Claims
- 1. A human immunodeficiency virus protease inhibiting compound of the formula: ##STR23## or a pharmaceutically-acceptable acid-addition salt thereof, wherein
- R' is selected from a group consisting of hydrogen, hydroxyl, and a protected hydroxyl;
- R" is selected from a group consisting of an amino protecting group, and U--V,
- wherein U is an oligopeptide containing a sequence of up to five amino acids and V is an N-terminating group; and
- A is represented by the following structure: ##STR24## wherein R.sup.5 is selected from the group consisting of C.sub.1 -C.sub.3 alkoxy, a protected amino group, and O--Q, wherein O is an oligopeptide containing a sequence of up to four amino acid residues and Q is a C-terminating group.
- 2. The compound according to claim 1, wherein R' is hydrogen.
- 3. The compound according to claim 1, wherein R" is an amino protecting group selected from Ac, Bz, Boc, Cbz and Tba.
- 4. The compound according to claim 1, wherein R" is U--V.
- 5. The compound according to claim 4, wherein U is a sequence selected from Asn, His, Phe, Val, Ile-Thr, Ala-Ala, Phe-Phe, Val-Val, His-Phe, Ala-Ala-Ser, Asn-Leu-Ser, Asn-Gln-Ser-Val (SEQ ID NO 13), and His-Phe-Pro-His (SEQ ID NO 14).
- 6. The compound according to claim 4, wherein V is an N-terminating group selected from Ac, Boc, Cbz, Noa and Qc.
- 7. The compound according to claim 1, wherein R.sup.5 is t-butoxy.
- 8. The compound according to claim 1, wherein R.sup.5 is O--Q.
- 9. The compound according to claim 1, wherein R.sup.5 is a sequence selected from Ile-Val and Val-Val.
- 10. The compound according to claim 8, wherein Q is amino or C.sub.1 -C.sub.3 alkoxy.
Parent Case Info
This application is a CIP of U.S. Ser. No. 08/335,039, filed Feb. 16, 1995 now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5142056 |
Kempe et al. |
Aug 1992 |
|
Non-Patent Literature Citations (1)
Entry |
Rich et al., "Effect of Hydroxl in Hydroxethylamine Dipepetide Isosteres On HIV Proteasew Inhibition"S. Med. Chem., (1991) v.34 pp. 1222-1225. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
335039 |
Feb 1995 |
|