Claims
- 1. A method for stimulating immunity comprising administering, to a subject in need of immunity stimulation, a pharmaceutically effective amount of a polypeptide having the amino acid sequence of IL-1.alpha. represented by formula (A) which is modified in that at least one of Asn at the 36 position and Cys at the 141 position is deficient or replaced by another amino acid: ##STR4##
- 2. A method for inhibiting growth of Meth A tumor cells comprising administering, to a subject afflicted with Meth A tumor cells, a pharmaceutically effective amount of a polypeptide having the amino acid sequence of IL-1.alpha. represented by formula (A) which is modified in that at least one of Asn at the 36 position and Cys at the 141 position is deficient or replace by another amino acid: ##STR5##
- 3. A method for promoting production of a cytokine comprising administering, to a subject in need of promotion of production of cytokine, a pharmaceutically effective amount of a polypeptide having the amino acid sequence of IL-1.alpha. represented by formula (A) which is modified in that at least one of Asn at the 36 position and Cys at the 141 position is deficient or replaced by another amino acid: ##STR6##
- 4. A method for preventing or inhibiting radiation injury comprising administering, to a subject prior to exposing said subject to radiation, a pharmaceutically effective amount of a polypeptide having the amino acid sequence of IL-1.alpha. represented by formula (A) which is modified in that at least one of Asn at the 36 position and Cys at the 141 position is deficient or replaced by another amino acid: ##STR7##
Priority Claims (5)
Number |
Date |
Country |
Kind |
61-57885 |
Mar 1986 |
JPX |
|
61-129759 |
Jun 1986 |
JPX |
|
61-148393 |
Jun 1986 |
JPX |
|
61-160250 |
Jul 1986 |
JPX |
|
61-200323 |
Aug 1986 |
JPX |
|
Parent Case Info
This is a Divisional Application of application Ser. No. 07/643,292 filed Jan. 22, 1991 now U.S. Pat. No. 5,371,204; which is a Divisional of U.S. application Ser. No. 07/023,373 filed Mar. 9, 1987, now U.S. Pat. No. 5,008,374.
US Referenced Citations (4)
Non-Patent Literature Citations (6)
Entry |
Sato et al "Recombinant Interleukin 1 Alpha and Beta Stimulate . . . "Biochem. Biophys. Res. Comm. 141 (1):285-291 (Nov. 1986). |
Onozaki et al, "Human Interleukin 1 is a Cytocidal Factor For Several Tumor Cell Lines", J. Immunol. 135(6):3962-3968 (Dec. 1985). |
Nakamura et al, "Antitumor Effect of Recombinant Human Interleukin 1 Alpha Against Murine Syngeneic Tumors", Jpn. J. Cancer Res. 77: 767-773 (Aug. 1986). |
Chu et al, "Role of Interleukin 1 in Antigen-Specific T Cell Proliferation"J. Immunol. 132(3):1311-1316 (Mar. 1984). |
March et al, "Cloning, Sequence and Expression of Two Distinct Human Interleukin-1 Complementary DNAs", Nature, 315(6021):641-647 (1985). |
Wells et al, "Cassette Mutagenesis: An Efficient Method for Generation of Multiple Mutations at Defined Sites", Gene, 34:315-323 (1985). |
Divisions (2)
|
Number |
Date |
Country |
Parent |
643292 |
Jan 1991 |
|
Parent |
23373 |
Mar 1987 |
|