The present application relates to chondral graft transfer, and more particularly to a method and system for the creation of patient-specific instrumentation for performing chondral graft transfer, for instance in an osteoarticular transfer procedure for the knee.
In pre-knee replacement treatment for arthritis, cartilage replacement is often used on some patients (e.g., younger active patients) as a stopgap measure to delay the need for a complete total knee arthroplasty (a.k.a, total knee replacement). There are numerous possible treatments involving replacement of the cartilage with autografts or with allografts.
One such autograft treatment is the osteoarticular transfer, referred to as OATS, designed to remove cartilage from one area and graft it onto another. One consideration in such treatment is the need to match both cartilage thickness and curvature between donor location and graft location, to ensure an optimal graft. Indeed, with improper graft shapes, there may result some difficulties in aligning the hyaline cartilage in thickness and/or curvature.
It is therefore an aim of the present disclosure to provide a novel method and system to create patient-specific instrumentation to perform chondral graft transfer.
Therefore, in accordance with a first embodiment of the present application, there is provided a method for creating at least one patient-specific instrument model for chondral graft removal, comprising: determining a graft geometry from a defect region in a bone/cartilage model of an articular region of a bone; identifying at least one donor location from the bone/cartilage model, using the graft geometry; and creating a model of at least one graft-removal patient-specific instrument using the at least one donor location, the graft geometry, and the bone/cartilage model, the graft-removal patient-specific instrument model comprising a bone/cartilage interface surface shaped as a function of the bone/cartilage model for the at least one graft-removal patient-specific instrument to be selectively positioned on the bone/cartilage to remove cartilage from the at least one donor location.
Further in accordance with a second embodiment of the present disclosure, there is provided a system for creating a patient-specific instrument model for chondral graft plugging, comprising: a bone model generator for producing a bone/cartilage model of an articular region of a bone from images thereof; a defect geometry identifier for identifying a graft geometry from a defect region of said bone/cartilage model; a donor locator for locating an autograft at at least one donor site or identifying an allograft from a database, using said bone/cartilage model and the graft geometry; and a patient-specific instrument model generator for creating a model of a graft-plugging patient-specific instrument from said bone/cartilage model, and the graft geometry, the graft-plugging patient-specific instrument model comprising a bone/cartilage interface surface shaped as a function of the bone/cartilage model for the at least one graft-plugging patient-specific instrument to be selectively positioned on the bone/cartilage to pose at least one of the autograft and the allograft at the defect region.
Still further in accordance with a third embodiment of the present disclosure, there is provided a method for creating at least one patient-specific instrument model for chondral graft plugging, comprising: determining a graft geometry from a defect region in a bone/cartilage model of an articular region of a bone; identifying at least one of a corresponding allograft and autograft with a donor location from the bone/cartilage model, using the graft geometry; and creating a model of at least one graft-plugging patient-specific instrument using the graft geometry, and the bone/cartilage model, the at least one graft-plugging patient-specific instrument adapted to plug at least one of an autograft and an allograft at the defect region.
Referring to the drawings, and more particularly to
According to 11, the graft geometry is determined from the recipient location, i.e., the chondral articular area requiring the graft. The graft geometry may comprise the dimensions of the required graft, the thickness of the required graft, and the curvature. The graft geometry may be identified by a preoperative step, with non-invasive or minimally invasive techniques being well suited for 11. For instance, imaging technologies such as magnetic-resonance imagery or contrast-enhanced computed tomography of the bone are two of numerous technologies that can used to image chondral defects, by the imaging of bone and chondral tissue. Other methods are contemplated as well.
With the imaging, the chondral defect may be quantified with the geometric details set forth above. Moreover, data is obtained pertaining to the global geometry of the bone and cartilage. The data is used to create a model of an operated site portion of the bone and cartilage including that of an area surrounding the recipient location. Reference will be made hereinafter to the model obtained in 11 as the bone/cartilage model. This will refer to a model of a portion of a bone, with layers thereon distinguishing bone from cartilage.
According to 12, the model of the operated site portion is used to identify donor location. The donor location comprises cartilage that generally matches the geometric details of the required graft. Moreover, the donor location is selected for practical considerations, for instance to minimize post-surgery impact on articular integrity. The donor location may consist of numerous donor sublocations, to create a graft mosaic from cartilage sections that matches the geometry details of the required draft.
According to an embodiment, the graft geometry may match that of available allografts. The graft geometry may therefore be compared to geometries in a database of allografts to determine whether an allograft could be used instead of or in addition to an autograft. The comparison between the modeled graft geometry and the allograft geometry could find compatibility between geometries despite some deviations. Moreover, the allograft database may comprise allografts harvested from surfaces other than that matching the donor site. For example, if appropriate and if geometries match, allografts from shoulder, hip, ankle, and the like could be used for the tibial plateau, etc.
According to 13, PSI is created to remove a graft from the donor location, or to alter an allograft. An example of PSI is provided and detailed hereinafter. The PSI is manufactured specifically for the patient, using the model obtained from the imaging in 11, as well as graft geometry and donor location or sublocations. For autograft removal applications, the PSI has a geometry that is made for precisely and accurately engaging onto the bone and cartilage of the patient for the removal of the graft or graft portions from the donor location or sublocations.
According to 14, PSI may be created to plug the graft obtained from the donor location in the recipient location. Again, the PSI is manufactured specifically for the patient, using the model obtained from the imaging in step 11, as well as recipient location. The PSI has a geometry that is made for precisely and accurately engaging onto the bone and cartilage of the patient for plugging the graft or graft portions at the recipient location. The PSI according to 14 may be used to plug an allograft in the donor location.
Other PSI may be created to perform other tasks. For instance, an instrument could be used to clean (e.g., burr) chondral tissue in the defect region with a view to receiving the graft. The PSI used for such purpose may include a support to hold the appropriate tools in a specific position and/or orientation relative to the tool, to control the cleaning procedure. PSI could be generated to modify allografts as well.
According to 15, graft surgery (i.e., osteoarticular transfer) is performed. Accordingly, steps 11-14 may be performed pre-operatively using proper imaging technologies, to minimize surgical time. Moreover, by the use of PSI, the surgical procedure is performed efficiently, as the PSI is already shaped to the bone model, whereby no extensive calibration is required.
Referring to
The CAS system 20 comprises a CAS processor unit 40 that receives the bone images 30, and that will produce PSI models from the images 30. The CAS processor unit 40 has a processor to run the application that will generate the PSI models. Accordingly, the CAS processor unit 40 may be any appropriate computer or processing unit. User interfaces (e.g., monitor, screen, keyboard, mouse, touch-screen) are part of the CAS processor unit 40, for the involvement of an operator in the creation of the PSI models.
The CAS processor unit 40 comprises a bone model generator 41. The bone model generator 41 is used to interpret the images 30, and thus to create a model of the articular region of the bone. The model distinguishes chondral tissue from the bone, thereby enabling to segment out the chondral tissue from the bone, effectively creating a model of the cartilage on its supporting structure, i.e., the bone. The operator's input may be required in distinguishing cartilage from bone and/or for confirming the proper segmentation between bone and cartilage. The interfaces may be used for this purpose.
A defect geometry identifier 42 uses the model of the cartilage to determine a graft geometry. The defect geometry identifier 42 defines the geometrical parameters of the graft, such as dimensions, thickness, curvature, etc. The operator's input may also be required, for instance to delimit chondral defect from the images.
A donor locator 43 then matches the graft geometry from the defect geometry identifier 42 to the cartilage model of the bone model generator 41. The donor locator 43 locates parts of the cartilage model that could be donor locations or sites, from the geometric data of the required graft. The donor locator 43 may also ensure that the donor site is indeed well suited for the removal of graft, without affecting the articular integrity. For instance, the donor locator 43 may relate the donor site to its location on the bone, with some regions of the bone being excluded from being donor sites.
The donor locator 43 may identify more than one potential donor location, with the operator selecting the donor location among the potential sites. Moreover, the donor locator 43 may identify a plurality of donor sublocations, which sublocations would produce a graft mosaic having the geometry of the defect, i.e., the graft geometry provided by the defect geometry identifier 42.
Still referring to
As mentioned above, the graft geometry may be compared with the geometries of available allografts by the donor locator 43, as shown by 45. If a match is found, an allograft or allografts could be used instead or in addition to autografts. A PSI model or models may be produced for PSI that may alter an allograft or allografts into the graft having an appropriate geometry for the recipient location.
Referring concurrently to
The guide 51 may have an opening slidingly supporting a punch 52, thereby forming a sliding or translational joint 53. According to an embodiment, the translation joint 53 is a prismatic joint, or any appropriate joint that limits the movement of the punch 52 to one degree of freedom (DOF). As another example, a one-DOF pivot joint could relate the punch to the guide. In
The PSI graft remover 50, the PSI graft plugger 60 and other PSI tools 70 have a tooling end at which a tool is located, for performing alterations on cartilage. In
Referring to
The present application claims priority on U.S. Provisional Patent Application No. 61/590,157, incorporated herewith by reference.
Number | Name | Date | Kind |
---|---|---|---|
4841975 | Woolson | Jun 1989 | A |
5098383 | Hemmy et al. | Mar 1992 | A |
5490854 | Fisher et al. | Feb 1996 | A |
5768134 | Swaelens et al. | Jun 1998 | A |
5871018 | Delp et al. | Feb 1999 | A |
5916219 | Matsuno et al. | Jun 1999 | A |
7357057 | Chiang | Apr 2008 | B2 |
7468075 | Lang et al. | Dec 2008 | B2 |
7510557 | Bonutti | Mar 2009 | B1 |
7534263 | Burdulis | May 2009 | B2 |
7618451 | Berez et al. | Nov 2009 | B2 |
7634119 | Tsougarakis et al. | Dec 2009 | B2 |
7717956 | Lang | May 2010 | B2 |
7796791 | Tsougarakis et al. | Sep 2010 | B2 |
7799077 | Lang et al. | Sep 2010 | B2 |
7806896 | Bonutti | Oct 2010 | B1 |
7806897 | Bonutti | Oct 2010 | B1 |
7967868 | White et al. | Jun 2011 | B2 |
7981158 | Fitz et al. | Jul 2011 | B2 |
8062302 | Lang et al. | Nov 2011 | B2 |
8066708 | Lang et al. | Nov 2011 | B2 |
8070752 | Metzger et al. | Dec 2011 | B2 |
8077950 | Tsougarakis et al. | Dec 2011 | B2 |
8083745 | Lang et al. | Dec 2011 | B2 |
8092465 | Metzger et al. | Jan 2012 | B2 |
8094900 | Steines et al. | Jan 2012 | B2 |
8105330 | Fitz et al. | Jan 2012 | B2 |
8122582 | Burdulis, Jr. et al. | Feb 2012 | B2 |
8133234 | Meridew et al. | Mar 2012 | B2 |
8160345 | Pavlovskaia et al. | Apr 2012 | B2 |
8175683 | Roose | May 2012 | B2 |
8221430 | Park et al. | Jul 2012 | B2 |
8234097 | Steines et al. | Jul 2012 | B2 |
8241293 | Stone et al. | Aug 2012 | B2 |
8282646 | Schoenefeld et al. | Oct 2012 | B2 |
8298237 | Schoenefeld | Oct 2012 | B2 |
8337501 | Fitz et al. | Dec 2012 | B2 |
8337507 | Lang et al. | Dec 2012 | B2 |
8343218 | Lang et al. | Jan 2013 | B2 |
8366771 | Burdulis et al. | Feb 2013 | B2 |
8377129 | Fitz et al. | Feb 2013 | B2 |
8439926 | Bojarski et al. | May 2013 | B2 |
8444651 | Kunz | May 2013 | B2 |
8460304 | Fitz et al. | Jun 2013 | B2 |
8480754 | Bojarski et al. | Jul 2013 | B2 |
8500740 | Bojarski et al. | Aug 2013 | B2 |
8529568 | Bouadi | Sep 2013 | B2 |
8529630 | Bojarski | Sep 2013 | B2 |
8585708 | Fitz et al. | Sep 2013 | B2 |
8545569 | Fitz et al. | Oct 2013 | B2 |
8551099 | Lang | Oct 2013 | B2 |
8551102 | Fitz et al. | Oct 2013 | B2 |
8551103 | Fitz et al. | Oct 2013 | B2 |
8551169 | Fitz et al. | Oct 2013 | B2 |
8556906 | Fitz et al. | Oct 2013 | B2 |
8556907 | Fitz et al. | Oct 2013 | B2 |
8556971 | Lang | Oct 2013 | B2 |
8556983 | Bojarski et al. | Oct 2013 | B2 |
8561278 | Fitz et al. | Oct 2013 | B2 |
8562611 | Fitz et al. | Oct 2013 | B2 |
8562618 | Fitz et al. | Oct 2013 | B2 |
8568479 | Fitz et al. | Oct 2013 | B2 |
8568480 | Fitz et al. | Oct 2013 | B2 |
8617172 | Fitz et al. | Dec 2013 | B2 |
8617242 | Philipp | Dec 2013 | B2 |
8623026 | Wong et al. | Jan 2014 | B2 |
8634617 | Tsougarakis et al. | Jan 2014 | B2 |
8638998 | Steines et al. | Jan 2014 | B2 |
8641716 | Fitz et al. | Feb 2014 | B2 |
8657827 | Fitz et al. | Feb 2014 | B2 |
8682052 | Fitz et al. | Mar 2014 | B2 |
20020157676 | Schmieding | Oct 2002 | A1 |
20030055502 | Lang et al. | Mar 2003 | A1 |
20030216669 | Lang et al. | Nov 2003 | A1 |
20040133276 | Lang et al. | Jul 2004 | A1 |
20040138754 | Lang et al. | Jul 2004 | A1 |
20040147927 | Tsougarakis et al. | Jul 2004 | A1 |
20040153079 | Tsougarakis et al. | Aug 2004 | A1 |
20040204644 | Tsougarakis et al. | Oct 2004 | A1 |
20040204760 | Fitz et al. | Oct 2004 | A1 |
20040236424 | Berez et al. | Nov 2004 | A1 |
20050234461 | Burdulis et al. | Oct 2005 | A1 |
20050267584 | Burdulis et al. | Dec 2005 | A1 |
20060111722 | Bouadi | May 2006 | A1 |
20070083266 | Lang | Apr 2007 | A1 |
20070093896 | Malinin | Apr 2007 | A1 |
20070100462 | Lang et al. | May 2007 | A1 |
20070156171 | Lang et al. | Jul 2007 | A1 |
20070157783 | Chiang | Jul 2007 | A1 |
20070198022 | Lang et al. | Aug 2007 | A1 |
20070226986 | Park et al. | Oct 2007 | A1 |
20070233141 | Park et al. | Oct 2007 | A1 |
20070233269 | Steines et al. | Oct 2007 | A1 |
20070250169 | Lang | Oct 2007 | A1 |
20080114370 | Schoenefeld | May 2008 | A1 |
20080147072 | Park et al. | Jun 2008 | A1 |
20080161815 | Schoenefeld et al. | Jul 2008 | A1 |
20080195216 | Philipp | Aug 2008 | A1 |
20080243127 | Lang et al. | Oct 2008 | A1 |
20080275452 | Lang et al. | Nov 2008 | A1 |
20080281328 | Lang et al. | Nov 2008 | A1 |
20080281329 | Fitz et al. | Nov 2008 | A1 |
20080281426 | Fitz et al. | Nov 2008 | A1 |
20080287954 | Kunz et al. | Nov 2008 | A1 |
20090024131 | Metzgu et al. | Jan 2009 | A1 |
20090088753 | Aram et al. | Apr 2009 | A1 |
20090088754 | Aker et al. | Apr 2009 | A1 |
20090088755 | Aker et al. | Apr 2009 | A1 |
20090088758 | Bennett | Apr 2009 | A1 |
20090088759 | Aram et al. | Apr 2009 | A1 |
20090088760 | Aram et al. | Apr 2009 | A1 |
20090088761 | Roose et al. | Apr 2009 | A1 |
20090088763 | Aram et al. | Apr 2009 | A1 |
20090093816 | Roose et al. | Apr 2009 | A1 |
20090099567 | Zajac | Apr 2009 | A1 |
20090110498 | Park et al. | Apr 2009 | A1 |
20090131941 | Park et al. | May 2009 | A1 |
20090131942 | Aker et al. | May 2009 | A1 |
20090138020 | Park et al. | May 2009 | A1 |
20090157083 | Park et al. | Jun 2009 | A1 |
20090209962 | Jamali | Aug 2009 | A1 |
20090222014 | Bojarksi et al. | Sep 2009 | A1 |
20090222016 | Park et al. | Sep 2009 | A1 |
20090222103 | Fitz et al. | Sep 2009 | A1 |
20090226068 | Fitz et al. | Sep 2009 | A1 |
20090228113 | Lang et al. | Sep 2009 | A1 |
20090254093 | White et al. | Oct 2009 | A1 |
20090270868 | Park et al. | Oct 2009 | A1 |
20090276045 | Lang | Nov 2009 | A1 |
20090306676 | Lang et al. | Dec 2009 | A1 |
20090307893 | Burdulis, Jr. et al. | Dec 2009 | A1 |
20090312805 | Lang et al. | Dec 2009 | A1 |
20100023015 | Park | Jan 2010 | A1 |
20100042105 | Park et al. | Feb 2010 | A1 |
20100049195 | Park et al. | Feb 2010 | A1 |
20100054572 | Tsougarakis et al. | Mar 2010 | A1 |
20100082035 | Keefer | Apr 2010 | A1 |
20100087829 | Metzger et al. | Apr 2010 | A1 |
20100152741 | Park et al. | Jun 2010 | A1 |
20100152782 | Stone et al. | Jun 2010 | A1 |
20100160917 | Fitz et al. | Jun 2010 | A1 |
20100168754 | Fitz et al. | Jul 2010 | A1 |
20100174376 | Lang et al. | Jul 2010 | A1 |
20100185202 | Lester et al. | Jul 2010 | A1 |
20100191244 | White et al. | Jul 2010 | A1 |
20100212138 | Carroll et al. | Aug 2010 | A1 |
20100217270 | Polinski et al. | Aug 2010 | A1 |
20100217338 | Carroll et al. | Aug 2010 | A1 |
20100228257 | Bonutti | Sep 2010 | A1 |
20100234849 | Bouadi | Sep 2010 | A1 |
20100256479 | Park et al. | Oct 2010 | A1 |
20100262150 | Lian | Oct 2010 | A1 |
20100274534 | Steines et al. | Oct 2010 | A1 |
20100281678 | Burdulis, Jr. et al. | Nov 2010 | A1 |
20100286700 | Snider et al. | Nov 2010 | A1 |
20100298894 | Bojarski et al. | Nov 2010 | A1 |
20100303313 | Lang et al. | Dec 2010 | A1 |
20100303317 | Tsougarakis et al. | Dec 2010 | A1 |
20100303324 | Lang et al. | Dec 2010 | A1 |
20100305573 | Fitz et al. | Dec 2010 | A1 |
20100305574 | Fitz et al. | Dec 2010 | A1 |
20100305708 | Lang et al. | Dec 2010 | A1 |
20100305907 | Fitz et al. | Dec 2010 | A1 |
20100329530 | Lang et al. | Dec 2010 | A1 |
20110015636 | Katrana et al. | Jan 2011 | A1 |
20110015637 | De Smedt et al. | Jan 2011 | A1 |
20110015639 | Metzger et al. | Jan 2011 | A1 |
20110029091 | Bojarski et al. | Feb 2011 | A1 |
20110029093 | Bojarski et al. | Feb 2011 | A1 |
20110040168 | Arnaud et al. | Feb 2011 | A1 |
20110054478 | Vanasse et al. | Mar 2011 | A1 |
20110060341 | Angibaud et al. | Mar 2011 | A1 |
20110066193 | Lang et al. | Mar 2011 | A1 |
20110066245 | Lang et al. | Mar 2011 | A1 |
20110071533 | Metzger et al. | Mar 2011 | A1 |
20110071581 | Lang et al. | Mar 2011 | A1 |
20110071645 | Bojarski et al. | Mar 2011 | A1 |
20110071802 | Bojarski et al. | Mar 2011 | A1 |
20110087332 | Bojarski et al. | Apr 2011 | A1 |
20110092977 | Salehi et al. | Apr 2011 | A1 |
20110093108 | Ashby et al. | Apr 2011 | A1 |
20110106093 | Romano et al. | May 2011 | A1 |
20110125003 | Reach | May 2011 | A1 |
20110144760 | Wong et al. | Jun 2011 | A1 |
20110160736 | Meridew et al. | Jun 2011 | A1 |
20110160867 | Meridew et al. | Jun 2011 | A1 |
20110166578 | Stone et al. | Jul 2011 | A1 |
20110172672 | Dubeau et al. | Jul 2011 | A1 |
20110184419 | Meridew et al. | Jul 2011 | A1 |
20110196377 | Hodorek et al. | Aug 2011 | A1 |
20110213368 | Fitz et al. | Sep 2011 | A1 |
20110213373 | Fitz et al. | Sep 2011 | A1 |
20110213374 | Fitz et al. | Sep 2011 | A1 |
20110213376 | Maxson et al. | Sep 2011 | A1 |
20110213377 | Lang et al. | Sep 2011 | A1 |
20110213427 | Fitz et al. | Sep 2011 | A1 |
20110213428 | Fitz et al. | Sep 2011 | A1 |
20110213429 | Lang et al. | Sep 2011 | A1 |
20110213430 | Lang et al. | Sep 2011 | A1 |
20110213431 | Fitz et al. | Sep 2011 | A1 |
20110214279 | Park et al. | Sep 2011 | A1 |
20110218539 | Fitz et al. | Sep 2011 | A1 |
20110218545 | Catanzarite et al. | Sep 2011 | A1 |
20110218584 | Fitz et al. | Sep 2011 | A1 |
20110224674 | White et al. | Sep 2011 | A1 |
20110230888 | Lang et al. | Sep 2011 | A1 |
20110238073 | Lang et al. | Sep 2011 | A1 |
20110245835 | Dodds et al. | Oct 2011 | A1 |
20110266265 | Lang | Nov 2011 | A1 |
20110295329 | Fitz et al. | Dec 2011 | A1 |
20110295378 | Bojarski | Dec 2011 | A1 |
20110313423 | Lang et al. | Dec 2011 | A1 |
20110313424 | Bono et al. | Dec 2011 | A1 |
20110319745 | Frey | Dec 2011 | A1 |
20110319897 | Lang et al. | Dec 2011 | A1 |
20110319900 | Lang et al. | Dec 2011 | A1 |
20120010711 | Antonyshyn et al. | Jan 2012 | A1 |
20120029520 | Lang et al. | Feb 2012 | A1 |
20120041445 | Roose et al. | Feb 2012 | A1 |
20120041446 | Wong et al. | Feb 2012 | A1 |
20120065640 | Metzger et al. | Mar 2012 | A1 |
20120066892 | Lang et al. | Mar 2012 | A1 |
20120071881 | Lang et al. | Mar 2012 | A1 |
20120071882 | Lang et al. | Mar 2012 | A1 |
20120071883 | Lang et al. | Mar 2012 | A1 |
20120072185 | Lang et al. | Mar 2012 | A1 |
20120078254 | Ashby et al. | Mar 2012 | A1 |
20120078258 | Lo et al. | Mar 2012 | A1 |
20120078259 | Meridew | Mar 2012 | A1 |
20120093377 | Tsougarakis et al. | Apr 2012 | A1 |
20120101503 | Lang et al. | Apr 2012 | A1 |
20120109138 | Meridew et al. | May 2012 | A1 |
20120116203 | Vancraen et al. | May 2012 | A1 |
20120116562 | Agnihotri et al. | May 2012 | A1 |
20120123422 | Agnihotri et al. | May 2012 | A1 |
20120123423 | Fryman | May 2012 | A1 |
20120130382 | Iannotti et al. | May 2012 | A1 |
20120130687 | Otto et al. | May 2012 | A1 |
20120141034 | Iannotti et al. | Jun 2012 | A1 |
20120143197 | Lang et al. | Jun 2012 | A1 |
20120150030 | Reach, Jr. | Jun 2012 | A1 |
20120151730 | Fitz et al. | Jun 2012 | A1 |
20120158001 | Burdulis, Jr. et al. | Jun 2012 | A1 |
20120165820 | De Smedt et al. | Jun 2012 | A1 |
20120172884 | Zheng et al. | Jul 2012 | A1 |
20120191205 | Bojarski et al. | Jul 2012 | A1 |
20120191420 | Bojarski et al. | Jul 2012 | A1 |
20120192401 | Pavlovskaia et al. | Aug 2012 | A1 |
20120197260 | Fitz et al. | Aug 2012 | A1 |
20120197408 | Lang et al. | Aug 2012 | A1 |
20120201440 | Steines et al. | Aug 2012 | A1 |
20120209276 | Schuster | Aug 2012 | A1 |
20120209394 | Bojarski et al. | Aug 2012 | A1 |
20120215226 | Bonutti | Aug 2012 | A1 |
20120221008 | Carroll et al. | Aug 2012 | A1 |
20120226283 | Meridew et al. | Sep 2012 | A1 |
20120232669 | Bojarski et al. | Sep 2012 | A1 |
20120232670 | Bojarski et al. | Sep 2012 | A1 |
20120232671 | Bojarski | Sep 2012 | A1 |
20120239045 | Li | Sep 2012 | A1 |
20120245647 | Kunz et al. | Sep 2012 | A1 |
20120245699 | Lang et al. | Sep 2012 | A1 |
20120265208 | Smith | Oct 2012 | A1 |
20120271366 | Katrana et al. | Oct 2012 | A1 |
20120276509 | Iannotti et al. | Nov 2012 | A1 |
20120277751 | Catanzarite et al. | Nov 2012 | A1 |
20120289966 | Fitz et al. | Nov 2012 | A1 |
20120296337 | Fitz et al. | Nov 2012 | A1 |
20130006250 | Metzger | Jan 2013 | A1 |
20130018379 | Fitz et al. | Jan 2013 | A1 |
20130018380 | Fitz et al. | Jan 2013 | A1 |
20130018464 | Fitz et al. | Jan 2013 | A1 |
20130023884 | Fitz et al. | Jan 2013 | A1 |
20130024000 | Bojarski et al. | Jan 2013 | A1 |
20130030419 | Fitz et al. | Jan 2013 | A1 |
20130030441 | Fitz et al. | Jan 2013 | A1 |
20130079781 | Fitz et al. | Mar 2013 | A1 |
20130079876 | Fitz et al. | Mar 2013 | A1 |
20130081247 | Fitz et al. | Apr 2013 | A1 |
20130096562 | Fitz et al. | Apr 2013 | A1 |
20130103363 | Lang et al. | Apr 2013 | A1 |
20130110471 | Lang et al. | May 2013 | A1 |
20130123792 | Fitz et al. | May 2013 | A1 |
20130184713 | Bojarski et al. | Jul 2013 | A1 |
20130197870 | Steines et al. | Aug 2013 | A1 |
20130211409 | Burdulis, Jr. et al. | Aug 2013 | A1 |
20130211410 | Landes et al. | Aug 2013 | A1 |
20130211531 | Steines | Aug 2013 | A1 |
20130245803 | Lang | Sep 2013 | A1 |
20130253522 | Bojarski et al. | Sep 2013 | A1 |
20130289570 | Chao | Oct 2013 | A1 |
20130296874 | Chao | Nov 2013 | A1 |
20130297031 | Hafez | Nov 2013 | A1 |
20130317511 | Bojarski et al. | Nov 2013 | A1 |
20130331850 | Bojarski et al. | Dec 2013 | A1 |
20140005792 | Lang et al. | Jan 2014 | A1 |
20140029814 | Fitz et al. | Jan 2014 | A1 |
20140031826 | Bojarski et al. | Jan 2014 | A1 |
20140039631 | Bojarski et al. | Feb 2014 | A1 |
20140058396 | Fitz et al. | Feb 2014 | A1 |
20140058397 | Fitz et al. | Feb 2014 | A1 |
20140066935 | Fitz et al. | Mar 2014 | A1 |
20140066936 | Fitz et al. | Mar 2014 | A1 |
20140074441 | Fitz et al. | Mar 2014 | A1 |
20140086780 | Miller et al. | Mar 2014 | A1 |
20140142643 | Bake | May 2014 | A1 |
20140228860 | Steines | Aug 2014 | A1 |
Number | Date | Country |
---|---|---|
2004293091 | Jun 2005 | AU |
2004293104 | Jun 2005 | AU |
2005309692 | Jun 2006 | AU |
2005311558 | Jun 2006 | AU |
2002310193 | Mar 2007 | AU |
2006297137 | Apr 2007 | AU |
2002310193 | May 2007 | AU |
2007202573 | Jun 2007 | AU |
2007212033 | Aug 2007 | AU |
2007226924 | Sep 2007 | AU |
2009221773 | Sep 2009 | AU |
2009246474 | Nov 2009 | AU |
2010201200 | Apr 2010 | AU |
2011203237 | Jul 2011 | AU |
2010217903 | Sep 2011 | AU |
2010236263 | Nov 2011 | AU |
2010264466 | Feb 2012 | AU |
2010289706 | Mar 2012 | AU |
2010315099 | May 2012 | AU |
2010327987 | Jun 2012 | AU |
2011203237 | Oct 2012 | AU |
2012216829 | Oct 2012 | AU |
2012217654 | Oct 2013 | AU |
2007212033 | Jan 2014 | AU |
2014200073 | Jan 2014 | AU |
2012289973 | Mar 2014 | AU |
2012296556 | Mar 2014 | AU |
2501041 | Apr 2004 | CA |
2505371 | May 2004 | CA |
2505419 | Jun 2004 | CA |
2506849 | Jun 2004 | CA |
2546958 | Jun 2005 | CA |
2546965 | Jun 2005 | CA |
2804883 | Jun 2005 | CA |
2588907 | Jun 2006 | CA |
2590534 | Jun 2006 | CA |
2623834 | Apr 2007 | CA |
2641241 | Aug 2007 | CA |
2646288 | Sep 2007 | CA |
2717760 | Sep 2009 | CA |
2765499 | Dec 2010 | CA |
2771573 | Mar 2011 | CA |
2779283 | May 2011 | CA |
2782137 | Jun 2011 | CA |
2546965 | Mar 2013 | CA |
1728976 | Feb 2006 | CN |
1729483 | Feb 2006 | CN |
1729484 | Feb 2006 | CN |
1913844 | Feb 2007 | CN |
101111197 | Jan 2008 | CN |
101384230 | Mar 2009 | CN |
101442960 | May 2009 | CN |
100502808 | Jun 2009 | CN |
102006841 | Apr 2011 | CN |
102125448 | Jul 2011 | CN |
102405032 | Apr 2012 | CN |
102448394 | May 2012 | CN |
101420911 | Jul 2012 | CN |
102599960 | Jul 2012 | CN |
1913844 | Sep 2012 | CN |
102711670 | Oct 2012 | CN |
102724934 | Oct 2012 | CN |
102805677 | Dec 2012 | CN |
1729483 | Oct 2013 | CN |
103476363 | Dec 2013 | CN |
60336002 D1 | Mar 2011 | DE |
60239674 D1 | May 2011 | DE |
602004032166 D1 | May 2011 | DE |
602005027391 D1 | May 2011 | DE |
1555962 | Jul 2005 | EP |
1558181 | Aug 2005 | EP |
1567985 | Aug 2005 | EP |
1575460 | Sep 2005 | EP |
1686930 | Aug 2006 | EP |
1686931 | Aug 2006 | EP |
1389980 | Apr 2007 | EP |
1814491 | Aug 2007 | EP |
1833387 | Sep 2007 | EP |
1686930 | Oct 2007 | EP |
1686931 | Jan 2008 | EP |
1928359 | Jun 2008 | EP |
1951136 | Aug 2008 | EP |
1981409 | Oct 2008 | EP |
1996121 | Dec 2008 | EP |
2114312 | Nov 2009 | EP |
2124764 | Dec 2009 | EP |
1928359 | Oct 2010 | EP |
2259753 | Dec 2010 | EP |
2265199 | Dec 2010 | EP |
1555962 | Feb 2011 | EP |
2292188 | Mar 2011 | EP |
2292189 | Mar 2011 | EP |
1389980 | Apr 2011 | EP |
1686930 | Apr 2011 | EP |
1833387 | Apr 2011 | EP |
2303193 | Apr 2011 | EP |
2316357 | May 2011 | EP |
2324799 | May 2011 | EP |
2335654 | Jun 2011 | EP |
2403434 | Jan 2012 | EP |
2405865 | Jan 2012 | EP |
2419035 | Feb 2012 | EP |
2265199 | Mar 2012 | EP |
2303193 | Mar 2012 | EP |
2259753 | Apr 2012 | EP |
2292188 | May 2012 | EP |
2292189 | May 2012 | EP |
2445451 | May 2012 | EP |
2470126 | Jul 2012 | EP |
2496183 | Sep 2012 | EP |
2509539 | Oct 2012 | EP |
2512381 | Oct 2012 | EP |
2324799 | Jan 2013 | EP |
2419035 | Jan 2013 | EP |
2445451 | Mar 2013 | EP |
2564792 | Mar 2013 | EP |
2403434 | Apr 2013 | EP |
2591756 | May 2013 | EP |
2496183 | Dec 2013 | EP |
2512381 | Dec 2013 | EP |
2649951 | Dec 2013 | EP |
2649951 | Dec 2013 | EP |
2671520 | Dec 2013 | EP |
2671521 | Dec 2013 | EP |
2671522 | Dec 2013 | EP |
2114312 | Jan 2014 | EP |
2710967 | Mar 2014 | EP |
2484042 | Mar 2012 | GB |
2489884 | Oct 2012 | GB |
201213674 | Oct 2012 | GB |
2484042 | Mar 2014 | GB |
1059882 | Aug 2011 | HK |
1072710 | Aug 2011 | HK |
1087324 | Nov 2011 | HK |
1104776 | Nov 2011 | HK |
2006510403 | Mar 2006 | JP |
2007514470 | Jun 2007 | JP |
2011519713 | Jul 2011 | JP |
2011224384 | Nov 2011 | JP |
2012091033 | May 2012 | JP |
2012176318 | Sep 2012 | JP |
5053515 | Oct 2012 | JP |
2012187415 | Oct 2012 | JP |
2012523897 | Oct 2012 | JP |
5074036 | Nov 2012 | JP |
2012531265 | Dec 2012 | JP |
2013503007 | Jan 2013 | JP |
5148284 | Feb 2013 | JP |
5198069 | May 2013 | JP |
2014000425 | Jan 2014 | JP |
20050072500 | Jul 2005 | KR |
20050084024 | Aug 2005 | KR |
20120090997 | Aug 2012 | KR |
20120102576 | Sep 2012 | KR |
2012007140 | Jan 2013 | MX |
597261 | Nov 2013 | NZ |
173840 | Sep 2011 | SG |
175229 | Nov 2011 | SG |
176833 | Jan 2012 | SG |
178836 | Apr 2012 | SG |
193484 | Oct 2013 | SG |
200509870 | Mar 2005 | TW |
1231755 | May 2005 | TW |
200800123 | Jan 2008 | TW |
1330075 | Sep 2010 | TW |
2004049981 | Jun 2004 | WO |
2004051301 | Jun 2004 | WO |
2005051239 | Jun 2005 | WO |
2005051240 | Jun 2005 | WO |
2006058057 | Jun 2006 | WO |
2006060795 | Jun 2006 | WO |
2006058057 | Jul 2006 | WO |
2007041375 | Apr 2007 | WO |
2007062103 | May 2007 | WO |
2007092841 | Aug 2007 | WO |
2007109641 | Sep 2007 | WO |
2007092841 | Nov 2007 | WO |
2007109641 | Dec 2007 | WO |
2008101090 | Aug 2008 | WO |
2008112996 | Sep 2008 | WO |
2008101090 | Nov 2008 | WO |
2008157412 | Dec 2008 | WO |
2007041375 | Apr 2009 | WO |
2008157412 | Apr 2009 | WO |
2009111626 | Sep 2009 | WO |
2009111639 | Sep 2009 | WO |
2009111656 | Sep 2009 | WO |
2009140294 | Nov 2009 | WO |
2009154691 | Dec 2009 | WO |
2009111626 | Jan 2010 | WO |
2010099231 | Sep 2010 | WO |
2010099353 | Sep 2010 | WO |
2010121147 | Oct 2010 | WO |
2010099231 | Nov 2010 | WO |
2011008968 | Jan 2011 | WO |
2011028624 | Mar 2011 | WO |
2011056995 | May 2011 | WO |
2011072235 | Jun 2011 | WO |
2011075697 | Jun 2011 | WO |
2011056995 | Sep 2011 | WO |
2011075697 | Oct 2011 | WO |
2011072235 | Dec 2011 | WO |
2011156748 | Dec 2011 | WO |
2012112694 | Aug 2012 | WO |
2012112694 | Aug 2012 | WO |
2012112698 | Aug 2012 | WO |
2012112701 | Aug 2012 | WO |
2012112702 | Aug 2012 | WO |
2012112694 | Jan 2013 | WO |
2012112701 | Jan 2013 | WO |
2012112702 | Jan 2013 | WO |
2013020026 | Feb 2013 | WO |
2013025814 | Feb 2013 | WO |
2012112698 | Mar 2013 | WO |
2013056036 | Apr 2013 | WO |
2013119790 | Aug 2013 | WO |
2013119865 | Aug 2013 | WO |
2013131066 | Sep 2013 | WO |
2013152341 | Oct 2013 | WO |
2013155500 | Oct 2013 | WO |
2013155501 | Oct 2013 | WO |
2014008444 | Jan 2014 | WO |
2014035991 | Mar 2014 | WO |
2014047514 | Mar 2014 | WO |
Entry |
---|
Taylor et al, “Computer-Integrated Surgery, Technology and Clinical Applications”, The MIT Press, Cambridge, MA, London, UK, pp. 451-463. |
Hofmann et al, “Natural-Knee II System”, Intermedics Orthopedics, Austin, TX, 1995. |
Number | Date | Country | |
---|---|---|---|
20130191085 A1 | Jul 2013 | US |
Number | Date | Country | |
---|---|---|---|
61590157 | Jan 2012 | US |