Claims
- 1. An isolated polynucleotide comprising a member selected from the group consisting of:
(a) a polynucleotide encoding the polypeptide comprising amino acid −24 to amino acid 72 as set forth in SEQ ID NO:2; (b) a polynucleotide encoding the polypeptide comprising amino acid 1 to amino acid 72 as set forth in SEQ ID NO:2 (c) a polynucleotide encoding the polypeptide comprising amino acid −23 to amino acid 75 as set forth in SEQ ID NO:4; (d) a polynucleotide encoding the polypeptide comprising amino acid 1 to amino acid 75 as set forth in SEQ ID NO:4; (e) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a), (b), (c) or (d); and (f) a polynucleotide fragment of the polynucleotide of (a), (b), (c), (d) or (e).
- 2. The polynucleotide of claim 1 wherein the polynucleotide is DNA.
- 3. The polynucleotide of claim 2 which encodes a member selected from the group consisting of:
(a) the polypeptide comprising amino acid 1 to 72 of SEQ ID NO:2; and (b) the polypeptide comprising amino acid 1 to 75 of SEQ ID NO:4.
- 4. An isolated polynucleotide comprising a member selected from the group consisting of:
(a) a polynucleotide which encodes a mature polypeptide having the amino acid sequence expressed by the DNA contained in ATCC Deposit No. 75848; (b) a polynucleotide which encodes a mature polypeptide having the amino acid sequence expressed by the DNA contained in ATCC Deposit No. 75849; (c) a polynucleotide capable of hybridizing to and which is at least 70% identical to the polynucleotide of (a) or (b); and (d) a polynucleotide fragment of the polynucleotide of (a), (b) or (c).
- 5. The polynucleotide of claim 1 comprising the sequence as set forth in SEQ ID No. 1 from nucleotide 73 to nucleotide 291.
- 6. The polynucleotide of claim 1 comprising the sequence as set forth in SEQ ID No. 1 from nucleotide 70 to nucleotide 297.
- 7. A vector containing the DNA of claim 2.
- 8. A host cell genetically engineered with the vector of claim 7.
- 9. A process for producing a polypeptide comprising: expressing from the host cell of claim 8 the polypeptide encoded by said DNA.
- 10. A process for producing cells capable of expressing a polypeptide comprising genetically engineered cells with the vector of claim 7.
- 11. A polypeptide encoded by the polynucleotide of claim 1 comprising a member selected from the group consisting of; (i) a mature polypeptide having the deduced amino acid sequence of SEQ ID NO:2 and fragments, analogs and derivatives thereof; (ii) a mature polypeptide encoded by the cDNA of ATCC Deposit No. 75848 and fragments, analogs and derivatives of said polypeptide; (iii) a mature polypeptide having the deduced amino acid sequence of SEQ ID NO:4 and fragments, analogs and derivatives thereof; and (iv) a mature polypeptide encoded by the cDNA of ATCC Deposit No. 75849 and fragments, analogs and derivatives of said polypeptide.
- 12. The polypeptide of claim 11 wherein the polypeptide comprises amino acid 1 to amino acid 72 of SEQ ID NO:2.
- 13. A compound which inhibits activation of the receptor for the polypeptide of claim 11.
- 14. A compound which activates the receptor for the polypeptide of claim 11.
- 15. A method for the treatment of a patient having need of a polypeptide of claim 11 comprising: administering to the patient a therapeutically effective amount of the polypeptide.
- 16. The method of claim 15 wherein said therapeutically effective amount of the polypeptide is administered by providing to the patient DNA encoding said polypeptide and expressing said polypeptide in vivo.
- 17. A method for the treatment of a patient having need to inhibit a chemokine polypeptide comprising: administering to the patient a therapeutically effective amount of the compound of claim 13.
- 18. A process for diagnosing a disease or a susceptibility to a disease related to an under-expression of the polypeptide of claim 11 comprising:
determining a mutation in a nucleic acid sequence encoding said polypeptide.
- 19. A diagnostic process comprising:
analyzing for the presence of the polypeptide of claim 11 in a sample derived from a host.
- 20. A method for identifying agonist or antagonist compounds to the polypeptide of claim 11 comprising:
contacting a cell expressing on the surface thereof a receptor for the polypeptide, said receptor being associated with a second component capable of providing a detectable signal in response to the binding of a compound to said receptor, with an analytically detectable compound under conditions to permit binding to the receptor; detecting the absence or presence of a signal generated from the interaction of the compound with the receptor.
CROSS REFERENCE TO RELATED APPLICATIONS
[0001] This Application is a divisional of U.S. application Ser. No. 10/164,621, filed Jun. 10, 2002, which is a divisional of U.S. application Ser. No. 09/261,201, filed Mar. 3, 1999 (now U.S. Pat. No. 6,458,349, issued Oct. 1, 2002), which is a divisional of U.S. application Ser. No. 08/458,355, filed Jun. 2, 1995 (now U.S. Pat. No. 5,981,230, issued Nov. 9, 1999), which is a continuation-in-part of International Application No. PCT/US94/09484, filed Aug. 23, 1994, each of which is hereby incorporated by reference in its entirety.
Divisions (3)
|
Number |
Date |
Country |
Parent |
10164621 |
Jun 2002 |
US |
Child |
10893995 |
Jul 2004 |
US |
Parent |
09261201 |
Mar 1999 |
US |
Child |
10164621 |
Jun 2002 |
US |
Parent |
08458355 |
Jun 1995 |
US |
Child |
09261201 |
Mar 1999 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
PCT/US94/09484 |
Aug 1994 |
US |
Child |
08458355 |
Jun 1995 |
US |