Kit and method for determining hla type

TECHNICAL FIELD

[0001] The present invention relates to a typing kit and typing method for determining HLA genotypes. HLA typing is carried out to judge possibility of transplantation between immunogenetically different individuals. Specifically, its purpose is to provide genetic information to determine transplantation compatibility for transplantation of an organ or tissue such as bone marrow, kidney, liver, pancreas, islets of Langerhans or cornea. The kit of the present invention can also be applied to susceptibility test for a specific disease that is caused by a hereditary factor, or individual identification.

[0002] The present invention further relates to PCR primers used for the aforementioned kit and method and a method for producing the same.

BACKGROUND ART

[0003] 1. Human Leukocyte Antigen (HLA) Types and Importance of Histocompatibility

[0004] In autogenous transplantation or transplantation between immunogenetically homologous individuals such as identical twins of a tissue or cells, a graft is taken without inducing rejection reactions. On the other hand, in transplantation between immunogenetically different individuals such as other family members or unrelated individuals (allogenic transplantation) or transplantation between different species such as human being and other primates (interspecific transplantation), transplantation immunity is established and a rejection reaction is induced against a graft. There are antigens inducing particularly intense transplantation immunity as targets in this reaction, which are called major histocompatibility antigens. These antigens are controlled by a group of genes called MHC (Major Histcompatibility Complex). MHC is classified into classes I, II and III. class I and class II genes code for HLA (Human Leukocytic Antigen), which are transplantation antigens. HLA antigens are proteins responsible for discriminating self and non-self in the immune mechanism. Since a large number of alleles exist on their gene loci, the genes coding for these antigens are known to be highly polymorphic.

[0005] Determination of genotypes (typing) of HLA provides information for determination of the possibility of transplantation between immunogenetically different individuals. Specifically, this is employed for transplantation of an organ or tissue such as bone marrow, kidney, liver, pancreas, islets of Langerhans or cornea. The HLA genotypes are considered to be associated with certain refractory diseases and can also be utilized as supplementary means for diagnosing chronic rheumatoid arthritis, IDDM, insulin autoimmune syndrome and so forth. Besides, HLA typing is applied in a paternity test or individual identification because of the genetic polymorphism of HLA antigens.

[0006] 2. Genes Involved in HLA Typing and Polymorphism

[0007] Human MHC is an HLA gene complex located on the short arm of the 6th chromosome. HLA antigens encoded by these genes include class I antigens controlled by HLA-A, -B, -C loci and class II antigens controlled by the HLA-D region (DR, DQ and DP).

[0008] class I antigens have a double-stranded structure composed of L-chain called â2 microglobulin having a molecular weight of 12 kDa and H-chain having a molecular weight of 45 kDa. These antigens are involved in cellular immunity mediated by T cells, determine antigen specificity, and become target antigens in transplantation immunity. class II antigens have a double-stranded structure of two chains having molecular weights of 34 kDa and 29 kDa, respectively, determine antigen recognition and are involved in antigen presentation in humoral immunity. DP, DQ and DR in the HLA-D region are further subtyped according to polymorphism based on the amino acid or nucleotide sequence. DR is classified into about 20 subtypes, DQ is classified into about 10 subtypes, and DP is classified into a few subtypes. This large number of subtypes is attributed to the facts that the HLA antigens are composed of the á-chain and the â-chain each having a different molecular weight and that only the â-chain serves as an alloantigenic determinant except for the DQ antigens. Moreover, the subtypes are further subdivided based on the amino acid sequences or the corresponding nucleotide sequences of the antigenic determinants.

[0009] 3. Means for HLA Typing

[0010] Serological test utilizing antiserum reactions and cytological methods utilizing blast transformation of lymphocytes have been generally used. However, not only time and labor are required for examination and operation is complicated, but also accuracy of obtainable results are not so high. Therefore, DNA-based typing methods utilizing PCR are being developed to overcome these drawbacks and put into practical use. Examples thereof include the PCR-SSP method (2), PCR-RFLP method (3), PCR-SSOP method (4), PCR-SSCP method (5) and so forth.

[0011] In the PCR-SSP method, a gene sequence is confirmed by amplifying the hypervariable region of target HLA antigen to determine the HLA antigen type. In this method, a large number of specific primers must be prepared to enable high accuracy typing and an enormous number of times of PCR also must be performed. Thus, this method is not necessarily practical.

[0012] In the PCR-RFLP (PCR-restriction fragment length polymorphism) method, a nucleotide sequence is amplified by PCR so as to contain a region involved in HLA antigen typing and the obtained amplification product is digested with restriction enzymes. The nucleotide sequence of the amplification product is digested by using restriction enzymes cleaving different sites depending on the HLA type and separated by electrophoresis. Then, the type is determined based on the migration pattern. This method is characterized in that results can be rapidly obtained. However, the cleavage sites of the restriction enzymes may not necessarily exist in the sequence. Further, the amplification product must be digested with multiple kinds of restriction enzymes for one typing. Thus, this method is not practical to process a large amount of specimen.

[0013] In the PCR-SSOP (PCR-sequence specific oligonucleotide probe) method, a nylon membrane on which DNA amplified by primers specific to HLA gene is immobilized is prepared and respective HLA type specific oligonucleotide probes are hybridized for typing. In a modified method of PCR-SSOP, a membrane on which respective HLA type specific oligonucleotides are immobilized is prepared and DNA amplified by using HLA gene specific primers are hybridized. In the method of immobilizing amplified DNA, a membrane must be prepared for a probe of each type for hybridization and therefore much labor is required for multiple specimen typing. Since the substrate on which amplified DNA or oligonucleotides are immobilized is a membrane, a membrane having a large area must be prepared to perform high accuracy typing with one membrane. Therefore, the typing pattern may be complicated.

[0014] In the PCR-SSCP (PCR-single strand conformation polymorphism) method, DNA amplified by PCR is denatured to obtain single strands and changes in the high-order structure due to the difference in nucleotide sequences are detected by electrophoresis. In this method, all DNA of known types must be electrophoresed on the same gel. Thus, practical multiple specimen processing is almost impossible.

[0015] 4. Importance of High Accuracy HLA Typing

[0016] To achieve ideal transplantation, it is important that HLA types of donor and recipient are compatible with high accuracy. Therefore, a tissue or individual information typed in high accuracy must be clarified in advance. In this respect, HLA antigens of the donor and the recipient must be compared with all the types currently discovered for determination before transplantation. Even if no donor having completely compatible HLA types is found, a high success rate can be expected by performing transplantation between individuals having similar types of which high accuracy HLA types are determined. Further, it is also expected that load of recipient can also be relieved in immune responses such as a rejection reaction occurring after transplantation.

[0017] When high accuracy typing is carried out in personal identification, one completely compatible individual is found out of tens or hundreds of thousands of individuals, but such an individual can be identified in high accuracy. Furthermore, if high accuracy typing is performed for each gene locus of HLA antigens, the accuracy of the personal identification can be further improved.

[0018] In a medical scene requiring HLA type information or a situation requiring a personal identification, provision of highly reliable HLA type information is being required. It is important that typing of a large number of specimens can be easily and conveniently performed by HLA typing methods therefor. Currently, various methods are being developed and improved, but there remain many drawbacks that operation is complicated, multiple specimen processing is not possible and so forth.

DISCLOSURE OF THE INVENTION

[0019] To solve these problems, an object of the present invention is to provide a kit and method that are suitable for processing of a large number of specimens and enable a large number of high accuracy typing tests by one test for one specimen.

[0020] The present invention provides a typing kit for determining HLA genotype of a test specimen by hybridization between a nucleic acid sequence derived from the test specimen and oligonucleotides, which comprises a substrate on which the oligonucleotides are immobilized through covalent bonds, wherein the oligonucleotides are of 10-24 nucleotide length and are derived from sequences of a group of genes belonging to HLA class I or class II antigen on a human genome and each of the oligonucleotides includes polymorphism of each gene as alloantigen in the sequence.

[0021] The present invention also provides a method for determining HLA genotype of a test specimen, which comprises allowing hybridization of the oligonucleotides on the substrate of the aforementioned typing kit with a nucleic acid sequence derived from the specimen and detecting occurrence of hybridization of the oligonucleotides and the nucleic acid sequence derived from the specimen.

[0022] The present invention also provides the aforementioned typing kit, wherein class I antigen is an antigen controlled by a gene locus coding for any of HLA-A, HLA-B, HLA-C, HLA-D, HLA-E, HLA-F and HLA-G or a null gene and class II antigen is an antigen controlled by a gene locus coding for any of HLA-DQ, HLA-DR or HLA-DP or a pseudogene;

[0023] The aforementioned typing kit, wherein HLA-DQ is an antigen derived from any of DQA1, DQA2, DQB1 and DQB2 gene loci or a pseudogene;

[0024] the aforementioned typing kit, wherein HLA-DR is an antigen derived from any of DRA, DRB1, DRB3, DRB4 and DRB5 gene loci or a pseudogene; and

[0025] the aforementioned typing kit, wherein HLA-DP is an antigen derived from any of DPA1, DPA2, DPB1 and DPB2 gene loci or a pseudogene.

[0026] The present invention also provides an oligonucleotide, which comprises a nucleotide sequence based on any of the aforementioned oligonucleotides of 10-24 nucleotide length comprising a nucleotide sequence specific to each type of HLA gene sequences on the human genome and obtained by extending or shortening one of the oligonucleotides at 5′ or 3′ end or at both ends, and in which the sequence specific to each HLA type is not substituted.

[0027] The present invention also provides the aforementioned typing kit, wherein at least one of the aforementioned oligonucleotides is replaced with an oligonucleotide of 8-24 nucleotide length obtained by extending or shortening any of the nucleic acid sequences of SEQ ID NOS: 1-397, 456-503, 507-589, 594-898, 908-1072 or 1080-1298 for a gene sequence on the genome at 5′ or 3′ end or at both ends without eliminating or changing nucleotides associated with the gene polymorphism to have optimized binding affinity for the aforementioned hybridization.

[0028] The present invention further provides the aforementioned typing kit, wherein at least one of the oligonucleotides is an oligonucleotide whose binding affinity for the hybridization is reduced by replacing an arbitrary nucleotide not involved in the gene polymorphism with a spacer compound, for example, a spacer compound having a nucleic acid frame that does not form a hydrogen bond with any nucleotide.

[0029] Furthermore, peptide nucleic acids (PNA) can be used instead of these oligonucleotides.

[0030] The present invention further provides a method for determining HLA genotype of a specimen, which comprises a step of carrying out low accuracy typing of HLA genotype of the specimen by performing first PCR amplification using primers for low accuracy genotyping and a nucleic acid sequence derived from the. specimen as a template, allowing hybridization of the amplification product with oligonucleotides contained in the aforementioned typing kit, and detecting occurrence of hybridization of the nucleic acid sequence derived from the specimen and each of the oligonucleotides; and

[0031] a step of carrying out high accuracy HLA genotyping of the specimen by performing second PCR amplification based on the above determination result using primers appropriately selected from primers for high accuracy genotyping and a nucleic acid sequence derived from the specimen as a template, allowing hybridization of the amplification product with the oligonucleotides contained in the aforementioned typing kit, and detecting occurrence of hybridization of the nucleic acid sequence derived from the specimen and each of the oligonucleotides.

[0032] The present invention provides primers for low accuracy typing used for preparation of a probe for low accuracy typing, which consist of any oligonucleotide pair or an arbitrary combination of oligonucleotide pairs selected from a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 398 and 400 for amplifying DQB1;

[0033] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 399 and 400 for amplifying DQB1;

[0034] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 401 and 403 for amplifying DRB1; and

[0035] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 402 and 403 for amplifying DRB1.

[0036] The present invention further provides primers for high accuracy typing used for preparation of a probe for high accuracy typing based on result of low accuracy typing, which consist of any oligonucleotides pair or an arbitrary combination of oligonucleotides pairs selected from:

[0037] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 404 and 405 for amplifying DQB1;

[0038] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 404 and 406 for amplifying DQB1;

[0039] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 407 and 409 for amplifying DQB1;

[0040] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 408 and 409 for amplifying DQB1;

[0041] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 410 and 412 for amplifying DQB1;

[0042] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 411 and 412 for amplifying DQB1;

[0043] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 413 and 417 for amplifying DRB1;

[0044] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 414 and 417 for amplifying DRB1;

[0045] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 415 and 417 for amplifying DRB1; and

[0046] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 416 and 417 for amplifying DRB1.

[0047] The present invention further provides primers for high accuracy typing used for preparation of a probe for high accuracy typing, which consist of any oligonucleotide pair or an arbitrary combination of oligonucleotides pair selected from:

[0048] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 418 and 420 for amplifying DQA1;

[0049] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 419 and 420 for amplifying DQA1;

[0050] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 421 and 422 for amplifying DQB1;

[0051] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 423 and 424 for amplifying DRA1;

[0052] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 425 and 428 for amplifying DRB1;

[0053] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 426 and 428 for amplifying DRB1;

[0054] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 427 and 428 for amplifying DRB1;

[0055] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 429 and 431 for amplifying DRB3;

[0056] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 430 and 431 for amplifying DRB3;

[0057] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 432 and 433 for amplifying DRB4;

[0058] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 434 and 435 for amplifying DRB4;

[0059] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 436 and 437 for amplifying DRB5;

[0060] a pair of oligonucleotides having nucleotide, sequences of SEQ ID NOS: 438 and 439 for amplifying DRB6;

[0061] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 438 and 440 for amplifying DRB6;

[0062] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 441 and 442 for amplifying DRB7;

[0063] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 443 and 444 for amplifying DPA1;

[0064] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 445 and 446 for amplifying DPB1; and

[0065] a pair of oligonucleotides having nucleotide sequences of SEQ ID NOS: 445 and 447 for amplifying DPB1.

[0066] The term “class” used for HLA classes I and II in the present specification means classification based on the roles played in an organism. That is, the present specification is also according to this classification. class I antigen is a generic designation of HLA-A, HLA-B, HLA-C, HLA-D, HLA-E, HLA-F and HLA-G antigens. class II antigen is a generic designation of HLA-DQ, HLA-DR and HLA-DP antigens. Alloantigens are antigens characterizing individuals that belong to the same animal species but have genetic differences. Genetic differences mean differences in nucleotide sequences. Further, each of alloantigens classified based on genetic differences is designated as an alloantigen type.

[0067] In the present specification, the term “polymorphism” means a characteristic of having the same function but a different primary structure in a protein or DNA coding therefor.

[0068] In the present specification, the term “gene locus” means a position occupied by each HLA gene having polymorphism on a chromosome. As for gene loci of DR, DQ and DP antigens, gene loci of the DR antigens include DRA, DRB1, DRB3, DRB4 and DRB5, gene loci of the DQ antigens include DQA1, DQA2, DQB1 and DQB2, and gene loci of the DP antigens include DPA1, DPA2, DPB1 and DPB2.

[0069] In the present specification, the term “antigen derived from a gene locus” means an antigen translated from a gene present on the gene locus.

[0070] In the present specification, the term “nucleotides involved in gene polymorphism” means nucleotides having different primary sequences in genes coding for each alloantigen.

[0071] In the present specification, the term “test specimen” means a sample to be typed. In the present specification, it means chromosome DNA or RNA extracted from a tissue or somatic cell or a reactant enzymatically produced by using any of these as a template.

[0072] In the present specification, the term “homopolymer of thymidine residue” means a polymer obtained by repeatedly synthesizing deoxythymidine at 5′ or 3′ end of nucleotide sequence portion involved in typing. This synthesis of oligonucleotide can be performed by a commercially available DNA synthesizer.

[0073] Hereafter, a constitution of the kit of the present invention and a method of manufacturing the same, HLA typing method using the kit of the present invention, oligonucleotides for use in these kit and methods, a nucleic acid target derived from a test specimen human genome, which is a sample for use in the HLA typing using the kit of the present invention, and a method of manufacturing the same and primers for preparing the nucleic acid target will be explained.

[0074] <1> Synthetic Oligonucleotide for Use in the Present Invention

[0075] The synthetic oligonucleotides for use in the present invention are derived from human genomic genes involved in HLA typing and synthesized based on nucleotide sequences obtained from these genes. Hereafter, these oligonucleotides are also referred to as capture oligos.

[0076] Capture oligos are designed so that they should contain a type-specific nucleotide sequence region present in HLA gene of each type. The essential characteristic of the present invention is that the HLA typing is performed by identifying whether a test human genome has these regions.

[0077] Typing of a type-specific nucleotide sequence in genes involved in HLA typing can be carried out by allowing hybridization of each type-specific capture oligo with a nucleic acid fragment target (also referred to as “nucleic acid target”) having a part of nucleotide sequence of the genes involved in HLA typing of human chromosome DNA and determining with which capture oligo the fragment hybridizes.

[0078] The capture oligos can be prepared as synthetic oligonucleotides having a nucleotide sequence consisting of 10-24 nucleotides containing a nucleotide sequence specific to each type in a nucleotide sequence of gene involved in HLA typing. It is generally preferred that the capture oligos are designed so that the type-specific nucleotide sequence should be positioned in the center portions of the capture oligos. If the capture oligos are too short, it becomes difficult to detect hybridization. On the other hand, if the capture oligo is too long, inhibition of hybridization by a type-specific sequence does not occur. Therefore, the range of 10-24 nucleotides is preferred. However, this optimization of the capture oligo length primarily depends on characteristics of the sequence (content of specific nucleotide and repetition of the same nucleotide), and it has been confirmed by experiments according to the present invention that even a short chain can be used so long as it shows good binding property. In the process of hybrid formation of a capture oligo and a target, if there is an obstruction in the secondary structure negatively affecting the hybridization, a spacer or a nucleotide forming no hydrogen bond with any nucleotide can be introduced into the oligonucleotide sequence to obviate the obstruction. Further, the obstruction in the secondary structures of the target and capture oligo can also be obviated by extending or shortening the gene sequence on genome corresponding to the capture oligo at 5′ or 3′ end or at both ends of the capture oligo so that a type-specific sequence portion should be included.

[0079] DNA is usually used as the capture oligos, but a peptide nucleic acid (PNA) may also be used. The hybrids of a nucleic acid derived from a test human genome with a peptide nucleic acid have a higher Tm (melting temperature) compared with those of oligonucleotides and therefore they are expected to provide stable hybridization signals. The peptide nucleic acids can be readily synthesized by using a common peptide synthesizer.

[0080] Examples of capture oligo nucleotide sequences are shown as SEQ ID NOS: 1-397, 456-503, 507-589, 594-898, 908-1078 and 1080-1298. These capture oligos are designed based on nucleotide sequence data obtained from publications and the home page of the Japanese Society for Histocompatibility and Immunogenetics (http://square.umin.ac.jp/JSHI/frame.html) and cover the whole HLA types.

[0081] Typing of a specific HLA type can be carried out by appropriately selecting a capture oligo from them and using it in a test.

[0082] The capture oligo length is, in general, in a range of 14-22 nucleotides. From the viewpoint of hybridization, 16-17 nucleotides is a typical size. Besides the nucleotide sequences of SEQ ID NOS: 1-397, oligonucleotides having a nucleotide sequence obtained by extending or shortening any of the HLA type gene sequences at 5′ or 3′ end or at both ends of the nucleotide sequences can be used as a capture oligo.

[0083] The nucleotide sequences of SEQ ID NOS: 1-397, 456-503, 507-589, 594-898, 908-1078 and 1080-1298 may also be extended at either 5′ or 3′ end and shortened at the other end, but the length of a capture oligo is in a range of 10-24 nucleotides in any case.

[0084] In the present invention, the designed capture oligos well reflect the results of studies and researches before the present application. However, when additional information about nucleotide sequnences of novel HLA types is obtained thereafter, novel capture oligos will be designed based on the method described in the present specification and they will fall within the claimed scope of the present application.

[0085] Synthesis of oligonucleotides, preparation of chromosome DNA, hybridization and PCR can be performed by usual methods known to those skilled in the art (see Maniatis, T. et al., “Molecular Cloning, A Laboratory Manual, second edition”, Cold Spring Harbor Laboratory Press (1989)). The oligonucleotides can also be synthesized by using a commercially available DNA synthesizer.

[0086] <2> Preparation of Substrate for Use in Present Invention

[0087] Material of a substrate on which oligonucleotides are immobilized is not particularly limited so long as the oligonucleotides can be stably immobilized. For example, there can be mentioned glass, synthetic resins such as polycarbonates and plastics. The form of the substrate is not particularly limited, but there can be mentioned a form of plate or film. A uniform and flat surface is suitable as a surface of the substrate.

[0088] The oligonucleotides can be immobilized on a substrate by using a method employed in usual hybridization such as physical absorption, electric bond and molecular covalent bond. In the examples of the present specification, substrates coated with carbodiimide groups or isocyanate groups on the surface thereof (Japanese Patent Laid-Open (Kokai) No. 08-023975) were used. To prepare the substrates coated with a material having carbodiimide groups or isocyanate groups on the surface thereof, employed was a method in which the substrate surfaces were coated with a polymer compound containing carbodiimide groups or isocyanate groups and irradiated with ultraviolet ray so that oligonucleotides can be covalently bonded and immobilized thereon. This is because marked improvement of immobilization efficiency was successfully attained by irradiating a substrate having carbodiimide groups or isocyanate groups on the surface thereof with ultraviolet ray. As a linker for binding carbodiimide group or isocyanate group and an oligonucleotide, a compound having an amino group or imino group highly reactive to the carbodiimide group or isocyanate group is used. In case of the imino group, carbodiimide group or isocyanate group can be bound by polymerizing thymine at either end of the capture oligo.

[0089] When oligonucleotides are spotted, if the amount of spotted oligonucleotides is too small, sufficient reactivity between the oligonucleotides and the nucleic acid target may not be ensured and therefore typing may become difficult. Further, high-density spotting invites technical problems as well as high cost. In addition, a more precise and expensive detecting device (typically, a scanner) is required for determination of occurrence of hybridization utilizing fluorescent labeling of the nucleic acid target, chemical color development or the like. Therefore, the oligonucleotides are preferably immobilized on the substrate surface in a diameter of 10-1,000 μm. The oligonucleotides can be immobilized by spotting an oligonucleotide solution on a substrate by using, for example, a spotting machine. It is usually preferable that the oligonucleotide solution is spotted substantially in a circular shape.

[0090] Each oligonucleotide is spotted at a plurality of sites on one single substrate, and the spots are preferably arranged in a grid pattern. When the spot size is 1000 μm in diameter, the total number of the spots is preferably 1600 or less per cm2, and when such spots are spotted in a square shape, the square dimension is preferably 40×40 or less. When the spot size is 10 μm in diameter, the total number of spots is preferably 400 or less per cm2 , and when such spots are spotted in a square shape, the square dimension is preferably 20×20 or less. If the longitudinal and transverse sizes are different, the numbers along longitudinal and transverse directions can be adjusted depending on the shape.

[0091] <3> Arrangement of Oligonucleotides on Substrate

[0092] To facilitate typing of each HLA type, oligonucleotides are preferably arranged on a substrate so that oligonucleotides to be used for determining each HLA type should be placed in one partition, in a line, or the like. Oligonucleotides suitable for low accuracy genotyping and those suitable for high accuracy genotyping may be immobilized on the same substrate to simultaneously carry out low accuracy genotyping and high accuracy genotyping. To perform low accuracy genotyping and high accuracy genotyping stepwise, a substrate on which oligonucleotides suitable for low accuracy genotyping are immobilized and a substrate on which oligonucleotides suitable for high accuracy genotyping are immobilized may be separately prepared.

[0093] Alternatively, the typing may be performed by preparing alignment of gene sequence of each HLA, setting a nucleotide sequence in which at least two nucleotide polymorphisms or sequence polymorphisms involving the HLA typing are observed in a nucleotide sequence consisting of 1-10 nucleotides as a patchwork segment, and finding the patchworks in gene sequences of all of the HLA genes and, performing typing by combination of the patchworks. To perform advanced typing, the typing may be performed by setting a nucleotide sequence in which at least one nucleotide polymorphism or sequence polymorphism are observed in a nucleotide sequence consisting of 1-10 nucleotides based on the alignment of the nucleotide sequences of HLA genes as a satellite segment, and finding the satellites in gene sequences of all of the HLA genes and, performing typing by combination of the satellites, whereby a type which cannot be discriminated by the patchworks may be discriminated. Typing using patchworks and satellites may make it possible to judge whether each of HLA typing of the test specimen is homozygote or heterozygote and determine the types of HLA simultaneously. The oligonucleotides may be prepared to be allocated so that the HLA types are determined by developing progressively the patchworks and satellites in a test specimen.

[0094] Spots on the substrate are usually arranged within an area of 1 cm2. FIGS. 1-7 and 11-17 show examples of preferred positions of oligonucleotides immobilized on the substrate. One square in the figure represents a spot of each oligonucleotide. The indicated numbers represent sequence numbers of the oligonucleotides.

[0095] <4> Preparation of Nucleic Acid from Test Sample and Preparation of Nucleic Acid Probe

[0096] Nucleic acid can be prepared from a test sample by the same way as a usual method of preparing nucleic acids from animal cells. For example, DNA can be prepared by a method described in Maniatis, T. et al., “Molecular Cloning, A Laboratory Manual, second edition”, Cold Spring Harbor Laboratory Press (1989). DNA can also be extracted from cells obtained by culture in a similar manner. This method is a standard test method, but there are many alternative methods and any of these methods may be employed.

[0097] A nucleic acid target for use in HLA typing is prepared by using the obtained DNA. The nucleic acid target can be prepared by amplifying a nucleic acid by using primers designed so as to correspond to a nucleotide sequence of capture oligo. While DNA is usually used as the nucleic acid target, RNA may also be used. As a nucleic acid amplification method, there can be mentioned, for example, a method of amplifying the nucleic acid as DNA by PCR (polymerize chain reaction) or as RNA by in vitro transcription.

[0098] Primers used for PCR are designed so that a nucleic acid target should include a complementary nucleotide sequence of a capture oligo except for a sequence region specific to each HLA type. A nucleic acid target may be longer or shorter than a capture oligo, so long as it is capable of hybridization. To increase specificity of amplification reactions, initial amplification may be carried out by using preliminary primers for amplifying a region larger than the target nucleic acid probe and then nucleic acid amplification may be carried out by using the amplified DNA as a template and primers for obtaining the target nucleic acid probe.

[0099] There may be a plurality of type-specific nucleotide sequence regions involved in typing depending on HLA types. In such a case, nucleic acid targets corresponding to each specific region can be prepared.

[0100] Furthermore, typing of DQB and DRB is carried out by selecting primers for high accuracy typing based on results obtained by using a nucleic acid sequence amplified by primers for low accuracy typing and then carrying out high accuracy typing, or allowing hybridization of nucleic acid sequences amplified by using all of the low accuracy primers for DQB and DRB and nucleic acid sequences amplified by using all of the high accuracy primers for DQB and DRB in separate blocks on which different captures are immobilized and determining low accuracy or high accuracy type from the obtained respective results. For typing of DQA, DRA, DPA and DPB, high accuracy typing is performed by using nucleic acid sequences amplified by using primers for high accuracy typing.

[0101] If a primer for use in final nucleic acid amplification is labeled in advance, a labeled nucleic acid target can be obtained. The nucleic acid target may be labeled during or after nucleic acid amplification. As the label, those labeling substances similar to those for a probe for use in usual hybridization, such as fluorescent substances or haptens, can be used. Specifically, as the fluorescent substances, there can be mentioned, for example, fluoresceine (FITC), rhodamine, phycoerythrin (PE), Texas Red, cyanine fluorescent dyes and so forth. As the haptens, there can be mentioned biotin, digoxigenin (Dig), dinitrophenyl (DNP) and so forth.

[0102] Primers for preparing a nucleic acid target can be included in an HLA typing kit together with a substrate on which oligonucleotides are immobilized.

[0103] <5> Hybridization of Oligonucleotides on Substrate and Nucleic Acid Target

[0104] Hybridization can be performed in the same way as usual nucleic acid hybridization. A specific procedure will be exemplified below.

[0105] A nucleic acid target is added to a fusion solution comprising a salt solution such as standard saline citrate (SSC), a blocking solution such as sodium dodecyl sulfate (SDS) or bovine serum albumin (BSA) and an additive for promoting fusion reactions. When the target is double-stranded, denaturation is performed by heating or the like. After a few μL of a nucleic acid target solution is added onto a substrate, heat treatment is performed for a few hours (usually at 37-70° C.) so that a hybrid should be formed between an oligonucleotide immobilized on the substrate and the nucleic acid target.

[0106] 5× SSC or 3 M tetramethylammonium chloride is added onto the substrate and heated (usually at 37-50° C.). Then, nonspecific nucleic acids that do not form hybrids are removed from the substrate and only specific hybrids are selectively maintained on the substrate.

[0107] To detect a hybrid, a fluorescent substance or hapten introduced into the nucleic acid target is used. When a hapten is used, a solution containing a conjugate of a protein recognizing the hapten or a protein that binds to the hapten and alkaline phosphatase, horseradish peroxidase or the like (enzyme conjugate) is added onto the substrate and allowed to react at room temperature for several tens of minutes. A nonspecific adsorption reaction of the enzyme conjugate and the substrate can be prevented by completely coating regions on the substrate other than the regions on which oligonucleotides are immobilized with a protein such as casein before this binding reaction of the hapten and the enzyme conjugate is performed. This treatment can be carried out by, after the oligonucleotides are immobilized, adding a solution of a protein such as casein onto the substrate and leaving it at room temperature for a several tens of minutes.

[0108] After the binding reaction of the enzyme conjugate and the hapten of the nucleic acid target is completed, the substrate is washed with an appropriate buffer containing a surfactant to remove enzyme conjugates that have not bound to the hapten. Thus, only enzyme conjugates bound to the hapten in the nucleic acid target should remain on the substrate.

[0109] To visualize the hybrid, a compound that becomes insoluble only in the presence of a hapten and an enzyme conjugate is added. The generation of such an insoluble compound is amplified by enzymatic reaction, and hence the hybrid is visualized. As the compound used for this purpose, when the enzyme in the enzyme conjugate is alkaline phosphatase, there can be used nitroblue tetrazolium chloride (NBT) and 5-bromo-4-chloro-3-indolylphosphate p-toluidine salt (BCIP). When the enzyme is horseradish peroxidase, 3,3′,5,5′-tetramethylbenzidine (TMB) or the like can be used.

[0110] HLA typing based on the obtained results of hybridization is carried out by observing pigmentation or fluorescence at positions where capture oligos are immobilized. That is, the positions showing pigmentation or fluorescence indicate a corresponding gene. When all of oligonucleotides belonging to each type show color development, the type is determined. For example, in FIGS. 8-10 referred to in the examples, hybridization signals were obtained only for oligonucleotides of SEQ ID NOS: 141 and 143 out of SEQ ID NOS: 141-144, and thus the test specimen is typed as DRA*0101. Correspondence of hybridization signals obtained at positions of capture oligos of SEQ ID NOS: 1-397 and HLA types are summarized in Tables 1-20.

1TABLE 1Correspondence of DQA1 types and high accuracy typing capture oligosTypeCorresponding capture oligosDQA1*01011, 4, 7, 10, 12, 14, 16, 18, 22, 24, 27, 31, 35, 39, 42, 47, 51, 53DQA1*010211, 4, 7, 10, 12, 14, 16, 22, 24, 27, 31, 35, 39, 42, 47, 51, 53DQA1*010221, 4, 7, 10, 12, 14, 16, 20, 22, 24, 2731, 35, 39, 42, 47, 51, 53DQA1*01032, 4, 7, 10, 15, 20, 22, 26, 27, 31, 35, 39, 42, 47, 51, 53DQA1*01041, 4, 7, 10, 12, 14, 16, 18, 22, 24, 27, 31, 35, 39, 42, 47, 51, 53DQA1*01051, 4, 7, 10, 12, 14, 16, 18, 22, 24, 27, 31, 35, 39, 42, 47, 51, 53DQA1*02011, 5, 8, 10, 15, 19, 23, 24, 28, 32, 37, 39, 42, 47, 52, 53DQA1*030112, 5, 9, 13, 17, 19, 23, 24, 29, 33, 37, 41, 43, 48, 49, 52, 53DQA1*03022, 5, 9, 13, 17, 19, 23, 24, 29, 33, 36, 41, 43, 49, 52, 53DQA1*03031, 5, 9, 12, 17, 19, 23, 24, 29, 33, 36, 41, 43, 49, 52, 53DQA1*04012, 6, 8, 10, 12, 14, 16, 21, 22, 25, 30, 34, 38, 41, 44, 48, 52, 54DQA1*050113, 6, 8, 10, 12, 14, 16, 21, 22, 25, 30, 34, 38, 41, 45, 50, 52, 53DQA1*050121, 6, 8, 10, 12, 14, 16, 20, 22, 25, 30, 34, 38, 41, 45, 50, 52, 53DQA1*050133, 6, 8, 10, 12, 14, 16, 20, 22, 25, 30, 34, 38, 41, 45, 50, 52, 53DQA1*05028, 10, 12, 14, 16, 20, 22, 25, 30, 34, 38, 40, 45, 50, 52, 53DQA1*05033, 6, 8, 10, 12, 14, 16, 20, 22, 25, 30, 34, 38, 41, 45, 50, 52, 53DQA1*05043, 6, 8, 11, 14, 16, 20, 22, 25, 30, 34, 38, 41, 45, 50, 52, 53DQA1*060112, 6, 8, 10, 15, 21, 22, 25, 30, 34, 38, 41, 46, 48, 52, 53DQA1*060128, 10, 15, 21, 22, 25, 30, 34, 38, 41, 46, 48, 52, 53

[0111]

2

TABLE 2

Correspondence of DQB types and low

accuracy typing capture oligos

Corresponding

Type
capture oligos

DQB1*0501
56

DQB1*0502
56

DQB1*05031
56

DQB1*06011
55

DQB1*06013
55

DQB1*0602
55

DQB1*0603
55

DQB1*0604
56

DQB1*06051
56

DQB1*0609
56

DQB1*0610
55

DQB1*0611
55

DQB1*0612
56

DQB1*0614
55

DQB1*0201
57, 58

DQB1*0202
57, 58

DQB1*0203
57, 58

DQB1*03011
57

DQB1*03012
57

DQB1*0302
57

DQB1*03032
57

DQB1*0304
57

DQB1*0305
57

DQB1*0306
57

DQB1*0307
57

DQB1*0308
57

DQB1*0401
57

[0112]

3

TABLE 3

Correspondence of DQB types and high accuracy typing capture oligos

Type
Corresponding capture oligos

DQB1*0501
62, 65, 68, 70, 74, 79, 82, 86, 89, 92, 97, 99, 103, 114, 116, 118, 126, 131, 137, 138

DQB1*0502
62, 65, 68, 70, 74, 79, 82, 86, 89, 93, 97, 99, 104, 114, 116, 118, 126, 130, 137, 138

DQB1*05031
62, 65, 68, 70, 74, 79, 82, 86, 94, 97, 99, 106, 114, 116, 118, 126, 130, 137, 138

DQB1*05032
74, 79, 82, 86, 94, 97, 99, 105, 114, 116

DQB1*0504
65, 68, 70, 74, 80, 83, 86, 89, 93, 97, 99, 104, 114, 117, 119, 126, 131

DQB1*06011
63, 66, 69, 75, 80, 84, 94, 97, 99, 106, 114, 117, 120, 124, 127, 132, 135, 139

DQB1*06012
66, 68, 70, 75, 80, 84, 94, 98, 99, 106, 114, 117, 120, 124, 127, 132, 135, 139

DQB1*06013
63, 66, 69, 75, 80, 84, 94, 97, 99, 106, 114, 117, 120, 124, 127, 132, 135, 139

DQB1*0602
64, 67, 68, 70, 76, 80, 87, 89, 95, 97, 99, 105, 114, 116, 121, 125, 127, 132, 135, 139

DQB1*0603
62, 67, 68, 70, 77, 79, 87, 89, 95, 97, 99, 105, 114, 116, 121, 125, 127, 132, 135, 139

DQB1*0604
62, 67, 68, 70, 77, 79, 87, 89, 93, 97, 99, 103, 114, 116, 122, 125, 127, 132, 134, 138

DQB1*06051
62, 65, 68, 70, 77, 8087, 89, 93, 97, 99, 103, 114, 116, 122, 125, 127, 132, 134, 138

DQB1*06052
77, 80, 87, 89, 93, 97, 99107, 114, 116, 122, 125, 127, 132

DQB1*0606
77, 80, 87, 89, 93, 97, 99, 103, 114, 116, 122, 128, 129, 131

DQB1*0607
67, 68, 70, 77, 79, 87, 89, 95, 97, 99, 105, 114, 116, 122, 125, 127, 132

DQB1*0608
67, 68, 70, 77, 79, 87, 89, 95, 97, 99, 103, 114, 116, 121, 127, 132

DQB1*0609
62, 67, 68, 7077, 80, 87, 89, 93, 97, 99, 103, 114, 116, 122, 125, 127, 132, 134, 138

DQB1*0610
64, 67, 68, 70, 76, 80, 87, 89, 95, 97, 99, 104, 114, 116, 121, 125, 127, 132, 135, 139

DQB1*0611
67, 68, 70, 76, 80, 87, 89, 95, 97, 99, 105, 114, 116, 121, 125, 127, 132, 135, 139

DQB1*0612
62, 67, 68, 70, 77, 80, 87, 89, 93, 97, 99, 103, 114, 116, 121, 125, 127, 132, 134, 138

DQB1*0613
64, 67, 68, 70, 76, 80, 87, 89, 95, 97, 99, 103, 114, 116, 121, 125, 127, 132, 135

DQB1*0614
67, 68, 70, 77, 79, 87, 89, 95, 97, 99, 105, 114, 116, 121, 125, 127, 132, 135, 139

DQB1*0201
60, 61, 62, 67, 71, 78, 81, 85, 90, 100, 108, 114, 116, 123, 128, 129, 131, 136, 140

DQB1*0202
59, 60, 61, 62, 67, 71, 78, 81, 85, 90, 100, 108, 114, 117, 123, 128, 129, 131, 136, 140

DQB1*0203
62, 67, 71, 78, 81, 85, 90, 100, 109, 114, 116, 117, 123, 128, 129, 131, 136, 140

DQB1*03011
62, 66, 68, 70, 75, 80, 88, 91, 93, 101, 110, 114, 116, 122, 125, 127, 132, 136, 140

DQB1*03012
66, 68, 70, 75, 80, 87, 91, 93, 101, 110, 114, 116, 122, 125, 127, 132, 136, 140

DQB1*0302
62, 67, 68, 70, 76, 80, 88, 94, 101, 111, 114, 116, 122, 125, 127, 132, 136, 140

DQB1*03032
62, 67, 68, 70, 76, 80, 88, 94, 101, 110, 114, 116, 122, 125, 127, 132, 136, 140

DQB1*0304
62, 66, 68, 70, 75, 80, 88, 91, 93, 101, 111, 114, 116, 122, 125, 127, 132, 136, 140

DQB1*0305
62, 67, 72, 74, 80, 87, 94, 101, 111, 114, 116, 122, 125, 127, 132, 136, 140

DQB1*0306
62, 67, 68, 70, 76, 80, 88, 94, 101, 110, 115, 117, 119, 126, 133, 136, 140

DQB1*0307
62, 67, 68, 70, 76, 80, 88, 96, 101, 111, 114, 116, 122, 125, 127, 132, 136, 140

DQB1*0308
62, 67, 68, 70, 76, 80, 88, 94, 101, 111, 114, 116, 121, 125, 127, 132, 136, 140

DQB1*0401
64, 67, 73, 74, 80, 87, 94, 102, 112, 113, 115, 117, 119, 126, 133, 136, 140

DQB1*0402
64, 67, 72, 74, 80, 87, 94, 102, 112, 113, 115, 117, 119, 126, 133, 136, 140

[0113]

4

TABLE 4

Correspondence of DRA types and high

accuracy typing capture oligos

Corresponding

Type
capture oligos

DRA*0101
141, 143

DRA*0102
142, 144

[0114]

5

TABLE 5

Correspondence of DRB1 types and low accuracy

and high accuracy typing capture oligos (1), alleles

whose serological antigen type is DR1

Corresponding capture oligos

Type
low accuracy
High accuracy

DRB1*0101
145
166, 173, 187, 213, 246, 250

DRB1*01021
145
166, 173, 187, 213, 232, 236, 250

DRB1*01022
145
166, 173, 187, 213, 228, 232, 236, 250

DRB1*0103
145
166, 173, 187, 211, 215, 246, 250

DRB1*0104
145
173, 187, 213, 230, 250

DRB1*0105
145
173, 187, 192, 213, 246, 250

DRB1*0106
145

[0115]

6

TABLE 6

Correspondence of DRB1 types and low accuracy and high accuracy typing

capture oligos (2), alleles whose serological antigen type is DR2

Corresponding capture oligos

Type
low accuracy
high accuracy

DRB1*15011
149
157, 187, 194, 201, 211, 212, 234, 247

DRB1*15012
149
157, 187, 194, 201, 211, 212, 233, 247

DRB1*15021
149
157, 18, 7194, 201, 211, 212, 246, 247

DRB1*15022

187, 194, 211, 212, 247, 250

DRB1*15023
149
157, 181, 187, 194, 201, 211, 212

DRB1*1503
149
157, 178, 187, 194, 201, 211, 212, 234, 247

DRB1*1504
149
157, 187, 194, 201, 210, 212, 234, 247

DRB1*1505
149
157, 187, 194, 201, 212, 234, 247

DRB1*1506
149
187, 194, 196 201, 211, 212, 247

DRB1*1507
149
157, 187, 201, 211, 212, 247

DRB1*1508
149
157, 187, 194 201 212, 246, 247

DRB1*1509
149

DRB1*1510
149

DRB1*16011
149
157, 187 201, 210 220, 246, 247

DRB1*16012
149
157, 187, 20, 210, 246, 247

DRB1*16021
149
157, 187, 201, 220, 246, 247

DRB1*16022
149
187, 201, 247

DRB1*1603
149
157, 187 201, 210, 221, 246, 247

DRB1*1604
149
187, 201, 210, 222, 247

DRB1*1605
149
187, 201, 211, 220, 247

DRB1*1607
149
157, 187, 201, 211, 220, 241, 246, 247

DRB1*1608
149
157, 184 201, 210, 220, 246, 247

[0116]

7

TABLE 7

Correspondence of DRB1 Types and low accuracy and high accuracy typing

capture oligos (3), alleles whose serological antigen type is DR3

Corresponding capture oligos

low

Type
accuracy
high accuracy

DRB1*03011
146
171, 179, 184, 194, 216, 226, 229, 234, 229, 234, 248, 250

DRB1*03012
146
171, 179, 184, 194, 216, 226, 230, 234, 230, 234, 248, 250

DRB1*03021
146
174, 184, 216 226, 229, 246, 248, 250

DRB1*03022
146
174, 184, 216, 226, 230, 246, 248, 250

DRB1*0303
146
174, 184, 216, 226, 229, 234, 248, 250

DRB1*0304
146
171, 179, 187, 194, 216, 226, 229, 248, 250

DRB1*0305
146
171, 179, 184, 194, 216, 226, 229, 246, 248, 250

DRB1*0306
146
171, 179, 184, 216, 229, 234, 248, 250

DRB1*0307
146
179, 184, 194, 216, 226, 229, 234, 248, 250

DRB1*0308
146
171, 179, 184, 194, 206, 216, 226, 229, 234, 248

DRB1*0309
146
171, 182, 184, 194, 216, 226. 229, 246, 250

DRB1*0310
146
171, 179, 184, 194, 200, 216, 226, 229, 234, 244, 248

DRB1*0311
146
171, 179, 184, 194, 216, 227, 229, 234, 248, 250

DRB1*0312
146
171, 179, 184, 194, 199, 216, 226, 229, 248

DRB1*0313
146

DRB1*0314
146

DRB1*0315
146

DRB1*0316
146

DRB1*0317
146

[0117]

8

TABLE 8

Correspondence of DRB1 types and low accuracy and high accuracy typing

capture oligos (4), alleles whose serological antigen type is DR4

Corresponding capture oligos

Type
low accuracy
high accuracy

DRB1*04011
147
160, 169, 180, 216, 246, 249, 250

DRB1*04012
147
160, 169, 183, 216, 246, 249, 250

DRB1*0402
147
160, 169, 180, 211, 215, 234, 249, 250

DRB1*0403

160, 169, 180, 213, 223, 234, 249, 250

DRB1*04031
147

DRB1*04032
147
161, 169, 180, 201, 213, 223, 234, 249

DRB1*0404
147
160, 169, 180, 213, 234, 249, 250

DRB1*04051
147
160, 169, 180, 199, 213, 246, 249

DRB1*04052
147
160, 169, 180, 193, 199, 213, 246

DRB1*0406
147
160, 169, 180, 187, 213, 223, 234, 250

DRB1*0407
147
160, 169, 180, 213, 223, 246, 249, 250

DRB1*0408
147
160, 169, 180, 213, 246, 249, 250

DRB1*0409

169, 180, 199, 216, 249

DRB1*0410
147
160, 169, 180, 199, 213, 234, 249

DRB1*0411
147
160, 169, 180, 199, 213, 223, 234, 249

DRB1*0412
147
160, 169, 199, 211, 222, 234, 249

DRB1*0413

169, 180, 216, 234, 249, 250

DRB1*0414

169, 180, 211, 215, 249, 250

DRB1*0415
147
160, 169, 180, 206, 210, 249

DRB1*0416

169, 180, 207, 216, 249

DRB1*0417

169, 180, 199, 213, 223, 249

DRB1*0418

180, 211, 222, 234, 249, 250

DRB1*0419

169, 180, 187, 213, 246, 250

DRB1*0420

169, 180, 187, 213, 223, 250

DRB1*0421
147
160, 169, 180, 187, 216, 246, 250

DRB1*0422
147
160, 169, 180, 216, 226, 229, 234, 249, 250

DRB1*0423
147
160, 169, 180, 213, 245, 249, 250

DRB1*0424
147
160, 169, 180, 199, 214, 246, 249

DRB1*0425
147
160, 169, 180, 210, 222, 249, 250

DRB1*0426
147
160, 169, 180, 209, 216, 249

DRB1*0427
147
160, 169, 118, 213, 223, 236, 249, 250

DRB1*0428
147
160, 169, 180, 194, 199, 213, 246, 249

DRB1*0429
147
160, 169, 180, 197, 199, 213, 246, 249

DRB1*0430
147
160, 169, 180, 195, 213, 246, 249

DRB1*0431
147
160, 169, 180, 213, 222, 246, 249, 250

DRB1*0432
147
160, 169, 180, 219, 249, 250

DRB1*0433
147

DRB1*0434
147

[0118]

9

TABLE 9

Correspondence of DRB1 types and low accuracy and high

accuracy typing capture oligos (5), alleles whose serological

antigen type is DR5 and whose subtype is DR11

Corresponding capture oligos

Type
low accuracy
high accuracy

DRB1*11011
146
194, 206, 210, 246, 249

DRB1*11012
146
194, 206, 210, 239, 246, 249

DRB1*11013
146
194, 206, 210, 220, 246, 249

DRB1*1102
146
194, 206, 211, 215, 234, 249

DRB1*1103
146
194, 206, 210, 220, 246, 249

DRB1*11041
146
194, 206, 210, 234, 249

DRB1*11042
146
194, 206, 210, 234, 239, 249

DRB1*1105
146
194, 206, 210, 246, 249

DRB1*1106
146
194, 206, 210, 236, 249

DRB1*1107
146
194, 206, 216, 226, 229, 234, 249

DRB1*11081

194, 206, 246, 249

DRB1*11082

194, 206, 246, 249

DRB1*1109

179, 184, 194, 206, 210, 246, 248

DRB1*1110

179, 188, 194, 206, 210, 248

DRB1*1111

194, 206, 210, 215, 246, 249

DRB1*1112

188, 194, 206, 210

DRB1*1113
146
179, 188, 194, 206, 214, 232, 234, 248

DRB1*1114
146
194, 206, 211, 215, 246, 249

DRB1*1115
146
186, 194, 206, 210, 246

DRB1*1116
146
179, 184, 194, 206, 211, 215, 248

DRB1*1117
146
179, 188, 206, 214, 223, 232, 234, 248

DRB1*1118
146
194, 206, 211, 234, 249

DRB1*1119
146
194, 206, 211, 246, 249

DRB1*1120
146
179, 184, 194, 206, 211, 215, 246, 248

DRB1*1121
146
194, 206, 211, 215, 249

DRB1*1122
147
162, 194, 206 210, 246, 247, 249

DRB1*1123
146
194, 206, 210, 222, 249

DRB1*1124
146
185, 194, 206, 210

DRB1*1125
146
194, 206, 210, 222, 234, 249

DRB1*1126
146
194, 206, 213, 234, 249

DRB1*1127

194, 206, 210, 230, 249

DRB1*11271
146

DRB1*11272
146

DRB1*1128
146
184, 194 206

DRB1*1129
146
187, 194, 206, 210, 246

DRB1*1130
154
165, 194, 206, 210, 246, 249

DRB1*1131
146
194, 208, 211, 246, 249

DRB1*1132
146
194, 206, 210, 224, 246, 249

DRB1*1133
146
194, 210, 242, 246, 249, 250

DRB1*1134
146
194, 206, 213, 234, 249

DRB1*1135
146
194, 210, 234, 242, 249, 250

DRB1*1136
146

DRB1*1137
146

[0119]

10

TABLE 10

Correspondence of DRB1 types and low accuracy and high

accuracy typing capture oligos (6), alleles whose serological

antigen type is DR5 and whose subtype is DR12

Corresponding capture oligos

Type
low accuracy
high accuracy

DRB1*1201
146
158, 172, 191, 194, 202, 211, 220, 232, 236, 248

DRB1*12021
146
158, 172, 191, 194, 202, 210, 220, 232, 246, 248

DRB1*12022
146
158, 172, 191, 194, 202, 210, 220, 248

DRB1*12032
146
158, 172, 191, 194, 202, 211, 220, 234, 248

DRB1*1204
146
158, 172, 191, 194, 206, 211, 220, 232, 248

DRB1*1205
146
158, 172, 190, 194, 202, 211, 220, 232, 236, 248

DRB1*1206
146

[0120]

11

TABLE 11

Correspondence of DRB1 types and low accuracy and high

accuracy typing capture oligos (7), alleles whose serological

antigen type is DR6 and whose subtype is DR13

Corresponding capture oligos

Type
low accuracy
high accuracy

DRB1*1301
146
179, 184, 194, 211, 215, 234, 248, 250

DRB1*1302

179, 184, 194 211, 215, 246, 248, 250

DRB1*13021
146

DRB1*13022
146

DRB1*12031
146
199, 211 218, 239, 246, 249

DRB1*13032

199, 211 218, 239, 246, 249

DRB1*13032
146

DRB1*1304
146
194, 199, 211, 215, 234, 249

DRB1*1305
146
179, 184, 194, 210, 246, 248, 250

DRB1*1306
146
179, 184, 194, 211, 234, 248, 250

DRB1*13071
146
210, 246, 249, 250

DRB1*13072
146
201, 210, 246, 249

DRB1*1308
146
179, 188, 211, 215, 234, 248, 250

DRB1*1309
146
179, 184, 194, 211, 212, 234, 248, 250

DRB1*1310
146
179, 184, 194, 211, 218, 234, 248, 250

DRB1*1311
146
194, 210, 249, 250

DRB1*1312
146
199, 211, 246, 249

DRB1*1313
146
199, 211, 222, 246, 249

DRB1*1314

194, 210, 246, 249, 250

DRB1*13142
146

DRB1*1315
146
174, 184, 194, 211, 215, 234, 248, 250

DRB1*1316
146
179, 184, 194, 211, 215, 235, 248, 250

DRB1*1317
146
158, 194, 211, 215, 234, 249, 250

DRB1*1318
146
179, 184, 194, 210, 222, 234, 248, 250

DRB1*1319
146
174, 188, 211, 215, 222, 234, 248, 250

DRB1*1320
146
179, 184, 194, 215, 234, 248, 250

DRB1*1321
146
194, 199, 210, 246, 249

DRB1*1322
146
194, 211, 215, 234, 249, 250

DRB1*1323
146
194, 211, 215, 239, 246, 249, 250

DRB1*1324
146
194, 210, 215, 234, 249, 250

DRB1*1325
146
194, 249, 250

DRB1*1326
146
174, 184, 201, 210, 220, 248

DRB1*1327
146
171, 179, 184, 194, 211, 215, 220, 234, 248, 250

DRB1*1328
146
179, 184, 194, 211 215, 237, 248, 250

DRB1*1329
146
179, 184, 194, 215, 246, 248, 250

DRB1*1330
146
194, 199 211, 246, 249

DRB1*1331
146
179, 184 194 211 215, 246, 248, 250

DRB1*1332
146
179, 184, 199, 211, 215, 234, 248

DRB1*1333
146
199, 211, 218, 225, 229, 249

DRB1*1334
146
179, 189, 194, 211, 215, 240, 246, 248, 250

DRB1*1335
146

DRB1*1336
146

DRB1*1337
146

DRB1*1338
146

DRB1*1339
146

DRB1*1340
146

DRB1*1341
146

[0121]

12

TABLE 12

Correspondence of DRB1 types and low accuracy and high

accuracy typing capture oligos (8), alleles whose serological

antigen type is DR6 and whose subtype is DR14

Corresponding capture oligos

Type
low accuracy
high accuracy

DRB1*1401
146
179, 188, 200, 214, 223, 232, 234, 244, 248

DRB1*1402
146
174, 184, 213, 246, 248, 250

DRB1*1403
146
174, 184, 222, 246, 248, 250

DRB1*1404
146
158, 179, 188, 200, 214, 223, 232, 234, 244, 248

DRB1*1405
146
159, 179, 188, 205, 214, 223, 232, 234, 248

DRB1*1406
146
174, 184, 213, 234, 248, 250

DRB1*1407
146
179, 188, 200, 214, 223, 232, 244, 248

DRB1*1408
146
179, 188, 203, 214, 223, 232, 234, 244, 248

DRB1*1409
146
179, 184, 213, 246, 248, 250

DRB1*1410
147
160, 179, 188, 200, 214, 223, 232, 234, 244, 248

DRB1*1411
146
158, 179, 188, 206, 214, 223, 232, 248

DRB1*1412

174, 184, 222, 248, 250

DRB1*1413
146
174, 184, 199, 213, 248

DRB1*1414
146
179, 188, 214, 223, 232, 246, 248, 250

DRB1*1415

158, 179, 188, 210, 222, 234, 248, 250

DRB1*1416
146
179, 188, 200, 211, 215, 234, 244, 248

DRB1*1417
146
179, 184, 194, 213, 234, 248, 250

DRB1*1418
146
174, 184, 205, 214, 223, 232, 234, 248

DRB1*1419
146
174, 184, 216, 246, 248, 250

DRB1*1420
146
174, 188, 213, 248, 250

DRB1*1421
146
179, 184, 194, 216, 248, 250

DRB1*1422
146
179, 188 200, 210, 244, 246, 248

DRB1*1423
146
179, 188, 214, 223, 232, 234, 248, 250

DRB1*1424
146
174, 184, 211 212, 246, 248, 250

DRB1*1425
146
200, 210, 244, 249

DRB1*1426
146
170, 179, 188, 200, 214, 223, 232, 234, 244, 248

DRB1*1427
146
174, 184 210, 222, 246, 248, 250

DRB1*1428
146
158, 179, 188, 200, 214, 223, 232, 244, 248

DRB1*1429
146
174, 184, 213, 236, 248, 250

DRB1*1430
146
179, 184 194, 213, 246, 248, 250

DRB1*1431
146
158, 179, 188, 200, 214, 232, 234, 244, 2480

DRB1*1432
146

DRB1*1433
146
179, 184, 194, 213, 223, 234, 248, 250

DRB1*1434
146

DRB1*1435
146

DRB1*1436
146

[0122]

13

TABLE 13

Correspondence of DRB1 types and low accuracy and high accuracy typing capture

oligos (9), alleles whose serological antigen type is DR7, DR8, DR9 or DR10

Corresponding capture oligos

Type
low accuracy
high accuracy

DRB1*0701

164, 169, 170, 176, 188, 198, 202, 211, 217, 227, 231, 246, 247

DRB1*07011
148

DRB1*07012
148

DRB1*0703
148
164, 169, 170, 177, 188, 198, 202, 211, 217, 227, 231, 247

DRB1*0704
148
164, 169, 170, 176, 188, 198, 202, 211, 217, 227, 230, 247

DRB1*0801
146
158, 199, 210, 222, 239, 246, 249

DRB1*08021
146
158, 210, 222, 246, 249, 250

DRB1*08022
146
158, 210, 222, 246, 249, 250

DRB1*08032
146
158, 199, 211, 222, 246, 249

DRB1*08041
146
158, 210, 222, 234, 249, 250

DRB1*08042

158, 210, 222, 238, 239, 249, 250

DRB1*08043
146
158, 210, 222, 238, 239, 249, 250

DRB1*0805
146
158, 199, 210, 249

DRB1*0806
146
158, 199, 210, 222, 234, 249

DRB1*0807
146
158, 210, 222, 239, 246, 249, 250

DRB1*0808
146
158, 200, 210, 222, 244, 249

DRB1*0809

168, 179, 188, 210, 222, 239, 246, 248, 250

DRB1*0810
146
158, 199, 211, 222, 234, 249

DRB1*0811
146
158, 210, 222, 239, 246, 249, 250

DRB1*0812
146
158, 199, 211, 222, 249

DRB1*0813
146
158, 222, 249, 250

DRB1*0814
146
167, 199, 211 222, 2467, 249

DRB1*0815
146
158203211222, 244, 246, 249

DRB1*0816
146
158, 185, 199, 210, 222

DRB1*0817
146
158, 194, 199, 210, 222, 249

DRB1*0818
146
158, 199, 211, 246, 249

DRB1*0819
146
58, 211 222, 246, 249, 250

DRB1*0820
146

DRB1*0821
146
168, 179, 188, 210, 222, 239, 246, 248, 250

DRB1*09012
150
163, 169, 175, 184, 202, 210, 214, 223, 231, 243

DRB1*10011
151

DRB1*10012
151

[0123]

14

TABLE 14

Correspondence of DRB3 types and low accuracy

typing and high accuracy typing capture oligos

Corresponding capture oligos

low

Type
accuracy
High accuracy

DRB3*01011
152
252, 255, 258, 260, 265, 267, 271, 273, 275, 277, 279

DRB3*01012
152
252, 255, 258, 260, 265, 267, 271, 273, 275, 277, 279

DRB3*01013
152
252, 255, 258, 260, 265, 268, 271, 273, 275, 277, 279

DRB3*01014
152
252, 255, 258, 260, 265, 267, 271, 273, 275, 278, 279

DRB3*0102
153
253, 255, 258, 260, 265, 267, 271, 273, 275, 277, 279

DRB3*0103
152
252, 255, 258, 260, 265, 267, 271, 273, 275, 277, 279

DRB3*0104
152
252, 255, 258, 260, 265, 267, 271, 273, 275, 277, 279

DRB3*0105
152
252, 256, 258, 260, 265, 267, 271, 273, 275, 277, 279

DRB3*0106
152
252, 255, 258, 261, 265, 267, 271, 273, 275, 277, 279

DRB3*0107
152
252, 255, 258, 262, 266, 269, 272, 273, 275, 277, 279

DRB3*0201
154
254, 257, 259, 262, 266, 269, 272, 273, 275, 277, 280

DRB3*02021
154
254, 257, 259, 262, 266, 269, 272, 273, 275, 277, 279

DRB3*02022
154
254, 257, 259, 262, 266, 269, 272, 274, 275, 277, 279

DRB3*02023
154
254, 257, 259, 262, 266, 269, 272, 273, 276, 277, 279

DRB3*0203
154
254, 257, 259, 263, 266, 269, 272, 273, 275, 277, 279

DRB3*0204
154
254, 257, 259, 262, 266, 269, 271, 274, 275, 277, 280

DRB3*0205
154
254, 257, 258, 262, 266, 269, 272, 273, 275, 277, 279

DRB3*0206
154
254, 257, 259, 264, 266, 269, 272, 273, 275, 277, 279

DRB3*0207
154
254, 257, 259, 262, 266, 267, 272, 273, 275, 277, 279

DRB3*0208
154
254, 257, 259, 262, 266, 270, 272, 273, 275, 277, 279

DRB3*0210
154
254, 257, 259, 262, 265, 269, 272, 273, 275, 277, 279

DRB3*0211
154
254, 257, 259, 262, 266, 269, 272, 273, 275, 277, 279

DRB3*0212
154
254, 257, 259, 262, 266, 269, 272, 273, 275, 277, 279

DRB3*0301
154
254, 257, 258, 261, 265, 267, 272, 273, 275, 277, 280

DRB3*0302
154
254, 257, 259, 261, 265, 267, 272, 273, 275, 277, 280

DRB3*0303
154
254, 257, 258, 261, 265, 267, 271, 273, 275, 277, 279

[0124]

15

TABLE 15

Correspondence of DRB4 types and low accuracy

typing and high accuracy typing capture oligos

Corresponding capture oligos

Type
low accuracy
high accuracy

DRB4*01011
155
281, 284, 286, 288

DRB4*0102

282, 284, 287

DRB4*0103101
155
281, 284, 287, 288

DRB4*0103102N

287

DRB4*01032
155
281, 284, 287, 289

DRB4*0104
155
283, 284

DRB4*0105
155
281, 285

DRB4*0201N
155
281, 284, 286

DRB4*0301N

286

[0125]

16

TABLE 16

Correspondence of DRB5 types and low accuracy

typing and high accuracy typing capture oligos

Corresponding capture oligos

Type
low accuracy
high accuracy

DRB5*01011
156
290, 292, 295, 297, 302, 304, 306

DRB5*01012
156
290, 292, 295, 297, 300, 305, 306

DRB5*0102
156
291, 293, 295, 297, 302, 304, 306

DRB5*0103
156
291, 293, 295, 298, 304, 306

DRB5*0104
156
290, 292, 295, 297, 303, 306

DRB5*0105
156
290, 294, 295, 297, 302, 304, 306

DRB5*0106
156
290, 292, 296, 299, 301, 305, 307

DRB5*0107
156
290, 292, 296, 297, 302, 305, 307

DRB5*0108N
156
291, 293, 295, 297, 302, 304, 306

DRB5*0109
156
290, 292, 295, 297, 302, 304, 306

DRB5*0110N
156
291, 293, 295, 297, 302, 304, 306

DRB5*0202
156
291, 293, 296, 299, 301, 305, 306

DRB5*0203
156
291, 293, 296, 299, 301, 305, 306

DRB5*0204
156
291, 293, 295, 299, 301, 305, 307

[0126]

17

TABLE 17

Correspondence of DRB2, DRB6 and DRB7 types and low accuracy

typing and high accuracy typing capture oligos

Corresponding capture oligos

Type
low accuracy
high accuracy

DRB2*0101

251

DRB6*0101
155
308, 310, 312, 314, 316, 318

DRB6*0201
155
309, 311, 313, 315, 317, 319

DRB6*0202

309, 311, 313, 315, 317, 320

DRB7*01011

321

DRB7*01012

322

DRB7*01011
155
323

[0127]

18

TABLE 18

Correspondence of DPA types and high

accuracy typing capture oligos

Type
Corresponding capture oligos

DPA1*0103
324, 326, 330, 331, 333, 336, 338, 341, 343, 345, 347

DPA1*0104
324, 326, 330, 331, 334, 336, 338, 341, 343, 345, 347

DPA1*0105
324, 326, 330, 331, 333, 336, 338, 341, 343, 345, 348

DPA1*0106
324, 326, 330, 331, 333, 337, 339, 341, 343, 345, 347

DPA1*02011
324, 327, 330, 331, 333, 337, 339, 342, 343, 345, 348

DPA1*02012
324, 326, 330, 331, 333, 337, 339, 342, 343, 345, 348

DPA1*02013
324, 326, 330, 331, 333, 337, 338, 342, 343, 345

DPA1*02014
324, 330, 331, 333, 337, 339, 342, 343, 345, 348

DPA1*02021
325, 327, 329, 331, 333, 337, 340, 342, 343, 345, 348

DPA1*02022
325, 327, 329, 331, 333, 337, 338, 342, 343, 345, 348

DPA1*0203
324, 327, 330, 331, 333, 336, 338, 342, 343, 345, 347

DPA1*0301
325, 327, 330, 331, 333, 336, 338, 341, 344, 345, 347

DPA1*0302
325, 327, 330, 331, 333, 336, 338, 341, 343, 345, 347

DPA1*0401
324, 326, 328, 332, 335, 336, 338, 342, 343, 346, 348

[0128]

19

TABLE 19

Correspondence of DPB high accuracy typing capture (1)

Type
Corresponding capture oligos

DPB1*01011
349, 254, 358, 361, 366, 367, 376

DPB1*01012
350, 355, 358, 364, 365, 368, 373, 376

DPB1*02011
350, 354, 358, 364, 365, 368, 373, 376

DPB1*02012
350, 354, 358, 364, 365, 369, 376

DPB1*02013
350, 354, 358, 362, 365, 371, 376

DPB1*0202
349, 356, 358, 364, 365, 370, 374, 377

DPB1*0301
350, 354, 358, 363, 365, 367, 376

DPB1*0401
350, 354, 358, 364, 365, 368, 373, 376

DPB1*0402
350, 354, 358, 362, 365, 371, 376

DPB1*0501
349, 356, 358, 364, 365, 370, 374, 377

DPB1*0601
350, 354, 358, 364, 365, 368, 373, 376

DPB1*0801
351, 356, 358, 364, 365, 370, 374, 376

DPB1*0901
351, 356, 358, 364, 365, 368, 373, 376, 386, 388, 390, 393, 396

DPB1*1001
349, 356, 360, 361, 366, 367, 377, 384, 385, 388, 391, 393, 396

DPB1*11011
349, 356, 359, 361, 366, 367, 377, 384, 386, 388, 391, 393, 396

DPB1*11012
349, 356, 358, 361, 365, 367, 376, 386, 388, 392, 393, 396

DPB1*1301
351, 356, 358, 364, 365, 370, 374, 377, 382, 386, 388, 390, 393, 396

DPB1*1401
349, 354, 360, 361, 366, 367, 377, 384, 386, 388, 391, 395, 396

DPB1*1501
350, 354, 358, 364, 365, 368, 373, 376, 386, 388, 391, 393, 396

DPB1*1601
351, 356, 358, 364, 365, 370, 374, 376, 386, 388, 391, 393, 396

DPB1*1701
349, 354, 358, 364, 365, 368, 373, 376, 382, 386, 388, 391, 395, 396

DPB1*1801
350, 354, 358, 364, 365, 371, 376, 386, 388, 392, 393, 396

DPB1*1901
349, 356, 358, 364, 365, 370, 374, 377, 382, 386, 388, 391, 393, 396

DPB1*20011
349, 356, 358, 364, 365, 370, 374, 377, 382, 386, 388, 391, 393, 396

DPB1*20012
349, 356, 358, 362, 365, 371, 376, 386, 388, 391, 393, 396

DPB1*2101
350, 354, 358, 362, 365, 371, 376, 386, 388, 391, 393, 396

DPB1*2201
350, 354, 358, 364, 365, 367, 376, 382, 386, 388, 391, 394, 396

DPB1*2301
350, 354, 358, 363, 365, 371, 376, 382, 386, 388, 391, 394, 396

DPB1*2401
349, 356, 358, 364, 365, 368, 373, 377, 382, 386, 388, 390, 393, 396

DPB1*2501
349, 356, 358, 361, 366, 367, 376, 382, 386, 388, 393, 396

DPB1*26011
349, 356, 358, 361, 365, 367, 376, 382, 386, 388, 390, 393, 396

DPB1*26012
349, 356, 358, 361, 365, 367, 376, 382, 386, 388, 391, 393, 396

DPB1*2701
350, 354, 368, 363, 365, 368, 373, 377, 382, 386, 388, 391, 395, 396

DPB1*2801
349, 356, 358, 364, 365, 370, 374, 377, 386, 388, 390, 393, 396

DPB1*2901
351, 356, 358, 364, 365, 371, 376, 386, 388, 391, 393, 396

DPB1*3001
350, 354, 358, 363, 365, 367, 377, 382, 387, 391, 393, 396

DPB1*3101
350, 354, 358, 364, 365, 372, 375, 376, 386, 388, 391, 394, 396

DPB1*3201
350, 354, 358, 363, 365, 367, 376, 386, 388, 391, 394, 396

DPB1*3301
350, 354, 358, 362, 365, 367, 377, 382, 387, 391, 395, 396

DPB1*3401
351, 356, 358, 364, 365, 370, 374, 376, 382, 386, 388, 390, 393, 396

DPB1*3501
349, 356, 358, 362, 365, 371, 376, 382, 386, 388, 391, 393, 396

DPB1*3601
349, 356, 358, 364, 365, 368, 373, 376, 386, 388, 390, 393, 396

DPB1*3701
350, 354, 358, 362, 365, 371, 376, 382, 386, 388, 391, 393, 397

DPB1*3801
350, 354, 358, 361, 365, 367, 376, 382, 386, 388, 391, 394, 396

DPB1*3901
350, 354, 358, 361, 365, 367, 376, 382, 386, 388, 391, 395, 396

DPB1*4001
350, 354, 358, 364, 365, 368, 373, 378, 386, 388, 391, 394, 396

[0129]

20

TABLE 20

Correspondence of DPB types and high accuracy typing capture oligos (2)

Type
Corresponding capture oligos

DPB1*4101
349, 356, 358, 362, 365, 370, 374, 377, 386, 388, 390, 393, 396

DPB1*4401
351, 356, 358, 364, 365, 368, 373, 377, 382, 386, 388, 390, 393, 396

DPB1*4501
350, 354, 358, 364, 365, 370, 374, 376, 386, 388, 391, 394, 396

DPB1*4601
350, 354, 358, 364, 365, 371, 376, 386, 388, 391, 394, 396

DPB1*4701
350, 354, 358, 362, 365, 368, 373, 376, 386, 388, 391, 394, 396

DPB1*4801
350, 354, 358, 361, 365, 368, 373, 376, 382, 386, 388, 391, 394, 396

DPB1*4901
349, 354, 358, 364, 365, 370, 374, 377, 382, 386, 388, 390, 393, 396

DPB1*5001
350, 354, 358, 363, 365, 368, 373, 376, 382, 386, 388, 391, 394, 396

DPB1*5101
349, 356, 358, 364, 365, 367, 377, 382, 386, 388, 390, 393, 396

DPB1*5201
350, 354, 358, 361, 365, 368, 373, 376, 382, 386, 388, 391, 395, 396

DPB1*5301
351, 356, 358, 364, 365, 371, 376, 386, 388, 390, 393, 396

DPB1*5401
351, 356, 358, 364, 365, 367, 376, 386, 388, 391, 393, 396

DPB1*5501
349, 356, 358, 363, 365, 367, 377, 382, 386, 388, 390, 393, 396

DPB1*5601
350, 354, 358, 364, 365, 370, 374, 377, 382, 386, 388, 390, 393, 396

DPB1*5701
351, 356, 358, 362, 365, 367, 376, 386, 388, 391, 393, 396

DPB1*5801
350, 354, 358, 364, 365, 368, 373, 377, 382, 386, 388, 391, 394, 396

DPB1*5901
350, 354, 358, 364, 365, 368, 373, 379, 382, 386, 388, 391, 394, 396

DPB1*6001
349, 356, 358, 364, 365, 370, 374, 380, 381, 385, 386, 388, 390, 393

DPB1*6101N
350, 354, 358, 362, 365, 367, 376, 382, 386, 388, 391, 395, 396

DPB1*6201
350, 354, 358, 362, 365, 367, 376, 382, 386, 388, 391, 393, 396

DPB1*6301
352, 356, 358, 364, 365, 370, 374, 377, 386, 388, 391, 393, 396

DPB1*6401N
350, 354, 358, 361, 365, 367, 376, 382, 386, 388, 390, 393, 396

DPB1*6501
351, 356, 358, 363, 365, 367, 376, 382, 386, 388, 391, 394, 396

DPB1*6601
351, 356, 358, 364, 365, 367, 377, 382, 386, 388, 390, 393, 396

DPB1*6701
350, 354, 358, 364, 365, 368, 373, 376, 382, 386, 388, 390, 393, 396

DPB1*6801
349, 356, 358, 364, 365, 370, 374, 377, 384, 386, 388, 391, 393, 396

DPB1*6901
353, 356, 358, 364, 365, 370, 374, 377, 382, 386, 388, 390, 393, 396

DPB1*7001
350, 354, 358, 364, 365, 367, 376, 386, 388, 391, 394, 396

DPB1*7101
350, 354, 358, 363, 365, 367, 377, 382, 386, 388, 391, 394, 396

DPB1*7201
350, 354, 358, 364, 365, 368, 373, 377, 382, 386, 388, 390, 394, 396

DPB1*7301
349, 356, 359, 364, 366, 367, 377, 386, 388, 391, 395, 396

DPB1*7401
350, 354, 358, 364, 365, 368, 373, 376, 382, 386, 388, 390, 394, 396

DPB1*7501
351, 356, 358, 363, 365, 368, 373, 377, 382, 386, 388, 390, 393, 396

DPB1*7601
350, 357, 358, 361, 365, 368, 373, 376, 382, 386, 388, 391, 394, 396

DPB1*7701
349, 356, 358, 364, 365, 370, 374, 377, 382, 389, 390, 393, 396

DPB1*7801
349, 356, 358, 364, 365, 368, 373, 376, 382, 386, 388, 390, 393, 396

DPB1*7901
349, 356, 358, 364, 365, 368, 373, 376, 382, 386, 388, 390, 393, 396

[0130] The kit of the present invention includes a substrate on which capture oligos are immobilized. The kit of the present invention can include primers for preparing a nucleic acid target or reagents for hybridization such as a labeled nucleic acid target, buffer and enzyme conjugate recognizing a hapten.

BRIEF DESCRIPTION OF THE DRAWINGS

[0131]
FIG. 1 shows positions of capture oligos (for HLA-DQA1) immobilized on a substrate. Numbers in the figure represent sequence numbers (the same shall apply in FIGS. 2-7).

[0132]
FIG. 2 shows positions of capture oligos (for HLA-DQB1) immobilized on a substrate.

[0133]
FIG. 3 shows positions of capture oligos (for HLA-DRA) immobilized on a substrate.

[0134]
FIG. 4 shows positions of capture oligos (for HLA-DRB1) immobilized on a substrate.

[0135]
FIG. 5 shows positions of capture oligos (for HLA-DRB3, HLA-DRB4, HLA-DRB5 and HLA-DRB6,) immobilized on a substrate.

[0136]
FIG. 6 shows positions of capture oligos (for HLA-DPA1) immobilized on a substrate.

[0137]
FIG. 7 shows positions of capture oligos (for HLA-DPB1) immobilized on a substrate.

[0138]
FIG. 8 shows a schematic view of a kit of the present invention and a detection result of DRA typing using the same (detection result typed as DRA*1010).

[0139] Numbers in the figure represent sequence numbers. B indicates that an oligonucleotide in which biotin is introduced at 5′ end is immobilized. indicates that hybridization is not obtained. indicates that a hybridization signal is obtained (the same shall apply in FIGS. 9 and 10).

[0140]
FIG. 9 shows a schematic view of the kit of the present invention and a detection result of DRB low resolution typing using the same (detection result typed as DR4).

[0141]
FIG. 10 shows a schematic view of the kit of the present invention and a detection result of DRB1 high resolution typing using the same (detection result typed as DRB*04011).

[0142]
FIG. 11 shows positions of capture oligos (for HLA-DPB1) immobilized on a substrate.

[0143]
FIG. 12 shows positions of capture oligos (for HLA-DQB1) immobilized on a substrate.

[0144]
FIG. 13 shows positions of capture oligos (for HLA-DRB1) immobilized on a substrate.

[0145]
FIG. 14 shows positions of capture oligos (for HLA-DRB pseudogene) immobilized on a substrate.

[0146]
FIG. 15 shows positions of capture oligos (for HLA-DPB3, 4, 5) immobilized on a substrate.

[0147]
FIG. 16 shows positions of capture oligos (for HLA-A) immobilized on a substrate.

[0148]
FIG. 17 shows positions of capture oligos (for HLA-B) immobilized on a substrate.

[0149]
FIG. 18 shows a schematic view of the kit of the present invention (A) and a photograph showing detection result of DPB1 typing using the same (detection result typed as DPB1*01011) (B).

[0150]
FIG. 19 shows a schematic view of the kit of the present invention (A) and a photograph showing detection result of DQB1 typing using the same (detection result typed as DQB1*05031) (B).

[0151]
FIG. 20 shows a schematic view of the kit of the present invention (A) and a photograph showing detection result of DRB1 typing using the same (detection result typed as DRB1*0101) (B).

[0152]
FIG. 21 shows a schematic view of the kit of the present invention (A) and a photograph showing detection result of DRB9 typing using the same (detection result typed as DRB9 0101) (B).

[0153]
FIG. 22 shows a schematic view of the kit of the present invention (A) and a photograph showing detection result of DRB3 typing using the same (detection result typed as DRB3 0301) (B).

[0154]
FIG. 23 shows a schematic view of the kit of the present invention (A) and a photograph showing detection result of A typing using the same (detection result typed as A 01011) (B).

[0155]
FIG. 24 shows a schematic view of. the kit of the present invention (A) and a photograph showing detection result of B typing using the same (detection result typed as B 0724) (B).

BEST MODE FOR CARRYING OUT THE INVENTION

[0156] Hereafter, the present invention will be explained more specifically with reference to the following examples.

EXAMPLE 1

Synthesis of Oligonucleotides

[0157] According to a usual method, oligonucleotides having an amino group or hydroxyl group at 5′ end were synthesized by using an oligonucleotide synthesizer (Perkin-Elmer Applied Biosystems), deprotected and dried. These dried oligonucleotides were dissolved in a buffer of 10 mM Tris-HCl (pH 7.5) and 1 mM EDTA to prepare 100 pmol/μL solutions of oligonucleotides. This synthesis method can be employed both for oligonucleotides used as capture oligos and those used as primers. The nucleotide sequences of the synthesized oligonucleotides are listed in Sequence Listing as SEQ ID NOS: 1-447. Among these, SEQ ID NOS: 1-397 are capture oligos and SEQ ID NOS: 398-447 are primers.

EXAMPLE 2

Spotting of Capture Oligos on Substrate (Utilizing Oligonucleotide Having Amino Group at 5′ End)

[0158] In an amount of 10 μL of a microspotting solution (TeleChem International Inc.) was mixed with 10 μL of a solution of oligonucleotide having an amino group at 5′ end and added onto a microtiter plate (Greiner Laboratory Inc.). Silanized slide glass (Matsunami Glass Ind. Ltd.) was placed at a predetermined position in a. spotting machine and then the spotting machine was operated. After the spotting was completed, the slide glass was exposed to vapor from hot water for a few seconds and then irradiated with ultraviolet ray of 30 mJ. After exposed to vapor again for a few seconds, the slide glass was placed on a hot plate to remove moisture. The slide glass was rinsed with 0.1% sodium dodecyl sulfate aqueous solution and then with distilled water. The slide glass was blocked by immersing it in 100 mM Tris-HCl (pH 7.5), 100 mM NaCl and 0.1% Triton X-100 containing 3% bovine serum albumin (BSA) at room temperature for 30 minutes. Then, after dried at room temperature, the slide glass was washed with a buffer of 10 mM Tris-HCl (pH 7.5) and 1 mM EDTA. The slide glass was dried at room temperature again and maintained in a dry state in a dark cold place until use.

EXAMPLE 3

Spotting of Capture Oligos on Substrate (Utilizing Oligonucleotide Having Hydroxyl Group at 5′ End)

[0159] In an amount of 10 μL of a microspotting solution (2 M sodium chloride aqueous solution) was mixed with 10 μL of a solution of oligonucleotide having a hydroxyl group at 5′ at end and added onto a microtiter plate (Greiner Laboratory Inc.). Silanized slide glass (Matsunami Glass Ind. Ltd.) was placed at a predetermined position in a spotting machine and then the spotting machine was operated. After the spotting was completed, the slide glass was placed in a drier at 37° C. for 30 minutes. The slide glass was blocked by immersing it in 100 mM Tris-HCl (pH 7.5), 100 mM NaCl and 0.1% Triton X-100 containing 3% bovine serum albumin (BSA) at room temperature for 30 minutes. Then, after dried at room temperature, the slide glass was washed with a buffer of 10 mM Tris-HCl (pH 7.5) and 1 mM EDTA. The slide glass was dried at room temperature again and maintained in a dry state in a dark cold place until use.

EXAMPLE 4

Preparation of Nucleic Acid Target

[0160] Nucleated cells were collected from peripheral blood, cultured cells or the like, placed in a microtube and washed 3 times with physiological saline. The cells were added and mixed with 800 μl of 0.1 M Tris-HCl (pH 8.0), 0.2 M NaCl, 0.04 M EDTA and 2% SDS, then added with 120 μg of proteinase K and incubated overnight at 50° C. The mixture was added with 800 μl of 1 M Tris-HCl saturated phenol was added and rotated on a rotator for 1 hour or longer, and extracted 3 times with phenol to remove proteins. The aqueous layer was added with 2 ml of 2-propanol and 60 μl of 5 M NaCl and gently mixed, and then the precipitated DNA was quickly sucked up with a micropipette. The DNA was washed 3 times by centrifugation with addition of 70% cold ethanol. The DNA was dried under reduced pressure and dissolved in 70 μl of sterilized water to prepare a PCR template solution.

[0161] The composition for PCR amplification consisted of 2 units of Taq polymerase, 25 pmol each of primers , 5 μl of reaction buffer, 10 nmol each of dNTP, 0.5 μl of template DNA solution and sterilized water giving a total volume of 50 μl. The solution placed in a tube was set on a thermal cycler. A program was operated such that, out of a cycle of (1) 95° C., 3 minutes, (2) 95° C., 30 seconds, (3) 71° C., 30 seconds and (4) 72° C., 3 minutes, (2) and (3) should be repeated 30 times.

[0162] In this example, agarose gel electrophoresis described below was performed as a confirmation test, but is not required in identification in an actual clinical case. In an amount of 1 μl of the PCR reaction mixture was taken and mixed with 1 μl of 6× migration pigment (30% glycerol, 0.25% Bromophenol Blue, 0.25% xylene cyanol) and 4 μl of distilled water. After electrophoresis was performed on 2% agarose gel for 90 minutes at 100 V, the gel was immersed in distilled water containing 0.5 μg/ml of ethidium bromide for 30 minutes and photographed under ultraviolet ray irradiation by using a CCD camera.

EXAMPLE 5

Hybridization

[0163] In an amount of 2 μl of the nucleic acid target prepared in Example 4 was taken and mixed with 8 μl of ArrayIt Unihyb Hybridization Solution (TeleChem International Inc.), subjected to a heat treatment at 100° C. for 10 minutes, and then immersed in ice for 5 minutes. In an amount of 5 μl of this nucleic acid target solution was taken and placed on a substrate on which the capture oligos prepared in Example 2 or 3 were immobilized and then cover glass was placed thereon. This substrate was placed in a moisture box, further placed in an incubator set at 42° C. and left for 60 minutes. The substrate was taken out from the incubator and quickly immersed in 5× SSC (0.083 M NaCl and 0.083 M sodium citrate) at 4° C. to remove the cover glass. Immersion of the substrate in 5× SSC at 4° C. for 10 minutes was repeated twice and then the substrate was rinsed twice with 3 M tetramethylammonium chloride aqueous solution at room temperature. Immersion of the substrate in 3 M tetramethylammonium chloride aqueous solution at 45° C. for 20 minutes was repeated twice. Finally, the substrate was immersed in 2× SSC (0.033 M NaCl and 0.033 M sodium citrate).

EXAMPLE 6

Detection of Chemical Color Development

[0164] After hybridization was completed in Example 5, the substrate was taken out from 2× SSC. Block Ace (Dainippon Pharmaceutical Co., Ltd.) stock solution (4% aqueous solution) was placed on the substrate in an amount of 70 μl per cm2 and left at room temperature for 20 minutes, and then the solution was removed. Subsequently, a mixed solution obtained by adding 2 drops each of avidin DH (Vector Laboratories, Inc.) and biotinylated horseradish peroxidase H (Vector Laboratories, Inc.) to 5 ml of TBST (0.05 M Tris-HCl (pH 7.6), 0.15 M NaCl, 0.05% Tween 20) and mixing them was placed on the substrate in an amount of 70 μl per cm2 and left at room temperature for 30 minutes, and then the solution was removed. After immersion of the substrate in TBST at room temperature for 5 minutes was repeated twice, the substrate was taken out from the buffer and the moisture was sufficiently removed with paper towel. A TMB (3,3′,5,5′-tetramethylbenzidine) color development substrate kit (Vector Laboratories, Inc.) was placed on the substrate in amount of 70 μl per cm2 and left at room temperature for 10 minutes, and then the solution was removed. The substrate was immersed in deionized water to stop the enzymatic reaction.

[0165] The results of the above examples are shown in FIGS. 8-10. It is evident that HLA typing can be carried out by the method of the present invention.

[0166] According to the present invention, there are provided a kit and method that enable multiple specimen processing and a highly precise HLA typing with one time of test as well as oligonucleotides and primers for use in the same.

EXAMPLE 7

Typing Using Patchworks

[0167] Oligonucleotides used for preparation of arrays were synthesized in a similar manner as Example 1. Arrays were prepared in a similar manner as Example 2 or 3. Correspondence of the sequences of oligonucleotides used in arrays for typing HLA and HLA types are shown in Tables 21-32. For amplifying targets, combinations of primers shown in Table 33 were used. Typing was performed in a similar manner as Examples 4-6.

[0168] The results are shown in FIGS. 18-24. Thus, HLA typing of the test specimen can be performed with the arrays which were prepared using oligonucleotides designed according to patchworks and satellites.

21TABLE 21Correspondence of the patchwork regions and satellite regions for types of DPB1patchwork regionsatellite regionDPB1*01011DPB1DPB4DPB7DPB12DPB15DPB18DPB21DPB1*6501DPB1DPB4DPB7DPB12DPB15DPB18DPB21DPB1*01012DPB1DPB4DPB7DPB12DPB15DPB18DPB21473DPB1*8901DPB1DPB4DPB7DPB12DPB15DPB19DPB21DPB1*1301DPB2DPB4DPB7DPB12DPB16DPB20DPB21DPB1*26011DPB2DPB4DPB7DPB12DPB15DPB18DPB21473495DPB1*26012DPB2DPB4DPB7DPB12DPB15DPB18DPB21DPB1*2701DPB2DPB4DPB7DPB12DPB15DPB19DPB21DPB1*8501DPB2DPB4DPB7DPB12DPB15DPB19DPB21456DPB1*3901DPB1DPB4DPB7DPB12DPB15DPB19DPB22DPB1*4001DPB1DPB4DPB7DPB12DPB15DPB19DPB23DPB1*0401DPB1DPB3DPB7DPB12DPB15DPB19DPB22DPB1*3301DPB1DPB3DPB7DPB12DPB16DPB19DPB22DPB1*6601DPB2DPB3DPB7DPB12DPB15DPB19DPB22456DPB1*2301DPB1DPB5DPB7DPB12DPB15DPB19DPB22DPB1*7101DPB1DPB5DPB7DPB12DPB16DPB19DPB22DPB1*5501DPB2DPB5DPB7DPB12DPB16DPB19DPB21456DPB1*5801DPB2DPB6DPB7DPB12DPB16DPB19DPB21456DPB1*6301DPB1DPB6DPB7DPB12DPB15DPB19DPB21DPB1*6201DPB1DPB6DPB7DPB12DPB15DPB19DPB23DPB1*1601DPB1DPB4DPB8DPB12DPB16DPB19DPB21DPB1*4901DPB1DPB4DPB8DPB12DPB15DPB19DPB22DPB1*5301DPB1DPB4DPB8DPB12DPB15DPB19DPB23DPB1*0801DPB1DPB5DPB8DPB12DPB16DPB18DPB21DPB1*6801DPB1DPB5DPB8DPB12DPB15DPB18DPB21DPB1*7501DPB1DPB5DPB8DPB12DPB15DPB18DPB22DPB1*02012DPB1DPB5DPB8DPB12DPB16DPB19DPB22DPB1*3201DPB1DPB5DPB8DPB12DPB16DPB19DPB22481DPB1*4601DPB1DPB5DPB8DPB12DPB16DPB19DPB22482DPB1*6001DPB1DPB5DPB8DPB12DPB15DPB19DPB22487DPB1*7701DPB1DPB5DPB8DPB12DPB15DPB19DPB22464DPB1*8001DPB1DPB5DPB8DPB12DPB15DPB19DPB22DPB1*8201DPB1DPB5DPB8DPB12DPB15DPB19DPB22DPB1*0901DPB2DPB5DPB8DPB12DPB16DPB18DPB21482456DPB1*1001DPB2DPB5DPB8DPB12DPB16DPB18DPB21456DPB1*3701DPB2DPB5DPB8DPB12DPB16DPB18DPB21DPB1*3501DPB2DPB5DPB8DPB12DPB15DPB18DPB21482456DPB1*7901DPB2DPB5DPB8DPB12DPB15DPB18DPB21DPB1*8801DPB2DPB5DPB8DPB12DPB16DPB18DPB21482DPB1*1701DPB2DPB5DPB8DPB12DPB16DPB19DPB21482456DPB1*0402DPB2DPB5DPB8DPB12DPB15DPB19DPB22DPB1*1801DPB1DPB5DPB8DPB12DPB15DPB19DPB23DPB1*4801DPB1DPB6DPB8DPB12DPB16DPB19DPB22DPB1*5101DPB1DPB3DPB8DPB12DPB15DPB19DPB22DPB1*8101DPB1DPB3DPB8DPB12DPB16DPB19DPB22DPB1*02013DPB1DPB5DPB9DPB12DPB16DPB19DPB22DPB1*4701DPB1DPB5DPB10DPB12DPB16DPB19DPB22DPB1*1901DPB1DPB5DPB10DPB12DPB16DPB20DPB21DPB1*3001DPB2DPB5DPB10DPB12DPB16DPB19DPB21456DPB1*5401DPB2DPB5DPB10DPB12DPB16DPB18DPB21456DPB1*0202DPB1DPB6DPB10DPB12DPB16DPB19DPB22DPB1*2201DPB1DPB6DPB10DPB12DPB16DPB19DPB21DPB1*0501DPB1DPB6DPB10DPB12DPB15DPB19DPB21DPB1*3801DPB1DPB6DPB10DPB12DPB15DPB19DPB21465DPB1*2101DPB2DPB6DPB10DPB12DPB16DPB19DPB21DPB1*3601DPB2DPB6DPB10DPB12DPB15DPB19DPB21DPB1*2401DPB1DPB3DPB10DPB12DPB15DPB19DPB22DPB1*8401DPB1DPB5DPB11DPB12DPB15DPB18DPB22DPB1*11011DPB2DPB4DPB7DPB13DPB17DPB19DPB21467473DPB1*11012DPB2DPB4DPB7DPB13DPB17DPB19DPB21466467473DPB1*1501DPB1DPB4DPB7DPB13DPB17DPB19DPB23467473DPB1*7401DPB2DPB4DPB7DPB13DPB17DPB19DPB23467473DPB1*3101DPB1DPB3DPB7DPB13DPB15DPB19DPB21DPB1*5601DPB2DPB3DPB7DPB13DPB15DPB18DPB21DPB1*7201DPB1DPB3DPB7DPB13DPB15DPB19DPB22DPB1*3401DPB1DPB6DPB7DPB13DPB15DPB19DPB23493DPB1*5201DPB2DPB5DPB7DPB13DPB15DPB18DPB21DPB1*03012DPB2DPB5DPB8DPB13DPB15DPB18DPB21482503DPB1*1401DPB2DPB5DPB8DPB13DPB15DPB18DPB21482456DPB1*6101NDPB2DPB5DPB8DPB13DPB15DPB18DPB21482DPB1*7001DPB2DPB5DPB8DPB13DPB15DPB18DPB21482457DPB1*2501DPB2DPB5DPB8DPB13DPB15DPB18DPB21DPB1*4501DPB2DPB5DPB8DPB13DPB15DPB18DPB21456DPB1*6701DPB2DPB5DPB7DPB13DPB15DPB18DPB21456DPB1*7801DPB2DPB5DPB8DPB13DPB15DPB18DPB21482DPB1*2901DPB2DPB5DPB8DPB13DPB16DPB18DPB21482DPB1*0601DPB2DPB5DPB8DPB13DPB16DPB19DPB21482DPB1*20011DPB2DPB5DPB8DPB13DPB15DPB19DPB21482DPB1*20012DPB2DPB5DPB8DPB13DPB15DPB19DPB21482DPB1*6401NDPB2DPB5DPB8DPB13DPB16DPB19DPB21DPB1*6901DPB2DPB5DPB8DPB13DPB17DPB19DPB21482DPB1*5001DPB1DPB5DPB8DPB13DPB15DPB18DPB21482DPB1*5701DPB1DPB5DPB8DPB13DPB15DPB18DPB21482DPB1*5901DPB1DPB5DPB8DPB13DPB15DPB19DPB22DPB1*7301DPB1DPB5DPB8DPB13DPB15DPB18DPB22DPB1*8701DPB2DPB5DPB7DPB13DPB15DPB19DPB22DPB1*2801DPB1DPB3DPB8DPB13DPB15DPB19DPB23DPB1*7601DPB2DPB3DPB8DPB13DPB15DPB18DPB21482456DPB1*4401DPB2DPB6DPB8DPB13DPB16DPB18DPB21482DPB1*03011DPB2DPB5DPB10DPB13DPB15DPB18DPB21482DPB1*4101DPB1DPB5DPB8DPB14DPB16DPB19DPB22DPB1*8301DPB1DPB5DPB8DPB14DPB15DPB19DPB22DPB1*8601DPB2DPB5DPB8DPB9DPB16DPB19DPB22482

[0169]

22

TABLE 22

Correspondence of Patchwork

DPB1 and SEQ ID NOS. for DPB1

Patchwork
SEQ ID NOS.

F
458
460
462

DPB2
459
461
463

DPB3
468

DPB4
469
472

DPB5
470

DPB6
471

DPB7
474

DPB8
475
479
480

DPB9
476

DPB10
477

DPB11
478

DPB12
483

DPB13
484
486

DPB14
485

DPB15
489
92

DPB16
490

DPB17
491

DPB18
496
498

DPB19
497

DPB20
499

DPB21
500

DPB22
501

DPB23
502

[0170]

23

TABLE 23

Correspondence of the patchwork regions and satellite regions for types of DQB1

patchwork region

DQB1*0201
DQB1
DQB5
DQB8
DQB10
DQB15
DQB19
DQB23
DQB26
DQB30
DQB34

DQB1*0202
DQB1
DQB5
DQB8
DQB10
DQB15
DQB19
DQB23
DQB26
DQB30
DQB34

DQB1*0203
DQB1
DQB5
DQB8
DQB10
DQB15
DQB18
DQB23
DQB26
DQB30
DQB33
DQB34

DQB1*05031
DQB1
DQB4
DQB7
DQB10
DQB14
DQB18
DQB22
DQB24
DQB29

DQB1*03032
DQB1
DQB5
DQB8
DQB11
DQB14
DQB18
DQB22
DQB27
DQB30
DQB35

DQB1*0310
DQB1
DQB6
DQB9
DQB11
DQB14
DQB18
DQB22
DQB27
DQB30
DQB35

DQB1*03033
DQB1
DQB5
DQB8
DQB12
DQB14
DQB18
DQB22
DQB27
DQB30
DQB35

DQB1*06011
DQB3
DQB6
DQB9
DQB10
DQB14
DQB18
DQB23
DQB27
DQB31

DQB1*06013
DQB6
DQB9
DQB10
DQB14
DQB18
DQB23
DQB27
DQB31

DQB1*06012
DQB3
DQB6
DQB9
DQB10
DQB14
DQB18
DQB23
DQB27

DQB1*0306
DQB1
DQB5
DQB8
DQB11
DQB14
DQB18
DQB23
DQB25
DQB30
DQB35

DQB1*0401
DQB2
DQB5
DQB7
DQB12
DQB14
DQB18
DQB23
DQB25
DQB30

DQB1*0402
DQB2
DQB5
DQB7
DQB12
DQB14
DQB18
DQB23
DQB25
DQB30

DQB1*05032
DQB7
DQB10
DQB14
DQB20
DQB22

DQB1*0302
DQB1
DQB5
DQB8
DQB11
DQB14
DQB19
DQB22
DQB27
DQB30
DQB33

DQB1*0307
DQB1
DQB5
DQB8
DQB11
DQB14
DQB19
DQB22
DQB27
DQB30
DQB35

DQB1*0308
DQB1
DQB5
DQB8
DQB11
DQB14
DQB19
DQB22
DQB28
DQB30
DQB35

DQB1*0309
DQB1
DQB5
DQB7
DQB12
DQB14
DQB19
DQB22
DQB27
DQB30
DQB35

DQB1*0309
DQB1
DQB6
DQB9
DQB11
DQB13
DQB18
DQB22
DQB27
DQB30
DQB35

DQB1*03011
DQB1
DQB6
DQB9
DQB11
DQB13
DQB18
DQB22
DQB27
DQB30
DQB35

DQB1*03012
DQB1
DQB6
DQB9
DQB12
DQB13
DQB18
DQB22
DQB27
DQB30
DQB35

DQB1*05011
DQB1
DQB4
DQB7
DQB10
DQB13
DQB16
DQB22
DQB24
DQB29

DQB1*05012
DQB1
DQB4
DQB7
DQB10
DQB13
DQB16
DQB22
DQB24
DQB29

DQB1*06041
DQB1
DQB5
DQB8
DQB12
DQB13
DQB16
DQB22
DQB27
DQB32

DQB1*06042
DQB1
DQB5
DQB8
DQB12
DQB13
DQB16
DQB22
DQB27
DQB32

DQB1*0606
DQB1
DQB4
DQB8
DQB12
DQB13
DQB16
DQB22
DQB27

DQB1*0609
DQB8
DQB12
DQB13
DQB16
DQB22
DQB27
DQB32

DQB1*06051
DQB1
DQB5
DQB8
DQB12
DQB13
DQB16
DQB22
DQB27
DQB32

DQB1*0608
DQB1
DQB5
DQB8
DQB12
DQB13
DQB16
DQB22
DQB28
DQB31

DQB1*0613
DQB1
DQB5
DQB8
DQB12
DQB13
DQB16
DQB22
DQB28
DQB31

DQB1*0612
DQB2
DQB5
DQB8
DQB12
DQB13
DQB16
DQB22
DQB28
DQB32

DQB1*0617
DQB1
DQB5
DQB8
DQB12
DQB13
DQB16
DQB22
DQB24
DQB32

DQB1*0502
DQB1
DQB4
DQB7
DQB10
DQB13
DQB17
DQB22
DQB24
DQB29

DQB1*0504
DQB1
DQB4
DQB7
DQB10
DQB13
DQB17
DQB23
DQB25
DQB33

DQB1*0610
DQB2
DQB5
DQB8
DQB12
DQB13
DQB17
DQB22
DQB28
DQB31

DQB1*06111
DQB2
DQB5
DQB8
DQB12
DQB13
DQB20
DQB22
DQB28
DQB31

DQB1*06112
DQB1
DQB5
DQB8
DQB12
DQB13
DQB20
DQB22
DQB28
DQB31

DQB1*0603
DQB1
DQB5
DQB8
DQB12
DQB13
DQB20
DQB22
DQB28
DQB31

DQB1*0602
DQB1
DQB5
DQB8
DQB12
DQB13
DQB20
DQB22
DQB28
DQB31

DQB1*0616
DQB2
DQB5
DQB8
DQB12
DQB13
DQB20
DQB22
DQB28
DQB31

DQB1*0614
DQB2
DQB5
DQB8
DQB12
DQB13
DQB20
DQB22
DQB28
DQB31

DQB1*0615
DQB1
DQB5
DQB8
DQB12
DQB13
DQB20
DQB22
DQB27
DQB32

DQB1*0607
DQB2
DQB5
DQB8
DQB12
DQB13
DQB20
DQB22
DQB27
DQB32

DQB1*0304
DQB1
DQB6
DQB9
DQB11
DQB13
DQB19
DQB22
DQB27
DQB30
DQB35

DQB1*06052
DQB8
DQB12
DQB13
DQB21
DQB22
DQB27

satellite region

DQB1*0201
514
525
527
539
549
552
553
581

DQB1*0202
514
525
527
539
549
552
553
581

DQB1*0203
514
525
527
529
539
549
552
553
581

DQB1*05031
549
584

DQB1*03032
526
549
553
582
583

DQB1*0310
526
549
582
583

DQB1*03033
526
553
582
583

DQB1*06011
513
526
530
549
580
582
583

DQB1*06013
513
526
530
549
580
582
583

DQB1*06012
526
530
549
551
580
582
583

DQB1*0306
515
526
549
553
571
582
583

DQB1*0401
515
516
526
549
553
556
571
585

DQB1*0402
515
526
549
553
556
571
585

DQB1*05032
549

DQB1*0302
526
549
553
582
583

DQB1*0307
526
550
553
582
583

DQB1*0308
526
549
553
582
583

DQB1*0309
515
526
549
553
582
583

DQB1*0309
526
538
549
553
582
583

DQB1*03011
526
538
549
553
582
583

DQB1*03012
526
538
549
553
582
583

DQB1*05011

DQB1*05012
549
584

DQB1*06041
524
549
582
583

DQB1*06042
524
548
549
582
583

DQB1*0606
524
526
549
581

DQB1*0609
524
526
549
582
583

DQB1*06051
524
526
549
582
583

DQB1*0608
524
548
549
582
583

DQB1*0613
526
548
549
582
583

DQB1*0612
524
526
549
582
583

DQB1*0617
524
549
582
583

DQB1*0502
549
584

DQB1*0504
526
549

DQB1*0610
526
548
549
582
583

DQB1*06111
526
548
549
582
583

DQB1*06112
524
526
548
549
582
583

DQB1*0603
524
548
549
582
583

DQB1*0602
526
548
549
582
583

DQB1*0616
526
548
549
570
582
583

DQB1*0614
524
548
549
582
583

DQB1*0615
526
548
549
582
583

DQB1*0607
524
548
549
582
583

DQB1*0304
526
538
549
582
583

DQB1*06052
524
526
549
582
583

[0171]

24

TABLE 24

Correspondence of the patchworks and SEQ ID Nos for DQB1

patchwork
SEQ ID NO:

DQB1
507

DQB2
508

DQB3
509

DQB4
510

DQB5
511

DQB6
512

DQB7
517
520
522

DQB8
518
521
523

DQB9
519

DQB10
533
536
537

DQB11
534

DQB12
535

DQB13
540
543
544
545
546
547

DQB14
541

DQB15
542

DQB16
559

DQB17
560

DQB18
561
565
568
569

DQB19
562
566

DQB20
563
567

DQB21
564

DQB22
572

DQB23
573

DQB24
574

DQB25
575

DQB26
576

DQB27
577
579

DQB28
578

DQB29
586

DQB30
587

DQB31
588

DQB32
589

DQB33
528
532

DQB34
554
557

DQB35
555
558

[0172]

25

TABLE 25

Correspondence of the patchwork regions and satellite regions for types of DRB1

patchwork region
satellite region

DRB1*0101
D1
D4
DD11
D13
D18
D23
D29
D31
D48
D51
D59
D63
D70
D73

DRB1*0419
D1
D5
D10
D16
D23
D29
D31
D48
D51
D59
D63
D70
D73

DRB1*0105
D1
D4
DD11
D13
D18
D23
D29
D31
D48
D51
D59
D63
D70
D73

688

DRB1*01021
D1
D4
DD11
D13
D18
D23
D29
D31
D48
D51
D59
D63
D71
D74

791

DRB1*0104
D1
D4
DD11
D13
D18
D23
D29
D31
D48
D51
D59
D63
D70
D74

783

DRB1*01022
D1
D4
DD11
D13
D18
D23
D29
D31
D48
D51
D59
D69
D71
D74

791

DRB1*0406
D1
D5
D10
D16
D23
D29
D31
D48
D51
D59
D65
D70
D74

DRB1*0420
D1
D5
D10
D16
D23
D29
D31
D48
D51
D59
D65
D70
D73

DRB1*0106
D1
D4
DD11
D13
D18
D23
D29
D31
D48
D57
D59
D63
D70
D74

DRB1*0304
D1
D6
D10
D14
D19
D23
D30
D31
D48
D56
D59
D66
D70
D74

782

DRB1*0421
D1
D5
D10
D16
D23
D29
D31
D48
D56
D59
D63
D70
D73

DRB1*03021
D1
D5
D11
D14
D19
D24
D29
D31
D48
D56
D59
D66
D70
D73

782

DRB1*0303
D1
D5
D11
D14
D19
D24
D29
D31
D48
D56
D59
D66
D70
D74

782

DRB1*0306
D1
D6
D10
D14
D19
D24
D29
D31
D48
D56
D59
D66
D70
D74

782

DRB1*0305
D1
D6
D10
D14
D19
D24
D30
D31
D48
D56
D59
D66
D70
D73

782

DRB1*0309
D1
D6
D10
D14
D21
D24
D30
D31
D48
D56
D59
D66
D70
D73

782

DRB1*0307
D1
D5
D10
D14
D19
D24
D30
D31
D48
D56
D59
D66
D70
D74

782

DRB1*03011
D1
D6
D10
D14
D19
D24
D30
D31
D48
D56
D59
D66
D70
D74

782

DRB1*0311
D1
D6
D10
D14
D19
D24
D30
D31
D48
D56
D59
D67
D70
D74

782

DRB1*03012
D1
D6
D10
D14
D19
D24
D30
D31
D48
D56
D59
D66
D70
D74

783

DRB1*0314
D1
D6
D10
D14
D19
D24
D30
D31
D48
D56
D59
D66
D70
D73

DRB1*0316
D1
D6
D10
D14
D19
D24
D30
D31
D48
D56
D59
D66
D70
D74

782
699

DRB1*0315
D1
D6
D10
D14
D19
D24
D30
D31
D48
D56
D59
D66
D70
D74

DRB1*1421
D1
D5
D10
D14
D19
D24
D30
D31
D48
D56
D59
D63
D70
D74

DRB1*03022
D1
D5
D11
D14
D19
D24
D29
D31
D48
D56
D59
D66
D70
D73

783

DRB1*1419
D1
D5
D11
D14
D19
D24
D29
D31
D48
D56
D59
D63
D70
D73

DRB1*1320
D1
D5
D10
D14
D19
D24
D30
D31
D48
D52
D59
D63
D70
D74

DRB1*1329
D1
D5
D10
D14
D19
D24
D30
D31
D48
D52
D59
D63
D70
D73

DRB1*1412
D1
D5
D11
D14
D19
D24
D29
D31
D48
D54
D59
D64
D70
D74

DRB1*1403
D1
D5
D11
D14
D19
D24
D29
D31
D48
D54
D59
D64
D70
D73

DRB1*1406
D1
D5
D11
D14
D19
D24
D29
D31
D48
D51
D59
D63
D70
D74

DRB1*1417
D1
D5
D10
D14
D19
D24
D30
D31
D48
D51
D59
D63
D70
D74

DRB1*1433
D1
D5
D10
D14
D19
D24
D30
D31
D48
D51
D59
D65
D70
D74

DRB1*1430
D1
D5
D10
D14
D19
D24
D30
D31
D48
D51
D59
D63
D70
D73

DRB1*1429
D1
D5
D11
D14
D19
D24
D29
D31
D48
D51
D59
D63
D70
D74

791

DRB1*1402
D1
D5
D11
D14
D19
D24
D29
D31
D48
D51
D59
D63
D70
D73

DRB1*1409
D1
D5
D10
D14
D19
D24
D29
D31
D48
D51
D59
D63
D70
D73

DRB1*04031
D1
D5
D10
D16
D25
D29
D31
D48
D51
D59
D65
D70
D74

DRB1*0407
D1
D5
D10
D16
D25
D29
D31
D48
D51
D59
D65
D70
D73

DRB1*0427
D1
D5
D10
D16
D25
D29
D31
D48
D51
D59
D65
D70
D74

791

DRB1*0404
D1
D5
D10
D16
D25
D29
D31
D48
D51
D59
D63
D70
D74

DRB1*0408
D1
D5
D10
D16
D25
D29
D31
D48
D51
D59
D63
D70
D73

DRB1*0423
D1
D5
D10
D16
D25
D29
D31
D48
D51
D59
D63
D70
D74

799

DRB1*0432
D1
D5
D10
D16
D25
D29
D31
D48
D51
D59
D63
D70
D74

751

DRB1*0431
D1
D5
D10
D16
D25
D29
D31
D48
D51
D59
D64
D70
D73

DRB1*1344
D1
D5
D10
D13
D18
D25
D30
D31
D48
D51
D59
D63
D70
D74

DRB1*0317
D1
D5
D10
D13
D18
D25
D29
D31
D48
D56
D59
D67
D70
D73

699
783

DRB1*04011
D1
D5
D10
D16
D25
D29
D31
D48
D56
D59
D63
D70
D73

DRB1*04012
D1
D5
D10
D16
D25
D29
D31
D48
D56
D59
D63
D70
D73

665

DRB1*0413
D1
D5
D10
D16
D25
D29
D31
D48
D56
D59
D63
D70
D74

DRB1*0422
D1
D5
D10
D16
D25
D29
D31
D48
D56
D59
D66
D70
D74

782

DRB1*0433
D1
D5
D10
D16
D25
D29
D31
D48
D56
D59
D63
D70
D73

684

DRB1*0434
D1
D5
D10
D16
D25
D29
D31
D48
D56
D59
D63
D70
D73

DRB1*0435
D1
D5
D10
D16
D25
D30
D31
D48
D56
D59
D63
D70
D73

DRB1*0813
D2
D5
D10
D13
D18
D25
D29
D31
D48
D54
D59
D64
D70
D73

DRB1*1325
D1
D5
D10
D13
D18
D25
D30
D31
D48
D54
D59
D63
D70
D73

DRB1*10011
D1
D4
DD11
D17
D22
D25
D29
D31
D48
D55
D62
D63
D70
D73

752

DRB1*10012
D1
D4
DD11
D17
D22
D25
D29
D31
D48
D55
D60
D63
D70
D73

753

DRB1*1414
D1
D5
D10
D14
D19
D26
D29
D31
D48
D55
D59
D65
D71
D73

DRB1*1436
D1
D5
D10
D14
D19
D26
D29
D31
D48
D55
D59
D65
D71
D73

686

DRB1*1423
D1
D5
D10
D14
D19
D26
D29
D31
D48
D55
D59
D65
D71
D74

DRB1*1420
D1
D5
D11
D14
D19
D26
D29
D31
D48
D51
D59
D63
D70
D74

DRB1*0103
D1
D4
DD11
D13
D18
D23
D29
D31
D49
D52
D59
D63
D70
D73

DRB1*15022
D1
D5
D10
D15
D20
D23
D30
D31
D49
D57
D59
D63
D70
D73

DRB1*1301
D1
D5
D10
D14
D19
D24
D30
D31
D49
D52
D59
D63
D70
D74

DRB1*1327
D1
D6
D10
D14
D19
D24
D30
D31
D49
D52
D59
D63
D70
D74

DRB1*1315
D1
D5
D11
D14
D19
D24
D30
D31
D49
D52
D59
D63
D70
D74

DRB1*1328
D1
D5
D10
D14
D19
D24
D30
D31
D49
D52
D59
D63
D70
D74

789

DRB1*1340
D1
D5
D10
D14
D19
D24
D29
D31
D49
D52
D59
D63
D70
D74

DRB1*13021
D1
D5
D10
D14
D19
D24
D30
D31
D49
D52
D59
D63
D70
D73

DRB1*13022
D1
D5
D10
D14
D19
D24
D30
D31
D49
D52
D60
D63
D70
D73

DRB1*1334
D1
D5
D10
D14
D19
D24
D30
D31
D49
D52
D59
D63
D70
D73

664

DRB1*1335
D1
D5
D10
D14
D19
D24
D30
D31
D49
D52
D59
D63
D70
D73

687

DRB1*1336
D1
D5
D10
D14
D19
D24
D29
D31
D49
D52
D59
D63
D70
D73

DRB1*1341
D1
D6
D10
D14
D19
D24
D30
D31
D49
D52
D59
D63
D70
D73

DRB1*1316
D1
D5
D10
D14
D19
D24
D30
D31
D49
D52
D59
D63
D70
D75

DRB1*1306
D1
D5
D10
D14
D19
D24
D30
D31
D49
D54
D59
D63
D70
D74

DRB1*1310
D1
D5
D10
D14
D19
D24
D30
D31
D49
D53
D59
D63
D70
D74

DRB1*1424
D1
D5
D11
D14
D19
D24
D29
D31
D49
D57
D59
D63
D70
D73

DRB1*1309
D1
D5
D10
D14
D19
D24
D30
D31
D49
D57
D59
D63
D70
D74

DRB1*0402
D1
D5
D10
D16
D25
D29
D31
D49
D52
D59
D63
D70
D74

DRB1*0414
D1
D5
D10
D16
D25
D29
D31
D49
D52
D59
D63
D70
D73

DRB1*1317
D2
D5
D10
D13
D18
D25
D30
D31
D49
D52
D59
D63
D70
D74

DRB1*1322
D1
D5
D10
D13
D18
D25
D30
D31
D49
D52
D59
D63
D70
D74

DRB1*1323
D1
D5
D10
D13
D18
D25
D30
D31
D49
D52
D59
D63
D70
D73

DRB1*0418
D1
D5
D10
D16
D25
D29
D31
D49
D54
D59
D64
D70
D74

DRB1*1337
D1
D5
D10
D13
D18
D25
D29
D31
D49
D53
D59
D63
D70
D73

DRB1*1308
D1
D5
D10
D14
D19
D26
D29
D31
D49
D52
D59
D63
D70
D74

DRB1*1319
D1
D5
D11
D14
D19
D26
D29
D31
D49
D52
D59
D63
D70
D74

DRB1*0425
D1
D5
D10
D16
D25
D29
D31
D50
D54
D59
D64
D70
D74

DRB1*0436
D1
D5
D10
D16
D25
D29
D31
D50
D54
D59
D63
D70
D74

DRB1*08021
D2
D5
D10
D13
D18
D25
D29
D31
D50
D54
D59
D64
D70
D73

DRB1*08022
D2
D5
D10
D13
D18
D25
D29
D31
D50
D54
D59
D64
D70
D73

DRB1*08041
D2
D5
D10
D13
D18
D25
D29
D31
D50
D54
D59
D64
D70
D74

DRB1*08042
*
D5
D10
D13
D18
D25
D29
D31
D50
D54
D59
D64
D70
D75

DRB1*08043
D2
D5
D10
D13
D18
D25
D29
D31
D50
D54
D59
D64
D70
D75

DRB1*0820
D1
D5
D10
D13
D18
D25
D29
D31
D50
D54
D59
D64
D70
D74

DRB1*1311
D1
D5
D10
D13
D18
D25
D30
D31
D50
D54
D59
D63
D70
D74

DRB1*13141
D1
D5
D10
D13
D18
D25
D30
D31
D50
D54
D59
D63
D70
D73

DRB1*1324
D1
D5
D10
D13
D18
D25
D30
D31
D50
D52
D59
D63
D70
D74

DRB1*13071
D1
D5
D10
D13
D18
D25
D29
D31
D50
D53
D59
D63
D70
D73

DRB1*0809
D2
D5
D10
D14
D19
D26
D29
D31
D50
D54
D59
D64
D70
D73

DRB1*0821
D2
D5
D10
D14
D19
D26
D29
D31
D50
D54
D59
D64
D70
D73

DRB1*1415
D2
D5
D10
D14
D19
D26
D29
D31
D50
D54
D59
D64
D70
D74

DRB1*1318
D1
D5
D10
D14
D19
D24
D30
D31
D50
D54
D59
D64
D70
D74

DRB1*1342
D1
D5
D10
D14
D19
D24
D30
D31
D50
D54
D59
D63
D70
D74

DRB1*1427
D1
D5
D11
D14
D19
D24
D29
D31
D50
D54
D59
D64
D70
D73

DRB1*1305
D1
D5
D10
D14
D19
D24
D30
D31
D50
D53
D59
D63
D70
D73

DRB1*0312
D1
D6
D10
D14
D19
D24
D30
D32
D48
D56
D59
D66
D70
D74

782

DRB1*0411
D1
D5
D10
D16
D25
D29
D32
D48
D51
D59
D59
D70
D74

DRB1*0417
D1
D5
D10
D16
D25
D29
D32
D48
D51
D59
D65
D70
D73

DRB1*0410
D1
D5
D10
D16
D25
D29
D32
D48
D51
D59
D63
D70
D74

DRB1*04051
D1
D5
D10
D16
D25
D29
D32
D48
D51
D59
D63
D70
D73

DRB1*04052
D1
D5
D10
D16
D25
D29
D32
D48
D51
D59
D63
D70
D73

685

DRB1*0429
D1
D5
D10
D16
D25
D29
D32
D48
D51
D59
D63
D70
D73

700

DRB1*0430
D1
D5
D10
D16
D25
D29
D32
D48
D51
D59
D63
D70
D73

697

DRB1*0428
D1
D5
D10
D16
D25
D30
D32
D48
D51
D59
D63
D70
D73

DRB1*0409
D1
D5
D10
D16
D25
D29
D32
D48
D56
D59
D63
D70
D73

DRB1*0412
D1
D5
D10
D16
D25
D29
D32
D49
D54
D59
D64
D70
D74

DRB1*0810
D2
D5
D10
D13
D18
D25
D29
D32
D49
D54
D59
D64
D70
D74

DRB1*0812
D2
D5
D10
D13
D18
D25
D29
D32
D49
D54
D59
D64
D70
D74

791

DRB1*08032
D2
D5
D10
D13
D18
D25
D29
D32
D49
D54
D59
D64
D70
D73

DRB1*0814
D2
D5
D10
D13
D18
D25
D29
D32
D49
D54
D59
D64
D70
D73

DRB1*1313
D1
D5
D10
D13
D18
D25
D29
D32
D49
D54
D59
D64
D70
D73

DRB1*0818
D2
D5
D10
D13
D18
D25
D29
D32
D49
D54
D59
D63
D70
D73

DRB1*1312
D1
D5
D10
D13
D18
D25
D29
D32
D49
D54
D59
D63
D70
D73

DRB1*1330
D1
D5
D10
D13
D18
D25
D30
D32
D49
D54
D59
D63
D70
D73

DRB1*13031
D1
D5
D10
D13
D18
D25
D29
D32
D49
D53
D59
D63
D70
D73

DRB1*13032
D1
D5
D10
D13
D18
D25
D29
D32
D49
D53
D59
D63
D70
D73

DRB1*1333
D1
D5
D10
D13
D18
D25
D29
D32
D49
D53
D59
D63
D70
D73

782

DRB1*1304
D1
D5
D10
D13
D18
D25
D30
D32
D49
D52
D59
D63
D70
D74

DRB1*1338
D1
D5
D10
D13
D18
D25
D29
D32
D49
D52
D59
D63
D70
D73

DRB1*1332
D1
D5
D10
D14
D19
D24
D29
D32
D49
D52
D59
D63
D70
D74

DRB1*0801
D2
D5
D10
D13
D18
D25
D29
D32
D50
D54
D59
D64
D70
D73

DRB1*0817
D2
D5
D10
D13
D18
D25
D30
D32
D50
D54
D59
D64
D70
D73

DRB1*0816
D2
D5
D10
D13
D18
D27
D29
D32
D50
D54
D59
D64
D70
D73

DRB1*0806
D2
D5
D10
D13
D18
D25
D29
D32
D50
D54
D59
D64
D70
D74

DRB1*0822
D2
D5
D10
D13
D18
D25
D29
D32
D50
D54
D59
D64
D70
D74

791

DRB1*0805
D2
D5
D10
D13
D18
D25
D29
D32
D50
D54
D59
D63
D70
D73

DRB1*1321
D1
D5
D10
D13
D18
D25
D30
D32
D50
D54
D59
D63
D70
D73

DRB1*1413
D1
D5
D11
D14
D19
D24
D29
D32
D48
D51
D59
D63
D70
D73

DRB1*0308
D1
D6
D10
D14
D19
D24
D30
D43
D48
D56
D59
D66
D70
D74

782

DRB1*1107
D1
D5
D10
D13
D18
D25
D30
D43
D48
D56
D59
D66
D70
D74

782

DRB1*11081
D1
D5
D10
D13
D18
D25
D30
D43
D48
D54
D59
D63
D70
D73

DRB1*11082
D1
D5
D10
D13
D18
D25
D30
D43
D48
D54
D59
D63
D70
D73

DRB1*1136
D1
D5
D10
D13
D18
D25
D30
D43
D48
D52
D59
D63
D70
D74

DRB1*1126
D1
D5
D10
D13
D18
D25
D30
D43
D48
D51
D59
D63
D70
D73

DRB1*1134
D1
D5
D10
D13
D18
D25
D30
D43
D48
D51
D59
D63
D70
D74

DRB1*1113
D1
D5
D10
D14
D19
D26
D30
D43
D48
D55
D59
D63
D71
D74

DRB1*1117
D1
D5
D10
D14
D19
D26
D29
D43
D48
D55
D59
D65
D71
D74

DRB1*11011
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D73

DRB1*11012
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D73

DRB1*11013
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D60
D63
D70
D73

DRB1*11271
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D73

783

DRB1*11272
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D73

782

DRB1*1130
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D73

594

DRB1*1105
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D73

597

DRB1*1137
D1
D5
D10
D13
D18
D25
D29
D43
D50
D54
D59
D63
D70
D73

DRB1*0415
D1
D5
D10
D16
D25
D29
D43
D50
D54
D59
D63
D70
D74

DRB1*1122
D1
D5
D10
D15
D20
D25
D30
D43
D50
D54
D59
D63
D70
D73

DRB1*1139
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D73

699

DRB1*1123
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D64
D70
D73

DRB1*1132
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D68
D70
D73

DRB1*1125
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D64
D70
D74

DRB1*1106
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D74

791

DRB1*11041
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D74

DRB1*11042
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D74

DRB1*1111
D1
D5
D10
D13
D18
D25
D30
D43
D50
D52
D59
D63
D70
D73

DRB1*1141
D1
D5
D10
D13
D18
D25
D29
D43
D50
D52
D59
D63
D70
D74

DRB1*1103
D1
D5
D10
D13
D18
D25
D30
D43
D50
D53
D59
D63
D70
D74

DRB1*1109
D1
D5
D10
D14
D19
D24
D30
D43
D50
D54
D59
D63
D70
D73

DRB1*1128
D1
D5
D10
D13
D18
D24
D30
D43
D50
D54
D59
D63
D70
D73

DRB1*1110
D1
D5
D10
D14
D19
D26
D30
D43
D50
D54
D59
D63
D70
D73

DRB1*11121
D1
D5
D10
D13
D18
D26
D30
D43
D50
D54
D59
D63
D70
D73

DRB1*1115
D1
D5
D10
D13
D18
D27
D30
D43
D50
D54
D59
D63
D70
D73

666

DRB1*1124
D1
D5
D10
D13
D18
D27
D30
D43
D50
D54
D59
D63
D70
D73

DRB1*1129
D1
D5
D10
D13
D18
D23
D30
D43
D50
D54
D59
D63
D70
D73

DRB1*1119
D1
D5
D10
D13
D18
D25
D30
D43
D49
D54
D59
D63
D70
D73

DRB1*1118
D1
D5
D10
D13
D18
D25
D30
D43
D49
D54
D59
D63
D70
D74

DRB1*1114
D1
D5
D10
D13
D18
D25
D30
D43
D49
D52
D59
D63
D70
D73

DRB1*1102
D1
D5
D10
D13
D18
D25
D30
D43
D49
D52
D59
D63
D70
D74

DRB1*1121
D1
D5
D10
D13
D18
D25
D30
D43
D49
D52
D59
D63
D70
D74

791

DRB1*1120
D1
D5
D10
D14
D19
D24
D30
D43
D49
D52
D59
D63
D70
D73

DRB1*1116
D1
D5
D10
D14
D19
D24
D30
D43
D49
D52
D59
D63
D70
D74

DRB1*1204
D2
D8
D11
D14
D19
D28
D30
D43
D49
D54
D60
D63
D71
D74
D76
791

DRB1*1131
D1
D5
D10
D13
D18
D25
D30
D43
D49
D54
D59
D63
D70
D73

718

DRB1*1133
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D73

716

DRB1*1135
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D74

716

DRB1*1138
D1
D5
D10
D13
D18
D25
D30
D43
D50
D54
D59
D63
D70
D74

715

DRB1*1201
D2
D8
D11
D14
D19
D28
D30
D45
D49
D54
D60
D63
D71
D74
D76
791

DRB1*1206
D2
D8
D11
D14
D19
D28
D30
D45
D49
D54
D60
D63
D71
D74
D76
791

DRB1*12032
D2
D8
D11
D14
D19
D28
D30
D45
D49
D54
D60
D63
D70
D74
D76

DRB1*1205
D2
D8
D11
D14
D19
D26
D30
D45
D49
D54
D60
D63
D71
D74
D76
791

DRB1*12021
D2
D8
D11
D14
D19
D28
D30
D45
D50
D54
D60
D63
D71
D74
D76
791

DRB1*12022
D2
D8
D11
D14
D19
D28
D30
D45
D50
D54
D60
D63
D70
D74
D76
791

DRB1*07011
D1
D5
DD11
D15
D20
D26
D29
D45
D49
D58
D59
D67
D72
D73

DRB1*07012
D1
D5
DD11
D15
D20
D26
D29
D45
D49
D58
D59
D67
D72
D73

595

DRB1*0703
D1
D5
DD11
D15
D20
D26
D29
D45
D49
D58
D59
D67
D72
D73

631

DRB1*0704
D1
D5
DD11
D15
D20
D26
D29
D45
D49
D58
D59
D67
D70
D73

783

DRB1*04032
D1
D5
D10
D16
D25
D29
D33
D48
D51
D59
D65
D70
D74

DRB1*1505
D1
D5
D10
D15
D20
D23
D30
D33
D48
D57
D59
D63
D70
D74

DRB1*1506
D1
D5
D10
D15
D20
D23
D30
D33
D48
D57
D59
D63
D70
D74

698

DRB1*16021
D1
D5
D10
D15
D20
D23
D29
D33
D48
D54
D60
D63
D70
D73

DRB1*16022
D1
D5
D10
D15
D20
D23
D29
D33
D48
D54
D59
D63
D70
D73

DRB1*13072
D1
D5
D10
D13
D18
D25
D29
D33
D50
D53
D59
D63
D70
D73

DRB1*13142
D1
D5
D10
D13
D18
D25
D30
D33
D50
D54
D59
D63
D70
D73

DRB1*1326
D1
D5
D10
D14
D19
D24
D29
D33
D50
D54
D60
D63
D70
D73

DRB1*1608
D1
D5
D10
D15
D20
D24
D29
D33
D50
D54
D60
D63
D70
D73

DRB1*16011
D1
D5
D10
D15
D20
D23
D29
D33
D50
D54
D60
D63
D70
D73

DRB1*16012
D1
D5
D10
D15
D20
D23
D29
D33
D50
D54
D59
D63
D70
D73

DRB1*1603
D1
D5
D10
D15
D20
D23
D29
D33
D50
D54
D61
D63
D70
D73

DRB1*1604
D1
D5
D10
D15
D20
D23
D29
D33
D50
D54
D59
D64
D70
D73

DRB1*1504
D1
D5
D10
D15
D20
D23
D30
D33
D50
D57
D59
D63
D70
D74

DRB1*15011
D1
D5
D10
D15
D20
D23
D30
D33
D49
D57
D59
D63
D70
D74

DRB1*15012
D1
D5
D10
D15
D20
D23
D30
D33
D49
D57
D59
D63
D70
D74

790

DRB1*1503
D1
D5
D10
D15
D20
D23
D30
D33
D49
D57
D59
D63
D70
D74

632

DRB1*1509
D1
D5
D10
D15
D20
D23
D30
D33
D49
D57
D59
D63
D70
D74

696

DRB1*1507
D1
D5
D10
D15
D20
D23
D29
D33
D49
D57
D59
D63
D70
D74

DRB1*15021
D1
D5
D10
D15
D20
D23
D30
D33
D49
D57
D59
D63
D70
D73

DRB1*15023
D1
D5
D10
D15
D20
D23
D30
D33
D49
D57
D59
D63
D70
D73

DRB1*1508
D1
D5
D10
D15
D20
D23
D30
D33
D49
D57
D59
D63
D70
D73

725

DRB1*1110
D1
D5
D10
D15
D20
D23
D30
D33
D49
D52
D59
D63
D70
D74

DRB1*1605
D1
D5
D10
D15
D20
D23
D29
D33
D49
D54
D60
D63
D70
D73

DRB1*1607
D1
D5
D10
D15
D20
D23
D29
D33
D49
D54
D60
D63
D70
D73

618

DRB1*0416
D1
D5
D10
D16
D25
D29
D44
D48
D56
D59
D63
D70
D73

DRB1*0426
D1
D5
D10
D16
D25
D29
D41
D48
D56
D59
D63
D70
D73

DRB1*0807
D2
D5
D10
D13
D18
D25
D29
D38
D50
D54
D59
D64
D70
D73

DRB1*0811
D2
D5
D10
D13
D18
D25
D29
D38
D50
D54
D59
D64
D70
D73

DRB1*0815
D2
D5
D10
D13
D18
D25
D29
D42
D49
D54
D59
D64
D70
D73

717

DRB1*0819
D2
D5
D10
D13
D18
D25
D29
D40
D49
D54
D59
D64
D70
D73

DRB1*09012
D1
D7
D12
D13
D18
D24
D29
D38
D50
D55
D59
D65
D72
D73

DRB1*0808
D2
D5
D10
D13
D18
D25
D29
D36
D50
D54
D59
D64
D70
D73

DRB1*14011
D1
D5
D10
D14
D19
D26
D29
D36
D48
D55
D59
D65
D71
D74

DRB1*1407
D1
D5
D10
D14
D19
D26
D29
D36
D48
D55
D59
D65
D71
D73

DRB1*1410
D1
D5
D10
D14
D19
D26
D29
D36
D48
D55
D59
D65
D71
D74

596

DRB1*1426
D1
D5
D10
D14
D19
D26
D29
D36
D48
D55
D59
D65
D71
D74

608

DRB1*1404
D2
D5
D10
D14
D19
D26
D29
D36
D48
D55
D59
D65
D71
D74

DRB1*1428
D2
D5
D10
D14
D19
D26
D29
D36
D48
D55
D59
D65
D71
D74

791

DRB1*1431
D2
D5
D10
D14
D19
D26
D29
D36
D48
D55
D59
D63
D71
D74

DRB1*1432
D1
D5
D10
D14
D19
D26
D29
D36
D48
D55
D59
D63
D70
D74

DRB1*1435
D1
D5
D10
D14
D19
D26
D30
D36
D48
D55
D59
D65
D71
D74

DRB1*1343
D1
D5
D10
D14
D19
D24
D30
D36
D48
D52
D59
D63
D70
D74

DRB1*1345
D1
D5
D10
D13
D18
D25
D30
D36
D49
D52
D59
D63
D70
D73

DRB1*1416
D1
D5
D10
D14
D19
D26
D29
D36
D49
D52
D59
D63
D70
D74

DRB1*0310
D1
D6
D10
D14
D19
D24
D30
D36
D48
D56
D59
D66
D70
D74

782

DRB1*1422
D1
D5
D10
D14
D19
D26
D29
D36
D50
D54
D59
D63
D70
D73

DRB1*1425
D1
D5
D10
D13
D18
D25
D29
D36
D50
D54
D59
D63
D70
D73

DRB1*1331
D1
D5
D10
D14
D19
D24
D30
D34
D49
D52
D59
D63
D70
D73

DRB1*1339
D1
D5
D10
D14
D19
D24
D30
D35
D49
D52
D59
D63
D70
D73

DRB1*0313
D1
D6
D10
D14
D19
D24
D30
D35
D48
D56
D59
D66
D70
D74

782

DRB1*1408
D1
D5
D10
D14
D19
D26
D29
D46
D48
D55
D59
D65
D71
D74

DRB1*1411
D2
D5
D10
D14
D19
D26
D29
D47
D48
D55
D59
D65
D71
D74

DRB1*1418
D1
D5
D11
D14
D19
D24
D29
D37
D48
D55
D59
D65
D71
D74

DRB1*1405
D3
D5
D10
D14
D19
D26
D29
D37
D48
D55
D59
D65
D71
D74

DRB1*1437
D3
D5
D10
D14
D19
D26
D29
D37
D49
D57
D59
D63
D70
D74

DRB1*1434
D1
D5
D10
D14
D19
D26
D29
D46
D48
D55
D59
D63
D71
D74

[0173]

26

TABLE 26

Correspondence of the patchworks and SEQ ID Nos for DRB1

Patchwork
SEQ ID NO:

D1
600
603
604
605
606
607

D2
601

D3
602

D4
609

D5
610
614
615
616
617

D6
611

D7
612

D8
613

D9
619
623
626
627

D10
620
624
627
629
630

D11
621
625

D12
622

D13
633
643
650

D14
635
645

D15
637
647
653
657
661

D16
639
649

D17
641

D18
634
644
651
655
659
663

D19
636
646
652
656
660

D20
638
648
654
658
662

D21
640

D22
642

D23
667
673

D24
668
674
678

D25
669
675
679
681
682
683

D26
670
676
680

D27
671
677

D28
672

D29
689
691
693
695

D30
690
692
694

D31
701

D32
702

D33
703

D34
704

D35
705

D36
706

D37
707

D38
708

D39
709

D40
710

D41
711

D42
712

D43
713
722
723
724

D44
714

D45
719

D46
720

D47
721

D48
726
729

D49
727
730
732

D50
728
731

D51
733
741

D52
734
742

D53
735
743

D54
736
744

D55
737
745
747

D56
738
746

D57
739

D58
740

D59
748
754
756
758
759
760
761
762
763
764
765
767
768
769
770

D60
749
755
757

D61
750

D62
752

D63
771
778
779
780
781

D64
772

D65
773

D66
774

D67
775

D68
776

D69
777

D70
784
787
788

D71
785

D72
786

D73
792

D74
793
795
796
797
798

D75
794

D76
597
598
599

[0174]

27

TABLE 27

Correspondence of the patchwork regions and satellite regions for types of DRB 3-5

patchwork
satellite

DRB3*01011
R1
R3
R7
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R45
R50
R52
832

DRB3*0101201
R1
R3
R7
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R45
R50
R52
832

DRB3*0101202
R1
R3
R7
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R45
R50
R52
832

DRB3*01014
R1
R3
R7
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R45
R50
R52
832
847

DRB3*0102
R1
R3
R7
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R45
R50
R52
832
853

DRB3*0103
R1
R3
R8
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R45
R50
R52
832

DRB3*0104
R1
R3
R7
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R45
R50
R52
832
852

DRB3*0105
R1
R3
R10
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R45
R50
R52
832

DRB3*0106
R1
R3
R7
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R45
R50
R52

DRB3*0209
R1
R2
R8
R16
R19
R21
R24
R27
R31
R32
R34
R40
R43
R46
R50
R52
832

DRB3*0301
R1
R2
R8
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R46
R50
R53

DRB3*03012
R1
R2
R8
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R46
R50
R53
832

DRB3*0302
R1
R2
R8
R16
R19
R21
R25
R27
R31
R32
R34
R40
R43
R46
R50
R53

DRB3*0303
R1
R2
R8
R17
R19
R21
R25
R27
R31
R32
R34
R40
R43
R45
R50
R52

DRB3*01013
R1
R3
R7
R17
R19
R21
R25
R27
R32
R33
R34
R40
R43
R45
R50
R52
832

DRB3*0107
R1
R3
R7
R17
R19
R21
R24
R27
R28
R34
R40
R43
R46
R50
R52

834
847

DRB3*02022
R1
R2
R8
R16
R19
R21
R24
R27
R28
R34
R40
R43
R46
R50
R52

834
847

DRB3*02010
R1
R2
R8
R16
R19
R21
R24
R27
R28
R34
R40
R43
R46
R50
R52

832

DRB3*02012
R1
R2
R8
R16
R19
R21
R24
R27
R28
R34
R40
R43
R46
R50
R52

832
847

DRB3*0205
R1
R2
R8
R17
R19
R21
R24
R27
R28
R34
R40
R43
R46
R50
R52

832
847

DRB3*02021
R1
R2
R8
R16
R19
R21
R24
R27
R28
R34
R40
R43
R46
R50
R52

834
847

DRB3*02011
R1
R2
R8
R16
R19
R21
R24
R27
R28
R35
R40
R43
R46
R50
R52

832
847

DRB3*02023
R1
R2
R8
R16
R19
R21
R24
R27
R28
R34
R40
R43
R46
R50
R52

834
847
845

DRB3*0201
R1
R2
R8
R16
R19
R21
R24
R27
R28
R34
R40
R43
R46
R50
R53

834
847

DRB3*0203
R1
R2
R8
R16
R19
R21
R22
R27
R28
R34
R40
R43
R46
R50
R52

847

DRB3*0206
R1
R2
R8
R16
R19
R21
R23
R27
R28
R34
R40
R43
R46
R50
R52

832
847

DRB3*0204
R1
R2
R8
R16
R19
R21
R24
R27
R28
R34
R40
R43
R45
R50
R52

832
847

DRB3*02013
R1
R4
R8
R16
R19
R21
R24
R27
R28
R34
R40
R43
R46
R50
R52

832
847

DRB3*0207
R1
R2
R8
R16
R19
R21
R24
R27
R31
R34
R40
R43
R46
R50
R52

832
847

DRB3*0208
R1
R2
R8
R16
R19
R21
R24
R27
R29
R34
R40
R43
R46
R50
R52

832
847

DRB4*0103101
R1
R5
R10
R14
R18
R20
R24
R27
R30
R34
R39
R43
R48
R50
R53

DRB4*01032
R1
R5
R10
R14
R18
R20
R24
R27
R30
R34
R39
R43
R48
R50
R53

DRB4*01011
R1
R5
R10
R14
R18
R20
R24
R27
R30
R34
R39
R43
R48
R50
R53

DRB4*01033
R1
R5
R10
R14
R18
R20
R24
R27
R30
R34
R39
R43
R48
R51
R53

DRB4*0102

R5
R10
R14
R18
R20
R24
R27
R30
R34
R39
R43
R48
R50
R53

843

DRB4*0104
R1
R5
R10
R14
R18
R20
R24
R27
R30
R34
R39
R43
R48
R50
R53

844

DRB4*0105
R1
R5
R10
R14
R18
R20
R24
R27
R30
R34
R39
R43
R48
R50
R53

DRB4*0201N
R1
R6
R11
R14
R18
R20
R24
R27
R30
R34
R39
R43
R48
R50
R53

DRB5*01011
R1
R2
R12
R15
R18
R20
R26
R27
R30
R36
R38
R44
R49
R50
R52

833

DRB5*01012
R1
R2
R12
R15
R18
R20
R26
R27
R30
R36
R38
R43
R49
R50
R52

833

DRB5*0105
R1
R2
R12
R15
R18
R20
R26
R27
R30
R36
R38
R44
R49
R50
R52

DRB5*0104
R1
R2
R12
R15
R18
R20
R26
R27
R30
R36
R38
R43
R47
R50
R52

DRB5*0106
R1
R2
R12
R15
R18
R20
R26
R27
R30
R35
R41
R43
R49
R50
R53

DRB5*0107
R1
R2
R12
R15
R18
R20
R26
R27
R30
R35
R38
R44
R49
R50
R52

DRB5*0109
R1
R2
R12
R15
R18
R20
R26
R27
R30
R36
R42
R44
R49
R50
R52

DRB5*0108N
R1
R2
R12
R13
R18
R20
R23
R27
R30
R36
R38
R44
R49
R50
R52

DRB5*0102
R1
R2
R12
R13
R18
R20
R23
R27
R30
R36
R38
R44
R49
R50
R52

DRB5*0110N
R1
R2
R12
R13
R18
R20
R23
R27
R30
R36
R38
R44
R49
R50
R52

DRB5*0103
R1
R2
R12
R13
R18
R20
R23
R27
R30
R36
R31
R44
R49
R50
R52

DRB5*0202
R1
R2
R12
R13
R18
R20
R23
R27
R30
R35
R41
R43
R49
R50
R53

DRB5*0203
R1
R2
R12
R13
R18
R20
R23
R27
R30
R35
R41
R43
R49
R50
R52

DRB5*0204
R1
R2
R12
R13
R18
R20
R23
R27
R30
R36
R41
R43
R49
R50
R53

848

DRB5*0205
R1
R2
R12
R13
R18
R20
R23
R27
R30
R34
R37
R43
R49
R50
R53

848

[0175]

28

TABLE 28

Correspondence of the patchworks and SEQ ID NOs for DRB 3-5

Patchwork
SEQ ID NO:

R1
603
604
607

R2
610
803

R3
611
804
805

R4
800

R5
801

R6
802

R7
620

R8
621
810
812
813

R9
806

R10
807

R11
808

R12
809
811

R13
814

R14
815

R15
816

R16
817

R17
818
819
820

R18
643
821
822

R19
823
824

R20
825
826
659

R21
827
828
652
829

R22
673

R23
668
678

R24
682
831

R25
676
680

R26
830

R27
689
691

R28
701

R29
702

R30
703

R31
704

R32
837

R33
838

R34
726

R35
727
730

R36
728
731

R37
733

R38
736
744
839

R39
737

R40
746

R41
739

R42
1072

R43
658
659
662
667
841

R44
655
840

R45
774

R46
775

R47
772
842

R48
773

R49
771
780

R50
784
787
788

R51
785

R52
792
850

R53
793
795
851

[0176]

29

TABLE 29

Correspondence of the patchwork regions and satellite regions for types of A

patchwork region

A*01011
1A
6A
9A
14A
19A
25A
29A
33A
36A
45A
47A
52A

A*0106
1A
6A
9A
14A
19A
25A
29A
33A
36A
45A
48A
52A

A*0108
1A
6A
9A
14A
19A
25A
29A
33A
36A
45A
47A
53A

A*3601
1A
6A
9A
14A
19A
25A
29A
33A
36A
45A
47A
54A
64A

A*3602
1A
6A
9A
14A
19A
25A
29A
33A
36A
45A
47A
54A
64A

A*01012
1A
7A
9A
14A
19A
25A
29A
33A
36A
45A
47A
52A

A*0102
3A
7A
9A
14A
19A
25A
29A
33A
36A
45A
47A
52A

A*0107
1A
6A
10A
14A
20A
25A
30A
33A
36A
45A
47A
52A

A*3002
3A
7A
10A
14A
20A
25A
30A
33A
36A
44A
48A
54A
60A
63A
64A
58A

A*3009
3A
7A
10A
14A
20A
25A
30A
33A
36A
44A
48A
54A
60A
61A
64A
58A

A*3003
3A
7A
9A
14A
20A
25A
30A
33A
36A
44A
48A
54A
60A
63A
64A
58A

A*3004
3A
7A
10A
14A
20A
25A
30A
33A
36A
44A
49A
54A
61A
64A

58A

A*3006
3A
7A
10A
14A
20A
25A
30A
33A
36A
44A
49A
54A
61A
64A

58A

A*03011
1A
6A
9A
14A
20A
25A
31A
33A
36A
45A
48A
54A
62A
64A

58A

A*0304
1A
6A
9A
14A
20A
25A
31A
33A
36A
45A
48A
54A
62A
64A

58A

A*0308
1A
6A
9A
14A
20A
25A
31A
33A
36A
45A
48A
54A
62A
64A
58A

A*0305
1A
6A
9A
14A
20A
25A
31A
33A
36A
45A
48A
54A
62A
64A
58A

A*0306
1A
6A
9A
14A
20A
25A
31A
33A
36A
45A
48A
54A
62A
64A
58A

A*0307
1A
6A
9A
14A
20A
25A
31A
33A
36A
45A
48A
54A
61A
64A
58A

A*03013
1A
6A
11A
14A
20A
25A
31A
33A
36A
45A
48A
54A
62A
64A
58A

A*3103
4A
6A
10A
14A
20A
25A
31A
33A
36A
45A
48A
54A
60A
61A
64A
58A

A*3104
4A
6A
10A
14A
20A
25A
31A
33A
36A
45A
48A
54A
60A
61A
64A
58A

A*3001
3A
7A
10A
14A
20A
25A
31A
33A
36A
44A
48A
54A
60A
63A
64A
58A

A*3008
2A
7A
10A
14A
20A
25A
31A
33A
36A
44A
48A
54A
60A
63A
64A
58A

A*03012
1A
6A
9A
14A
20A
25A
31A
33A
36A
45A
51A
54A
62A
64A
58A

A*0302
1A
6A
9A
14A
20A
25A
31A
33A
36A
45A
50A
54A
62A
64A
58A

A*11011
2A
6A
9A
14A
20A
25A
31A
33A
36A
45A
50A
52A
64A

A*11012
2A
6A
9A
14A
20A
25A
31A
33A
36A
45A
50A
52A
64A

A*1102
2A
6A
9A
14A
20A
25A
31A
33A
36A
45A
50A
52A
64A

A*1103
2A
6A
9A
14A
20A
25A
31A
33A
36A
45A
50A
52A
60A
62A
64A

A*1105
2A
6A
9A
14A
20A
25A
31A
33A
36A
45A
50A
52A
64A

A*1106
2A
6A
9A
14A
20A
26A
31A
33A
36A
45A
50A
52A
64A

A*1107
2A
6A
9A
14A
20A
25A
31A
33A
36A
45A
50A
52A
64A

A*1109
2A
6A
9A
14A
20A
25A
31A
33A
36A
45A
50A
52A
64A

A*1104
2A
6A
9A
14A
20A
25A
31A
33A
36A
45A
50A
54A
64A

A*1108
2A
6A
9A
14A
20A
25A
31A
33A
36A
45A
47A
52A
62A
64A

A*3204
1A
6A
9A
14A
20A
25A
32A
33A
36A
45A
48A
54A
62A
64A
58A

A*0103
1A
6A
9A
14A
19A
25A
29A
33A
37A
45A
47A
52A

A*3203
1A
6A
9A
14A
20A
25A
30A
33A
37A
41A
48A
54A
60A
61A
64A

A*31012
4A
6A
10A
14A
20A
25A
31A
33A
37A
41A
48A
54A
60A
61A
64A
58A

A*3105
4A
6A
10A
14A
20A
25A
31A
33A
37A
41A
48A
54A
60A
61A
58A

A*3102
4A
6A
10A
14A
21A
25A
31A
33A
37A
41A
48A
54A
60A
61A
64A
58A

A*7401
1A
6A
9A
14A
20A
25A
31A
33A
37A
41A
48A
54A
60A
61A
64A

A*7402
1A
6A
9A
14A
20A
25A
31A
33A
37A
41A
48A
54A
60A
61A
64A

A*7403
1A
6A
9A
14A
20A
25A
31A
33A
37A
41A
48A
54A
60A
61A
64A

A*7405
1A
6A
9A
14A
20A
25A
31A
33A
37A
41A
48A
54A
60A
61A
64A

A*3202
1A
6A
9A
14A
20A
25A
32A
33A
37A
41A
50A
54A
61A
64A

A*3201
1A
6A
9A
14A
20A
25A
32A
33A
37A
41A
48A
54A
60A
61A
64A

A*3206
1A
6A
9A
14A
20A
25A
32A
33A
37A
41A
48A
54A
61A
64A

A*3205
1A
6A
9A
14A
21A
25A
32A
33A
37A
41A
48A
54A
60A
61A
64A

A*0245
1A
7A
11A
14A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0204
1A
7A
11A
15A
21A
26A
31A
34A
37A
39A
48A
54A
61A
64A

A*02171
1A
7A
11A
15A
21A
26A
31A
35A
37A
39A
48A
54A
61A
64A

A*02172
1A
7A
11A
15A
21A
26A
31A
35A
37A
39A
48A
54A
61A
64A

A*7404
1A
6A
11A
15A
21A
25A
31A
33A
37A
41A
48A
54A
60A
61A
64A

A*2408
3A
6A
9A
15A
21A
25A
30A
35A
37A
39A
50A
54A
61A
58A

A*02012
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*02013
1A
7A
11A
15A
21A
27A
31A
34A
38A
39A
48A
54A
61A
64A

A*02014
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*02015
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0209
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0224
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0236
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A

A*02016
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0207
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0218
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0225
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0226
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
62A
64A

A*0230
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0231
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0233
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0234
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0239
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0240
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
60A
61A
64A

A*0211
1A
7A
11A
15A
21A
25A
31A
34A
38A
39A
48A
54A
61A
64A

A*02201
1A
7A
11A
15A
20A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*02202
1A
7A
11A
15A
22A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0229
1A
7A
11A
15A
23A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0235
1A
7A
11A
15A
21A
25A
31A
34A
38A
39A
48A
54A
61A
64A

A*02011
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
47A
54A
61A
64A

A*0242
1A
8A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0216
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
55A
61A
64A

A*0206
2A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0241
2A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0210
2A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0221
2A
7A
11A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0244
2A
7A
11A
15A
21A
26A
31A
34A
38A
39A
50A
54A
61A
64A

A*0228
2A
7A
12A
15A
21A
26A
31A
34A
38A
39A
48A
54A
61A
64A

A*0214
2A
7A
11A
15A
21A
26A
31A
35A
38A
39A
48A
54A
61A
64A

A*0205
2A
7A
11A
15A
21A
26A
31A
35A
38A
39A
49A
54A
61A
64A

A*0208
2A
7A
11A
15A
20A
26A
31A
35A
38A
39A
49A
54A
61A
64A

A*0202
1A
7A
11A
15A
21A
26A
31A
35A
38A
39A
49A
54A
61A
64A

A*0247
1A
7A
11a
15A
21A
26A
31A
35A
38A
39A
49A
54A
61A
64A

A*0203
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
49A
54A
62A
64A

A*0222
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
49A
54A
61A
64A

A*0212
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
50A
54A
61A
64A

A*0213
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
50A
54A
62A
64A

A*0219
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
50A
54A
61A

A*0227
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
50A
54A
64A

A*0237
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
50A
54A
61A

A*0238
1A
7A
11A
15A
21A
26A
31A
34A
38A
39A
50A
52A
62A
64A

A*2607
2A
6A
9A
15A
21A
25A
29A
33A
38A
41A
49A
52A
62A
64A

A*3007
3A
7A
10A
16A
21A
25A
30A
33A
36A
44A
48A
54A
57A
58A
60A
63A
64A

A*8001
1A
7A
13A
16A
20A
28A
29A
33A
36A
45A
49A
55A
58A
60A
63A

A*2404
3A
6A
9A
16A
21A
25A
29A
35A
37A
39A
50A
54A
57A
58A
61A

A*2301
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
48A
54A
57A
58A
60A
61A

A*2303
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
48A
54A
57A
58A
60A
61A

A*2304
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
48A
54A
57A
58A
60A
61A
64A

A*2305
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
48A
54A
57A
58A
60A
61A

A*2306
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
48A
54A
57A
58A
60A
61A

A*2413
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
48A
54A
57A
58A
61A

A*2418
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
48A
54A
57A
58A
62A
64A

A*2302
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
49A
54A
57A
58A
60A
61A

A*2406
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
49A
54A
57A
58A
61A

A*2422
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
49A
54A
57A
58A
61A
64A

A*2402101
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*2402102L
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*24031
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A
64A

A*24022
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*2405
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*2407
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*2415
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
61A

A*2417
3A
6A
9A
16A
21A
25A
30A
35A
37A
45A
50A
54A
57A
58A
61A

A*2420
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*2421
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*2425
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*2426
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*2427
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
59A
61A

A*2429
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
58A
61A

A*2431
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*24032
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A
64A

A*2423
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
54A
57A
58A
61A
64A

A*2410
3A
6A
9A
16A
21A
25A
30A
35A
37A
39A
50A
52A
57A
58A
61A
64A

A*2430
3A
6A
9A
16A
21A
26A
30A
35A
37A
39A
50A
54A
57A
58A
61A

A*2416
4A
6A
9A
16A
21A
25A
30A
33A
37A
41A
48A
54A
57A
58A
60A
61A
64A

A*2419
3A
6A
9A
16A
21A
25A
31A
35A
37A
39A
50A
54A
57A
58A
61A

A*2428
3A
6A
9A
16A
21A
26A
31A
35A
37A
39A
50A
54A
57A
58A
61A

A*6810
2A
6A
9A
16A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*6814
2A
6A
9A
16A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*0246
1A
7A
11A
16A
21A
26A
31A
34A
38A
39A
48A
54A
57A
61A
64A

A*0248
1A
7A
9A
16A
21A
25A
31A
34A
38A
39A
48A
54A
57A
61A
64A

A*2414
3A
6A
9A
16A
21A
25A
30A
34A
38A
39A
50A
54A
57A
58A
61A

A*3402
2A
6A
9A
17A
20A
25A
31A
33A
36A
45A
48A
54A
58A
62A
64A

A*3403
2A
6A
9A
17A
20A
25A
31A
33A
36A
45A
48A
54A
58A
62A
64A

A*2424
3A
6A
9A
17A
20A
25A
30A
35A
37A
39A
48A
54A
58A
60A
61A

A*3301
4A
6A
9A
17A
20A
25A
31A
33A
37A
41A
48A
54A
58A
60A
61A
64A

A*3303
4A
6A
9A
17A
20A
25A
31A
33A
37A
41A
48A
54A
58A
60A
61A
64A

A*3304
4A
6A
9A
17A
20A
25A
31A
33A
37A
41A
48A
54A
58A
60A
61A
64A

A*3305
4A
6A
9A
17A
20A
25A
31A
33A
37A
41A
48A
54A
58A
60A
61A
64A

A*3306
4A
6A
9A
17A
20A
25A
31A
33A
37A
41A
48A
54A
58A
60A
61A
64A

A*68011
2A
6A
9A
17A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*6804
2A
6A
9A
17A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*6813
2A
6A
9A
17A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*6808
2A
6A
9A
17A
20A
25A
31A
33A
37A
45A
51A
54A
58A
61A
64A

A*68012
5A
6A
9A
17A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*6812
5A
6A
9A
17A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*6816
5A
6A
9A
17A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*6817
5A
6A
9A
17A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*6819
5A
6A
9A
17A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*68031
5A
6A
9A
17A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*68032
5A
6A
9A
17A
20A
25A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*6806
5A
6A
9A
17A
20A
25A
31A
33A
37A
44A
49A
54A
58A
61A
64A

A*6807
5A
6A
9A
17A
20A
25A
31A
33A
37A
46A
49A
54A
58A
61A
64A

A*6805
5A
6A
9A
17A
20A
26A
31A
33A
37A
45A
49A
54A
58A
61A
64A

A*6809
5A
6A
9A
17A
20A
25A
31A
33A
37A
45A
50A
54A
58A
61A
64A

A*2501
2A
6A
9A
17A
20A
25A
32A
33A
38A
41A
49A
52A
62A
64A

A*2502
2A
6A
9A
17A
20A
25A
32A
33A
38A
41A
49A
52A
62A
64A

A*2503
1A
6A
9A
17A
20A
25A
32A
33A
38A
41A
49A
52A
62A
64A

A*2601
2A
6A
9A
17A
20A
25A
29A
33A
38A
41A
49A
52A
62A
64A

A*2610
2A
6A
9A
17A
20A
25A
29A
33A
38A
41A
49A
52A
62A
64A

A*2612
2A
6A
9A
17A
20A
25A
29A
33A
38A
41A
49A
52A
61A
64A

A*2613
2A
6A
9A
17A
20A
25A
29A
33A
38A
41A
49A
52A
62A
64A

A*2614
2A
6A
9A
17A
20A
25A
29A
33A
38A
41A
49A
52A
62A
64A

A*2615
2A
6A
9A
17A
20A
25A
29A
33A
38A
41A
49A
52A
62A
64A

A*2617
2A
6A
9A
17A
20A
25A
29A
33A
38A
41A
49A
52A
62A
64A

A*2608
2A
6A
9A
17A
20A
25A
29A
33A
38A
41A
50A
52A
62A
64A

A*2616
3A
6A
9A
17A
20A
25A
29A
33A
38A
41A
49A
52A
62A
64A

A*2602
2A
6A
9A
17A
20A
25A
29A
33A
38A
44A
49A
52A
62A
64A

A*2604
2A
6A
9A
17A
20A
25A
29A
33A
38A
41A
49A
56A
62A
64A

A*2609
2A
6A
9A
17A
20A
25A
29A
33A
38A
41A
49A
54A
62A
64A

A*2605
2A
6A
9A
17A
20A
25A
30A
33A
38A
41A
49A
52A
62A
64A

A*2603
2A
6A
9A
17A
20A
26A
31A
33A
38A
41A
49A
52A
62A
64A

A*2606
2A
6A
9A
17A
20A
26A
31A
33A
38A
45A
49A
52A
62A
64A

A*6601
2A
6A
9A
17A
20A
25A
31A
33A
38A
41A
49A
52A
62A
64A

A*6604
2A
6A
9A
17A
20A
25A
31A
33A
38A
41A
49A
52A
62A
64A

A*3401
2A
6A
9A
17A
21A
25A
31A
33A
38A
41A
49A
54A
62A
64A

A*6602
2A
6A
9A
17A
20A
25A
31A
33A
38A
41A
49A
55A
62A
64A

A*6603
2A
6A
9A
17A
20A
25A
31A
33A
38A
41A
49A
55A
62A
64A

A*6802
2A
6A
9A
17A
20A
25A
31A
33A
38A
39A
49A
54A
61A
64A

A*6815
2A
6A
9A
17A
20A
26A
31A
33A
38A
39A
49A
54A
61A
64A

A*6901
2A
6A
9A
17A
20A
25A
31A
34A
38A
39A
48A
54A
58A
61A
64A

A*2901
4A
6A
9A
18A
20A
25A
29A
33A
37A
45A
48A
54A
58A
60A
61A
64A

A*2902
4A
6A
9A
18A
20A
25A
29A
33A
37A
45A
48A
54A
58A
60A
61A
64A

A*2903
4A
6A
9A
18A
20A
25A
29A
33A
37A
45A
48A
54A
58A
60A
61A

A*2904
4A
6A
9A
18A
24A
25A
29A
33A
37A
45A
48A
54A
58A
60A
61A
64A

A*4301
2A
6A
9A
18A
20A
25A
29A
33A
38A
41A
49A
52A
64A

satellite region

A*01011

A*0106

A*0108

A*3601
1066

A*3602
1056
1066

A*01012

A*0102
919

A*0107
984

A*3002
919
984
1011
1031
1033
1066

A*3009
919
984
1011
1031
1033
1066

A*3003
919
984
1011
1031
1033
1066

A*3004
919
984
1011
1031
1033
1066

A*3006
919
984
1011
1031
1033
1066

A*03011
959
984
1031
1056
1066

A*0304
959
984
1031
1056
1066
1069

A*0308
984
1031
1056
1066

A*0305
959
984
1031
1066

A*0306
959
984
1031
1056
1057
1066

A*0307
959
984
1031
1056
1066

A*03013
959
984
1031
1056
1066

A*3103
961
1031
1033
1066

A*3104
961
984
1031
1033
1066

A*3001
919
959
984
1011
1031
1033
1066

A*3008
908
919
959
984
1011
1031
1033
1066

A*03012
959
984
1031
1056
1066

A*0302
959
984
1031
1056
1066

A*11011
959
1066

A*11012
959
1029
1066

A*1102
920
959
1066

A*1103
959
1066

A*1105
959
1034
1066

A*1106
959
1066

A*1107
959
1009
1066

A*1109
959
1055
1066

A*1104
959
1066

A*1108
959
1066

A*3204
984
1031
1056
1066

A*0103

A*3203
926
984
1026
1031
1033
1066

A*31012
961
984
1026
1031
1033
1066

A*3105
961
984
1026
1031
1033

A*3102
961
984
1026
1031
1033
1066

A*7401
926
984
1026
1031
1033
1066

A*7402
926
984
1026
1031
1033
1066

A*7403
926
982
984
1026
1031
1033
1066

A*7405
926
960
984
1026
1031
1033
1066

A*3202
926
984
1026
1031
1033
1066

A*3201
926
984
1026
1031
1033
1066

A*3206
926
984
1026
1031
1033
1066

A*3205
926
950
984
1026
1031
1033
1066

A*0245
984
1066

A*0204
984
1066

A*02171
984
1004
1066

A*02172
984
1004
1066

A*7404
926
984
1026
1031
1033
1066

A*2408
909
984
1004
1027
1031

A*02012
984
1027
1066

A*02013
984
1027
1035
1066

A*02014
984
1027
1066

A*02015
984
1027
1066

A*0209
984
1027
1066

A*0224
984
1066

A*0236
984
1027

A*02016
984

1027
1066

A*0207
984
1005
1027
1066

A*0218
984
1005
1027
1066

A*0225
984
1027
1035
1066

A*0226
984
1027
1066

A*0230
909
984
1027
1066

A*0231
927
984
1066

A*0233
984
1005
1027
1066

A*0234
959
984
1027
1066

A*0239
984
1004
1027
1066

A*0240
984
1027
1066

A*0211
984
1027
1066

A*02201
984
1027
1066

A*02202
984
1027
1066

A*0229
984
1027
1066

A*0235
959
984
1027
1066

A*02011
961
984
1027
1066

A*0242
984
1027
1066

A*0216
984
1027
1066

A*0206
984
1027
1066

A*0241
984
1027
1066

A*0210
984
1004
1027
1066

A*0221
924
984
1027
1066

A*0244
984
1027
1066

A*0228
984
1027
1066

A*0214
984
1027
1066

A*0205
984
1027
1066

A*0208
984
1027
1066

A*0202
984
1027
1066

A*0247
962
984
1027
1066

A*0203
984
1027
1066

A*0222
984
1027
1066

A*0212
984
1027
1066

A*0213
984
1027
1066

A*0219
984
1027

A*0227
984
1027
1066

A*0237
984
1027

A*0238
984
1027
1035
1066

A*2607
1031
1033
1035
1066

A*3007
919
984
1011
1031
1033
1066

A*8001
1031

A*2404
984
1004
1027
1027
1031

A*2301
984
1004
1027
1027
1031
1033

A*2303
984
1004
1027
1026
1031
1033

A*2304
984
1004
1027
1031
1033
1066

A*2305
911
984
1004
1027
1031
1033

A*2306
983
984
1004
1027
1031
1033

A*2413
984
1004
1027
1031

A*2418
984
1004
1027
1031
1056
1066

A*2302
984
1004
1027
1031
1033

A*2406
984
1004
1027
1031

A*2422
984
1004
1027
1031
1066

A*2402101
984
1004
1027
1031

A*2402102L
984
1004
1027
1031

A*24031
984
1004
1027
1031
1066

A*24022
984
1004
1027

A*2405
984
1004
1027
1031
1033

A*2407
959
984
1004
1027
1031

A*2415
984
1027
1031

A*2417
984
1004
1027
1027
1031

A*2420
909
984
1004
1027
1031

A*2421
984
1004
1027
1031

A*2425
911
984
1004
1027
1031

A*2426
984
1004
1027
1010
1031

A*2427
984
1004
1027
1031

A*2429
984
1004
1027
1031

A*2431
948
984
1004
1027
1031

A*24032
984
1004
1027
1031
1066
1070

A*2423
984
1004
1027
1031

A*2410
984
1004
1027
1031
1066

A*2430
984
1004
1027
1031

A*2416
984
1026
1031
1033
1066

A*2419
959
1004
1027
1031

A*2428
984
1004
1027
1031

A*6810
959
984
1027
1032
1066

A*6814
959
984
1027
1032
1066

A*0246
984
1066

A*0248
984
1066

A*2414
984
1027
1031

A*3402
949
959
1031
1033
1035
1066

A*3403
949
959
1031
1033
1066

A*2424
949
959
984
1004
1027
1031
1033

A*3301
949
961
984
1026
1031
1033
1066
1068

A*3303
949
961
984
1026
1031
1033
1066

A*3304
949
961
984
1026
1028
1031
1033
1066
1068

A*3305
933
949
961
984
1026
1031
1033
1066
1068

A*3306
932
949
961
984
1026
1031
1033
1066

A*68011
949
959
984
1027
1032
1066

A*6804
949
961
984
1027
1032
1066

A*6813
959
984
1027
1032
1066

A*6808
949
959
984
1027
1032
1066

A*68012
949
959
984
1027
1032
1066

A*6812
949
959
984
1027
1066

A*6816
949
959
984
1027
1032
1037
1066

A*6817
949
959
984
1025
1027
1032
1066

A*6819
949
959
984
1027
1032
1056
1066

A*68031
949
984
1027
1032
1066

A*68032
908
949
984
1027
1032
1066

A*6806
949
959
984
1011
1027
1032
1066

A*6807
949
959
984
1027
1032
1066

A*6805
949
1027
1032
1066

A*6809
949
959
984
1027
1032
1066

A*2501
949
1031
1033
1035
1066

A*2502
949
959
1031
1033
1035
1066

A*2503
949
1031
1033
1035
1066

A*2601
949
1031
1033
1035
1066

A*2610
949
1027
1031
1033
1035
1066

A*2612
949
1031
1033
1035
1066

A*2613
949
959
1031
1033
1035
1066

A*2614
949
1031
1033
1066

A*2615
925
949
1031
1033
1035
1066

A*2617
949
985
1031
1033
1035
1066

A*2608
949
1031
1033
1035
1066

A*2616
949
1031
1033
1035
1066

A*2602
949
1031
1033
1035
1066

A*2604
949
1031
1033
1035
1066

A*2609
949
1031
1033
1035
1066

A*2605
949
1031
1033
1035
1066

A*2603
949
1031
1033
1035
1066

A*2606
949
1031
1033
1035
1066

A*6601
949
959
1031
1033
1035
1066

A*6604
949
959
1031
1033
1035
1066
1068

A*3401
949
959
1031
1033
1035
1066

A*6602
949
959
984
1031
1033
1035
1066

A*6603
949
984
1031
1033
1035
1066

A*6802
949
959
984
1027
1032
1066

A*6815
949
984
1027
1032
1066

A*6901
949
959
984
1027
1032
1066

A*2901
926
948
959
984
1006
1026
1031
1033
1066

A*2902
926
948
959
984
1026
1031
1033
1066

A*2903
926
948
959
984
1026
1031
1033

A*2904
926
948
959
984
1026
1031
1033
1066

A*4301
948
1066

[0177]

30

TABLE 30

Correspondence of the patchworks and SEQ ID Nos for A

patchwork
SEQ ID NO.

1A
912

2A
913
917

3A
914
918

4A
915

5A
916

6A
921

7A
922

8A
923

9A
934
939

10A
935
950

11A
936

12A
937

13A
938

14A
941

15A
942
946

16A
943

17A
944
947

18A
945

19A
952

20A
953

21A
954
958

22A
955

23A
956

24A
957

25A
963
967
969
971

26A
964
968
970

27A
965

28A
966

29A
972
976

30A
973
977
979
981

31A
974
978
980

32A
975

33A
986
989
991

34A
987

35A
988
990

36A
992

37A
993
995
997
999

38A
994
996
998
1000
1001
1002

39A
1012
1020

40A
1013
1021

41A
1014

42A
1015
1022

43A
1016

44A
1017
1023

45A
1018
1024

46A
1019

47A
1049
1054

48A
1050

49A
1051

50A
1052

51A
1053

52A
1058
1063

53A
1059

54A
1060
1064
1065

55A
1061

56A
1062

57A
950
951

58A
1007
1008

59A
1030
1041

60A
1036
1042
1046
1048

61A
1038
1043
1047

62A
1039
1044

63A
1040
1045

64A
1067
1071

[0178]

31

TABLE 31

Correspondence of the patchwork regions and satellite regions for types of B

patchwork region

B*35011
2B
7B
12B
15B
20B
24B
29B
38B
43B
47B
51B
53B
54B
58B
59B
62B

B*3524
2B
7B
12B
15B
20B
24B
29B
38B
43B
47B
51B
53B
54B
62B

B*3529
2B
7B
12B
15B
20B
24B
29B
38B
43B
47B
51B
53B
58B
59B
62B

B*3511
2B
7B
12B
15B
20B
24B
29B
38B
43B
47B
61B
53B
54B
58B
59B
62B

B*3514
2B
7B
12B
15B
20B
24B
29B
38B
43B
47B
51B
53B
54B
58B
59B
62B

B*3521
2B
7B
12B
15B
20B
24B
29B
38B
43B
47B
51B
53B
54B
58B
59B
62B

B*35012
2B
7B
12B
15B
20B
24B
29B
38B
43B
47B
51B
53B
54B
58B
59B
62B

B*3505
2B
7B
12B
15B
20B
24B
28B
38B
43B
47B
51B
53B
54B
59B
62B

B*3507
2B
7B
12B
15B
20B
24B
29B
38B
43B
47B
51B
53B
54B
58B
59B
62B

B*3510
2B
7B
12B
15B
20B
24B
29B
38B
43B
47B
51B
52B
53B
54B
58B
59B
62B

B*3523
2B
7B
12B
15B
20B
24B
29B
38B
43B
47B
51B
53B
54B
59B
62B

B*3515
2B
7B
12B
15B
20B
24B
29B
38B
43B
45B
51B
53B
54B
58B
59B
62B

B*3508
2B
7B
12B
15B
20B
24B
29B
38B
41B
47B
51B
53B
54B
58B
59B
62B

B*1522
2B
7B
12B
15B
20B
24B
29B
38B
44B
47B
51B
53B
54B
62B
64B

B*1559
2B
7B
12B
15B
20B
24B
29B
34B
44B
47B
51B
53B
54B
61B
62B
64B

B*35091
2B
7B
12B
15B
20B
24B
29B
34B
43B
47B
51B
53B
54B
58B
59B
61B
62B

B*35092
2B
7B
12B
15B
20B
24B
29B
34B
43B
47B
51B
53B
54B
58B
59B
61B

B*3504
2B
7B
12B
15B
20B
24B
29B
34B
43B
47B
51B
53B
54B
58B
59B
61B
62B

B*3502
2B
7B
12B
15B
20B
24B
29B
34B
43B
47B
51B
53B
54B
58B
59B
61B
62B

B*3512
2B
7B
12B
15B
20B
24B
29B
34B
43B
47B
51B
53B
54B
61B
62B

B*3518
2B
7B
12B
15B
20B
24B
29B
34B
44B
47B
51B
53B
54B
58B
59B
61B

B*3503
2B
7B
12B
15B
20B
24B
29B
40B
43B
47B
51B
53B
54B
58B
59B
62B

B*3506
2B
7B
12B
15B
20B
24B
29B
40B
43B
47B
51B
53B
54B
58B
59B
61B
62B

B*3513
2B
7B
12B
15B
20B
24B
29B
40B
43B
47B
51B
53B
54B
58B
59B
62B

B*3516
2B
7B
12B
15B
20B
24B
28B
38B
43B
47B
51B
53B
54B
62B

B*3517
2B
7B
12B
15B
20B
24B
28B
38B
43B
47B
51B
53B
54B
62B

B*3530
2B
7B
12B
15B
20B
24B
28B
38B
43B
47B
51B
53B
54B
62B

B*3522
2B
7B
12B
15B
20B
24B
28B
34B
41B
47B
51B
53B
54B
61B
62B

B*3531
2B
7B
12B
15B
20B
24B
28B
34B
43B
45B
51B
53B
54B
61B

B*3532
2B
7B
12B
15B
20B
24B
27B
38B
43B
47B
51B
53B
54B
62B

B*3535
2B
7B
12B
15B
20B
24B
27B
38B
43B
46B
51B
53B
54B
58B
59B
62B
63B

B*3534
2B
7B
12B
15B
20B
24B
27B
34B
43B
47B
51B
53B
54B
58B
59B
62B

B*3533
2B
7B
12B
15B
20B
24B
27B
40B
43B
45B
51B
53B
54B
58B
59B
62B

B*3536
2B
7B
12B
15B
20B
24B
27B
40B
43B
47B
51B
53B
54B
58B
59B
62B

B*3537
2B
7B
12B
15B
20B
24B
30B
38B
43B
47B
51B
53B
54B
58B
59B
62B

B*78021
2B
7B
12B
15B
20B
24B
30B
34B
43B
47B
51B
53B
54B
61B
62B

B*7804
2B
7B
12B
15B
20B
24B
308
34B
43B
47B
51B
53B
54B
61B
62B

B*5305
2B
7B
12B
15B
20B
26B
29B
38B
43B
47B
51B
53B
54B
56B
58B
59B
62B

B*3527
2B
7B
12B
15B
21B
24B
29B
38B
43B
47B
51B
53B
54B
58B
59B
62B

B*5304
2B
7B
12B
15B
21B
26B
29B
40B
43B
47B
51B
53B
54B
56B
57B
58B
62B

B*5307
2B
7B
12B
15B
21B
26B
29B
40B
43B
47B
51B
53B
54B
56B
57B
60B
61B
62B

B*5301
2B
7B
12B
15B
21B
26B
29B
38B
43B
47B
51B
53B
54B
56B
57B
58B
59B
62B

B*5302
2B
7B
12B
15B
21B
26B
29B
38B
43B
47B
51B
53B
54B
56B
57B
58B
59B
62B

B*51012
2B
7B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*51022
2B
7B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5105
2B
7B
12B
15B
21B
26B
30B
34B
41B
47B
518
53B
54B
56B
57B
58B
61B
62B

B*5115
2B
7B
12B
15B
21B
26B
30B
35B
43B
47B
51B
53B
54B
56B
57B
61B
62B

B*5303
2B
7B
12B
15B
22B
25B
29B
38B
43B
47B
51B
53B
54B
57B
58B
59B
62B

B*5801
2B
7B
12B
18B
21B
26B
29B
38B
43B
47B
51B
52B
54B
56B
57B
58B
59B
62B

B*5804
2B
7B
12B
18B
21B
26B
29B
36B
43B
47B
51B
52B
54B
56B
57B
58B
59B
62B

B*5805
2B
7B
12B
18B
21B
26B
29B
38B
43B
46B
51B
52B
54B
56B
57B
58B
59B
62B

B*5802
2B
7B
12B
18B
21B
26B
31B
38B
43B
47B
51B
52B
54B
56B
578
58B
59B
62B

B*5806
2B
7B
12B
18B
21B
26B
31B
38B
43B
47B
51B
52B
54B
56B
57B
58B
59B
62B

B*3520
2B
7B
12B
16B
20B
24B
29B
38B
43B
47B
51B
53B
59B
62B

B*3528
2B
7B
12B
16B
20B
24B
29B
38B
43B
47B
51B
52B
53B
54B
58B
59b
62B

B*7805
2B
7B
12B
16B
20B
24B
30B
34B
43B
47B
51B
52B
53B
54B
61B
62B

B*52011
2B
7B
12B
16B
21B
26B
30B
34B
43B
47B
51B
52B
53B
54B
56B
57B
58B
61B
62B

B*52013
2B
7B
12B
16B
21B
26B
30B
34B
43B
47B
52B
53B
54B
56B
57B
58B
61B
62B

B*3526
2B
7B
9B
17B
20B
24B
29B
38B
43B
47B
51B
53B
54B
58B
59B
62B

B*5504
2B
7B
9B
14B
20B
24B
28B
34B
43B
46B
50B
61B

B*5501
2B
7B
9B
14B
20B
24B
30B
35B
43B
46B
50B
61B
62B

B*5502
2B
7B
9B
14B
20B
24B
30B
35B
43B
46B
50B
61B
62B

B*5503
2B
7B
9B
14B
20B
24B
30B
35B
43B
46B
50B
55B
61B
62B

B*5505
2B
7B
9B
14B
20B
24B
30B
35B
43B
46B
50B
61B
62B

B*5601
2B
7B
9B
14B
20B
24B
30B
35B
43B
47B
50B
61B
62B

B*5503
2B
7B
9B
14B
20B
24B
30B
35B
41B
45B
50B
61B
62B

B*5603
2B
7B
9B
14B
20B
24B
29B
38B
44B
47B
62B

B*5508
2B
7B
9B
14B
20B
24B
29B
34B
43B
47B
50B
61B

B*5602
2B
7B
9B
14B
20B
24B
29B
35B
43B
47B
50B
61B
62B

B*5604
2B
7B
9B
14B
20B
24B
29B
35B
43B
47B
50B
61B
62B

B*5607
2B
7B
9B
14B
21B
25B
30B
35B
43B
47B
508
57B
56B
61B
62B

B*5901
2B
7B
9B
15B
21B
26B
30B
35B
43B
46B
50B
53B
54B
56B
57B
58B
59B
61B
62B

B*4601
2B
7B
11B
14B
20B
24B
29B
38B
44B
47B
52B
55B
62B

B*4602
2B
7B
11B
14B
20B
24B
29B
38B
44B
47B
52B
55B
62B

B*15111
2B
7B
11B
14B
20B
24B
29B
38B
44B
47B
53B
54B
62B
64B

B*15112
2B
7B
11B
14B
20B
24B
29B
38B
44B
47B
53B
54B
62B
64B

B*5701
2B
7B
11B
18B
21B
26B
33B
38B
43B
47B
52B
54B
56B
57B
62B

B*5704
2B
7B
11B
18B
21B
26B
33B
36B
41B
47B
52B
54B
56B
57B
60B
62B

B*5702
2B
7B
11B
18B
21B
26B
33B
34B
41B
47B
52B
54B
56B
57B
61B
62B

B*57031
2B
7B
11B
13B
21B
26B
33B
34B
43B
47B
52B
54B
56B
57B
61B
62B

B*57032
2B
7B
11B
18B
21B
26B
33B
34B
43B
47B
52B
54B
56B
57B
61B

B*5705
2B
7B
11B
18B
21B
26B
29B
34B
41B
47B
52B
54B
56B
57B
60B
61B
62B

B*1516
2B
7B
11B
18B
21B
26B
29B
38B
43B
47B
50B
52B
54B
56B
57B
58B
59B
62B
64B

B*1517
2B
7B
11B
18B
21B
26B
29B
36B
43B
47B
52B
54B
56B
57B
62B
64B

B*5706
2B
7B
11B
18B
21B
26B
30B
38B
43B
47B
52B
54B
56B
57B
62B

B*5707
2B
7B
11B
16B
21B
26B
30B
34B
43B
47B
52B
54B
56B
57B
61B
62B

B*1508
2B
7B
11B
15B
20B
24B
29B
38B
44B
47B
53B
54B
62B
64B

B*1556
2B
7B
11B
15B
20B
24B
29B
38B
44B
47B
53B
54B
62B
64B

B*1521
2B
7B
11B
17B
20B
24B
29B
38B
43B
47B
53B
54B
58B
60B
62B
64B

B*1544
2B
7B
11B
17B
20B
24B
29B
38B
43B
46B
53B
54B
58B
60B
62B
64B

B*1513
2B
7B
11B
16B
21B
26B
29B
38B
43B
47B
53B
54B
56B
57B
58B
60B
62B
64B

B*1524
2B
7B
11B
16B
21B
26B
29B
38B
44B
47B
52B
53B
54B
56B
57B
62B
64B

B*1536
2B
7B
11B
16B
21B
25B
29B
38B
43B
47B
52B
53B
54B
56B
57B
58B
60B
62B
64B

B*1557
2B
7B
11B
16B
21B
24B
29B
38B
44B
47B
52B
53B
54B
55B
62B
64B

B*1504
2B
7B
11B
16B
20B
24B
30B
38B
44B
47B
52B
53B
54B
58B
62B
64B

B*1535
2B
7B
11B
16B
20B
24B
30B
38B
44B
47B
52B
53B
54B
62B
64B

B*1542
2B
7B
11B
16B
20B
24B
30B
35B
43B
46B
52B
53B
54B
58B
59B
61B
64B

B*1530
2B
7B
11B
16B
20B
24B
29B
34B
44B
47B
52B
53B
54B
61B
62B
64B

B*1563
2B
7B
11B
16B
20B
24B
29B
34B
44B
47B
52B
53B
54B
62B
64B

B*1548
2B
7B
11B
16B
20B
24B
29B
34B
43B
47B
52B
53B
54B
61B
63B
64B

B*4021
2B
7B
11B
16B
20B
24B
29B
34B
43B
45B
53B
54B
61B

B*1527
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
53B
54B
62B
64B

B*1532
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
62B
64B

B*1515
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
53B
54B
62B
64B

B*1501101
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
62B
64B

B*1512
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
62B
64B

B*1519
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
62B
64B

B*15012
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
62B
64B

B*15013
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
62B
64B

B*15014
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
50B
52B
53B
54B
62B
64B

B*1514
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
62B
64B

B*1528
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
53B
54B
62B
64B

B*1533
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
64B

B*1534
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
64B
59B
62B
64B

B*1538
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
62B
64B

B*1560
2B
7B
11B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
62B
64B

B*1550
2B
7B
11B
16B
20B
24B
29B
38B
44B
46B
52B
53B
54B
62B
64B

B*1525
2B
7B
11B
16B
20B
24B
29B
38B
43B
47B
52B
53B
54B
58B
60B
62B
64B

B*1539
2B
7B
11B
16B
20B
24B
29B
38B
43B
47B
52B
53B
54B
62B
64B

B*1502
2B
7B
11B
16B
20B
24B
29B
38B
43B
47B
53B
54B
58B
60B
62B
64B

B*1505
2B
7B
11B
16B
20B
24B
29B
38B
43B
47B
52B
53B
54B
62B
64B

B*1531
2B
7B
11B
16B
20B
24B
29B
38B
43B
47B
53B
54B
60B
62B
64B

B*1506
2B
7B
11B
16B
20B
24B
29B
38B
43B
47B
52B
53B
54B
60B
62B
64B

B*1520
2B
7B
11B
16B
20B
24B
29B
38B
43B
47B
52B
53B
54B
58B
59B
64B

B*1540
2B
7B
11B
16B
20B
24B
29B
38B
43B
45B
52B
53B
54B
52B
64B

B*1558
2B
7B
11B
16B
20B
24B
29B
40B
44B
47B
52B
53B
54B
61B
62B
64B

B*1507
2B
7B
11B
16B
20B
24B
28B
38B
44B
47B
52B
53B
54B
62B
64B

B*1555
2B
7B
11B
16B
20B
24B
28B
38B
43B
47B
53B
54B
60B
62B
64B

B*1545
2B
7B
11B
16B
20B
24B
28B
34B
44B
47B
52B
53B
54B
62B
64B

B*1543
2B
7B
11B
16B
22B
25B
29B
38B
44B
47B
52B
53B
54B
57B
62B
64B

B*3519
2B
7B
13B
15B
20B
24B
29B
38B
43B
47B
53B
54B
58B
59B
62B

B*4010
2B
7B
13B
16B
20B
24B
29B
34B
43B
45B
50B
52B
53B
54B
61B

B*1546
2B
7B
13B
16B
20B
24B
29B
38B
44B
47B
52B
53B
54B
62B
64B

B*5401
2B
7B
10B
14B
20B
24B
30B
35B
43B
46B
50B
61B
62B

B*5507
2B
7B
10B
14B
20B
24B
30B
35B
43B
46B
50B
61B
62B

B*40011
2B
6B
13B
16B
20B
24B
29B
34B
43B
45B
49B
50B
52B
53B
54B
61B

B*40012
2B
6B
13B
16B
20B
24B
29B
34B
43B
45B
49B
50B
52B
53B
54B
61B

B*4033
2B
6B
13B
16B
20B
24B
29B
34B
43B
45B
49B
50B
52B
53B
54B

B*4014
2B
6B
13B
16B
20B
24B
29B
34B
43B
45B
49B
50B
52B
53B
54B
61B
62B

B*4025
2B
6B
13B
16B
20B
24B
29B
34B
43B
45B
49B
50B
53B
54B
61B

B*4023
2B
6B
13B
16B
20B
24B
29B
34B
41B
45B
49B
50B
52B
53B
54B
61B

B*4101
2B
6B
13B
16B
20B
24B
29B
34B
42B
46B
49B
50B
52B
53B
54B
61B
62B

B*4103
2B
6B
13B
16B
20B
24B
29B
34B
42B
46B
49B
50B
52B
53B
54B
61B
62B

B*4105
2B
6B
13B
16B
20B
27B
29B
34B
42B
46B
49B
50B
52B
53B
54B
61B
62B

B*4502
2B
6B
13B
16B
20B
24B
29B
40B
42B
47B
49B
50B
52B
53B
54B
58B
59B
60B
61B

B*4409
2B
6B
13B
16B
20B
24B
29B
36B
42B
47B
50B
52B
53B
54B
60B
62B

B*4702
2B
6B
13B
16B
20B
24B
29B
36B
43B
45B
50B
52B
53B
54B

B*4703
2B
6B
13B
16B
20B
24B
29B
36B
43B
45B
50B
52B
53B
54B
57B

B*4501
2B
6B
13B
16B
20B
24B
29B
35B
42B
47B
49B
50B
52B
53B
54B
58B
59B
60B
61B

B*4504
2B
6B
13B
16B
20B
24B
29B
35B
42B
47B
49B
50B
52B
53B
54B
58B
59B
60B
61B

B*4503
2B
6B
13B
16B
20B
24B
29B
35B
42B
47B
49B
50B
52B
53B
54B
58B
59B
60B
61B

B*5001
2B
6B
13B
16B
20B
24B
29B
35B
43B
47B
49B
50B
52B
53B
54B
58B
59B
60B
61B

B*5002
2B
6B
13B
16B
20B
24B
29B
35B
43B
47B
49B
50B
52B
53B
54B
58B
59B
59B
60B

B*5004
2B
6B
13B
16B
20B
24B
29B
35B
43B
47B
49B
50B
52B
53B
54B
60B
61B
62B

B*1553
2B
6B
13B
16B
20B
24B
29B
38B
44B
47B
50B
52B
53B
54B
62B
64B

B*4031
2B
6B
13B
16B
20B
24B
28B
34B
43B
45B
49B
50B
52B
53B
54B

B*4015
2B
6B
13B
16B
20B
24B
28B
34B
41B
45B
49B
50B
52B
53B
54B
61B

B*4016
2B
6B
13B
16B
20B
24B
28B
34B
41B
45B
49B
50B
52B
53B
54B
61B

B*4032
2B
6B
13B
16B
20B
24B
28B
34B
41B
45B
49B
50B
52B
53B
54B

B*4102
2B
6B
13B
16B
20B
24B
28B
34B
42B
46B
49B
50B
52B
53B
54B
61B
62B

B*4104
2B
6B
13B
16B
20B
24B
28B
34B
42B
46B
49B
50B
52B
53B
54B
59B
62B

B*4415
2B
6B
13B
16B
20B
25B
29B
35B
42B
47B
49B
50B
52B
53B
54B
56B
57B
58B
59B

B*4030
2B
6B
13B
16B
20B
24B
33B
34B
43B
45B
49B
50B
52B
53B
54B
61B

B*4034
2B
6B
13B
16B
20B
24B
33B
34B
43B
45B
49B
50B
52B
53B
54B
61B

B*44021
2B
6B
13B
16B
21B
25B
29B
36B
42B
47B
50B
52B
53B
54B
56B
57B
60B
62B

B*4414
2B
6B
13B
16B
21B
25B
29B
36B
42B
47B
50B
52B
53B
54B
56B
57B
61B
62B

B*4411
2B
6B
13B
16B
21B
25B
29B
36B
42B
47B
50B
52B
53B
54B
57B
60B
62B

B*4412
2B
6B
13B
16B
21B
25B
29B
36B
42B
47B
50B
53B
54B
56B
57B
60B
62B

B*4424
2B
6B
13B
168
21B
25B
29B
36B
42B
47B
50B
52B
53B
54B
56B
57B
60B
62B

B*4416
2B
6B
13B
16B
21B
25B
29B
36B
42B
45B
50B
52B
53B
54B
56B
57B
60B
62B

B*4421
2B
6B
13B
16B
21B
25B
29B
36B
42B
45B
50B
52B
53B
54B
56B
57B
60B
62B

B*44031
2B
6B
13B
16B
21B
25B
29B
36B
43B
47B
50B
52B
53B
54B
56B
57B
60B
62B

B*44032
2B
6B
13B
16B
21B
25B
29B
36B
43B
47B
50B
52B
53B
54B
56B
57B
58B
60B
62B

B*4407
2B
6B
13B
16B
21B
25B
29B
36B
43B
47B
50b
52B
53B
54B
54B
57B
58B
60B
62B

B*4413
2B
6B
13B
16B
21B
25B
29B
36B
43B
47B
50b
52B
53B
54B
56B
57B
60B
62B

B*4404
2B
6B
13B
16B
21B
25B
29B
36B
41B
46B
50B
52B
53B
54B
56B
57B
60B
62B

B*4410
2B
6B
13B
16B
21B
25B
29B
35B
43B
47B
50B
52B
53B
54B
56B
57B
59B
61B
62B

B*4902
2B
6B
13B
16B
21B
25B
29B
35B
43B
47B
49B
50B
52B
53B
54B
56B
57B
58B
59B

B*4417
2B
6B
13B
16B
21B
25B
29B
38B
42B
47B
50B
52B
53B
54B
56B
57B
62B

B*4420
2B
6B
13B
16B
21B
25B
30B
36B
42B
47B
50B
52B
53B
54B
56B
57B
58B
60B
62B

B*4418
2B
6B
13B
16B
21B
26B
29B
35B
42B
47B
49B
50B
52B
53B
54B
56B
57B
58B
59B

B*4901
2B
6B
13B
16B
21B
26B
29B
35B
43B
47B
49B
50B
52B
53B
54B
56B
57B
58B
59B

B*4701
2B
6B
13B
16B
22B
25B
29B
36B
43B
45B
50B
52B
53B
54B
57B

B*4007
2B
6B
13B
15B
20B
24B
29B
34B
43B
45B
49B
50B
52B
53B
54B
61B

B*44022
2B
6B
13B
19B
21B
25B
29B
36B
42B
47B
50B
52B
53B
54B
56B
57B
60B
62B

B*4408
2B
6B
11B
16B
21B
25B
29B
36B
42B
47B
50B
52B
53B
54B
56B
57B
60B
62B

B*1301
2B
6B
11B
16B
21B
25B
29B
35B
43B
45B
51B
52B
53B
54B
56B
57B
58B
59B
61B

B*1306
2B
6B
11B
16B
21B
25B
29B
35B
43B
46B
51B
52B
53B
54B
56B
57B
58B
59B
61B

B*1302
2B
6B
11B
16B
21B
25B
30B
35B
43B
45B
51B
52B
53B
54B
56B
57B
58B
59B
61B

B*1303
2B
6B
11B
16B
21B
25B
30B
35B
43B
47B
51B
52B
53B
54B
56B
57B
58B
59B
61B

B*1304
2B
6B
11B
16B
21B
25B
30B
38B
43B
47B
51B
52B
53B
54B
56B
57B
58B
59B
62B

B*0802
2B
5B
9B
15B
21B
25B
28B
34B
42B
46B
508
53B
56B
61B
62B

B*0806
2B
5B
9B
15B
21B
24B
28B
34B
41B
46B
50B
53B
61B

B*0803
2B
5B
9B
15B
21B
26B
28B
34B
42B
46B
50B
53B
54B
56B
57B
61B
62B

B*3525
2B
5B
9B
15B
20B
24B
29B
38B
43B
47B
50B
53B
54B
58B
59B
62B

B*0812
2B
5B
9B
15B
20B
24B
29B
34B
42B
46B
50B
53B
61B
62B

B*0801
2B
5B
9B
15B
20B
24B
28B
34B
42B
46B
50B
53B
61B
62B

B*0807
2B
5B
9B
15B
20B
24B
28B
34B
42B
46B
50B
53B
62B

B*0805
2B
5B
9B
15B
20B
24B
28B
34B
42B
46B
50B
53B
61B
62B

B*0810
2B
5B
9B
15B
20B
24B
28B
34B
42B
46B
50B
53B
61B
62B

B*0811
2B
5B
9B
15B
20B
24B
28B
34B
42B
48B
50B
53B
61B
62B

B*0813
2B
5B
9B
15B
20B
24B
28B
34B
43B
46B
50B
53B
61B
62B

B*0809
2B
5B
9B
15B
20B
24B
30B
34B
42B
46B
50B
53B
58B
61B
62B

B*1529
2B
5B
9B
15B
20B
24B
29B
38B
43B
47B
50B
53B
54B
62B
64B

B*0804
2B
5B
9B
16B
20B
24B
28B
34B
42B
46B
50B
53B
62B

B*4012
2B
5B
9B
16B
20B
24B
29B
34B
43B
45B
50B
52B
53B
54B
61B

B*1503
2B
5B
9B
16B
20B
24B
29B
38B
43B
47B
50B
52B
53B
54B
62B
64B

B*1564
2B
5B
9B
16B
20B
24B
29B
38B
43B
47B
50B
53B
54B
62B
64B

B*1561
2B
5B
9B
16B
20B
24B
29B
38B
43B
47B
50B
52B
53B
62B
64B

B*1562
2B
5B
9B
16B
20B
24B
29B
38B
43B
47B
50B
52B
53B
54B
58B
59B
62B
64B

B*1547
2B
5B
9B
16B
20B
24B
29B
38B
41B
45B
50B
52B
53B
54B
62B
64B

B*1549
2B
5B
9B
16B
20B
24B
29B
38B
41B
45B
50B
52B
536
54B
62B
64B

B*1554
2B
5B
9B
16B
20B
24B
29B
38B
44B
47B
50B
52B
53B
54B
62B
64B

B*3904
2B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
53B
61B
62B
63B

B*1509
2B
5B
9B
17B
20B
24B
29B
34B
43B
47B
50B
53B
54B
61B
62B
64B

B*1510
2B
5B
9B
17B
20B
24B
29B
34B
43B
47B
50B
53B
54B
62B
64B

B*1537
2B
5B
9B
17B
20B
24B
29B
34B
43B
47B
50B
53B
54B
62B
64B

B*1518
2B
5B
9B
17B
20B
24B
29B
38B
43B
47B
50B
53B
54B
62B
64B

B*1551
2B
5B
9B
17B
20B
24B
29B
38B
42B
47B
50B
53B
54B
62B
64B

B*1552
2B
5B
9B
17B
20B
24B
29B
38B
43B
45B
50B
53B
54B
62B
64B

B*1523
2B
5B
9B
17B
21B
26B
29B
38B
43B
47B
50B
53B
54B
56B
57B
62B
64B

B*8301
2B
5B
9B
14B
20B
24B
29B
36B
42B
47B
60B
62B

B*5606
2B
8B
12B
14B
20B
24B
30B
34B
43B
47B
51B
61B
62B

B*7801
2B
8B
12B
15B
20B
24B
30B
34B
43B
47B
51B
53B
61B
62B

B*78022
2B
8B
12B
15B
20B
24B
30B
34B
43B
47B
51B
53B
54B
61B
62B

B*5306
2B
8B
12B
15B
21B
26B
29B
38B
43B
47B
51B
53B
54B
56B
57B
58B
59B
62B

B*4406
2B
8B
12B
15B
21B
26B
29B
36B
42B
47B
51B
53B
54B
56B
57B
60B
62B

B*5104
2B
8B
12B
15B
21B
26B
29B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5106
2B
8B
12B
15B
21B
26B
29B
34B
43B
47B
51B
53B
54B
56B
57B
61B
62B

B*51131
2B
8B
12B
15B
21B
26B
30B
40B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*51132
2B
8B
12B
15B
21B
26B
30B
40B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5116
2B
8B
12B
15B
21B
26B
30B
34B
43B
45B
51B
53B
54B
56B
57B
58B
61B
62B

B*5110
2B
8B
12B
15B
21B
26B
30B
34B
43B
45B
51B
53B
54B
56B
57B
58B
61B

B*5121
2B
8B
12B
15B
21B
26B
30B
34B
43B
46B
51B
53B
54B
56B
57B
58B
61B
62B

B*51011
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*51021
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*51014
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5124
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*51013
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5109
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5103
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5123
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5119
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B
63B

B*5114
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5117
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5118
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5112
2B
8B
12B
15B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5108
2B
8B
12B
15B
21B
26B
30B
34B
42B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*5120
2B
8B
12B
15B
21B
26B
30B
34B
42B
47B
51B
53B
56B
57B
57B
61B
62B

B*5107
2B
8B
12B
16B
21B
26B
30B
34B
43B
47B
51B
53B
54B
56B
57B
58B
61B
62B

B*52012
2B
8B
12B
16B
21B
26B
30B
34B
43B
47B
51B
52B
53B
54B
56B
57B
58B
61B
62B

B*5203
2B
8B
12B
16B
21B
26B
30B
34B
43B
47B
51B
52B
53B
54B
56B
57B
58B
61B
62B

B*4903
2B
8B
12B
16B
21B
26B
29B
35B
43B
47B
49B
51B
52B
54B
56B
57B
58B
58B
60B

B*1804
2B
8B
12B
16B
20B
24B
29B
38B
43B
46B
51B
53B
54B
62B
64B

B*5122
2B
8B
12B
17B
21B
26B
30B
34B
43B
47B
51B
53B
56B
54B
58B
61B
62B

B*7803
2B
8B
12B
17B
20B
24B
30B
34B
43B
47B
51B
53B
61B
62B

B*5605
2B
8B
9B
14B
20B
24B
30B
34B
43B
47B
50B
61B
62B

B*5202
2B
8B
11B
16B
21B
26B
30B
34B
43B
47B
52B
53B
54B
56B
57B
58B
61B
62B

B*4020
1B
6B
13B
16B
20B
24B
29B
38B
43B
45B
49B
50B
52B
53B
54B

B*4004
1B
6B
13B
16B
20B
24B
29B
34B
43B
45B
49B
50B
52B
53B
54B
61B

B*4011
1B
6B
13B
16B
20B
24B
29B
34B
43B
45B
49B
50B
52B
53B
54B
61B

B*4026
1B
6B
13B
16B
20B
24B
29B
34B
43B
47B
49B
50B
52B
53B
54B
61B
62B

B*4028
1B
6B
13B
16B
20B
24B
29B
34B
43B
47B
49B
50B
52B
53B
54B
61B
62B

B*4003
1B
6B
13B
16B
20B
24B
28B
38B
43B
45B
49B
50B
52B
53B
54B

B*4005
1B
6B
13B
16B
20B
24B
28B
34B
43B
45B
49B
50B
52B
53B
54B
61B

B*4018
1B
6B
13B
16B
20B
24B
28B
34B
43B
45B
49B
50B
52B
53B
54B

B*4002
1B
6B
13B
16B
20B
24B
28B
34B
43B
45B
49B
50B
52B
53B
54B
61B

B*4009
1B
6B
13B
16B
20B
24B
28B
34B
43B
45B
49B
50B
52B
53B
54B
60B

B*4024
1B
6B
13B
16B
20B
24B
28B
34B
43B
45B
49B
50B
52B
53B
54B
59B

B*4029
1B
6B
13B
16B
20B
24B
28B
34B
43B
45B
49B
50B
53B
54B
61B

B*4027
1B
6B
13B
16B
20B
24B
28B
39B
43B
45B
49B
50B
52B
53B
54B
61B

B*4006
1B
6B
13B
16B
20B
24B
30B
34B
43B
45B
49B
50B
52B
53B
54B
61B

B*4019
1B
6B
13B
16B
21B
26B
28B
34B
43B
45B
49B
50B
52B
53B
54B
56B
57B
61B

B*4008
1B
6B
13B
15B
20B
24B
28B
34B
43B
45B
49B
50B
53B
54B
61B

B*4013
1B
6B
13B
15B
21B
26B
26B
34B
43B
45B
49B
50B
52B
53B
54B
56B
57B
61B

B*7301
1B
6B
9B
17B
23B
24B
30B
40B
43B
45B
49B
55B
60B
61B

B*2701
1B
6B
9B
17B
21B
25B
32B
36B
43B
45B
50B
52B
54B
56B
57B
58B
64B

B*2702
1B
6B
9B
17B
21B
26B
32B
36B
43B
45B
50B
52B
56B
57B
58B
64B

B*2707
1B
6B
9B
17B
22B
25B
28B
34B
43B
45B
50B
52B
57B
61B
64B

B*27052
1B
6B
9B
17B
22B
25B
32B
36B
43B
45B
50B
52B
57B
58B
64B

B*27054
1B
6B
9B
17B
22B
25B
32B
36B
43B
45B
50B
52B
57B
58B
64B

B*2713
1B
6B
9B
17B
22B
25B
32B
36B
43B
45B
50B
52B
57B
58B
64B

B*2716
1B
6B
9B
17B
22B
25B
32B
36B
43B
45B
50B
53B
52B
57B
58B
64B

B*2710
1B
6B
9B
17B
22B
25B
32B
36B
43B
45B
50B
52B
57B
58B
64B

B*2703
1B
6B
9B
17B
22B
25B
32B
36B
43B
45B
50B
52B
57B
58B
64B

B*2717
1B
6B
9B
17B
22B
25B
32B
36B
43B
45B
50B
52B
57B
58B
64B

B*2709
1B
6B
9B
17B
22B
25B
32B
37B
43B
45B
50B
52B
57B
58B
64B

B*2714
1B
6B
9B
17B
22B
25B
30B
36B
43B
45B
50B
52B
57B
58B
59B
64B

B*2719
1B
6B
9B
17B
22B
25B
29B
36B
43B
45B
50B
52B
57B
64B

B*2704
1B
6B
9B
17B
20B
25B
32B
36B
43B
45B
50B
52B
57B
58B
64B

B*2715
1B
6B
9B
17B
20B
25B
32B
36B
43B
46B
50B
52B
57B
58B
64B

B*2706
1B
6B
9B
17B
20B
25B
32B
34B
43B
45B
50B
52B
57B
58B
60B
64B

B*2722
1B
6B
9B
17B
20B
25B
32B
34B
43B
45B
50B
52B
57B
58B
60B
64B

B*2720
1B
6B
9B
17B
20B
25B
32B
34B
43B
45B
50B
52B
57B
61B
64B

B*2711
1B
6B
9B
17B
20B
25B
28B
34B
43B
45B
50B
52B
57B
61B
64B

B*2721
1B
6B
9B
17B
20B
25B
29B
34B
43B
45B
50B
52B
57B
60B
64B

B*2708
1B
6B
9B
17B
20B
24B
32B
36B
43B
45B
50B
52B
58B
64B

B*2712
1B
6B
9B
17B
20B
24B
32B
36B
43B
45B
50B
52B
53B
58B
64B

B*2718
1B
6B
9B
16B
20B
24B
32B
36B
43B
45B
50B
52B
53B
54B
58B
64B

B*2723
1B
6B
9B
15B
20B
25B
32B
36B
43B
45B
50B
53B
54B
57B
58B
64B

B*3803
1B
5B
9B
16B
20B
25B
29B
40B
43B
46B
50B
53B
52B
56B
57B
61B
62B
63B

B*4802
1B
5B
9B
16B
20B
24B
29B
38B
43B
47B
52B
53B
54B
58B
59B
62B

B*4801
1B
5B
9B
16B
20B
24B
28B
34B
43B
45B
52B
53B
54B
61B

B*4804
1B
5B
9B
16B
20B
24B
28B
34B
43B
45B
52B
53B
54B
61B

B*4807
1B
5B
9B
16B
20B
24B
28B
40B
43B
45B
52B
53B
54B
61B

B*4803
1B
5B
9B
16B
20B
24B
29B
34B
43B
45B
52B
53B
54B
61B

B*39021
1B
5B
9B
16B
20B
24B
29B
40B
43B
46B
50B
53B
52B
61B
62B
63B

B*39022
1B
5B
9B
16B
20B
24B
29B
40B
43B
46B
50B
52B
53B
61B
62B
63B

B*3913
1B
5B
9B
16B
20B
24B
29B
40B
43B
46B
50B
52B
53B
54B
61B
62B
63B

B*3923
1B
5B
9B
16B
20B
24B
29B
40B
43B
46B
50B
52B
53B
616
61B
63B

B*3908
1B
5B
9B
16B
20B
24B
29B
40B
41B
46B
50B
52B
53B
54B
61B
62B
63B

B*3914
1B
5B
9B
17B
20B
24B
28B
34B
43B
46B
50B
53B
61B
62B
63B

B*3903
1B
5B
9B
17B
20B
24B
28B
40B
43B
46B
50B
53B
61B
62B
63B

B*3924
1B
5B
9B
17B
20B
24B
28B
40B
43B
46B
50B
53B
61B
62B
63B

B*39011
1B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
53B
61B
62B
63B

B*39013
1B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
53B
61B
62B
63B

B*3915
1B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
53B
62B
63B

B*3909
1B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
53B
61B
62B
63B

B*39014
1B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
53B
54B
61B
62B
63B

B*3905
1B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
53B
61B
62B
63B

B*3922
1B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
52B
53B
61B
62B
63B

B*3918
1B
5B
9B
17B
20B
24B
29B
40B
44B
46B
50B
53B
61B
62B
63B

B*3911
1B
5B
9B
17B
20B
24B
29B
40B
41B
46B
50B
53B
54B
61B
62B
63B

B*39061
1B
5B
9B
17B
20B
24B
30B
40B
43B
46B
50B
53B
61B
62B
63B

B*39062
1B
5B
9B
17B
20B
24B
30B
40B
43B
46B
50B
53B
58B
61B
62B
63B

B*4201
1B
5B
9B
14B
20B
24B
28B
34B
42B
46B
61B
62B

B*4202
1B
5B
9B
14B
20B
24B
28B
34B
42B
46B
49B
61B
62B

B*0719
1B
5B
9B
14B
20B
24B
28B
34B
42B
46B
64B

B*0704
1B
5B
9B
14B
20B
24B
28B
34B
42B
45B

B*0725
1B
5B
9B
14B
20B
24B
28B
34B
42B
45B

B*8101
1B
5B
9B
14B
20B
24B
28B
34B
43B
45B
61B

B*07021
1B
5B
9B
14B
20B
24B
28B
34B
41B
45B

B*07022
1B
5B
9B
14B
20B
24B
26B
34B
41B
45B

B*0723
1B
5B
9B
14B
20B
24B
28B
34B
41B
45B

B*0705
1B
5B
9B
14B
20B
24B
28B
34B
41B
45B
61B

B*0703
1B
5B
9B
14B
20B
24B
28B
34B
41B
45B
53B

B*07023
1B
5B
9B
14B
20B
24B
28B
34B
41B
45B
50B

B*0715
1B
5B
9B
14B
20B
24B
28B
34B
41B
45B
55B

B*0716
1B
5B
9B
14B
20B
24B
28B
34B
41B
45B
53B
54B

B*0721
1B
5B
9B
14B
20B
24B
28B
34B
41B
45B

B*0722
1B
5B
9B
14B
20B
24B
28B
34B
41B
45B

B*0720
1B
5B
9B
14B
20B
24B
28B
34B
41B
47B

B*0724
1B
5B
9B
14B
20B
24B
28B
34B
41B
47B

B*0709
1B
5B
9B
14B
20B
24B
28B
38B
41B
45B

B*0717
1B
5B
9B
14B
20B
24B
28B
38B
41B
45B
60B

B*3917
1B
5B
9B
14B
20B
24B
29B
35B
43B
46B
50B
53B
61B
60B
62B
63B

B*3910
1B
5B
9B
14B
20B
24B
29B
40B
43B
46B
50B
53B
61B
62B
63B

B*67012
1B
5B
9B
14B
20B
24B
29B
40B
43B
46B
50B
61B
62B
63B

B*3916
1B
5B
9B
14B
20B
24B
29B
40B
43B
46B
50B
53B
61B
62B
63B

B*67011
1B
5B
9B
14B
20B
24B
29B
40B
43B
46B
50B
61B
62B
63B

B*0706
1B
5B
9B
14B
20B
24B
29B
34B
41B
45B
61B

B*0707
1B
5B
9B
14B
20B
24B
29B
34B
41B
45B

B*0712
1B
5B
9B
14B
20B
24B
29B
34B
41B
45B
58B
59B

B*0714
1B
5B
9B
14B
20B
24B
29B
34B
41B
45B
60B

B*0718
1B
5B
9B
14B
20B
24B
29B
34B
41B
45B
58B

B*5510
1B
5B
9B
14B
20B
24B
30B
35B
43B
46B
50B
51B
62B

B*3920
1B
5B
9B
14B
21B
24B
29B
40B
43B
46B
50B
53B
54B
61B
62B
63B

B*0711
1B
5B
9B
14B
21B
24B
28B
38B
41B
45B

B*3801
1B
5B
9B
17B
21B
26B
29B
40B
43B
46B
50B
53B
54B
56B
57B
61B
62B
63B

B*38021
1B
5B
9B
17B
21B
25B
29B
40B
43B
46B
50B
53B
54B
56B
57B
61B
62B
63B

B*38022
1B
5B
9B
17B
21B
25B
29B
40B
43B
46B
50B
53B
54B
56B
57B
61B
62B
63B

B*3804
1B
5B
9B
17B
21B
25B
29B
40B
43B
46B
50B
52B
53B
54B
56B
57B
61B
62B
63B

B*4806
1B
5B
9B
15B
20B
24B
28B
34B
43B
45B
53B
54B
61B

B*0708
1B
5B
9B
15B
20B
24B
28B
34B
41B
45B
53B

B*0710
1B
5B
9B
17B
20B
24B
28B
34B
41B
45B

B*1401
1B
5B
9B
17B
20B
24B
31B
40B
43B
46B
50B
53B
58B
60B
61B
62B
64B

B*6702
1B
5B
10B
14B
20B
24B
29B
40B
43B
46B
50B
52B
55B
61B
62B
63B

B*0713
1B
5B
10B
14B
20B
24B
28B
34B
41B
45B
52B
55B

B*3919
1B
5B
12B
17B
20B
24B
29B
40B
43B
46B
50B
51B
53B
61B
62B
63B

B*3806
1B
5B
12B
15B
21B
26B
29B
40B
43B
46B
50B
51B
53B
54B
56B
57B
61B
62B
63B

B*3807
1B
5B
12B
15B
21B
26B
29B
40B
43B
46B
50B
51B
53B
54B
56B
57B
61B
62B
63B

B*1807
1B
5B
12B
15B
20B
24B
29B
38B
43B
46B
51B
53B
54B
62B
64B

B*3701
1B
5B
12B
16B
22B
25B
29B
40B
42B
46B
49B
51B
52B
54B
57B
60B
61B
62B

B*3704
1B
5B
12B
16B
22B
25B
29B
40B
42B
46B
49B
51B
52B
54B
57B
60B
61B
62B

B*3702
1B
5B
12B
16B
22B
25B
32B
36B
43B
45B
49B
51B
52B
54B
57B

B*3705
1B
5B
12B
16B
22B
24B
29B
40B
42B
46B
49B
51B
52B
54B
60B
61B
62B

B*1802
1B
5B
12B
16B
20B
24B
32B
38B
43B
46B
51B
53B
54B
58B
62B
64B

B*1801
1B
5B
12B
16B
20B
24B
29B
38B
43B
46B
51B
53B
54B
62B
64B

B*1803
1B
5B
12B
16B
20B
24B
29B
38B
43B
46B
51B
53B
62B
64B

B*1811
1B
5B
12B
16B
20B
24B
29B
38B
43B
46B
51B
53B
54B
62B
64B

B*1805
1B
5B
12B
16B
20B
24B
29B
38B
43B
46B
51B
53B
54B
62B
64B

B*1806
1B
5B
12B
16B
20B
24B
29B
38B
43B
46B
51B
53B
54B
55B
62B
64B

B*1808
1B
5B
12B
16B
20B
24B
29B
38B
43B
46B
51B
53B
54B
62B
64B

B*1812
1B
5B
12B
16B
20B
24B
29B
38B
43B
46B
51B
52B
54B
62B
64B

B*1810
1B
5B
12B
16B
20B
24B
29B
38B
43B
45B
51B
53B
54B
62B
64B

B*1813
1B
5B
12B
16B
20B
24B
29B
38B
41B
46B
51B
53B
54B
62B
64B

B*1809
1B
5B
12B
16B
21B
25B
29B
38B
43B
46B
51B
53B
54B
56B
57B
62B
64B

B*4805
1B
8B
9B
16B
20B
24B
28B
34B
41B
45B
52B
53B
54B
61B

B*5402
1B
7B
10B
14B
20B
24B
30B
35B
43B
46B
49B
50B
61B
62B

B*3907
*
*
9B
17B
20B
24B
29B
38B
43B
46B
53B
54B
62B

B*27053
*
*
9B
17B
22B
25B
32B
36B
43B
45B
50B
52B
57B
58B

B*4405
*
*
*
16B
21B
25B
29B
34B
42B
47B
52B
53B
54B
56B
57B
60B
62B

B*3805
3B
5B
9B
17B
21B
26B
29B
40B
43B
46B
50B
53B
54B
56B
57B
61B
62B
63B

B*3912
3B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
61B
62B
63B

B*1402
3B
5B
9B
17B
20B
24B
31B
40B
43B
46B
50B
53B
58B
60B
61B
62B
64B

B*1404
3B
5B
9B
17B
20B
24B
31B
40B
43B
46B
50B
58B
60B
61B
62B
64B

B*1403
3B
5B
9B
17B
20B
24B
31B
40B
41B
46B
50B
53B
58B
60B
61B
62B
64B

B*1405
3B
5B
9B
17B
20B
24B
28B
40B
43B
46B
50B
53B
60B
61B
62B
64B

B*14061
3B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
53B
60B
61B
62B
64B

B*14062
3B
5B
9B
17B
20B
24B
29B
40B
43B
46B
50B
53B
58B
60B
61B
62B
64B

B*4422
3B
6B
13B
16B
21B
25B
29B
36B
42B
47B
50B
52B
53B
54B
56B
57B
60B
62B

B*8201
4B
5B
9B
14B
20B
24B
29B
35B
42B
47B
50B
61B
62B

B*8202
4B
5B
9B
14B
20B
24B
29B
35B
42B
47B
50B
61B
62B

patchwork region
satellite region

B*35011

1184
1201
1232
1242
1267
1272
1285

B*3524

1184
1201
1232
1242
1267
1272
1285
1293

B*3529

1184
1201
1232
1242
1267
1272
1285

B*3511

1184
1201
1232
1242
1267
1272

B*3514

1184
1201
1232
1242
1267
1272

B*3521

1184
1201
1232
1242
1267
1272
1293

B*35012

1184
1201
1232
1242
1267
1272
1285
1288

B*3505

1184
1201
1242
1267
1272
1285

B*3507

1172
1184
1201
1232
1242
1267
1272
1285

B*3510

1184
1201
1232
1242
1267
1272
1285

B*3523

1184
1201
1232
1239
1242
1267
1272
1285

B*3515

1184
1201
1232
1242
1267
1272
1285

B*3508

1184
1201
1232
1242
1267
1272
1285

B*1522

1184
1201
1267
1297

B*1559

1184
1201
1267
1297

B*35091

1184
1201
1232
1242
1272
1285

B*35092

1184
1201
1232
1242
1285

B*3504

1184
1201
1232
1242
1267
1272
1285

B*3502

1184
1201
1232
1242
1244
1267
1272
1285

B*3512

1184
1201
1232
1267
1272
1285

B*3518

1184
1201
1232
1242
1285

B*3503

1184
1201
1232
1242
1267
1272
1285

B*3506

1184
1201
1232
1242
1267
1272
1285

B*3513

1184
53B
1201
1232
1242
1267
1272
1285

B*3516

1184
53B
1201
1232
1242
1267
1272
1285

B*3517

1184
1201
1232
1242
1267
1272
1285

B*3530

1184
1201
1232
1267
1272
1285

B*3522

1184
1201
1267
1272
1285

B*3531

1184
1201
1285

B*3532

1184
1201
1242
1267
1272
1285

B*3535

1184
1201
1232
1242
1267
1272
1285

B*3534

1184
1201
1232
1242
1267
1272
1285

B*3533

1184
1201
1232
1242
1267
1272
1285

B*3536

1184
1201
1232
1242
1267
1272
1285

B*3537

1184
1201
1233
1242
1267
1272
1285

B*78021

1184
1201
1233
1263
1267
1272
1293

B*7804

1184
1201
1233
1263
1267
1272
1285

B*5305

1184
1201
1232
1242
1267
1272
1285

B*3527

1184
1201
1232
1242
1267
1272
1285

B*5304

1184
1201
1232
1242
1267
1272
1285

B*5307

1184
1201
1234
1267
1272
1285

B*5301

1184
1201
1232
1242
1267
1272
1285

B*5302

1184
1201
1232
1242
1267
1272
1285
1293

B*51012

1184
1201
1233
1263
1267
1272
1293

B*51022

1184
1201
1233
1263
1267
1272
1293

B*5105

1184
1201
1233
1263
1267
1272
1285
1293

B*5115

1184
1201
1233
1267
1272
1285

B*5303

1184
1201
1232
1242
1267
1272
1285

B*5801

1184
1191
1197
1199
1204
1232
1242
1267
1272
1285

B*5804

1184
1192
1197
1199
1204
1232
1242
1267
1272
1285

B*5805

1184
1191
1197
1199
1204
1232
1242
1267
1272
1286

B*5802

1184
1191
1197
1199
1204
1242
1267
1272
1285

B*5806

1184
1191
1197
1199
1204
1242
1267
1272

B*3520

1184
1232
1242
1267
1272
1285

B*3528

1184
1201
1232
1242
1267
1272
1285

B*7805

1184
1201
1233
1263
1267
1272
1293

B*52011

1184
1201
1233
1263
1267
1272
1293

B*52013

1184
1201
1233
1263
1267
1272
1293

B*3526

1184
1189
1201
1232
1242
1267
1272
1285

B*5504

1285

B*5501

1233
1267
1272

B*5502

1233
1267
1272
1285

B*5503

1233
1267
1272

B*5505

1187
1233
1267
1272

B*5601

1233
1267
1272
1285

B*5509

1233
1267
1272

B*5603

1267

B*5508

1285

B*5602

1267
1272
1285

B*5604

1267
1272
1285

B*5607

1233
1267
1272
1285

B*5901

1201
1233
1267
1272
1285

B*4601

1181
1184
1202
1267

B*4602

1181
1184
1202
1209
1267

B*15111

1181
1184
1201
1267
1297

B*15112

1181
184
1182
1201
1267
1297

B*5701

1181
184
1191
1197
1199
1204
1232
1267
1285

B*5704

1181
184
1191
1197
1199
1204
1232
1267
1285

B*5702

1181
184
1191
1197
1199
1204
1232
1267
1285

B*57031

1181
184
1191
1197
1199
1204
1232
1267
1285

B*57032

1181
184
1191
1197
1199
1204
1232
1267
1271
1285

B*5705

1181
184
1191
1197
1199
1204
1232
1267
1285

B*1516

1181
184
1199
1204
1233
1267
1297

B*1517

1181
1184
1199
1204
1259
1267
1297

B*5706

1181
1184
1191
1197
1199
1204
1232
1267
1285

B*5707

1181
1184
1191
1197
1199
1204
1232
1267
1285
1292

B*1508

1181
1184
1201
1267
1297

B*1556

1181
1184
1201
1267
1297

B*1521

1181
1184
1201
1232
1267
1297

B*1544

1181
1184
1201
1232
1267
1297

B*1513

1181
1184
1201
1232
1267
1297

B*1524

1181
1184
1201
1267
1297

B*1536

1181
1184
1201
1232
1267
1297

B*1557

1181
1184
1201
1267
1297

B*1504

1181
1184
1201
1233
1267
1297

B*1535

1181
1184
1201
1267
1297

B*1542

1181
1184
1201
1233
1267
1297

B*1530

1181
1184
1201
1267
1297

B*1563

1181
1184
1201
1267
1297

B*1548

1181
1184
1201
1267
1285
1297

B*4021

1181
1184
1201
1285
1292

B*1527

1181
1164
1201
1239
1267
1297

B*1532

1181
1184
1201
1267
1297

B*1515

1131
1184
1201
1267
1297

B*1501101

1181
1184
1201
1267
1297

B*1512

1181
1184
1201
1267
1290
1297

B*1519

1181
1184
1201
1267
1290
1297

B*15012

1181
1184
1201
1263
1267
1297

B*15013

1181
1184
1201
1266
1267
1297

B*15014

1176
1181
1184
1201
1267
1297

B*1514

1181
1184
1201
1267
1292
1297

B*1528

1181
1184
1196
1201
1267
1297

B*1533

1181
1184
1201
1270
1297

B*1534

1181
1184
1201
1267
1297

B*1538

1181
1184
1201
1267
1293
1297

B*1560

1177
1181
1184
1201
1267
1297

B*1550

1181
1184
1201
1267
1297

B*1525

1181
1184
1201
1232
1267
1297

B*1539

1181
1184
1201
1267
1297

B*1502

1181
1184
1201
1232
1267
1297

B*1505

1181
1184
1201
1267
1285
1297

B*1531

1181
1184
1201
1267
1285
1297

B*1506

1181
1184
1201
1239
1267
1297

B*1520

1181
1184
1201
1232
1242
1267
1285
1297

B*1540

1181
1184
1201
1267
1297

B*1558

1181
1184
1201
1267
1297

B*1507

1181
1184
1201
1267
1297

B*1555

1181
1184
1201
1267
1285
1297

B*1545

1181
1184
1201
1267
1297

B*1543

1181
1184
1201
1267
1297

B*3519

1184
1201
1232
1242
1267
1272
1285

B*4010

1178
1184
1201
1285

B*1546

1178
1184
1201
1267
1297

B*5401

1176
1185
1233
1267
1272
1285

B*5507

1233
1267
1272
1285

B*40011

1178
1184
1201
1285

B*40012

1178
1184
1201
1285

B*4033

1178
1184
1201
1285
1292

B*4014

1178
1184
1201
1272
1285

B*4025

1178
1184
1201
1285
1292

B*4023

1178
1184
1201
1292

B*4101

1178
1184
1201
1233
1272
1285
1292

B*4103

1173
1178
1184
1201
1272
1285
1292

B*4105

1178
1184
1201
1233
1272
1285
1292

B*4502
62B

1178
1184
1201
1233
1242
1267
1272
1285
1292

B*4409

1178
1184
1201
1232
1267
1272
1285
1292

B*4702

1178
1184
1201
1239
1267
1285

B*4703

1178
1184
1201
1239
1267
1285

B*4501
62B

1178
1184
1201
1233
1242
1267
1272
1285
1292

B*4504
62B

1178
1184
1201
1233
1242
1267
1272
1285

B*4503
62B

1178
1184
1201
1233
1242
1262
1267
1272
1285
1292

B*5001
62B

1178
1184
1201
1233
1242
1267
1272

B*5002
61B
62B

1178
1184
1201
1233
1242
1267
1272
1292

B*5004

1178
1184
1201
1233
1242
1267
1272

B*1553

1178
1184
1201
1267
1297

B*4031

1178
1184
1201
1285
1292

B*4015

1178
1184
1201
1293

B*4016

1178
1184
1201

B*4032

1178
1184
1201
1292

B*4102

1178
1184
1201
1272
1285
1292

B*4104

1178
1184
1201
1242
1272
1285
1292

B*4415
60B
61B
62B
1178
1184
1201
1233
1242
1267
1272
1285
1292

B*4030

1178
1184
1201
1232
1285
1292

B*4034

1178
1184
1201
1232
1264
1285
1292

B*44021

1178
1184
1201
1232
1267
1272
1285
1292

B*4414

1178
1184
1201
1232
1267
1272
1285
1292

B*4411

1178
1184
1201
1227
1232
1267
1272
1285
1292

B*4412

1178
1184
1201
1232
1267
1272
1285
1292

B*4424

1178
1185
1201
1232
1267
1272
1285
1292

B*4416

1178
1184
1201
1232
1267
1272
1285

B*4421

1178
1184
1201
1232
1267
1272
1285
1292

B*44031

1178
1184
1201
1232
1267
1272
1285
1292

B*44032

1178
1184
1201
1232
1267
1272
1285
1292

B*4407

1184
1201
1232
1267
1272
1285
1292

B*4413

1178
1184
1190
1201
1232
1267
1272
1285
1292

B*4404

1176
1184
1201
1232
1267
1272
1285
1292

B*4410

1178
1184
1201
1232
1239
1242
1267
1272
1285
1292

B*4902
60B
61B
62B
1178
1184
1201
1233
1242
1267
1272

B*4417

1178
1184
1201
1232
1267
1272
1285
1292

B*4420

1178
1184
1201
1233
1267
1272
1285
1292

B*4418
60B
61B
62B
1178
1184
1201
1233
1242
1267
1272
1285
1292

B*4901
60B
61B
62B
1178
1184
1201
1233
1242
1267
1272
1285

B*4701

1178
1184
1201
1239
1267
1285

B*4007

1178
1184
1201
1285

B*44022

1178
1184
1201
1232
1267
1272
1285
1292

B*4408

1181
1184
1201
1232
1267
1272
1285
1292

B*1301
62B
64B

1178
1184
1201
1232
1267
1272
1285
1297

B*1306
62B
64B

1178
1184
1201
1232
1267
1272
1285
1297

B*1302
62B
64B

1178
1184
1201
1233
1267
1272
1285
1297

B*1303
62B
64B

1178
1184
1201
1233
1267
1272
1285
1297

B*1304
64B

1178
1184
1201
1233
1267
1285
1297

B*0802

1171
1201
1272
1285
1296

B*0806

1171
1201
1296

B*0803

1171
1201
1272
1285
1296

B*3525

1201
1232
1242
1267
1272
1285

B*0812

1171
1201
1272
1285
1296

B*0801

1171
1201
1272
1285
1296

B*0807

171
1201
1272
1285
1296

B*0805

171
1198
1201
1272
1285
1296

B*0810

171
1194
1201
1272
1285
1296

B*0811

171
1201
1272
1285
1296

B*0813

171
1201
1272
1285
1296

B*0809

171
1201
1272
1285
1296

B*1529

1201
1267
1297

B*0804

1171
1201
1272
1285
1296

B*4012

1184
1201
1285

B*1503

1201
1267
1297

B*1564

1201
1267
1297

B*1561

1201
1267
1297

B*1562

1201
1232
1242
1297

B*1547

1201
1267
1297

B*1549

1201
1206
1267
1297

B*1554

1201
1267
1297

B*3904

1189
1201
1267
1272
1285

B*1509

1201
1263
1267
1297

B*1510

1201
1267
1297

B*1537

1201
1267
1293
1297

B*1518

1201
1267
1297

B*1551

1201
1267
1285
1297

B*1552

1201
1267
1285
1297

B*1523

1201
1267
1297

B*8301

1232
1267
1272
1285
1292

B*5606

1184
1233
1263
1267
1272
1293

B*7801

1184
1201
1233
1263
1267
1272
1293

B*78022

1184
1201
1233
1263
1267
1272
1293

B*5306

1184
1201
1232
1242
1267
1272
1293

B*4406

1184
1201
1232
1267
1272
1285
1292

B*5104

1184
1201
1232
1263
1267
1272

B*5106

1184
1201
1263
1267
1272
1293

B*51131

1184
1201
1233
1267
1272
1293

B*51132

1184
1201
1233
1263
1267
1272
1293

B*5116

1184
1201
1233
1263
1267
1272
1293

B*5110

1184
1201
1233
1265

B*5121

1184
1201
1233
1263
1267
1272
1293

B*51011

1184
1201
1233
1263
1267
1272
1293

B*51021

1184
1201
1233
1263
1267
1272

B*51014

1184
1201
1233
1267
1272
1293

B*5124

1184
1201
1233
1272
1293

B*51013

1201
1233
1263
1267
1272
1293

B*5109

1184
1201
1233
1263
1267
1272
1285
1293

B*5103

1184
1201
1233
1263
1267
1272
1293

B*5123

1184
1201
1233
1263
1267
1272
1292

B*5119

1184
1201
1233
1263
1267
1272
1285
1293

B*5114

1184
1201
1233
1264
1263
1267
1272
1293

B*5117

1184
1201
1233
1243
1263
1267
1272
1293

B*5118

1184
1201
1233
1256
1263
1267
1272
1293

B*5112

1184
1201
1229
1233
1263
1267
1272
1293

B*5108

1184
1201
1233
1263
1267
1272
1285
1293

B*5120

1184
1201
1233
1263
1267
1272
1285
1293

B*5107

1184
1201
1233
1263
1267
1272
1293

B*52012

1184
1201
1233
1263
1267
1272
1293

B*5203

1184
1201
1233
1263
1267
1272
1285

B*4903
61B
62B

1184
1201
1233
1242
1267
1272

B*1804

1201
1267
1272
1285
1293
1297

B*5122

1184
1201
1233
1263
1267
1272
1293

B*7803

1184
1201
1233
1263
1267
1272
1293

B*5605

1233
1263
1267
1272
1293

B*5202

1181
1184
1201
1233
1263
1267
1272
1293

B*4020

1178
1184
1201
1285

B*4004

1178
1184
1201
1232
1285

B*4011

1178
1184
1201
1285

B*4026

1178
1184
1201
1263
1267
1292

B*4028

1178
1184
1201
1232
1263
1267
1272
1292
1293

B*4003

1178
1184
1201
1285

B*4005

1178
1184
1201

B*4018

1178
1184
1201
1285

B*4002

1178
1184
1201
1285

B*4009

1178
1184
1201
1285

B*4024

1178
1184
1201
1242
1285
1292

B*4029

1178
1184
1201
1193
1285
1292

B*4027

1178
1184
1201
1285
1292

B*4006

1178
1184
1201
1233
1285

B*4019

1178
1184
1201
1285

B*4008

1178
1184
1201
1285

B*4013

1178
1184
1201
1285

B*7301

1203
1233
1285
1293

B*2701

1171
1203
1259
1267
1285
1297

B*2702

1171
1203
1259
1267
1285
1297

B*2707

1171
1203
1285
1297

B*27052

1171
1203
1259
1267
1285
1297

B*27054

1171
1203
1259
1267
1285
1297

B*2713

1171
1203
1259
1267
1285
1297

B*2716

1171
1201
1259
1267
1285
1297

B*2710

1171
1203
1259
1267
1297

B*2703

1171
1203
1259
1267
1285
1297

B*2717

1171
1203
1259
1267
1285
1297

B*2709

1171
1203
1259
1267
1285
1297

B*2714

1171
1203
1233
1259
1267
1285
1297

B*2719

1171
1203
1232
1259
1267
1285
1297

B*2704

1171
1203
1259
1267
1297

B*2715

1171
1203
1259
1267
1297

B*2706

1171
1203
1267
1297

B*2722

1171
1203
1267
1297

B*2720

1171
1203
1297

B*2711

1171
1203
1265
1297

B*2721

1171
1203
1267
1297

B*2708

1171
1203
1259
1267
1285
1297

B*2712

1171
1201
1259
1267
1285
1297

B*2718

1171
1201
1259
1267
1297

B*2723

1171
1201
1259
1267
1285
1297

B*3803

1189
1201
1267
1272
1285

B*4802

1201
1232
1242
1267
1272
1285

B*4801

1201
1285

B*4804

1201
1285

B*4807

1201
1285

B*4803

1201
1285

B*39021

1189
1201
1267
1272
1285

B*39022

1201
1267
1272
1285

B*3913

1201
1267
1272
1285

B*3923

1201
1267
1272
1284
1285

B*3908

1189
1201
1267
1272
1285

B*3914

1189
1201
1267
1272
1285

B*3903

1189
1201
1267
1272
1285

B*3924

1189
1201
1236
1267
1272
1285

B*39011

1189
1201
1267
1272
1285

B*39013

1189
1201
1267
1272
1285

B*3915

1189
1201
1267
1272
1285

B*3909

1189
1201
1240
1267
1272
1285

B*39014

1186
1189
1201
1267
1272
1285

B*3905

1189
1201
1267
1272
1285

B*3922

1189
1201
1267
1272
1285

B*3918

1189
1201
1267

B*3911

1189
1201
1267
1272
1285

B*39061

1189
1201
1233
1267
1272
1285

B*39062

1189
1201
1233
1267
1272
1285

B*4201

1272
1285
1292

B*4202

1272
1285
1292

B*0719

B*0704

B*0725

1285

B*8101

1285

B*07021

B*07022

B*0723

1230

B*0705

B*0703

1201

B*07023

B*0715

1207

B*0716

1201

B*0721

1174

B*0722

1269

B*0720

1292

B*0724

B*0709

B*0717

B*3917

1201
1267
1272
1285

B*3910

1201
1267
1272
1285

B*67012

1267
1272
1285

B*3916

1201
1235
1267
1272
1285

B*67011

1189
1267
1272
1285

B*0706

B*0707

B*0712

1232
1242

B*0714

1232

B*0718

1232

B*5510

1233
1267
1272
1285

B*3920

1201
1267
1272
1285

B*0711

B*3801

1189
1201
1267
1272
1285

B*38021

1189
1201
1267
1272
1265

B*38022

1189
1201
1267
1272
1285

B*3804

1201
1267
1272
1285

B*4806

1201

B*0708

1201

B*0710

B*1401

1189
1201
1267
1272
1293
1297

B*6702

1185
1202
1207
1267
1272
1285

B*0713

1207

B*3919

1184
1201
1267
1272
1285

B*3806

1184
1201
1267
1272
1285

B*3807

1184
1188
1189
1201
1267
1272
1285

B*1807

1171
1201
1267
1272
1285
1293
1297

B*3701

1201
1234
1240
1267
1272
1285

B*3704

1201
1234
1240
1267
1272
1285
1293

B*3702

1201
1267
1285

B*3705

1201
1234
1240
1267
1272
1285

B*1802

1171
1201
1267
1272
1285
1293
1297

B*1801

1171
1201
1267
1272
1285
1293
1297

B*1803

1171
1201
1267
1272
1285
1293
1297

B*1811

1171
1201
1267
1272
1285
1297

B*1805

1171
1201
1265
1267
1272
1285
1293
1297

B*1806

1171
1201
1267
1272
1285
1293
1297

B*1808

1171
1201
1237
1267
1272
1285
1293
1297

B*1812

1171
1201
1267
1272
1285
1293
1297

B*1810

1171
1201
1267
1272
1285
1297

B*1813

1171
1201
1267
1272
1285
1293
1297

B*1809

1171
1201
1267
1272
1285
1293
1297

B*4805

1201

B*5402

1176
1185
1233
1267
1272
1285

B*3907

1189
1201
1267
1272
1285
65B

B*27053

1203
1259
1267
1285

B*4405

1184
1201
1232
1267
1272
1285
1292

B*3805

1189
1201
1267
1272
1285

B*3912

1171
1189
1201
1267
1272
1285

B*1402

1189
1201
1267
1272
1293
1297

B*1404

1189
1199
1201
1267
1272
1293
1297

B*1403

1189
1201
1267
1272
1293
1297

B*1405

1189
1201
1267
1272
1293
1297

B*14061

1189
1201
1267
1272
1293
1297

B*14062

1189
1201
1267
1272
1293
1297

B*4422

1178
1184
1201
1232
1267
1272
1285
1292

B*8201

1267
1272
1285
1292

B*8202

1267
1272
1285
1292

[0179]

32

TABLE 32

Correspondence of the patchworks and SEQ ID Nos for B

patchwork
SEQ ID NO:

1B
1080

2B
1081

3B
1082

4B
1083

5B
1084

6B
1085
1088

7B
1086

8B
1087

9B
1089
1094

10B
1090

11B
1091
1095

12B
1092
1096

13B
1093

14B
1097
1103
1106

15B
1098
1104

16B
1099

17B
1100
1105
1107
1108

18B
1101

19B
1102

20B
1109
1113
1115

21B
1110
1114

22B
1111

23B
1112

24B
1116
1120

25B
1117
1121
1122

26B
1118

27B
1119

28B
1123
1129
1133

29B
1124
1130
1134
1135
1136
1137
1138
1139
1140
1141

30B
1125
1131

31B
1126

32B
1127
1132

33B
1128

34B
1142
1149
1153
1156
1157

35B
1143
1150
1154

36B
1144
1151

37B
1145

38B
1146

39B
1147

40B
1148
1152
1155

41B
1158
1162

42B
1159

43B
1160
1163
1164

44B
1161

45B
1165

46B
1166

47B
1167
1169

48B
1168

49B
1170
1179

50B
1175
1180

51B
1183
1212
1218
1222

52B
1195
1213
1219
1223
1226

53B
1206
1215

54B
1209
1216
1220
1224

55B
1211
1217
1221
1225

56B
1227
1246

57B
1229
1247
1251
1253
1255
1256

58B
1239
1249
1252
1254

59B
1242
1250

60B
1259
1274
1277

61B
1261
1275
1278
1279
1280
1281
1282
1284

62B
1269
1276

63B
1288
1295

64B
1296
1299

[0180]

33

TABLE 33

Correspondence of Primers

SEQ ID NOS.
SEQ ID NOS.

Primers for DRB1
590, 591, 591
593

Primers for DPB1
448, 449
450-455

Primers for DQB1
504, 505
506

Primers for A
899, 900, 903-905
901, 902, 906, 907

Primers for B
1073, 1075-1077
1074, 1078, 1079

[0181] [References]

[0182] (1) Kobayashi, T. et al.: The significance of HLA-DRB1 matching in clinical renal transplantation, Transplantation, 54: 238, 1992

[0183] (2) Olerup, O. et al.: HLA-DR typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours: An alternative to serological DR typing in clinical practice including donor-recipient matching in cadaveric transplantation, Tissue Antigen, 39: 225, 1992

[0184] (3) Inoko, H. et al.: PCR-RFLP, Handbook of HLA typing techniques (edited by Hui, K. M. & Bidwell, J. L.), CRC press, Florida, U.S.A., 1993, p.9

[0185] (4) Erlich, H. et al.: HLA-DR, -DQ and -DP typing using PCR amplification and immobilized probes, European Journal of Immunogenetics, 18: 33, 1991

[0186] (5) Carrington, M. et al.: Typing of HLA-DQA1 and DQB1 using DNA single-strand conformation polymorphism, Hum. Immunol., 33: 208, 1992

[0187] Industrial Applicability

[0188] According to the present invention, there are provided a kit and method that are suitable for processing of a large number of specimens and enable a large number of high accuracy typing tests by one test for one specimen, and oligonucleotides and primers used therefor.

Kit and method for determining hla type

Information

Publication Number

Date Filed

Date Published

Inventors

CPC

US Classifications

International Classifications

Abstract

Description

Claims

PCT Information