This application is a continuation of U.S. Ser. No. 07/279,485 (filed Dec. 2, 1988 and abandoned May 15, 1992), which is a continuation-in-part application of U.S. Ser. No. 06/939,658 (filed Dec. 9, 1986), which is a continuation-in-part of U.S. Ser. No. 06/932,767 (filed Nov. 18, 1986 and abandoned Jul. 15, 1988), which is a continuation-in-part of U.S. Ser. No. 06/868,410 (filed May 29, 1986 and abandoned Jul. 15, 1988). Indirectly related patent applications include the series directed to Factor VIII: U.S. Ser. No. 07/386,280 (filed Jul. 28, 1989), now abandoned, which is a continuation-in-part of U.S. Ser. No. 07/136,478 (filed Dec. 23, 1987 and abandoned May 22, 1990), which is a file wrapper continuation of U.S. Ser. No. 06/644,036 (filed Aug. 24, 1984 and abandoned Dec. 23, 1987), which is a continuation-in-part of U.S. Ser. No. 06/546,650 (filed Oct. 28, 1983 and issued as U.S. Pat. No. 4,757,006 on Jul. 12, 1988). Another series of indirectly related patent applications directed to Factor VIII B domain deletions are: U.S. Ser. No. 07/409,191 (filed Sep. 19, 1989 and abandoned Feb. 25, 1992), which is a continuation-in-part of U.S. Ser. No. 07/010,085 (filed Apr. 11, 1986 and issued Sep. 19, 1989 as U.S. Pat. No. 4,868,112), which is a continuation-in-part of U.S. Ser. No. 06/725,350 (filed Apr. 12, 1985 and abandoned Mar. 4, 1987). Yet another series of indirectly related applications disclosing Factor VIII co-expression with vWF and/or phospholipid are: U.S. Ser. No. 07/824,765 (filed Jan. 17, 1992 and issued as U.S. Pat. No. 5,250,421), which is a file wrapper continuation of U.S. Ser. No. 07/260,085 (filed Oct. 14, 1988), now abandoned, which is a continuation of U.S. Ser. No. 07/068,865 (filed Jul. 2, 1987 and abandoned Sep. 8, 1989), which is a continuation-in-part of U.S. Ser. No. 07/034,882 (filed Apr. 6, 1987 and abandoned Sep. 8, 1989), which is a continuation-in-part of U.S. Ser. No. 06/942,338 (filed Dec. 16, 1986 and abandoned Aug. 22, 1991, which is a continuation-in-part of U.S. Ser. No. 06/816,031 (filed Jan. 3, 1986 and abandoned Jan. 23, 1989). The contents of these applications are hereby incorporated by reference, as are the contents of International Application WO87/07144 (published Dec. 3, 1987) related to cleavage site mutants.
Certain aspects of the research resulting in the present invention were funded in part by the U.S. Department of Health and Human Services (DHHS) under a Small Business Innovation Research (SBIR) Grant, DHSS Grant No. 1 R43 HL35946-01. The United States Government has certain rights in aspects of this invention.
Number | Name | Date | Kind |
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4749780 | Andersson et al. | Jun 1988 | |
4757006 | Toole, Jr. et al. | Jun 1988 | |
4868112 | Toole, Jr. | Sep 1989 | |
4877614 | Andersson et al. | Oct 1989 | |
4959318 | Foster et al. | Sep 1990 | |
4980456 | Scondella et al. | Dec 1990 | |
5002887 | Larsen et al. | Mar 1991 | |
5004803 | Kaufman et al. | Apr 1991 | |
5045455 | Kao et al. | Sep 1991 | |
5112950 | Mevlien et al. | May 1992 | |
5171844 | Van Ooyen et al. | Dec 1992 | |
5250421 | Kaufman et al. | Oct 1993 |
Number | Date | Country |
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0232112 | Aug 1987 | EPX |
8606101 | Oct 1986 | WOX |
8707144 | Mar 1987 | WOX |
Entry |
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Number | Date | Country | |
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Parent | 279485 | Dec 1988 |
Number | Date | Country | |
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Parent | 939658 | Dec 1986 | |
Parent | 932767 | Nov 1986 | |
Parent | 868410 | May 1986 |