Claims
- 1. An interleukin 6 receptor antagonist, wherein residue Tyr31 of human interleukin 6 is replaced with Asp and residue Gly35 of human interleukin 6 is replaced with Tyr, Phe or Leu.
- 2. The interleukin 6 receptor antagonist according to claim 1, wherein residue Ser118 of human interleukin 6 is replaced with Arg, Phe or Leu and residue Val121 of human interleukin 6 is replaced with Asp.
- 3. The interleukin 6 receptor antagonist according to claim 2, wherein human interleukin 6 residue Tyr31 is replaced with Asp, Gly35 is replaced with Phe, Ser118 is replaced with Arg, and Val121 is replaced with Asp.
- 4. The interleukin 6 receptor antagonist according to claim 3, wherein human interleukin 6 residue Tyr31 is replaced with Asp, Gly35 is replaced with Phe, Ser118 is replaced with Arg, Val121 is replaced with Asp, Gln175 is replaced with Ile, Ser176 is replaced with Arg, and Gln183 is replaced with Ala.
- 5. The interleukin 6 receptor antagonist according to claim 2, wherein human interleukin 6 residue Tyr31 is replaced with Asp, Gly35 is replaced with Phe, Ser118 is replaced with Phe, and Val121 is replaced with Asp.
- 6. The interleukin 6 receptor antagonist according to claim 2, wherein human interleukin 6 residue Tyr31 is replaced within Asp, Gly35 is replaced with Phe, Ser118 is replaced with Leu, and Val121 is replaced with Asp.
Priority Claims (1)
Number |
Date |
Country |
Kind |
RM93A0409 |
Jun 1993 |
ITX |
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Parent Case Info
This is a division of parent application Ser. No. 08/387,924, filed Feb. 23, 1995, now abandoned, which is the national stage application of PCT/IT94/00095, filed Jun. 23, 1994.
US Referenced Citations (3)
Number |
Name |
Date |
Kind |
5132403 |
Kishimoto |
Jul 1992 |
|
5210075 |
Scholz et al. |
May 1993 |
|
5506107 |
Cunningham et al. |
Apr 1996 |
|
Non-Patent Literature Citations (1)
Entry |
Rudinger, J. 1976. Characteristics of the amino acids as components of apide hormone sequence. In: Parsons JA, ed. Peptide hormones. Baltimore, Univ Park Press. pp. 1-7, 1976. |
Divisions (1)
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Number |
Date |
Country |
Parent |
387924 |
Feb 1995 |
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