Claims
- 1. An isolated TRBP polypiptide which has an overall amino acid sequence homology of a least about 90% with the amino acid sequence set forth in SEQ ID No. 2.
- 2. An isolated TRBP polypeptide, comprising a polypeptide, which is encoded by a nucleic acid that hybridizes under high stringency conditions so SEQ ID No. 1.
- 3. An isolated TRBP polypeptide, comprising a polypeptide, which is encoded by a nucleic acid that hybridizes under high stringency conditions to the TRBP nucleic acid in the BAC clone having ATCC Designation No. 98407.
- 4. An isolated TRBP polypeptide of claim 1 wherein the TRBP polypeptide comprises an amino acid sequence of at least about 17 consecutive amino acids from about amino acid residue 1 to about amino acid residue 255 of SEQ ID No. 2.
- 5. An isolated TRBP polypeptide of claim 1 wherein the TRBP polypeptide comprises an amino acid sequence of at least about 2 consecutive amino acids from about amino residue 1 to about amino acid residue 187 of SEQ ID No. 2.
- 6. An isolated TRBP polypeptide of claim 1 wherein the TRBP polypeptide comprises an amino acid sequence which is at least about 70% homologous to at least about 10 consecutive amino acid residues from about amino acid residue 1 to about amino acid residue 187 of SEQ ID No. 2.
- 7. An isolated TRBP polypeptide of claim 1 wherein the TRBP polypeptide comprises at least about 100 consecutive amino acids of SEQ ID No. 2.
- 8. An isolated TRBP polypeptide of claim 1 wherein the TRBP polypeptide comprises an amino acid sequence which is at least about 99% homologous to at least about 126 consecutive amino acids of SEQ ID No. 2.
- 9. An isolated TRBP polypeptide of claim 1 wherein the TRBP polypeptide has the amino acid sequence set forth in SEQ ID No. 2.
- 10. An isolated TRBP polypeptide of claim 1 wherein the TRBP polypeptide binds to a thyroid hormone receptor.
- 11. An isolated polypeptide which has an overall amino acid sequence homology of at least about 95% with the amino acid sequence set forth in SEQ ID No. 2.
- 12. An isolated polypeptide which has an overall amino acid sequence homology of at least about 98% with the amino acid sequence set forth in SEQ ID No. 2.
- 13. An isolated polypeptide which has an overall amino acid sequence homology of at least about 99% with the amino acid sequence set forth in SEQ ID No. 2.
- 14. An isolated polypeptide comprising a thyroid hormone receptor binding domain of a polypeptide having SEQ ID No. 2.
- 15. An isolated polypeptide of claim 14, wherein the domain comprises amino acid residues 260-416 of SEQ ID No: 2.
- 16. An isolated polypeptide comprising an amino acid sequence which has at least 99% homology to at least 126 consecutive amino acids of SEQ ID No. 2.
- 17. An isolated polypeptide comprising an ATP binding domain of SEQ ID NO: 2.
- 18. An isolated polypeptide comprising a double stranded RNA binding domain of SEQ ID NO: 2.
RELATED APPLICATIONS
This application is a divisional of U.S. patent application Ser. No. 08/840,164, which was filed on Apr. 11, 1997.
Non-Patent Literature Citations (1)
Entry |
Lee et al., Swissprot 37, Accession #Q15646, Nov. 1997. |
Divisions (1)
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Number |
Date |
Country |
Parent |
840146 |
Apr 1997 |
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