Suzuki et al. Arthritis Rheum. 41: 344-353, (abstract), 1998. |
Takahashi et al. Eur. J. Immunol. 23: 1935-1941, 1993. |
Uehara et al. J. Immunol. 150: 3243-3253, 1993. |
Clin. Lab. International 18 (4): pp. 10, abstract, 1994. |
Clin. Lab. International 19 (4): pp. 12, abstract with Kamiya Biomedical Product Brochure for ZB4, 1994. |
Dhein et al., "Induction of Apoptosis By Monoclonal Antibody Anti-APO-1 Class Switch Variants is Dependent on Cross-Linking of APO-1 Cell Surface Antigens.sup.1," J. Immunology, 149(10):3166-3173 (1992). |
Itoh et al., "The Polypeptide Encoded by the cDNA for Human Cell Surface Antigen Fas Can Mediate Apoptosis," Cell, 66:233-243 (1991). |
Klas et al., "Activation interferes with the APO-1 pathway in mature human T cells," International Immunology, 5:625-630 (1993). |
Kobayashi et al., "Anti-Fas monoclonal antibody is cytocidal to human immunodeficiency virus-infected cells without augmenting viral replication," Proc. Natl. Acad. Sci. USA, 87:9620-9624 (1990). |
Miyawaki et al., "Differential Expression of Apoptosis-Related Fas Antigen on Lymphocyte Subpopulations in Human Peripheral Blood.sup.1," J. Immunology, 149(11):3753-3758 (1992). |
Ogasawara et al., "Lethal effect of the anti-Fas antibody in mice," Nature, 364:806-809 (1993). |
Trauth et al., "Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis," Science, 245:301-305 (1989). |
Yonehara et al., "A Cell-Killing Monoclonal Antibody (Anti-Fas) to a Cell Surface Antigen Co-Downregulated With the Receptor of Tumor Necrosis Factor," J. Exp. Med., 169:1747-1756 (1989). |
Owen-Schaub et al., "DNA Fragmentation and Cell Death is Selectively Triggered in Activated Human Lymphocytes by Fas Antigen Engagement," Cellular Immunology, 140:197-205 (1992). |
Jian et al., "The Fas-Ligand and Apoptosis in LPR and GLD Mice," Arthritis & Rheumatism. 36 (9):s52, Abstract No. 80 (1993). |
Zhou et al., "Fas.sup.+ Cos Cells and Anti-Fas Antibody for In Vivo Localization of Fas/Fas Ligand Binding and Antipoptosis Sites in Autoimmune LPR and GLD Mice," Arthritis & Rheumatism, 36 (9):s52, Abstract No. 81 (1993). |
Sevier et al., "Monoclonal Antibodies in Clinical Immunology," Clin. Chem., 27(11):1797-1806 (1981). |
Allen et al., "Differences Defined by Bone Marrow Transplantation Suggest that Ipr and gld are Mutations of Genes Encoding an Interacting Pair of Molecules," J. Exp. Med., 172:1367-1375 (1990). |
Winter et al., "Antibody-based Therapy, Humanized antibodies," TIPS, 14:139-143 (1993). |
Alderson et al., "Fas Tranduces Activation Signals in Normal Human T Lymphocytes," J. Exp. Med., 178:2231-2235 (1993). |
Rhein, R. "Another sepsis drug down--Immunex' TNF receptor," Biotechnology Newswatch, pp. 1 and 3 (Oct. 4, 1993). |
Itoh et al., "Effect of bcl-2 on Fas Antigen-Mediated Cell Death.sup.1," J. Immunol., 151(2):621-627 (1993). |
Laurence et al., "Plasma From Patients With Idiopathic and Human Immunodeficiency Virus-Associated Thrombotic Thrombocytopenic Purpura Induces Apoptosis in Microvascular Endothelial Cells," Blood, 87(8):3245-3254, Apr. 15, 1996. |
Katsikis et al., "Fas Antigen Stimulation Induces Marked Apoptosis of T Lymphocytes in Human Immunodeficiency Virus-infected Individuals," J. Exp. Med., 181:2029-2036, Jun. 1995. |
Lynch, David H., "Biology of Fas," Circulatory Shock, 44:63-66 (1995). |
Lynch et al., "Fas and FasL in the homeostatic regulation of immune responses," Immunology Today, 16(12):569-574 (1995). |
Ramsdell et al., "Differential ability of T.sub.h 1 and T.sub.h 2 T cells to express Fas ligand and to undergo activation-induced cell death," International Immunology, 6(10):1545-1553, Oct. 1994. |
Alderson et al., "Fas Ligand Mediates Activation-induced Cell Death in Human T Lymphocytes," J. Exp. Med., 181:71-77, Jan. 1995. |
Alderson et al., "Regulation of apoptosis and T Cell activation by Fas-specific mAb", International Immunology, 6(11):1799-1806, Nov. 1994. |
Ramsdell et al., "gld/gld mice are unable to express a functional ligand for Fas," Eur. J. Immunol., 24:928-933, Apr. 1994. |
Lynch et al., "Immunoregulatory Effects of Fas-Mediated Signaling," Journal of Cellular Biochemistry, 60:39-46 (1996). |
Nishio et al., "A Possible Involvement of Fas-Fas Ligand Signaling in the Pathogenesis of Murine Autoimmune Gastritis," Gastroenterology, 111:959-967 (1996). |
Badley et al., "Upregulation of Fas Ligand Expression by Human Immunodeficiency Virus in Human Macrophages Mediates Apoptosis of Uninfected T Lymphocytes," Journal of Virology, 70(1):199-206, Jan. 1996. |
Glynn et al., "Apoptosis Induced by HIV Infection in H9 T Cells Is Blocked by ICE-Family Protease Inhibition but Not by a Fas (CD95) Antagonist.sup.1," Journal of Immunology, 157:2754-2758 (1996). |
Gulizia et al., "The Envelope gp120 Gene of Human Immunodeficiency Virus Type 1 Determines the Rate of CD4-Positive T-Cell Depletion in SCID Mice Engrafted with Human Peripheral Blood Leukocytes," Journal of Virology, 70(6): 4184-4187 (1996). |
Mosier et al., "Pathogenesis of CD4 T Cell Depletion in Hu-PBL-SCID Mice," Molecular Immunology of Virus Infections, p. 42. |
De Maria et al., "Functional Expression of Fas and Fas Ligand on Human Gut Lamina Propria T Lymphocytes," J. Clin. Invest., 97(2):316-322, Jan. 1996. |
Boshell et al., "Effects of antigen presentation of superantigen-induced apoptosis mediated by Fas/Fas ligand interactions in human T cells," Immunology, 87:586-592 (1996). |
Laurence et al., "Apoptotic Depletion of CD4+ T Cells in Idiopathic CD4+ T Lymphocytopenia," J. Clin. Invest., 97(3):672-680 (1996). |
Mitra et al., "HIV-1 upregulates Fas ligand expression in CD4+ T cells in vitro and in vivo: association with Fas-mediated apoptosis and modulation by aurintricarboxylic acid," Immunology, 87:581-585 (1996). |
Glass et al., "Regulation of the Fas Lytic Pathway in Cloned CTL," Journal of Immunology, 156:3638-3644 (1996). |
Boudet et al., "Apoptosis associated with ex vivo down-regultion of Bcl-2 and up-regulation of Fas in potential cytotoxic CD8+ T lymphocytes during HIV infection," J. Immunol., 156(6):2282-2293 (1996). |
Baumler et al., "Activation of the CD95 (APO-1/Fas) system in T cells from human immunodeficiency virus type-1-infected children," Blood, 88(5):1741-1746, Sep. 1, 1996. |
Estaquier et al., "Fas-mediated apoptosis of CD4+ and CD8+ T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists," Blood, 87(12):4959-4966, Jun. 15, 1996. |
Estaquier et al., "T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons," J. Exp. Med., 182(6):1759-1767, Dec. 1995. |
Westendorp et al., "Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gpl20," Nature, 375:497-500, Jun. 8, 1995. |
Ehret et al., "Resistance of chimpanzee T cells to human immunodeficiency virus type 1 Tat-enhanced oxidative stress and apoptosis," J. Virol., 70(9):6502-6507, Sep. 1996. |
Dhein et al., "Molecular mechanisms of APO-1/FAS(CD95)-mediated apoptosis in tolerance and AIDS," Behring Inst. Mitt., 96:13-20 (1995). |
Oyaizu et al., "Mechanism of apoptosis in peripheral blood mononuclear cells of HIV-infected patients," Adv. Exp. Med. Biol., 374:101-114 (1995). |
Weiss, Robin A., "How Does HIV Cause AIDS?" Science, 260:1273-1279, May 28, 1993. |
Smith et al., "The TNF Receptor Superfamily of Cellular and Viral Proteins: Activation, Costimulation, and Death," Cell, 76:959-962, Mar. 25, 1994. |
Drappa et al., "The Fas Protein is Expressed at High Levels on Double-Positive Thymocytes and Activated Mature T Cells in Normal but not MRL/lpr Mice," Arthritis & Rheumatism, 36(9):s52, Abstract No. 79 (1993). |
Galle et al., "Involvement of the CD95 (APO-1/Fas) Receptor and Ligand in Liver Damage," J. Exp. Med., 182:1223-1230, Nov. 1995. |
Watanabe-Fukunaga et al., "Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis," Nature, 356:314-317, Mar. 26, 1992. |
Meyaard et al., "Programmed Death of T Cells in HIV-1 Infection," Science, 257:217-219, Jul. 10, 1992. |
Groux et al., "Activation-induced Death by Apoptosis in CD4+ T Cells from Human Immunodeficiency Virus-infected Asymptomatic Individuals," J. Exp. Med., 175:331-340, Feb. 1992. |
Yonehara et al., "Biological Significance of Cell Surface Apoptosis Antigen Fas," Journal of Cellular Biochemistry, Suppl. 17B, p51, 1993. |
Ameisen et al., "Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis," Immunology Today, 12(4):102-105 (1991). |
King et al., "Signaling for death of lymphoid cells," Current Opinion in Immunology, 5:368-373 (1993). |
Crispe, I. Nicholas, "Fatal Interactions: Fas-Induced Apoptosis of Mature T Cells," Immunity, 1:347-349, Aug. 1994. |
Gougeon et al., "Apoptosis in AIDS," Science, 260:1269-1270, May 28, 1993. |
Suda et al., "Molecular Cloning and Expression of the Fas Ligand, a Novel Member of the Tumor Necrosis Factor Family," Cell, 75:1169-1178, Dec. 17, 1993. |
Kobayashi et al., "AIDS and other Viral Infections and Cell Death," Nikkei Science, pp. 34-41, Jun. 1993. |
Data from Dr. John Krowka, Calif. Dept. of Health Services. |
Data from Dr. Patricia Fultz, University of Alabama at Birmingham. |
Cory, Suzanne, "Fascinating death factor," Nature, 367:317-318 (1994). |
Badley et al., "HIV-Infected Macrophages Specifically Kill CD4 Lymphocytes from HIV Seropositive Patients Through Both Fas and TNF," XI International Conference on AIDS, Vancouver, B.C., Jul. 1996, Abstract No. We.A.260. |
Algeciras et al., "CD4 Crosslinking Primes Resting CD4+ T Lymphocytes to Undergo Fas Dependent Apoptosis," XI International Conference of AIDS, Vancouver, B.C., Jul. 1996, Abstract No. We.A.140. |
Ameisen, Jean Claude, "Programmed cell death and AIDS: from hypothesis to experiment," Immunol. Today, 13(10):388-391 (1992). |
Upstate Biotechnology Inc. 1996 Catalog, pp. 186 and 187. |
Yonehara et al., "Involvement of apoptosis antigen Fas in clonal deletion of human thymocytes," International Immunology, 6(12):1849-1856, Dec. 1994. |
Tamura, Akiho, "Inhibition of Apoptosis and Augmentation of Lymphoproliferation in bcl-2 Transgenic Fas/Fas Ligand-Defective Mice," Cellular Immunology, 168:220-228 (1996). |
Katsikis et al., "Interleukin-1.beta. Converting Enzyme-like Protease Involvement in Fas-induced and Activation-induced Peripheral Blood T Cell Apoptosis in HIV Infection. TNF-related Apoptosis-inducing Ligand Can Mediate Activation-induced T Cell Death in HIV Infection," J. Exp. Med., 186(8):1365-1372 (1997). |
Katsikis et al., "HIV type 1 Tat protein enhances activation- but not Fas (CD95)-induced peripheral blood T cell apoptosis in healthy individuals," International Immunology, 9(6):835-841 (1997). |
Katsikis et al., "Activation-induced peripheral blood T cell apoptosis is Fas independent in HIV-infected individuals," International Immunology, 8:1311-1317 (1996). |
Badley et al., "Macrophage-dependent Apoptosis of CD4.sup.+ T Lymphocytes from HIV-infected Individuals Is Mediated by FasL and Tumor Necrosis Factor," J. Exp. Med., 185(1):55-64 (1997). |