This application is a continuation-in-part of U.S. application Ser. No. 07/764,309, filed Sep. 20, 1991, now abandoned.
This invention was made with government support under grant CA48718 awarded by the National Institutes of Health. The government has certain rights in the invention.
Entry |
---|
Nugent et al. (1991) J. Cell Science 99:669-674. |
Koff, A. et al.Cell, vol. 66, pp. 1212-1228, Sep. 20, 1991. |
Arion, D., Meijer, L., Brizuela, L., and Beach, D. (1988). cdc2 is a component of the M phase-specific histone H1 Kinase: evidence for identity with MPF. Cell 55, 371-378. |
Cross, F. (1988). DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae Mol. Cell. Biol. 8, 4675-4684. |
Cross, F. (1990). Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles Start-1 arrest and is independent of the mating-pheromone signalling pathway. Molec. Cell. Biol. 10, 6482-6490. |
Draetta, G., and Beach, D. (1988). Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell, 17-26. |
Draetta, G., Luca, F., Westendorf, J., Brizuela, L. Ruderman, J., and Beach, D. (1989). cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell 56, 829-838. |
Dunphy, W. G., Brizuela, L., Beach, D., and Newport, J. (1988). The Xenopus cdc 2 protein is a component of MPF, a cytoplasmic regulator of mitosis. Cell 54, 423-431. |
D'Urso, G., Marraccino, R. L., Marshak, D. R., and Roberts, J. M. (1990). Cell cycle control of DNA replication by a homologue from human cells of the p34.sup.cdc2 protein kinase. Science 250, 786-791. |
Evans, T., Rosenthal, E. T., Youngblom, J., Disten, D., and Hunt, T. (1983). Cyclin: a protein specified by maternal mRNA in sea urchin egg that is destroyed at each cleavage division. Cell 33, 389-296. |
Furakawa, Y., Piwnica-Worms, H., Ernst, T. J., Kanakura, Y., and Griffin, J. D. (1990). Cdc2 gene expression at the G.sub.1 to S transition in human T lymphocytes. Scinece 250, 805-808. |
Gautier, J., Norbury, C., Lohka, M., Nurse, P., and Maller J. L. (1988) Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2.sup.+. Cell 54, 433-439. |
Gautier, J., Minshull, J., Lohka, M., Glotzer, M., Hunt, T., and Maller, J. L. (1990). Cyckin is a component of maturation-promoting factor from Xenopus. Cell 60, 487-494. |
Hadwiger, J. A., Wittenberg, C., Richardson, H. E., Lopes, M.dB., and Reed, S. I. (1989). A family of cyclin homologs that control the G.sub.1 phase in yeast. Proc. Natl. Acad. Sci. USA 86, 6255-6259. |
Hunt, T. (1989). Maturation promoting factor, cyclin and the control of M-phase. Curr. Opin. Cell Biol. 1, 268-274. |
Labbe, J. C., Lee, M. G., Nurse, P., Picard. A., and Doree, M. (1988). Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle gene cdc2.Nature 335, 251-254. |
Labbe, J. C., Capony, J. P., Caput, D., Cavadore, J. C., Derancourt, J., Kaghad, M., Lelias, J. M., Picard, A., and Doree, M. (1989a). MPF from starfish oocytes at first meiotic metaphase is a heterodimer containing one molecule of cdc2 and oe molecule of cyclin B. EMBO J. 8, 3053-3058. |
Labbe, J. C., Picard, A., Peaucellier, G., Cavadore, J. C., Nurse, P., and Doree, M. (1989b). Purification of NPF from starfish: identification as the H1 histone kinase p34.sup.cdc2 and a possible mechanism for its periodic activation. Cell 57, 253-263. |
Lee, M. G. and Nurse, P. (1987). Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2. Nature 327, 31-35. |
Meijer, I., Arion, D., Golsteyn, R., Pines, J., Brizuela, L., Hunt, T., and Beach, D. (1989). Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase. EMBO J. 8, 2275-2282. |
Minshull, J., Blow, J. J., and Hunt, T. (1989). Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis. Cell 56, 947-956. |
Murray, A. W., and Kirschner, M. W. (1989). Cyclin synthesis drives the early embryonic cell cycle. Nature 339, 275-280. |
Nash, R., Tokiwa, G., Anand, S., Erickson, K., and Futcher, A. B. (1988). The WHI gene of Saccharomyces cerivisiae tethers cell division to cell size and is a cyclin homolog. EMBO J. 7, 4335-4346. |
Nurse, P. (1990). Universal control mechanism regulating onset of M-phase. Nature 344, 503-508. |
Nurse, P. and Bisset, Y. (1981). Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast. Nature 292, 558-560. |
Pardee, A. B. (1989). G1 events and regulatin of cell proliferation. Science 246, 603-608. |
Piggot, J. R., Rai, R, and Carter, B. L. A. (1982). A bifunctional gene product involved in two phases of the yeast cell cycle. Nature 298, 391-393. |
Pines J., and Hunter, T. (1989). Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34.sup.cdc2. Cell 58, 833-846. |
Rao, P. N., and Johnson, R. T. (1970. Mammalian cell fusion: studies on the regulation of DNA synthesis and mitosis. Nature 225, 159-164. |
Reed, S. I., and Wittenberg, C. (1990). Mitotic role for the Cdc28 protein kinase of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 87, 5697-5701. |
Riabowol, K., Draetta, G., Brizuela, L., Vandre, D., and Beach, D. (1989). The cdc2 kinase is a nuclear portein that is essential for mitosis in mammalian cells. Cell 57, 393-401. |
Richardson, H. E., Wittenberg, C., Cross, F., and Reeed, S. I. (1989). An essential G1 function for cyclin-like proteins in yeast. Cell 59, 1127-1133. |
Rosenthal, E. T., Hunt, T., and Ruderman, J. V. (1980). Selective translation of mRNA controls the pattern of protein synthesis during early development of the surf clam, Spisula solidissima. Cell 20, 487-494. |
Soloman, M., Glotzer, M., Lee, T. H., Phillippe, M., and Kirschner, M. W. (1990). Cyclin activation of p34.sup.cdc2. Cell 63, 1013-1024. |
Sudbery, P. E., Goodey, A. R., and Carter, B. L. (1980). Genes which control cell proliferation in the yeast Saccharomyces cerevisiae. Nature (London) 288, 401-404. |
Swenson, K. I., Farrell, K. M., and Ruderman, J. V. (1986). The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes. Cell 47, 861-870. |
Wittenberg, C., and Reed, S. I. (1989). Conservation of function and regulation within the Cdc28/cdc2 protein kinase family: Characterization of the human Cdc2HS protein kinase in Saccharomyces cerevisiae. Mol. Cell Biol. 4064-4068. |
Wittenberg, C., Sugimoto, K., and Reed, S. I. (1990). G1-specific cyclins of S. cerevisiae: cell cycle periodicity, reglation by mating pheromone, and asociation with the p34.sup.CDC28 protein kinase. Cell 62, 225-237. |
Zetterberg, A. (1990). Control of mammalian cell proliferation. Curr. Opin. Cell Biol. 2, 296-300. |
Zetterberg, A., and Larson, O. (1985). Kinetic analysis of regulatory events in G1 leading to proliferation of quiescence of Swiss 3T3 cells. Proc. Natl. Acad. Sci. USA 82, 5365-5369. |
Nasmyth, K. A. (1990). FAR-reaching discoveries about the regulation of START. Cell 63, 1117-1120. |
Roberts, J. (1991). Assembly of cyclin/CDC2 complexes during the G1 phase of the cell cycle and their role in activating DNA synthesis. Cold Spring Harbor Laboratory, p. 126. |
Beach, D., Durkacz, B., and Nurse, P. (1982). Functionally homologous cell cycle control genes in fission yeast and budding yeast. Nature 300, 706-709. |
Blow, J. J., and Nurse, P. (1990). A cdc2-like protein is involved in the initation of DNA replication in Xenopus egg extracts. Cell 62, 855-862. |
Boeke, J. D., LaCroute, F., and Fink, G. R. (1984). A positive selection for mutants lacking 5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol. Gen. Genet. 197, 345-346. |
Booher, R., and Beach, D. (1987). Interaction between cdc13.sup.+ and cdc2 in the control of mitosis in fission yeast; dissociation of the G.sub.1 and G.sub.2 roles of the cdc2.sup.30 protein kinase. EMBO J. 6, 3441-3447. |
Booher, R. N., Alfa, C. E., Hyams, J. S., and Beach, D. H. (1989). The fission yeast cdc2/cdc13/sucl protein kinase: regulation of catlytic activity and nuclear localization. Cell 58, 485-497. |
Broek, D., Bartlett, R., Crawford, K., and Nurse, P. (1990). Involvement of p34.sup.cdc2 in establishing the dependency of S phase on mitosis. Nature 349, 388-393. |
Colicelli, J., Birchmeier, C., Michaeli, T., O'Neill, K., Riggs, M., and Wigler, M. (1989). Isolation and characterization of a mammalian gene encoding in high-affinity cAMP phosphodiesterase. Proc. Natl. Acad. Sci. USA 86, 3599-3603. |
Cross, F. R., and Tinkelenberg, A. H. (1991). A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle. Cell 65, 875-883. |
Ghiara, J. B., Richardson, H. E., Sugimoto, K., Henze, M., Lew, D. J., Wittenberg, C., and Reed, S. I. (1991). A cyclin B homolog in S. cerevisiae: chronic activation of the CDC28 protein kinase by cyclin prevents exit from mitosis. Cell 65, 163-174. |
Giordano, A., Whyte, P., Harlow, E., Franza, Jr., B. R., Beach, D., and Draetta, G. (1989). A 60 kDa cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell 58, 981-990. |
Glotzer, M., Murray, A. W., and Kirschner, M. W. (1991). Cyclin is degraded by the ubiquitin pathway. Nature 349, 132-138. |
Gould, K. L., and Nurse, P. (1989). Tyrosine phosphorylation of the fission yeast cdc2.sup.+ protein kinase regulates entry into mitosis. Nature 342, 39-45. |
Hagan, I., Hayles, J., and Nurse, P. (1988). Cloning and sequencing of the cyclin related cdc13 gene and a cytological study of its role in fission yeast mitosis. J. Cell Sci. 91, 587-595. |
Hartwell, L. J., Mortimer, R. K., Culotti, J., and Culotti, M. (1973). Genetic control of the cell division cycle in yeast. V. Genetic analysis of cdc mutants. Genetics 74, 267-286. |
Hartwell, L. H., Culotti, J., Pringle, J. R., and Reid, B. J. (1974). Genetic control of the cell division cycle in yeast. Science 183, 46-51. |
Hindley, J., and Phear, G. A. (1984). Sequence of the cell division gene cdc2 from Schizosaccharomyces pombe: pattern of splicing and homology to protein kinases. Gene 31, 129-134. |
Krek, W., and Nigg, E. A. (1991). Differential phosphorylation of vertebrate p34.sup.cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. EMBO J. 10, 305-316. |
Lee, M. G., Norbury, C. J., Spurr, N. K., and Nurse, P. (1988). Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein. Nature 333, 676-678. |
Lew, D. J., Dulic, V., Reed, S. I. (1991). Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 66: 1197-1206. |
Lorincz, A. T., and Reed, S. I. (1984). Primary structure homology between the product of the yeast cell cycle control gene CDC28 and vetrebrate oncogenes. Nature 307, 183-185. |
Marshak, D. R., Vandenberg, M. T., Bae, Y. S., and Yu, I. J. (1991). Characterization of synthetic peptide substrates for p34 cdc2 protein kinase. J. Cell. Biochem. 45, 391-400. |
Matsushime, H., Roussel, M. F., Ashumun, R. A., and Sherr, C. J. (1991). Colony -stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65, 701-713. |
Mendenhall, M. D., Jones, C. A., and Reed, S. I. (1987). Dual regulation of the yeast CDC28-p40 protein kinase complex: cell cycle, pheromone, and nutrient limitation effects. Cell 50, 927-935. |
Moreneo, S., Hayles, J., and Nurse, P. (1989). Regulation of p34.sup.cdc2 protein kinase during mitosis. Cell 58, 361-372. |
Motokura, T., Bloom, T., Kim, H. G., Juppner, H., Ruderman, J. V., Kronenberg, H. M., and Arnold, A. (1991). A BCL1-linked candidate oncogene which is rearranged in parathyroid tumors encodes a novel cyclin. Nature 350, 512-515. |
Pardee, A. B. (1974). A restriction point for control of normal animal cell proliferation. Proc. Natl. Acad. Sci. USA 71, 1286-1290. |
Paris, S., Le Guellec, R., Couturier, A., Le Guellec, K., Omilli, F., Camonis, J., MacNeill, S., and Philippe, M. (1991). Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2. Proc. Natl. Acad. Sci. USA 88, 1029-1043. |
Pines, J., and Hunter, T. (1990). Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B. Nature 346, 760-763. |
Roberts, J. M., and D'Urso, G. (1988). An origin unwinding activity regulates initiation of DNA replication during mammalian cell cycle. Science 241, 1486-1489. |
Rogers, S., Wells, R., and Rechsteiner, M. (1986). Amino acid sequences common to rapidly degrated proteins: the PEST hypothesis. Science 234, 364-368. |
Schiestl, R. H., and Gietz, R. D. (1989). High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier. Current Genetics 16, 339-346. |
Simanis, V., and Nurse, P. (1986). The cell cycle control gene cdc2.sup.+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation. Cell 45, 261-268. |
Soloman, M., Booher, R., Kirschner, M., and Beach, D. (1988). Cyclin in fission yeast. Cell 54, 738-739. |
Surana, U., Robitsch, H., Price, C., Schuster, T., Fitch, I., Futcher, A. B., and Hasmyth, K. (1991). The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 65, 145-161. |
Th'ng, J. P. H., Wright, P. S., Hamaguchi, J., Lee, M. G., Norbury, C. J., Nurse, P., and Bradbury, E. M. (1990). The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product. Cell 63, 313-324. |
Wang, J., Chenivesse, X., Henglein, B., and Brechot, C. (1990). Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 343, 555-557. |
Xiong, Y., Connolly, T., Futcher, B., and Beach, D. (1991). Human D-type cyclin. Cell 65, 691-699. |
Murray, A. W. and M. W. Kirschner (1989). Dominoes and clocks: the union of two views of the cell cycle. Science 246, 614-621. |
Amon, A., Surana, U., Muraoff, I., and Nasmyth (1992) Regulation of p34 CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae. Nature 355:368-371. |
Bandara, L., Adamczewski, J., Hunter, T., and LaThanghe, N. (1991). Cyclin A and the retinoblastoma gene product complex with a common transcription factor. Nature 352:249-251. |
Baserga, R. (1985). The biology of cell reproduction. Cambridge, Mass.: Harvard University Press. |
Brooks, R. (1977). Continuous protein synthesis is required to maintain the probability of entry into S phase. Cell 12:311-317. |
Cantley, L., Auger, K., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R., and Soltoff, S. (1991). Oncogenes and signal transduction. Cell 64:281-302. |
Chang. F., and Herskowitz, I. (1990). Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2. Cell 63:999-1011. |
Chao, M. (1992). Growth factor signalling: where is the specificity? Cell 68:995-997. |
Cross, F., Roberts, J., and Weintraub, J. (1989). Simple and comples cell cycles . Ann. Rev. Cell Biol. 5:341-395. |
Dirick, L., and Nasmyth, K. (1991). Positive feedback in the activation of G1 cyclins in yeast. Nature 351:754-757. |
Desai, D., Gu, Y., and Morgan, D. (1992). Activation of human cyclin-dependent kinases in vitro. Molec. Biol. of the Cell, in press. |
DeVoto, S., Mudryj, M., Pines, J., Hunter, T., and Nevins, J. (1992). A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33 CDK2 is a component of the E2F-cyclin A complex. Cell 68:167-176. |
Enoch, T., and Nurse, P. (1990). Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell 60:665-673. |
Elledge, S. J., and Spottswood, M. R. (1991). A new human p34 protein kinase, CDK2, identified by complementation of a CDC28 mutation in S. cerevisiae, is a homolog of Xenopus Eg 1. EMBO J 10:2653-2659. |
Elledge, S., Richman, R., Hall, F., Williams, F., Lodgson, N., and Harper, W. (1992). CDK2 encodes a 33-kDaa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. Proc. Nat. Acad. Sci. USA, in press. |
Fang, F., and Newport, J. (1991). Evidence that the G1-S and G2-M transistions are controlled by different CDC2 proteins in higher eukaryotes. Cell 66:731-742. |
Giordano, A., Lee, J., Scheppler, J., Herrmann, C., Harlow, E., Deuschle, U., Beach, D., and Franza, R. (1991). Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A. Science 253:1271-1275. |
Girard, F., Strausfeld, U., Fernanadez, A., and Lamb, N. (1991). Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67: 1169-1179. |
Hartwell, L. (1991). Twenty-five years of cell cycle genetics. Gentics 129: 975-980. |
Hunter, T., and Pines, J. (1991). Cyclins and Cancer. Cell 66:1071-1074. |
Lahue, E., Smith, A., and Orr-Weaver, T. (1991). A novel cyclin gene from Drosophila complements CLN function in yeast. Genes and Dev. 5:2166-2175. |
Lamb, N., Fernandez, A., Watrin, A., Labbe, J., and Cavadore, J. (1990). Microinjection of the p34 CDC2 kinase induces marked changes in cell shape, cytoskeletal organization and chromatin structure in mammalian fibroblasts. Cell 60:151-165. |
Lehner, C., and O'Farrell, P. (1989). Expression and function of Drosophila cyclin A during embryonic cell progression. Cell 56:957-968. |
Leopold, P., and O'Farrell, P. (1991). An evolutionarily conserved cyclin homolog from Drosphila rescues yeast deficient in G1 cyclins. Cell 66: 1207-1216. |
Lohka, F., and Masui, Y. (1983). Formation in vitro of sperm pronuclei and mitotic chromosomes induced by amphibian ooplasmic components. Science 220:719-721. |
Maller, J. (1991). Mitotic control. Curr. Op. in Cell Biol. 3:269-275. |
Marraccino, R., Firpo, E., and Roberts, J. (1992). Activation of the p34 CDC2 protein kinase at the start of S phase in the human cell cycle. Molec. Biol. of the Cell 3: 389-401. |
Masui, Y., and Markert, C. (1971). Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes. J. Exp. Zool. 177:129-146. |
Miller, A. D., and Rosman, G. (1989). Improved retroviral vectors of gene transfer and expression. BioTechniques 7, 980-990. |
Mudryj, M., DeVoto, S., Hiebert, S., Hunter, T., Pines, J., and Nevins, J. (1991) . Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. Cell 65:1243-1253. |
Ohtsubo, M., Yoshida, T., Seino, H., Nishitani, H., Clark, K., Sprague, K., Frasch, M., and Nishimoto, T. (1991). Mutation of the hamster cell cycle gene RCC! is complemented by the homologous genes of Drosophila and S. cerevisiae. EMBO J. 10, 1265-1273. |
Osmani, A., McGuire, S., and Osmani, S. (1991). Parallel regulation of the NIMA and p34CDC2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans. Cell 67:283-291. |
Pardee, A., Medrano, E., and Rossow, P. (1981). A labile protein model for growth control of mammalian cells. In: The biology of normal human growth, Ritzen et al., eds. Raven Press. |
Pines, J., and Hunter, T. (1987). Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs. EMBO J. 6:2987-2995. |
Pondaven, P., Meijer, L., and Beach, D. (1990). Activation of M-phase specific histone H1 kinase by modification of the phosphorylation of its p34 CDC2 and cyclin componenets. Genes and Dev. 4:9-17. |
Rosenblatt, J., Gu, Y., and Morgan, D. (1992). Human cyclin dependent kinase 2 (CDK2) is activated during the S and G2 phases of the cell cycle and associates with cyclin A. Proc. Nat. Acad. Sci. USA, in press. |
Rossow, P., Riddle, B., and Pardee, A. (1979). Synthesis of labile, serum-dependent protein in early G1 controls animal cell growth. Proc. Nat. Acad. Sci. USA, 76:4446-4450. |
Schneiderman, M., Dewey, W., and Highfield, D. (1971). Inhibition of DNA synthesis in synchronized Chinese hamster cells treated in G1 with cycloheximide. Exp. Cell Re. 67:147-155. |
Shirodkar, S., Ewen, M., DeCaprio, J., Morgan, J., Livingston, D., and Chittenden, T. (1992). The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle regulated manner. Cell 68:157-166. |
Smith, L., and Ecker, R. (1971). The interactions of steroids, with R. pipien oocytes in the induction of maturation. Dev. Bio. 25:233-247. |
Solomon, M., Lee, T., and Kirschner, M. (1992). Role of phosphorylation in p34 CDC2 activation: identification of an activating kinase. Molec. Biol. of the Cell 3:13-27. |
Tsai, L., Harlow, E., and Meyerson, M. (1991). Isolation of the human CDK2 gene that encodes the cyclin-A and adenovirus E1A-associated p33 kinase. Nature 353:174-177. |
Westendorf, J., Sweson, K., and Ruderman, J. (1989). The role of cyclin B in meiosis I. J. Cell Biol. 108:1431-1444. |
Wynford-Thomas, D., LaMontagne, A., Marin, G., and Prescott, D. (1985). Location of the isoleucine arrest point in CHO in 3T3 cells. Exp. Cell. Res. 158, 525-532. |
Number | Date | Country | |
---|---|---|---|
Parent | 764309 | Sep 1991 |