Information
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Patent Application
-
20030235915
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Publication Number
20030235915
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Date Filed
April 25, 200222 years ago
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Date Published
December 25, 200321 years ago
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Inventors
-
Original Assignees
-
CPC
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US Classifications
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International Classifications
- C12N015/85
- C07H021/04
- C12P021/02
- C12N005/06
Abstract
Human nucleic acid sequences—mRNA, cDNA, genomic sequences—from breast tumor tissue, which code for gene products or parts thereof, and their use, are described. In addition, the polypeptides that can be obtained by way of the sequences and their use are described.
Description
[0001] The invention relates to human nucleic acid sequences from breast tumor tissue, which code for gene products or parts thereof, their functional genes that code at least one bioactive polypeptide and their use.
[0002] In addition, the invention relates to the polypeptides that can be obtained via the sequences and their use.
[0003] One of the main causes of death in women is breast cancer, for control of which new therapies are necessary. Previously used therapies, such as, e.g., chemotherapy, hormone therapy or surgical removal of tumor tissue, frequently do not result in a complete cure.
[0004] The cancer phenomenon often goes along with overexpression or underexpression of certain genes in degenerated cells, it still being unclear whether these altered expression rates are the cause or the result of the malignant transformation. Identification of these genes would be an important step for development of new therapies against cancer. Spontaneous formation of cancer is often preceded by a host of mutations. They can have the most varied effects on the expression pattern in the affected tissue, such as, e.g., underexpression or overexpression, but also expression of shortened genes. Several such changes due to these mutation cascades can ultimately lead to malignant degeneration. The complexity of these relationships makes an experimental approach very difficult.
[0005] A database that consists of so-called ESTs is used to look for tumor-related candidate genes, i.e., genes that can be considered as the cause or the result of malignant degenerations in normal human tissue. ESTs (expressed sequence tags) are sequences of cDNAs, i.e., mRNAs transcribed in reverse, therefore molecules that reflect gene expression. The EST sequences are determined for normal and degenerated tissue. These databases are offered to some extent commercially by various companies. The ESTs of the LifeSeq database, which is used here, are generally between 150 and 350 nucleotides long. They represent a pattern that is unmistakable for a certain gene, although this gene is normally very much longer (>2000 nucleotides). By comparison of the expression patterns of normal and tumor tissue, ESTs can be identified which are important for tumor formation and proliferation. There is, however, the following problem: Since the EST sequences that are found can belong to different regions of an unknown gene due to different constructions of cDNA libraries, in this case a completely incorrect ratio of the occurrence of these ESTs in the respective tissue would arise. This would only be noticed when the complete gene is known and thus ESTs can be assigned to the same gene.
[0006] It has now been found that this error possibility can be reduced if all ESTs from the respective tissue type are assembled beforehand, before the expression patterns are compared to one another. Overlapping ESTs of the same gene were thus combined into longer sequences (see FIG. 1, FIG. 2a and FIG. 3). This lengthening and thus coverage of an essentially larger gene region in each of the respective bases are intended to largely avoid the above-described error. Since there were no existing software products for this purpose, programs for assembling genomic sections were employed, which were used modified and to which our own programs were added. A flow chart of the assembly procedure is shown in FIGS. 2b1-2b4.
[0007] Nucleic acid sequences Seq. ID No. 2-67, 149-161, and 201-202, which play a part as candidate genes in breast tumors, have now been found.
[0008] Nucleic acid sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161 are of special interest.
[0009] The invention thus relates to nucleic acid sequences that code a gene product or a part thereof, comprising
[0010] a) a nucleic acid sequence selected from the group of nucleic acid sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, 160-161
[0011] b) an allelic variation of the nucleic acid sequences named under a) or
[0012] c) a nucleic acid sequence that is complementary to the nucleic acid sequences named under a) or b).
[0013] In addition, the invention relates to a nucleic acid sequence according to one of the sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161 or a complementary or allelic variant thereof and the nucleic acid sequences thereof, which have 90% to 95% homology to a human nucleic acid sequence.
[0014] The invention also relates to nucleic acid sequences Seq. ID No. 2 to Seq. ID No. 67 as well as Seq. ID No. 149 to Seq. ID No. 201-202, which are expressed elevated in breast tumor tissue.
[0015] The invention further relates to nucleic acid sequences comprising a portion of the above-mentioned nucleic acid sequences in such a sufficient amount that they hybridize with sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159 and 160-161.
[0016] The nucleic acid sequences according to the invention generally have a length of at least 50 to 4500 bp, preferably a length of at least 150 to 4000 bp, especially a length of 450 to 3500 bp.
[0017] With the partial sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161 according to the invention, expression cassettes can also be built using current process practice, whereby on the cassette at least one of the nucleic acid sequences according to the invention is combined with at least one control or regulatory sequence generally known to one skilled in the art, such as, e.g., a suitable promoter. The sequences according to the invention can be inserted in a sense or antisense orientation.
[0018] A large number of expression cassettes or vectors and promoters which can be used are known in the literature.
[0019] Expression cassettes or vectors are defined as:
[0020] 1. bacterial, such as, e.g., phagescript, pBs, φX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene), pTrc99A, pKK223-3, pKK233-3, pDR540, pRIT5 (Pharmacia), 2. eukaryotic, such as, e.g., pWLneo, pSV2cat, pOG44, pXT1, pSG (Stratagene), pSVK3, pBPV, pMSG, pSVL (Pharmacia).
[0021] A control or regulatory sequence is defined as suitable promoters. Here, two preferred vectors are the pKK232-8 and the PCM7 vector. In particular, the following promoters are intended: lacI, lacZ, T3, T7, gpt, lambda PR, trc, CMV, HSV thymidine-kinase, SV40, LTRs from retrovirus and mouse metallothionein-I.
[0022] The DNA sequences located on the expression cassette can code a fusion protein which comprises a known protein and a bioactive polypeptide fragment.
[0023] The expression cassettes are likewise the subject matter of this invention.
[0024] The nucleic acid fragments according to the invention can be used to produce full-length genes. The genes that can be obtained are likewise the subject matter of this invention.
[0025] The invention also relates to the use of the nucleic acid sequences according to the invention and the gene fragments that can be obtained from use.
[0026] The nucleic acid sequences according to the invention can be moved with suitable vectors into host cells, in which as the heterologous part, the genetic information which is contained on the nucleic acid fragments and which is expressed is located.
[0027] The host cells containing the nucleic acid fragments are likewise the subject matter of this invention.
[0028] Suitable host cells are, e.g., prokaryotic cell systems such as E. coli or eukaryotic cell systems such as animal or human cells or yeasts.
[0029] The nucleic acid sequences according to the invention can be used in the sense or antisense form.
[0030] Production of polypeptides or their fragments is done by cultivation of the host cells according to current cultivation methods and subsequent isolation and purification of the peptides or fragments, likewise using current methods. The invention further relates to nucleic acid sequences, which code at least a partial sequence of a bioactive polypeptide.
[0031] This invention further relates to polypeptide partial sequences, so-called ORF (open-reading-frame)-peptides according to the sequence protocols Seq. ID No. 71-79, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198.
[0032] The invention further relates to the polypeptide sequences that have at least 80% homology, especially 90% homology to the polypeptide partial sequences of Seq. ID No. 71-179, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198 according to the invention.
[0033] The invention also relates to antibodies that are directed against a polypeptide or a fragment thereof and that are coded by the nucleic acids of sequences Seq. ID No. 71-79, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198 according to the invention.
[0034] Antibodies are defined especially as monoclonal antibodies.
[0035] The polypeptides of sequences Seq. ID No. 71-79, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198 according to the invention can also be used as tools for finding active ingredients against breast cancer, which is likewise the subject matter of this invention.
[0036] Likewise the subject matter of this invention is the use of nucleic acid sequences according to sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161 for expression of polypeptides, which can be used as tools for finding active ingredients against breast cancer.
[0037] The invention also relates to the use of the found polypeptide partial sequences Seq. ID No. 71-79, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198 for the production of a pharmaceutical agent for treatment of breast cancer.
[0038] The invention also relates to pharmaceutical agents that contain at least one polypeptide partial sequence Seq. ID No. 71-79, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198.
[0039] The nucleic acid sequences found according to the invention can also be genomic or mRNA sequences.
[0040] The invention also relates to genomic genes, their exon and intron structures and their splice versions that can be obtained from cDNAs of sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161, and their use together with suitable regulatory elements, such as suitable promoters and/or enhancers.
[0041] With the nucleic acids according to the invention (cDNA sequences), genomic BAC, PAC and Cosmid libraries are screened and specifically human clones are isolated via complementary base pairing (hybridization). The BAC, PAC and Cosmid clones isolated in this way are hybridized using fluorescence-in-situ hybridization on metaphase chromosomes and the corresponding chromosome sections on which the corresponding genomic genes lie are identified. BAC, PAC and Cosmid clones are sequenced in order to clarify the corresponding genomic genes in their complete structure (promoters, enhancers, silencers, exons and introns). BAC, PAC and Cosmid clones can be used as independent molecules for gene transfer (see FIG. 5).
[0042] The invention also relates to BAC, PAC and Cosmid clones containing functional genes and their chromosomal localization according to sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161 for use as vehicles for gene transfer.
[0043] Meanings of Technical Terms and Abbreviations
[0044] Nucleic acids=Nucleic acids in this invention are defined as: mRNA, partial cDNA, full-length cDNA and genomic genes (chromosomes).
[0045] ORF=Open Reading Frame, a defined sequence of amino acids which can be derived from the cDNA sequence.
[0046] Contig=A set of DNA sequences that can be combined as a result of very great similarities into one sequence (consensus).
[0047] Singleton=A contig that contains only one sequence.
[0048] Module=Domain of a protein with a defined sequence, which represents one structural unit and which occurs in various proteins.
[0049] N=selectively the nucleotide A, T, G or C.
[0050] X=selectively one of the 20 naturally occurring amino acids.
[0051] Explanation of the Alignment Parameters
[0052] minimal initial match=minimal initial identity area
[0053] maximum pads per read=maximum number of insertions
[0054] maximum percent mismatch=maximum deviation in %
EXPLANATION OF FIGURES
[0055]
FIG. 1 shows the systematic gene search in the Incyte LifeSeq database.
[0056]
FIG. 2
a
shows the principle of EST assembling
[0057]
FIGS. 2
b
1
-2b4 show the entire principle of EST assembling
[0058]
FIG. 3 shows the in-silico subtraction of gene expression in various tissues
[0059]
FIG. 4
a
shows the determination of tissue-specific expression via electronic Northern
[0060]
FIG. 4
b
shows the electronic Northern
[0061]
FIG. 5 shows the isolation of genomic BAC and PAC clones.
[0062] The following examples explain the production of the nucleic acid sequences according to the invention without limiting the invention to these examples and nucleic acid sequences.
EXAMPLE 1
[0063] Search for Tumor-Related Candidate Genes
[0064] First, all ESTs of the corresponding tissue from the LifeSeq database (from October 1997) were extracted. They were then assembled by means of the GAP4 program of the Staden package with the parameters 0% mismatch, 8 pads per read and a minimal match of 20. The sequences (fails) not recorded in the GAP4 database were assembled first at 1% mismatch and then again at 2% mismatch with the database. Consensus sequences were computed from the contigs of the database that consisted of more than one sequence.
[0065] The singletons of the database, which consisted of only one sequence, were re-assembled at 2% mismatch with the sequences not recorded in the GAP4 database. In turn, the consensus sequences were determined for the contigs. All other ESTs were re-assembled at 4% mismatch. The consensus sequences were extracted once again and finally assembled with the previous consensus sequences and the singletons and the sequences not recorded in the database at 4% mismatch. The consensus sequences were formed and used with the singletons and fails as the initial basis for tissue comparisons. This procedure ensured that among the parameters used, all sequences represented gene regions independent of one another.
[0066]
FIGS. 2
b
1
-2b4 illustrate the lengthening of the breast tumor tissue ESTs.
[0067] The sequences of the respective tissue assembled in this way were then compared to one another by means of the same program (FIG. 3). To do this, first all sequences of the first tissue were input into the database. (It was therefore important that they were independent of one another).
[0068] Then, all sequences of the second tissue were compared to all those of the first. The result was sequences that were specific to the first or the second tissue as well as those which occurred in both. In the latter, the ratio of the frequency of occurrence in the respective tissue was evaluated. All programs pertaining to the evaluation of the assembled sequences were themselves developed.
[0069] All sequences that occurred more than four times in respectively one of the compared tissues and all that occurred at least five times as often in one of the two tissues were further studied. These sequences were subjected to an electronic Northern (see Example 2.1), by which the distribution in all tumor and normal tissues was studied (see FIG. 4a and FIG. 4b). The relevant candidates were then lengthened using all Incyte ESTs and all ESTs of public databases (see Example 3). Then, the sequences and their translation into possible proteins were compared to all nucleotide and protein databases and were studied for possible regions that code for proteins.
EXAMPLE 2
[0070] Algorithm for Identification and Lengthening of Partial cDNA Sequences with Altered Expression Pattern
[0071] An algorithm for finding overexpressed or underexpressed genes will be explained below. The individual steps are also summarized in a flow chart for the sake of clarity (see FIG. 4b).
[0072] 2.1. Electronic Northern Blot
[0073] By means of a standard program for homology search, e.g., BLAST (Altschul, S. F.; Gish, W.; Miller, W.; Myers, E. W. and Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410), BLAST2 (Altschul, S. F.; Madden, T. L.; Schäffer, A. A.; Zhang, J.; Zhang, Z.; Miller, W., and Lipman, D. J. (1997) Nucleic Acids Research 25 3389-3402) or FASTA (Pearson, W. R. and Lipman, D. J. (1988) Proc. Natl. Acad. Sci. USA 85 2444-2448), the homologous sequences in various EST libraries (private or public) arranged by tissues are determined for a partial DNA sequence S, e.g., an individual EST or a contig of ESTs. The (relative or absolute) tissue-specific occurrence frequencies of this partial sequence S which were determined in this way are called electronic Northern Blots.
[0074] 2.1.1
[0075] Analogously to the procedure described under 2.1, the sequence Seq. ID No. 2 was found which occurs 9× more heavily in breast tumor tissue than in normal tissue.
[0076] The possible function of this gene region relates to a 17-kDa-interferon-inducible gene.
[0077] The result is as follows:
1|
|
Electronic Northern for Seq. ID NO.: 2
TU-
MORRATIOS
% freq.% freq.N/TT/N
|
NORMAL
Bladder0.00000.01020.0000undef
Breast0.00530.04580.11658.5843
Ovary0.00300.03380.089911.1243
Endocrine tissue0.00000.0000undefundef
Gastrointestinal0.00390.01430.27143.6843
Brain0.00850.00990.86011.1626
Hematopoietic0.00280.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.0000undefundef
Heart0.00740.0000undef0.0000
Testicles0.00000.01170.0000undef
Lungs0.00370.00241.58010.6329
Stomach-esophagus0.00970.00771.25990.7937
Muscle-skeleton0.00340.01200.28553.5025
Kidneys0.00300.0000undef0.0000
Pancreas0.00380.0000undef0.0000
Penis0.00300.10660.028135.6161
Prostate0.00480.00431.11860.8939
Uterus0.00830.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0093
Prostatic hyperplasia0.0030
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0035
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0000
Hematopoietic0.0039
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0228
Endocrine tissue0.0000
Fetal0.0082
Gastrointestinal0.0244
Hematopoietic0.0057
Skin-muscle0.0032
Testicles0.0000
Lungs0.0082
Nerves0.0010
Prostate0.0128
Sensory organs0.0000
|
[0078] 2.1.2
[0079] Analogously to the procedure described under 2.1, the sequence Seq. ID No. 5 was found which occurs 30× more heavily in breast tumor tissue than in normal tissue.
[0080] The possible function of this gene region relates to “macrophage migration inhibition factor related protein 14 (MRP-14).”
[0081] The result is as follows:
2|
|
Electronic Northern for Seq. ID NO.: 5
TU-
MORRATIOS
% freq.% freq.N/TT/N
|
NORMAL
Bladder0.00930.15080.061616.2223
Breast0.00130.03920.034029.4320
Ovary0.01520.0000undef0.0000
Endocrine tissue0.00180.00270.66981.4930
Gastrointestinal0.01740.00483.66420.2729
Brain0.00510.00550.92891.0765
Hematopoietic0.09930.0000undef0.0000
Skin0.02490.0000undef0.0000
Hepatic0.00000.01290.0000undef
Heart0.00530.0000undef0.0000
Testicles0.00610.0000undef0.0000
Lungs0.02610.03070.85081.1753
Stomach-esophagus0.10620.02304.61970.2165
Muscle-skeleton0.01710.01800.95171.0508
Kidneys0.00000.00680.0000undef
Pancreas0.01140.0000undef0.0000
Penis0.12580.16000.78621.2720
Prostate0.00000.0000undefundef
Uterus0.08260.0000undef0.0000
Breast hyperplasia0.0036
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0178
Sensory organs0.0000
White blood cells0.1018
FETUS
Development0.0000
Gastrointestinal0.0062
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0037
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0052
Gastrointestinal0.0122
Hematopoietic0.0057
Skin-muscle0.0000
Testicles0.0000
Lungs0.0410
Nerves0.0000
Prostate0.0449
Sensory organs0.0000
|
[0082] 2.1.3
[0083] Analogously to the procedure described under 2.1, the sequence Seq. ID No. 16 was found which occurs 30× more heavily in breast tumor tissue than in normal tissue.
[0084] The possible function of this gene region relates to human Tim23, which is located in the protein translocase complex of the inside mitochondrial membrane.
[0085] The result is as follows:
3|
|
Electronic Northern for Seq. ID NO.: 16
TU-
MORRATIOS
% freq.% freq.N/TT/N
|
NORMAL
Bladder0.00460.00510.90921.0998
Breast0.00130.01530.087411.4458
Ovary0.00000.00260.0000undef
Endocrine tissue0.00910.00821.11630.8958
Gastrointestinal0.01160.00951.22140.8187
Brain0.00760.00551.39340.7177
Hematopoietic0.00840.0000undef0.0000
Skin0.01990.0000undef0.0000
Hepatic0.01980.00653.06060.3267
Heart0.01060.0000undef0.0000
Testicles0.01830.0000undef0.0000
Lungs0.01000.00244.21370.2373
Stomach-esophagus0.01930.0000undef0.0000
Muscle-skeleton0.00340.00600.57101.7513
Kidneys0.00300.0000undef0.0000
Pancreas0.00000.0000undefundef
Penis0.00000.0000undefundef
Prostate0.00480.00850.55931.7879
Uterus0.00170.00710.23214.3088
Breast hyperplasia0.0073
Small intestine0.0031
Prostatic hyperplasia0.0030
Seminal vesicles0.0089
Sensory organs0.0118
White blood cells0.0009
FETUS
Development0.0154
Gastrointestinal0.0000
Brain0.0125
Hematopoietic0.0000
Heart-blood vessels0.0041
Lungs0.0111
Kidneys0.0000
Prostate0.0499
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0068
Endocrine tissue0.0000
Fetal0.0064
Gastrointestinal0.0244
Hematopoietic0.0057
Skin-muscle0.0065
Testicles0.0156
Lungs0.0164
Nerves0.0030
Prostate0.0000
Sensory organs0.0000
|
[0086] In an analogous procedure, the following Northerns were also found:
4|
|
TU-
MORRATIOS
% freq.% freq.N/TT/N
|
Electronic Northern for SEQ. ID NO.: 3
NORMAL
Bladder0.00460.01280.36372.7495
Breast0.00670.01740.38222.6162
Ovary0.00610.0000undef0.0000
Endocrine tissue0.00180.00820.22334.4791
Gastrointestinal0.00390.00480.81431.2281
Brain0.03390.01103.09640.3230
Hematopoietic0.01120.0000undef0.0000
Skin0.01490.0000undef0.0000
Hepatic0.00500.0000undef0.0000
Heart0.00640.0000undef0.0000
Testicles0.01830.0000undef0.0000
Lungs0.01370.0000undef0.0000
Stomach-esophagus0.00970.01530.63001.5874
Muscle-skeleton0.00860.01200.71381.4010
Kidneys0.00300.03420.086811.5165
Pancreas0.00570.01100.51431.9446
Penis0.00300.0000undef0.0000
Prostate0.00240.00850.27973.5758
Uterus0.01160.00711.62460.6155
Breast hyperplasia0.0036
Small intestine0.0093
Prostatic hyperplasia0.0030
Seminal vesicles0.0000
Sensory organs0.0118
White blood cells0.0061
FETUS
Development0.0000
Gastrointestinal0.0092
Brain0.0188
Hematopoietic0.0079
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0204
Ovary-uterus0.0091
Endocrine tissue0.0000
Fetal0.0093
Gastrointestinal0.0000
Hematopoietic0.0114
Skin-muscle0.0227
Testicles0.0000
Lungs0.0082
Nerves0.0291
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 4
NORMAL
Bladder0.00930.02560.36372.7495
Breast0.01330.02830.47042.1256
Ovary0.00910.01040.87651.1409
Endocrine tissue0.02740.04900.55821.7916
Gastrointestinal0.01160.00951.22140.8187
Brain0.02120.01641.29020.7751
Hematopoietic0.00840.0000undef0.0000
Skin0.03480.0000undef0.0000
Hepatic0.01490.02590.57391.7426
Heart0.01910.01371.38730.7208
Testicles0.01220.0000undef0.0000
Lungs0.01620.01650.97821.0223
Stomach-esophagus0.02900.01531.88990.5291
Muscle-skeleton0.00690.01200.57101.7513
Kidneys0.01780.00682.60500.3839
Pancreas0.00380.02210.17145.8337
Penis0.01800.0000undef0.0000
Prostate0.02140.02340.91521.0926
Uterus0.01820.02140.85101.1751
Breast hyperplasia0.0073
Small intestine0.0218
Prostatic hyperplasia0.0357
Seminal vesicles0.0178
Sensory organs0.0118
White blood cells0.0218
FETUS
Development0.0000
Gastrointestinal0.0154
Brain0.0125
Hematopoietic0.0000
Heart-blood vessels0.0123
Lungs0.0111
Kidneys0.0124
Prostate0.0499
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0183
Endocrine tissue0.0000
Fetal0.0076
Gastrointestinal0.0488
Hematopoietic0.0000
Skin-muscle0.0259
Testicles0.0000
Lungs0.0000
Nerves0.0090
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 6
NORMAL
Bladder0.00000.01020.0000undef
Breast0.00530.01960.27183.6790
Ovary0.00610.00521.16860.8557
Endocrine tissue0.00180.00270.66981.4930
Gastrointestinal0.00390.00950.40712.4562
Brain0.00760.00332.32230.4306
Hematopoietic0.00420.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.00990.01290.76511.3069
Heart0.00640.0000undef0.0000
Testicles0.00000.01170.0000undef
Lungs0.00500.01420.35112.8478
Stomach-esophagus0.00000.02300.0000undef
Muscle-skeleton0.00340.0000undef0.0000
Kidneys0.01190.01370.86831.1517
Pancreas0.00380.00550.68571.4584
Penis0.00300.0000undef0.0000
Prostate0.01670.01281.30510.7662
Uterus0.00330.01420.23214.3088
Breast hyperplasia0.0036
Small intestine0.0062
Prostatic hyperplasia0.0119
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0009
FETUS
Development0.0154
Gastrointestinal0.0062
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0041
Lungs0.0037
Kidneys0.0062
Prostate0.0249
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0023
Endocrine tissue0.0000
Fetal0.0047
Gastrointestinal0.0122
Hematopoietic0.0057
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0000
Prostate0.0256
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 7
NORMAL
Bladder0.01860.00513.63700.2750
Breast0.01470.02610.56061.7838
Ovary0.01820.02340.77911.2836
Endocrine tissue0.04560.02451.86050.5375
Gastrointestinal0.02330.01901.22140.8187
Brain0.03140.02301.36390.7332
Hematopoietic0.01960.03780.51751.9325
Skin0.01990.0000undef0.0000
Hepatic0.00500.03880.12757.8416
Heart0.03280.02751.19470.8371
Testicles0.01830.03510.52241.9144
Lungs0.01490.02840.52671.8986
Stomach-esophagus0.01930.04600.42002.3811
Muscle-skeleton0.02230.04800.46392.1554
Kidneys0.02080.02051.01300.9871
Pancreas0.02460.00554.45690.2244
Penis0.04490.02671.68460.5936
Prostate0.01670.03830.43502.2987
Uterus0.02310.02141.08310.9233
Breast hyperplasia0.0109
Small intestine0.0125
Prostatic hyperplasia0.0357
Seminal vesicles0.0356
Sensory organs0.0000
White blood cells0.0165
FETUS
Development0.0307
Gastrointestinal0.0247
Brain0.0375
Hematopoietic0.0118
Heart-blood vessels0.0204
Lungs0.0296
Kidneys0.0185
Prostate0.0249
Sensory organs0.0279
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0068
Ovary-uterus0.0068
Endocrine tissue0.0000
Fetal0.0093
Gastrointestinal0.0000
Hematopoietic0.0114
Skin-muscle0.0097
Testicles0.0078
Lungs0.0082
Nerves0.0100
Prostate0.0000
Sensory organs0.0155
Electronic Northern for SEQ. ID NO.: 8
NORMAL
Bladder0.01390.02810.49592.0163
Breast0.00800.04140.19315.1778
Ovary0.01220.02600.46742.1393
Endocrine tissue0.02740.03540.77281.2940
Gastrointestinal0.02520.03330.75611.3226
Brain0.02370.01751.35470.7382
Hematopoietic0.00980.0000undef0.0000
Skin0.01490.16930.088111.3508
Hepatic0.01490.01291.14770.8713
Heart0.03810.04120.92491.0812
Testicles0.01830.0000undef0.0000
Lungs0.01740.06150.28363.5259
Stomach-esophagus0.00970.03830.25203.9685
Muscle-skeleton0.01710.01800.95171.0508
Kidneys0.02080.05480.37992.6323
Pancreas0.02840.0000undef0.0000
Penis0.01800.10660.16855.9360
Prostate0.01190.02130.55931.7879
Uterus0.01160.02850.40612.4622
Breast hyperplasia0.0109
Small intestine0.0374
Prostatic hyperplasia0.0386
Seminal vesicles0.0356
Sensory organs0.0000
White blood cells0.0113
FETUS
Development0.0307
Gastrointestinal0.0216
Brain0.0188
Hematopoietic0.0079
Heart-blood vessels0.0245
Lungs0.0259
Kidneys0.0062
Prostate0.0748
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0068
Ovary-uterus0.0205
Endocrine tissue0.0000
Fetal0.0233
Gastrointestinal0.0366
Hematopoietic0.0000
Skin-muscle0.0615
Testicles0.0078
Lungs0.0164
Nerves0.0181
Prostate0.0192
Sensory organs0.0387
Electronic Northern for SEQ. ID NO.: 9
NORMAL
Bladder0.00460.01280.36372.7495
Breast0.00530.02180.24464.0878
Ovary0.01220.00264.67450.2139
Endocrine tissue0.00360.01090.33492.9861
Gastrointestinal0.02130.00484.47840.2233
Brain0.00510.0000undef0.0000
Hematopoietic0.00280.0000undef0.0000
Skin0.03480.0000undef0.0000
Hepatic0.02970.0000undef0.0000
Heart0.00640.01370.46242.1624
Testicles0.00000.0000undefundef
Lungs0.03240.01891.71180.5842
Stomach-esophagus0.00000.00770.0000undef
Muscle-skeleton0.00170.0000undef0.0000
Kidneys0.03570.0000undef0.0000
Pancreas0.02080.0000undef0.0000
Penis0.00000.0000undefundef
Prostate0.02140.00852.51690.3973
Uterus0.00500.0000undef0.0000
Breast hyperplasia0.0145
Small intestine0.0031
Prostatic hyperplasia0.0178
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0000
FETUS
Development0.0000
Gastrointestinal0.0062
Brain0.0000
Hematopoietic0.0039
Heart-blood vessels0.0041
Lungs0.0148
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0068
Endocrine tissue0.0000
Fetal0.0058
Gastrointestinal0.0244
Hematopoietic0.0000
Skin-muscle0.0130
Testicles0.0000
Lungs0.0246
Nerves0.0020
Prostate0.0256
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 11
NORMAL
Bladder0.01390.01790.77931.2831
Breast0.01330.04140.32193.1067
Ovary0.00000.01560.0000undef
Endocrine tissue0.00730.00272.67910.3733
Gastrointestinal0.00580.00481.22140.8187
Brain0.00930.01530.60821.6441
Hematopoietic0.00980.0000undef0.0000
Skin0.01990.0000undef0.0000
Hepatic0.00500.01290.38262.6139
Heart0.00850.01370.61661.6218
Testicles0.00610.01170.52241.9144
Lungs0.02370.02131.11200.8993
Stomach-esophagus0.00970.00771.25990.7937
Muscle-skeleton0.01030.01800.57101.7513
Kidneys0.00300.04790.062016.1231
Pancreas0.00380.02210.17145.8337
Penis0.00900.05330.16855.9360
Prostate0.00710.00850.83901.1919
Uterus0.00500.02140.23214.3088
Breast hyperplasia0.0182
Small intestine0.0062
Prostatic hyperplasia0.0000
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0331
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0340
Ovary-uterus0.0023
Endocrine tissue0.0000
Fetal0.0006
Gastrointestinal0.0000
Hematopoietic0.0057
Skin-muscle0.0032
Testicles0.0000
Lungs0.0656
Nerves0.0030
Prostate0.0000
Sensory organs0.0387
Electronic Northern for SEQ. ID NO.: 12
NORMAL
Bladder0.00930.00263.63700.2750
Breast0.01600.05450.29363.4065
Ovary0.00610.00780.77911.2836
Endocrine tissue0.00910.00821.11630.8958
Gastrointestinal0.00190.0000undef0.0000
Brain0.00340.0000undef0.0000
Hematopoietic0.00140.0000undef0.0000
Skin0.01490.0000undef0.0000
Hepatic0.00000.0000undefundef
Heart0.00210.02750.077112.9744
Testicles0.00610.0000undef0.0000
Lungs0.00250.0000undef0.0000
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00340.0000undef0.0000
Kidneys0.00890.0000undef0.0000
Pancreas0.00190.0000undef0.0000
Penis0.01200.0000undef0.0000
Prostate0.00480.01060.44752.2349
Uterus0.00660.0000undef0.0000
Breast hyperplasia0.0218
Small intestine0.0000
Prostatic hyperplasia0.0238
Seminal vesicles0.0000
Sensory organs0.0235
White blood cells0.0044
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0125
Hematopoietic0.0039
Heart-blood vessels0.0000
Lungs0.0074
Kidneys0.0000
Prostate0.0249
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0046
Endocrine tissue0.0000
Fetal0.0041
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0070
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 13
NORMAL
Bladder0.01860.01281.45480.6874
Breast0.00930.02830.32933.0366
Ovary0.01220.00264.67450.2139
Endocrine tissue0.02370.01361.74140.5742
Gastrointestinal0.02710.0000undef0.0000
Brain0.00680.01200.56301.7762
Hematopoietic0.00840.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.01980.00653.06060.3267
Heart0.03070.02751.11760.8948
Testicles0.01220.02340.52241.9144
Lungs0.01250.00472.63360.3797
Stomach-esophagus0.02900.02301.25990.7937
Muscle-skeleton0.00860.01800.47582.1015
Kidneys0.01190.01370.86831.1517
Pancreas0.00380.01660.22864.3753
Penis0.05390.0000undef0.0000
Prostate0.02140.03410.62921.5892
Uterus0.04460.01423.13310.3192
Breast hyperplasia0.0036
Small intestine0.0093
Prostatic hyperplasia0.0149
Seminal vesicles0.0534
Sensory organs0.0000
White blood cells0.0104
FETUS
Development0.0307
Gastrointestinal0.0308
Brain0.0063
Hematopoietic0.0039
Heart-blood vessels0.0082
Lungs0.0370
Kidneys0.0062
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0204
Ovary-uterus0.0114
Endocrine tissue0.0245
Fetal0.0099
Gastrointestinal0.0000
Hematopoietic0.0285
Skin-muscle0.0130
Testicles0.0000
Lungs0.0082
Nerves0.0110
Prostate0.0128
Sensory organs0.0155
Electronic Northern for SEQ. ID NO.: 14
NORMAL
Bladder0.00000.00770.0000undef
Breast0.00800.02610.30583.2702
Ovary0.00610.02340.25973.8507
Endocrine tissue0.00730.01630.44652.2395
Gastrointestinal0.00780.00481.62850.6141
Brain0.00760.00770.99531.0047
Hematopoietic0.01820.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.03880.0000undef
Heart0.00420.0000undef0.0000
Testicles0.00610.0000undef0.0000
Lungs0.01250.01650.75241.3290
Stomach-esophagus0.00970.01530.63001.5874
Muscle-skeleton0.00340.0000undef0.0000
Kidneys0.01490.01371.08540.9213
Pancreas0.00190.00550.34282.9168
Penis0.00900.02670.33692.9680
Prostate0.05240.03411.53810.6501
Uterus0.00660.0000undef0.0000
Breast hyperplasia0.0036
Small intestine0.0062
Prostatic hyperplasia0.0386
Seminal vesicles0.0000
Sensory organs0.0235
White blood cells0.0113
FETUS
Development0.0154
Gastrointestinal0.0092
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0041
Lungs0.0259
Kidneys0.0247
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0183
Endocrine tissue0.0000
Fetal0.0181
Gastrointestinal0.0366
Hematopoietic0.0285
Skin-muscle0.0324
Testicles0.0078
Lungs0.0246
Nerves0.0020
Prostate0.0705
Electronic Northern for SEQ. ID NO.: 15
NORMAL
Bladder0.00930.01020.90921.0998
Breast0.00270.01960.13597.3580
Ovary0.00000.02340.0000undef
Endocrine tissue0.00550.03810.14356.9675
Gastrointestinal0.00580.01430.40712.4562
Brain0.00760.00661.16120.8612
Hematopoietic0.00840.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.0000undefundef
Heart0.02010.0000undef0.0000
Testicles0.01220.0000undef0.0000
Lungs0.01000.01650.60201.6612
Stomach-esophagus0.00000.01530.0000undef
Muscle-skeleton0.00170.00600.28553.5025
Kidneys0.01190.01370.86831.1517
Pancreas0.00380.0000undef0.0000
Penis0.01200.0000undef0.0000
Prostate0.00950.01280.74581.3409
Uterus0.00660.01420.46422.1544
Breast hyperplasia0.0036
Small intestine0.0187
Prostatic hyperplasia0.0089
Seminal vesicles0.0356
Sensory organs0.0118
White blood cells0.0052
FETUS
Development0.0000
Gastrointestinal0.0123
Brain0.0188
Hematopoietic0.0118
Heart-blood vessels0.0123
Lungs0.0185
Kidneys0.0124
Prostate0.0000
Sensory organs0.0140
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0068
Endocrine tissue0.0000
Fetal0.0064
Gastrointestinal0.0122
Hematopoietic0.0057
Skin-muscle0.0130
Testicles0.0312
Lungs0.0164
Nerves0.0070
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 17
NORMAL
Bladder0.00460.00770.60621.6497
Breast0.00400.02400.16685.9954
Ovary0.00300.01300.23374.2786
Endocrine tissue0.00180.0000undef0.0000
Gastrointestinal0.02710.00952.84990.3509
Brain0.00000.0000undefundef
Hematopoietic0.00420.0000undef0.0000
Skin0.04480.0000undef0.0000
Hepatic0.00000.0000undefundef
Heart0.00000.0000undefundef
Testicles0.00000.02340.0000undef
Lungs0.00870.00711.22900.8137
Stomach-esophagus0.08690.02303.77980.2646
Muscle-skeleton0.00000.0000undefundef
Kidneys0.00000.0000undefundef
Pancreas0.00000.0000undefundef
Penis0.01800.05330.33692.9680
Prostate0.00480.00212.23730.4470
Uterus0.01160.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0125
Prostatic hyperplasia0.0000
Seminal vesicles0.0089
Sensory organs0.0118
While blood cells0.0000
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0039
Heart-blood vessels0.0000
Lungs0.0074
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0000
Gastrointestinal0.0000
Hematopoietic0.0057
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0000
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 18
NORMAL
Bladder0.00000.00770.0000undef
Breast0.00270.01960.13597.3580
Ovary0.00300.02080.14616.8457
Endocrine tissue0.01820.01091.67450.5972
Gastrointestinal0.00190.0000undef0.0000
Brain0.00510.00990.51611.9377
Hematopoietic0.00280.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00500.00650.76511.3069
Heart0.00850.0000undef0.0000
Testicles0.00000.01170.0000undef
Lungs0.01000.00711.40460.7120
Stomach-esophagus0.00970.0000undef0.0000
Muscle-skeleton0.01880.00603.14060.3184
Kidneys0.00300.0000undef0.0000
Pancreas0.00000.00550.0000undef
Penis0.00900.05330.16855.9360
Prostate0.01910.01061.78980.5587
Uterus0.01160.00711.62460.6155
Breast hyperplasia0.0036
Small intestine0.0062
Prostatic hyperplasia0.0208
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0044
FETUS
Development0.0154
Gastrointestinal0.0062
Brain0.0000
Hematopoietic0.0118
Heart-blood vessels0.0245
Lungs0.0074
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0136
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0082
Gastrointestinal0.0122
Hematopoietic0.0456
Skin-muscle0.0097
Testicles0.0078
Lungs0.0164
Nerves0.0050
Prostate0.0064
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 19
NORMAL
Bladder0.00000.0000undefundef
Breast0.01200.07630.15736.3588
Ovary0.06080.02342.59690.3851
Endocrine tissue0.00730.02450.29773.3593
Gastrointestinal0.08720.10000.87241.1462
Brain0.00170.0000undef0.0000
Hematopoietic0.00140.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.01490.03880.38262.6139
Heart0.00110.0000undef0.0000
Testicles0.00000.0000undefundef
Lungs0.00500.03550.14057.1196
Stomach-esophagus0.00000.02300.0000undef
Muscle-skeleton0.00000.0000undefundef
Kidneys0.00000.0000undefundef
Pancreas0.00000.01660.0000undef
Penis0.00000.0000undefundef
Prostate0.01190.09580.12438.0455
Uterus0.00170.02140.077412.9263
Breast hyperplasia0.0073
Small intestine0.0436
Prostatic hyperplasia0.0119
Seminal vesicles0.0089
Sensory organs0.0470
White blood cells0.0009
FETUS
Development0.0000
Gastrointestinal0.0247
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0205
Endocrine tissue0.0000
Fetal0.0052
Gastrointestinal0.0366
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0000
Prostate0.0321
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 20
NORMAL
Bladder0.00000.00510.0000undef
Breast0.00400.02400.16685.9954
Ovary0.01820.00782.33720.4279
Endocrine tissue0.01640.02450.66981.4930
Gastrointestinal0.02130.01901.11960.8932
Brain0.01440.01860.77411.2918
Hematopoietic0.00560.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.02480.00653.82570.2614
Heart0.01380.0000undef0.0000
Testicles0.04280.0000undef0.0000
Lungs0.01990.01651.20390.8306
Stomach-esophagus0.00970.02300.42002.3811
Muscle-skeleton0.01200.0000undef0.0000
Kidneys0.01190.01370.86831.1517
Pancreas0.00380.0000undef0.0000
Penis0.01500.0000undef0.0000
Prostate0.01190.01920.62151.6091
Uterus0.01320.01420.92831.0772
Breast hyperplasia0.0254
Small intestine0.0093
Prostatic hyperplasia0.0238
Seminal vesicles0.0178
Sensory organs0.0118
White blood cells0.0044
FETUS
Development0.0000
Gastrointestinal0.0062
Brain0.0125
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0111
Kidneys0.0185
Prostate0.0000
Sensory organs0.0140
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0068
Endocrine tissue0.0000
Fetal0.0058
Gastrointestinal0.0488
Hematopoietic0.0114
Skin-muscle0.0065
Testicles0.0000
Lungs0.0000
Nerves0.0040
Prostate0.0385
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 21
NORMAL
Bladder0.00000.00260.0000undef
Breast0.00670.02610.25483.9243
Ovary0.00000.0000undefundef
Endocrine tissue0.00180.0000undef0.0000
Gastrointestinal0.00390.00480.81431.2281
Brain0.00170.00220.77411.2918
Hematopoietic0.01120.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.00000.00650.0000undef
Heart0.00420.01370.30833.2436
Testicles0.00000.0000undefundef
Lungs0.00370.00241.58010.6329
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00340.0000undef0.0000
Kidneys0.00300.01370.21714.6066
Pancreas0.00000.00550.0000undef
Penis0.00600.0000undef0.0000
Prostate0.00240.0000undef0.0000
Uterus0.00170.0000undef0.0000
Breast hyperplasia0.0073
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0052
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0039
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0068
Ovary-uterus0.0046
Endocrine tissue0.0000
Fetal0.0023
Gastrointestinal0.0000
Hematopoietic0.0228
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0000
Prostate0.0064
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 22
NORMAL
Bladder0.00460.00510.90921.0998
Breast0.00930.02180.42812.3359
Ovary0.00610.00780.77911.2836
Endocrine tissue0.00550.0000undef0.0000
Gastrointestinal0.00390.0000undef0.0000
Brain0.00590.00331.80620.5536
Hematopoietic0.01260.0000undef0.0000
Skin0.00500.08470.058717.0262
Hepatic0.00500.0000undef0.0000
Heart0.01380.01371.00200.9980
Testicles0.00610.0000undef0.0000
Lungs0.01120.00244.74040.2110
Stomach-esophagus0.00970.05370.18005.5559
Muscle-skeleton0.00860.01800.47582.1015
Kidneys0.01190.02740.43422.3033
Pancreas0.00570.0000undef0.0000
Penis0.00300.02670.11238.9040
Prostate0.01430.00433.35590.2980
Uterus0.00330.00710.46422.1544
Breast hyperplasia0.0036
Small intestine0.0062
Prostatic hyperplasia0.0089
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0070
FETUS
Development0.0000
Gastrointestinal0.0092
Brain0.0125
Hematopoietic0.0157
Heart-blood vessels0.0041
Lungs0.0037
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0114
Endocrine tissue0.0000
Fetal0.0029
Gastrointestinal0.0000
Hematopoietic0.0114
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0020
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 23
NORMAL
Bladder0.00000.00770.0000undef
Breast0.00400.01310.30583.2702
Ovary0.00300.0000undef0.0000
Endocrine tissue0.01090.0000undef0.0000
Gastrointestinal0.01360.00482.84990.3509
Brain0.00590.00990.60211.6609
Hematopoietic0.00560.0000undef0.0000
Skin0.05970.0000undef0.0000
Hepatic0.00000.00650.0000undef
Heart0.00640.01370.46242.1624
Testicles0.00000.03510.0000undef
Lungs0.00120.00950.13177.5943
Stomach-esophagus0.01930.02300.83991.1905
Muscle-skeleton0.00690.00601.14200.8756
Kidneys0.00590.00680.86831.1517
Pancreas0.00380.0000undef0.0000
Penis0.00000.0000undefundef
Prostate0.01430.02130.67121.4899
Uterus0.00660.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0093
Prostatic hyperplasia0.0089
Seminal vesicles0.0178
Sensory organs0.0118
White blood cells0.0044
FETUS
Development0.0154
Gastrointestinal0.0031
Brain0.0250
Hematopoietic0.0000
Heart-blood vessels0.0245
Lungs0.0037
Kidneys0.0185
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0136
Ovary-uterus0.0297
Endocrine tissue0.0000
Fetal0.0222
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0082
Nerves0.0030
Prostate0.0064
Sensory organs0.0077
Electronic Northern for SEQ. ID NO.: 24
NORMAL
Bladder0.00460.01020.45462.1996
Breast0.00270.01740.15296.5404
Ovary0.01520.02340.64921.5403
Endocrine tissue0.01460.03270.44652.2395
Gastrointestinal0.02910.00953.05350.3275
Brain0.02030.02520.80781.2380
Hematopoietic0.00840.0000undef0.0000
Skin0.01490.0000undef0.0000
Lungs0.01370.01181.15880.8630
Stomach-esophagus0.00970.01530.63001.5874
Muscle-skeleton0.02060.00603.42610.2919
Kidneys0.03270.04110.79601.2563
Pancreas0.01140.02210.51431.9446
Penis0.03290.0000undef0.0000
Prostate0.02860.02341.22030.8195
Uterus0.01650.00712.32080.4309
Breast hyperplasia0.0145
Small intestine0.0187
Prostatic hyperplasia0.0119
Seminal vesicles0.0178
Sensory organs0.0000
White blood cells0.0122
FETUS
Development0.0000
Gastrointestinal0.0154
Brain0.0313
Hematopoietic0.0039
Heart-blood vessels0.0368
Lungs0.0111
Kidneys0.0124
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0228
Endocrine tissue0.0245
Fetal0.0035
Gastrointestinal0.0244
Hematopoietic0.0171
Skin-muscle0.0000
Testicles0.0156
Lungs0.0246
Nerves0.0090
Prostate0.0192
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 25
NORMAL
Bladder0.00000.00510.0000undef
Breast0.00400.01310.30583.2702
Ovary0.00000.00520.0000undef
Endocrine tissue0.00360.00271.33960.7465
Gastrointestinal0.00390.00480.81431.2281
Brain0.01020.00771.32700.7536
Hematopoietic0.00840.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.0000undefundef
Heart0.00000.01370.0000undef
Testicles0.00000.0000undefundef
Lungs0.00120.00470.26343.7971
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00340.02400.14287.0051
Kidneys0.00590.00680.86831.1517
Pancreas0.00000.0000undefundef
Penis0.00300.02670.11238.9040
Prostate0.00000.00640.0000undef
Uterus0.00170.00710.23214.3088
Breast hyperplasia0.0036
Small intestine0.0062
Prostatic hyperplasia0.0059
Seminal vesicles0.0000
Sensory organs0.0118
White blood cells0.0026
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0111
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0000
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0040
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 27
NORMAL
Bladder0.00930.00771.21230.8249
Breast0.00670.01310.50961.9621
Ovary0.00000.0000undefundef
Endocrine tissue0.00180.0000undef0.0000
Gastrointestinal0.00190.0000undef0.0000
Brain0.00420.01750.24194.1338
Hematopoietic0.00280.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.00000.0000undefundef
Heart0.00640.04120.15416.4872
Testicles0.00610.0000undef0.0000
Lungs0.00620.0000undef0.0000
Stomach-esophagus0.00000.01530.0000undef
Muscle-skeleton0.00170.01200.14287.0051
Kidneys0.00890.0000undef0.0000
Pancreas0.00380.0000undef0.0000
Penis0.00000.02670.0000undef
Prostate0.00950.00214.47450.2235
Uterus0.00330.01420.23214.3088
Breast hyperplasia0.0036
Small intestine0.0000
Prostatic hyperplasia0.0030
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0009
FETUS
Development0.0307
Gastrointestinal0.0062
Brain0.0250
Hematopoietic0.0197
Heart-blood vessels0.0000
Lungs0.0185
Kidneys0.0062
Prostate0.0249
Sensory organs0.0558
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0068
Ovary-uterus0.0091
Endocrine tissue0.0000
Fetal0.0012
Gastrointestinal0.0244
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0082
Nerves0.0070
Prostate0.0064
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 29
NORMAL
Bladder0.00000.01020.0000undef
Breast0.00130.01090.12238.1755
Ovary0.00300.00520.58431.7114
Endocrine tissue0.00360.00820.44652.2395
Gastrointestinal0.00580.0000undef0.0000
Brain0.00250.03070.082912.0569
Hematopoietic0.01400.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.00500.0000undef0.0000
Heart0.00000.0000undefundef
Testicles0.00000.02340.0000undef
Lungs0.00370.0000undef0.0000
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00510.00600.85651.1675
Kidneys0.00000.02050.0000undef
Pancreas0.00380.0000undef0.0000
Penis0.00000.0000undefundef
Prostate0.00710.00431.67790.5960
Uterus0.00330.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0062
Prostatic hyperplasia0.0059
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0226
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0000
Hematopoietic0.0197
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0204
Ovary-uterus0.0023
Endocrine tissue0.0000
Fetal0.0023
Gastrointestinal0.0000
Hematopoietic0.0114
Skin-muscle0.0000
Testicles0.0000
Lungs0.0164
Nerves0.0030
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 30
NORMAL
Bladder0.01860.01531.21230.8249
Breast0.01330.04360.30583.2702
Ovary0.01820.01301.40230.7131
Endocrine tissue0.00730.01910.38272.6128
Gastrointestinal0.01940.00952.03570.4912
Brain0.02370.04490.52871.8916
Hematopoietic0.00980.0000undef0.0000
Skin0.00990.0000undef0.0000
Hepatic0.00500.00650.76511.3069
Heart0.02540.05500.46242.1624
Testicles0.02440.0000undef0.0000
Lungs0.02240.01651.35440.7383
Stomach-esophagus0.00000.03070.0000undef
Muscle-skeleton0.00860.01800.47582.1015
Kidneys0.02080.02051.01300.9871
Pancreas0.01140.03870.29393.4030
Penis0.01200.02670.44922.2260
Prostate0.02140.01281.67790.5960
Uterus0.00660.01420.46422.1544
Breast hyperplasia0.0073
Small intestine0.0031
Prostatic hyperplasia0.0059
Seminal vesicles0.0000
Sensory organs0.0118
White blood cells0.0305
FETUS
Development0.1537
Gastrointestinal0.0401
Brain0.1126
Hematopoietic0.0472
Heart-blood vessels0.0164
Lungs0.0481
Kidneys0.0247
Prostate0.0499
Sensory organs0.1954
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0544
Ovary-uterus0.0320
Endocrine tissue0.0000
Fetal0.0636
Gastrointestinal0.0610
Hematopoietic0.0057
Skin-muscle0.1328
Testicles0.0000
Lungs0.0082
Nerves0.0191
Prostate0.0064
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 31
NORMAL
Bladder0.00460.00261.81850.5499
Breast0.00270.01090.24464.0878
Ovary0.00000.00780.0000undef
Endocrine tissue0.00180.00540.33492.9861
Gastrointestinal0.00780.00481.62850.6141
Brain0.02630.01102.39970.4167
Hematopoietic0.00420.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.00990.0000undef0.0000
Heart0.00640.02750.23124.3248
Testicles0.00000.01170.0000undef
Lungs0.01120.00472.37020.4219
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00510.00600.85651.1675
Kidneys0.00890.0000undef0.0000
Pancreas0.00570.0000undef0.0000
Penis0.01500.0000undef0.0000
Prostate0.00480.00640.74581.3409
Uterus0.00000.0000undefundef
Breast hyperplasia0.0036
Small intestine0.0125
Prostatic hyperplasia0.0059
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0044
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0063
Hematopoietic0.0079
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0249
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0136
Ovary-uterus0.0091
Endocrine tissue0.0000
Fetal0.0047
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0227
Testicles0.0000
Lungs0.0246
Nerves0.0231
Prostate0.0064
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 33
NORMAL
Bladder0.01390.02300.60621.6497
Breast0.00130.01310.10199.8107
Ovary0.00610.00780.77911.2836
Endocrine tissue0.01280.00274.68850.2133
Gastrointestinal0.01740.00483.66420.2729
Brain0.00850.01420.59551.6794
Hematopoietic0.00560.0000undef0.0000
Skin0.02490.0000undef0.0000
Hepatic0.00000.02590.0000undef
Heart0.01590.01371.15610.8650
Testicles0.00000.0000undefundef
Lungs0.02240.02600.86191.1602
Stomach-esophagus0.00970.0000undef0.0000
Muscle-skeleton0.01540.00602.56960.3892
Kidneys0.01490.01371.08540.9213
Pancreas0.00380.01100.34282.9168
Penis0.01200.02670.44922.2260
Prostate0.01910.02550.74581.3409
Uterus0.01320.00711.85670.5386
Breast hyperplasia0.0145
Small intestine0.0093
Prostatic hyperplasia0.0208
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0183
FETUS
Development0.0000
Gastrointestinal0.0123
Brain0.0063
Hematopoietic0.0000
Heart-blood vessels0.0041
Lungs0.0037
Kidneys0.0124
Prostate0.0748
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0204
Ovary-uterus0.0091
Endocrine tissue0.0000
Fetal0.0070
Gastrointestinal0.0366
Hematopoietic0.0114
Skin-muscle0.0356
Testicles0.0000
Lungs0.0164
Nerves0.0010
Prostate0.0128
Sensory organs0.0155
Electronic Northern for SEQ. ID NO.: 35
NORMAL
Bladder0.01390.0000undef0.0000
Breast0.00130.01090.12238.1755
Ovary0.00910.00781.16860.8557
Endocrine tissue0.01280.00821.56280.6399
Gastrointestinal0.00970.00951.01780.9825
Brain0.00680.00661.03210.9689
Hematopoietic0.00280.0000undef0.0000
Skin0.00990.0000undef0.0000
Hepatic0.02480.0000undef0.0000
Heart0.00530.0000undef0.0000
Testicles0.00000.0000undefundef
Lungs0.00370.00950.39502.5314
Stomach-esophagus0.00000.01530.0000undef
Muscle-skeleton0.00690.00601.14200.8756
Kidneys0.01490.00682.17080.4607
Pancreas0.00570.00551.02850.9723
Penis0.01200.0000undef0.0000
Prostate0.00480.00640.74581.3409
Uterus0.00170.00710.23214.3088
Breast hyperplasia0.0000
Small intestine0.0093
Prostatic hyperplasia0.0059
Seminal vesicles0.0089
Sensory organs0.0118
White blood cells0.0017
FETUS
Development0.0154
Gastrointestinal0.0062
Brain0.0063
Hematopoietic0.0000
Heart-blood vessels0.0041
Lungs0.0074
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0068
Ovary-uterus0.0091
Endocrine tissue0.0000
Fetal0.0111
Gastrointestinal0.0122
Hematopoietic0.0057
Skin-muscle0.0453
Testicles0.0078
Lungs0.0000
Nerves0.0100
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 36
NORMAL
Bladder0.00000.00260.0000undef
Breast0.00130.01090.12238.1755
Ovary0.00000.0000undefundef
Endocrine tissue0.00000.00270.0000undef
Gastrointestinal0.00190.0000undef0.0000
Brain0.00510.00114.64460.2153
Hematopoietic0.00420.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.00650.0000undef
Heart0.00000.0000undefundef
Testicles0.00000.0000undefundef
Lungs0.00000.0000undefundef
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00340.0000undef0.0000
Kidneys0.00000.0000undefundef
Pancreas0.00000.0000undefundef
Penis0.00000.0000undefundef
Prostate0.00480.00212.23730.4470
Uterus0.00000.0000undefundef
Breast hyperplasia0.0000
Small intestine0.0000
Prostatic hyperplasia0.0059
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0026
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0125
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0062
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0114
Endocrine tissue0.0000
Fetal0.0017
Gastrointestinal0.0122
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0020
Prostate0.0064
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 37
NORMAL
Bladder0.00460.01020.45462.1996
Breast0.00000.02180.0000undef
Ovary0.01220.04420.27503.6368
Endocrine tissue0.00000.00270.0000undef
Gastrointestinal0.01360.01900.71251.4035
Brain0.00080.00770.11069.0427
Hematopoietic0.03220.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.00000.01290.0000undef
Heart0.00210.0000undef0.0000
Testicles0.00000.02340.0000undef
Lungs0.05350.04731.13240.8831
Stomach-esophagus0.06760.07670.88191.1339
Muscle-skeleton0.00860.0000undef0.0000
Kidneys0.00000.00680.0000undef
Pancreas0.01140.00552.05700.4861
Penis0.00300.0000undef0.0000
Prostate0.00710.01280.55931.7879
Uterus0.00170.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0249
Prostatic hyperplasia0.0030
Seminal vesicles0.0000
Sensory organs0.0235
White blood cells0.1140
FETUS
Development0.0154
Gastrointestinal0.0154
Brain0.0000
Hematopoietic0.0039
Heart-blood vessels0.0041
Lungs0.0037
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0029
Gastrointestinal0.0366
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0082
Nerves0.0000
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 38
NORMAL
Bladder0.00000.00260.0000undef
Breast0.00670.01310.50961.9621
Ovary0.00610.0000undef0.0000
Endocrine tissue0.00360.0000undef0.0000
Gastrointestinal0.00190.0000undef0.0000
Brain0.00000.00330.0000undef
Hematopoietic0.00840.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.0000undefundef
Heart0.00210.0000undef0.0000
Testicles0.00000.0000undefundef
Lungs0.00000.0000undefundef
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00000.0000undefundef
Kidneys0.01190.0000undef0.0000
Pancreas0.00000.0000undefundef
Penis0.00000.0000undefundef
Prostate0.00240.00430.55931.7879
Uterus0.00170.0000undef0.0000
Breast hyperplasia0.0073
Small intestine0.0031
Prostatic hyperplasia0.0030
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0026
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0124
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0046
Endocrine tissue0.0490
Fetal0.0029
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0082
Nerves0.0131
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 39
NORMAL
Bladder0.00930.00771.21230.8249
Breast0.00530.02830.18825.3141
Ovary0.01220.01300.93491.0696
Endocrine tissue0.03470.03001.15690.8644
Gastrointestinal0.01360.0000undef0.0000
Brain0.01530.01311.16120.8612
Hematopoietic0.00560.0000undef0.0000
Skin0.01990.0000undef0.0000
Hepatic0.01980.00653.06060.3267
Heart0.01270.01370.92491.0812
Testicles0.01220.01171.04470.9572
Lungs0.02120.01651.27920.7818
Stomach-esophagus0.01930.0000undef0.0000
Muscle-skeleton0.01200.01800.66621.5011
Kidneys0.00300.0000undef0.0000
Pancreas0.01330.0000undef0.0000
Penis0.00300.05330.056217.8081
Prostate0.01670.00642.61010.3831
Uterus0.00660.00710.92831.0772
Breast hyperplasia0.0073
Small intestine0.0125
Prostatic hyperplasia0.0208
Seminal vesicles0.0000
Sensory organs0.0353
White blood cells0.0235
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0000
Hematopoietic0.0079
Heart-blood vessels0.0041
Lungs0.0111
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0068
Ovary-uterus0.0274
Endocrine tissue0.0000
Fetal0.0204
Gastrointestinal0.0244
Hematopoietic0.0000
Skin-muscle0.0421
Testicles0.0000
Lungs0.0164
Nerves0.0151
Prostate0.0256
Sensory organs0.0542
Electronic Northern for SEQ. ID NO.: 40
NORMAL
Bladder0.00000.0000undefundef
Breast0.00270.01740.15296.5404
Ovary0.00000.0000undefundef
Endocrine tissue0.00000.00820.0000undef
Gastrointestinal0.00000.00480.0000undef
Brain0.00760.0000undef0.0000
Hematopoietic0.00280.0000undef0.0000
Skin0.01490.0000undef0.0000
Hepatic0.00500.0000undef0.0000
Heart0.00210.0000undef0.0000
Testicles0.00610.0000undef0.0000
Lungs0.00870.0000undef0.0000
Stomach-esophagus0.00970.0000undef0.0000
Muscle-skeleton0.00510.0000undef0.0000
Kidneys0.00000.0000undefundef
Pancreas0.00000.0000undefundef
Penis0.00600.0000undef0.0000
Prostate0.00240.00211.11860.8939
Uterus0.00170.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0031
Prostatic hyperplasia0.0030
Seminal vesicles0.0178
Sensory organs0.0000
White blood cells0.0070
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0245
Fetal0.0117
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0082
Nerves0.0070
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 41
NORMAL
Bladder0.00000.01280.0000undef
Breast0.00400.02180.18355.4504
Ovary0.00000.00260.0000undef
Endocrine tissue0.00180.0000undef0.0000
Gastrointestinal0.00580.00950.61071.6375
Brain0.00000.00330.0000undef
Hematopoietic0.00560.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.0000undefundef
Heart0.00320.0000undef0.0000
Testicles0.00000.0000undefundef
Lungs0.00120.00470.26343.7971
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00340.0000undef0.0000
Kidneys0.00000.0000undefundef
Pancreas0.00000.00550.0000undef
Penis0.00300.0000undef0.0000
Prostate0.00480.00212.23730.4470
Uterus0.00500.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0031
Prostatic hyperplasia0.0000
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0061
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0185
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0006
Gastrointestinal0.0000
Hematopoietic0.0228
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0000
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 42
NORMAL
Bladder0.00000.00510.0000undef
Breast0.00530.01090.48932.0439
Ovary0.00300.00520.58431.7114
Endocrine tissue0.00000.00270.0000undef
Gastrointestinal0.00000.0000undefundef
Brain0.00000.0000undefundef
Hematopoietic0.00000.0000undefundef
Skin0.00000.0000undefundef
Hepatic0.00500.0000undef0.0000
Heart0.00000.0000undefundef
Testicles0.00000.0000undefundef
Lungs0.00500.00242.10690.4746
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00000.0000undefundef
Kidneys0.00000.0000undefundef
Pancreas0.00000.0000undefunuef
Penis0.00000.0000undefundef
Prostate0.00480.0000undef0.0000
Uterus0.00000.0000undefundef
Breast hyperplasia0.0036
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0000
Sensory organs0.0235
White blood cells0.0000
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0340
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0146
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0130
Testicles0.0000
Lungs0.0082
Nerves0.0181
Prostate0.0000
Sensory organs0.0077
Electronic Northern for SEQ. ID NO.: 43
NORMAL
Bladder0.00000.00260.0000undef
Breast0.00130.01090.12238.1755
Ovary0.00300.0000undef0.0000
Endocrine tissue0.00180.0000undef0.0000
Gastrointestinal0.00000.0000undefundef
Brain0.00080.0000undef0.0000
Hematopoietic0.00000.0000undefundef
Skin0.00000.0000undefundef
Hepatic0.00000.0000undefundef
Heart0.00000.0000undefundef
Testicles0.00000.0000undefundef
Lungs0.00000.00240.0000undef
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00000.0000undefundef
Kidneys0.00300.0000undef0.0000
Pancreas0.00000.0000undefundef
Penis0.00000.02670.0000undef
Prostate0.00000.0000undefundef
Uterus0.00170.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0000
Sensory organs0.0118
White blood cells0.0000
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0029
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0010
Prostate0.0064
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 44
NORMAL
Bladder0.00000.0000undefundef
Breast0.00130.01530.087411.4458
Ovary0.00000.00520.0000undef
Endocrine tissue0.00000.0000undefundef
Gastrointestinal0.00000.00480.0000undef
Brain0.00000.0000undefunaef
Hematopoietic0.00000.0000undefundef
Skin0.00000.0000undefundef
Hepatic0.00000.0000undefundef
Heart0.00000.0000undefundef
Testicles0.00000.0000undefundef
Lungs0.00120.0000undef0.0000
Stomach-esophagus0.01930.0000undef0.0000
Muscle-skeleton0.00000.0000undefundef
Kidneys0.00000.0000undefundef
Pancreas0.00000.0000undefundef
Penis0.00600.0000undef0.0000
Prostate0.00000.0000undefundef
Uterus0.00000.0000undefundef
Breast hyperplasia0.0000
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0000
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0039
Heart-blood vessels0.0041
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0023
Endocrine tissue0.0000
Fetal0.0000
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0010
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 45
NORMAL
Bladder0.01390.0000undef0.0000
Breast0.00930.01960.47572.1023
Ovary0.01220.00781.55820.6418
Endocrine tissue0.00360.00540.66981.4930
Gastrointestinal0.00970.0000undef0.0000
Brain0.01100.01310.83861.1924
Hematopoietic0.00280.03780.073913.5274
Skin0.03480.0000undef0.0000
Hepatic0.00990.0000undef0.0000
Heart0.01060.0000undef0.0000
Testicles0.00610.01170.52241.9144
Lungs0.01120.00951.18510.8438
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00510.00600.85651.1675
Kidneys0.00890.00681.30250.7678
Pancreas0.01330.00552.39990.4167
Penis0.00900.0000undef0.0000
Prostate0.00950.00432.23730.4470
Uterus0.00660.00710.92831.0772
Breast hperplasia0.0109
Small intestine0.0062
Prostatic hyperplasia0.0030
Seminal vesicles0.0089
Sensory organs0.0235
White blood cells0.0078
FETUS
Development0.0154
Gastrointestinal0.0092
Brain0.0125
Hematopoietic0.0000
Heart-blood vessels0.0082
Lungs0.0296
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0046
Endocrine tissue0.0000
Fetal0.0210
Gastrointestinal0.0122
Hematopoietic0.0114
Skin-muscle0.0032
Testicles0.0000
Lungs0.0164
Nerves0.0131
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 46
NORMAL
Bladder0.02320.00514.54620.2200
Breast0.00270.01530.17475.7229
Ovary0.00300.00780.38952.5671
Endocrine tissue0.00000.00540.0000undef
Gastrointestinal0.00190.00950.20364.9124
Brain0.00760.00990.77411.2918
Hematopoietic0.00280.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00500.00650.76511.3069
Heart0.00530.05500.096310.3795
Testicles0.01220.01171.04470.9572
Lungs0.00370.00710.52671.8986
Stomach-esophagus0.02900.00773.77980.2646
Muscle-skeleton0.00170.0000undef0.0000
Kidneys0.00890.00681.30250.7678
Pancreas0.00760.00551.37130.7292
Penis0.00300.0000undef0.0000
Prostate0.00240.01060.22374.4697
Uterus0.00830.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0062
Prostatic hyperplasia0.0089
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0017
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0063
Hematopoietic0.0000
Heart-blood vessels0.0041
Lungs0.0074
Kidneys0.0247
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0068
Endocrine tissue0.0000
Fetal0.0017
Gastrointestinal0.0122
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0082
Nerves0.0020
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 47
NORMAL
Bladder0.00000.00510.0000undef
Breast0.00130.01310.10199.8107
Ovary0.00300.00520.58431.7114
Endocrine tissue0.00550.0000undef0.0000
Gastrointestinal0.00000.0000undefundef
Brain0.00680.00551.23860.8074
Hematopoietic0.00420.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00990.0000undef0.0000
Heart0.00320.0000undef0.0000
Testicles0.00000.0000undefundef
Lungs0.00000.00470.0000undef
Stomach-esophagus0.00000.01530.0000undef
Muscle-skeleton0.00340.0000undef0.0000
Kidneys0.00890.00681.30250.7678
Pancreas0.00000.0000undefundef
Penis0.00300.0000undef0.0000
Prostate0.00000.00850.0000undef
Uterus0.00330.0000undef0.0000
Breast hyperplasia0.0073
Small intestine0.0062
Prostatic hyperplasia0.0059
Seminal vesicles0.0178
Sensory organs0.0000
White blood cells0.0009
FETUS
Development0.0154
Gastrointestinal0.0031
Brain0.0063
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0062
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0023
Endocrine tissue0.0000
Fetal0.0023
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0065
Testicles0.0000
Lungs0.0082
Nerves0.0000
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 48
NORMAL
Bladder0.00930.00511.81850.5499
Breast0.00530.01960.27183.6790
Ovary0.00610.00521.16860.8557
Endocrine tissue0.00730.01090.66981.4930
Gastrointestinal0.00970.01430.67861.4737
Brain0.00590.00222.70940.3691
Hematopoietic0.00420.03780.11099.0183
Skin0.00500.0000undef0.0000
Hepatic0.00000.00650.0000undef
Heart0.01380.0000undef0.0000
Testicles0.01220.02340.52241.9144
Lungs0.00120.00710.17565.6957
Stomach-esophagus0.02900.0000undef0.0000
Muscle-skeleton0.00510.01200.42832.3350
Kidneys0.00000.0000undefundef
Pancreas0.00950.0000undef0.0000
Penis0.01500.0000undef0.0000
Prostate0.00480.00850.55931.7879
Uterus0.00500.00710.69631.4363
Breast hyperplasia0.0000
Small intestine0.0093
Prostatic hyperplasia0.0089
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0044
FETUS
Development0.0307
Gastrointestinal0.0062
Brain0.0063
Hematopoietic0.0118
Heart-blood vessels0.0164
Lungs0.0148
Kidneys0.0062
Prostate0.0499
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0137
Endocrine tissue0.0000
Fetal0.0187
Gastrointestinal0.0244
Hematopoietic0.0000
Skin-muscle0.0194
Testicles0.0156
Lungs0.0000
Nerves0.0131
Prostate0.0321
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 49
NORMAL
Bladder0.00000.00770.0000undef
Breast0.00400.01530.26213.8153
Ovary0.00910.02860.31873.1376
Endocrine tissue0.01820.03270.55821.7916
Gastrointestinal0.01550.00951.62850.6141
Brain0.01270.00991.29020.7751
Hematopoietic0.00980.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00990.0000undef0.0000
Heart0.02650.02750.96341.0380
Testicles0.00610.01170.52241.9144
Lungs0.01490.02600.57461.7403
Stomach-esophagus0.00970.00771.25990.7937
Muscle-skeleton0.01030.00601.71300.5838
Kidneys0.02080.03420.60781.6452
Pancreas0.00190.00550.34282.9168
Penis0.00600.0000undef0.0000
Prostate0.00240.01060.22374.4697
Uterus0.00990.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0093
Prostatic hyperplasia0.0059
Seminal vesicles0.0178
Sensory organs0.0118
White blood cells0.0052
FETUS
Development0.0000
Gastrointestinal0.0062
Brain0.0125
Hematopoietic0.0236
Heart-blood vessels0.0286
Lungs0.0074
Kidneys0.0062
Prostate0.0000
Sensory organs0.0279
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0114
Endocrine tissue0.0000
Fetal0.0210
Gastrointestinal0.0244
Hematopoietic0.0000
Skin-muscle0.0421
Testicles0.0000
Lungs0.0164
Nerves0.0050
Prostate0.0064
Sensory organs0.0155
Electronic Northern for SEQ. ID NO.: 50
NORMAL
Bladder0.00000.01790.0000undef
Breast0.00130.00650.20394.9053
Ovary0.00000.0000undefundef
Endocrine tissue0.00180.0000undef0.0000
Gastrointestinal0.00190.0000undef0.0000
Brain0.00080.00220.38712.5836
Hematopoietic0.00140.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00500.0000undef0.0000
Heart0.00320.0000undef0.0000
Testicles0.00000.0000undefundef
Lungs0.00120.00470.26343.7971
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00170.00600.28553.5025
Kidneys0.00000.0000undefundef
Pancreas0.00000.00550.0000undef
Penis0.00000.0000undefundef
Prostate0.00000.0000undefundef
Uterus0.00830.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0009
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0046
Endocrine tissue0.0000
Fetal0.0064
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0065
Testicles0.0000
Lungs0.0164
Nerves0.0040
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 51
NORMAL
Bladder0.00000.00510.0000undef
Breast0.00530.01530.34952.8614
Ovary0.02130.02340.90891.1002
Endocrine tissue0.01820.05180.35252.8368
Gastrointestinal0.00780.00481.62850.6141
Brain0.01360.01201.12600.8881
Hematopoietic0.00980.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.01940.0000undef
Heart0.00950.0000undef0.0000
Testicles0.04280.01173.65650.2735
Lungs0.01370.01420.96561.0356
Stomach-esophagus0.00970.0000undef0.0000
Muscle-skeleton0.00170.06000.028635.0255
Kidneys0.01780.04790.37212.6872
Pancreas0.01700.0000undef0.0000
Penis0.01500.0000undef0.0000
Prostate0.00710.03830.18645.3637
Uterus0.00660.00710.92831.0772
Breast hyperplasia0.0218
Small intestine0.0000
Prostatic hyperplasia0.0208
Seminal vesicles0.0089
Sensory organs0.0353
White blood cells0.0218
FETUS
Development0.0154
Gastrointestinal0.0123
Brain0.0000
Hematopoietic0.0039
Heart-blood vessels0.0164
Lungs0.0037
Kidneys0.0185
Prostate0.0249
Sensory organs0.0140
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0434
Endocrine tissue0.0000
Fetal0.0210
Gastrointestinal0.0366
Hematopoietic0.0000
Skin-muscle0.0972
Testicles0.0468
Lungs0.0082
Nerves0.0151
Prostate0.0321
Sensory organs0.0310
Electronic Northern for SEQ. ID NO.: 52
NORMAL
Bladder0.02320.02560.90921.0998
Breast0.00530.01310.40772.4527
Ovary0.00610.00780.77911.2836
Endocrine tissue0.01090.00542.00930.4977
Gastrointestinal0.00970.0000undef0.0000
Brain0.00420.01310.32253.1004
Hematopoietic0.00980.0000undef0.0000
Skin0.02490.0000undef0.0000
Hepatic0.00000.0000undefundef
Heart0.02010.0000undef0.0000
Testicles0.00000.01170.0000undef
Lungs0.01250.01181.05340.9493
Stomach-esophagus0.03860.01532.51980.3968
Muscle-skeleton0.00340.00600.57101.7513
Kidneys0.01190.01370.86831.1517
Pancreas0.00380.01100.34282.9168
Penis0.00900.05330.16855.9360
Prostate0.01190.01700.69911.4303
Uterus0.00990.01420.69631.4363
Breast hyperplasia0.0073
Small intestine0.0125
Prostatic hyperplasia0.0119
Seminal vesicles0.0178
Sensory organs0.0000
White blood cells0.0052
FETUS
Development0.0307
Gastrointestinal0.0062
Brain0.0063
Hematopoietic0.0236
Heart-blood vessels0.0041
Lungs0.0037
Kidneys0.0000
Prostate0.0748
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0205
Endocrine tissue0.0000
Fetal0.0128
Gastrointestinal0.0244
Hematopoietic0.0057
Skin-muscle0.0130
Testicles0.0078
Lungs0.0000
Nerves0.0030
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 53
NORMAL
Bladder0.00930.00511.81850.5499
Breast0.00530.01530.34952.8614
Ovary0.00000.00260.0000undef
Endocrine tissue0.00180.0000undef0.0000
Gastrointestinal0.00390.01430.27143.6843
Brain0.00340.01640.20644.8443
Hematopoietic0.00280.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.00000.01940.0000undef
Heart0.00320.0000undef0.0000
Testicles0.00610.0000undef0.0000
Lungs0.00750.00471.58010.6329
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00340.01800.19035.2538
Kidneys0.00590.01370.43422.3033
Pancreas0.00190.00550.34282.9168
Penis0.00600.0000undef0.0000
Prostate0.00240.00430.55931.7879
Uterus0.00660.0000undef0.0000
Breast hyperplasia0.0073
Small intestine0.0093
Prostatic hyperplasia0.0030
Seminal vesicles0.0000
Sensory organs0.0118
White blood cells0.0000
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0000
Hematopoietic0.0079
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0062
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0046
Endocrine tissue0.0000
Fetal0.0006
Gastrointestinal0.0000
Hematopoietic0.0057
Skin-muscle0.0097
Testicles0.0000
Lungs0.0082
Nerves0.0050
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 54
NORMAL
Bladder0.01390.01021.36390.7332
Breast0.00800.02180.36692.7252
Ovary0.01220.01820.66781.4975
Endocrine tissue0.01280.01910.66981.4930
Gastrointestinal0.00970.02860.33932.9474
Brain0.00590.01100.54191.8454
Hematopoietic0.02800.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.00000.01290.0000undef
Heart0.01270.0000undef0.0000
Testicles0.01220.01171.04470.9572
Lungs0.01000.00711.40460.7120
Stomach-esophagus0.00000.01530.0000undef
Muscle-skeleton0.02230.0000undef0.0000
Kidneys0.01490.01371.08540.9213
Pancreas0.01330.04420.30003.3335
Penis0.00600.0000undef0.0000
Prostate0.00950.01280.74581.3409
Uterus0.02640.0000undef0.0000
Breast hyperplasia0.0036
Small intestine0.0125
Prostatic hyperplasia0.0238
Seminal vesicles0.0267
Sensory organs0.0118
White blood cells0.0026
FETUS
Development0.0000
Gastrointestinal0.0123
Brain0.0125
Hematopoietic0.0118
Heart-blood vessels0.0000
Lungs0.0111
Kidneys0.0309
Prostate0.0249
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0136
Ovary-uterus0.0274
Endocrine tissue0.0245
Fetal0.0099
Gastrointestinal0.0122
Hematopoietic0.0228
Skin-muscle0.0324
Testicles0.0000
Lungs0.0082
Nerves0.0131
Prostate0.0000
Sensory organs0.0077
Electronic Northern for SEQ. ID NO.: 55
NORMAL
Bladder0.00460.00510.90921.0998
Breast0.00670.01530.43682.2892
Ovary0.00000.01300.0000undef
Endocrine tissue0.00910.01360.66981.4930
Gastrointestinal0.01360.01430.95001.0527
Brain0.01440.00881.64500.6079
Hematopoietic0.00700.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00990.0000undef0.0000
Heart0.00420.01370.30833.2436
Testicles0.00000.01170.0000undef
Lungs0.00620.00950.65841.5189
Stomach-esophagus0.00000.09970.0000undef
Muscle-skeleton0.00170.01800.095210.5076
Kidneys0.01190.01370.86831.1517
Pancreas0.00950.01100.85711.1667
Penis0.01500.0000undef0.0000
Prostate0.00710.01280.55931.7879
Uterus0.00990.00711.39250.7181
Breast hyperplasia0.0036
Small intestine0.0218
Prostatic hyperplasia0.0089
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0070
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0000
Hematopoietic0.0157
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0068
Ovary-uterus0.0068
Endocrine tissue0.0000
Fetal0.0029
Gastrointestinal0.0366
Hematopoietic0.0171
Skin-muscle0.0032
Testicles0.0078
Lungs0.0082
Nerves0.0080
Prostate0.0064
Sensory organs0.0077
Electronic Northern for SEQ. ID NO.: 56
NORMAL
Bladder0.00000.02040.0000undef
Breast0.00000.02180.0000undef
Ovary0.00000.00260.0000undef
Endocrine tissue0.00000.00540.0000undef
Gastrointestinal0.00390.00480.81431.2281
Brain0.00080.00110.77411.2918
Hematopoietic0.00000.0000undefundef
Skin0.00000.0000undefundef
Hepatic0.00000.0000undefundef
Heart0.00000.0000undefundef
Testicles0.00000.0000undefundef
Lungs0.00120.00470.26343.7971
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00000.0000undefundef
Kidneys0.00000.0000undefundef
Pancreas0.00000.01100.0000undef
Penis0.00000.02670.0000undef
Prostate0.00000.0000undefundef
Uterus0.00330.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0009
FETUS
Development0.0000
Gastrointestinal0.0062
Brain0.0000
Hematopoietic0.0079
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0136
Ovary-uterus0.0320
Endocrine tissue0.0000
Fetal0.0367
Gastrointestinal0.0000
Hematopoietic0.0114
Skin-muscle0.0065
Testicles0.0000
Lungs0.0164
Nerves0.0000
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 57
NORMAL
Bladder0.00460.00510.90921.0998
Breast0.00270.01090.24464.0878
Ovary0.00910.00263.50590.2852
Endocrine tissue0.00360.00540.66981.4930
Gastrointestinal0.00190.0000undef0.0000
Brain0.00170.00440.38712.5836
Hematopoietic0.00280.0000undef0.0000
Skin0.00000.08470.0000undef
Hepatic0.00000.0000undefundef
Heart0.00210.0000undef0.0000
Testicles0.00000.0000undefundef
Lungs0.00500.0000undef0.0000
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00170.00600.28553.5025
Kidneys0.00000.0000undefundef
Pancreas0.00570.01100.51431.9446
Penis0.00000.0000undefundef
Prostate0.00000.00210.0000undef
Uterus0.00330.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0031
Prostatic hyperplasia0.0059
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0061
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0000
Hematopoietic0.0079
Heart-blood vessels0.0000
Lungs0.0074
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0000
Gastrointestinal0.0122
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0050
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 58
NORMAL
Bladder0.00000.0000undefundef
Breast0.01730.05230.33133.0187
Ovary0.00000.00260.0000undef
Endocrine tissue0.00180.0000undef0.0000
Gastrointestinal0.00000.0000undefundef
Brain0.00000.0000undefundef
Hematopoietic0.00280.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.00000.0000undefundef
Heart0.00000.0000undefundef
Testicles0.00000.0000undefundef
Lungs0.00000.0000undefundef
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00000.0000undefundef
Kidneys0.00000.0000undefundef
Pancreas0.00000.0000undefundef
Penis0.00000.0000undefundef
Prostate0.00240.0000undef0.0000
Uterus0.00660.02850.23214.3088
Breast hyperplasia0.0073
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0000
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0000
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0000
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 59
NORMAL
Bladder0.00460.00510.90921.0998
Breast0.00130.01090.12238.1755
Ovary0.00610.0000undef0.0000
Endocrine tissue0.00180.0000undef0.0000
Gastrointestinal0.00390.00950.40712.4562
Brain0.00250.00660.38712.5836
Hematopoietic0.00000.0000undefundef
Skin0.00000.0000undefundef
Hepatic0.00000.00650.0000undef
Heart0.00740.0000undef0.0000
Testicles0.00610.02340.26123.8288
Lungs0.00250.00950.26343.7971
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00170.0000undef0.0000
Kidneys0.00300.00680.43422.3033
Pancreas0.00000.00550.0000undef
Penis0.00600.0000undef0.0000
Prostate0.00240.0000undef0.0000
Uterus0.00170.0000undef0.0000
Breast hyperplasia0.0073
Small intestine0.0031
Prostatic hyperplasia0.0089
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0009
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0082
Lungs0.0037
Kidneys0.0185
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0068
Ovary-uterus0.0160
Endocrine tissue0.0245
Fetal0.0035
Gastrointestinal0.0000
Hematopoietic0.0114
Skin-muscle0.0000
Testicles0.0000
Lungs0.0000
Nerves0.0020
Prostate0.0064
Sensory organs0.0155
Electronic Northern for SEQ. ID NO.: 61
NORMAL
Bladder0.00000.0000undefundef
Breast0.00130.01090.12238.1755
Ovary0.00000.0000undefundef
Endocrine tissue0.00910.02450.37212.6874
Gastrointestinal0.00000.0000undefundef
Brain0.00170.00220.77411.2918
Hematopoietic0.00140.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.0000undefundef
Heart0.00320.0000undef0.0000
Testicles0.00610.0000undef0.0000
Lungs0.00500.00242.10690.4746
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00340.0000undef0.0000
Kidneys0.00300.0000undef0.0000
Pancreas0.00000.00550.0000undef
Penis0.00300.0000undef0.0000
Prostate0.00240.00850.27973.5758
Uterus0.00000.0000undefundef
Breast hyperplasia0.0000
Small intestine0.0031
Prostatic hyperplasia0.0059
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0000
FETUS
Development0.0000
Gastrointestinal0.0031
Brain0.0000
Hematopoietic0.0157
Heart-blood vessels0.0041
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0068
Endocrine tissue0.0000
Fetal0.0128
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0162
Testicles0.0000
Lungs0.0082
Nerves0.0020
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 62
NORMAL
Bladder0.00000.00510.0000undef
Breast0.00800.01530.52421.9076
Ovary0.00910.00781.16860.8557
Endocrine tissue0.00550.01090.50231.9907
Gastrointestinal0.00780.02380.32573.0703
Brain0.00510.00770.66351.5071
Hematopoietic0.01400.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00990.0000undef0.0000
Heart0.00000.0000undefundef
Testicles0.00610.0000undef0.0000
Lungs0.00500.00471.05340.9493
Stomach-esophagus0.00000.00770.0000undef
Muscle-skeleton0.00170.0000undef0.0000
Kidneys0.00590.00680.86831.1517
Pancreas0.00190.0000undef0.0000
Penis0.00300.0000undef0.0000
Prostate0.00480.00212.23730.4470
Uterus0.00330.02140.15476.4632
Breast hyperplasia0.0000
Small intestine0.0031
Prostatic hyperplasia0.0119
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0035
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0063
Hematopoietic0.0079
Heart-blood vessels0.0041
Lungs0.0074
Kidneys0.0185
Prostate0.0000
Sensory organs0.0140
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0091
Endocrine tissue0.0000
Fetal0.0087
Gastrointestinal0.0244
Hematopoietic0.0057
Skin-muscle0.0097
Testicles0.0156
Lungs0.0000
Nerves0.0030
Prostate0.0000
Sensory organs0.0697
Electronic Northern for SEQ. ID NO.: 63
NORMAL
Bladder0.00460.0000undef0.0000
Breast0.00000.01090.0000undef
Ovary0.00300.00261.16860.8557
Endocrine tissue0.00180.00270.66981.4930
Gastrointestinal0.00390.0000undef0.0000
Brain0.00340.00440.77411.2918
Hematopoietic0.00420.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.01490.0000undef0.0000
Heart0.00110.0000undef0.0000
Testicles0.00000.0000undefundef
Lungs0.00120.0000undef0.0000
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00170.00600.28553.5025
Kidneys0.00590.0000undef0.0000
Pancreas0.00190.00550.34282.9168
Penis0.00600.0000undef0.0000
Prostate0.00000.0000undefundef
Uterus0.00330.0000undef0.0000
Breast hyperplasia0.0036
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0089
Sensory organs0.0000
White blood cells0.0026
FETUS
Development0.0000
Gastrointestinal0.0092
Brain0.0125
Hematopoietic0.0039
Heart-blood vessels0.0082
Lungs0.0000
Kidneys0.0062
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0046
Endocrine tissue0.0490
Fetal0.0058
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0065
Testicles0.0000
Lungs0.0000
Nerves0.0010
Prostate0.0000
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 64
NORMAL
Bladder0.00460.06650.069914.2976
Breast0.00800.04360.18355.4504
Ovary0.00610.02340.25973.8507
Endocrine tissue0.00000.0000undefundef
Gastrointestinal0.02130.05710.37322.6795
Brain0.00080.0000undef0.0000
Hematopoietic0.00280.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.01940.0000undef
Heart0.00000.0000undefundef
Testicles0.00000.0000undefundef
Lungs0.00870.01420.61451.6273
Stomach-esophagus0.02900.0000undef0.0000
Muscle-skeleton0.00000.0000undefundef
Kidneys0.01190.02050.57891.7275
Pancreas0.01330.02760.48002.0835
Penis0.00000.0000undefundef
Prostate0.01190.01061.11860.8939
Uterus0.00330.00710.46422.1544
Breast hyperplasia0.0073
Small intestine0.0343
Prostatic hyperplasia0.0208
Seminal vesicles0.0178
Sensory organs0.0353
White blood cells0.0000
FETUS
Development0.0000
Gastrointestinal0.0092
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0037
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0476
Ovary-uterus0.0274
Endocrine tissue0.0000
Fetal0.0052
Gastrointestinal0.0122
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0082
Nerves0.0000
Prostate0.0064
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 65
NORMAL
Bladder0.00000.00510.0000undef
Breast0.00530.01740.30583.2702
Ovary0.00610.00262.33720.4279
Endocrine tissue0.00730.00272.67910.3733
Gastrointestinal0.00970.00482.03570.4912
Brain0.00590.00551.08370.9227
Hematopoietic0.00420.0000undef0.0000
Skin0.00500.0000undef0.0000
Hepatic0.00000.0000undefundef
Heart0.00530.0000undef0.0000
Testicles0.00000.0000undefundef
Lungs0.00870.00711.22900.8137
Stomach-esophagus0.00000.01530.0000undef
Muscle-skeleton0.01030.0000undef0.0000
Kidneys0.00000.00680.0000undef
Pancreas0.00380.00550.68571.4584
Penis0.01200.02670.44922.2260
Prostate0.00000.00210.0000undef
Uterus0.00990.01420.69631.4363
Breast hyperplasia0.0000
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0087
FETUS
Development0.0000
Gastrointestinal0.0154
Brain0.0000
Hematopoietic0.0039
Heart-blood vessels0.0041
Lungs0.0000
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0136
Ovary-uterus0.0046
Endocrine tissue0.0000
Fetal0.0082
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0032
Testicles0.0156
Lungs0.0082
Nerves0.0040
Prostate0.0128
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 66
NORMAL
Bladder0.00930.15080.061616.2223
Breast0.00130.03920.034029.4320
Ovary0.01520.0000undef0.0000
Endocrine tissue0.00180.00270.66981.4930
Gastrointestinal0.01740.00483.66420.2729
Brain0.00510.00550.92891.0765
Hematopoietic0.09930.0000undef0.0000
Skin0.02490.0000undef0.0000
Hepatic0.00000.01290.0000undef
Heart0.00530.0000undef0.0000
Testicles0.00610.0000undef0.0000
Lungs0.02610.03070.85081.1753
Stomach-esophagus0.10620.02304.61970.2165
Muscle-skeleton0.01710.01800.95171.0508
Kidneys0.00000.00680.0000undef
Pancreas0.01140.0000undef0.0000
Penis0.12580.16000.78621.2720
Prostate0.00000.0000undefundef
Uterus0.08260.0000undef0.0000
Breast hyperplasia0.0036
Small intestine0.0000
Prostatic hyperplasia0.0000
Seminal vesicles0.0178
Sensory organs0.0000
White blood cells0.1018
FETUS
Development0.0000
Gastrointestinal0.0062
Brain0.0000
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0037
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0052
Gastrointestinal0.0122
Hematopoietic0.0057
Skin-muscle0.0000
Testicles0.0000
Lungs0.0410
Nerves0.0000
Prostate0.0449
Sensory organs0.0000
Electronic Northern for SEQ. ID NO.: 67
NORMAL
Bladder0.00930.00511.81850.5499
Breast0.00130.00440.30583.2702
Ovary0.00000.00520.0000undef
Endocrine tissue0.00730.01090.66981.4930
Gastrointestinal0.00000.0000undefundef
Brain0.00680.00551.23860.8074
Hematopoietic0.00280.0000undef0.0000
Skin0.00000.0000undefundef
Hepatic0.00000.01290.0000undef
Heart0.00420.0000undef0.0000
Testicles0.00000.02340.0000undef
Lungs0.00250.0000undef0.0000
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00000.0000undefundef
Kidneys0.00000.00680.0000undef
Pancreas0.00570.0000undef0.0000
Penis0.00300.0000undef0.0000
Prostate0.07860.05541.41980.7043
Uterus0.00330.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0000
Prostatic hyperplasia0.1011
Seminal vesicles0.0000
Sensory organs0.0000
White blood cells0.0017
FETUS
Development0.0000
Gastrointestinal0.0062
Brain0.0000
Hematopoietic0.0039
Heart-blood vessels0.0000
Lungs0.0037
Kidneys0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0082
Gastrointestinal0.0000
Hematopoietic0.0057
Skin-muscle0.0065
Testicles0.0078
Lungs0.0082
Nerves0.0030
Prostate0.0128
Sensory organs0.0000
Electronic Northern for Seq. ID: 149
NORMAL
B lymphoma0.00500.01360.36792.7181
Bladder0.00780.02580.30173.3143
Breast0.01140.02250.50881.9654
Large intestine0.01150.00851.34560.7432
Small intestine0.01920.01071.80360.5545
Ovary0.00890.00950.93331.0715
Endocrine tissue0.02090.03370.61951.6143
Brain0.02030.01701.19470.8371
Skin0.03670.0000undef0.0000
Hepatic0.01860.02540.73241.3653
Heart0.01830.01371.32910.7524
Testicles0.02410.0000undef0.0000
Lung0.01460.01660.87701.1402
Stomach-esophagus0.02900.01282.26710.4411
Muscle-skeleton0.00690.00740.92781.0778
Kidney0.01570.00483.24970.3077
Pancreas0.00500.02210.22444.4570
Prostate0.02170.01691.28010.7812
T lymphoma0.00760.0000undef0.0000
Uterus0.01630.02300.70681.4148
White blood cells0.02670.0000undef0.0000
Hematopoietic0.0080
Penis0.0161
Seminal vesicle0.0281
Sensory organs0.0118
FETUS
Development0.0000
Gastrointestinal0.0111
Brain0.0063
Hematopoietic0.0000
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0107
Lung0.0108
Adrenal gland0.0000
Kidney0.0124
Placenta0.0303
Prostate0.0499
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0253
Endocrine tissue0.0000
Fetal0.0070
Gastrointestinal0.0366
Hematopoietic0.0000
Skin-muscle0.0227
Testicles_n0.0042
Testicles_t0.0000
Lungs_n0.0000
Lungs_t0.0000
Nerves0.0090
Kidney_t0.0000
Ovary_uterus0.0203
Prostate_n0.0121
Sensory organs0.0000
White blood cells0.0000
Electronic Northern for Seq. ID: 150
NORMAL
B lymphoma0.00500.0000undef0.0000
Bladder0.00780.01170.66381.5065
Breast0.00880.01550.56931.7566
Large intestine0.02110.00287.40060.1351
Small intestine0.00270.0000undef0.0000
Ovary0.01190.00244.97730.2009
Endocrine tissue0.00320.01420.22634.4181
Brain0.00350.0000undef0.0000
Skin0.02570.0000undef0.0000
Hepatic0.02790.0000undef0.0000
Heart0.00710.01370.51691.9347
Testicles0.00400.0000undef0.0000
Lung0.02920.01481.97330.5068
Stomach-esophagus0.00000.00640.0000undef
Muscle-skeleton0.00170.0000undef0.0000
Kidney0.02690.0000undef0.0000
Pancreas0.01650.0000undef0.0000
Prostate0.01410.00522.71320.3686
T lymphoma0.00000.0000undefundef
Uterus0.00440.0000undef0.0000
White blood cells0.00000.0000undefundef
Hematopoietic0.0040
Penis0.0000
Seminal vesicle0.0070
Sensory organs0.0000
FETUS
Development0.0000
Gastrointestinal0.0056
Brain0.0000
Hematopoietic0.0039
Skin0.0000
Hepatic0.0000
Heart-blood vessel0.0036
Lung0.0145
Adrenal gland0.0254
Kidney0.0000
Placenta0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0000
Endocrine tissue0.0000
Fetal0.0058
Gastrointestinal0.0244
Hematopoietic0.0000
Skin-muscle0.0130
Testicles_n0.0000
Testicles_t0.0000
Lungs_n0.0293
Lungs_t0.0000
Nerves0.0020
Kidney_t0.0000
Ovary_uterus0.0068
Prostate_n0.0243
Sensory organs0.0000
White blood cells0.0000
Electronic Northern for Seq. ID: 151
NORMAL
B lymphoma0.00500.0000undef0.0000
Bladder0.00000.00700.0000undef
Breast0.00700.00980.71571.3973
Large intestine0.00380.00281.34560.7432
Small intestine0.00820.01070.77301.2937
Ovary0.00300.01190.24894.0182
Endocrine tissue0.00480.00710.67901.4727
Brain0.01040.01200.87041.1489
Skin0.00370.0000undef0.0000
Hepatic0.00460.00630.73241.3653
Heart0.00100.01370.073813.5431
Testicles0.00000.01180.0000undef
Lung0.00100.00550.17545.7011
Stomach-esophagus0.00000.00640.0000undef
Muscle-skeleton0.00860.01480.57991.7246
Kidney0.01120.01930.58031.7232
Pancreas0.00170.00550.29923.3427
Prostate0.00570.01170.48232.0732
T lymphoma0.00000.01490.0000undef
Uterus0.00150.00920.16066.2251
White blood cells0.00270.0000undef0.0000
Hematopoietic0.0080
Penis0.0027
Seminal vesicle0.0070
Sensory organs0.0235
FETUS
Development0.0000
Gastrointestinal0.0028
Brain0.0000
Hematopoietic0.0039
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0000
Lung0.0145
Adrenal gland0.0000
Kidney0.0000
Placenta0.0061
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0101
Endocrine tissue0.0000
Fetal0.0006
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0000
Testicles_n0.0125
Testicles_t0.0000
Lungs_n0.0195
Lungs_t0.0000
Nerves0.0100
Kidney_t0.0000
Ovary_uterus0.0068
Prostate_n0.0121
Sensory organs0.0000
White blood cells0.0000
Electronic Northern for Seq. ID: 152
NORMAL
B lymphoma0.02500.01361.83950.5436
Bladder0.00780.00701.10630.9039
Breast0.00970.02110.45922.1776
Large intestine0.01920.00573.36390.2973
Small intestine0.00550.02130.25773.8812
Ovary0.01780.01431.24430.8036
Endocrine tissue0.00480.01770.27163.6818
Brain0.01910.02690.70921.4100
Skin0.00730.0000undef0.0000
Hepatic0.00460.00630.73241.3653
Heart0.02330.02750.84911.1777
Testicles0.01610.0000undef0.0000
Lung0.01560.01291.20280.8314
Stomach-esophagus0.00000.01920.0000undef
Muscle-skeleton0.00860.00741.15970.8623
Kidney0.00900.00960.92851.0770
Pancreas0.00830.03870.21374.6798
Prostate0.00570.00910.62021.6125
T lymphoma0.00760.0000undef0.0000
Uterus0.00440.0000undef0.0000
White blood cells0.02460.0000undef0.0000
Hematopoietic0.0094
Penis0.0107
Seminal vesicle0.0000
Sensory organs0.0118
FETUS
Development0.1253
Gastrointestinal0.0305
Brain0.0938
Hematopoietic0.0275
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0142
Lung0.0325
Adrenal gland0.0254
Kidney0.0185
Placenta0.0242
Prostate0.0249
Sensory organs0.1255
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0816
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0354
Endocrine tissue0.0000
Fetal0.0741
Gastrointestinal0.0366
Hematopoietic0.0000
Skin-muscle0.1458
Testicles_n0.0000
Testicles_t0.0000
Lungs_n0.0098
Lungs_t0.0000
Nerves0.0191
Kidney_t0.0000
Ovary_uterus0.0248
Prostate_n0.0000
Sensory organs0.0155
White blood cells0.0000
Electronic Northern for Seq. ID: 153
NORMAL
B lymphoma0.00000.0000undefundef
Bladder0.00000.0000undefundef
Breast0.00260.01410.18795.3230
Large intestine0.00000.00570.0000undef
Small intestine0.00000.0000undefundef
Ovary0.00000.00480.0000undef
Endocrine tissue0.00000.0000undefundef
Brain0.00000.00100.0000undef
Skin0.00000.0000undefundef
Hepatic0.00000.00630.0000undef
Heart0.00100.0000undef0.0000
Testicles0.00000.0000undefundef
Lung0.00390.00182.10490.4751
Stomach-esophagus0.01450.0000undef0.0000
Muscle-skeleton0.00000.0000undefundef
Kidney0.00220.0000undef0.0000
Pancreas0.00000.0000undefundef
Prostate0.00090.00130.72351.3821
T lymphoma0.00250.0000undef0.0000
Uterus0.00150.0000undef0.0000
White blood cells0.00000.0000undefundef
Hematopoietic0.0000
Penis0.0054
Seminal vesicle0.0000
Sensory organs0.0000
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0039
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0071
Lung0.0036
Adrenal gland0.0000
Kidney0.0000
Placenta0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0051
Endocrine tissue0.0000
Fetal0.0000
Gastrointestinal0.0000
Hematopoietic0.0257
Skin-muscle0.0000
Testicles_n0.0000
Testicles_t0.0000
Lungs_n0.0000
Lungs_t0.0000
Nerves0.0010
Kidney_t0.0000
Ovary_uterus0.0023
Prostate_n0.0000
Sensory organs0.0000
White blood cells0.0000
Electronic Northern for Seq. ID: 154
NORMAL
B lymphoma0.00000.0000undefundef
Bladder0.01560.0000undef0.0000
Breast0.00790.01120.70451.4195
Large intestine0.00380.0000undef0.0000
Small intestine0.00270.0000undef0.0000
Ovary0.01190.0000undef0.0000
Endocrine tissue0.00160.0000undef0.0000
Brain0.00290.00600.48352.0680
Skin0.01470.0000undef0.0000
Hepatic0.00930.0000undef0.0000
Heart0.01120.0000undef0.0000
Testicles0.00000.0000undefundef
Lung0.00970.00741.31550.7601
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00510.00371.39170.7186
Kidney0.01120.00482.32120.4308
Pancreas0.01160.0000undef0.0000
Prostate0.00570.0000undef0.0000
T lymphoma0.00250.00750.33812.9576
Uterus0.00440.00460.96381.0375
White blood cells0.00480.03040.15786.3369
Hematopoietic0.0027
Penis0.0080
Seminal vesicle0.0070
Sensory organs0.0235
FETUS
Development0.0000
Gastrointestinal0.0083
Brain0.0000
Hematopoietic0.0000
Skin0.0000
Hepatic0.0260
Heart-blood vessels0.0036
Lung0.0217
Adrenal gland0.0000
Kidney0.0000
Placenta0.0000
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0000
Endocrine tissue0.0000
Fetal0.0185
Gastrointestinal0.0122
Hematopoietic0.0000
Skin-muscle0.0000
Testicles_n0.0042
Testicles_t0.0000
Lungs_n0.0000
Lungs_t0.0000
Nerves0.0050
Kidney_t0.0000
Ovary_uterus0.0000
Prostate_n0.0000
Sensory organs0.0000
White blood cells0.0000
Electronic Northern for Seq. ID: 155
NORMAL
B lmphoma0.00750.0000undef0.0000
Bladder0.01560.00473.31900.3013
Breast0.00350.01970.17895.5892
Large intestine0.00960.00851.12130.8918
Small intestine0.01100.0000undef0.0000
Ovary0.00590.00481.24430.8036
Endocrine tissue0.00800.01240.64671.5464
Brain0.00580.00105.80260.1723
Skin0.00370.0000undef0.0000
Hepatic0.00000.00630.0000undef
Heart0.01220.0000undef0.0000
Testicles0.02010.01181.69640.5895
Lung0.00100.00740.13167.6015
Stomach-esophagus0.02170.0000undef0.0000
Muscle-skeleton0.00510.00740.69581.4371
Kidney0.00000.0000undefundef
Pancreas0.01160.0000undef0.0000
Prostate0.00470.00650.72351.3821
T lymphoma0.01010.00751.35250.7394
Uterus0.00440.00460.96381.0375
White blood cells0.00480.03040.15786.3369
Hematopoietic0.0040
Penis0.0134
Seminal vesicle0.0000
Sensory organs0.0000
FETUS
Development0.0278
Gastrointestinal0.0056
Brain0.0063
Hematopoietic0.0118
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0142
Lung0.0108
Adrenal gland0.0254
Kidney0.0124
Placenta0.0061
Prostate0.0499
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0101
Endocrine tissue0.0000
Fetal0.0185
Gastrointestinal0.0122
Hematopoietic0.0000
Skin-muscle0.0194
Testicles_n0.0125
Testicles_t0.0000
Lungs_n0.0000
Lungs_t0.0000
Nerves0.0141
Kidney_t0.0000
Ovary_uterus0.0135
Prostate_n0.0121
Sensory organs0.0077
White blood cells0.0000
Electronic Northern for Seq. ID: 156
NORMAL
B lymphoma0.00750.0000undef0.0000
Bladder0.00000.01880.0000undef
Breast0.00260.00560.46972.1292
Large intestine0.00380.0000undef0.0000
Small intestine0.00550.0000undef0.0000
Ovary0.00590.00481.24430.8036
Endocrine tissue0.00320.0000undef0.0000
Brain0.00170.00300.58031.7234
Skin0.00000.0000undefundef
Hepatic0.00460.0000undef0.0000
Heart0.00510.01370.36922.7086
Testicles0.00400.0000undef0.0000
Lung0.00490.01290.37592.6605
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00170.00370.46392.1557
Kidney0.00000.0000undefundef
Pancreas0.00170.01100.14966.6855
Prostate0.00000.00130.0000undef
T lymphoma0.00510.0000undef0.0000
Uterus0.01480.00463.21280.3113
White blood cells0.00070.0000undef0.0000
Hematopoietic0.0053
Penis0.0027
Seminal vesicle0.0000
Sensory organs0.0353
FETUS
Development0.0000
Gastrointestinal0.0000
Brain0.0000
Hematopoietic0.0118
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0000
Lung0.0072
Adrenal gland0.0000
Kidney0.0124
Placenta0.0242
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0000
Endocrine tissue0.0245
Fetal0.0151
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0259
Testicles_n0.0000
Testicles_t0.0000
Lungs_n0.0195
Lungs_t0.0000
Nerves0.0090
Kidney_t0.0000
Ovary_uterus0.0135
Prostate_n0.0000
Sensory organs0.0000
White blood cells0.0000
Electronic Northern for Seq. ID: 157
NORMAL
B lymphoma0.01000.01360.73581.3590
Bladder0.00000.00700.0000undef
Breast0.01060.01410.75151.3308
Large intestine0.00570.01140.50461.9818
Small intestine0.00270.0000undef0.0000
Ovary0.02080.02150.96781.0333
Endocrine tissue0.01930.04080.47242.1170
Brain0.00870.01100.79131.2638
Skin0.00370.0000undef0.0000
Hepatic0.00000.01900.0000undef
Heart0.01010.0000undef0.0000
Testicles0.03610.01183.05350.3275
Lung0.01170.01850.63151.5836
Stomach-esophagus0.00720.0000undef0.0000
Muscle-skeleton0.00170.03690.046421.5570
Kidney0.02010.03370.59691.6754
Pancreas0.01490.0000undef0.0000
Prostate0.01320.02470.53311.8758
T lymphoma0.01770.02990.59171.6900
Uterus0.00590.00461.28510.7781
White blood cells0.02190.0000undef0.0000
Hematopoietic0.0094
Penis0.0161
Seminal vesicle0.0070
Sensory organs0.0353
FETUS
Development0.0139
Gastrointestinal0.0167
Brain0.0000
Hematopoietic0.0039
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0142
Lung0.0036
Adrenal gland0.0254
Kidney0.0185
Placenta0.0061
Prostate0.0249
Sensory organs0.0126
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0203
Endocrine tissue0.0000
Fetal0.0209
Gastrointestinal0.0366
Hematopoietic0.0000
Skin-muscle0.0972
Testicles_n0.0251
Testicles_t0.0000
Lungs_n0.0098
Lungs_t0.0000
Nerves0.0151
Kidney_t0.0000
Ovary_uterus0.0450
Prostate_n0.0303
Sensory organs0.0310
White blood cells0.0000
Electronic Northern for Seq. ID: 158
NORMAL
B lymphoma0.00750.0000undef0.0000
Bladder0.01560.00702.21270.4519
Breast0.00880.01550.56931.7566
Large intestine0.00770.00571.34560.7432
Small intestine0.00820.0000undef0.0000
Ovary0.00000.00240.0000undef
Endocrine tissue0.00160.0000undef0.0000
Brain0.00410.02090.19345.1701
Skin0.01470.0000undef0.0000
Hepatic0.00000.01900.0000undef
Heart0.00410.0000undef0.0000
Testicles0.01200.01181.01780.9825
Lung0.01460.00552.63110.3801
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00510.01480.34792.8743
Kidney0.00450.00960.46422.1540
Pancreas0.00170.00550.29923.3427
Prostate0.00470.00650.72351.3821
T lymphoma0.00510.0000undef0.0000
Uterus0.01630.02760.58901.6977
White blood cells0.00000.0000undefundef
Hematopoietic0.0053
Penis0.0107
Seminal vesicle0.0000
Sensory organs0.0118
FETUS
Development0.0000
Gastrointestinal0.0028
Brain0.0063
Hematopoietic0.0118
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0036
Lung0.0000
Adrenal gland0.0000
Kidney0.0124
Placenta0.0061
Prostate0.0499
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0000
Endocrine tissue0.0000
Fetal0.0041
Gastrointestinal0.0000
Hematopoietic0.0257
Skin-muscle0.0194
Testicles_n0.0000
Testicles_t0.0000
Lungs_n0.0098
Lungs_t0.0000
Nerves0.0060
Kidney_t0.0000
Ovary_uterus0.0068
Prostate_n0.0000
Sensory organs0.0000
White blood cells0.0000
Electronic Northern for Seq. ID: 159
NORMAL
B lymphoma0.00500.04070.12268.1542
Bladder0.00000.00470.0000undef
Breast0.00970.00980.98401.0162
Large intestine0.00770.01710.44852.2295
Small intestine0.00550.01070.51531.9406
Ovary0.00890.00721.24430.8036
Endocrine tissue0.00640.01060.60361.6568
Brain0.00750.00900.83821.1931
Skin0.00000.0000undefundef
Hepatic0.00930.0000undef0.0000
Heart0.00000.0000undefundef
Testicles0.00800.00591.35710.7369
Lung0.00680.00551.22780.8144
Stomach-esophagus0.00000.00640.0000undef
Muscle-skeleton0.00340.0000undef0.0000
Kidney0.00450.00960.46422.1540
Pancreas0.00170.0000undef0.0000
Prostate0.00660.00135.06460.1974
T lymphoma0.01010.00751.35250.7394
Uterus0.00440.02300.19285.1876
White blood cells0.00410.0000undef0.0000
Hematopoietic0.0147
Penis0.0027
Seminal vesicle0.0000
Sensory organs0.0000
FETUS
Development0.0000
Gastrointestinal0.0028
Brain0.0063
Hematopoietic0.0079
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0036
Lung0.0072
Adrenal gland0.0254
Kidney0.0247
Placenta0.0121
Prostate0.0000
Sensory organs0.0126
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0203
Endocrine tissue0.0000
Fetal0.0087
Gastrointestinal0.0244
Hematopoietic0.0257
Skin-muscle0.0097
Testicles_n0.0209
Testicles_t0.0000
Lungs_n0.0000
Lungs_t0.0000
Nerves0.0030
Kidney_t0.0000
Ovary_uterus0.0090
Prostate_n0.0000
Sensory organs0.0774
White blood cells0.0000
Electronic Northern for Seq. ID: 160
NORMAL
B lymphoma0.00000.0000undefundef
Bladder0.00780.00233.31900.3013
Breast0.00090.00840.10449.5814
Large intestine0.00570.0000undef0.0000
Small intestine0.00270.01070.25773.8812
Ovary0.00300.00480.62221.6073
Endocrine tissue0.00160.00180.90541.1045
Brain0.00410.00401.01550.9848
Skin0.00000.0000undefundef
Hepatic0.01860.0000undef0.0000
Heart0.00100.0000undef0.0000
Testicles0.00000.0000undefundef
Lung0.00190.0000undef0.0000
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00170.00370.46392.1557
Kidney0.00450.0000undef0.0000
Pancreas0.00170.00550.29923.3427
Prostate0.00090.0000undef0.0000
T lymphoma0.00760.00751.01430.9859
Uterus0.00300.0000undef0.0000
White blood cells0.00410.0000undef0.0000
Hematopoietic0.0040
Penis0.0080
Seminal vesicle0.0070
Sensory organs0.0000
FETUS
Development0.0000
Gastrointestinal0.0111
Brain0.0125
Hematopoietic0.0039
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0071
Lung0.0000
Adrenal gland0.0000
Kidney0.0062
Placenta0.0121
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0101
Endocrine tissue0.0490
Fetal0.0058
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0065
Testicles_n0.0000
Testicles_t0.0000
Lungs_n0.0000
Lungs_t0.0000
Nerves0.0020
Kidney_t0.0000
Ovary_uterus0.0045
Prostate_n0.0000
Sensory organs0.0000
White blood cells0.0000
Electronic Northern for Seq. ID: 161
NORMAL
B lymphoma0.00500.0000undef0.0000
Bladder0.00780.00471.65950.6026
Breast0.00090.00840.10449.5814
Large intestine0.00000.0000undefundef
Small intestine0.00000.01070.0000undef
Ovary0.00000.00480.0000undef
Endocrine tissue0.00640.01060.60361.6568
Brain0.00580.00501.16050.8617
Skin0.00000.0000undefundef
Hepatic0.00000.01900.0000undef
Heart0.00410.0000undef0.0000
Testicles0.00400.01180.33932.9475
Lung0.00390.00182.10490.4751
Stomach-esophagus0.00000.0000undefundef
Muscle-skeleton0.00000.0000undefundef
Kidney0.00220.00480.46422.1540
Pancreas0.00500.00550.89751.1142
Prostate0.08480.06511.30230.7679
T lymphoma0.00760.00751.01430.9859
Uterus0.00590.00461.28510.7781
White blood cells0.00410.0000undef0.0000
Hematopoietic0.0027
Penis0.0027
Seminal vesicle0.0000
Sensory organs0.0000
FETUS
Development0.0000
Gastrointestinal0.0056
Brain0.0000
Hematopoietic0.0039
Skin0.0000
Hepatic0.0000
Heart-blood vessels0.0000
Lung0.0036
Adrenal gland0.0507
Kidney0.0000
Placenta0.0121
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Breast_t0.0000
Large intestine_t0.0000
Ovary_n0.0000
Ovary_t0.0000
Endocrine tissue0.0000
Fetal0.0104
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0097
Testicles_n0.0084
Testicles_t0.0000
Lungs_n0.0000
Lungs_t0.0000
Nerves0.0050
Kidney_t0.0000
Ovary_uterus0.0000
Prostate_n0.0546
Sensory organs0.0000
White blood cells0.0000
Electronic Northern for SEQ. ID NO.: 201
NORMAL
Bladder0.00000.00770.0000undef
Breast0.00270.03050.087411.4458
Ovary0.00300.08330.036527.3828
Endocrine tissue0.00180.01090.16745.9721
Gastrointestinal0.00000.00480.0000undef
Brain0.05760.05481.05280.9499
Hematopoietic0.00420.0000undef0.0000
Skin0.00990.16930.058717.0262
Hepatic0.04460.18120.24594.0660
Heart0.01380.01371.00200.9980
Testicles0.00000.10520.0000undef
Lungs0.00870.08510.10249.7640
Stomach-esophagus0.00000.02300.0000undef
Muscle-skeleton0.02740.28200.097210.2887
Kidneys0.34480.42450.81231.2311
Pancreas0.12680.03873.28140.3047
Penis0.00300.0000undef0.0000
Prostate0.00000.00210.0000undef
Uterus0.00330.04270.077412.9263
Breast hyperplasia0.0073
Small intestine0.0000
Prostatic hyperplasia0.0059
Seminal vesicles0.0000
Sensory organs0.0118
White blood cells0.1958
FETUS
Development0.0922
Gastrointestinal0.0247
Brain0.0000
Hematopoietic0.0079
Heart-blood vessels0.0123
Lungs0.0037
Kidneys0.0062
Prostate0.0000
Sensory organs0.1815
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0000
Endocrine tissue0.0000
Fetal0.0134
Gastrointestinal0.0000
Hematopoietic0.0000
Skin-muscle0.0032
Testicles0.0000
Lungs0.0164
Nerves0.0231
Prostate0.0064
Sensory organs0.0310
Electronic Northern for SEQ. ID NO.: 202
NORMAL
Bladder0.00000.07920.0000undef
Breast0.00400.02610.15296.5404
Ovary0.00910.01560.58431.7114
Endocrine tissue0.00360.00271.33960.7465
Gastrointestinal0.01740.01431.22140.8187
Brain0.00000.00440.0000undef
Hematopoietic0.00560.0000undef0.0000
Skin0.01990.0000undef0.0000
Hepatic0.01990.06470.30613.2673
Heart0.00110.0000undef0.0000
Testicles0.00610.0000undef0.0000
Lungs0.02240.01181.89620.5274
Stomach-esophagus0.01930.0000undef0.0000
Muscle-skeleton0.00340.0000undef0.0000
Kidneys0.01780.00682.60500.3839
Pancreas0.00190.03310.057117.5010
Penis0.00600.08000.074913.3560
Prostate0.00950.00641.49150.6705
Uterus0.00170.0000undef0.0000
Breast hyperplasia0.0000
Small intestine0.0031
Prostatic hyperplasia0.0119
Seminal vesicles0.0000
Sensory organs0.0235
White blood cells0.0000
FETUS
Development0.0000
Gastrointestinal0.0092
Brain0.0063
Hematopoietic0.0000
Heart-blood vessels0.0000
Lungs0.0259
Kidneys0.0062
Prostate0.0000
Sensory organs0.0000
STANDARDIZED/
SUBTRACTED
LIBRARIES
Breast0.0000
Ovary-uterus0.0068
Endocrine tissue0.0000
Fetal0.0274
Gastrointestinal0.0122
Hematopoietic0.0000
Skin-muscle0.0000
Testicles0.0000
Lungs0.0410
Nerves0.0000
Prostate0.0064
Sensory organs0.0000
|
[0087] 2.2. Fisher Test
[0088] In order to decide whether a partial sequence S of a gene occurs significantly more often or less often in a library for normal tissue than in a library for degenerated tissue, Fisher's exact test, a standard statistical process, is carried out (Hays, W. L., (1991) Statistics, Harcourt Brace College Publishers, Fort Worth).
[0089] The null hypothesis reads: The two libraries cannot be distinguished with respect to the frequency of sequences homologous to S. If the null hypothesis can be rejected with high enough certainty, the gene belonging to S is accepted as an advantageous candidate for a cancer gene, and in the next step an attempt is made to achieve lengthening of its sequence.
EXAMPLE 3
[0090] Automatic Lengthening of the Partial Sequence
[0091] Automatic lengthening of partial sequence S is completed in three steps:
[0092] 1. Determination of all sequences homologous to S from the total set of available sequences using BLAST.
[0093] 2. Assembling these sequences by means of the standard program GAP4 (Bonfield, J. K.; Smith, K. F. and Staden, R. (1995), Nucleic Acids Research 23 4992-4999) (contig formation).
[0094] 3. Computation of a consensus sequence C from the assembled sequences.
[0095] The consensus sequence C will generally be longer than initial sequence S. Its electronic Northern Blot will accordingly deviate from that for S. A repeated Fisher test decides whether the alternative hypothesis of deviation from a uniform expression in the two libraries can be maintained. If this is the case, an attempt is made to lengthen C in the same way as S. This iteration is continued with consensus sequences Ci (i: iteration index) obtained in each case until the alternative hypothesis is rejected (if H0 Exit; truncation criterion I) or until automatic lengthening is no longer possible (while Ci>Ci−1; truncation criterion II).
[0096] In the case of truncation criterion II, with the consensus sequence present after the last iteration, a complete or roughly complete sequence of a gene which can be related to cancer with high statistical certainty is acquired.
[0097] Analogously to the above-described examples, it was possible to find the nucleic acid sequences described in Table I from breast tumor tissue.
[0098] Furthermore, for the individual nucleic acid sequences, it was possible to determine the peptide sequences (ORFs) that are listed in Table II, in which no peptide can be assigned to a few nucleic acid sequences and more than one peptide can be assigned to some nucleic acid sequences. As already mentioned above, both the determined nucleic acid sequences and the peptide sequences assigned to the nucleic acid sequences are the subject of this invention.
EXAMPLE 4
[0099] Mapping of Nucleic Acid Sequences on the Human Genome
[0100] Human genes were mapped using the Stanford G3 Hybrid Panel (Stewart et al., 1997), which is marketed by Research Genetics, Huntsville, Ala. This panel consists of 83 different genomic DNAs of human-hamster hybrid cell lines and allows resolution of 500 kilobases. The hybrid cell lines were obtained by fusion of irradiated diploid human cells with cells of the Chinese hamster. The retention pattern of the human chromosome fragments is determined by means of gene-specific primers in a polymerase chain reaction and is analyzed using software available from the Stanford RH server (http://www.stanford.edu/RH/rhserver_form2. html). This program determines the STS marker that is nearest to the desired gene. The corresponding cytogenetic band was determined using the “Mapview” program of the Genome Database (GDB), (http://gdbwww.dkfz-heidelberg.de).
[0101] In addition to mapping of genes on the human chromosome set by various experimental methods, it is possible to determine the location of genes on this by biocomputer methods. To do this, the known program e-PCR was used (Schuler G D (1998) Electronic PCR: Bridging the gap between genome mapping and genome sequencing. Trends Biotechnol 16: 456-459, Schuler G D (1997). Sequence mapping by electronic PCR. Genome Res. 7: 541-550). The database used here no longer corresponds to the one cited in the literature, but is a further development which includes data from the public database RHdb (http://www.ebi.ac.uk/RHdb/-index.html). Analogously to the mapping by the hybrid panels, the results were evaluated with the above-mentioned software and the software of the Whitehead Institute (http://carbon.wi.mit.edu:8000/cgi-bin/contig/rhmapper.pl).
EXAMPLE 5
[0102] Obtaining Genomic DNA Sequences (BAC Clones)
[0103] The genomic sequences that correspond to the differential cDNAs were isolated from commercial BAC libraries. BAC libraries of the Genome Systems Company, St. Louis, Mo., which were produced from human lymphocytes, were used (http://www.genomesystems.com) and those of the Research Genetics Company, which were described as follows, were used: Shizuya, H.; B. Birren, U-J. Kim, V. Mancino, T. Slepak, Y. Tachiiri, M. Simon (1992) Proc. Natl. Acad. Sci., USA 89: 8794-8797; http://www.tree.caltech.edu/. From these libraries, the BAC clones with the procedure of “down-to-the-well” were isolated. In this procedure, a library consisting of BAC clones (the library covers roughly 3× the human genome) is combined in various groups. This takes place in such a way that after the execution of a gene-specific PCR in the various pools, a definite clone assignment is possible. This address together with the name of the library which is being used unequivocally fixes the clones and thus the DNA sequence of these clones.
[0104] The following examples explain the successful isolation of the genomic BAC clones without limiting them thereto.
[0105] The libraries of genome systems used were CITB B and CITB C. Clones from the library of genome systems are underlined. Breast Tumor
5|
|
Seq. ID
No.Identified BACs
|
|
3431/F/22461/J/18276/D/4360/G/5276/D/5
7241/D/11
913/M/23102/H/20210/0/17278/B/10278/B/20
10319/P/11492/J/15
23565/E/8
2538/D/460/B/1770/K/14
39425/C/18
42221/L/9407/M/9
43233/F/11411/C/6411/C/8461/C/20
45557/D/15
58222/C/8431/0/16
|
[0106]
6
TABLE I
|
|
|
Col. 1
Seq ID No.
|
Col. 2
Expression
|
Col. 3
Function
|
Col. 4
Modules
|
Col. 5
Length of the applied sequence (bp)
|
Col. 6
Chromosomal localization
|
Col. 7
Marker
|
|
Seq
|
ID No.
Expression
Function
|
|
2
Overexpressed in
A 17-kDA interferon-induced gene—
|
the breast tumor
nothing is published on its function
|
3
Overexpressed in
Presumably the human ortholog of the
|
the breast tumor
5E5-antigen of rats, in this connection
|
it is probably a transcription factor.
|
4
Overexpressed in
The human “alpha-2-macroglobulin
|
the breast tumor
receptor-associated protein” belongs to
|
a “proteinase-scavenging system” that
|
recovers proteinase activity.
|
5
Overexpressed in
The human “macrophage migration
|
the breast tumor
inhibition factor related protein 14
|
(MRP-14)” probably plays a role in
|
immunomodulation.
|
6
Overexpressed in
The human lamin B2 (LAMB2) forms,
|
the breast tumor
i.a., the nuclear lamina, which lies
|
below the inside cell membrane of the
|
nucleus. It plays an important role in
|
the regulation of the nuclear structure
|
during the cell cycle and the
|
transcription.
|
7
Overexpressed in
Presumably the regulatory subunit of
|
the breast tumor
an RNA-binding protein,; nothing was
|
published on its function.
|
8
Overexpressed in
The human antioxidant enzyme AOE37-
|
the breast tumor
2, which presumably represents a
|
peroxidase (peroxiredoxin family).
|
The latter protect the cells from
|
oxidative processes.
|
9
Overexpressed in
Unknown
|
the breast tumor
|
11
Overexpressed in
The human “macrophage capping
|
the breast tumor
protein,” recently named “CapG,”
|
regulates the cell mobility via the actins.
|
12
Overexpressed in
An estrogen-inducible gene (LIV-1),
|
the breast tumor
whose function is not yet understood.
|
13
Overexpressed in
The human “integrin-linked kinase
|
the breast tumor
(ILK)” controls the assembly of the
|
fibrinectin matrix and inhibits the
|
synthesis of E-cadherin. ILK-
|
coverexpressing cells produce tumors
|
in nude mice.
|
14
Overexpressed in
Unknown, human HISTONE H2B2
|
the breast tumor
|
15
Overexpressed in
Presumably the human ortholog of
|
the breast tumor
the enhancer of the Drosophila
|
“rudimentary” gene (“human enhancer
|
of rudimentary homolog”); it possibly
|
plays a role in the pyrimidine
|
metabolism.
|
16
Overexpressed in
The human Tim23 is localized in the
|
the breast tumor
protein translocase complex of the
|
inside mitochondrial membrane.
|
17
Overexpressed in
Presumably a new Ca2+-binding
|
the breast tumor
protein.
|
18
Overexpressed in
A new human gene with similarity to
|
the breast tumor
the mouse “synaptosomal associated
|
protein.”
|
19
Overexpressed in
The human ITF (“intestinal trefoil
|
the breast tumor
factor“).
|
20
Overexpressed in
The human RNA polymerase II
|
the breast tumor
transcription factor.
|
21
Overexpressed in
Unknown
|
the breast tumor
|
22
Overexpressed in
The human JAK1 tyrosine kinase.
|
the breast tumor
|
23
Overexpressed in
Unknown
|
the breast tumor
|
24
Overexpressed in
Unknown
|
the breast tumor
|
25
Overexpressed in
Unknown
|
the breast tumor
|
27
Overexpressed in
Unknown
|
the breast tumor
|
29
Overexpressed in
The human ribonuclease 6-precursor
|
the breast tumor
molecule.
|
30
Overexpressed in
The human 80K-L protein (also
|
the breast tumor
MARCKS), a substrate of the protein
|
kinase C. MARCKS binds calmodulin,
|
actin and synapsin.
|
31
Overexpressed in
The human BCL-X, an apoptosis
|
the breast tumor
regulator.
|
33
Overexpressed in
The human benzodiazepine receptor.
|
the breast tumor
|
35
Overexpressed in
The human ubiquinone oxidoreductase.
|
the breast tumor
|
36
Overexpressed in
A new ATPase, which belongs to the
|
the breast tumor
kinesin family.
|
37
Overexpressed in
The monocyte/macrophage “Ig-
|
the breast tumor
related receptor MIR-7.”
|
38
Overexpressed in
Unknown
|
the breast tumor
|
39
Overexpressed in
A new putative serine/threonine
|
the breast tumor
kinase.
|
40
Overexpressed in
The putative copper-receiving
|
the breast tumor
protein hCTR2.
|
41
Overexpressed in
The human alpha galactosidase A.
|
the breast tumor
|
42
Overexpressed in
Unknown
|
the breast tumor
|
43
Overexpressed in
This new sequence has a certain
|
the breast tumor
homology to the benzoate-coenzyme A
|
ligase.
|
44
Overexpressed in
7TM protein
|
the breast tumor
|
45
Overexpressed in
The human phosphatase 2A B56
|
the breast tumor
(PP2A).
|
46
Overexpressed in
HUMAN homolog to a mouse co-
|
the breast tumor
chaperonin; Hs. 24930; homo sapiens
|
cofactor A protein mRNA
|
47
Overexpressed in
Homolog to an imprinted gene of
|
the breast tumor
chromosome 11; Hs. 110222
|
48
Overexpressed in
Presumably the human ortholog of
|
the breast tumor
an ATP-dependent RNA-helicase.
|
49
Overexpressed in
Coupling factor F6 is a component of
|
the breast tumor
the mitochondrial ATP-synthase, which
|
is necessary for the interaction of
|
catalytic and proton-transferring
|
segments; Hs. 73851
|
50
Overexpressed in
Unknown
|
the breast tumor
|
51
Overexpressed in
New human ATPase
|
the breast tumor
|
52
Overexpressed in
Unknown; Hs. 10927
|
the breast tumor
|
53
Overexpressed in
Homolog to the NAG-2 gene; Hs.
|
the breast tumor
26518
|
54
Overexpressed in
Arginine methyltransferase; Hs.
|
the breast tumor
20521
|
55
Overexpressed in
Unknown; Hs. 5241
|
the breast tumor
|
56
Overexpressed in
Stromelysine
|
the breast tumor
|
57
Overexpressed in
Human GTP-binding protein
|
the breast tumor
|
58
Overexpressed in
Homolog to prostate-binding protein,
|
the breast tumor
subunit C-1
|
59
Overexpressed in
Unknown
|
the breast tumor
|
61
Overexpressed in
Glucose-6-phosphate dehydrogenase
|
the breast tumor
homolog
|
62
Overexpressed in
Unknown
|
the breast tumor
|
63
Overexpressed in
Unknown
|
the breast tumor
|
64
Overexpressed in
Ets transcription factor
|
the breast tumor
|
65
Overexpressed in
IL 13 receptor alpha-1 chain
|
the breast tumor
|
66
Overexpressed in
Inhibition of cell division and the
|
the breast tumor
macrophage activity. Protein-kinase
|
inhibitor
|
67
Overexpressed in
Possibly a dehydrogenase
|
the breast tumor
|
149
Overexpressed in
Lengthening to Seq. ID No. 4
|
the breast tumor
|
150
Overexpressed in
Lengthening to Seq. ID No. 9
|
the breast tumor
|
151
Overexpressed in
Lengthening to Seq. ID No. 25
|
the breast tumor
|
152
Overexpressed in
Lengthening to Seq. ID No. 27
|
the breast tumor
|
153
Overexpressed in
Lengthening to Seq. ID No. 44
|
the breast tumor
|
154
Overexpressed in
Lengthening to Seq. ID No. 45
|
the breast tumor
|
155
Overexpressed in
Lengthening to Seq. ID No. 48
|
the breast tumor
|
156
Overexpressed in
Lengthening to Seq. ID No. 50
|
the breast tumor
|
157
Overexpressed in
Lengthening to Seq. ID No. 51
|
the breast tumor
|
158
Overexpressed in
Lengthening to Seq. ID No. 53
|
the breast tumor
|
159
Overexpressed in
Lengthening to Seq. ID No. 62
|
the breast tumor
|
160
Overexpressed in
Lengthening to Seq. ID No. 63
|
the breast tumor
|
161
Overexpressed in
Lengthening to Seq. ID No. 67
|
the breast tumor
|
201
Overexpressed in
The human osteopontin.
|
the breast tumor
|
202
Overexpressed in
Proteoglycan
|
the breast tumor
|
|
[Key:]
|
unbekannt = unknown
|
[0107]
7
TABLE II
|
|
|
DNA Sequence
Peptide Sequence
|
Seq. ID. No.
(ORF's) Seq. ID. No.
|
|
|
3
71
|
9
72
73
74
75
76
|
14
77
|
16
78
|
17
79
|
18
81
|
19
82
|
20
83
|
21
84
85
86
87
|
23
88
89
|
24
90
|
25
91
|
27
92
93
|
29
94
|
31
95
96
97
98
|
33
99
100
|
35
101
|
36
102
|
38
103
|
39
104
|
40
105
|
41
106
|
42
107
|
43
108
109
110
|
44
111
112
113
|
46
114
|
47
115
116
|
48
117
|
49
118
119
|
50
120
|
51
121
|
52
123
|
53
126
|
54
128
|
55
129
130
131
132
133
|
56
134
135
|
57
136
|
58
137
|
59
138
139
|
61
140
|
62
141
|
63
142
143
144
|
64
145
|
66
146
|
67
147
|
149
162
163
164
|
150
165
166
167
|
151
168
|
152
172
|
153
174
|
154
177
178
179
|
155
180
|
156
183
184
185
|
157
187
|
158
190
|
159
192
193
194
|
160
195
196
197
|
161
198
|
|
[0108] The inventive nucleic acid sequences Seq. ID No. 2-67, 149-161, and 201-202 of the determined candidate genes and the determined amino acid sequences Seq. ID No. 71-148, and 162-200 are described in the following sequence protocol.
Claims
- 1. A nucleic acid sequence that codes a gene product or a part thereof, comprising
a) a nucleic acid sequence, selected from the group Seq. Id no. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 156-158, and 160-161 b) an allelic variation of the nucleic acid sequences named under a) or c) a nucleic acid sequence that is complementary to the nucleic acid sequences named under a) or b).
- 2. A nucleic acid sequence according to one of the sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 156-158, 160-161 or a complementary or allelic variant thereof.
- 3. Nucleic acid sequence Seq. ID No. 2-67, 149-161, 201-202, characterized in that it is expressed elevated in breast tumor tissue.
- 4. BAC, PAC and Cosmid clones containing functional genes and their chromosomal localization according to sequences Seq. ID No. 2-67, 149-161, and 201-202 for use as a vehicle for gene transfer.
- 5. A nucleic acid sequence according to claims 1 to 4, wherein it has 90% homology to a human nucleic acid sequence.
- 6. A nucleic acid sequence according to claims 1 to 4, wherein it has 95% homology to a human nucleic acid sequence.
- 7. A nucleic acid sequence comprising a portion of the nucleic acid sequences named in claims 1 to 6, in such a sufficient amount that they hybridize with the sequences according to claims 1 to 6.
- 8. A nucleic acid sequence according to claims 1 to 7, wherein the size of the fragment has a length of at least 50 to 4500 bp.
- 9. A nucleic acid sequence according to claims 1 to 7, wherein the size of the fragment has a length of at least 150 to 4000 bp.
- 10. A nucleic acid sequence according to one of claims 1 to 9, which codes at least one partial sequence of a bioactive polypeptide.
- 11. An expression cassette, comprising a nucleic acid fragment or a sequence according to one of claims 1 to 9, together with at least one control or regulatory sequence.
- 12. An expression cassette, comprising a nucleic acid fragment or a sequence according to claim 11, in which the control or regulatory sequence is a suitable promoter.
- 13. An expression cassette according to one of claims 11 and 12, wherein the DNA sequences located on the cassette code a fusion protein, which comprises a known protein and a bioactive polypeptide fragment.
- 14. Use of nucleic acid sequences according to claims 1 to 10 for producing full-length genes.
- 15. A DNA fragment, comprising a gene, that can be obtained from the use according to claim 14.
- 16. Host cell, containing as the heterologous part of its expressible genetic information a nucleic acid fragment according to one of claims 1 to 10.
- 17. Host cell according to claim 16, wherein it is a prokaryotic or eukaryotic cell system.
- 18. Host cell according to one of claims 16 or 17, wherein the prokaryotic cell system is E. coli and the eukaryotic cell system is an animal, human or yeast cell system.
- 19. A process for producing a polypeptide or a fragment, wherein the host cells according to claims 16 to 18 are cultivated.
- 20. An antibody that is directed against a polypeptide or a fragment that is coded by the nucleic acids of sequences Seq. ID No. 2-67, 149-161, and 201-202, which can be obtained according to claim 19.
- 21. An antibody according to claim 20, wherein it is monoclonal.
- 22. Polypeptide partial sequences according to sequences Seq. ID No. 71-148, and 162-198.
- 23. Polypeptide partial sequences according to claim 22, with at least 80% homology to these sequences.
- 24. Polypeptide partial sequences according to claim 22, with at least 90% homology to these sequences.
- 25. Use of polypeptide partial sequences according to sequences Seq. ID No. 71-148, and 162-198 as tools for finding active ingredients against breast cancer.
- 26. Use of nucleic acid sequences according to sequences Seq. ID No. 2-67, 149-161 and 201-202 for expression of polypeptides that can be used as tools for finding active ingredients against breast cancer.
- 27. Use of nucleic acid sequences Seq. ID No. 2-67, 149-161, and 201-202 in sense or antisense form.
- 28. Use of polypeptide partial sequences Seq. ID No. 71-148 and 162-198 as pharmaceutical agents in gene therapy for treatment of breast cancer.
- 29. Use of polypeptide partial sequences Seq. ID No. 71-148, and 162-198 for the production of a pharmaceutical agent for treatment of breast cancer.
- 30. Pharmaceutical agent, containing at least one polypeptide partial sequence Seq. ID No. 71-148, and 162-198.
- 31. A nucleic acid sequence according to claims 1 to 10, wherein it is a genomic sequence.
- 32. A nucleic acid sequence according to claims 1 to 10, wherein it is an mRNA sequence.
- 33. Genomic genes, their promoters, enhancers, silencers, exon structure, intron structure and their splice variants, that can be obtained from cDNAs of sequences Seq. ID No. 2-67, 149-161 and 201-202.
- 34. Use of the genomic genes according to claim 33, together with suitable regulatory elements.
- 35. Use according to claim 34, wherein the regulatory element is a suitable promoter and/or enhancer.
- 36. A nucleic acid sequence according to claims 1 to 7, wherein the size of the fragment has a length of at least 450 to 3500 bp.
Priority Claims (1)
Number |
Date |
Country |
Kind |
198 13 839.3 |
Mar 1998 |
DE |
|
Divisions (1)
|
Number |
Date |
Country |
Parent |
09646673 |
Sep 2000 |
US |
Child |
10131410 |
Apr 2002 |
US |