The present invention relates to an evaporation prevention mechanism, a specimen storage mechanism, and a specimen storage and transport device.
In order to guarantee analysis accuracy of an automatic analyzer, a quality control (QC) specimen measurement is necessary, in which a concentration is adjusted about several times a day or every time a sample measurement is performed a predetermined number of times. Since it is necessary to perform the QC specimen measurement for each analysis item, the QC specimen measurement is a steady operation with a high load in laboratory work. For this reason, a specimen storage and transport device that stores the QC specimens in the automatic analyzer and transports the QC specimens to an analysis unit as necessary may be provided.
PTL 1 discloses a cooling storage assembly that cools and stores controls and calibrators. PTL 2 discloses a specimen analyzer that effectively prevents evaporation of a reagent in a state where an opened reagent holder is placed in the specimen analyzer.
PTL 1: JP2019-525116A
PTL 2: JP2020-51956A
A specimen storage mechanism for storing the QC specimens is required to prevent evaporation during a storage period of the QC specimens and keep the concentration constant. However, although a method of directly covering a specimen tube with a lid has a high evaporation prevention effect, there is a concern that carry-over occurs when the lid is reused for another QC specimen. On the other hand, when a disposable lid is used, an increase in consumables and a mechanism or a space for discarding are required.
In the cooling storage assembly disclosed in PTL 1, evaporation of a specimen is prevented by an evaporation cover. However, a drain for discharging dew condensation water from a tube slot is provided in a bottom surface of the tube slot. No unit for preventing a progress of the evaporation of the QC specimen by air exchange through the drain is provided.
A lid portion disclosed in PTL 2 uses a shape of the reagent holder to cover an opening of the reagent holder in a non-contact manner. Specifically, a shape of a shoulder of the reagent holder is used to place the lid portion on the reagent holder. On the other hand, a specimen tube accommodating the QC specimen generally has a cylindrical shape such as a test tube, and it is difficult to place a lid covering the opening on an upper end of the specimen tube in the non-contact manner.
An object of the invention is to provide an evaporation prevention mechanism that prevents evaporation during specimen storage without causing carry-over, a specimen storage mechanism, and a specimen storage and transport device.
An evaporation prevention mechanism according to one embodiment of the invention that accommodates a cylindrical specimen tube accommodating a specimen includes: a cylindrical storage holder that connects an upper opening and a lower opening; a lid that covers the upper opening; a seal member attached to the lower opening; and a bottom receiving member. The specimen tube is inserted into the storage holder from the upper opening, the seal member is in close contact with a side surface of the specimen tube, a bottom portion of the specimen tube is in contact with the bottom receiving member, and the specimen tube is accommodated in a state in which an upper end of the specimen tube is not in contact with the lid.
Provided is an evaporation prevention mechanism that prevents evaporation during specimen storage without causing carry-over, a specimen storage mechanism, and a specimen storage and transport device. Other problems and novel features will become apparent from description of the present specification and the accompanying drawings.
In the example in
The specimen tube 3 loaded into the specimen storage and transport device 1 via the rack transport mechanism 5 is taken out of the sample rack 4 by the specimen tube transport mechanism 6. The taken-out specimen tube 3 is held by the specimen tube transport mechanism 6, and the specimen tube transport mechanism 6 holding the specimen tube 3 moves on a specimen tube transport mechanism base 7, thereby transporting the specimen tube 3 to the refrigerator 8. A shutter 9 that can be opened and closed is provided in a part of a cover of the refrigerator 8, and the shutter 9 is opened when the specimen tube transport mechanism 6 accesses an inside of the refrigerator. In the example in
After the shutter 9 is opened, the specimen tube transport mechanism 6 stores the specimen tube 3 in an evaporation prevention mechanism disposed inside the refrigerator.
Although a detailed configuration of the evaporation prevention mechanism 12 will be described later, the specimen tube 3 can be individually stored in the evaporation prevention mechanism. When the specimen tube transport mechanism 6 accesses the evaporation prevention mechanism, a lid of the evaporation prevention mechanism is opened by a lid opening and closing mechanism 10 in advance, and the lid of the evaporation prevention mechanism 12 is closed by the lid opening and closing mechanism 10 after a storage operation or a taken-out operation of the specimen tube with respect to the evaporation prevention mechanism performed by the specimen tube transport mechanism 6 is completed.
After an operation of transporting the specimen tube 3 into the refrigerator 8 or an operation of removing the specimen tube 3 from the refrigerator 8 is completed, the refrigerator 8 is closed by closing the shutter 9. However, when the operation of transporting the specimen tube 3 into the refrigerator 8 or the operation of removing the specimen tube 3 from the refrigerator 8 is continuously performed a plurality of times, the shutter 9 may be kept in an open state until a series of operations are completed.
A first embodiment of the evaporation prevention mechanism 12 will be described with reference to
The bottom receiving portion 103 includes a flange 103f, a support member 103p, and a bottom receiving member 103b. The bottom receiving member 103b is a member that supports a bottom portion of the specimen tube 3 stored in the evaporation prevention mechanism 12, and is provided with a hole 105 that is a contact position of the bottom portion of the specimen tube 3. Here, when the bottom portion of the specimen tube 3 is inserted into the hole 105, the bottom portion of the specimen tube 3 is positioned and supported. Instead of the hole 105, an annular protrusion may be provided to position and support the specimen tube 3. The bottom receiving member 103b is fixed to the flange 103f by one or more support members 103p, and the flange 103f and the flange 101f of the storage holder 101 are fixed to each other by support poles 106. When a center of the hole 105 supporting the bottom portion of the specimen tube 3 is referred to as a center of the bottom receiving member 103b, the bottom receiving member 103b is fixed such that the center of the bottom receiving member 103b coincides with a center axis X of the small diameter portion 101B of the storage holder 101. Accordingly, the specimen tube 3 stored in the evaporation prevention mechanism 12 is stably stored in a vertical state. Although the example in which the flanges are coupled to each other by the support poles is shown as a method of fixing the storage holder 101 and the bottom receiving portion 103, the method is not limited thereto.
The storage of the specimen tube in the evaporation prevention mechanism 12 is performed by the specimen tube transport mechanism 6 inserting the specimen tube 3 from above in a vertical direction into the evaporation prevention mechanism 12 in which the lid 104 is opened by the lid opening and closing mechanism 10. The specimen tube transport mechanism 6 expands the seal portion 102s of the seal member 102 and inserts the specimen tube 3, and ends an insertion process of the specimen tube 3 when the bottom portion of the specimen tube 3 comes into contact with the bottom receiving member 103b and does not advance any further. Thereafter, the specimen tube transport mechanism 6 separates the specimen tube 3 and moves away from the evaporation prevention mechanism 12. The lid opening and closing mechanism 10 closes the lid 104 of the evaporation prevention mechanism 12. FIGS. A and 4B show the evaporation prevention mechanism 12 (first embodiment) in a state where the specimen tube 3 is stored therein and the lid 104 is closed, in which
In the state where the specimen tube 3 is stored, the seal member 102 seals a side surface of the specimen tube 3 without a gap by expanding the seal portion 102s. Therefore, when the specimen tube 3 is inserted, friction occurs between the seal portion 102s and the side surface of the specimen tube 3 in contact therewith. Normally, a specimen identification label (not shown) for identifying the accommodated QC specimen is attached to the side surface of the specimen tube 3. In the state where the specimen tube 3 is stored in the evaporation prevention mechanism 12, the specimen identification label is preferably located above the seal member 102. Accordingly, it is possible to prevent rubbing caused by the specimen identification label coming into contact with the seal portion 102s at the time of insertion and taken-out of the specimen tube 3. Further, when the seal member 102 seals the specimen tube 3 at the position where the specimen identification label is attached, there is a possibility that seal performance deteriorates due to a twist of the specimen identification label or the like, and this possibility can be prevented.
The seal member 102 is in close contact with the side surface of the specimen tube 3, so that rotation of the specimen tube 3 in the storage holder 101 can be prevented. Accordingly, when the specimen identification label is a label on which a bar code is displayed, a direction in which the bar code is displayed can be kept constant, and when the specimen tube is taken out of the storage holder 101 and the specimen identification label is read, the specimen identification label can be read without detecting a bar code position or the like. The specimen tube 3 is supported by the seal member 102 and the bottom receiving member 103b, the center of the bottom receiving member 103b coinciding with the center axis X of the small diameter portion 101B of the storage holder 101, so that the specimen tube 3 is stably stored in the evaporation prevention mechanism 12 in the vertical state. Accordingly, handling accuracy of the specimen tube 3 by the specimen tube transport mechanism 6 can be improved.
A diameter and a height of the large diameter portion 101A of the storage holder 101 are determined so as to have sizes not hindering the operations of the specimen tube transport mechanism 6 that handles the specimen tube 3. As described above, the sizes of the large diameter portion 101A of the storage holder 101 need to be determined in advance so as not to hinder the operations of the specimen tube transport mechanism 6 that holds the specimen tube 3 and inserts the specimen tube 3 into the storage holder 101. A space around the specimen tube 3 in a state where the specimen tube 3 is stored in the evaporation prevention mechanism 12 is a system closed from an external environment by the storage holder 101, the seal member 102, and the closed lid 104, and is referred to as a storage region. As a volume of the storage region is smaller, an evaporation amount of the QC specimen from the specimen tube 3 can be further prevented. Therefore, it is desirable that the diameter and the height of the large diameter portion 101A of the storage holder 101 are set to be minimum sizes so as to not hinder the operations of the specimen tube transport mechanism 6, and the diameter of the small diameter portion 101B is also set to an extent of being slightly larger than the outer diameter of the specimen tube 3. For example, the diameter of the large diameter portion 101A of the storage holder 101 shown in the drawing increases from a connection portion (step) with the small diameter portion 101B toward the upper opening, but the invention is not limited thereto, and a shape and a size of the diameter of the large diameter portion 101A can be determined such that a volume of the large diameter portion 101A decreases according to the shape of the specimen tube transport mechanism 6 and the operations during the transport and removal.
Further, as shown in
On the other hand, after the specimen tube 3 is taken out, since a lower end of the storage holder 101 is opened, dew condensation water generated in the storage region is discharged from the storage holder 101. Therefore, it is not necessary to provide a drain for discharging the dew condensation water in the storage region. If the drain is provided in the evaporation prevention mechanism 12, air can be exchanged between an inside and an outside of the storage region even when the specimen tube 3 is stored, and the evaporation amount of the QC specimen increases, and thus it is not desirable to provide the drain.
A second embodiment of the evaporation prevention mechanism 12 will be described with reference to
The bottom receiving member 201 is shared by the plurality of evaporation prevention mechanisms 12 in this manner, so that there is an advantage that the structure of each evaporation prevention mechanism 12 can be simplified. In this case, the specimen storage disk 11 and the storage holder 101 of the evaporation prevention mechanism 12 may be integrally formed.
Hereinafter, modifications of the evaporation prevention mechanism 12 will be described. In the following modifications, the description of the bottom receiving member may be omitted, which may be provided to the evaporation prevention mechanism 12 as in the first embodiment, or the bottom receiving member common to the plurality of evaporation prevention mechanisms 12 may be provided as in the second embodiment. In addition, the evaporation prevention mechanism may be provided on the specimen storage disk having a disk shape, or the storage holder of the evaporation prevention mechanism may be formed integrally with the specimen storage disk.
A storage holder 301 in the present modification has a simple shape with no step, and the small diameter portion of the storage holder 101 in the first embodiment and the second embodiment is removed, so that the storage holder 301 in the present modification can be easily manufactured. It is effective in a case where a defect related to the specimen identification label due to the removal of the small diameter portion is allowable, or in a case where the specimen identification label can be downsized and the specimen identification label can be contained in the storage region.
A second modification of the evaporation prevention mechanism 12 will be described with reference to
In the second modification, since it is possible to secure a region for the specimen tube transport mechanism 6 to access the evaporation prevention mechanism 12 by removing the cap 404, it is not necessary to separately provide a region for avoiding interference of the specimen tube transport mechanism 6 in the evaporation prevention mechanism 12. Therefore, a diameter of the storage holder 401 can have a size slightly larger than the outer diameter of the specimen tube 3, the volume of the storage region can be reduced, and the evaporation amount of the QC specimen from the specimen tube 3 can be effectively reduced.
The invention is not limited to the specific embodiments described above, and includes various modifications. For example, the specific embodiments described above have been described in detail to facilitate understanding of the invention, and the invention is not necessarily limited to those including all the described configurations. A part of the configuration of one specific embodiment can be replaced with the configuration of another specific embodiment, and the configuration of another specific embodiment can be added to the configuration of one specific embodiment. A part of a configuration in each specific embodiment may be added to, deleted from, or replaced with another configuration. For example, a liquid accommodated in a cylindrical holder is useful for storage of specimens other than the QC specimens and other specimens.
| Number | Date | Country | Kind |
|---|---|---|---|
| 2022-025552 | Feb 2022 | JP | national |
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/JP2022/045136 | 12/7/2022 | WO |