Claims
- 1. An isolated polynucleotide which encodes a polypeptide, said polypeptide being comprised of an amino acid sequence, said amino acid sequence being at least 90% identical to one or more of the amino acid sequences selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12 and SEQ ID NO: 13.
- 2. An isolated polynucleotide of claim 1 wherein the polynucleotide encodes a polypeptide containing an amino acid sequence selected from the group consisting of SEQ ID NO: 2 and SEQ ID NO: 3.
- 3. An isolated polynucleotide of claim 1 wherein said polynucleotide is SEQ ID NO: 1.
- 4. An expression vector comprised of a transcription promoter; a polynucleotide encoding a polypeptide, said polypeptide being comprised of an amino acid sequence selected from the group consisting of SEQ ID NO: 2 SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12 and SEQ ID NO: 13, wherein the promoter and the polynucleotide encoding the polypeptide are operably linked.
- 5. A cell transfected or transformed with an expression vector, said expression vector being comprised of a transcription promoter; a polynucleotide encoding a polypeptide, said polypeptide being comprised of an amino acid sequence selected from the group consisting of SEQ ID NO: 2 SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12 and SEQ ID NO: 13, wherein the promoter and the polynucleotide encoding the polypeptide are operably linked.
- 6. An isolated polypeptide comprised of an amino acid sequence, said amino acid sequence being at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO: 2 SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12 and SEQ ID NO: 13.
- 7. An antibody which specifically binds to a polypeptide comprised of an amino acid sequence selected from the group consisting of SEQ ID NO: 2 SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12 and SEQ ID NO: 13.
- 8. An anti-idiotypic antibody that binds to an antibody of claim 7.
- 9. A method for treating cytokine-induced inflammation comprising administering an antagonist to a polypeptide, said polypeptide being comprised of an amino acid sequence selected from the group consisting of SEQ ID NO: 2 SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12 and SEQ ID NO: 13.
- 10. A method for inhibiting viral proliferation comprising a polypeptide comprised of SEQ ID NO: 3.
Parent Case Info
[0001] This claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional Application No. 60/208,137 filed May 31, 2000.
Provisional Applications (1)
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Number |
Date |
Country |
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60208137 |
May 2000 |
US |