Claims
- 1. A composition comprising an assayable amount of a compound of the formula ##STR12## wherein A.sub.1 and A.sub.2 are each independently hydrogen or --COOR.sub.4 wherein R.sub.4 is hydrogen; --CH.sub.2 O--C(O)C(CH.sub.3).sub.3 ; a C.sub.1 -C.sub.4 alkyl; an Ar--Y-- group wherein Ar is phenyl or naphtyl group unsubstituted or substituted with from one to three substituents selected from the group consisting of methylenedioxy, hydroxy, C.sub.1 -C.sub.4 alkoxy, fluoro and chloro and Y is a C.sub.0 -C.sub.4 alkyl; or diphenylmethyl; with the proviso that where A.sub.1 is hydrogen, A.sub.2 is --COOR.sub.4, and where A.sub.1 is --COOR.sub.4, A.sub.2 is hydrogen;
- B.sub.1 and B.sub.2 are each independently hydrogen; hydroxy; --OR.sub.5 wherein R.sub.5 is a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group; or, where B.sub.1 and B.sub.2 are attached to adjacent carbon atoms, B.sub.1 and B.sub.2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy;
- R.sub.2 is hydrogen, C.sub.1 -C.sub.8 alkyl, --CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 or an Ar--Y-- group;
- R.sub.3 is hydrogen, acetyl, --CH.sub.2 O--C(O)C(CH.sub.3).sub.3 or benzoyl; and
- n is an integer 0 or 1;
- in admixture or otherwise in association with an inert carrier.
- 2. A pharmaceutical composition comprising an effective immunosuppressive amount of a compound of the formula ##STR13## wherein B.sub.1 and B.sub.2 are each independently hydrogen; hydroxy; --OR.sub.5 wherein R.sub.5 is a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group wherein Ar is phenyl or naphtyl group unsubstituted or substituted with from one to three substituents selected from the group consisting of methylenedioxy, hydroxy, C.sub.1 -C.sub.4 alkoxy, fluoro and chloro and Y is a C.sub.0 -C.sub.4 alkyl; or, where B.sub.1 and B.sub.2 are attached to adjacent carbon atoms, B.sub.1 and B.sub.2 can be taken together with said adjacent carbons to form a benzene ring or methylenedioxy;
- R.sub.2 is hydrogen, C.sub.1 -C.sub.8 alkyl, CH.sub.2 OCH.sub.2 CH.sub.2 OCH.sub.3 or an Ar--Y-- group;
- R.sub.3 is hydrogen, acetyl, --CH.sub.2 O--C(O)C(CH.sub.3).sub.3 or benzoyl;
- R.sub.4 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group, --CH.sub.2 O--C(O)C(CH.sub.3).sub.3 or diphenylmethyl; and ##STR14## wherein R.sub.6 is hydrogen, a C.sub.1 -C.sub.4 alkyl or an Ar--Y-- group and R.sub.7 is --CF.sub.3, a C.sub.1 -C.sub.10 alkyl or an Ar--Y-- group.
- in admixture or otherwise in association with an inert carrier.
CROSS-REFERENCE TO RELATED APPLICATION
This is a division of application Ser. No. 08/149,572, filed Nov. 9, 1993 U.S. Pat. No. 5,430,145, which is a CIP of 08/075,981, filed Jun. 11, 1993, now abandoned; which is a CIP of 07/863,600, filed Apr. 3, 1992, now abandoned; which is a CIP of 07/735,496, filed Jul. 25, 1991 now abandoned; which is a CIP of 07/600,052, filed Oct. 18, 1990 now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5430145 |
Flynn et al. |
Jul 1995 |
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Divisions (1)
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Number |
Date |
Country |
Parent |
149572 |
Nov 1993 |
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Continuation in Parts (4)
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Number |
Date |
Country |
Parent |
75981 |
Jun 1993 |
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Parent |
863600 |
Apr 1992 |
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Parent |
735496 |
Jul 1991 |
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Parent |
600052 |
Oct 1990 |
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