1. Field of the Invention
The present invention relates generally to lasers and, more particularly, to output optical energy distributions of lasers.
2. Description of Related Art
A variety of laser systems are present in the prior art. A solid-state laser system generally comprises a laser rod for emitting coherent light and a stimulation source for stimulating the laser rod to emit the coherent light. Flashlamps are typically used as stimulation sources for Erbium laser systems, for example. The flashlamp is driven by a flashlamp current, which comprises a predetermined pulse shape and a predetermined frequency.
The flashlamp current drives the flashlamp at the predetermined frequency, to thereby produce an output flashlamp light distribution having substantially the same frequency as the flashlamp current. This output flashlamp light distribution from the flashlamp drives the laser rod to produce coherent light at substantially the same predetermined frequency as the flashlamp current. The coherent light generated by the laser rod has an output optical energy distribution over time that generally corresponds to the pulse shape of the flashlamp current.
The pulse shape of the output optical energy distribution over time typically comprises a relatively gradually rising energy that ramps up to a maximum energy, and a subsequent decreasing energy over time. The pulse shape of a typical output optical energy distribution can provide a relatively efficient operation of the laser system, which corresponds to a relatively high ratio of average output optical energy to average power inputted into the laser system.
The prior art pulse shape and frequency may be suitable for thermal cutting procedures, for example, where the output optical energy is directed onto a target surface to induce cutting. New cutting procedures, however, do not altogether rely on laser-induced thermal cutting mechanisms. More particularly, a new cutting mechanism directs output optical energy from a laser system into a distribution of atomized fluid particles located in a volume of space just above the target surface. The output optical energy interacts with the atomized fluid particles causing the atomized fluid particles to expand and impart electromagnetically-induced mechanical cutting forces onto the target surface. As a result of the unique interactions of the output optical energy with the atomized fluid particles, typical prior art output optical energy distribution pulse shapes and frequencies have not been especially suited for providing optical electromagnetically-induced mechanical cutting. Specialized output optical energy distributions are required for optimal cutting when the output optical energy is directed into a distribution of atomized fluid particles for effectuating electromagnetically-induced mechanical cutting of the target surface.
The output optical energy distributions of the present invention comprise relatively high energy magnitudes at the beginning of each pulse. As a result of these relatively high energy magnitudes at the beginning of each pulse, the leading edge of each pulse comprises a relatively large slope. This slope is preferably greater than or equal to 5. Additionally, the full-width half-max (FWHM) values of the output optical energy distributions are greater than 0.025 microseconds. More preferably, the full-width half-max values are between 0.025 and 250 microseconds and, more preferably, are between 10 and 150 microseconds. The full-width half-max value is about 70 microseconds in the illustrated embodiment. A flashlamp is used to drive the laser system, and a current is used to drive the flashlamp. A flashlamp current generating circuit comprises a solid core inductor having an inductance of about 50 microhenries and a capacitor having a capacitance of about 50 microfarads.
The present invention, together with additional features and advantages thereof, may best be understood by reference to the following description taken in connection with the accompanying illustrative drawings.
Referring more particularly to the drawings,
The flashlamp 41 is close-coupled to laser rod (not shown), which preferably comprises a cylindrical crystal. The flashlamp 41 and the laser rod are positioned parallel to one another with preferably less than 1 centimeter distance therebetween. The laser rod is suspended on two plates, and is not electrically connected to the flashlamp-driving current circuit 30. Although the flashlamp 41 comprises the preferred means of stimulating the laser rod, other means are also contemplated by the present invention. Diodes, for example, may be used instead of flashlamps for the excitation source. The use of diodes for generating light amplification by stimulated emission is discussed in the book Solid-State Laser Engineering, Fourth Extensively Revised and Updated Edition, by Walter Koechner, published in 1996, the contents of which are expressly incorporated herein by reference.
The incoherent light from the presently preferred flashlamp 41 impinges on the outer surface of the laser rod. As the incoherent light penetrates into the laser rod, impurities within the laser rod absorb the penetrating light and subsequently emit coherent light. The impurities may comprise erbium and chromium, and the laser rod itself may comprise a crystal such as YSGG, for example. The presently preferred laser system comprises either an Er, Cr:YSGG solid state laser, which generates electromagnetic energy having a wavelength in a range of 2.70 to 2.80 microns, or an erbium, yttrium, aluminum garnet (Er:YAG) solid state laser, which generates electromagnetic energy having a wavelength of 2.94 microns. As presently preferred, the Er, Cr:YSGG solid state laser has a wavelength of approximately 2.78 microns and the Er:YAG solid state laser has a wavelength of approximately 2.94 microns. According to one alternative embodiment, the laser rod may comprises a YAG crystal, and the impurities may comprise erbium impurities. A variety of other possibilities exist, a few of which are set forth in the above-mentioned book Solid-State Laser Engineering, Fourth Extensively Revised and Updated Edition, by Walter Koechner, published in 1996, the contents of which are expressly incorporated herein by reference. Other possible laser systems include an erbium, yttrium, scandium, gallium garnet (Er:YSGG) solid state laser, which generates electromagnetic energy having a wavelength in a range of 2.70 to 2.80 microns; an erbium, yttrium, aluminum garnet (Er:YAG) solid state laser, which generates electromagnetic energy having a wavelength of 2.94 microns; chromium, thulium, erbium, yttrium, aluminum garnet (CTE:YAG) solid state laser, which generates electromagnetic energy having a wavelength of 2.69 microns; erbium, yttrium orthoaluminate (Er:YAL03) solid state laser, which generates electromagnetic energy having a wavelength in a range of 2.71 to 2.86 microns; holmium, yttrium, aluminum garnet (Ho:YAG) solid state laser, which generates electromagnetic energy having a wavelength of 2.10 microns; quadrupled neodymium, yttrium, aluminum garnet (quadrupled Nd:YAG) solid state laser, which generates electromagnetic energy having a wavelength of 266 nanometers; argon fluoride (ArF) excimer laser, which generates electromagnetic energy having a wavelength of 193 nanometers; xenon chloride (XeCl) excimer laser, which generates electromagnetic energy having a wavelength of 308 nanometers; krypton fluoride (KrF) excimer laser, which generates electromagnetic energy having a wavelength of 248 nanometers; and carbon dioxide (C02), which generates electromagnetic energy having a wavelength in a range of 9 to 11 microns.
Particles, such as electrons, associated with the impurities absorb energy from the impinging incoherent radiation and rise to higher valence states. The particles that rise to metastable levels remain at this level for periods of time until, for example, energy particles of the radiation excite stimulated transitions. The stimulation of a particle in the metastable level by an energy particle results in both of the particles decaying to a ground state and an emission of twin coherent photons (particles of energy). The twin coherent photons can resonate through the laser rod between mirrors at opposing ends of the laser rod, and can stimulate other particles on the metastable level, to thereby generate subsequent twin coherent photon emissions. This process is referred to as light amplification by stimulated emission. With this process, a twin pair of coherent photons will contact two particles on the metastable level, to thereby yield four coherent photons. Subsequently, the four coherent photons will collide with other particles on the metastable level to thereby yield eight coherent photons.
The amplification effect will continue until a majority of particles, which were raised to the metastable level by the stimulating incoherent light from the flashlamp 41, have decayed back to the ground state. The decay of a majority of particles from the metastable state to the ground state results in the generation of a large number of photons, corresponding to an upwardly rising micropulse (64, for example,
The output optical energy distribution over time of the laser system is illustrated in
According to the present invention, the output optical energy distribution 60 comprises a large magnitude. This large magnitude corresponds to one or more sharply-rising micropulses at the leading edge of the pulse. As illustrated in
As mentioned above, the full-width half-max range is defined from a beginning time, where the amplitude first rises above one-half the peak amplitude, to an ending time, where the amplitude falls below one-half the peak amplitude a final time during the pulse width. The full-width half-max value is defined as the difference between the beginning time and the ending time.
The location of the full-width half-max range along the time axis, relative to the pulse width, is closer to the beginning of the pulse than the end of the pulse. The location of the full-width half-max range is preferably within the first half of the pulse and, more preferably, is within about the first third of the pulse along the time axis. Other locations of the full-width half-max range are also possible in accordance with the present invention. The beginning time preferably occurs within the first 10 to 15 microseconds and, more preferably, occurs within the first 12.5 microseconds from the leading edge of the pulse. The beginning time, however, may occur either earlier or later within the pulse. The beginning time is preferably achieved within the first tenth of the pulse width.
Another distinguishing feature of the output optical energy distribution 70 is that the micropulses 64, 66, 68, for example, comprise approximately one-third of the maximum amplitude 62. More preferably, the leading micropulses 64, 66, 68 comprise an amplitude of approximately one-half of the maximum amplitude 62. In contrast, the leading micropulses of the prior art, as shown in
The slope of the output optical energy distribution 60 is greater than or equal to 5 and, more preferably, is greater than about 10. In the illustrated embodiment, the slope is about 50. In contrast, the slope of the output optical energy distribution 20 of the prior art is about 4.
The output optical energy distribution 60 of the present invention is useful for maximizing a cutting effect of an electromagnetic energy source 32, such as a laser driven by the flashlamp driving circuit 30, directed into an atomized distribution of fluid particles 34 above a target surface 3, as shown in
The flashlamp current generating circuit 30 of the present invention generates a relatively narrow pulse, which is on the order of 0.25 to 300 microseconds, for example. Additionally, the full-width half-max value of the optical output energy distribution 60 of the present invention preferably occurs within the first 70 microseconds, for example, compared to full-width half-max values of the prior art occurring within the first 250 to 300 microseconds. The relatively quick frequency, and the relatively large initial distribution of optical energy in the leading portion of each pulse of the present invention, results in efficient mechanical cutting. If a number of pulses of the output optical energy distribution 60 were plotted, and the average power determined, this average power would be relatively low, compared to the amount of energy delivered to the laser system via the high-voltage power supply 33. In other words, the efficiency of the laser system of the present invention may be less than typical prior art systems. Since the output optical energy distributions of the present invention are uniquely adapted for imparting electromagnetic energy into atomized fluid particles over a target surface, however, the actual cutting of the present invention is optimized. The cutting effect obtained by the output optical energy distributions of the present invention is both clean and powerful and, additionally, provides a consistent cut. The terms “cut” and “cutting” are broadly defined herein as imparting disruptive mechanical forces onto the target surface.
With reference to
Additionally, the present inventors have found that this orientation of the nozzle 71, pointed toward the target surface, enhances the cutting efficiency of the present invention. Each atomized fluid particle contains a small amount of initial kinetic energy in the direction of the target surface. When electromagnetic energy from the fiber optic guide 23 contacts an atomized fluid particle, the exterior surface of the fluid particle acts as a focusing lens to focus the energy into the water particle's interior. The focused electromagnetic energy is absorbed by the water particle, causing the interior of the water particle to heat and explode rapidly. This exothermic explosion cools the remaining portions of the exploded water particle. The surrounding atomized fluid particles further enhance cooling of the portions of the exploded water particle. A pressure-wave is generated from this explosion. This pressure-wave, and the portions of the exploded water particle of increased kinetic energy, are directed toward the target surface. The incident portions from the original exploded water particle, which are now traveling at high velocities with high kinetic energies, and the pressure-wave, can impart strong, concentrated, at least partially mechanical forces onto the target surface.
These at least partially mechanical forces can cause the target surface to break apart from the material surface through a “chipping away” action. The target surface does not undergo vaporization, disintegration, or charring. The chipping away process can be repeated by the present invention until the desired amount of material has been removed from the target surface. The nozzle 71 is preferably configured to produce atomized sprays with a range of fluid particle sizes narrowly distributed about a mean value.
Applicants have found that the distribution of particles imparted onto or directly in front of a fiber optic tip can form an interaction zone in front of the tip. The fiber optic serves to transport the concentrated electromagnetic energy through extraneous or stray fluid particles and into what Applicants refer to as an interaction zone, where high absorption of the electromagnetic energy subsequently occurs near to the target. Applicants have observed that the presently embodied electromagnetic radiation, which is highly absorbed by the specified fluid, and the combining of this electromagnetic radiation with the fluid particles at the tip of a fiber optic, will limit the penetration of the electromagnetic radiation through the mist to a predetermined depth. After this depth any electromagnetic radiation continuing through the mist is reduced or negligible, relative to the particular application at hand, during this cutting mode. As the electromagnetic radiation passes further and further into the interaction zone, its energy is absorbed more and more by the fluid particles, until hardly any, and eventually none, of the electromagnetic radiation remains. There is a point, or zone, wherein the thermal cutting forces are reduced substantially or eliminated, and wherein the cutting forces from the absorption of the electromagnetic radiation by the fluid particles, is optimal.
The high absorption of the electromagnetic energy by the fluid particles, resulting in expansion of the fluid particles, is a key element of one aspect of the present invention. A target must be placed within or near this interaction zone in order for the disruptive forces, from the absorption of the electromagnetic radiation by the fluid particles, to be optimally imparted onto the target surface.
One feature of the present invention is to maintain a bounded layer of fluid particles, which is not too thick and which is not too thin. The bounded layer of fluid particles may be of a relatively high density in order to optimize the absorption of electromagnetic energy in the layer and to ensure that substantial thermal cutting forces from the electromagnetic energy are attenuated or preferably substantially eliminated, being transformed into the fluid particles instead, so that the expansion of the fluid particles performs the cutting of the target surface. A relatively low-density distribution of fluid particles, spanning a relatively large distance, would absorb the incident electromagnetic radiation, resulting in fluid particles expanding well above the target surface. Any remaining radiation in the fluid particle distribution near the target surface would be too weak to induce the required high absorption and resulting cutting forces.
In addition to being bounded to enable the delivery of concentrated electromagnetic energy into the layer of fluid particles, the layer should be bounded to facilitate the very-close positioning of the target surface to the incident electromagnetic radiation. More particularly, the target surface should be placed at the boundary or within the interaction zone, so that the disruptive forces resulting from the expansion of the fluid particles occur near the target and do not need to travel far before being imparted onto the target. Thus, it can be seen that a fiber optic tip placed into a distribution of fluid particles and, additionally, placed in close proximity (2-3 mm, for example) of a target surface, creates a thin layer of fluid particles between the incident, concentrated electromagnetic energy and the target surface. Other distances are possible within the scope of the present invention, depending on, for example, the selected laser intensity and wavelength, the selected fluid, and the selected distribution of atomized fluid particles. The below embodiments disclose, for example, other means for creating a bounded layer of fluid particles between the incident, concentrated electromagnetic energy and the target surface.
Turning to
In the illustrated embodiment, the scanning housing 133 is placed directly onto or supported above the target, such as the patient's skin, and the motor 135 moves both the fiber optic 137 and the attached atomization nozzles 131, to achieve predetermined scanning patterns on the target. In the illustrated embodiment, the two atomization nozzles 131 are fixed to a fiber optic coupler 139 by arms, and the air and water lines 141 connected to the atomization nozzles 131 are flexible. Additionally, in one preferred embodiment, the fiber optic 137 from the laser within the scanning housing 133 is flexible to allow deflection by the motor 135. U.S. Pat. No. 5,474,549 and U.S. Pat. No. 5,336,217 disclose fibers that are deflected to achieve scanning patterns on a target surface. The entire contents of these two patents are incorporated herein by reference to illustrate structure which can be implemented by the present invention to achieve, for example, scanning.
A very broad aspect of the present invention comprises supplying an atomized distribution of fluid particles in the path of a beam to achieve electromagnetically induced cutting. The beam can be scanned, as shown in
The ring can be configured to comprise a mist disk, as discussed in connection with
In the embodiments of
The atomized fluid particles themselves are generally preferred to be on the order of microns in diameter. In a preferred embodiment, the atomized fluid particles have diameters within a range of about 40 to 60 microns. In other embodiments, the atomized fluid particles have diameters of approximately 200 microns. Other diameters are also possible in accordance with the present invention, so long as electromagnetically induced cutting is optimized for the desired application or maximized and thermal effects, preferably, are attenuated or eliminated during implementation of substantially non-thermal cutting operations. Since the electromagnetic energy from the laser is preferably highly absorbed by the atomized fluid particles, for the reduced-thermal mode of cutting, the layer of atomized fluid particles just above the target should be relatively thin in the presently preferred embodiment. In alternative embodiments, the layer of atomized fluid particles may be greater than 2 to 3 millimeters, but the amount of laser energy and/or characteristics of the distribution of atomized fluid particles may need to be adjusted accordingly so that cutting is maximized and thermal effects are attenuated or eliminated during implementation of substantially non-thermal cutting operations. For example, for a substantially thicker layer of atomized fluid particles a substantially greater laser energy concentration may need to be introduced to penetrate the greater thickness of the layer of atomized fluid particles and to generate the preferred cutting effects on the surface. The dynamic deflecting and focusing system may comprise, for example, one or more motors controlling one or more deflecting lenses, and/or one or more focusing optics, for focusing the deflected electromagnetic energy above the target surface just above or within the mist disk. Each motor can comprise a galvanic motor or stepper motor, for example.
In
The air and water lines may be placed closer to the fiber optic in alternative embodiments and may be configured in various orientations relative to one another, so long as fluid particles are generated in a distribution comprising a thin layer above the target surface. An additional air and water supply line is illustrated in phantom in
Delivery systems comprising hand-held pieces with few or no moving parts are disclosed in
In
As used herein, the term “hemispherical” is not intended to define half of a sphere but, rather, to define any closed surface with an opening for contacting the target surface. Thus, in an embodiment wherein the hemispherical configuration forms a rectangular edge for contacting the target surface, the enclosure may have any of a variety of shapes such as for example half or a sphere that transitions into the rectangular edge, or an open ended cubical enclosure with the rectangular edge. The general shapes constructions of the one or more contacting arms, as set forth in this paragraph, also apply to the embodiments described below with reference to
A moisture output 190 directs moist air and/or water or an atomized air/water spray into the path of the electromagnetic energy from the parabolic mirror or prism 188. Water from the moisture output 190 can help to allow the tissue contacting arms to slide over the target surface. In one embodiment, water or another fluid, or an additive to water, having lubricating properties, may be emitted from the moisture output 190. For example, soft water may be emitted from the moisture output 190. As presently preferred, the moisture output 190 comprises an atomizer for outputting atomized fluid particles into the path of the electromagnetic energy above or on the target surface 192, and the parabolic mirror or prism 188 focuses the electromagnetic energy into an interaction zone above, on or within (interstitially) the target surface 192. A suction 194 removes excess moist air and/or atomized fluid particles. The suction 194 is preferably disposed opposite to the moisture output 190 to facilitate a fluid flow path from the moisture output 190, through the interaction zone, and out through the suction 194.
At least one of the tissue contacting arms 212 comprises a proximal end 214, a distal end 216, and a suction passageway 218 extending therebetween. Each suction passageway 218 is preferably constructed to carry surplus fluids and debris from the target surface. In order to facilitate this end, one or more of the rounded surfaces (e.g., ball rollers) at the distal ends 216 may be configured to have a smaller or flatter profile to place the relative position(s) of the suction passageway 218 opening(s) closer to the target surface. In one embodiment, the opening or openings of the suction passageway(s) 218 may be placed within the rounded surface(s) or ball roller(s) at the distal end(s) 216. Each suction passageway 218 removes water particles that have been emitted from the mixing chamber 210 and carries them proximally through the suction passageway 218 and out of the handpiece 198. Another suction passageway may be disposed in a second tissue contacting arm 220.
Additional tissue contacting arms may be implemented, such as a third tissue contacting arm, with or without additional suction passageways. In another embodiment, the tissue contacting arms are part of and form an enclosure, such as a hemispherical enclosure. The distal ends of the tissue contacting arms are preferably rounded or smooth-surfaced to allow the tissue contacting arms to slide over the target surface, such as a patient's skin. In a modified embodiment, one or more of the distal ends may comprise a ball roller. Regardless of the shape of the distal end of the tissue contacting arm, water from the moisture output 210 (or, for example, the moisture output 190 of
As an alternative to the mixing chamber 210 of
For example, with reference to
In
The hand-held piece 230 preferably comprises an air line 242 and a water line 244 both of which feed into a mixing chamber 246 for mixing thereof, and for the subsequent emission of water particles from the moisture output 248, preferably into an interaction zone within the path of electromagnetic radiation from the lens 234. A vacuum source 250 is preferably disposed in at least one of the tissue contacting arms 240. The vacuum source 250 is preferably constructed, and disposed at a height, sufficient to remove excess water and not to interfere with the target surface. As with the embodiments of
As an alternative to the mixing chambers 246, mist disks, such as illustrated in
The mist disks for use with the hand-held piece 230 may comprise feet 262, as shown in
As with the embodiments of
The illustrated embodiment of
In other modified embodiments, single-nozzle moisture outputs oriented to output distributions of fluid particles preferably in directions substantially perpendicular to directions of incidence of the electromagnetic radiation, such as shown in
In other modified embodiments, only a single line, as distinguished from separate water and separate air lines, is used to deliver moist air. The moist air may comprise a colloidal suspension of water droplets, very humid air (about 100% humid), cool or cold steam as from a cold humidifier, or water vapor from dry ice. A pulsing valve may be incorporated to control the delivery of fluid. In another embodiment, a mono-water droplet dispersor may be used to supply single droplets, or droplets of relatively small numbers, to the interaction zone. Sprays can be used which are fed only by water without any assistance by an air line. A nebulizer, which uses air pressure and water to output atomized fluid particles through a small orifice, can be implemented. The nebulizer may comprise an ultrasonic or sonic device, and the atomized fluid particles may comprises water droplets having diameters ranging from about 5 to about 20 microns, or larger.
In accordance with the present invention, the fluid particles placed above the target surface may comprise materials other than, or in addition to, water. The fluid may comprise, for example, a medicated substance, a sterilized substance, or an anesthetic. U.S. Pat. No. 5,785,521 is expressly incorporated herein by reference to disclose, for example, various means and types of conditioned fluids which may be used in conjunction with a source of electromagnetic energy.
The present invention, which implements electromagnetically induced cutting to cut, remove, or otherwise impart disruptive forces onto relatively large surface areas of an epidermis, can be implemented on other target surfaces as well.
The present invention is not intended to be limited to operating on skin, or even tissue. One preferred application, however, involves removing tissue from relatively large surface areas of the epidermis for cosmetic purposes. For example, cosmetic surgery may be implemented using the present device on the face of a patient. Other conventional means for scanning a collimated or non-collimated beam, which are not disclosed above, may be implemented for achieving this purpose. The apparatus of the present invention, however, differs from the prior art in implementing the distributions of fluid particles or moist air between or within the impinging electromagnetic energy and the target surface. A particular laser source, as disclosed in U.S. application Ser. No. 08/903,187 is preferred, the contents of which are expressly incorporated herein by reference.
In a presently preferred embodiment of cosmetic surgery on the epidermis of a patient, the fluid particles or moist air may comprise at least one anesthesia and/or medication. Medications can include drugs for relieving pain (analgesics), such as Acetaminophen; drugs for causing a loss of general sensation (anesthetics) and vasal constrictors, such as lidocaine, epinephrine, or a combination of lidocaine and epinephrine; and substances able to kill or inhibit growth of certain microorganisms (antibiotics), such as penicillin or tetracycline. In the category of anesthetics, one composition would comprise lidocaine+diethyl-amimacet-2,6-xylidins. Epinephrine can be added to this composition, and the resulting product may provide an anesthetic affect for a period from about 45 minutes to 3 hours. Amino esters may also be used as anesthetics in other embodiments, wherein such amino esters may comprise, for example, procaine, 2-chloroprocaine and/or tetracine. In other embodiments, lidocaine can be combined with one or more of prilocaine, etidocaine, mepiracaine and bupivacaine. The medications can be emitted from a separate channel and/or orifice, or can be emitted from the moisture outputs.
In one embodiment of the present invention, botulinum toxin can be emitted from the moisture outputs, preferably on a final pass, for preventing wrinkling of the skin during healing. Botulinum toxin is a generic term embracing the family of toxins produced by the anaerobic bacterium Clostridium botulinum and, to date, seven immunologically distinct neurotoxins serotype have been identified. These have been given the designations A, B, C, D, E, F and G. For further information concerning the properties of the various botulinum toxins, reference is made to the article by Jankovic and Brin, The New England Journal of Medicine, Vol. 324, No. 17, 1990, pp. 1186-1194, and to the review by Charles L. Hatheway in Chapter 1 of the book entitled Botulinum Neurotoxin and Tetanus Toxin, L. L. Simpson, Ed., published by Academic Press Inc. of San Diego, Calif., 1989, the disclosures in which are incorporated herein by reference. Botulinum toxin is obtained commercially by establishing and growing cultures of C. botulinum in a fermenter and then harvesting and purifying the fermented mixture in accordance with known techniques. Botulinum toxin type A, the toxin type generally utilized in treating neuromuscular conditions, is currently available commercially from several sources; for example, from Porton Products Ltd. UK, under the trade name “DYSPORT,” and from Allergan, Inc., Irvine, Calif., under the trade name BOTOX.®. Botulinum Toxin Type A purified complex. In other embodiments, any of the serotypes B through G of Botulinum neurotoxin may be used, as well. The medications can be emitted from a separate channel and/or orifice, or can be emitted from the moisture outputs.
When multiple passes of the electromagnetically induced cutter are conducted over the surface being ablated, the medication and/or anesthesia within the atomized fluid particles is continuously delivered onto the tissue, to thereby hydrate, relax, medicate, and/or otherwise treat or medicate the tissue. In alternative embodiments, the mist is applied only on the second (e.g., immediately following) and subsequent (e.g., immediately following) passes over the surface. The mist may be applied at selected times during a single pass, and/or may be applied during selected passes (e.g., consecutive passes immediately following one another) of the laser over the surface. Similarly, the type of conditioning of the fluid may be selectively applied.
According to one aspect of the present invention, materials can be removed in one embodiment from a target surface by cutting forces different from conventional thermal cutting forces. In another embodiment, the apparatus of the present invention can be used to impart thermal energy onto the tissue subsequent to (e.g., immediately following) the substantially non-thermal cutting or ablating, for inducing deep cutting and coagulation, for example. For example, a first scan can induce non-thermal or reduced thermal cutting, and a subsequent (e.g., immediately following) scan can be used to apply thermal energy to the surface for inducing coagulation. In yet another embodiment, a reduced amount of atomized fluid particles (or moisture) may be used to simultaneously impart a combination of at least partially mechanical cutting (from expanding moisture) and thermal cutting (from the laser to impart coagulation, for example).
In one particular embodiment, a first pass over the surface of primarily non-thermal cutting is implemented with the fluid from the moisture output preferably comprising an anesthetic and a vasal constrictor (e.g., epinephrin). In this first pass, portions of the epidermis are preferably removed. A second pass is then (e.g., immediately following the first pass) performed, preferably with a lesser amount of fluid from the moisture output. The fluid is slightly or moderately reduced, or even eliminated, for greater cutting of the dermal layer of the skin and coagulation of vessels. For deeper wrinkles, additional passes (e.g., consecutive passes immediately following one another) similar to the second pass can be performed. Any of the above mentioned forms of Botulinum neurotoxin may be used an any point in time, such as, for example, as an after or in-between-laser treatment, to maintain skin smoothness. Prior art lasers typically do not apply any medication medium during the passing of laser over the skin, thereby causing the skin to become irritated and red. In contrast to prior art lasers which typically impart thermal cutting forces onto the skin, the electromagnetically induced cutter of the present invention, when operated in a non-thermal or reduced-thermal cutting mode in accordance with one aspect of the present invention, preferably does not deliver any substantial amount of heat to the tissue. As mentioned above, in this cutting mode the exploded atomized fluid particles are cooled by exothermic reactions before they contact the target surface. Thus, in accordance with one aspect of the present invention, atomized fluid particles of the present invention are heated, expanded, and cooled before contacting the target surface. Prior-art devices, which thermally operate on the skin, may have negative side effects associated therewith in connection with the medical procedure and the subsequent healing of the tissue. The present invention may, additionally, be able to ablate extremely thin layers of tissue, relative to existing laser skin surgery devices. Moreover, the non-thermal or reduced-thermal cutting mode, as a result of the mechanical cutting mechanism achieved from the expanding fluid particles, may be configured to cut at a particular depth of skin, so that only the crests of wrinkles are removed and part or all of the valleys are left in tact. The mechanical cutting nature of the non-thermal or reduced-thermal cutting mode may also be able to more evenly cut through hair and hair follicles, to thereby more evenly ablate the skin surface.
In accordance with one aspect of the present invention, substantially non-thermal cutting or reduced-thermal cutting alone, or in combination with the medicated atomized fluid particles, can serve to reduce erythema (skin redness) and reduce edema (swelling). Moreover, the present invention in accordance with one embodiment can serve to reduce unwanted thermal damage to adjacent tissue. For example, direct and/or adjacent melanocytes may not be substantially thermally affected with the present invention, thus attenuating hypo or hyper pigmentation effects, which can occur with prior-art chemical peel, derma-abrasion (use of wire brush), and thermal-cutting laser procedures. The present invention further can serve to reduce post and intra-operative pain and discomfort. For example, burning sensations and effects experienced by the patient can be attenuated.
Relatively small surface areas, or small thicknesses, of the skin may be treated in low wattage modes. Additionally, a relatively small amount of fluid may be used. Alternatively, the electromagnetic energy may be applied in a defocused mode, for a net decrease in energy density on the target surface.
The above-mentioned delivery of the atomized fluid particles, which may comprise medication and/or anesthesia, onto the skin during or close in time with the cutting or ablating operation serves to hydrate, relax, medicate, and/or otherwise treat or medicate the tissue. The atomized fluid particles may be delivered into the interaction zone contemporaneously with each pulse of electromagnetic radiation or, alternatively, may be continuously delivered into the interaction zone.
Although the hydration of the soft tissue is a benefit in accordance with one aspect of the present invention, too much water can interfere with the optimal execution of the medical procedure. A percentage of the atomized fluid particles not within the path of the electromagnetic radiation will accumulate on the surface of the target surface. Suction from the vacuum sources can be used to remove excess or unwanted liquid from the target surface or adjacent areas. Cut tissue can be carried by the excess water and removed by the suction. In one embodiment, the target surface can be oriented so that gravity will drain off unwanted liquid. The suction is preferably additionally, or alternatively, used to remove airborne atomized fluid particles that are not in the interaction zone. One or more suction channels may be placed in a mist disk, as mentioned above, for removing unwanted, airborne atomized fluid particles not within the path of the electromagnetic energy. The suction channels may be placed between moisture output channels at the same height, or at different heights in which case the suction channels may also be placed directly above or below the moisture outputs channels. Utilization of the above-mentioned moist air, alone or in combination with atomized fluid particles, may help to attenuate an amount of excess fluid accumulating on the target surface.
Although an exemplary embodiment of the invention has been shown and described, many other changes, modifications and substitutions, in addition to those set forth in the above paragraphs, may be made by one having ordinary skill in the art without necessarily departing from the spirit and scope of this invention.
This application is a continuation-in-part of co-pending U.S. application Ser. No. 11/523,492, filed Sep. 18, 2006 and entitled ELECTROMAGNETIC ENERGY DISTRIBUTIONS FOR ELECTROMAGNETICALLY INDUCED MECHANICAL CUTTING (Att. Docket BI9066CON4), which is commonly assigned and the contents of which are expressly incorporated herein by reference. This application is also a continuation-in-part of co-pending U.S. application Ser. No. 11/475,719, filed Jun. 26, 2006 and entitled VISUAL FEEDBACK IMPLEMENTS FOR ELECTROMAGNETIC ENERGY OUTPUT DEVICES (Att. Docket BI9936P), and U.S. application Ser. No. 09/848,010, filed May 2, 2001 and entitled DERMATOLOGICAL CUTTING AND ABLATING DEVICE (Att. Docket BI485P), both of which are commonly assigned and the contents of which are expressly incorporated herein by reference.
Number | Date | Country | |
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Parent | 11523492 | Sep 2006 | US |
Child | 11821409 | US | |
Parent | 11475719 | Jun 2006 | US |
Child | 11523492 | US | |
Parent | 09848010 | May 2001 | US |
Child | 11475719 | US |