Claims
- 1. A method for controlled dissolution of a pharmaceutical product in a dissolution medium contained within a vessel, the method comprising steps of:
inducing a flow regime within the vessel characterized by high turbidity and minimum bulk movement of the dissolution medium; and simultaneously mechanically dispersing solid particles of the pharmaceutical product on a bottom portion of the vessel.
- 2. A method as claimed in claim 1, wherein the steps of inducing a flow regime within the vessel and simultaneously dispersing solid particles comprise steps of:
providing a brush body adapted to sweep a bottom portion of the vessel; repeatably biasing the brush body into sliding engagement with the bottom portion of the vessel and; causing controlled rotation of the brush body within the vessel.
- 3. A method as claimed in claim 2, wherein the step of causing controlled rotation of the brush body comprises driving the brush body to rotate at a speed of between 10 and 150 RPM.
- 4. A method as claimed in claim 2, wherein the step of causing controlled rotation of the brush body comprises driving the brush body to rotate in a selected direction.
- 5. A method as claimed in claim 4, wherein the selected direction is constant for at least a duration of a dissolution test.
- 6. A method as claimed in claim 4, wherein the selected direction is reversed at least once during a dissolution test.
- 7. A method as claimed in claim 2, wherein the brush body comprises an open structure adapted to admit a flow of dissolution medium through the brush body due to rotation of the brush body within the vessel.
- 8. A method as claimed in claim 2, wherein the brush body comprises a plurality of closely spaced filaments secured in a helical pattern about a support member.
- 9. A method as claimed in claim 2, wherein the step of repeatably biasing the brush body into sliding engagement with the bottom portion of the vessel comprises a step of providing means for applying a consistently repeatable bias force to the brush assembly.
- 10. A method as claimed in claim 9, wherein the means for applying a consistently repeatable bias force comprises any one or more of:
a spring; an elastomeric element; and a free-sliding coupling.
Priority Claims (1)
Number |
Date |
Country |
Kind |
2358575 |
Sep 2001 |
CA |
|
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a Continuation-in-part of U.S. patent application Ser. No. 10/100,134 filed Mar. 19, 2002. This application is also based on, and claims priority of, Canadian Patent Application No. 2,358,575 filed on Sep. 26, 2001.
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
10100134 |
Mar 2002 |
US |
Child |
10608474 |
Jun 2003 |
US |