METHOD AND APPARATUS FOR PROVIDING ION BARRIERS AT THE ENTRANCE AND EXIT ENDS OF A MASS SPECTROMETER

Abstract

There is provided a linear ion trap having an ion guide and a method of operating same. The ion guide has a first end and a second end. The method involves a) providing a first group of ions within the ion guide; b) providing a second group of ions within the ion guide, the second group of ions being opposite in polarity to the first group of ions; c) providing an RF drive voltage to the ion guide to radially confine the first group of ions and the second group of ions in the ion guide; d) providing a gas flow of an inert gas in a first axial direction away from the first end of the ion guide and toward a middle of the ion guide to repel both the first group of ions and the second group of ions from the first end of the ion guide; and, e) providing a trapping region barrier for repelling both the first group of ions and the second group of ions away from the second end of the ion guide. The gas flow in the first axial direction and the trapping region barrier together define a main trapping region for trapping both the first group of ions and the second group of ions.

Description

BRIEF DESCRIPTION OF THE DRAWINGS

The skilled person in the art will understand that the drawings, described below, are for illustration purposes only. The drawings are not intended to limit the scope of the applicant's teachings in anyway.

FIG. 1, in a schematic diagram, illustrates a linear ion trap mass spectrometer in which oppositely oriented gas flows are provided at each end of the linear ion trap in accordance with an embodiment of the invention.

FIG. 2, in a schematic diagram, illustrates a linear ion trap mass spectrometer in which oppositely oriented gas flows are provided at each end of the linear ion trap, which gas flows are channeled by confining sleeves in accordance with a further embodiment of the invention.

FIG. 3, in a schematic diagram, illustrates a linear ion trap mass spectrometer in which axial gas flows are provided at points part-way between the end and the mid-point of the linear ion trap mass spectrometer, which axial gas flows are channeled by confining sleeves in accordance with a further embodiment of the invention.

FIG. 4, in a schematic diagram, illustrates a linear ion trap mass spectrometer in which a barrier field is provided at one end of the rod set while axial gas flows are provided to a gas entry point part-way between the other end of the linear ion trap mass spectrometer and the midpoint of the linear ion trap mass spectrometer in accordance with a further embodiment of the invention.

FIG. 5, in a schematic diagram, illustrates a linear ion trap mass spectrometer in which a gas flow is provided at one end while a barrier field is provided at the other end of the linear ion trap mass spectrometer, and differential pumping is provided along the length of the linear ion trap mass spectrometer in accordance with a further embodiment of the invention.

FIG. 6, in a schematic diagram, illustrates a linear ion trap mass spectrometer in which oppositely oriented gas flows are provided at each end of the linear ion trap, and in which electrodes are provided to produce axial fields along the length of the mass spectrometer in accordance with a further embodiment of the invention.

FIG. 7, in a sectional view, illustrates the rods and electrodes of the linear ion trap mass spectrometer of FIG. 6.

FIGS. 8 a, 8b and 8c, in schematic diagrams, illustrate different stages of operation of the linear ion trap mass spectrometer of FIG. 6, together with different axial fields applied during these different stages of operation, in accordance with further aspects of this embodiment of the invention.

Claims

1. A method of operating a linear ion trap having an ion guide, the ion guide having a first end and a second end, the method comprising: a) providing a first group of ions within the ion guide;b) providing a second group of ions within the ion guide, the second group of ions being opposite in polarity to the first group of ions;c) providing an RF drive voltage to the ion guide to radially confine the first group of ions and the second group of ions in the ion guide;d) providing a gas flow of an inert gas in a first axial direction away from the first end of the ion guide and toward a middle of the ion guide to repel both the first group of ions and the second group of ions from the first end of the ion guide; and,e) providing a trapping region barrier for repelling both the first group of ions and the second group of ions away from the second end of the ion guide;wherein the gas flow in the first axial direction and the trapping region barrier together define a main trapping region for trapping both the first group of ions and the second group of ions.

2. The method of claim 1 wherein the trapping region barrier is provided by a second gas flow of a second inert gas, and step d) comprises providing the second gas flow in a second axial direction away from the second end of the ion guide and toward the middle of the ion guide to repel both the first group of ions and the second group of ions from the second end of the ion guide.

3. The method of claim 1 wherein the trapping region barrier comprises a second end auxiliary AC/RF voltage, and step d) comprises providing the second end auxiliary AC/RF voltage to the second end of the ion guide, the second end auxiliary AC/RF voltage being one of an AC voltage and an RF voltage.

4. The method as defined in claim 1 wherein step d) comprises providing the gas flow into the ion guide at the first end in the first axial direction.

5. The method as defined in claim 4 wherein step d) further comprises pumping the inert gas out of the ion guide at a pumping location spaced from the first end toward the middle of the ion guide to provide the gas flow in the first axial direction.

6. The method as defined in claim 1 wherein step d) comprises providing the gas flow into the ion guide at a gas inlet port wherein the gas inlet port is spaced from the first end toward the middle of the ion guide.

7. The method as defined in claim 6 further comprising providing a first end barrier for repelling at least one of the first group of ions and the second group of ions away from the first end of the ion guide; and,providing a gas counterflow in the second axial direction from the gas inlet port to the first end to define a first end auxiliary trapping region between the gas inlet port and the first end barrier.

8. The method as defined in claim 2 wherein the step of providing the second gas flow comprises providing the second gas flow into the ion guide at a second gas inlet port wherein the second gas inlet port is spaced from the second end toward the middle of the ion guide.

9. The method as defined in claim 8 further comprising providing a second end barrier for repelling at least one of the first group of ions and the second group of ions away from the second end of the ion guide; and,providing a second gas counterflow in the first axial direction from the gas inlet port to the second end to define a second end auxiliary trapping region between the gas inlet port and the second end barrier.

10. The method as defined in claim 9 wherein the second inert gas is the same gas as the inert gas.

11. The method as defined in claim 7 wherein the first end barrier is provided by a first end auxiliary voltage.

12. The method as defined in claim 11 wherein the first end auxiliary voltage is DC such that the first end auxiliary trapping region is operable to trap only ions of a single polarity.

13. The method as defined in claim 11 wherein the first end auxiliary voltage is AC/RF such that the first end barrier is operable to repel both the first group of ions and the second group of ions away from the first end of the ion guide, and the auxiliary trapping region is operable to concurrently trap ions of opposite polarity, the first end auxiliary AC/RF voltage being one of an AC voltage and an RF voltage.

14. The method as defined in claim 1 further comprising pumping the inert gas out of the ion guide at a first pumping location spaced from the first end toward the middle of the ion guide to provide the gas flow in the first axial direction; andpumping a residual amount of the inert gas out of the ion guide at a second pumping location spaced from the first pumping location toward the second end of the ion guide to reduce gas pressure within the main trapping region.

15. The method of claim 1 further comprising timing steps d) and e) to facilitate ion reactions between the first group of ions and the second group of ions to create a group of product ions; and, after steps d) and e),f) reducing the gas flow to facilitate transmission of the product ions via the first end of the ion guide.

16. The method of claim 1 further comprising timing steps d) and e) to facilitate ion reactions between the first group of ions and the second group of ions to create a group of product ions; and, after steps d) and e),f) providing an axial field to push the product ions past the gas flow for transmission via the first end of the ion guide.

17. The method of claim 16 wherein step f) further comprises reducing the gas flow to facilitate transmission of the product ions via the first end of the ion guide.

18. The method of claim 16 wherein step f) further comprises, during steps d) and e), i) orienting the axial field to separate the first group of ions and the second group of ions, and then ii) adjusting the axial field to facilitate ion reactions between the first group of ions and the second group of ions to create the group of product ions.

19. A linear ion trap comprising: an ion guide, the ion guide having a first end and a second end;an RF drive voltage power supply connected to the ion guide for providing an RF drive voltage to the ion guide to radially confine ions of both polarities within the ion guide;a first gas source for providing a first gas flow of an inert gas within the ion guide in a first axial direction away from the first end of the ion guide and toward a middle of the ion guide, the first gas flow having sufficient density and velocity to repel the ions of both polarities away from the first end and toward the second end;a trapping region barrier at the second end for repelling ions of both polarities away from the second end of the ion guide;wherein the gas flow in the first axial direction and the trapping region barrier together define a main trapping region for trapping ions of both polarities.

20. The linear ion trap of claim 19 further comprising a second gas source for providing a second gas flow of a second inert gas to provide the trapping region barrier, the second gas flow being in a second axial direction away from the second end of the ion guide and toward the middle of the ion guide and having sufficient density and velocity to repel ions of both polarities from the second end of the ion guide.

21. The linear ion trap of claim 19 wherein the trapping region barrier comprises a second end member and a second end auxiliary electrode for providing a second end auxiliary AC/RF voltage to the second end member to repel ions of both polarities from the second end of the ion guide.

22. The linear ion trap of claim 19 further comprising a pump for pumping the inert gas out of the ion guide at a pumping location spaced from the first end toward the middle of the ion guide to direct the gas flow in the first axial direction.

23. The linear ion trap of claim 19 wherein the first gas source comprises a gas inlet port for providing the gas flow into the ion guide, wherein the gas inlet port is spaced from the first end toward the middle of the ion guide.

24. The linear ion trap of claim 23 further comprising an auxiliary trapping region barrier at the first end for repelling ions away from the first end of the ion guide, wherein the auxiliary trapping region barrier comprises a first end member and a first end auxiliary electrode for providing a first end auxiliary AC/RF voltage to the first end member to repel ions from the first end of the ion guide, the first end auxiliary AC/RF voltage being one of an AC voltage and an RF voltage, and the gas inlet port being operable to provide a gas counterflow in a second axial direction from the gas inlet port to the first end to define a first end auxiliary trapping region between the gas inlet port and the first end barrier, the gas counterflow having sufficient density and velocity to repel ions of both polarities within the first end auxiliary trapping region away from the gas inlet port.

25. The linear ion trap of claim 20 wherein the second gas source comprises a second gas inlet port for providing the gas flow into the ion guide, wherein the second gas inlet port is spaced from the second end toward the middle of the ion guide.

26. The linear ion trap of claim 25 further comprising an auxiliary trapping region barrier at the second end for repelling ions away from the second end of the ion guide, wherein the auxiliary trapping region barrier comprises a second end member and a second end auxiliary electrode for providing a second end auxiliary AC/RF voltage to the second end member to repel ions from the second end of the ion guide, the second end auxiliary AC/RF voltage being one of an AC voltage and an RF voltage, the second gas inlet port is operable to provide a gas counterflow in a first axial direction from the gas inlet port to the second end to define a second end auxiliary trapping region between the second gas inlet port and the second end barrier, the gas counterflow having sufficient density and velocity to repel ions of both polarities within the second end auxiliary trapping region away from the gas inlet port.

27. The linear ion trap of claim 26 wherein the second inert gas is the same gas as the inert gas.

28. The linear ion trap of claim 26 wherein the first gas source is also the second gas source.

29. The linear ion trap of claim 19 further comprising a gas flow confinement means for surrounding the first gas flow from the first gas source and for channeling the first gas flow in the first axial direction.

30. The linear ion trap as defined in claim 19 wherein the first gas source comprises a gas control valve for controlling a flow rate of the first gas flow.

31. The linear ion trap as defined in claim 19 wherein the ion guide further comprises at least one electrode for providing an axial field along the ion guide; and,an auxiliary voltage power supply connected to the at least one electrode for providing an auxiliary voltage to the at least one electrode to provide the axial field, wherein the auxiliary voltage power supply is operable to vary the auxiliary voltage to vary the axial field.

32. The linear ion trap of claim 22 further comprising a second pump for pumping a residual amount of gas out of the ion guide at a second pumping location spaced from the first pumping location toward the second end of the ion guide to direct the gas flow in the first axial direction.