Claims
- 1. A method for determining the distribution of an active agent in a tissue, said method comprising:
(a) screening a PET-ready library of potential agents against a biological target; (b) identifying at least one of said potential agents as an active agent; (c) preparing a PET-labeled version of said active agent, wherein said preparing comprises incorporating a PET-label into the final or penultimate step of active agent synthesis; (d) administering said PET-labeled version of said active agent to a subject; and (e) measuring the distribution of said active agent in at least one tissue of said subject.
- 2. A method in accordance with claim 1, wherein said PET-label is selected from the group consisting of 11C, 18F, 76Br, 124I and 13N.
- 3. A method in accordance with claim 1, wherein said PET-ready library of potential agents is prepared using solid phase methods,
- 4. A method in accordance with claim 1, wherein said final or penultimate step of active agent synthesis is an alkylation step.
- 5. A method in accordance with claim 1, wherein said final or penultimate step of active agent synthesis is a methylation step.
- 6 A method in accordance with claim 1, wherein said final or penultimate step of active agent synthesis is an acetylation step.
- 7 A method in accordance with claim 1, wherein said PET-ready library comprises from about 12 to about 144 potential agents.
- 8. A method in accordance with claim 1, wherein said PET-ready library is prepared on a resin.
- 9. A method in accordance with claim 1, wherein said subject is selected from the group consisting of a mouse, rat, dog, cat, sheep, monkey and human.
CROSS-REFERENCES TO RELATED APPLICATIONS
[0001] This application claims the benefit of Provisional Application Serial No. 60/160,918, filed Oct. 22, 1999, the disclosure of which is incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60160918 |
Oct 1999 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09693410 |
Oct 2000 |
US |
Child |
10739828 |
Dec 2003 |
US |