Claims
- 1. A compound of the formula: ##STR2## wherein Z is CO,
- Y is O,
- X is N, and
- R is selected from the group consisting of C.sub.2-6 fluoralkyl, C.sub.1-6 fluorinated alkoxy, and C.sub.1-4 halogenated alkyl with an attached phenyl.
- 2. A process for the inhibition of elastase, chymotrypsin and serine proteases which cleave peptide bonds in peptides and protein between two specific amino acids --AA1--AA2-- where AA1 is Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr, or Val and AA2 is Ala, Arg, Asn, Asp, Cys, Glu, Gln, Gly, His, Ile, Leu, Lys, Met, Phe, Pro, Ser, Thr, Tyr, or Val, comprising the step of adding to a medium containing the protease an effective amount of an inhibitor having the following structure: ##STR3## wherein: Z is CO,
- Y is O,
- X is N, and
- R is selected from the group consisting of C.sub.1-6 alkyl, C.sub.1-4 alkyl containing a phenyl, and C.sub.1-6 fluoroalkyl.
- 3. A method for treating emphysema in mammalian species, comprising the step of administering to said mammalian species a therapeutically effective amount of a compound having the following structure: ##STR4## wherein Z is CO,
- Y is O,
- X is N, and
- R is selected from the group consisting of C.sub.1-6 alkyl, C.sub.1-4 alkyl containing a phenyl, and C.sub.1-6 fluoroalkyl.
Parent Case Info
This is a divisional of co-pending application Ser. No. 492,825 filed on May 9, 1983, now U.S. Pat. No. 4,585,793.
US Referenced Citations (4)
Number |
Name |
Date |
Kind |
3772304 |
Grethe et al. |
Nov 1973 |
|
4465687 |
Doherty et al. |
Aug 1984 |
|
4469885 |
Mueller et al. |
Sep 1984 |
|
4493839 |
Doherty et al. |
Jan 1985 |
|
Non-Patent Literature Citations (1)
Entry |
Kleinerman et al., Am. Rev. Respir. Dis., 1981, pp. 714-717. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
492825 |
May 1983 |
|