Claims
- 1. A peptide of the formula I ##STR5## in which X is C.sub.2 -C.sub.8 -alkanoyl;
- A is D-Nal (2), D-Phe or D-Trp, where the aromatic ring can optionally be substituted by one or two identical or different radicals selected from the group consisting of bromine, chlorine, fluorine, nitro, C.sub.1 -C.sub.4 -alkyl and C.sub.1 -C.sub.4 -alkoxy;
- B is D-Phe which can optionally be substituted by one or two identical or different radicals selected from the group consisting of bromine, chlorine, fluorine, nitro, C.sub.1 -C.sub.4 -alkyl, and C.sub.1 -C.sub.4 -alkoxy;
- C is D-Pal (3), D-Phe, or D-Trp, wherein the aromatic ring of D-Phe and D-Trp can optionally be substituted by one or two identical or different radicals selected from the group consisting of bromine, chlorine, fluorine, nitro, C.sub.1 -C.sub.4 -alkyl, and C.sub.1 -C.sub.4 -alkoxy;
- D is Tyr or His;
- E is D-Ser(R.sup.1);
- F is Leu, Trp or Phe;
- G is L-Ser(R.sup.1) having a non-basic charge;
- H is Gly-NH.sub.2, D-Ala-NH.sub.2, or Azagly-NH.sub.2 ;
- R.sup.1 is a glycosyl radical; or the physiologically tolerated salt thereof.
- 2. A peptide of the formula I as claimed in claim 1, in which
- X is acetyl;
- A is D-Nal(2);
- B is D-Phe(p-Cl);
- C is D-Pal(3) or D-Trp;
- D is Tyr;
- E is D-Ser(R.sup.1);
- F is Leu;
- G is L-Ser(R.sup.1) having a non-basic charge; H is D-Ala-NH.sub.2 or Azagly-NH.sub.2, and the physiologically acceptable salt thereof.
- 3. A pharmaceutical composition comprising a peptide of the formula I as claimed in claim 1 or the physiologically acceptable salt thereof and a pharmaceutically acceptable carrier.
- 4. A method of lowering plasma gonadotropin, testosterone, and estrogen in a mammal comprising administering to said mammal an effective amount of a peptide of the formula I as claimed in claim 1 or a pharmaceutically acceptable salt thereof.
Priority Claims (1)
Number |
Date |
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Kind |
40 24 779.1 |
Aug 1990 |
DEX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/739,233, filed Aug. 1, 1991, now abandoned.
US Referenced Citations (6)
Foreign Referenced Citations (3)
Number |
Date |
Country |
7945987 |
Jan 1990 |
AUX |
0263521 |
Apr 1988 |
EPX |
2218102 |
Nov 1989 |
GBX |
Non-Patent Literature Citations (3)
Entry |
Folkers et al, Biochem and Biophys Res. Comm. vol. 123, No. 3, pp. 1221-1226, 1984. |
Ljungqvist et al., "Design, Synthesis and Bioassays of Antagonists of LHRH Which Have High Antiovulatory Activity and Release Negligible Histamine", Biochemical and Biophysical Research Communications, 148, 849-856 (1987). |
European Search Report. |
Continuations (1)
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Number |
Date |
Country |
Parent |
739233 |
Aug 1991 |
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