Claims
- 1. An isolated polynucleotide comprising a member selected from the group consisting of:
(a) a polynucleotide encoding the polypeptide as set forth in SEQ ID NO: 2; (b) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a); and (c) a polynucleotide fragment of the polynucleotide of (a) or (b).
- 2. The polynucleotide of claim 1 encoding the polypeptide as set forth in SEQ ID NO: 2.
- 3. The polynucleotide of claim 1 wherein the polynucleotide is DNA.
- 4. An isolated polynucleotide comprising a member selected from the group consisting of:
(a) a polynucleotide encoding a mature polypeptide encoded by the DNA contained in ATCC Deposit No. 75701; (b) a polynucleotide encoding the polypeptide expressed by the DNA contained in ATCC Deposit No. 75701; (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b); and (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
- 5. A vector containing the DNA of claim 2.
- 6. A host cell transformed or transfected with the vector of claim 11.
- 7. A process for producing a polypeptide comprising: expressing from the host cell of claim 12 the polypeptide encoded by said DNA.
- 8. A process for producing cells capable of expressing a polypeptide comprising transforming or transfecting the cells with the vector of claim 11.
- 9. A receptor polypeptide comprising a member selected from the group consisting of:
(i) a polypeptide having the deduced amino acid sequence of SEQ ID NO: 2 and fragments, analogs and derivatives thereof; and (ii) a polypeptide encoded by the cDNA of ATCC Deposit No. 75701 and fragments, analogs and derivatives of said polypeptide.
- 10. An antibody against the polypeptide of claim 15.
- 11. A compound which activates the polypeptide of claim 15.
- 12. A compound which inhibits activation the polypeptide of claim 15.
- 13. A method for the treatment of a patient having need to activate a G-protein coupled receptor comprising: administering to the patient a therapeutically effective amount of the compound of claim 18.
- 14. A method for the treatment of a patient having need to inhibit a G-protein coupled receptor comprising: administering to the patient a therapeutically effective amount of the compound of claim 19.
- 15. The method of claim 20 wherein said compound is a polypeptide and a therapeutically effective amount of the compound is administered by providing to the patient DNA encoding said agonist and expressing said agonist in vivo.
- 16. The method of claim 21 wherein said compound is a polypeptide and a therapeutically effective amount of the compound is administered by providing to the patient DNA encoding said antagonist and expressing said antagonist in vivo.
- 17. A method for identifying compounds which bind to and activate or inhibit the receptor polypeptide of claim 15 comprising:
contacting a cell expressing on the surface thereof the receptor polypeptide, said receptor being associated with a second component capable of providing a detectable signal in response to the binding of a compound to said receptor polypeptide, with a compound under conditions sufficient to permit binding of the compound to the receptor polypeptide; and identifying if the compound is an agonist or antagonist by detecting the presence or absence of the signal produced by said second component.
- 18. A process for diagnosing a disease or a susceptibility to a disease related to an under-expression of the polypeptide of claim 15 comprising:
determining a mutation in the nucleic acid sequence encoding said polypeptide.
- 19. The polypeptide of claim 15 wherein the polypeptide is a soluble fragment of the polypeptide and is capable of binding a ligand for the receptor.
- 20. A diagnostic process comprising:
analyzing for the presence of the polypeptide of claim 33 in a sample derived from a host.
Parent Case Info
[0001] This application is a continuation-in-part of PCT/US94/13296 filed Nov. 18, 1994.
Continuations (1)
|
Number |
Date |
Country |
Parent |
08461989 |
Jun 1995 |
US |
Child |
09985694 |
Nov 2001 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
PCT/US94/13296 |
Nov 1994 |
US |
Child |
08461989 |
Jun 1995 |
US |