Claims
- 1. An isolated polynucleotide selected from the group consisting of:
(a) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1; (b) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 152 to nucleotide 3730; (c) a polynucleotide comprising the nucleotide sequence of SEQ ID NO:1 from nucleotide 152 to nucleotide 3640; (d) a polynucleotide comprising the nucleotide sequence of the full-length protein coding sequence of clone GP-122 deposited under accession number ATCC 98622; (e) a polynucleotide encoding the full-length protein encoded by the cDNA insert of clone GPI-122 deposited under accession number ATCC 98622; (f) a polynucleotide encoding a protein comprising the amino acid sequence of SEQ ID NO:2; (g) a polynucleotide encoding a protein comprising a fragment of the amino acid sequence of SEQ ID NO:2, the fragment comprising eight contiguous amino acids of SEQ ID NO:2; (h) a polynucleotide that hybridizes under conditions at least as stringent as 4×at 65 degrees C., or 4×at 42 degrees C. with 50% formamide, to any one of the polynucleotides specified in (a)-(g); and (i) a polynucleotide that hybridizes under conditions at least as stringent as 4×at 50 degrees C., or 6×at 40 degrees C. with 50% formamide, to any one of the polynucleotides specified in (a)-(g), and that has a length that is at least 25% of the length of SEQ ID NO:1.
- 2. The polynucleotide of claim 1 wherein said polynucleotide is operably linked to at least one expression control sequence.
- 3. A host cell transformed with the polynucleotide of claim 2.
- 4. The host cell of claim 3, wherein said cell is a mammalian cell.
- 5. A process for producing a protein encoded by the polynucleotide of claim 2, which process comprises:
(a) growing a culture of the host cell of claim 3 in a suitable culture medium; and (b) purifying said protein from the culture.
- 6. A protein produced according to the process of claim 5.
- 7. An isolated polynucleotide encoding the protein of claim 6.
- 8. The polynucleotide of claim 7, wherein the polynucleotide comprises the cDNA insert of clone GPI-122 deposited under accession number ATCC 98622.
- 9. A protein comprising an amino acid sequence selected from the group consisting of:
(a) the amino acid sequence of SEQ ID NO:2; (b) the amino acid sequence of SEQ ID NO:2 from amino acid 1 to amino acid 1163; (c) a fragment of the amino acid sequence of SEQ ID NO:2, the fragment comprising eight contiguous amino acids of SEQ ID NO:2; and (d) the amino acid sequence encoded by the cDNA insert of clone GPI-122 deposited under accession number ATCC 98622; the protein being substantially free from other mammalian proteins.
- 10. The protein of claim 9, wherein said protein comprises the amino acid sequence of SEQ ID NO:2.
- 11. The protein of claim 9, wherein said protein comprises the amino acid sequence of SEQ ID NO:2 from amino acid 1 to amino acid 1163.
- 12. A composition comprising the protein of claim 9 and a pharmaceutically acceptable carrier.
- 13. The polynucleotide of claim 1, wherein the polynucleotide comprises the nucleotide sequence of SEQ ID NO:1.
- 14. The polynucleotide of claim 1, wherein the polynucleotide comprises the nucleotide sequence of SEQ ID NO:1 from nucleotide 152 to nucleotide 3730.
- 15. The polynucleotide of claim 1, wherein the polynucleotide comprises the nucleotide sequence of SEQ ID NO:1 from nucleotide 152 to nucleotide 3640.
- 16. The polynucleotide of claim 1, wherein the polynucleotide comprises the nucleotide sequence of the full-length protein coding sequence of clone GPI-122 deposited under accession number ATCC 98622.
- 17. The polynucleotide of claim 1, wherein the polynucleotide encodes the full-length protein encoded by the cDNA insert of clone GPI-122 deposited under accession number ATCC 98622.
- 18. The polynucleotide of claim 1, wherein the polynucleotide comprises the nucleotide sequence of a mature protein coding sequence of GPI-122 deposited under accession number ATCC 98622.
- 19. The polynucleotide of claim 1, wherein the polynucleotide encodes a mature protein encoded by the cDNA insert of clone GPI-122 deposited under accession number ATCC 98622.
- 20. The polynucleotide of claim 1, wherein the polynucleotide encodes a protein comprising the amino acid sequence of SEQ ID NO:2.
- 21. The polynucleotide of claim 1, wherein the polynucleotide encodes a protein comprising a fragment of the amino acid sequence of SEQ ID NO:2, the fragment comprising eight contiguous amino acids of SEQ ID NO:2.
- 22. The protein of claim 9, wherein the protein comprises a fragment of the amino acid sequence of SEQ ID NO:2, the fragment comprising eight contiguous amino acids of SEQ ID NO:2.
- 23. The protein of claim 9, wherein the protein comprises the amino acid sequence encoded by the cDNA insert of clone GPI-122 deposited under accession number ATCC 98622.
- 24. An antibody that reacts specifically with the protein of claim 9.
- 25. The antibody of claim 24, wherein the antibody is a monoclonal antibody.
- 26. The antibody of claim 24, wherein the antibody is a human antibody.
Parent Case Info
[0001] This application is a continuation-in-part of application Ser. No. 60/XXX,XXX (converted to a provisional application from non-provisional application Ser. No. 09/049,652), filed Mar. 27, 1998, which is incorporated by reference herein.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60145745 |
Mar 1998 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
09277837 |
Mar 1999 |
US |
Child |
10040919 |
Jan 2002 |
US |