Human-nucleic acid sequences from breast tumor tissue

Information

  • Patent Application
  • 20030235915
  • Publication Number
    20030235915
  • Date Filed
    April 25, 2002
    22 years ago
  • Date Published
    December 25, 2003
    20 years ago
Abstract
Human nucleic acid sequences—mRNA, cDNA, genomic sequences—from breast tumor tissue, which code for gene products or parts thereof, and their use, are described. In addition, the polypeptides that can be obtained by way of the sequences and their use are described.
Description


[0001] The invention relates to human nucleic acid sequences from breast tumor tissue, which code for gene products or parts thereof, their functional genes that code at least one bioactive polypeptide and their use.


[0002] In addition, the invention relates to the polypeptides that can be obtained via the sequences and their use.


[0003] One of the main causes of death in women is breast cancer, for control of which new therapies are necessary. Previously used therapies, such as, e.g., chemotherapy, hormone therapy or surgical removal of tumor tissue, frequently do not result in a complete cure.


[0004] The cancer phenomenon often goes along with overexpression or underexpression of certain genes in degenerated cells, it still being unclear whether these altered expression rates are the cause or the result of the malignant transformation. Identification of these genes would be an important step for development of new therapies against cancer. Spontaneous formation of cancer is often preceded by a host of mutations. They can have the most varied effects on the expression pattern in the affected tissue, such as, e.g., underexpression or overexpression, but also expression of shortened genes. Several such changes due to these mutation cascades can ultimately lead to malignant degeneration. The complexity of these relationships makes an experimental approach very difficult.


[0005] A database that consists of so-called ESTs is used to look for tumor-related candidate genes, i.e., genes that can be considered as the cause or the result of malignant degenerations in normal human tissue. ESTs (expressed sequence tags) are sequences of cDNAs, i.e., mRNAs transcribed in reverse, therefore molecules that reflect gene expression. The EST sequences are determined for normal and degenerated tissue. These databases are offered to some extent commercially by various companies. The ESTs of the LifeSeq database, which is used here, are generally between 150 and 350 nucleotides long. They represent a pattern that is unmistakable for a certain gene, although this gene is normally very much longer (>2000 nucleotides). By comparison of the expression patterns of normal and tumor tissue, ESTs can be identified which are important for tumor formation and proliferation. There is, however, the following problem: Since the EST sequences that are found can belong to different regions of an unknown gene due to different constructions of cDNA libraries, in this case a completely incorrect ratio of the occurrence of these ESTs in the respective tissue would arise. This would only be noticed when the complete gene is known and thus ESTs can be assigned to the same gene.


[0006] It has now been found that this error possibility can be reduced if all ESTs from the respective tissue type are assembled beforehand, before the expression patterns are compared to one another. Overlapping ESTs of the same gene were thus combined into longer sequences (see FIG. 1, FIG. 2a and FIG. 3). This lengthening and thus coverage of an essentially larger gene region in each of the respective bases are intended to largely avoid the above-described error. Since there were no existing software products for this purpose, programs for assembling genomic sections were employed, which were used modified and to which our own programs were added. A flow chart of the assembly procedure is shown in FIGS. 2b1-2b4.


[0007] Nucleic acid sequences Seq. ID No. 2-67, 149-161, and 201-202, which play a part as candidate genes in breast tumors, have now been found.


[0008] Nucleic acid sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161 are of special interest.


[0009] The invention thus relates to nucleic acid sequences that code a gene product or a part thereof, comprising


[0010] a) a nucleic acid sequence selected from the group of nucleic acid sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, 160-161


[0011] b) an allelic variation of the nucleic acid sequences named under a) or


[0012] c) a nucleic acid sequence that is complementary to the nucleic acid sequences named under a) or b).


[0013] In addition, the invention relates to a nucleic acid sequence according to one of the sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161 or a complementary or allelic variant thereof and the nucleic acid sequences thereof, which have 90% to 95% homology to a human nucleic acid sequence.


[0014] The invention also relates to nucleic acid sequences Seq. ID No. 2 to Seq. ID No. 67 as well as Seq. ID No. 149 to Seq. ID No. 201-202, which are expressed elevated in breast tumor tissue.


[0015] The invention further relates to nucleic acid sequences comprising a portion of the above-mentioned nucleic acid sequences in such a sufficient amount that they hybridize with sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159 and 160-161.


[0016] The nucleic acid sequences according to the invention generally have a length of at least 50 to 4500 bp, preferably a length of at least 150 to 4000 bp, especially a length of 450 to 3500 bp.


[0017] With the partial sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161 according to the invention, expression cassettes can also be built using current process practice, whereby on the cassette at least one of the nucleic acid sequences according to the invention is combined with at least one control or regulatory sequence generally known to one skilled in the art, such as, e.g., a suitable promoter. The sequences according to the invention can be inserted in a sense or antisense orientation.


[0018] A large number of expression cassettes or vectors and promoters which can be used are known in the literature.


[0019] Expression cassettes or vectors are defined as:


[0020] 1. bacterial, such as, e.g., phagescript, pBs, φX174, pBluescript SK, pBs KS, pNH8a, pNH16a, pNH18a, pNH46a (Stratagene), pTrc99A, pKK223-3, pKK233-3, pDR540, pRIT5 (Pharmacia), 2. eukaryotic, such as, e.g., pWLneo, pSV2cat, pOG44, pXT1, pSG (Stratagene), pSVK3, pBPV, pMSG, pSVL (Pharmacia).


[0021] A control or regulatory sequence is defined as suitable promoters. Here, two preferred vectors are the pKK232-8 and the PCM7 vector. In particular, the following promoters are intended: lacI, lacZ, T3, T7, gpt, lambda PR, trc, CMV, HSV thymidine-kinase, SV40, LTRs from retrovirus and mouse metallothionein-I.


[0022] The DNA sequences located on the expression cassette can code a fusion protein which comprises a known protein and a bioactive polypeptide fragment.


[0023] The expression cassettes are likewise the subject matter of this invention.


[0024] The nucleic acid fragments according to the invention can be used to produce full-length genes. The genes that can be obtained are likewise the subject matter of this invention.


[0025] The invention also relates to the use of the nucleic acid sequences according to the invention and the gene fragments that can be obtained from use.


[0026] The nucleic acid sequences according to the invention can be moved with suitable vectors into host cells, in which as the heterologous part, the genetic information which is contained on the nucleic acid fragments and which is expressed is located.


[0027] The host cells containing the nucleic acid fragments are likewise the subject matter of this invention.


[0028] Suitable host cells are, e.g., prokaryotic cell systems such as E. coli or eukaryotic cell systems such as animal or human cells or yeasts.


[0029] The nucleic acid sequences according to the invention can be used in the sense or antisense form.


[0030] Production of polypeptides or their fragments is done by cultivation of the host cells according to current cultivation methods and subsequent isolation and purification of the peptides or fragments, likewise using current methods. The invention further relates to nucleic acid sequences, which code at least a partial sequence of a bioactive polypeptide.


[0031] This invention further relates to polypeptide partial sequences, so-called ORF (open-reading-frame)-peptides according to the sequence protocols Seq. ID No. 71-79, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198.


[0032] The invention further relates to the polypeptide sequences that have at least 80% homology, especially 90% homology to the polypeptide partial sequences of Seq. ID No. 71-179, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198 according to the invention.


[0033] The invention also relates to antibodies that are directed against a polypeptide or a fragment thereof and that are coded by the nucleic acids of sequences Seq. ID No. 71-79, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198 according to the invention.


[0034] Antibodies are defined especially as monoclonal antibodies.


[0035] The polypeptides of sequences Seq. ID No. 71-79, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198 according to the invention can also be used as tools for finding active ingredients against breast cancer, which is likewise the subject matter of this invention.


[0036] Likewise the subject matter of this invention is the use of nucleic acid sequences according to sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161 for expression of polypeptides, which can be used as tools for finding active ingredients against breast cancer.


[0037] The invention also relates to the use of the found polypeptide partial sequences Seq. ID No. 71-79, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198 for the production of a pharmaceutical agent for treatment of breast cancer.


[0038] The invention also relates to pharmaceutical agents that contain at least one polypeptide partial sequence Seq. ID No. 71-79, 81-117, 119-121, 123, 126, 128-147, 162-168, 172, 174, 177-180, 183-185, 187, 190, and 192-198.


[0039] The nucleic acid sequences found according to the invention can also be genomic or mRNA sequences.


[0040] The invention also relates to genomic genes, their exon and intron structures and their splice versions that can be obtained from cDNAs of sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161, and their use together with suitable regulatory elements, such as suitable promoters and/or enhancers.


[0041] With the nucleic acids according to the invention (cDNA sequences), genomic BAC, PAC and Cosmid libraries are screened and specifically human clones are isolated via complementary base pairing (hybridization). The BAC, PAC and Cosmid clones isolated in this way are hybridized using fluorescence-in-situ hybridization on metaphase chromosomes and the corresponding chromosome sections on which the corresponding genomic genes lie are identified. BAC, PAC and Cosmid clones are sequenced in order to clarify the corresponding genomic genes in their complete structure (promoters, enhancers, silencers, exons and introns). BAC, PAC and Cosmid clones can be used as independent molecules for gene transfer (see FIG. 5).


[0042] The invention also relates to BAC, PAC and Cosmid clones containing functional genes and their chromosomal localization according to sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 155-159, and 160-161 for use as vehicles for gene transfer.


[0043] Meanings of Technical Terms and Abbreviations


[0044] Nucleic acids=Nucleic acids in this invention are defined as: mRNA, partial cDNA, full-length cDNA and genomic genes (chromosomes).


[0045] ORF=Open Reading Frame, a defined sequence of amino acids which can be derived from the cDNA sequence.


[0046] Contig=A set of DNA sequences that can be combined as a result of very great similarities into one sequence (consensus).


[0047] Singleton=A contig that contains only one sequence.


[0048] Module=Domain of a protein with a defined sequence, which represents one structural unit and which occurs in various proteins.


[0049] N=selectively the nucleotide A, T, G or C.


[0050] X=selectively one of the 20 naturally occurring amino acids.


[0051] Explanation of the Alignment Parameters


[0052] minimal initial match=minimal initial identity area


[0053] maximum pads per read=maximum number of insertions


[0054] maximum percent mismatch=maximum deviation in %






EXPLANATION OF FIGURES

[0055]
FIG. 1 shows the systematic gene search in the Incyte LifeSeq database.


[0056]
FIG. 2

a
shows the principle of EST assembling


[0057]
FIGS. 2

b


1
-2b4 show the entire principle of EST assembling


[0058]
FIG. 3 shows the in-silico subtraction of gene expression in various tissues


[0059]
FIG. 4

a
shows the determination of tissue-specific expression via electronic Northern


[0060]
FIG. 4

b
shows the electronic Northern


[0061]
FIG. 5 shows the isolation of genomic BAC and PAC clones.







[0062] The following examples explain the production of the nucleic acid sequences according to the invention without limiting the invention to these examples and nucleic acid sequences.


EXAMPLE 1

[0063] Search for Tumor-Related Candidate Genes


[0064] First, all ESTs of the corresponding tissue from the LifeSeq database (from October 1997) were extracted. They were then assembled by means of the GAP4 program of the Staden package with the parameters 0% mismatch, 8 pads per read and a minimal match of 20. The sequences (fails) not recorded in the GAP4 database were assembled first at 1% mismatch and then again at 2% mismatch with the database. Consensus sequences were computed from the contigs of the database that consisted of more than one sequence.


[0065] The singletons of the database, which consisted of only one sequence, were re-assembled at 2% mismatch with the sequences not recorded in the GAP4 database. In turn, the consensus sequences were determined for the contigs. All other ESTs were re-assembled at 4% mismatch. The consensus sequences were extracted once again and finally assembled with the previous consensus sequences and the singletons and the sequences not recorded in the database at 4% mismatch. The consensus sequences were formed and used with the singletons and fails as the initial basis for tissue comparisons. This procedure ensured that among the parameters used, all sequences represented gene regions independent of one another.


[0066]
FIGS. 2

b


1
-2b4 illustrate the lengthening of the breast tumor tissue ESTs.


[0067] The sequences of the respective tissue assembled in this way were then compared to one another by means of the same program (FIG. 3). To do this, first all sequences of the first tissue were input into the database. (It was therefore important that they were independent of one another).


[0068] Then, all sequences of the second tissue were compared to all those of the first. The result was sequences that were specific to the first or the second tissue as well as those which occurred in both. In the latter, the ratio of the frequency of occurrence in the respective tissue was evaluated. All programs pertaining to the evaluation of the assembled sequences were themselves developed.


[0069] All sequences that occurred more than four times in respectively one of the compared tissues and all that occurred at least five times as often in one of the two tissues were further studied. These sequences were subjected to an electronic Northern (see Example 2.1), by which the distribution in all tumor and normal tissues was studied (see FIG. 4a and FIG. 4b). The relevant candidates were then lengthened using all Incyte ESTs and all ESTs of public databases (see Example 3). Then, the sequences and their translation into possible proteins were compared to all nucleotide and protein databases and were studied for possible regions that code for proteins.



EXAMPLE 2

[0070] Algorithm for Identification and Lengthening of Partial cDNA Sequences with Altered Expression Pattern


[0071] An algorithm for finding overexpressed or underexpressed genes will be explained below. The individual steps are also summarized in a flow chart for the sake of clarity (see FIG. 4b).


[0072] 2.1. Electronic Northern Blot


[0073] By means of a standard program for homology search, e.g., BLAST (Altschul, S. F.; Gish, W.; Miller, W.; Myers, E. W. and Lipman, D. J. (1990) J. Mol. Biol. 215, 403-410), BLAST2 (Altschul, S. F.; Madden, T. L.; Schäffer, A. A.; Zhang, J.; Zhang, Z.; Miller, W., and Lipman, D. J. (1997) Nucleic Acids Research 25 3389-3402) or FASTA (Pearson, W. R. and Lipman, D. J. (1988) Proc. Natl. Acad. Sci. USA 85 2444-2448), the homologous sequences in various EST libraries (private or public) arranged by tissues are determined for a partial DNA sequence S, e.g., an individual EST or a contig of ESTs. The (relative or absolute) tissue-specific occurrence frequencies of this partial sequence S which were determined in this way are called electronic Northern Blots.


[0074] 2.1.1


[0075] Analogously to the procedure described under 2.1, the sequence Seq. ID No. 2 was found which occurs 9× more heavily in breast tumor tissue than in normal tissue.


[0076] The possible function of this gene region relates to a 17-kDa-interferon-inducible gene.


[0077] The result is as follows:
1Electronic Northern for Seq. ID NO.: 2TU-MORRATIOS% freq.% freq.N/TT/NNORMALBladder0.00000.01020.0000undefBreast0.00530.04580.11658.5843Ovary0.00300.03380.089911.1243 Endocrine tissue0.00000.0000undefundefGastrointestinal0.00390.01430.27143.6843Brain0.00850.00990.86011.1626Hematopoietic0.00280.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.0000undefundefHeart0.00740.0000undef0.0000Testicles0.00000.01170.0000undefLungs0.00370.00241.58010.6329Stomach-esophagus0.00970.00771.25990.7937Muscle-skeleton0.00340.01200.28553.5025Kidneys0.00300.0000undef0.0000Pancreas0.00380.0000undef0.0000Penis0.00300.10660.028135.6161 Prostate0.00480.00431.11860.8939Uterus0.00830.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0093Prostatic hyperplasia0.0030Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0035FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0000Hematopoietic0.0039Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0228Endocrine tissue0.0000Fetal0.0082Gastrointestinal0.0244Hematopoietic0.0057Skin-muscle0.0032Testicles0.0000Lungs0.0082Nerves0.0010Prostate0.0128Sensory organs0.0000


[0078] 2.1.2


[0079] Analogously to the procedure described under 2.1, the sequence Seq. ID No. 5 was found which occurs 30× more heavily in breast tumor tissue than in normal tissue.


[0080] The possible function of this gene region relates to “macrophage migration inhibition factor related protein 14 (MRP-14).”


[0081] The result is as follows:
2Electronic Northern for Seq. ID NO.: 5TU-MORRATIOS% freq.% freq.N/TT/NNORMALBladder0.00930.15080.061616.2223 Breast0.00130.03920.034029.4320 Ovary0.01520.0000undef0.0000Endocrine tissue0.00180.00270.66981.4930Gastrointestinal0.01740.00483.66420.2729Brain0.00510.00550.92891.0765Hematopoietic0.09930.0000undef0.0000Skin0.02490.0000undef0.0000Hepatic0.00000.01290.0000undefHeart0.00530.0000undef0.0000Testicles0.00610.0000undef0.0000Lungs0.02610.03070.85081.1753Stomach-esophagus0.10620.02304.61970.2165Muscle-skeleton0.01710.01800.95171.0508Kidneys0.00000.00680.0000undefPancreas0.01140.0000undef0.0000Penis0.12580.16000.78621.2720Prostate0.00000.0000undefundefUterus0.08260.0000undef0.0000Breast hyperplasia0.0036Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0178Sensory organs0.0000White blood cells0.1018FETUSDevelopment0.0000Gastrointestinal0.0062Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0037Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0052Gastrointestinal0.0122Hematopoietic0.0057Skin-muscle0.0000Testicles0.0000Lungs0.0410Nerves0.0000Prostate0.0449Sensory organs0.0000


[0082] 2.1.3


[0083] Analogously to the procedure described under 2.1, the sequence Seq. ID No. 16 was found which occurs 30× more heavily in breast tumor tissue than in normal tissue.


[0084] The possible function of this gene region relates to human Tim23, which is located in the protein translocase complex of the inside mitochondrial membrane.


[0085] The result is as follows:
3Electronic Northern for Seq. ID NO.: 16TU-MORRATIOS% freq.% freq.N/TT/NNORMALBladder0.00460.00510.90921.0998Breast0.00130.01530.087411.4458 Ovary0.00000.00260.0000undefEndocrine tissue0.00910.00821.11630.8958Gastrointestinal0.01160.00951.22140.8187Brain0.00760.00551.39340.7177Hematopoietic0.00840.0000undef0.0000Skin0.01990.0000undef0.0000Hepatic0.01980.00653.06060.3267Heart0.01060.0000undef0.0000Testicles0.01830.0000undef0.0000Lungs0.01000.00244.21370.2373Stomach-esophagus0.01930.0000undef0.0000Muscle-skeleton0.00340.00600.57101.7513Kidneys0.00300.0000undef0.0000Pancreas0.00000.0000undefundefPenis0.00000.0000undefundefProstate0.00480.00850.55931.7879Uterus0.00170.00710.23214.3088Breast hyperplasia0.0073Small intestine0.0031Prostatic hyperplasia0.0030Seminal vesicles0.0089Sensory organs0.0118White blood cells0.0009FETUSDevelopment0.0154Gastrointestinal0.0000Brain0.0125Hematopoietic0.0000Heart-blood vessels0.0041Lungs0.0111Kidneys0.0000Prostate0.0499Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0068Endocrine tissue0.0000Fetal0.0064Gastrointestinal0.0244Hematopoietic0.0057Skin-muscle0.0065Testicles0.0156Lungs0.0164Nerves0.0030Prostate0.0000Sensory organs0.0000


[0086] In an analogous procedure, the following Northerns were also found:
4TU-MORRATIOS% freq.% freq.N/TT/NElectronic Northern for SEQ. ID NO.: 3NORMALBladder0.00460.01280.36372.7495Breast0.00670.01740.38222.6162Ovary0.00610.0000undef0.0000Endocrine tissue0.00180.00820.22334.4791Gastrointestinal0.00390.00480.81431.2281Brain0.03390.01103.09640.3230Hematopoietic0.01120.0000undef0.0000Skin0.01490.0000undef0.0000Hepatic0.00500.0000undef0.0000Heart0.00640.0000undef0.0000Testicles0.01830.0000undef0.0000Lungs0.01370.0000undef0.0000Stomach-esophagus0.00970.01530.63001.5874Muscle-skeleton0.00860.01200.71381.4010Kidneys0.00300.03420.086811.5165 Pancreas0.00570.01100.51431.9446Penis0.00300.0000undef0.0000Prostate0.00240.00850.27973.5758Uterus0.01160.00711.62460.6155Breast hyperplasia0.0036Small intestine0.0093Prostatic hyperplasia0.0030Seminal vesicles0.0000Sensory organs0.0118White blood cells0.0061FETUSDevelopment0.0000Gastrointestinal0.0092Brain0.0188Hematopoietic0.0079Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0204Ovary-uterus0.0091Endocrine tissue0.0000Fetal0.0093Gastrointestinal0.0000Hematopoietic0.0114Skin-muscle0.0227Testicles0.0000Lungs0.0082Nerves0.0291Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 4NORMALBladder0.00930.02560.36372.7495Breast0.01330.02830.47042.1256Ovary0.00910.01040.87651.1409Endocrine tissue0.02740.04900.55821.7916Gastrointestinal0.01160.00951.22140.8187Brain0.02120.01641.29020.7751Hematopoietic0.00840.0000undef0.0000Skin0.03480.0000undef0.0000Hepatic0.01490.02590.57391.7426Heart0.01910.01371.38730.7208Testicles0.01220.0000undef0.0000Lungs0.01620.01650.97821.0223Stomach-esophagus0.02900.01531.88990.5291Muscle-skeleton0.00690.01200.57101.7513Kidneys0.01780.00682.60500.3839Pancreas0.00380.02210.17145.8337Penis0.01800.0000undef0.0000Prostate0.02140.02340.91521.0926Uterus0.01820.02140.85101.1751Breast hyperplasia0.0073Small intestine0.0218Prostatic hyperplasia0.0357Seminal vesicles0.0178Sensory organs0.0118White blood cells0.0218FETUSDevelopment0.0000Gastrointestinal0.0154Brain0.0125Hematopoietic0.0000Heart-blood vessels0.0123Lungs0.0111Kidneys0.0124Prostate0.0499Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0183Endocrine tissue0.0000Fetal0.0076Gastrointestinal0.0488Hematopoietic0.0000Skin-muscle0.0259Testicles0.0000Lungs0.0000Nerves0.0090Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 6NORMALBladder0.00000.01020.0000undefBreast0.00530.01960.27183.6790Ovary0.00610.00521.16860.8557Endocrine tissue0.00180.00270.66981.4930Gastrointestinal0.00390.00950.40712.4562Brain0.00760.00332.32230.4306Hematopoietic0.00420.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.00990.01290.76511.3069Heart0.00640.0000undef0.0000Testicles0.00000.01170.0000undefLungs0.00500.01420.35112.8478Stomach-esophagus0.00000.02300.0000undefMuscle-skeleton0.00340.0000undef0.0000Kidneys0.01190.01370.86831.1517Pancreas0.00380.00550.68571.4584Penis0.00300.0000undef0.0000Prostate0.01670.01281.30510.7662Uterus0.00330.01420.23214.3088Breast hyperplasia0.0036Small intestine0.0062Prostatic hyperplasia0.0119Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0009FETUSDevelopment0.0154Gastrointestinal0.0062Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0041Lungs0.0037Kidneys0.0062Prostate0.0249Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0023Endocrine tissue0.0000Fetal0.0047Gastrointestinal0.0122Hematopoietic0.0057Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0000Prostate0.0256Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 7NORMALBladder0.01860.00513.63700.2750Breast0.01470.02610.56061.7838Ovary0.01820.02340.77911.2836Endocrine tissue0.04560.02451.86050.5375Gastrointestinal0.02330.01901.22140.8187Brain0.03140.02301.36390.7332Hematopoietic0.01960.03780.51751.9325Skin0.01990.0000undef0.0000Hepatic0.00500.03880.12757.8416Heart0.03280.02751.19470.8371Testicles0.01830.03510.52241.9144Lungs0.01490.02840.52671.8986Stomach-esophagus0.01930.04600.42002.3811Muscle-skeleton0.02230.04800.46392.1554Kidneys0.02080.02051.01300.9871Pancreas0.02460.00554.45690.2244Penis0.04490.02671.68460.5936Prostate0.01670.03830.43502.2987Uterus0.02310.02141.08310.9233Breast hyperplasia0.0109Small intestine0.0125Prostatic hyperplasia0.0357Seminal vesicles0.0356Sensory organs0.0000White blood cells0.0165FETUSDevelopment0.0307Gastrointestinal0.0247Brain0.0375Hematopoietic0.0118Heart-blood vessels0.0204Lungs0.0296Kidneys0.0185Prostate0.0249Sensory organs0.0279STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0068Ovary-uterus0.0068Endocrine tissue0.0000Fetal0.0093Gastrointestinal0.0000Hematopoietic0.0114Skin-muscle0.0097Testicles0.0078Lungs0.0082Nerves0.0100Prostate0.0000Sensory organs0.0155Electronic Northern for SEQ. ID NO.: 8NORMALBladder0.01390.02810.49592.0163Breast0.00800.04140.19315.1778Ovary0.01220.02600.46742.1393Endocrine tissue0.02740.03540.77281.2940Gastrointestinal0.02520.03330.75611.3226Brain0.02370.01751.35470.7382Hematopoietic0.00980.0000undef0.0000Skin0.01490.16930.088111.3508Hepatic0.01490.01291.14770.8713Heart0.03810.04120.92491.0812Testicles0.01830.0000undef0.0000Lungs0.01740.06150.28363.5259Stomach-esophagus0.00970.03830.25203.9685Muscle-skeleton0.01710.01800.95171.0508Kidneys0.02080.05480.37992.6323Pancreas0.02840.0000undef0.0000Penis0.01800.10660.16855.9360Prostate0.01190.02130.55931.7879Uterus0.01160.02850.40612.4622Breast hyperplasia0.0109Small intestine0.0374Prostatic hyperplasia0.0386Seminal vesicles0.0356Sensory organs0.0000White blood cells0.0113FETUSDevelopment0.0307Gastrointestinal0.0216Brain0.0188Hematopoietic0.0079Heart-blood vessels0.0245Lungs0.0259Kidneys0.0062Prostate0.0748Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0068Ovary-uterus0.0205Endocrine tissue0.0000Fetal0.0233Gastrointestinal0.0366Hematopoietic0.0000Skin-muscle0.0615Testicles0.0078Lungs0.0164Nerves0.0181Prostate0.0192Sensory organs0.0387Electronic Northern for SEQ. ID NO.: 9NORMALBladder0.00460.01280.36372.7495Breast0.00530.02180.24464.0878Ovary0.01220.00264.67450.2139Endocrine tissue0.00360.01090.33492.9861Gastrointestinal0.02130.00484.47840.2233Brain0.00510.0000undef0.0000Hematopoietic0.00280.0000undef0.0000Skin0.03480.0000undef0.0000Hepatic0.02970.0000undef0.0000Heart0.00640.01370.46242.1624Testicles0.00000.0000undefundefLungs0.03240.01891.71180.5842Stomach-esophagus0.00000.00770.0000undefMuscle-skeleton0.00170.0000undef0.0000Kidneys0.03570.0000undef0.0000Pancreas0.02080.0000undef0.0000Penis0.00000.0000undefundefProstate0.02140.00852.51690.3973Uterus0.00500.0000undef0.0000Breast hyperplasia0.0145Small intestine0.0031Prostatic hyperplasia0.0178Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0000FETUSDevelopment0.0000Gastrointestinal0.0062Brain0.0000Hematopoietic0.0039Heart-blood vessels0.0041Lungs0.0148Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0068Endocrine tissue0.0000Fetal0.0058Gastrointestinal0.0244Hematopoietic0.0000Skin-muscle0.0130Testicles0.0000Lungs0.0246Nerves0.0020Prostate0.0256Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 11NORMALBladder0.01390.01790.77931.2831Breast0.01330.04140.32193.1067Ovary0.00000.01560.0000undefEndocrine tissue0.00730.00272.67910.3733Gastrointestinal0.00580.00481.22140.8187Brain0.00930.01530.60821.6441Hematopoietic0.00980.0000undef0.0000Skin0.01990.0000undef0.0000Hepatic0.00500.01290.38262.6139Heart0.00850.01370.61661.6218Testicles0.00610.01170.52241.9144Lungs0.02370.02131.11200.8993Stomach-esophagus0.00970.00771.25990.7937Muscle-skeleton0.01030.01800.57101.7513Kidneys0.00300.04790.062016.1231 Pancreas0.00380.02210.17145.8337Penis0.00900.05330.16855.9360Prostate0.00710.00850.83901.1919Uterus0.00500.02140.23214.3088Breast hyperplasia0.0182Small intestine0.0062Prostatic hyperplasia0.0000Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0331FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0340Ovary-uterus0.0023Endocrine tissue0.0000Fetal0.0006Gastrointestinal0.0000Hematopoietic0.0057Skin-muscle0.0032Testicles0.0000Lungs0.0656Nerves0.0030Prostate0.0000Sensory organs0.0387Electronic Northern for SEQ. ID NO.: 12NORMALBladder0.00930.00263.63700.2750Breast0.01600.05450.29363.4065Ovary0.00610.00780.77911.2836Endocrine tissue0.00910.00821.11630.8958Gastrointestinal0.00190.0000undef0.0000Brain0.00340.0000undef0.0000Hematopoietic0.00140.0000undef0.0000Skin0.01490.0000undef0.0000Hepatic0.00000.0000undefundefHeart0.00210.02750.077112.9744 Testicles0.00610.0000undef0.0000Lungs0.00250.0000undef0.0000Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00340.0000undef0.0000Kidneys0.00890.0000undef0.0000Pancreas0.00190.0000undef0.0000Penis0.01200.0000undef0.0000Prostate0.00480.01060.44752.2349Uterus0.00660.0000undef0.0000Breast hyperplasia0.0218Small intestine0.0000Prostatic hyperplasia0.0238Seminal vesicles0.0000Sensory organs0.0235White blood cells0.0044FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0125Hematopoietic0.0039Heart-blood vessels0.0000Lungs0.0074Kidneys0.0000Prostate0.0249Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0046Endocrine tissue0.0000Fetal0.0041Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0070Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 13NORMALBladder0.01860.01281.45480.6874Breast0.00930.02830.32933.0366Ovary0.01220.00264.67450.2139Endocrine tissue0.02370.01361.74140.5742Gastrointestinal0.02710.0000undef0.0000Brain0.00680.01200.56301.7762Hematopoietic0.00840.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.01980.00653.06060.3267Heart0.03070.02751.11760.8948Testicles0.01220.02340.52241.9144Lungs0.01250.00472.63360.3797Stomach-esophagus0.02900.02301.25990.7937Muscle-skeleton0.00860.01800.47582.1015Kidneys0.01190.01370.86831.1517Pancreas0.00380.01660.22864.3753Penis0.05390.0000undef0.0000Prostate0.02140.03410.62921.5892Uterus0.04460.01423.13310.3192Breast hyperplasia0.0036Small intestine0.0093Prostatic hyperplasia0.0149Seminal vesicles0.0534Sensory organs0.0000White blood cells0.0104FETUSDevelopment0.0307Gastrointestinal0.0308Brain0.0063Hematopoietic0.0039Heart-blood vessels0.0082Lungs0.0370Kidneys0.0062Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0204Ovary-uterus0.0114Endocrine tissue0.0245Fetal0.0099Gastrointestinal0.0000Hematopoietic0.0285Skin-muscle0.0130Testicles0.0000Lungs0.0082Nerves0.0110Prostate0.0128Sensory organs0.0155Electronic Northern for SEQ. ID NO.: 14NORMALBladder0.00000.00770.0000undefBreast0.00800.02610.30583.2702Ovary0.00610.02340.25973.8507Endocrine tissue0.00730.01630.44652.2395Gastrointestinal0.00780.00481.62850.6141Brain0.00760.00770.99531.0047Hematopoietic0.01820.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.03880.0000undefHeart0.00420.0000undef0.0000Testicles0.00610.0000undef0.0000Lungs0.01250.01650.75241.3290Stomach-esophagus0.00970.01530.63001.5874Muscle-skeleton0.00340.0000undef0.0000Kidneys0.01490.01371.08540.9213Pancreas0.00190.00550.34282.9168Penis0.00900.02670.33692.9680Prostate0.05240.03411.53810.6501Uterus0.00660.0000undef0.0000Breast hyperplasia0.0036Small intestine0.0062Prostatic hyperplasia0.0386Seminal vesicles0.0000Sensory organs0.0235White blood cells0.0113FETUSDevelopment0.0154Gastrointestinal0.0092Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0041Lungs0.0259Kidneys0.0247Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0183Endocrine tissue0.0000Fetal0.0181Gastrointestinal0.0366Hematopoietic0.0285Skin-muscle0.0324Testicles0.0078Lungs0.0246Nerves0.0020Prostate0.0705Electronic Northern for SEQ. ID NO.: 15NORMALBladder0.00930.01020.90921.0998Breast0.00270.01960.13597.3580Ovary0.00000.02340.0000undefEndocrine tissue0.00550.03810.14356.9675Gastrointestinal0.00580.01430.40712.4562Brain0.00760.00661.16120.8612Hematopoietic0.00840.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.0000undefundefHeart0.02010.0000undef0.0000Testicles0.01220.0000undef0.0000Lungs0.01000.01650.60201.6612Stomach-esophagus0.00000.01530.0000undefMuscle-skeleton0.00170.00600.28553.5025Kidneys0.01190.01370.86831.1517Pancreas0.00380.0000undef0.0000Penis0.01200.0000undef0.0000Prostate0.00950.01280.74581.3409Uterus0.00660.01420.46422.1544Breast hyperplasia0.0036Small intestine0.0187Prostatic hyperplasia0.0089Seminal vesicles0.0356Sensory organs0.0118White blood cells0.0052FETUSDevelopment0.0000Gastrointestinal0.0123Brain0.0188Hematopoietic0.0118Heart-blood vessels0.0123Lungs0.0185Kidneys0.0124Prostate0.0000Sensory organs0.0140STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0068Endocrine tissue0.0000Fetal0.0064Gastrointestinal0.0122Hematopoietic0.0057Skin-muscle0.0130Testicles0.0312Lungs0.0164Nerves0.0070Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 17NORMALBladder0.00460.00770.60621.6497Breast0.00400.02400.16685.9954Ovary0.00300.01300.23374.2786Endocrine tissue0.00180.0000undef0.0000Gastrointestinal0.02710.00952.84990.3509Brain0.00000.0000undefundefHematopoietic0.00420.0000undef0.0000Skin0.04480.0000undef0.0000Hepatic0.00000.0000undefundefHeart0.00000.0000undefundefTesticles0.00000.02340.0000undefLungs0.00870.00711.22900.8137Stomach-esophagus0.08690.02303.77980.2646Muscle-skeleton0.00000.0000undefundefKidneys0.00000.0000undefundefPancreas0.00000.0000undefundefPenis0.01800.05330.33692.9680Prostate0.00480.00212.23730.4470Uterus0.01160.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0125Prostatic hyperplasia0.0000Seminal vesicles0.0089Sensory organs0.0118While blood cells0.0000FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0039Heart-blood vessels0.0000Lungs0.0074Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0000Gastrointestinal0.0000Hematopoietic0.0057Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0000Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 18NORMALBladder0.00000.00770.0000undefBreast0.00270.01960.13597.3580Ovary0.00300.02080.14616.8457Endocrine tissue0.01820.01091.67450.5972Gastrointestinal0.00190.0000undef0.0000Brain0.00510.00990.51611.9377Hematopoietic0.00280.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00500.00650.76511.3069Heart0.00850.0000undef0.0000Testicles0.00000.01170.0000undefLungs0.01000.00711.40460.7120Stomach-esophagus0.00970.0000undef0.0000Muscle-skeleton0.01880.00603.14060.3184Kidneys0.00300.0000undef0.0000Pancreas0.00000.00550.0000undefPenis0.00900.05330.16855.9360Prostate0.01910.01061.78980.5587Uterus0.01160.00711.62460.6155Breast hyperplasia0.0036Small intestine0.0062Prostatic hyperplasia0.0208Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0044FETUSDevelopment0.0154Gastrointestinal0.0062Brain0.0000Hematopoietic0.0118Heart-blood vessels0.0245Lungs0.0074Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0136Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0082Gastrointestinal0.0122Hematopoietic0.0456Skin-muscle0.0097Testicles0.0078Lungs0.0164Nerves0.0050Prostate0.0064Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 19NORMALBladder0.00000.0000undefundefBreast0.01200.07630.15736.3588Ovary0.06080.02342.59690.3851Endocrine tissue0.00730.02450.29773.3593Gastrointestinal0.08720.10000.87241.1462Brain0.00170.0000undef0.0000Hematopoietic0.00140.0000undef0.0000Skin0.00000.0000undefundefHepatic0.01490.03880.38262.6139Heart0.00110.0000undef0.0000Testicles0.00000.0000undefundefLungs0.00500.03550.14057.1196Stomach-esophagus0.00000.02300.0000undefMuscle-skeleton0.00000.0000undefundefKidneys0.00000.0000undefundefPancreas0.00000.01660.0000undefPenis0.00000.0000undefundefProstate0.01190.09580.12438.0455Uterus0.00170.02140.077412.9263 Breast hyperplasia0.0073Small intestine0.0436Prostatic hyperplasia0.0119Seminal vesicles0.0089Sensory organs0.0470White blood cells0.0009FETUSDevelopment0.0000Gastrointestinal0.0247Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0205Endocrine tissue0.0000Fetal0.0052Gastrointestinal0.0366Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0000Prostate0.0321Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 20NORMALBladder0.00000.00510.0000undefBreast0.00400.02400.16685.9954Ovary0.01820.00782.33720.4279Endocrine tissue0.01640.02450.66981.4930Gastrointestinal0.02130.01901.11960.8932Brain0.01440.01860.77411.2918Hematopoietic0.00560.0000undef0.0000Skin0.00000.0000undefundefHepatic0.02480.00653.82570.2614Heart0.01380.0000undef0.0000Testicles0.04280.0000undef0.0000Lungs0.01990.01651.20390.8306Stomach-esophagus0.00970.02300.42002.3811Muscle-skeleton0.01200.0000undef0.0000Kidneys0.01190.01370.86831.1517Pancreas0.00380.0000undef0.0000Penis0.01500.0000undef0.0000Prostate0.01190.01920.62151.6091Uterus0.01320.01420.92831.0772Breast hyperplasia0.0254Small intestine0.0093Prostatic hyperplasia0.0238Seminal vesicles0.0178Sensory organs0.0118White blood cells0.0044FETUSDevelopment0.0000Gastrointestinal0.0062Brain0.0125Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0111Kidneys0.0185Prostate0.0000Sensory organs0.0140STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0068Endocrine tissue0.0000Fetal0.0058Gastrointestinal0.0488Hematopoietic0.0114Skin-muscle0.0065Testicles0.0000Lungs0.0000Nerves0.0040Prostate0.0385Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 21NORMALBladder0.00000.00260.0000undefBreast0.00670.02610.25483.9243Ovary0.00000.0000undefundefEndocrine tissue0.00180.0000undef0.0000Gastrointestinal0.00390.00480.81431.2281Brain0.00170.00220.77411.2918Hematopoietic0.01120.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.00000.00650.0000undefHeart0.00420.01370.30833.2436Testicles0.00000.0000undefundefLungs0.00370.00241.58010.6329Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00340.0000undef0.0000Kidneys0.00300.01370.21714.6066Pancreas0.00000.00550.0000undefPenis0.00600.0000undef0.0000Prostate0.00240.0000undef0.0000Uterus0.00170.0000undef0.0000Breast hyperplasia0.0073Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0052FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0039Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0068Ovary-uterus0.0046Endocrine tissue0.0000Fetal0.0023Gastrointestinal0.0000Hematopoietic0.0228Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0000Prostate0.0064Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 22NORMALBladder0.00460.00510.90921.0998Breast0.00930.02180.42812.3359Ovary0.00610.00780.77911.2836Endocrine tissue0.00550.0000undef0.0000Gastrointestinal0.00390.0000undef0.0000Brain0.00590.00331.80620.5536Hematopoietic0.01260.0000undef0.0000Skin0.00500.08470.058717.0262 Hepatic0.00500.0000undef0.0000Heart0.01380.01371.00200.9980Testicles0.00610.0000undef0.0000Lungs0.01120.00244.74040.2110Stomach-esophagus0.00970.05370.18005.5559Muscle-skeleton0.00860.01800.47582.1015Kidneys0.01190.02740.43422.3033Pancreas0.00570.0000undef0.0000Penis0.00300.02670.11238.9040Prostate0.01430.00433.35590.2980Uterus0.00330.00710.46422.1544Breast hyperplasia0.0036Small intestine0.0062Prostatic hyperplasia0.0089Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0070FETUSDevelopment0.0000Gastrointestinal0.0092Brain0.0125Hematopoietic0.0157Heart-blood vessels0.0041Lungs0.0037Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0114Endocrine tissue0.0000Fetal0.0029Gastrointestinal0.0000Hematopoietic0.0114Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0020Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 23NORMALBladder0.00000.00770.0000undefBreast0.00400.01310.30583.2702Ovary0.00300.0000undef0.0000Endocrine tissue0.01090.0000undef0.0000Gastrointestinal0.01360.00482.84990.3509Brain0.00590.00990.60211.6609Hematopoietic0.00560.0000undef0.0000Skin0.05970.0000undef0.0000Hepatic0.00000.00650.0000undefHeart0.00640.01370.46242.1624Testicles0.00000.03510.0000undefLungs0.00120.00950.13177.5943Stomach-esophagus0.01930.02300.83991.1905Muscle-skeleton0.00690.00601.14200.8756Kidneys0.00590.00680.86831.1517Pancreas0.00380.0000undef0.0000Penis0.00000.0000undefundefProstate0.01430.02130.67121.4899Uterus0.00660.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0093Prostatic hyperplasia0.0089Seminal vesicles0.0178Sensory organs0.0118White blood cells0.0044FETUSDevelopment0.0154Gastrointestinal0.0031Brain0.0250Hematopoietic0.0000Heart-blood vessels0.0245Lungs0.0037Kidneys0.0185Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0136Ovary-uterus0.0297Endocrine tissue0.0000Fetal0.0222Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0082Nerves0.0030Prostate0.0064Sensory organs0.0077Electronic Northern for SEQ. ID NO.: 24NORMALBladder0.00460.01020.45462.1996Breast0.00270.01740.15296.5404Ovary0.01520.02340.64921.5403Endocrine tissue0.01460.03270.44652.2395Gastrointestinal0.02910.00953.05350.3275Brain0.02030.02520.80781.2380Hematopoietic0.00840.0000undef0.0000Skin0.01490.0000undef0.0000Lungs0.01370.01181.15880.8630Stomach-esophagus0.00970.01530.63001.5874Muscle-skeleton0.02060.00603.42610.2919Kidneys0.03270.04110.79601.2563Pancreas0.01140.02210.51431.9446Penis0.03290.0000undef0.0000Prostate0.02860.02341.22030.8195Uterus0.01650.00712.32080.4309Breast hyperplasia0.0145Small intestine0.0187Prostatic hyperplasia0.0119Seminal vesicles0.0178Sensory organs0.0000White blood cells0.0122FETUSDevelopment0.0000Gastrointestinal0.0154Brain0.0313Hematopoietic0.0039Heart-blood vessels0.0368Lungs0.0111Kidneys0.0124Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0228Endocrine tissue0.0245Fetal0.0035Gastrointestinal0.0244Hematopoietic0.0171Skin-muscle0.0000Testicles0.0156Lungs0.0246Nerves0.0090Prostate0.0192Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 25NORMALBladder0.00000.00510.0000undefBreast0.00400.01310.30583.2702Ovary0.00000.00520.0000undefEndocrine tissue0.00360.00271.33960.7465Gastrointestinal0.00390.00480.81431.2281Brain0.01020.00771.32700.7536Hematopoietic0.00840.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.0000undefundefHeart0.00000.01370.0000undefTesticles0.00000.0000undefundefLungs0.00120.00470.26343.7971Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00340.02400.14287.0051Kidneys0.00590.00680.86831.1517Pancreas0.00000.0000undefundefPenis0.00300.02670.11238.9040Prostate0.00000.00640.0000undefUterus0.00170.00710.23214.3088Breast hyperplasia0.0036Small intestine0.0062Prostatic hyperplasia0.0059Seminal vesicles0.0000Sensory organs0.0118White blood cells0.0026FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0111Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0000Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0040Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 27NORMALBladder0.00930.00771.21230.8249Breast0.00670.01310.50961.9621Ovary0.00000.0000undefundefEndocrine tissue0.00180.0000undef0.0000Gastrointestinal0.00190.0000undef0.0000Brain0.00420.01750.24194.1338Hematopoietic0.00280.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.00000.0000undefundefHeart0.00640.04120.15416.4872Testicles0.00610.0000undef0.0000Lungs0.00620.0000undef0.0000Stomach-esophagus0.00000.01530.0000undefMuscle-skeleton0.00170.01200.14287.0051Kidneys0.00890.0000undef0.0000Pancreas0.00380.0000undef0.0000Penis0.00000.02670.0000undefProstate0.00950.00214.47450.2235Uterus0.00330.01420.23214.3088Breast hyperplasia0.0036Small intestine0.0000Prostatic hyperplasia0.0030Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0009FETUSDevelopment0.0307Gastrointestinal0.0062Brain0.0250Hematopoietic0.0197Heart-blood vessels0.0000Lungs0.0185Kidneys0.0062Prostate0.0249Sensory organs0.0558STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0068Ovary-uterus0.0091Endocrine tissue0.0000Fetal0.0012Gastrointestinal0.0244Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0082Nerves0.0070Prostate0.0064Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 29NORMALBladder0.00000.01020.0000undefBreast0.00130.01090.12238.1755Ovary0.00300.00520.58431.7114Endocrine tissue0.00360.00820.44652.2395Gastrointestinal0.00580.0000undef0.0000Brain0.00250.03070.082912.0569 Hematopoietic0.01400.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.00500.0000undef0.0000Heart0.00000.0000undefundefTesticles0.00000.02340.0000undefLungs0.00370.0000undef0.0000Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00510.00600.85651.1675Kidneys0.00000.02050.0000undefPancreas0.00380.0000undef0.0000Penis0.00000.0000undefundefProstate0.00710.00431.67790.5960Uterus0.00330.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0062Prostatic hyperplasia0.0059Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0226FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0000Hematopoietic0.0197Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0204Ovary-uterus0.0023Endocrine tissue0.0000Fetal0.0023Gastrointestinal0.0000Hematopoietic0.0114Skin-muscle0.0000Testicles0.0000Lungs0.0164Nerves0.0030Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 30NORMALBladder0.01860.01531.21230.8249Breast0.01330.04360.30583.2702Ovary0.01820.01301.40230.7131Endocrine tissue0.00730.01910.38272.6128Gastrointestinal0.01940.00952.03570.4912Brain0.02370.04490.52871.8916Hematopoietic0.00980.0000undef0.0000Skin0.00990.0000undef0.0000Hepatic0.00500.00650.76511.3069Heart0.02540.05500.46242.1624Testicles0.02440.0000undef0.0000Lungs0.02240.01651.35440.7383Stomach-esophagus0.00000.03070.0000undefMuscle-skeleton0.00860.01800.47582.1015Kidneys0.02080.02051.01300.9871Pancreas0.01140.03870.29393.4030Penis0.01200.02670.44922.2260Prostate0.02140.01281.67790.5960Uterus0.00660.01420.46422.1544Breast hyperplasia0.0073Small intestine0.0031Prostatic hyperplasia0.0059Seminal vesicles0.0000Sensory organs0.0118White blood cells0.0305FETUSDevelopment0.1537Gastrointestinal0.0401Brain0.1126Hematopoietic0.0472Heart-blood vessels0.0164Lungs0.0481Kidneys0.0247Prostate0.0499Sensory organs0.1954STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0544Ovary-uterus0.0320Endocrine tissue0.0000Fetal0.0636Gastrointestinal0.0610Hematopoietic0.0057Skin-muscle0.1328Testicles0.0000Lungs0.0082Nerves0.0191Prostate0.0064Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 31NORMALBladder0.00460.00261.81850.5499Breast0.00270.01090.24464.0878Ovary0.00000.00780.0000undefEndocrine tissue0.00180.00540.33492.9861Gastrointestinal0.00780.00481.62850.6141Brain0.02630.01102.39970.4167Hematopoietic0.00420.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.00990.0000undef0.0000Heart0.00640.02750.23124.3248Testicles0.00000.01170.0000undefLungs0.01120.00472.37020.4219Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00510.00600.85651.1675Kidneys0.00890.0000undef0.0000Pancreas0.00570.0000undef0.0000Penis0.01500.0000undef0.0000Prostate0.00480.00640.74581.3409Uterus0.00000.0000undefundefBreast hyperplasia0.0036Small intestine0.0125Prostatic hyperplasia0.0059Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0044FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0063Hematopoietic0.0079Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0249Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0136Ovary-uterus0.0091Endocrine tissue0.0000Fetal0.0047Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0227Testicles0.0000Lungs0.0246Nerves0.0231Prostate0.0064Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 33NORMALBladder0.01390.02300.60621.6497Breast0.00130.01310.10199.8107Ovary0.00610.00780.77911.2836Endocrine tissue0.01280.00274.68850.2133Gastrointestinal0.01740.00483.66420.2729Brain0.00850.01420.59551.6794Hematopoietic0.00560.0000undef0.0000Skin0.02490.0000undef0.0000Hepatic0.00000.02590.0000undefHeart0.01590.01371.15610.8650Testicles0.00000.0000undefundefLungs0.02240.02600.86191.1602Stomach-esophagus0.00970.0000undef0.0000Muscle-skeleton0.01540.00602.56960.3892Kidneys0.01490.01371.08540.9213Pancreas0.00380.01100.34282.9168Penis0.01200.02670.44922.2260Prostate0.01910.02550.74581.3409Uterus0.01320.00711.85670.5386Breast hyperplasia0.0145Small intestine0.0093Prostatic hyperplasia0.0208Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0183FETUSDevelopment0.0000Gastrointestinal0.0123Brain0.0063Hematopoietic0.0000Heart-blood vessels0.0041Lungs0.0037Kidneys0.0124Prostate0.0748Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0204Ovary-uterus0.0091Endocrine tissue0.0000Fetal0.0070Gastrointestinal0.0366Hematopoietic0.0114Skin-muscle0.0356Testicles0.0000Lungs0.0164Nerves0.0010Prostate0.0128Sensory organs0.0155Electronic Northern for SEQ. ID NO.: 35NORMALBladder0.01390.0000undef0.0000Breast0.00130.01090.12238.1755Ovary0.00910.00781.16860.8557Endocrine tissue0.01280.00821.56280.6399Gastrointestinal0.00970.00951.01780.9825Brain0.00680.00661.03210.9689Hematopoietic0.00280.0000undef0.0000Skin0.00990.0000undef0.0000Hepatic0.02480.0000undef0.0000Heart0.00530.0000undef0.0000Testicles0.00000.0000undefundefLungs0.00370.00950.39502.5314Stomach-esophagus0.00000.01530.0000undefMuscle-skeleton0.00690.00601.14200.8756Kidneys0.01490.00682.17080.4607Pancreas0.00570.00551.02850.9723Penis0.01200.0000undef0.0000Prostate0.00480.00640.74581.3409Uterus0.00170.00710.23214.3088Breast hyperplasia0.0000Small intestine0.0093Prostatic hyperplasia0.0059Seminal vesicles0.0089Sensory organs0.0118White blood cells0.0017FETUSDevelopment0.0154Gastrointestinal0.0062Brain0.0063Hematopoietic0.0000Heart-blood vessels0.0041Lungs0.0074Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0068Ovary-uterus0.0091Endocrine tissue0.0000Fetal0.0111Gastrointestinal0.0122Hematopoietic0.0057Skin-muscle0.0453Testicles0.0078Lungs0.0000Nerves0.0100Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 36NORMALBladder0.00000.00260.0000undefBreast0.00130.01090.12238.1755Ovary0.00000.0000undefundefEndocrine tissue0.00000.00270.0000undefGastrointestinal0.00190.0000undef0.0000Brain0.00510.00114.64460.2153Hematopoietic0.00420.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.00650.0000undefHeart0.00000.0000undefundefTesticles0.00000.0000undefundefLungs0.00000.0000undefundefStomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00340.0000undef0.0000Kidneys0.00000.0000undefundefPancreas0.00000.0000undefundefPenis0.00000.0000undefundefProstate0.00480.00212.23730.4470Uterus0.00000.0000undefundefBreast hyperplasia0.0000Small intestine0.0000Prostatic hyperplasia0.0059Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0026FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0125Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0062Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0114Endocrine tissue0.0000Fetal0.0017Gastrointestinal0.0122Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0020Prostate0.0064Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 37NORMALBladder0.00460.01020.45462.1996Breast0.00000.02180.0000undefOvary0.01220.04420.27503.6368Endocrine tissue0.00000.00270.0000undefGastrointestinal0.01360.01900.71251.4035Brain0.00080.00770.11069.0427Hematopoietic0.03220.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.00000.01290.0000undefHeart0.00210.0000undef0.0000Testicles0.00000.02340.0000undefLungs0.05350.04731.13240.8831Stomach-esophagus0.06760.07670.88191.1339Muscle-skeleton0.00860.0000undef0.0000Kidneys0.00000.00680.0000undefPancreas0.01140.00552.05700.4861Penis0.00300.0000undef0.0000Prostate0.00710.01280.55931.7879Uterus0.00170.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0249Prostatic hyperplasia0.0030Seminal vesicles0.0000Sensory organs0.0235White blood cells0.1140FETUSDevelopment0.0154Gastrointestinal0.0154Brain0.0000Hematopoietic0.0039Heart-blood vessels0.0041Lungs0.0037Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0029Gastrointestinal0.0366Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0082Nerves0.0000Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 38NORMALBladder0.00000.00260.0000undefBreast0.00670.01310.50961.9621Ovary0.00610.0000undef0.0000Endocrine tissue0.00360.0000undef0.0000Gastrointestinal0.00190.0000undef0.0000Brain0.00000.00330.0000undefHematopoietic0.00840.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.0000undefundefHeart0.00210.0000undef0.0000Testicles0.00000.0000undefundefLungs0.00000.0000undefundefStomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00000.0000undefundefKidneys0.01190.0000undef0.0000Pancreas0.00000.0000undefundefPenis0.00000.0000undefundefProstate0.00240.00430.55931.7879Uterus0.00170.0000undef0.0000Breast hyperplasia0.0073Small intestine0.0031Prostatic hyperplasia0.0030Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0026FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0124Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0046Endocrine tissue0.0490Fetal0.0029Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0082Nerves0.0131Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 39NORMALBladder0.00930.00771.21230.8249Breast0.00530.02830.18825.3141Ovary0.01220.01300.93491.0696Endocrine tissue0.03470.03001.15690.8644Gastrointestinal0.01360.0000undef0.0000Brain0.01530.01311.16120.8612Hematopoietic0.00560.0000undef0.0000Skin0.01990.0000undef0.0000Hepatic0.01980.00653.06060.3267Heart0.01270.01370.92491.0812Testicles0.01220.01171.04470.9572Lungs0.02120.01651.27920.7818Stomach-esophagus0.01930.0000undef0.0000Muscle-skeleton0.01200.01800.66621.5011Kidneys0.00300.0000undef0.0000Pancreas0.01330.0000undef0.0000Penis0.00300.05330.056217.8081 Prostate0.01670.00642.61010.3831Uterus0.00660.00710.92831.0772Breast hyperplasia0.0073Small intestine0.0125Prostatic hyperplasia0.0208Seminal vesicles0.0000Sensory organs0.0353White blood cells0.0235FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0000Hematopoietic0.0079Heart-blood vessels0.0041Lungs0.0111Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0068Ovary-uterus0.0274Endocrine tissue0.0000Fetal0.0204Gastrointestinal0.0244Hematopoietic0.0000Skin-muscle0.0421Testicles0.0000Lungs0.0164Nerves0.0151Prostate0.0256Sensory organs0.0542Electronic Northern for SEQ. ID NO.: 40NORMALBladder0.00000.0000undefundefBreast0.00270.01740.15296.5404Ovary0.00000.0000undefundefEndocrine tissue0.00000.00820.0000undefGastrointestinal0.00000.00480.0000undefBrain0.00760.0000undef0.0000Hematopoietic0.00280.0000undef0.0000Skin0.01490.0000undef0.0000Hepatic0.00500.0000undef0.0000Heart0.00210.0000undef0.0000Testicles0.00610.0000undef0.0000Lungs0.00870.0000undef0.0000Stomach-esophagus0.00970.0000undef0.0000Muscle-skeleton0.00510.0000undef0.0000Kidneys0.00000.0000undefundefPancreas0.00000.0000undefundefPenis0.00600.0000undef0.0000Prostate0.00240.00211.11860.8939Uterus0.00170.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0031Prostatic hyperplasia0.0030Seminal vesicles0.0178Sensory organs0.0000White blood cells0.0070FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0245Fetal0.0117Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0082Nerves0.0070Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 41NORMALBladder0.00000.01280.0000undefBreast0.00400.02180.18355.4504Ovary0.00000.00260.0000undefEndocrine tissue0.00180.0000undef0.0000Gastrointestinal0.00580.00950.61071.6375Brain0.00000.00330.0000undefHematopoietic0.00560.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.0000undefundefHeart0.00320.0000undef0.0000Testicles0.00000.0000undefundefLungs0.00120.00470.26343.7971Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00340.0000undef0.0000Kidneys0.00000.0000undefundefPancreas0.00000.00550.0000undefPenis0.00300.0000undef0.0000Prostate0.00480.00212.23730.4470Uterus0.00500.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0031Prostatic hyperplasia0.0000Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0061FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0185Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0006Gastrointestinal0.0000Hematopoietic0.0228Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0000Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 42NORMALBladder0.00000.00510.0000undefBreast0.00530.01090.48932.0439Ovary0.00300.00520.58431.7114Endocrine tissue0.00000.00270.0000undefGastrointestinal0.00000.0000undefundefBrain0.00000.0000undefundefHematopoietic0.00000.0000undefundefSkin0.00000.0000undefundefHepatic0.00500.0000undef0.0000Heart0.00000.0000undefundefTesticles0.00000.0000undefundefLungs0.00500.00242.10690.4746Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00000.0000undefundefKidneys0.00000.0000undefundefPancreas0.00000.0000undefunuefPenis0.00000.0000undefundefProstate0.00480.0000undef0.0000Uterus0.00000.0000undefundefBreast hyperplasia0.0036Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0000Sensory organs0.0235White blood cells0.0000FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0340Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0146Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0130Testicles0.0000Lungs0.0082Nerves0.0181Prostate0.0000Sensory organs0.0077Electronic Northern for SEQ. ID NO.: 43NORMALBladder0.00000.00260.0000undefBreast0.00130.01090.12238.1755Ovary0.00300.0000undef0.0000Endocrine tissue0.00180.0000undef0.0000Gastrointestinal0.00000.0000undefundefBrain0.00080.0000undef0.0000Hematopoietic0.00000.0000undefundefSkin0.00000.0000undefundefHepatic0.00000.0000undefundefHeart0.00000.0000undefundefTesticles0.00000.0000undefundefLungs0.00000.00240.0000undefStomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00000.0000undefundefKidneys0.00300.0000undef0.0000Pancreas0.00000.0000undefundefPenis0.00000.02670.0000undefProstate0.00000.0000undefundefUterus0.00170.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0000Sensory organs0.0118White blood cells0.0000FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0029Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0010Prostate0.0064Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 44NORMALBladder0.00000.0000undefundefBreast0.00130.01530.087411.4458 Ovary0.00000.00520.0000undefEndocrine tissue0.00000.0000undefundefGastrointestinal0.00000.00480.0000undefBrain0.00000.0000undefunaefHematopoietic0.00000.0000undefundefSkin0.00000.0000undefundefHepatic0.00000.0000undefundefHeart0.00000.0000undefundefTesticles0.00000.0000undefundefLungs0.00120.0000undef0.0000Stomach-esophagus0.01930.0000undef0.0000Muscle-skeleton0.00000.0000undefundefKidneys0.00000.0000undefundefPancreas0.00000.0000undefundefPenis0.00600.0000undef0.0000Prostate0.00000.0000undefundefUterus0.00000.0000undefundefBreast hyperplasia0.0000Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0000FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0039Heart-blood vessels0.0041Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0023Endocrine tissue0.0000Fetal0.0000Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0010Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 45NORMALBladder0.01390.0000undef0.0000Breast0.00930.01960.47572.1023Ovary0.01220.00781.55820.6418Endocrine tissue0.00360.00540.66981.4930Gastrointestinal0.00970.0000undef0.0000Brain0.01100.01310.83861.1924Hematopoietic0.00280.03780.073913.5274 Skin0.03480.0000undef0.0000Hepatic0.00990.0000undef0.0000Heart0.01060.0000undef0.0000Testicles0.00610.01170.52241.9144Lungs0.01120.00951.18510.8438Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00510.00600.85651.1675Kidneys0.00890.00681.30250.7678Pancreas0.01330.00552.39990.4167Penis0.00900.0000undef0.0000Prostate0.00950.00432.23730.4470Uterus0.00660.00710.92831.0772Breast hperplasia0.0109Small intestine0.0062Prostatic hyperplasia0.0030Seminal vesicles0.0089Sensory organs0.0235White blood cells0.0078FETUSDevelopment0.0154Gastrointestinal0.0092Brain0.0125Hematopoietic0.0000Heart-blood vessels0.0082Lungs0.0296Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0046Endocrine tissue0.0000Fetal0.0210Gastrointestinal0.0122Hematopoietic0.0114Skin-muscle0.0032Testicles0.0000Lungs0.0164Nerves0.0131Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 46NORMALBladder0.02320.00514.54620.2200Breast0.00270.01530.17475.7229Ovary0.00300.00780.38952.5671Endocrine tissue0.00000.00540.0000undefGastrointestinal0.00190.00950.20364.9124Brain0.00760.00990.77411.2918Hematopoietic0.00280.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00500.00650.76511.3069Heart0.00530.05500.096310.3795 Testicles0.01220.01171.04470.9572Lungs0.00370.00710.52671.8986Stomach-esophagus0.02900.00773.77980.2646Muscle-skeleton0.00170.0000undef0.0000Kidneys0.00890.00681.30250.7678Pancreas0.00760.00551.37130.7292Penis0.00300.0000undef0.0000Prostate0.00240.01060.22374.4697Uterus0.00830.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0062Prostatic hyperplasia0.0089Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0017FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0063Hematopoietic0.0000Heart-blood vessels0.0041Lungs0.0074Kidneys0.0247Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0068Endocrine tissue0.0000Fetal0.0017Gastrointestinal0.0122Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0082Nerves0.0020Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 47NORMALBladder0.00000.00510.0000undefBreast0.00130.01310.10199.8107Ovary0.00300.00520.58431.7114Endocrine tissue0.00550.0000undef0.0000Gastrointestinal0.00000.0000undefundefBrain0.00680.00551.23860.8074Hematopoietic0.00420.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00990.0000undef0.0000Heart0.00320.0000undef0.0000Testicles0.00000.0000undefundefLungs0.00000.00470.0000undefStomach-esophagus0.00000.01530.0000undefMuscle-skeleton0.00340.0000undef0.0000Kidneys0.00890.00681.30250.7678Pancreas0.00000.0000undefundefPenis0.00300.0000undef0.0000Prostate0.00000.00850.0000undefUterus0.00330.0000undef0.0000Breast hyperplasia0.0073Small intestine0.0062Prostatic hyperplasia0.0059Seminal vesicles0.0178Sensory organs0.0000White blood cells0.0009FETUSDevelopment0.0154Gastrointestinal0.0031Brain0.0063Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0062Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0023Endocrine tissue0.0000Fetal0.0023Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0065Testicles0.0000Lungs0.0082Nerves0.0000Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 48NORMALBladder0.00930.00511.81850.5499Breast0.00530.01960.27183.6790Ovary0.00610.00521.16860.8557Endocrine tissue0.00730.01090.66981.4930Gastrointestinal0.00970.01430.67861.4737Brain0.00590.00222.70940.3691Hematopoietic0.00420.03780.11099.0183Skin0.00500.0000undef0.0000Hepatic0.00000.00650.0000undefHeart0.01380.0000undef0.0000Testicles0.01220.02340.52241.9144Lungs0.00120.00710.17565.6957Stomach-esophagus0.02900.0000undef0.0000Muscle-skeleton0.00510.01200.42832.3350Kidneys0.00000.0000undefundefPancreas0.00950.0000undef0.0000Penis0.01500.0000undef0.0000Prostate0.00480.00850.55931.7879Uterus0.00500.00710.69631.4363Breast hyperplasia0.0000Small intestine0.0093Prostatic hyperplasia0.0089Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0044FETUSDevelopment0.0307Gastrointestinal0.0062Brain0.0063Hematopoietic0.0118Heart-blood vessels0.0164Lungs0.0148Kidneys0.0062Prostate0.0499Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0137Endocrine tissue0.0000Fetal0.0187Gastrointestinal0.0244Hematopoietic0.0000Skin-muscle0.0194Testicles0.0156Lungs0.0000Nerves0.0131Prostate0.0321Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 49NORMALBladder0.00000.00770.0000undefBreast0.00400.01530.26213.8153Ovary0.00910.02860.31873.1376Endocrine tissue0.01820.03270.55821.7916Gastrointestinal0.01550.00951.62850.6141Brain0.01270.00991.29020.7751Hematopoietic0.00980.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00990.0000undef0.0000Heart0.02650.02750.96341.0380Testicles0.00610.01170.52241.9144Lungs0.01490.02600.57461.7403Stomach-esophagus0.00970.00771.25990.7937Muscle-skeleton0.01030.00601.71300.5838Kidneys0.02080.03420.60781.6452Pancreas0.00190.00550.34282.9168Penis0.00600.0000undef0.0000Prostate0.00240.01060.22374.4697Uterus0.00990.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0093Prostatic hyperplasia0.0059Seminal vesicles0.0178Sensory organs0.0118White blood cells0.0052FETUSDevelopment0.0000Gastrointestinal0.0062Brain0.0125Hematopoietic0.0236Heart-blood vessels0.0286Lungs0.0074Kidneys0.0062Prostate0.0000Sensory organs0.0279STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0114Endocrine tissue0.0000Fetal0.0210Gastrointestinal0.0244Hematopoietic0.0000Skin-muscle0.0421Testicles0.0000Lungs0.0164Nerves0.0050Prostate0.0064Sensory organs0.0155Electronic Northern for SEQ. ID NO.: 50NORMALBladder0.00000.01790.0000undefBreast0.00130.00650.20394.9053Ovary0.00000.0000undefundefEndocrine tissue0.00180.0000undef0.0000Gastrointestinal0.00190.0000undef0.0000Brain0.00080.00220.38712.5836Hematopoietic0.00140.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00500.0000undef0.0000Heart0.00320.0000undef0.0000Testicles0.00000.0000undefundefLungs0.00120.00470.26343.7971Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00170.00600.28553.5025Kidneys0.00000.0000undefundefPancreas0.00000.00550.0000undefPenis0.00000.0000undefundefProstate0.00000.0000undefundefUterus0.00830.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0009FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0046Endocrine tissue0.0000Fetal0.0064Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0065Testicles0.0000Lungs0.0164Nerves0.0040Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 51NORMALBladder0.00000.00510.0000undefBreast0.00530.01530.34952.8614Ovary0.02130.02340.90891.1002Endocrine tissue0.01820.05180.35252.8368Gastrointestinal0.00780.00481.62850.6141Brain0.01360.01201.12600.8881Hematopoietic0.00980.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.01940.0000undefHeart0.00950.0000undef0.0000Testicles0.04280.01173.65650.2735Lungs0.01370.01420.96561.0356Stomach-esophagus0.00970.0000undef0.0000Muscle-skeleton0.00170.06000.028635.0255 Kidneys0.01780.04790.37212.6872Pancreas0.01700.0000undef0.0000Penis0.01500.0000undef0.0000Prostate0.00710.03830.18645.3637Uterus0.00660.00710.92831.0772Breast hyperplasia0.0218Small intestine0.0000Prostatic hyperplasia0.0208Seminal vesicles0.0089Sensory organs0.0353White blood cells0.0218FETUSDevelopment0.0154Gastrointestinal0.0123Brain0.0000Hematopoietic0.0039Heart-blood vessels0.0164Lungs0.0037Kidneys0.0185Prostate0.0249Sensory organs0.0140STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0434Endocrine tissue0.0000Fetal0.0210Gastrointestinal0.0366Hematopoietic0.0000Skin-muscle0.0972Testicles0.0468Lungs0.0082Nerves0.0151Prostate0.0321Sensory organs0.0310Electronic Northern for SEQ. ID NO.: 52NORMALBladder0.02320.02560.90921.0998Breast0.00530.01310.40772.4527Ovary0.00610.00780.77911.2836Endocrine tissue0.01090.00542.00930.4977Gastrointestinal0.00970.0000undef0.0000Brain0.00420.01310.32253.1004Hematopoietic0.00980.0000undef0.0000Skin0.02490.0000undef0.0000Hepatic0.00000.0000undefundefHeart0.02010.0000undef0.0000Testicles0.00000.01170.0000undefLungs0.01250.01181.05340.9493Stomach-esophagus0.03860.01532.51980.3968Muscle-skeleton0.00340.00600.57101.7513Kidneys0.01190.01370.86831.1517Pancreas0.00380.01100.34282.9168Penis0.00900.05330.16855.9360Prostate0.01190.01700.69911.4303Uterus0.00990.01420.69631.4363Breast hyperplasia0.0073Small intestine0.0125Prostatic hyperplasia0.0119Seminal vesicles0.0178Sensory organs0.0000White blood cells0.0052FETUSDevelopment0.0307Gastrointestinal0.0062Brain0.0063Hematopoietic0.0236Heart-blood vessels0.0041Lungs0.0037Kidneys0.0000Prostate0.0748Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0205Endocrine tissue0.0000Fetal0.0128Gastrointestinal0.0244Hematopoietic0.0057Skin-muscle0.0130Testicles0.0078Lungs0.0000Nerves0.0030Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 53NORMALBladder0.00930.00511.81850.5499Breast0.00530.01530.34952.8614Ovary0.00000.00260.0000undefEndocrine tissue0.00180.0000undef0.0000Gastrointestinal0.00390.01430.27143.6843Brain0.00340.01640.20644.8443Hematopoietic0.00280.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.00000.01940.0000undefHeart0.00320.0000undef0.0000Testicles0.00610.0000undef0.0000Lungs0.00750.00471.58010.6329Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00340.01800.19035.2538Kidneys0.00590.01370.43422.3033Pancreas0.00190.00550.34282.9168Penis0.00600.0000undef0.0000Prostate0.00240.00430.55931.7879Uterus0.00660.0000undef0.0000Breast hyperplasia0.0073Small intestine0.0093Prostatic hyperplasia0.0030Seminal vesicles0.0000Sensory organs0.0118White blood cells0.0000FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0000Hematopoietic0.0079Heart-blood vessels0.0000Lungs0.0000Kidneys0.0062Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0046Endocrine tissue0.0000Fetal0.0006Gastrointestinal0.0000Hematopoietic0.0057Skin-muscle0.0097Testicles0.0000Lungs0.0082Nerves0.0050Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 54NORMALBladder0.01390.01021.36390.7332Breast0.00800.02180.36692.7252Ovary0.01220.01820.66781.4975Endocrine tissue0.01280.01910.66981.4930Gastrointestinal0.00970.02860.33932.9474Brain0.00590.01100.54191.8454Hematopoietic0.02800.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.00000.01290.0000undefHeart0.01270.0000undef0.0000Testicles0.01220.01171.04470.9572Lungs0.01000.00711.40460.7120Stomach-esophagus0.00000.01530.0000undefMuscle-skeleton0.02230.0000undef0.0000Kidneys0.01490.01371.08540.9213Pancreas0.01330.04420.30003.3335Penis0.00600.0000undef0.0000Prostate0.00950.01280.74581.3409Uterus0.02640.0000undef0.0000Breast hyperplasia0.0036Small intestine0.0125Prostatic hyperplasia0.0238Seminal vesicles0.0267Sensory organs0.0118White blood cells0.0026FETUSDevelopment0.0000Gastrointestinal0.0123Brain0.0125Hematopoietic0.0118Heart-blood vessels0.0000Lungs0.0111Kidneys0.0309Prostate0.0249Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0136Ovary-uterus0.0274Endocrine tissue0.0245Fetal0.0099Gastrointestinal0.0122Hematopoietic0.0228Skin-muscle0.0324Testicles0.0000Lungs0.0082Nerves0.0131Prostate0.0000Sensory organs0.0077Electronic Northern for SEQ. ID NO.: 55NORMALBladder0.00460.00510.90921.0998Breast0.00670.01530.43682.2892Ovary0.00000.01300.0000undefEndocrine tissue0.00910.01360.66981.4930Gastrointestinal0.01360.01430.95001.0527Brain0.01440.00881.64500.6079Hematopoietic0.00700.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00990.0000undef0.0000Heart0.00420.01370.30833.2436Testicles0.00000.01170.0000undefLungs0.00620.00950.65841.5189Stomach-esophagus0.00000.09970.0000undefMuscle-skeleton0.00170.01800.095210.5076 Kidneys0.01190.01370.86831.1517Pancreas0.00950.01100.85711.1667Penis0.01500.0000undef0.0000Prostate0.00710.01280.55931.7879Uterus0.00990.00711.39250.7181Breast hyperplasia0.0036Small intestine0.0218Prostatic hyperplasia0.0089Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0070FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0000Hematopoietic0.0157Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0068Ovary-uterus0.0068Endocrine tissue0.0000Fetal0.0029Gastrointestinal0.0366Hematopoietic0.0171Skin-muscle0.0032Testicles0.0078Lungs0.0082Nerves0.0080Prostate0.0064Sensory organs0.0077Electronic Northern for SEQ. ID NO.: 56NORMALBladder0.00000.02040.0000undefBreast0.00000.02180.0000undefOvary0.00000.00260.0000undefEndocrine tissue0.00000.00540.0000undefGastrointestinal0.00390.00480.81431.2281Brain0.00080.00110.77411.2918Hematopoietic0.00000.0000undefundefSkin0.00000.0000undefundefHepatic0.00000.0000undefundefHeart0.00000.0000undefundefTesticles0.00000.0000undefundefLungs0.00120.00470.26343.7971Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00000.0000undefundefKidneys0.00000.0000undefundefPancreas0.00000.01100.0000undefPenis0.00000.02670.0000undefProstate0.00000.0000undefundefUterus0.00330.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0009FETUSDevelopment0.0000Gastrointestinal0.0062Brain0.0000Hematopoietic0.0079Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0136Ovary-uterus0.0320Endocrine tissue0.0000Fetal0.0367Gastrointestinal0.0000Hematopoietic0.0114Skin-muscle0.0065Testicles0.0000Lungs0.0164Nerves0.0000Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 57NORMALBladder0.00460.00510.90921.0998Breast0.00270.01090.24464.0878Ovary0.00910.00263.50590.2852Endocrine tissue0.00360.00540.66981.4930Gastrointestinal0.00190.0000undef0.0000Brain0.00170.00440.38712.5836Hematopoietic0.00280.0000undef0.0000Skin0.00000.08470.0000undefHepatic0.00000.0000undefundefHeart0.00210.0000undef0.0000Testicles0.00000.0000undefundefLungs0.00500.0000undef0.0000Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00170.00600.28553.5025Kidneys0.00000.0000undefundefPancreas0.00570.01100.51431.9446Penis0.00000.0000undefundefProstate0.00000.00210.0000undefUterus0.00330.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0031Prostatic hyperplasia0.0059Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0061FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0000Hematopoietic0.0079Heart-blood vessels0.0000Lungs0.0074Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0000Gastrointestinal0.0122Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0050Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 58NORMALBladder0.00000.0000undefundefBreast0.01730.05230.33133.0187Ovary0.00000.00260.0000undefEndocrine tissue0.00180.0000undef0.0000Gastrointestinal0.00000.0000undefundefBrain0.00000.0000undefundefHematopoietic0.00280.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.00000.0000undefundefHeart0.00000.0000undefundefTesticles0.00000.0000undefundefLungs0.00000.0000undefundefStomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00000.0000undefundefKidneys0.00000.0000undefundefPancreas0.00000.0000undefundefPenis0.00000.0000undefundefProstate0.00240.0000undef0.0000Uterus0.00660.02850.23214.3088Breast hyperplasia0.0073Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0000FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0000Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0000Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 59NORMALBladder0.00460.00510.90921.0998Breast0.00130.01090.12238.1755Ovary0.00610.0000undef0.0000Endocrine tissue0.00180.0000undef0.0000Gastrointestinal0.00390.00950.40712.4562Brain0.00250.00660.38712.5836Hematopoietic0.00000.0000undefundefSkin0.00000.0000undefundefHepatic0.00000.00650.0000undefHeart0.00740.0000undef0.0000Testicles0.00610.02340.26123.8288Lungs0.00250.00950.26343.7971Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00170.0000undef0.0000Kidneys0.00300.00680.43422.3033Pancreas0.00000.00550.0000undefPenis0.00600.0000undef0.0000Prostate0.00240.0000undef0.0000Uterus0.00170.0000undef0.0000Breast hyperplasia0.0073Small intestine0.0031Prostatic hyperplasia0.0089Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0009FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0082Lungs0.0037Kidneys0.0185Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0068Ovary-uterus0.0160Endocrine tissue0.0245Fetal0.0035Gastrointestinal0.0000Hematopoietic0.0114Skin-muscle0.0000Testicles0.0000Lungs0.0000Nerves0.0020Prostate0.0064Sensory organs0.0155Electronic Northern for SEQ. ID NO.: 61NORMALBladder0.00000.0000undefundefBreast0.00130.01090.12238.1755Ovary0.00000.0000undefundefEndocrine tissue0.00910.02450.37212.6874Gastrointestinal0.00000.0000undefundefBrain0.00170.00220.77411.2918Hematopoietic0.00140.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.0000undefundefHeart0.00320.0000undef0.0000Testicles0.00610.0000undef0.0000Lungs0.00500.00242.10690.4746Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00340.0000undef0.0000Kidneys0.00300.0000undef0.0000Pancreas0.00000.00550.0000undefPenis0.00300.0000undef0.0000Prostate0.00240.00850.27973.5758Uterus0.00000.0000undefundefBreast hyperplasia0.0000Small intestine0.0031Prostatic hyperplasia0.0059Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0000FETUSDevelopment0.0000Gastrointestinal0.0031Brain0.0000Hematopoietic0.0157Heart-blood vessels0.0041Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0068Endocrine tissue0.0000Fetal0.0128Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0162Testicles0.0000Lungs0.0082Nerves0.0020Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 62NORMALBladder0.00000.00510.0000undefBreast0.00800.01530.52421.9076Ovary0.00910.00781.16860.8557Endocrine tissue0.00550.01090.50231.9907Gastrointestinal0.00780.02380.32573.0703Brain0.00510.00770.66351.5071Hematopoietic0.01400.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00990.0000undef0.0000Heart0.00000.0000undefundefTesticles0.00610.0000undef0.0000Lungs0.00500.00471.05340.9493Stomach-esophagus0.00000.00770.0000undefMuscle-skeleton0.00170.0000undef0.0000Kidneys0.00590.00680.86831.1517Pancreas0.00190.0000undef0.0000Penis0.00300.0000undef0.0000Prostate0.00480.00212.23730.4470Uterus0.00330.02140.15476.4632Breast hyperplasia0.0000Small intestine0.0031Prostatic hyperplasia0.0119Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0035FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0063Hematopoietic0.0079Heart-blood vessels0.0041Lungs0.0074Kidneys0.0185Prostate0.0000Sensory organs0.0140STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0091Endocrine tissue0.0000Fetal0.0087Gastrointestinal0.0244Hematopoietic0.0057Skin-muscle0.0097Testicles0.0156Lungs0.0000Nerves0.0030Prostate0.0000Sensory organs0.0697Electronic Northern for SEQ. ID NO.: 63NORMALBladder0.00460.0000undef0.0000Breast0.00000.01090.0000undefOvary0.00300.00261.16860.8557Endocrine tissue0.00180.00270.66981.4930Gastrointestinal0.00390.0000undef0.0000Brain0.00340.00440.77411.2918Hematopoietic0.00420.0000undef0.0000Skin0.00000.0000undefundefHepatic0.01490.0000undef0.0000Heart0.00110.0000undef0.0000Testicles0.00000.0000undefundefLungs0.00120.0000undef0.0000Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00170.00600.28553.5025Kidneys0.00590.0000undef0.0000Pancreas0.00190.00550.34282.9168Penis0.00600.0000undef0.0000Prostate0.00000.0000undefundefUterus0.00330.0000undef0.0000Breast hyperplasia0.0036Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0089Sensory organs0.0000White blood cells0.0026FETUSDevelopment0.0000Gastrointestinal0.0092Brain0.0125Hematopoietic0.0039Heart-blood vessels0.0082Lungs0.0000Kidneys0.0062Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0046Endocrine tissue0.0490Fetal0.0058Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0065Testicles0.0000Lungs0.0000Nerves0.0010Prostate0.0000Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 64NORMALBladder0.00460.06650.069914.2976Breast0.00800.04360.18355.4504Ovary0.00610.02340.25973.8507Endocrine tissue0.00000.0000undefundefGastrointestinal0.02130.05710.37322.6795Brain0.00080.0000undef0.0000Hematopoietic0.00280.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.01940.0000undefHeart0.00000.0000undefundefTesticles0.00000.0000undefundefLungs0.00870.01420.61451.6273Stomach-esophagus0.02900.0000undef0.0000Muscle-skeleton0.00000.0000undefundefKidneys0.01190.02050.57891.7275Pancreas0.01330.02760.48002.0835Penis0.00000.0000undefundefProstate0.01190.01061.11860.8939Uterus0.00330.00710.46422.1544Breast hyperplasia0.0073Small intestine0.0343Prostatic hyperplasia0.0208Seminal vesicles0.0178Sensory organs0.0353White blood cells0.0000FETUSDevelopment0.0000Gastrointestinal0.0092Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0037Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0476Ovary-uterus0.0274Endocrine tissue0.0000Fetal0.0052Gastrointestinal0.0122Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0082Nerves0.0000Prostate0.0064Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 65NORMALBladder0.00000.00510.0000undefBreast0.00530.01740.30583.2702Ovary0.00610.00262.33720.4279Endocrine tissue0.00730.00272.67910.3733Gastrointestinal0.00970.00482.03570.4912Brain0.00590.00551.08370.9227Hematopoietic0.00420.0000undef0.0000Skin0.00500.0000undef0.0000Hepatic0.00000.0000undefundefHeart0.00530.0000undef0.0000Testicles0.00000.0000undefundefLungs0.00870.00711.22900.8137Stomach-esophagus0.00000.01530.0000undefMuscle-skeleton0.01030.0000undef0.0000Kidneys0.00000.00680.0000undefPancreas0.00380.00550.68571.4584Penis0.01200.02670.44922.2260Prostate0.00000.00210.0000undefUterus0.00990.01420.69631.4363Breast hyperplasia0.0000Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0087FETUSDevelopment0.0000Gastrointestinal0.0154Brain0.0000Hematopoietic0.0039Heart-blood vessels0.0041Lungs0.0000Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0136Ovary-uterus0.0046Endocrine tissue0.0000Fetal0.0082Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0032Testicles0.0156Lungs0.0082Nerves0.0040Prostate0.0128Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 66NORMALBladder0.00930.15080.061616.2223 Breast0.00130.03920.034029.4320 Ovary0.01520.0000undef0.0000Endocrine tissue0.00180.00270.66981.4930Gastrointestinal0.01740.00483.66420.2729Brain0.00510.00550.92891.0765Hematopoietic0.09930.0000undef0.0000Skin0.02490.0000undef0.0000Hepatic0.00000.01290.0000undefHeart0.00530.0000undef0.0000Testicles0.00610.0000undef0.0000Lungs0.02610.03070.85081.1753Stomach-esophagus0.10620.02304.61970.2165Muscle-skeleton0.01710.01800.95171.0508Kidneys0.00000.00680.0000undefPancreas0.01140.0000undef0.0000Penis0.12580.16000.78621.2720Prostate0.00000.0000undefundefUterus0.08260.0000undef0.0000Breast hyperplasia0.0036Small intestine0.0000Prostatic hyperplasia0.0000Seminal vesicles0.0178Sensory organs0.0000White blood cells0.1018FETUSDevelopment0.0000Gastrointestinal0.0062Brain0.0000Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0037Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0052Gastrointestinal0.0122Hematopoietic0.0057Skin-muscle0.0000Testicles0.0000Lungs0.0410Nerves0.0000Prostate0.0449Sensory organs0.0000Electronic Northern for SEQ. ID NO.: 67NORMALBladder0.00930.00511.81850.5499Breast0.00130.00440.30583.2702Ovary0.00000.00520.0000undefEndocrine tissue0.00730.01090.66981.4930Gastrointestinal0.00000.0000undefundefBrain0.00680.00551.23860.8074Hematopoietic0.00280.0000undef0.0000Skin0.00000.0000undefundefHepatic0.00000.01290.0000undefHeart0.00420.0000undef0.0000Testicles0.00000.02340.0000undefLungs0.00250.0000undef0.0000Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00000.0000undefundefKidneys0.00000.00680.0000undefPancreas0.00570.0000undef0.0000Penis0.00300.0000undef0.0000Prostate0.07860.05541.41980.7043Uterus0.00330.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0000Prostatic hyperplasia0.1011Seminal vesicles0.0000Sensory organs0.0000White blood cells0.0017FETUSDevelopment0.0000Gastrointestinal0.0062Brain0.0000Hematopoietic0.0039Heart-blood vessels0.0000Lungs0.0037Kidneys0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0082Gastrointestinal0.0000Hematopoietic0.0057Skin-muscle0.0065Testicles0.0078Lungs0.0082Nerves0.0030Prostate0.0128Sensory organs0.0000Electronic Northern for Seq. ID: 149NORMALB lymphoma0.00500.01360.36792.7181Bladder0.00780.02580.30173.3143Breast0.01140.02250.50881.9654Large intestine0.01150.00851.34560.7432Small intestine0.01920.01071.80360.5545Ovary0.00890.00950.93331.0715Endocrine tissue0.02090.03370.61951.6143Brain0.02030.01701.19470.8371Skin0.03670.0000undef0.0000Hepatic0.01860.02540.73241.3653Heart0.01830.01371.32910.7524Testicles0.02410.0000undef0.0000Lung0.01460.01660.87701.1402Stomach-esophagus0.02900.01282.26710.4411Muscle-skeleton0.00690.00740.92781.0778Kidney0.01570.00483.24970.3077Pancreas0.00500.02210.22444.4570Prostate0.02170.01691.28010.7812T lymphoma0.00760.0000undef0.0000Uterus0.01630.02300.70681.4148White blood cells0.02670.0000undef0.0000Hematopoietic0.0080Penis0.0161Seminal vesicle0.0281Sensory organs0.0118FETUSDevelopment0.0000Gastrointestinal0.0111Brain0.0063Hematopoietic0.0000Skin0.0000Hepatic0.0000Heart-blood vessels0.0107Lung0.0108Adrenal gland0.0000Kidney0.0124Placenta0.0303Prostate0.0499Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0253Endocrine tissue0.0000Fetal0.0070Gastrointestinal0.0366Hematopoietic0.0000Skin-muscle0.0227Testicles_n0.0042Testicles_t0.0000Lungs_n0.0000Lungs_t0.0000Nerves0.0090Kidney_t0.0000Ovary_uterus0.0203Prostate_n0.0121Sensory organs0.0000White blood cells0.0000Electronic Northern for Seq. ID: 150NORMALB lymphoma0.00500.0000undef0.0000Bladder0.00780.01170.66381.5065Breast0.00880.01550.56931.7566Large intestine0.02110.00287.40060.1351Small intestine0.00270.0000undef0.0000Ovary0.01190.00244.97730.2009Endocrine tissue0.00320.01420.22634.4181Brain0.00350.0000undef0.0000Skin0.02570.0000undef0.0000Hepatic0.02790.0000undef0.0000Heart0.00710.01370.51691.9347Testicles0.00400.0000undef0.0000Lung0.02920.01481.97330.5068Stomach-esophagus0.00000.00640.0000undefMuscle-skeleton0.00170.0000undef0.0000Kidney0.02690.0000undef0.0000Pancreas0.01650.0000undef0.0000Prostate0.01410.00522.71320.3686T lymphoma0.00000.0000undefundefUterus0.00440.0000undef0.0000White blood cells0.00000.0000undefundefHematopoietic0.0040Penis0.0000Seminal vesicle0.0070Sensory organs0.0000FETUSDevelopment0.0000Gastrointestinal0.0056Brain0.0000Hematopoietic0.0039Skin0.0000Hepatic0.0000Heart-blood vessel0.0036Lung0.0145Adrenal gland0.0254Kidney0.0000Placenta0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0000Endocrine tissue0.0000Fetal0.0058Gastrointestinal0.0244Hematopoietic0.0000Skin-muscle0.0130Testicles_n0.0000Testicles_t0.0000Lungs_n0.0293Lungs_t0.0000Nerves0.0020Kidney_t0.0000Ovary_uterus0.0068Prostate_n0.0243Sensory organs0.0000White blood cells0.0000Electronic Northern for Seq. ID: 151NORMALB lymphoma0.00500.0000undef0.0000Bladder0.00000.00700.0000undefBreast0.00700.00980.71571.3973Large intestine0.00380.00281.34560.7432Small intestine0.00820.01070.77301.2937Ovary0.00300.01190.24894.0182Endocrine tissue0.00480.00710.67901.4727Brain0.01040.01200.87041.1489Skin0.00370.0000undef0.0000Hepatic0.00460.00630.73241.3653Heart0.00100.01370.073813.5431 Testicles0.00000.01180.0000undefLung0.00100.00550.17545.7011Stomach-esophagus0.00000.00640.0000undefMuscle-skeleton0.00860.01480.57991.7246Kidney0.01120.01930.58031.7232Pancreas0.00170.00550.29923.3427Prostate0.00570.01170.48232.0732T lymphoma0.00000.01490.0000undefUterus0.00150.00920.16066.2251White blood cells0.00270.0000undef0.0000Hematopoietic0.0080Penis0.0027Seminal vesicle0.0070Sensory organs0.0235FETUSDevelopment0.0000Gastrointestinal0.0028Brain0.0000Hematopoietic0.0039Skin0.0000Hepatic0.0000Heart-blood vessels0.0000Lung0.0145Adrenal gland0.0000Kidney0.0000Placenta0.0061Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0101Endocrine tissue0.0000Fetal0.0006Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0000Testicles_n0.0125Testicles_t0.0000Lungs_n0.0195Lungs_t0.0000Nerves0.0100Kidney_t0.0000Ovary_uterus0.0068Prostate_n0.0121Sensory organs0.0000White blood cells0.0000Electronic Northern for Seq. ID: 152NORMALB lymphoma0.02500.01361.83950.5436Bladder0.00780.00701.10630.9039Breast0.00970.02110.45922.1776Large intestine0.01920.00573.36390.2973Small intestine0.00550.02130.25773.8812Ovary0.01780.01431.24430.8036Endocrine tissue0.00480.01770.27163.6818Brain0.01910.02690.70921.4100Skin0.00730.0000undef0.0000Hepatic0.00460.00630.73241.3653Heart0.02330.02750.84911.1777Testicles0.01610.0000undef0.0000Lung0.01560.01291.20280.8314Stomach-esophagus0.00000.01920.0000undefMuscle-skeleton0.00860.00741.15970.8623Kidney0.00900.00960.92851.0770Pancreas0.00830.03870.21374.6798Prostate0.00570.00910.62021.6125T lymphoma0.00760.0000undef0.0000Uterus0.00440.0000undef0.0000White blood cells0.02460.0000undef0.0000Hematopoietic0.0094Penis0.0107Seminal vesicle0.0000Sensory organs0.0118FETUSDevelopment0.1253Gastrointestinal0.0305Brain0.0938Hematopoietic0.0275Skin0.0000Hepatic0.0000Heart-blood vessels0.0142Lung0.0325Adrenal gland0.0254Kidney0.0185Placenta0.0242Prostate0.0249Sensory organs0.1255STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0816Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0354Endocrine tissue0.0000Fetal0.0741Gastrointestinal0.0366Hematopoietic0.0000Skin-muscle0.1458Testicles_n0.0000Testicles_t0.0000Lungs_n0.0098Lungs_t0.0000Nerves0.0191Kidney_t0.0000Ovary_uterus0.0248Prostate_n0.0000Sensory organs0.0155White blood cells0.0000Electronic Northern for Seq. ID: 153NORMALB lymphoma0.00000.0000undefundefBladder0.00000.0000undefundefBreast0.00260.01410.18795.3230Large intestine0.00000.00570.0000undefSmall intestine0.00000.0000undefundefOvary0.00000.00480.0000undefEndocrine tissue0.00000.0000undefundefBrain0.00000.00100.0000undefSkin0.00000.0000undefundefHepatic0.00000.00630.0000undefHeart0.00100.0000undef0.0000Testicles0.00000.0000undefundefLung0.00390.00182.10490.4751Stomach-esophagus0.01450.0000undef0.0000Muscle-skeleton0.00000.0000undefundefKidney0.00220.0000undef0.0000Pancreas0.00000.0000undefundefProstate0.00090.00130.72351.3821T lymphoma0.00250.0000undef0.0000Uterus0.00150.0000undef0.0000White blood cells0.00000.0000undefundefHematopoietic0.0000Penis0.0054Seminal vesicle0.0000Sensory organs0.0000FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0039Skin0.0000Hepatic0.0000Heart-blood vessels0.0071Lung0.0036Adrenal gland0.0000Kidney0.0000Placenta0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0051Endocrine tissue0.0000Fetal0.0000Gastrointestinal0.0000Hematopoietic0.0257Skin-muscle0.0000Testicles_n0.0000Testicles_t0.0000Lungs_n0.0000Lungs_t0.0000Nerves0.0010Kidney_t0.0000Ovary_uterus0.0023Prostate_n0.0000Sensory organs0.0000White blood cells0.0000Electronic Northern for Seq. ID: 154NORMALB lymphoma0.00000.0000undefundefBladder0.01560.0000undef0.0000Breast0.00790.01120.70451.4195Large intestine0.00380.0000undef0.0000Small intestine0.00270.0000undef0.0000Ovary0.01190.0000undef0.0000Endocrine tissue0.00160.0000undef0.0000Brain0.00290.00600.48352.0680Skin0.01470.0000undef0.0000Hepatic0.00930.0000undef0.0000Heart0.01120.0000undef0.0000Testicles0.00000.0000undefundefLung0.00970.00741.31550.7601Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00510.00371.39170.7186Kidney0.01120.00482.32120.4308Pancreas0.01160.0000undef0.0000Prostate0.00570.0000undef0.0000T lymphoma0.00250.00750.33812.9576Uterus0.00440.00460.96381.0375White blood cells0.00480.03040.15786.3369Hematopoietic0.0027Penis0.0080Seminal vesicle0.0070Sensory organs0.0235FETUSDevelopment0.0000Gastrointestinal0.0083Brain0.0000Hematopoietic0.0000Skin0.0000Hepatic0.0260Heart-blood vessels0.0036Lung0.0217Adrenal gland0.0000Kidney0.0000Placenta0.0000Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0000Endocrine tissue0.0000Fetal0.0185Gastrointestinal0.0122Hematopoietic0.0000Skin-muscle0.0000Testicles_n0.0042Testicles_t0.0000Lungs_n0.0000Lungs_t0.0000Nerves0.0050Kidney_t0.0000Ovary_uterus0.0000Prostate_n0.0000Sensory organs0.0000White blood cells0.0000Electronic Northern for Seq. ID: 155NORMALB lmphoma0.00750.0000undef0.0000Bladder0.01560.00473.31900.3013Breast0.00350.01970.17895.5892Large intestine0.00960.00851.12130.8918Small intestine0.01100.0000undef0.0000Ovary0.00590.00481.24430.8036Endocrine tissue0.00800.01240.64671.5464Brain0.00580.00105.80260.1723Skin0.00370.0000undef0.0000Hepatic0.00000.00630.0000undefHeart0.01220.0000undef0.0000Testicles0.02010.01181.69640.5895Lung0.00100.00740.13167.6015Stomach-esophagus0.02170.0000undef0.0000Muscle-skeleton0.00510.00740.69581.4371Kidney0.00000.0000undefundefPancreas0.01160.0000undef0.0000Prostate0.00470.00650.72351.3821T lymphoma0.01010.00751.35250.7394Uterus0.00440.00460.96381.0375White blood cells0.00480.03040.15786.3369Hematopoietic0.0040Penis0.0134Seminal vesicle0.0000Sensory organs0.0000FETUSDevelopment0.0278Gastrointestinal0.0056Brain0.0063Hematopoietic0.0118Skin0.0000Hepatic0.0000Heart-blood vessels0.0142Lung0.0108Adrenal gland0.0254Kidney0.0124Placenta0.0061Prostate0.0499Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0101Endocrine tissue0.0000Fetal0.0185Gastrointestinal0.0122Hematopoietic0.0000Skin-muscle0.0194Testicles_n0.0125Testicles_t0.0000Lungs_n0.0000Lungs_t0.0000Nerves0.0141Kidney_t0.0000Ovary_uterus0.0135Prostate_n0.0121Sensory organs0.0077White blood cells0.0000Electronic Northern for Seq. ID: 156NORMALB lymphoma0.00750.0000undef0.0000Bladder0.00000.01880.0000undefBreast0.00260.00560.46972.1292Large intestine0.00380.0000undef0.0000Small intestine0.00550.0000undef0.0000Ovary0.00590.00481.24430.8036Endocrine tissue0.00320.0000undef0.0000Brain0.00170.00300.58031.7234Skin0.00000.0000undefundefHepatic0.00460.0000undef0.0000Heart0.00510.01370.36922.7086Testicles0.00400.0000undef0.0000Lung0.00490.01290.37592.6605Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00170.00370.46392.1557Kidney0.00000.0000undefundefPancreas0.00170.01100.14966.6855Prostate0.00000.00130.0000undefT lymphoma0.00510.0000undef0.0000Uterus0.01480.00463.21280.3113White blood cells0.00070.0000undef0.0000Hematopoietic0.0053Penis0.0027Seminal vesicle0.0000Sensory organs0.0353FETUSDevelopment0.0000Gastrointestinal0.0000Brain0.0000Hematopoietic0.0118Skin0.0000Hepatic0.0000Heart-blood vessels0.0000Lung0.0072Adrenal gland0.0000Kidney0.0124Placenta0.0242Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0000Endocrine tissue0.0245Fetal0.0151Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0259Testicles_n0.0000Testicles_t0.0000Lungs_n0.0195Lungs_t0.0000Nerves0.0090Kidney_t0.0000Ovary_uterus0.0135Prostate_n0.0000Sensory organs0.0000White blood cells0.0000Electronic Northern for Seq. ID: 157NORMALB lymphoma0.01000.01360.73581.3590Bladder0.00000.00700.0000undefBreast0.01060.01410.75151.3308Large intestine0.00570.01140.50461.9818Small intestine0.00270.0000undef0.0000Ovary0.02080.02150.96781.0333Endocrine tissue0.01930.04080.47242.1170Brain0.00870.01100.79131.2638Skin0.00370.0000undef0.0000Hepatic0.00000.01900.0000undefHeart0.01010.0000undef0.0000Testicles0.03610.01183.05350.3275Lung0.01170.01850.63151.5836Stomach-esophagus0.00720.0000undef0.0000Muscle-skeleton0.00170.03690.046421.5570 Kidney0.02010.03370.59691.6754Pancreas0.01490.0000undef0.0000Prostate0.01320.02470.53311.8758T lymphoma0.01770.02990.59171.6900Uterus0.00590.00461.28510.7781White blood cells0.02190.0000undef0.0000Hematopoietic0.0094Penis0.0161Seminal vesicle0.0070Sensory organs0.0353FETUSDevelopment0.0139Gastrointestinal0.0167Brain0.0000Hematopoietic0.0039Skin0.0000Hepatic0.0000Heart-blood vessels0.0142Lung0.0036Adrenal gland0.0254Kidney0.0185Placenta0.0061Prostate0.0249Sensory organs0.0126STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0203Endocrine tissue0.0000Fetal0.0209Gastrointestinal0.0366Hematopoietic0.0000Skin-muscle0.0972Testicles_n0.0251Testicles_t0.0000Lungs_n0.0098Lungs_t0.0000Nerves0.0151Kidney_t0.0000Ovary_uterus0.0450Prostate_n0.0303Sensory organs0.0310White blood cells0.0000Electronic Northern for Seq. ID: 158NORMALB lymphoma0.00750.0000undef0.0000Bladder0.01560.00702.21270.4519Breast0.00880.01550.56931.7566Large intestine0.00770.00571.34560.7432Small intestine0.00820.0000undef0.0000Ovary0.00000.00240.0000undefEndocrine tissue0.00160.0000undef0.0000Brain0.00410.02090.19345.1701Skin0.01470.0000undef0.0000Hepatic0.00000.01900.0000undefHeart0.00410.0000undef0.0000Testicles0.01200.01181.01780.9825Lung0.01460.00552.63110.3801Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00510.01480.34792.8743Kidney0.00450.00960.46422.1540Pancreas0.00170.00550.29923.3427Prostate0.00470.00650.72351.3821T lymphoma0.00510.0000undef0.0000Uterus0.01630.02760.58901.6977White blood cells0.00000.0000undefundefHematopoietic0.0053Penis0.0107Seminal vesicle0.0000Sensory organs0.0118FETUSDevelopment0.0000Gastrointestinal0.0028Brain0.0063Hematopoietic0.0118Skin0.0000Hepatic0.0000Heart-blood vessels0.0036Lung0.0000Adrenal gland0.0000Kidney0.0124Placenta0.0061Prostate0.0499Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0000Endocrine tissue0.0000Fetal0.0041Gastrointestinal0.0000Hematopoietic0.0257Skin-muscle0.0194Testicles_n0.0000Testicles_t0.0000Lungs_n0.0098Lungs_t0.0000Nerves0.0060Kidney_t0.0000Ovary_uterus0.0068Prostate_n0.0000Sensory organs0.0000White blood cells0.0000Electronic Northern for Seq. ID: 159NORMALB lymphoma0.00500.04070.12268.1542Bladder0.00000.00470.0000undefBreast0.00970.00980.98401.0162Large intestine0.00770.01710.44852.2295Small intestine0.00550.01070.51531.9406Ovary0.00890.00721.24430.8036Endocrine tissue0.00640.01060.60361.6568Brain0.00750.00900.83821.1931Skin0.00000.0000undefundefHepatic0.00930.0000undef0.0000Heart0.00000.0000undefundefTesticles0.00800.00591.35710.7369Lung0.00680.00551.22780.8144Stomach-esophagus0.00000.00640.0000undefMuscle-skeleton0.00340.0000undef0.0000Kidney0.00450.00960.46422.1540Pancreas0.00170.0000undef0.0000Prostate0.00660.00135.06460.1974T lymphoma0.01010.00751.35250.7394Uterus0.00440.02300.19285.1876White blood cells0.00410.0000undef0.0000Hematopoietic0.0147Penis0.0027Seminal vesicle0.0000Sensory organs0.0000FETUSDevelopment0.0000Gastrointestinal0.0028Brain0.0063Hematopoietic0.0079Skin0.0000Hepatic0.0000Heart-blood vessels0.0036Lung0.0072Adrenal gland0.0254Kidney0.0247Placenta0.0121Prostate0.0000Sensory organs0.0126STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0203Endocrine tissue0.0000Fetal0.0087Gastrointestinal0.0244Hematopoietic0.0257Skin-muscle0.0097Testicles_n0.0209Testicles_t0.0000Lungs_n0.0000Lungs_t0.0000Nerves0.0030Kidney_t0.0000Ovary_uterus0.0090Prostate_n0.0000Sensory organs0.0774White blood cells0.0000Electronic Northern for Seq. ID: 160NORMALB lymphoma0.00000.0000undefundefBladder0.00780.00233.31900.3013Breast0.00090.00840.10449.5814Large intestine0.00570.0000undef0.0000Small intestine0.00270.01070.25773.8812Ovary0.00300.00480.62221.6073Endocrine tissue0.00160.00180.90541.1045Brain0.00410.00401.01550.9848Skin0.00000.0000undefundefHepatic0.01860.0000undef0.0000Heart0.00100.0000undef0.0000Testicles0.00000.0000undefundefLung0.00190.0000undef0.0000Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00170.00370.46392.1557Kidney0.00450.0000undef0.0000Pancreas0.00170.00550.29923.3427Prostate0.00090.0000undef0.0000T lymphoma0.00760.00751.01430.9859Uterus0.00300.0000undef0.0000White blood cells0.00410.0000undef0.0000Hematopoietic0.0040Penis0.0080Seminal vesicle0.0070Sensory organs0.0000FETUSDevelopment0.0000Gastrointestinal0.0111Brain0.0125Hematopoietic0.0039Skin0.0000Hepatic0.0000Heart-blood vessels0.0071Lung0.0000Adrenal gland0.0000Kidney0.0062Placenta0.0121Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0101Endocrine tissue0.0490Fetal0.0058Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0065Testicles_n0.0000Testicles_t0.0000Lungs_n0.0000Lungs_t0.0000Nerves0.0020Kidney_t0.0000Ovary_uterus0.0045Prostate_n0.0000Sensory organs0.0000White blood cells0.0000Electronic Northern for Seq. ID: 161NORMALB lymphoma0.00500.0000undef0.0000Bladder0.00780.00471.65950.6026Breast0.00090.00840.10449.5814Large intestine0.00000.0000undefundefSmall intestine0.00000.01070.0000undefOvary0.00000.00480.0000undefEndocrine tissue0.00640.01060.60361.6568Brain0.00580.00501.16050.8617Skin0.00000.0000undefundefHepatic0.00000.01900.0000undefHeart0.00410.0000undef0.0000Testicles0.00400.01180.33932.9475Lung0.00390.00182.10490.4751Stomach-esophagus0.00000.0000undefundefMuscle-skeleton0.00000.0000undefundefKidney0.00220.00480.46422.1540Pancreas0.00500.00550.89751.1142Prostate0.08480.06511.30230.7679T lymphoma0.00760.00751.01430.9859Uterus0.00590.00461.28510.7781White blood cells0.00410.0000undef0.0000Hematopoietic0.0027Penis0.0027Seminal vesicle0.0000Sensory organs0.0000FETUSDevelopment0.0000Gastrointestinal0.0056Brain0.0000Hematopoietic0.0039Skin0.0000Hepatic0.0000Heart-blood vessels0.0000Lung0.0036Adrenal gland0.0507Kidney0.0000Placenta0.0121Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Breast_t0.0000Large intestine_t0.0000Ovary_n0.0000Ovary_t0.0000Endocrine tissue0.0000Fetal0.0104Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0097Testicles_n0.0084Testicles_t0.0000Lungs_n0.0000Lungs_t0.0000Nerves0.0050Kidney_t0.0000Ovary_uterus0.0000Prostate_n0.0546Sensory organs0.0000White blood cells0.0000Electronic Northern for SEQ. ID NO.: 201NORMALBladder0.00000.00770.0000undefBreast0.00270.03050.087411.4458 Ovary0.00300.08330.036527.3828Endocrine tissue0.00180.01090.16745.9721Gastrointestinal0.00000.00480.0000undefBrain0.05760.05481.05280.9499Hematopoietic0.00420.0000undef0.0000Skin0.00990.16930.058717.0262 Hepatic0.04460.18120.24594.0660Heart0.01380.01371.00200.9980Testicles0.00000.10520.0000undefLungs0.00870.08510.10249.7640Stomach-esophagus0.00000.02300.0000undefMuscle-skeleton0.02740.28200.097210.2887 Kidneys0.34480.42450.81231.2311Pancreas0.12680.03873.28140.3047Penis0.00300.0000undef0.0000Prostate0.00000.00210.0000undefUterus0.00330.04270.077412.9263 Breast hyperplasia0.0073Small intestine0.0000Prostatic hyperplasia0.0059Seminal vesicles0.0000Sensory organs0.0118White blood cells0.1958FETUSDevelopment0.0922Gastrointestinal0.0247Brain0.0000Hematopoietic0.0079Heart-blood vessels0.0123Lungs0.0037Kidneys0.0062Prostate0.0000Sensory organs0.1815STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0000Endocrine tissue0.0000Fetal0.0134Gastrointestinal0.0000Hematopoietic0.0000Skin-muscle0.0032Testicles0.0000Lungs0.0164Nerves0.0231Prostate0.0064Sensory organs0.0310Electronic Northern for SEQ. ID NO.: 202NORMALBladder0.00000.07920.0000undefBreast0.00400.02610.15296.5404Ovary0.00910.01560.58431.7114Endocrine tissue0.00360.00271.33960.7465Gastrointestinal0.01740.01431.22140.8187Brain0.00000.00440.0000undefHematopoietic0.00560.0000undef0.0000Skin0.01990.0000undef0.0000Hepatic0.01990.06470.30613.2673Heart0.00110.0000undef0.0000Testicles0.00610.0000undef0.0000Lungs0.02240.01181.89620.5274Stomach-esophagus0.01930.0000undef0.0000Muscle-skeleton0.00340.0000undef0.0000Kidneys0.01780.00682.60500.3839Pancreas0.00190.03310.057117.5010 Penis0.00600.08000.074913.3560 Prostate0.00950.00641.49150.6705Uterus0.00170.0000undef0.0000Breast hyperplasia0.0000Small intestine0.0031Prostatic hyperplasia0.0119Seminal vesicles0.0000Sensory organs0.0235White blood cells0.0000FETUSDevelopment0.0000Gastrointestinal0.0092Brain0.0063Hematopoietic0.0000Heart-blood vessels0.0000Lungs0.0259Kidneys0.0062Prostate0.0000Sensory organs0.0000STANDARDIZED/SUBTRACTEDLIBRARIESBreast0.0000Ovary-uterus0.0068Endocrine tissue0.0000Fetal0.0274Gastrointestinal0.0122Hematopoietic0.0000Skin-muscle0.0000Testicles0.0000Lungs0.0410Nerves0.0000Prostate0.0064Sensory organs0.0000


[0087] 2.2. Fisher Test


[0088] In order to decide whether a partial sequence S of a gene occurs significantly more often or less often in a library for normal tissue than in a library for degenerated tissue, Fisher's exact test, a standard statistical process, is carried out (Hays, W. L., (1991) Statistics, Harcourt Brace College Publishers, Fort Worth).


[0089] The null hypothesis reads: The two libraries cannot be distinguished with respect to the frequency of sequences homologous to S. If the null hypothesis can be rejected with high enough certainty, the gene belonging to S is accepted as an advantageous candidate for a cancer gene, and in the next step an attempt is made to achieve lengthening of its sequence.



EXAMPLE 3

[0090] Automatic Lengthening of the Partial Sequence


[0091] Automatic lengthening of partial sequence S is completed in three steps:


[0092] 1. Determination of all sequences homologous to S from the total set of available sequences using BLAST.


[0093] 2. Assembling these sequences by means of the standard program GAP4 (Bonfield, J. K.; Smith, K. F. and Staden, R. (1995), Nucleic Acids Research 23 4992-4999) (contig formation).


[0094] 3. Computation of a consensus sequence C from the assembled sequences.


[0095] The consensus sequence C will generally be longer than initial sequence S. Its electronic Northern Blot will accordingly deviate from that for S. A repeated Fisher test decides whether the alternative hypothesis of deviation from a uniform expression in the two libraries can be maintained. If this is the case, an attempt is made to lengthen C in the same way as S. This iteration is continued with consensus sequences Ci (i: iteration index) obtained in each case until the alternative hypothesis is rejected (if H0 Exit; truncation criterion I) or until automatic lengthening is no longer possible (while Ci>Ci−1; truncation criterion II).


[0096] In the case of truncation criterion II, with the consensus sequence present after the last iteration, a complete or roughly complete sequence of a gene which can be related to cancer with high statistical certainty is acquired.


[0097] Analogously to the above-described examples, it was possible to find the nucleic acid sequences described in Table I from breast tumor tissue.


[0098] Furthermore, for the individual nucleic acid sequences, it was possible to determine the peptide sequences (ORFs) that are listed in Table II, in which no peptide can be assigned to a few nucleic acid sequences and more than one peptide can be assigned to some nucleic acid sequences. As already mentioned above, both the determined nucleic acid sequences and the peptide sequences assigned to the nucleic acid sequences are the subject of this invention.



EXAMPLE 4

[0099] Mapping of Nucleic Acid Sequences on the Human Genome


[0100] Human genes were mapped using the Stanford G3 Hybrid Panel (Stewart et al., 1997), which is marketed by Research Genetics, Huntsville, Ala. This panel consists of 83 different genomic DNAs of human-hamster hybrid cell lines and allows resolution of 500 kilobases. The hybrid cell lines were obtained by fusion of irradiated diploid human cells with cells of the Chinese hamster. The retention pattern of the human chromosome fragments is determined by means of gene-specific primers in a polymerase chain reaction and is analyzed using software available from the Stanford RH server (http://www.stanford.edu/RH/rhserver_form2. html). This program determines the STS marker that is nearest to the desired gene. The corresponding cytogenetic band was determined using the “Mapview” program of the Genome Database (GDB), (http://gdbwww.dkfz-heidelberg.de).


[0101] In addition to mapping of genes on the human chromosome set by various experimental methods, it is possible to determine the location of genes on this by biocomputer methods. To do this, the known program e-PCR was used (Schuler G D (1998) Electronic PCR: Bridging the gap between genome mapping and genome sequencing. Trends Biotechnol 16: 456-459, Schuler G D (1997). Sequence mapping by electronic PCR. Genome Res. 7: 541-550). The database used here no longer corresponds to the one cited in the literature, but is a further development which includes data from the public database RHdb (http://www.ebi.ac.uk/RHdb/-index.html). Analogously to the mapping by the hybrid panels, the results were evaluated with the above-mentioned software and the software of the Whitehead Institute (http://carbon.wi.mit.edu:8000/cgi-bin/contig/rhmapper.pl).



EXAMPLE 5

[0102] Obtaining Genomic DNA Sequences (BAC Clones)


[0103] The genomic sequences that correspond to the differential cDNAs were isolated from commercial BAC libraries. BAC libraries of the Genome Systems Company, St. Louis, Mo., which were produced from human lymphocytes, were used (http://www.genomesystems.com) and those of the Research Genetics Company, which were described as follows, were used: Shizuya, H.; B. Birren, U-J. Kim, V. Mancino, T. Slepak, Y. Tachiiri, M. Simon (1992) Proc. Natl. Acad. Sci., USA 89: 8794-8797; http://www.tree.caltech.edu/. From these libraries, the BAC clones with the procedure of “down-to-the-well” were isolated. In this procedure, a library consisting of BAC clones (the library covers roughly 3× the human genome) is combined in various groups. This takes place in such a way that after the execution of a gene-specific PCR in the various pools, a definite clone assignment is possible. This address together with the name of the library which is being used unequivocally fixes the clones and thus the DNA sequence of these clones.


[0104] The following examples explain the successful isolation of the genomic BAC clones without limiting them thereto.


[0105] The libraries of genome systems used were CITB B and CITB C. Clones from the library of genome systems are underlined. Breast Tumor
5Seq. IDNo.Identified BACs3431/F/22461/J/18276/D/4360/G/5276/D/57241/D/11913/M/23102/H/20210/0/17278/B/10278/B/2010319/P/11492/J/1523565/E/82538/D/460/B/1770/K/1439425/C/1842221/L/9407/M/943233/F/11411/C/6411/C/8461/C/2045557/D/1558222/C/8431/0/16


[0106]

6








TABLE I













Col. 1
Seq ID No.



Col. 2
Expression



Col. 3
Function



Col. 4
Modules



Col. 5
Length of the applied sequence (bp)



Col. 6
Chromosomal localization



Col. 7
Marker













Seq




ID No.
Expression
Function





 2
Overexpressed in
A 17-kDA interferon-induced gene—



the breast tumor
nothing is published on its function


 3
Overexpressed in
Presumably the human ortholog of the



the breast tumor
5E5-antigen of rats, in this connection




it is probably a transcription factor.


 4
Overexpressed in
The human “alpha-2-macroglobulin



the breast tumor
receptor-associated protein” belongs to




a “proteinase-scavenging system” that




recovers proteinase activity.


 5
Overexpressed in
The human “macrophage migration



the breast tumor
inhibition factor related protein 14




(MRP-14)” probably plays a role in




immunomodulation.


 6
Overexpressed in
The human lamin B2 (LAMB2) forms,



the breast tumor
i.a., the nuclear lamina, which lies




below the inside cell membrane of the




nucleus. It plays an important role in




the regulation of the nuclear structure




during the cell cycle and the




transcription.


 7
Overexpressed in
Presumably the regulatory subunit of



the breast tumor
an RNA-binding protein,; nothing was




published on its function.


 8
Overexpressed in
The human antioxidant enzyme AOE37-



the breast tumor
2, which presumably represents a




peroxidase (peroxiredoxin family).




The latter protect the cells from




oxidative processes.


 9
Overexpressed in
Unknown



the breast tumor


 11
Overexpressed in
The human “macrophage capping



the breast tumor
protein,” recently named “CapG,”




regulates the cell mobility via the actins.


 12
Overexpressed in
An estrogen-inducible gene (LIV-1),



the breast tumor
whose function is not yet understood.


 13
Overexpressed in
The human “integrin-linked kinase



the breast tumor
(ILK)” controls the assembly of the




fibrinectin matrix and inhibits the




synthesis of E-cadherin. ILK-




coverexpressing cells produce tumors




in nude mice.


 14
Overexpressed in
Unknown, human HISTONE H2B2



the breast tumor


 15
Overexpressed in
Presumably the human ortholog of



the breast tumor
the enhancer of the Drosophila




“rudimentary” gene (“human enhancer




of rudimentary homolog”); it possibly




plays a role in the pyrimidine




metabolism.


 16
Overexpressed in
The human Tim23 is localized in the



the breast tumor
protein translocase complex of the




inside mitochondrial membrane.


 17
Overexpressed in
Presumably a new Ca2+-binding



the breast tumor
protein.


 18
Overexpressed in
A new human gene with similarity to



the breast tumor
the mouse “synaptosomal associated




protein.”


 19
Overexpressed in
The human ITF (“intestinal trefoil



the breast tumor
factor“).


 20
Overexpressed in
The human RNA polymerase II



the breast tumor
transcription factor.


 21
Overexpressed in
Unknown



the breast tumor


 22
Overexpressed in
The human JAK1 tyrosine kinase.



the breast tumor


 23
Overexpressed in
Unknown



the breast tumor


 24
Overexpressed in
Unknown



the breast tumor


 25
Overexpressed in
Unknown



the breast tumor


 27
Overexpressed in
Unknown



the breast tumor


 29
Overexpressed in
The human ribonuclease 6-precursor



the breast tumor
molecule.


 30
Overexpressed in
The human 80K-L protein (also



the breast tumor
MARCKS), a substrate of the protein




kinase C. MARCKS binds calmodulin,




actin and synapsin.


 31
Overexpressed in
The human BCL-X, an apoptosis



the breast tumor
regulator.


 33
Overexpressed in
The human benzodiazepine receptor.



the breast tumor


 35
Overexpressed in
The human ubiquinone oxidoreductase.



the breast tumor


 36
Overexpressed in
A new ATPase, which belongs to the



the breast tumor
kinesin family.


 37
Overexpressed in
The monocyte/macrophage “Ig-



the breast tumor
related receptor MIR-7.”


 38
Overexpressed in
Unknown



the breast tumor


 39
Overexpressed in
A new putative serine/threonine



the breast tumor
kinase.


 40
Overexpressed in
The putative copper-receiving



the breast tumor
protein hCTR2.


 41
Overexpressed in
The human alpha galactosidase A.



the breast tumor


 42
Overexpressed in
Unknown



the breast tumor


 43
Overexpressed in
This new sequence has a certain



the breast tumor
homology to the benzoate-coenzyme A




ligase.


 44
Overexpressed in
7TM protein



the breast tumor


 45
Overexpressed in
The human phosphatase 2A B56



the breast tumor
(PP2A).


 46
Overexpressed in
HUMAN homolog to a mouse co-



the breast tumor
chaperonin; Hs. 24930; homo sapiens




cofactor A protein mRNA


 47
Overexpressed in
Homolog to an imprinted gene of



the breast tumor
chromosome 11; Hs. 110222


 48
Overexpressed in
Presumably the human ortholog of



the breast tumor
an ATP-dependent RNA-helicase.


 49
Overexpressed in
Coupling factor F6 is a component of



the breast tumor
the mitochondrial ATP-synthase, which




is necessary for the interaction of




catalytic and proton-transferring




segments; Hs. 73851


 50
Overexpressed in
Unknown



the breast tumor


 51
Overexpressed in
New human ATPase



the breast tumor


 52
Overexpressed in
Unknown; Hs. 10927



the breast tumor


 53
Overexpressed in
Homolog to the NAG-2 gene; Hs.



the breast tumor
26518


 54
Overexpressed in
Arginine methyltransferase; Hs.



the breast tumor
20521


 55
Overexpressed in
Unknown; Hs. 5241



the breast tumor


 56
Overexpressed in
Stromelysine



the breast tumor


 57
Overexpressed in
Human GTP-binding protein



the breast tumor


 58
Overexpressed in
Homolog to prostate-binding protein,



the breast tumor
subunit C-1


 59
Overexpressed in
Unknown



the breast tumor


 61
Overexpressed in
Glucose-6-phosphate dehydrogenase



the breast tumor
homolog


 62
Overexpressed in
Unknown



the breast tumor


 63
Overexpressed in
Unknown



the breast tumor


 64
Overexpressed in
Ets transcription factor



the breast tumor


 65
Overexpressed in
IL 13 receptor alpha-1 chain



the breast tumor


 66
Overexpressed in
Inhibition of cell division and the



the breast tumor
macrophage activity. Protein-kinase




inhibitor


 67
Overexpressed in
Possibly a dehydrogenase



the breast tumor


149
Overexpressed in
Lengthening to Seq. ID No. 4



the breast tumor


150
Overexpressed in
Lengthening to Seq. ID No. 9



the breast tumor


151
Overexpressed in
Lengthening to Seq. ID No. 25



the breast tumor


152
Overexpressed in
Lengthening to Seq. ID No. 27



the breast tumor


153
Overexpressed in
Lengthening to Seq. ID No. 44



the breast tumor


154
Overexpressed in
Lengthening to Seq. ID No. 45



the breast tumor


155
Overexpressed in
Lengthening to Seq. ID No. 48



the breast tumor


156
Overexpressed in
Lengthening to Seq. ID No. 50



the breast tumor


157
Overexpressed in
Lengthening to Seq. ID No. 51



the breast tumor


158
Overexpressed in
Lengthening to Seq. ID No. 53



the breast tumor


159
Overexpressed in
Lengthening to Seq. ID No. 62



the breast tumor


160
Overexpressed in
Lengthening to Seq. ID No. 63



the breast tumor


161
Overexpressed in
Lengthening to Seq. ID No. 67



the breast tumor


201
Overexpressed in
The human osteopontin.



the breast tumor


202
Overexpressed in
Proteoglycan



the breast tumor






[Key:]




unbekannt = unknown








[0107]

7








TABLE II











DNA Sequence
Peptide Sequence



Seq. ID. No.
(ORF's) Seq. ID. No.























 3
 71







 9
 72
 73
 74
 75
 76



 14
 77



 16
 78



 17
 79



 18
 81



 19
 82



 20
 83



 21
 84
 85
 86
 87



 23
 88
 89



 24
 90



 25
 91



 27
 92
 93



 29
 94



 31
 95
 96
 97
 98



 33
 99
100



 35
101



 36
102



 38
103



 39
104



 40
105



 41
106



 42
107



 43
108
109
110



 44
111
112
113



 46
114



 47
115
116



 48
117



 49
118
119



 50
120



 51
121



 52
123



 53
126



 54
128



 55
129
130
131
132
133



 56
134
135



 57
136



 58
137



 59
138
139



 61
140



 62
141



 63
142
143
144



 64
145



 66
146



 67
147



149
162
163
164



150
165
166
167



151
168



152
172



153
174



154
177
178
179



155
180



156
183
184
185



157
187



158
190



159
192
193
194



160
195
196
197



161
198











[0108] The inventive nucleic acid sequences Seq. ID No. 2-67, 149-161, and 201-202 of the determined candidate genes and the determined amino acid sequences Seq. ID No. 71-148, and 162-200 are described in the following sequence protocol.


Claims
  • 1. A nucleic acid sequence that codes a gene product or a part thereof, comprising a) a nucleic acid sequence, selected from the group Seq. Id no. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 156-158, and 160-161 b) an allelic variation of the nucleic acid sequences named under a) or c) a nucleic acid sequence that is complementary to the nucleic acid sequences named under a) or b).
  • 2. A nucleic acid sequence according to one of the sequences Seq. ID No. 3, 7, 9, 15, 17, 18, 21, 25, 27, 33, 35, 36, 38, 39, 40, 42, 43, 44, 46, 47, 48, 50, 51, 52, 53, 54, 55, 57, 58, 59, 61, 62, 63, 65, 66, 67, 150-153, 156-158, 160-161 or a complementary or allelic variant thereof.
  • 3. Nucleic acid sequence Seq. ID No. 2-67, 149-161, 201-202, characterized in that it is expressed elevated in breast tumor tissue.
  • 4. BAC, PAC and Cosmid clones containing functional genes and their chromosomal localization according to sequences Seq. ID No. 2-67, 149-161, and 201-202 for use as a vehicle for gene transfer.
  • 5. A nucleic acid sequence according to claims 1 to 4, wherein it has 90% homology to a human nucleic acid sequence.
  • 6. A nucleic acid sequence according to claims 1 to 4, wherein it has 95% homology to a human nucleic acid sequence.
  • 7. A nucleic acid sequence comprising a portion of the nucleic acid sequences named in claims 1 to 6, in such a sufficient amount that they hybridize with the sequences according to claims 1 to 6.
  • 8. A nucleic acid sequence according to claims 1 to 7, wherein the size of the fragment has a length of at least 50 to 4500 bp.
  • 9. A nucleic acid sequence according to claims 1 to 7, wherein the size of the fragment has a length of at least 150 to 4000 bp.
  • 10. A nucleic acid sequence according to one of claims 1 to 9, which codes at least one partial sequence of a bioactive polypeptide.
  • 11. An expression cassette, comprising a nucleic acid fragment or a sequence according to one of claims 1 to 9, together with at least one control or regulatory sequence.
  • 12. An expression cassette, comprising a nucleic acid fragment or a sequence according to claim 11, in which the control or regulatory sequence is a suitable promoter.
  • 13. An expression cassette according to one of claims 11 and 12, wherein the DNA sequences located on the cassette code a fusion protein, which comprises a known protein and a bioactive polypeptide fragment.
  • 14. Use of nucleic acid sequences according to claims 1 to 10 for producing full-length genes.
  • 15. A DNA fragment, comprising a gene, that can be obtained from the use according to claim 14.
  • 16. Host cell, containing as the heterologous part of its expressible genetic information a nucleic acid fragment according to one of claims 1 to 10.
  • 17. Host cell according to claim 16, wherein it is a prokaryotic or eukaryotic cell system.
  • 18. Host cell according to one of claims 16 or 17, wherein the prokaryotic cell system is E. coli and the eukaryotic cell system is an animal, human or yeast cell system.
  • 19. A process for producing a polypeptide or a fragment, wherein the host cells according to claims 16 to 18 are cultivated.
  • 20. An antibody that is directed against a polypeptide or a fragment that is coded by the nucleic acids of sequences Seq. ID No. 2-67, 149-161, and 201-202, which can be obtained according to claim 19.
  • 21. An antibody according to claim 20, wherein it is monoclonal.
  • 22. Polypeptide partial sequences according to sequences Seq. ID No. 71-148, and 162-198.
  • 23. Polypeptide partial sequences according to claim 22, with at least 80% homology to these sequences.
  • 24. Polypeptide partial sequences according to claim 22, with at least 90% homology to these sequences.
  • 25. Use of polypeptide partial sequences according to sequences Seq. ID No. 71-148, and 162-198 as tools for finding active ingredients against breast cancer.
  • 26. Use of nucleic acid sequences according to sequences Seq. ID No. 2-67, 149-161 and 201-202 for expression of polypeptides that can be used as tools for finding active ingredients against breast cancer.
  • 27. Use of nucleic acid sequences Seq. ID No. 2-67, 149-161, and 201-202 in sense or antisense form.
  • 28. Use of polypeptide partial sequences Seq. ID No. 71-148 and 162-198 as pharmaceutical agents in gene therapy for treatment of breast cancer.
  • 29. Use of polypeptide partial sequences Seq. ID No. 71-148, and 162-198 for the production of a pharmaceutical agent for treatment of breast cancer.
  • 30. Pharmaceutical agent, containing at least one polypeptide partial sequence Seq. ID No. 71-148, and 162-198.
  • 31. A nucleic acid sequence according to claims 1 to 10, wherein it is a genomic sequence.
  • 32. A nucleic acid sequence according to claims 1 to 10, wherein it is an mRNA sequence.
  • 33. Genomic genes, their promoters, enhancers, silencers, exon structure, intron structure and their splice variants, that can be obtained from cDNAs of sequences Seq. ID No. 2-67, 149-161 and 201-202.
  • 34. Use of the genomic genes according to claim 33, together with suitable regulatory elements.
  • 35. Use according to claim 34, wherein the regulatory element is a suitable promoter and/or enhancer.
  • 36. A nucleic acid sequence according to claims 1 to 7, wherein the size of the fragment has a length of at least 450 to 3500 bp.
Priority Claims (1)
Number Date Country Kind
198 13 839.3 Mar 1998 DE
Divisions (1)
Number Date Country
Parent 09646673 Sep 2000 US
Child 10131410 Apr 2002 US