Lane, D.P., et al., "On the Regulation of the p53 Tumor Suppressor, and its Role in the Cellular Response to DNA Damage," Phil. R. Soc. Lond. B, 347:83-87 (1995). |
Barak, Y., et al., "mdm2 expression is induced by wild type p53 activity," EMBO Journ., 12:461-468 (1993). |
Barak, Y. & M. Oren, "Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest," EMBO Journ., 11:2115-2121 (1992). |
Brown, D. R., et al., "The Tumor Suppressor p53 and the Oncoprotein Simian Virus 40 T Antigen Bind to Overlapping Domains on the MDM2 Protein," Molec. Cell. Biol., 13:6849-6857 (1993). |
Cahilly-Snyder, L., et al., "Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell," Somatic Cell and Molecular Genetics, 13:235-244 (1987). |
Chen, J., et al., "Mapping of the p53 and mdm-2 interaction domains," Mol. Cell. Biol., 13:4107-4114 (1993). |
Dyson, N., et al., "Adenovirus E1A Makes Two Distinct Contacts with the Retinoblastoma Protein," J. Virol., 66:4606-4611 (1992). |
Dyson, N., et al., "Homologous Sequences in Adenovirus E1A and Human Papillomavirus E7 Proteins Mediate Interaction with the Same Set of Cellular Proteins," J. Virol., 66:6893-6902 (1992). |
Farmer, G., et al., "Wild-type p53 activates transcription in vitro," Nature, 358:83-86 (1992). |
Funk, W. D., et al., "A transcriptionally active DNA-binding site for human p53 protein complexes," Mol. Cell. Biol., 12:2866-2871 (1992). |
Kern, S. E., et al., "Oncogenic forms of p53 inhibit p53-regulated gene expression," Science, 256:827-830 (1992). |
Michalovitz, D., et al., "Conditional inhibition of transformation and of cell proliferation by a temperature-sensitve mutant of p53," Cell, 62:671-680 (1990). |
Momand, J., et al., "The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53 mediated transactivation," Cell, 69:1237-1245 (1992). |
Oliner, J.D., et al., "Oncoprotein mdm2 conceals the activation domain of tumour suppressor p53," Nature, 362:857-860 (1993). |
Unger, T., et al., "p53: A transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer", EMBO Journ., 11:1383-1390 (1992). |
Picksley, S.M. & D.P. Lane, "The p53-mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?" BioEssays, 15:689-690 (1993). |
Lin, J. et al., "Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein," Genes & Develop., 8:1235-1246 (1994). |
Schlichtholtz, B., et al., "The Immune Response to p53 in Breast Cancer Patients is Directed Against Immunodominant Epitopes Unrelated to Mutational Hot Spot," Canc. Res., 52:6380-6384 (1993). |
Wu, X., et al., "The p53-mdm2 autoregulatory feedback loop," Genes & Develop., 7:1126-1132 (1993). |
Picksley, S. M., et al., "Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides," Oncogene, 9:2523-2529 (1994). |
Deffie, A., et al., "The tumor suppressor p53 regulates its own transcription," Mol. Cell. Biol., 13:3415-2423 (1993). |
Liu, X., et al., "The p53 activation domain binds the TATA box-binding polypeptide in holo-TFIID, and a neighboring p53 domain inhibits transcription," Mol. Cell. Biol., 13:3291-3300 (1993). |
Oliner, J.D., et al, "Amplification of a gene encoding a p53-associated protein in hunan sarcomas," Nature, 358:80-83 (1992). |
Lane, D., et al., Overheads presented in conjunction with talk given Oncogenes EMBL Symposium at Heidelberg on Apr. 20, 1994. |
Picksley, S. M. and D. P. Lane, "p53 and Rb: their cellular roles", Current Opinion in Cell Biology 6:853-858 (1994). |
Martin, K., et al., "Stimulation of E21F1/DP1 Transcriptional Activity by MDM2 Oncoprotein," Nature 375:691-698 (1995). |
Marston, N.J., et al., "Interaction of p53 with MDM2 is Independent of E6 and Does Not Mediate Wild Type Transformation Suppressor Function," Oncogene 9:2707-2716 (1994). |