METHOD FOR IMPROVED UTILIZATION OF THE PRODUCTION POTENTIAL OF TRANSGENIC PLANTS

The invention relates to a method for improving the utilization of the production potential of transgenic plants.

In the last years, there has been a marked increase in the proportion of transgenic plants in agriculture, even if regional differences are still noticeable to date. Thus, for example, the proportion of transgenic maize in the USA has doubled from 26% to 52% since 2001, while transgenic maize has hardly been of any practical importance in Germany. However, in other European countries, for example in Spain, the proportion of transgenic maize is already about 12%.

Transgenic plants are employed mainly to utilize the production potential of respective plant varieties in the most favourable manner, at the lowest possible input of production means. The aim of the genetic modification of the plants is in particular the generation of resistance in the plants to certain pests or harmful organisms or else herbicides and also to abiotic stress (for example drought, heat or elevated salt levels). It is also possible to modify a plant genetically to increase certain quality or product features, such as, for example, the content of selected vitamins or oils, or to improve certain fibre properties.

Herbicide resistance or tolerance can be achieved, for example, by incorporating genes into the useful plant for expressing enzymes to detoxify certain herbicides, so that a relatively unimpeded growth of these plants is possible even in the presence of these herbicides for controlling broad-leaved weeds and weed grasses. Examples which may be mentioned are cotton varieties or maize varieties which tolerate the herbicidally active compound glyphosate (Roundup®), (Roundup Ready®, Monsanto) or the herbicides glufosinate or oxynil.

More recently, there has also been the development of useful plants comprising two or more genetic modifications (“stacked transgenic plants” or multiply transgenic crops). Thus, for example, Monsanto has developed multiply transgenic maize varieties which are resistant to the European corn borer (Ostrinia nubilalis) and the Western corn rootworm (Diabrotica virgifera). Also known are maize and cotton crops which are both resistant to the Western corn rootworm and the cotton bollworm and tolerant to the herbicide Roundup®.

It has now been found that the utilization of the production potential of transgenic useful plants can be improved even more by treating the plants with one or more 3-arylpyrrolidine-2,4-dione derivative(s). Here, the term “treatment” includes all measures resulting in a contact between these active compounds and at least one plant part. “Plant parts” are to be understood as meaning all above-ground and below-ground parts and organs of plants, such as shoot, leaf, flower and root, by way of example leaves, needles, stalks, stems, flowers, fruit bodies, fruits and seed, and also roots, tubers and rhizomes. The plant parts also include harvested material and also vegetative and generative propagation material, for example cuttings, tubers, rhizomes, slips and seed.

3-Arylpyrrolidine-2,4-dione derivatives and their herbicidal or insecticidal actions are extensively known from the prior art. Thus, for example, EP-A-355 599 and EP-A-415 211 disclose bicyclic 3-arylpyrrolidine-2,4-dione derivatives. Substituted monocyclic 3-arylpyrrolidine-2,4-dione derivatives are known from EP-A-377 893 and EP-A-442 077. Furthermore known are polycyclic 3-arylpyrrolidine-2,4-dione derivatives (EP-A-442 073) and also tetramic acid derivatives from EP-A-456 063, EP-A-521 334, EP-A-596 298, EP-A-613 884, WO 95/01 997, WO 95/26 954, WO 95/20 572, EP-A-0 668 267, WO 96/25 395, WO 96/35 664, WO 97/01 535, WO 97/02 243, WO 97/36 868, WO 97/43 275, WO 98/05 638, WO 98/06 721, WO 98/25 928, WO 99/16 748, WO 99/24 437, WO 99/43 649, WO 99/48 869, WO 99/55 673, WO 01/09 092, WO 91/17 972, WO 01/23 354, WO 01/74 770, WO 03/013 249, WO 2004/007 448, WO 2004/024 688, WO 04/065 366, WO 04/080 962, WO 04/111 042, WO 05/044 791, WO 05/044 796, WO 05/048 710, WO 05/049 596, WO 05/066 125, WO 05/092 897, WO 06/000 355, WO 06/029799, WO 06/056281 and WO 06/056282.

From these documents, the person skilled in the art will easily be familiar with processes for producing and methods for applying 3-arylpyrrolidine-2,4-dione derivatives (3-APD), and with their action. Accordingly, these documents are incorporated into the present application in their entirety with respect to the active compounds which can be employed according to the invention, and to their preparation and use.

The 3-APD which can be employed according to the invention have the general formula (I), as follows:

in which

X represents halogen, alkyl, alkoxy, haloalkyl, haloalkoxy or cyano,

W, Y and Z independently of one another represent hydrogen, halogen, alkyl, alkoxy, haloalkyl, haloalkoxy or cyano,

A represents hydrogen, in each case optionally halogen-substituted alkyl, alkoxyalkyl, saturated, optionally substituted cycloalkyl in which optionally at least one ring atom is replaced by a heteroatom,

B represents hydrogen or alkyl,

A and B together with the carbon atom to which they are attached represent a saturated or unsaturated substituted or unsubstituted cycle which optionally contains at least one heteroatom,

D represents hydrogen or an optionally substituted radical from the group consisting of alkyl, alkenyl, alkoxyalkyl, saturated cycloalkyl in which optionally one or more ring members are replaced by heteroatoms,

A and D together with the atoms to which they are attached represent a saturated or unsaturated cycle which is unsubstituted or substituted in the A,D moiety and optionally contains at least one heteroatom,

G represents hydrogen (a) or represents one of the groups

- in which
- E represents a metal ion or an ammonium ion,
- L represents oxygen or sulphur,
- M represents oxygen or sulphur,
- R¹represents in each case optionally halogen-substituted alkyl, alkenyl, alkoxyalkyl, alkylhioalkyl, polyalkoxyalkyl or optionally halogen-, alkyl- or alkoxy-substituted cycloalkyl which may be interrupted by at least one heteroatom, represents in each case optionally substituted phenyl, phenylalkyl, hetaryl, phenoxyalkyl or hetaryloxyalkyl,
- R²represents in each case optionally halogen-substituted alkyl, alkenyl, alkoxyalkyl, polyalkoxyalkyl or represents in each case optionally substituted cycloalkyl, phenyl or benzyl,
- R³represents optionally halogen-substituted alkyl or optionally substituted phenyl,
- R⁴and R⁵independently of one another represent in each case optionally halogen-substituted alkyl, alkoxy, alkylamino, dialkylamino, alkylthio, alkenylthio, cycloalkylthio or represent in each case optionally substituted phenyl, benzyl, phenoxy or phenylthio and
- R⁶and R⁷independently of one another represent hydrogen, represent in each case optionally halogen-substituted alkyl, cycloalkyl, alkenyl, alkoxy, alkoxyalkyl, represent optionally substituted phenyl, represent optionally substituted benzyl or together with the nitrogen atom to which they are attached represent an optionally substituted ring which is optionally interrupted by oxygen or sulphur.

In a preferred embodiment of the invention, at least one insecticidally active 3-APD derivative is used for treating transgenic useful plants. For the purpose of the invention, the term “insecticidally active” or “insecticidal” comprises insecticidal, acaricidal, molluscicidal, nematicidal and ovicidal actions, and also a repelling, behaviour-modifying or sterilizing action on pests.

Preferred insecticidally active compounds are compounds of the formula (I), in which

W preferably represents hydrogen, C₁-C₄-alkyl, C₁-C₄-alkoxy, chlorine, bromine or fluorine,
X preferably represents C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-haloalkyl, fluorine, chlorine or bromine,
Y and Z independently of one another preferably represent hydrogen, C₁-C₄-alkyl, halogen, C₁-C₄-alkoxy or C₁-C₄-haloalkyl,
A preferably represents hydrogen or in each case optionally halogen-substituted C₁-C₆-alkyl or C₃-C₈-cycloalkyl,
B preferably represents hydrogen, methyl or ethyl,
A, B and the carbon atom to which they are attached preferably represent saturated C₃-C₆-cycloalkyl in which optionally one ring member is replaced by oxygen or sulphur and which is optionally mono- or disubstituted by C₁-C₄-alkyl, trifluoromethyl or C₁-C₄-alkoxy,
D preferably represents hydrogen, in each case optionally fluorine- or chlorine-substituted C₁-C_o-alkyl, C₃-C₄-alkenyl or C₃-C₆-cycloalkyl,
A and D together preferably represent in each case optionally methyl-substituted C₃-C₄-alkanediyl in which optionally one methylene group is replaced by sulphur,
G preferably represents hydrogen (a) or represents one of the groups

in particular (a), (b), (c) or (g),

- in which
- E represents a metal ion or an ammonium ion,
- L represents oxygen or sulphur and
- M represents oxygen or sulphur
R¹preferably represents in each case optionally halogen-substituted C₁-C₁₀-alkyl, C₂-C₁₀-alkenyl, C₁-C₄-alkoxy-C₁-C₄-alkyl, C₁-C₄-alkylthio-C₁-C₄-alkyl or optionally fluorine-, chlorine-, C₁-C₁-alkyl- or C₁-C₂-alkoxy-substituted C₃-C₆-cycloalkyl, represents optionally fluorine-, chlorine-, bromine-, cyano-, nitro-, C₁-C₄alkyl-, C₁-C₄-alkoxy-, trifluoromethyl- or trifluoromethoxy-substituted phenyl, represents in each case optionally chlorine- or methyl-substituted pyridyl or thienyl,
R²preferably represents in each case optionally fluorine- or chlorine-substituted C₁-C₁₀-alkyl, C₂-C₁₀-alkenyl, C₁-C₄alkoxy-C₂-C₄-alkyl, represents optionally methyl- or methoxy-substituted C₅-C₆-cycloalkyl or represents in each case optionally fluorine-, chlorine-, bromine-, cyano-, nitro-, C₁-C₄-alkyl, C₁-C₄-alkoxy, trifluoromethyl- or trifluoromethoxy-substituted phenyl or benzyl,
R³preferably represents optionally fluorine-substituted C₁-C₄-alkyl or represents in each case optionally fluorine-, chlorine-, bromine-, C₁-C₄-alkyl, C₁-C₄-alkoxy, trifluoromethyl-, trifluoromethoxy-, cyano- or nitro-substituted phenyl,
R⁴preferably represents in each case optionally fluorine- or chlorine-substituted C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-alkylamino, C₁-C₄-alkylthio or represents in each case optionally fluorine-, chlorine-, bromine-, nitro-, cyano-, C₁-C₄alkoxy-, trifluoromethoxy-, C₁-C₄-alkylthio-, C₁-C₄-haloalkylthio-, C₁-C₄-alkyl- or trifluoromethyl-substituted phenyl, phenoxy or phenylthio,
R⁵preferably represents C₁-C₄-alkoxy or C₁-C₄-thioalkyl,

R⁶preferably represents C₁-C₆-alkyl, C₃-C₆-cycloalkyl, C₁-C₆-alkoxy, C₃-C₆-alkenyl, C₁-C₄-alkoxy-C₁-C₄alkyl,

R⁷preferably represents C₁-C₆-alkyl, C₃-C₆-alkenyl or C₁-C₄-alkoxy-C₁-C₄-alkyl,
R⁶and R⁷together preferably represent an optionally methyl- or ethyl-substituted C₃-C₆-alkylene radical in which optionally one carbon atom is replaced by oxygen or sulphur.

Particular preference is given to compounds of the formula (I), in which
W particularly preferably represents hydrogen, methyl, ethyl, chlorine, bromine or methoxy,
X particularly preferably represents chlorine, bromine, methyl, ethyl, propyl, i-propyl, methoxy, ethoxy or trifluoromethyl,
Y and Z particularly preferably independently of one another represent hydrogen, fluorine, chlorine, bromine, methyl, ethyl, propyl, i-propyl, trifluoromethyl or methoxy,
A particularly preferably represents methyl, ethyl, propyl, i-propyl, butyl, i-butyl, sec-butyl, tert-butyl, cyclopropyl, cyclopentyl or cyclohexyl,
B particularly preferably represents hydrogen, methyl or ethyl,
A, B and the carbon atom to which they are attached particularly preferably represent saturated C₆-cycloalkyl in which optionally one ring member is replaced by oxygen and which is optionally monosubstituted by methyl, ethyl, methoxy, ethoxy, propoxy or butoxy,
D particularly preferably represents hydrogen, represents methyl, ethyl, propyl, i-propyl, butyl, i-butyl, allyl, cyclopropyl, cyclopentyl or cyclohexyl,
A and D together particularly preferably represent optionally methyl-substituted C₃-C₄-alkanediyl,
G particularly preferably represents hydrogen (a) or represents one of the groups

- in which
- M represents oxygen or sulphur,

R¹particularly preferably represents C₁-C₈-alkyl, C₂-C₄-alkenyl, methoxymethyl, ethoxymethyl, ethylthiomethyl, cyclopropyl, cyclopentyl or cyclohexyl,
- represents optionally fluorine-, chlorine-, bromine, cyano-, nitro-, methyl-, ethyl-, methoxy-, trifluoromethyl- or trifluoromethoxy-substituted phenyl,
- represents in each case optionally chlorine- or methyl-substituted pyridyl or thienyl,

R²particularly preferably represents C₁-C₈-alkyl, C₂-C₄-alkenyl, methoxyethyl, ethoxyethyl or represents phenyl or benzyl,

R⁶and R⁷independently of one another particularly preferably represent methyl, ethyl or together represent a C₅-alkylene radical in which the C₃-methylene group is replaced by oxygen.

Especially preferred are compounds of the formula (I), in which

W very particularly preferably represents hydrogen or methyl,

X very particularly preferably represents chlorine, bromine or methyl,

Y and Z very particularly preferably independently of one another represent hydrogen, chlorine, bromine or methyl,

A, B and the carbon atom to which they are attached very particularly preferably represent saturated C₆-cycloalkyl in which optionally one ring member is replaced by oxygen and which is optionally monosubstituted by methyl, trifluoromethyl, methoxy, ethoxy, propoxy or butoxy,

G very particularly preferably represents hydrogen (a) or represents one of the groups

- in which
- M represents oxygen or sulphur,

R¹very particularly preferably represents C₁-C₈-alkyl, C₂-C₄-alkenyl, methoxymethyl, ethoxymethyl, ethylthiomethyl, cyclopropyl, cyclopentyl, cyclohexyl or
- represents phenyl which is optionally monosubstituted by fluorine, chlorine, bromine, methyl, methoxy, trifluoromethyl, trifluoromethoxy, cyano or nitro,
- represents in each case optionally chlorine- or methyl-substituted pyridyl or thienyl,

R²very particularly preferably represents C₁-C₈-alkyl, C₂-C₄-alkenyl, methoxyethyl, ethoxyethyl, phenyl or benzyl,

R⁶and R⁷independently of one another very particularly preferably represent methyl, ethyl or together represent a C₅-alkylene radical in which the C₃-methylene group is replaced by oxygen.

Depending on the nature of the substitution, the compounds of the formula (I) may also be present as optical isomers or isomer mixtures of varying compositions.

Especially preferred are compounds of the abovementioned formula (I) in which the radicals are as defined below:

(I)

Exam-

ple

No.
W
X
Y
Z
R
G
m.p. ° C.

I-1
H
Br
H
CH₃
OCH₃
CO-i-C₃H₇
122

I-2
H
Br
H
CH₃
OCH₃
CO₂—C₂H₅
140-142

I-3
H
CH₃
H
CH₃
OCH₃
H
>220

I-4
H
CH₃
H
CH₃
OCH₃
CO₂—C₂H₅
128

I-5
CH₃
CH₃
H
Br
OCH₃
H
>220

I-6
CH₃
CH₃
H
Cl
OCH₃
H
219

I-7
H
Br
CH₃
CH₃
OCH₃
CO-i-C₃H₇
217

I-8
H
CH₃
Cl
CH₃
OCH₃
CO₂C₂H₅
162

I-9
CH₃
CH₃
CH₃
CH₃
OCH₃
H
>220

I-10
CH₃
CH₃
H
Br
OC₂H₅
CO-i-C₃H₇
212-214

I-11
H
CH₃
CH₃
CH₃
OC₂H₅
CO—n-C₃H₇
134

I-12
H
CH₃
CH₃
CH₃
OC₂H₅
CO-i-C₃H₇
108

I-13
H
CH₃
CH₃
CH₃
OC₂H₅
CO—c-C₃H₅
163

in the form of their cis/trans isomer mixtures or their pure cis isomers.

Emphasis is given to the cis isomers of the formulae (I-3) and (I-4)

The compounds of the formula (I) are—as already mentioned above—known to the person skilled in the art, as is their preparation (see in particular WO 97/01 535, WO 97/36 868, WO 98/05 638, WO 04/007 448).

Preference is given to mixtures of two or more, preferably two or three, particularly preferably two, of the insecticidally active compounds.

According to the process proposed according to the invention, transgenic plants, in particular the useful plants, are treated with 3-APD derivatives to increase agricultural productivity. For the purpose of the invention, transgenic plants are plants coding for at least one gene or gene fragment not transferred by fertilization. This gene or gene fragment may originate or be derived from another plant of the same species, from plants of a different species, but also from organisms from the animal kingdom or microorganisms (including viruses) (“foreign gene”) and/or, if appropriate, already have mutations compared to the natural sequence. According to the invention, it is also possible to use synthetic genes, which is also included in the term “foreign gene” here. It is also possible for a transgenic plant to code for two or more foreign genes of different origin.

For the purpose of the invention, the “foreign gene” is further characterized in that it comprises a nucleic acid sequence which has a certain biological or chemical function or activity in the transgenic plant. In general, these genes code for biocatalysts, such as, for example, enzymes or ribozymes, or else they comprise regulatory sequences, such as, for example, promoters or terminators, for controlling the expression of endogenous proteins. However, to this end, they may also code for regulatory proteins, such as, for example, repressors or inductors. Furthermore, the foreign gene may also serve the targeted localization of a gene product of the transgenic plant, coding, for example, for a signal sequence. The foreign gene may also code for inhibitors, such as, for example, antisense RNA.

The person skilled in the art is readily familiar with numerous different methods for producing transgenic plants and methods for the targeted mutagenesis, for gene transformation and cloning, for example from: Willmitzer, 1993, Transgenic plants, in: Biotechnology, A Multivolume Comprehensive Treatise, Rehm et al. (eds.), Vol. 2, 627-659, VCH Weinheim, Germany; McCormick et al., 1986, Plant Cell Reports 5: 81-84; EP-A 0221044; EP-A 0131624, or Sambrook et al., 1989, “Molecular Cloning: A Laboratory Manual”, 3rd Ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.; Winnacker, 1996, “Gene and Klone” [Genes and Clones], 2nd Ed., VCH Weinheim or Christou, 1996, Trends in Plant Science 1: 423-431. Examples of transit or signal peptides or time- or site-specific promoters are disclosed, for example, in Braun et al., 1992, EMBO J. 11: 3219-3227; Wolter et al., 1988, Proc. Natl. Acad. Sci. USA 85: 846-850; Sonnewald et al., 1991, Plant J. 1: 95-106.

An example of a complex genetic manipulation of a useful plant is the so-called GURT technology (“Genetic Use Restriction Technologies”) which allows the technical control of the propagation of the transgenic plant variety in question. To this end, in general two or three foreign genes are cloned into the useful plant which, in a complex interaction after administration of an external stimulus, trigger a cascade resulting in the death of the embryo which would otherwise develop. To this end, the external stimulus (for example an active compound or another chemical or abiotic stimulus) may interact, for example, with a repressor which then no longer suppresses the expression of a recombinase, so that the recombinase is able to cleave an inhibitor thus allowing expression of a toxin causing the embryo to die. Examples of this type of transgenic plants are disclosed in U.S. Pat. No. 5,723,765 or U.S. Pat. No. 5,808,034.

Accordingly, the person skilled in the art is familiar with processes for generating transgenic plants which, by virtue of the integration of regulatory foreign genes and the overexpression, suppression or inhibition of endogenous genes or gene sequences mediated in this manner, if appropriate, or by virtue of the existence or expression of foreign genes or fragments thereof, have modified properties.

As already discussed above, the method according to the invention allows better utilization of the production potential of transgenic plants. On the one hand, this may, if appropriate, be based on the fact that the application rate of the active compound which can be employed according to the invention can be reduced, for example by lowering the dose employed or else by reducing the number of applications. On the other hand, if appropriate, the yield of the useful plants may be increased quantitatively and/or qualitatively. This is true in particular in the case of a transgenically generated resistance to biotic or abiotic stress. If, for example, insecticidal 3-APD are used, the dosage of the insecticide may in certain cases be limited to a sublethal dose, without this resulting in a significant weakening of the desired effect of the active compound on the pests.

Depending on the plant species or plant varieties, their location and the growth conditions (soils, climate, vegetation period, nutrients), these synergistic actions may vary and may be multifarious. Thus possible are, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase of the activity of the compounds and compositions used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering, easier harvesting, accelerated maturation, higher harvest yields, higher quality and/or higher nutrient value of the harvested products, increased storability and/or processibility of the harvested products, which exceed the effects normally to be expected.

These advantages are the result of a synergistic action, achieved according to the invention, between the 3-APD which can be employed and the respective principle of action of the genetic modification of the transgenic plant. This reduction of production means as a result of the synergism, with simultaneous yield or quality increase, is associated with considerable economical and ecological advantages.

A list of examples known to the person skilled in the art of transgenic plants, with the respective affected structure in the plant or the protein expressed by the genetic modification in the plant being mentioned, is compiled in Table 1. Here, the structure in question or the principle expressed is in each case grouped with a certain feature in the sense of a tolerance to a certain stress factor. A similar list (Table 3) compiles—in a slightly different arrangement—likewise examples of principles of action, tolerances induced thereby and possible useful plants. Further examples of transgenic plants suitable for the treatment according to the invention are compiled in Tables 4, and 5 and 6.

In an advantageous embodiment, the 3-APD are used for treating transgenic plants comprising at least one gene or gene fragment coding for a Bt toxin. A Bt toxin is a protein originating from or derived from the soil bacterium Bacillus thuringiensis which either belongs to the group of the crystal toxins (Cry) or the cytolytic toxins (Cyt). In the bacterium, they are originally formed as protoxins and only metabolized in alkaline medium—for example in the digestive tract of certain feed insects—to their active form. There, the active toxin then binds to certain hydrocarbon structures at cell surfaces causing pores to be formed which destroy the osmotic potential of the cell, which may effect cell lysis. The result is the death of the insects. Bt toxins are active in particular against certain harmful species from the orders of the Lepidoptera (butterflies), Homoptera, Diptera and Coleoptera (beetles) in all their development stages; i.e. from the egg larva via their juvenile forms to their adult forms.

It has been known for a long time that gene sequences coding for Bt toxins, parts thereof or else peptides or proteins derived from Bt toxins can be cloned with the aid of genetical engineering into agriculturally useful plants to generate transgenic plants having endogenous resistance to pests sensitive to Bt toxins. For the purpose of the invention, the transgenic plants coding for a Bt toxin or proteins derived therefrom are defined as “Bt plants”.

The “first generation” of such Bt plants generally only comprise the genes enabling the formation of a certain toxin, thus only providing resistance to one group of pathogens. An example of a commercially available maize variety comprising the gene for forming the Cry1Ab toxin is “YieldGard®” from Monsanto which is resistant to the European corn borer. In contrast, in the Bt cotton variety (Bollgard®), resistance to other pathogens from the family of the Lepidoptera is generated by introduction by cloning of the genes for forming the Cry1Ac toxin. Other transgenic crop plants, in turn, express genes for forming Bt toxins with activity against pathogens from the order of the Coleoptera. Examples that may be mentioned are the Bt potato variety “NewLeaf®” (Monsanto) capable of forming the Cry3A toxin, which is thus resistant to the Colorado potato beetle, and the transgenic maize variety “YieldGard®” (Monsanto) which is capable of forming the Cry 3Bb1 toxin and is thus protected against various species of the Western corn rootworm.

In a “second generation”, the multiply transgenic plants, already described above, expressing or comprising at least two foreign genes were generated.

Preference according to the invention is given to transgenic plants with Bt toxins from the group of the Cry family (see, for example, Crickmore et al., 1998, Microbiol. Mol. Biol. Rev. 62: 807-812), which are particularly effective against Lepidoptera, Coleoptera and Diptera. Examples of genes coding for the proteins are:

cry1Aa1, cry1Aa2, cry1Aa3, cry1Aa4, cry1Aa5, cry1Aa6, cry1Aa7, cry1Aa8, cry1Aa9, cry1Aa10, cry1Aa11 cry1Ab1, cry1Ab2, cry1Ab3, cry1Ab4, cry1Ab5, cry1Ab6, cry1Ab7, cry1Ab8, cry1Ab9, cry1Ab10, cry1Ab10, cry1Ab12, cry1Ab13, cry1Ab14, cry1Ac1, cry1Ac2, cry1Ac3, cry1Ac4, cry1Ac5, cry1Ac6, cry1Ac7, cry1Ac8, cry1Ac9, cry1Ac10, cry1Ac11, cry1Ac12, cry1Ac13, cry1Ad1, cry1Ad2, cry1Ae1, cry1Af1, cry1Ag1, cry1Ba1, cry1Ba2, cry1Bb1, cry1Bc1, cry1Bd1, cry1Be1, cry1Ca1, cry1Ca2, cry1Ca3, cry1Ca4, cry1Ca5, cry1Ca6, cry1Ca7, cry1Cb1, cry1Cb2, cry1Da1, cry1Da2, cry1Db1, cry1Ea1, cry1Ea2, cry1Ea3, cry1Ea4, cry1Ea5, cry1Ea6, cry1Eb1, cry1Fa1, cry1Fa2, cry1Fb1, cry1Fb2, cry1Fb3, cry1Fb4, cry1Ga1, cry1Ga2, cry1Gb1, cry1Gb2, cry1Ha1, cry1Hb1, cry1Ia1, cry1Ia2, cry1Ia3, cry1Ia4, cry1Ia5, cry1Ia6, cry1Ja1, cry1Jb1, cry1Jc1, cry1Ka1, cry1-like, cry2Aa1, cry2Aa2, cry2Aa3, cry2Aa4, cry2Aa5, cry2Aa6, cry2Aa7, cry2Aa8, cry2Aa9, cry2Ab1, cry2Ab2, cry2Ab3, cry2Ac1, cry2Ac2, cry2Ad1, cry3Aa1, cry3Aa2, cry3Aa3, cry3Aa4, cry3Aa5, cry3Aa6, cry3Aa7, cry3Ba1, cry3Ba2, cry3Bb1, cry3Bb2, cry3Bb3, cry3Ca1, cry4Aa1, cry4Aa2, cry4Ba1, cry4Ba2, cry4Ba3, cry4Ba4, cry5Aa1, cry5Ab1, cry5Ac1, cry5Ba1, cry6Aa1, cry6Ba1, cry7Aa1, cry7Ab1, cry7Ab2, cry8Aa1, cry8Ba1, cry8Ca1, cry9Aa1, cry9Aa2, cry9Ba1, cry9Ca1, cry9Da1, cry9Da2, cry9Ea1, cry9 like, cry10Aa1, cry10Aa2, cry11Aa1, cry11Aa2, cry11Ba1, cry11Bb1, cry12Aa1, cry13Aa1, cry14Aa1, cry15Aa1, cry16Aa1, cry17Aa1, cry18Aa1, cry18Ba1, cry18Ca1, cry19Aa1, cry19Ba1, cry20Aa1, cry21Aa1, cry21Aa2, cry22Aa1, cry23Aa1, cry24Aa1, cry25Aa1, cry26Aa1, cry27Aa1, cry28Aa1, cry28Aa2, cry29Aa1, cry30Aa1, cry31Aa1, cyt1Aa1, cyt1Aa2, cyt1Aa3, cyt1Aa4, cyt1Ab1, cyt1Ba1, cyt2Aa1, cyt2Ba1, cyt2Ba2, cyt2Ba3, cyt2Ba4, cyt2Ba5, cyt2Ba6, cyt2Ba7, cyt2Ba8, cyt2Bb1.

Particular preference is given to the genes or gene sections of the subfamilies cry1, cry2, cry3, cry5 and cry9; especially preferred are cry1Ab, cry1Ac, cry3A, cry3B and cry9C.

Furthermore, it is preferred to use plants which, in addition to the genes for one or more Bt toxins, express or contain, if appropriate, also genes for expressing, for example, a protease or peptidase inhibitor (such as in WO-A 95/35031), of herbicide resistances (for example to glufosinate or glyphosate by expression of the pat gene or bar gene) or for becoming resistant to nematodes, fungi or viruses (for example by expressing a gluconase, chitinase). However, they may also be modified in their metabolic properties, so that they show a qualitative and/or quantitative change of ingredients (for example by modification of the energy, carbohydrate, fatty acid or nitrogen metabolism or by metabolite currents influencing these (see above).

A list of examples of principles of action which can be introduced by genetic modification into a useful plant and which are suitable for the treatment according to the invention on their own or in combination is compiled in Table 2. Under the header “AP” (active principle), this table contains the respective principle of action and associated therewith the pest to be controlled.

In a particularly preferred variant, the process according to the invention is used for treating transgenic vegetable, maize, soyabean, cotton, tobacco, rice, potato and sugar beet varieties. These are preferably Bt plants.

The vegetable plants or varieties are, for example, the following useful plants:

potatoes: preferably starch potatoes, sweet potatoes and table potatoes;
root vegetables: preferably carrots, turnips (swedes, stubble turnips (Brassica rapa var. rapa), spring turnips, autumn turnips (Brassica campestris ssp. rapifera), Brassica rapa L. ssp. rapa f. teltowiensis), scorzonera, Jerusalem artichoke, turnip-rooted parsley, parsnip, radish and horseradish;
tuber vegetables: preferably kohlrabi, beetroot, celeriac, garden radish;
bulb crops: preferably scallion, leek and onions (planting onions and seed onions);
brassica vegetables: preferably headed cabbage (white cabbage, red cabbage, kale, savoy cabbage), cauliflowers, broccoli, curly kale, marrow-stem kale, seakale and Brussels sprouts;
fruiting vegetables: preferably tomatoes (outdoor tomatoes, vine-ripened tomatoes, beef tomatoes, greenhouse tomatoes, cocktail tomatoes, industrial and fresh market tomatoes), melons, eggplants, aubergines, pepper (sweet pepper and hot pepper, Spanish pepper), chilli pepper, pumpkins, courgettes and cucumbers (outdoor cucumbers, greenhouse cucumbers snake gourds and gherkins);
vegetable pulses: preferably bush beans (as sword beans, string beans, flageolet beans, wax beans, corn beans of green- and yellow-podded cultivars), pole beans (as sword beans, string beans, flageolet beans, wax beans of green-, blue- and yellow-podded cultivars), broadbeans (field beans, Windsor beans, cultivars having white- and black-spotted flowers), peas (chickling vetch, chickpeas, marrow peas, shelling peas, sugar-peas, smooth peas, cultivars having light- and dark-green fresh fruits) and lentils;
green vegetables and stem vegetables: preferably Chinese cabbage, round-headed garden lettuce, curled lettuce, lamb's-lettuce, iceberg lettuce, romaine lettuce, oakleaf lettuce, endives, radicchio, lollo rossa, ruccola lettuce, chicory, spinach, chard (leaf chard and stem chard) and parsley;
other vegetables: preferably asparagus, rhubarb, chives, artichokes, mint varieties, sunflowers, Florence fennel, dill, garden cress, mustard, poppy seed, peanuts, sesame and salad chicory.

Bt vegetables including exemplary methods for preparing them are described in detail, for example, in Barton et al., 1987, Plant Physiol. 85: 1103-1109; Vaeck et al., 1987, Nature 328: 33-37; Fischhoff et al., 1987, Bio/Technology 5: 807-813. In addition, Bt vegetable plants are already known as commercial varieties, for example the potato cultivar NewLeaf® (Monsanto). The preparation of Bt vegetables is also described in U.S. Pat. No. 6,072,105.

Likewise, Bt cotton is already cotton in principle, for example from U.S. Pat. No. 5,322,938 or from Prietro-Samsonór et al., J. Ind. Microbiol. & Biotechn. 1997, 19, 202, and H. Agaisse and D. Lereclus, J. Bacteriol. 1996, 177, 6027. Different varieties of Bt cotton, too, are already commercially available, for example under the name NuCOTN® (Deltapine (USA)). In the context of the present invention, particular preference is given to Bt cotton NuCOTN33® and NuCOTN33B®.

The use and preparation of Bt maize has likewise already been known for a long time, for example from Ishida, Y., Saito, H., Ohta, S., Hiei, Y., Komari, T., and Kumashiro, T. (1996). High efficiency transformation of maize (Zea mayz L.) mediated by Agrobacterium tumefaciens. Nature Biotechnology 4: 745-750. EP-B-0485506, too, describes the preparation of Bt maize plants. Furthermore, different varieties of Bt maize are commercially available, for example under the following names (company/companies is/are in each case given in brackets): KnockOut® (Novartis Seeds), NaturGard® (Mycogen Seeds), Yieldgard® (Novartis Seeds, Monsanto, Cargill, Golden Harvest, Pioneer, DeKalb inter alia), Bt-Xtra® (DeKalb) and StarLink® (Aventis CropScience, Garst inter alia). For the purpose of the present invention, particular preference is given especially to the following maize cultivars: KnockOut®, NaturGard®, Yieldgard®, Bt-Xtra® and StarLink®.

For soyabeans, too, Roundup®Ready cultivar or cultivars resistant to the herbicide Liberty Link® are available and can be treated according to the invention. In the case of rice, a large number of “Golden Rice” lines are available which are likewise characterized in that, by virtue of a transgenic modification, they have an increased content of provitamin A. They, too, are examples of plants which can be treated by the method according to the invention, with the advantages described.

The method according to the invention is suitable for controlling a large number of harmful organisms which occur in particular in vegetables, maize and cotton, in particular insects and arachnids, very particularly preferably insects. The pests mentioned include:

from the order of the Isopoda: for example Armadillidium spp., Oniscus spp., Porcellio spp.
from the order of the Diplopoda: for example Blaniulus spp.
from the order of the Chilopoda for example Geophilus spp., Scutigera spp.
from the order of the Symphyla: for example Scutigerella spp.
from the order of the Thysanura: for example Lepisma spp.
from the order of the Collembola: for example Onychiurus spp.
from the order of the Orthoptera: for example Blattella spp., Periplaneta spp., Leucophaea spp., Acheta spp., Gryllotalpa spp., Locusta migratoria migratorioides, Melanoplus spp., Schistocerca spp.
from the order of the Dermaptera: for example Forficula spp.
from the order of the Isoptera: for example Reticulitermes spp., Reticulitermes spp., Coptotermes spp.
from the order of the Thysanoptera: for example Frankliniella spp., Kakothrips spp., Hercinothrips spp., Scirtothrips spp., Taeniothrips spp., Thrips spp.
from the order of the Heteroptera: for example Eurygaster spp., Stephanitis spp., Lygus spp., Aelia spp., Eurydema spp., Dysdercus spp., Piesma spp.
from the order of the Homoptera: for example Aleurodes spp., Bemisia spp., Trialeurodes spp., Brevicoryne spp., Cryptomyzus spp., Aphis spp., Eriosoma spp., Hyalopterus spp., Phylloxera spp., Pemphigus spp., Macrosiphum spp., Myzus spp., Phorodon spp., Rhopalosiphum spp., Empoasca spp., Euscelis spp., Eulecanium spp., Saissetia spp., Aonidiella spp., Aspidiotus spp., Nephotettix spp., Laodelphax spp., Nilaparvata spp., Sogatella spp., Pseudococcus spp., Psylla spp., Aphrophora spp., Aeneolamia spp., Aphidina ssp.,
from the order of the Lepidoptera: for example Pectinophora spp., Bupalus spp., Chematobia spp., Cnephasia spp., Hydraecia spp., Lithocolletis spp., Hyponomeuta spp., Plutella spp., Plutella xylostella, Malacosoma spp., Euproctis spp., Lymantria spp., Bucculatrix spp., Phytometra spp., Scrobipalpa spp., Phthorimaea spp., Gnorimoschema spp., Autographa spp., Evergestis spp., Lacanobia spp., Cydia spp., Pseudociaphila spp., Phyllocnistis spp., Agrotis spp., Euxoa spp., Feltia spp., Earias spp., Heliothis spp., Helicoverpa spp., Bombyx spp., Laphygma spp., Mamestra spp., Panolis spp., Prodenia spp., Spodoptera spp., Trichoplusia spp., Carpocapsa spp., Pieris spp., Chilo spp., Ostrinia spp., Pyrausta spp., Ephestia spp., Galleria spp., Cacoecia spp., Capua spp., Choristoneura spp., Clysia spp., Hofmannophila spp., Homona spp., Tineola spp., Tinea spp., Tortrix spp.
from the order of the Coleoptera: for example Anobium spp., Rhizopertha spp., Bruchidius spp., Acanthoscelides spp., Hylotrupes spp., Aclypea spp., Agelastica spp., Leptinotarsa spp., Psylliodes spp., Chaetocnema spp., Cassida spp., Bothynoderes spp., Clivina spp., Ceutorhynchus spp., Phyllotreta spp., Apion spp., Sitona spp., Bruchus spp., Phaedon spp., Diabrotica spp., Psylloides spp., Epilachna spp., Atomaria spp., Oryzaephilus spp., Anthonomus spp., Sitophilus spp., Otiorhynchus spp., Cosmopolites spp., Ceuthonynchus spp., Hypera spp., Dermestes spp., Trogoderma spp., Anthrenus spp., Attagenus spp., Lyctus spp., Meligethes spp., Ptinus spp., Niptus spp., Gibbium spp., Tribolium spp., Tenebrio spp., Agriotes spp., Conoderus spp., Melolontha spp., Amphimallon spp., Costelytra spp.
from the order of the Hymenoptera: for example Diprion spp., Hoplocampa spp., Lasius spp., Monomorium spp., Vespa spp.
from the order of the Diptera: for example Drosophila spp., Chrysomyxa spp., Hypoderma spp., Tannia spp., Bibio spp., Oscinella spp., Phorbia spp., Pegomyia spp., Ceratitis spp., Dacus spp., Tipula spp.
from the class of the Arachnida: for example Scorpio maurus, Latrodectus mactans.
from the order of the Acarina: for example Acarus spp., Bryobia spp., Panonychus spp., Tetranychus spp., Eotetranychus spp., Oligonychus spp., Eutetranychus spp., Eriophyes spp., Phyllocoptruta spp., Tarsonemus spp., Rhipicephalus spp., Rhipicephalus spp., Ixodes spp., Amblyomma spp.
from the class of the helminths: for example Meloidogyne spp., Heterodera spp., Globodera spp., Radopholus spp., Pratylenchus spp., Tylenchulus spp., Tylenchorhynchus spp., Rotylenchus spp., Heliocotylenchus spp., Belonoaimus spp., Longidorus spp., Trichodorus spp., Xiphinema spp., Ditylenchus spp., Aphelenchoides spp., Anguina spp.
from the class of the Gastropoda: for example Deroceras spp., Arion spp., Lymnaea spp., Galba spp., Succinea spp.
from the order of the Thysanoptera,
from the order of the Hemiptera: for example species of the sub-order Sternorrhyncha

The method according to the invention is preferably suitable for controlling Agriotes spp., Melolontha spp., Aphis spp., Cnephasia spp., Ostrinia spp., Agrotis spp., Hydraecia spp., Tipula spp., Myzus spp., Bemisia spp., Trialeurodes spp., Oscinella spp., Tetranychus spp., Lygus spp., Leptinotarsa spp., Psylliodes spp., Phytometra spp., Deroceras spp., Psylla spp., Blaniulus spp., Onychiurus spp., Piesma spp., Atomaria spp., Aclypea spp., Chaetocnema spp., Cassida spp., Bothynoderes spp., Clivina spp., Scrobipalpa spp., Phthorimaea spp., Gnorimoschema spp., Mamestra spp., Autographa spp., Arion spp., Gryllotalpa spp., Eurydema spp., Meligethes spp., Ceutorhynchus spp., Phyllotreta spp., Plutella xylostella, Evergestis spp., Lacanobia spp., Pieris spp., Forficula spp., Hypera spp., Apion spp., Otiorhynchus spp., Sitona spp., Acanthoscelides spp., Kakothrips spp., Bruchus spp., Cydia spp., Pseudociaphila spp., Heliothis spp., Helicoverpa spp., Prodenia spp., Spodoptera spp., Chilo spp and Diabrotica spp., Aphindina ssp., Frankliniella spp., Kakothrips spp., Hercinothrips spp., Scirtothrips spp., Taeniothrips spp., Thrips spp., Scorpio maurus, Latrodectus mactans.

The active compounds which can be used according to the invention are particularly suitable for controlling insects from the sub-order of the plant lice (Sternorrhyncha), in particular for controlling gall aphids (Phemphigidae), root aphids, jumping plant lice (Psyllidae), soft scales (Coccidae), armoured scales (Diaspididae), ensign coccids (Ortheziidae) or mealy-bugs (Pseudococcidae). This application is described in detail in WO 2006/077071, which document is incorporated herein by reference in this respect for the purpose of disclosure.

The method according to the invention is particularly suitable for treating Bt vegetables, Bt maize, Bt cotton, Bt soyabeans, Bt tobacco and also Bt rice, Bt sugar beet or Bt potatoes for controlling aphids (Aphidina), whiteflies (Trialeurodes), thrips (Thysanoptera), spider mites (Arachnida), scale insects and mealy-bugs (Coccoidae and Pseudococcoidae).

The active compounds which can be used according to the invention can be employed in customary formulations, such as solutions, emulsions, wettable powders, water- and oil-based suspensions, powders, dusts, pastes, soluble powders, soluble granules, granules for broadcasting, suspoemulsion concentrates, natural compounds impregnated with active compound, synthetic substances impregnated with active compound, fertilizers and also microencapsulations in polymeric substances.

These formulations are prepared in a known manner, for example by mixing the active compounds with extenders, i.e. liquid solvents and/or solid carriers, if appropriate using surfactants, i.e. emulsifiers and/or dispersants and/or foam-formers. The formulations are prepared either in suitable plants or else before or during application.

Wettable powders are preparations which can be dispersed homogeneously in water and which, in addition to the active compound and beside a diluent or inert substance, also comprise wetting agents, for example polyethoxylated alkylphenols, polyethoxylated fatty alcohols, alkylsulphonates or alkylphenylsulphonates and dispersants, for example sodium lignosulphonate, sodium 2,2′-dinaphthylmethane-6,6′-disulphonate.

Dusts are obtained by grinding the active compound with finely distributed solid substances, for example talc, natural clays, such as kaolin, bentonite, pyrophillite or diatomaceous earth. Granules can be prepared either by spraying the active compound onto granular inert material capable of adsorption or by applying active compound concentrates to the surface of carrier substances, such as sand, kaolinites or granular inert material, by means of adhesives, for example polyvinyl alcohol, sodium polyacrylate or mineral oils. Suitable active compounds can also be granulated in the manner customary for the preparation of fertilizer granules—if desired as a mixture with fertilizers.

Suitable for use as auxiliaries are substances which are suitable for imparting to the composition itself and/or to preparations derived therefrom (for example spray liquors, seed dressings) particular properties such as certain technical properties and/or also particular biological properties. Typical suitable auxiliaries are: extenders, solvents and carriers.

Suitable extenders are, for example, water, polar and nonpolar organic chemical liquids, for example from the classes of the aromatic and non-aromatic hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), the alcohols and polyols (which, if appropriate, may also be substituted, etherified and/or esterified), the ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, the unsubstituted and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, the sulphones and sulphoxides (such as dimethyl sulphoxide).

If the extender used is water, it is also possible to employ, for example, organic solvents as auxiliary solvents. Essentially, suitable liquid solvents are: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example petroleum fractions, mineral and vegetable oils, alcohols such as butanol or glycol and also their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethyl sulphoxide, and also water.

Suitable solid carriers are:

for example, ammonium salts and ground natural minerals such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as finely divided silica, alumina and silicates; suitable solid carriers for granules are: for example, crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, and also synthetic granules of inorganic and organic meals, and granules of organic material such as paper, sawdust, coconut shells, maize cobs and tobacco stalks; suitable emulsifiers and/or foam-formers are: for example, nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulphonates, alkyl sulphates, arylsulphonates and also protein hydrolysates; suitable dispersants are nonionic and/or ionic substances, for example from the classes of the alcohol-POE and/or -POP ethers, acid and/or POP POE esters, alkylaryl and/or POP POE ethers, fat and/or POP POE adducts, POE- and/or POP-polyol derivatives, POE- and/or POP-sorbitan or -sugar adducts, alkyl or aryl sulphates, alkyl- or arylsulphonates and alkyl or aryl phosphates or the corresponding PO-ether adducts. Furthermore, suitable oligo- or polymers, for example those derived from vinylic monomers, from acrylic acid, from EO and/or PO alone or in combination with, for example, (poly)alcohols or (poly)amines. It is also possible to employ lignin and its sulphonic acid derivatives, unmodified and modified celluloses, aromatic and/or aliphatic sulphonic acids and their adducts with formaldehyde.

Tackifiers such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or latices, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, as well as natural phospholipids such as cephalins and lecithins, and synthetic phospholipids, can be used in the formulations.

It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestuffs and metal phthalocyanine dyestuffs, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

Other possible additives are perfumes, mineral or vegetable, optionally modified oils, waxes and nutrients (including trace nutrients), such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

Stabilizers, such as low-temperature stabilizers, preservatives, antioxidants, light stabilizers or other agents which improve chemical and/or physical stability may also be present.

These individual types of formulation are known in principle and are described, for example, in: Winnacker-Küchler, 1986, “Chemische Technologie” [Chemical Technology], Volume 7, 4th Ed., C. Hauser Verlag Munich; van Falkenberg, 1972-73, “Pesticides Formulations”, 2nd Ed., Marcel Dekker N.Y.; Martens, 1979, “Spray Drying Handbook”, 3rd Ed., G. Goodwin Ltd. London.

Based on his general expert knowledge, the person skilled in the art is able to choose suitable formulation auxiliaries (in this context, see, for example, Watkins, “Handbook of Insecticide Dust Diluents and Carriers”, 2nd Ed., Darland Books, Caldwell N.J.; v. Olphen, “Introduction to Clay Colloid Chemistry”, 2nd Ed., J. Wiley & Sons, N.Y.; Marsden, “Solvents Guide”, 2nd Ed., Interscience, N.Y. 1950; McCutcheon's, “Detergents and Emulsifiers Annual”, MC Publ. Corp., Ridgewood, N.J.; Sisley and Wood, “Encyclopedia of Surface Active Agents”, Chem. Publ. Co. Inc., N.Y. 1964; Schönfeldt, “Grenzflächenaktive Äthylenoxidaddukte” [Surface-active Ethylene Oxide Adducts], Wiss. Verlagsgesell., Stuttgart 1967; Winnacker-Küchler, “Chemische Technologie” [Chemical Technology], Volume 7, 4th Ed., C. Hanser Verlag Munich 1986.

In a preferred embodiment, the plants or plant parts are treated according to the invention with an oil-based suspension concentrate. An advantageous suspension concentrate is known from WO 2005/084435 (EP 1 725 104 A2). It consists of at least one agrochemically active compound solid at room temperature, at least one “closed” penetrant, at least one vegetable oil or mineral oil, at least one non-ionic surfactant and/or at least one anionic surfactant and, if appropriate, one or more additives from the groups of the emulsifiers, the antifoams, the preservatives, the antioxidants, the colourants and/or the inert fillers. Preferred embodiments of the suspension concentrate are described in the abovementioned WO 2005/084435. Corresponding suspension concentrates on a vegetable oil basis are described in EP 1 725 105 A2 expressly for the 3-APD which can be used here according to the invention. For the purpose of disclosure, both documents are incorporated herein in their entirety.

In a further preferred embodiment, the plants or plant parts are treated according to the invention with compositions comprising ammonium or phosphonium salts and, if appropriate, penetrants. An advantageous composition is known from DE 05059469. It consists of at least one active compound from the class of the 3-APD and at least one ammonium or phosphonium salt, and if appropriate penetrants. Preferred embodiments are described in DE 05059469. For the purpose of disclosure, this document is incorporated herein in its entirety.

In general, the formulations comprise from 0.01 to 98% by weight of active compound, preferably from 0.5 to 90%. In wettable powders, the active compound concentration is, for example, from about 10 to 90% by weight, the remainder to 100% by weight consisting of customary formulation components. In the case of emulsifiable concentrates, the active compound concentration can be from about 5 to 80% by weight. In most cases, formulations in the form of dusts comprise from 5 to 20% by weight of active compound, sprayable solutions comprise about 2 to 20% by weight. In the case of granules, the active compound content depends partially on whether the active compound is present in liquid or solid form and on which granulation auxiliaries, fillers, etc., are used.

The required application rate may also vary with external conditions such as, inter alia, temperature and humidity. It may vary within wide limits, for example between 0.1 g/h and 5.0 kg/ha or more of active substance. However, it is preferably between 0.1 g/ha and 1.0 kg/ha. Owing to the synergistic effects between Bt vegetable and insecticide, particular preference is given to application rates of from 0.1 to 500 g/ha.

For compounds of the formula (I), preference is given to application rates of from 10 to 500 g/ha, particular preference is given to 10 to 200 g/ha.

In their commercial formulations and in the use forms prepared from these formulations, the active compounds according to the invention may be present as mixtures with other active compounds, such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, growth-regulating substances or herbicides.

Particularly favourable mixing partners are, for example, the following compounds:

Fungicides:

Inhibitors of nucleic acid synthesis

- benalaxyl, benalaxyl-M, bupirimate, chiralaxyl, clozylacon, dimethirimol, ethirimol, furalaxyl, hymexazol, metalaxyl, metalaxyl-M, ofurace, oxadixyl, oxolinic acid
  
  Inhibitors of mitosis and cell division
- benomyl, carbendazim, diethofencarb, fuberidazole, pencycuron, thiabendazole, thiophanat-methyl, zoxamide
  
  Inhibitors of respiratory chain complex I
- diflumetorim
  
  Inhibitors of respiratory chain complex II
- boscalid, carboxin, fenfuram, flutolanil, furametpyr, mepronil, oxycarboxin, penthiopyrad, thifluzamide
  
  Inhibitors of respiratory chain complex III
- azoxystrobin, cyazofamid, dimoxystrobin, enestrobin, famoxadone, fenamidone, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, pyraclostrobin, picoxystrobin, trifloxystrobin

Decouplers

- dinocap, fluazinam
  
  Inhibitors of ATP production
- fentin acetate, fentin chloride, fentin hydroxide, silthiofam
  
  Inhibitors of amino acid biosynthesis and protein biosynthesis
- andoprim, blasticidin-S, cyprodinil, kasugamycin, kasugamycin hydrochloride hydrate, mepanipyrim, pyrimethanil
  
  Inhibitors of signal transduction
- fenpiclonil, fludioxonil, quinoxyfen
  
  Inhibitors of lipid and membrane synthesis
- chlozolinate, iprodione, procymidone, vinclozolin
- ampropylfos, potassium-ampropylfos, edifenphos, iprobenfos (IBP), isoprothiolane, pyrazophos
- tolclofos-methyl, biphenyl
- iodocarb, propamocarb, propamocarb hydrochloride
  
  Inhibitors of ergosterol biosynthesis
- fenhexamid,
- azaconazole, bitertanol, bromuconazole, cyproconazole, diclobutrazole, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fenbuconazole, fluquinconazole, flusilazole, flutriafol, furconazole, furconazole-cis, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, paclobutrazole, penconazole, propiconazole, prothioconazole, simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triticonazole, uniconazole, voriconazole, imazalil, imazalil sulphate, oxpoconazole, fenarimol, flurprimidole, nuarimol, pyrifenox, triforine, pefurazoate, prochloraz, triflumizole, viniconazole,
- aldimorph, dodemorph, dodemorph acetate, fenpropimorph, tridemorph, fenpropidin, spiroxamine,
- naftifine, pyributicarb, terbinafine
  
  Inhibitors of cell wall synthesis
- benthiavalicarb, bialaphos, dimethomorph, flumorph, iprovalicarb, polyoxins, polyoxorim, validamycin A
  
  Inhibitors of melanin biosynthesis
- capropamid, diclocymet, fenoxanil, phthalid, pyroquilon, tricyclazole
- Resistance induction
- acibenzolar-S-methyl, probenazole, tiadinil
- Multisite
- captafol, captan, chlorothalonil, copper salts such as: copper hydroxide, copper naphthenate, copper oxychloride, copper sulphate, copper oxide, oxine-copper and Bordeaux mixture, dichlofluanid, dithianon, dodine, dodine free base, ferbam, folpet, fluorofolpet, guazatine, guazatine acetate, iminoctadine, iminoctadine albesilate, iminoctadine triacetate, mancopper, mancozeb, maneb, metiram, metiram zinc, propineb, sulphur and sulphur preparations containing calcium polysulphide, thiram, tolylfluanid, zineb, ziram
- Unknown mechanism
- amibromdol, benthiazol, bethoxazin, capsimycin, carvone, quinomethionate, chloropicrin, cufraneb, cyflufenamid, cymoxanil, dazomet, debacarb, diclomezine, dichlorophen, dicloran, difenzoquat, difenzoquat methyl sulphate, diphenylamine, ethaboxam, ferimzone, flumetover, flusulphamide, fluopicolide, fluoroimide, hexachlorobenzene, 8-hydroxy-quinoline sulphate, irumamycin, methasulphocarb, metrafenone, methyl isothiocyanate, mildiomycin, natamycin, nickel dimethyl dithiocarbamate, nitrothal-isopropyl, octhilinone, oxamocarb, oxyfenthiin, pentachlorophenol and salts, 2-phenylphenol and salts, piperalin, propanosine-sodium, proquinazid, pyrrol nitrin, quintozene, tecloftalam, tecnazene, triazoxide, trichlamide, zarilamid and 2,3,5,6-tetrachloro-4-(methylsulphonyl)pyridine, N-(4-chloro-2-nitrophenyl)-N-ethyl-4-methylbenzenesulphonamide, 2-amino-4-methyl-N-phenyl-5-thiazolecarboxamide, 2-chloro-N-(2,3-dihydro-1,1,3-trimethyl-1H-inden-4-yl)-3-pyridinecarboxamide, 3-[5-(4-chlorophenyl)-2,3-dimethylisoxazolidin-3-yl]pyridine, cis-1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol, 2,4-dihydro-5-methoxy-2-methyl-4-[[[[1-[3-(trifluoromethyl)phenyl]ethylidene]amino]oxy]methyl]phenyl]-3H-1,2,3-triazol-3-one (185336-79-2), methyl 1-(2,3-dihydro-2,2-dimethyl-1H-inden-1-yl)-1H-imidazole-5-carboxylate, 3,4,5-trichloro-2,6-pyridinedicarbonitrile, methyl 2-[[[cyclopropyl[(4-methoxyphenyl)imino]methyl]thio]methyl],alpha.-(methoxymethylene)benzacetate, 4-chloro-alpha-propynyloxy-N-[2-[3-methoxy-4-(2-propynyloxy)phenyl]ethyl]benz-acetamide, (2S)—N-[2-[4-[[3-(4-chlorophenyl)-2-propynyl]oxy]-3-methoxyphenyl]ethyl]-3-methyl-2-[(methylsulphonyl)amino]butanamide, 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine, 5-chloro-6-(2,4,6-trifluorophenyl)-N-[(1R)-1,2,2-trimethylpropyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, 5-chloro-N-[(1R)-1,2-dimethylpropyl]-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2,4-dichloronicotinamide, N-(5-bromo-3-chloro-pyridin-2-yl)methyl-2,4-dichloronicotinamide, 2-butoxy-6-iodo-3-propylbenzopyranon-4-one, N-{(Z)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]-methyl}-2-benzacetamide, N-(3-ethyl-3,5,5-trimethylcyclohexyl)-3-formylamino-2-hydroxybenzamide, 2-[[[[1-[3(1-fluoro-2-phenylethyl)oxy]phenyl]ethylidene]amino]oxy]-methyl]-alpha-(methoxyimino)-N-methyl-alphaE-benzacetamide, N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamide, N-(3′,4′-dichloro-5-fluorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, N-(6-methoxy-3-pyridinyl)cyclopropanecarboxamide, 1-[(4-methoxyphenoxy)methyl]-2,2-dimethylpropyl-1H-imidazole-1-carboxylic acid, O-[1-[4-methoxyphenoxy)methyl]-2,2-dimethylpropyl]-1H-imidazole-1-carbothioic acid, 2-(2-{[6-(3-chloro-2-methylphenoxy)-5-fluoropyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)-N-methylacetamide

Bactericides:

- bronopol, dichlorophen, nitrapyrin, nickel dimethyldithiocarbamate, kasugamycin, octhilinone, furancarboxylic acid, oxytetracycline, probenazole, streptomycin, tecloftalam, copper sulphate and other copper preparations.

Insecticides/acaricides/nematicides:

- Acetylcholine esterase (AChE) inhibitors
  - carbamates,
  - for example alanycarb, aldicarb, aldoxycarb, allyxycarb, aminocarb, bendiocarb, benfuracarb, bufencarb, butacarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulphan, cloethocarb, dimetilan, ethiofencarb, fenobucarb, fenothiocarb, formetanate, furathiocarb, isoprocarb, metam-sodium, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, promecarb, propoxur, thiodicarb, thiofanox, trimethacarb, XMC, xylylcarb, triazamate
  - organophosphates,
  - for example acephate, azamethiphos, azinphos (-methyl, -ethyl), bromophos-ethyl, bromfenvinfos (-methyl), butathiofos, cadusafos, carbophenothion, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos (-methyl, -ethyl), coumaphos, cyanofenphos, cyanophos, chlorfenvinphos, demeton-S-methyl, demeton-S-methylsulphone, dialifos, diazinon, dichlofenthion, dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos, dioxabenzofos, disulphoton, EPN, ethion, ethoprophos, etrimfos, famphur, fenamiphos, fenitrothion, fensulphothion, fenthion, flupyrazofos, fonofos, formothion, fosmethilan, fosthiazate, heptenophos, iodofenphos, iprobenfos, isazofos, isofenphos, isopropyl O-salicylate, isoxathion, malathion, mecarbam, methacrifos, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion (-methyl/-ethyl), phenthoate, phorate, phosalone, phosmet, phosphamidon, phosphocarb, phoxim, pirimiphos (-methyl/-ethyl), profenofos, propaphos, propetamphos, prothiofos, prothoate, pyraclofos, pyridaphenthion, pyridathion, quinalphos, sebufos, sulphotep, sulprofos, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, triclorfon, vamidothion
- Sodium channel modulators/voltage-dependent sodium channel blockers
  - pyrethroids,
  - for example acrinathrin, allethrin (d-cis-trans, d-trans), beta-cyfluthrin, bifenthrin, bioallethrin, bioallethrin-S-cyclopentyl isomer, bioethanomethrin, biopermethrin, bioresmethrin, chlovaporthrin, cis-cypermethrin, cis-resmethrin, cis-permethrin, clocythrin, cycloprothrin, cyfluthrin, cyhalothrin, cypermethrin (alpha-, beta-, theta-, zeta-), cyphenothrin, deltamethrin, empenthrin (1R isomer), esfenvalerate, etofenprox, fenfluthrin, fenpropathrin, fenpyrithrin, fenvalerate, flubrocythrinate, flucythrinate, flufenprox, flumethrin, fluvalinate, fubfenprox, gamma-cyhalothrin, imiprothrin, kadethrin, lambda-cyhalothrin, metofluthrin, permethrin (cis-, trans-), phenothrin (1R-trans-isomer), prallethrin, profluthrin, protrifenbute, pyresmethrin, resmethrin, RU 15525, silafluofen, tau-fluvalinate, tefluthrin, terallethrin, tetramethrin (1R isomer), tralomethrin, transfluthrin, ZXI 8901, pyrethrins (pyrethrum)
- DDT
  - oxadiazines,
  - for example indoxacarb
  - semicarbazones,
  - for example metaflumizone (BAS3201)
- Acetylcholine receptor agonists/antagonists
  - chloronicotinyls,
  - for example acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, nithiazine, thiacloprid, thiamethoxam
- nicotine, bensultap, cartap
- Acetylcholine receptor modulators
  - spinosyns,
  - for example spinosad,
- GABA-controlled chloride channel antagonists
  - organochlorines,
  - for example camphechlor, chlordane, endosulphan, gamma-HCH, HCH, heptachlor, lindane, methoxychlor
  - fiprols,
  - for example acetoprole, ethiprole, fipronil, pyrafluprole, pyriprole, vaniliprole
- Chloride channel activators
  - mectins,
  - for example abarmectin, emamectin, emamectin-benzoate, ivermectin, lepimectin, milbemycin
  - Juvenile hormone mimetics,
  - for example diofenolan, epofenonane, fenoxycarb, hydroprene, kinoprene, methoprene, pyriproxifen, triprene
- Ecdysone agonists/disruptors
  - diacylhydrazines,
  - for example chromafenozide, halofenozide, methoxyfenozide, tebufenozide
- Chitin biosynthesis inhibitors
  - benzoylureas,
  - for example bistrifluoron, chlofluazuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron, teflubenzuron, triflumuron
  - buprofezin
  - cyromazine
- Oxidative phosphorylation inhibitors, ATP disruptors
  - diafenthiuron
  - organotin compounds,
  - for example azocyclotin, cyhexatin, fenbutatin-oxide
- Oxidative phosphorylation decouplers acting by interrupting the H-proton gradient
  - pyrroles,
  - for example chlorfenapyr
  - dinitrophenols,
  - for example binapacyrl, dinobuton, dinocap, DNOC, meptyldinocap
- Site-I electron transport inhibitors
  - METIs,
  - for example fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad,
  - tolfenpyrad
  - hydramethylnon
  - dicofol
- Site-II electron transport inhibitors
  - rotenone
- Site-III electron transport inhibitors
  - acequinocyl, fluacrypyrim
- Microbial disruptors of the insect gut membrane
  - Bacillus thuringiensis strains
- Lipid synthesis inhibitors
  - tetronic acids,
  - for example spirodiclofen, spiromesifen
  - tetramic acids,
  - for example cis-3-(2,5-dimethylphenyl)-4-hydroxy-8-methoxy-1-azaspiro[4.5]-dec-3-en-2-one
  - carboxamides,
  - for example flonicamid
  - octopaminergic agonists,
  - for example amitraz
- Inhibitors of magnesium-stimulated ATPase,
  - propargite
  - nereistoxin analogues,
  - for example thiocyclam hydrogen oxalate, thiosultap-sodium
- Ryanodin receptor agonists
  - benzoic acid dicarboxamides,
  - for example flubendiamid
  - anthranilamides,
  - for example rynaxypyr (3-bromo-N-{4-chloro-2-methyl-6-[(methylamino)-carbonyl]phenyl}-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide)
- Biologicals, hormones or pheromones
  - azadirachtin, Bacillus spec., Beauveria spec., codlemone, Metarrhizium spec., Paecilomyces spec., thuringiensin, Verticillium spec.
- Active compounds with unknown or unspecific mechanisms of action
  - fumigants,
  - for example aluminium phosphide, methyl bromide, sulphuryl fluoride
  - antifeedants,
  - for example cryolite, flonicamid, pymetrozine
  - mite growth inhibitors,
  - for example clofentezine, etoxazole, hexythiazox amidoflumet, benclothiaz, benzoximate, bifenazate, bromopropylate, buprofezin, chinomethionat, chlordimeform, chlorobenzilate, chloropicrin, clothiazoben, cycloprene, cyflumetofen, dicyclanil, fenoxacrim, fentrifanil, flubenzimine, flu-fenerim, flutenzin, gossyplure, hydramethylnone, japonilure, metoxadiazone, petroleum, piperonyl butoxide, potassium oleate, pyridalyl, sulphluramid, tetra-difon, tetrasul, triarathene, verbutin

A mixture with other known active compounds, such as herbicides, fertilizers, growth regulators, safeners, semiochemicals, or else with agents for improving the plant properties, is also possible.

The active compound content of the use forms prepared from the commercially available formulations can be from 0.00000001 to 95% by weight, preferably between 0.00001 and 1% by weight, of active compound.

TABLE 1

Plant: Maize

Structure affected or principle expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolpyrimidines, pyrimidyloxybenzoates,

phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acid,

cyclohexanedione

hydroxyphenylpyruvate dioxygenase (HPPD)
isooxazoles, such as isoxaflutol or

isoxachlortol,

triones, such as mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles, such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazole, pyridine derivative,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1
xenobiotics and herbicides, such as

sulphonylurea

dimboa biosynthesis (Bx1-Gen)

Helminthosporium turcicum,

Rhopalosiphum maydis, Diplodia

maydis, Ostrinia nubilalis, Lepidoptera sp.

CMIII (small basic peptide building block
plant pathogens e.g. Fusarium, Alternaria,

from maize grain)
Sclerotina

Com-SAFP (zeamatin)
plant pathogens, e.g. Fusarium,

Alternaria, Sclerotina, Rhizoctonia,

Chaetomium, Phycomycen

Hm1-gene

Cochliobulus

chitinases
plant pathogens

glucanases
plant pathogens

envelope proteins
viruses, such as the Maize dwarf mosaic virus

(MDMV)

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, Coleoptera, Diptera,

Bacillus cereus toxin, Photorabdus and
nematodes, e.g. Ostrinia nubilalis,

Xenorhabdus toxins
Heliothis zea, armyworms e.g.

Spodoptera frugiperda, Western corn

rootworm, Sesamia sp., Aprotis ipsilon, Asian

corn borer, weevils

3-hydroxysteroid oxidase
Lepidoptera, Coleoptera, Diptera, nematodes,

e.g. Ostrinia nubilalis, Heliothis zea,

armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis

ipsilon,

Asian corn borer, weevils

peroxidase
Lepidoptera, Coleoptera, Diptera, nematodes,

e.g. Ostrinia nubilalis, Heliothis zea,

armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis

ipsilon, Asian corn borer, weevils

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, Coleoptera, Diptera,

aminopeptidase inhibitors (LAPI)
nematodes, e.g. Ostrinia nubilalis,

Heliothis zea, armyworms e.g. Spodoptera

frugiperda, Western corn rootworm, Sesamia

sp., Aprotis ipsilon, Asian corn borer, weevils

limonene synthase
Western corn rootworm

lectin
Lepidoptera, Coleoptera, Diptera, nematodes,

e.g. Ostrinia nubilalis, Heliothis zea,

armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis

ipsilon, Asian corn borer, weevils

protease inhibitors e.g. cystatin, patatin,
weevils, Western corn rootworm

virgiferin, CPTI

ribosome-inactivating protein
Lepidoptera, Coleoptera, Diptera, nematodes,

e.g. Ostrinia nubilalis, Heliothis zea,

armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis

ipsilon, Asian corn borer, weevils

5C9-maize polypeptide
Lepidoptera, Coleoptera, Diptera, nematodes,

e.g. Ostrinia nubilalis, Heliothis zea,

armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis

ipsilon, Asian corn borer, weevils

HMG-CoA reductase
Lepidoptera, Coleoptera, Diptera, nematodes,

e.g. Ostrinia nubilalis, Heliothis zea,

armyworms e.g. Spodoptera frugiperda,

Western corn rootworm, Sesamia sp., Aprotis

ipsilon, Asian corn borer, weevils

Plant: Wheat

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compods, imidazolinones

triazolpyrimidines, pyrimidyloxybenzoates,

phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acid,

cyclohexanedione

hydroxyphenylpyruvate dioxygenase (HPPD)
isooxazoles, such as isoxaflutol

or isoxachlortol,

triones, such as mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles, such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1
xenobiotics and herbicides, such as

sulphonylurea compounds

antifungal polypeptide AlyAFP
plant pathogens, e.g. Septoria and Fusarium

glucose oxidase
plant pathogens, e.g. Fusarium, Septoria

pyrrolnitrin synthesis gene
plant pathogens, e.g. Fusarium, Septoria

serine/threonine kinases
plant pathogens, e.g. Fusarium, Septoria

and other diseases

polypeptide having the effect of triggering
plant pathogens, e.g. Fusarium, Septoria and

a hypersensitivity reaction
other diseases

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

chitinases
plant pathogens

glucanases
plant pathogens

double-strand ribonuclease
viruses such as, for example, BYDV and

MSMV

envelope proteins
viruses such as, for example, BYDV and

MSMV

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, Coleoptera, Diptera,

Bacillus cereus toxins, Photorabdus and
nematodes

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, Coleoptera, Diptera,

nematodes

peroxidase
Lepidoptera, Coleoptera, Diptera,

nematodes

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, Coleoptera, Diptera,

aminopeptidase inhibitor
nematodes

lectins
Lepidoptera, Coleoptera, Diptera,

nematodes, aphids

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, Coleoptera, Diptera,

virgiferin, CPTI
nematodes, aphids

ribosome-inactivating protein
Lepidoptera, Coleoptera, Diptera,

nematodes, aphids

HMG-CoA reductase
Lepidoptera, Coleoptera, Diptera,

nematodes, e.g. Ostrinia nubilalis,

Heliothis zea, armyworms e.g. Spodoptera

frugiperda, Western corn rootworm, Sesamia

sp., Aprotis ipsilon, Asian corn borer, weevils

Plant: Barley

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolpyrimidines, pyrimidyloxybenzoates,

phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isooxazoles, such as isoxaflutol or

isoxachlortol,

triones, such as mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles, such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1
xenobiotics and herbicides, such as

sulphonylurea compounds

antifungal polypeptide AlyAFP
plant pathogens, e.g. Septoria and Fusarium

glucose oxidase
plant pathogens, e.g. Fusarium, Septoria

pyrrolnitrin synthesis gene
plant pathogens, e.g. Fusarium, Septoria

serine/threonine kinases
plant pathogens, e.g. Fusarium, Septoria

and other diseases

polypeptide having the effect of triggering
plant pathogens, e.g. Fusarium, Septoria and

a hypersensitivity reaction
other diseases

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

chitinases
plant pathogens

glucanases
plant pathogens

double-strand ribonuclease
viruses such as, for example, BYDV and

MSMV

envelope proteins
viruses such as, for example, BYDV and

MSMV

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, Coleoptera, Diptera,

Bacillus cereus toxins, Photorabdus and
nematodes

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, Coleoptera, Diptera,

nematodes

peroxidase
Lepidoptera, Coleoptera, Diptera,

nematodes

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, Coleoptera, Diptera,

aminopeptidase inhibitor
nematodes

lectins
Lepidoptera, Coleoptera, Diptera,

nematodes, aphids

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, Coleoptera, Diptera,

virgiferin, CPTI
nematodes, aphids

ribosome-inactivating protein
Lepidoptera, Coleoptera, Diptera,

nematodes, aphids

HMG-CoA reductase
Lepidoptera, Coleoptera, Diptera,

nematodes, aphids

Plant: Rice

Structure affected/principle expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolpyrimidines, pyrimidyloxybenzoates,

phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acid,

cyclohexanedione

hydroxyphenylpyruvate dioxygenase (HPPD)
isooxazoles, such as isoxaflutol or

isoxachlortol,

triones, such as mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles, such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1
xenobiotics and herbicides, such as

sulphonylurea compounds

antifungal polypeptide AlyAFP
plant pathogens

glucose oxidase
plant pathogens

pyrrolnitrin synthesis gene
plant pathogens

serine/threonine kinases
plant pathogens

phenylalanine ammonia lyase (PAL)
plant pathogens, e.g. bacterial

foliar mildew and inducible rice blast

phytoalexins
plant pathogens, e.g. bacterial

foliar mildew and rice blast

B-1,3-glucanase (antisense)
plant pathogens, e.g. bacterial

foliar mildew and rice blast

receptor kinase
plant pathogens, e.g. bacterial

foliar mildew and rice blast

polypeptide having the effect of triggering
plant pathogens

a hypersensitivity reaction

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

chitinases
plant pathogens, e.g. bacterial

foliar mildew and rice blast

glucanases
plant pathogens

double-strand ribonuclease
viruses such as, for example, BYDV and

MSMV

envelope proteins
viruses such as, for example, BYDV and

MSMV

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, e.g. stem borer, Coleoptera,

Bacillus cereus toxins, Photorabdus and
e.g. weevils such as Lissorhoptrus oryzophilus,

Xenorhabdus toxins
Diptera, rice planthoppers, e.g. rice brown

planthopper

3-hydroxysteroid oxidase
Lepidoptera, e.g. stem borer, Coleoptera,

e.g. weevils such as Lissorhoptrus oryzophilus,

Diptera, rice planthoppers, e.g. rice brown

planthopper

peroxidase
Lepidoptera, e.g. stem borer, Coleoptera,

e.g. weevils such as Lissorhoptrus oryzophilus,

Diptera, rice planthoppers, e.g. rice brown

planthopper

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, e.g. stem borer, Coleoptera,

aminopeptidase inhibitor
e.g. weevils such as Lissorhoptrus

oryzophilus, Diptera, rice planthoppers, e.g.

rice brown planthopper

lectins
Lepidoptera, e.g. stem borer, Coleoptera,

e.g. weevils such as Lissorhoptrus

oryzophilus, Diptera, rice planthoppers, e.g.

rice brown planthopper

protease inhibitors
Lepidoptera, e.g. stem borer, Coleoptera,

e.g. weevils such as Lissorhoptrus oryzophilus,

Diptera, rice planthoppers e.g. rice brown

planthopper

ribosome-inactivating protein
Lepidoptera, e.g. stem borer, Coleoptera,

e.g. weevils such as Lissorhoptrus

oryzophilus, Diptera, rice planthoppers, e.g.

rice brown planthopper

HMG-CoA reductase
Lepidoptera, e.g. stem borer, Coleoptera,

e.g. weevils such as Lissorhoptrus

oryzophilus, Diptera, rice planthoppers e.g.

rice brown planthopper

Plant: Soya bean

Structure affected/principle expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolpyrimidines, pyrimidyloxybenzoates,

phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isooxazoles, such as isoxaflutol or

isoxachlortol,

triones, such as mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles, such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphonate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides, such as

sulphonylurea compounds

antifungal polypeptide AlyAFP
bacterial and fungal pathogens such as, for

example, Fusarium, Sclerotinia, stem rot

oxalate oxidase
bacterial and fungal pathogens such as, for

example, Fusarium, Sclerotinia, stem rot

glucose oxidase
bacterial and fungal pathogens such as, for

example, Fusarium, Sclerotinia, stem rot

pyrrolnitrin synthesis gene
bacterial and fungal pathogens such as, for

example, Fusarium, Sclerotinia, stem rot

serine/threonine kinases
bacterial and fungal pathogens such as, for

example, Fusarium, Sclerotinia, stem rot

phenylalanine ammonia lyase (PAL)
bacterial and fungal pathogens such as, for

example, Fusarium, Sclerotinia, stem rot

phytoalexins
plant pathogens, e.g. bacterial foliar

mildew and rice blast

B-1,3-glucanase (antisense)
plant pathogens, e.g. bacterial foliar

mildew and rice blast

receptor kinase
bacterial and fungal pathogens such as, for

example, Fusarium, Sclerotinia, stem rot

polypeptide having the effect of triggering
plant pathogens

a hypersensitivity reaction

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

chitinases
bacterial and fungal pathogens such as, for

example, Fusarium, Sclerotinia, stem rot

glucanases
bacterial and fungal pathogens such as, for

example, Fusarium, Sclerotinia, stem rot

double-strand ribonuclease
viruses such as, for example, BPMV and

SbMV

envelope proteins
viruses such as, for example, BYDV and

MSMV

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, Coleoptera, aphids

Bacillus cereus toxins, Photorabdus and

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, Coleoptera, aphids

peroxidase
Lepidoptera, Coleoptera, aphids

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, Coleoptera, aphids

aminopeptidase inhibitor

lectins
Lepidoptera, Coleoptera, aphids

protease inhibitors, e.g. virgiferin
Lepidoptera, Coleoptera, aphids

ribosome-inactivating protein
Lepidoptera, Coleoptera, aphids

HMG-CoA reductase
Lepidoptera, Coleoptera, aphids

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

hatching factor for cyst nematodes
cyst nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

cyst nematodes

Plant: Potato

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolpyrimidines, pyrimidyloxybenzoates,

phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isooxazoles, such as isoxaflutol or

isoxachlortol,

triones, such as mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles, such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides, such as

sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
black spot

(antisense)

metallothionein
bacterial and fungal pathogens such as, for

example, Phytophtora,

ribonuclease
Phytophtora, Verticillium, Rhizoctonia

antifungal polypeptide AlyAFP
bacterial and fungal pathogens such as, for

example, Phytophtora

oxalate oxidase
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

glucose oxidase
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

pyrrolnitrin synthesis gene
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

serine/threonine kinases
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

cecropin B
bacteria such as, for example, Coryne-

bacterium sepedonicum, Erwinia carotovora

phenylalanine ammonia lyase (PAL)
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

phytoalexins
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

B-1,3-glucanase (antisense)
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

receptor kinase
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

polypeptide having the effect of triggering
bacterial and fungal pathogens such as, for

a hypersensitivity reaction
example, Phytophtora, Verticillium, Rhizoctonia

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

chitinases
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

barnase
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

gene 49 for controlling disease resistance
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

trans-aldolase (antisense)
black spot

glucanases
bacterial and fungal pathogens such as, for

example, Phytophtora, Verticillium, Rhizoctonia

double-strand ribonuclease
viruses such as, for example, PLRV, PVY and

TRV

envelope proteins
viruses such as, for example, PLRV, PVY and

TRV

17 kDa or 60 kDa protein
viruses such as, for example, PLRV, PVY and

TRV

nuclear inclusion proteins, e.g. a or b
viruses such as, for example, PLRV, PVY and

TRV

pseudoubiquitin
viruses such as, for example, PLRV, PVY and

TRV

replicase
viruses such as, for example, PLRV, PVY and

TRV

toxins of Bacillus thuringiensis, VIP 3,
Coleoptera, e.g. Colorado beetle, aphids

Bacillus cereus toxins, Photorabdus and

Xenorhabdus toxins

3-hydroxysteroid oxidase
Coleoptera, e.g. Colorado beetle, aphids

peroxidase
Coleoptera, e.g. Colorado beetle, aphids

aminopeptidase inhibitors, e.g. leucine
Coleoptera, e.g. Colorado beetle, aphids

aminopeptidase inhibitor

stilbene synthase
Coleoptera, e.g. Colorado beetle, aphids

lectins
Coleoptera, e.g. Colorado beetle, aphids

protease inhibitors, e.g. cystatin, patatin
Coleoptera, e.g. Colorado beetle, aphids

ribosomene-inactivating protein
Coleoptera, e.g. Colorado beetle, aphids

HMG-CoA reductase
Coleoptera, e.g. Colorado beetle, aphids

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

cyst nematodes

Plant: Tomato

Structure affected/principle expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolpyrimidines, pyrimidyloxybenzoates,

phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acid,

cyclohexanedione

hydroxyphenylpyruvate dioxygenase (HPPD)
isooxazoles, such as isoxaflutol or

isoxachlortol,

triones, such as mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles, such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

Cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides, such as

sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
black spot

(antisense)

metallothionein
bacterial and fungal pathogens such as, for

example, Phytophtora

ribonuclease
Phytophtora, Verticillium, Rhizoctonia

antifungal polypeptide AlyAFP
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

oxalate oxidase
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

glucose oxidase
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

pyrrolnitrin synthesis gene
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

serine/threonine kinases
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

cecropin B
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

phenylalanine ammonia lyase (PAL)
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
leaf mould

osmotin
early blight

alpha hordothionin
bakteria

systemin
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

polygalacturonase inhibitors
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

Prf control gene
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

12 fusarium resistance site

Fusarium

phytoalexins
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

B-1,3-glucanase (antisense)
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

receptor kinase
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

polypeptide having the effect of triggering
bacterial and fungal pathogens such as, for

a hypersensitivity reaction
example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

chitinases
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

barnase
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

glucanases
bacterial and fungal pathogens such as, for

example, bacterial blotch, Fusarium,

soft rot, powdery mildew, foliar blight,

leaf mould etc.

double-strand ribonuclease
viruses such as, for example, PLRV, PVY and

ToMoV

envelope proteins
viruses such as, for example, PLRV, PVY and

ToMoV

17 kDa or 60 kDa protein
viruses such as, for example, PLRV, PVY and

ToMoV

nuclear inclusion proteins e.g. a or b or
viruses such as, for example, PLRV, PVY and

ToMoV

nucleoprotein
TRV

pseudoubiquitin
viruses such as, for example, PLRV, PVY and

ToMoV

replicase
viruses such as, for example, PLRV, PVY and

ToMoV

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera e.g. Heliothis, whitefly

Bacilluscereus toxins, Photorabdus and
aphids

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera e.g. Heliothis, whitefly,

aphids

peroxidase
Lepidoptera e.g. Heliothis, whitefly,

aphids

aminopeptidase inhibitors, e.g. leucine
Lepidoptera e.g. Heliothis, whitefly,

aminopeptidase inhibitor
aphids

lectins
Lepidoptera e.g. Heliothis, whitefly,

aphids

protease inhibitors, e.g. cystatin, patatin
Lepidoptera e.g. Heliothis, whitefly,

aphids

ribosome-inactivating protein
Lepidoptera e.g. Heliothis, whitefly,

aphids

stilbene synthase
Lepidoptera e.g. Heliothis, whitefly,

aphids

HMG-CoA reductase
Lepidoptera e.g. Heliothis, whitefly,

aphids

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

cyst nematodes

Plant: Bell Pepper

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example, sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
bacterial and fungal pathogens

(antisense)

metallothionein
bacterial and fungal pathogens

ribonuclease
bacterial and fungal pathogens

antifungal polypeptid AlyAFP
bacterial and fungal pathogens

oxalate oxidase
bacterial and fungal pathogens

glucose oxidase
bacterial and fungal pathogens

pyrrolnitrin synthesis genes
bacterial and fungal pathogens

serine/threonine kinases
bacterial and fungal pathogens

cecropin B
bacterial and fungal pathogens, rot,

leaf mould, etc.

phenylalanine ammonia lyase (PAL)
bacterial and fungal pathogens

Cf genes, e.g. Cf 9 Ct5 Cf4 Cf2
bacterial and fungal pathogens

osmotin
bacterial and fungal pathogens

alpha hordothionine
bacterial and fungal pathogens

systemin
bacterial and fungal pathogens

polygalacturonase inhibitors
bacterial and fungal pathogens

Prf control gene
bacterial and fungal pathogens

12 Fusarium resistance site

Fusarium

phytoalexins
bacterial and fungal pathogens

B-1,3-glucanase (antisense)
bacterial and fungal pathogens

receptor kinase
bacterial and fungal pathogens

polypeptide having the effect of triggering
bacterial and fungal pathogens

a hypersensitivity reaction

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

chitinases
bacterial and fungal pathogens

barnase
bacterial and fungal pathogens

glucanases
bacterial and fungal pathogens

double-strand ribonuclease
viruses such as, for example, CMV, TEV

envelope proteins
viruses such as, for example, CMV, TEV

17 kDa or 60 kDa protein
viruses such as, for example, CMV, TEV

nuclear inclusion proteins e.g. a or b or
viruses such as, for example, CMV, TEV

nucleoprotein

pseudoubiquitin
viruses such as, for example, CMV, TEV

replicase
viruses such as, for example, CMV, TEV

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, whitefly, aphids

Bacilluscereus toxins, Photorabdus and

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, whitefly, aphids

peroxidase
Lepidoptera, whitefly, aphids

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, whitefly, aphids

aminopeptidase inhibitor

lectins
Lepidoptera, whitefly, aphids

protease inhibitors, e.g. cystatin, patatin
Lepidoptera, whitefly, aphids

ribosome-inactivating protein
Lepidoptera, whitefly, aphids

stilbene synthase
Lepidoptera, whitefly, aphids

HMG-CoA reductase
Lepidoptera, whitefly, aphids

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

cyst nematodes

Plant: Grapevines

Structure affected/principle expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example, sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
bacterial and fungal pathogens such as

(antisense)

Botrytis and powdery mildew

metallothionein
bacterial and fungal pathogens such as

Botrytis and powdery mildew

ribonuclease
bacterial and fungal pathogens such as

Botrytis and powdery mildew

antifungal polypeptide AlyAFP
bacterial and fungal pathogens such as

Botrytis and powdery mildew

oxalate oxidase
bacterial and fungal pathogens such as

Botrytis and powdery mildew

glucose oxidase
bacterial and fungal pathogens such as

Botrytis and powdery mildew

pyrrolnitrin synthesis genes
bacterial and fungal pathogens such as

Botrytis and powdery mildew

serine/threonine kinases
bacterial and fungal pathogens such as

Botrytis and powdery mildew

cecropin B
bacterial and fungal pathogens such as

Botrytis and powdery mildew

phenylalanine ammonia lyase (PAL)
bacterial and fungal pathogens such as

Botrytis and powdery mildew

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
bacterial and fungal pathogens such as

Botrytis and powdery mildew

osmotin
bacterial and fungal pathogens such as

Botrytis and powdery mildew

alpha hordothionine
bacterial and fungal pathogens such as

Botrytis and powdery mildew

systemin
bacterial and fungal pathogens such as

Botrytis and powdery mildew

polygalacturonase inhibitors
bacterial and fungal pathogens such as

Botrytis and powdery mildew

Prf control gene
bacterial and fungal pathogens such as

Botrytis and powdery mildew

phytoalexins
bacterial and fungal pathogens such as

Botrytis and powdery mildew

B-1,3-glucanase (antisense)
bacterial and fungal pathogens such as

Botrytis and powdery mildew

receptor kinase
bacterial and fungal pathogens such as

Botrytis and powdery mildew

polypeptide having the effect of triggering
bacterial and fungal pathogens such as Botrytis

a hypersensitivity reaction
and powdery mildew

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

chitinases
bacterial and fungal pathogens such as

Botrytis and powdery mildew

barnase
bacterial and fungal pathogens such as

Botrytis and powdery mildew

glucanases
bacterial and fungal pathogens such as Botrytis

and powdery mildew

double-strand ribonuclease
viruses

envelope proteins
viruses

17 kDa or 60 kDa protein
viruses

nuclear inclusion proteins e.g. a or b or
viruses

nucleoprotein

pseudoubiquitin
viruses

replicase
viruses

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, aphids

Bacilluscereus toxins, Photorabdus and

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, aphids

peroxidase
Lepidoptera, aphids

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, aphids

aminopeptidase inhibitor

lectins
Lepidoptera, aphids

protease inhibitors, e.g. cystatin, patatin
Lepidoptera, aphids

ribosome-inactivating protein
Lepidoptera, aphids

stilbene synthase
Lepidoptera, aphids, diseases

HMG-CoA reductase
Lepidoptera, aphids

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes or general diseases

CBI
root-knot nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes

or root-cyst nematodes

Plant: Oilseed rape

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example, sulphonylurea compounds

polyphenol oxidase or polyphenol
bacterial and fungal pathogens such as

oxidase (antisense)

Cylindrosporium, Phoma, Sclerotinia

metallothionein
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

ribonuclease
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

antifungal polypeptid AlyAFP
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

oxalate oxidase
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

glucose oxidase
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

pyrrolnitrin synthesis genes
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

serine/threonine kinases
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

cecropin B
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

phenylalanine ammonia lyase (PAL)
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

osmotin
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

alpha hordothionine
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

systemin
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

polygalacturonase inhibitors
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

Prf control gene
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

phytoalexins
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

B-1,3-glucanase (antisense)
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

receptor kinase
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

polypeptide having the effect of triggering
bacterial and fungal pathogens such as

a hypersensitivity reaction

Cylindrosporium, Phoma, Sclerotinia

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

chitinases
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

barnase
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia,

nematodes

glucanases
bacterial and fungal pathogens such as

Cylindrosporium, Phoma, Sclerotinia

double-strand ribonuclease
viruses

envelope proteins
viruses

17 kDa or 60 kDa protein
viruses

nuclear inclusion proteins e.g. a or b or
viruses

nucleoprotein

pseudoubiquitin
viruses

replicase
viruses

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, aphids

Bacilluscereus toxins, Photorabdus and

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, aphids

peroxidase
Lepidoptera, aphids

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, aphids

aminopeptidase inhibitor

lectins
Lepidoptera, aphids

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, aphids

CPTI

ribosome-inactivating protein
Lepidoptera, aphids

stilbene synthase
Lepidoptera, aphids, diseases

HMG-CoA reductase
Lepidoptera, aphids

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

CBI
root-knot nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

induced at nematode feeding sites
root-cyst nematodes

Plant: Brassica vegetables (cabbage, Brussels sprouts etc.)

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example, sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
bacterial and fungal pathogens

(antisense)

metallothionein
bacterial and fungal pathogens

ribonuclease
bacterial and fungal pathogens

antifungal polypeptid AlyAFP
bacterial and fungal pathogens

oxalate oxidase
bacterial and fungal pathogens

glucose oxidase
bacterial and fungal pathogens

pyrrolnitrin synthesis genes
bacterial and fungal pathogens

serine/threonine kinases
bacterial and fungal pathogens

cecropin B
bacterial and fungal pathogens

phenylalanine ammonia lyase (PAL)
bacterial and fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
bacterial and fungal pathogens

osmotin
bacterial and fungal pathogens

alpha hordothionine
bacterial and fungal pathogens

systemin
bacterial and fungal pathogens

polygalacturonase inhibitors
bacterial and fungal pathogens

Prf control gene
bacterial and fungal pathogens

phytoalexins
bacterial and fungal pathogens

B-1,3-glucanase (antisense)
bacterial and fungal pathogens

receptor kinase
bacterial and fungal pathogens

polypeptide having the effect of triggering
bacterial and fungal pathogens

a hypersensitivity reaction

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

chitinases
bacterial and fungal pathogens

barnase
bacterial and fungal pathogens

glucanases
bacterial and fungal pathogens

double-strand ribonuclease
viruses

envelope proteins
viruses

17 kDa or 60 kDa protein
viruses

nuclear inclusion proteins e.g. a or b or
viruses

nucleoprotein

pseudoubiquitin
viruses

replicase
viruses

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, aphids

Bacilluscereus toxins, Photorabdus and

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, aphids

peroxidase
Lepidoptera, aphids

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, aphids

aminopeptidase inhibitor

lectins
Lepidoptera, aphids

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, aphids

CPTI

ribosome-inactivating protein
Lepidoptera, aphids

stilbene synthase
Lepidoptera, aphids, diseases

HMG-CoA reductase
Lepidoptera, aphids

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

CBI
root-knot nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

induced at nematode feeding sites
root-cyst nematodes

cyst nematodes

Plants: Pomaceous fruit, e.g. apples, pears

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example, sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
bacterial and fungal pathogens such as

(antisense)
storage scab on apples or fire-blight

metallothionein
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

ribonuclease
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

antifungal polypeptid AlyAFP
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

oxalate oxidase
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

glucose oxidase
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

pyrrolnitrin synthesis genes
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

serine/threonine kinases
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

cecropin B
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

phenylalanine ammonia lyase (PAL)
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

osmotin
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

alpha hordothionine
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

systemin
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

polygalacturonase inhibitors
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

Prf control gene
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

phytoalexins
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

B-1,3-glucanase (antisense)
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

receptor kinase
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

polypeptide having the effect of triggering
bacterial and fungal pathogens such as

a hypersensitivity reaction
storage scab on apples or fire-blight

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

lytic protein
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

lysozyme
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

chitinases
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

barnase
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

glucanases
bacterial and fungal pathogens such as

storage scab on apples or fire-blight

double-strand ribonuclease
viruses

envelope proteins
viruses

17 kDa or 60 kDa protein
viruses

nuclear inclusion proteins e.g. a or b or
viruses

nucleoprotein

pseudoubiquitin
viruses

replicase
viruses

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, aphids, mites

Bacilluscereus toxins, Photorabdus and

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, aphids, mites

peroxidase
Lepidoptera, aphids, mites

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, aphids, mites

aminopeptidase inhibitor

lectins
Lepidoptera, aphids, mites

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, aphids, mites

CPTI

ribosome-inactivating protein
Lepidoptera, aphids, mites

stilbene synthase
Lepidoptera, aphids, diseases, mites

HMG-CoA reductase
Lepidoptera, aphids, mites

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

CBI
root-knot nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

induced at nematode feeding sites
root-cyst nematodes

Plant: Melon

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example, sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
bacterial or fungal pathogens such as

(antisense)
Phytophtora

metallothionein
bacterial or fungal pathogens such as

Phytophtora

ribonuclease
bacterial or fungal pathogens such as

Phytophtora

antifungal polypeptid AlyAFP
bacterial or fungal pathogens such as

Phytophtora

oxalate oxidase
bacterial or fungal pathogens such as

Phytophtora

glucose oxidase
bacterial or fungal pathogens such as

Phytophtora

pyrrolnitrin synthesis genes
bacterial or fungal pathogens such as

Phytophtora

serine/threonine kinases
bacterial or fungal pathogens such as

Phytophtora

cecropin B
bacterial or fungal pathogens such as

Phytophtora

phenylalanine ammonia lyase (PAL)
bacterial or fungal pathogens such as

Phytophtora

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
bacterial or fungal pathogens such as

Phytophtora

osmotin
bacterial or fungal pathogens such as

Phytophtora

alpha hordothionine
bacterial or fungal pathogens such as

Phytophtora

systemin
bacterial or fungal pathogens such as

Phytophtora

polygalacturonase inhibitors
bacterial or fungal pathogens such as

Phytophtora

Prf control gene
bacterial or fungal pathogens such as

Phytophtora

phytoalexins
bacterial or fungal pathogens such as

Phytophtora

B-1,3-glucanase (antisense)
bacterial or fungal pathogens such as

Phytophtora

receptor kinase
bacterial or fungal pathogens such as

Phytophtora

polypeptide having the effect of triggering
bacterial or fungal pathogens such as

a hypersensitivity reaction
Phytophtora

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

lytic protein
bacterial or fungal pathogens such as

Phytophtora

lysozyme
bacterial or fungal pathogens such as

Phytophtora

chitinases
bacterial or fungal pathogens such as

Phytophtora

barnase
bacterial or fungal pathogens such as

Phytophtora

glucanases
bacterial or fungal pathogens such as

Phytophtora

double-strand ribonuclease
viruses such as CMV, PRSV, WMV2, SMV,

ZYMV

envelope proteins
viruses such as CMV, PRSV, WMV2, SMV,

ZYMV

17 kDa or 60 kDa protein
viruses such as CMV, PRSV, WMV2, SMV,

ZYMV

nuclear inclusion proteins e.g. a or b or
viruses such as CMV, PRSV, WMV2, SMV,

nucleoprotein
ZYMV

pseudoubiquitin
viruses such as CMV, PRSV, WMV2, SMV,

ZYMV

replicase
viruses such as CMV, PRSV, WMV2, SMV,

ZYMV

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, aphids, mites

Bacilluscereus toxins, Photorabdus and

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, aphids, mites, whitefly

peroxidase
Lepidoptera, aphids, mites, whitefly

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, aphids, mites, whitefly

aminopeptidase inhibitor

lectins
Lepidoptera, aphids, mites, whitefly

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, aphids, mites, whitefly

CPTI, virgiferin

ribosome-inactivating protein
Lepidoptera, aphids, mites, whitefly

stilbene synthase
Lepidoptera, aphids, mites, whitefly

HMG-CoA reductase
Lepidoptera, aphids, mites, whitefly

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

CBI
root-knot nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

induced at nematode feeding sites
root-cyst nematodes

Plant: Banana

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example, sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
bacterial or fungal pathogens

(antisense)

metallothionein
bacterial or fungal pathogens

ribonuclease
bacterial or fungal pathogens

antifungal polypeptid AlyAFP
bacterial or fungal pathogens

oxalate oxidase
bacterial or fungal pathogens

glucose oxidase
bacterial or fungal pathogens

pyrrolnitrin synthesis genes
bacterial or fungal pathogens

serine/threonine kinases
bacterial or fungal pathogens

cecropin B
bacterial or fungal pathogens

phenylalanine ammonia lyase (PAL)
bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
bacterial or fungal pathogens

osmotin
bacterial or fungal pathogens

alpha hordothionine
bacterial or fungal pathogens

systemin
bacterial or fungal pathogens

polygalacturonase inhibitors
bacterial or fungal pathogens

Prf control gene
bacterial or fungal pathogens

phytoalexins
bacterial or fungal pathogens

B-1,3-glucanase (antisense)
bacterial or fungal pathogens

receptor kinase
bacterial or fungal pathogens

polypeptide having the effect of triggering
bacterial or fungal pathogens

a hypersensitivity reaction

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

lytic protein
bacterial or fungal pathogens

lysozyme
bacterial or fungal pathogens

chitinases
bacterial or fungal pathogens

barnase
bacterial or fungal pathogens

glucanases
bacterial or fungal pathogens

double-strand ribonuclease
viruses such as the Banana Bunchy Top Virus

(BBTV)

envelope proteins
viruses such as the Banana Bunchy Top Virus

(BBTV)

17 kDa or 60 kDa protein
viruses such as the Banana Bunchy Top Virus

(BBTV)

nuclear inclusion proteins e.g. a or b or
viruses such as the Banana Bunchy Top Virus

nucleoprotein
(BBTV)

pseudoubiquitin
viruses such as the Banana Bunchy Top Virus

(BBTV)

replicase
viruses such as the Banana Bunchy Top Virus

(BBTV)

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, aphids, mites, nematodes

Bacilluscereus toxins, Photorabdus and

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, aphids, mites, nematodes

peroxidase
Lepidoptera, aphids, mites, nematodes

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, aphids, mites, nematodes

aminopeptidase inhibitor

lectins
Lepidoptera, aphids, mites, nematodes

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, aphids, mites, nematodes

CPTI, virgiferin

ribosome-inactivating protein
Lepidoptera, aphids, mites, nematodes

stilbene synthase
Lepidoptera, aphids, mites, nematodes

HMG-CoA reductase
Lepidoptera, aphids, mites, nematodes

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

CBI
root-knot nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

induced at nematode feeding sites
root-cyst nematodes

Plant: Cotton

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthese

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example, sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
bacterial or fungal pathogens

(antisense)

metallothionein
bacterial or fungal pathogens

ribonuclease
bacterial or fungal pathogens

antifungal polypeptid AlyAFP
bacterial or fungal pathogens

oxalate oxidase
bacterial or fungal pathogens

glucose oxidase
bacterial or fungal pathogens

pyrrolnitrin synthesis genes
bacterial or fungal pathogens

serine/threonine kinases
bacterial or fungal pathogens

cecropin B
bacterial or fungal pathogens

phenylalanine ammonia lyase (PAL)
bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
bacterial or fungal pathogens

osmotin
bacterial or fungal pathogens

alpha hordothionine
bacterial or fungal pathogens

systemin
bacterial or fungal pathogens

polygalacturonase inhibitors
bacterial or fungal pathogens

Prf control gene
bacterial or fungal pathogens

phytoalexins
bacterial or fungal pathogens

B-1,3-glucanase (antisense)
bacterial or fungal pathogens

receptor kinase
bacterial or fungal pathogens

polypeptide having the effect of triggering
bacterial or fungal pathogens

a hypersensitivity reaction

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

lytic protein
bacterial or fungal pathogens

lysozyme
bacterial or fungal pathogens

chitinases
bacterial or fungal pathogens

barnase
bacterial or fungal pathogens

glucanases
bacterial or fungal pathogens

double-strand ribonuclease
viruses such as the wound tumour virus (WTV)

envelope proteins
viruses such as the wound tumour virus (WTV)

17 kDa or 60 kDa protein
viruses such as the wound tumour virus (WTV)

nuclear inclusion proteins e.g. a or b or
viruses such as the wound tumour virus (WTV)

nucleoprotein

pseudoubiquitin
viruses such as the wound tumour virus (WTV)

replicase
viruses such as the wound tumour virus (WTV)

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, aphids, mites, nematodes,

Bacilluscereus toxins, Photorabdus and
whitefly

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, aphids, mites, nematodes,

whitefly

peroxidase
Lepidoptera, aphids, mites, nematodes,

whitefly

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, aphids, mites, nematodes,

aminopeptidase inhibitor
whitefly

lectins
Lepidoptera, aphids, mites, nematodes,

whitefly

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, aphids, mites, nematodes,

CPTI, virgiferin
whitefly

ribosome-inactivating protein
Lepidoptera, aphids, mites, nematodes,

whitefly

stilbene synthase
Lepidoptera, aphids, mites, nematodes,

whitefly

HMG-CoA reductase
Lepidoptera, aphids, mites, nematodes,

whitefly

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

CBI
root-knot nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

induced at nematode feeding sites
root-cyst nematodes

Plant: Sugar cane

Feature affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example, sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
bacterial or fungal pathogens

(antisense)

metallothionein
bacterial or fungal pathogens

ribonuclease
bacterial or fungal pathogens

antifungal polypeptid AlyAFP
bacterial or fungal pathogens

oxalate oxidase
bacterial or fungal pathogens

glucose oxidase
bacterial or fungal pathogens

pyrrolnitrin synthesis genes
bacterial or fungal pathogens

serine/threonine kinases
bacterial or fungal pathogens

cecropin B
bacterial or fungal pathogens

phenylalanine ammonia lyase (PAL)
bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
bacterial or fungal pathogens

osmotin
bacterial or fungal pathogens

alpha hordothionine
bacterial or fungal pathogens

systemin
bacterial or fungal pathogens

polygalacturonase inhibitors
bacterial or fungal pathogens

Prf control gene
bacterial or fungal pathogens

phytoalexins
bacterial or fungal pathogens

B-1,3-glucanase (antisense)
bacterial or fungal pathogens

receptor kinase
bacterial or fungal pathogens

polypeptide having the effect of triggering
bacterial or fungal pathogens

a hypersensitivity reaction

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

lytic protein
bacterial or fungal pathogens

lysozyme
bacterial or fungal pathogens, e.g.

Clavibacter

chitinases
bacterial or fungal pathogens

barnase
bacterial or fungal pathogens

glucanases
bacterial or fungal pathogens

double-strand ribonuclease
viruses such as SCMV, SrMV

envelope proteins
viruses such as SCMV, SrMV

17 kDa or 60 kDa protein
viruses such as SCMV, SrMV

nuclear inclusion proteins e.g. a or b or
viruses such as SCMV, SrMV

nucleoprotein

pseudoubiquitin
viruses such as SCMV, SrMV

replicase
viruses such as SCMV, SrMV

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, aphids, mites, nematodes,

Bacilluscereus toxins, Photorabdus and
whitefly, beetles such as e.g. the Mexican

Xenorhabdus toxins
rice borer

3-hydroxysteroid oxidase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles such as e.g. the Mexican

rice borer

peroxidase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles such as e.g. the Mexican

rice borer

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, aphids, mites, nematodes,

aminopeptidase inhibitor
whitefly, beetles such as e.g. the Mexican

rice borer

lectins
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles such as e.g. the Mexican

rice borer

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, aphids, mites, nematodes,

CPTI, virgiferin
whitefly, beetles such as e.g. the Mexican

rice borer

ribosome-inactivating protein
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles such as e.g. the Mexican

rice borer

stilbene synthase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles such as e.g. the Mexican

rice borer

HMG-CoA reductase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles such as e.g. the Mexican

rice borer

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

CBI
root-knot nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

induced at nematode feeding sites
root-cyst nematodes

Plant: Sunflower

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example,

sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
bacterial or fungal pathogens

(antisense)

metallothionein
bacterial or fungal pathogens

ribonuclease
bacterial or fungal pathogens

antifungal polypeptid AlyAFP
bacterial or fungal pathogens

oxalate oxidase
bacterial or fungal pathogens, e.g.

Sclerotinia

glucose oxidase
bacterial or fungal pathogens

pyrrolnitrin synthesis genes
bacterial or fungal pathogens

serine/threonine kinases
bacterial or fungal pathogens

cecropin B
bacterial or fungal pathogens

phenylalanine ammonia lyase (PAL)
bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
bacterial or fungal pathogens

osmotin
bacterial or fungal pathogens

alpha hordothionine
bacterial or fungal pathogens

systemin
bacterial or fungal pathogens

polygalacturonase inhibitors
bacterial or fungal pathogens

Prf control gene
bacterial or fungal pathogens

phytoalexins
bacterial or fungal pathogens

B-1,3-glucanase (antisense)
bacterial or fungal pathogens

receptor kinase
bacterial or fungal pathogens

polypeptide having the effect of triggering
bacterial or fungal pathogens

a hypersensitivity reaction

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

lytic protein
bacterial or fungal pathogens

lysozyme
bacterial or fungal pathogens

chitinases
bacterial or fungal pathogens

barnase
bacterial or fungal pathogens

glucanases
bacterial or fungal pathogens

double-strand ribonuclease
viruses such as CMV, TMV

envelope proteins
viruses such as CMV, TMV

17 kDa or 60 kDa protein
viruses such as CMV, TMV

nuclear inclusion proteins e.g. a or b or
viruses such as CMV, TMV

nucleoprotein

pseudoubiquitin
viruses such as CMV, TMV

replicase
viruses such as CMV, TMV

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, aphids, mites, nematodes,

Bacilluscereus toxins, Photorabdus and
whitefly, beetles

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles

peroxidase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, aphids, mites, nematodes,

aminopeptidase inhibitor
whitefly, beetles

lectins
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, aphids, mites, nematodes,

CPTI, virgiferin
whitefly, beetles

ribosome-inactivating protein
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles

stilbene synthase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles

HMG-CoA reductase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

CBI
root-knot nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

induced at nematode feeding sites
root-cyst nematodes

Plants: Sugar beet, turnips

Structure affected/protein expressed
Feature of the plant/tolerance to

acetolactate synthase (ALS)
sulphonylurea compounds, imidazolinones

triazolopyrimidines,

pyrimidyloxybenzoates, phthalides

acetyl-CoA carboxylase (ACCase)
aryloxyphenoxyalkanecarboxylic acids,

cyclohexanediones

hydroxyphenylpyruvate dioxygenase (HPPD)
isoxazoles such as, for example, isoxaflutole or

isoxachlortole, triones such as, for example,

mesotrione or sulcotrione

phosphinothricin acetyltransferase
phosphinothricin

O-methyl transferase
modified lignin content

glutamine synthetase
glufosinate, bialaphos

adenylosuccinate lyase (ADSL)
inhibitors of IMP and AMP synthesis

adenylosuccinate synthase
inhibitors of adenylosuccinate synthesis

anthranilate synthase
inhibitors of tryptophan synthesis and

degradation

nitrilase
3,5-dihalo-4-hydroxybenzonitriles such as

bromoxynil and loxinyl

5-enolpyruvyl-3-phosphoshikimate
glyphosate or sulphosate

synthase (EPSPS)

glyphosate oxidoreductase
glyphosate or sulphosate

protoporphyrinogen oxidase (PROTOX)
diphenyl ethers, cyclic imides,

phenylpyrazoles, pyridine derivatives,

phenopylate, oxadiazoles etc.

cytochrome P450 e.g. P450 SU1 or selection
xenobiotics and herbicides such as, for

example, sulphonylurea compounds

polyphenol oxidase or polyphenol oxidase
bacterial or fungal pathogens

(antisense)

metallothionein
bacterial or fungal pathogens

ribonuclease
bacterial or fungal pathogens

antifungal polypeptid AlyAFP
bacterial or fungal pathogens

oxalate oxidase
bacterial or fungal pathogens, e.g.

Sclerotinia

glucose oxidase
bacterial or fungal pathogens

pyrrolnitrin synthesis genes
bacterial or fungal pathogens

serine/threonine kinases
bacterial or fungal pathogens

cecropin B
bacterial or fungal pathogens

phenylalanine ammonia lyase (PAL)
bacterial or fungal pathogens

Cf genes, e.g. Cf 9 Cf5 Cf4 Cf2
bacterial or fungal pathogens

osmotin
bacterial or fungal pathogens

alpha hordothionine
bacterial or fungal pathogens

systemin
Bakterielle or Pilz_pathogens

polygalacturonase inhibitors
bacterial or fungal pathogens

Prf control gene
bacterial or fungal pathogens

phytoalexins
bacterial or fungal pathogens

B-1,3-glucanase (antisense)
bacterial or fungal pathogens

AX + WIN-proteins
bacterial and fungal pathogens such as

Cercospora beticola

receptor kinase
bacterial or fungal pathogens

polypeptide having the effect of triggering
bacterial or fungal pathogens

a hypersensitivity reaction

systemic aquired resistance (SAR) genes
viral, bacterial, fungal and nematodal

pathogens

lytic protein
bacterial or fungal pathogens

lysozyme
bacterial or fungal pathogens

chitinases
bacterial or fungal pathogens

barnase
bacterial or fungal pathogens

glucanases
bacterial or fungal pathogens

double-strand ribonuclease
viruses such as, for example, BNYVV

envelope proteins
viruses such as, for example, BNYVV

17 kDa or 60 kDa protein
viruses such as, for example, BNYVV

nuclear inclusion proteins e.g. a or b or
viruses such as, for example, BNYVV

nucleoprotein

pseudoubiquitin
viruses such as, for example, BNYVV

replicase
viruses such as, for example, BNYVV

toxins of Bacillus thuringiensis, VIP 3,
Lepidoptera, aphids, mites, nematodes,

Bacilluscereus toxins, Photorabdus and
whitefly, beetles, root-flies

Xenorhabdus toxins

3-hydroxysteroid oxidase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles, root-flies

peroxidase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles, root-flies

aminopeptidase inhibitors, e.g. leucine
Lepidoptera, aphids, mites, nematodes,

aminopeptidase inhibitor
whitefly, beetles, root-flies

lectins
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles, root-flies

protease inhibitors, e.g. cystatin, patatin,
Lepidoptera, aphids, mites, nematodes,

CPTI, virgiferin
whitefly, beetles, root-flies

ribosome-inactivating protein
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles, root-flies

stilbene synthase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles, root-flies

HMG-CoA reductase
Lepidoptera, aphids, mites, nematodes,

whitefly, beetles, root-flies

hatching factor for cyst nematodes
cyst nematodes

barnase
nematodes, e.g. root-knot nematodes and

cyst nematodes

beet cyst nematode resistance site
cyst nematodes

CBI
root-knot nematodes

principles for preventing food uptake
nematodes, e.g. root-knot nematodes and

induced
root-cyst nematodes

TABLE 2

AP
Control of

CrylA(a)

Adoxophyes spp.

CrylA(a)

Agrotis spp.

CrylA(a)

Alabama argiliaceae

CrylA(a)

Anticarsia gemmatalis

CrylA(a)

Chilo spp.

CrylA(a)

Clysia ambiguella

CrylA(a)

Crocidolomia binotalis

CrylA(a)

Cydia spp.

CrylA(a)

Diparopsis castanea

CrylA(a)

Earias spp.

CrylA(a)

Ephestia spp.

CrylA(a)

Heliothis spp.

CrylA(a)

Hellula undalis

CrylA(a)

Keiferia lycopersicella

CrylA(a)

Leucoptera scitella

CrylA(a)

Lithocollethis spp.

CrylA(a)

Lobesia botrana

CrylA(a)

Ostrinia nubilalis

CrylA(a)

Pandemis spp.

CrylA(a)

Pectinophora gossyp.

CrylA(a)

Phyllocnistis citrella

CrylA(a)

Pieris spp.

CrylA(a)

Plutella xylostella

CrylA(a)

Scirpophaga spp.

CrylA(a)

Sesamia spp.

CrylA(a)

Sparganothis spp.

CrylA(a)

Spodoptera spp.

CrylA(a)

Tort-rix spp.

CrylA(a)

Trichoplusia ni

CrylA(a)

Agriotes spp.

CrylA(a)

Anthonomus grandis

CrylA(a)

Curculio spp.

CrylA(a)

Diabrotica balteata

CrylA(a)

Leptinotarsa spp.

CrylA(a)

Lissorhoptrus spp.

CrylA(a)

Otiorhynchus spp.

CrylA(a)

Aleurothrixus spp.

CrylA(a)

Aleyrodes spp.

CrylA(a)

Aonidiella spp.

CrylA(a)

Aphididea spp.

CrylA(a)

Aphis spp.

CrylA(a)

Bemisia tabaci

CrylA(a)

Empoasca spp.

CrylA(a)

Mycus spp.

CrylA(a)

Nephotettix spp.

CrylA(a)

Nilaparvata spp.

CrylA(a)

Pseudococcus spp.

CrylA(a)

Psylla spp.

CrylA(a)

Quadraspidiotus spp.

CrylA(a)

Schizaphis spp.

CrylA(a)

Trialeurodes spp.

CrylA(a)

Lyriomyza spp.

CrylA(a)

Oscinella spp.

CrylA(a)

Phorbia spp.

CrylA(a)

Frankliniella spp.

CrylA(a)

Thrips spp.

CrylA(a)

Scirtothrips aurantii

CrylA(a)

Aceria spp.

CrylA(a)

Aculus spp.

CrylA(a)

Brevipalpus spp.

CrylA(a)

Panonychus spp.

CrylA(a)

Phyllocoptruta spp.

CrylA(a)

Tetranychus spp.

CrylA(a)

Heterodera spp.

CrylA(a)

Meloidogyne spp.

CrylA(b)

Adoxophyes spp.

CrylA(b)

Agrotis spp.

CrylA(b)

Alabama argillaceae

CrylA(b)

Anticarsia gemmatalis

CrylA(b)

Chilo spp.

CrylA(b)

Clysia ambiguella

CrylA(b)

Crocidolomia binotalis

CrylA(b)

Cydia spp.

CrylA(b)

Diparopsis castanea

CrylA(b)

Earias spp.

CrylA(b)

Ephestia spp.

CrylA(b)

Heliothis spp.

CrylA(b)

Hellula undalis

CrylA(b)

Keiferia lycopersicella

CrylA(b)

Leucoptera scitella

CrylA(b)

Lithocollethis spp.

CrylA(b)

Lobesia botrana

CrylA(b)

Ostrinia nubilalis

CrylA(b)

Pandemis spp.

CrylA(b)

Pectinophora gossyp.

CrylA(b)

Phyllocnistis citrella

CrylA(b)

Pieris spp.

CrylA(b)

Plutelia xylostella

CrylA(b)

Scirpophaga spp.

CrylA(b)

Sesamia spp.

CrylA(b)

Sparganothis spp.

CrylA(b)

Spodoptera spp.

CrylA(b)

Tortrix spp.

CrylA(b)

Trichoplusia ni

CrylA(b)

Agriotes spp.

CrylA(b)

Anthonomus grandis

CrylA(b)

Curculio spp.

CrylA(b)

Diabrotica balteata

CrylA(b)

Leptinotarsa spp.

CrylA(b)

Lissorhoptrus spp.

CrylA(b)

Otiorhynchus spp.

CrylA(b)

Aleurothrixus spp.

CrylA(b)

Aleyrodes spp.

CrylA(b)

Aonidiella spp.

CrylA(b)

Aphididae spp.

CrylA(b)

Aphis spp.

CrylA(b)

Bemisia tabaci

CrylA(b)

Empoasca spp.

CrylA(b)

Mycus spp.

CrylA(b)

Nephotettix spp.

CrylA(b)

Nilaparvata spp.

CrylA(b)

Pseudococcus spp.

CrylA(b)

Psylla spp.

CrylA(b)

Quadraspidiotus spp.

CrylA(b)

Schizaphis spp.

CrylA(b)

Trialeurodes spp.

CrylA(b)

Lyriomyza spp.

CrylA(b)

Oscinella spp.

CrylA(b)

Phorbia spp.

CrylA(b)

Frankliniella spp.

CrylA(b)

Thrips spp.

CrylA(b)

Scirtothrips aurantii

CrylA(b)

Aceria spp.

CrylA(b)

Aculus spp.

CrylA(b)

Brevipalpus spp.

CrylA(b)

Panonychus spp.

CrylA(b)

Phyllocoptruta spp.

CrylA(b)

Tetranychus spp.

CrylA(b)

Heterodera spp.

CrylA(b)

Meloidogyne spp.

CrylA(c)

Adoxophyes spp.

CrylA(c)

Agrotis spp.

CrylA(c)

Alabama argillaceae

CrylA(c)

Anticarsia gemmatalis

CrylA(c)

Chilo spp.

CrylA(c)

Clysia ambiguella

CrylA(c)

Crocidolomia binotalis

CrylA(c)

Cydia spp.

CrylA(c)

Diparopsis castanea

CrylA(c)

Earias spp.

CrylA(c)

Ephestia spp.

CrylA(c)

Heliothis spp.

CrylA(c)

Hellula undalis

CrylA(c)

Keiferia lycopersicella

CrylA(c)

Leucoptera scitella

CrylA(c)

Lithocollethis spp.

CrylA(c)

Lobesia botrana

CrylA(c)

Ostrinia nubilalis

CrylA(c)

Pandemis spp.

CrylA(c)

Pectinophora gossypielia.

CrylA(c)

Phyllocnistis citrella

CrylA(c)

Pieris spp.

CrylA(c)

Plutella xylostella

CrylA(c)

Scirpophaga spp.

CrylA(c)

Sesamia spp.

CrylA(c)

Sparganothis spp.

CrylA(c)

Spodoptera spp.

CrylA(c)

Tortrix spp.

CrylA(c)

Trichoplusia ni

CrylA(c)

Agriotes spp.

CrylA(c)

Anthonomus grandis

CrylA(c)

Curculio spp.

CrylA(c)

Diabrotica balteata

CrylA(c)

Leptinotarsa spp.

CrylA(c)

Lissorhoptrus spp.

CrylA(c)

Otiorhynchus spp.

CrylA(c)

Aleurothrixus spp.

CrylA(c)

Aleyrodes spp.

CrylA(c)

Aonidiella spp.

CrylA(c)

Aphididae spp.

CrylA(c)

Aphis spp.

CrylA(c)

Bemisia tabaci

CrylA(c)

Empoasca spp.

CrylA(c)

Mycus spp.

CrylA(c)

Nephotettix spp.

CrylA(c)

Nilaparvata spp.

CrylA(c)

Pseudococcus spp.

CrylA(c)

Psylla spp.

CrylA(c)

Quadraspidiotus spp.

CrylA(c)

Schizaphis spp.

CrylA(c)

Trialeurodes spp.

CrylA(c)

Lyriomyza spp.

CrylA(c)

Oscinella spp.

CrylA(c)

Phorbia spp.

CrylA(c)

Frankliniella spp.

CrylA(c)

Thrips spp.

CrylA(c)

Scirtothrips aurantii

CrylA(c)

Aceria spp.

CrylA(c)

Aculus spp.

CrylA(c)

Brevipalpus spp.

CrylA(c)

Panonychus spp.

CrylA(c)

Phyllocoptruta spp.

CrylA(c)

Tetranychus spp.

CrylA(c)

Heterodera spp.

CrylA(c)

Meloidogyne spp.

CryllA

Adoxophyes spp.

CryllA

Agrotis spp.

CryllA

Alabama argillaceae

CryllA

Anticarsia gemmatalis

CryllA

Chilo spp.

CryllA

Clysia ambiguella

CryllA

Crocidolomia binotalis

CryllA

Cydia spp.

CryllA

Diparopsis castanea

CryllA

Earias spp.

CryllA

Ephestia spp.

CryllA

Heliothis spp.

CryllA

Hellula undalis

CryllA

Keiferia lycopersicella

CryllA

Leucoptera scitella

CryllA

Lithocoliethis spp.

CryllA

Lobesia botrana

CryllA

Ostrinia nubilalis

CryllA

Pandemis spp.

CryllA

Pectinophora gossyp.

CryllA

Phyllocnistis citrella

CryllA

Pieris spp.

CryllA

Plutella xylostella

CryllA

Scirpophaga spp.

CryllA

Sesamia spp.

CryllA

Sparganothis spp.

CryllA

Spodoptera spp.

CryllA

Tortrix spp.

CryllA

Trichoplusia ni

CryllA

Agriotes spp.

CryllA

Anthonomus grandis

CryllA

Curculio spp.

CryllA

Diabrotica balteata

CryllA

Leptinotarsa spp.

CryllA

Lissorhoptrus spp.

CryllA

Otiorhynchus spp.

CryllA

Aleurothrixus spp.

CryllA

Aleyrodes spp.

CryllA

Aonidiella spp.

CryllA

Aphididae spp.

CryllA

Aphis spp.

CryllA

Bemisia tabaci

CryllA

Empoasca spp.

CryllA

Mycus spp.

CryllA

Nephotettix spp.

CryllA

Nilaparvata spp.

CryllA

Pseudococcus spp.

CryllA

Psylla spp.

CryllA

Quadraspidiotus spp.

CryllA

Schizaphis spp.

CryllA

Trialeurodes spp.

CryllA

Lyriomyza spp.

CryllA

Oscinella spp.

CryllA

Phorbia spp.

CryllA

Frankliniella spp.

CryllA

Thrips spp.

CryllA

Scirtothrips aurantii

CryllA

Aceria spp.

CryllA

Acutus spp.

CryllA

Brevipalpus spp.

CryllA

Panonychus spp.

CryllA

Phyllocoptruta spp.

CryllA

Tetranychus spp.

CryllA

Heterodera spp.

CryllA

Meloidogyne spp.

CrylllA

Adoxophyes spp.

CrylllA

Agrotis spp.

CrylllA

Alabama argillaceae

CrylllA

Anticarsia gemmatalis

CrylllA

Chilo spp.

CrylllA

Clysia ambiguelia

CrylllA

Crocodolomia binotalis

CrylllA

Cydia spp.

CrylllA

Diparopsis castanea

CrylllA

Earias spp.

CrylllA

Ephestia spp.

CrylllA

Heliothis spp.

CrylllA

Hellula undalis

CrylllA

Keiferia lycopersicella

CrylllA

Leucoptera scitella

CrylllA

Lithocollethis spp.

CrylllA

Lobesia botrana

CrylllA

Ostrinia nubilalis

CrylllA

Pandemis spp.

CrylllA

Pectinophora gossyp.

CrylllA

Phyllocnistis citrella

CrylllA

Pieris spp.

CrylllA

Plutella xylostella

CrylllA

Scirpophaga spp.

CrylllA

Sesamia spp.

CrylllA

Sparganothis spp.

CrylllA

Spodoptera spp.

CrylllA

Tortrix spp.

CrylllA

Trichoplusia ni

CrylllA

Agriotes spp.

CrylllA

Anthonomus grandis

CrylllA

Curculio spp.

CrylllA

Diabrotica balteata

CrylllA

Leptinotarsa spp.

CrylllA

Lissorhoptrus spp.

CrylllA

Otiorhynchus spp.

CrylllA

Aleurothrixus spp.

CrylllA

Aleyrodes spp.

CrylllA

Aonidiella spp.

CrylllA

Aphididae spp.

CrylllA

Aphis spp.

CrylllA

Bemisia tabaci

CrylllA

Empoasca spp.

CrylllA

Mycus spp.

CrylllA

Nephotettix spp.

CrylllA

Nilaparvata spp.

CrylllA

Pseudococcus spp.

CrylllA

Psylla spp.

CrylllA

Quadraspidiotus spp.

CrylllA

Schizaphis spp.

CrylllA

Trialeurodes spp.

CrylllA

Lyriomyza spp.

CrylllA

Oscinella spp.

CrylllA

Phorbia spp.

CrylllA

Frankliniella spp.

CrylllA

Thrips spp.

CrylllA

Scirtothrips aurantii

CrylllA

Aceria spp.

CrylllA

Aculus spp.

CrylllA

Brevipalpus spp.

CrylllA

Panonychus spp.

CrylllA

Phyllocoptruta spp.

CrylllA

Tetranychus spp.

CrylllA

Heterodera spp.

CrylllA

Meloidogyne spp.

CrylllB2

Adoxophyes spp.

CrylllB2

Agrotis spp.

CrylllB2

Alabama argillaceae

CrylllB2

Anticarsia gemmatalis

CrylllB2

Chilo spp.

CrylllB2

Clysia ambiguella

CrylllB2

Crocidolomia binotalis

CrylllB2

Cydia spp.

CrylllB2

Diparopsis castanea

CrylllB2

Earias spp.

CrylllB2

Ephestia spp.

CrylllB2

Heliothis spp.

CrylllB2

Hellula undalis

CrylllB2

Keiferia lycopersicella

CrylllB2

Leucoptera scitella

CrylllB2

Lithocollethis spp.

CrylllB2

Lobesia botrana

CrylllB2

Ostrinia nubilalis

CrylllB2

Pandemis spp.

CrylllB2

Pectinophora gossyp.

CrylllB2

Phyllocnistis citrella

CrylllB2

Pieris spp.

CrylllB2

Plutella xylostella

CrylllB2

Scirpophaga spp.

CrylllB2

Sesamia spp.

CrylllB2

Sparganothis spp.

CrylllB2

Spodoptera spp.

CrylllB2

Tortrix spp.

CrylllB2

Trichoplusia ni

CrylllB2

Agriotes spp.

CrylllB2

Anthonomus grandis

CrylllB2

Curculio spp.

CrylllB2

Diabrotica balteata

CrylllB2

Leptinotarsa spp.

CrylllB2

Lissorhoptrus spp.

CrylllB2

Otiorhynchus spp.

CrylllB2

Aleurothrixus spp.

CrylllB2

Aleyrodes spp.

CrylllB2

Aonidiella spp.

CrylllB2

Aphididae spp.

CrylllB2

Aphis spp.

CrylllB2

Bemisia tabaci

CrylllB2

Empoasca spp.

CrylllB2

Mycus spp.

CrylllB2

Nephotettix spp.

CrylllB2

Nilaparvata spp.

CrylllB2

Pseudococcus spp.

CrylllB2

Psylla spp.

CrylllB2

Quadraspidiotus spp.

CrylllB2

Schizaphis spp.

CrylllB2

Trialeurodes spp.

CrylllB2

Lyriornyza spp.

CrylllB2

Oscinella spp.

CrylllB2

Phorbia spp.

CrylllB2

Frankliniella spp.

CrylllB2

Thrips spp.

CrylllB2

Scirtothrips aurantii

CrylllB2

Aceria spp.

CrylllB2

Acutus spp.

CrylllB2

Brevipalpus spp.

CrylllB2

Panonychus spp.

CrylllB2

Phyllocoptruta spp.

CrylllB2

Tetranychus spp.

CrylllB2

Heterodera spp.

CrylllB2

Meloidogyne spp.

CytA

Adoxophyes spp.

CytA

Agrotis spp.

CytA

Alabama argillaceae

CytA

Anticarsia gemmatalis

CytA

Chilo spp.

CytA

Clysia ambiguella

CytA

Crocidolomia binotalis

CytA

Cydia spp.

CytA

Diparopsis castanea

CytA

Earias spp.

CytA

Ephestia spp.

CytA

Heliothis spp.

CytA

Hellula undalis

CytA

Keiferia lycopersicella

CytA

Leucoptera scitella

CytA

Lithocollethis spp.

CytA

Lobesia botrana

CytA

Ostrinia nubilalis

CytA

Pandemis spp.

CytA

Pectinophora gossyp.

CytA

Phyllocnistis citrella

CytA

Pieris spp.

CytA

Plutella xylostella

CytA

Scirpophaga spp.

CytA

Sesamia spp.

CytA

Sparganothis spp.

CytA

Spodoptera spp.

CytA

Tortrix spp.

CytA

Trichoplusia ni

CytA

Agriotes spp.

CytA

Anthonomus grandis

CytA

Curculio spp.

CytA

Diabrotica balteata

CytA

Leptinotarsa spp.

CytA

Lissorhoptrus spp.

CytA

Otiorhynchus spp.

CytA

Aleurothrixus spp.

CytA

Aleyrodes spp.

CytA

Aonidiella spp.

CytA

Aphididae spp.

CytA

Aphis spp.

CytA

Bemisia tabaci

CytA

Empoasca spp.

CytA

Mycus spp.

CytA

Nephotettix spp.

CytA

Nilaparvata spp.

CytA

Pseudococcus spp.

CytA

Psylla spp.

CytA

Quadraspidiotus spp.

CytA

Schizaphis spp.

CytA

Trialeurodes spp.

CytA

Lyriomyza spp.

CytA

Oscinella spp.

CytA

Phorbia spp.

CytA

Frankliniella spp.

CytA

Thrips spp.

CytA

Scirtothrips aurantii

CytA

Aceria spp.

CytA

Acutus spp.

CytA

Brevipalpus spp.

CytA

Panonychus spp.

CytA

Phyllocoptruta spp.

CytA

Tetranychus spp.

CytA

Heterodera spp.

CytA

Meloidogyne spp.

VIP3

Adoxophyes spp.

VIP3

Agrotis spp.

VIP3

Alabama argillaceae

VIP3

Anticarsia gemmatalis

VIP3

Chilo spp.

VIP3

Clysia ambiguella

VIP3

Crocidolomia binotalis

VIP3

Cydia spp.

VIP3

Diparopsis castanea

VIP3

Earias spp.

VIP3

Ephestia spp.

VIP3

Heliothis spp.

VIP3

Hellula undalis

VIP3

Keiferia

lycopersicella

VIP3

Leucoptera scitella

VIP3

Lithocollethis spp.

VIP3

Lobesia botrana

VIP3

Ostrinia nubilalis

VIP3

Pandemis spp.

VIP3

Pectinophora gossyp.

VIP3

Phyllocnistis citrella

VIP3

Pieris spp.

VIP3

Plutella xylostella

VIP3

Scirpophaga spp.

VIP3

Sesamia spp.

VIP3

Sparganothis spp.

VIP3

Spodoptera spp.

VIP3

Tortrix spp.

VIP3

Trichoplusia ni

VIP3

Agriotes spp.

VIP3

Anthonomus grandis

VIP3

Curculio spp.

VIP3

Diabrotica balteata

VIP3

Leptinotarsa spp.

VIP3

Lissorhoptrus spp.

VIP3

Otiorhynchus spp.

VIP3

Aleurothrixus spp.

VIP3

Aleyrodes spp.

VIP3

Aonidiella spp.

VIP3

Aphididae spp.

VIP3

Aphis spp.

VIP3

Bemisia tabaci

VIP3

Empoasca spp.

VIP3

Mycus spp.

VIP3

Nephotettix spp.

VIP3

Nilaparvata spp.

VIP3

Pseudococcus spp.

VIP3

Psylla spp.

VIP3

Quadraspidiotus spp.

VIP3

Schizaphis spp.

VIP3

Trialeurodes spp.

VIP3

Lyriomyza spp.

VIP3

Oscinella spp.

VIP3

Phorbia spp.

VIP3

Frankliniella spp.

VIP3

Thrips spp.

VIP3

Scirtothrips aurantii

VIP3

Aceria spp.

VIP3

Acutus spp.

VIP3

Brevipalpus spp.

VIP3

Panonychus spp.

VIP3

Phyllocoptruta spp.

VIP3

Tetranychus spp.

VIP3

Heterodera spp.

VIP3

Meloidogyne spp.

GL

Adoxophyes spp.

GL

Agrotis spp.

GL

Alabama argillaceae

GL

Anticarsia gemmatalis

GL

Chilo spp.

GL

Clysia ambiguella

GL

Crocidolomia binotalis

GL

Cydia spp.

GL

Diparopsis castanea

GL

Earias spp.

GL

Ephestia spp.

GL

Heliothis spp.

GL

Hellula undalis

GL

Keiferia lycopersicella

GL

Leucoptera scitella

GL

Lithocollethis spp.

GL

Lobesia botrana

GL

Ostrinia nubilalis

GL

Pandemis spp.

GL

Pectinophora gossyp.

GL

Phyliocnistis citrella

GL

Pieris spp.

GL

Plutella xylostella

GL

Scirpophaga spp.

GL

Sesamia spp.

GL

Sparganothis spp.

GL

Spodoptera spp.

GL

Tortrix spp.

GL

Trichoplusia ni

GL

Agriotes spp.

GL

Anthonomus grandis

GL

Curculio spp.

GL

Diabrotica balteata

GL

Leptinotarsa spp.

GL

Lissorhoptrus spp.

GL

Otiorhynchus spp.

GL

Aleurothrixus spp.

GL

Aleyrodes spp.

GL

Aonidiella spp.

GL

Aphididae spp.

GL

Aphis spp.

GL

Bemisia tabaci

GL

Empoasca spp.

GL

Mycus spp.

GL

Nephotettix spp.

GL

Nilaparvata spp.

GL

Pseudococcus spp.

GL

Psylia spp.

GL

Quadraspidiotus spp.

GL

Schizaphis spp.

GL

Trialeurodes spp.

GL

Lyriomyza spp.

GL

Oscinella spp.

GL

Phorbia spp.

GL

Frankliniella spp.

GL

Thrips spp.

GL

Scirtothrips aurantii

GL

Aceria spp.

GL

Aculus spp.

GL

Brevipalpus spp.

GL

Panonychus spp.

GL

Phyliocoptruta spp.

GL

Tetranychus spp.

GL

Heterodera spp.

GL

Meloidogyne spp.

PL

Adoxophyes spp.

PL

Agrotis spp.

PL

Alabama argillaceae

PL

Anticarsia gemmatalis

PL

Chilo spp.

PL

Clysia ambiguella

PL

Crocidolomia binotalis

PL

Cydia spp.

PL

Diparopsis castanea

PL

Earias spp.

PL

Ephestia spp.

PL

Heliothis spp.

PL

Hellula undalis

PL

Keiferia lycopersicella

PL

Leucoptera scitella

PL

Lithocollethis spp.

PL

Lobesia botrana

PL

Ostrinia nubilalis

PL

Pandemis spp.

PL

Pectinophora gossyp.

PL

Phyllocnistis citrella

PL

Pieris spp.

PL

Plutella xylostella

PL

Scirpophaga spp.

PL

Sesamia spp.

PL

Sparganothis spp.

PL

Spodoptera spp.

PL

Tortrix spp.

PL

Trichoplusia ni

PL

Agriotes spp.

PL

Anthonomus grandis

PL

Curculio spp.

PL

Diabrotica balteata

PL

Leptinotarsa spp.

PL

Lissorhoptrus spp.

PL

Otiorhynchus spp.

PL

Aleurothrixus spp.

PL

Aleyrodes spp.

PL

Aonidiella spp.

PL

Aphididae spp.

PL

Aphis spp.

PL

Bemisia tabaci

PL

Empoasca spp.

PL

Mycus spp.

PL

Nephotettix spp.

PL

Nilaparvata spp.

PL

Pseudococcus spp.

PL

Psylla spp.

PL

Quadraspidiotus spp.

PL

Schizaphis spp.

PL

Trialeurodes spp.

PL

Lyriomyza spp.

PL

Oscinella spp.

PL

Phorbia spp.

PL

Frankliniella spp.

PL

Thrips spp.

PL

Scirtothrips aurantii

PL

Aceria spp.

PL

Aculus spp.

PL

Brevipalpus spp.

PL

Panonychus spp.

PL

Phyllocoptruta spp.

PL

Tetranychus spp.

PL

Heterodera spp.

PL

Meloidogyne spp.

XN

Adoxophyes spp.

XN

Agrotis spp.

XN

Alabama argillaceae

XN

Anticarsia gemmatalis

XN

Chilo spp.

XN

Clysia ambiguella

XN

Crocidolomia binotalis

XN

Cydia spp.

XN

Diparopsis castanea

XN

Earias spp.

XN

Ephestia spp.

XN

Heliothis spp.

XN

Hellula undalis

XN

Keiferia lycopersicella

XN

Leucoptera scitella

XN

Lithocollethis spp.

XN

Lobesia botrana

XN

Ostrinia nubilalis

XN

Pandemis spp.

XN

Pectinophora gossyp.

XN

Phyllocnistis citrella

XN

Pieris spp.

XN

Plutella xylostella

XN

Scirpophaga spp.

XN

Sesamia spp.

XN

Sparganothis spp.

XN

Spodoptera spp.

XN

Tortrix spp.

XN

Trichoplusia ni

XN

Agriotes spp.

XN

Anthonomus grandis

XN

Curculio spp.

XN

Diabrotica balteata

XN

Leptinotarsa spp.

XN

Lissorhoptrus spp.

XN

Otiorhynchus spp.

XN

Aleurothrixus spp.

XN

Aleyrodes spp.

XN

Aonidiella spp.

XN

Aphididae spp.

XN

Aphis spp.

XN

Bemisia tabaci

XN

Empoasca spp.

XN

Mycus spp.

XN

Nephotettix spp.

XN

Nilaparvata spp.

XN

Pseudococcus spp.

XN

Psylla spp.

XN

Quadraspidiotus spp.

XN

Schizaphis spp.

XN

Trialeurodes spp.

XN

Lyriomyza spp.

XN

Oscinella spp.

XN

Phorbia spp.

XN

Frankliniella spp.

XN

Thrips spp.

XN

Scirtothrips aurantii

XN

Aceria spp.

XN

Aculus spp.

XN

Brevipalpus spp.

XN

Panonychus spp.

XN

Phyllocoptruta spp.

XN

Tetranychus spp.

XN

Heterodera spp.

XN

Meloidogyne spp.

Plnh.

Adoxophyes spp.

Plnh.

Agrotis spp.

Plnh.

Alabama argillaceae

Plnh.

Anticarsia gemmatalis

Plnh.

Chilo spp.

Plnh.

Clysia ambiguella

Plnh.

Crocidolomia

binotalis

Plnh.

Cydia spp.

Plnh.

Diparopsis castanea

Plnh.

Earias spp.

Plnh.

Ephestia spp.

Plnh.

Heliothis spp.

Plnh.

Hellula undalis

Plnh.

Keiferia lycopersicella

Plnh.

Leucoptera scitella

Plnh.

Lithocollethis spp.

Plnh.

Lobesia botrana

Plnh.

Ostrinia nubilalis

Plnh.

Pandemis spp.

Plnh.

Pectinophora gossyp.

Plnh.

Phyllocnistis citrelia

Plnh.

Pieris spp.

Plnh.

Plutella xylostella

Plnh.

Scirpophaga spp.

Plnh.

Sesamia spp.

Plnh.

Sparganothis spp.

Plnh.

Spodoptera spp.

Plnh.

Tortrix spp.

Plnh.

Trichoplusia ni

Plnh.

Agriotes spp.

Plnh.

Anthonomus grandis

Plnh.

Curculio spp.

Plnh.

Diabrotica balteata

Plnh.

Leptinotarsa spp.

Plnh.

Lissorhoptrus spp.

Plnh.

Otiorhynchus spp.

Plnh.

Aleurothrixus spp.

Plnh.

Aleyrodes spp.

Plnh.

Aonidiella spp.

Plnh.

Aphididae spp.

Plnh.

Aphis spp.

Plnh.

Bemisia tabaci

Plnh.

Empoasca spp.

Plnh.

Mycus spp.

Plnh.

Nephotettix spp.

Plnh.

Nilaparvata spp.

Plnh.

Pseudococcus spp.

Plnh.

Psylla spp.

Plnh.

Quadraspidiotus spp.

Plnh.

Schizaphis spp.

Plnh.

Trialeurodes spp.

Plnh.

Lyriomyza spp.

Plnh.

Oscinella spp.

Plnh.

Phorbia spp.

Plnh.

Frankliniella spp.

Plnh.

Thrips spp.

Plnh.

Scirtothrips aurantii

Plnh.

Aceria spp.

Plnh.

Acutus spp.

Plnh.

Brevipalpus spp.

Plnh.

Panonychus spp.

Plnh.

Phyllocoptruta spp.

Plnh.

Tetranychus spp.

Plnh.

Heterodera spp.

Plnh.

Meloidogyne spp.

PLec.

Adoxophyes spp.

PLec.

Agrotis spp.

PLec.

Alabama argillaceae

PLec.

Anticarsia gemmatalis

PLec.

Chilo spp.

PLec.

Clysia ambiguella

PLec.

Crocidolomia binotalis

PLec.

Cydia spp.

PLec.

Diparopsis castanea

PLec.

Earias spp.

PLec.

Ephestia spp.

PLec.

Heliothis spp.

PLec.

Hellula undalis

PLec.

Keiferia lycopersicella

PLec.

Leucoptera scitella

PLec.

Lithocollethis spp.

PLec.

Lobesia botrana

PLec.

Ostrinia nubilalis

PLec.

Pandemis spp.

PLec.

Pectinophora gossyp.

PLec.

Phyllocnistis citrella

PLec.

Pieris spp.

PLec.

Plutella xylostella

PLec.

Scirpophaga spp.

PLec.

Sesamia spp.

PLec.

Sparganothis spp.

PLec.

Spodoptera spp.

PLec.

Tortrix spp.

PLec.

Trichoplusia ni

PLec.

Agriotes spp.

PLec.

Anthonomus grandis

PLec.

Curculio spp.

PLec.

Diabrotica balteata

PLec.

Leptinotarsa spp.

PLec.

Lissorhoptrus spp.

PLec.

Otiorhynchus spp.

PLec.

Aleurothrixus spp.

PLec.

Aleyrodes spp.

PLec.

Aonidiella spp.

PLec.

Aphididae spp.

PLec.

Aphis spp.

PLec.

Bemisia tabaci

PLec.

Empoasca spp.

PLec.

Mycus spp.

PLec.

Nephotettix spp.

PLec.

Nilaparvata spp.

PLec.

Pseudococcus spp.

PLec.

Psylla spp.

PLec.

Quadraspidiotus spp.

PLec.

Schizaphis spp.

PLec.

Trialeurodes spp.

PLec.

Lyriomyza spp.

PLec.

Oscinella spp.

PLec.

Phorbia spp.

PLec.

Frankliniella spp.

PLec.

Thrips spp.

PLec.

Scirtothrips aurantii

PLec.

Aceria spp.

PLec.

Aculus spp.

PLec.

Brevipalpus spp.

PLec.

Panonychus spp.

PLec.

Phyllocoptruta spp.

PLec.

Tetranychus spp.

PLec.

Heterodera spp.

PLec.

Meloidogyne spp.

Aggl.

Adoxophyes spp.

Aggl.

Agrotis spp.

Aggl.

Alabama

argillaceae

Aggl.

Anticarsia gemmatalis

Aggl.

Chilo spp.

Aggl.

Clysia ambiguella

Aggl.

Crocidolomia

binotalis

Aggl.

Cydia spp.

Aggl.

Diparopsis

castanea

Aggl.

Earias spp.

Aggl.

Ephestia spp.

Aggl.

Heliothis spp.

Aggl.

Hellula undalis

Aggl.

Keiferia

lycopersicella

Aggl.

Leucoptera scitella

Aggl.

Lithocollethis spp.

Aggl.

Lobesia botrana

Aggl.

Ostrinia nubilalis

Aggl.

Pandemis spp.

Aggl.

Pectinophora

gossyp.

Aggl.

Phyllocnistis citrella

Aggl.

Pieris spp.

Aggl.

Plutella xylostella

Aggl.

Scirpophaga spp.

Aggl.

Sesamia spp.

Aggl.

Sparganothis spp.

Aggl.

Spodoptera spp.

Aggl.

Tortrix spp.

Aggl.

Trichoplusia ni

Aggl.

Agriotes spp.

Aggl.

Anthonomus grandis

Aggl.

Curculio spp.

Aggl.

Diabrotica balteata

Aggl.

Leptinotarsa spp.

Aggl.

Lissorhoptrus spp.

Aggl.

Otiorhynchus spp.

Aggl.

Aleurothrixus spp.

Aggl.

Aleyrodes spp.

Aggl.

Aonidiella spp.

Aggl.

Aphididae spp.

Aggl.

Aphis spp.

Aggl.

Bemisia tabaci

Aggl.

Empoasca spp.

Aggl.

Mycus spp.

Aggl.

Nephotettix spp.

Aggl.

Nilaparvata spp.

Aggl.

Pseudococcus spp.

Aggl.

Psylla spp.

Aggl.

Quadraspidiotus spp.

Aggl.

Schizaphis spp.

Aggl.

Trialeurodes spp.

Aggl.

Lyriomyza spp.

Aggl.

Oscinella spp.

Aggl.

Phorbia spp.

Aggl.

Frankliniella spp.

Aggl.

Thrips spp.

Aggl.

Scirtothrips aurantii

Aggl.

Aceria spp.

Aggl.

Aculus spp.

Aggl.

Brevipalpus spp.

Aggl.

Panonychus spp.

Aggl.

Phyllocoptruta spp

Aggl.

Tetranychus spp.

Aggl.

Heterodera spp.

Aggl.

Meloidogyne spp.

CO

Adoxophyes spp.

CO

Agrotis spp.

CO

Alabama argillaceae

CO

Anticarsia gemmatalis

CO

Chilo spp.

CO

Clysia ambiguella

CO

Crocidolomia binotalis

CO

Cydia spp.

CO

Diparopsis castanea

CO

Earias spp.

CO

Ephestia spp.

CO

Heliothis spp.

CO

Hellula undalis

CO

Keiferia lycopersicella

CO

Leucoptera scitella

CO

Lithocollethis spp.

CO

Lobesia botrana

CO

Ostrinia nubilalis

CO

Pandemis spp.

CO

Pectinophora gossyp.

CO

Phyllocnistis citrella

CO

Pieris spp.

CO

Plutella xylostella

CO

Scirpophaga spp.

CO

Sesamia spp.

CO

Sparganothis spp.

CO

Spodoptera spp.

CO

Tortrix spp.

CO

Trichoplusia ni

CO

Agriotes spp.

CO

Anthonomus grandis

CO

Curculio spp.

CO

Diabrotica balteata

CO

Leptinotarsa spp.

CO

Lissorhoptrus spp.

CO

Otiorhynchus spp.

CO

Aleurothrixus spp.

CO

Aleyrodes spp.

CO

Aonidiella spp.

CO

Aphididae spp.

CO

Aphis spp.

CO

Bemisia tabaci

CO

Empoasca spp.

CO

Mycus spp.

CO

Nephotettix spp.

CO

Nilaparvata spp.

CO

Pseudococcus spp.

CO

Psylla spp.

CO

Quadraspidiotus spp.

CO

Schizaphis spp.

CO

Trialeurodes spp.

CO

Lyriomyza spp.

CO

Oscinella spp.

CO

Phorbia spp.

CO

Frankliniella spp.

CO

Thrips spp.

CO

Scirtothrips aurantii

CO

Aceria spp.

CO

Acutus spp.

CO

Brevipalpus spp.

CO

Panonychus spp.

CO

Phyllocoptruta spp.

CO

Tetranychus spp.

CO

Heterodera spp.

CO

Meloidogyne spp.

CH

Adoxophyes spp.

CH

Agrotis spp.

CH

Alabama argillaceae

CH

Anticarsia

gemmatalis

CH

Chilo spp.

CH

Clysia ambiguella

CH

Crocidolomia binotalis

CH

Cydia spp.

CH

Diparopsis castanea

CH

Earias spp.

CH

Ephestia spp.

CH

Heliothis spp.

CH

Hellula undalis

CH

Keiferia lycopersicella

CH

Leucoptera scitella

CH

Lithocollethis spp.

CH

Lobesia botrana

CH

Ostrinia nubilalis

CH

Pandemis spp.

CH

Pectinophora gossyp.

CH

Phyllocnistis citrella

CH

Pieris spp.

CH

Plutella xylostella

AP

Control of

CH

Scirpophaga spp.

CH

Sesamia spp.

CH

Sparganothis spp.

CH

Spodoptera spp.

CH

Tortrix spp.

CH

Trichoplusia ni

CH

Agriotes spp.

CH

Anthonomus

grandis

CH

Curculio spp.

CH

Diabrotica balteata

CH

Leptinotarsa spp.

CH

Lissorhoptrus spp.

CH

Otiorhynohus spp.

CH

Aleurothrixus spp.

CH

Aleyrodes spp.

CH

Aonidiella spp.

CH

Aphididae spp.

CH

Aphis spp.

CH

Bemisia tabaci

CH

Empoasca spp.

CH

Mycus spp.

CH

Nephotettix spp.

CH

Nilaparvata spp.

CH

Pseudococcus spp.

CH

Psylla spp.

CH

Quadraspidiotus spp.

CH

Schizaphis spp.

CH

Trialeurodes spp.

CH

Lyriomyza spp.

CH

Oscinella spp.

CH

Phorbia spp.

CH

Frankliniella spp.

CH

Thrips spp.

CH

Scirtothrips aurantii

CH

Aceria spp.

CH

Aculus spp.

CH

Brevipalpus spp.

CH

Panonychus spp.

CH

Phyllocoptruta spp.

CH

Tetranychus spp.

CH

Heterodera spp.

CH

Meloidogyne spp.

SS

Adoxophyes spp.

SS

Agrotis spp.

SS

Alabama argillaceae

SS

Anticarsia gemmatalis

SS

Chilo spp.

SS

Clysia ambiguella

SS

Crocidolomia binotalis

SS

Cydia spp.

SS

Diparopsis castanea

SS

Earias spp.

SS

Ephestia spp.

SS

Heliothis spp.

SS

Hellula undalis

SS

Keiferia lycopersicella

SS

Leucoptera scitella

SS

Lithocollethis spp.

SS

Lobesia botrana

SS

Ostrinia nubilalis

SS

Pandemis spp.

SS

Pectinophora gossyp.

SS

Phyllocnistis citrella

SS

Pieris spp.

SS

Plutella xylostella

SS

Scirpophaga spp.

SS

Sesamia spp.

SS

Sparganothis spp.

SS

Spodoptera spp.

SS

Tortrix spp.

SS

Trichoplusia ni

SS

Agriotes spp.

SS

Anthonomus grandis

SS

Curculio spp.

SS

Diabrotica balteata

SS

Leptinotarsa spp.

SS

Lissorhoptrus spp.

SS

Otiorhynchus spp.

SS

Aleurothrixus spp.

SS

Aleyrodes spp.

SS

Aonidiella spp.

SS

Aphididae spp.

SS

Aphis spp.

SS

Bemisia tabaci

SS

Empoasca spp.

SS

Mycus spp.

SS

Nephotettix spp.

SS

Nilaparvata spp.

SS

Pseudococcus spp.

SS

Psylla spp.

SS

Quadraspidiotus spp.

SS

Schizaphis spp.

SS

Trialeurodes spp.

SS

Lyriomyza spp.

SS

Oscinella spp.

SS

Phorbia spp.

SS

Frankliniella spp.

SS

Thrips spp.

SS

Scirtothrips aurantii

SS

Aceria spp.

SS

Aculus spp.

SS

Brevipalpus spp.

SS

Panonychus spp.

SS

Phyllocoptruta spp.

SS

Tetranychus spp.

SS

Heterodera spp.

SS

Meloidogyne spp.

HO

Adoxophyes spp.

HO

Agrotis spp.

HO

Alabama argillaceae

HO

Anticarsia gemmatalis

HO

Chilo spp.

HO

Clysia ambiguella

HO

Crocidolomia binotalis

HO

Cydia spp.

HO

Diparopsis castanea

HO

Earias spp.

HO

Ephestia spp.

HO

Heliothis spp.

HO

Hellula undalis

HO

Keiferia lycopersicella

HO

Leucoptera scitella

HO

Lithocollethis spp.

HO

Lobesia botrana

HO

Ostrinia nubilalis

HO

Pandemis spp.

HO

Pectinophora gossypiella

HO

Phyllocnistis citrella

HO

Pieris spp.

HO

Plutella xylostella

HO

Scirpophaga spp.

HO

Sesamia spp.

HO

Sparganothis spp.

HO

Spodoptera spp.

HO

Tortrix spp.

HO

Trichoplusia ni

HO

Agriotes spp.

HO

Anthonomus grandis

HO

Curculio spp.

HO

Diabrotica balteata

HO

Leptinotarsa spp.

HO

Lissorhoptrus spp.

HO

Otiorhynchus spp.

HO

Aleurothrixus spp.

HO

Aleyrodes spp.

HO

Aonidiella spp.

HO

Aphididae spp.

HO

Aphis spp.

HO

Bemisia tabaci

HO

Empoasca spp.

HO

Mycus spp.

HO

Nephotettix spp.

HO

Nilaparvata spp.

HO

Pseudococcus spp.

HO

Psylla spp.

HO

Quadraspidiotus spp.

HO

Schizaphis spp.

HO

Trialeurodes spp.

HO

Lyriomyza spp.

HO

Oscinella spp.

HO

Phorbia spp.

HO

Frankliniella spp.

HO

Thrips spp.

HO

Scirtothrips aurantii

HO

Aceria spp.

HO

Acutus spp.

HO

Brevipalpus spp.

HO

Panonychus spp.

HO

Phyllocoptruta spp.

HO

Tetranychus spp.

HO

Heterodera spp.

HO

Meloidogyne spp.

In the table, the following abbreviations were used:

active principle of the transgenic plant: AP

Photorhabdus luminescens: PL

Xenorhabdus nematophilus: XN

proteinase inhibitors: Plnh.

plant lectins PLec.

agglutinines: Aggl.

3-hydroxysteroid oxidase: HO

cholesterol oxidase: CO

chitinase: CH

glucanase: GL

stilbene synthase: SS

TABLE 3

Principle
Tolerance to
Plant

ALS
sulphonylurea compounds etc.***
cotton

ALS
sulphonylurea compounds etc.***
rice

ALS
sulphonylurea compounds etc.***

Brassica

ALS
sulphonylurea compounds etc.***
potatoes

ALS
sulphonylurea compounds etc.***
tomatoes

ALS
sulphonylurea compounds etc.***
pumpkin

ALS
sulphonylurea compounds etc.***
soya beans

ALS
sulphonylurea compounds etc.***
maize

ALS
sulphonylurea compounds etc.***
wheat

ALS
sulphonylurea compounds etc.***
pome fruit

ALS
sulphonylurea compounds etc.***
stone fruit

ALS
sulphonylurea compounds etc.***
citrus fruit

ACCase
+++
cotton

ACCase
+++
rice

ACCase
+++

Brassica

ACCase
+++
potato

ACCase
+++
tomatoes

ACCase
+++
pumpkin

ACCase
+++
soya beans

ACCase
+++
maize

ACCase
+++
wheat

ACCase
+++
pome fruit

ACCase
+++
stone fruit

ACCase
+++
citrus fruit

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
cotton

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
rice

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,

Brassica

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
potatoes

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
tomatoes

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
pumpkin

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
soya beans

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
maize

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
wheat

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
pome fruit

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
stone fruit

mesotrione

HPPD
isoxaflutole, isoxachlortole, sulcotrione,
citrus fruit

mesotrione

nitrilase
bromoxynil, loxynil
cotton

nitrilase
bromoxynil, loxynil
rice

nitrilase
bromoxynil, loxynil

Brassica

nitrilase
bromoxynil, loxynil
potatoes

nitrilase
bromoxynil, loxynil
tomatoes

nitrilase
bromoxynil, loxynil
pumpkin

nitrilase
bromoxynil, loxynil
soya beans

nitrilase
bromoxynil, loxynil
maize

nitrilase
bromoxynil, loxynil
wheat

nitrilase
bromoxynil, loxynil
pome fruit

nitrilase
bromoxynil, loxynil
stone fruit

nitrilase
bromoxynil, loxynil
citrus fruit

IPS
chloroactanilides &&&
cotton

IPS
chloroactanilides &&&
rice

IPS
chloroactanilides &&&

Brassica

IPS
chloroactanilides &&&
potatoes

IPS
chloroactanilides &&&
tomatoes

IPS
chloroactanilides &&&
pumpkin

IPS
chloroactanilides &&&
soya beans

IPS
chloroactanilides &&&
maize

IPS
chloroactanilides &&&
wheat

IPS
chloroactanilides &&&
pome fruit

IPS
chloroactanilides &&&
stone fruit

IPS
chloroactanilides &&&
citrus fruit

HOM
2,4-D, mecoprop-P
cotton

HOM
2,4-D, mecoprop-P
rice

HOM
2,4-D, mecoprop-P

Brassica

HOM
2,4-D, mecoprop-P
potatoes

HOM
2,4-D, mecoprop-P
tomatoes

HOM
2,4-D, mecoprop-P
pumpkin

HOM
2,4-D, mecoprop-P
soya beans

HOM
2,4-D, mecoprop-P
maize

HOM
2,4-D, mecoprop-P
wheat

HOM
2,4-D, mecoprop-P
pome fruit

HOM
2,4-D, mecoprop-P
stone fruit

HOM
2,4-D, mecoprop-P
citrus fruit

PROTOX
Protox inhibitors ///
cotton

PROTOX
Protox inhibitors ///
rice

PROTOX
Protox inhibitors ///

Brassica

PROTOX
Protox inhibitors ///
potatoes

PROTOX
Protox inhibitors ///
tomatoes

PROTOX
Protox inhibitors ///
pumpkin

PROTOX
Protox inhibitors ///
soya beans

PROTOX
Protox inhibitors ///
maize

PROTOX
Protox inhibitors ///
wheat

PROTOX
Protox inhibitors ///
pome fruit

PROTOX
Protox inhibitors ///
stone fruit

PROTOX
Protox inhibitors ///
citrus fruit

EPSPS
glyphosate and/or sulphosate
cotton

EPSPS
glyphosate and/or sulphosate
rice

EPSPS
glyphosate and/or sulphosate

Brassica

EPSPS
glyphosate and/or sulphosate
potatoes

EPSPS
glyphosate and/or sulphosate
tomatoes

EPSPS
glyphosate and/or sulphosate
pumpkin

EPSPS
glyphosate and/or sulphosate
soya beans

EPSPS
glyphosate and/or sulphosate
maize

EPSPS
glyphosate and/or sulphosate
wheat

EPSPS
glyphosate and/or sulphosate
pome fruit

EPSPS
glyphosate and/or sulphosate
stone fruit

EPSPS
glyphosate and/or sulphosate
citrus fruit

GS
gluphosinate and/or bialaphos
cotton

GS
gluphosinate and/or bialaphos
rice

GS
gluphosinate and/or bialaphos

Brassica

GS
gluphosinate and/or bialaphos
potatoes

GS
gluphosinate and/or bialaphos
tomatoes

GS
gluphosinate and/or bialaphos
pumpkin

GS
gluphosinate and/or bialaphos
soya beans

GS
gluphosinate and/or bialaphos
maize

GS
gluphosinate and/or bialaphos
wheat

GS
gluphosinate and/or bialaphos
pome fruit

GS
gluphosinate and/or bialaphos
stone fruit

GS
gluphosinate and/or bialaphos
citrus fruit

***included are sulphonylurea compounds, imidazolinones, triazolopyrimidines, dimethoxypyrimidines and N-acylsulphonamides: sulphonylurea compounds such as chlorsulfuron, chlorimuron, ethamethsulfuron, metsulfuron, primisulfuron, prosulfuron, triasulfuron, cinosulfuron, trifusulfuron, oxasulfuron, bensulfuron, tribenuron, ACC 322140, fluzasulfuron, ethoxysulfuron, fluzadsulfuron, nicosulfuron, rimsulfuron, thifensulfuron, pyrazosulfuron, clopyrasulfuron, NC 330, azimsulfuron, imazosulfuron, sulfosulfuron, amidosulfuron, flupyrsulfuron, CGA 362622 imidazolinones such as imazamethabenz, imazaquin, imazamethypyr, imazethapyr, imazapyr and imazamox; triazolopyrimidines such as DE 511, flumetsulam and chloransulam; dimethoxypyrimidines such as, for example, pyrithiobac, pyriminobac, bispyribac and pyribenzoxim.

+++ Tolerance to diclofop-methyl, fluazifop-P-butyl, haloxyfop-P-methyl, haloxyfop-P-ethyl, quizalafop-P-ethyl, clodinafop-propargyl, fenoxaprop-ethyl, tepraloxydim, alloxydim, sethoxydim, cycloxydim, cloproxydim, tralkoxydim, butoxydim, caloxydim, clefoxydim, clethodim.

&&& chloroacetanilides such as, for example, alachlor, acetochlor, dimethenamid

/// Protox inhibitors: for example diphenyl ethers such as, for example, acifluorfen, aclonifen, bifenox, chlornitrofen, ethoxyfen, fluoroglycofen, fomesafen, lactofen, oxyfluorfen; imides such as, for example, azafenidin, carfentrazone-ethyl, cinidon-ethyl, flumiclorac-pentyl, flumioxazin, fluthiacet-methyl, oxadiargyl, oxadiazon, pentoxazone, sulfentrazone, imides and other compounds such as, for example, flumipropyn, flupropacil, nipyraclofen and thidiazimin; and also fluazola and pyraflufen-ethyl.

Abbreviations:

acetyl-CoA carboxylase: ACCase

acetolactate synthase: ALS

hydroxyphenylpyruvate dioxygenase: HPPD

inhibition of protein synthesis: IPS

hormone imitation: HO

glutamine synthetase: GS

protoporphyrinogen oxidase: PROTOX

5-enolpyruvyl-3-phosphoshikimate synthase: EPSPS

TABLE 4

List of examples of transgenic plants having modified properties:

Transgenic plants
Transgenically modified properties

Dianthus caryophyllus (carnation)
Longer-lasting as a result of reduced ethylene

Line 66
accumulation owing to the expression of ACC

[Florigene Pty. Ltd.]
synthase; tolerant to sulphonylurea herbicides

Dianthus caryophyllus (carnation)
Modified flower colour; tolerant to sulphonyl-

Lines 4, 11, 15, 16
urea herbicides

[Florigene Pty. Ltd.]

Dianthus caryophyllus (carnation)
Modified flower colour; tolerant to sulphonyl-

Lines 959A, 988A, 1226A, 1351A, 1363A,
urea herbicides

1400A

[Florigene Pty. Ltd.]

Brassica napus (Argentine oilseed rape)
Modified fatty acid content in the seeds

Lines 23-18-17, 23-198

[Monsanto Company]

Zea mays L. (maize)
Elevated lysine content

Lines REN-ØØØ38-3 (LY038)

[Monsanto Company]

Zea mays L. (maize)
Elevated lysine content, corn borer resistant

Lines REN-ØØØ38-3, MON-ØØ81Ø-6

(MON-ØØ81Ø-6 x LY038)

[Monsanto Company]

Cucumis melo (melon)
Delayed maturity as a result of the expression of

Lines A, B
S-adenosylmethionine hydrolase

[Agritope Inc.]

Carica papaya (papaya)
Resistant to the papaya ring spot virus (PRSV)

Lines 55-1/63-1

[Cornell University]

Solanum tuberosum L. (potato)
Resistant to the Colorado beetle and the potato

Lines RBMT21-129, RBMT21-350, RBMT22-
leaf roll virus (PLRV)

082

[Monsanto Company]

Solanum tuberosum L. (potato)
Resistant to the Colorado beetle and the potato

Lines RBMT15-101, SEMT15-02, SEMT15-15
virus Y (PVY)

[Monsanto Company]

Glycine max L. (soyabean)
Modified fatty acid content in the seeds, in

Lines DD-Ø26ØØ5-3 (G94-1, G94-19, G168
particular elevated oleic acid content

[DuPont Canada Agricultural Products]

Glycine max L. (soyabean)
Modified fatty acid content in the seeds, in

Lines OT96-15
particular reduced linolenic acid content

[Agriculture & Agri-Food Canada]

Cucurbita pepo (pumpkin)
Resistant to viral infections, watermelon mosaic

Line ZW20
virus (WMV) 2 and zucchini yellow mosaic

[Upjohn (USA); Seminis Vegetable Inc.
virus (ZYMV)

(Canada)]

Cucurbita pepo (pumpkin)
Resistance to viral infections, cucumber mosaic

Line CZW-3
virus (CMV), watermelon mosaic virus (WMV)

[Asgrow (USA); Seminis Vegetable Inc.
2 and zucchini yellow mosaic virus (ZYMV)

(Canada)]

Nicotiana tabacum L. (tobacco)
Reduced nicotine content

Line Vector 21-41

[Vector Tobacco]

Lycopersicon esculentum (tomato)
Longer lasting as a result of reduced ethylene

Line 1345-4
accumulation owing to the expression of ACC

[DNA Plant Technology]
synthase

Lycopersicon esculentum (tomato)
Delayed maturity as a result of the expression of

Line 35 1 N
S-adenosylmethionine hydrolase

[Agritope Inc.]

Lycopersicon esculentum (tomato)
Delayed maturity as a result of the expression of

Line CGN-89322-3 (8338)
ACCd

[Monsanto Company]

Lycopersicon esculentum (tomato)
Delayed softening as a result of a reduced

Lines B, Da, F
expression of polygalacturonase

[Zeneca Seeds]

Lycopersicon esculentum (tomato)
Delayed softening as a result of a reduced

Line CGN-89564-2 (FLAVR SAVR)
expression of polygalacturonase

[Calgene Inc.]

TABLE 5

No.
Line/trait
Commercial name

Plant

B-1
ASR368

Agrostis stolonifera

Creeping Bentgrass

B-2
H7-1
Roundup Ready Sugar

Beta vulgaris (Sugar Beet)

Beet

B-3
T120-7

Beta vulgaris (Sugar Beet)

B-4
GTSB77

Beta vulgaris (Sugar Beet)

B-5
23-18-17, 23-198

Brassica napus (Argentine

Canola)

B-6
45A37, 46A40

Brassica napus (Argentine

Canola)

B-7
46A12, 46A16

Brassica napus (Argentine

Canola)

B-8
GT200

Brassica napus (Argentine

Canola)

B-9
GT73, RT73
Roundup Ready ™

Brassica napus (Argentine

canola
Canola)

B-10
HCN10

Brassica napus (Argentine

Canola)

B-11
Topas 19/2
InVigor ® Canola

Brassica napus (Argentine

(HCN92)

Canola)

B-12
MS1, RF1 =>PGS1

Brassica napus (Argentine

Canola)

B-13
MS1, RF2 =>PGS2

Brassica napus (Argentine

Canola)

B-14
MS8 × RF3
InVigor ® Canola

Brassica napus (Argentine

Canola)

B-15
NS738, NS1471,

Brassica napus (Argentine

NS1473

Canola)

B-16
OXY-235

Brassica napus (Argentine

Canola)

B-17
MS8
InVigor ® Canola

Brassica napus (Argentine

Canola)

B-18
PHY14, PHY35

Brassica napus (Argentine

Canola)

B-19
PHY36

Brassica napus (Argentine

Canola)

B-20
RF1, (B93-101)
InVigor ® Canola

Brassica napus (Argentine

Canola)

B-21
RF2, (B94-101)

Brassica napus (Argentine

Canola)

B-22
RF3, ACS-
InVigor ® Canola

Brassica napus (Argentine

BNØØ3-6

Canola)

B-23
MS1 (B91-4)
InVigor ® Canola

Brassica napus (Argentine

Canola)

B-24
T45 (HCN28)
InVigor ® Canola

Brassica napus (Argentine

Canola)

B-25
HCR-1

Brassica rapa (Polish

Canola)

B-26
ZSR500/502

Brassica rapa (Polish

Canola)

B-27
55-1/63-1

Carica papaya (Papaya)

B-28
RM3-3, RM3-4,

Cichorium intybus (Chicory)

RM3-6

B-29
A, B

Cucumis melo (Melon)

B-30
CZW-3

Cucurbita pepo (Squash)

B-31
ZW20

Cucurbita pepo (Squash)

B-32
66

Dianthus

caryophyllus (Carnation)

B-33
4, 11, 15, 16

Dianthus

caryophyllus (Carnation)

B-34
11363
Moonshadow

Dianthus

caryophyllus (Carnation)

B-35
959A, 988A,

Dianthus

1226A, 1351A,

caryophyllus (Carnation)

1363A, 1400A

B-36
123.2. (40619)
Moonshade

Dianthus

caryophyllus (Carnation)

B-37
123.8.8 (40685)
Moonvista

Dianthus

caryophyllus (Carnation)

B-38
11 (7442)
Moondust

Dianthus

caryophyllus (Carnation)

B-39
A2704-12, A2704-

Glycine max L. (Soybean)

21, A5547-35

B-40
A5547-127
LibertyLink ® Soybean

Glycine max L. (Soybean)

B-41
G94-1, G94-19,

Glycine max L. (Soybean)

G168

B-42
GTS 40-3-2
Roundup Ready ™

Glycine max L. (Soybean)

soybeans

B-43
GU262

Glycine max L. (Soybean)

B-44
MON89788
Roundup

Glycine max L. (Soybean)

RReady2Yield ™

soybean

B-45
OT96-15

Glycine max L. (Soybean)

B-46
W62, W98

Glycine max L. (Soybean)

B-47
15985
Bollgard II cotton

Gossypium hirsutum L.

(Cotton)

B-48
19-51A

Gossypium hirsutum L.

(Cotton)

B-49
281-24-236

Gossypium hirsutum L.

(Cotton)

B-50
3006-210-23
WideStrike ™

Gossypium hirsutum L.

(Cotton)

B-51
31807/31808

Gossypium hirsutum L.

(Cotton)

B-52
BXN

Gossypium hirsutum L.

(Cotton)

B-53
COT102

Gossypium hirsutum L.

(Cotton)

B-54
DAS-21Ø23-5 ×

Gossypium hirsutum L.

DAS-24236-5

(Cotton)

B-55
DAS-21Ø23-5 ×

Gossypium hirsutum L.

DAS-24236-5 ×

(Cotton)

MON88913

B-56
DAS-21Ø23-5 ×

Gossypium hirsutum L.

DAS-24236-5 ×

(Cotton)

MON-Ø1445-2

B-57
LLCotton25

Gossypium hirsutum L.

(Cotton)

B-58
LLCotton25 ×

Gossypium hirsutum L.

MON15985

(Cotton)

B-59
MON1445/1698
Roundup Ready ™

Gossypium hirsutum L.

cotton
(Cotton)

B-60
MON15985 ×

Gossypium hirsutum L.

MON88913

(Cotton)

B-61
MON-15985-7 ×

Gossypium hirsutum L.

MON-Ø1445-2

(Cotton)

B-62
MON531/757/1076
Bollgard ™ (Ingard ®)

Gossypium hirsutum L.

(Cotton)

B-63
MON88913
Roundup Ready Flex

Gossypium hirsutum L.

Cotton
(Cotton)

B-64
MON-ØØ531-6 ×

Gossypium hirsutum L.

MON-Ø1445-2

(Cotton)

B-65
T304-40

Gossypium hirsutum L.

(Cotton)

B-66
GHB714

Gossypium hirsutum L.

(Cotton)

B-67
GHB119

Gossypium hirsutum L.

(Cotton)

B-68
T303-3

Gossypium hirsutum L.

(Cotton)

B-69
GHB614

Gossypium hirsutum L.

(Cotton)

B-70
X81359

Helianthus

annuus (Sunflower)

B-71
RH44

Lens culinaris (Lentil)

B-72
FP967

Linum usitatissimum L.

(Flax, Linseed)

B-73
5345

Lycopersicon

esculentum (Tomato)

B-74
8338

Lycopersicon

esculentum (Tomato)

B-75
1345-4

Lycopersicon

esculentum (Tomato)

B-76
35 1 N

Lycopersicon

esculentum (Tomato)

B-77
B, Da, F

Lycopersicon

esculentum (Tomato)

B-78
FLAVR SAVR
FLAVR SAVR

Lycopersicon

esculentum (Tomato)

B-79
J101, J163
Roundup Ready

Medicago sativa (Alfalfa)

Alfalfa

B-80
C/F/93/08-02

Nicotiana tabacum L.

(Tobacco)

B-81
Vector 21-41

Nicotiana tabacum L.

(Tobacco)

B-82
CL121, CL141,

Oryza sativa (Rice)

CFX51

B-83
IMINTA-1,
Clearfield ™

Oryza sativa (Rice)

IMINTA-4

B-84
LLRICE06,
LibertyLink ® Rice

Oryza sativa (Rice)

LLRICE62

B-85
LLRICE601

Oryza sativa (Rice)

B-86
PWC16

Oryza sativa (Rice)

B-87
ATBT04-6,
NewLeaf Atlantic

Solanum tuberosum L.

ATBT04-27,

(Potato)

ATBT04-30,

ATBT04-31,

ATBT04-36,

SPBT02-5,

SPBT02-7

B-88
BT6, BT10, BT12,
NewLeaf Russet

Solanum tuberosum L.

BT16, BT17,
Burbank
(Potato)

BT18, BT23

B-89
RBMT15-101,

Solanum tuberosum L.

SEMT15-02,

(Potato)

SEMT15-15

B-90
RBMT21-129,

Solanum tuberosum L.

RBMT21-350,

(Potato)

RBMT22-082

B-91
AM02-1003,

Solanum tuberosum L.

AM01-1005,

(Potato)

AM02-1012,

AM02-1017,

AM99-1089 and

AM99-2003

B-92
EH92-527-1
Amflora

Solanum tuberosum L.

(Potato)

B-93
AP205CL

Triticum aestivum (Wheat)

B-94
AP602CL

Triticum aestivum (Wheat)

B-95
BW255-2, BW238-3
Clearfield ™

Triticum aestivum (Wheat)

B-96
MON71800

Triticum aestivum (Wheat)

B-97
SWP965001

Triticum aestivum (Wheat)

B-98
DW2, DW6,
Clearfield ™

Triticum aestivum (Wheat)

DW12

B-99
BW7
Clearfield ™

Triticum aestivum (Wheat)

B-100
Teal 11A

Triticum aestivum (Wheat)

B-101
176
Knockout ™,

Zea mays L. (Maize)

NautureGard ™

B-102
3751IR

Zea mays L. (Maize)

B-103
676, 678, 680
LibertyLink ® Male

Zea mays L. (Maize)

Sterile

B-104
ACS-ZMØØ3-2 ×

Zea mays L. (Maize)

MON-ØØ81Ø-6

B-105
B16 (DLL25)

Zea mays L. (Maize)

B-106
BT11 (X4334CBR,
BiteGard ®

Zea mays L. (Maize)

X4734CBR)

B-107
CBH-351
StarLink ®

Zea mays L. (Maize)

B-108
DAS-06275-8

Zea mays L. (Maize)

B-109
DAS-59122-7
Herculex RW

Zea mays L. (Maize)

Rootworm Protection

Maise

B-110
DAS-59122-7 ×

Zea mays L. (Maize)

NK603

B-111
DAS-59122-7 ×

Zea mays L. (Maize)

TC1507 × NK603

B-112
DAS-Ø15Ø7-1 ×

Zea mays L. (Maize)

MON-ØØ6Ø3-6

B-113
DBT418
Bt-XTRA ®

Zea mays L. (Maize)

B-114
DK404SR

Zea mays L. (Maize)

B-115
EXP1910IT

Zea mays L. (Maize)

B-116
GA21
Roundup Ready ®

Zea mays L. (Maize)

B-117
IT

Zea mays L. (Maize)

B-118
LY038
Mavera ™ High Value

Zea mays L. (Maize)

Corn with Lysine

B-119
MIR604
Agrisure RW

Zea mays L. (Maize)

Rootworm-Protected

Corn

B-120
MON80100

Zea mays L. (Maize)

B-121
MON802
Roundup Ready ®

Zea mays L. (Maize)

B-122
MON809

Zea mays L. (Maize)

B-123
MON810
YieldGard ®

Zea mays L. (Maize)

B-124
MON810 ×

Zea mays L. (Maize)

MON88017

B-125
MON832

Zea mays L. (Maize)

B-126
MON863
YieldGard ®

Zea mays L. (Maize)

Rootworm

B-127
MON88017

Zea mays L. (Maize)

B-128
MON-ØØ6Ø3-6 ×

Zea mays L. (Maize)

MON-ØØ81Ø-6

B-129
MON-ØØ81Ø-6 ×

Zea mays L. (Maize)

LY038

B-130
MON-ØØ863-5 ×

Zea mays L. (Maize)

MON-ØØ6Ø3-6

B-131
MON-ØØ863-5 ×
YieldGard ® Plus

Zea mays L. (Maize)

MON-ØØ81Ø-6

B-132
MON-ØØ863-5 ×
YieldGard ® Plus,

Zea mays L. (Maize)

MON-ØØ81Ø-6 ×
Roundup Ready ®

MON-ØØ6Ø3-6

B-133
MON-ØØØ21-9 ×

Zea mays L. (Maize)

MON-ØØ81Ø-6

B-134
MS3

Zea mays L. (Maize)

B-135
MS6
LibertyLink ® Male

Zea mays L. (Maize)

Sterile

B-136
NK603
Roundup Ready ® corn

Zea mays L. (Maize)

B-137
SYN-BTØ11-1 ×

Zea mays L. (Maize)

MON-ØØØ21-9

B-138
T14, T25
LibertyLink ™

Zea mays L. (Maize)

B-139
TC1507
Herculex I ®

Zea mays L. (Maize)

B-140
TC1507 × DAS-

Zea mays L. (Maize)

59122-7

B-141
SYTGA21

Zea mays L. (Maize)

B-142
SYTGA21 + Btl1

Zea mays L. (Maize)

B-143
MON810 +

Zea mays L. (Maize)

SYTGA21

B-144
MON89034

Zea mays L. (Maize)

B-145
MON 89034 ×

Zea mays L. (Maize)

MON 88017

B-146
MON 89034 ×

Zea mays L. (Maize)

NK603

B-147
DP-Ø9814Ø-6

Zea mays L. (Maize)

B-148
3243M

Zea mays L. (Maize)

B-149
DP 444 BG/RR
Bollgard/RoundupReady,

Gossypium hirsutum

from US
L. (Cotton)

2003213029-A1

B-150
VSN-BTCRW
Bt-toxin corn root

Zea mays L. (Maize)

worm

B-151
HCL201CRW2RR ×
Bt-toxin corn root

Zea mays L. (Maize)

LH324
worm

B-152
LH324
from U.S. Pat. No. 7,223,908 B1

Zea mays L. (Maize)

B-153
VSN-RR Bt
RoundupReady Bt-

Zea mays L. (Maize)

toxin

B-154
FR1064LL ×
Ref: Gerdes, J. T.,

Zea mays L. (Maize)

FR2108
Behr, C. F., Coors, J. G.,

and Tracy, W. F.

1993. Compilation

of North American

Maize Breeding

Germplasm. W. F. Tracy,

J. G. Coors,

and J. L. Geadelmann,

eds.

Crop Science Society

of America,

Madison, WI and U.S. Pat. No.

6,407,320 B1

B-155
VSN-Bt
Bt-toxin

Zea mays L. (Maize)

No.
Company
Transgenically modified properties

B-1
Scotts Seeds
Glyphosate tolerance derived by inserting a

modified 5-enolpyruvylshikimate-3-phosphate

synthase (EPSPS) encoding gene from

Agrobacterium tumefaciens.

B-2
Monsanto Company
Glyphosate herbicide tolerant sugar beet produced

by inserting a gene encoding the enzyme 5-

enolypyruvylshikimate-3-phosphate synthase

(EPSPS) from the CP4 strain of Agrobacterium

tumefaciens.

B-3
Bayer CropScience
Introduction of the PPT-acetyltransferase (PAT)

(Aventis
encoding gene from Streptomyces

CropScience(AgrEvo))

viridochromogenes, an aerobic soil bacteria. PPT

normally acts to inhibit glutamine synthetase,

causing a fatal accumulation of ammonia.

Acetylated PPT is inactive.

B-4
Novartis Seeds; Monsanto
Glyphosate herbicide tolerant sugar beet produced

Company
by inserting a gene encoding the enzyme 5-

enolypyruvylshikimate-3-phosphate synthase

(EPSPS) from the CP4 strain of Agrobacterium

tumefaciens.

B-5
Monsanto Company
High laurate (12:0) and myristate (14:0) canola

(formerly Calgene)
produced by inserting a thioesterase encoding

gene from the California bay laurel (Umbellularia

californica).

B-6
Pioneer Hi-Bred
High oleic acid and low linolenic acid canola

International Inc.
produced through a combination of chemical

mutagenesis to select for a fatty acid desaturase

mutant with elevated oleic acid, and traditional

back-crossing to introduce the low linolenic acid

trait.

B-7
Pioneer Hi-Bred
Combination of chemical mutagenesis, to achieve

International Inc.
the high oleic acid trait, and traditional breeding

with registered canola varieties.

B-8
Monsanto Company
Glyphosate herbicide tolerant canola produced by

inserting genes encoding the enzymes 5-

enolypyruvylshikimate-3-phosphate synthase

(EPSPS) from the CP4 strain of Agrobacterium

tumefaciens and glyphosate oxidase from

Ochrobactrum anthropi.

B-9
Monsanto Company
Glyphosate herbicide tolerant canola produced by

inserting genes encoding the enzymes 5-

enolypyruvylshikimate-3-phosphate synthase

(EPSPS) from the CP4 strain of Agrobacterium

tumefaciens and glyphosate oxidase from

Ochrobactrum anthropi.

B-10
Aventis CropScience
Introduction of the PPT-acetyltransferase (PAT)

encoding gene from Streptomyces

viridochromogenes, an aerobic soil bacteria. PPT

normally acts to inhibit glutamine synthetase,

causing a fatal accumulation of ammonia.

Acetylated PPT is inactive.

B-11
Bayer CropScience
Introduction of the PPT-acetyltransferase (PAT)

(Aventis
encoding gene from Streptomyces

CropScience(AgrEvo))

viridochromogenes, an aerobic soil bacteria. PPT

normally acts to inhibit glutamine synthetase,

causing a fatal accumulation of ammonia.

Acetylated PPT is inactive.

B-12
Aventis CropScience
Male-sterility, fertility restoration, pollination

(formerly Plant Genetic
control system displaying glufosinate herbicide

Systems)
tolerance. MS lines contained the barnase gene

from Bacillus amyloliquefaciens, RF lines

contained the barstar gene from the same bacteria,

and both lines contained the phosphinothricin N-

acetyltransferase (PAT) encoding gene from

Streptomyces hygroscopicus.

B-13
Aventis CropScience
Male-sterility, fertility restoration, pollination

(formerly Plant Genetic
control system displaying glufosinate herbicide

Systems)
tolerance. MS lines contained the barnase gene

from Bacillus amyloliquefaciens, RF lines

contained the barstar gene from the same bacteria,

and both lines contained the phosphinothricin N-

acetyltransferase (PAT) encoding gene from

Streptomyces hygroscopicus.

B-14
Bayer CropScience
Male-sterility, fertility restoration, pollination

(Aventis
control system displaying glufosinate herbicide

CropScience(AgrEvo))
tolerance. MS lines contained the barnase gene

from Bacillus amyloliquefaciens, RF lines

contained the barstar gene from the same bacteria,

and both lines contained the phosphinothricin N-

acetyltransferase (PAT) encoding gene from

Streptomyces hygroscopicus.

B-15
Pioneer Hi-Bred
Selection of somaclonal variants with altered

International Inc.
acetolactate synthase (ALS) enzymes, following

chemical mutagenesis. Two lines (P1, P2) were

initially selected with modifications at different

unlinked loci. NS738 contains the P2 mutation

only.

B-16
Aventis CropScience
Tolerance to the herbicides bromoxynil and

(formerly Rhone Poulenc
ioxynil by incorporation of the nitrilase gene

Inc.)
(oxy) from Klebsiella pneumoniae.

B-17
Bayer CropScience
Traits: Glufosinate tolerance, Male sterility

Genes: bar, barnase

B-18
Aventis CropScience
Male sterility was via insertion of the barnase

(formerly Plant Genetic
ribonuclease gene from Bacillus

Systems)

amyloliquefaciens; fertility restoration by

insertion of the barstar RNase inhibitor; PPT

resistance was via PPT-acetyltransferase (PAT)

from Streptomyces hygroscopicus.

B-19
Aventis CropScience
Male sterility was via insertion of the barnase

(formerly Plant Genetic
ribonuclease gene from Bacillus

Systems)

amyloliquefaciens; fertility restoration by

insertion of the barstar RNase inhibitor; PPT

resistance was via PPT-acetyltransferase (PAT)

from Streptomyces hygroscopicus.

B-20
Bayer CropScience
Genes: bar, barstar, neomycin phosphotransferase

II (npt II); Traits: Fertility restoration, Glufosinate

tolerance, Kanamycin resistance

B-21
Bayer CropScience
Genes: bar, barstar, neomycin phosphotransferase

II (npt II); Traits: Fertility restoration, Glufosinate

tolerance, Kanamycin resistance

B-22
Bayer CropScience
Traits: Fertility restoration, Glufosinate tolerance;

Genes bar, barstar

B-23
Bayer CropScience
Traits: Glufosinate tolerance, Kanamycin

resistance, Male sterility; Genes:

bar, barnase, neomycin phosphotransferase II (npt

II)

B-24
Bayer CropScience
Introduction of the PPT-acetyltransferase (PAT)

(Aventis
encoding gene from Streptomyces

CropScience(AgrEvo))

viridochromogenes, an aerobic soil bacteria. PPT

normally acts to inhibit glutamine synthetase,

causing a fatal accumulation of ammonia.

Acetylated PPT is inactive.

B-25
Bayer CropScience
Introduction of the glufosinate ammonium

(Aventis
herbicide tolerance trait from transgenic B. napus

CropScience(AgrEvo))
line T45. This trait is mediated by the

phosphinothricin acetyltransferase (PAT)

encoding gene from S. viridochromogenes.

B-26
Monsanto Company
Introduction of a modified 5-enol-

pyruvylshikimate-3-phosphate synthase (EPSPS)

and a gene from Achromobacter sp that degrades

glyphosate by conversion to

aminomethylphosphonic acid (AMPA) and

glyoxylate by interspecific crossing with GT73.

B-27
Cornell University
Papaya ringspot virus (PRSV) resistant papaya

produced by inserting the coat protein (CP)

encoding sequences from this plant potyvirus.

B-28
Bejo Zaden BV
Male sterility was via insertion of the barnase

ribonuclease gene from Bacillus

amyloliquefaciens; PPT resistance was via the bar

gene from S. hygroscopicus, which encodes the

PAT enzyme.

B-29
Agritope Inc.
Reduced accumulation of S-adenosylmethionine

(SAM), and consequently reduced ethylene

synthesis, by introduction of the gene encoding S-

adenosylmethionine hydrolase.

B-30
Asgrow (USA); Seminis
Cucumber mosiac virus (CMV), zucchini yellows

Vegetable Inc. (Canada)
mosaic (ZYMV) and watermelon mosaic virus

(WMV) 2 resistant squash (Curcurbita pepo)

produced by inserting the coat protein (CP)

encoding sequences from each of these plant

viruses into the host genome.

B-31
Upjohn (USA); Seminis
Zucchini yellows mosaic (ZYMV) and

Vegetable Inc. (Canada)
watermelon mosaic virus (WMV) 2 resistant

squash (Curcurbita pepo) produced by inserting

the coat protein (CP) encoding sequences from

each of these plant potyviruses into the host

genome.

B-32
Florigene Pty Ltd.
Delayed senescence and sulfonylurea herbicide

tolerant carnations produced by inserting a

truncated copy of the carnation

aminocyclopropane cyclase (ACC) synthase

encoding gene in order to suppress expression of

the endogenous unmodified gene, which is

required for normal ethylene biosynthesis.

Tolerance to sulfonyl urea herbicides was via the

introduction of a chlorsulfuron tolerant version of

the acetolactate synthase (ALS) encoding gene

from tobacco.

B-33
Florigene Pty Ltd.
Modified colour and sulfonylurea herbicide

tolerant carnations produced by inserting two

anthocyanin biosynthetic genes whose expression

results in a violet/mauve colouration. Tolerance to

sulfonyl urea herbicides was via the introduction

of a chlorsulfuron tolerant version of the

acetolactate synthase (ALS) encoding gene from

tobacco.

B-34
Florigene Pty Ltd.
Traits: Coloration; Genes als, dihydroflavonol

reductase (dfr), flavonoid 3′,5′hydroxylase (F3′5′H)

B-35
Florigene Pty Ltd.
Introduction of two anthocyanin biosynthetic

genes to result in a violet/mauve colouration;

Introduction of a variant form of acetolactate

synthase (ALS).

B-36
Florigene Pty Ltd.
Traits: Coloration; Genes als, dihydroflavonol

reductase (dfr), flavonoid 3′,5′hydroxylase (F3′5′H)

B-37
Florigene Pty Ltd.

B-38
Florigene Pty Ltd.

B-39
Aventis CropScience
Glufosinate ammonium herbicide tolerant

soybean produced by inserting a modified

phosphinothricin acetyltransferase (PAT)

encoding gene from the soil bacterium

Streptomyces viridochromogenes.

B-40
Bayer CropScience
Glufosinate ammonium herbicide tolerant

(Aventis
soybean produced by inserting a modified

CropScience(AgrEvo))
phosphinothricin acetyltransferase (PAT)

encoding gene from the soil bacterium

Streptomyces viridochromogenes.

B-41
DuPont Canada
High oleic acid soybean produced by inserting a

Agricultural Products
second copy of the fatty acid desaturase

(GmFad2-1) encoding gene from soybean, which

resulted in “silencing” of the endogenous host

gene.

B-42
Monsanto Company
Glyphosate tolerant soybean variety produced by

inserting a modified 5-enolpyruvylshikimate-3-

phosphate synthase (EPSPS) encoding gene from

the soil bacterium Agrobacterium tumefaciens.

B-43
Bayer CropScience
Glufosinate ammonium herbicide tolerant

(Aventis
soybean produced by inserting a modified

CropScience(AgrEvo))
phosphinothricin acetyltransferase (PAT)

encoding gene from the soil bacterium

Streptomyces viridochromogenes.

B-44
Monsanto Company
Glyphosate-tolerant soybean produced by

inserting a modified 5-enolpyruvylshikimate-3-

phosphate synthase (EPSPS) encoding aroA

(epsps) gene from Agrobacterium tumefaciens

CP4.

B-45
Agriculture & Agri-Food
Low linolenic acid soybean produced through

Canada
traditional cross-breeding to incorporate the novel

trait from a naturally occurring fanl gene mutant

that was selected for low linolenic acid.

B-46
Bayer CropScience
Glufosinate ammonium herbicide tolerant

(Aventis
soybean produced by inserting a modified

CropScience(AgrEvo))
phosphinothricin acetyltransferase (PAT)

encoding gene from the soil bacterium

Streptomyces hygroscopicus.

B-47
Monsanto Company
Insect resistant cotton derived by transformation

of the DP50B parent variety, which contained

event 531 (expressing Cry1Ac protein), with

purified plasmid DNA containing the cry2Ab

gene from B. thuringiensis subsp. kurstaki.

B-48
DuPont Canada
Introduction of a variant form of acetolactate

Agricultural Products
synthase (ALS).

B-49
DOW AgroSciences LLC
Insect-resistant cotton produced by inserting the

cry1F gene from Bacillus thuringiensis var.

aizawai. The PAT encoding gene from

Streptomyces viridochromogenes was introduced

as a selectable marker.

B-50
DOW AgroSciences LLC
Insect-resistant cotton produced by inserting the

cry1Ac gene from Bacillus thuringiensis subsp.

kurstaki. The PAT encoding gene from

Streptomyces viridochromogenes was introduced

as a selectable marker.

B-51
Calgene Inc.
Insect-resistant and bromoxynil herbicide tolerant

cotton produced by inserting the cry1Ac gene

from Bacillus thuringiensis and a nitrilase

encoding gene from Klebsiella pneumoniae.

B-52
Calgene Inc.
Bromoxynil herbicide tolerant cotton produced by

inserting a nitrilase encoding gene from

Klebsiella pneumoniae.

B-53
Syngenta Seeds, Inc.
Insect-resistant cotton produced by inserting the

vip3A(a) gene from Bacillus thuringiensis AB88.

The APH4 encoding gene from E. coli was

introduced as a selectable marker.

B-54
DOW AgroSciences LLC
WideStrike ™, a stacked insect-resistant cotton

derived from conventional cross-breeding of

parental lines 3006-210-23 (OECD identifier:

DAS-21Ø23-5) and 281-24-236 (OECD

identifier: DAS-24236-5).

B-55
DOW AgroSciences LLC
Stacked insect-resistant and glyphosate-tolerant

and Pioneer Hi-Bred
cotton derived from conventional cross-breeding

International Inc.
of WideStrike cotton (OECD identifier: DAS-

21Ø23-5 × DAS-24236-5) with MON88913,

known as RoundupReady Flex (OECD identifier:

MON-88913-8).

B-56
DOW AgroSciences LLC
WideStrike ™/Roundup Ready ® cotton, a stacked

insect-resistant and glyphosate-tolerant cotton

derived from conventional cross-breeding of

WideStrike cotton (OECD identifier: DAS-

21Ø23-5 × DAS-24236-5) with MON1445

(OECD identifier: MON-Ø1445-2).

B-57
Bayer CropScience
Glufosinate ammonium herbicide tolerant cotton

(Aventis
produced by inserting a modified

CropScience(AgrEvo))
phosphinothricin acetyltransferase (PAT)

encoding gene from the soil bacterium

Streptomyces hygroscopicus.

B-58
Bayer CropScience
Stacked herbicide tolerant and insect resistant

(Aventis
cotton combining tolerance to glufosinate

CropScience(AgrEvo))
ammonium herbicide from LLCotton25 (OECD

identifier: ACS-GHØØ1-3) with resistance to

insects from MON15985 (OECD identifier:

MON-15985-7)

B-59
Monsanto Company
Glyphosate herbicide tolerant cotton produced by

inserting a naturally glyphosate tolerant form of

the enzyme 5-enolpyruvyl shikimate-3-phosphate

synthase (EPSPS) from A. tumefaciens strain

CP4.

B-60
Monsanto Company
Stacked insect resistant and glyphosate tolerant

cotton produced by conventional cross-breeding

of the parental lines MON88913 (OECD

identifier: MON-88913-8) and 15985 (OECD

identifier: MON-15985-7). Glyphosate tolerance

is derived from MON88913 which contains two

genes encoding the enzyme 5-

enolypyruvylshikimate-3-phosphate synthase

(EPSPS) from the CP4 strain of Agrobacterium

tumefaciens. Insect resistance is derived

MON15985 which was produced by

transformation of the DP50B parent variety,

which contained event 531 (expressing Cry1Ac

protein), with purified plasmid DNA containing

the cry2Ab gene from B. thuringiensis subsp.

kurstaki.

B-61
Monsanto Company
Stacked insect resistant and herbicide tolerant

cotton derived from conventional cross-breeding

of the parental lines 15985 (OECD identifier:

MON-15985-7) and MON1445 (OECD identifier:

MON-Ø1445-2).

B-62
Monsanto Company
Insect-resistant cotton produced by inserting the

cry1Ac gene from Bacillus thuringiensis subsp.

kurstaki HD-73 (B.t.k.).

B-63
Monsanto Company
Glyphosate herbicide tolerant cotton produced by

inserting two genes encoding the enzyme 5-

enolypyruvylshikimate-3-phosphate synthase

(EPSPS) from the CP4 strain of Agrobacterium

tumefaciens.

B-64
Monsanto Company
Stacked insect resistant and herbicide tolerant

cotton derived from conventional cross-breeding

of the parental lines MON531 (OECD identifier:

MON-ØØ531-6) and MON1445 (OECD

identifier: MON-Ø1445-2).

B-65
Bayer BioScience N.V.,
Genetic elements which confer the phenotype

Technologiepark 38
insect resistant and glufosinate ammonium

B-9052 Gent
herbicide tolerance:

Belgium
cry1: Coding sequence of cry gene from Bacillus

thuringiensis that confers the insect resistance

trait.

bar: Coding sequence of the phosphinothricin

acetyltransferase gene (bar) from Streptomyces

hygroscopicus that confers the herbicide

resistance trait.

B-66
Bayer BioScience N.V.,
Genetic elements which confer the phenotype

Technologiepark 38
insect resistant and glufosinate ammonium

B-9052 Gent
herbicide tolerance:

Belgium
cry2: Coding sequence of cry gene from Bacillus

thuringiensis that confers the insect resistance

trait.

bar: Coding sequence of the phosphinothricin

acetyltransferase gene (bar) from Streptomyces

hygroscopicus that confers the herbicide

resistance trait.

B-67
Bayer BioScience N.V.,
Genetic elements which confer the phenotype

Technologiepark 38
insect resistant and glufosinate ammonium

B-9052 Gent
herbicide tolerance:

Belgium
cry2: Coding sequence of cry gene from Bacillus

thuringiensis that confers the insect resistance

trait.

bar: Coding sequence of the phosphinothricin

acetyltransferase gene (bar) from Streptomyces

hygroscopicus that confers the herbicide

resistance trait.

B-68
Bayer BioScience N.V.,
cry1: Coding sequence of cry gene from Bacillus

Technologiepark 38

thuringiensis that confers the insect resistance

B-9052 Gent
trait.

Belgium
bar: Coding sequence of the phosphinothricin

acetyltransferase gene (bar) from Streptomyces

hygroscopicus that confers the herbicide

resistance trait.

B-69
Bayer BioScience N.V.,
2mepsps: Coding sequence of 2mepsps from

Technologiepark 38
maize that confers the glyphosate herbicide

B-9052 Gent
resistance trait.

Belgium

B-70
BASF Inc.
Tolerance to imidazolinone herbicides by

selection of a naturally occurring mutant.

B-71
BASF Inc.
Selection for a mutagenized version of the

enzyme acetohydroxyacid synthase (AHAS), also

known as acetolactate synthase (ALS) or

acetolactate pyruvate-lyase.

B-72
University of
A variant form of acetolactate synthase (ALS)

Saskatchewan, Crop Dev.
was obtained from a chlorsulfuron tolerant line of

Centre

A. thaliana and used to transform flax.

B-73
Monsanto Company
Resistance to lepidopteran pests through the

introduction of the cry1Ac gene from Bacillus

thuringiensis subsp. Kurstaki.

B-74
Monsanto Company
Introduction of a gene sequence encoding the

enzyme 1-amino-cyclopropane-1-carboxylic acid

deaminase (ACCd) that metabolizes the precursor

of the fruit ripening hormone ethylene.

B-75
DNA Plant Technology
Delayed ripening tomatoes produced by inserting

Corporation
an additional copy of a truncated gene encoding

1-aminocyclopropane-1-carboxyllic acid (ACC)

synthase, which resulted in downregulation of the

endogenous ACC synthase and reduced ethylene

accumulation.

B-76
Agritope Inc.
Introduction of a gene sequence encoding the

enzyme S-adenosylmethionine hydrolase that

metabolizes the precursor of the fruit ripening

hormone ethylene

B-77
Zeneca Seeds
Delayed softening tomatoes produced by inserting

a truncated version of the polygalacturonase (PG)

encoding gene in the sense or anti-sense

orientation in order to reduce expression of the

endogenous PG gene, and thus reduce pectin

degradation.

B-78
Calgene Inc.
Delayed softening tomatoes produced by inserting

an additional copy of the polygalacturonase (PG)

encoding gene in the anti-sense orientation in

order to reduce expression of the endogenous PG

gene and thus reduce pectin degradation.

B-79
Monsanto Company and
Glyphosate herbicide tolerant alfalfa (lucerne)

Forage Genetics
produced by inserting a gene encoding the

International
enzyme 5-enolypyruvylshikimate-3-phosphate

synthase (EPSPS) from the CP4 strain of

Agrobacterium tumefaciens.

B-80
Societe National
Tolerance to the herbicides bromoxynil and

d'Exploitation des Tabacs
ioxynil by incorporation of the nitrilase gene from

et Allumettes

Klebsiella pneumoniae.

B-81
Vector Tobacco Inc.
Reduced nicotine content through introduction of

a second copy of the tobacco quinolinic acid

phosphoribosyltransferase (QTPase) in the

antisense orientation. The NPTII encoding gene

from E. coli was introduced as a selectable

marker to identify transformants.

B-82
BASF Inc.
Tolerance to the imidazolinone herbicide,

imazethapyr, induced by chemical mutagenesis of

the acetolactate synthase (ALS) enzyme using

ethyl methanesulfonate (EMS).

B-83
BASF Inc.
Tolerance to imidazolinone herbicides induced by

chemical mutagenesis of the acetolactate synthase

(ALS) enzyme using sodium azide.

B-84
Aventis CropScience
Glufosinate ammonium herbicide tolerant rice

produced by inserting a modified

phosphinothricin acetyltransferase (PAT)

encoding gene from the soil bacterium

Streptomyces hygroscopicus).

B-85
Bayer CropScience
Glufosinate ammonium herbicide tolerant rice

(Aventis
produced by inserting a modified

CropScience(AgrEvo))
phosphinothricin acetyltransferase (PAT)

encoding gene from the soil bacterium

Streptomyces hygroscopicus).

B-86
BASF Inc.
Tolerance to the imidazolinone herbicide,

imazethapyr, induced by chemical mutagenesis of

the acetolactate synthase (ALS) enzyme using

ethyl methanesulfonate (EMS).

B-87
Monsanto Company
Colorado potato beetle resistant potatoes

produced by inserting the cry3A gene from

Bacillus thuringiensis (subsp. Tenebrionis).

B-88
Monsanto Company
Colorado potato beetle resistant potatoes

produced by inserting the cry3A gene from

Bacillus thuringiensis (subsp. Tenebrionis).

B-89
Monsanto Company
Colorado potato beetle and potato virus Y (PVY)

resistant potatoes produced by inserting the cry3A

gene from Bacillus thuringiensis (subsp.

Tenebrionis) and the coat protein encoding gene

from PVY.

B-90
Monsanto Company
Colorado potato beetle and potato leafroll virus

(PLRV) resistant potatoes produced by inserting

the cry3A gene from Bacillus thuringiensis

(subsp. Tenebrionis) and the replicase encoding

gene from PLRV.

B-91
BASF Plant Science
a) A gene containing the coding region of potato

GmbH
gbss in antisense orientation relative to the

promoter, flanked by the gbss promoter from

Solanum tuberosum and the polyadenylation

sequence from Agrobacterium tumefaciens

nopaline synthase gene has been inserted into

potato variety Seresta (lines AM02-1003, AM01-

1005, AM02-1012) and Kuras (line AM02-1017)

thus reducing the amount of amylose in the starch

fraction. An ahas gene (acetohydroxyacid

synthase) from Arabidopsis thaliana flanked by

the nos gene promoter and the octopine synthase

polyadenylation sequence from Agrobacterium

tumefaciens serves as selectable marker gene

conferring tolerance to Imazamox.

b) AM99-1089 serves as a reference line. The

inserted gene consists of the potato gbss (granule

bound starch synthase) promoter, the coding

region of potato gbss in antisense orientation and

the polyadenylation sequence from

Agrobacterium tumefaciens nopaline synthase

gene thus reducing the amount of amylose in the

starch fraction. In addition the neomycin

phosphotransferase gene (nptII) connected to the

Agrobacterium tumefaciens nopaline synthase

promoter and g7 polyadenylation sequence from

Agrobacterium tumefaciens has been inserted as

selectable marker gene conferring resistance to

kanamycin.

c) In potato line AM99-2003 a gene consisting of

gbss promoter from Solanum tuberosum, the

coding region fragments of be1 and be2 (starch-

branching enzyme) in tandem and antisense

orientation relative to the promoter and the nos

polyadenylation sequence from Agrobacterium

tumefaciens have been inserted into potato variety

Dinamo thus reducing the amount of amylopectin

in the starch fraction of the tuber. In addition the

neomycin phosphotransferase gene (nptII)

connected to the Agrobacterium tumefaciens

nopaline synthase promoter and g7

polyadenylation sequence from Agrobacterium

tumefaciens has been inserted as selectable

marker gene conferring resistance to kanamycin.

B-92
BASF Plant Science
In potato event EH92-527-1 a gene consisting of a

GmbH
potato gbss (granule bound starch synthase)

promoter, a fragment of the coding region of

potato gbss in antisense orientation relative to the

promoter and the polyadenylation sequence from

Agrobacterium tumefaciens nopaline synthase

gene (gene construct pHoxwG) have been

inserted into potato variety Prevalent thus

reducing the amount of amylose in the starch

fraction. In addition the neomycin

phosphotransferase gene (nptII) connected to the

Agrobacterium tumefaciens nopaline synthase

promoter and polyadenylation signal has been

inserted as selectable marker gene conferring

resistance to kanamycin.

B-93
BASF Inc.
Selection for a mutagenized version of the

enzyme acetohydroxyacid synthase (AHAS), also

known as acetolactate synthase (ALS) or

acetolactate pyruvate-lyase.

B-94
BASF Inc.
Selection for a mutagenized version of the

enzyme acetohydroxyacid synthase (AHAS), also

known as acetolactate synthase (ALS) or

acetolactate pyruvate-lyase.

B-95
BASF Inc.
Selection for a mutagenized version of the

enzyme acetohydroxyacid synthase (AHAS), also

known as acetolactate synthase (ALS) or

acetolactate pyruvate-lyase.

B-96
Monsanto Company
Glyphosate tolerant wheat variety produced by

inserting a modified 5-enolpyruvylshikimate-3-

phosphate synthase (EPSPS) encoding gene from

the soil bacterium Agrobacterium tumefaciens,

strain CP4.

B-97
Cyanamid Crop
Selection for a mutagenized version of the

Protection
enzyme acetohydroxyacid synthase (AHAS), also

known as acetolactate synthase (ALS) or

acetolactate pyruvate-lyase.

B-98
BASF Inc.

B-99
BASF Inc.
Tolerance to imidazolinone herbicides

B-100
BASF Inc.
Selection for a mutagenized version of the

enzyme acetohydroxyacid synthase (AHAS), also

known as acetolactate synthase (ALS) or

acetolactate pyruvate-lyase.

B-101
Syngenta Seeds, Inc.,
Insect-resistant maize produced by inserting the

Novartis, Mycogen
cry1Ab gene from Bacillus thuringiensis subsp.

kurstaki. The genetic modification affords

resistance to attack by the European corn borer

(ECB).

B-102
Pioneer Hi-Bred
Selection of somaclonal variants by culture of

International Inc.
embryos on imidazolinone containing media.

B-103
Pioneer Hi-Bred
Male-sterile and glufosinate ammonium herbicide

International Inc.
tolerant maize produced by inserting genes

encoding DNA adenine methylase and

phosphinothricin acetyltransferase (PAT) from

Escherichia coli and Streptomyces

viridochromogenes, respectively.

B-104
Bayer CropScience
Stacked insect resistant and herbicide tolerant

(Aventis
corn hybrid derived from conventional cross-

CropScience(AgrEvo))
breeding of the parental lines T25 (OECD

identifier: ACS-ZMØØ3-2) and MON810 (OECD

identifier: MON-ØØ81Ø-6).

B-105
Dekalb Genetics
Glufosinate ammonium herbicide tolerant maize

Corporation
produced by inserting the gene encoding

phosphinothricin acetyltransferase (PAT) from

Streptomyces hygroscopicus.

B-106
Syngenta Seeds, Inc.
Insect-resistant and herbicide tolerant maize

produced by inserting the cry1Ab gene from

Bacillus thuringiensis subsp. kurstaki, and the

phosphinothricin N-acetyltransferase (PAT)

encoding gene from S. viridochromogenes.

B-107
Aventis CropScience
Insect-resistant and glufosinate ammonium

herbicide tolerant maize developed by inserting

genes encoding Cry9C protein from Bacillus

thuringiensis subsp tolworthi and

phosphinothricin acetyltransferase (PAT) from

Streptomyces hygroscopicus.

B-108
DOW AgroSciences LLC
Lepidopteran insect resistant and glufosinate

ammonium herbicide-tolerant maize variety

produced by inserting the cry1F gene from

Bacillus thuringiensis var aizawai and the

phosphinothricin acetyltransferase (PAT) from

Streptomyces hygroscopicus.

B-109
DOW AgroSciences LLC
Corn rootworm-resistant maize produced by

and Pioneer Hi-Bred
inserting the cry34Ab1 and cry35Ab1 genes from

International Inc.

Bacillus thuringiensis strain PS149B1. The PAT

encoding gene from Streptomyces

viridochromogenes was introduced as a selectable

marker.

B-110
DOW AgroSciences LLC
Stacked insect resistant and herbicide tolerant

and Pioneer Hi-Bred
maize produced by conventional cross breeding of

International Inc.
parental lines DAS-59122-7 (OECD unique

identifier: DAS-59122-7) with NK603 (OECD

unique identifier: MON-ØØ6Ø3-6). Corn

rootworm-resistance is derived from DAS-59122-

7 which contains the cry34Ab1 and cry35Ab1

genes from Bacillus thuringiensis strain PS149B1.

Tolerance to glyphosate herbcicide is derived

from NK603.

B-111
DOW AgroSciences LLC
Stacked insect resistant and herbicide tolerant

and Pioneer Hi-Bred
maize produced by conventional cross breeding of

International Inc.
parental lines DAS-59122-7 (OECD unique

identifier: DAS-59122-7) and TC1507 (OECD

unique identifier: DAS-Ø15Ø7-1) with NK603

(OECD unique identifier: MON-ØØ6Ø3-6). Corn

rootworm-resistance is derived from DAS-59122-

7 which contains the cry34Ab1 and cry35Ab1

genes from Bacillus thuringiensis strain PS149B1.

Lepidopteran resistance and toleraance to

glufosinate ammonium herbicide is derived from

TC1507. Tolerance to glyphosate herbcicide is

derived from NK603.

B-112
DOW AgroSciences LLC
Stacked insect resistant and herbicide tolerant

corn hybrid derived from conventional cross-

breeding of the parental lines 1507 (OECD

identifier: DAS-Ø15Ø7-1) and NK603 (OECD

identifier: MON-ØØ6Ø3-6).

B-113
Dekalb Genetics
Insect-resistant and glufosinate ammonium

Corporation
herbicide tolerant maize developed by inserting

genes encoding Cry1AC protein from Bacillus

thuringiensis subsp kurstaki and phosphinothricin

acetyltransferase (PAT) from Streptomyces

hygroscopicus

B-114
BASF Inc.
Somaclonal variants with a modified acetyl-CoA-

carboxylase (ACCase) were selected by culture of

embryos on sethoxydim enriched medium.

B-115
Syngenta Seeds, Inc.
Tolerance to the imidazolinone herbicide,

(formerly Zeneca Seeds)
imazethapyr, induced by chemical mutagenesis of

the acetolactate synthase (ALS) enzyme using

ethyl methanesulfonate (EMS).

B-116
Monsanto Company
Introduction, by particle bombardment, of a

modified 5-enolpyruvyl shikimate-3-phosphate

synthase (EPSPS), an enzyme involved in the

shikimate biochemical pathway for the production

of the aromatic amino acids.

B-117
Pioneer Hi-Bred
Tolerance to the imidazolinone herbicide,

International Inc.
imazethapyr, was obtained by in vitro selection of

somaclonal variants.

B-118
Monsanto Company
Altered amino acid composition, specifically

elevated levels of lysine, through the introduction

of the cordapA gene, derived from

Corynebacterium glutamicum, encoding the

enzyme dihydrodipicolinate synthase (cDHDPS).

B-119
Syngenta Seeds, Inc.
Corn rootworm resistant maize produced by

transformation with a modified cry3A gene. The

phosphomannose isomerase gene from E. coli was

used as a selectable marker.

B-120
Monsanto Company
Insect-resistant maize produced by inserting the

cry1Ab gene from Bacillus thuringiensis subsp.

kurstaki. The genetic modification affords

resistance to attack by the European corn borer

(ECB).

B-121
Monsanto Company
Insect-resistant and glyphosate herbicide tolerant

maize produced by inserting the genes encoding

the Cry1Ab protein from Bacillus thuringiensis

and the 5-enolpyruvylshikimate-3-phosphate

synthase (EPSPS) from A. tumefaciens strain

CP4.

B-122
Pioneer Hi-Bred
Resistance to European corn borer (Ostrinia

International Inc.

nubilalis) by introduction of a synthetic cry1Ab

gene. Glyphosate resistance via introduction of

the bacterial version of a plant enzyme, 5-

enolpyruvyl shikimate-3-phosphate synthase

(EPSPS).

B-123
Monsanto Company
Insect-resistant maize produced by inserting a

truncated form of the cry1Ab gene from Bacillus

thuringiensis subsp. kurstaki HD-1. The genetic

modification affords resistance to attack by the

European corn borer (ECB).

B-124
Monsanto Company
Stacked insect resistant and glyphosate tolerant

maize derived from conventional cross-breeding

of the parental lines MON810 (OECD identifier:

MON-ØØ81Ø-6) and MON88017 (OECD

identifier: MON-88Ø17-3). European corn borer

(ECB) resistance is derived from a truncated form

of the cry1Ab gene from Bacillus thuringiensis

subsp. kurstaki HD-1 present in MON810. Corn

rootworm resistance is derived from the cry3Bb1

gene from Bacillus thuringiensis subspecies

kumamotoensis strain EG4691 present in

MON88017. Glyphosate tolerance is derived from

a 5-enolpyruvylshikimate-3-phosphate synthase

(EPSPS) encoding gene from Agrobacterium

tumefaciens strain CP4 present in MON88017.

B-125
Monsanto Company
Introduction, by particle bombardment, of

glyphosate oxidase (GOX) and a modified 5-

enolpyruvyl shikimate-3-phosphate synthase

(EPSPS), an enzyme involved in the shikimate

biochemical pathway for the production of the

aromatic amino acids.

B-126
Monsanto Company
Corn root worm resistant maize produced by

inserting the cry3Bb1 gene from Bacillus

thuringiensis subsp. kumamotoensis.

B-127
Monsanto Company
Corn rootworm-resistant maize produced by

inserting the cry3Bb1 gene from Bacillus

thuringiensis subspecies kumamotoensis strain

EG4691. Glyphosate tolerance derived by

inserting a 5-enolpyruvylshikimate-3-phosphate

synthase (EPSPS) encoding gene from

Agrobacterium tumefaciens strain CP4.

B-128
Monsanto Company
Stacked insect resistant and herbicide tolerant

corn hybrid derived from conventional cross-

breeding of the parental lines NK603 (OECD

identifier: MON-ØØ6Ø3-6) and MON810

(OECD identifier: MON-ØØ81Ø-6).

B-129
Monsanto Company
Stacked insect resistant and enhanced lysine

content maize derived from conventional cross-

breeding of the parental lines MON810 (OECD

identifier: MON-ØØ81Ø-6) and LY038 (OECD

identifier: REN-ØØØ38-3).

B-130
Monsanto Company
Stacked insect resistant and herbicide tolerant

corn hybrid derived from conventional cross-

breeding of the parental lines MON863 (OECD

identifier: MON-ØØ863-5) and NK603 (OECD

identifier: MON-ØØ6Ø3-6).

B-131
Monsanto Company
Stacked insect resistant corn hybrid derived from

conventional cross-breeding of the parental lines

MON863 (OECD identifier: MON-ØØ863-5) and

MON810 (OECD identifier: MON-ØØ81Ø-6)

B-132
Monsanto Company
Stacked insect resistant and herbicide tolerant

corn hybrid derived from conventional cross-

breeding of the stacked hybrid MON-ØØ863-5 ×

MON-ØØ81Ø-6 and NK603 (OECD

identifier: MON-ØØ6Ø3-6).

B-133
Monsanto Company
Stacked insect resistant and herbicide tolerant

corn hybrid derived from conventional cross-

breeding of the parental lines GA21 (OECD

identifider: MON-ØØØ21-9) and MON810

(OECD identifier: MON-ØØ81Ø-6).

B-134
Bayer CropScience
Male sterility caused by expression of the barnase

(Aventis
ribonuclease gene from Bacillus

CropScience(AgrEvo))

amyloliquefaciens; PPT resistance was via PPT-

acetyltransferase (PAT).

B-135
Bayer CropScience
Male sterility caused by expression of the barnase

(Aventis
ribonuclease gene from Bacillus

CropScience(AgrEvo))

amyloliquefaciens; PPT resistance was via PPT-

acetyltransferase (PAT).

B-136
Monsanto Company
Introduction, by particle bombardment, of a

modified 5-enolpyruvyl shikimate-3-phosphate

synthase (EPSPS), an enzyme involved in the

shikimate biochemical pathway for the production

of the aromatic amino acids.

B-137
Syngenta Seeds, Inc.
Stacked insect resistant and herbicide tolerant

maize produced by conventional cross breeding of

parental lines BT11 (OECD unique identifier:

SYN-BTØ11-1) and GA21 (OECD unique

identifier: MON-ØØØ21-9).

B-138
Bayer CropScience
Glufosinate herbicide tolerant maize produced by

(Aventis
inserting the phosphinothricin N-acetyltransferase

CropScience(AgrEvo))
(PAT) encoding gene from the aerobic

actinomycete Streptomyces viridochromogenes.

B-139
Mycogen (c/o Dow
Insect-resistant and glufosinate ammonium

AgroSciences); Pioneer
herbicide tolerant maize produced by inserting the

(c/o Dupont)
cry1F gene from Bacillus thuringiensis var.

aizawai and the phosphinothricin N-

acetyltransferase encoding gene from

Streptomyces viridochromogenes.

B-140
DOW AgroSciences LLC
Stacked insect resistant and herbicide tolerant

and Pioneer Hi-Bred
maize produced by conventional cross breeding of

International Inc.
parental lines TC1507 (OECD unique identifier:

DAS-Ø15Ø7-1) with DAS-59122-7 (OECD

unique identifier: DAS-59122-7). Resistance to

lepidopteran insects is derived from TC1507 due

the presence of the cry1F gene from Bacillus

thuringiensis var. aizawai. Corn rootworm-

resistance is derived from DAS-59122-7 which

contains the cry34Ab1 and cry35Ab1 genes from

Bacillus thuringiensis strain PS149B1. Tolerance

to glufosinate ammonium herbcicide is derived

from TC1507 from the phosphinothricin N-

acetyltransferase encoding gene from

Streptomyces viridochromogenes.

B-141
Syngenta Agrisure GT
Glyphosate Herbicide Tolerance

B-142
Syngenta Agrisure
Cry1Ab Corn borer protection

GT/CB YieldGard
Glyphosate Herbicide Tolerance

Liberty Link

B-143
MonsantoYieldGard
Cry1Ab corn borer resistance

Roundup Ready
Glyphosate Herbicide Tolerance

B-144
Monsanto Agrar
A full description of the genetic elements in MON

Deutschland GmbH
89034, including the approximate size, source and

function is provided in Table 1.

Table 1. Summary of the genetic elements

inserted in MON 89034

B1-Left Border*: 239 bp DNA region from the

B?Left Border region remaining after integration

Pp2-e35S: Modified promoter and leader for the

cauliflower mosaic virus (CaMV) 35S RNA

containing the duplicated enhancer region

L3-Cab: 5′ untranslated leader of the wheat

chlorophyll a/b?binding protein

I4-Ract1: Intron from the rice actin gene

CS5-cry1A.105: Coding sequence for the

Bacillus thuringiensis Cry1A.105 protein

T6-Hsp17: 3′ transcript termination sequence for

wheat heat shock protein 17.3, which ends

transcription and directs polyadenylation

P-FMV: Figwort Mosaic Virus 35S promoter

I-Hsp70: First intron from the maize heat shock

protein 70 gene

TS7-SSU-CTP: DNA region containing the

targeting sequence for the transit peptide region

of maize ribulose 1,5-bisphosphate carboxylase

small subunit and the first intron

CS-cry2Ab2: Coding sequence for a Cry2Ab2

protein from Bacillus thuringiensis. This coding

sequence uses a modified codon usage.

T-nos: 3′ transcript termination sequence of the

nopaline synthase (nos) coding sequence from

Agrobacterium tumefaciens which terminates

transcription and directs polyadenylation

B-Left Border: 230 bp DNA region from the B-

Left Border region remaining after integration

*Analyses of the MON 89034 insert sequence

revealed that the e35S promoter that regulates

expression of the cry1A.105 coding sequence was

modified: the Right Border sequence present in

PV-ZMIR245 was replaced by the Left Border

sequence. It is likely that this modification is the

result of a crossover recombination event that

occurred prior to the DNA being inserted into the

genome.

B-145
Monsanto Agrar

Deutschland GmbH

B-146
Monsanto Agrar

Deutschland GmbH

B-147
Pioneer Hi-Bred Seeds
98140 maize has been genetically modified by

Agro SRL
insertion of the glyphosate-N-acetyltransferase

(gat4621) gene and a modified maize acetolactate

synthase (zm-hra) gene, along with the necessary

regulatory elements for gene expression in the

maize plant.

The gat4621 gene encodes the GAT4621 protein,

which was derived from the soil bacterium

Bacillus licheniformis, and confers tolerance to

herbicides containing glyphosate. The zm-hra

gene encodes the ZM-HRA protein and confers

tolerance to a range of ALS-inhibiting herbicides

such as sulfonylureas.

B-148
Syngenta Seeds SA
Regulatory sequences:

Promoter sequences derived from maize. The

function of these sequences is to control

expression of the insect resistance gene.

Insect resistance gene:

cry1Ab gene derived form Bacillus thuringiensis.

The function of the product of this gene is to

confer resistance to certain lepidopteran pests.

NOS terminator:

Terminator sequence of the nopaline synthase

gene, isolated from Agrobacterium tumefaciens.

The function of this sequence is to signal the

termination of the insect resistance gene

expression.

ZmUbilntron:

Promoter from a maize ubiquitin gene together

with the first intron of the gene. The function of

these sequences is to control and enhance

expression of the Phosphomannose Isomerase

(pmi) gene.

pmi:

Coding sequence of the Phosphomannose

Isomerase (pmi) gene isolated from Escherichia

coli. The function of this gene product is as a

selectable marker for the transformation, as it

allows positive selection of transformed cells

growing on mannose.

NOS terminator:

Termination sequence of the nopaline synthase

gene, isolated from Agrobacterium tumefaciens.

The function of this sequence is to signal the

termination of the marker gene (pmi) expression.

B-149
Delta and Pine Land
Bollgard ®, RoundupReady ®

company

B-150

B-151
Monsanto Company

B-152
Monsanto Company

B-153

B-154
Illinois Foundation Seeds

B-155

TABLE 6

No.
Commercial name
Plant
Company

4-1
Roundup Ready ®

Beta vulgaris (Sugar Beet)
Monsanto Company

4-2
InVigor ®

Brassica napus (Argentine Canola)
BayerCropScience

4-3
Liberty Link ®

Brassica napus (Argentine Canola)
BayerCropScience

4-4
Roundup Ready ®

Brassica napus (Canola)
Monsanto Company

4-5
Clearfield ®
Canola
BASF Corporation

4-6
Optimum ™ GAT ™

Glycine max

Pioneer Hi-Bred International, Inc

L. (Soybean)

4-7
Roundup Ready ®

Glycine max

Monsanto Company

L. (Soybean)

4-8
Roundup

Glycine max

Monsanto Company

RReady2Yield ™
L. (Soybean)

4-9
STS ®

Glycine max

DuPont

L. (Soybean)

4-10
YIELD GARD ®

Glycine max

Monsanto Company

L. (Soybean)

4-11
AFD ®

Gossypium hirsutum L. (Cotton)
BayerCropScience

4-12
Bollgard II ®
Gossypium hirsutum
Monsanto Company

L. (Cotton)

4-13
Bollgard ®

Gossypium hirsutum

Monsanto Company

L. (Cotton)

4-14
FiberMax ®

Gossypium hirsutum

BayerCropScience

L. (Cotton)

4-15
Liberty Link ®

Gossypium hirsutum

BayerCropScience

L. (Cotton)

4-16
Nucotn 33B

Gossypium hirsutum

Delta Pine and Land

L. (Cotton)

4-17
Nucotn 35B

Gossypium hirsutum

Delta Pine and Land

L. (Cotton)

4-18
Nucotn ®

Gossypium hirsutum

Delta Pine and Land

L. (Cotton)

4-19
PhytoGen ™

Gossypium hirsutum

PhytoGen

L. (Cotton)
Seed Company, Dow AgroSciences LLC

4-20
Roundup Ready

Gossypium hirsutum

Monsanto Company

Flex ®
L. (Cotton)

4-21
Roundup Ready ®

Gossypium hirsutum

Monsanto Company

L. (Cotton)

4-22
Widestrike ™

Gossypium hirsutum

Dow AgroSciences

L. (Cotton)
LLC

4-23
YIELD GARD ®

Gossypium hirsutum

Monsanto Company

L. (Cotton)

4-24
Roundup Ready ®

Medicago

Monsanto Company

sativa (Alfalfa)

4-25
Clearfield ®

Oryza sativa (Rice)
BASF Corporation

4-26
NewLeaf ®

Solanum tuberosum

Monsanto Company

L. (Potato)

4-27
NewLeaf ® plus

Solanum tuberosum

Monsanto Company

L. (Potato)

4-28
Protecta ®

Solanum tuberosum

?

L. (Potato)

4-29
Clearfield ®
Sunflower
BASF Corporation

4-30
Roundup Ready ®

Triticum

Monsanto Company

aestivum (Wheat)

4-31
Clearfield ®
Wheat
BASF Corporation

4-32
Agrisure ® (Family)

Zea mays L. (Maize)
Syngenta Seeds, Inc.

4-33
BiteGard ®

Zea mays L. (Maize)
Novartis Seeds

4-34
Bt-Xtra ®

Zea mays L. (Maize)
DEKALB Genetics

Corporation

4-35
Clearfield ®

Zea mays L. (Maize)
BASF Corporation

4-36
Herculex ® (Family)

Zea mays L. (Maize)
Dow AgroSciences

LLC

4-37
IMI ®

Zea mays L. (Maize)
DuPont

4-38
KnockOut ®

Zea mays L. (Maize)
Syngenta Seeds, Inc.

4-39
Mavera ®

Zea mays L. (Maize)
Renessen LLC

4-40
NatureGard ®

Zea mays L. (Maize)
Mycogen

4-41
Roundup Ready ®

Zea mays L. (Maize)
Monsanto Company

4-42
Roundup Ready ® 2

Zea mays L. (Maize)
Monsanto Company

4-43
SmartStax

Zea mays L. (Maize)
Monsanto Company

4-44
StarLink ®

Zea mays L. (Maize)
Aventis CropScience

->Bayer CropScience

4-45
STS ®

Zea mays L. (Maize)
DuPont

4-46
YIELD GARD ®

Zea mays L. (Maize)
Monsanto Company

4-47
YieldGard ® Plus

Zea mays L. (Maize)
Monsanto Company

4-48
YieldGard ®

Zea mays L. (Maize)
Monsanto Company

Rootworm

4-49
YieldGard ® VT

Zea mays L. (Maize)
Monsanto Company

4-50
YieldMaker ™

Zea mays L. (Maize)
DEKALB Genetics

Corporation

No.
Transgenically modified properties
Additional information

4-1
tolerance to glyphosate

4-2
Canola has been genetically modified

to:

Ø express a gene conferring tolerance

to the herbicide glufosinate

ammonium;

Ø introduce a novel hybrid breeding

system for canola, based on

genetically modified male

sterile (MS) and fertility restorer (RF)

lines;

Ø express an antibiotic resistance

gene.

4-3
tolerance to phosphinotricin

4-4
tolerance to glyphosate

4-5
non-GMO, tolerance to imazamox

4-6
tolerance to glyphosate and ALS

herbicides

4-7
tolerance to glyphosate

4-8
tolerance to glyphosate

4-9
tolerance to sulphonylureas

4-10

4-11
lines include eg AFD5062LL,

AFD5064F, AFD 5065B2F, AFD seed

is available in several varieties with

technology incorporated, such as

Bollgard ®, Bollgard II, Roundup

Ready, Roundup Ready Flex and

LibertyLink ® technologies.

4-12
MON 15985 event: Cry2(A)b1;

Cry1A(c)

4-13
Cry 1Ac

4-14

4-15
tolerance to phosphinotricin

4-16
Bt-toxin in Delta Pine lines: CrylAc

4-17
Bt-toxin in Delta Pine lines: CrylAc

4-18
Bt-toxin in Delta Pine lines

4-19
covers varieties containing for

example Roundup Ready flex,

Widestrike,

4-20
tolerance to glyphosate

4-21
tolerance to glyphosate

4-22
Cry1F and Cry1Ac
Monsanto/Dow

4-23

http://www.garstseed.com/GarstClient/Technology/agrisure.aspx

4-24
tolerance to glyphosate

4-25
non-GMO, tolerance to imazamox

4-26
resistant to infection by Potato

Leafroll Virus (PLRV) and to feeding

by the Colorado potato beetle,

Leptinotarsa decemlineata (CPB)

4-27
resistant to infection by Potato
http://www.dowagro.com/phytogen/index.htm

Leafroll Virus (PLRV) and to feeding

by the Colorado potato beetle,

Leptinotarsa decemlineata (CPB)

4-28

4-29
non-GMO, tolerance to imazamox

4-30
tolerance to glyphosate, NK603

4-31
non-GMO, tolerance to imazamox

4-32
includes Agrisure CB/LL (BT 11

event plus tolerance towards

phosphinotricin by GA21 event);

Agrisure CB/LL/RW (Bt 11 event,

modified synthetic Cry3A gene,

tolerance towards phosphinotricin by

GA21 event); Agrisure GT (tolerance

to glyphosate); Agrisure

GT/CB/LL(tolerance to glyphosate

and towards phosphinotricinby GA21

event, Bt 11 event); Agrisure 3000GT

(CB/LL/RW/GT: tolerance to

glyphosate and towards

phosphinotricinby GA21 event, Bt 11

event, modified synthetic Cry3A gene);

Agrisure GT/RW (tolerance to

glyphosate, modified synthetic Cry3A

gene); Agrisure RW (modified

synthetic Cry3A gene); Future Traits

4-33
cry1A(b) gene.

4-34
cry1Ac gene.

4-35
non-GMO, tolerance to imazamox

4-36

4-37
tolerance to imidazolinones

4-38
SYN-EV176-9: cry1A(b) gene.

4-39
high Lysine
http://www.dowagro.com/widestrike/

4-40
cry1A(b) gene.

4-41
tolerance to glyphosate
http://www.starlinkcorn.com/starlinkcorn.htm

4-42
tolerance to glyphosate

4-43
eight gene stack

4-44
Cry9c gene.

4-45
tolerance to sulphonylureas

4-46
Mon810, Cry1Ab1; resistant to corn
http://www.dowagro.com/herculex/about/herculexfamily/

borer

4-47
Mon810 × Mon863, double-stack,

resistant to corn borer and rootworm

4-48
Mon863, Cry3Bb1, resistant to

rootworm

4-49
stacked trait

4-50
include Roundup Ready 2 technology,

YieldGard VT, YieldGard Corn Borer,

YieldGard Rootworm and YieldGard

Plus

EXAMPLES

The invention is illustrated in more detail by the examples below, without being limited thereby.

Example 1

Individually potted transgenic cotton plants with Lepidoptera resistance and herbicide resistance (line DP444 BG/RR) are treated against larvae of the cotton bollworm (Heliothis armigera) in two replications. Application is by spray application with the active compound in question at the stated application rate.

After the desired period of time, the kill in % is determined. 100% means that all caterpillars have been killed; 0% means that none of the caterpillars have been killed.

A considerable improvement in the control of pests compared to the control plants not treated according to the invention is noticeable.

Example 2

Pots containing in each case 5 transgenic maize plants with Lepidoptera resistance and herbicide resistance (line SGI1890 Hx×AGI1847) are treated against the army worm (Spodoptera frugiperda) in 2 replications. Application is by spray application with the active compound in question at the stated application rate.

After the desired period of time, the kill in % is determined. 100% means that all caterpillars have been killed; 0% means that none of the caterpillars have been killed.

A considerable improvement in the control of pests compared to the control plants not treated according to the invention is noticeable.

Example 3

Pots containing in each case 5 transgenic maize plants with herbicide resistance (line FR1064LL X FR2108) are treated against the army worm (Spodoptera frugiperda) in 2 replications. Application is by spray application with the active compound in question at the stated application rate.

After the desired period of time, the kill in % is determined. 100% means that all caterpillars have been killed; 0% means that none of the caterpillars have been killed.

A considerable improvement in the control of pests compared to the control plants not treated according to the invention is noticeable.

Examples 4 to 6

The invention is furthermore also illustrated in more detail by the examples below, without being limited thereby. The spirotetramate mentioned in the tables is the compound I-4.

The activity according to the invention, i.e. the synergistic activity between the transgenic property of the plant and the active compound treatment can be demonstrated using the method of S.R. Colby, Weeds 15 (1967), 20-22. This is based on the following calculation base and assumption (“Colby formula”):

X is the kill rate, expressed in % of the untreated and not transgenically modified control, when employing the active compound A at an application rate of m g/ha or at a concentration of m ppm,
Y is the kill rate, expressed in % of the untreated and not transgenically modified control, when using a transgenic plant and
E is the kill rate, expressed in % of the untreated and not transgenically modified control, when employing active compound A and using a transgenically modified plant, the application rate being m and n g/ha or the concentration being m and n ppm,

then

$E = X + Y - \frac{X \cdot Y}{100} .$

If the actual kill rate (i.e. the activity observed) is higher than the calculated one, the combination of active compound treatment and transgenically modified plant is superadditive in its kill, i.e. a synergistic effect between the active compound treatment and the use of a transgenic plant is present. In this case, the actually observed kill rate must thus be higher than the value calculated using the formula above for the kill rate (E).

In Examples 4 to 6 below, the observed kill rate is higher than the calculated kill rate. Thus, the synergistic activity according to the invention is present. According to the method according to the invention, four days after the treatment a kill of harmful organisms of at least 20%, preferably at least 30%, in particular at least 50%, compared to the control, can be observed. It is also possible to achieve kill results of at least 80 or 90% four days after treatment. Even one day after treatment, the kill of harmful organisms may be at least 20 or 30%.

Example 4

Individually potted transgenic cotton plants having a Lepidoptera resistance and a herbicide resistance (line DP444 BG/RR) which are populated by a mixed population of the cotton aphid (Aphis gossypii) are treated with the active compound in question by spray application.

After a desired period of time, the kill in % is determined by counting the animals. 100% means that all aphids have been killed; 0% means that none of the aphids have been killed.

Compared to the control plants not treated according to the invention, a marked improvement in the control of the pests can be noticed.

Active

compound and line
Concentration
Kill

of the transgenic plant
in ppm
in % after 4^d

Spirotetramate
100
35

DP 444 BG/RR

0

Cry1Ac&cp4 epsps

observed*
calculated**

Spirotetramate + DP 444
100
55
35

BG/RR

*observed according to the invention = activity found

**calculated = activity calculated using the “Colby formula”

Example 5

In two replications, pots with in each case 5 transgenic maize plants having a Coleoptera, Lepidoptera and/or a herbicide resistance (lines LH332RR×LH324BT, HC33CRW×LH287BTCRW, HCL201CRW2RR×LH324 and FR1064LL×FR2108, respectively) are treated against the armyworm (Spodoptera frugiperda). Application is by spray application with the active compound in question at the desired application rate.

After a desired period of time, the kill in % is determined by counting the animals. 100% means that all caterpillars have been killed; 0% means that none of the caterpillars have been killed.

Compared to the control plants not treated according to the invention, a marked improvement in the control of the pests can be noticed.

Active

compound and line of
Concentration
Kill

the transgenic plant
in ppm
in % after 1^d

Spirotetramate
100
0

VSN-BTCRW

0

Cry1Ab&Cry3Bb1

HCL201CRW2RR × LH

0

324

Cry3Bb1&CP4epsps

found*
calculated*

Spirotetramate + VSN-
100
20
0

BTCRW according to

the invention

observed*
calculated**

Spirotetramate +
100
30
0

HCL201CRW2RR × LH

324

*observed according to the invention = activity found

**calculated = activity calculated using the “Colby formula”

Active

compound and line of
Concentration
Kill

the transgenic plant
in ppm
in % after 4^d

Spirotetramate
100
60

VSN-RR Bt

0

Cry1Ab&Cp4 epsps

FR1064LL × FR2108

10

Glufosinate ammonium

resistance

observed*
calculated**

Spirotetramate + VSN-
100
90
60

RR Bt according to

the invention

observed*
calculated**

Spirotetramate + FR
100
80
64

1064LL × FR2108

*observed according to the invention = activity found

**calculated = activity calculated using the “Colby formula”

Example 6

In two replications, pots with in each case 5 transgenic maize plants having a Coleoptera, Lepidoptera and/or a herbicide resistance (lines HC33CRW×LH287BTCRW and TR 47×TR 7322 BT, respectively) are treated against larvae of the armyworm (Spodoptera exigua). Application is by spray application with the active compound in question at the desired application rate.

After a desired period of time, the kill in % is determined by counting the animals. 100% means that all caterpillars have been killed; 0% means that none of the caterpillars have been killed.

Compared to the control plants not treated according to the invention, a marked improvement in the control of the pests can be noticed.

Active

compound and line of
Concentration
Kill

the transgenic plant
in ppm
in % after 4^d

Spirotetramate
100
10

VSN-BTCRW

60

Cry1Ab&Cry3Bb1

VSN-BT

10

Bt MON 810

observed*
calculated**

Spirotetramate + VSN-
100
90
64

BTCRW according to the

invention

observed*
calculated**

Spirotetramate + VSN-
100
30
19

BT

*observed according to the invention = activity found

**calculated = activity calculated using the “Colby formula”

Number	Date	Country	Kind
10 2006 061 621.9	Dec 2006	DE	national
10 2007 009 957.8	Mar 2007	DE	national

METHOD FOR IMPROVED UTILIZATION OF THE PRODUCTION POTENTIAL OF TRANSGENIC PLANTS

Information

Publication Number

Date Filed

Date Published

Inventors

Original Assignees

CPC

US Classifications

International Classifications

Abstract

Description

Claims

Priority Claims (2)

PCT Information