the venous inlet tube.
In Example 3, the dual chamber blood reservoir of Example 1 or 2 in which the central portion of the purgers funnel includes a first aperture that is configured to accommodate the vent inlet tube passing therethrough.
In Example 4, the dual chamber blood reservoir of any of Examples 1, 2 or 3, further including a second vent inlet tube that extends downwardly to a position that is proximate the bottom of the elongate filter.
In Example 5, the dual chamber blood reservoir of Example 4, wherein the central portion of the purgers funnel includes a second aperture that is configured to accommodate the second vent inlet tube, the first and second apertures being radially spaced apart about 180 degrees.
In Example 6, the dual chamber blood reservoir of any of Examples 1 to 5, further including a plurality of purge ports that are in fluid communication with the conical upper portion of the purgers funnel.
In Example 7, the dual chamber blood reservoir of any of Examples 1 to 6 in which the activated section includes a suction blood filter assembly including a cylindrical suction blood filter and a defoamer layer that is disposed about the cylindrical suction blood filter.
In Example 8, the dual chamber blood reservoir of any of Examples 1 to 7, further including a releasable barrier between the activated section and the non-activated section, the releasably barrier configured to be released to permit blood within the activated section to enter the non-activated section in a situation requiring additional blood.
In Example 9, the dual chamber blood reservoir of Example 8, further including a porous media disposed to dissipate velocity in blood flowing from the activated section to the non-activated section.
Example 10 is a dual chamber blood reservoir having a housing and a cover spanning the housing. A first vent port and a second vent port each extend through the cover. A venous port extends through the cover. A purgers port extends through the cover. The blood reservoir includes a purgers funnel that has an upper portion, a lower portion and an intervening central portion. The upper portion is in fluid communication with the purgers port. A first vent tube is in fluid communication with the first vent port and extends externally to the lower portion of the purgers funnel to a position near a lower surface of the housing. A second vent tube is in fluid communication with the second vent port and extends externally to the lower portion of the purgers funnel to a position near the lower surface of the housing. A venous tube is in fluid communication with the venous port and extends within the purgers funnel to a position near the lower surface of the housing.
In Example 11, the dual chamber blood reservoir of Example 10 in which the first vent tube extends downwardly within the upper portion of the purgers funnel and passes to an exterior of the purgers funnel through a first aperture formed in the central portion of the purgers funnel.
In Example 12, the dual chamber blood reservoir of Example 10 or 11 in which the first vent tube extends downwardly within the upper portion of the purgers funnel and passes to an exterior of the purgers funnel through a first aperture formed in the central portion of the purgers funnel.
In Example 13, the dual chamber blood reservoir of any of Examples 10 to 12, further including an elongate filter disposed within the housing such that the vent tubes and the venous tube extend downwardly through the elongate filter.
In Example 14, the dual chamber blood reservoir of Example 13 in which the elongate filter has a lower surface that is disposed near the lower surface of the housing.
In Example 15, the dual chamber blood reservoir of any of Examples 10 to 14, further including a plurality of purgers ports that pass through the cover and that are in fluid communication the upper portion of the purgers funnel.
Example 16 is a blood reservoir having a housing and a filtering assembly disposed within the housing. The housing has a top, a bottom, a venous inlet, a vent inlet and a purgers inlet. The filtering assembly extends from near the top of the housing to near the bottom of the housing. The filtering assembly includes a support structure, a filter membrane disposed about the support structure and a defoamer that is disposed about the filter membrane. The filtering assembly includes a purgers funnel that is in fluid communication with the purgers inlet and that extends downwardly within the filter membrane. The filtering assembly includes a venous tube that is in fluid communication with the venous inlet and that extends through an interior of the purgers funnel to a location near a bottom surface of the filtering assembly. The filtering assembly also includes a vent tube that is in fluid communication with the vent inlet and that extends partially through an interior of the purgers funnel and partially exterior to the purgers funnel to a location near the bottom surface of the filtering assembly.
In Example 17, the blood reservoir of Example 16 in which the venous tube and the vent tube extend downwardly within an interior space of the filter membrane.
In Example 18, the blood reservoir of Example 16 or 17 in which the purgers inlet includes a plurality of purgers ports.
Example 19 is an extracorporeal blood circuit that includes a heart lung machine, an oxygenator, a sampling line downstream of the oxygenator and a blood reservoir. The blood reservoir includes a vent blood inlet, a venous blood inlet and a purgers port configured to accept blood from the sampling line. The blood reservoir is configured to accommodate blood from the sampling line without causing excessive gaseous microembolic activity within the blood from the sampling line.
In Example 20, the extracorporeal blood circuit of Example 19 in which the blood reservoir includes a purgers funnel that is in fluid communication with the purgers port, with the venous blood inlet extending downwardly through an interior of the purgers funnel such that blood from the sampling line is permitted to flow downwardly along an exterior surface of the venous blood inlet.
While multiple embodiments are disclosed, still other embodiments of the present invention will become apparent to those skilled in the art from the following detailed description, which shows and describes illustrative embodiments of the invention. Accordingly, the drawings and detailed description are to be regarded as illustrative in nature and not restrictive.
As shown in
As shown, the non-activated section 26 includes a filtering assembly 48, while the activated section 28 includes a filtering/defoaming assembly 50.
In some embodiments, the housing 30 may include a shield 54 that directs blood from the activated section 28 towards the bottom 46. The shield 54 may be shaped and positioned to minimize turbulence within the blood flow. While relative blood levels may vary during use in the non-activated section 26 and the activated section 28 (when the valve 52 is closed), in some embodiments, the blood level within the non-activated section 26, indicated by a line 56, may be relatively lower than the blood level within the activated section 28, as indicated by a line 58. In some embodiments, the blood level within the non-activated section 26 may instead be higher than the blood level within the activated section 28.
In the activated section 28, the suction filtering/defoaming assembly 50 includes several components. Blood from the suction inlet 44 may pass into a collection funnel 60 and may then slide or otherwise flow down a diverter 62 that is configured to minimize turbulence in the blood flow. The blood then passes through a cylindrical filter 64 and a defoamer 66 that is disposed about the cylindrical filter 64. Blood thus filtered then collects within the activated section 28, where it is stored until it is either needed or subsequently discarded through an exit port 68.
In the non-activated section 26, the filtering assembly 48 includes several components, not all of which are visible in
The filtering assembly 48 also includes a purgers funnel 78 that extends downwardly through the cylindrical defoamer 76 and into the elongate cylindrical filter 70. The purgers funnel 78 is in fluid communication with the purgers inlet 40. The venous inlet tube 74 extends downwardly through the purgers funnel 78. In some embodiments, the venous inlet tube 74 has an outer diameter that is less than an inner diameter of the purgers funnel 78 such that purgers blood collected within the purgers funnel 78 may exit the purgers funnel 78 by sliding down an exterior of the venous inlet tube 74. In some embodiments, this reduces turbulence in the flow of purgers blood, thereby reducing or even eliminating the formation of gaseous microembolic activity in the purgers blood. In some embodiments, the purgers funnel 78 may include fingers (not shown) that form an interference fit with the exterior of the venous inlet tube 74 yet permit blood to flow down the exterior of the venous inlet tube 74. In some embodiments, any entrained air within the blood in the non-activated section 26 may travel up into the cylindrical defoamer 76.
As shown in
In some embodiments, the housing 30 may include a shield 55 that directs blood from the activated section 28 towards the bottom 46. The shield 55 may be shaped and positioned to minimize turbulence within the blood flow. In some embodiments, as illustrated, the shield 55 may include a frame portion 57 and a porous media portion 59. The frame portion 57 supports the porous media portion 59 and helps to anchor the shield 55 within the housing 30. The porous media portion 59 slows blood passing through the shield 55.
While relative blood levels may vary during use in the non-activated section 26 and the activated section 28 (when the barrier 52 is closed), in some embodiments, the blood level within the non-activated section 26, indicated by a line 56, may be relatively lower than the blood level within the activated section 28, as indicated by a line 58. In some embodiments, the blood level within the non-activated section 26 may instead be higher than the blood level within the activated section 28.
In the activated section 28, the suction filtering/defoaming assembly 50 includes several components. Blood from the suction inlet 44 may pass into a collection funnel 60 and may then slide or otherwise flow down a diverter 62 that is configured to minimize turbulence in the blood flow. The blood then passes through a cylindrical filter 64 and a defoamer 66 that is disposed about the cylindrical filter 64. Blood thus filtered then collects within the activated section 28, where it is stored until it is either needed or subsequently discarded through an exit port 68. In some embodiments, blood stored within the activated section 28 may be released into the non-activated section 26 by opening the valve 52.
In the non-activated section 26, the filtering assembly 48 includes several components, not all of which are visible in
The filtering assembly 48 also includes a purgers funnel 78 that extends downwardly through the cylindrical defoamer 76 and into the elongate cylindrical filter 70. The purgers funnel 78 is in fluid communication with the purgers inlet 40. The venous inlet tube 74 extends downwardly through the purgers funnel 78. In some embodiments, the venous inlet tube 74 has an outer diameter that is less than an inner diameter of the purgers funnel 78 such that purgers blood collected within the purgers funnel 78 may exit the purgers funnel 78 by sliding down an exterior of the venous inlet tube 74. In some embodiments, this reduces turbulence in the flow of purgers blood, thereby reducing or even eliminating the formation of gaseous microembolic activity in the purgers blood. In some embodiments, the purgers funnel 78 may include fingers (not shown) that form an interference fit with the exterior of the venous inlet tube 74 yet permit blood to flow down the exterior of the venous inlet tube 74. In some embodiments, any entrained air within the blood in the non-activated section 26 may travel up into the cylindrical defoamer 76.
Various modifications and additions can be made to the exemplary embodiments discussed without departing from the scope of the present invention. For example, while the embodiments described above refer to particular features, the scope of this invention also includes embodiments having different combinations of features and embodiments that do not include all of the above described features.
Number | Date | Country | Kind |
---|---|---|---|
11173655 | Jul 2011 | EP | regional |
This application is a division of U.S. application Ser. No. 13/181,688, filed Jul. 13, 2011, which claims priority to European Patent Application 11173655.9, filed Jul. 12, 2011, of which is hereby incorporated by reference in its entirety.
Number | Name | Date | Kind |
---|---|---|---|
3551072 | Zimmerly | Dec 1970 | A |
3588589 | Emmasingel | Jun 1971 | A |
3588859 | Petree | Jun 1971 | A |
3851181 | Heule | Nov 1974 | A |
3927980 | Leonard | Dec 1975 | A |
4006745 | Sorenson et al. | Feb 1977 | A |
4170765 | Austin et al. | Oct 1979 | A |
4177649 | Venema | Dec 1979 | A |
4193004 | Lobdell et al. | Mar 1980 | A |
4309871 | Venema | Jan 1982 | A |
4374088 | Stenberg et al. | Feb 1983 | A |
4464164 | Troutner et al. | Aug 1984 | A |
4466804 | Hino | Aug 1984 | A |
4490331 | Steg, Jr. | Dec 1984 | A |
4518318 | Jensen et al. | May 1985 | A |
4599093 | Steg, Jr. | Jul 1986 | A |
4602344 | Ferretti et al. | Jul 1986 | A |
4642089 | Zupkas et al. | Feb 1987 | A |
4664682 | Monzen | May 1987 | A |
4678404 | Lorett et al. | Jul 1987 | A |
4701101 | Sapoff | Oct 1987 | A |
4705497 | Shitaokoshi et al. | Nov 1987 | A |
4782451 | Mazzarella et al. | Nov 1988 | A |
4828543 | Weiss et al. | May 1989 | A |
4846800 | Ouriel et al. | Jul 1989 | A |
4876066 | Bringham et al. | Oct 1989 | A |
4955874 | Farrar et al. | Sep 1990 | A |
4984462 | Hass, Jr. et al. | Jan 1991 | A |
4991433 | Warnaka et al. | Feb 1991 | A |
5039430 | Corey, Jr. | Aug 1991 | A |
5039482 | Panzani et al. | Aug 1991 | A |
5043707 | Heinze | Aug 1991 | A |
5049146 | Bringham et al. | Sep 1991 | A |
5055198 | Shettigar | Oct 1991 | A |
5061236 | Sutherland et al. | Oct 1991 | A |
5078677 | Gentelia et al. | Jan 1992 | A |
5110549 | Gordon | May 1992 | A |
5112480 | Hukasawa | May 1992 | A |
5120303 | Hombrouckx | Jun 1992 | A |
5147187 | Ito et al. | Sep 1992 | A |
5158533 | Strauss et al. | Oct 1992 | A |
5178603 | Prince | Jan 1993 | A |
5186431 | Tamarim | Feb 1993 | A |
5215519 | Shettigar | Jun 1993 | A |
5226265 | Kelly | Jul 1993 | A |
5240380 | Mabe | Aug 1993 | A |
5270005 | Raible | Dec 1993 | A |
5282783 | Lindsay | Feb 1994 | A |
5303585 | Lichte | Apr 1994 | A |
5304164 | Lindsay | Apr 1994 | A |
5318510 | Cathcart | Jun 1994 | A |
5399074 | Nose et al. | Mar 1995 | A |
5403273 | Lindsay | Apr 1995 | A |
5411705 | Thor et al. | May 1995 | A |
5458566 | Herrig et al. | Oct 1995 | A |
5458567 | Cathcart | Oct 1995 | A |
5458579 | Chodorow et al. | Oct 1995 | A |
5563490 | Kawaguchi et al. | Oct 1996 | A |
5586085 | Lichte | Dec 1996 | A |
5604315 | Briefer et al. | Feb 1997 | A |
5619993 | Lee | Apr 1997 | A |
5667485 | Lindsay | Sep 1997 | A |
5725357 | Nakazeki et al. | Mar 1998 | A |
5756940 | Van Driel et al. | May 1998 | A |
5770073 | Bach et al. | Jun 1998 | A |
5775879 | Durando | Jul 1998 | A |
5800721 | McBride | Sep 1998 | A |
5823045 | Van Driel et al. | Oct 1998 | A |
5826576 | West | Oct 1998 | A |
5849186 | Raneri | Dec 1998 | A |
5928180 | Krivitski et al. | Jul 1999 | A |
5955672 | Van Driel et al. | Sep 1999 | A |
6017493 | Cambron et al. | Jan 2000 | A |
6048363 | Nagyszalanczy et al. | Apr 2000 | A |
6123519 | Kato et al. | Sep 2000 | A |
6164325 | Braun | Dec 2000 | A |
6287270 | Fini | Sep 2001 | B1 |
6337049 | Tamari | Jan 2002 | B1 |
6345214 | Dulphy-Vigor et al. | Feb 2002 | B1 |
6475176 | Fini | Nov 2002 | B2 |
6542848 | Neeser et al. | Apr 2003 | B1 |
6564627 | Sabini et al. | May 2003 | B1 |
6592340 | Horo et al. | Jul 2003 | B1 |
6631639 | Dam et al. | Oct 2003 | B1 |
6652495 | Walker | Nov 2003 | B1 |
6694570 | Chen | Feb 2004 | B2 |
6770048 | Fini | Aug 2004 | B2 |
6931926 | Van Ee | Aug 2005 | B1 |
7072769 | Fletcher-Haynes et al. | Jul 2006 | B2 |
7147614 | Fini | Dec 2006 | B2 |
7591812 | Tamari | Sep 2009 | B1 |
7694570 | Dam et al. | Apr 2010 | B1 |
8105265 | Demers et al. | Jan 2012 | B2 |
8409124 | Steffens et al. | Apr 2013 | B2 |
8500673 | Zanotti et al. | Aug 2013 | B2 |
8506513 | Rossi et al. | Aug 2013 | B2 |
8734376 | Simpson et al. | May 2014 | B2 |
9011769 | Silvestri et al. | Apr 2015 | B2 |
20010013822 | Nazarian et al. | Aug 2001 | A1 |
20010050256 | Krivitski | Dec 2001 | A1 |
20020032399 | Fini | Mar 2002 | A1 |
20020033181 | Groth et al. | Mar 2002 | A1 |
20020085952 | Ellingboe et al. | Jul 2002 | A1 |
20020094300 | Yokoyama | Jul 2002 | A1 |
20020133066 | Miller et al. | Sep 2002 | A1 |
20030033871 | Carroll et al. | Feb 2003 | A1 |
20030035730 | Schob | Feb 2003 | A1 |
20030045772 | Riech et al. | Mar 2003 | A1 |
20030139643 | Smith et al. | Jul 2003 | A1 |
20030144646 | Se et al. | Jul 2003 | A1 |
20030175151 | Ghelli et al. | Sep 2003 | A1 |
20040047737 | Nose et al. | Mar 2004 | A1 |
20040064292 | Beck et al. | Apr 2004 | A1 |
20040152944 | Medvedev et al. | Aug 2004 | A1 |
20050025630 | Ayre et al. | Feb 2005 | A1 |
20050119600 | Lucke et al. | Jun 2005 | A1 |
20050230313 | O'Mahony et al. | Oct 2005 | A1 |
20060015056 | Ellingboe et al. | Jan 2006 | A1 |
20060089695 | Bolea et al. | Apr 2006 | A1 |
20060092360 | Hong | May 2006 | A1 |
20060150596 | Takahashi et al. | Jul 2006 | A1 |
20060167400 | Ellingboe et al. | Jul 2006 | A1 |
20060226087 | Robinson et al. | Oct 2006 | A1 |
20060260392 | Hedrick | Nov 2006 | A1 |
20060277269 | Dent et al. | Dec 2006 | A1 |
20070017518 | Farrugia et al. | Jan 2007 | A1 |
20070110612 | Ito | May 2007 | A1 |
20070142923 | Ayre et al. | Jun 2007 | A1 |
20070194981 | Hagg et al. | Aug 2007 | A1 |
20070209662 | Bowen et al. | Sep 2007 | A1 |
20080027368 | Kollar et al. | Jan 2008 | A1 |
20080078382 | LeMahieu et al. | Apr 2008 | A1 |
20080171960 | Brieske et al. | Jul 2008 | A1 |
20080245530 | Kuzmichev | Oct 2008 | A1 |
20080275377 | Paolini et al. | Nov 2008 | A1 |
20090012443 | Ghelli | Jan 2009 | A1 |
20090099498 | Demers et al. | Apr 2009 | A1 |
20090149950 | Wampler | Jun 2009 | A1 |
20100042038 | Urdahl et al. | Feb 2010 | A1 |
20100140182 | Chapman et al. | Jun 2010 | A1 |
20100275953 | Orue Orue et al. | Nov 2010 | A1 |
20110098625 | Masala et al. | Apr 2011 | A1 |
20110257576 | Simpson et al. | Oct 2011 | A1 |
20110257578 | Zanotti et al. | Oct 2011 | A1 |
20110257579 | Rossi et al. | Oct 2011 | A1 |
20120067133 | Waldrop et al. | Mar 2012 | A1 |
20120130299 | Knott et al. | May 2012 | A1 |
20130017119 | Silvestri et al. | Jan 2013 | A1 |
20130303965 | Rossi et al. | Nov 2013 | A1 |
20150100253 | Austerlitz et al. | Apr 2015 | A1 |
20170089746 | Rossi | Mar 2017 | A1 |
Number | Date | Country |
---|---|---|
86103696 | Jan 1987 | CN |
1147964 | Apr 1997 | CN |
1197677 | Nov 1998 | CN |
1458851 | Nov 2003 | CN |
2455229 | May 1976 | DE |
2754894 | Jun 1979 | DE |
3935502 | May 1991 | DE |
19840399 | Mar 1999 | DE |
102004040441 | Jun 2006 | DE |
102005001779 | Sep 2006 | DE |
102005029682 | Dec 2006 | DE |
102007026010 | Dec 2008 | DE |
0371173 | Jun 1990 | EP |
0472480 | Feb 1992 | EP |
0587251 | Mar 1994 | EP |
0820775 | Jan 1998 | EP |
0952433 | Oct 1999 | EP |
1053760 | Nov 2000 | EP |
1070509 | Jan 2001 | EP |
0690730 | May 2002 | EP |
1210956 | Jun 2002 | EP |
0766974 | Sep 2006 | EP |
2754458 | Jul 2014 | EP |
2435106 | Nov 2014 | EP |
2842584 | Mar 2015 | EP |
2811752 | Jan 2002 | FR |
2009862 | Jun 1979 | GB |
2109934 | Jun 1983 | GB |
S5623960 | Mar 1981 | JP |
S57500411 | Mar 1982 | JP |
S62258671 | Nov 1987 | JP |
03091352 | Sep 1991 | JP |
H03091352 | Aug 1994 | JP |
819602 | Jan 1996 | JP |
2944749 | Jun 1999 | JP |
H11506701 | Jun 1999 | JP |
H08506982 | Jul 1999 | JP |
2000000299 | Jan 2000 | JP |
2001503665 | Mar 2001 | JP |
2001204815 | Jul 2001 | JP |
2001514939 | Sep 2001 | JP |
2001523339 | Nov 2001 | JP |
2002165878 | Jun 2002 | JP |
2002336348 | Nov 2002 | JP |
2003052717 | Feb 2003 | JP |
2003126246 | May 2003 | JP |
2005066013 | Mar 2005 | JP |
2006025531 | Sep 2006 | JP |
2006325750 | Dec 2006 | JP |
2007130290 | May 2007 | JP |
2008597 | Jan 2008 | JP |
2008194386 | Aug 2008 | JP |
2008270595 | Nov 2008 | JP |
2009240428 | Oct 2009 | JP |
2009287593 | Dec 2009 | JP |
2011076394 | Apr 2011 | JP |
WO1994021311 | Sep 1994 | WO |
WO1996024397 | Aug 1996 | WO |
WO1997033672 | Sep 1997 | WO |
WO1998020957 | May 1998 | WO |
WO1998048868 | Nov 1998 | WO |
WO1999008734 | Feb 1999 | WO |
WO1999065413 | Dec 1999 | WO |
WO2000015154 | Mar 2000 | WO |
WO2000044415 | Aug 2000 | WO |
WO2001047442 | Jul 2001 | WO |
WO2001076656 | Oct 2001 | WO |
WO2002039931 | May 2002 | WO |
WO2002039933 | May 2002 | WO |
WO2002095675 | Nov 2002 | WO |
WO2003026724 | Apr 2003 | WO |
WO2006021295 | Feb 2006 | WO |
WO2006057650 | Jul 2006 | WO |
2006122282 | Nov 2006 | WO |
2007018513 | Feb 2007 | WO |
WO2008119993 | Oct 2008 | WO |
2009144522 | Dec 2009 | WO |
20140041604 | Apr 2010 | WO |
Entry |
---|
International Preliminary Report on Patentability issued in PCT/IB2014/061491 dated Dec. 1, 2016, 12 pages. |
International Search Report and Written Opinion issued in PCT/IB2014/061491, dated Mar. 8, 2015, 16 pages. |
International Preliminary Report on Patentability issued in PCT/EP2010/055444, dated Oct. 5, 2011, 10 pages (with English translation). |
International Search Report and Written Opinion issued in PCT/EP2010/055444, dated Aug. 20, 2010, 10 pages (English Translation of SR). |
Wikipedia, “Fullstandmessung” [online]. Retrieved from https://de.wikipedia.org/w/index.php?title=F%C3%BCIIstandmessung&oldid=69998631, last modifed Jan. 30, 2010. English translation retrieved from https://en.wikipedia.org/wiki/Level_sensor, Oct. 18, 2016. |
Catalog of Products, 2009 Terumo Europe Cardiovascular Systems, 142 pages. |
Definition of “Cylinder”, downloaded from http://dictionary.reference.com/browse/cylinder, download on Apr. 28, 2014, 3 pages. |
European Search Report issued in EP 10160436, dated Nov. 5, 2010, 9 pages. |
European Search Report issued in EP Application No. 03004815, completed Apr. 25, 2003, 3 pages. |
European Search Report issued in EP Application No. 11162020, dated Nov. 7, 2011, 8 pages. |
European Search Report issued in EP Application No. 11173655, completed Nov. 30, 2011, 9 pages. |
European Search Report issued in EP Application No. 12159592, dated Apr. 24, 2012, 6 pages. |
Extended European Search Report issued in 1488440.3, dated Jan. 30, 2015, 7 pages. |
Fischer, Gerhard, Betriebsmesstechnik, unveranderte Auflage, VEB Verlag Technik Berlin, 1986, 3 pages (machine translations: Business measuring technique, unchanged edition). |
Henriksen Kerm et al., “Envisioning Patient Safety in the Year 2025: Eight Perspectives”, Advances in Patient Safety: New Directions and Alternative Approaches, Agency for Healthcare Research and Quality, vol. 1, Aug. 2008. |
International Preliminary Report on Patentability, Chapter II, issued in PCT/EP2010/055522, (with translation) dated May 31, 2011, 13 pages. |
International Search Report and Written Opinion issued in PCT/EP2010/055522, (with translation) dated Aug. 6, 2010, 10 pages. |
International Search Report and Written Opinion issued in PCT/IB2011/051639, dated Nov. 18, 2011, 15 pages. |
International Search Report issued in PCT/IB2012/053497, completed Nov. 15, 2012, 4 pages. |
Klonoff, David C., “Designing an Artificial Pancreas System to be Compatible with Other Medical Devices”, Journal of Diabetes Science and Technology, vol. 2, No. 5, Sep. 2008, pp. 741-745. |
Terumo Europe Cardiovascular Systems, Innovative Products for the Treatment of Cardiovascular Disease, 2006 Terumo Europe, 105 pages. |
Van der Togt, Remko et al., “Electromagnetic Interference From Radio Frequency Identification Inducing Potentially Hazardous Incidents in Critical Care medical Equipment”, JAMA, Jun. 25, 2008, vol. 299, No. 24, 7 pages. |
Weber, Tim, “Talking Barcodes that Change our Lives”, BBC News published April 48, 2004, 3 pages. |
Number | Date | Country | |
---|---|---|---|
20150196703 A1 | Jul 2015 | US |
Number | Date | Country | |
---|---|---|---|
Parent | 13181688 | Jul 2011 | US |
Child | 14668933 | US |