Claims
- 1. An isolated, vascular endothelium-associated glycoprotein consisting of four subunits having apparent molecular weights of 190,000 daltons, 140,000 daltons, 125,000 daltons, and 110,000 daltons as determined by SDS-PAGE under reducing conditions and an apparent molecular weight of 500,000 daltons as determined by SDS-PAGE under non-reducing conditions, said glycoprotein being that recognized by the monoclonal antibody H572 which is produced by the hybridoma deposited with the ATCC under accession number HB 11608.
- 2. Immunogenic composition comprising the glycoprotein of claim 1 and an adjuvant.
Parent Case Info
This is a division application of application Ser. No. 08/243,288, filed May 17, 1994, now pending.
Government Interests
This application is based upon work supported, in part, by a grant from the National Cancer Institute (CA-57486). The U.S. government may have certain rights in the invention.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5342757 |
Garin-Chesa et al. |
Aug 1994 |
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Foreign Referenced Citations (1)
Number |
Date |
Country |
9411023 |
May 1994 |
WOX |
Non-Patent Literature Citations (5)
Entry |
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Garin-Chesa et al., "Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers", Proc. Natl. Acad. Sci. USA 87: 7235-7239 (Sep.1990). |
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Divisions (1)
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Number |
Date |
Country |
Parent |
243288 |
May 1994 |
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