Method and System

Abstract

The present invention relates to a method for dosing a pharmaceutical product in a packaging machine comprising at least one volumetric dosing unit with a dosing chamber. The method comprises metering a volume of a first component, weighing the first component, introducing the first component into a package and metering a volume of a second component, introduce

Description

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1-9 shows a system for dosing according to the present invention.

Claims

1. A method for dosing a pharmaceutical product contained in a packaging machine, wherein: the machine comprises at least one volumetric dosing unit with a dosing chamber,the pharmaceutical product comprises at least a first component and a second component, andat least one of the components comprises an active ingredient, the method comprising the steps of:metering a volume of the first component,weighing the metered volume of the first component;introducing the metered and weighed volume of the first component into a package;metering a volume of the second component;introducing the metered volume of the second component into the package; andweighing the package containing the first and second components,

2. The method according to claim 1, wherein the dosing chamber has a first slidable part and a second slidable part.

3. The method according to claim 1, further comprising the step of weighing the metered volume of the second component before the second component is introduced to the package.

4. The method according to claim 1, further comprising the step of sealing the package containing the first and second components before the package is weighed.

5. The method according to claim 1, wherein the pharmaceutical product comprises more than two components, andwherein the method comprises weighing a metered volume of at least two of the components before introducing the components into the package.

6. The method according to claim 1, further comprising the step of using the results from the step of weighing the metered volume of the first component in a feed-back loop regulation of the volume metering of the first pharmaceutical component.

7. The method according to claim 6, wherein the feed-back loop regulation is intermittent.

8. The method according to claim 6, wherein the feed-back loop regulation is continuous.

9. The method according to claim 3, wherein the weight of the metered volume of the first component is significantly less than the weight of the metered volume of the second component.

10. The method according to claim 9, wherein the weight ratio between the metered volume of the first and the second components is more than 1:10.

11. The method according to claim 9, wherein the weight ratio between the metered volume of the first and the second components is more than 1:100.

12. The method according to claim 1, wherein the metered volume of the first component is significantly smaller than the metered volume of the second component.

13. The method according to claim 12, wherein the volume ratio between the first and the second components is more than 1:10.

14. The method according to claim 12, wherein the volume ratio between the first and the second components is more than 1:100.

15. The method according to claim 1, wherein the package is a sachet.

16. The method according to claim 15, wherein the sachet is made of aluminum foil.

17. The method according to claim 1, wherein the package is a blister package.

18. The method according to claim 1, wherein the package is a capsule.

19. The method according to claim 1, wherein at least one of the components is in the form of pellets.

20. The method according to claim 1, wherein at least one of the components is a powder.

21. The method according to claim 1, wherein at least one of the components is in the form of granules.

22. A system for dosing a pharmaceutical product comprising at least a first and a second component, the system comprising: at least one volumetric dosing unit for metering a volume of the components and having a dosing chamber,means for introducing the components into a package,means for weighing the components and the package,wherein the weighing means comprises a first weighing unit for weighing the package containing the first and second components, anda second weighing unit for weighing a metered volume of the first component before the first component is introduced into the package.

23. The system according to claim 22, wherein the dosing chamber has a first slidable part and a second slidable part.

24. The system according to claim 22, wherein the system comprises a first volumetric dosing unit for metering a volume of the first component, and a second volumetric dosing unit for metering a volume of the second component.

25. The system according to claim 22, wherein the weighing means further comprises a third weighing unit, for weighing a metered volume of the second component before the second component is introduced into the package.

26. The system according to claim 22, further comprising means for sealing the package containing the first and second components.

27. The system according to claim 25, further comprising means for feed-back loop regulation of the volume metering of the components, wherein the means uses the obtained weight of the metered volume of at least one of the components.

28. The system according to claim 27, wherein the means for feed-back loop regulation performs intermittent regulation of the volume metering of the component during operation of the system.

29. The system according to claim 27, wherein the means for feed-back loop regulation performs continuous regulation of the volume metering of the component during operation of the system.

30. A package containing a pharmaceutical product comprising at least a first and a second component wherein each of the components is dosed by the method according to claim 1.

31. A method for producing a package containing a pharmaceutical product comprising at least a first and a second components wherein the method comprises: dosing the components according to the method of claim 1 into the package; andsealing the package.