Chams, et al., (1992) “Simple Assay To Screen for Inhibitors of Interaction Between the Human Immunodeficiency Virus Envelope Glycoprotein and Its Cellular Receptor, CD4” Antimicrobial Agents and Chemotherapy 36(2):262-272 (Exhibit 1). |
Dimitrov. D.S., et al., (1991) “Initial Stages of HIV-1 Envelope Glycoprotein-Mediated Cell Fusion Monitored by a New Assay Based on Redistribution of Fluorescent Dyes” AIDS Res. & Human Retroviruses (7(10):799-805 (Exhibit 2). |
Dragic, et al., (1993) “Different Requirement for membrane Fusion Mediated by the Envelopes of Human Immunodeficiency” Journal of Virology 67(2):2355-2359 (Exhibit 3). |
Fouchier, et al., (1994) “HIV-1 Macrophage Tropism Is Determined at Multiple Levels of the Viral Replication Cycle” Journal of Clinical Investigation 94:1806-1814 (Exhibit 4). |
Keller, P.M., et al., (1977) “A Fluorescence Enhancement Assay of Cell Fusion” J. Cell Sci. 28:167-177. |
Mitsuya, H., et al., (1985) “Protection of T Cells Against Infectivity and Cytopathic Effect of HTLV-III In Vitro, in Miwa, et al. Eds., Retroviruses in Human Lymphoma Leukemia” Japan Sci, Soc. Press, Tokyo/VNU Science Press, Utrecht pp. 277-288. |
Sandstrom, E.G. and Kaplan, J.C., (1987) “Antiviral Therapy in AIDS: Clinical Pharmacological Properties and Therapeutic Experience to Date” Drugs 34:372-390. |
Wanda, P.E., and Smith, J.D., (1983) “A General Method for Heterokaryon Detection Using Resonance Energy Transfer and a Fluorescence-activated Cell Sorter” J. Histochem. & Cytochem. 30(12):1297-1300. |
Benet et al., 1990, “Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, and Elimination,” in Goodman and Gilman's The Pharmacological Basis of Therapueutics, Gilman et al., eds., Pergamon Press, New York, pp. 3-32. |
Ebadi, M., 1998, “The Pharmacokinetic Basis of Therapeutics,” in CRC Desk Reference of Clinical Pharmacology, CRC Press LLC, Boca Raton, pp. 1-7. |
Allan, J., 1997, “Human Immunodeficiency Virus-Related Infections in Animal Model Systems,” in AIDS: Biology, Diagnosis, Treatment, and Prevention, fourth edition, De Vita, Jr., et al., eds., Lippincott-Raven Publishers, Philadelphia, pp. 15-27. |
Hirsch et al., 1997, “Antiretroviral Therapy,” in AIDS: Biology, Diagnosis, Treatment, and Prevention, fourth edition, De Vita, Jr., et al., eds., Lippincott-Raven Publishers, Philadelphia, pp. 495-508. |
Stein et al., 1993, “Immune-Based Therapeutics: Scientific Rationale and Promising Approaches to the Treatment of the Human Immunodeficiency Virus-Infected Individual,” Clin. Infect. Dis. 17:749-771. |
Sinangil et al., 1988, “Quantitative Measurement of Fusion Between Human Immunodeficiency Virus and Cultured Cells Using Membrane Fluorescence Dequenching,” Fed. Eur. Biochem. Soc. 239:88-92. |
Dimitrov et al., 1991, “Initial Stages of HIV-1 Envelope Glycoprotein-Mediated Cell Fusion Monitored bya New Assay Based on Redistribution of Fluorescent Dyes,” AIDS Res. Human Retro. 7:799-805. |
Chams et al., 1992, “Simple Assay to Screen for Inhibitors of Interaction Between the Human Immunodeficiency Virus Envelope Glycoprotein and It's Cellular Receptor, CD4,” Antimicrob. Agents Chem. 36:267-272. |
Szabo et al., 1992, “CD4 Changes Conformation Upon Ligand Binding,” J. Immunol. 149:3596-3604. |
O'Brien et al., 1990, “HIV-1 Tropism for Mononuclear Phagocytes can be Determined by Regions of gp120 Outside of the CD4-binding Domain,” Nature 348:69-73. |
Crowe, S.M., et al., 1992, “Human immunodeficiency virus-infected monocyte-derived macrophages express surface gp120 and fuse with CD4 lymphoid cells in vitro: a possible mechanism of T lymphocyte depletion in vivo.”, ; Immunology and Immunopathology. vol. 65, No. 2, pp. 143-151. |
Schmidtmayerova, H., et al., 1993, “Characterization of HIV1-PAR a macrophage-tropic strain: cell tropism, virus/cell entry and nucleotide sequence of the envelope glycoprotein.”, Research in Virology. vol. 144, No. 1, pp. 21-26. |