Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a bac-based DNA library: application to the detection of mycobacteria

Information

  • Patent Grant
  • 6492506
  • Patent Number
    6,492,506
  • Date Filed
    Tuesday, September 26, 2000
    24 years ago
  • Date Issued
    Tuesday, December 10, 2002
    21 years ago
Abstract
A method for isolating a polynucleotide of interest that is present in the genome of a first mycobacterium strain and/or is expressed by the first mycobacterium strain, where the polynucleotide of interest is also absent or altered in the genome of a second mycobacterium strain and/or is not expressed in the second mycobacterium. The method includes (a) contacting the genomic DNA of the first mycobacterium strain under hybridizing conditions with the DNA of a least one clone that belongs to a bacterial artificial chromosome (BAC) genomic DNA library of the second mycobacterium strain, and (b) isolating the polynucleotide of interest that does not form a hybrid with the DNA of the second mycobacterium strain. This invention further pertains to a Mycobacterium tuberculosis strain H37Rv genomic DNA library, as well as a Mycobactetium bovis BCG strain Pasteur genomic DNA library, and the recombinant BAC vectors that belong to those genomic DNA libraries. This invention also relates to mycobacterial nucleic acids, and methods and kits for using these nucleic acids to detect mycobacteria in a biological sample.
Description




I. BACKGROUND OF THE INVENTION




The present invention pertains to a method for isolating a polynucleotide of interest that is present in the genome of a mycobacterium strain and/or is expressed by said mycobacterium strain and that is absent or altered in the genome of a different mycobacterium strain and/or is not expressed in said different mycobacterium strain, said method comprising the use of at least one clone belonging to a genomic DNA library of a given mycobaterium strain, said DNA library being cloned in a bacterial artificial chromosome (BAC). The invention concerns also polynucleotides identified by the above method, as well as detection methods for mycobacteria, particularly


Mycobacterium tuberculosis


, and kits using said polynucleotides as primers or probes. Finally, the invention deals with BAC-based mycobacterium DNA libraries used in the method according to the invention and particularly BAC-based


Mycobacterium tuberculosis


and


Mycobacterium bovis


BCG DNA libraries.




Radical measures are required to prevent the grim predictions of the World Health Organisation for the evolution of the global tuberculosis epidemic in the next century becoming a tragic reality. The powerfill combination of genomics and bioinformatics is providing a wealth of information about the etiologic agent,


Mycobacterium tuberculosis


, that will facilitate the conception and development of new therapies. The start point for genome sequencing was the integrated map of the 4.4 Mb circular chromosome of the widely-used, virulent reference strain,


M. tuberculosis


H37Rv and appropriate cosmids were subjected to systematic shotgun sequence analysis at the Sanger Centre.




Cosmid clones (Balasubramanian et al., 1996; Pavelka et al., 1996) have played a crucial role in the


M. tuberculosis


H37Rv genome sequencing project. However, problems such as under-representation of certain regions of the chromosome, unstable inserts and the relatively small insert size complicated the production of a comprehensive set of canonical cosmids representing the entire genome.




II. SUMMARY OF THE INVENTION




In order to avoid the numerous technical constraints encountered in the state of the art, as decribed hereabove, when using genomic mycobacterial DNA libraries constructed in cosmid clones, the inventors have attempted to realize genomic mycobacterial DNA libraries in an alternative type of vectors, namely Bacterial Artificial Chromosome (BAC) vectors.




The success of this approach depended on whether the resulting BAC clones could maintain large mycobacterial DNA inserts. There are various reports describing the successful construction of a BAC library for eucaryotic organisms (Cai et al., 1995; Kim et al., 1996; Misumi et al., 1997; Woo et al., 1994; Zimmer et al., 1997) where inserts up to 725 kb (Zimmer et al., 1997) were cloned and stably maintained in the


E. coli


host strain.




Here, it is shown that, surprisingly, the BAC system can also be used for mycobacterial DNA, as 70% of the clones contained inserts in the size of 25 to 104 kb.




This is the first time that bacterial, and specifically mycobacterial, DNA is cloned in such BAC vectors.




In an attempt to obtain complete coverage of the genome with a minimal overlapping set of clones, a Bacterial Artificial Chromosome (BAC) library of


M. tuberculosis


was constructed, using the vector pBeloBAC11 (Kim et al., 1996) which combines a simple phenotypic screen for recombinant clones with the stable propagation of large inserts (Shizuya et al., 1992). The BAC cloning system is based on the


E. coli


F-factor, whose replication is strictly controlled and thus ensures stable maintenance of large constructs (Willets et al., 1987). BACs have been widely used for cloning of DNA from various eucaryotic species (Cai et al., 1995; Kim et al., 1996; Misumi et al., 1997; Woo et al., 1994; Zimmer et al., 1997). In contrast, to our knowledge this report describes the first attempt to use the BAC system for cloning bacterial DNA.




A central advantage of the BAC cloning system over cosmid vectors used in prior art is that the F-plasmid is present in only one or a maximum of two copies per cell, reducing the potential for recombination between DNA fragments and, more importantly, avoiding the lethal overexpression of cloned bacterial genes. However, the presence of the BAC as just a single copy means that plasmid DNA has to be extracted from a large volume of culture to obtain sufficient DNA for sequencing and it is described here in the examples a simplified protocol to achieve this.




Further, the stability and fidelity of maintenance of the clones in the BAC library represent ideal characteristics for the identification of genomic differences possibly responsible for phenotypic variations in different mycobacterial species.




As it will be shown herein, BACs can be allied with conventional hybridization techniques for refined analyses of genomes and transcriptional activity from different mycobacterial species.




Having established a reliable procedure to screen for genomic polymorphisms, it is now possible to conduct these comparisons on a more systematic basis than in prior art using representative BACs throughout the chromosome and genomic DNA from a variety of mycobacterial species.




As another approach to display genomic polymorphisms, the inventors have also started to use selected H37Rv BACs for “molecular combing” experiments in combination with fluorescent in situ hybridization (Bensimon et al., 1994; Michalet et al., 1997). With such techniques the one skilled in the art is enabled to explore the genome of mycobacteria in general and of


M. tuberclosis


in particular for further polymorphic regions.




The availability of BAC-based genomic mycobacterial DNA libraries constructed by the inventors have allowed them to design methods and means both useful to identify genomic regions of interest of pathogenic mycobacteria, such as


Mycobacterium tuberculosis


, that have no counterpart in the corresponding non-pathogenic strains, such as


Mycobacterium bovis


BCG, and useful to detect the presence of polynucleotides belonging to a specific mycobacterium strain in a biological sample.




By a biological sample according to the present invention, it is notably intended a biological fluid, such as plasma, blood, urine or saliva, or a tissue, such as a biopsy.




Thus, a first object of the invention consists of a method for isolating a polynucleotide of interest that is present in the genome of a mycobacterium strain and/or is expressed by said mycobacterium strain and that is absent or altered in the genome of a different mycobacterium strain and/or is not expressed in said different mycobacterium strain, said method comprising the use of at least one clone belonging to a genomic DNA library of a given mycobaterium strain, said DNA library being cloned in a bacterial artificial chromosome (BAC).




The invention is also directed to a polynucleotide of interest that has been isolated according to the above method and in partoular a polynucleotide containing one or several Open Reading Frames (ORFs), for example ORFs encoding either a polypeptide involved in the pathogenicity of a mycobacterium strain or ORFs encoding Polymorphic Glycine Rich Sequences (PGRS).




Such polynucleotides of interest may serve as probes or primers in order to detect the presence of a specific myobacterium strain in a biological sample or to detect the expression of specific genes in a particular mycobacterial strain of interest.




The BAC-based genomic mycobacterial DNA libraries generated by the present inventors are also part of the invention, as well as each of the recombinant BAC clones and the DNA insert contained in each of said recombinant BAC clones.




The invention also pertains to methods and kits for detecting a specific mycobacterium in a biological sample using either at least one recombinant BAC clone or at least one polynucleotide according to the invention, as well as to methods and kits to detect the expression of one or several specific genes of a given mycobacterial strain present in a biological sample.











III. BRIEF DESCRIPTION OF THE FIGURES




In order to better understand the present invention, reference will be made to the appended figures which depicted specific embodiments to which the present invention is in no case limited in scope with.




FIGS.


1


A and


1


B: PCR-screening for unique BAC clones with specific primers for 2 selected genomic regions of the H37Rv chromosome, using 21 pools representating 2016 BACs (Panel A) and sets of 20 subpools from selected positive pools (Panel B).




FIG.


2


: Pulsed-field gel electrophoresis gel of DraI-cleaved BAC clones used for estimating the insert sizes of BACs.




FIGS.


3


A-


3


D: Minimal overlapping BAC map of


M. tuberclosis


H37Rv superimposed on the integrated physical and genetic map established by Philipp et al. (18). Y- and I-numbers show pYUB328 (2) and pYUB412 (16) cosmids which were shotgun sequenced during the H37Rv genome sequencing project. Y-cosmids marked with * were shown in the integrated physical and genetic map (18). Rv numbers show the position of representative BAC clones relative to sequenced Y- and I-clones. Squared Rv numbers show BACs which were shotgun sequenced at the Sanger Centre.




FIGS.


4


A and


4


B: Ethidium bromide stained gel (Panel A) and corresponding Southern blot (PanelB) of EcoRI and PvuII digested Rv58 DNA hybridized with


32


P labeled genomic DNA preparations from


M. tuberclosis


H37Rv,


M. bovis


ATCC 19210 and


M. bovis


BCG Pasteur.




FIG.


5


: Organisation of the ORFs in the 12.7 kb genomic region present in


M. tuberculosis


H37Rv but not present in


M. bovis


ATCC 19210 and


M. bovis


BCG Pasteur. Arrows show the direction of transcription of the putative genes. Positions of EcoRI and PvuII restriction sites are shown. Vertical dashes represent stop codons. The 11 ORFs correspond to the ORFs MTCY277.28 to MTCY277.38/accession number Z79701-EMBL Nucleotide Sequence Data Library. The junction sequences flanking the polymorphic region are shown.




FIG.


6


: Variation in the C-terminal part of a PE-PGRS open reading frame in


M. tuberculosis


strain H37Rv relative to


M. bovis


BCG strain Pasteur.




The numbers on the right side of the Figure denote the position of the end nucleotides, taking as the reference the


M. tuberclosis


genome.




FIG.


7


: Polynucleotide sequence next to the HindIII cloning site in the BAC vector pBeloBAC11 (Kim et al., 1996) used to clone the inserts of the BAC-based myobacterial genomic DNA library according to the invention.




NotI: location of the NotI restriction sites.




Primer T7-BAC1: nucleotide region recognized by the T7-BAC1 primer shown in Table 1.




T7 promoter: location of the T7 promoter region on the pBeloBac11 vector.




Primer T7-Belo2: nucleotide region recognized by the T7-Belo2 pimer shown in Table 1.




Hind III: the HindIII cloning site used to clone the genomic inserts in the pBeloBAC11 vector.




SP6-Mid primer: nucleotide region recognized by the SP6 Mid primer shown in Table 1.




SP6-BAC1 primer: nucleotide region recognized by the SP6 BAC1 primer shown in Table 1.




SP6 promoter: location of the SP6 promoter region on the pBeloBac11 vector.











IV. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS




As already mentioned hereinbefore, the present invention is directed to a method for isolating a polynucleotide of interest that is present in the genome of a mycobacterium strain and/or is expressed by said mycobacterium strain and that is absent or altered in the genome of a different mycobacterium strain and/or is not expressed in said different mycobacterium strain, said method comprising the use of at least one clone belonging to a genomic DNA library of a given mycobaterium strain, said DNA library being cloned in a bacterial artificial chromosome (BAC).




For this purpose, the inventors have constructed several BAC-based mycobacterial genomic DNA libraries that may be used in order to perform the above described method.




Because it is the first time that mycobacterial genomic DNA has been successfully cloned in BAC type vectors, and because these DNA libraries are then novel and nonobvious, an object of the present invention consists in a myobacterial genomic DNA library cloned in such a BAC type vector.




As an illustrative example, a BAC-based DNA library of


Mycobacterium tuberculosis


has been realized. Forty-seven cosmids chosen from the integrated map of the 4.4 Mb circular chromosome (Philipp et al., 1996a) were shotgun-sequenced during the initial phase of the H37Rv genome sequence project. The sequences of these clones were used as landmarks in the construction of a minimally overlapping BAC map. Comparison of the sequence data from the termini of 420 BAC clones allowed us to establish a minimal overlapping BAC map and to fill in the existing gaps between the sequence of cosmids. As well as using the BAC library for genomic mapping and sequencing, we also tested the system in comparative genomic experiments in order to uncover differences between two closely related mycobacterial species. As shown in a previous study (Philipp et al., 1996b),


M. tuberclosis, M. bovis


and


M. bovis


BCG, specifically BCG Pasteur strain, exhibit a high level of global genomic conservation, but certain polymorphic regions were also detected. Therefore, it was of great interest to find a reliable, easy and rapid way to exactly localize polymorphic regions in mycobacterial genomes using selected BAC clones. This approach was validated by determining the exact size and location of the polymorphisms in the genomic region of Dral fragment Z4 (Philipp et al., 1996b), taking advantage of the availability of an appropriate BAC clone covering the polymorphic region and the H37Rv genome sequence data. This region is located approximately 1.7 Mb from the origin of replication.




The Bacterial Artificial Chromosome (BAC) cloning system is capable of stably propagating large, complex DNA inserts in


Escherichia coli


. As part of the


Mycobacterium tuberculosis


H37Rv genome sequencing project, a BAC library was constructed in the pBeloBAC11 vector and used for genome mapping, confirmation of sequence assembly, and sequencing. The library contains about 5000 BAC clones, with inserts ranging in size from 25 to 104 kb, representing theoretically a 70 fold coverage of the


M. tuberclosis


genome (4.4 Mb). A total of 840 sequences from the T7 and SP6 termini of 420 BACs were determined and compared to those of a partial genomic database. These sequences showed excellent correlation between the estimated sizes and positions of the BAC clones and the sizes and positions of previously sequenced cosmids and the resulting contigs. Many BAC clones represent linking clones between sequenced cosmids, allowing full coverage of the H37Rv chromosome, and they are now being shotgun-sequenced in the framework of the H37Rv sequencing project. Also, no chimeric, deleted or rearranged BAC clones were detected, which was of major importance for the correct mapping and assembly of the H37Rv sequence. The minimal overlapping set contains 68 unique BAC clones and spans the whole H37Rv chromosome with the exception of a single gap of ˜150 kb. As a post-genomic application, the canonical BAC set was used in a comparative study to reveal chromosomal polymorphisms between


M. tuberclosis, M. bovis


and


M. bovis


BCG Pasteur, and a novel 12.7 kb segment present in


M. tuberclosis


but absent from


M. bovis


and


M. bovis


BCG was characterized. This region contains a set of genes whose products show low similarity to proteins involved in polysaccharide biosynthesis. The H37Rv BAC library therefore provides the one skilled in the art with a powerfill tool both for the generation and confirmation of sequence data as well as for comparative genomics and a plurality of post-genomic applications.




The above described BAC-based


Mycobacterium tuberculosis


genomic DNA library is part of the present invention and has been deposited in the Collection Nationale de Cultures de Microorganismes (CNCM) on Nov. 19, 1997 under the accession number I-1945.




Another BAC-based DNA library has been constructed with the genomic DNA of


Mycobacterium bovis


BCG, Pasteur strain, and said DNA library has been deposited in the Collection Nationale de Cultures de Microorganismes (CNCM) on Jun. 30, 1998 under the accession number I-2049.




Thus, as a specific embodiment of the above described method for isolating a polynucleotide of interest said method makes use of at least one BAC-based DNA library that has beeen constructed from the genomic DNA of


Mycobacterium tuberculosis


, more specifically of the H37Rv strain and particularly of the DNA library deposited in the accession number I-1945.




In another specific embodiment of the above described method for isolating a polynucleotide of interest said method makes use of at least one BAC-based DNA library has beeen constructed from the genomic DNA of


Mycobacterium bovis


BCG, more specifically of the Pasteur strain and particularly of the DNA library deposited in the accession number I-2049.




In more details, the method according to the invention for isolating a polynucleotide of interest may comprise the following steps:




a) Isolating at least one polynucleotide contained in a clone of a BAC-based DNA library of mycobacterial origin;




b) Isolating:




at least one genomic or cDNA polynucleotide from a mycobacterium, said mycobacterium belonging to a strain different from the strain used to construct the BAC-based DNA library of step a); or alternatively




at least one polynucleotide contained in a clone of a BAC-based DNA library prepared from the genome of a mycobacterium that is different from the mycobacterium used to construct the BAC-based DNA library of step a);




c) Hybridizing the at least one polynucleotide of step a) to the at least one polynucleotide of step b);




d) Selecting the at least one polynucleotide of step a) that has not formed a hybrid complex with the at least one polynucleotide of step b);




e) Characterizing the selected polynucleotide.




Following the above procedure, the at least one polynucleotide of step a) may be prepared as follows:




1) Digesting at least one recombinant BAC clone by an appropriate resctriction endonuclease in order to isolate the polynucleotide insert of interest from the vector genetic material;




2) Optionally amplifying the resulting polynucleotide insert;




3) Optionally digesting the polynucleotide insert of step 1) or step 2) with at least one restriction endonuclease.




The above method of the invention allows the one skilled in the art to perform comparative genomics between different strains or species of mycobacteria cells, for example between pathogenic strains or species and their non pathogenic strains or species counterparts, as it is the illustrative case for the genomic comparison between


Mycobacterium tuberculosis


and


Mycobacterium bovis


BCG that is described herein in the examples.




Restriction digests of a given clone of a BAC library according to the invention may be blotted to membranes, and then probed with radiolabeled DNA form another strain or another species of mycobacteria, allowing the one skilled in the art to identify, characterize and isolate a polynucleotide of interest that may be involved in important metabolical and/or physiological pathways of the mycobacterium under testing, such as a polynucleotide functionally involved in the pathogenicity of said given mycobacteria for its host organism.




More specifically, the inventors have shown in Example 6 that when restriction digests of a given clone of the BAC library identified by the CNCM accession number I-1945 are blotted to membranes and then probed with radiolabeled total genomic DNA from, for example,


Mycobacterium bovis


BCG Pasteur, it is observed that restriction fragments that fail to hybridize with the


M. bovis


BCG Pasteur DNA are absent from its genome, hence identifying polymorphic regions between


M. bovis


BCG Pasteur and


M. tuberclosis


H37Rv.




Thus, a further object of the present invention consists in a polynucleotide of interest that has been isolated according to the method described herein before.




In Example 6, a polynucleotide of approximately 12.7 kilobases has been isolated that is present in the genome of


M. tuberclosis


but is absent of the genome of


M. bovis


BCG. This polynucleotide of interest contains 11 ORFs that may be involved in polysaccharide biosynthesis. In particular, two of said ORFs are of particular interest, namely ORF6 (MTCY277.33; Rv1511) that encodes a protein that shares significant homology with bacterial GDP-D-mannose dehydratases, whereas the protein encoded by ORF7 (MTCY277.34; Rv1512) shares significant homology with a nucleotide sugar epimnerase. As polysaccharide is a major constituent of the mycobacterial cell wall, these deleted genes may cause the cell wall of


M. bovis


BCG to differ from that of


M. tuberclosis


, a fact that may have important consequences for both the immune response to


M. bovis


BCG and virulence. Detection of such a polysaccharide is of diagnostic interest and possibly useful in the design of tuberculosis vaccines.




Consequently, the polynucleotide of interest obtained following the method according to the invention may contain at least one ORF, said ORF preferably encoding all or part of a polypeptide involved in an important metabolical and/or physiological pathway of the mycobacteria under testing, and more specifically all or part of a polypeptide that is involved in the pathogenicity of the mycobacteria under testing, such as for example


Mycobacterium tuberculosis


, and more generally mycobacteria belonging to the


Mycobacterium tuberculosis


complex.




The


Mycobacterium tuberculosis


complex has its usual meaning, i.e. the complex of mycobacteria causing tuberculosis which are


Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium africanum, Mycobacterium microti


and the vaccine strain


Mycobacterium bovis


BCG.




An illustrative polynucleotide of interest according to the present invention comprises all or part of the polynucleotide of approximately 12.7 kilobases that is present in the genome of


M. tuberclosis


but is absent from the genome of


M. bovis


BCG disclosed hereinbefore. This polynucleotide is contained in clone Rv58 of the BAC DNA library I-1945.




Generally, the invention also pertains to a purified polynucleotide comprising the DNA insert contained in a recombinant BAC vector belonging to a BAC-based mycobacterial genomic DNA library, such as for example the I-1945 BAC DNA library.




Advantageously, such a polynucleotide has been identified according to the method of the invention.




Such a polynucleotide of interest may be used as a probe or a primer useful for specifically detecting a given mycobacterium of interest, such as


Mycobacterium tuberculosis


or


Mycobacterium bovis


BCG.




More specifically, the invention then deals with a purified polynucleotide usefill as probe or a primer comprising all or part of the nucleotide sequence SEQ ID N


o


1:














ACCTGCGCTT GCAGAGATCA AATAGGGCGC ATGGGTCAGC ATAGTACAGG TCGTCGCGCA




60














TCTTTGATGC ATCGGAATAA GATGTCAGGC AATTAAAAGA GAAGCCACGG CGACTCGCGG




120













CATTCAGCAT GTCGAGCGTC GCTTCGATGT GAGCGCACCA TTCCGTGTCC AACGATTTCA




180













GACGAACATT GAATATTCCA CTCGCGACGC TATAGTCCGC CTCCCGATCT ATGCGCGCCG




240













CGCAGATGAA GTCTGCGTTC GCCCGACCTT CGAAACGTAG TGCGGCCGCG CGCACCATTT




300













CGGGGGAGAC GTCGATGCCG GTGTAATCAG TTTTGAAGCC ACGCGCATCT AGGTAGTCCA




360













GTAGAGCCCC ATAGCCACAG CCTAGATCGT TGATCGAAAA TGGGTCCGCC GCATTGACAA




420













TGCGCACCAG CTGGTCAAAG CGCAACGCCT GCCCGGCTTC GCCGTTCCAA TCGACGCCGC




480













GCGGGTGCCG TGTGCTTCGA GTTTCGATGC GTAGTAACGG GCCACGTCAG CGAGCATGGT




540













CGTTGCGTCT TCCGCCATGA AGCTGCCTCA CGATTTGTGT GTGTGGGCGT CGGTGCGTGG




600













GTCCGAGACT ATACCTTCAA CAGTTGCATG CCGAGGCTGC GGCGGGCAAT GACCCAAAAA




660













CCCGCCGGCA CGGTTCGCCG AGCAAGGAAG CGTGGAGACG ATAGATAATT TCACTGGCGA




720













CAGTACCTCA AATAGTCCGG AGCCTCGGCT CCGACGTTAA AGAGCAGATC CAGAATCGAC




760













ACGGCGGGCT CGAACCCTCC CCACAATTGC TTATAATCGC GGTAGCCGTC ATAATCGAAC




840













CAAGTTACCC GGATGCTAAG TTCGTCGAAC ACGCGCTCAT CGACATACGA ACGGGCTGAG




900













GGGCCAGAGA CATATTCGGT CGCTGCGGCC TGTTGGCAGA GGTTGGCCAG TCTCTCGGTC




960













TTGCCGTCGG CTAATTCGTA GTCCCACGAA TTTGCCAGTC GCGTGCTGAT ACCGAGATAA




1020













CTGCAAATCG CATTCAATAG ACGCCTGTTG AGTAAGGAAA GATTCGTGTG CTGTTCTTCG




1080













AGGTAAATCG GCGCGAGCCA GTCAGCGATC TCCGCAAAAT GAGCGGCCGC GCTGTAGTTG




1140













AATTCTAGTG CCCGCCAGTG CGCTTTCGCC CAATCGGTGC CGTCGATCAG CGTCTCACGT




1200













ATCTTTTGAT GGAAACGTCC CTTCACCTGG ACGGGAACAG TTATCCACTG TAACCCCTGG




1260













CTCGTTTTGA TCCGATTTCT GTTTCGCCAA TCACGCTTGG TATATTGCAT GTCATCATAG




1320













ATGATGAATT CATCGACGAA TGCAATCAGG TCAAAATATC CTCGCCAAGG TATGTAATTT




1380













GATTGAACAA TCGCGACTTT CTTCAACGCG GTGTCTCCAA TTTAGAATAA CAAATACGTC




1440













GCGCCCGCGA CAGCTCCGCT GGAGCGAGTT CAAGCGATTC TGCGACATAT TCAATATGGT




1500













GCTCGGGAAG GCCAGGATGG GCCGCGACCC GGGGCGTCCG GTGCGCGATG AACGTCGCAT




1560













CGTCTCCTGT GAGATAATTG CATCCGATCA TATAGGGCTG GCTGCGGCTA GGTTGCTGGC




1620













AAAAAGATAT CGCGGCCGAT CCGTTTCTGG TTTTGTCTTG ATGATCAAAT CCGCTTCCGT




16B0













TCACGAGATC GATTCCTGGT CTTCCCCCAG CGTCGCGATG TCGATAGGTG TCGCGCTTTG




1740













TTCGTACCCG CACTACGCGG CGGCGAGAAC CTCGCCACCG AATCGGGATT GGGGGGAGGA




1800













TACCACTCGG TCGAGGCCCG TCACCGGCCT TCTAGCGGGT TGACCATCAG TGTTTGCAGG




1860













GCCCTATCCC GGTATGGCGC ACCACGGGAT CGGCAGCGTT CCGGTTGCTG GCGTGGTACC




1920













TCGTTGTGGC GCCGTGGTCC ATGTCGATTG AGTGCGTGGA TCAGTGTAAA CCGTTGCGCG




1980













CCATGTTCTG TAGGCACTGG TTCGGGTTGT GGTTAGGCTG CACGGTTGGC AGGTTACCAA




2040













CCACTGAGCC CCTGGGCGGA TGTGAGCTCG GACTCCGCCT ATGGGGTGTA ATTTTGGCAG




2100













ATTGGGCCGG GTCCCCGTGG TGAGGACTCC TCAACCGGAT TGGGTAAGCA TGAGGTGGTG




2160













CTGGCAGCGG TGTCCTGGTC GCTCTCCCGA GTAGGCCCGT TGTGACTGTC ATGTGGGCGA




2220













GCGGGTTTGC GCGCGTAGGA GACGATGATT ACTACGCACG TGACCAACCA CAAGAACGGT




2280













GCCCATGTCA CCGTGGTGAA AACGAGTGGC GTGGTACCGA CTACCCCTTT GGCTCCCAGC




2340













TGTCCATAGA GCGGCACGTA GAACGGCTGG CCCGGGACCG CGACGTTGAC GATGCTCAGC




2400













GCCACGGCCA AACTCACGCA GACGCCGACC GCGCGGCGGC GGTCTCCATG GGCTGCGAGT




2460













TGGTCGAATA TCCCAGCACC AGGAGGCCCG TTGGGGTCTC GGGCTACCAG TGCAGCGATT




2520













GGCAAGACGA AAACGAGATA GTAGAAGGCG ACGTCCGCGG GGGAGAAGGT GGCGGTGGCG




2580













AGCAACACAA TCCCCACCAT GACAGGCGGG ATACGGCGTC CGAGCGCCAG CACGGCGACC




2640













ACGACTATGA CTAGGACAGC AAACCCGATC TGCGTTCGCG GACCAGTGAG GAAACCCTCT




2700













GGGATCTTGC CCGATTGATA GTTCTTGATG CTATCGGGGA TCAGCAGGAG TGCCTTGCCA




2760













AAGGACACGT TCCGCGGGTC TCGAAGCCCT CCGAACGAAC TATTGAACTT GATGATGCCG




2820













TGGATCGACT GTGCGATCGT CCCCGGGAAG CCTCGTGGCC ACAACAGAAA GGCTGCGATA




2880













TTGGACACCA CCACGCCGGT GATCCCGATA CCAGCCCACC GCCATTGTCG AGCCGCCAAC




2940













AACACCACGC CGAGAACGAC GAACTGCGGC TTTACCAGGA CGGCCAAGAT CACCGTGATG




3000













GTGGCGAGGC CCCACCGCTG TCGGGACAAC GCCACGAAGT AAGCCAGCGC GATCGGTACC




3060













ACGAACCCTG TCGAGTTGCC TCGATCGATG ACCCCCCACG CCGGGATGGC CGCGGCGCCC




3120













AGTGTCACGA AGATGACCAC TCGCTCCAGA CCACGTGCCC CCCGGGCCGC CCAGATGGCG




3180













GGAGATATGA CCGCCATCGT TAGGGCGACC AGGTAACAGA TCAGCCCCAA GCGCGGCGCA




3240













CCCAGCCAAT GGCTGGGTAG TCCGAAAATC GCATACGGTA TGCGGGCGGG GGCCCATGCA




3300













GCAACCGCGG TCGGCTGGTA ATCGGCGGGT AGCGAGATCA GGTAGTCCGC GGGATTGGGT




3360













TGAATCCCGG CGGCGGCGAC CATGGCGTAG TCGCTGAAGC AGTGCCGACC GATATTCATG




3420













CCCCAATCAA GCCAACAGTC CCCAGGGACT ACCAAAAGAG TGGAAAAGAC GTCGACCGCG




3480













TACCACTGAC TGAGGGCGTA CGCCGTCGCC GCCGAAATCA CCGACGCCAG CAGGATGGTG




3540













CCGAGCATGA GGGTGCGCTC GGATTGGGAG CCGATCGCCC AGAGCCGCTC CCGGCTCGCG




3600













GTCACGGCAC CGCGCAACAC CTCCGGGGGT CGCTTCATCT GGATTCTCCT CGGTTCTGCG




3660













CGAAACGGTA GCAGAGCGCC ATGGTTGCCA ACGCGGTCGC CGGGCAGTCT AGACCGGATC




3720













TTCCTCGTGG CAACCGACAA CAGGACGTCG TTGCCGAAAG GGCGCTGGGC ACCGACATCT




3780













AGGATGAACC CACAGCCACG CCCCGACGTT ATGCCATGGC GAAGAGCGAC CGGCAGGAGC




3840













GGGAACCCAG TGAAGCGAGC GCTCATCACC GGAATCACAG GACCGGACGG CTCGTATCTC




3900













GCTAAGCTCC CGCTGAAGGG ATATGTGGCC GCTGGTAGCC CGGCCGAGGT CTATTTCTGC




3960













TGGGCGACAC GGAATTATCG CGAATTGTAT GGGTTGCTCG CGGTCAACAG CATCTGGTTC




4020













AATCACGAAT CACCGCGTCA CGGCGAGACA TTCATGACTC GTAATCCTGC ACCATATCGC




4080













GGTCGGCAAC GAGGCGCTGA TCGATGCGCA GACGCTGATG CGCCGGCCCA CCCGGATAGG




4140













TATCAGTATT GGGGCGTTCC GGCCAGCGTA CGAGGCGTGA TCGACCGCGC AATGGGTGTT




4200













TGCGTTGAGT AATAATCTGA ACCGTGTGAA CGCATGCATG GATGGATTCC TTGCCCGTAT




4260













CCGCTCACAT GTTGATGCGC ACGCGCCAGA ATTGCGTTCA CTGTTCGATA CGATGGCGGC




4320













CGAGGCCCGA TTTGCACGCG ACTGGCTGTC CGAGGACCTC GCGCGGTTGC CTGTCGGTGC




4380













AGCATTGCTG GAAGTGGGCG GGGGGGTACT TCTGCTCAGC TGTCAACTGG CGGCGGAGGG




4440













ATTTGACATC ACCGCCATCG AGCCGACGGG TGAAGGTTTT GGCAAGTTCA GACAGCTTGG




4500













CGACATCGTG CTGGAATTGG CTGCAGCACG ACCCACCATC GCGCCATGCA AGGCGGAAGA




4560













CTTTATTTCC GAGAAGCGGT TCGACTTCGC CTTCTCGCTG AATGTGATGG AGCACATCGA




4620













CCTTCCGGAT GAGGCAGTCA GGCGGGTATC GGAAGTGCTG AAACCGGGGG CCAGTTACCA




4680













CTTCCTGTGC CCGAATTACG TATTCCCGTA CGAACCGCAT TTCAATATCC CAACATTCTT




4740













CACCAAAGAG CTGACATGCC GGGTGATGCG ACATCGCATC GAGGGCAATA CGGGCATGGA




4800













TGACCCGAAG GGAGTCTGGC GTTCGCTCAA CTGGATTACG GTTCCCAAGG TGAAACGCTT




4860













TGCGGCGAAG GATGCGACGC TGACCTTGCG CTTCCACCGT GCAATGTTGG TATGGATGCT




4920













GGAACGCGCG CWGACGGATA AGGAATTCGC TGGTCGCCGG GCACAATGGA TGGTCGCTGC




4980













TATTCGCTCG GCGGTGAAAT TGCGTGTGCA TCATCTGGCA GGCTATGTTC CCGCTACGCT




5040













GCAGCCCATC ATGGATGTGC GGCTAACGAA GAGGTAATGA CATGGCGCAA GCGACATCGG




5100













GCATTCGCGC GGCACTTTCG CAACCTGCTG TGTATGAGGC GTATCAGCGG ATTGCGGGCG




5160













CTAAAAGCGG GCTTGCGTGG ATCACAACCG ACCCCATCCA GTCGTTGCCA GGCATGCGTA




5220













CTCTCGACCT CGGTTGCTGG CCAGCGGTGA TACACAGCTC CCCGCCAGTG GACGTGACAT




5280













GTACGAGAGA CGGCATGAGC GCGGAATGTG CGACCGTGCC GTCGAGATGA CCGACGTCGG




5340













CGCTACGGCA GCCCCCACCG GACCTATCGC GCGGGGCAGC GTCGCTCGGG TCGGCGCGGC




5400













GACCGCGTTG GCCGTTGCCT GCGTCTACAC GGTCATCTAT CTGGCGGCCC GCGACCTACC




5460













CCCGGCTTGT TTTTCGATAT TCGCGGTGTT TTGGGGGGCG CTCGGCATTG CCACCGGCGC




5520













CACCCACGGC CTCCTGCAAG AAACGACCCG CGAGGTCCGC TGGGTGCGCT CCACCCAAAT




5580













AGTTGCGGGC CATCGTACCC ATCCGCTGCG GGTGGCCGGG ATGATTGGCA CCGTCGCGGC




5640













CGTCGTAATT GCGGGTAGCT CACCGCTGTG GAGCCGACAG CTATTCGTCG AGGGGCGCTG




5700













GCTGTCCGTG GGGCTACTCA GCGTTGGGGT GGCCGGGTTC TGCGCGCAGG CGACCCTGCT




5760













GGGCGCGCTG GCCGGCGTCG ACCGGTGGAC ACAGTACGGG TCACTGATGG TGACCGACGC




5820













GGTCATCCGG TTGGCGGTCG CCGCGGCAGC GGTTGTGATC GGATGGGGTC TGGCCGGGTA




5880













CTTGTGGGCC GCCACCGCGG GAGCGGTGGC GTGGCTGCTC ATGCTGATGG CCTCGCCCAC




5940













CGCGCGCAGC GCGGCCAGCC TGCTGACGCC CGGGGGAATC GCCACGTTCG TGCGCGGTGC




6000













CGCTCATTCG ATAACCGCCG CGGGTGCCAG CGCGATTCTG GTAATGGGTT TCCCAGTGTT




6060













GCTCAAAGTG ACCTCCGACC AGTTAGGGGC AAAGGGCGGA GCGGTCATCC TGGCTGTGAC




6120













CTTGACGCGT GCGCCGCTTC TGGTCCCACT GAGCGCGATG CAAGGCAACC TGATCGCGCA




6180













TTTCGTCGAC CGGCGCACCC AACGGCTTCG GGCGCTGATC GCACCGGCGC TGGTCGTCGG




6240













CGGCATCGGT GCGGTCGGGA TGTTGGCCGC AGGGCTTACC GGTCCCTGGT TGCTGCGTGT




6300













TGGATTCGGC CCCGACTACC AAACTGGCGG GGCGTTGCTG GCCTGGTTGA CGGCAGCGGC




6360













GGTAGCTATC GCCATGCTGA CGCTGACCGG CGCCGCCGCG GTCGCGGCCG CACTGCACCG




6420













GGCGTATTTG CTGGGCTGGG TCAGCGCGAC GGTGGCGTCG ACGCTGTTGC TGCTGCTGCC




6480













GATGCCGCTG GAGACGCGCA CCGTGATCGC GCTGTTGTTC GGTCCAACGG TGGGAATCGC




6540













CATCCATGTG GCCGCGTTGG CGCGGCGACC CGACTGATTT GTGCCCCAGG TCGACAAATC




6600













ACGCCGTCTC GTCAGTGAGC ACTCCGTCCT CGGGTCCGAT CCTTCCAGGA GACGTTGCAA




6660













CCTGATTTGG CTCAAATTGG TGCGCACCGA GGGTCGGGCA CATCGTAGGG TCGCAACAGT




6720













CACATGTGTC ACTGCACCGG GCGACACCCG ATGTCCCGGC TCTCAGCGAC AGCTGTCTGA




6780













CCTGTGGTTT TGTTCCCAAG TTGGTCGTGG CTGTGCGGGA TTGGAGGTGG CGTGGGGGTC




6840













GCGTCGTATG GATTCTCCTC CTCGGTTCCG CGCGAAACGG CCGCAGGCGC AATGGTCACC




6900













AACTTGGCCG CGGTGGAGTC TAGCCTCACA TTTTCCTGGT CGCCCCCGAC AACCAGGAGG




6960













TCGCTGCAGA ACGGGCGTTC CCTACCCACA TCTACTATGA AGCGACAGCG GCGCCCCGCT




7020













GTGATGGCTG AGCATGACCG ACAGAGGCGG GAAGACAGTG AAGCGAGCGC TCATCACCGG




7080













AATCACCGGC CAGGACGGCT CGTATCTCGC CGAACTGCTG CTGGCCAAGG GGTATGAGGT




7140













TCACGGGCTC ATCCGGCGCG CTTCGACGTT CAACACCTCG CGGATCGATC ACCTCTACGT




7200













CGACCCGCAC CAACCGGGCG CGCGGCTGTT TCTGCACTAT GGTGACCTGA TCGACGGAAC




7260













CCGGTTGGTG ACCCTGCTGA GCACCATCGA ACCCGACGAG GTGTACAACC TGGCGGCGCA




7320













GTCACACGTG CGGGTGAGCT TCGACGAACC CGTGCACACC GGTGACACCA CCGGCATGGG




7380













ATCCATGCGA CTGCTGGAAG CCGTTCGGCT CTCTCGGGTG CACTGCCGCT TCTATCAGGC




7440













GTCCTCGTCG GAGATGTTCG GCGCCTCGCC GCCACCGCAG AACGAGCTGA CGCCGTTCTA




7500













CCCGCGGTCA CCGTATGGCG CCGCCAAGGT CTATTCGTAC TGGGCGACCC GCAATTATCG




7560













CGAAGCGTAC GGATTGTTCG CCGTTAACGG CATCTTGTTC AATCACGAAT CACCGCGGCG




7620













CGGTGAGACG TTCGTGACCC GAAAGATCAC CAGGGCCGTG GCACGCATCA AGGCCGGTAT




7680













CCAGTCCGAG GTCTATATGG GCAATCTGGA TGCGGTCCGC GACTGGGGGT ACGCGCCCGA




7740













ATACGTCGAA GGCATGTGGC GGATGCTGCA GACCGACGAG CCCGACGACT TCGTTTTGGC




7800













GACCGGGCGC GGTTTCACCG TGCGTGAGTT CGCGCGGGCC GCGTTCGAGC ATGCCGGTTT




7860













GGACTGGCAG CAGTACGTGA AATTCGACCA ACGCTATCTG CGGCCCACCG AGGTGGATTC




7920













GCTGATCGGC GACGCGACCA AGGCTGCCGA ATTGCTGGGC TGGAGGGCTT CGGTGCACAC




7980













TGACGAGTTG GCTCGGATCA TGGTCGACGC GGACATGGCG GCGCTGGAGT GCGAAGGCAA




8040













GCCGTGGATC GACAAGCCGA TGATCGCCGG CCGGACATGA ACGCGCACAC CTCGGTCGGC




8100













CCGCTTGACC GCGCGGCCCG GGTCTACATC GCCGGGCATC GCGGCCTGGT CGGGTCCGCG




8160













CTGCTACGCA CGTTTGCGGG CGCGGGGTTC ACCAACCTGC TGGTGCGGTC ACGCGCCGAG




8220













CTTGATCTGA CGGATCGGGC CGCGACGTTC GACTTCGTTC TCGAGTCGAG GCCGCAGGTC




8280













GTCATCGACG CGGCGGCCCG GGTCGGCGGC ATCCTGGCCA ACGACACCTA CCCGGCCGAT




8340













TTCCTGTCGG AAAACCTCCA GATCCAGGTC AACCTGCTGG ATGCCGCCGT GGCGGCGCGG




8400













GTGCCGCGGC TGCTGTTCCT GGGCTCGTCG TGCATCTACC CGAAACTCGC CCCGCAGCCG




8460













ATCCCGGAGA GCGCGCTGCT CACCGGTCCG TTGGAGCCGA CCAACGACGC GTACGCGATC




8520













GCCAAAATCG CCGGCATCCT TGCGGTCCAG GCGGTGCGCC GCCAACATGG CCTGCCGTGG




8S80













ATCTCGGCGA TGCCCACCAA CCTGTACGGG CCAGGCGACA ACTTTTCGCC GTCCGGCTCG




8640













CATCTGCTGC CGGCACTCAT CCGCCGCTAT GACGAGGCCA AAGCCAGTGG CGCGCCCAAC




8700













GTGACCAACT GGGGCACCGG CACGCCCCGA CGGGAGTTGC TGCACGTCGA CGACCTGGCG




8760













AGCGCATGCC TGTATCTGCT GGAACATTTC GACGGGCCGA CCCATGTCAA CGTGGGAACC




8820













GGCATCGACC ACACCATCGG CGAGATCGCC GAGATGGTCG CCTCGGCGGT AGGCTATAGC




8880













GGCGAAACCC GCTGGGATCC AAGCAAACCG GACGGAACAC CACGCAAACT GCTGGATGTT




8940













TCGGTGCTAC GGGAGGCGGG ATGGCGGCCT TCGATCGCGC TGCGCGACGG CATCGAGGCG




9000













ACGGTGGCGT GGTATCGCGA GCACGCGGGA ACGGTTCGGC AATGAGGCTG GCCCGTCGCG




9060













CTCGGAACAT CTTGCGTCGC AACGGCATCG AGGTGTCGCG CTACTTTGCC GAACTGGACT




9120













GGGAACGCAA TTTCTTGCGC CAACTGCAAT CGCATCGGGT CAGTGCCGTG CTCGATGTCG




9180













GGGCCAATTC GGGGCAGTAC GCCAGGGGTC TGCGCGGCGC GGGCTTCGCG GGCCGCATCG




9240













TCTCGTTCGA GCCGCTGCCC GGGCCCTTTG CCGTCTTGCA GCGCAGCGCC TCCACGGACC




9300













CGTTGTGGGA ATGCCGGCGC TGTGCGCTGG GCGATGTCGA TGGAACCATC TCGATCAACG




9360













TCGCCGGCAA CGAGGGCGCC AGCAGTTCCG TCTTGCCGAT GTTGAAACGA CATCAGGACG




9420













CCTTTCCACC AGCCAACTAC GTGGGCGCCC AACGGGTGCC GATACATCGA CTCGATTCCG




9480













TGGCTGCAGA CGTTCTGCGG CCCAACGATA TTGCGTTCTT GAAGATCGAC GTTCAAGGAT




9S40













TCGAGAAGCA GGTGATCGCG GGTGGCGATT CAACGGTGCA CGACCGATGC GTCGGCATGC




9600













AGCTCGAGCT GTCTTTCCAG CCGTTGTACG AGGGTGGCAT GCTCATCCGC GAGGCGCTCG




9660













ATCTCGTGGA TTCGTTGGGC TTTACGCTCT CGGGATTGCA ACCCGGTTTC ACCGACCCCC




9720













GCAACGGTCG AATGCTGCAG GCCGATGGCA TCTTCTTCCG GGGCAGCGAT TGACGCGCCG




9780













GCGCGTCAAT CTATTTCGAC ATTCGCGTGA AGACGTTTTC CCAGAATCGA CTGTTGTAGG




9840













CGTAGAACTC CCGGCCGCGT AGGTAGGCAT GTGATATTCG CCTTCCCCCG AACGGGTAGC




9900













GGCGATGAAG GTCGCCCATG CGGCGCAGAT CACCGAAGAC CGCGCTTGGT TCCCGGTGCG




9960













AGCCGACGCC CGTGGTGTCG AACTCGCACA GCACACACCG AATCGTGACC GGCTCGCATA




10020













CCAGCGCGGC CCGCAATATG AATTCCTGGT CGGCGGCGAT CCCGAAATCA AGGTCGTAGC




10080













CACCGATCTT GGCCACCAGC GATGATCCGA AGAACGATGC TTGATGCGGA ACAACCTGCT




10140













TGCCGGCCAG GAATTTGCGC AGGCTGAAAG GTATCGGGCC GCGCACCCGA TCGAGCCCGA




10200













CGAGACGATC CATCCCGAAG CCCCACAATT CGGACACCGG TCCCTTGCCG GATAGCGCCT




10260













CCACGGCCTG GGCTACCACG TCGGGCCCGG AAAAACGATC GGCGGAGTGC AAGAACCACA




10320













ACAGATCACC CGATGCGTGC GCGATGCCCT GGTTCATCGC GTCGTACCGC CCGCCGTCGG




10380













GCTCGGACTG CCAATACGCG AAGCCTGGTT CACACCCGGA CAGGTATGCC ACCACGTCGT




10440













CGCCGCTGCC ACCGTCGATT ACGATGTGCT CGATGCGTCC CCGGTAGCGT TGCGCCCGCA




10500













CACTTTTCAC CGTGCGCTGC AACCCGTCGA GGTCGTTGAA CGAGATCGTT ATCACCGAGA




10560













CGGTCGGAGC AGACGTCACC GAGTTCCCCT AGGTTGCTGG CGGCGATTGT GGATCACCGG




10620













GTCTTGATAC CGATGAAGGT GCCTCGAAGA TTCGCCGCAT AGGAACCTCC GAGCAACGAC




106B0













TCGGCGATGC TTGGTTCCAA GTTGTCGTAC TCCTCCATCA CCAGGTCGAC GCCGACGTCT




10740













TTGATGGCCT GAAGTAGGTG CTCGCGTTGA ATCCAGAATG ACCGGCGATT GTCCCAGGAC




10800













GCCCATTTTG CGGTGTCGCG CTGGCCAAAC GAGCGGTCGT CGGAAAACTC GGTAAACCAC




10860













CTACCGGGAA GTCCCTCATG TTCGGTGGGC GCCGAGAGCA TGAACTTCAC CGGCGCCGGC




10920













CGCCGCAGCA ACCGATCGGT CAATTGTCGT GCCGTCGTGG GCAACCGGAG CCATTTATCG




10980













CTCCGGTTGA TGATCGAGAA GTGCGTCTGG AGAATCAGCA GCTTGTTCGT TACCGACGAG




11040













AGGGTTTCCA GGTATTGCTT CGGATTCTCC AGGTGGTAGA AGAGGCCGCA GCAGAAGACG




11100













GTATCGAAGA GCCCGTGGTT GGCGATGTTG AGGGCGTTGT CGTGGACGAA CCGGAGATTC




11160













GGCAGGTTGG TCTTCGATTT GATGTAGTTG CAGGCCGCCA TGTTCAGCTC GCGAACCTCG




11220













ATCCCGAGGA CCTGAAATCC CATGCGCGCG AACCCGACCG CGTACCCGCC TTCCAAGCAG




11280













CCGACATCGG CCAGGCGTAG GTGGCTCTTG TCCCCGGGAA AGACGGTTTC CAGAATCCCG




11340













CGCGCCGAGA TGAACCAGGA CGATTCGTCT AACGTGCGCG AGGACTCCGG TATCGTCAAG




11400













GTTCCGTCGT CGAGGCGAAC GTTGTGGGCG GTGAATTGTA CCGCGCCGGC CGAATGTTCC




11460













TGTGCCATCA CTTGGTTAGC CCCTTCGGCT GGTCCTGGGT TTGTCGACAT GGTCAGGCTC




11520













GACAGCCGCG TCGGAGCCGG GAGGGCCACA CATCCACGAG CCCCCTGCGG CTCGGCGTCG




11580













CGGCGGCGAG CTTGCGCCAC TGGGTCTTGA GCCGCCGCGC GGGTGTCGCC CCGCGGTGCT




11640













GCAGCGCCAG CATGGCGATC CGGGGATGGC GCGCGATGGT TTCCTGCAGC GCGGCGCGCC




11700













CCTCCGGGCC TGGAACGTTG GCGATCTGGC GAAGGATCCA GTCGGCCATG ACGGCGATGA




11760













GCTCCTCGCG CGCGGGGTCT CCCGGGAACA GGTCGAGCAT CGCGTCAAAC GTCGCCGCAT




11820













GCCCCGGACC CTGCGTCAAC CAGAACTTTG GCGGGTCCAC CACCTGGTTG TGCCACATGC




11880













CTTGGGCGTG GCGGCGATAC ACGGCCATGG TGTCGGGCAA CATGGCGATG TCGCCATGCA




11940













CCGCGTGCCG GACGTGCAGA TACCAGTCCA GGGGCATGAC GTCGGCAGGA ATGTCGTCGT




12000













AGCGCTCGAG GCGACGGTAC ACGGCCGAGT TGGTCTGGAT GAAGTTCATC AAGATCAACG




12060













CATCCAGGCT CAAGTTGCCC CGCACCCGAA CCGGGGGGAA CTTCGAGTCC TTGGCATGGC




12120













CGTCCTCCCA TATCACTCGG ACGGGATGGA AGCACACCGT CGTCTTGGGG TGCCGGTCGA




12180













GGAATGCGAC CTGTTTGCTT AGCTTCAGCG GATCGATCCA GTAGTCGTCC GCCTCGCACA




12240













ACGCGACGTA CTCGCCGCGA GCGGCCGACA GGGCGCCGGT CAGGTTCCCA TTGAGGCCGA




12300













GGTTTTCGGT CCTGAAGATC GGCCGGAACA CGTGCGGGTA CCGCTCGGCG TACTCACGGA




12360













TGATCGCCGG GGTGGCATCG GTCGACGCGT CGTCGGCGAC GATGATCTCC ACCGGGAAGT




12420













CGGTTTGCTG GTCGAGAAAG CTGTCGAAGG CCTGACGGGC GTAGCCCGCC TGGTTGTGAG




12480













TGGTCGAGAC GATGCTCACC TTGGGGCAAA GCTGGGGACT CACCGTCGGC CCTTTTCCTG




12540













CGCGGCCGCA AGGGTATTGC GATGGCGAAC GTGAATCGCC TGTGCCCGCC GGCCGTCGGC




12600













CGTCGTGGCC TGGTGGTCGG CGGACGTACG GCACACGCTG GCGAAGTATA GCGAGGGTGC




12660













ACTGACGTTG GGCTCGAACC GCGTGGCGCG CGGTGTGGGC GCACCGTCTC GAGTCGGTGC




12720













TGGTTGGCTC GC




12732











The location, on the


Mycobacterium tuberculosis


chromosome, of the above polynucleotide of sequence SEQ ID N


o


1 has now been ascribed to begin, at its 5′ end at nucleotide at position nt 1696015 and to end, at its 3′ end, at nucleotide at position nt 1708746.




For diagnostic purposes, this 12.7 kb deletion should allow a rapid PCR screening of tubercle isolates to identify whether they are bovine or human strains. The primers listed in Table 1 are flanking the deleted region and give a 722 bp amplicon in


M. bovis


or


M. bovis


BCG strains, but a fragment of 13,453 bp in


M. tuberclosis


that is practically impossible to amplify under the same PCR conditions. More importantly, assuming that some of the gene products from this region represent proteins with antigenic properties, it could be possible to develop a test that can reliably distinguish between the immune response induced by vaccination with


M. bovis


BCG vaccine strains and infection with


M. tuberclosis


or that the products (e.g. polysaccharides) are specific immunogens.




The invention also provides for a purified polynucleotide usefill as a probe or as a primer, said polynucleotide being chosen in the following group of polynucleotides:




a) a polynucleotide comprising at least 8 consecutive nucleotides of the sequence SEQ ID N


0


1.




b) a polynucleotide whose sequence is fully complementary to the sequence of the polynucleotide defined in a);




c) a polynucleotide that hybridizes under stringent hybridization conditions with the polynucleotide defined in a) or with the polynucleotide defined in b).




For the purpose of defining a polynucleotide or oligonucleotide hybridizing under stringent hybridization conditions, such as above, it is intended a polynucleotide that hybridizes with a reference polynucleotide under the following hybridization conditions:




The hybridization step is realized at 65° C. in the presence of 6×SSC buffer, 5×Denhardt's solution, 0,5% SDS and 100 μg/ml of salmon sperm DNA.




For technical information, 1×SSC corresponds to 0.15 M NaCl and 0.05M sodium citrate; 1×Denhardt's solution corresponds to 0.02% Ficoll, 0.02% polyvinylpyrrolidone and 0.02% bovine serum albumin.




The hybridization step is followed by four washing steps:




two washings during 5 min, preferably at 65° C. in a 2×SSC and 0.1%SDS buffer;




one washing during 30 min, preferably at 65° C. in a 2×SSC and 0.1% SDS buffer,




one washing during 10 min, preferably at 65° C. in a 0.1×SSC and 0.1%SDS buffer




A first illustrative useful polynucleotide that is included in the polynucleotide of sequence SEQ ID N


o


1 is the following polynucleotide of sequence SEQ ID N


o


2 that corresponds to the Sp6 endsequence of SEQ ID N


o


1:














ATACTCAAGC TTGCCGCAAT CGAAACCAAC CTGTTTGTGC CGCAAGAAAT TACGCCGTGG




 60














CCCGGCGCCG ATCAAGAAAC GCCCCGGCGC GCGGCGGTGT CGTCGTATGG CATGACGGGC




120













ACCAATGTGC ACGCCATTGT CGAGCAGGCA CCGGTGCCAG CCCCCGAATC CGGTGCACCA




180













GGCGACACCC CGGCCACACC CGGTATCGAC GGCGCGCTGC TGTTCGCGCT GTCGGCCAGC




240













TCGCAGGACG CGCTGCGGCA AACCGCCGCG CGGCTGGCCG ATTGGGTCT




289











A second illustrative useful polynucleotide that is included in the polynucleotide of sequence SEQ ID N


o


1 is the following polynucleotide of sequence SEQ ID N


o


3 that corresponds to the T7 endsequence of SEQ ID N


o


1, located on the opposite strand:














TTGGCGGGTT GGCCACACAC CCGCCGGTGA CGGCGACGAT GCTGGGCTGG TTGCGGCCCT




 60














GCGCCACCGC GGCTTGCATG CTGGTTGGCT GTCTTGGGAC GATCCCGAAA TAGTCCACGC




120













GGATCTGGTG ATTTTGCGGG CTACCCGCGA TTACCCCGCG CGGCTCGACG AGTTTTTGGC




180













CTGGACTACC CGCGTGGCCA ATCTGCTGAA CTCGCGGCCG GTGGTGGCCT GGAATGTCCA




240













CGCCGTTCAC CTACGTGACC TTGATGGGAT CCGGGGGT




278











The polynucleotide of sequence SEQ ID N


o


1 contains 11 ORFs, the respective locations of which, taking into account the orientation of each ORF on the chromosome, on the sequence of the


Mycobacterium tunerculosis


chromosome, is given hereafter:




The location of ORF1 is comprised between nucleotide at position nt 1695944 and nucleotide at position nt1696441.




The location of ORF2 is comprised between nucleotide at position nt 1696728 and nucleotide at position nt1697420.




The location of ORF3 is comprised between nucleotide at position nt 1698096 and nucleotide at position nt1699892. ORF3 probably encodes a protein having the characteristics of a membrane protein.




The location of ORF4 is comprised between nucleotide at position nt 1700210 and nucleotide at position nt1701088.




The location of ORF5 is comprised between nucleotide at position nt 1701293 and nucleotide at position nt1702588. ORF5 encodes a protein having the characteristics of a membrane protein.




The location of ORF6 is comprised between nucleotide at position nt 1703072 and nucleotide at position nt1704091. ORF6 encodes a protein having the characteristics of a GDP-D-mannose dehydratase.




The location of ORF7 is comprised between nucleotide at position nt 1704091 and nucleotide at position nt1705056. ORF7 encodes a protein having the characteristics of a nucleotide sugar epimerase involved in colanic acid biosynthesis.




The location of ORF8 is comprised between nucleotide at position nt 1705056 and nucleotide at position nt1705784.




The location of ORF9 is comprised between nucleotide at position nt 1705808 and nucleotide at position nt1706593. ORF9 encodes a protein having the characteristics of colanic acid biosynthesis glycosyl transferase.




The location of ORF10 is comprised between nucleotide at position nt 1706631 and nucleotide at position nt1707524.




The location of ORF11 is comprised between nucleotide at position nt 1707530 and nucleotide at position nt1708648. ORF11 encodes a protein similar to a spore coat polysaccharide biosynthesis.




A polynucleotide of interest obtained by the above-disclosed method according to the invention may also contain at least one ORF that encodes all or part of acidic, glycine-rich proteins, belonging to the PE and PPE families, whose genes are often clustered and based on multiple copies of the polymorphic repetitive sequences. The names PE and PPE derive from the fact that the motifs ProGlu (PE, positions 8, 9) and ProProGlu (PPE, positions 7 to 9) are found near the N-terminus in almost all cases. The PE protein family all have a highly conserved N-terminal domain of ˜110 amino acid residues, that is predicted to have a globular structure, followed by a C-terminal segment which varies in size, sequence and repeat copy number. Phylogenetic analysis separated the PE family into several groups, the larger of which is the highly repetitive PGRS class containing 55 members whereas the other groups share very limited sequence similarity in their C-terminal domains. The predicted molecular weights of the PE proteins vary considerably as a few members only contain the ˜110 amino acid N-terminal domain while the majority have C-terminal extensions ranging in size from 100 up to >1400 residues. A striking feature of the PGRS proteins is their exceptional glycine content (up to 50%) due to the presence of multiple tandem repetitions of GlyGlyAla or GlyGlyAsn motifs or variations thereof.




Like the PE family, the PPE protein family also has a conserved N-terminal domain that comprises ˜180 amino acid residues followed by C-terminal segments that vary considerably in sequence and length. These proteins fall into at least three groups, one of which constitutes the MPTR class characterised by the presence of multiple, tandem copies of the motif AsnXGlyXGlyAsnXGly (SEQ ID NO: 730). The second subgroup contains a characteristic, well-conserved motif around position 350 (GlyXXSerValProXXTrp)(SEQ ID NO: 731), whereas the other group contains proteins that are unrelated except for the presence of the common 180-residue PPE domain. C-terminal extensions may range in size from 00 up to 3500 residues.




One member of the PGRS sub-family, the WHO antigen 22T (Abou-Zeid et al., 1991), a 55 kD protein capable of binding fibronectin, is produced during disease and elicits a variable antibody response suggesting either that individuals mount different immune responses or that this PGRS-protein may not be produced in this form by all strains of


M. tuberculosis


. In other words, at least some PE_PGRS coding sequences encode for proteins that are involved in the recognition of


M. tuberclosis


by the immune system of the infected host Therefore, differences in the PGRS sequences could represent the principal source of antigenic variation in the otherwise genetically and antigenically homogeneous bacterium.




By performing the method of the invention using the


M. tuberclosis


BAC based DNA library I-1945, the inventors have discovered the occurence of sequence differences between a given PGRS encoding ORF (ORF reference on the genomic sequence of


M. tuberclosis


Rv0746) of


M. tuberclosis


and its counterpart sequence in the genome of


M. bovis


BCG.




More precisely, the inventors have determined that one ORF contained in BAC vector N Rv418 of the


M. tuberclosis


BCG I-1945 DNA library carries both base additions and base deletions when compared with the corresponding ORF in the genome of


M. bovis


BCG that is contained in the BAC vector N X0175 of the


M. bovis


BCG I-2049 DNA libary. The variations observed in the base sequences correspond to variations in the C-terminal part of the aminoacid sequence of the PGRS ORF translation product.




As shown in

FIG. 6

, an amino acid stretch of 29 residues in length is present in this


M. tuberclosis


PGRS (ORf reference Rv0746) and is absent from the ORF counterpart of


M. bovis


BCG, namely the following amino acid sequence:




NH


2


-GGAGGAGGSSAGGGGAGGAGGAGGWLLGD-COOH (SEQ ID NO: 732).




Furthermore ,

FIG. 6

shows also that an amino acid stretch of 45 residues in length is absent from this


M. tuberclosis


PGRS and is present in the ORF counterpart of


M. bovis


BCG, namely following amino acid sequence:




NH


2


-GAGGIGGIGGNANGGAGGNGGTGGQLWGSGGAGVEGGAALSVGDT-COOH (SEQ ID NO: 733).




Similar observations were made with PPE ORF Rv0442, which showed a 5 codon deletion relative to a


M. bovis


amino acid sequence.




Given that the polymorphism associated with the PE-PGRS or PEE ORFS resulted in extensive antigenic variability or reduced antigen presentation, this would be of immense significance for vaccine design, for understanding protective immunity in tuberculosis and, possibly, explain the varied responses seen in different BCG vaccination programmes.




There are several striking parallels between the PGRS proteins and the Epstein-Barr virus-encoded nuclear antigens (EBNA). Both polypeptide families are glycine-rich, contain Gly-Ala repeats that represent more than one third of the molecule, and display variation in the length of the repeat region between different isolates. The Gly-Ala repeat region of EBNA1 has been shown to function as a cis-acting inhibitor of antigen processing and MHC class I-restricted antigen presentation (Levitskaya et al., 1995). The fact that MHC class I knock-out mice are extremely suscepible to


M. tuberclosis


underlines the importance of MHC class I antigen presentation in protection against tuberculosis. Therefore, it is possible that the PE/PPE protein family also play some role in inhibiting antigen presentation, allowing the bacillus to hide from the host's immune system.




As such the novel and nonobvious PGRS polynucleotide from


M. bovis


which is homolog to the


M. tuberclosis


ORF Rv0746, and which is contained in the BAC clone N X0175 (See Table 4 for SP6 and T7 endsequences of clone n


o


X0175) of the I-2049


M. bovis


BCG BAC DNA library is part of the present invention, as it represents a starting material in order to define specific probes or primers usefill for detection of antigenic variability in mycobacterial strains, possible inhibition of antigen processing as well as to differentiate


M. tuberculosis


from


M. bovis


BCG.




Thus, a further object of the invention consists in a polynucleotide comprising the following sequence SEQ ID N


o


4:














CCGACCCAGA CACTGACCGG GCGACCGCTG ATCGGCAACG GCACCCCCGG GGCGGTCGGC




 60














AGCGGGGCCA CCGGGGCCCC CGGTGGGTGG CTGCTCGGCG ACGGCGGGGC CGGCGGGTCC




120













GGCGCGGCGG GCTCGGGCGC GCCCGGCGGG GCGGGCGGGG CTGCCGGGCT GTGGGGTACC




180













GGCGGGGCCG GCGGGATCGG CGGAGCCAGC ACCGTACTCG GCGGCACCGG CGGGGGAGGC




240













GGGGTCGGTG GGCTGTGGGG CGCCGGTGGG GCCGGCGGGG CCGGTGGAAC CGGCCTTGTT




300













GGTGGCGACG GCGGGGCCGG TGGGGCCGGC GGGACCGGCG GACTGCTGGC CGGGCTGATC




360













GGTGCCGGCG GAGGTCACGG CGGGACCGGC GGGCTCAGCA CTAATGGCGA CGGCGGGGTT




420













GGCGGGGCCG GCGGGAATGC CGGAATGCTC GCCGGGCCGG GCGGCGCCGG CGGAGCCGGC




480













GGTGACGGCG AAAACCTGGA CACCGGTGGG GACGGCGGGG CCGGCGGTAG CGCAGGGCTG




540













CTGTTCGGCA GCGGCGGCGC CGGCGGCGCC GGCGGATTTG GTTTCCTCGG TGGGGACGGC




600













GGGGCCGGTG GCAACGCCGG GCTGCTGTTG TCCAGCGGCG GGGCCGGCGG GTTCGGCGGG




660













TTCGGCACCG CCGGTGGGGT CGGTGGGGCC GGCGGCAATG CCGGCTGGCT GGGCTTCGGC




720













GGGGCCGGGG GCATCGGCGG AATCGGCGGT AACGCTAACG GGGGCGCCGG TGGGAACGGC




780













GGCACCGGCG GTCAGTTATG GGGTAGCGGC GGCGCCGGCG TCGAAGGCGG CGCAGCCTTA




840













AGCGTCGGCG ACACCGGCGG GGCCGGTGGC GTCGGCGGCA GCGCCGGGCT GATCGGCACC




900













GGCGGCAACG GCGGCAACGG CGGCACCGGC GCCAACGCCG GCAGCCCCGG AACCGGCGGC




960













GCCGGCGGGT TGCTGCTGGG CCAAAACGGG CTCAACGGGT TGCCGTAGCC GGGCGGCACG




1020 













GCATGGCTTC CGGGCGTCAA CCACTCGCCG GTGATGCAGA TCGGCTGCGG AGCGGGCCGC




1080 













CAAAATGGGG GCCGCCGCGC CAGGTATCTC GGCGAAGATC CCCGGCGCTC GAGCGCTTTG




1140 













TCAGAGGCCC GTCGCGGGTC GTCGTGACGA CGGCTATCCG GGCGGTGCGG GTTTCGCGGC




1200 













GCGCCCTGTG CCCGGCACCG CCGCCCGTTT GTCGGCAACG CCGCCGCGAC CCGTGAGCCG




1260 













TCCAGCAGCT GGCGCCTGCG




1280 











Polynucleotides of interest have been defined by the inventors as useful detection tools in order to differentiate


M. tuberclosis


from


M. bovis


BCG. Such polynucleotides are contained in the 45 aminoacid length coding sequence that is present in


M. bovis


BCG but absent from


M. tuberclosis


. This polynucleotide has a sequence beginning (5′ end) at the nucleotide at position nt 729 of the sequence SEQ ID N


o


4 and ending (3′ end) at the nucleotide in position nt 863 of the sequence SEQ ID N


o


4.




Thus, part of the present invention is also a polynucleotide which is chosen among the following group of polynucleotides:




a) A polynucleotide comprising at least 8 consecutive nucleotides the following nucleotide sequence SEQ ID N


o


5:














GGGCATCGGC GGAATCGGCG GTAACGCTAA CGGGGGCGCC GGTGGGAACG GCGGCACCGG




 60














CGGTCAGTTA TGGGGTAGCG GCGGCGCCGG CGTCGAAGGC GGCGCAGCCT TAAGCGTCGG




120













CGACACC




127











b) A polynucleotide which sequence is fully complementary to the sequence of the polynucleotide defined in a);




c) A polynucleotide that hybridizes under stringent hybridization conditions with the polynucleotide defined in a) or with the polynucleotide defined in b).




The stringent hybridization conditions for the purpose of defining the above disclosed polynucleotide are defined herein before in the specification.




The invention also provides for a BAC-based


Mycobacterium tuberculosis


strain H37Rv genomic DNA library that has been deposited in the Collection Nationale de Cultures de Microorganismes on Nov. 19, 1997 under the accession number I-1945.




A further object of the invention consists in a recombinant BAC vector which is choosen among the group consisting of the recombinant BAC vectors belonging to the BAC-based DNA library I-1945.




Generally, a recombinant BAC vector of interest may be choosen among the following set or group of BAC vectors contained in the BAC-based DNA library I-1945: Rv101; Rv102; Rv103; Rv104; Rv105; Rv106; Rv107; Rv108; Rv109; Rv10; Rv110; Rv111; Rv112; Rv113; Rv114; Rv115; Rv116; Rv117; Rv118; Rv119; Rv11; Rv120; Rv121; Rv122; Rv123; Rv124; Rv126; Rv127; Rv128; Rv129; Rv130; Rv132; Rv134; Rv135; Rv136; Rv137; Rv138; Rv139; Rv13; Rv140; Rv141; Rv142; Rv143; Rv144; Rv145; Rv146; Rv147; Rv148; Rv149; Rv14; Rv150; Rv151; Rv152; Rv153; Rv154; Rv155; Rv156; Rv157; Rv159; Rv15; Rv160; Rv161; Rv162; Rv163; Rv164; Rv165; Rv166; Rv167; Rv169; Rv16; Rv170; Rv171; Rv172; Rv173; Rv174; Rv175; Rv176; Rv177; Rv178; Rv179; Rv17; Rv180; Rv181; Rv182; Rv183; Rv184; Rv185; Rv186; Rv187; Rv188; Rv18; Rv190; Rv191; Rv192; Rv193; Rv194; Rv195; Rv196; Rv19; Rv1; Rv201; Rv204; Rv205; Rv207; Rv209; Rv20; Rv214; Rv215; Rv217; Rv218; Rv219; Rv21; Rv220; Rv221; Rv222; Rv223; Rv224; Rv225; Rv226; Rv227; Rv228; Rv229; Rv22; Rv230; Rv231; Rv232; Rv233; Rv234; Rv235; Rv237; Rv240; Rv241; Rv243; Rv244; Rv245; Rv246; Rv247; Rv249; Rv24; Rv251; Rv252; Rv253; Rv254; Rv255; Rv257; Rv258; Rv259; Rv25; Rv260; Rv261; Rv262; Rv263; Rv264; Rv265; Rv266; Rv267; Rv268; Rv269; Rv26; Rv270; Rv271; Rv272; Rv273; Rv274; Rv275; Rv276; Rv277; Rv278; Rv279; Rv27; Rv280; Rv281; Rv282; Rv283; Rv284; Rv285; Rv286; Rv287; Rv288; Rv289; Rv28; Rv290; Rv291; Rv292; Rv293; Rv294; Rv295; Rv296; Rv29; Rv2; Rv301; Rv302; Rv303; Rv304; Rv306; Rv307; Rv308; Rv309; Rv30; Rv310; Rv311; Rv312; Rv313; Rv3l4; Rv315; Rv316; Rv317; Rv318; Rv319; Rv31; Rv32; Rv322; Rv327; Rv328; Rv329; Rv32; Rv330; Rv331; Rv333; Rv334; Rv335; Rv336; Rv337; Rv338; Rv339; Rv33; Rv340; Rv341; Rv343; Rv344; Rv346; Rv347; Rv348; Rv349; Rv34; Rv350; Rv351; Rv352; Rv353; Rv354; Rv355; Rv356; Rv357; Rv358; Rv359; Rv35; Rv360; Rv361; Rv363; Rv364; Rv365; Rv366; Rv367; Rv368; Rv369; Rv36; Rv370; Rv371; Rv373; Rv374; Rv375; Rv376; Rv377; Rv378; Rv379; Rv37; Rv381; Rv382; Rv383; Rv384; Rv385; Rv386; Rv387; Rv388; Rv389; Rv38; Rv390; Rv391; Rv392; Rv393; Rv396; Rv39; Rv3; Rv40; Rv42; Rv413; Rv414; Rv415; Rv416; Rv417; Rv418; Rv419; Rv41; Rv42; Rv43; Rv45; Rv46; Rv47; Rv48; Rv49; Rv4; Rv50; Rv51; Rv52; Rv53; Rv54; Rv55; Rv57; Rv58; Rv59; Rv5; Rv60; Rv61; Rv62; Rv63; Rv64; Rv65; Rv66; Rv67; Rv69; Rv6; Rv70; Rv71; Rv72; Rv73; Rv74; Rv75; Rv76; Rv77; Rv78; Rv79; Rv80; Rv81; Rv82; Rv83; Rv84; Rv85; Rv86; Rv87; Rv88; Rv89; Rv8; Rv90; Rv92; Rv94; Rv95; Rv96; Rv9.




The end sequences of the polynucleotide inserts of each of the above clones corresponding respectively to the sequences adjacent to the T7 promoter and to the Sp6 promoter on the BAC vector are shown in Table 3.




It has been shown by the inventors that the minimal overlapping set of BAC vectors of the BAC-based DNA library I-1945 contains 68 unique BAC clones and practically spans almost the whole H37Rv chromosome with the exception of a single gap of approximately 150 kb.




More specifically, a recombinant BAC vector of interest is choosen among the following set or group of BAC vectors from the BAC-based DNA library I-1945, the location of which vector DNA inserts on the chromosome of


M. tuberclosis


is shown in FIG.


3


: Rv234; Rv351, Rv166; Rv35; Rv415; Rv404; Rv209; Rv272; Rv30; Rv228; Rv233; Rb38; Rv280; Rv177; Rv48; Rv374; Rv151; Rv238; Rv156; Rv92; Rv3; Rv403; Rv322; Rv243; Rv330; Rv285; Rv233; Rv219; Rv416; Rv67; Rv222; Rv149; Rv279; Rv87; Rv273; Rv266; Rv25; Rv136; Rv4l4; Rv13; Rv289; Rv60; Rv104; Rv5; Rv165; Rv215; Rv329; Rv240; Rv19; Rv74; Rv411; Rv167; Rv56; Rv80; Rv164; Rv59; Rv313; Rv265; Rv308; Rv220; Rv258; Rv339; Rv121; Rv419; Rv418; Rv45; Rv217; Rv134; Rv17; Rv103; Rv21; Rv22; Rv2; Rv270; Rv267; Rv174; Rv257; Rv44; Rv71; Rv7; Rv27; Rv191; Rv230; Rv128; Rv407; Rv106; Rv39; Rv255; Rv74; Rv355; Rv268; Rv58; Rv173; Rv264; Rv417; Rv401; Rv144; Rv302; Rv81; Rv163; Rv281; Rv221; Rv420; Rv175; Rv86; Rv412; Rv73; Rv269; Rv214; Rv287; Rv42; Rv143.




The polynucleotides disclosed in Table 3 may be used as probes in order to select a given clone of the BAC DNA library I-1945 for further use.




The invention also provides for a BAC-based


Mycobacterium bovis


strain Pasteur genornic DNA library that has been deposited in the Collection Nationale de Cultures de Microorganismes on Jun. 30, 1998 under the accession number I-2049.




A further object of the invention consists in a recombinant BAC vector which is chosen among the group consisting of the recombinant BAC vectors belonging to the BAC-based DNA library I-2049. This DNA library contains approximately 1600 clones. The average insert size is estimated to be 80 kb.




Generally, a recombinant BAC vector of interest may be chosen among the following set or group of BAC vectors contained in the BAC-based DNA library I-2049: X0001; X0002; X0003; X0004; X0006; X0007; X0008; X0009; X0010; X0012; X0013; X0014; X0015; X0016; X0017; X0018; X0019; X0020; X0021; X0175.




The end sequences of the polynucleotide inserts of each of the above clones corresponding respectively to the sequences adjacent to the T7 promoter and to the Sp6 promoter on the BAC vector are shown in Table 4.




The polynucleotides disclosed in Table 4 may be used as probes in order to select a given clone of the BAC DNA library I-2049 for further use.




Are also part of the invention the polynucleotide inserts that are contained in the above described BAC vectors, that are useful as primers or probes.




These polynucleotides and nucleic acid fragments may be used as primers for use in amplification reactions, or as nucleic probes.




PCR is described in the U.S. Pat. No. 4,683,202. The amplified fragments may be identified by an agarose or a polyacrylamide gel electrophoresis, or by a capillary electrophoresis or alternatively by a chromatography technique (gel filtration, hydrophobic chromatography or ion exchange chromatography). The specificity of the amplification may be ensured by a molecular hybridization using, for example, one of the initial primers as nucleic probes.




Amplified nucleotide fragments are used as probes in hybridization reactions in order to detect the presence of one polynucleotide according to the present invention or in order to detect mutations in the genome of the given mycobacterium of interest, specifically a mycobacterium belonging to the


Mycobacterium tuberculosis


complex and more specifically


Mycobacterium tuberculosis


and


Mycobacterium bovis


BCG.




Are also part of the present invention the amplified nucleic fragments (<<amplicons>>) defined herein above.




These probes and amplicons may be radioactively or non-radioactively labeled, using for example enzymes or fluorescent compounds.




Other techniques related to nucleic acid amplification may also be used and are generally preferred to the PCR technique.




The Strand Displacement Amplification (SDA) technique (Walker et al., 1992) is an isothermal amplification technique based on the ability of a restriction enzyme to cleave one of the strands at his recogntion site (which is under a hemiphosphorothioate form) and on the property of a DNA polymerase to initiate the synthesis of a new strand from the 3′OH end generated by the restriction enzyme and on the property of this DNA polymerase to displace the previously synthesized strand being localized downstream. The SDA method comprises two main steps:




a) The synthesis, in the presence of dCTP-alpha-S, of DNA molecules that are flanked by the restriction sites that may be cleaved by an appropriate enzyme.




b) The exponential amplification of these DNA molecules modified as such, by enzyme cleavage, strand displacement and copying of the displaced strands. The steps of cleavage , strand displacement and copy are repeated a sufficient number of times in order to obtain an accurate sensitivity of the assay.




The SDA technique was initially realized using the restriction endonuclease HindIII but is now generally practised with an endonuclease from


Bacillus stearothermophilus


(BSOBI) and a fragment of a DNA polymerase which is devoid of any 5′3′exonuclease activity isolated from


Bacilllus cladotenox


(exo-Bca) [=exo-minus-Bca]. Both enzymes are able to operate at 60° C. and the system is now optimized in order to allow the use of dUTP and the decontamination by UDG. When unsing this technique, as described by Spargo et al. in 1996, the doubling time of the target DNA is of 26 seconds and the amplification rate is of 10


10


after an incubation time of 15 min at 60° C.




The SDA amplification technique is more easy to perform than PCR (a single thermostated waterbath device is necessary) and is faster that the other amplification methods.




Thus, another object of the present invention consists in using the nucleic acid fragments according to the invention (primers) in a method of DNA or RNA amplification according to the SDA technique. For performing SDA, two pairs of primers are used: a pair of external primers (B1, B2) consisting of a sequence specific for the target polynucleotide of interest and a pair of internal primers (S1, S2) consisting of a fusion oligonucleotide carrying a site that is recognized by a restriction endonuclease, for example the enzyme BSOBI.




The operating conditions to perform SDA with such primers are described in Spargo et al, 1996.




The polynucleotides of the invention and their above described fragments, especially the primers according to the invention, are useful as technical means for performing different target nucleic acid amplification methods such as:




TAS (Transcription-based Amplification System), described by Kwoh et al. in 1989;




SR (Self-Sustained Sequence Replication), described by Guatelli et al. in 1990.




NASBA (Nucleic acid Sequence Based Amplification), described by Kievitis et al. in 1991.




TMA (Transcription Mediated Amplification).




The polynucleotides according to the invention are also useful as technical means for performing methods for amplification or modification of a nucleic acid used as a probe, such as:




LCR (Ligase Chain Reaction), described by Landegren et al. in 1988 and improved by Barany et al. in 1991 who employ a thermostable ligase.




RCR (Repair Chain Reaction) described by Segev et al. in 1992.




CPR (Cycling Probe Reaction), described by Duck et al. in 1990.




Q-beta replicase reaction, described by Miele et al. in 1983 and improved by Chu et al. in 1986, Lizardi et al. in 1988 and by Burg et al. and Stone et al. in 1996.




When the target polynucleotide to be detected is a RNA, for example a mRNA, a reverse transcriptase enzyme will be used before the amplification reaction in order to obtain a cDNA from the RNA contained in the biological sample. The generated cDNA is subsequently used as the nucleic acid target for the primers or the probes used in an amplification process or a detection process according to the present invention.




The non-labeled polynucleotides or oligonucleotides of the invention may be directly used as probes. Nevertheless, the polynucleotides or oligonucleotides are generally labeled with a radioactive element (


32


P,


35


S,


3


H,


125


I or by a non-isotopic molecule (for example, biotin, acetylaminofluorene, digoxigenin, 5-bromodesoxyuridin, fluorescein) in order to generate probes that are useful for numerous applications.




Examples of non-radioactive labeling of nucleic acid fragments are described in the french patent N


o


FR-7810975 or by Urdea et al. or Sanchez-Pescador et al., 1988.




In the latter case, other labeling techniques may be also used such as those described in the french patents FR-2,422,956 and 2,518,755. The hybridization step may be performed in diffrent ways (Matthews et al., 1988). The more general method consists of immobilizing the nucleic acid that has been extracted from the biological sample onto a substrate (nitrocellulose, nylon, polystyrene) and then to incubate, in defined conditions, the target nucleic acid with the probe. Subsequently to the hybridization step, the excess amount of the specific probe is discarded and the hybrid molecules formed are detected by an appropriate method (radioactivity, fluorescence or enzyme activity measurement).




Advantageously, the probes according to the present invention may have structural characteristics such that they allow the signal amplification, such structural characteristics being, for example, branched DNA probes as those described by Urdea et al. in 1991 or in the European patent N


o


EP-0225,807 (Chiron).




In another advantageous embodiment of the probes according to the present invention, the latters may be used as <<capture probes>>, and are for this purpose immobilized on a substrate in order to capture the target nucleic acid contained in a biological sample. The captured target nucleic acid is subsequently detected with a second probe which recognizes a sequence of the target nucleic acid which is different from the sequence recognized by the capture probe.




The oligonucleotide probes according to the present invention may also be used in a detection device comprising a matrix library of probes immobilized on a substrate, the sequence of each probe of a given length being localized in a shift of one or several bases, one from the other, each probe of the matrix library thus being complementary to a distinct sequence of the target nucleic acid. Optionally, the substrate of the matrix may be a material able to act as an electron donor, the detection of the matrix poisitons in which an hybridization has occurred being subsequently determined by an electronic device. Such matrix libraries of probes and methods of specific detection of a targer nucleic acid is described in the European patent application N


o


EP-0713,016 (Affymax technologies) and also in the U.S. Pat. No. 5,202,231 (Drmanac).




Since almost the whole length of a mycobacterial chromososme is covered by a BAC-based genomic DNA libraries according to the present invention (i.e. 97% of the


M. tuberculosis


chromosome is covered by the BAC library I-1945), these DNA libraries will play an important role in a plurality of post-genomic applications, such as in mycobacterial gene expression studies where the canonical set of BACs could be used as a matrix for hybridization studies. Probing such matrices with cDNA probes prepared from total mRNA will uncover genetic loci induced or repressed under different physiological conditions (Chuang et al., 1993; Trieselmann et al., 1992). As such, the H37Rv BAC library represents a fundamental resource for present and future genomics investigations.




The BAC vectors or the polynucleotide inserts contained therein may be directly used as probes, for example when immobilized on a substrate such as described herein before.




The BAC vectors or their polynucleotide inserts may be directly asdorbed on a nitrocellulose membrane, at predetermined locations on which one or several polynucleotides to be tested are then put to hybridize therewith.




Preferably, a collection of BAC vectors that spans the whole genome of the mycobacteriurn under testing will be immobilized, such as, for example, the set of 68 BAC vectors of the I-1945 DNA library that is described elsewhere in the specification and shown in FIG.


3


.




The immobilization and hybridization steps may be performed as described in the present Materials and Methods Section.




As another illustrative embodiment of the use of the BAC vectors of the invention as polynucleotide probes, these vectors may be useful to perform a transcriptional activity analysis of mycobacteria growing in different environmental conditions, for example under conditions in which a stress response is expected, as it is the case at an elevated temperature, for example 40° C.




In this specific embodiment of the invention, Genescreen membranes may be used to immobilize the restriction endonuclease digests (HindIII digests for the BAC DNA library I-1945) of the BAC vectors by tranfer from a gel (Trieselmann et al., 1992).




Alternatively, the BAC vectors may be immobilized for dot blot experiments as follows. First, the DNA concentration of each BAC clone is determined by hybridization of blots of clone DNAs and of a BAC vector concentration standard with a BAC vector specific DNA probe. Hybridization is quantified by the Betascope 603 blot analyzer (Betagen Corp.), which colects beta particles directly from the blot with high efficiency. Then, 0.5 μg of each clone DNA is incubated in 0.25 M NaOH and 10 mM EDTA at 65° C. for 60 min to denature the DNA and degrade residual RNA contaminants. By using a manifold filtration system (21 by 21 wells), each clone DNA is blotted onto a GeneScreen Plus nylon membrane in the alkaline solution. After neutralization, the blots are baked at 85° C. for 2 h under vacuum. Positive and negative controls are added when necessary. In order to perform this procedure, it may be referred to the article of Chuang et al. (1993).




For RNA extractions, cells grown in a suitable volume of culture medium may, for example, be immediately mixed with an equal volume of crushed ice at −70° C. and spun at 4° C. in a 50 ml centrifugation tube. The cell pellet is then suspended in 0.6 ml of ice-cold buffer (10 mM KCl, 5 mM MgCl, 10 mM Tris; pH 7.4) and then immediately added to 0.6 ml of hot lysis buffer (0.4 M NaCl, 40 mM EDTA, 1% beta-mercaptoethanol, 1% SDS, 20 mM Tris; pH 7.4) containing 100 μl of water saturated phenol. This mixture is incubated in a boiling water bath for 40 s. The debris are removed by centrifugation. The supernatant is extracted with phenol-chloroform five times, ethanol precipitated, and dried. The dried RNA pellet is dissolved in water before use.




Then labeled total cDNA may be prepared by the following method. The reaction mixture contains 15 μg of the previously prepared total RNA, 5 μg of pd(N


6


) (random hexamers from Pharmacia Inc.), 0.5 mM DATP, 0.5 mM dGTP and 0.5 mM DTTP, 5 μM dCTP, 100 μCi of [α-


32


P]dCTP (3,000 Ci/mmol), 50 mM Tris-HCl (pH 8.3), 6 mM MgCl


2


, 40 mM Kcl, 0.5 U of avian myeloblastosis virus reverse transcriptase (Life Science Inc.) in a total volume of 50 μl. The reaction is allowed to continue overnight at room temperature. EDTA and NaOH are then added to final concentrations of 50 mM and 0.25 M, respectively, and the mixture is incubated at 65° C. for 30 min to degrade the RNA templates. The cDNA is then ready to use after neutralization by adding Hcl and Tris buffer.




The hybridization step may be performed as described by Chuang et al. (1993) and briefly disclosed hereinafter. The DNA dot blot is hybridized to


32


P-labeled total cDNA in a solution containing 0.1% polyvinylpyrrolidone, 0.1% Ficoll, 0.1% sodium Pp


i


, 0.1% bovine serum albumin, 0.5% SDS, 100 mM NaCl, and 0.1 mM sodium citrate, pH 7.2, at 65° C. for 2 days and then washed with a solution containing 0.1% SDS, 100 mM NaCl, and 10 mM Na-citrate, pH 7.2. The same dot blot is used for hybridization with both control and experimental cDNAs, with an alkaline probe stripping procedure (soaked twice in 0.25M NaOH-0.75 M NaCl at room temperature, 30 min each, neutralized, and completely dried at 65° C. for at least 30 min) between the two hybridizations. Quantification may be done with the Betascope 603 blot analyzer (Betagen Corp.).




As it flows from the above technical teachings, another object of the invention consists in a method for detecting the presence of mycobateria in a biological sample comprising the steps of:




a) bringing into contact the recombinant BAC vector or a purified polynucleotide according to the invention with a biological sample.




b) detecting the hybrid nucleic acid molecule formed between said purified polynucleotide and the nucleic acid molecules contained within the biological sample.




The invention further deals with a method for detecting the presence of mycobacteria in a biological sample comprising the steps of:




a) Bringing into contact the recombinant BAC vector or a purified polynucleotide according to the invention that has been immobilized onto a substrate with a biological sample.




b) Bringing into contact the hybrid nucleic acid molecule formed between said purified polynucleotide and the nucleic acid contained in the biological sample with a labeled recombinant BAC vector or a polynucleotide according to the invention, provided that said polynucleotide and polynucleotide of step a) have non-overlapping sequences.




Another object of the invention consists in a method for detecting the presence of mycobacteria in a biological sample comprising the steps of:




a) Bringing into contact the nucleic acid molecules contained in the biological sample with a pair of primers according to the invention.




b) Amplifying said nucleic acid molecules;




d) detecting the nucleic acid fragments that have been amplified, for example by gel electrophoresis or with a labeled polynucleotide according to the invention.




In one specific embodiment of the above detection and/or amplification methods, said methods comprise an additional step wherein before step a), the nucleic acid molecules of the biological sample have been made available to a hybridization reaction.




In another specific embodiment of the above detection methods, said methods comprise an additional step, wherein, before the detection step, the nucleic acid molecules that are not hybridized with the immobilized purified polynucleotide are removed.




Also part of the invention is a kit for detecting mycobacteria in a biological sample comprising:




a) A recombinant BAC vector or a purified polynucleotide according to the invention;




b) Reagents necessary to perform a nucleic acid hybridization reaction.




The invention also pertains to a kit for detecting a mycobacteria in a biological sample comprising:




a) A recombinant BAC vector or a purified polynucleotide according to the invention that is immobilized onto a substrate.




b) Reagents necessary to perform a nucleic acid hybridization reaction.




c) A purified polynucleotide according to the invention which is radioactively or non-radioactively labeled, provided that said polynucleotide and the polynucleotide of step a) have non-overlapping sequences.




Moreover, the invention provides for a kit for detecting mycobacteria in a biological sample comprising:




a) A pair of purified primers according to the invention;




b) Reagents necessary to perform a nucleic acid amplification reaction;




c) Optionally, a purified polynucleotide according to the invention useful as a probe.




The invention embraces also a method for detecting the presence of a genomic DNA, a cDNA or a mRNA of mycobacteria in a biological sample, comprising the steps of:




a) Bringing into contact the biological sample with a plurality of BAC vectors according to the invention or purified polynucleotides according to the invention, that are immobilized on a substrate;




b) Detecting the hybrid complexes formed.




The invention also provides a kit for detecting the presence of genomic DNA, cDNA or mRNA of a mycobacterium in a biological sample, comprising:




a) A substrate on which a plurality of BAC vectors according to the invention or purified polynucleotides according to the invention have been immobilized;




b) Optionally, the reagents necessary to perform the hybridization reaction.




Additionally, the recombinant BAC vectors according to the invention and the polynucleotide inserts contained therein may be used for performing detection methods based on <<molecular combing>>. Said methods consist in methods for aligning macromolecules, especially DNA and are applied to processes for detecting, for measuring intramolecular distance, for separating and/or for assaying a macromolecule, especially DNA in a sample.




These <<molecular combing>> methods are simple methods, where the triple line S/A/B (meniscus) resulting form the contact between a solvent A and the surface S and a medium B is caused to move on the said surface S, the said macromolecules (i.e. DNA) having a part, especially an end, anchored on the surface S, the other part, especially the other end, being in solution in the solvent A. These methods are particularly fully described in the PCT Application n


o


PCT/FR 95/00165 files on Feb. 11, 1994 (Bensimon et al.).




When performing the <<molecular combing>> method with the recombinant BAC vectors according to the inventions or their polynucleotide inserts, the latters may be immobilized (<<anchored>>) on a suitable substrate and aligned as described in the PCT Application No. PCT/FR 95/00165, the whole teachings of this PCT Application being herein incorporated by reference. Then, polynucleotides to be tested, preferably under the form of radioactively or non radioactively labeled polynucleotides, that may consist of fragments of genomic DNA, cDNA etc. are brought into contact with the previously aligned polynucleotides according to the present invention and then their hybridization position on the aligned DNA molecules is determined using any suitable means including a microscope or a suitable camera device.




Thus, the present invention is also directed to a method for the detection of the presence of a polynucleotide of mycobacterial origin in a biological sample and/or for physical mapping of a polynucleotide on a genomic DNA, said method comprising:




a) Aligning at least one polynucleotide contained in a recombinant BAC vector according to the invention on the surface of a substrate;




b) Bringing into contact at least one polynucleotide to be tested with the substrate on which the at least one polynucleotide of step a) has been aligned;




c) detecting the presence and/or the location of the tested polynucleotide on the at least one aligned polynucleotide of step a).




The invention finally provides for a kit for performing the above method, comprising:




a) a substrate whose surface has at least one polynucleotide contained in a recombinant BAC vector according to the invention,




b) optionally, reagents necessary for labeling DNA;




c) optionally, reagents necessary for performing a hybridization reaction.




In conclusion, it may be underlined that the alliance of such BAC-based approaches such as described in the present specification to the advances in comparative genomics by the availability of an increased number of complete genomes, and the rapid increase of well-characterized gene products in the public databases, will allow the one skilled in the art an exhaustive analysis of the mycobacterial genome.




MATERIALS AND METHODS




1. DNA-preparation. Preparation of


M. tuberclosis


H37Rv DNA in agarose plugs was conducted as previously described (Canard et al., 1989; Philipp et al., 1996b). Plugs were stored in 0.2 M EDTA at 4 C and washed 3 times in 0.1% Triton X-100 buffer prior to use.




2. BAC vector preparation. pBeloBAC11 was kindly provided by Dr. Shizuya, Department of Biology, California Institute of Technology (Pasadena, Calif.). The preparation followed the description of Woo et al., 1994 (Woo et al., 1994).




3. Partial digestion with HindIII. Partial digestion was carried out on plugs, each containing approximately 10 μg of high molecular weight DNA, after three one hour equilibration steps in 50 ml of HindIII 1×digestion buffer (Boehringer Mannheim, Mannheim, Germany) plus 0.1% Triton X-100. The buffer was then removed and replaced by imliplug of ice-cold HindIII enzyme buffer containing 20 units of HindIII (Boehringer). After two hours incubation on ice, the plugs were transferred to a 37° C. water bath for 30 minutes. Digestions were stopped by adding 500 μl of 50 mM EDTA (pH 8.0).




4. Size selection. The partially digested DNA was subjected to contour-clamped homogenous electric field (CHEF) electrophoresis on a 1% agarose gel using a BioRad DR III apparatus (BioRad, Hercules, Calif.) in 1×TAE buffer at 13° C., with a ramp from 3 to 15 seconds at 6 V/cm for 16 hours. Agarose slices from 25 to 75 kb, 75 to 120 kb and 120 to 180 kb were excised from the gel and stored in TE at 4° C.




5. Ligation and transformation. Agarose-slices containing fractions from 25 to 75 kb, 75 to 120 kb and 120 to 180 kb were melted at 65° C. for 10 minutes and digested with Gelase (Epicentre Technologies, Madison, Wis.), using 1 unit per 100 μl gel-slice. 25-100 ng of the size-selected DNA was then ligated to 10 ng of HindIII digested, dephosphorylated pBeloBAC11 in a 1:10 molar ratio using 10 units of T4 DNA ligase (New England Biolabs, Beverly, Mass.) at 16° C. for 20 hours. Ligation mixtures were heated at 65° C. for 15 minutes, then drop-dialysed against TE using Millipore VS 0.025 mM membranes (Millipore, Bedford, Mass.). Fresh electrocompetent


E. coli


DH 10B cells (Sheng et al., 1995) were harvested from 200 ml of a mid-log (OD


550


=0.5) culture grown in SOB medium. Cells were washed three times in ice-cold water, and finally resuspended in ice-cold water to a cell density of 10


11


cells/ml (OD


550


=150). 1 μl of the ligation-mix was used for electroporation of 30 μl of electrocompetent DH10B


E. coli


using a Eurogentec Easyject Plus electroporator (Eurogentec, Seraing, Belgium), with settings of 2.5 kV, 25 μF, and 99 ½, in 2 mm wide electroporation cuvettes. After electroporation, cells were resuspended in 600 μl of SOC medium, allowed to recover for 45 minutes at 37° C. with gentle shaking, and then plated on LB agar containing 12.5 μg/ml chloramphenicol (CM), 50 μg/ml X-gal, and 25 μg/ml IPTG. The plates were incubated overnight and recombinants (white colonies) were picked manually to 96 well plates. Each clone was inoculated 3 times (2×200 μl and 1×100 μl of 2YT/12.5 μg/ml CM per clone) and incubated overnight. One of the microtiter plates, containing 100 μl culture per well, was maintained as a master plate at −80° C. after 100 ml of 80% glycerol were added to each well, while minipreps (Sambrook et al., 1989) were prepared from the remaining two plates to check for the presence of inserts. Clones containing inserts were then designated “Rv” clones, repicked from the master plate to a second set of plates for storage of the library at −80° C.




6. Preparation of DNA for sizing, direct sequencing and comparative genomics. A modified Bimboim and Doly protocol (Birnboim et al., 1979) was used for extraction of plasmid DNA for sequencing purposes. Each Rv clone was inoculated into a 50 ml Falcon polypropylene tube containing 40 ml of 2YT medium with 12.5 μg/ml of CM and grown overnight at 37° C. with shaking. Cells were harvested by centrifugation and stored at −20° C. The frozen pellet was resuspended in 4 ml of Solution A (50 mM glucose, 10 mM EDTA, 25 mM Tris, pH 8.0) and 4 ml of freshly prepared solution B (0.2 M NaOH, 0.2% SDS) was then added. The solution was gently mixed and kept at room temperature for 5 minutes before adding 4 ml of ice-cold solution C (3M Sodium Acetate, pH 4.7). Tubes were kept on ice for 15 min, and centrifuged at 10,000 rpm for 15 min. After isopropanol precipitation, the DNA pellet was dissolved in 600 μl RNase solution (15 mM Tris HCl pH 8.0, 10 μg/ml RNase A). After 30 minutes at 37° C. the DNA solution was extracted with chloroform:isoarnylalcohol (24:1) and precipitated from the aqueous phase using isopropanol. The DNA pellet was then rinsed with 70% ethanol, air-dried and dissolved in 30 μl distilled water. In general, DNA prepared by this method was clean and concentrated enough to give good quality results by automatic sequencing (at least 300 bp of sequence). For a few DNA preparations, an additional polyethylene glycol (PEG) precipitation step was necessary, which was performed as follows. The 30 μl of DNA solution were diluted to 64 μl, mixed gently and precipitated using 16 μl 4M NaCl and 80 μl of 13% PEG 8000. After 30 min on ice the tubes were centrifuged at 4° C., the pellet carefully rinsed with 70% ethanol, air-dried and diluted in 20 μl of distilled water.




7. Sizing of inserts. Insert sizes were determined by pulsed-field gel electrophoresis (PFGE) after cleavage with Dral (Promega). 100-200 ng of DNA was Dral-cleaved in 20 μl total reaction volume, following the manufacturer's recommendations, then loaded onto a 1% agarose gel and migrated using a pulse of 4 s for 15 h at 6.25 V/cm at 10° C. on an LKB-Pharmacia CHEF apparatus. Mid-range and low-range PFGE markers (New England Biolabs) were used as size standards. Insert sizes were estimated after ethidium bromide staining of gels.




8. Direct sequencing. For each sequencing reaction 7 μl BAC DNA (300-500 ng), 2 μl primer (2 μM), 8 μl reaction mix of the Taq DyeDeoxy Terminator cycle sequencing kit (Applied Biosystems) and 30 μl distilled water were used. After 26 cycles (96° C. for 30 sec; 56° C. for 15 sec; 60° C. for 4 min) in a thermocycler (MJ-research Inc., Watertown, Mass.) DNA was precipitated using 70 μl of 70% ethanol/0.5 mM MgCl


2


, centrifuged, rinsed with 70% ethanol, dried and dissolved in 2 μl of formamide/EDTA buffer. SP6 and T7 samples of 32 BAC clones were loaded onto 64 lane, 6% polyacrylamide gels and electrophoresis was performed on a Model 373A automatic DNA sequencer (Applied Biosystems) for 12 to 16 hours. The sequences of oligonucleotides used as primers are shown in Table 1.




9. DOP-PCR. As an alternate procedure we used partially degenerate oligonucleotides in combination with vector-specific (SP6 or T7) primers to amplify insert ends of BAC clones, following a previously published protocol for P1 clones (Liu et al., 1995). The degenerate primers Deg2, Deg3, Deg4, Deg6 (Table 1) gave the best results for selected amplification of insert termini.












TABLE 1









Primers used for PCRs and sequencing























Vector specific Primers for DOP PCR-first






amplification step:












SP6-BAC1:




AGT TAG CTC ACT CAT TAG GCA







(SEQ ID NO: 734)






T7-BAC1:




GGA TGT GCT GCA AGG CGA TTA







(SEQ ID NO: 735)


















Vector specific Primers (direct sequencing nested






primer for second PCR step)












SP6 Mid:




AAA CAG CTA TGA CCA TGA TTA CGC CAA







(SEQ ID NO: 736)






T7-Belo2:




TCC TCT AGA GTC GAC CTG CAG GCA







(SEQ ID NO: 737)


















Degenerate Primers:












Deg2:




TCT AGA NNN NNN TCC GGC







(SEQ ID NO: 738)






Deg3:




TCT AGA NNN NNN GGG CCC







(SEQ ID NO: 739)






Deg4:




CGT TTA AAN NNN NWA GGC CG







(SEQ ID NO: 740)






Deg6:




GGT ACT AGT NNN NNW TCC GGC







(SEQ ID NO: 741)











Primers used for the amplification of


M. bovis








DNA in polymorphic chromosomal region of Rv58:












Primer 1:




ACG ACC TCA TAT TCC GAA TCC C







(SEQ ID NO: 742)






Primer 2:




GCA TCT GTT GAG TAC GCA CTT CC







(SEQ ID NO: 743)














10. Screening by pooled PCR. To identify particular clones in the library which could not be detected by random end-sequencing of the 400 BAC clones, PCR-screening of DNA pools was performed. Primers were designed for regions of the chromosome where no BAC coverage was appearent using cosmid-or H37Rv whole genome shotgun sequences. Primers were designed to amplify approximately 400-500 bp. Ninety-six-well plates containing 200 μl 2YT/12.5 μg/ml CM per well were inoculated with 5 μl of −80° C. glycerol stock cultures each from the master plates and incubated overnight. The 96 clones of each plate were pooled by taking 20 μl of culture from each well and this procedure was repeated for 31 plates. Pooled cultures were centrifuged, the pellets were resuspended in sterile water, boiled for 5 minutes, centrifuged and the supernatants kept for PCRS. As an initial screening step, the 31 pools of a total of 2976 BACs, representing about two thirds of the library were tested for the presence of a specific clone using appropriate PCR primers. PCR was performed using 10 μl of supernatant, 5 μl of assay buffer (100 mM b-mercaptoethanol, 600 mM Tris HCl (pH 8.8), 20 mM MgCl


2


, 170 mM (NH


4


)


2


SO


4


), 5 μl of Dimethylsulfoxide (DMSO), 5 μl of dNTPs (20 mM), 5 μl of water, 10 μl primer (2 μM), 10 μl inverse primer (2 μM) and 0.2 units off aq DNA polymerase (Boehringer). 32 cycles of PCR (95° C. for 30 s, 55° C. for 1 min 30 s, 72° C. for 2 min) were performed after an initial denaturation at 95° C. 1 min. An extension step at 72° C. for 5 min finished the PCR. If a pool of 96 clones yielded an appropriate PCR product (FIG.


1


A), subpools were made to identify the specific clone. Subpools representative for lane A of a 96 well plate were made by pooling clones 1 to 12 from lane A into a separate tube. Subpools for lanes B to H were made in the same way. In addition, subpools of each of the 12 rows (containing 8 clones each) were made, so that for one 96 well plate, 20 subpools were obtained. PCR with these 20 subpools identified the specific clone (

FIG. 1B

, lower gel portion). If more than one specific clone was present among the 96 clones of one plate (

FIG. 1B

, upper gel portion), additional PCR reactions had to be performed with the possible candidates (data not shown).




11. Genomic comparisons. DNA from the BAC clone Rv58 was digested with the restriction endonucleases EcoRI and PvuII, and resolved by agarose gel electrophoresis at low voltage overnight (1.5 V/cm). DNA was transferred via the method of Southern to nitrocellulose membranes (Hybond C extra, Amersham) following standard protocols (Sambrook et al., 1989), then fixed to the membranes at 80° C. for 2 hours. The blot was hybridized with


32


P labelled total genomic DNA from


M. tuberclosis


H37Rv,


M. bovis


type strain (ATCC 19210) or


M. bovis


BCG Pasteur. Hybridization was performed at 37° C. overnight in 50% formamide hybridization buffer as previously described (Philipp et al., 1996b). Results were interpreted from the autoradiograms.




12. Computer analysis. Sequence data from the automated sequencer ABI373A were transferred as binary data to a Digital Alpha 200 station or Sun SparcII station and analysed using TED, a sequence analysis program from the Staden software package (Dear et al., 1991). Proof-read sequences were compared using the BLAST programs (Altschul et al., 1990) to the


M. tuberclosis


H37Rv sequence databases of the Sanger Centre, containing the collected cosmid sequences (TB.dbs) and whole-genome shotgun reads (TB_shotgun_all.dbs) (http://www.sanger.ac.uk/). In addition, local databases containing 1520 cosmid endsequences and the accumulating BAC endsequences were used to determine the exact location of end-sequenced BACs on the physical and genetic map. MycDB (Bergh et al., 1994) and public databases (EMBL, Genbank) were also used to compare new sequences, but to a lesser extent. The organization of the open reading frames (ORFs) in the polymorphic region of clone Rv58 was determined using the DIANA software established at the Sanger Centre.




EXAMPLES




Example 1




Construction of a pBeloBAC11 Library of


M. tuberclosis


H37Rv.




Partial HindIII fragments of H37Rv DNA in the size range of 25 to 180 kb were ligated into pBeloBAC11 and electroporated into strain


E. coli


DH10B. While cloning of fractions I (25 to 75 kb) and II (75 to 120 kb) gave approximately 4×10


4


transfornants (white colonies), cloning of fraction III (120 to 180 kb) repeatedly resulted in empty clones. Parallel cloning experiments using partial HindIII digests of human DNA resulted in stable inserts for all three fractions (data not shown), suggesting that the maximum size of large inserts in BAC clones is strongly dependent on the source of the DNA. Analysis of the clones for the presence of inserts revealed that 70% of the clones had an insert of the appropriate size while the remaining 30% of white colonies represented empty or lacZ′-mutated clones. Size determination of randomly selected, Dral-cleaved BACs via PFGE showed that the insert sizes ranged for the majority of the clones between 40 kb and 100 kb with an average size of 70 kb. Clones with inserts of appropriate size were designated with “Rv” numbers, recultured and stored at −80° C. for further use.




Example 2




Direct DNA Sequence Analysis of BACs.




To characterize the BAC clones, they were systematically subjected to insert termini sequencing. Two approaches, direct sequencing of BAC DNA and PCR with degenerate oligonucleotide primers (DOP), adapted to the high G+C content of mycobacterial DNA, were used. In a first screening phase, 50 BAC clones designated Rv1 to Rv50 were analysed using both methods in parallel. Except for two clones, where the sequences diverged significantly, the sequences obtained by the two methods only differed in length. Sequences obtained directly were on average about 350 bp long and for 95% of the clones both the SP6 and T7 endsequences were obtained at the first attempt. Sequences obtained by DOP-PCR were mostly shorter than 300 bp. For 40% of the BACs we obtained only very short amplicons of 50 to 100 base pairs from one end. In two cases the sequence obtained with the DOP-PCR differed from the sequences obtained by direct sequencing, and in these cases


E. coli


or vector sequences were amplified (data not shown). Taking the advantages and disadvantages of both methods into account, we decided to use direct termini sequencing for the systematic determination of the SP6 and T7 end-sequences.




Example 3




Representativity of the Library.




After having determined the end-sequences of 400 BACs a certain redundancy was seen. The majority of clones were represented at least 3 to 4 times. Maximum redundancy was seen in the vicinity of the unique ran operon, as 2.5% of the clones carried identical fragments that bridge the cosmids Y50 and Y130 (

FIG. 3

, approximate position at 1440 kb). The majority of clones with identical inserts appeared as two variants, corresponding to both possible orientations of the HindIII fragment in pBeloBAC11. This suggests that the redundancy was not the result of amplification during library construction, but due to the limited number of possible combinations of partial HindIII fragments in the given size-range of 25 to 120 kb. To detect rare BAC clones, a pooled PCR protocol was used. Primers were designed on the basis of the existing cosmid sequences and used to screen 31 pools of 96 BAC clones. When positive PCR products of the correct size were obtained, smaller subpools (of 8 or 12 clones each) of the corresponding pool were subsequently used to identify the corresponding clone (FIG.


1


). With this approach 20 additional BACs (Rv401-Rv420) were found for the regions where no BACs were found with the initial systematic sequencing approach. The endsequences of these BACs (Rv401-420) were determined by direct sequencing, which confirmed the predicted location of the clones on the chromosome. A 97% coverage of the genome of H37Rv with BAC clones was obtained. Only one region of 150 kb was apparently not represented in the BAC library as screening of all pools with several sets of specific primers did not reveal the corresponding clone. This was probably due to the fact that HindIII fragments of mycobacterial DNA larger than 110 kb are very difficult to establish in


E. coli


and that a HindIII fragment of ˜120 kb is present in this region of the chromosome (data not shown).




Example 4




Establishing a BAC Map.




Using all endsequence and shotgun-sequence data from the H37Rv genome sequencing project, most of the BAC clones could then be localized by sequence comparison on the integrated map of the chromosome of


M. tuberclosis


strain H37Rv (Philipp et al., 1996b) and an ordered physical map of the BAC-clones was established. PCR with primers from the termini sequences of selected BACs were used for chromosomal walking and confirmation of overlapping BACs (data not shown). The correct order of BACs on the map was also confirmed more recently, using 40,000 whole genome shotgun reads established at the Sanger Centre. In addition, pulsed-field gel electrophoresis of Dral digests of selected BACs was performed (

FIG. 2

) in order to see if the approximate fragment size and the presence or absence of DraI cleavage sites in the insert were consistent with the location of the BACs on the physical map (FIG.


3


). Comparison of the sequence-based BAC-map with the physical and genetic map, established by PFGE and hybridization experiments (Philipp et al., 1996b), showed that the two maps were in good agreement. The positions of 8 genetic markers previously shown on the physical and genetic map were directly confirmed by BAC-endsequence data (Table 2, FIG.


3


). The position of 43 from 47 Y-clones (91%) shown on the physical and genetic map, which were later shotgun sequenced, was confirmed by the BAC endsequences and shotgun sequence data. Four clones (Y63, Y180, Y251, and Y253) were located to different positions than previously thought and this was found to be due to book keeping errors or to chimeric inserts. Their present approximate location relative to the oric is shown in FIG.


3


: Y63 at 380 kb, Y63A at 2300 kb, Y180 at 2160 kb, Y251 at 100 kb, and Y253 at 2700 kb. A total of 48 BACs, covering regions of the chromosome, not represented by cosmids were then shotgun sequenced (Cole et al., 1997), and these are squared in FIG.


3


. No chimeric BACs were found, which is consistent with the observations of other research groups for other BAC libraries (Cai et al., 1995; Zimmer et al;, 1997). The absence of chimeric BACs was of particular importance for the correct assembly of the


M. tuberculosis


H37Rv sequence. The exact position of the BAC termini sequences on the chromosome will be available via the world wide web












TABLE 2











Identities of genetic markers previously shown on the integrated and






genetic map of H37Rv (Phlipp et al., 1996b) which showed perfect






sequence homology with BAC end sequences.
















BAC










end




Description of





GenBank






Locus




sequence




genetic marker




Organism




Accession n


o











apa




Rv163SP6




Secreted






M. tuberculosis






X80268








alanine-proline-rich








antigen






dnaJ,




Rv164T7




DnaJ hsp






M. leprae






M95576






dnaK






fop-A




Rv136T7




Fibronectin binding






M. tuberculosis






M27016








protein






polA




Rv401T7




DNA polymerase I






M. tuberculosis






L11920






ponA




Rv273T7




Penicillin binding






M. leprae






S82044








protein






pstC




Rv103T7




Putative






M. tuberculosis






Z48057








phosphate transport








receptor






recA




Rv415SP6




Homologous






M. tuberculosis






X58485








recombination






wag9




Rv35SP6




35-kDa antigen






M. tuberculosis






M69187














Example 5




Repetitive Endsequences.




Repetitive sequences can seriously confound mapping and sequence assembly. In the case of the BAC endsequences, no particular problems with repetitive sequences were observed. Although nine clones with one end in an IS1081 (Collins et al., 1991) sequence were identified, it was possible to correctly locate their position on the map using the sequence of the second terminus. Moreover, these BACs were used to determine the exact locations of IS1081 sequences on the map. Five copies of this insertion sequence, which harbors a HindIII cleavage site, were mapped on the previous physical and genetic map. In contrast, BAC endsequence data revealed an additional copy of IS1081 on the


M. tuberculosis


H37Rv chromosome. The additional copy was identified by six clones (Rv27, Rv118, Rv142, Rv160, Rv190, Rv371) which harbored an identical fragment linking Y50 to 1364 (

FIG. 3

, at ˜1380 kb). This copy of IS1081 was not found by previous hybridization experiments probably because it is located near another copy of IS1081, localized on the same DraI fragment Z7 and AsnI fragment U (

FIG. 3

, at ˜1140 kb). Furthermore, the position of a copy of IS1081 previously shown in DraI fragment Y1 (

FIG. 3

, at ˜1840 kb) had to be changed to the region of Y349 (

FIG. 3

, at ˜3340 kb) according to the endsequences of BAC Rv223. The positions of the four other IS1081 copies were confirmed by the sequence data and therefore remained unchanged. In total 6 copies of IS1081 were identified in the H37Rv genome in agreement with the findings of others (Collins et al., 1991).




In addition, a sequence of 1165 bp in length containing a HindIII site was found in two copies in the genome of H37Rv in different regions. The endsequences of BAC clones Rv48 and Rv374, covering cosmid Y164, as well as Rv419 and Rv45, that cover cosmid Y92, had perfect identity with the corresponding parts of this 1165 bp sequence (

FIG. 3

, at ˜3480 kb and 900 kb). Analysis of the sequence did not reveal any homology with insertion sequences or other repetitive elements. However, as each of the two locations showed appropriate BAC coverage, chimerism of the sequenced cosmids Y164 and Y92 can be ruled out as the probable cause.




Example 6




Using BAC Clones in Comparative Genomics.




The minimal overlapping set of BAC clones represents a powerful tool for comparative genomics. For example, with each BAC clone containing on average an insert of 70 kb, it should be possible to cover a 1 Mb section of the chromosome with 15 BAC clones. Restriction digests of overlapping clones can then be blotted to membranes, and probed with radiolabelled total genomic DNA from, for example,


M. bovis


BCG Pasteur. Restriction fragments that fail to hybridize with the


M. bovis


BCG Pasteur DNA must be absent from its genome, hence identifying polymorphic regions between


M. bovis


BCG Pasteur and


M. tuberclosis


H37Rv. The results of such an analysis with clone Rv58 (

FIG. 3

, at 1680 kb) are shown here. This clone covers a previously described polymorphic genomic region between


M. tuberclosis


and


M. bovis


BCG strains (Philipp et al., 1996a). EcoRI and PvuII digests from clone Rv58, fixed on nitrocellulose membranes, were hybridized with


32


P-labelled total genomic DNA from


M. tuberclosis


H37Rv,


M. bovis


(ATCC 19120), and


M. bovis


BCG Pasteur.

FIG. 4

presents the results of this analysis, where it is clear that several restriction fragments from clone Rv58 failed to hybridize with genomic DNA from either


M. bovis


or


M. bovis


BCG Pasteur. On the basis of the various missing restriction fragments, a restriction map of the polymorphic region was established and compared to the H37Rv sequence data. The localization of the polymorphism could therefore be estimated, and appropriate oligonucleotide primers (Table 1) were selected for the amplification and sequencing of the corresponding region in


M. bovis


. The alignment of


M. bovis


and


M. tuberculosis


H37Rv sequences showed that 12,732 bp were absent from the chromosomal region of the


M. bovis


type strain and


M. bovis


BCG Pasteur strain. The G+C content of the polymorphic region is 62.3 mol %, which is the same as the average genome G+C content of the


M. tuberclosis


genome, hence indicating that this region is not a prophage or other such insertion. Subsequent PCR studies revealed that this segment was also absent from the Danish, Russian, and Glaxo substrains of


M. bovis


BCG, suggesting that this polymorphism can be used to distinguish


M. bovis


from


M. tuberclosis


. Analysis of this sequence showed that 11 putative open reading frames (ORFS) are present in


M. tuberclosis


, corresponding to ORFs MTCY277.28 to MTCY277.38/accession number Z79701-EMBL Nucleotide Sequence Data Library (FIG.


5


). FASTA searches against the protein and nucleic acid databases revealed that the genes of this region may be involved in polysaccharide biosynthesis. Among these putative genes, the highest score was seen with ORF 6 (MCY277.33), whose putative product shows a 51.9% identity with GDP-D-Mannose dehydratase from


Pseudomonas aeruginosa


(accession number U18320-EMBL Nucleotide Sequence Data Library) in a 320 amino acid overlap. The novel


M. bovis


sequence of the polymorphic region was deposited under accession number AJ003103 in the EMBL Nucleotide Sequence Data Library.




As it appears from the teachings of the specification, the invention is not limited in scope to one or several of the above detailed embodiments; the present invention also embraces all the alternatives that can be performed by one skilled in the same technical field, without deviating from the subject or from the scope of the instant invention.












TABLE 3









End sequences of the polynucleotide inserts cloned in the named recombinant






BAC vectors contained in the I-1945


M. tuberculosis


H37Rv genomic DNA library.






RvXXXSP6 corresponds to the SP6 endsequence of the clone RvXXX;






RvXXXT7 corresponds to the T7 endsequence of the clone RvXXX.






RvXXXIS 1081 corresponds to a region located close to a copy of the IS1081






repetitive sequence (Insertion element)






The character <<->> denotes an uncertain base residue.

























Clone Rv101




::::::::::::::Rv101SP6.seq::::::::::::::








AATACTCAAGCTTGCCCAGCCGTCGATGACAAGAAATATGTCCGCAAAAGACTCAGCGGCCGACTTTTGCTCGCAGCTGGCGGTACCGCGCCACCGATTCTATGCCG




(SEQ ID NO. 6)







TGGTCGCGGAAAAATGCCTCCCGAAATCGCACGGCCGACTCCAGTTCGGCGAGCATCCGCGATGCCAGCTGCGGCTGCGCCCTGCCGGCCACGGCACCCACATGCG







GCAGTTCGTCCACCTGGGCCAGCGCCCCGCCGCCGAATTCCAAACAATAGAACTGCACCCGGCCCGCATCTGTGGGTAACAGCCAACGCCATGATCAGCGTCCGCAG







CGCGGTTGACTTGCCCGTTTGCGGTGCACCTACGAACGCGACATTGCCTGCGGCCCCGGACAAGTCGATCGTGCGCGGCACCGTGACTGCTCTAACGGGCGATTG







AAATTCCGAT







::::::::::::::Rv101T7.seq::::::::::::::







CCACCCGTGTAATTTGGGATGGGCAAAAAGGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTGGGCGGTTAGGGCTTCTCGCCGGGAAGGCCCGAAC




(SEQ ID NO. 7)







GTACGGCGTTTCAACACCTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGCTGGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGG







TAGTCGCCGCCCGGGCGGCTACACTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCCGACGCAACGGTTCCTACACCGCGATATGTTCGCCTCGCTGC







CCCGGTGGACCGGT






Clone Rv102




::::::::::::::Rv102SP6.seq::::::::::::::







AATACTCAAGCTTTCCGCCGATACCCGCCATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAGTGCGGATGATCGGGCCGCC




(SEQ ID NO. 8)







TACGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGG







CCTATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGGCGGAGACAAAAGTATCGCTAAGGTCACCGCGATCACCAACATGGTGATCGCAGCAATGTT







GCTAGTGATCTATCGCTCCGTAATTACCGCGGTTCT







::::::::::::::Rv102T7.seq::::::::::::::







GTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGG




(SEQ ID NO. 9)







ACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCGTTGACCGGGCGGATCGCGGTGATCGTCGA







TGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCGATCGGCCCAGACGACATC







GTGGCGAGATTCGCCGGGTACGCCGATGAGGTGGT






Clone Rv103




::::::::::::::Rv103SP6.seq::::::::::::::







AATACTCAAGCTTTCGGCGGAAACGGACACATTGCGAATATTGATGACAAAATAAAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAA




(SEQ ID NO. 10)







ATTCCAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATA







TGGCGAAAAACGGTCGCCGTTGCACGACATTAAATGTCACGGTATTGTAGATTAAAAAGATACCCAC







::::::::::::::Rv103T7.seq::::::::::::::







TGCTCCCGAAACCTGGGGTGTGCCTGCTCTGTATGCACGGCATACGGACATCCTTCCCCTGAGACCCGCGGTCGAACCAGCCACGTGTCCATCATAGNGGGTCAA




(SEQ ID NO. 11)







CCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGATCAAAACAGCTGGTCGGCCGTTAGGAACTGAATT







GAAACTCAACCGATTTGGTGCCGCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTGTCCGCCTGTGGTAACGACGACAATGTGACCGGGGGAGGTGCAACCACT







GGCCAGGCGTCGGCAAAGGTCGATTGCGGGGGGAAGAAGACACTCAAAGCCAGTGGGT






Clone Rv104




::::::::::::::Rv104SP6.seq::::::::::::::







ATACTCAAGCTTTGCCGACGAGCGGGCGATGTTGATGACGGGAAACCCCAGCGCACAACCGACGATTTTGGCGTAGCCGGCGGACGTCTGCTCGATTCCGATCAGG




(SEQ ID NO. 12)







TCGGCGCTCGCATCGAGCATGGCGCCGGCGACGGCTAGCAGCGATCCGCCGTCGTCGAGGAGCACGACACGAGCCGTACGCCCGGCCGTAAGCCGCGCCCAGGATT







CGGCGAAAAACCGTTCTACGTGGCGGGTGTACTGGGTGTCGAATGATTCGTGGGGTGCGTAGGCGTCGCTGCAATCGTCGACATAGATGCCGTCGGGCCGCATCGC







GTCGACAACTCCGGGTGAGTGGAATAGCACTTGCCGATCACCGCGACGTTGCGCGGATGAGGCCGAACCCGAATA







::::::::::::::Rv104T7.seq::::::::::::::







TCCTATGTCCCTGCCGAGCANGTGATCGAACGCGGTGACAGATTTGTCTATCCTGGACCTGACGGTGAGGTCGAAGTTTTCCAGGAATTCGGCAAAATCGGTAAGA




(SEQ ID NO. 13)







GCCTGAAGAATTCGGTATCGCCGGACGAAATCTGCGACGCATACGGGGGCATATACGCTTCGGGTTTACGAGATGTCGATGGGGCCGCTGGAGGCTTCACGTCCAT







GGGCCACAAAGGATGTTGTCGGCGCGTACCGTTTTCTGCAGCGGGTGTGGCGCTTGGTCG






Clone Rv105




::::::::::::::Rv105SP6.seq::::::::::::::







ATACTCAAGCTTGATTCCGCCGAAACCGACCGTGAGCACCCCGCCAGCCACCACGCTCGGGTCGGGCGCCGGGCCCGGGCCCGCCAGGCTGCTCCGCTCGGTGATGG




(SEQ ID NO. 14)







CACGCCACCGCGACACCACCCGGCTGCGCTACGTCTAACCATTCCAGGCGGAGCTACATCAGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCCAGGTCGAAGTCTA







TACCGATATGCGCATCCGCAGCCGCCACCCTGGAGAACAGAACGATGCCCTACTAATGCTTGTCTGGCGGGGCC







::::::::::::::Rv105T7.seq::::::::::::::







GGTACGCTTCGGTCGCAGTCTGCGAGTGATGCATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACCGGTA




(SEQ ID NO. 15)







GAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTCGGGGTGGTCGCGA







CGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTAGACGGTTCCTTTCCTAAGCAACACCGAAGTTTCAGGACCCGAATGCTCCGGGA







AACATGTCACGGTAGGTCGGTATTCCGGCTACCGGCTGA






Clone Rv106




::::::::::::::Rv106SP6.seq::::::::::::::







GGCGTCAACGGTGTCGGAACCCGCGTCAAGCAATTGGTAGGCCTGCAGTCTGTGAATCAGGCCGACGCTGTGGCCGCCGCGGC




(SEQ ID NO. 16)







::::::::::::::Rv106T7.seq::::::::::::::







GGCTNGCGTACCCGGTACCGGCCGCGGGCCTACCACGTGCCGGAACTGGAAGCGCAGTAAGCCCTCAACGCGCCACCGCTTTGGCCCGCGCGCCCGGCGTAGGCGC




(SEQ ID NO. 17)







ATCGGCGGTGGCCGTGGGGCGGCGCACTGCGACCTCACCAGCGGCTTTCGAGCTTTGTTCGATCAACCGGCCAGCATGGTCGANGATGCATTCGAGACCATATTCG







AAATTGGTTTCATCGGGGGCCCCGATCCGATGCCCCCTCCCAGTTGCGTGAGCAANCAGCGGAGTCNTCGCGGGATCGATGGCCACGGGGTGTTCAATGGCGGATG







GTCCGCTGCCCGCCGACTGGCTCTTGCGGGAGAACCGATCTAGCACCACCGATCCGCGCACGTNG






Clone Rv107




::::::::::::::Rv107T704.seq::::::::::::::







GTAATNTCGCGCACANCCANGACTTCTGGGGGGATCNGCTGACAGTGGNGGATCCCAAATTGCGGATGATCGGGCCGCCNACGTCGTTGTGTACCTCNTCNGTC




(SEQ IN NO. 18)







ACAACNAANCCGAANCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCNCGGGGTGAAGGCCTATGTCACCGGTCCGGCAACACT







CAATGCCGACCAGGCCGANGCCGGACACNANAGTATCNCTAACGTCACCGCGATCACGAGCATGGTGATCGNNCAATGTTNCTANTGATCTATCGCTCCGTAATTA







CCGCGGTTCTCGTCTTGATCATGGTCGCANCGAACTCCGGCGCAATCCGCGGATTCATCGNCTTGCTCGCCGATCACATATTTTCAGCCTTTCACATTGCAACNAA







CCTGCTCGTCTCATGGNGATGCGGCGACACGGACTACCGATATCATGCTCGCCGTTACACAATCNCGCCACGCCGCGAAGACNGGAAACGCTTCTACACAATNTTC







NCGGGACGCCACTNAACTTGGTTCNGGTTTGACATTGCCGCGCATGTNGCCCAGCTTTGCCGGCTCCCCTTA






Clone Rv108




::::::::::::::Rv108T704.seq::::::::::::::







TGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCGGATTGGCCCTGCNGCTGCAGCANACCATCGACGCC




(SEQ ID NO. 19)







ATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTTCNCCCTTTAACGG






Clone Rv109




::::::::::::::Rv109SP6.seq::::::::::::::







AACAGCTATGACCATGNTTACGCCAAGCTATTTAGGTAACACTATANAATACTCAAGCTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCA




(SEQ ID NO. 20)







NCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCCGCGGTCNGGTGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCC







ATATCCCGCGACNAACNACNCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCCGGGTGTGGGGTGTTTCGGC







GACCGGCAGCCAGGTGGTCCACACTGCCGACGGGCGCCGCGAGCCGTTCACCGACCAAGCCGCCGAACAAGTCCGCCCGATCGCATACTCCAACCGGTTGCGGTAC







TGCAGGTCAGCTGGCGTACCTCCTCNTCNCGCTGGCGAAGTCTTFGCTCANCACGTCGCAGAACGGCAAGGAACACGTTCA







::::::::::::::Rv109T7.seq::::::::::::::







GACCGNNCCATGTTTCCACAATGTGGTGCCAGTNCGGNGGCTACGTGCCATCNANACACTGGCGCAGGCTATCGCACCCGTTATCNGCTACGAACAAATNCGGTA




(SEQ ID NO. 21)







TGCGTTCTTTANCATGAGTCGGCGACCGNCGATCATGGTCGACACCCACGACNGAAATACGCAGATCGCCNTCNAGCNTGTGTGCCGCGGATTATCANGACTGACC







TCCTGGCTGACCGGNNTGTNTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGNTCGTGGTCGGCTCGGATAGCGAAGTCAGCTAATTCTCGTGGCAGCTCGAAAGGG







TCCTGCCGGTGCCGGTCTTTGCGCAAACCATGCNCATGTTACGGTCCCTCGGGTGCGGCCTGGCGGCGGC






Clone Rv10




::::::::::::::Rv10SP6D2.seq::::::::::::::







GGGATGGGCGGGCCCGCTAAACTCTTCGTGTTCCACTAACTCCGGGAGGGNCAATCTCGGGCCGTTATGGCTCACGTCGCGTCGCCCTCCGACCGCGAACATTCGG




(SEQ ID NO. 22)







AGTTGGCAGCAACCTGGTAGCACCCTGGCCGG







::::::::::::::Rv10T704.seq::::::::::::::







NCCGTCGTTGACAAGTAAATATGTCCGCAAAAGTCTCAGCGGCCGACTTTGCTCGCAGGTGGCGGTACCGCGCCACCGAGTCGATGCCGTGGTCGCGGAAGAATGC




(SEQ ID NO. 23)







CTCCCGAAATCGCACGGCCTTCCCNNTTTAAACGGA






Clone Rv110




::::::::::::::Rv110SP6.seq::::::::::::::







TTTAGGTGACACTATAGAATACTCAAGCTTTTGGTCTAGCCGGCCGAGCACGATACGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCG




(SEQ ID NO. 24)







GTGGTTTTGCTGATGAGTGCTGAACCGTANTCGAAGTGGGCGGCGTCAGACTCCACCCANCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCNATCC







GGACAAGTTGGGGTGCGTTTGGGGCAATGACAGGTGGCNGCGGTGCGTTCGGGTCCGCCGGCGGAAGTGCTGCGTTGGGATCNCCCGCTGGGCATTCGGCNTTTT







GCGGCGGCCGGTGGTNGGGGGGCAACAGGTNTCCCNGTGCGGGTGGCGCTCAACGGTCNACGGCGCAAGCCGCCGTTGTTGGTACCNGGGGCGCTGGCTCCGGATC







GCGTTGGCGGTCNCCGG







::::::::::::::Rv110T7.seq::::::::::::::







CTACACCATCGAATACGACGGCGTCGCCNACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTAC




(SEQ ID NO. 25)







TTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGANAACCTGCCGCTGC







TAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAANGTGATTGTTAACCTGGGCTACNGCGACCCGGCCTATGG







TTATTCNACCTCNCCGCCCAATGTTGCGACTCCGTTCGGGTTGTTCCCANAAGTCNNCCCGGTCGTCATCGCCGAANCTCTCNTCCCGGGACCCACAGGGAATCNG







CNATTTCNCCTACAAATCANCCACCTCCA






Clone Rv111




::::::::::::::Rv111T7.seq::::::::::::::







GCATGATCGGCCACCTTTCGGGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGT




(SEQ ID NO. 26)







GACGACTCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCACCAACGGCGCGAGCTCAACGACGTCAATCNCGTTGTCGCTTTCTACGGTCACCGACCCTGGT







GACCGTAGTTCNCCCG






Clone Rv112




::::::::::::::Rv112SP6.seq::::::::::::::







GACACTATAGAATACTCAAGCTTGCCAACCGCCAGCCTGCATCCGGCGGCGANCACTGCTCCGCCGACCAGTACGAACCAACCTGCGGTGCCCAGGCCATTGACGA




(SEQ ID NO. 27)







TGTGCTGGTCGGCGCCCGCGAGTCCGCGCACCATCAACGCCGCGGGCACCACCANGGCGGCCCCACCCTGCACGGCGACGATCATTCCGGCGCCGCTCACGGCGGG







CGGGGCTCGAACANGCACAGCATCAACGTNGTCACCCGGCCGTGACCGGCCCGCATCGTCACACCACCCAAGCCCATTGCCGTCCTCCTCAACNGGGCGACCCGGC







CCGCATCGTCACACGGNCTAAGGCCATTGCCGTCCTCCT







::::::::::::::Rv112T7.seq::::::::::::::







TCGGCGCCATCGGCACCTTCGAGGACCTGTATTTCGACGCCGTGGCCNACCTGAGGTTGGCGGTGGCNAAGTGTGCACCCGGTTGATTCGCTCGGCCTTGCCGGA




(SEQ ID NO. 28)







TGCCACCCNGCGCCTGGTGGTCGATCCGCNAANAGACAANTTGTGGTGGANGCTTCTGCTGCCTGCGACACCCACNCGTGGTGGCACCGGGCAGCTTTAGCTGGC







ATGTCCGACCGCGCTGGCCGACNACTCCAGACNTTCCACNAANGGTCGCONNCCCAATGTNCCGNANTGTCTCCGGNTCCCTTTACCNCCCAATGGGCNGNTTCC







ACNGGTTACGGGCCCCNTNCCGGCGGGTCTNCCTCCCAANCTACCAAATACGCCCGACNTTCCGGA






Clone Rv113




::::::::::::::Rv113SP6.seq::::::::::::::







ATACTCAAGCTTTTATGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCG




(SEQ ID NO. 29)







GGTGCAGGTCTCGGGCAGCTCGGCCGCGAACAGCCCGGCTTGAACCCTGAAAACCNGCTTTCCATATCCCGCGACGAAAGAACGCCAGTTCCGCTACTTAACCCC







TCCGCGAACCGTCCATGGACAACAGCGCGTTCTCCACCAACCGGGCCCGGGTGT







::::::::::::::Rv113T7.seq::::::::::::::







TCGGCTCAGGCCGCGCTGCTGGTAGAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCG




(SEQ ID NO. 30)







CACCCGTTATCGGCTACGAAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCA







AGCATGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGA







GGTCAGCGAATTCTCGTGGCAGCTCGAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACAATAGCGCAGGTTACGGTCGCGCGGGGTGCGGCCTGGCGGCGGCC






Clone Rv114




::::::::::::::Rv114SP6.seq::::::::::::::







CAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTCGCGTCTACGCCGGCCCGGAGCATCCGCACAGCGCTCAGCAGCCGGTTCCGTACGANCTCAAGCAGGTG




(SEQ ID NO. 31)







GCGCAATGACCGAAACCACCCCAGCCCCGCAAACCCCGGCGGCCCCGGCCGGGCCCGCACAATCGTTCGTGTTGGAGCGGCCCATCCANACCGTTGGGCGCCGTAA







GGANGCCGTGGTACGAATGCGGCTGGTGCCCGGCACCGGCAAGTTCGACCTCAACGGCCGCAGCTTGGANGACTACTTCCCAAACAAGGTGCACCAGCAGTTGATC







AAGGCACCCCTGGTCACCGTGGATCGGGTGGAAAGTTTCGACATCTTTGCCCACCTGGGCGGCGGCGGCCGTCCGGTCAGGCCGGGCCTGCCCTGGGTATCGCCCG







GGCATTGATTCTGGTATCCCCNGAAGAACCG







::::::::::::::Rv114T7.seq::::::::::::::







CGGTTGGCCACCGCTTCTGCGGTGCCGCCGCCGTCGACAATGACCGTGTCGTCCTTGCTGACCACCACGCGTCGGGCCCGAGCCCAGCACCTCCAAGCCCACCTCGC




(SEQ ID NO. 32)







GCAGCACCATGCCGGCGTCGGGGTTGACCACCTGGCCACCCGTCACCACCGCCAGGTCCTCAAGGAAACGCTTACGGCGGTCACCGAAGTACGGCCCCTTGACCG







CGACCGCTTTCAACGTCTTGCGAATCGCGTTGACGACCAGCGTCGCCAACG TTCGCCCTCCACGTCTTCAGCCACGATCAGTAGTGGCTTACCGTTCCTGCAAC







CTTTTCCAGCAATGGCAACAGATCGGGAAGCGANCTGATCTTGTCTTGGTGCN






Clone Rv115




::::::::::::::Rv115SP6.seq::::::::::::::







CCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTTTGGCTGGGTCGCCTTCGAATTCNGCGTGCACCGCTATGGGTTGCANCAGCGGCTGGCGCCGCACACC




(SEQ ID NO. 33)







CCACTGGCCCGGGTGTTTTCGCCCCGAACCCGATCATGGTGAGCGAAAAGGANATTCNCCTGTTCGATGCTGGGATTCGCCACGCCAAGGCATCTANCGATTACT







CTCCNCGGGGTGGGAAAAGTGCCCAATCCCCTCCCTCCAACTTTCCNAACAATCATTCCGGTTCCNCCNTCCGGTTGGNGGTAACCNNCCAATAAAACCCCTGCC







CG







::::::::::::::Rv115T7.seq::::::::::::::







GCCCGCNCATGGCCAATCCCCGAAGACATCATTGGCCAGTGGCCGGGCGCTAACAGGTTCCAGCCCCCCACCANTGCCGCTCGAACATGCGGTGCAACCCATTCGC




(SEQ ID NO. 34)







AGGCCGGCAGGGAAAGCACCGCGGAAGCCGCAAAGGGCTGCAGTTCCGCGCCCAATAATGTCGTCCGCAACCAGATGCGCTCNAAAACCNCNCCGGCAGTCAGCGC







ACCCGACGCGANGTCGAAAGACGTCNTCAGCGCGCCCACATGGGGTGCCAATCGGCACGGCAGGTATGCCGCGCGCAACCCGAGCGCGTGGTGCATGCCCACGGTC







CGCANGANGCGCANCACCCGCCAATGCCGAANCCCACGAAACATCGGGCGCATCCACCTTCAACC






Clone Rv116




::::::::::::::Rv116SP6.seq::::::::::::::







ATACTCAAGCTTGCCCAGCCGTCGATGACAAGAAATATGTCCGCAAAAGACTCAGCGGCCGACTTTGCTCGCAGCTGGCGGTACCGCGCCACCGAGTCGATGCCGT




(SEQ ID NO. 35)







GGTCGCGGAAGAATGCCTCCCGAATTCGCACGGCCAATTCCATTCCGGGAAGCATCCGCAATGCCAGCTGCGGTTGCCCCCTGCCGGCCACGGCACCCACTTGCGG







CATTGCGTCCACCTGGGCCAGCGCCCCGCCGCCAAATTCCAAACAATAAAAATTGCACCCGGC







::::::::::::::Rv116T7.seq::::::::::::::







CCACCCGTGTATTTTGGGATGGGCAAAAAGGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAAC




(SEQ ID NO. 36)







GTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGG







TAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCTACACGGCGATATGTTCGCCTCCCTGCC







CCGT






Clone Rv117




::::::::::::::Rv117SP602.seq::::::::::::::







CTGCCCATGTTTGGGGACGCCCGACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACC




(SEQ ID NO. 37)







GGCAATACCTACCGCAGCCNGACCCCTNTCNCAANAGGATNTTGTTCGCCGGACCCCNCTC







::::::::::::::Rv117T704.seq::::::::::::::







CCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGA




(SEQ ID NO. 38)







CGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATC







GTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGCGACCGCCTTT






Clone Rv118




::::::::::::::Rv118SP6.seq::::::::::::::







ATACTCAAGCTTTGTCACACCAAGTGTTTCGACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCA




(SEQ ID NO. 39)







GCTCGCTTGCGGCGCTGCAGCAGCCATTCGGGGAAATACCTGCCCTGGCGCAGCTGGGGGATCCCAACTTCAATGGTTGCGGCACGGGTGCTAAATTCACGGTGGC







GGTAGCCGTTGCCCTAATTGGACCGCTCATCGCTGCTTTCGCGGTACCCCGCCCCGCACAGGGCTTCGGCTTCAGCCCCCATCAGGGCGGCAATAAACTTCAAGAG







CACC







::::::::::::::Rv118T7.seq::::::::::::::







GAGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGCCCACCCTCATTGGCGATGGCGCCGACGAT




(SEQ ID NO. 40)







GGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTTGCGGACGGTCCCGACGCTGGTCGCGGTTG







CGCCCGCGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGGCGGCATGCACGGCCAGTGCCGCGGCGATGTCAGCCTCGGGACATCATGCTCGCGTT







CATACTCCTCGACCAGTCGGCGGAACAGCTCGATTCCCGGACCGCCCAGCGCATTGGTGATGGAATCGGCGAACTTGGCCACCCGCTGGGTGTTGACATCCTCGAC







GGTGGGCAATTGGCCTCGGTAAGCTTTGCCGCGTAGCTTTTCATC






Clone Rv119




::::::::::::::Rv119SP6.seq::::::::::::::







ATACTCAAGCTTCACTGACAAGGGACGAATTCGTCGGCCGCCTGTTCGACTGGGTGGTGGCCGAGCTGGTCGCCACCACTCAGGCCGCGGTCACGGCGGTACCGGC




(SEQ ID NO. 41)







GCGGGAGCAAACTCGCGCGGGCATGGCCAACTTCTTGCGGACCATCACCGCAGACGCCCGCTTCGGACCCCTGCTGTCCACCACACAGTTGGCCAACGCATTAATC







ACCCGCAAGCTTGCGGAATCCACCGCCCTGTTCGC







::::::::::::::Rv119T7.seq::::::::::::::







TCCATCACCCGATGTGGCNGGAGCACTGCCATGTCGATCTCAACTACCACCTCCGGCCGTGGCGGTTGCGCGCCCCGGGGGGTCCGCGCGAACTCGACGAGGCGGT




(SEQ ID NO. 42)







CGGAGAAATCGCCANCACCCCGCTGAACCGCGACCACCCGCTGTGGGAGATGTACTTCGTTGAGGGGCTTGCCAACCACCGGATCGCGGTGGTTGCCAAAATTCAC







CATGCGTTGGCTGACGGTGTTGCCTCGGAAACATGATGGCACGGGGGATGGATCTGCCGCCGGGACCGGAGGTCGGCCGCTATGTGCCTGACCCCGCTCCTACCA







AGCGGCA






Clone Rv11




::::::::::::::Rv11SP6.seq::::::::::::::







AGCTTTGCAGTTGCTGAGTAATGTCGGCCAACGTCACCACAACCGCGATGAATTCAATCATGCCGCCCAGGGCGGCCAACCAATGGTGGCCGCGAGCGGCAGCTC




(SEQ ID NO. 43)







GATCGCAGCGCGGAGGTTGCCGGCCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAAGGCAAGACCTCCATCTGCCGTCGGAAGA







AGTATCGAG







::::::::::::::Rv11T7.seq::::::::::::::







AGCTTCAGAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCACGCAGGGCCGC




(SEQ ID NO. 44)







GGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCGTCGCGTTCACTAATCGCGGTG







CTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGCGACCAGCTGCTCCACCACGGACCGAGCGATGCCCGTC






Clone Rv120




::::::::::::::Rv120SP6.seq::::::::::::::







ATACTCAAGCTTCAGTTCCTCCACGACGCGTTCCCAAATGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGG




(SEQ ID NO. 45)







GCGGATTGGCCCTGCCGCTGCACCAAACCATCAACGCCTTCAAATTGCCGGCAATCTCGTTCAGCCAATCCAT







::::::::::::::Rv120T7.seq::::::::::::::







GCTCTACGCCGCCTACGGGTCGAACATGCATCCCGAGCAGATGCTCGAGCGCGCACCCCACTCGCCGATGGCCCGGAACCGGCTGGTTACCGGGTGGCGGCTGACG




(SEQ ID NO. 46)







TTCGGCGGCGAGGACATCNGCTGGGAAGGGGCGCTTGCCACCGTCGTCNAAGACCCAAATTCGAAGGTGTTCGTCGTGCTCTACGACATGACCCCGGCGGACGAGA







AGAACTTGACCGGTGGGAAGGCTCCGAGTTCGGTATCCACCAGAAGATCCGATGCCGCGTGGAGCGCATTTCCTCGGACACCACAACGGGATCCCGTCCTCG






Clone Rv121




::::::::::::::Rv121SP6.seq::::::::::::::







ATACTCAAGCTTGCCAAAGAGACCTCGTCCACCAAGCAGGACGCGACCGTCGAGGTGGCGATCCGGCTTGGCGTCGACCCGCGTAAGGCAAACCAGATGGTTCGCG




(SEQ ID NO. 47)







GCACGGTCAACCTGCCCACACCGGCACTGGTTAAGAACTGCCCGCGTCGCGGTTTTCGCGGTTGGTGAAAAGGCCAATGCCTGCGTTTGCCGTGGGGGCGGATGTT







GTCGGGAGTGACAATCTGATCAAAAGGATTCAGGGCGGTTGGCTGGAATTCAATGCCGCAATCGCGACACCGG







::::::::::::::Rv121T7.seq::::::::::::::







CCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGAAAG




(SEQ ID NO. 48)







TCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTTGGCGTTG







ACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCGTCCACCGC







GACGTGCAGCGGGGCGCACCAGCGACTTCTCCGGGGTTGACCGGGTNATCT






Clone Rv122




::::::::::::::Rv122SP602.seq::::::::::::::







GCAGCATGACGGCGGTAGCGAACACCGCCGGATGCAGCGCAAGTAGCGTCGATGTGCTCACGGAATCGCCCCGGCACCGCGATCTCGANGATCACCAGTGCCACCC




(SEQ ID NO. 49)







CCTGCAGCGCNACACCGACGATTCCGTACACCGCCACGCCGATCAGGCCCTGGGCCATCTGATTGGAGCTGGCGTANATGGCGGCGATGGTGACGATGGCCAGCGC







CACATACATTGTGGCGGCCAGAACCACGGCGTTGGGGCGGCGGTCGATGAACACTAGGCGACGCAGATCGCCCGGGGTCAACAGGTTGACCATCAGAAAGCCTGCG







ACTAGCACGGCGGCGCCACTAGGAGGTACAAGAANGTGGCCACCACCCCATGCAGGATCGGGGTAAGGCTGATGGTCCCGAAATCGACTCCGGCCTAATACATGAC







TCTCTCCTTTGCGTCATCGCCTTACTTGTGCGCGGAA






Clone Rv







::::::::::::::Rv123SP602.seq::::::::::::::







GGGACACACCTCGATGCTGCCGCNATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACGCATCCCGTT




(SEQ ID NO. 50)







GACCGGCCGGANCNCTCTCTA







::::::::::::::Rv123T704.seq::::::::::::::







TGGGCGCCTCTTTCGGCCTTCCCNNTTTAAACGNAGCANGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGG




(SEQ ID NO. 51)







GATCCGACTACAATCTGCTGCTGATTTCCCGGTTGAAAGAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGAC







GGCTGCCGGCATGGTGTTCGCCGTTACCATGTCGTTGTTTGTGTTCAGGATTTGCGAATTATTGGTCAGATCGGTACCACCATCGCCTTCCC






Clone Rv124




::::::::::::::Rv124SP602.seq::::::::::::::







CCGATCGGCGCCGCANCTGGTTGGTGTTNCGGATGAATCGCAGCGAAAATGTAGCTGCGGTGGCGTGTCGTGACTCGTNGGCGTCGACGCTCGTGGCAGCCACCG




(SEQ ID NO. 52)







ANCGGTTGGTCCAGGATCTGGATGGGCAAAGTTGTGCGGCCCGGCCGGTGACGGCCGATGAGCTGACCGAGGTCGACAGCGCCGTGTTGGCTGACTTGGAACCGAC







ATGGAGTCGCCCCGGTTGGCGTCACCTCAAGCATTTCAATGGTTATGCGACCAGTTTTTGGGTTACGCCGTCAGACATCACGTCGGAGCTTGGATGAGCTGTGTC







TGCCAGATAGCCCCGAATCGGGACGACCGTGGTCACGGTGCGTCTGACCACTCGGGTCGGGTCGCCCGCGCTATCGGCATGGGTGCGTNATCACAGCGACACGCGC







CTGCCCAAGGANGTNCGGNCGGACC







::::::::::::::Rv124T7D4.seq::::::::::::::







CGGGTTGCGGATCCACGCGTGCGGGTTGTCAGCAGCTACGGCACTGAACCGCGCCCACAGCTCGCCGATCCGCTTTCGGTGGTTCTCGATCGACTCGCCGTAGGCG




(SEQ ID NO. 53)







ATGCGCAGCGCCTGCTCGAATATCGGGTACACGTAGGCCGGCTTCCCNCTTTA






Clone Rv126




::::::::::::::Rv126SP6.seq::::::::::::::







CTTGATTTTGATCATCATGACGATCATCACCCTAATTTTGCTACCCGCACTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCGGTCGGGCTTTCCGTA




(SEQ ID NO. 54)







TTGGTCTGGCAGGACATTCTGGGTATCGATTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTGCTGATTT







CCCGGTTGAAAAAGGAGATTGGGGCGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGCAGTGGTGACGGCTGCCGCATGGTGT







::::::::::::::Rv126T7.seq::::::::::::::







GGGGATCCCTAGATCGACCTGCAGGCATGCAAGCTTGGCGTGTCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGCGGGACCCACCTCGATGCTGCCGC




(SEQ ID NO. 55)







CATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATC







GTCGATGACGGCATCGCCACCGGAGCNACTGTCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAGACG







ACATCGTGGCGAGATTCGNGGGGTACGCCGATGAGGTGGTGTGTTTGGCGACGCCGGCGTNGTTCTTCGCCGNCGGGCANGGTTACCGCAACTTCACCCAGACCTC







CGACGACGAGGTGGTGGCGTCTCTCCTGGATCGTGCTC






Clone Rvl27




::::::::::::::Rv127SP6.seq::::::::::::::







AAGGCTGCAGGTCGAAGCGGNTGGTTACGACTCCCTGTGTGTGATGGACCAGTTCTACTATCTGCGTCTACACGGCCTTGGTGCGCTGGCCACGGCGACCGAGCG




(SEQ ID NO. 56)







GCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCCGACCCTGCTGGCAAAGATNATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCT







CGGCATTGGAGCCGGCGGGTTTGAACTGGAACACCGCCAGCTCGGCTTCGAGTCCGGCACTTCCAGTGACCGGTTCAACCGGCTCGA







::::::::::::::Rv127T.seq::::::::::::::







CTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCN




(SEQ ID NO. 57)







GCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTACAGCCACTGCGATCGGTGCCGATCGTGG







GGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCGccGNcCAATGTTGCGAC







TCCGTTCGGGTTGTTCCAGAAGTCAGCCCGCTCGTCATCGCGGACGCTCTCGTCN






Clone Rv128




::::::::::::::Rv128SP6.seq::::::::::::::







CGGTCATAGCCCTCGGGTCCGGCCAGCACTCCGCAGCCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCA




(SEQ ID NO. 58)







CGTAGACGGTTCCTTTCCTAAGCAACACCGAAGTTTCACGACCCGAATGCTCCGGGAAACATGTCACGGTAGGTCGGTATTCCGGCTACCGGCTGAGCATTGAGCA







CGCCGGCCAGCACCGCACGAGCCAGGCAATCAGCCGCCGCCGCACCGATCGCGGTGACCAGCTGAGTCTCCGGAGACAATGCGGCCGGCACGCCGGNCTCCGGCGG







CACCGCTACNGCGCCCGTGG







::::::::::::::Rv128T7.seq::::::::::::::







GTGATGGCACGCCACCGCGACACCACCCGGCTGCGCTACNTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCG




(SEQ ID NO. 59)







AGGTCGATACCGATTTGCGCATCCGCANCCGCNCCCTGGACGACAGAACCGTGCCCTACGAGTGCTTGTCGGGCGGGGCCAAAGAACAGCTTGGCATCCTGGCGCG







ATTGGCCGGCGCGGCGCTGGTCGCCAAGGACGACGCCGTTCCGGTGCTGATCGACGACGCGCTGGGGTTCACCGATCCGGAGCCACTATCAAGATGGGGGAGGTCT







CTGACACCATCGGCCCCGACGGACATGTGATCGTGCCGACGTGCAGTCCCACCCCG






Clone Rv129




::::::::::::::Rv129SP6.seq::::::::::::::







GCGAAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTT




(SEQ ID NO. 60)







GGCGTTGACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTNNGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCGT







CCACCGCGACCGTGCAGCGGGCGCACCAGCGACTTCTCCGGGGTTGACCGGGTGATCTCGGCGAAATCAGATACGCTGGCGCCGCGACGACCAGGCGTCGTGGGCT







TGTNCTTGCGAATTGNCATGTCTAATCANGTCTTTCTCTCACGCTCTCGTCGCCGGGCTAGGCCGCATTGCCCTGCTCCTCCTCATCGCTTCGCTCTGCATCGTCC







CCGGGCTAAGCCGTGCCCCGAAA







::::::::::::::Rv129T7.seq::::::::::::::







GATGGTTCGCGGCACGGTCAACCTGCCACACGGCACTGTGTAAGACTGCCCAGCGTCGCGGTATTCGCGGTTGGTGAAAGGCCGATGCTGCCGTTGCCGCGGGGGCG




(SEQ ID NO. 61)







GATGTTGTCGGGAGTGACGATCTGATCGAGAGGATTCAGGGCGGCTGGCTGGAATTCGATGCCGCGATCGCGAACACCGGATCAGAATGGCCAAAGTCGGTCGCAT







CGCTCGGGTGCTGGGTCCGCGCGGCCTGATGCCCAACCCGAAACCGGCACCGTCACCGCCGACTCCCCATGGCGTCCCGGATATCAAGGGCCGGCAAATCAACTT







CCCGGTTGATCAGCAAGGCAACCTGCCTCCNCCTCCGG






Clone Rv130




::::::::::::::Rv130SP6.seq::::::::::::::







ATACTCAAGCTTCGTCATAAGACCATGGTGCGCTTTCTTTCACCCGTCCAGAGTCGGGGGCATCGGCACCGGCTCGCATCGCATCATCCTCCCACGACGGGCCCT




(SEQ ID NO. 62)







CATCAGCTTGGGCCATTTCAATGTACTTGATACCCCGCGCTGCGGGTAGGCCACTGCGACAATTCAAACACGGTGTCACACGGTGAATAGTGTCGAGATGGGCTCT







GATCAACCGTCGCAAACCCGGTTTCGCATCAATAGCGGAATCCCACCGGGTTGCATGGAGGCTGCTGACCTTGGAAAACAAAATTTTTTCATTACAACAAAACAAC







CGCCNCGGAAACTTTGCA







::::::::::::::Rv130T7.seq::::::::::::::







CGAATTCGGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCGCCGCACACCCCACTGGCCCGGGTGTTTTCGCCCCGAACCCGGATCATGGTGAGCGAAAAGGAG




(SEQ ID NO. 63)







ATTCGCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCGCAGTCCCGCTCCGTCGACGTCTCCGACG







ATCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCTGCAAGGTGATTCTGTCCCGTTGTGTCGAAGTGCCTTTCGCGA







TCGACTTTCCGTTGACCTACCGGCTGGGGCGTCGGCACAACACCCCGGTGAGGTCGTTTTTGTTGCAGTTGGGCGGAATCCGTGCTCTGGGTTACAGCCCCGAACT







CGTCACGGCGGTGCGCGCCGACGGAGTTGTTATCACCGATCCGTTGGCCGTACCGCGCCTTGGGC






Clone Rv132




::::::::::::::Rv132SP6.seq::::::::::::::







TCAGACTCCACCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTGGGGCAATGACAGGTGGCGGCGGTG




(SEQ ID NO. 64)







CGTTCGGGTCGGCCGGCGGAGGTGCTGCGTTGGGATCGCCCGGCTGGGCATTCNGCGTGTTGGCGGCGGCCGGTGGTGGGGGGCAACAGGTGTCGCCGGTGCGGG







TGGCGCTGCAGCCGTCGACGGCGGCGAAGCGGCCGTTGTGGGTACCGGGGGCGCTGGCTCCGGATCGGCGTTGGCGGTCGCGGGCACCGCAACGGTCACCAAGCTG







GCGCTGGCCATCGCCGCGATAGCCAGTGCCGCCAATCGTCCCTTGCGACGTGTCAAGTNGGGGTCCACCTGATGCATGGCCAAAGAACCTACCGTGTTAACGGCGC







AACNCAAGGACCGCGCCGGTCGCN







::::::::::::::Rv132T7.seq::::::::::::::







TTTCCGCGGTACCCGCTCAACTTTGTGTCNACCCTCAACGCCATTGCCGGCACCTACTACGTNCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAG




(SEQ ID NO. 65)







CGGGTCCGCTGAACAATTCGGTCCGTCCCACGAAAGAACCAGTTTTNCNTCTTTCNCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGG







GGAACCCACTGGCGAACCTGTGTTTCAACCAACACTTAGAGTGTAATTGTAAACCTGGGCTAGGGGAAACCGGCTCTAGTTTTTCCACCNTCTCCGCCCCNTGTTT







CGAATACTCCGTTCGGGTTGTCCCCAAA






Clone Rv134




::::::::::::::Rv134SP6.seq::::::::::::::







GCTTCCGGCTCGTATGTTGTGTGGAATTGTGACCCGATACCAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTAGTTAGGTGACACTATACAATA




(SEQ ID NO. 66)







CTCAAGCTTGCCGGCTGGTGGGCCGACCACTTCGATGGCACGACCCGTGAACTGCTGCCCGGCCAATTCTTCTTGGTCGCCCGGACCGATGGACCGGGGCTGGGAT







TCCAGAAGGTGCCCGATCCCCTGGGAAAAACCGCGTGCACCTCTACTTCACGACCAACGAC







::::::::::::::Rv134T7.seq::::::::::::::







CCGATCGACTGATGCGCCGACAACCACGCCCCAACAACTGGAATGAACCGTCGTGACCATCATCAGCACGGGGTTGTAGGCGACTTGCGACATGTTCAACCCGCCG




(SEQ ID NO. 67)







TACTCGGACGGAATCTTCAAACCGAAACAGCCCAGCTCGGCCAGGCCTTTCACGTACTCGTCGGGGATCTGGGCACCACGCTCGAGGACGCTGCCGTCCACGGTGT







CTAGGAATTCCCGCAGTTTGACCAGAAACGCCTCGGTTCGGGCCTCCTCGGCGTCCGACGGCTTGGGAAATGGGTGTATGAGCCCTACGGGAAACCGGCCCACAAA







GAGTTCTTTGGCGAAGGACGGTTTATCCCAACCACTTTCGCGAGATTCCTCGGCAAGGGCCCGCGCTTGCTCCTCGGTGACCTGAGTTTGCTGTGCCATCGCCGCC







TCCTCCCTGA






Clone Rv135




::::::::::::::Rv135SP6.seq::::::::::::::







TGCATCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT




(SEQ ID NO. 68)







ACTCAAGCTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGG







TGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTG







TCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCCGGGTGTGGGGTGTTTCGGCGACCGGCAGCCAGGTGGTCCACACTGCCGACGGGCGCCGCGAGCCGTTCA







CCGACCAGGCCGCCGAGCAAGTCCGCCCGATCGCATACTCC







::::::::::::::Rv135T7.seq::::::::::::::







GGGGGCGCTGCrGGTATAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTT




(SEQ ID NO. 69)







ATCGGCTACGAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCATGTGT







GCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGAGGTCAGCGA







ATTCTCGTGGCAGCTCGAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACGATGGCGCAGGTTACGGTCGCGCGGGGTGCGGCCTGGCGGCGGCCAGAGCACGAG







TTCACCGATGCGCAGCTAGTGGCGACAGCGTCAGCCAAC






Clone Rv136




::::::::::::::Rv136SP.seq::::::::::::::







TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT




(SEQ ID NO. 70)







ACTCAAGCTTCCGTACAGGTCGCCTCCAACACGGCGGGGAAGCGACACCAGCCTACCGAGCTTGGAGTCCAGGACGCCAGCGGCGGCGTCGGTCTGCGTCGTGGTG







CCGCCGGGGTGGCGTTGGCTGGCAACGATCTCCACCCAGCCGGTCGGGTTACCCACGATCTCGGCATAGACGoGGGCCGAGGCCGGTGCGATACCGTATTGCGTCA







ATTGGGACGCGGTTGTGCATTCGGCTAGCTCGGTTGCCACACCCGTCAGGGGTTCGACGTTGGCGGGTTCGGCGGGCCCCAGCACCGCTGTCACCATGCCCGCCAA







GCCGACCTGCGGCGCCACCAACT







::::::::::::::Rv136T7.seq::::::::::::::







CGGCATGACCACCGACAGGCCCGACTGGTCGTACCACTCGAACGCCGGGGTGTTGATGTCCCAGCCGCTGAAGTCGTCCTGCGCGCGCAGGCCGTCGAGCAGGTAC




(SEQ ID NO. 71)







AGGGCGGGCGAGTTGGCACCACCACTTTGGAATTGGACCTTATGTCACGGCICCATCGACGGCGACGGCACCTGCAGGTACTCCACCGGCAAGCCCGGCGGGGAAA







ACGAACCCTGTCAACAAGCTGCATTCTTGCTTCCCTCATCCTCATCTCAACGCATCCATGCATGTTTGGGCGCATCCTGAATTANGTCAGACTGCAGGCGCTGGGC







CGGCAGTGCTCGTGTATCAACCACAACTTGGGGCGT






Clone Rv137




::::::::::::::Rv137SP6.seq::::::::::::::







TTCCAACCCTAATTGGCTTTCGGCCCCATCCGTGAGGACGGGGTGCGGGTGCTCAACAACAACGTCGTCCGCGGGACACACCTCTATGCTGCCGCCATGGACGCGG




(SEQ ID NO. 72)







TCCAACGCAAGCAGCTGATCGAGCTACAACCCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGCATCGCCGTGATCGTCGATGACGG







CATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCACGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAAACGACATCGTGGCG







AGATTCGCCGGGTACGCCGATGAGGTGGTGTGTCTGGCGACGCCGGCGTTGTTCTTCGCCCTCGGGCAGGGTTACCGCAACTTCAC







::::::::::::::Rv13T7.seq::::::::::::::







CAGGCATGCCAGCTTTCCGCCGATACCCGCCATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGcGQATGATCGGGCCG




(SEQ ID NO. 73)







CCTACGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAA







GGCCTATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGCCGGAGACAAAAGTATCGCTAAGGTCACCGCCGATCACNAGCATGGTGATCGCAGCAAT







GTTGCTAGTGATCTATCGCTCCGTAATTACCGCGGTTCTCGTCTTGATCATGGTCGGCATCGACTCGGCCAATCCGCGGATTCATCGCCrTGCTCGCCGAACACAA







CATTTTCACCTTTCACATTTGCACCAACCTGCTCTTCTCAT






Clone Rvl38




::::::::::::::Rv138SP6.seq::::::::::::::







CACTACTCAAGCTCTCTCNTCATTACCACCCCTGTAATTTGGGATGGGCAAAAAGGCGAAGCACCGCTTGGCCACNAACGCCGGGAGGGACAATCTCGGGCGGCTA




(SEQ ID NO. 74)







TGGCTTCTCCCGGGAAGGCCCCAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATTGGCACCAACCTGNTACCACCCTGGCCGG







GCGATGATCTGCAGCGTCGCCGCGGGTAGTCCCCGCCCGGGCGGCTACAGTCTGAAACCCCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCT







ACACGGCGGATATGTTCTCCTCGCTGCGCCGCTGGACCGGTGGGTCTATCCCCTGAAACCGACATCCCN







::::::::::::::Rv138T7.seq::::::::::::::







CAGGCATGCAAGCTTTCGTCAGTTCATTGCGCCAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGA




(SEQ ID NO. 75)







CGGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCrACTCCCAGGGTGCGGCCGTGATCGACATC







GTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGACGATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGCCGCG







CTGGCGGGCTGATGAGCGCCCTGACCCCTCAATTCGGGTCCAAGAACATCAACCTCTGCAACAACGGCGACCCATTTGTTCGGACGGCAACCGGTGGCAACGCACC







TAAGCTACCTGCCCGGGATGA






Clone Pv139




::::::::::::::Rv139SP6.seq::::::::::::::







GTTTATGCACTGGTTAGGTGTTTCCATGAGTTTCATTCTGAACATCCTTTAATCATTGCTTTGCGTTTTTTTATTAAATCTTGCAATTTACTGCAAAGCAACAACA




(SEQ ID NO. 76)







AAATCGCAAAGTCATCAAAAAACCGCAAAGTTGTTTAAAATAAGAGCAACACGTACACAAGGAGATAAGAAGAGCACATACCTCAGTCACTTATTATCACTAGCGC







CCGCCGCAGCCGTGTAACCGAGCATAGCGAGCGAACTGGCGAGGAAGCAAAGAAGAACTGTTCTGTCAGATAGCTCTTACGCTCAGCGCAAGAAGAAATATCCACC







GTGGGAACTCCAGGTAGAGGTAC






Clone Rv13




::::::::::::::Rv13SP6.seq::::::::::::::







ATACTCAAGCTTGGGTGTAGCCGATCACCGGAAGTCNCATGATCAGCCACGTTCCGCGCCGCCCGGCATACGGTGGTGTACCGATCTCCGCGTCATACACCCGCGG




(SEQ ID NO. 77)







GTAATCGCCGACGGTGCCGGTTCGGGAGCCAA







::::::::::::::Rv13T7.seq::::::::::::::







AGCTTTATCTGAAAGCGAACAGCTCGCGGCGGCCCACGACGTGCTGCGTCGGATTGCCGGGCGGCGAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCT




(SEQ ID NO. 78)







GGCCCGCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAG







CCCGGCAGTTGCCAAACCCATCGTGATCAGGCTCGGCTCGCGAGTTCGGCGAAGAAATGGTTCGCCTGATCACCTACCATCGGCCA






Clone Rv140




::::::::::::::Rv140SP6.seq::::::::::::::







TCAACACGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCTCCAGGCTNCTCCGCTCGGTGATGGCACGCCACCGCGACACCACCCGGCTGCGCTAC




(SEQ ID NO. 79)







GTCGAGCCATACCGGGCGGAGCTACATCGGCCCGGCCGCCCAGTGTTCGGGCCCTCTCGCCCAGGTCGAGGTCGACACCGATTTGCGCATCCGCAGCCGCACCCTG







CGACGACAGAACCGCGGCCCTACCCACTGCTTGTCGGGCGGGGGCCAAAGAACCAGCTTGNCATCCTGCCACAATTGGCCGGCGCCG







::::::::::::::Rv140T7.seq::::::::::::::







CAGGCATGCAAGCTTCACGTCCGTACGGCTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCAC




(SEQ ID NO. 80)







ACCTTCAGTTGCTCACCGGAATCCAACCGGTAGAAGGTCGGCCAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCA







GCACTCCGCAGGCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTAGACGGTTCCTTTCCTAAGCAA







CAC






Clone Rv141




::::::::::::::Rv141SP6.seq::::::::::::::







AATATTCAAGCTTTCGGCGGAAACGGACNCCTTGCGAACATTGATAACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAA




(SEQ ID NO. 81)







ATTCCAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCNTTATCAGCCNAAATAACTGCTCTCGGGTACCACCCAAACAGCGCAATA







TGGCGAAAAACGGTCGCCGTTGCACAACATTAAATGTCTCGGTATTGTTGATTAAAAAGATACCCACCACCAGGGCAATCCAACTGAGAGCGGTTAAATTGACCGT







AAAAACCTCCCGTCATCTGTTT







::::::::::::::Rv141T7.seq::::::::::::::







CAGGCATGCAAGCTTGCTGCATCTTCCTGTGACTGCTCCCGAAACCTGGGGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGATACCCGCGGT




(SEQ ID NO. 82)







CGAACCAGCCACGTGTCCATCATCAGGGGTCAACCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGAG







CAAAACAGCTGGTCGGCCGTTAGGAACTGAATTGAAACTCAACCGATTTGGTGCGGCCGTAAGTGTCCTGTCTGCGGGTGCGCTGGTGTTGTCCGCGTGTGGTAAC







GACGACAATGTGACCGGGGGAGGTGCAACCACTGGCCAGGCGTCCGCGAAAGTCCATTGCNGGGGGAAGACAC






Clone Rv142




::::::::::::::Rv142IS1081.seq::::::::::::::







GAAAGTGCCCCAAGGTGTTGGTGAAACTCGCTGGACGGTCCCCAGGATGTTGGCAGCACATTCACCGGACATGACCGGAGCAAGACCGGACATCCTCCCATACCGT




(SEQ ID NO. 83)







CGTCGCCGTGTACATCCGTAGCCCGTCCTGGCAGGTGCTGGGTTGAACAAAATCAGCCCAACACCTGCCACGACGAAGAAGCGGGTTGCGCTGGCATGTCTTGTCG







GCTCGGCGATCGAATTCTACGAATTCCTTATCTACGGGACCGCTGCGGCGCTGGTGTTTCCCACCGTGTTCTTCCCACACCTGGATCCCACGGTGGCCGCCGTGGC







CTCCAAGGGGACATTTGCTGTGGCGTTCCTATCCCGGCCGTTCGGCGCGGCCGTCTTTGGATACTTTGGAGACCGCCTCGGCCGCCAGAAGACCCTGGTCGCCACA







CTGTTGATCATGGCCCTGGCAACCGTGACTGTTGGGCTGGTTCCACGACAGTGGCCATCGCGC







::::::::::::::Rv142SP6.seq::::::::::::::







ATATTCAAGCTTTGTCACACCAAGTGTTCCGACCAANCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCA




(SEQ ID NO. 84)







TCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGAAATCACGGTGGC







GGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGTAGCCCNCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCCAAGGCGGCGATGAACGTCGAGA







GCAGCCCGCGCAGCAMTCCGGGCTCGCCTGTGCGAGTTGGTCAGCCAGAAGCTGCTCGGTGTCATMGATGAGAAGAGGTCAGTGCGTCCTTTCCTTCG







::::::::::::::Rv142T7.seq::::::::::::::







CAGGCATGCAAGCTTTTTGAGCGTCTCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGC




(SEQ ID NO 85)







CCACCCTCATTGGCGATGGCGCCGACGATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTT







GCGGACGGTCCCGACGCTGGTCGCGGTTGCGCCGCCAAAGCGGCGGGTCGGGTGCCATCATGAATGCCTCACCGCCGCCGCACTGCACGGCCAGTGCCCCGGCQAT







GTCAGCCATCGGGACATCATGCTCGCGTTCATACTGCTCGACCAGTCCGCGGAACAGCTCCATTCCACCGCCCAACGC






Clone Rv143




::::::::::::::Rv143SP6.seq::::::::::::::







ATACTCAAGCTTTTGGCTGGGTCGGCTTCCAATTCAGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCNCCGCACACCCCACTGGCCCGGGTGTTTTCGCCCCG




(SEQ ID NO. 86)







AACCCGGATCATGGTGAGCGAAAAGGAGATTCNCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCG







CAGTCCCGCTCCGTCGACGTCTCCGACGATCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCACAAGGTGATTCTGT







CCCGTTGTGTCCAAGTGCCTTTCGCGATCGACTTTCCGTTGACCTACCGGCTGGGGCGTCGGCACAACACCCCGGTGAGGTCGTTTTTGTTGCAGTTGGGCGGAAT







CCGTGCTCTGGGTTACAGCCCCGAACTCGTCACGGCGGTGCGCCGCCGAC







::::::::::::::Rv143T7.seq::::::::::::::







CAGGCATGCAAGCTTCAACCTATTGACGCATTGTGCGAACTGACGGCGCCCGCGCATGGCCAATCCGGAAGACCATCATTGGCCAGTGGCCGGGCGCTAACAGGTT




(SEQ ID NO. 87)







CCAGCCCCCCACCAGTGCCCCTCGAACATGCGGTGCAACCCATTCGCAGGCCGGCAGGGAAAGCACCGCGGAAGCCGCAAAGGGCTGCAGTTCCGCGCCCAATAGT







GTCGTCCGCAACCAGATGCGCTCGAAAACCGCCGCCGGCAGTCAGCGCACCCGACGCGAGGTCGAGAGACGTCGTCAGCGCGCCCACATGGGGTGCCAATCGGCAC







GGCAGGTAGGCCGCGCGCAACCCCAACGGGTGGTGCATGCCACGGTCCGCAGGAGGCCACCACCC






Clone Rv144




::::::::::::::Rv144SP6.seq::::::::::::::







ATACTCAAGCTTCCCGGCCGCAGGTGACGGCGCGGCCTAGCGCCACTTGATGCCGCACCCGATCGACGGNCGTTCGGTCGGGGTTGACTGGCCGCCCGGCGAAGG




(SEQ ID NO. 88)







GCGTCAACCGCGGCCCGGACGTCGGCGGCCGTCACCGGTCGGCCATTGCCCGGCGGGAGTCGTCGAGCTGACCACGGTAGACAAGTCGGCGCTGGCCGTCGAAGA







CAAACGTGTCGGGTGTGCAGGCCGCGGAGAAGGCGCNGGCGACGTCTCGGGTTTCGTCGTAGAGATACGGGAACGTCCAGCCGTGGCGGCGGCCTCGGCGACCAT







CTGATCGGGCCCGTCCTGCGGGTAGGTGACCACGTCTTACTGGAGATACCGACCATCGGGACCCTTTGATCGGCGAGGTCCCGGCCGACCGTGGCCAATCCGGCG







GCGACGTGTCGCCCGTACCGGCCAGTGGTTC







::::::::::::::Rv144T7.seq::::::::::::::







CAGGCATGCAAGCTTTANCANCATCAACCCCGCCCCGCACCAGCACCGACACGATGTCGATGCCATCGAGGTGAATGTCGAACTGGCNCAAACCATCTGGCGACCG




(SEQ ID NO. 89)







CGACCACCGGCAACATGGGTACCGGCGATTTCCGGTGCCAATGCCGACCCGACGGGCCGCTCTCACCGCAGGTGACCTCGATCACCGAGACCAGCCGGCCGTTATA







CTCACGCACCCCTACCGTGTCACGCCCAAAACGGCGCTGGTGGTCGATTGCCGGAGTGCACCCCGCACCCAGTGTCGTGCCCGGATCCGCCGACCAATCCCGCACC







GGCTG






Clone Rv145




::::::::::::::Rv145T7.seq::::::::::::::







ATATTCAACCTTGCACACATTGACGATACCTTGGTCACGAGACCCCAAAAGCTGGCCTCCACCGCGCGCCGGGGACCACGGTCATACCTTGANNCNGCTTTCGATC




(SEQ ID NO. 90)







GTTGATGCTGCGTCTTGGTCCGCGGAAACCGCAGGCTGGCATATGCACGTGGGCGCACTGGCGATCTGCGATCCCCACCGATTCGCCCGAATACAGCTTTCAGCGG







CTCCCCCAAGTTGATCATCGACCGGCTGCCGGATATCCCGCACTTGCGGTGGCGGGTCACCGGCGCCCCGCTCGGACTGGACCGGCCGTGGTTCGTCGAGGACCACG







AAC







::::::::::::::Rv145T7.seq::::::::::::::







CAGGCATGCAAGCTTCATGCCCGCGGCATGATAGCCACATGCACGCAATCGAACTCAGCGAAACCGGCGGGCCAGGCGTCTTACGCCACCTCACCAGCGCGCAACC




(SEQ ID NO. 91)







TCAACCCGGGCACGGAGACCTCCTGATC






Clone Rv146




::::::::::::::Rv146SP67.seq::::::::::::::







ATACTCAAGCTTGATTTTGATCATCATGATGATCATCACCCGAATTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGG




(SEQ ID NO. 92)







CTTTCCGTATTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCNTGGCGGTGGGATCCGACTACAATCTGC







TGCTGATTTCCCGGTTGAAAGAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGG&AGTGGTGACGGCTGCCGGCATGGTGTT







CGCCGTTACCATGTCGTTGTTTGTGTTCAGCGATTTGCGAATTATTGGTCAGATCGGTACCACCATCGGCCTGGGCTTGCTGTTCGACACCCTCGTCGTGCCTCGT







TCATGAAACCGTCCATTGCTGCCCTGCTGGGACCTGGTTCTGGTGGCCGCTACGGGTGCGCCGCGCCCGGCAGTCAAATCTTCCGCCG







::::::::::::::Rv146T7.seq::::::::::::::







CAGGCATGCAAGCTTGGCGTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACC




(SEQ ID NO. 93)







TCGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGGGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCG







GATCGCGGTGATCGTCGATGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAACGTGGTGCTGGCGGTCCCC







ATCGGCCCAGACGACATCGTGGCGAGA






Clone Rv147




::::::::::::::Rv147SP6.seq::::::::::::::







ATACTCAAGCTTTTACGGTGATCGCGATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCG




(SEQ ID NO. 94)







GGTGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGAC







TGTCCATGGACAACAGCGCGTTCTCCACGACCGGGCCCGGGTGTGGGGTGTTTCGGCGACCGGCAGCCANGTGGTCCACACTGCCGAAG







::::::::::::::Rv147T7.seq::::::::::::::







TAGTCGCTGACCGGTGCAGGTTTCGACNATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTACGAGCAAA




(SEQ ID NO. 95)







TCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCTANCNTGTGTGCCGCGGATTATCAGG







ACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGG






Clone Rv148




::::::::::::::Rv148SP6.seq::::::::::::::







ATACTCAAGCTTTCCGCCGATACCCGCCCATGTCGCGCACATCCAGAACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAGTGCGGATGATCGGGCCGCCT




(SEQ ID NO. 96)







ACGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACGGCACGGGGTGAAGGC







CTATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGCCGGAGACAAAAGTATCGCTAAGGTCACCGCGATCACGAGCATGGTGATCGCAGCAATGTTG







CTAGTGATCTAATCGCCCCGTAATTACCGCGGTTCTCGTCTTGATCATGGTCGGCATCGACCTCGGCGCAATCCGCGGATTCNTCGCCTTGTCGCCGACCACAACA







TTTTCAGCCTTTCAACATTTGCGACAACCTGCTCGTTCTCATGGCGATTGCNGCGAAC







::::::::::::::Rv148T7.seq::::::::::::::







CAGGCATGCAAGCTTGGCGTGCCGTTCCAACCCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCTGGACACAA




(SEQ ID NO. 97)







TCGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCACGTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCG







GATCGCGGTGATCGTCGATGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCG







ATCGGCCCAGACGACATCGTGGCAGATTCGCCGGTACGCCGATGAAGTGGTGTTGTTTGGCGACCCGGCGTTGTT






Clone Rv149




::::::::::::::Rv149SP6.seq::::::::::::::







ATACTCAAGCTTTGGCATTGTGCACATTTTCCACCCGTGCTCTATTAATGCTGAGCCGCTAATTGTGACCCCAGTCGGGAAACACGCGGAGCACCAAATTCACCGC




(SEQ ID NO. 98)







AGCGGCCGGGGCGGTTCAACTCACCATGGATCGCTCTCGTCGTCTGGTGCTGGACAATCGTCGCTGTAGCGCGTCGCGAACACCTCAGCTTCTGCTGCCGCGGCTT







CTTCCGGCGATGGTAACCCCCAGGTTTCGCCCACGGTCTTACGTAGCAGTGCGACGCGGTGTTCATCTGCATCGACCTGTTGACTCATCCTGTCAAGGATGAAGGC







GTACTGGGCCGACTGCGCCTTCTGCCGCGCCAGGTCGGCAATCACCAGGATCTCAGAAACGAGCTGCGACTCACTCTTCCAGGCCACCCTGGCCGAAAGCTCGACA







TGGTCAATCCGGCCG







::::::::::::::Rv149T7.seq::::::::::::::







CAGGCATGCAAGCTTGCGGGCCGGAGTGGTTTCGACGGCCGCTCGCTTCTCGGCATCGGTTTGGGCTGTCACCAGCAGTTGGTAGTTCTTCACGTACTGTTGTTCG




(SEQ ID NO. 99)







AGCGTCGAGCCGCCGCGCGTGTCGAGGTCGCCGGACGCGTATCCCGCCAGGCCGGTCAGGGTGCCCTTCCAGTCCACGCCGCTGTGGTCGGCGAACCGCTTATCTT







CAATCGAGACGATCGCCAGCTTCATCGTGTTGGCGATCTTGTCCGAGGGCACCTCGAACCGGCGCTGCGAGTACAGCCACGCGATCGTGTTGCCCTTCGCGTCGAC







CATCGTCGATACCGCAGGCACTTGCCCCTC






Clone Rv14




::::::::::::::Rv14SP6.seq::::::::::::::







ATACTCAAGCTTCCCGGCGGCCAGTACCGAAAGCGCGAACAGCTCGCGGCAGCCCACGACGTGCTGCGTCGGATTGCCGGCGGCGAAATCAATTCCAGGCAGCTCC




(SEQ ID NO. 100)







CGGACAATGCGGCTCTGCTGGCCCGCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGC







TTGATGCCCGGTCGGCAAGCCCGGCAGTTGCCAAACCCAGCGTGATCAGGGTCGGCTCGCGAGTTCGGCGAAGAAGTGGCTCGGCTGATCACCTACCATCGGCCAG







GATCTGCGTGTCATCACAACGCTCGCCAAGGAGGTTGTTGTGGTGCTATCGACGGCCTTTAGCCAGATGTTCGGAATCGACTATCCGATAGTGTCCGCGCCAATGG







ACTTGATCGCCG







::::::::::::::Rv14T7.seq::::::::::::::







AGCTTCGGTGTAGCCGATCACCGGAAGCCGCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCG




(SEQ ID NO. 101)







CCGACGGTGCCGGTTCGC&AGCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGT







TGTCGCTTTCTACGGTCACCGACGCCGTGACCGTAGTCGCCCGGTGCGCTCGGCCGAGAAGTTGCACCGCCACCACCGCGACACCGTCTTGCACGCGGACCCCACC







CCCGGATCGGTTGTTGGCCAAGGTAATTGGGTCATTCCATTTGACGGGACGCCGACCCCGCAGCCCCAGTACCGCCCACGACCACGCCGGCTGACCCACCACTGTA







CGAACACCAAGGCGACGCCGA






Clone Rv15




::::::::::::::Rv150SP6.seq::::::::::::::







ATACTCAAGCTTCGGTGGCTTCGCCCGCCCTGCCGGGTGGACTTCATGACAACGCGGGGGCGATTACCCCCGCTACCGCCAGCAGCATGACGGCGGTACC7AACAC




(SEQ ID NO. 102)







CGCCCGGATGCCTCGCACGTGCCTCGATGTGCTCACGGAATCGCCCCGGCACCGCGATCTCGAGGATCACCAGCGTTACCCCCGGCAGCGCGACACCGACAATTCC







GTACACCGCCACGCCGATCCGGCCCTGGGCCAGCTGATTGGAGCTGGCG







::::::::::::::Rv150T7.seq::::::::::::::







CAGGCATGCAAGCTTCCACATGTACGGATCCACGAACATCCCGTTGAACTGACAGGTGCGGCCCGGCTCGATCAGGCCGGCCACTTGTTCTACGCGGTTACCGAAG




(SEQ ID NO. 103)







ATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGCCCAGTGCCCGGCGTTGGCCGCCGCGGCGACGATCTTGGCGTCCACGGTGGTCCGGGTCTTGCCCGCTA







GCACGATCCGCGAGTCGGCCGGTCACCCGGGT






Clone Rv151




::::::::::::::Rv151SP6.seq::::::::::::::







ATACTCAAGCTTTCCAAGTCCCAAGTGTCGATCATGGCCAAAGAGCTCGACAAAGCCGTAGAGGCGTTTCGGACCCGCCCGCTCGATGCCGGCCCGTATACCTTCC




(SEQ ID NO. 104)







TCGCCGCCGACGCCCTGGTGCTCAAGGTGCGCGAGGCAGGCCGCGTCGTCGGGGTGCACACCTTGATCGCCACCGGCGTCAACGCCGAGGGCTACCGAAAGATCCT







GGGCATCCAGGTCACCTCCGCCGAAGACGGGGCCGGCTGGCTGGCGTTCTTCCGCGACCTGGTCGCCCGCGGCCTGTCCGGGGTCGCGCTGGTCACCAGCGACGCC







CACGCCGGCCTGGTGGCCGCGATCGGGGCCACCCTGCCCGCAGCGTGGCAGCGCT







::::::::::::::Rv151T7.seq::::::::::::::







CAGGCATGCAAGCTTCACACGTAGGCGCGTCGATAAATGACTCCGCCGCGCTTCGCACATCCTCGTAGCGATCCTTGGCGAGCAGGTCAACCGGGCGCTGCCCGT




(SEQ ID NO. 105)







CGAGGAGCCGGTTTTTGGCGTGCAGCCACTGGCCGACACCTCGGGGGGTAGGCGAATCCGAGAGCAGGAGGACGAGGTCACGGAGCTGCGCCAGCCGGTCGTACCG







CTCAGGGCGGATGTCGCCGGTCCGCCACCCGCGTACCGCCCGATCGGACACCTGTATGACCGCGGCGACGTC






Clone Rv152




::::::::::::::Rv152SP6.seq::::::::::::::







CGCGGCGGCGCATTACCCCCGCTACCGTCAGCAGCTTGACGGCGGTAGCGAACACCGCCGGATGCAGCGCAGGTGCGTCTATGTGCACACGGAATCGCCCCGGCAC




(SEQ ID NO. 106)







CGCGATCTCGAGGATCACCAGTGCCCGCCCCCTG







::::::::::::::Rv152T7.seq::::::::::::::







GGGATCGAGGAACAGCGCGTTGAACTGATAGGTGCGGCCGGCTCGAGCAGGCCGGCCATTTGTTCGATGCGGTTACCGAAGATCTCTTCGGTGACCTGCCCGCCG




(SEQ ID NO. 107)







CCGCCAGCTCGGCCCAGTGCCCGGCGTTGGCCGCCGCGGCCGACGATCTTGGCGTCCACGGTGGTCGGGGTCATGCCCGCGAGCAGGATCGGCGAGCGGCCGGTCA







GCCGGGTGAACTTCGTCGAGAGCTTGACCCTG CGTCGGGGAGGCGAACCACGGTCGGTGCGTATCTCGACCAGGCCCGGGCAACCTCGGGGGTGGCGCCGACGGT







GAACAGGTTGCGCTGGCCACCACGGGTAGCCGCCGGCACTATGCCGATGCCCAGGCCGCGGATCACCGGTGCGGTCAGTCGGGTCAGGATGTCGCCCGGCCCCAGG







TCGAAGATCCAGCGGGCGCCGGCCGCGTGGACACNGGTGATCTCGTCCACCATCGACTTTTCTGATCA






Clone Rv153




::::::::::::::Rv153SP6.seq::::::::::::::







TAACTCAAGGCTTGCGTTGAGGCCCCAGGCCCATCGACGGTTTGGCGGCCTTAAATGCACTGAGGTCGTCAATTGACCCCACAGCGGAAATGCCGACTATTCGCAG




(SEQ ID NO. 108)







GCCTCCTTCGCCTTGGCTGCCGGAGAGGGGCTCCGCGGGAACCGCATGCAGGTATATGACCTCGGTTTCTCGGGTGCTACCGGGTGCCTTGTCGAGGATGAACTCG







GCGTTGGAATTGTCCAGCCGGCCCAATTCATCGAGCGCAGATTCGTACACATGGCCGGCGGCGACATACGCTTCACCGTGGATCTGCTCCACACGGAGCGGCCTGT







CGGGATCCTGCTCACGGGTAAAGGAACTTACNTGGCNCTCGGTGCC







::::::::::::::Rv153T7.seq:::::::::::::







CCTTCTGCGCCACCCACACCGTCAACGCCCGCGAAGTCGACGTCGTCCAGGCCATCGGCGGCCTCACGGATGGATTCGGCGCGGACGTGGTGATCGACGCCGTCGG




(SEQ ID NO. 109)







CCGACCGGAAACCTACCAGCAGGCCTTCTACGCCCGCGATCTCGCCGGAACCGTTGTGCTGGTGGGTGTGCCGACGCCCGACATGCGCCTGGACATGCCGCTGGTC







GACTTCTTCTCTCACGGCGGTGCGCTGAAGTCGTCGTGGTACGGCGATTGCCTGCCCGAAAGCGACTTCCCCACGCTGATCGACCTTGACCTGCATGGCCGGCTGC







CGCTGCAGCGGTTCGTTTCCGAACGCATCGGGCTCGAAGACGTCGAGGAGGCGTTCCACAAGATGCATGGCGGCAAGGTATTGCGTTCGGTGGTGATGTTGTGATG







GCCGCCATCGAGCGCGTCATCACCCACGG






Clone Rv154




::::::::::::::Rv154SP6.seq:::::::::::::







ATACTCAAGCTTGATTTTGATCATCATGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGG




(SEQ ID NO. 110)







CTTTCCGTATTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGC







TGCTGATTTCCCGGTTGAAAAAAGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTTACCGCTGCCGGCATGGTGTT







CGCCGTTACCA







::::::::::::::Rv154T7.seq:::::::::::::







ATTGNCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCGGTCGAACGCAAG




(SEQ ID NO. 111)







CAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACGGCATCGCCACCG







GAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAGACGACATCGTGGCGAGATTCGCCGG







GTACGCCGATGAGGTGGTGTGTTTGGCGACGCCGGCGTTGTTCTTCGCCGTCGGGCAGGGTTACCGCAACTTCACCCAGACCTCCGACGAAGAAGTGGTGGCGTTT







TCTGGATCGTGCTC






Clone Rv155




:::::::::::::Rv155SP6.seq:::::::::::::







ATACTCAAGCTTTTCCCGTCCGTCATCGCCCAAGCGCGTGAGGCCGAAGCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGG




(SEQ ID NO. 112)







GGACGCCCGACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCG







CAGCCCGACCCTGCTGGCAAAGATCATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAACACCGCCAG







CTCGGCTTCGAGTTCGGCACTTTCAGTGACCGGTTCAACCGGCTCGAANAGGCGCTACAGATCCTCGAGCCAATGGTCAAGGGTGAGCGCCAACGTTTTTCGGCGA







TTGGTACCCACCGA







:::::::::::::Rv155T7.seq:::::::::::::







CGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGAC




(SEQ ID NO. 113)







CCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACG







ATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACT







TGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCGCCGCCCAATGTTGCGACTCCGTTCGGGTTGTTCCCAGAGGTCAGCCCGGT







CGTCATCGCCGACGCTCTCGTCGCCGGGACCAGCAGGGAATCGGCGATTTCGCCTACA






Clone Rv156




:::::::::::::Rv156SP6.seq:::::::::::::







TCGCCACCGCACCGCGGCGAACGCTCAAAGGCACCTACTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTA




(SEQ ID NO. 114)







CCACCGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCGATCCATTCGAG







GTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAGGTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGGTGTGGACGAAACAGATCTTCTGTCCG







ACGACTACACCACCACCCAGGCCATCGCCGCCGCCCGCGATGCCAACTTCGACGCCGTACTGGCCCCGGCGGCGGCGCTCCCCGGTTGTCAAACACTTTGCCGTGT







AATCCCATGACGTATCTGCGCAACGACGTGCNCAACNGTGGCTGATGTCNGTGGTGTTGTGGGGTGGGC







:::::::::::::Rv156T7.seq:::::::::::::







TCGCCACCGCACCGCGGCGAACGCTCAAAGGCACCTACTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTA




(SEQ ID NO. 115)







CCACCGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCGATCCATTCGAG







GTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAGGTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGGTGTGGACGAAACAGATCTTCTGTCCG







ACGACTACACCACCACCCAGGCCATCGCCGCCGCCCGCGATGCCAACTTCGACGCCGTACTGGCCCCGGCGGCGGCGCTCCCCGGTTGTCAAACACTTTGCCGTGT







TCGTTCACGCACTGCCCAACATCGAGCCCGA






Clone Rv157




:::::::::::::Rv157SP6.seq:::::::::::::







ATGAAATAAGAAGAGCACATCCCTCAGTCGGTTATCATCACTAGCGCTCGCCGCACCCGTGTAACCGATCATAGCGAGCGAACTGGCGAGGAAGCAAAGAATATCT




(SEQ ID NO. 116)







GTTCTGTCAGATAGCTCTTACGCTCAGCGCAAGAAGAAATATCCCCCGCGGGAACAACTCCAGGTAGAGGTACACACGCGGATAGCCAATTCAGAGTAATAAACTG







TGACACTCACACCCTCATCAATGATGACGAACTACACCCCGATATCCGGTCACATGACGAAGGGAAAGAGAAGGATATCATCTGTGACAAACTGCCCTCAAATTTG







GCTTCCTTAA






Clone Rv159




:::::::::::::Rv159SP6.seq:::::::::::::







ATACTCAAGCTTGTCGAACTCCTTCTTGAATACCGGCCGGCCATCCACAGATGCCCGGAAGAACTTCCAGGTACCCATGGCGGCTGGATCAGGGGGCGGCACAGTT




(SEQ ID NO. 117)







GGTCTTGTCCTGCCTCGAGTGGCGTCGTTGTCCGGCTTGGACGGGGCTCCGACGGTACCGGAGGGCAGCGACAAAACACTTATGCACTTGGGCGACCCGCCGAGAC







GGTGCGACACCCATCCCGACGGCACAAGCTCAGCCGCGGCCGCTCTTGTTCTTCGTCGGATCGACATTCACCCACTTCTGACCGGGCTTGGGCGAAGGAAGCAGAA







:::::::::::::Rv159T7.seq:::::::::::::







GGTATAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTACGAG




(SEQ ID NO. 118)







CAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCATGTGTGCCGCGGATTAT







CAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGAGGTCAGCGAATTCTCGTGGCA







GCTCGAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACGATGGCGCAGGTTACGGTCGCGCGGGGTGCGGCCCTGGCGGCGGCCCA






Clone Rv15




:::::::::::::Rv15SP6D2.seq:::::::::::::







GACACTATATNATACTCAAGCTTCAGGTCAATGTGCGCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGANCCCTNTCTAGA




(SEQ ID NO. 119)







:::::::::::::Rv15T7.seq:::::::::::::







CTGTAGCCACCTGTTGCCATCCCCGTCATGCCCGACTCTGGTCATCTCGGATCCGCTGACACCCCGCTAAGGCTGCTCCTCTCGGTGCATTACCTCACCGACGGCG




(SEQ ID NO. 120)







AACNCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCCGGCTAACTTCACCGTCAGCTTGGACGGCGGCGCTACCGTCGATGGCGCCAGCGGGGCGAT







GGCCGGGCCCGGCGACCGATTCGTCNTCANCCTGTCGCGTGAACTTGCCGACGTCATCGTGGTCGGTGTGGGCACCGTGCGCATTGAGGGCTACTCCGGCGTCCGG







ATGGGTGTCGTCAAGCGCCCGCACCGGCAGGCCCGA






Clone Rv160




:::::::::::::Rv160SP6.seq:::::::::::::







ATACTCAAGCTTCGCACGCTCGGCGCGCGCGGTACCGCCCAGGTCGCCCAACAGATCGTCGATGTTCGCGTCGTCCGCCTCGCGCACGTGGTCTGTCACCAGTCAA




(SEQ ID NO. 121)







CGTTAACGCCGCCGCACATGTCCTGCGGCCGGGCAAAAACGTGAAAAACGAGCGGGCGACTGCNATGTCATGACACCGACGGCCGCCGATGGGCCCAGGGTCTGGC







AAATTCGATCTGTGCGGCCAGTGCCAGCAGCGTCGCCTCGTCATACGGCCGGCCGACGAGTTGAACCGACATGGGCAGGCCGTCGCCGTCGAAGTCCCACGGCACC







ACGGGCGCGGGCTGGCCGGTCAGATTCCAAAATTGAAAGTACGGAACCGCTGCACCACCAA







:::::::::::::Rv160T7.seq:::::::::::::







ATCGTTTCGACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCAGCTCGCTTGCGGCGCTGCAGCA




(SEQ ID NO. 122)







GCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGAAATCACGGTGGCGGTAGCCGTTGCGCTGATTGGA







CCGCTCATCGCTGCGTTCGCGGTAGCCCGCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGGCGATGAACGTCGAGAGCAGCCCGCGCAGCAGATCCGGG







CTCGCCTGTGCGAGTTGGTCAGCCAGAAGCTGCTCGGTGTCGATAAGATGANAAGAAGTCATTGCGTTATTTCCT






Clone Rv161




:::::::::::::Rv161SP6.seq:::::::::::::







ATACTCAAGCTTGGGTGTTGCCGATCACCGGAAGCCGCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGG




(SEQ ID NO. 123)







GTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACNACGTCA







ATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTAGTCGCCCGGTGCGCTCGGCCGAGAAGTTGCACCGCCACCACCGCGACAACGTCTTGCACGCGGA







CGCCACCCCCCGGAT







:::::::::::::Rv161T7.seq:::::::::::::







GCGCNAACAGCTCGCGGCAGCCCACGACGTGCTGCGTCGGATTGCCGGCGGCGAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCCGCAACGAA




(SEQ ID NO. 124)







GGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAGCCCGGCAGTTGCC







AAACCCAGCGTGATCAGGCTCGGCTCGCGAGTTCGGCGAAAAAGTGGCTCGCCTGATCACCTACCATCGGCCAGGATCTGCGTGTCATCACGACGCTCGCCAAGGA







GGTTGTTGTGGTGCTATCGACGGCCTTTAGCCAGATGTTCGGAATCGACTATCCGATAGTGTCCGCGCCAATGGACTTGATCGCCGGCGGTGAGCTGGCTGCCGCN







GT






Clone Rv162




:::::::::::::Rv162SP6.seq:::::::::::::







ATACTCAAGCTTTCTCCGATACCCGCCATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCTA




(SEQ ID NO. 125)







CGTCGTGGTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGGCC







TATGTCACCGGTCCGGCAGCACTCAATGCCGACCAGGCCGAGGCCGGAAACAAAAGTATCGCTAAGGTCACCGCGATCACGAACATGGTGATCGCAGCAATGTTGC







TAGTGATCTATCGCTCCG







:::::::::::::Rv162T7.seq:::::::::::::







CCATGAGCACCGCCAGCCGAGCACGAGGCCAAACTCCGCCGACGCAGGCCGGTTGGACTTGTCGTGCTGGACAAGGGGTTTAGCCGCCGAAGCAGTGACGTACATC




(SEQ ID NO. 126)







GGCGAAGAGCAGTTCGCCTGTCGACCGACGGCGCAAACCGTGAGGCTAGGGAAGCGAGGAGCACATGGCCGCCGACCCGCAATGTACACGCTGCAAGCAAACCATC







GAACCCGGATGGCTATACATCACCGCCCATCGCCGCGGTCAAGCCGGGATCGTCGATGACGGCGCAGTACTGATTCACGTGCCCGGTGAATGCCGCACCCCGGGGA







GCACTTTCCGCCAAAACTAACCCGGTTGG






Clone Rv163




:::::::::::::Rv163SP6.seq:::::::::::::







CGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAGGAGTGCTGAACCGTAGTCGAAGTGGGCGGCGTCAGACTCCA




(SEQ ID NO. 127)







CCCAGCCAGCAGGCAGCGCGAANCTGAATCCTCCAACCGGGTTGTCNATCCGGACAGGTTGGGGTGCGTTTGGGGCAATNACAGGTGGCGGCGGTGCGTTCGGGTC







GGCCGGCGGAGGTGCTGCNTTGGGATCCCCGGCTGGGCATTCGGCNTGTTGGCGGCGGCCGGTGGTGGGGGGGGCAACACGTGTCNCCGGTGCGGGTGGCCCT







:::::::::::::Rv163T7.seq:::::::::::::







CCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTC




(SEQ ID NO. 128)







CAACTACTTCATCCTGACGCCGGAACAANTTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTG







CCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGANACCCACTGGCGAACCTGGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCC







GGCCTATGGTTATTCGACCTCGCCGCCCAAATGTTG






Clone Rv164




:::::::::::::Rv164SP6.seq:::::::::::::







AGCTTCCCGAGTTCGGCTTTGGATCAAGACCCCAGTCCGCGGGCGCGATCCGGCNGCTCGGTGACTACATCAAGCCACAAATCGACGGCTTTCGGGGTGCCGATAC




(SEQ ID NO. 129)







CGATGACGTGGCGGATGTCGAGTGTTGAGTTCTCGGCGGGGCGGATGCTCACCTGGCGATCACCTGCCTCTCGTTGACGATCGATCGTCTATGCCGCCGTCTCTGC







GGGAACAGGCCNCCAGTACATCGCCACAGACGGGATCCACCCGCATTTCGGCTACGGTTGCTCGTTTCGGTGTTCGGACTAGTCGGTCCTGGTGACGTGCCGGTGA







TGCGGACCGGTCCTAGCACTGACCAATGGCCAAAATGCGGGC







:::::::::::::Rv164T7.seq:::::::::::::







CGGGGGGCCTCTTAATAGTGTAGGAAAGAAGCTCTACATATTCAGGAGGATTCACCATGGCTCGTGCGGTCGGGATCGACCTCGGGACCACCAACTCCGTCGTCTC




(SEQ ID NO. 130)







GGTTCTGGAAGGTGGCGACCCGGTCGTCGTCGCCAACTCCGAGGGCTCCAGGACCACCCCGTCAATTGTCGCGTTCGCCCGCAACGGTGAGGTGCTGGTCTGCCAG







CCCGCCAAGAACCAGGCAGTGACCAACGTCGATCGCACCGTGCGCTCGGTCAAGCGACACATGGGCAGCGACTGGTCCATAGAGATTGACGGCAAGAAATACACCG







CGCCGGAGATCAGCGCCCGCATTCTGATGAAGCTGAAGCGCGACGCCGAGGCCTACCTCGGTGAGGACATTACCGACGCGGTTATCACGACGCCCGCCTACTTCAA







TGACGCCCAGCGTCAGGCCACCAAGGACCCGGCCAGATCGCCGGTCTCACGTGCTGCGG






Clone Rv165




:::::::::::::Rv165SP6.seq:::::::::::::







ATACTCAAGCTTCATAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCACGCA




(SEQ ID NO. 131)







GGGCCGCGGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCTTCGCGTTCACTAAT







CGCGGTGCTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGCGACCAGCTGCTCCACCACGGACCGCAGCGATGCCGTCACCTCACCCGTCCAGCGGTCCACCACG







ACACGGTCGTGCACCAGCGCGCGGGCATTCACCACCCAGGCGGTCACCGCCAGGCCGATCGCCACACCCGCCACCATCCCCGATGCAGCCAGGCCGGGAGTAAGA







:::::::::::::Rv165T7.seq:::::::::::::







CTGGTGCTGGACGGAGCCTAGTACAACTTCCTCTCCAATGCTCTTGCCCCGATCGCGGCGACCAGGATGACCCAGGACATCCTGCCGCCCGAAGTACTGGAAAAGC




(SEQ ID NO. 132)







TCACACCCGAGTTCGTCGCACCGGTGGTGGCCTACCTGTGCACCGAGGAGTGTGCCGACAACCCATCGGTGTACGTCGTCAGTGGTGGTTAGGTGCAGCGAGTTGC







GCTGTTTGGCAACGACGGCGCCAACTTCGACAAACCGCCGTCNGTACAAGATGTTGCGGCGCGGTGGGCCGAGATCNCCGATCTGTCCGGTGCGAAAATTGCTGGA







TTCAAGTTGTAGAACTAAAT






Clone Rv166




:::::::::::::Rv166SP6.seq:::::::::::::







ATACTCAAGCTTTTCCGGCGTCGTCCACCTGACCCAAAAAGCGCAGGTGCGCCGCCAAACGGCCCGCCTGGCCGCGCAACTGGTCGGCGTCGCCGTGGCCGACAAT




(SEQ ID NO. 133)







CAGTAGCTGGACATCCGGAAACCGCTGCACCACCTTCGGCAGCGCGTCAAGCAAAAACGGCCATTCC







:::::::::::::Rv166T7.seq:::::::::::::







TTTCAGATCTCATTTTTATGACATGACTGGAGATCTGTCTAGATTGCAGCTCCTGTGAGCGTGGGTACCGGATTCAAGCCGGTCGGTCACGCCGCGGTGGTACCGG




(SEQ ID NO. 134)







CTTTGCGGCAGTGCTCGGCCTCGAGTTCGGCGATCGCGCGCGAAGTGCGTTTCGCGCACCAAGATCGCGGCCTAATGGCCGGCGATGACCGCGATGACCAGCGCGA







TCCAGGAAAAACCGTTCCAACCAGTGCTGGGCGGCCATCCCCG






Clone Rv167




:::::::::::::Rv167SP6.seq:::::::::::::







ATACTCAAGCTTCCCGACCACAAGTTGAACAGCACCGATTTCGGCGAGCACTTCGTCAACTTCCAGGGTGCCCGCACCAAGTATTTCGACAAGTATTTCCGTCGGG




(SEQ ID NO. 135)







CCGCCGCCGCCGGCGCGCGGCAGGTGGTCATCCTGGCGGCGGGGCTGGACTCCCGCGCGTACCGGCTGCCTTGGCCCGACGGGACCACGGTTTTTGAGCTGGACCG







CCCGCAGGTCCTTGATTTCAAGCGCGAGGTGCTCGCCAGCCACGGTGCCCAACCGCGCGCCCTGCGCCCGCGA







:::::::::::::Rv167T7.seq:::::::::::::







GTGTGCTGTCAATTCAGAGCTGAGCCTGATGCACTCAACTTACTGAGCATGCTAACGCTGGTCGTGCGGGTCTTGTTCCCGCGTGTCGGCAGGGCACACGCTCGGG




(SEQ ID NO. 136)







GCGTAGCTGGGAGAGGCCCCGGTCAAGCCCGGAGAGCAGTGCTCAGTCCGCCAGCTTGACCGACTTTCGATGAGAACGCGCTTCTCGCCGTATTGAACTGGCGTGC







TGACGGTCGCTGAGCAGCGCTCGCCGAGTGCGGCCGCTGATTCTTTCATCGAGCCAGGAGGCGCATTCGTGTTCGGCCGCCTGCGGGTCGGCCCCATCGTCGACGC







GATCCGTCACCCACTCCTCGATCAGGTCTGCCTCATCGAACGGGCCAACGGTGCTGTCGGAGTATGTGTGCGTGGGCACGGCGAGCCGGGTGCTGTGGTACACCCA







CCGTTGCATGACCAAGTTGACGCCTGACTGGCTGAGCACCGCGATCCGCTCACAGGTCGGAACGTTGGTG






Clone Rv169




:::::::::::::Rv169SP.seq:::::::::::::







ATACTCAAGCTTTTGGTCTAGCCGGCCGAGCCCGATACAGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAGGAGT




(SEQ ID NO. 137)







GCTGAACCGTATGCGAAGTGGGCGGCGTCAGACTCCACCCAGCCAGCAGGCAGCGCGAAACTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGT







TTGGGGCAATGACAGGTGGCGGCGGTGCGTCCGGGTCGGCCGGCGGAAGTGCTGCGTTGGGATCGCCCGGCTGGGCATTCTGCGTGTTGGCGGCGGCCGGTGGTGG







GGGGGCAACAGGTGTCTCCGGTGCGGGTGGCGCTGCACC







:::::::::::::Rv169T7.seq:::::::::::::







GGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACG




(SEQ ID NO. 138)







CCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCA







GTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTG







ATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCGCCGCCCAATGTTGCGACTCCGTTCGGGTTGTTCCCAGAGGTCAGCCCGGTCGTCATCG







CCGACGCTCTCGTCGCCGGGACCCAGCACGGAAT






Clone Rv16




:::::::::::::Rv16SP6.seq:::::::::::::







TTCTNTCTTCCCNNATTCGTNNNTCTCNTACTACCNGGGCCNCAAAACACCTTGGCNAACGCTCAAAGGCGNTACNGGCACCAAGGCCCCACACGTCACCCTGTGA




(SEQ ID NO. 139)







CCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTACCACTGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTT







CCGCCNCTTTTTTTATGACGGGGTCGATCCATTCGAGGTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAGGTACTCGACCTCNCAGACGAGAGGACTCGA







TCCCATCTANGTGTGGACNAAACAGATCTTCTGTCCGACGACTACACACCACCCAGGCCATCGCCGCCGCCCGCGATGCCAACTTCNACNCCGTNCTGGCCCCGGC







GGCGGCGCTCCCCGGTTGTCAAACACCTGCCGTGTTCGTTCACNCACTGCCCAACATCNAGCCCGANCNATCCNAGGTCCGTCCAACGCCTCCGCGGCTCNCCAAC







CTNCTCCCNCTGATCNTCCGCACCAAACACATGCCCGACTCCNTGCNCCNATTGCTTGNATCCCT







:::::::::::::Rv16T7.seq:::::::::::::







CCGCTATCGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGTCCAAGATCACCCTCGCCC




(SEQ ID NO. 140)







AGACCTGCTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGGGTGTCCACACCGGAGGACCCGGCGTCGGCGCGGTTCGGCGAGACGTTGTGGGA







GTTCCTGCCCCGCAGTGTTATCGGCGGCTTGCGCTCGGCCGTTCATTTGGAGGCCCAACGGCTGCGTCGGCTCGGCGTCAGCCCCTGGAATCCCATGACGTATCTG







CGCAACGACGTGCTCAACGCGTGGCTGATGTCGGTGGTGTTGTGGGGTGGGCTGATCGCGGTCTTCGGCCCGGCGCTGATCCCGTTCGTCATCATCCAGGCAGTCT







TCGGCTTCAG






Clone Rv170




:::::::::::::Rv170:::::::::::::







ATACTCATGCTTGCCGAAGTTCCGATGGGTCGCGCCGGCGANCCCAGCGAAGTCGCTAGCGTGGCCGTGTTCTTGGCTTCGGATCTATCCTCGTACATGACCGGCA




(SEQ ID NO. 141)







CCGTGTTGGACGTGACTGGCGGCCGGTTCATATGACACCGAGATCATTGCCACGGTACGGCAATTCGTCAAGAAGGAAATCTTTCCCAATGCACCGGCCCTCGAAC







GTGGCAACAGCTACCCGCAAGAAATCGTCGATCGGCTGGGTGTTATTGGCTTCGTCGGTCGCCGGCTGCAAGGGTATCGACACCACCGAGTTCATTCTCCGGGCGT







GCC







:::::::::::::Rv170T7.seq:::::::::::::







GGCGTCAACGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAGCACCACGCCG




(SEQ ID NO. 142)







CGCCCCTCACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAATGCACCCGGA







CCAGCACGTCGTCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTCGTAGATGCTGGTGTAGCCGATGGCGCGAATCTC







CCATGACGAGTCGGAATCCGCGCCTCGGCG






Clone Rv171




:::::::::::::Rv171SP6.seq:::::::::::::







ATACTCAAGCTTCGGCCTCGCTGCAGGAGTGGGAGCCGCAGGGCTGGAAATCCGAAAAACGAGCCGGTGATCGCACTGTCGCCGATCGGGGCCGCACCTGGTTGGT




(SEQ ID NO. 143)







GTTACCGATGAATCCGCACCCAAAATGTGGCTGCGGTGGCGTTTCTTGACTCCTTGGCGTCGACTCTTGTGGCAGCCACCGAGCGGTTGGTCCAGGATCTGGATGG







GCAAAGTTGTGCGGCCCGGCCGGTGACGGCCGATGAGCTGACCGAGGTCGACAGCGCCGTGTTGGCTGACTTGGAACCGACATGGATTCGCCCCGGTTGGCGTCAC







CTCAAGCATTTCAATGGTTAT







:::::::::::::Rv171T7.seq:::::::::::::







ATGCGTCACCCCGATGCGCCCAGATCGGGGCTTCGCAAATAAAGCACGAACAGGCGGGCAAAACGTCTATCTCGGAGCCGGAAGGGCAATCAGCCGACCGTCGACG




(SEQ ID NO. 144)







AACGACACCGGCGATAACCACTTAGGCGTTGAACGGCCGGCCCAAACATTACGCCTCCGTTGATAAGGCTTTCGGTCTCTTCCCCGGTCATCCCAAGCAGGTTGCG







GCAAATTTGAACGCTTTCCTGTCCGGGCACCGGCCCCGGGCTTTGGGGTCCNTCCGA






Clone Rv172




:::::::::::::Rv172SP6.seq:::::::::::::







ATACTCAAGCTTCAATCGCGCCGCCACAATCCAAATATGCGTCTAGCGTCTCGATGAGCGTCGGTCCGGCATCGGCTAGGGGCCGCATCACGTCGGTATGCAGGGC




(SEQ ID NO: 145)







CACGATCGCCCAAGGCGTCGCCCATCAAGGGCGCGTTCGGGCAAAAATTCCCCTATCCAGCACGGGCCGCGGCGCTCCGCNCCAGCCGGCGACGGCGTTCATCCCG







GAGATCGCCTCGCTAGCGCTGCGGTGCGCCGCGGTCAGCATGGGCGCCGTGGGGCCGATGACCACCGGGGCGT







:::::::::::::Rv172T7.seq:::::::::::::







TTCGGCGGGTCTGTAGATTGCGGTCGGCCACCCCACAGGCACTCATGAACCGCAGCCCACGATCGATCTCGGTGG




(SEQ ID NO. 146)






Clone Rv173




:::::::::::::Rv173SP6.seq:::::::::::::







GCGCACCATCGCCAGTAGGTGCCCGTGGTCGGGCGCGTCGAGCCACCCGAGCGGAAACGCGAGTCCGAACAGCAACAGCAGGACGGGCGCAACCAGGGCGGTGACC




(SEQ ID NO. 147)







ATGCCCCCGGCGCTGAACATCAACCACAGGAAGGGCTCCGCCGAGCGTCCGCGCGACC







:::::::::::::Rv173T7.seq:::::::::::::







CATCGTCGAACTTCGGTCCGGGTTGNTAGNACCGCAGCACCAAACGCACCCACCGACCCCCACGCTTCACGCCAACCCTTTAGTTCATTGGCGTGAACAGCAGCGT




(SEQ ID NO. 148)







AGCCGGTTGCCCCGATATATGTGGAAAAATCGTTCGGACGTACAAAAAAAGTTCCTGACGCTGGCGTCAACTCGAAACTGCCTCGGAAGTCAATGATGATCCATCA







GTCAATATTAAAGTCG






Clone Rv174




:::::::::::::Rv174SP6.seq:::::::::::::







ATACTCAAGCTTGTCTGCTGCCTCAGCGTATGCATCCAACAGCGCATCGCGATCAACGATCAGGCGCGCCGATTTCGGGCCGCGGGCAGTGGCACTGGCCAGATGG




(SEQ ID NO. 149)







CCGTTTTTTTCGAGAAACTTCAACGCCTGAGCGCTGCTTCCCATCGAGAGACCGGTGGCCTCTACAACCGATGCGACAGTTGGACCGGCGATGTTCGCCAGCAGCG







CTTCACATACGGCAAGTNTGGCGCGG







:::::::::::::Rv174T7.seq:::::::::::::







TTGTCCAGGCGGGGAATCGGGCAGGGAGACGACACCTTCGTTCGGTTCGATCGTCGCGAACGGGTAGTTGGCCGCGACCACGTTGTTTCGGGTCAGCGCGTTGAAA




(SEQ ID NO. 150)







AGTGTCGACTTGCCGACGTTGGGCAGGCCCACGATCCCCAGGCTCAAGCTCACAGA






Clone Rv175




:::::::::::::Rv175SP6.seq:::::::::::::







ATACTCATGCTTGGCGCCTGGGTGGCAGCCCACCTGCCCACCACACGGACCGCGGTGCGGACGCGGCTGACGCGCCTGGTGGTCAGCATCGTGGCCGGTCTGCTGT




(SEQ ID NO. 151)







TGTATGCCAACTTCCCGCCGCGCAACTGCTGGTGGGCGGCGGTGGTTGCGCTCGCATTGCTGGCCTGGGTGCTGACCCNCCGCNCNACAACACCGGTGGGTGGGCT







GGGCTACGGCCTGCTATTCGGCCTGGTGTTCTACGTCTCGTTGTTGCCGTGGATCGGCGAGCTGGTGGGCCCCGGGCCCTGGTTGGCACTGGCGACGACGTNCGCG







CTGTTCCCCGGCATCTTCGGTCTGTTCGCCGTCGTGGTACCCTGTTGCCGGGTTGGCCC







:::::::::::::Rv175T7.seq:::::::::::::







CGCCAATTCACGATATCGTTAACCGATATCCCGAGCCGATAGCTGGCGGGCTCGGGTGGTGGCCAGCGGCGCTGCGACGAAAGGTGTGACCGTCATGAAACAGACA




(SEQ ID NO. 152)







CCACCGGCGGCCGTCGGCCGTCGTCACCTGCTCGAGATCTCAGCATCCGCAGCCGGTGTGATCGCGCTTTCGGCGTGTAGTGGGTCGCCGCCCGACCCCGGCAAAG







GCCGGCCCGACACAACCCCGGAACAGGAAGTCCCGGTCACCGCGCCCGAAGNACTTGATGCGCGAACNCGGAGTGCTCCAAACGCATCCTGCTGAT






Clone Rv176




:::::::::::::Rv176SP6.seq:::::::::::::







ATACTCAAGCTTGGGCACTGACTTCGGTACCCCCTCCGCCTTTGGCCAGCAGCAGCCACAGCGCGGTTCGCGGACCGAACGTGGACATCAATAGCCCGGAATCGGT




(SEQ ID NO. 153)







GTGTGCAAGTTGGTAAACGGTGTTGATCCCAAGCTTTGCCAGCCTTTTCGTAGTCTTGGGCCCCACACCCCACAGTGCTTCGACGGTACGGTCACCCATGATGGCC







ATCCAGTTGGCATCGGTGAGCTGATAAATGCCAGCTGGTTTCGCCAACCCGGTAGCGATCTTGGCGCGCTGCTTGTTGTCACTGATACCTATCGAGCAAGACAGCC







CGGTTTGCGACAAAATGACTTTTCGGATCTCTTCGGCGACTTCGATGGGGTCGTCGGGA







:::::::::::::Rv176T7.seq:::::::::::::







AAAGTCCTGTGCCGGTTCGCTAAACACCCGGCGGACACTCAGACGGTGCTGGTGGTGCGGCATGGCACCGCGGGCACCAAAGCGCACTTCTCCGGGGGACGACAGC




(SEQ ID NO. 154)







AAGCGACCGCTAGACAAGAGGGGTCGTGCGCAGGCAGAAACGTTGGTACACAGCTGCTGGCGTTCGGCGCCACCGATGTTTATGCCGCCGACCGGGTGCGCTGCCA







CCAGACGATGGAGCCACTCGCCGCGGAACTGAACGTGACCATACACA






Clone Rv177




:::::::::::::Rv177SP6.seq:::::::::::::







ATACTCAAGCTTGGGTTCCACGCCCGCGCAGCCACGCCGTCACCTTTCCACGAGACCTCACCTGCCGATCCGAAATGGAATCGGCCGTGACGGAATTGGCGCACCG




(SEQ ID NO. 155)







AACACCCAACGAGGTGGTGGCTTCGTCGCGAACCGTCACCCGAGTCGCGGCCACCGTGCGCACGGCGACGTTCTACACCCGCACCAAGATCCGAAAGCTGCAAGCT







CCCAGCACCGATCCCGACGTCATCACCGCTGCCGCCCGGCACGTCCTTGACCTATTCGAGCTGGATCGGCCCGTCCGGTTGCTGGGAGTGCGGTTAGAACTGGCCT







AGAACCGGCGGGCACACCGCNCCTCCCGCCCCGCAATTCTTGACCGCNCCGGCC







:::::::::::::Rv177T7.seq:::::::::::::







CGCGGTTGGCGTAGTTGGACGGGTCGCCCTCCGAGGCCAATGATGACGATGACCACGCCGATCACGATGGCCACCGAGAGGGACAACAACAGAAAGCTGACGAATC




(SEQ ID NO. 156)







CCTCCTTGGCGGCCGGGGCTTTGTGGTCGCCGGTCGCGATGGGCGCGAATTTACGGCCCGCTCCCCCAGGCCGCCGCGAAGCAGGGTCCCCAGCCAGTTGGCGTAG







GCGGAATTAACGATCAGCGCCACCGCGATAACCTGCCATGCCTCGGGCATATCGATGTGCGGCCAGAACAGGCCGAAC






Clone Rv178




:::::::::::::Rv178SP6.seq:::::::::::::







CCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGA




(SEQ ID NO. 157)







CAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCGACATCGTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCAG







CCGTTGCCGCCCGCAGCGGACGATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGCCGCGCTGGCGGGCTGATGAGCGCCCTGACCCCTCAATTCGGGT







CCAAGACCATCANCCTCTGCAACAACGGCGACCCGATTTGTTCNGACGGCAACCGGTGGCGAGCGCACCTAGGCTACGTGCCCGGGATGACCAACCAGGCGGCGCG







TTTCGTCGCGAGCAGGATCTAACCGCGAGCCGCCCATAGATTCCCG







:::::::::::::Rv178T7.seq:::::::::::::







TAANACCCGTGTAATTTGGGATGGGCAAAAAGGCCAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGA




(SEQ ID NO. 158)







ACGTACGGCGTTTCAACACGTCGCGTCNCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCNCCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCG







GGTAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCTACACGGCGATATGTTCGCCTCGCTG







CGCCGGTGGACCGGTGGGTCTATCCCGGAGACCGACNTCCCGATCGAAGCGACCGTCTCCTCGATGGACGCCGGCGGCGTCACCCTGGGTTTGCTCACCGCCTGGC







GTGGCCCCAA






Clone Rv179




:::::::::::::Rv179SP6.seq:::::::::::::







GTCCGCAAAAGACTCAGCGGCCGACTTTGCTCGCAGCTGGCGGTACCGCGCCACCGATTCGATGCCGTGGTCGCGGAAGAATGCCTCCCGAAATCGCACGGCCGAC




(SEQ ID NO. 159)







TCCAGTTCGGCGAGCATCCGCGATGCCACGTGCGGCTGCGCCCTGCCGGCCACGGCACCCACATGCGGCAGTTCGTCCACCTGGGCCAGCGCCCCGCCGCCGAAGT







CCAAACAATAGAACTGCACCCGGCCCGCATCGTGGGTAGCAGCCAACGCCATGATCAGCGTCCGCAGCGCGGTTGACTTGCCCGTTTGCGGTGCACCTACGACCGC







GACATTGCCTGCGGCCCCGGACAAGTCGATCGTCAGCGGCACCCN







:::::::::::::Rv179T7.seq:::::::::::::







CGTGGCCACGAACGCCGGGAGGGACANTCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAA




(SEQ ID NO. 160)







CATTCGGGGATGGCAGCAACCTGGCAGCTACCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACC







ATCGATGTGTGGATGCATCATCCGACGCAACGGTTCCTACACGGCGATATGTTCNCCTCGCTGCGCCGGTGGACCGGTGGGTCTATCCC






Clone Rv17




:::::::::::::Rv17SP6.seq:::::::::::::







ATACTCAAGCTTTGCGGCGGGCGCCGAAATGTGAACGCACCAAACCCGCCCGCTGCGGGTCGGCGGGCCACTCGACCTCGAATTTCGCCGCCGTGACCATCCAGCC




(SEQ ID NO. 161)







CGACGGCAGTTGGGCACCCGGCCCCCCGGTCGCGGCATAACTGTTGGCGTCGCCGTCATAAAGCTCGAACAGCACCGAAACCGACTCCACCACCGGCCGGTGCGCC







TCAAAATCCACGCCGATCTCCACATACCGGGAAAACGTCGGTGTCCCATCGGGTTTCGGCTTGCCCGCCAGCTGCACACCACCGGTGGCCTCGGCCACCTTCGCGG







CCTGAGCGCAGCTACNCATCCTGACGATCATCACCCCGCCCCCGGCTCACGCTTGGCCTCCGTGACCGCACGCATCGCCCGGTTGCGCGCACCGCGACGCCCGTAC







AGCCGCGCGCAC







:::::::::::::Rv17T7.seq:::::::::::::







AGCTTGCCGGGACTGCGGAACAGAAGCGGCGGTTCCTACCGCGGTGTGCGGCCGGCGCGATATCGGCCTTTTTACTAACCGAACCCGATGTGGGCTCCGATCCGGC




(SEQ ID NO. 162)







GCGCATGGCATCGACGGCGACGCCGATCGATGACGGCCAGGCTTACGAGCTTGAGGGTGTGAAGTTGTGGACCACCAACGGTGTGGTAGCGGACCTGCTAGTGGTT







ATGGCGCGGGTACCGCGCAGTGAAGGGCACCGAGGGGGAATCAGCGCCTTTGTCGTCGAGGCTGATTCGCCCGGGATCACCGTGGAGCGGCGCAACAAGTTCATGG







GACTGCGTGGCATCNAAAACGGCGTGACCCGGCTTCATCGCGTCNGGGTGCCCAAAGACAACTTGATCGGCA






Clone Rv180




:::::::::::::Rv180SP6.seq:::::::::::::







CTCAAGCTTGGCGATGCGGGCTGGCCAAAACTGGCCGGGCGGGGGTTGGCTTGTTCAATCAAGGGTGGGTTGCCG




(SEQ ID NO. 163)







:::::::::::::Rv180T7.seq:::::::::::::







CCGAAGGCCCGTTCCCGGGCGTTCAGCAAGCGATCGTCGGTTGGCCCACTGCGGGTCGAATCTTGCGGCCGCGCCGGTCGTGGAACGCCCAGGTCACCCGGCGGCG




(SEQ ID NO. 164)







TACC






Clone Rv181




:::::::::::::Rv181SP6.seq:::::::::::::







ATACTCAAGCTTTTTTCTGCTCATGAAGGTTAGATGCCTGCTGCTTAAGTAATTCCTCTTTATCTGTAAAGGCTTTTTGAAGTGCATCACCTGACCGGGCAAATAG




(SEQ ID NO. 165)







TTCACCGGGGTGAGAAAAAAGAGCAACAACTGATTTAGGCAATTTGGCGGTGTTGATACAGCGGGTAATAATCTTACGTGAAATATTTTCCGCATCAGCCAGCGCA







GAAATATTTCCAGCAAATTCATTCTGCAATCGGCTTGCATAACGCTGACCACGTTCATAAGCACTTGTTGGGCGATAATCGTTACCCAATCTGGATAATGCAGCCA







TCTGCTCATCATCCAGCTCGCCAACCAGAACACGATAATCACTTTCGGTAAGTGCAGCAGCTTTACGACGGCGACTCCCATCGGCAATTTCTATGACACCAGATAC







TCTTCGACCGAACGCCGGTGTCTGTTGACCA






Clone Rv182




:::::::::::::Rv182SP6.seq:::::::::::::







CTCAAGCTTGGTGCCGACATGGCCGGGCTGGAGCCCGCGTATGGCAAGGTTCCGCTCAATGTGGTTGTGATGCAGCAGGACTACGTTCGCCTCAATCAGCTCAAAC




(SEQ ID NO. 166)







GTCACCCCCGTGGCGTGCTGCGCAGCATGAAGGTCGGCGCCCGCACGATGTGGGCGAAGGCAACAGGTAAAAACCTGGTCGGCATGGGTCGAGCCCTCATTGGGCC







GTTGCGGATCGGGTTGCACCGCGCCGGAGTGCCGGTCGAACTCAACACCGCCTTCACCGATCTTTTCGTCAAAATGGCGTCGTGTCCGGGGTATAC







:::::::::::::Rv182T7.seq:::::::::::::







CCGAAGCGTGGGAAATCCTGACCGAATACCGCGACGTGCTGGACACTTTGGCCGGCGAGCTGCTGGAAAAGGAGACCCTGCACCGACCCGAGCTGGAAAGCATCTT




(SEQ ID NO. 167)







CGCTGACGTCTAAAAGCGGCCGCGGCTCACCATGTTCGACGACTTCGGTGGCCGGATCCCGTCGGACAAACCGCCCATCAAGACACCCGGGGGAGATCGCGATCGA







AACGCGGCGAAACTTGGGCC







:::::::::::::Rv183SP6.seq:::::::::::::







CGACTCGACAAGCATTCTTGACAGTTGTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCGTCCGGGTATGCT




(SEQ ID NO. 168)







GCCGCCGGGATTCTCGCTGCTATTACTCCCCCCGAAAAACGCCACCGGTCCAGCGCGTGGGCCGCCGCGGTCCCCATCACAAACTGAACCCCCAACAGGGGACATG







CTTAGCGGTAGGGCGCGCGCCAAGGCGGCAGCAATCGCATCACTGCGCTGCGCGTCACTATTAACCCACCCGGACTTCACTTCCACGACCCCGAATGGCGCCCGGT







CATTGATCATCTTGCGCACCGCGGATAATCCGGGATTGCCAGCCCATTCGACTACCGCATGCGAGTCATCGGCTGACCGCAGCGGTCCGATTACCCGAGCGCCCCG







ANTACATCTCCTCCAATATCAATGGGCGCAA






Clone Rv183




:::::::::::::Rv183:::::::::::::







GCGGTNTAGCTTCCCGTCGTACCGGCGACCGCCAGCCGAGAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGAGTGCGTGCCAGACCGCTTCC




(SEQ ID NO. 169)







GCTTCGGGTTACAACGAGCCGCGGGGCTACGATCGTGCGACGCTGAAGTTGGTGTTCTCCATGGACTTGGGGATGTGCCTGAACCGGTTCACCTACGACTCCAAGC







TGGCGCCGTCTCGTCCGCAGGTCGTTGCTTGCGATAGCCGGGAGGCCCGGATCCGCAATGACGGATTCCATGCCAACGCTCCGAGTTGCATGCGGATCGACTACGA







ATTGATCACCCAGAACCATCGGGCGTATTACTGCCTGAAGTACCTGGTGCGGGTCGGATACTGCTATCCGGCGGTGACGACCCCCGGCAAGCCGCCATCCGTGCTG







CTGT






Clone Rv184




:::::::::::::Rv184SP6.seq:::::::::::::







CTCAAGCTTGGGCGTGACGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCG




(SEQ ID NO. 170)







CTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCA







ATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAAAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAA







CCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATGGTTATTCC







:::::::::::::Rv184T7.seq:::::::::::::







CGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAGGAGTGCTGAACCGTAGTCGAAGTGGGCGGCGTCAGACTCCA




(SEQ ID NO. 171)







CCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTGGGGCAATGACAGGTGGCGGCGGTGCGTTCGGGTC







GGCCGGCGGAGGTGCTGCGTTGGGATCGCCCGGCTGGGCATTCGGCGTGTTGGCGGCGGCCGGTGGTGGGGGGGCAACANGTGTCGCCGGTGCGGGTGGCGCTGCA






Clone Rv185




:::::::::::::Rv185SP6.seq:::::::::::::







NCTTGATATTGGCGTCAACGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAG




(SEQ ID NO. 172)







CACCACGCCGCGCCCCTCACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAA







TGCACCCGGACCAGCACGTCGTCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTCGTAGATGCTGGTGTAGCCGATGG







CGCGAAACTCCCCATGACGAGTCGGAATCCGCGCCTCGGCGACCCGCTCAATGTGCTTCTCGTGCTTGCGCCGCCATTCGATCAAGTCAGCAATGGTGATCAGCGC







CAGACCGTGCTCNTCGGCG







:::::::::::::Rv185T7.seq:::::::::::::







CATAAGGGCCGGCGTACCCGGTACCGGCCGCGGGCCTACCACGTGCCGGAACTGGAAGCGCAGTAAGCCCTCAACGCGCCACCGCTTTGGCCCGCGCGCCCGGCGT




(SEQ ID NO. 173)







AGGCGCATCGGCGGTGGCCGTGGGGCGGCGCACTGCGACCTCACCAGCGGCTTTCGAGCTTTGTTCGATCAACCGGCCAGCATGGTCGAGGATGCATTCGAGACCA







TATTCGAAATTGGTTTCATCGGGGGCCCCGATCCGATGCCCCCTCCCAGTTGCGTGAGCAAGCAGCGGAGTCGTCGCGGGATCGATGGCCACGGGGTGTTCAATGG







CGGATGGTCCGCTGCCCGCCGACTGGCTCTTGCGGGAGAGCCGATCTAGCACCACCGATCCGCGCACGTGGACCGAAACCGCCGAGTAGATGTCGAAAGCGT






Clone Rv186




:::::::::::::Rv186SP6.seq:::::::::::::







CGTCCTTTTCCCCAAGATAGAAAGGCAGGAGAGTGTCTTCTGCATGAATATGAAGATCTGGTACCCATCCGTGATACATTGAGGCTGTTCCCTGGGGGTCGTTACC




(SEQ ID NO. 174)







TTCCACNAGCAAAACACGTAGCCCCTTCAGAGCCNNATCCTGAGCAANATGAACAGAAACTGAGGTTTTGTAAACGCCACCTTTATGGGCAGCAACCCCGATCACC







GGTGGAAATACGTCTTCAGCACGTCGCAATCGCGTACCAAACACATCACGCATATGATTAATTTGTTCAATTGTATAACCAACACGTTGCTCAACCCGTCCTCGAA







TTTCCATATCCGGGTGCG






Clone Rv187




:::::::::::::Rv187SP6.seq:::::::::::::







CTCAAGCTTCATGTCCGTACGGCTCGGGTACGCTTCCGTCGCAGTGTGCGAGTGATAAATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTC




(SEQ ID NO. 175)







AGTTGCTCACCGGAATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTC







CGCAGGCTTCGTCGGGGTGGTCGCGACACGCATGGGCCCCATCGCATTCAC







:::::::::::::rV187T7.seq:::::::::::::







NCGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGA




(SEQ ID NO. 176)







GCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCGAGGTCGATACCGATTTGCGCATCCGCAGCCGCACCCTGGACGAC







AGAACCGTGCCCTACGANTGCTTGTCGGGCGGGGCCAAAGAACAGCTTGGCATCCTGGCGCGATTGGCCGGCGCGGCGCTGGTCTCCAAAGAAGACGCCCTTCCGG







TGCTGAT






Clone Rv188




:::::::::::::Rv188SP6.seq:::::::::::::







CGCCACGTTCATGGGCAACAACCCCGATCACCGGTGGAAATACGTCTTCAGCACGTCGCAATCGCGTACCAAACACATCACGCATATGATTAATTCGTCCAATTGT




(SEQ ID NO. 177)







ATAACCAACACGTTGCTCAACCCGTCCTCGAATTTCCATATCCGGGTGCGGTAGTCGCCCTGCTTTCTCGGCATCTCTGATAGCCTGAGAAGAAACCCCAACTAAA







TCCGCTCGTTCNCCTATTCTCCAGCGCCGGG






Clone Rv189




:::::::::::::Rv18SP6.seq:::::::::::::







ATACTCAAGCTTCAACCGATTGACGCATTGTGCGAACTGACGGCGCCCGCGCATGGCCAATCCGGAAGACCATCATTGGCCAGTGGCCGGGCGCTAACAGGTTCCA




(SEQ ID NO. 178)







GCCCCCCACCAGTGCCGCTCGAACATGCGGTGCAACCCATTCGCAGGCCGGCAGGGAAAGCACCGCGGAAGCCGCAAAGGGCTGCAGTTCCGCGCCCAATAGTGTC







GTCCGCAACCAGATGCGCTCGAAAACCGCGCCGGCAGTCAGCGCACCCGACGCGAGGTCGAGAGACGTCGTCAGCGCGCCCACATGGGGTGCCAATCGGCACGGCA







GGTAGGCCGCGCGCAACCCGAACGCGTGGTGCATGCCCACGGTCCGCAGGAGGCGCAGCACCCGCCAATGCCGAAGCCCACGAAACATCGGGCGCATCCACGCTTC







AACCTC






Clone Rv18




:::::::::::::Rv18T7.seq:::::::::::::







AGCTTTTGGCAGGGTCTCCTTCGAATTCGGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCGCCGCACACCCCACTGGCCCGGGTGTTTTCGCCCCGAACCCGG




(SEQ ID NO. 179)







ATCATGGTGAGCGAAAAGGAGATTCGCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCGCAGTCCC







GCTCCGTCGACGTCTCCGACGATCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCACAAGGTGATTCTGTCCCGTTG







TGTCGAAGTGCCTTTCGCGATCGACTTTCCGTTGACCTACCGGCTGGGGCGTCGGCACAACACCCCGGTGAGGTCGTTTTTGTTGCAGTTGGGCGGAATCCGTGCT







CTGGGTTACAGCCCGAATCGTCAC






Clone Rv190




:::::::::::::Rv190SP6.seq:::::::::::::







ATACTCAAGCTTTGTCACACCAACTGTTTCCACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCA




(SEQ ID NO. 180)







GCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACTTCTATGGTTGCGGCACGGGTGTCGAAATCACGGTGGC







GGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGTAGCCCGCCGCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGGCGATGAACGTCGAGAG







CAGCCCGCGCAGCAGATCCGGGCTCGCCTGTGCGAGTTGGTCAGCCAGAACCTGCTCGGTGT







:::::::::::::Rv190T7.seq:::::::::::::







CCTTAAGCCCCGCAGGGCCCGGCACGCGCGGTACCGCCCAGGTCGCCCAACAGATCGTCGATGTTCGCGTCGTCCGCCTCGCGCACGTGGTCTGTCACCAGTCAAC




(SEQ ID NO. 181)







GTTAACGCCGCCGCACATGTCCTGCGGCCGGGCAAAAACGTGAAAAACGAGCGGGCGACTGCAATGTCATGACACCGACGGCCGCCGATGGGCCCAGGGTCTGGCA







GATTCGATCTGTGCGGCCAGTGCCAGCAGCGTCGCCTCGTCATACGGCCGGCCGACGAGTTGAACCGACATGGGCAGGCCGTCGCCGTCGAAGTCCCACGGCACCA







CGGCCGCGGGCTGGCCGGTCAGATTCCAGACTTGAAAGTACGGAACCCGCTGCACCACCAGCAGCAACGTCGAAACTGCACCCCGGCGTTGGTAGGCGCCGATGCG







GGACGGGCCGGTCGCGGCGCCTGGCGTCACAACTACGTCGACATCGTCGAAGATCGACTGGATCGGCTGCTCACACCACTCGGCGGCCGCAGGCCGCCATCCGCCG







TC






Clone Rv191




:::::::::::::Rv191SP6.seq:::::::::::::







AGCTTTTTGAGCGTCGCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGCCCACCCTCAT




(SEQ ID NO. 182)







TGGCGATGGCGCCGACGATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTGGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTTGCGGACGGTC







CCGACGCTGGTCGCGGTTGCGCCGCGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGCGGCACTGCACGGCCAGTGCCGCGGCGATGTCAGCCATC







GGGACATCATGCTCGCGTTCATACTCCTCGACCAGTCGGCGGAACAGCTCGATTCCCGGACCGCCCAGCGCATTGGTGATGGAATCGGCGAACTTGGCCACCCGCT







GGGTGTTGACATCCTCGACGGTGGGCAATTGCCCCCGGTAACGTTTGCCGCCT







:::::::::::::Rv191T7.seq:::::::::::::







CGGTCCGACCCTGTTCGACGGCTACCTGAATCAACCCGATGCCACCGCCGCGGCGTTCGACGCCGACAGCTGGTACCGCACCGGCGACGTCGCGGTGGTCGACGGC




(SEQ ID NO. 183)







AGTGGGATGCACCGCATCGTGGGACGCGAGTCGGTCGACTTGATCAAGTCGGGTGGATACCGGGTCGGCGCCGGTGAAATTGAAACGGTGCTGCTCGGGCATCCGG







ACGTGGCGGAGGCGGCAGTCGTCGGGGTGCCCGACGATGATCTAGGCCAGCGGATCGTTGCCTACGTAGTCGGCTCAGCGAATGTCGATGCGGACGGGCTTATCAA







CTTTGTTGCCCAACAACTTTCGGTGCACAAGCGCCCGCGCGAGGTGCGTATCGTANATGCGCTGCCGCGCAACGCCTTGGGGAAAGTGCTCCAGAACATTGCTGTC







AGAAGCTGANCTACGCGAATTATCGTGTTACGCTGGA






Clone Rv192




:::::::::::::Rv192SP6.seq:::::::::::::







ATACTCAAGCTTGCCGAAGTTCCGATGGGTCGCGCCGGCGAGCCCAGCGAAGTCGCTACCGTGGCCGTGTTCTTGGCTTCGGATCTATCCTCGTTCATGACCGGCA




(SEQ ID NO. 184)







CCGTGTTGGACGTGACTGGCGGCCGGTCCATATGACACCGAGATCATTGCCACGGTACGGCAATTCGTCAAGAAGGAAATCTTTGGGAATGCACCGGCCCTCGAAC







GTGGCAACAGCTACCCGCAAGAAATCGTCGATCGGCTGGGTGTTATTGGCTTGCTCGGTCGCCGGCTGCAAGGGTATCGACACCACCGAGTTCATTCTCGGGCGTG







CCGGCGCATTCGAGCTGGCGGTGCGCGCTGCCCAGCACCGTCATAGGTACTTGACGATGGTCCACGTCGGACGAGCGCCTCCACGTCGCTGCCGAACGGTATGCAT







GGCGGCTACGATTCTC







:::::::::::::Rv192T7.seq:::::::::::::







CGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAGCACCACGCCGCGCCCCTC




(SEQ ID NO. 185)







ACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAATGCACCCGGACCAGCACG







TCGTCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTCGTAGATGCTGGTGTAGCCGATGGCGCGAAACTCCCCATGAC







GAGTCGGAATCCGCGCCTCGGCGACCCGCTCAATGTGCTTCTCGTGCTTGCGCCGCCATTCGATCAAGTCAGCAATGGTGATCAGCGCCAGACCGTGCTCATCGGC







GAACACCGCAATTCATCGGTGTTGCGCCATCGAGCCCTCATCTTTTTGGCTGACGATCTCGCAAATCGCCCCCGCGGGTTGCAGCCGGCAT






Clone Rv193




:::::::::::::Rv193SP6.seq:::::::::::::







ATACTCAAGCTTTGGGTGAAAGCCGATCACCGGAAGCCGCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGC




(SEQ ID NO. 186)







GGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGT







CAATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTNCTCGCCCGGTGCGCTCGGCCGATAAGTTGCACCGCCACCACCGCGACACCGTCTTGCACGCG







GACCCACCCCCGGATCCGTTGTTGGCC







:::::::::::::Rv193T7.seq:::::::::::::







AGCTTGCTGGCATCCGCTCCAGTAGCGCCCCGCGCGTGGCTTCCAGCGCCCGCAGATGCTCCATGAGCCGGCCGGTCGAGTCGGCGCCGGCGTTCACCGCCACCCG




(SEQ ID NO. 187)







CCAGGAGCTGGCGGCCAGCATCTCCGCCTTCACGCATTGCGCGATCACAGAGAGAATATACGTCTCATATTCGTTGGAGGTCGTCGCAGGCAATCGGTCGATGACG







GATTTGATGGCATCGAGCTGTGCTTCGGCGTAGCCCTCCAGCACGTCGGTATCGCTGTGGCGGTCCACGACGACCGCACCGGCGCGGCGGACAGCCGTCGGGTTGG







ACGNTGTGCGGCGATCAGTCCGGCCAGCTCCGCCTCGGGATCAGCGGC






Clone Rv194




:::::::::::::Rv194SP6.seq:::::::::::::







ATACTCAAGCTTGCTGCAGCTTCCTATGACTGCTCCCGAAACCTGGGGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGAGACCCGCGGTCGA




(SEQ ID NO. 188)







ACCAGCCACGTGTCCATCATCAGGGGTCAACCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGACCAA







AACAGCTGGTCGGCCGTTAGGAACTGAATTGAAACTCAACCGATTTGGTGCCGCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTGTCCGCGTGTGGTAACNAC







NACAATGTGACCGGGGGAGGTGCAACCACTGGCCAGGCGTCGGCGAAGGTCGATTGCGGGGGGAAGAAGAACTCAAAGCCAGTGGGTCGACGCGCAGGCCAACGC







:::::::::::::Rv194T7.seq:::::::::::::







AGCTTGACGCGGAGACGGACACATTGCGAACATTGATGACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTCCAAT




(SEQ ID NO. 189)







CAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGCGAAA







AACGGTCGCCGTTGCACGACATTAAATGTCACGGTATTGTAGATTAAAAAGATACCCACCAACAAGGCAATCAAACTGAGAGCGGTTAAATTGACCGTAAAAGCGT







CCGTCATCTGTTTGACGGTGTCCCGTTGGGTATCCGACGTTTCCATACGCACACCGGCCGGCAGTCTTTGTTGGATGCGTGTTGCAGTGGCCTCATCTTTGATGAT







CAAATCGATGTGGCTCAGTCTTCCGGGCA






Clone Rv195




:::::::::::::Rv195SP6.seq:::::::::::::







ATACTCAAGCTTCGGCTCAGGCGGCGCTGCTGGTAAAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGC




(SEQ ID NO. 190)







GCAGGCTATCGCACCCGTTATCGGCTACGAGCAAATCGCGGTATCGCTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAG







ATCGCCGTCAAGCATGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCCGCT







CGGATAGCGAGGTCAGCGAATTCNCNTGGCAGCTCCAAAGGGTCCTGCCGGTGCCGGTCTTTGCGCAAACNAAGGCNCAGGTTA







:::::::::::::Rv195T7.seq:::::::::::::







TGATCGCGCATCACCTGCTTCATAAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCA




(SEQ ID NO. 191)







GCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCG







CGTTCTCCACCGACCGGGCCCGGGTGTGGGGTGTTTCGGCGACCGGCAGCCAGGTGGTCCACACTGCCGACGGGCGCCGCGAGCCGTTCACCGACCAGGCCGCCGA







GCAAGTCCGCCCGATCGCATACTCCAACCGGTTGCGGTACTGCAGGTTCAGCTGGCGTACTCCTCGTCGCGCTCGGCGAGGTCTTGCTCCAGCACGTCGCANACGG







CAG






Clone Rv196




:::::::::::::Rv196SP6.seq:::::::::::::







CAAAGCGCGAACTGCTCGCGGCAGCCCACGACGTGCTGCGTCGGATTGCCGGCGGCGAAATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCCGCAA




(SEQ ID NO. 192)







CGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAGCCCGGCAGT







TGCCAAACCCAGCGTGATCAGGCTCGGCTCGCGAGTTCCGGGAAGAAGTGGCTCCGCCTGATCACCTACCATCCGCCAGGATCTGCGTGTCTTCACCACGCCCGCC







AAGGAGGTTGTTGTGGTGCTATCGACCGN







:::::::::::::Rv196T7.seq:::::::::::::







CCGGAAGCCGCATGATCAGCCAAGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCGCCGACGGTGCCGGTTCGCGA




(SEQ ID NO. 193)







GCCGAAGGTGACGACGCTGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGTTGTCGCTTTCTACGGTCACC







GACCCGGTGACCGTNGTCGCCCGGTGCGCTCGGCCGAAAANTTGCACCGCCACCACCGCGAAACCGTCTTGCACNCCGGAAGCCACCCCCGATCCGTTGTTGGGCC







AGGTTATTGGGT






Clone Rv19




:::::::::::::Rv19SP6.seq:::::::::::::







CCGGAACCGCCGACGGCACGGTATAACGCCTCCGCATATGGGTCGACAACCAGCGGGTCGGACTTCTGGGCTTCTAGCGTTCGCGCNGTCGCGACAAACAGCGCGG




(SEQ ID NO. 194)







TCGAACCGACACTCGTTGTGATGTCCTAGCTATCACGTTCGGTACGCACCCAATCGAGTCTAGCGCGGGTAGNTCAGCCCCGATCTCCANGCTCCGCCGAGCCAGG







CGC







:::::::::::::Rv19T7.seq:::::::::::::







CTGGTTTATGTCCCGTTGAAGTTCCATCACCCGATGTGGCGGGAGCACTGCCAGGTCGATCTCAACTACCACATCCGGCCGTGGCGGTTGCGCGCCCCGGGGGGTC




(SEQ ID NO. 195)







GGCGCGAACTCGACGAGGCGGTCGGAGAAATCGCCAGCACCCCGCTGAACCGCGACCACCCGCTGTGGGAGATGTACTTCGTTGAGGGGCTTGCCAACCACCGGAT







CGCGGTGGTTGCC






Clone Rv1




:::::::::::::Rv1SP6D2.seq:::::::::::::







CCGAGCAGTTGGGAATCGCTCTGCANCAAACCAATATTCTGCGCGACGTCGCGCGACGAGCTGGACCGATTAGGCGTACGCCTCCGNCTGGACGACACCGGGGCAC




(SEQ ID NO. 196)







TCGATGACCCCGACGCCTACGCTCGCAGGATATTGTTCGCCGGACCCCTCTCTAG







:::::::::::::Rv1T7.seq:::::::::::::







TATATAATACTCAAGCTTGCCGACGCCAACGCTCGCGCGATGTTGTTAGCCCGACCCGGCTCTTACATGGCACCGGTGCCCCACACGTCAGCCTGTGACGTCCTGC




(SEQ ID NO. 197)







ACCGCGACTCTTTACATAGAATGTGGATTGCCGGATTGGGGATGTCCGGCATCGCTCAATCTGTAGTCCGCGTTGTCCCGCGAGGGCCATGTGGATGGGGGGAAGG







ATCCGTGGCGTCCGGGATCACCATGGGG






Clone Rv201




:::::::::::::Rv201SP6.seq:::::::::::::







ATACTCAAGCTTGCCGAAGTTCCGATGGGTCGCGCCGGCGAGCCCAACGAAATCGCTAGCGTGGCCGTGTTCTTGGCTTCGGATCTATCCTCGTACATGACCGGCA




(SEQ ID NO. 198)







CCGTGTTGGACGTGACTGGCGGCCGGTTCATATGACACCGAGATCATTGCCACGGTACGGAAATTCGTCCAGAAGGAAATCTTTCCCAATGCACCGGCCCTCGAAC







GTGGCAACAGCTACCCGCAAGAAATCGTCAATCGGCTGGGTGTTATTGGCTTGCTCGGTCGCCGGCTGCGAGGGTTTCTACACCACCGAGTTCATTCTCGGGCGTG







CCGGCGCATTCGAACTGGCGGTGCGCGCTG







:::::::::::::Rv201T7.seq:::::::::::::







GCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCATGTACAGCACCACGCCGCGCCCCTCACGGGCGA




(SEQ ID NO. 199)







CCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCACTCCGAATGCACCCGGACCAGCACGTCTTCACC







GTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAACGCGACATGTTCCACGTCCTCGTAGATGCTGGTGTAGCCGATGGCGCGAAACTCCCCANGACAAGTCGGA







ATCCGCGCCTCGGCGAACCGCTCAATGTGCCTCTCGTGCTTGCGCCGCCATTC






Clone Rv204




:::::::::::::Rv204SP6.seq:::::::::::::







TGGTCCGTGTGCGCATACCAATACAACGCGCCGGGCACCTGACGCGGCGGCCGCAACCAATCGGTGGCCATCGCCATCTTCTGCTACCCGGTCAACGGACGCACCT




(SEQ ID NO. 200)







TCTCCTGGCCGACGTAGTGCGCCCACCCGCCGCCGTTGCGTCCCATCGATCCGGTCAAC






Clone Rv205




:::::::::::::Rv205SP6.seq:::::::::::::







GGCGTGTTGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTG




(SEQ ID NO. 201)







TGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGG







TCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAAAGCCACTGGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCA







ACCAAACTTGAAGGTGATTGTTTACCTGGGCTACGGCGACCCGGCCTATGGTTATTCGACCTCCCCGCCCAA







:::::::::::::Rv205T7.seq:::::::::::::







CGTCCGTGNCCCCTCAANCGCGTGNNGCCGAAGCGGCTGGTTACGACTCCCTGTTTGTGATGGACACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCG




(SEQ ID NO. 202)







ATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGANCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGACCCTGCTGG







CAAAGATCATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAAACACCGCCAGCTCGGCTTCGAGTTCG







GCACTTTCAGTGACCGGTTCAACCGGCTCGAAGAGGCGCTACAGATCCTCCAGCCAATGGTCAAGGGTGAGCGCCCAACGTTTTTCGGCGATTGGTACACCACCGA







ATC






Clone Rv207




:::::::::::::Rv207SP6.seq:::::::::::::







CCGCTTCCGTGTAACCGAGCANNGCGAGCGANCTGGCGAGGAAGCAAAGAAGAACTGTTCTGTCAGATAGCTCTTACGCTCAGCGCAAGAAGAAATATCCACCGTG




(SEQ ID NO. 203)







GGAAAAACTCCAGGTAGAGGTACACACGCGGATAGCCAATTCAGAGTAATAAACTGTGATAATCAACCCTCATCAATGATGACGAACTATCCCCCGATATCAGGTC







ACATGACGAAGGGAAAGAGAAGGAAATCAACTGTGACAAACTGCCCTCAAATTTGGCTTCCTTAAAAATTACAGTTCAAAAAGTATGAGAAAATCCATGCAGGCTG







AAGGAAACAGCAAAACTGTGACAAATTACCCTCAGTAGGTCAGAACAAATGTGACGAACCNCCCTCAAATCTGTGACAGATAACCCTCAGACTATCCTGTCGTCAT







GGAAGTGATATCGCGGAAGGAAAATACGATNTGAGTCGTCTGGCGGCCTTTCTTTTTCTCAATGTATGAGAGCG






Clone Rv209




:::::::::::::Rv209SP6.seq:::::::::::::







TGACACCCAACAGAGGGCACTTAAGATGGCAATGCGGCCGCCTACCTGCACGTTTTCGCGATGTCAGAGGATGCCGAGGGAGAACAATGCGAGCACGGCCGCTGAC




(SEQ ID NO. 204)







NTTGCTCACCGCTTTGGCGGCGGTGACATTGGTGGTGGTTGCGGGCTGCNAGGCCCGANTCNAGGCCGAAGCATATAGCGCGGCCGACCGCATTTCGTCTCGACCG







CAAGCGCGACCTCAGCCGCAGCCGGTGGAGCTACTGCTGCGCGCCATCACGCC







:::::::::::::Rv209T7.seq:::::::::::::







ACGGGCGACGCTGAGGTGGGCCCGCGGCTATTCATGCTGTCGTCCACGTCCAGCGACGCACTGCGCCAGACGGCCCGCCAACTAGCCACCTGGGTGGAAGAACACC




(SEQ ID NO. 205)







AGGACTGCGTGGCGGCCTCGGATCTGGCCTACACGCTGGCGCGTGGCCGCGCGCACCGGCCGGTGCGCACCGCGGTGGTTGCCGCCAACCTGCCGGAGCTCGTCGA







GGGTTTGCGCGAGGTGGCCGACGGTGACCCCTCTATGACGCGGCGGTGGGACACTGTGATCTAAGACCGGTCTGGGTCTTCTCCGGGCAAGGGTCTCAGTGGGCGG







CGATGGGCACCCAATTGCTCGCCAGCGAACCAGTGTTCGCGGCCACCATCG






Clone Rv20




:::::::::::::Rv20SP6.seq:::::::::::::







ATACTCAAGCTTCGCGAGATCCGGATGGCACTCACGCTGGACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACT




(SEQ ID NO. 206)







CGTTCGGCGTGCAGGACGCGGCGCAAACGTACTTCGGCATCAACGCGTCCGACCTGAATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCGACCAGCAC







GCTCAACCCGTACACCAACCCCGACGGCGCGCTGGCCCGGCGGAACGTGGTCCTCGACACCATGATCNAAAACTTCCCGGGGAGGCGGAGGCGTTGCGTGCCGCCC







AGGGCGAACCGCTGGGGGTTCTGCCGCAGCCCAATGATTGCCGCGCGGCTGCATCGCGGGCGGCGACCGCCATTCTTCTGCGAATACGTCCAGGAGTACTGTCTCG







GGGC







:::::::::::::Rv20T7.seq:::::::::::::







AGCTTATGTGGCCGCCCACCTACCTTATCTAGCCTAGCTAACTAAATCCAGTGCCGACAGTGCGCGGCTGGCCACCCAGCATGAGGTTATGACCACGGCATATGCC




(SEQ ID NO. 207)







AGCGCGCTGGCGGCGATGCCGACGCTGACCGAGTTGGCCGCTAATCACACCAGCCATGCGGTGTTGCTGGGAACGAATTTCTTTGGAATCAATACGATCCCGATCG







CGCTCAATGAGGCCGACTATGCGCGGATGTGGATTCAGGCGGCCACCACGATGAGTATCTATGAGGGCACCTCCGATGCGGCGCTGGCGTCNGCACCGCAAACCAC







ACCGGCTCCGGTACTGTTCAACGGCGGTGCTGGCGTTTGCCAGCGCCTGCCGGCGATCTC






Clone Rv214




:::::::::::::Rv214SP6.seq:::::::::::::







ATACTCAAGCTTGCCACCCATGCCGAGCAAGGTCGACTCAGCGATGACGAATTGTTCTTCTTCGCGGTGTTGCTGCTGGTTGCGGGCTATGAGAGCACTGCTCATA




(SEQ ID NO. 208)







TGATTAGCACNTTGTTTCTGACGCTGGCCGACTATCCAGATCAGCTGACACTCCTTGCGCAGCAACCAGACCTGATCCCGTCGGCGATCGAGGAGCACCTCCGCTT







TATATCGCAATCCAAAACATCTGCCGCACAACGCGCGTCGACTATTCGGTCGGTCAAGCGGTCATCCCGGGA







:::::::::::::Rv214T7.seq:::::::::::::







CCGGGGTAGAACGATGCGATCTGGGCCATGTCGACATCGGTGGTACAGGTAAACCGCGCCGTGTGCGCGGTCTCGGAGATCAGAACGTGGTCGCAGTTGACACCGC




(SEQ ID NO. 209)







GGGCTTTCAGCCAGTCGCGATAATCGGCGAAGTCGGCGCCTGCCGCCCCAACTAGCGCGACCTCGCCACCTAGCACACCGATGGCGAAGGCCATGTTTCCGGCCAC







GCCGCCGCGGTGCATCATCAACTC






Clone Rv215




:::::::::::::Rv215SP6.seq:::::::::::::







ATACTCAAGCTTGGCGGCAACGCCACTACCGGGCTCACCAGGTCCTGTGCCGCCACCGCCGGCGCCGAAAGCACCATCAGGTCGTAGTTGTCTGGACGTTCGACAC




(SEQ ID NO. 210)







CGTAAGCGAACACAATGCCGCCGCCCATGCTGTGCCCGAGCACGATGCGCTTGCACCCGGGATATTCCCGGGTGGCGATCCCAACGAGGGTGTCGAAGTCAGCGGT







GTATCTGAGATGTCTCTCACTATCATCCGTTTGGCACCCGAGCGGGCATGCCCGCGGGGGGTCAAC







:::::::::::::Rv215T7.seq:::::::::::::







GTCGACGGCATCAAGGTCCGCAGTGATGGTGTTCATCTCACCCAGGAAGGCGTGAAGTGGCTGATACCGTGGCTTGAGGATTCGGTGCGGGTCGCCAGTTAATCCG




(SEQ ID NO. 211)







CCGTGTGCTCCGGATGAGCGCGACGGTAACCCTGGAATTGTGCTGTGTGCTGGCTGTGTCGTTGTGATGAGCCTGTCTAAGTGGTGCGTAACCGTTTGACGAGCCG







CGGCCTCGCTGCAAACATTGAAGCCCGCACGTCTGGGTTTGTATTTACACAACGAGGGCGCTCCCCGATCTGGCGCGCGCAACGAGGTGCNCACTATCCATTCGAG







GTGAACTGGACTCCTTGATGCTCATGCCGGTGCGGTTTTGTC






Clone Rv217




:::::::::::::Rv217SP6.seq:::::::::::::







ATACTCAAGCTTGCGTTCGATGAAGTAGTCGTCGGTCAGCGCCGCCTCTTCGAGCTCCTTGGCGATGCCCAGCAAGGAGTCATCGCCGCCGAGCTTGGCCAGGATC




(SEQ ID NO. 212)







TTGTCGGCCTGTTCCTTGACGATGCGGGCCCGCGGATCGTAGTTCTTGTAGACACGATGACCGAAACCCATCAATTTGACCCCGGCCTCGCGGTTCTTGACCTTGC







GTTACAAACTCGCTGACGTCGTCGCCGCTGTCGCGAATGCCCTC







:::::::::::::Rv217T7.seq:::::::::::::







NGTCAAGCCGAGCATGCGCGAGGNAACGACGAACCCAACAAGCCATGGTGGTTGGCGCCGTCGAGAGGTCGGCGGTCGCCACAACGGGAAGATCGCCTTGAGCGTC




(SEQ ID NO. 213)







GCTCGACCGCCGCCTCGAGTTGGGTCATAACGAAGTAGCTGATGCCGATCATGTCGACGTTTCCGTCGCATCAGCGTGCAGCGGCGACCCACTCGACGAGGTCTCG







GTGCCGCCGCGGCCAGGGCACCAGCAGTGACGATTCCAGGCGCCGTCGGG






Clone Rv218




:::::::::::::Rv218SP6.seq:::::::::::::







CGATAATCGCTTCCGGTAAGTGCAGCAGCTTTACGACGGCGACTCCCATCGGCAATTTCTATGACACCAGATACTCTTCGACCGAACGCCGGTGTCTGTTGACCAG




(SEQ ID NO. 214)







TCAGTAGAAAAGAAGGGATGAGATCTCCCCGTGCGTCCTCAGTAAGCAGCTCCTGGTCGCGTTCATTACCTGACCATACCCGAGAGGTCTTCTCAACACTATCACC







CCGGAGCACTTCTAGAGTAAACTTCCCATCCCGACCACATATAGGCTAAGGTAATGGGCATTACCGCGAGCCATTACTCCTACGCGCGCAATTAACGAATCCACCA







TCGGGGCCGCTGGTGTCN






Clone Rv219




:::::::::::::Rv219SP6.seq:::::::::::::







NAATACTCAAGCTTTCTCGTGATTACCACCCGTGTAATTTGGGATGGGCAAAAAGGCGAATCACCGCGTGGCCACAAACGCCGGGAGGGACAATCTCGGGCGGCTA




(SEQ ID NO. 215)







GGGCTTCTCGCGGGAAGGCCCGAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTAGGGGATGGCAGCAACCTGGTATCACCCTGGCCGGG







CAATGATCTGCAGCGTCGCCGCGGGTAGTGNCCGCCCGGGCGGCTAC







:::::::::::::Rv219T7.seq:::::::::::::







CCAACTAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGC




(SEQ ID NO. 216)







CAGCGCGTGCCGGGCCACGATGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCGACATCGTCACCGCCGCACCACTGCCCGGTCTCGGGTTCACGCAG







CCGTTGCCGCCCGCAGCGGACGATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGGCCGCGCTGGCGGGCTGATGATCGCCCTGACCCCTCAATTCGGG







TCCAAGA






Clone Rv21




:::::::::::::Rv21SP6.seq:::::::::::::







ATACTCAAGCTTGCTGCAGCTTCCTGTGACTGCTCCCGAAACCTGGGGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGAGACCCGCGGTCGA




(SEQ ID NO. 217)







ACCAGCCACGTGTCCATCATCAGGGGTCAACCCCGGCCAAGGGCGACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGAGCAA







AACAGCTGGTCGGCCGTTAGGAACTGAATTGAAACTCAACCGATTTGGTGCCGCCCGTAAGTGTCCTGGCTGCCGGTGCGCTGGTGTT







:::::::::::::Rv21T7.seq:::::::::::::







AGCTTGCGCGGCGTGGCGATCGCGGTTCAAGGCGCGCTCTTCGAGCACAACGAGCGAAGACAGCTCGGCGACGGAGCCTTTATCGACATCCGTTCGGGCTGGCTGA




(SEQ ID NO. 218)







CCGGCGGCGAAGAACTGCTGGACGCGTTGTTGTCGACGGTGCCGTGGCGAGCCGAGCGCCGTCAGATGTACGACCGGGTGGTCGATGTGCCGCGGCTGGTGAGTTT







TCACGACCTGACCATCGAAGATCCGCCGCATCCGCAGCTGGCGCGGATGCGCC






Clone Rv220




:::::::::::::Rv220SP6.seq:::::::::::::







AATACTCAAGCTTGCGCACGACCAGGACGTCGAGTGGCGCTTGCAGTGACTTGGCGACCTCAAAGGCCACCGGTACCCCGCCGCGCGGCAAGCCAAGGACNACNAC




(SEQ ID NO. 219)







GGCCTTGCCGGATAGCTGCGCCAGGCGTTGCGCCAACTGGCGTCCAGCGTCGCCACGATCGTCAAAGAGCTTCATCTGCCGAGTGTGTCGCCATCTCATGGCTCCA







AATATGGAATTAGGTCCCTGGGCCGACTGACGACAGTCCCTCAGCGACCGGATTGCGCATCCCGCCTTGTACGCTGCTCCGCAAATCCCGGGCTTGCGTCCGCGGA







AGCGAACTCGGCGGCGCTACGGTGGTGGCTCACTTCGGCCGTGC







:::::::::::::Rv220T7.seq:::::::::::::







GGTTGGTGCGGTCCACCTTCGCGGCGGCGGCGCGATATGCCTTGCTGGTCTTGCTCATTTGATATCCAATCTATGGGTCGTGGTTACTCAGCGGGCCGAAGCTGGC




(SEQ ID NO. 220)







CCTCCCACGGGTAGGGCCCTATTCGACGGTGATGCCCATCGACCGAGCGGTACCGGCGATGATCTTGGCCGCAGCGTCGACGTCGTTGGCGTTGAGGTCCGTCTTC







TTGGTCTCGGCGATTTCGCGGACTTGATCCCAGGTGACTTTGGCGACCTTGGTCTTGTGCGGCTCCGCCGAACCCTTCGCCACACCAGCGGCCTTAAGCAGCAGCT







TGGCGGCGGGCGGCGTCTTCAGCGTGAAAGTGAAGCTACGGTCTTCATAAACGGTGATCTCCACCGGGATGACGTTGCCGCGCTGGTTCTCCGTCGCGGCGTTGTA







CGCCTTGCAGAACTCCATGATGTTGACCCGTGCTGACCGAACGCGGGGCCCACTGGCGGGGC






Clone Rv221




:::::::::::::Rv221SP.seq:::::::::::::







ATACTCAAGCTTTTCGACCCGCAAGCCGGCGGTGCCCCTCCTCGTTCCGCTGCCCGGTCTGCTCGATCGGTTCGGGGTCGCCGCGCTAGGCCCAATTGCCCGGCTC




(SEQ ID NO. 221)







CTCCTCGGGCCGTTCCACAACCCGCATCGTCGCCGGGCTAGGTTCAAGCCATGCCGGTAAACCCCAGGACGCCAGTGCTGATCGGCTATGGACAGGTCAACCACCG







AGGCGACATCGACGCCNAAAATCAGTCCATCGAACCCGTCGACCTGATGGCCNCCGCGGCCCGGAAAGCCGCCGAGTCCACCGTGCTCGAAGCGGTGGATTCCATC







CGTGTGGTGCACATGCTGTCGGCGCATTACCGGAATTCCCGGGCGTCTCCTCGGC







:::::::::::::Rv221T7.seq:::::::::::::







NCCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGCCGCGA




(SEQ ID NO. 222)







CAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCCACCG







ACCGGGGCCGGGTGTTGGGGTGTTCGGCAACGGCAACCAAGTTGGTCCACACTGCCGACGGGCGCCGCAAATCCGTTCACCGAACCAGGCCGCCNAAACAATTCCG







CCCGATCCCATAT






Clone Rv222




:::::::::::::Rv222SP6.seq:::::::::::::







ATACTCAAGCTTGTCGGGATCAATCTCGAGGGCATCCACGCACGAAAAGTAAACTCTATCAAGCTTTTTGACGACACCCACGGACGCCCCATATATGTTCGGGTGG




(SEQ ID NO. 223)







GCAAGAACGGTCCCTACCTGGAACGTTTGGTGGCCGGCGACACCGGTGAGCCCACGCCGCAGCGGGCCAACCTCAGCGACTCGATTACCCCGGACGAACTGACTCT







ACAGGTGGCCGAAGAGCTCTTTGCCACACCGCAACAGGGACGGACTTTGGGCTTGGACCCAGAAACCGGCCACGAAATCTTTGCCAGGGGAAGGCCGGTTTGGGCC







TTATGTTACCTATATCCTGCCGGAACCTGCGGCTGATGCGGCCGCGGCCGCTCAGGGAN







:::::::::::::Rv222T7.seq:::::::::::::







AGCAGCTAGCCGCGCTCGCCGCGCTGGTCGGTGCGTGCATGCTCGCAGCCGGATGCACCAACGTGGTCGACGGGACCGCCGTGGCTGCCGACAAATCCGGACCACT




(SEQ ID NO. 224)







GCATCAGGATCCGATACCGGTTTCAGCGCTTGAAGGGCTGCTTCTCGACTTGAGCCAGATCAATGCCGCGCTGGGTGCGACATCGATGAAGGTGTGGTTCAACGCC







AAGGCAATGTGGGACTGGAGCAAGAGCGTGGCCGACAAGAATTGCCTGGGCTATCGACGGTCCAGCACAGGAAAAGGTCTATGCCGGCACCGGGTGGACCGCTATG







CGCGGCCAACGGCTGGATGACAGCATCGATGACTCCAAGAAACGCGACCACTACGCCATTCAAGCGGTCGTCGGCTTCCCGACCGCACATGATGCCGAAGAATTCT







ACAGCTCCTCCG






Clone Rv223




:::::::::::::Rv223IS1081N1400.seq:::::::::::::







CGCGACTGGCTCCCCGGNCGGCTGCTCGGGTCCGCCGATAGAGACCGGGATGTCGCCCGACGACGGGCAGCCGGGTTGCGTGGGACGGGGCGGGGGTCGGGCAGCC




(SEQ ID NO. 225)







CAAGCAACGGGCTAGTCCCCGAATCCTACGGAGCCGTCACCTACGCCTACGTAATAGTAGCTATCAATAACAGTTGACATACGCAACGATCTGTGAGATCAATATT







GCCTGACGCATGTCAAGACAGGCGTCAAGACAGGTGTCAATAATTCGCTCCGCTGGTGACGGTAACCGGTCGTGCGGGTGTGTGACGCCTAAGGAAGGAGTGTGGG







TGGTGACGCTGAGAGTGGTTCCTGAGGGTTTGGCGGCCGCCAGTGCGGCGGTGGAGGCGTTGACCGCACGGCTGGCCGCCGCACACGCTGGCGCGGCGCCGGCGAT







TACGGCGGTGGTGGCGCCCGCGGCGGATCCGGTGTCGTTGCAGAATGCGGTGGGGTTTAGCGCCTTAAGTAGCCAGCATGCCGCGATCGCCGGCGAAAGGGTCCAA







GAACTGGGT







:::::::::::::Rv223SP6.seq:::::::::::::







ATACTCAAGCTTATTGAACCGCGGGTCGCAGGCAAAGTGGACCTCATAACGACTCGGGTCCAGCGACCGCGCCAACACGAACGGCCGGACGACGTGGGCCAGGGTC




(SEQ ID NO. 226)







GCGGCCTCCCCTACAAACAGGATCCGTTGCCTGCGAACGACAGGCTCCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGC







TTGTTTCCTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTACCCGCAGGCAACCTCCCAAAAATGCAATCCCGCAAAATGCAATGCGTCNAGCTATTTCTCACA







CCGACCGCTAGTTGCGGATCAGAAATCCGTTGGGCGCGGAAGTCCAGCCGAATTTGTTCTCCCGCTCCGCATCATGCTTGTAATCGTTTGGAAATTCATCCTCATA







TGCCTCGATCGCTTCATAGGGTCCAGGCCCAAACCCGGGCAGGACTGGGTGGCCGTTGATGTTGGAATCCTCCACTACTAGGTATTCACCGGC







:::::::::::::Rv223T7.seq:::::::::::::







GTCTCGATCATGGCCAAAGAGCTCGACGAAGCCGTAGAGGCGTTTCGGACCCGCCCGCTCGATGCCGGCCCGTATACCTTCCTCGCCGCCGACGCCCTGGTGCTCA




(SEQ ID NO. 227)







AGGTGCGCGAGGCAGGCCGCGTCGTCGGGGTGCACACCTTGATCGCCACCGGCGTCAACGCCGAGGGCTACCGAGAGATCCTGGGCATCCAGGTCACCTCCGCCGA







GGACGGGGCCGGCTGGCTGGCGTTCTTCCGCGACCTGGTCGCCCGCGGCCTGTCCGGGGTCGCGCTGGTCACCGGCGACGCCCACGCCGGCCTGGTGGCCGCGATC







GGCGCCACCCTGCCCGCAGCGGCCTGGCAGCGCTGCAGAACCCACTACGCAGCCAATCTGATGGACGCCACCCCGAAGCCCTCCTGGCCGTGGGTGCGCACCCTGC







TGCACTCCATCTACGACCAGCCCGACGCCGAATCAGTTGTTGCCAATATGATCGGGTTCTCGAC






Clone Rv224




:::::::::::::Rv224SP6.seq:::::::::::::







ATACTCAAGCTTTCGTCAGTTCATGGCGCCAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGG




(SEQ ID NO. 228)







CGCGAACGACGCCAGCGACCACATTCAGCAAATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCAAGATCTTC







ACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCATCCGTTTGGCCGCCGCC







:::::::::::::Rv224T7.seq:::::::::::::







GCCCCGTGTAATTTGGGATGGGCAAAAAGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGT




(SEQ ID NO. 229)







ACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTA







GTCTCCGCCCGGGCCGC






Clone Rv225




:::::::::::::Rv225SP6.seq:::::::::::::







ATACTCAAGCTTCCTTTGACCGAACGCGTCCACCGCACCGTGAGATTGGTGGCGCCATTCGTCGTGGTGTAGCTGCTGTTGGCGGCGTCGCCGTATTGTGCGGGCC




(SEQ ID NO. 230)







AGCCTTGTGCGGGGGCCGCTTCTACCCACAAGTCGGCACTTCCGCAACCGCCCAGCTCGACCGCGAATTACGGCGGCCGCAACGGCCGCCGGAAGGCGTCACGCAA







TCGCTTATCCTTTCCAGGTTCCCAAATCCTCCGCTTACTTGGGTCCTTCATCGG







:::::::::::::Rv225T7.seq:::::::::::::







GGCAGCGGCGACAACCGGAACGTCCGCACGGTGCTCAATCACGGGTGCACGGTGTGCATCAGAATGGCGGGGGTTCGTTGTCGCGGTGAGGCGTTCGGCGAGGAGG




(SEQ ID NO. 231)







TAGTGTCTACCCCTTGCCCGCGGGTTCGTGCGGACTGAAAGGGATTTCATTGGGAACCCACGGCTGCGTATCGCAGGGCCTCGGTGACGTCTGCTTCCTCNAGCTC







AGGAAGTTCGGCGAGAATCTCGGTGGATGTTATTTGGTCCGCCTAC






Clone Rv226




:::::::::::::Rv226SP6.seq:::::::::::::







ATACTCAAGCTTTCTCGGCTTCTCTGATAGCCTGAGAAGAAACCCCAAGTTAATCCGCTGCTTCACCTATTCTCCAGCGCCGGGTTATTTTCCTCGCTTCCGGGCT




(SEQ ID NO. 232)







GTCATCATTAAACTGTGCAATGGCGATAGCCTTCGTCATTTCATGACCAGCGTTTATGCACTGGTTAAGTGTTTCCATGAGTTTCATTCTGAACATCCTTTATTCA







TTGTTTTGCGTT






Clone Rv227




:::::::::::::Rv227SP6.seq:::::::::::::







ATACTCAAGCTTGGTGACCGGCACCGCGATACGTTGCGGCAGGCATCTGGGCTGGCGGTGGTTCGCCGCTCCGAAGCCGTCGAACACCATCGCCAGCGCGGCTTCC




(SEQ ID NO. 233)







ACATCAACGACCATTTCGGCCAGCTTGCGGCGCATCAGCGGCTTGTCGATGAGCGCCCCACCGAATGCCCGCCGCTGCCCGGCGTATCACATCGATTCGACCATCG







CGCGGCGCGCGTTGCCGAGGGCGAACGAGGCGGTGCCCAACCGCAATCTGTTTGGTCAGCTCCCTCATGCGGGTTGATTCCTTGCCGTCCGGACGGGCCCGCGTCA







TGCGCTCGGTTCGCC







:::::::::::::Rv227T7.seq:::::::::::::







CCGTTGCGCAGCGTGAGCCGATAGTTGACATCCGGCTCGGTGAAGGTGAAATCGATGGCCAGGTCGAGGTCCCATGCGCGTGGGCCATTGATGCCGATCGCCAGGA




(SEQ ID NO. 234)







CGTCAAAGATTTGGTCCGGCGTCAGCTGGGCGAAAAACGTGGGCGCCGGGACTTGCCCGGAGCTGCCCGGGTTCCCGTCGCGCAGCTCGGCGGCCCCGGTCAGAAA







GAAATTGCGCCAGGTCGCACACTCCGCGCCGTAGGCCAGCTGCTCCAGGGTGTCGGCATAGAGCCCGCGGGCCGCAGCGTGCTCGCTGTCGGCGAACACCGCATGG







TCGAGAAGCGTTGCCGCCCAACGGGAAATCACCTGCGTCGAAAGCTTCGCGGGCCAGCTCCAGCACTCGGTCGATGCCACCCAACGCGT






Clone Rv228




:::::::::::::Rv228SP6.seq:::::::::::::







ATACTCAAGCTTGCGGATGTTACCCCTGACAGCGTGAACTATGTCNAAACACACGGCACCGGAACGGTGTTGGGGGACCCCATCGAGTTCGAGTCGCTGGCGGCCA




(SEQ ID NO. 235)







CTTATGGCCTGGGTAAAGGCCAGGGCGAGAGCCCGTGCGCATTGGGGTCGGTCAAAACCAACATCGGCCACCTGGAGGCGGCCGCCGGTGTGGCTGGATTCATCAA







GGCGGTGCTGGCGGTGCAACGTGGGCACATTCCCCGCAACTTGCACTTCACCCGGTGGAACCCGGCCATCAACACGTCGGCGACGCGGCTGTTCGTGCCGACCGAA







AGCGCCCCGTGGCCGGCGGCTGCCGGTCCACGCAGGGCTGCGGTGTCATCGTTCGGCCTCAGCGGGACCAA







:::::::::::::Rv228T7.seq:::::::::::::







CCGGTAACCAGATCAGCTCGTCGACCTCACTGCCGGGGGTGAATTCCCCACCGGTGCTGCGCGCTGCCCAGTAGTGCACCTTCTTGACGCCTCGAAAAGGGGAGTC




(SEQ ID NO. 236)







GGTCGGGTAGGTCACCGTCAGGAGCCGCCTACCCAGGTTGGCGCGGTGACCGGTCTCCTCGAGTATCTCCCGCACCGCCCCCACCGGTGCGGTCTCGCCCGGATCC







ACTTTGCCCTTGGGCAGCGACCAGTCGTCGTAACGGGGGCGGTGAATGACAGCGATCTCGACCGGCCCTTCCGAATCGGCACTGCCGGGTCGCCAGAACACCGCAC







CGGCGGCGTACACAATCCGGCCCGCCGAGCGCCGGCGGGCGGACGANTTCTGGATCGACACCTCAACTCCTGCAGGTCAATTCGGCCAAGCTGCTCGCGGTCGTGG







ATGTGGTC






Clone Rv229




:::::::::::::Rv229SP6.seq:::::::::::::







ATACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCACCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGG




(SEQ ID NO. 237)







CACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCGAGGTCTA







TACCGATTTGCGCATCCGCAGCCGCACCCTGGTCGTCTCGTACCGTGCCCTACCTCTGCTTGTCGGGCGGGGCCA







:::::::::::::Rv229T7.seq:::::::::::::







TCCGTACGGCCCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGG




(SEQ ID NO. 238)







AATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTC







GGGGTGGTCGCGACGCGCATGGGCCACCATCCATCCACCAGGTCTGCGCGAATCACCCGC






Clone Rv22




:::::::::::::Rv22SP6.seq:::::::::::::







GGACACATTGCGAACATTGATGACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTCCAATCAAGAGGCCCAAGCCC




(SEQ ID NO. 239)







GTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGCGAAAAACGGTCGCCGTTGCA







CGACATTAAATGTCACGGTATTGTAAATTAAAAAGATACCCACCAACAAGGCAATCAAACTGAGAGCGGTTAAATTGACCGTAAAAGCGTCCGTCATCTGTTTCAC







GGTGTCCCGTTGGGTNTCCGACGTTTCCATACGCACACCGGCCGGCAGTCTTTGTTGGATGCGTGTTGCAGTGGCCTCATCTTTGATGATCA







:::::::::::::Rv22T7.seq:::::::::::::







GCCTGGCCCAGGTGAAGGCCGACCTCGACGCCAAAGCCGCTGATCCGGCACATGAGTCGGTGGACTGGGACTTGAAGTCGCTGCGATGGGCGTGGAACCGAGCCAA




(SEQ ID NO. 240)







AGATGACGTGGCGCCGTGGTGGGCCGAGAATTCCAAGGAGTGCTACTCGTCGGGGTTGGCCGATCTGGCCCAGGGCCTGGCTAATTGGAAAGCTGGCAAGAACGGG







ACCCGCAAAGGCCGGCGGGTGGGCTTCCCGCGATTCAAATCCGGGCGGCGTGATCCTGGCAGGGTGCGGTTCACCACCGGCACCATGCGCATAGAGGATGACCGGC







GCACGATCACGGTCCCGGTGATCGGGCCGCTGCGGGCCAAGGAGAACACCCGCCGGGTGCAACGCCACCTCGTGAGCGGGCGCGCGCAGATCCTGAACATGACCTT







GTCGCAGCGGTGGGG






Clone Rv230




:::::::::::::Rv230SP6.seq:::::::::::::







TAACTCAAGCTTCAAGTCCGCNGTCCGACCCTGTTCGACGGCTACCTGAATCAACCCGATGCCCCGCCGCGGCGTTCGACCCGACAGCTGGTACCGCACCGGCGAC




(SEQ ID NO. 241)







GTCGCGGTGGTCGACGGCAGTGGGATGCACCGCATCGTGGGACGCGAGTCGGTCGACTTGATCAAGTCGGGTGGATACCGGGTCGGCGCCGGTGAAATTCAAACGG







TGCTGCTCGGGCATCCGGACGTGGCGGANGCGGCAGTCGTCGGGGTGCTCGACTATTATCTAGGCCAGCGGATCGTTGCCTACGTAGTCGGCTCAGCGAATGTCGA







TGCGGACGGGCTTATCAACTTTGTTGCCCAACAACTTT







:::::::::::::Rv230T7.seq:::::::::::::







CCATGTCGCCCAACATATCGTCGATGTTCGCGTCGTCCGCCTCGCGCACGTGGTCTGTCACCAGTCAACGTTAACGCCGCCGCACATGTCCTGCGGCCGGGCAAAA




(SEQ ID NO. 242)







ACGTGAAAAACGAGCGGGCGACTGCAATGTCATGACACCGACGCCGCCGATGGGCCCAGGGTCTGGCAGATTCGATCTGTGCGGCCAGTGCCAGCAGCGTCGCCTC







GTCATACGGCCGGCCGACGAGTTGAACCGACATGGGCATGCCGTCGCCGTCGAAGTCCCACGGCACCACGGCCGCGGGCTGGCCGGTCAGATTCCANACTTGAAAG







TACTGAAGCCGCTGCACCACCAG






Clone Rv231




:::::::::::::Rv231SP6.seq:::::::::::::







CGAAAGCGTGAAACAGCTCGCGGCAGCCCCCGACGTGCTGCGTCGGATAGCCGGCGGGCGAAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCC




(SEQ ID NO. 243)







GCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGCCCGGTCGGCAAGCCCGG







CAGTTGCCAAACCCAGCGTGATCNTGCTCNGCTCTNTANTTCGGCGAAGAAGTGGCTCGCCTGATCACCTACCATCGGCCAGGATCTGCGTGTCATCACAACGCTC







GCCAAGGAGGTTGTTGTG







:::::::::::::Rv231T7.seq:::::::::::::







TCCGCCACGCTTCGCGCCGCCCGGCATACGGCGCGTACCGATCTCCGCGTCATACACCGCGGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGC




(SEQ ID NO. 244)







TGATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTAGT







CGCCCGGTGCGCTCGGCCGAGAAGCTGCACCGCCACCACCGCGACACCGTCTTGCACGCGGACCCACCCCGGATCGGTTGTTGGCCAAGGTAATTGGGTCATTCCA







TTTGACGGGACGCCGACCC






Clone Rv232




:::::::::::::Rv232SP6.seq:::::::::::::







CATTCTTTAACAGTTGTTTTGGGCTCGGCATGGTTAGCCAACGTTCTGCGGTCCACCATATCATCTTGGTCCGGTAGCGCTCGTCCGGGGTATGCTGCCGCCGGGA




(SEQ ID NO. 245)







TTCTCGCTGCTATTACTCCCCCCGAAGAACCGCCACCGGTCCAGCGCGTGGGCCGNCGCGGTCCCATCACAAACTGAACCCCCAACAGGGACATGCTTATCGGTAG







GGCGCGCGCCAAGGCGGCAGCAATCGCATCACTGCGCTCTGCGCGTCACTATTAACCCACCCGGACTTCACTTCCACCACCCCGAATGGCGCCCGGTCATTGATCA







TCTGGCGCACCGCGGATAA







:::::::::::::Rv232T7.seq:::::::::::::







CGGTGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCATGCCGATGCCGCGGCCTCGTGGCCACGCATGTACAGCACCACGCCGCGCCCCTCACGGGCGAACATC




(SEQ ID NO. 246)







GCCAGCGCGGCGTCCAGCTGAAGCCCGCAATCGCAGCGGCGTGACCAAACACATCGCCGGTCAAGCACTCCGAATGCACCGGACCAGCACGTCGTCACCGTCGGCG







TTGGGCCCGGCGATCTCGCCGCGGACCATGCGCGACATGTTCCACGTCCTCGTANATGCTGGTGTAGCCGATGGCGCGAAACTCCCCATGACGAGTCGGAATCCGC







GCCTCGGCGACCCGCTCAATGTGCT






Clone Rv233




:::::::::::::Rv233SP6.seq:::::::::::::







CGGCATCTGGCGGCTGAACCTGTTCTTGGGCAACATGCCGAGGATCGCCTCTTCCACCACGCGGTCGGGGTGGCGTTGCATTACCTCACCGATGGTGCGCTTGTGC




(SEQ ID NO. 247)







AGGCCGCCGGGATACCCCGAGTGCCGGTAAACCATCTTGTGCTGCAGTTTGTCGCCGCTGATGGCGACCTTGTCGGCGTTGATCACGATNACNAATCACCGCCANC







GACATTGGGGGCGAACGTCGGCTCGTGCTTGCCGCGCAGCAGGCTGGCCGCCGCGACGCAAGGCGCCAACCACCACGTCCGTGGCGTCGATGACGTACCACCATCG







CGTGGTGTCACCCGCCTTGGGC







:::::::::::::Rv233T7.seq:::::::::::::







GCGGCAAAAATTGAAGCACTCNTGGCCACTNCCGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGTACTGCGTTTCAACACGTCG




(SEQ ID NO. 248)







CGTCGCCCTCCGACCGCGAACATTCTGGGATGGCAGCAACCTGTTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTAGTCGCCCCCGGGCGGCTAC







AGTCTGAAACGCGATGACCATCGATGTGTGGACGCCGCATCCGACNCAACGGTTCCTACACTGTGATATGTTCGCCTCGCTGCGCCGGTGGACGGTGGGTCTATCC







CGGA






Clone Rv234




:::::::::::::Rv234SP6.seq:::::::::::::







CGCGTTGAACTGAAGGGGTGCCGCCCGGCTCGAGCAGGCAAGCCATTTGTTCGATGCGGTTACCGAAGATCTCTTCGGTGACTGCCCGCCGCCGGCCAGCTCGGCT




(SEQ ID NO. 249)







CAGTGTCCGGCGTTGGTCGCCGCGGCGACAATCTTGGCGTCCACGGTGGTCGGGGTCATGCCCGCGAGCAGGATTGGCGAGCGGNCGGTCAGCCGGGTGAACTTCG







TCAAGAGCTGACGCTGCGGTTGGGGAGGCGAATCATGGTCGGTGCGTAGCCTCGACTAGGCCCGGG







:::::::::::::Rv234T7.seq:::::::::::::







TGACAACGCGGCGGCGATTACCCCGCTACCGCAGCAGCATGACGCGGTAGCGAACACCGCCGGATGCAGCGCAGGTGCGTCGATGTGCTCACGGAATCGCCCCGGC




(SEQ ID NO. 250)







ACCGCGATCTCGAGGATCACCAGTGCCACCCCCTGCAGCGCGACACCGACGATTCCGTACACCGCCACGCCGATCAGGCCCTGGGCCACGTGATTGGAGCTGGCGT







ATATGGCGGCGATGGTGACGATGGTCATCGCCTCTTACATTGTGGCGGCCAGAACCACGGCGTTGGGGCGGCGGTCGATGAACACTAGGCGACCANATCCCCGGGG







TCAACAGGTTGACCATCC






Clone Rv235




:::::::::::::Rv235SP6.seq:::::::::::::







CGCGGACATCCCGAACGAGGACACGCGACCGCTTCGGTGTGTGATCTATCAGGGCTCGCACCACGCGCAACCGCTTCCGGCTACCTAGACGCGGT




(SEQ ID NO. 251)







:::::::::::::Rv235T7.seq:::::::::::::







GCATGCGGGTGATGCCGTTCTCAGTGCGCAACAGCGTTCGACGCGGCATACCCAGCCGCACATGCCGTGCACGCCGGNGCCGGGGCGGGAATCT




(SEQ ID NO. 252)






Clone Rv237




:::::::::::::Rv237SP6.seq:::::::::::::







CTCAAGCTTCAGNCCNTCTAAGCGGTCTGCGCGGCGATCGCAAAGATCGCCCTTTGCCGGCGTTGGGGGCTTCTGCTCGGGGGTGTTGTACACCTTCTCGAACACC




(SEQ ID NO. 253)







TCGGCACCGACACCACCACCGTCGGCTTGAACACCGCCAACATCGGCAGCANATCTTGATGTCCTGGTGAATCCACGGTGACTTTGGAGTGGAAGGCGGCCATACT







GATCGCGCGCGCCACCACATGAGCTAGCGGCAGGAAAACCAGCAGCCGCTCACCCTTGCGCAGCAGCGTCGGGTGATATGCCTGGCGCCC







:::::::::::::Rv237T7.seq:::::::::::::







AGTCGAANGTCAGTCCGGTCTCCTCTCCGACTACGGCCAAGAACTGGGGCGACGGTGTCAGTGCAGAACAGCGGAAACTGGTGGCGCCCTAGGCGAGCGAACGCTC




(SEQ ID NO. 254)







ACAAACGGCGGTGACCGCTTCTGGTCGTGCACCATCGAGCCGTGCCCAGCCCGGCCGCGTGCCGTCAGCCGCATCCACTGGATGCCCTTCTCGGCGGTTTCAATCA







NGTACAGGCGACGTTCGCCACCATCGTGCCGGGGCACGGTTAGCGAGAAACGCCGACTTCACCGATTGCCTCGGTGATGxxxxx






Clone Rv23




:::::::::::::Rv23T7.seq:::::::::::::







AGCTTCGCGGCGTGGCGATCGCGGTTCAAGGCGCGCTCTTCGAGCACAACGAGCGAAGACAGCTCGGCGACGGAGCCTTTATCGACATCCGTTCGGGCTGGCTGAC




(SEQ ID NO. 255)







CGGCGGCGAAGAACTGCTGGACGCGTTGTTGTCGACGGTGCCGTGGCGAGCCGAGCGCCGTCAGATGTNCGACCGGGTGGTCGATGTGCCGCGGCTGGTGAGTTTT







CACGACCTGACCATCGAAGATCCGCCGCATCCGCAGCTGGCGCGGATGCGCCGGCGGCTCAACGACATCTACGGCGGCGAACTGGGTGAGCCCTTCACCACCGCCG







GGCTGTGCTACTACCGCGACGGCTCTGACAGCGTCGCCTGGCATGGCGACACCATTGGTCGCGGCAGCACTGAGGACACTATGGTGGCGATCGTCAGCCTCGGCGC







CACCCGCGTCTTCGCGCTGCGGCCGCGTGG






Clone Rv240




:::::::::::::Rv240SP6.seq:::::::::::::







AGCTTCAGCTGATACTCGACCAGCCCCACTCGGGCCAATACGTGAATGTCTAGCATCTTCACCCGTTCACGGGCTANTCGAGTAGTAGACATTGATTAGCCTGAAC




(SEQ ID NO. 256)







GTACCTCCGACGCCAGCTGACGAACGGGTATGACGGATGGATTTCGTGGTGTCGCGCCCGAGGTCAATTCGTTACGGATGTATCTCGGGGCCGGATCGGGGCCGAT







GTTGGCGGCCGCGGCGGCCTGGGACGGACTATCCGACGAACTGGCGGTGGCGGCGTCGTGGTTTGGGTCGGTGACCTCGGGCCTGGCGGATGCGGCGTGGCGCGGC







CCGCGGCGGTTGCGATGGCNCGCGCGGT







:::::::::::::Rv240T7.seq:::::::::::::







CTGGTCATGGACGTTGCTCCGGTAGTGGCTCACTGCCGATCCTCCTCGTTGAGAGTGCCACCTCAGGGTTGGGTAGGGTTGGGTACTCGAAACCAAGTTACCCACC




(SEQ ID NO. 257)







AGTAACACCGTCAAAATATATCCGTTGCATAGGTCAATGCAAGTTGATGTGAGCTACATTGCACCAACTAACTAACCAACCGGTTGGGTTAGCGGTGATCCTGGCC







GTGTCGGTCCTCTCACCTGCGGTGATAGCGATCAAATGAAGAATATGCGGAGTCTAGGGCGGCAGCGCCTGGCANCGTAGATCATCGGCTCACGCGGATGCGGCCT







CTTGGTACGGACATGCGCGCG






Clone Rv241




:::::::::::::Rv241SP6.seq:::::::::::::







CTCGTGAGTAGCACCCCTGTAATTTGGGATCGGCAAAAAGGCGAATCACCGCGTGGCCACGACACGCCGGGAGGGACNATCTCGGGCGGCTAGGGCTTCTCGCGGG




(SEQ ID NO. 258)







AAGGCCCGAACGTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGG







:::::::::::::Rv241T7.seq:::::::::::::







GGATCAACTACCGGCCAACGGTGATTCTTGGGCGCCGCTGACGCGCGAACGACCCAGCGACACATTCAGCAGATGGCCAGCGCGTGCCGGGCCACGATGTTGGTGC




(SEQ ID NO. 259)







TCGGCGGCTACTCCCATGGTGCGGCNCGTGATCGACATCGTCACCGCCGCACCACTGCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGACGATCACAT







C






Clone Rv243




:::::::::::::Rv243SP6.seq:::::::::::::







AGGACCGTCAGCACGGCGACGTGCTACTCGCCGAGCAGTGGGAATCGCTCTGCAGCAAACCATTACTCTGCGCGACGTTCGAGATGACCTTCTGAATGGACGGATC




(SEQ ID NO. 260)







TACCTGCCGCGCGACGACCTGGACCGCGTATGCGTCCGCCTCCGCCTGGACGACACCGGGGCACTCTATGACCCCGACGGACGGCTCGCGGTACTGCTGCGGTTCA







CCGCCGACGCCCGCACGGTACGCGTCGGGACTGCGCTGAGTCCANCCTCGACGCCGTAGCGCTGCTGCTGTGCGGCCATGTCTGGCATCTACCGCCGTCGCTCCCT







TGA







:::::::::::::Rv243T7.seq:::::::::::::







CGACTCTGTTGGCCACTGCGGGTCGATCTTGCGGCCGCCCCGGTCGTGGAACGCCCAGGTCACCCGGCGGCGCACCGCGGTCAGCGCGTCGTTGGCCAGCGTGGTC




(SEQ ID NO. 261)







ACATGGAAGTGGTCGACGACGAGCTTGGCGTTGGGCAGCAGCCCGGGCGTGCGGATCGCCGAGGCGTATGCAGCGGCGGGGTCGATGGCCACCGTACTGGATGCTC







TCCCGGAACTGCGGTGTGCGCGCTTGCAGCCATGCCAGCACCGCCGCGCCGCCGCGGCCTTCATGCTGCCCATAAACCCTGATACCGGCCAGGTCGACNAACCNGT







ATCCCACGGTCAACCC






Clone Rv244




:::::::::::::Rv244SP6.seq:::::::::::::







CACACGGACGGCGGTGCGGACGCAGCTGACGCGCATGGTGGTCAGCATCGCGGCCGGTCTGCTGTTGTATGCCTACTTCGCGCCGCGCAAATGCTGGTGGGCGGCG




(SEQ ID NO. 262)







GTGGTGGCGCTCGCATGGCTGGGCTGGGTGCTGACCCAACTCTCGAACCACACCGGTGGGTGGGCTGGGCTATGGCCTGCCATATCGGCCTGGTGTTCTACN







:::::::::::::Rv244T7.seq:::::::::::::







CCGATATCCGAGCCGATAGCTGGCGGGCTCGGGTGGTNGCCAGCGGCGCTGCGACGAAAGTGTGACCGTCATGAAACAGACACCACCGGCGGCCGTCGGCCGTCGT




(SEQ ID NO. 263)







CACCTGCTCGAGATCTCAGCATCCGCAGCCGGTGTGATCGCGCTTTCGGCGTGTCGTGGGTCGCCGCCCGAGCCCGGCAAACGCCGGCCCGACACAACCCCGGAAC







AGGAAGTCCGGTCACCGCGCC






Clone Rv245




:::::::::::::Rv245SP6.seq:::::::::::::







GCTTCAGGACAAATTGNATCCCTATGCACCCGTTGTCACGCCGATGAGTGAAGACTGCACGCAATCGCCGGAATCCGGCAAAACCCTGCACAAGCGAAATCAACCG




(SEQ ID NO. 264)







GAGGCTGACAAGGCAACGTCGGTGATCCGTACCGCCTGGTTGGACAAACGGCAGAAGGCGCCTCGTCCGGTCCATCTACGCCGAGCACACTGGTGATAGCGCCATC







GGCATCGGTGCGGCCACGGTGGAGACGAACGTCCGCNGGCGTCTGGGTCAGTAACCCGCCGACCAGTTCTCGGGCAAGCTGGTCAACATCGGGCGCCACGTCTCCA







AC







:::::::::::::Rv245T7.seq:::::::::::::







GTTTGGCGGCCTTATTGCACTGAGGTCGTCAATTGACCCACAGCGGAAATGCCGACTATTCGCAGGCCTCCTTCGCCTTGGCTGCCGGAGATGGGCTCCGCGGGAA




(SEQ ID NO. 265)







CCGCATGCAGGTATATGACCTCGGTTTCTCGGGTGCTACCGCGTGCCTTGTCGAGGATGAACTCGGCGTTGGAATTGTCCAGCCGGCCCAATTCATCGAGCGCAGA







TTCGTACACATGGCCGGCGGCGACATACCTTCACCGTGGATCTGCTCCACACGGACCGCCCTGTCGGGATCTGCTCACGGGTAAAGGAATTA






Clone Rv246




:::::::::::::Rv246SP6.seq:::::::::::::







GCGCACTCCTCCTTATCGCTCCGCTCTGCATCGTCGCGGCGCGGTCAGGTGCAAACGCCTTCGGGGGTGGGGGTCCTGCGGAGCACACCGGATACGGAGCGCAACG




(SEQ ID NO. 266)







CGTCGCGTTGTGCGGGCAAACAAGTGTGCAGGNNCCAATGCCATGTCCAGCAGCTTATCAGTGTCGAACGTGCGAACGTCGCGCCTTCGCCGGTGCCTGAATCTCT







ACAAG







:::::::::::::Rv246T7.seq:::::::::::::







CGCTGAAAGCCACCATTCGCGGGTCGGGCGCCGGGCTCGGGCCGCCAGGCTGCTCCGCTCGGTCATGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAG




(SEQ ID NO. 267)







CCATACCGGGCGGAGCTACATCGGCTCGGCCGCCTACTCTTCGGGNCCTCTTTCGAGGTCGAGGTCGA






Clone Rv247




:::::::::::::Rv247SP6.seq:::::::::::::







TGTAATTTGGGATGGGCAAAAAGCAAANCACCGCGTGGCCACAAACGCGGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGCCCGAAACGTACGGCG




(SEQ ID NO. 268)







TTTCAACACGTCGCGTCGCCTCCGACGCGAAATTCGGG







:::::::::::::Rv247T7.seq:::::::::::::







CTTGGGCAACATGCTGAGGATCGCCTTTTTCACCACGCGGTCGGGGTGGCGTTGCATTAGCTCACCGATGGTGCGCTTGTTGCAGGCCGCCGGGATACCCGAGTGCC




(SEQ ID NO. 269)







GGTAAACCATCTTGTGCTGCAGTTTGTCCCGCTGATGGCGACCTTGTCGCGTTGATCACGATGACGAAGTCACCGCCATCGACATTGGGGGCGAACTCGGCTTGTG







CTTG






Clone Rv249




:::::::::::::Rv249SP6.seq:::::::::::::







GCATGCTTCATTATCTAATCTCCAGCCGTGGTTTAATCAGACGATCGAAAATTCATGCAGACGGTCCCAAATAGAAAGACATTCTCCAGGCACCAGTTGAAGAGGT




(SEQ ID NO. 270)







TGATCAATGGTCTGTTCAAAAACAAGTTCTCATCCGGATTGAACTTTACCAACTTCATCCGTTTCATGTACAACATTTTTAGAANCATGCTTC






Clone Rv24




:::::::::::::Rv24SP6.seq:::::::::::::







ATACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGG




(SEQ ID NO. 271)







CACGCCACCGCGACACCACCCGGCTGCGCTACGTCTATCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCATTGTTCNGGCCCTCTTTCGAGGTCGAGGTCTA







TACCGATTTGCGCATCCG







:::::::::::Rv24T7.seq:::::::::::::







TCCGTACTGGTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGG




(SEQ ID NO. 272)







AATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAACCTCGGGTCCG






Clone Rv251




:::::::::::::Rv251SP6.seq:::::::::::::







GTTCTCGCACGATTTCGGATTAGCGGGATGGTCTCAATTGGGTATGCGGGGAAGGCGCTGACATTCGCCGCGATTAGCTGTTTGATGGACCGGGGGTGATTTTTGA




(SEQ ID NO. 273)







TCACGGAAATGGGTGTTTATNCAGGTCGCACGCTTTCATCCGGGGCGGAACG







:::::::::::::Rv251T7.seq:::::::::::::







GGGTGTGCCTGCTGTGTATGCACGGCATACGGACATCCTTCCCCTGAAGACCCGCGGTCGAACAGCCACGTGTCCATCATCANGGGGTCAACCCCGGCCAAGGGCG




(SEQ ID NO. 274)







ACGGCACGCCAAGTTCGCCGACCGTTAACCTAGTGCTGTTAGCTTCATTTGCTGCGAGCAAAACAGCTGGTCGGNCGTTAGGAATGAATTGAAACTCAACCGATTT







GGTGCCGCCGTAGGTGTCCTGGCTG






Clone Rv252




:::::::::::::Rv252T7.seq:::::::::::::







ACTACCCGGCCAACGGTGATNTCTTGGCCGCCGCTGACNGCGCGAACGACGCCAGCGACCACATTCAGCAGATGGCCAGCGCGTGCCGGGCCACGANGTTGGTGCT




(SEQ ID NO. 275)







CGGCGGCTACTCCCANGGTGCGGNCGTGATCGACATCNTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACCAGCCGTTGCCGCCCGCAGCGGACGATCACATCG







CTTTTATTTNNTNTTCNGGAATCCCTCGGGCCGCGCTGGCGGGCTGATGA






Clone Rv253




:::::::::::::Rv253SP6.seq:::::::::::::







ACGTCGGGANACTGTTCGCGTTCATCCTCGTCTCGGCGGATTGGTCTGCTGCGCCGGACCGACCGATCTTCAGCGGGGGGTCACGCTCCGTGGGGTGCCGTTACTT




(SEQ ID NO. 276)







CCGATCGCCCAGTGTGCGCGTGCTGTGGCTGATGCTGAACCTCACCGCGTTGANTTGGATCGGTTCGGGATCTGGCTGGTGGCCGGAACGCNATTTATGTCGCTAC







GGGCGCCGGC







:::::::::::::Rv253T7.seq:::::::::::::







GCTCAAAGGCACTACTGGCACCAAGGCCCACACGTCACCTGTGACTCCTGCGCCGACCCGCCCGAGGTCTGGCCGTTACACCGAACGGGCGAGCCGGGAGTTGGTA




(SEQ ID NO. 277)







CCATCGAACAAGACAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGTC







CGATACCGGCTGCTTACCGAGACATCCACCATGCCACCCGAATCACCGCACGCGCCGAAATCGCACAACAGCTTGACGCCTTGCAGGTTCCGCGATTGGAATTGCC




(SEQ ID NO. 278)







GACGGTCTCTGACGGCGTCGACCTTGGCAGCCTCTACGAGCTCTCGGAATCACTTGCCCAGCAGGGGGTTCGATGAGTGTCACACCGAAGACCTCGATATGGGCGC







AATCCTGGCCGACACATCCAACCGGGTGGTTGTGTGCTGCGGCGCCGGTGGGGTCNGCAANACACTACCGCGGCCGCGCTGGCGTTGCGCGCGGCCGAATATGGCC







GCACTGTGGTCG







:::::::::::::Rv254T7.seq:::::::::::::







CGTCGTCGTCGTGGTATGCGATAGCCATCCCGTCGGGCTACTCGCCATCACCGATCAGCTTCGCCCCGAAGCCGCCGCGGCGATTTCCGCTGCGACCAAACTGACC




(SEQ ID NO. 279)







GGGGCCAAACCGGTATTGCTTACCGGCGACAACCGGGCCACCGCCGATCGGCTCGGTGTACANGTTGGCATCGACGACGTACGGGCCGGGCTACTGCCGACGACAA







NGTCGCAGCCGTGCNGCNGCTGCAAGCTGGAGGTGCCAGATTGACCGTGGTCGGTGACGGTATCAACGACCTCCGGCCTTAGCGGCCGCGCATGTCGCATCGCCAT







GGGCAGCGCCCGAC






Clone Rv255




:::::::::::::Rv255SP6.seq:::::::::::::







GCACGCAATCGAAGTCACCCAAACCGGGCGGGCCAGGCGTCTNACGCCACGTCNACCAGCCGCAACCTCAACCCGGCCACGGCGAGCTCCTGATCAAGGCCGAGGC




(SEQ ID NO. 280)







CATCGGTGTCTACTTCATCGACACCTACTTCCGCTCCGGGCAATATCCGCGCGAACTCCCGTTCGTCATCTGCTCCGAAGTATGCGGCACGGTGGANGCCGTCGGC







CAGGGGTTAC







:::::::::::::Rv255T7.seq:::::::::::::







TCGACTGTGTGGCCACAGATCACGCCCCGCATGCCGAGCACGAGAAATGCGTCGAATTCGCCGCGGGCCGGCCGGCATGCTCGGGTTGCAGACGGCATTGTCGGTG




(SEQ ID NO. 281)







GTGGTGCATACAATGGTGGCGCCGGCTTGTTGANTTNGGCGCGATATCGCGCGGGTGATGAGTGANAACCGGCGTGCA






Clone Rv257




:::::::::::::Rv257SP6.seq:::::::::::::







GAACCTGACACCCTGGTCACGGGTGAGCACGGACTTGATTTCTTCNCTATTGGTCGGCGCTGTTGAGCACACCACGCCGCTGACGGCCGTCGCGTCCTCGCTGTGC




(SEQ ID NO. 282)







TCGGTCTGGTGGAGCGCGCTGCCCGCGGCCNAACATCNTAAATCAAGCGTATTCGTCAACAGATATCATCAATGTCGGCGCTGGACTATTCAAATCATCGATATAC







TGGTGACCTGGTCCTTCGCCATCGATCAATGGCGATAGTCACGCAAATCGTCACGGACATCGTCGGCGTCCCAGCTGGCCCGTGCCAACAGATGCTGCAACCCATC







GGGGTGGTATCACCGCGGTGCTCGGCGATGGTCCACAATTCTTGCGGTCCAAGCCCNAAACATCCCGGGCATGAATTCACCGGCATGCGCN







:::::::::::::Rv257T7.seq:::::::::::::







CTATCGTACCCGCGCCGGTCACCTTCTGGATATCGCCGGCCTGGTCAAGGGGGCGTCCGAGGGAGCCGGGCTGGGTNACAAGTTCCTGGCTCATATCCGCGAATGC




(SEQ ID NO. 283)







GACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCGACGACGACGTGACTCATGTCACCGGACGGGTCGATCCCCAGTCCGACATTGAGGTCGTCGAGACCGAGCTGA







TCCTGGCAGATCTGCAAACCCTGGAGCGGGCCACGGGCCGGCTGGAGAATGAAGCGCGCACCAACAAGGCGCGCAAGCCGGTCTACGAAGCGGCACTGCGTGCCCA







GCANGTGCTCGACGCCGGGCAAGACGCTGTTCGCCGCGGGGGTGGATGCCGCCGCGTTGCGCGACTGAAACTGCTGACCACCAAGCCCTTCCTGT






Clone Rv258




:::::::::::::Rv258SP6.seq:::::::::::::







TACTCAAGCTTCAGGCCGCCACGTCCGCCGTCCGTCGGCGACGTGACCTCGAGCGCCGAGTTCGACTCGACATCGCCGCCGGCGCATGCCGACATGAACGCGGCAC




(SEQ ID NO. 284)







TCACCGCAAGCCCGTCGGACGTCAGGTCGATCGACTCCGCTTCAAGCACCGGATCGTCCGGGCAACTCGCGGCCTCGGCCTGTGCGAACGGCACACCCGTCGTGGC







GGCNCCCCGCGCGGAACTGGGCTCATCACGGTCGTTGCGAGCCGGTCGCGTCACCGCGTACCGACGCCGTC







:::::::::::::Rv258T7.seq:::::::::::::







CCGACATCGAGTGGGCTCGCAGTGACTTGGCGACCTCCAAGCCACCGGTACCCGCCGCGCGGCAAGCCAAGGACGACGACGGCCTTGCCGGATAGCTGCGCCAGGC




(SEQ ID NO. 285)







GTTGCGCCAACTGGCGTCCAGCGTCGCCACGATCGTCAAAGAGCTTCATCTGCCGAGTGTGTCGCCATCTCATGGCTCCAAATATGGAATTAGGTCCCTGGGCCGA







CTGACGACAGTCCCTCAGCGACCGGATTGCGCATCCCGCCTTGTACGCTACTCCGCAAATCCCGGGCTTGCGTCCGCGGAAGCGAACTCGGCGGCGCTACGTGGTG







GTTCACTTCGGCCGTGCGCACTCGGATCGACGGGCCGATGGTGGCCGGGCCCGCGCGCTTCTTGGTCATCCGATTGAGT






Clone Rv259




:::::::::::::Rv259SP6.seq:::::::::::::







ATACTCAAGCTTGTCGCGGTAAACCGCACGCAGGGCGGTGGGTGCGGTGTCAAAGACACCCACACTTCTTTGCGGTTCGGTGATCTCGACACCGGCCGCGAGCCGA




(SEQ ID NO. 286)







CCACCATGCGCGCGTAGATCGGCGATCAGCGCGTCGGCTATCGCCTGGGTGCCGCCCACCGGAATCGGCCAGCCGACCGAATGGGCCAGCGTTGCCAGCATCAGTC







CGGCGCCGGCCGACACCAGTGACGGCAACGGTGAAATCGCGTGGGCGGCAACGCCGGTGAACAACGCGCGGGCATCCTCGCCCGCCAACGACCGCCAGGCAGGGTG







CCTGGGCCATCATCCGCAGCCCGA







:::::::::::::Rv259T7.seq:::::::::::::







TGGACTCATAACGATCGGGTCAGCGACGCGCCAACACGAACGGCCGGACGAGTGGGCCAGGGTCGCGCCTCCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAG




(SEQ ID NO. 287)







GCTCCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGCTTGTTTCCTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTA







CCCGCAGGCAACCTCCCAAAAATGCAATCCCCCAAAATGCAATGCGTCGAGCTATTTCTCACACCGACCGCTAGTTGCGGATCAGAAATCCGTTGGGCGCGGAAGT







CCAGCCGAATTTGTTCTCCCGCTCCGCATCATGCTTGTAATCGTTTGGAAATCATCCTCATATGCCTCGATCGCTTCATAGGTCAAGCCCAAACCCGGCAGGATGG







GTGGCC






Clone Rv25




:::::::::::::Rv25SP6.seq:::::::::::::







CTTTACACTTTATGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTG




(SEQ ID NO. 288)







ACACTATAGAATACTCAAGCTTAGTGGTTGCGCACGTAAATTCGTCAGGTGACCGATCCCCTGCTGTCTCACTCGCCTCACAGCGACCACCACGGCTGGCGCTCAA







GGCGGGCACGTGCGGAGCAGATGAGGAATGTGCGACGTCTTGATGCAGCCTGTCAGAACACCGAGACCCTCGACGAACTTACGATCGAAACCGCTTAGGCCAACCG







GTGACGGGGGTGTCTTTCCGCGGCTAGGGCGCCTTATCGTCCGAAGGCCGTGGGTGGTGATCGCCTTCTGGGTCGCGCTTGCGGGTCTGCTTGCGCCGACGGTGCC







GTCCCTGGACCGATCTCCCAGCGGCATCCAGTGGCGATTCTGCCATCGG







:::::::::::::Rv25T7.seq:::::::::::::







CAGGCATGCAAGCTTGCGATGTATCAACACGCCGTTGCGCAGCGTGAGCCGATAGTTGACATCCGGCTCGGTGAAGGTGAAATCGATGGCCAGGTCGAGGTCCCAT




(SEQ ID NO. 289)







GCGCGTGGGCCATTGATGCTGATCGCCAGGACGTCAAAGATTTGGTCCGGCGTCAGCTGGGCGAAAAACGTGGGCGCCGGGACTTGCCCGGAGCTGCCCGGGTTCC







CGTCGCGCAGCTCGGCGGCCCCGGTCAGAAAGAAATTGCGCCAGGTCGCACACTCCGCGCCGTAGGCCAGCTGCTCCACGGTGTCGGCATATAGCCCGCGGGCCGC







AGCGTGCTCGCTGTCGGCGAACACCGCATGGTCGAGAAGCGTTGCCGCCCAACGGAAATCACTGCGTCAAAGCTTCGCCGGGCCACTCCAGCACTCCGTC






Clone Rv260




:::::::::::::Rv260SP6.seq:::::::::::::







ATACTCAAGCTTGACCGACGCTGATCGCACCGCACGCGGGAACCTCAAGGGCACTACTGGCACAAGGGCCCACACGTCAACCTGTTAACTCCTGCGCCGACCCCGG




(SEQ ID NO. 290)







CCGAAGTCCTTGGCGTTAACACCGAACGGGCCAACCCGGGAATTTGGGTTCCATCAAAACAAATAGCAGGTGCCTGGGCGGAGTGTTC







:::::::::::::Rv260T7.seq:::::::::::::







GTCGTCGTGTGCTGGGGCGTCCGTATCAGCACGCCCACGAAATGGGGCACAAGAAGGATTCCTGGAACGGTGGCTGTCCAAGATCACCCTCGCCCAAAACTGCTAC




(SEQ ID NO. 291)







GGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGCGGTGTCCACACCGGGAGG






Clone Rv261




:::::::::::::Rv261SP6w.seq:::::::::::::







ATATGCCTTGCTGAGCTTTTCGGATCGCAGCGAGTCGTACCCGCGCCGGTCACCTTCGTGGATATCGCCGGCCTGGTCAAGGGGGCGTCCGAGGGAGCCGGGCTGG




(SEQ ID NO. 292)







GTAACAAGTTCCTGGCTCATATCCGCGAATGCGACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCGACAACGACGTGACTCATGTCACCGGACGGGTCGATCCCCA







GTCCGACATTGAGGTCGTCGAGACCGAGCTGATCCTGGCAGATCTGCAAGCCCTGGAGCGGGCCACGGGGCGGCTNGAA







:::::::::::::Rv261T7.seq:::::::::::::







GACACCCTGGTCACGGGTGAGCAGGACTCGATTTCTTCGCTATTGGTCGGCGCTGTTGAGGCACAGCACGCCGCTGAGGCCGTCGCGTCCTCGCTGTGCTCGGTCT




(SEQ ID NO. 293)







GGTGGAGCGCGCTGCCCGCGGCCGAACATCGTAAATCAAGCGTATTCGTCAACAGATATCATCAATGTCGGCGCTGGACTATTCAAATCATCGATATACTGGTGAC







CTGGTCCTTCGCCATCGATCAATGGCGATAGTCACGCAGATCGTCACGGACATCGTCTGCGTCCCAGCTGGCCCGTGCCAACAGATGCTGCAACCCATCGGGGTGG







TATCNCCGCGGTGCTCGGCGATGGTCCAACAATTCTTGCGGTCCAAGCCCGAAACCATCCGGCCATGAGTTCACCGGCATGGCGCAACGGCTGGTGCCGGGCAAAA







CGCGGCGCGATCGAATTC






Clone Rv262




:::::::::::::Rv262SP6.seq:::::::::::::







TGTAGAAGGTGGGTCCCGTCCAACTTCGCGGCGGCGGCGCGATATGCCTTGCTGGTCTTGCTCATTTGATATCCAATCTATGGGTCGTGGTTACTCAACGGGCCGA




(SEQ ID NO. 294)







AGCTGGCCCTCCCACGGGTAGGGTCCTATTCGACGGTGATGTCC







:::::::::::::Rv262T7.seq:::::::::::::







CCCGAATCCGGTGGCCGGCAGGGGGCCTGGCGACGTGGACACCTTCTAACTTGTCTTTACCGGTCACTGTTGCACCCCAACACCTTTAACGACGTGGACGGACGTT




(SEQ ID NO. 295)







ACATCGGATTCGACGGTGTCATCCACAGCGTTGCCATTGGGCACACCCACTACGCCAATTTCTCCGACTGGGACACCTACCGCAGCCTCGCCCCACTGCAGGGACT







GTTGTTCCCGCAACGGGCCATCGACATGATCCAGTCGTTGGTGACCGACGCGGAGCAGACTGGTGCGTATCCGCGTTGGGCGCTGGCGAAATTCCGCCACCGGCAT







GAT






Clone Rv263




:::::::::::::Rv263SP6.seq:::::::::::::







TTGAGATGCTGGTCGGGATGCCGATGGTTGGAACATGGTCCCCTGGCGTCGAATACGCGCGAGCGCATGAGCTCACCGGTTCGGAACAACGTATCGAAGAACTCGC




(SEQ ID NO. 296)







ACTGCTGGCAGATGGTATCTCCGATGTGGTTGTAATTTGTATCCCAACTCTAACTGTGCTATCGGATCTGCGTGAATA







:::::::::::::Rv263T7.seq:::::::::::::







CGTAATCACGATCCCGCTGAGACACTTGACCTTACGGCCGAAGTGACTTCGCTGCTGCTATGCCGACACCCGATTTCCATACGCTGCTGTACACGACGGCCGGGCC




(SEQ ID NO. 297)







GGTGGCCTCCATCACGCTCAACCGCCCGGAACAGCTCAACACCATCGTCCCGCCCATGCCCGACGAGATCGAGGCCGCTATCGGGTTGGTCGAACGCGACCAGGAC







ATCAAGGTCATCNTNCTGCGCGGTGGCGGGCGCGCCTTCTCCGGCGG






Clone Rv264




CAAGCTTAAGCTGGTTCCGGCCACTCCATGAGCCGTAGTGCAATGGTTCGTGCACGGCGAGGCCGAACTTGCCATAAACATCCCTGACGAAAGTCTCCGGCAAGCC




(SEQ ID NO. 298)







GATTGCTTCTTCGGGCCGCTTCTTGTGGATTGTCCGATAACCCGGTCCCTCATGCTGGAAGTTGTGCGCACTCTTTCCTTCCGCGATGTGGGCTAACGACTCGTCA







TTGAGCAAGAAGTACGTGCACAGGCATCGTCCGCCGGGCTTCAGCACGCGGGAGATCTCGTCCAGATAGTGCTCCACGTCCGGNGGGAAACATGTGGGTGAACACC







GAGGTNAGAAACACCNCATCCAACGACGCATCCGGGATATGGAAAGCGAAA







:::::::::::::Rv264T7.seq:::::::::::::







TATGGTCTTCGTCGACCAGTACGTCGTAGGCGCCATGAGCCAGCGACTGAAGCCGCGCCATGCCTGCACGGCCCGCTCATCCAGCGAGGCGGCCATCTCCCGCAGA




(SEQ ID NO. 299)







TAGCCTGCCGCCTCGGCGCGCACGCTGTCCGGATCGCGTCCGAGCTCGTCGGCCAGCGCACGCAGCCGCTCGTCATACCATCGGGCATCCAGCAGTTGGGTAACCT







CAACGGGGTCGGTCGCTAGCGGCGTCATTGATTCAGCAACAATACCGATGCGCTGCAGCAACTTTCGCAGTCCGATGCGGCCCACCTCCCGTGCAGTCACTGGCTA







GCCCCCGTCATGCCGGTTGTGTCGATGGCACGGCAGCGGGCTCGTAAACCTGCGGTCTCAGCTCGCTGG






Clone Rv265




:::::::::::::Rv265SP6.seq:::::::::::::







GCTTAGCGGTCTTGCTCGAACCGACATTGCGTGCCACTCATGAGCGGGTGGCGGTCGCGGTGCTTACACATCT




(SEQ ID NO. 300)







:::::::::::::Rv265T7.seq:::::::::::::







GTATCTGGCGCCTCTCGAATATCCTTGAACGTCCCGCGGTGCCACCCAGATAGATCGCAGCGCCCTGCAATGGAGTTCCCTTTATGGCCTCTCTAGCCTCCCGCTT




(SEQ ID NO. 301)







GATCGGCTCGACCCGAGAGATGCCCTCGGGCGTTGCGGGATCTCCCTCCA






Clone Rv266




:::::::::::::Rv266SP6.seq:::::::::::::







CTTCACGCCGATCCGCGACCGCGAACGCGACGGTGACGGTGGGCGACAAGGTTCGGTTGGTCGCCGCGGCGCTGGGCGATATCAGCTCACCCGGTTTCGAGGTGTT




(SEQ ID NO. 302)







CGGCGACCGGACGGTGCTGCAGACATTCTTGAGCGTCCTCGACCGGCCCGATTCGGCCTTCAACATCGTGACGCCGTATTTCGGCGGTACCGCTCGGCGCCGAGTC







GAAGGCGGCCTGAGCTAAAGCCGGGCATTGCGCGAGTGGTAAACAAGTTCGGTGACTTCGGTTGACCGACTCGACGGGCTCGATCTGGGCGCGCTGGACCGGTATC







TGCGTTCGCTGGGGATCGGGCCNACCGCNANTTGCGTTGCGANCTGATTCCGGTGGAGCTCCAATCTGACTTCCGG







:::::::::::::Rv266T7.seq:::::::::::::







GCAGCTACCGACCCTAGCGACGAGTGTGTTCGCAGCGTCGAATGTGAACGTTCGGCGTGATTCGGCGCGCGGGTTCCCGCTCTCAGCGCACGTTCGGCGCCGAGGN




(SEQ ID NO. 303)







GGCTAGTCCCTGGTTAAGCAATGTCTCGGTCGCCGCCAGCAGCGCGCATGTCGCCAACCCGTCNACCGCGTTGCGCATGTCCGGTACCGACGGAAACGACGGCGCG







ATCCGGATGTTCTTGTCGTCCGGATCCTTTCGATACGGGAACGACCCCCCGCCTCGGTCACCGCGATACCAACGTCCTTAGCCAANGCTACNGTCCGGCGCGCGGT







CCCGGGCAACACGTCGAAGCTGATGAANTAACCACCCTTGGGCTCGGTCCAAGANGCGATCTTGGACTCCTTAACCGCTGATNCAA






Clone Rv267




:::::::::::::Rv267IS1081N60.seq:::::::::::::







TCCCCATCGGCGCCGGACCGTTTGAAAGTCCAAGCACGGGTGGGATGGAATCGACGACAGTTGAGCGCCGTCGGTGGCCGTGGTCAGCAGCTGTTCGCGAACGCAC




(SEQ ID NO. 304)







CAGGTCACATCCCTTCGACATCTCACCGACGTGGCACGGGCGACATCAACAGGAAGATTGACGAATCCCTCGCAGGCGCGGCACGTCCGCAGGCCAACGCCAACTA







CGGGGCCACCAGCGATCCTCCGCTCACGCACCAGCCCAAGCCAGGCTCANCCACCCAAGTCGGCCCGCGCTCTCCCTCGCCCCCTGGTCTCCGGGGCCTTGTTAAA







CAACTACCGGAAGTCCACCAATCCTCGCTGCATCTCGACACCGTCCGCCTCACTCCCTTCCTCCCGCCCCTCTCCACACNACACACCTCTTGCATTAAGGTCACGG







AGCGGTCACTTTTCGTCGGACGAAATTCGCAATCCGGCCGCTCGCCGCCAGAGAT







:::::::::::::Rv267SP6.seq:::::::::::::







CGGAAAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCAGCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCT




(SEQ ID NO. 305)







GGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGCAAATCACGGTGGCGGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGT







AGCCCGCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGGCGA







:::::::::::::Rv267T7.seq:::::::::::::







GGCCGAGTCCAGCACTTCGCACTATGTGCAGACCAAANACCCGGTGGTCGCCGCGCTGCGGCAGCGGCTGGCAACGGCGCCGGTGATCACCGAGTGGTGCGNAGTT




(SEQ ID NO. 306)







GCCGACCGGCAGTTCGCCGCGGGCTTACTACGAGAAGGGCCTGCGCGACGTCATCAGGTATCACGTGTCGATGACGTCGAGCGTTAACTTCCCCGACCAGACGGCG







ACCTCGCCGATGGACCCCGCGTTGTACCTGGTGTGGGCGCAAGCTAACGCCGCCGCANGCTATCGGTACTCGGTCGAAGCGCAGCCGGGGTCGCAAGCGCTAGCGG







GCAAGGTCGCGACGATCTCGGTCACCTGGACCAACTACGGCGCTGCTGCCGCCACCGAATAGTGNGTGCCCGGCTACCGGCTGGTGGATTCCACGGGACATGTGGT







TCGGACCTGCCGGCAGCGGTGGAACTGAAGANGCTGGTCT






Clone Rv268




:::::::::::::Rv268SP6.seq:::::::::::::







AGCTTCAAGGACATCGTCATCGCGACCAAAACCGCGAGCTAGGTCGGCATCCGGGAAGCATCGCGACACCGTGGCGCCGAGCGCCGCTGCCGGCAGGCCGATTAGG




(SEQ ID NO. 307)







CGGGCAGATTAGCCCGCCGCGGCTCCCGGCTCCGATTACGGCGCCCCGAATGGCGTCACCGGCTGGTAACCACGCTTGCGCGCCTGGGCGGCGGCCTGCCGGATCA







GGTGGTATATGCCGACAAAGCCTGCGTGATCGGTCATCACCAACGGTGACAGCAGCCGGTTGTGCACCATCGCNAACGCCACCCCGGTCTCCGGGTCTGTCAN







:::::::::::::Rv268T7.seq:::::::::::::







GCTCGCGGTCCAGCAGCAGACGTGTCTGACCCCGACGCCCGGCCGCCGGTACCGAAACCGGATCGGCCCGCCGATGGCCGCGGCCACGGCGTCTGCCTTACCCGGC




(SEQ ID NO. 308)







CCGGATACCAGCAGCCACACCTCGCGGGAACGCTGAATCGCCGGCAGGGTCAAGGTGATTCGGCGTGGCGGCGGTTTCGCGAATCGTCCACCGCCACCACCATGCG







GGTGCTCTCGAAGACGCGGGGCTGTGCGGGAACAGCGAGTTAATGTGGCCCTCGGGCCCCATGCCCAGCAGGTGGACGTCGAAATTCGGCCCGGGTCACCTGGTGC







GGCACTGGCGGCC






Clone Rv269




:::::::::::::Rv269SP6.seq:::::::::::::







AGCTTGTCGATCGTCCGGCAGCGTCCGGCGAGTCAAGTCGAAGCCAGTCCGGTCTCCTCTCCGACTACGGCCAAGAACTGGGCGACGGTGTCAGTGCATACCAGCG




(SEQ ID NO. 309)







GANACTGGTGGCGCCCTAGGCGAGCGACCGCCTCACAAACGGCGGTGACCGCGTTCTGGTCGTGCACCATCGAGCCGTGCCCATCCCGGCCGCGTGCCGTCAGCCG







CATCCACTGGATGCCCTTCTCGGCGGTTTCAATCAGGTACAGGCGACGTTCGCCANCATCGTGCCGGGGCANGG







:::::::::::::Rv269T7.seq:::::::::::::







TTGGTGATCATCGNCCCAACGACCCCGAGGCGATGTTCTTGCACACCGAGGAGTGTCGCAAGCTGGGGCTGGCCTTCGCCGCCGATCCGTCTCAGCAGCTGGCGAA




(SEQ ID NO. 310)







GCTGTCGGGGTGAGGAAATTCGCAGGCTCGTCAACGGTGCTGCTTACTTGTTCACCAACGACTACTAATGGGATCTGCTGCTGTCCAAGACCGGCTGGTCAGANGC







CGATGTGATGGCGCAGATCGACCTGCGGGTGACCACATTGGGTCCTAAGGGTGTCGATTTGGTAGAACCTGACGCACCACCATCCACGTCGGCGTTGGTCCCCGAA







ACAGCCAGACCGA






Clone Rv26




:::::::::::::Rv26SP6.seq:::::::::::::







GGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAG




(SEQ ID NO. 311)







CTTGATTTTGATCATCATGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGGCTTTCCGTA







TTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTGCTGATTT







CCCGGTTGAAAGAGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTTCGCCGTTAC







CATGTCGTTGTTTGTGTTCAGCGATTTGCGAATT







:::::::::::::Rv26T7.seq:::::::::::::







CAGGCATGCAAGCTTGGCGTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACC




(SEQ ID NO. 312)







TCGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCG







GATCGCGGTGATCGTCGATGACGGCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCNCCCGGGCGCACG






Clone Rv270




:::::::::::::Rv270SP6.seq:::::::::::::







GGCATCTTGGCCGCCATGTTAGCCACACTGCCACCGGCTATAGAAGCGATGCGCACCGTCCTGCCAGCACATTGCGGCGCTCCTCCCTGGAAAGCAAGATAACCAA




(SEQ ID NO. 313)







GCTCATGCCGTGGTTGTGGGTGGCGTGGTTTGGTTTGGGTAACTTTGG







:::::::::::::Rv270T7.seq:::::::::::::







TCGGCTAATAATCGTCGACGCCGGCCTCCTCTGCAATCGCCTTGGCGGTCGCCGGGTTGTCACCGGTGATCATCACGGTGCGGATGATCATTCGGCGCATTTCGTC




(SEQ ID NO. 314)







GAATCGTTCCCGTATGCCCACCTTGACGATGTCCTTCAGATGGACGACGCCGATGGCCCGCGCGCTGCTGTTATCGGTCCATTCCGCAACGACTAGGGGTGTCCCC







CGCCGGAGCTGATGCCGTCGACAATGGCACCCACCTCCTCGGTGGGGTGGGCACCGTGATCGCGAACCCACTTCATCACCGCAGCCGCGGCACCTTGCGGATTCGA







CGGATG






Clone Rv271




:::::::::::::Rv271SP6.seq:::::::::::::







CTCAAGCTTGGAGGCGTGGCGATCGCGGTCCAAGGCGCGCTCTCCGAGCACAACGAGCGAAGACNGCTCGGCGACGGAGCCTTTATCGACNTCCGTTCGGGCTGGC




(SEQ ID NO. 315)







TGACGGCGGCNAAATAATGCTGGACTCGTTGTTGTCGACGGTGCCGTGGCGAGCCGAGCGCCGTCAGATGTACGACCGGGTGGTCTATGTGCCGCGGTTGGTGAGT







TTCCACGACCTGACCATCGAAGATCCGCCGCATCCGCTGCTGGCGCGGATGCGCCGGTGGCTCAACTAATTCTACGGCGGCGAACTGGGTNATCCCTTCNCCACCG







TCGG







:::::::::::::Rv271T7.seq:::::::::::::







CCTAGGTCAACCGTACCGTCATCGGATCGGGGTCGACCGCACAGATGGACTGGAGCTTCGGCGAGGTCATCGCCTATGCCTCGCGGGGGGTGACGCTGACCCCGGG




(SEQ ID NO. 316)







TGACGTGTTCGGCTCGGGCACGGTGCCCACCTGCACGCTCGTCGAAGCACCTCAGGCCACCGGAAATCATTCCCGGGCTGGCTGCACGACTGCGACGTGGTCACCC







TCCAGGTCGAAGGGCTGGGCGAGACGATGCAGACCGTCCGGACGAGCGGCACTCCTTTTCCGTTGGCTCTTCGGCCGAATCCGGACGCCGAACCCGACCGGCGCGG







GGTCAACCCGGCACCGACGCGGGTGCCGTTTACCCGCGGGCTGCACAAATCCCGACGGGTATGGGCTTTGACCTGCCGACGGGGGA






Clone Rv272




AGCTTGGCGTGACACCAACACAGGGCACTTAAGATGGCAATGCGCCGCCTACCTGCACGTTTTCGCGATGTCAGAGGATGCCGAGGGGAGAACAATGCGAGCACGG




(SEQ ID NO. 317)







CCGCTGACGTTGCTCACCGCTTTGGCGGCGGTGACATTGGTGGTGGTTGCGGGCTGCGAGGCCCGAGTCTAGGCCGAAGCATATAGCGCGGCCGACCGCATTTCGT







CTCGACCGCAAGCGCGACCTCAGCCGCAGCCGGTGGAGCTACTGCTGCGCGCCATCACGCCGCCTAGGGCTCCGGCGGCGTCGCCGAACGTCGGGTTTGGCGAACT







GCCTACCCGGGTCCGGCAGGCAACCGAT







:::::::::::::Rv272T7.seq:::::::::::::







TCATGCCGTTGGACCGACCATCGGAGTTAGTTGCCGAACCGCGGGACCACCGCAAGCACCCGGTCCTGGTCGCGCACCGCGTCGGCCAACCGCTTGAGCACCACCA




(SEQ ID NO. 318)







CGCCGCAGCCCTCGCCGCGCACGAATCCATCCGCGTTGGCGTCGAAGCTGTTGCATCGGCCGGTCGGTGACAGCGCCGACCACTTGGACAGCGCGATGGCGGTGAA







CGGTGACAAGGTGAGCTGCACCCCGCCCGCCAATGCCACGTCGGTTTCACGCAGGCGAAGCTCTGACACGCCAAGTGAATTGCCACCAGCGACGACGAACAAGCGG







TATCTACGGCGATGG






Clone Rv273




:::::::::::::Rv273SP6.seq:::::::::::::







GGGTCGACTTTCTGCAAGGCGAGGCTACACCGTCGTCGTCGTGGTATGCGATAGCCATCCCGTCGGGCTACTCGCCATCACCGATCAGCTTCGCCCCGAAGCCGCC




(SEQ ID NO. 319)







GTGGTGATTTCCGCTGCGACCAAACTGAACGGGGCCAAACCGGTATTGCTTACCGGCGACAACCGGGCCACCGCCGATCGGCTCGGTGTTCAGGTTGGCAT







:::::::::::::Rv273T7.seq:::::::::::::







AATCCGAAATCCTGACCGATACTTGAACCTGGTCTCGTTCGGCAATAACTCGTCGGCGTGCAGGACGCGGCGCAAACGTACTTCGGCATCAACGCGTCCGACCTGA




(SEQ ID NO. 320)







ATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCTAACAGCACGCTCTTCCCGTACACCAACCCCGACGGCGCGCTGGCCCGGGCGGAACGTGGTCCTCG







ACACCATGATCGAAAAACCTTCCCGGGGAGGCGGATGC






Clone Rv274




:::::::::::::Rv274SP6.seq:::::::::::::







TTCCGAATTTCGGGTCCNGGTCATATGACCCTCATGGAAGAAGAAGCGGCCGCCCCGCGCCCGTGCGACGGCGAATGAAAACCCTCACCCAGGCCGCATTGAACGC




(SEQ ID NO. 321)







CGACAAGACGGTGGAGCAGGTCGAAGACGTCCTGGACGGTCTGGGTAAGACCATGGCCGAGCTGAACAGCTCGCTGTCACAGCTGAACAGCACCGTGGAGCGCTTG







GAGGACGGTCTGGACCATCTCGAAGGTACCCTGCACAGCCTGGACGATCTCGCGAAACGGCTCATCGTGTTGGTCGAGCCGGTGGAAGCCATCGTCGATCGGATCG







ACTACATCGTGAGCCTCGGCGAAACGGTGATGTCACCGCTGTCGGTC







:::::::::::::Rv274T7.seq:::::::::::::







NCTCGATCTTGGGGTACGTTCGATGAGGCTGCTGACCAACAACCCGGCCAAGCGGGTGGGACTGGATGGATACGGATTGCACATCATCGAGCGCGTGCCGCTGCCG




(SEQ ID NO. 322)







GTGCGGGCCAACGCGGAAGAACATCCGTTACCTGATGACCAAGCGTGACAAATTGGGGCACGACTTGGCTGGGTTGGACGATTTTCACGAATCCGTGCATCTGCCC







GGAGAATTCGGCGGTGCCTTGTGAAGGTGGCGCCGGGGTGCCGGATCTGCCGTCGCTGGATCGTCTGGTGTGCGGCTGGCGATTGTCGCCAGCAGCTGGCACGGAA







AGATCTGCGACGCGCTGTTGGACGGCGCCCGCAAGTGGCCGCCGGGTGTGGCCTCGATGACCGACTGTGGTTCGGGTGCTCCGCGCGATCGATAT






Clone Rv275




:::::::::::::Rv275SP6.seq:::::::::::::







TCATCCCGACCAAAACGCGAGCTAGGTCGGCATCCGGGAAGCATCGCGACACCGTGGCGCCGAGCGCGCTGCCGGCAGGCCGATTAGGCGGGCATATTATCCCGCC




(SEQ ID NO. 323)







GCGGCTCCCGGCTCCGAGTACGGCGCCCCGAATGGCGTCACCGGCTGGTAACCGCTCTTGCGCGCCTGGGCGGCGGCCTGCCGGATCAGGTGGTAGATGCCNACAA







AGCCTGCGTGATCGGTCATCACCAACGGTGACAGCAGCCGGTTGTGCACCAAGCGCGAACGCCACCCCGGTCTCCGGGTCTGTCCAACCGATCGACCGCCCAAGCC







CACATGAACAAACCCCGGCATCACGTTGCCGATCGGCATACCGTGA







:::::::::::::Rv275T7.seq:::::::::::::







TTGGCGGGTTGGCCCAGCAGCCCGCCGGTGACGGCGACGATGCTGGGCTGGTTGCGGCCCTGCGCCACCGCGGCTTGCATGCTGGTTGGCTGTCTTGGGACGATCC




(SEQ ID NO. 324)







CGAAATAGTCCACGCGGATCTGGTGATTTTGCGGGCTACCCGCGATTACCCCGCGCGGCTCGACGAGTTTTTGGCCTGGACTACCCGCGTGGCCAATCTGCTGAAC







TCGCGGCCGGTGGTGGCCTGGAATGTCGAGCGCCGTTACCTACGTGACCTGATGGATCGGGGGGTGCCGACCGTGCCCGGCGATGTGTATGTGCCGGGANAGCCGG







TCCGGTTGCCACGCAAAGGCCATGTCTTCGTCGGTCCGACCATCGGTACCGGGACACGGCGCTGTATTGCCCGGTTCGCTGCCGAGTTCGTCGCGCAACTGCACGC







NGGCGGGCCAGCGGTGCTCGTTCANCCCGGAGGTTCCGGTGACGATGATCGTGTTGGTCTCCCT






Clone Rv276




:::::::::::::Rv276SP6/seq:::::::::::::







GTAGGAGAGAACAAAGACCGTCGATAGGACACGTGTTACGCCGGTAGCTGTCATTGGTATGGGGTGCCGCTGCCGGGGGGCATCTACTCACCCGATCGGTTGTGGG




(SEQ ID NO. 325)







AGGCGTTGCTGCGGGGCGACAATCTGGTCACCGAGATCCCCGCCGACCGCTGGGACATCTACGAGTACTACGACCCCGAACCCGGCGTGCCCGGACGCACCGACTG







CAAATGGGGCGCGTACCTCGATAACGTCGGCGACTTTGATCCCGAGTTCTTCGGGATCGGGGAGAAAGAAACGATAGCGATCGATCCGCAGCACCGCTTGTTGCTG







GAAACCTCCTGGGAAGCCATGGAACACGGCGGGCTAACACCGAACCATATGCCTCCCGACANGGGTTTTCGTGGGGTT







:::::::::::::Rv276T7.seq:::::::::::::







CGAACTGAGCCCATAGAAAGGCAGCGACTAATTCGCTGGGCAAATAGGAAGACCCTTTGTCCTGCCACGTATATTTGTCGACCTCGTTGCGAAGGAAGCGGCTGCG




(SEQ ID NO. 326)







ATTGGTGCCCTTTTCCCTGGAGAATCTCTGCCCGGAGCAGGAAGTCTTATGAGTTGACAAGCAGGGGCGCCGCCTTCGCCGGAAATCACATTCTTGGTCTCGTGAA







ATGAGAGCGCTCCCAGGTCGCCGATGCTGCCGAGCGCCCGCCCACGATACGACGCCATCGCGCCTTGGGCCGCGTCTTCGACCACCGCCAGGTTGTGGTGCGTGGC







GATCTTCATGATCGCGTCCATCTCGCAGGCCACCCGGCATAGTGAACGGGGACCATGGCCTCGGTTCGCGGGTGAA






Clone Rv277




:::::::::::::Rv277SP6.seq:::::::::::::







CTTAGACGCCACCTCCGGGCCGAGCTCCACGGGGTGGATAAGTACGGCCGGATGTGGCCGCAATGGGAAGTTGTTGCCCGCTTGACTGTCCGGGTTAACGCCGGAT




(SEQ ID NO. 327)







TCCACCACATCCCCTTGCGAAAGGCCGTTGGGTT







:::::::::::::Rv277T7.seq:::::::::::::







GATCGCGATCGTCGATGTGGCCATCCGGCTTGGCGTCGACCCGCGTAAGGCAGACCAGATGGTTCGCGGCACGGTCAACCTGCCACACGCACTGGTAAGACTGCCC




(SEQ ID NO. 328)







GCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGCTGATGCTGTCGGATCGACGATCTGATCGAGAGGATCAGGGCGGCTGGCTGG







AATTCGATGCCGCGATCGCGATACCGGATT






Clone Rv278




:::::::::::::Rv278SP6.seq:::::::::::::







AGCTTACGCCGCTTTCGCTTCNGATTTGGGACGCCGCATCGAAAGCGCAGTTGGAAGCGCGGCGCCCGGCTGGTCGAGCTGCTCAAGCAGCCGCAATCCCAGCCCA




(SEQ ID NO. 329)







TGCCCGTTGAGGAGCAAGTGGTTTCGATCTTCCTGGGCACCGGCGGTCACCTGGACTCGGTGCCCGTCAAGGATGTCGGCGGTTCGAAACCGAATTACTGGACCAC







ATGCGGGC







:::::::::::::Rv278T7.seq:::::::::::::







CGACGGGACCTCGTCGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACCGGTATAAGGTCGGCGAAGCGCTCGGCATTGGTCATCGGGATA




(SEQ ID NO. 330)







TGCCGCTCGGGACGGTCAGATGCCCTCGGGTCCNGCCAGCACTCCTCAGGCTTCGTCGGGGTGGTCGCGACCGCATGGGCCACATCGCATTCACCAGGTCTGCGCG







AATCACCAGCACGTANACGGTTCCTTTCCTAAGCAACACCGAAATTTCAGGACCCGAATGCTCCGGGAAAACATGTCACGGTAAGTCCGGTATTCCGGGTACCGGT







TGAGCATTGA






Clone Rv279




:::::::::::::Rv279SP6.seq:::::::::::::







CGGCATCGGTTTGGGCTGTCACCAGCAGTTGGTAGTTCTTCACTACTGTTGTTCGAGCGTCGAGCCGCCGCGCGTGTCGAGGTCGCCGGACGCGTACCCGCCAGGC




(SEQ ID NO. 331)







CGGTCAGGGTGCCCTTCCAGTCCACGCNGCTGTGGTCGGCTAACCGCTTATCTTCAATCGAGACNATCGCCAGCTTCATCGTGTTGGCGATCTTGTCCGAGGGCAC







CTCGAACCGGCGCTGCGANTACAGCCACGCGATCGTGTTGCCCTTCGCGTCGACCATCGTCGATACCGCAGGCACTTGCCCCTCGAGCAGCTGGGCCGATCCGTTG







GCAACGACCTCAGAGGCACGATTGGACATCAGCCCTAGCCCGCCTGCG







:::::::::::::Rv279T7.seq:::::::::::::







CCGTCGANGCCGCCGACTTGGCTTGACCGACACCAACATGGCCTGAGGGTGTTCAACAAGACCGTGGCCGACGGGCTGAACATCACCATGAGCGGCATGAGCCACG




(SEQ ID NO. 332)







CCACCGAGTTCATCATGTTGATCGCCGAAAACCATTGGCGGGTAGCGGAAGAACGGTCGAGGTGCTCTACACCGAGTATTCGAAGTCGAAAGGCCAACCGCTGCTC







AACGGCGTCAACATCATTTTCGACGGGTTTCTGCGAGGGAGGATGCCACGATGAACTGGATCCAGGTGCTGTTGATCGCGTCGATCATCGGGTTGCTGTTCTACCT







GTTGCGGTCGCGCCGAAGCGCGCGGTCCGTGCCTGGGTCAAGGTGGGCTATGTCTTGTTCGTGCTCCCGGCATCTATGCCGTGCTGAGA






Clone Rv27




:::::::::::::Rv27SP6.seq:::::::::::::







TTACACGNCCTGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGAC




(SEQ ID NO. 333)







ACTATAGAATACTCAAGCTTTTTGAGCGTCGCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATNCGGATCTGACCGAAGTCGCTGCGGT







GCAGCCCACCCTCATTGGCGATGGCGCCGACNATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGNGACGCGGTANGTGGTCAAGTCCGGTCTACNCTTGGG







CCTTTGCGGACGGTCCCGACGCTGGTCGCGGTTGCGCCGCGGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGCGGCACTGNACGGCCAGTGCCGC







GGCGATGTCNGCCATCGGGACATCATGCTCGCGTTCATACTCCTCGACC







:::::::::::::Rv27T7.seq:::::::::::::







CAGGCATGCAAGCTTTGTCACACCAAGTGTTTCGACCAGGCGCTCCATCCGGCGAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGT




(SEQ ID NO. 334)







TCAGCTCGCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCGCAGCTTGGGGATCGCGACGTCGATGGTTGCGGCACGGGTGTCGAAATCACGGT







GGCGGTAGCCGTTGCGCTGATTGGACCGCTCATCGCTGCGTTCGCGGTAGCCCGCCCCGCACAGGGCGTCGGCTTCAGCCCCCATCAAGGCGG






Clone Rv280




:::::::::::::Rv280SP6.seq:::::::::::::







AGCTTAGCCAGTTTTTCTACTCTTGGGCCCACACCCACAGTGCTTCGACGGTACGGTCACCCATGATGGCCATCCAGTTGGCATCGGTGAGCTGATAAATGCCAGC




(SEQ ID NO. 335)







TGGTTTCGCCAACCCGGTAGCGATCTTGGCGCGCTGCTTGTTGTCACTGATACCTATCGAGCAAGACAGCCCGGTTTGCGACAAGATGACTTTTCGGATCTCTTCG







GCGACTTCGATGGGGTCGTCGGGAGTCCCGGGCGCCACCGCGAGGTAAGCCTCGTCCCAGCCCCATACCTCGACCGGGTATCCCAGGTCGCGCAATAACGCCACCA







CCTCCTCGGACGCCGCGTTGTAGGCGGCTGGGTTCGACGGCAAGAAGTGGCCTCAGGGCATCGTCGGCGCGGTCCCAACGGCNTGCCGGCGCGCACACCGTAGGCG







CGGGGCTC







:::::::::::::Rv280T7.seq:::::::::::::







CCGGCGGAACTCAGACGTGCTGGTGGTGCGGCATGGCACCGCGGGCAGCAAAGCGCACTTCTCCGGGGACGACAGCAAGCGACCGCTAGACAAGAGGGGTCGTGCG




(SEQ ID NO. 336)







CAGGCAGAAGCGTTGGTACCACAGCTGCTGGCGTTCGGCGCCACCGATGTTTATGCCGCCGACCGGGTGCGCTGCCACCAGACGATGGAGCCACTCGCCGCGGAAC







TGAACGTGACCATACACAACGAGCCCACCCTGACCGAAGAGTCCTACGCCAACAACCCCAAACGCGGCCGACACCGAGTGCTGCAGATCGTCGAGCAAGTAGGCAC







ACCCGTGATCTGCACGCAGGGCAAGGTCATTCCCGATCTGATCACGTGGTGGTGCGAGCGCGACCGTGTGCCCCCGACAGTCCCGCAATCGCAAAGGCAGCACGTT







GGTGT






Clone Rv281




:::::::::::::Rv281SP6.seq:::::::::::::







GTATGGTCAGCTGTCCATCCGGCGCTGTCGGCCGAGCTGCCAGATCTCGTCAGCCCGTAACCGGGTTGCGGGATCCACGCGTGCGGGTTGTCTAC




(SEQ ID NO. 337)







:::::::::::::Rv281T7.seq:::::::::::::







CCGACTTTCCGCGGGTACCCGCTCAACTTTGTGTCNACCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGA




(SEQ ID NO. 338)







CGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATC







GTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGCGACCCGGCCTATGGTTATTCGACCTCGCCGCCCAATGTTGC







GACTCCGTTCGGTTGTTCCAGAANGTCAGCCCG






Clone Rv282




:::::::::::::Rv282SP6.seq:::::::::::::







GCACCGATGTCGGCGAGCACTTCGTCAACTTCCAGGGGTGCCCGCACCAAGTATTTCGACGAGTATTTCCGTCGGGCCGCCGCCGCCGGTGCGCGGCAGGTGGTCA




(SEQ ID NO. 339)







TCCTGGCGGCGGGGCTGGGACTCGCGCGCGTACCGGCTGCCTCGGC







:::::::::::::Rv282T7.seq:::::::::::::







TGCACCCAACTTACTGAGCATGCTAACGCTGGTCGTGCGGGTCTTGTTCCCGCGTGTCGGCAGGGCACACGCTCGGGGCGTAGCTGGGAGAGGCCCCGGTCAAGCC




(SEQ ID NO. 340)







CGGAGAGCAGTGCTCAGTCCGCCAGCTTGACCGACTTTCGATGAGAACGCGCTTCTCGCCGTATTGAACTGGCGTGCTGACGGTCGCTGAGCAGCGCTCGCCGAGT







GCGGCCGCTGATTCTTTCATCGAGCCAGGACGCGCATTCGTGTTCGGCCGC






Clone Rv283




:::::::::::::Rv283SP6.seq:::::::::::::







AGCTTACGGCCGGTCGACGCGACGAGTGGTTCATGACACCACAAACCGTCAACGCCTACTACAACCCGGGGATGAACGAAATCGTCTTCCCGCAGCGATTTTACAG




(SEQ ID NO. 341)







CCACCATTTTTCGATCCGCAGGCCGACGAGGCCGCCAACTACGGCGGGATCGGGGCGCGTGATCGGGCACGATGATCGGGCACGGTTTCGACGATAGGGCGCCAAA







TACGANGGCGACGCAATCTGGTCNATTGGTGGATCGA







:::::::::::::Rv283T7.seq:::::::::::::







ATGTCGTCACGTCACCACAATCGCGAGGACCCAATCATGCCGCCCAGGGCGGCCAACCCAATGGTGGCCGCGAAGCGGCAGCTCGATCGCAGCGCGGAGGTGCCGG




(SEQ ID NO. 342)







CCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAACGCAAGACCTATATCTGCCGTCGGAGTAAGAATCGAGTAGCCGGTCGACCA







ACGGAAGCGAAAGTGTCCGCGATGTTGATGAGCGTCGCCGGTTGTGGCGGCGGTGGC






Clone Rv284




:::::::::::::Rv284SP6.seq:::::::::::::







AGCTTCACCAGCGTGCCGATGCTGTTCGCNACACCTCCCTACTATGCGCAATTCGCCGACACGGGTGGCATCAACACGGGCGATAAGGTGGACATCGCTGGGGTGA




(SEQ ID NO. 343)







ACGTCGGGCTGGTGCGCTCGCTGGCAATCCGCGGCAACCGCGTGTTGATCGGATTCTCGTTGCCCGGCAAGACAATCGGGATGCAAAGCCGGGCAGCAATTCGCAC







CGACACCATTCTTGGCCGTAAGAACCTGGAAATCGAACCCCGCGGTTCGGAGCCGTTGAAACCCAACGGTTTCCTGCCGTTGGCGCAGAACACTACGCCATACCAA







ATCTATGACGCGTTCGTC







:::::::::::::Rv284T7.seq:::::::::::::







CTGCCGCGGTGGCGGTCAGCGCCTGGCAAGTCACCGCACCGCCGTCCGGTTCATCGGCAGGCTCCCCCGAAAAGGGCCCTGGCAACAGAAGGTGATCAATGAGCTC




(SEQ ID NO. 344)







CCGCAGACCTTCGCCGATCTGGGACCGACATACGTGAAGTTCGGCCAGATCATCGCGTCCAGCCCGGGAGCATTCGGTGAGTCGCTGTCGCGGGGAATTCCGCGGC







CTGCTCGACCGGGTGCCGCCCGCAAAAACCGACGAGGTGCACAAGCTCTTCGTCGAGGAACTCGGCGACGAGCCGGCCCGGCTGTTCGCCTCCTTCGAGGAAGAAC







CGTTCGCGTCTGCGTCCATCGCCCAAGTGCACTACGCGACCTGCGCAGCGGCGAAGAAGTGTGGTCAAGATCCACGGCCGGGCATCCGCCGCCGCGTTT






Clone Rv285




:::::::::::::Rv285SP6.seq:::::::::::::







GATCGTGCCGGCCCCCCGGCGGCAGTAGCAGATCAGCTCGTCGAAATCGCAACAACCAGTCCAGTCGATTTCCATACGGGCGCCGTCAATCAACTCTGCGAACATC




(SEQ ID NO. 345)







GCGATCGGCACCGGAAACCGGCGAGCCGCGTCAGCCAGCGCAACCAGCACCGGGATCGGATGAATCATCAATATTATCAAGTGATTTCCTGATGGCATCGAGCTCG







GTGATCTTGGTCTCGGGGGCCAGCTCGCCGTCGGCGACGTCGTCGATCCGGCGGCCGAGCGCATAGACCGCAAATAGTGCCGCTCGCTTTTCGCGCGGCAAGAGTC







GGATGCCGTAATATANGTTTCTGGCGGCCGTGCGCGTGATCNACTCGGTGATTCGATACGCCTGTTCATCTCGGTCATGCCGTCCTC







:::::::::::::Rv285T7.seq:::::::::::::







GGTGGCGCAATGACCGAAACCACCCCAGCCCCGCAAACCCCGGCGGCCCCGGCCGGGCCCGCACAATCGTTCGTGTTGGAGCGGCCCATCCAGACCGTTGGGCGCC




(SEQ ID NO. 346)







GTAAGGAGGCCGTGGTACGAGTGCGGCTGGTGCCCGGCACCGGCAAGTTCGACCTCAACGGCCGCAGCTTGGAGGACTACTTCCCAAACAAGGTGCACCAGCAGTT







GATCAAGGCACCCCTGGTCACCGTGGATCGGGTGGAAAGTTTCGACATCTTTGCCCACCTGGGCGGCGGCGGCCCGTCGGGTCATGGCCGGCGCGCTGCGCCTGGG







TATCGCCCGGGCATTGATTCTNGTATCGCCGGATGACCGGCCCGCGCTGAATAANGCCGGCTTCTTGACCGTGATCCACGCGCCACCGAACGCAAA






Clone Rv286




:::::::::::::Rv286SP6.seq:::::::::::::







CACAATAGATTACTCAAGCTTCGAACCAGCGGCCTTATCACGTATCCCCGCTGAGACCTTGACCCTTAGGGCCGAAGTGACTTCGCTGCTGCTATGCCGACACCCG




(SEQ ID NO. 347)







ATTTCCAGACGCTGCTGTTACACGACGGCCGGGCCGGTGGCCACCATCACGCTCAACCGCCCGGAACAGCTCAACACCATCGTCCCGCCCATGCCCGACGAGATCG







AGGCCGCTATCGGGTTGGCCGAGCGCGACCAGGACATCAAGGTCATCGTGCTGCGCGGTGCCGGCCGCGCCTTCTCCGGCGGTTACAACTTCGGCGGCGGGTTCCA







ACATTGGGGGCAT







:::::::::::::Rv286T7.seq:::::::::::::







TCAGGACGCTTATGGTTGGCAGATGGTCGCCCTGGCGTCGAATACGCGCGAGCGCATGAGCTCACCGGTTCGGAACAACGTATCGAAGAACGTCGCACTGCTGGCA




(SEQ ID NO. 348)







GATGGTATCTCCGATGTGGTTGTAATTTGTATCCCAACTCTAACTGTGCTATCGGATCAGCGTGAATATCGAGATATTGCGAATGCGATGACAGGCCGCCATTCGG







TTTATTCGCTTACGCTTCCCGGGTTCGATTCGTCTGATGCACTGCCGCAAAACGCGGATATGATTGTTGAAACCGTATCTAACGCAATTATTGATGTGGTAGGCGG







CAGCTGCCGTTTTGTGCTGTCGGGCTATTCATCGGGTGGGGGTGTTTGGCTATGCCCTCTGCTCCCAT






Clone Rv287




:::::::::::::Rv287SP6.seq:::::::::::::







CGCAGCTGTCGCCGATCTGGTCCGGAATACCTAGCTCCAGGTTCTGAGTGGAGATGAGTGCGGCCATCGAAGTGTTGTCAATGTACTCCAGGATGTCAGGTGCCAG




(SEQ ID NO. 349)







GCCGCTGGCGAGGATCTTGGGCACCGCCGCCATGACTTGGTCGAAGTCGGCGAACGGGGCGAGCACGCTGGCGTCGTGGTC







:::::::::::::Rv287T7.seq:::::::::::::







GTAGTTCGTTCATCCAAACACAGTGCGGTACCGGCTCAAGCGGATCACCGACTTCACCGGGCGCGATCCCACCCAGCCACGCGATGCCTATGTCCTTCGGGTGGCG




(SEQ ID NO. 350)







GCCACCGTGGGTCAACTCAACTATCCGACGCCGCACTGAAGCATCGACAGCAATGCCGTGTCATAGATTCCCTCGCCGGTCAGAGGGGGTCCAGCAGGGGCCCCGG







AAAAGATACCAGGGGCGCCGTCGGACCGA






Clone Rv288




:::::::::::::Rv288SP6.seq:::::::::::::







TCCGCTCGCTTCTCCGAGAGGTTGAGTGCCAACGCTCTGCCGATGCCCGAAGCCGGCCCCGGTGATGACGGCGACCTTGCCTTCGAATGAGCTCATTTGACTACTC




(SEQ ID NO. 351)







CCCGTGGTTGTCCCTGCGATTGGTGGAGGTGGCCGCGCAGCCTTGCCCCGAGGTCGGCGATCGCGTCTCGGGCTTCGGGGAGCAGACTGACCTGCAGATGGAAGTC







GTGCCACATGCCCGCGAACCGGCGATGCTCGATGCTTGTTTTCGAAGCGGCGCAGGCGGTTTCGATCTTGTCCGCGTCAACACNGATCGGATCGTCGCCCGCGGTC







TGCATGACGAATGGGCG







:::::::::::::Rv288T7.seq:::::::::::::







ATGGGAGGCCACCGATTACCATCTTGCACACACCGATTCCGGGCTATTGATGTCCACGTTCGGTCCGCGAACCGCGCTGTGGCTGCTGCTGGCCAAAGGCGGAGGC




(SEQ ID NO. 352)







GATACCGAAGTCAGTGCCCAAGCTTGGGTTCCACGCTCGCGCAGCCACGCCGTCACCTTTCCACGAGACCTCACCTGCCGATCCGAAATGGAATCGGCCGTGACGG







AATTGGCGCAGCGAACACTCAACGAGGTGGTGGCTTCGTCGCGAACCGTCACCCGAGTCGCGGTCACCGTGCGCACGGCGACGTTCTACACCCGCACCAAGATCCG







AAAGCTGCAAGCTCCCAGCACCGATCCCGACGTCATCACCGCTGCCGCCCGGCACGTTCTTGAACCTATTCGAGCTGGAATCGGCCGTCCGGTTGCTGGGAATTGC







NGTTAAGAACTGGGCCT






Clone Rv289




:::::::::::::Rv289SP6.seq:::::::::::::







GCTTTGCGCGCTTCTCCGAGAGGTTGGAGTGCCAACGCTCTGCCGATGCCCGAGCCGGCCCCGGTGATGACGGCGACCTTGCCTTCGAATGAGCTCATTTGACTAC




(SEQ ID NO. 353)







TCCCCGTGGTTGTCCCTGCGATTGGTGGAGGTGGCCGCGCAGCCTTGCCCCGAGGTCGGCGATCGCGTCGCGGGCTTCGGGGAGCAAACTGACCTGCAGATGGAAG







TCGTGCCACATGCCCGCGAACCGGCGATGCTCGATGCTTGTTTTCGAAGCGGCGCAGGCGGTTCGATCTTGTCCGCGTCAACGCAGATCGGATCGTCGCCCGCGGG







TCTGCATGAAGAAT







:::::::::::::Rv289T7.seq:::::::::::::







CTCACGCAGCCACGCCGTCACCTTTCCACGAAGACCTCACCTGCCGATCCGAAATGGAATCGGCCGTGACGGAAATTGGCGCAGCGAAACACTCAACGAGGTGGTG




(SEQ ID NO. 354)







GCTTCGTCGCGAACCGTCACCCGAGTCGCGGTCACCGTGCGCACGGCGACGTTCTACACCCGCACCAACATCCGAAAGCTGCAAGCTCCCAGCACCGATCCCGACG







TCATCACCGCTGCCGCCCGGCACGTTCTTGACCTATTCGAGCTGGATCGGCCCGTCCGGTTGCTGGGAGTGCGGTTAGAAACTGGCCTAGAAACCGGCGGGCACAC







CGCACCTGGGCGGGGN






Clone Rv28




:::::::::::::Rv28SP6.seq:::::::::::::







TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT




(SEQ ID NO. 355)







ACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACNCGCGGGTCGGGCGCCGGGCCCGGGTCGCCANGCTGCTCCGCTCGGTGATGGCA







CGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAAGTCGAAGTCGATA







CCGATTGCGCATCCGCNGCCGCA







:::::::::::::Rv28T7.seq:::::::::::::







CAGGCATGCAAGCTTCACGTCCGTACGGCTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCTGCATCTTCCATAGCCCGCCAC




(SEQ ID NO. 356)







ACCTTCAGTTGCTCACCGGAATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAACCCTCGGGTCCGGCCA







GCACTCCGCAGGCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACC






Clone Rv290




:::::::::::::Rv290SP6.seq:::::::::::::







GCTTGTCTATCGTCCCGGCCAGGTCCGGCCAGTCAAGGTCGAAGGCCAGTCCGGTCTCCTCTCCGACTACGGCCAAGAACTGGGCGACGGTGTCAGTGCAGACCAG




(SEQ ID NO. 357)







CGGAAACTGGTGGCGCCCTAGGCGAGCGACCGCCTCACAAACGGCGGTGACCGCGTTCTGGTCGTGCACCATCGAGCCGTGCCCAGCCCGGCCGCGTGCCGTCAGC







CGCATCCACTGGATGCCCTTCTCGGCGGTTTCAATCAGGTACAGGCGACGTTCGCCACCATCGTGCCGGGGCACGGTTAGCGAGAAACCGCCGACTTCACGATTGC







CTCGGTGATGCCGTCGAAACAGATCGGGCCT







:::::::::::::Rv290T7.seq:::::::::::::







GCGCGCCATGTTGAGGTTGTCCGACGGTGACGACGGTGAACCACAACTGTTTGACCTGTCCGCACACACCGTGTGGATCGGCGAGCGGACCCGACAAATCGATGGC




(SEQ ID NO. 358)







GCGCACATCGCGTTTGCCCAGGTGATTGCTAATCCGGTCGGGGTCAAGTTGGGCCCCAACATGACCCCGGAACTGGCCGTGGAGTACGTCGAGCGGCTCGACCCGC







ACAATAAGCCGGGCCGGCTGACTTGGTGAGCAGGATGGGCAACCACAAGGTCCGCGATCTGTTGCCACCGATCGTGGAGAACGTCCATGCCACCGGGCATCAGGTC







ATCTGGC






Clone Rv291




:::::::::::::Rv291SP6.seq:::::::::::::







TTGCCTTCCATGCCGAGCAAGGTCGACTCAGCGATGACGAATTGTTCTTCTTCGCGGGTGTTGCTGCTGGTTGCGGGCTATGAGAGCACTGCTCATATGATTAGCA




(SEQ ID NO. 359)







CATTGTTTCTGACGCTGGCCGACTATCCAGATCAGCTGACACTCCTTGCGCAGCAACCAGACCTGATCCCGCCGGCGATCGAGGA







:::::::::::::Rv291T7.seq:::::::::::::







CGACGCTGGGCCCAACTGCGACCACCAGGTCCTGGTATGGCAGGACATGGCCGGGTTCAGCGGCGCCAATACCG




(SEQ ID NO. 360)






Clone Rv292




:::::::::::::Rv292SP6.seq:::::::::::::







TAACGACTCGGGTCCAGCGACCGCGCCAACACNAACGGCCGGACNACGTGGGCCAGGGTCGCGGCCTCCCCTACAAACAGGATCCGTTGCCTGCGAACGACAGGCT




(SEQ ID NO. 361)







CCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGCTTGTTTCCTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTACCC







GCAGGCAACCTCCCAAAAATGCAATCCCCCAAAATGCAATGCGTCNAGCTATTTCTCACACCGACCGCTAGTTGCGGATCANAAATCCGTTGGGCGCGGA







:::::::::::::Rv292T7.seq:::::::::::::







CNTGGCGGTGGGTGCGGTGTCGAACACGACCACACTTCTTTGCGGTTCGGTGATCTCGACACCGGCCGCGAGCCGACCACCATGCGCGCGTAGATCGGCGATCAGC




(SEQ ID NO. 362)







GCGTCGGCTATCGCCTGGGTGCCGCCCACCGGAATCGGCCAGCCGACCGAATGGGCCAGCGTTGCCATCATCAGTCCGGCGCCGGCCGACACCAGTGACGGCAACG







GTGAAATCNCGTGGGCGGCAACGCCGGTGAACAACGCGCGGGCATCCTCGCCCGCCAGCGACCGCCAGGCAGGGGTGCCCTGGGCCAGCATCCGCAGCCCGAGACN







CAGGACCGANCCCAGTG






Clone Rv293




:::::::::::::Rv293SP6.seq:::::::::::::







GCTTTTCNGATCGCAGCGAGTCGTACCCGCGCCGGTCACCTTCGTGGATATCGCCGGCCTGGTCAAGGGGGCGTCCGAGGGAGCCGGGCTGGGTAACAAGTTCCTG




(SEQ ID NO. 363)







GCTCATATCCGCGAATGCNACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCAACAACNACTTGACTCATGTCACCGGACGGGTCGATCCCCANTCCGACATTGAGG







TCGTCGANACCGAGCTGATCCTGGCANATCTGCAAACCCTGGAGCGGGCCACGGGCCGGCTGGAGAAGGAANCGCGCACCAACAAGGCGCGCAAGCCGGTCTACGA







CGCGGCACTGCGTGCCCAGCAGGTGCTCGACGCCGGCAANACGCTGTTCGCCGCGGGGGTGGATGCCG







:::::::::::::Rv293T7.seq:::::::::::::







GTCGTACGCCATTNGTCGGTGTGCGCATACCAGTACGACGCGCCGGGCACCTGACGCGGCGGCCGCGACCAGTCGGTGGCCATCGCCATCGTCTGCCACCCGGTCA




(SEQ ID NO. 364)







ACGGACGCACCTTCTCCTGGCCGACGTAGTGCGCCCACCCGCCGCCGTTGCGTCCCATCNATCCGGTCAACATGAGCAGCGCCAACACCGAGCGGTACATGACATC







GCTGTGGAACCAGTGACAGATTCCGCCGCCCATGATGATCATCGACCGTCCTCCGGATTCGGTCGCGTTGCGGGCGAAATTCCTTGGCAAACCGGATTGCCTGCGC







GGCCGGCACACCGGTGATCGACTCCTGCCAGGCCGGGGTGTTCTGCTGGGTTCGGTCGTGGTACCGGT






Clone Rv294




:::::::::::::Rv294SP6.seq:::::::::::::







GCGAGGCGGTATCGCTTCCCGTCGTACCGGCGACCGCCAGCCGAGAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGCNTGCGTGCCANACCG




(SEQ ID NO. 365)







CTTCCGCTTCGGGTTACAACGAGCCGCGGGGCTACGATCGTGCGACGCTGAANTTGGTGTTCTCCATGGACTTGGGGATGTGCCTGAACCGGTTCACCTACNACTC







CAAGCTGGCGCCGTCTCGTCCGCAGGTCGTTGCTTGCGATAGCCGGGAGGCCCGGATCCGCAATGACGGATTCCATGCCAACGCTCCGAGTTGCATGCGGATCGAA







TACNAATTGATCACCCA







:::::::::::::Rv294T7.seq:::::::::::::







TGGGTCTTGCCGGCGAGCCCAGCGAAGTCGCTAGCGTGGCCGTGTTTCTTGGCTTCGGATCTATCCTCGTTACATGACCGGCACCGTGTTGGACGTGACTGGCGGC




(SEQ ID NO. 366)







CGGTTCATATGACACCGAGATCATTGCCACGGTACGGCAATTCGTCAAGAAGGAAATCTTTCCCNATGCACCGGCCCTCGAACGTGGCAACAGCTACCCGCAAGAA







ATCGTCGATCGGCTGGGTGTTATTGGCTTGCTCGGTCGCCGGCTGCAAGGGTATCGACACCACCGAGTTCATTCTCGGGCGTGCCGGCGCATTCGAGCTGGCGGTG







CGCGCTGCCCAGCACCGTCATAAGTACTTGANGATGGTCAAACGTCGGACGAACCGCCACCACGTCGCTGCCGAACGG






Clone Rv295




:::::::::::::Rv295SP6.seq:::::::::::::







TAGATGCCCAAGCTTGCCNTTANAGACCTCGTCGACCAAGCACGGACGCGACCGTCGAAGGTGGCGAATCCGGGCTTGGCGTCNACCCGCGTAAGGCAGACCAGAT




(SEQ ID NO. 367)







GGTTCGCGGCACGGTCAACCTGCCACACGGCACTGGTAAGACTGCCCGCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGCGGAT







GTTGTCGGGAGTGACGATCTGATCGAGAGGATTCAGGGCGGCTGGCTGGA







:::::::::::::Rv295T7.seq:::::::::::::







TCTCCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCTGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGA




(SEQ ID NO. 368)







AAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTTGGC







GTTGACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTNGGTAATCCGGCC






Clone Rv296




:::::::::::::Rv296SP6.seq:::::::::::::







GCCCGGTTCGATCGGGCATGTCCGCAGTCGTCGTTACCGGAGGCGGTCGTGGCCGCGCTAATCGGCGTCGGCGCCGACAAGATGTGGGATATCCGCAATCGGGGCG




(SEQ ID NO. 369)







TCATCCCTGCGGGCGCGCTCCCCCGCGTCCGAGCCTTCGTCGACGCAATCGAGGCAAGTCACGACGCGGATGAGGGGCAGCAGTGAATTACAGCGAGGTCGAGCTG







TTGAGTCGCGCTCATCAACTGTTCGCCGGAAACAGTCGGCGACCGGGGTTGGATGCGGGCACCACACCCTACGGGGGATCTGCTGTCTCGGGCTGCCGACCTGAAT







GTNGGTGCGGGCANCGCCGGTATCNACTCCCGTGGAACACAGCCGGGGC







:::::::::::::Rv296T7.seq:::::::::::::







CTCGGCGTGGATATCGGTGTAGCCGGCGCCGGTGAANGTCGGCTCCTTACGTCCACTCGACAACAGCTCATAGCGATCCAACCAGTANGCAACCGCCTTCAGCAGT




(SEQ ID NO. 370)







ACAACCGCGCCGGCGAACACTGCGAGTTGAACGCGAGCTGCCTGGGTCAGCATGCCTCTGCCGGTTGTCAGCCGAAGGCCGCCGAACAGGTAATGCGTCAACAGGC







TCGCTAGAAACGCCAGAACCACGGCCACGAACAGCCAGTTCAGCACCGACCGGTAGAACGGCAGATCGAAGACGAAAAAACCCAATGTCATAGCCGAATTCGGGGT







CCACGATGCCAAAGGTGCCCCCGTGTACAACAACTGAACCTTCACCCA






Clone Rv29




:::::::::::::Rv29SP6.seq:::::::::::::







TCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTC




(SEQ ID NO. 371)







AAGCTTCACGTCCGTACGGCTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGT







TGCTCACCGGAATCCAACCGGTAGAAGGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGC







AGGCTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTAGACGGTTCCTTTCCTAAGCAACACCGAAGT







TTCAGGACCGAATGCTCCGGGAAACATGTCA







:::::::::::::Rv29T7.seq:::::::::::::







CAGGCATGCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACGCCCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGA




(SEQ ID NO. 372)







TGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTCCATCCGCTCGGCCGCCAGTGTCCGGGCCCTC






Clone Rv2




:::::::::::::Rv2SP6.seq:::::::::::::







CCTGCATCCGGCTCGTATGTTGTGTGGAATTGTGANCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGA




(SEQ ID NO. 373)







ATACTCAAGCTTCCAATCCCCCTGCCCTGATACGCGTCGGCAACCGTGAACGCGATCTCGGCGACCGTCGGATCGGTTTCATCCCGCACAAAACGCGCGTCGGCTA







CGGGGTCGCTTCCGTCGGTCACCACCCAGACGAAGTGGTCGACGTAGTCGACTTCCGACAGGTAGTGCATCAACGCCGGACTGGGAACACNAGCCGACATGAACCG







TCGATACAGCGTCTCNCCGGAGAACTGGATGTGTCCGTGCACGGTCCGCTCGCGGTCACCGGGCAGCACGGGGCGTAACATCAGTTGAGTCCCGTCGGCAAGCCGT







ACCGGAATCGGGGAGACGA







:::::::::::::Rv2T7.seq:::::::::::::







CAAGATGATCGCCGGTGCCACCCCGATCCGTGCCTCGGTCAGCGCGAACGTGCTTTCCGGTCCGGCGACCACCATGTCGCACGCACCGACCAGGCCGAACCCGCCG




(SEQ ID NO. 374)







GCCCGCACATGCCCGTTGATGGCGCCGACCACCGGCAGCGGCGACTCGACGATGGCGCGCAACAGCGCCGTCATTTCCCGCGCCCGCGCCACCGCCATCCGGTACG







GATCACCACCACCACCGCCGGCCTCGCTGAGGTCCGCGCCGGCGCAGAACGTTCCGCCGGTATGCCCCAGCACGACCAGCCGCACCGCCGGATCTGCTTCGGCCGC







ACTCAGCCCTTGATGTAGTTGGCTGACCAGCGTGCTCGACAGCGCGTTGCGGTTGTGCGGAGAGTTCAGTGTCAGCCTGGCGAAGGGGCCGCCGCAGGCGGCCGGG







CCAGCGTAGTCGACGGGGCTG






Clone Rv301




:::::::::::::Rv301SP6.seq:::::::::::::







CTCAAGCTTCGATCGACAGTACTCCCGCCTTGGGTCTGGTCTTCGAGCTGGTCGGTCATGGTCGGACCTGCTGGTAGTGGGGATCTAACGCAACATGGTCGGGATT




(SEQ ID NO. 375)







CATCATGGTGTACCCGTGATACCCATTCGCAGCTGCCGGTGAAACCCCGCGATGCCGGGATTTCCAGCCGCACTAGGATGTCTAGCCGGCCAGCCGCTGCCGCCGG







ACTTCGGGATGTTCGGTATACCACCGATCGGCAATCTTGCNTATCCGCCGATGCTCGAACGCTAGCCACCCCAAACCAACCACTGTGACNACAATC







:::::::::::::Rv301T7.seq:::::::::::::







TGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCGGATTGGCCCTGCCGCTGCAGCAGACCATCGACGCC




(SEQ ID NO. 376)







ATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTCCACTATCAACGGAATTTCGATGTCGGAGGTCGTGC







CGATCGATGTGTCCGTCGACATTCCGG






Clone Rv302




:::::::::::::Rv302SP6.seq:::::::::::::







TACTCAAGCTTGAACGCTGCGAGCGAGCCCATGTAGAGCGTTTGGTACCAAACCGATCGGTGGGCCAACTTGCCATGGGCTCACAGCGGCTATCGCGAGCGTGTAG




(SEQ ID NO. 377)







CCGATCATCGGCCAGGCGACGGTGGCCTGAGCGGCAGGGGTTGCCTTATCCATCCTCTTGCGGCATGGTTGCCGCAGGGAGTGCCGGTAAGTCTGGTCGGCAACCT







GGCCCGCTGCGGGTTGGGTTCGGATTCCCTCGGCTAGTAAGGTGCTCGCCTGGTGTTACAACGAATCGCTAGACAGCTCTTATCGGGAGTGGCCGTCGCGATCGTT







GCGCTGCCGCTGGCGATCGCGTTCGGCNTTACCGCCACCGGAACGTCCCAAGGTGCGCTCATCGGGCTCTACGGCGCCATCTTCGCCGGATTCTTCCCNGCCGTGT







TCGGTGG







:::::::::::::Rv302T7.seq:::::::::::::







GCGGTGTCTGAACTTCGCCCGTTCCCTCCAGCGCATTGAGCTTCAGCCCGACCGGCAGGTAGGGAGTCGGCATGCGGTCCTTCGCCCCGACCCCGCTGGCTAAATA




(SEQ ID NO. 378)







GCCACCCCCGAGCGCGGTCACGGTCTTTGCACCGGGACGACGGCATACCGGCAGCGCGAACATCGCCGCGGGCTGCAGCGTGAACGTCGAATACGAGTCGAACAGT







GTCGGCGCGTAAAAACCCGAGCCGGCGGTCGCTTCGGTAATCAACGGCTCCTGCGCAACCAGCTGCAANTCNCCGGTGCCACCGGCGTTGACAATCTTGATNTCGG







CGACCTCGCGCACCAN






Clone Rv303




:::::::::::::Rv303SP6.seq:::::::::::::







TACTCAGCTTCGGCTCAGGTGGTGCTGCTGGTAAAGTTCNCTGAACGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGGTACTGCCATCGAGACACTGGCGC




(SEQ ID NO. 379)







AGGCTATCGCACCCGTTATCGGCTACAAACAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGAT







CGCCGTCAAGCNTGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCNTGTTTGGTCNCGATGCCTGGCGCCCGGCCGGCGT







:::::::::::::Rv303T7.seq:::::::::::::







CATCACCTGGTTCATGAAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGC




(SEQ ID NO. 380)







CGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACANCGCGTTCTC







CACCGACCGGGCCCGGGTGTGGGGTGTT






Clone Rv304




:::::::::::::Rv304SP6.seq:::::::::::::







CTCAAGCTTCCCGGCGGCCAGTACCGAAAGCGCGAACAGCTCGCGGCAGCCCACAACNTGCTGCGTCGGATTGCCGGCGGCGANATCAATTCCAGGCAGCTCCCGG




(SEQ ID NO. 381)







ACAATGCGGCTCTGCTGGCCCGCAACGAAGGACTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTG







ATGCCCGGTCGGCAAGCCCGGCAGTTGCCAAACCCAGCGTGATCAGGCTCGGCTCGCGAGTTCGGCGAAGAAGTGGCTCGCCTGATCACCTACCATCGGCCAGGAT







CTGCGTGTCATCACNACGCTCGCCAAGGAGGTTGTTGTGGTGCT







:::::::::::::Rv304T7.seq:::::::::::::







GCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTAATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACGACGCT




(SEQ ID NO. 382)







GATTGAATCGAGTTCCAGGTCCAGCGGGTGGCGCAGCAACGGCGCGAGCTCAACGACGTCAATCACGTTGTCGCTTTCTACGGTCACCGACCCGGTGACCGTAGTC







GCCCGGTGCGCTCGGCCGAGAAGTTGCACCGCCACCACCGCGACACCGTCTTGCACGCGGACGCCACCCCCGGATCGGTTGTTGGCCAAGGTAATTGGGTCATTCC







ATTTGACGGGACGCCGACCCCGCAGCCCCAGTACCGCCCACGACCACGCCGGCTGACCCCACCACTGTACGAACACCAAGGCGACGCCGACCA






Clone Rv306




:::::::::::::Rv306SP6.seq:::::::::::::







CTCAAGCTTGATGCCGCCTAAACCGAAGCGTGAGCACGCCGCCACCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGATGGCA




(SEQ ID NO. 383)







CGCCACCGCGACACCACCCGGCTGCGCTACGTCAAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCNAGGTCNATA







CCGATTTGCGCATCCGCAGCCGCACCCTGGACGACAGAACCGTGCCCTACGAGTGCTTGTCGGGCGGGGCCAAAGAACANCTTGGCATCCTGGCGCGATTGGCCGG







CGCGGTCCTGGTC







:::::::::::::Rv306T7.seq:::::::::::::







CTCGGGTACGCTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACC




(SEQ ID NO. 384)







GGTANAANGTCGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTCGGGGTGGTC







GCGACNCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCG






Clone Rv307




:::::::::::::Rv307SP6.seq:::::::::::::







CTCAAGCTTCAATTCCTCCACGACGCGTTCCCAAATGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCG




(SEQ ID NO. 385)







GATTGGCCCTGCCGCTGCAGCAAACCATCGACGCCATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTC







CACTATCAACGGAATTTCGATGTCGGAGGTCGTGCCGATCGATNTNTCCGTCNACATTCCGGNGGTCACCATCACCGGCACCAGNATCGACCCGATTCCGCTGAAC







TTCGACGTTCTCAGCAGCGCCGGAACCA







:::::::::::::Rv307T7.seq:::::::::::::







TTAACCCCCGTGGCCTCTACGCCGCCTNCGGGTCGAACATGCATCCCGAGCANATGCTCGAGCGCGCACCCCACTCGCCGATGGCCGGAACCGGCTGGTTACCCGG




(SEQ ID NO. 386)







GTGGCGGCTGACGTTCGGCGGCGAGGACATCGGCTGGGAAGGGGCGCTTGCCACCGTCGTCGAAGACCCAGATTCGAAGGTGTTCGTCGTGCTCTACGACATGACC







CCGGCGGACGAGAAGAACCTTGACCGGTGGGAAGGCTCCGAGTTCGGCATCCACCANAAGATCCGATGCCGCGTT






Clone Rv308




:::::::::::::Rv308SP6.seq:::::::::::::







CTCAAGCTTGATTTTGATCATCATGGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGGCT




(SEQ ID NO. 387)







TTCCGTATTGGTCTGGCAGGACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTG







CTGATTTCCCGGTTGAAAAANGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTTCG







CCGTTACCATGTCGTTGTTTGTGTTCAGCGATTTGCGAATTATTGGTCAGAT







:::::::::::::Rv308T7.seq:::::::::::::







CGNCCAACCCGAATTGGTTTTCGGCGCCNTCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCG




(SEQ ID NO. 388)







GTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCNCNGGCGTTACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACG







GCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCANACGACATCGTGGC







GAGATTCGCCGG






Clone Rv309




:::::::::::::Rv309SP6.seq:::::::::::::







CGTGACTGCCACCGGGGCCACTCCGCAGAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTG




(SEQ ID NO. 389)







TCNACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACNCAGCGGTTCCNCTGACCAATACGGTCGGTC







CCACGATGACCCANTACTACNTCATTCGCACGGANAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACC







AAACTTGAAGGTGATTGTTAACCTGGGG







:::::::::::::Rv309T7.seq:::::::::::::







TCGCTCAAGCGCNTGAGGCCGAANCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCGATGCTGGA




(SEQ ID NO. 390)







GGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGACCCTGCTGGCAAAGATC







ATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAACACCGCCAGCTCGGCTTCGAGTTCGGCACTTTCA







GTGACCGGTTCAACCGGCTCGAAAAGGCGCTACANAT






Clone Rv30




:::::::::::::Rv30SP6.seq:::::::::::::







ATACTCAAGCTTCCGCTGGGGCCTGTTCAACCATGGCGATCCCGTTGGTCCCGGACATCCCGAACGAGGACACCGCGACCCNCTTCGGTGTGTGATCATTACCGTT




(SEQ ID NO. 391)







GGGCCACTGCGTAACCGCTTGCGGCACAAAGAGCCCGGTCTCGACGTCGGAAAGCTCATCGGGCACCCGATTGAAATGCAGCAGCGGCGGCACCACCCCGTGCCGC







AGTGACAGAATTGCCTTGATCAGCCCGACGGTCCCCGCCGATGCCGTGCTGTGCCCCATGTTGCTCTTGGCCGATCCAAGCGCGCAGGGGGTGCCCGCGCCATACA







CCCGCGCCAGGCTGCGGTACTCAATCGGGTCGCCGATTGGCGTACCGGTGCCGTGCGCCTCCACCACACCGACCGTTTCGGGCTG







:::::::::::::Rv30T7PEG.seq:::::::::::::







CAACAGCGTTCCAGCGGCATACCACCGCACATGCCGTGCACCCGGCGCCGGGCGGAGTCGCCGCATAACACANGTACACCTTGGGAATCGGTGTGCGCCAGGGATT




(SEQ ID NO. 392)







CNACCGCGGGGTGGGGCCGGCGATCGCGCGCCAGGTCGAGTTGGCGCCGACCGTGATNTCACCGCCGACGTAGTTGGCGTTGTGGTCCGCCATCCGCGCGGCGGGC







ACGGCGCGGGCCGCCACCACGATGTCACGGAAGCCGGGGGCGAACGCTCGACGACCTGGTTACCGTCTCNGTCGCNTCNANCGTGGACCCGACNGCACGTGGGCAT







ATGTCCANAACGGACGNGGCCGGTTTCNTCGATGCNGCCGGGGTCCGCGACNTGCGGACNCNCNGNCACACCATCCGCCAGTCCGCGTGGCGTCCCGCCGCGACTC







TGCCTCGGCCGCGCCA






Clone Rv310




:::::::::::::Rv310SP6.seq:::::::::::::







CTCAAGCTTTGNCGACGATCGGGCGATGTCGATGANAGGAAACCCCAGCGCACAACCGACNATTTTGGCGTAGCCGGCGGACNTCTGCTCGATTCCGATCACGTCG




(SEQ ID NO. 393)







GCGCTCGCATCGAGCATGGCGCCGGCGACGGCTAGCAGCGATCCGCCGTCGTCGAGGAACACGACACGAGCCGTACGCCCGGCCGTAAGCCGCGCCCAGGATTCGG







CGAAAAACCGTTCTACGTGGCGGGTGTACTGGGTGTCCAATGATTCGTGGGGTGCGTAGGCGTCGCTGCAATCGTCGACATAAATGCCGTCGGCCCGCATCGCGTC







AACAACTCCCGGGTGAGTGGAATANCACTTGCCGA







:::::::::::::Rv310T7.seq:::::::::::::







TCCAACGCGGTGACAGATTTGTCTATCCTGGACCTGACGGTGAGGTCGAAGTTTTCCAGGAATTCGGCAAAATCGGTAAGAGCCTGAAGAATTCGGTATCGCCGGA




(SEQ ID NO. 394)







CGAAATCTGCGACGCATACGGGGCAGATACGCTTCGGGTTTACGAGATGTCGATGGGGCCGCTGGAGGCTTCACGTCCATGGGCCACAAAGGATATTATCGGCGCG







TACCGTTTTCTGCAGCGGGTGTGGCGCTTGGTCGTCGACGAGCACACCGGCGAAACTCGGGTGGCTGACGGCGTGGAACTCGACATCGATACGCTACGGGCGTTGC







ACCGCACCATCGTCGGCGTGTC






Clone Rv311




:::::::::::::Rv311SP6.seq:::::::::::::







CTCGTCCTTGACTACGCCCAGTATCGAAANCCTCCTGTGCCGGTNCGCTAAACACCCGGCGGACACTCANACGGTGCTGGTGGTGCGGCATGGCACCGCGGGCAGC




(SEQ ID NO. 395)







AAAGCGCACTTCTCCGGGGACGACAGCAAGCGACCGCTAGACAAGAGGGGTCGTGCGCAGGCAGAAGCGTTGGTACCACAGCTGCTGGCGTTCGGCGCCACCGATG







TTTATGCCGCCGACCGGGTGCGCTGCCACCANACNATGGAGCCACTCGCCGCGGAACTGAACGTGACCATACACAACGAGCCCNCCCTGACCGAAGAGTCCTACGC







CAACAACCCCAAACGCGGCCGACACCGAGTGCTGCAGATCTTCG







:::::::::::::Rv311T7.seq:::::::::::::







GTATCGCCTCCNCCTTTGGCCACCAGCAGCCACAGCGCGGTTCGCGGACCGAACGTGGACATCAATAGCCCGGAATCGGTGTGTGCAAGTTGGTAAACGGTGTTGA




(SEQ ID NO. 396)







TCCCAAGCTTTGCCAGCCTTTTCGTAGTCTTGGGCCCCACACCCCACAGTGCTTCGACGGTACGGTCACCCATGATGGCCATCCAGTTGGCATCGGTGAGCTGATA







GATGCCAGCTGGTTTCGCCAACCCGGTAGCGATCTTGGCGCGCTGCTTGTTGTCACTGATACCTATCGAGCAAGACAGCCCGGTTTGCGACAAGATGACTTTTCGG







ATCTCTTCNGCGAACTTCCAATGGGGGTCTCCGGGANT






Clone Rv312




:::::::::::::Rv312SP6.seq:::::::::::::







CTCAAGCTTTTGGTCTAGCCGGCCGAGCACGATACGGGTGTCCTTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGANGANTGCT




(SEQ ID NO. 397)







GAACCGTAGTCGAAGTGGGCGGCGTCAGACTCCACCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTG







GGGCAATGACAGGTGGCGGCGGTGCGTTCGGGTCGGCCGGCGGAGGTGCTGCGTTGGGATCNCCCGGCTGGGCATTCGGCNTNTTGGCGGCGGCCGGTGGTGGGGG







GGCAACANGTGTCCCGGTGCGGGTGGCGCTGC







:::::::::::::Rv312T7.seq:::::::::::::







ATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTA




(SEQ ID NO. 398)







CTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCAATACGGTCGGTCCCACGATGACCCAGTACTACATCATTCGC







ACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCT







ACGGCGACCCGGCCTATGGTTATTCGACCTCGCCGCC






Clone Rv313




:::::::::::::Rv313SP6.seq:::::::::::::







CTCAAGCTTGCAATGCGGGTCGGGATGCCCATGGTTGGAANATGGTCGCCCTGGCGTCNAATACGCGCGAGCGCATGAGCTCACCGGTTCGGAACAACGTATCGAA




(SEQ ID NO. 399)







AAACGTCGCACTGCTGGCAGATGGTATCTCCGATGTGGTTGTAATTTGTATCCCAACTCTAACTGTGCTATCGGATCAGCGTGAATATCGANATATTGCGAATGCG







ATGACAGGCCGCCATTCGGTTTATTCGCTTACGCTTCCCGGGTTCGATTCGTCTGATGCACTGCCGCAAAACGCGGATATGATTGTTGAAACCGTATCTAACGCAA







TTATTGATGTGGTAGGCGGCAGCTGCCGTTTTGTGCTGTCGG







:::::::::::::Rv313T7.seq:::::::::::::







CAAATACACGCCGGACGCACAGGCGGACATCGCCATCCCGAGCACACCCAAAACGGGATACAGGATGGAGGCCAACGCCACGGCCGCGCCCAGGATCACCAACCAC




(SEQ ID NO. 400)







ACCGGCTTGGTCAGCTTGTCGGCGGCGGTATAGGCATCGGGCCGCTGCAACGCAGCATGCACAAACGCGTACACCGCTGTCACCAAGACGGCGACCAGCAATACCA







GCATGACGGTACCCACGAGGTGGCTCACGCATTCAGACTATGCGGTTTGCATCCAACACG






Clone Rv314




:::::::::::::Rv314SP6.seq:::::::::::::







CTCGTCCTTCGGCCTCGCTGCAGGAGTGGGAGCCGCAGGGCTGGAAATCCGAAAAACGAGCCGGTGATCGCACTGTCGCCGATCGGCGCCGCACCTGGTTGGTGTT




(SEQ ID NO. 401)







ACGGATGAATCCGCAGCGAAATGTGGCTGCGGTGGCGTGTCGTGACTCGTTGGCGTCGACGCTGGTGGCAGCCACCGAGCGGTTGGTCCAGGATCTGGATGGGCAA







AGTTGTGCGGCCCGGCCGGTGACGGCCGATGAGCTGACCGAGGTCGACAGCGCCGTGTTGGCTGACTTGGAACCGACATGGAGTCGCCCCGGTT







:::::::::::::Rv314T7.seq:::::::::::::







GTCTAGNCCGCCGAACACGATACGGGTGTCATTGGCCACCGGCGGCGGCTGTCCGGGAAATGGCGGGTCCCCGGTGGTTTTGCTGAAGANTGCTGAACCGTAGTCG




(SEQ ID NO. 402)







AAGTGGGCGGCGTCAGACTCCACCCAGCCAGCAGGCAGCGCGAAGCTGAATCCTCCAACCGGGTTGTCGATCCGGACAGGTTGGGGTGCGTTTGGGGCAATGACAG







GTGGCGGCGGTGCGTTCGGGTCGGCCGGCGGAAGTGCTGCGTTGGGATCGCCCGGCTGGGCATTCGGCGTGTTGGCGGCGGCCGGTGG






Clone Rv315




:::::::::::::Rv315SP6.seq:::::::::::::







ACTCAAGCTTGAGATTGGCGTCAACGGGTGTCGGCACCGGCGTCCTGCAGTTGGTAGGCCTGCAGTTTGTGCATCAGGCCGATGCCGCGGCCCTCGTGGCCACGCA




(SEQ ID NO. 403)







TGTACANCACCACGCCGCGCCCCTCACGGGCGACCATCGCCAGCGCGGCGTCCAGCTGAGGCCCGCAATCGCAGCGGCGTGACCCAAACACATCGCCGGTCAAGCA







CTCCGAATGCACCCGGACCAGCACGTCG







TCACCGTCGGCGTTGGGCCCGGCGATCTCGCCGCGGACCAGCGCGACATGTTCCACGTCCTCGTAAATGCTGGTGTANCCGATGGCGCGAAACTCCCCATGACAAN







TCGGAATCCCGCGCCTCGGCGACCCCGCTCAATGTTGCTTCTCNTGCTTG







:::::::::::::Rv315T7.seq:::::::::::::







TCGACNAGCATTCTTGACNGTTGTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCGTCCGGGTATGCTGCCG




(SEQ ID NO. 404)







CCGGGATTCTCGCTGCTATTACTCCCCCCGAAGAACGCCACCGGTCCAGCGCGTGGGCCGCCGCGGTCCCCATCACAAACTGAACCCCCAACAGGGGACATGCTTA







GCGGTAGGGCGCGCGCCAAGGCGGCAGCAATCGCATCACTGCGCTGCGCGTCACTATTAACCCAGCCGGACTTCACTTCCACGACCCCGAATGGCGCCCGGTCATT







GATCATCTTGCGCACCGCGGATAATCCGGGAT







TG






Clone Rv316




:::::::::::::Rv316SP6.seq:::::::::::::







ACCGGGGCCACTCCGCACAATCTGTACCCGACCAANATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCNACCCTCA




(SEQ ID NO. 405)







ACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCNGCGGTTCCGCTGACCAATACGGTCGGTCCCACNATGAC







CCANTACTACATCATTCGCACGGANAACCTGCCGCTGCTAAAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAG







GTNATTGTTNACCTGGGCTACGGCGANCCGGCCTNTGGTTATTCCACCTCNCCGCCCAATGTTTGCNACTCCCGTTCGGGGTTGTTCCCNNAAGGTCAACCC







:::::::::::::Rv316T7.seq:::::::::::::







CGCTCAAGCGCNTGAGGCCGAANCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCGATGCTGGAG




(SEQ ID NO. 406)







GCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGACCCTGCTGGCAAAGATCA







TCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGANCTGGAACACCGCCAGCTCGGCTTCGAGTTCGGCACTTTCAG







TGACCGGTTC






Clone Rv317




:::::::::::::Rv317SP6.seq:::::::::::::







CTCAAGCTTGCGTTCGATGAAGTAGTCGTCGGTCAGCGCCGCCTCTTCGAGCTCCTTGGCGATGCCCAGCAAGGAGTCATCGCCGCCGAGCTTGGCCAGGATCTTG




(SEQ ID NO. 407)







TCGGCCTGTTCCTTGACGATGCGGGCCCGCGGATCGTAGTTCTTGTAGACACGATGACCGAAACCCATCAATTTGACCCCGGCCTCGCGGTTCTTGACCTTGCGTA







CAAACTCGCTGACGTCGTCGCCGCTGTCGCGAATGCCCTCGAGCATCTCCAGGACAGCCTGATTGGCGCCGCCATGAAGCGGACCCCATAGTGCGTTGATGCC







:::::::::::::Rv317T7.seq:::::::::::::







GGTCAGGCCGAGCAGGCGCGAGGAACGACGAACCCAACAAGCCATGGTGGTTGGCGCCGTCGAGAGGTCGGCGGTCGCCACAACGGGAAGATCGCCTTGAGCGTCG




(SEQ ID NO. 408)







CTCGACCGCCGCCTCGAGTTGGGTCATAACGAAGTAGCTGATGCCGATCATGTCGACGTTTCCGTCGCATCAGCGTGCAGCGGCGACCCACTCNACGAGGTCTCGG







TGCCGCCGCGGCCAGGGCACCAGCAGTGACGAGTCCAGGCGCCGTCGGGCCAAGCAGTCGCGGTGCCANCCGTGGTGGGTCGGGCGATGGTTGGGTGTGCTCATTT







CGGGAACGCCA






Clone Rv318




:::::::::::::Rv318SP6.seq:::::::::::::







CTCGAAGCTTTTAACAGCATCAACCCCGCCCCGCACCAGCACCGACACNATGTCGATGCCATCGAGGTGAATGTCGAACTGGCGCAAACCATCGGCGACCGCGACCA




(SEQ ID NO. 409)







CCGGCAACATGGGTACCGGCGATTTCCGGTGCCAATGCCGACCCGACGGGCCGCTCTCACCGCAGGTGACCTCGATCACCGAGACCANCCGGCCGTTNTNNTCACG







CACCCCTACCGTGTCACGCCCAAAACGGCGCTGGTGGTCGATTGCCGGAGTGCACCCCNCACCCAGTGTCGTGCCCGGATCC







:::::::::::::Rv318T7.seq:::::::::::::







TGATGCCGCACCCGATCGACGGTCGTTGGTCGGGGTTGACTGGCCGCCCGGCGAAGCAGGGCGTCGACCGCGGCCCGGACGTCGGCGGCCGTCACCGGTCGGCCAT




(SEQ ID NO. 410)







TGCCCGGGCGGGAGTCGTCGAGCTGACCACGGTAGACAAGTCGGCGCTGGCCGTCGAAGACNAACGTGTCGGGTGTGCAGGCCGCGGAGAAGGCGCGGGCGACNTC







TTGGGTTTCGTCGTANAGATACGGGAACGTCCAGCCGTGGCGGCGGGCCTCGGCGACCATCTGATCGGGCCCGTCC






Clone Rv319




:::::::::::::Rv319SP6.seq:::::::::::::







TTTCGGGCGAGGCGGTATANCTTCCCNTCGTACCGGCGACCGCCAGCCGANAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGANTGCGTGCC




(SEQ ID NO. 411)







AAACCGCTTCCGCTTCGGGTTACAACGAGCCGCGGGGCTACNATCGTGCGACGCTGAAGTTGGTGTTCTCCATGGACTTGGGGATGTGCCTGAACCGGTTCACCTA







CNACTCCAAGCTGGCGCCGTCTCGTCCGCAGGTCGTTGCTTGCGATAGCCGGGAGGCCCGGATCCGCAATGACGGATTCCNTGCCANCGCTCCGAGTTGCNTGCGG







ATCGACTACNAATTGATCACCCANAACCATCGGGCGTNTTACTGCCTGAAGTACCTGGTGCGGGTCGGATACTGCTATCCGGCGGTGACAACCCCGGCAAGC







:::::::::::::Rv319T7.seq:::::::::::::







GTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCGTCCGGGTATGCTGCCGCCGGGATTCTCGCTGCTATTAC




(SEQ ID NO. 412)







TCCCCCCGAAGAACGCCACCGGTCCAGCGCGTGGGCCGCCGCGGTCCCCATCACAAACTGAACCCCCAACAGGGACATGCTTAGCGGTAGGGCGCGCGCCAAGGCG







GCAGCAATCGCATCACTGCGCTGCGCGTCACTATTAACCCACCCGGACTTCACTTCCACGACCCCGAATGGCGCCCGGTCATTGATCATCTTGCGCACCGCGGATA







ATCCGGGATTGCCAGCCCATTCNACTACCGCATGCGAGTCATCGGCTGACCGCAGCGGTC






Clone Rv31




:::::::::::::Rv31SP6.seq:::::::::::::







TCGCCTAGGCGGGCTTCCCCTTCCGTCCGAGCNGTCAGAAGCTCCTATGACAATGCACTACCCGAGACNATCAACGGCCTATGCAATACCNAGCTGATCAAACCCG




(SEQ ID NO. 413)







GCAAGCCCTGGCGGTCCATCGAGGATGTCGAGTTGGCCACCGCGCGCTGGGTCGACTGGTTCAACCATCGCCGCCTCTACCGGTACTGCGGCGACATCCCGCCGGT







CTAACTCGACGCCGCCTCACTACGCTCAACGCCAGAGACCANCCGCCGGCTGACGTCTCAGATCAGAGAGTCTCCGGACTCACCGGGGCGGTTCATCCCCACTGTC







GATAGCGTCTGTGGATAACTTTGTCTGCA







:::::::::::::Rv31T7.seq::::::::::::::







GCGCGTNGAACTGATAGGTGCGGCCCGGCTCGAGCANGCCGGCCATTTGTTCGATGCGGTTACCGAAGATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGC




(SEQ ID NO. 414)







CCAGTGCCCGGCGTTGGCCGCCGCGGCGACAATCTTGGCGTCCACGGTGGTCTGGGTCA






Clone Rv321




:::::::::::::Rv321SP6.seq:::::::::::::







CTCAAGCTTCAATACAGAGTTATAAACTGTGATAATCAACCCTCATCAATGATGACNAACTAACCCCCGATATCAGGTCACATGACGAAGGGAAAGAGAAGGAAAT




(SEQ ID NO. 415)







CAACTGTGACAAACTGCCCTCAAATTTGGCTTCCTTAAAAATTACAGTTCAAAAAGTATGAGAAAATCCATGCAGGCTGAAGGAAACAGCAATAACTGTGACAAAT







TACCCTCAGTAGGTCAGAACAAATGTGACGAACCACCCTCAAATCTGTGACAGATAACCCTCAGACTATCCTGTCGTCATGGAAGTGATATCGCGGAAGGAAAAT






Clone Rv322




:::::::::::::Rv322SP6.seq:::::::::::::







CTCAAGCTTCGATCGACATTACTCCCGCCTTGGGTCTGGTCTCCGAGCTGGTCGGTCATGGTCGGACCTGCTGGTAGTGGGGATCTAACGCAACATGGTCGGGATT




(SEQ ID NO. 416)







CATCATGGTGTACCCGTGATACCCATTCGCAGCTGCCGGTGAAACCCCGCGATGCCGGGATTTCCAGCCGCACTAGGATGTCTAGCCGGCCAGCCGCTGCCGCCGG







ACTTCGGGATGTTCGGTATACCANCGATCGGCAATCTTGCGTATCCGCCGATGCTCGAACGCTANCCACGCCAAACCAACCACTGTGACNACAATCGCCACCACAC







CAAAGGTCATGCCCTCGGCGTGATGTCCGGTGCCGAAAGCCGCAAGAGCTCCGACGCCGCC







:::::::::::::Rv322T7.seq:::::::::::::







CATTCCCAATTGAATTTCCCNATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGCAACGCTGGGCGGATTGGCCCTGCCGCTGCAGCANAC




(SEQ ID NO. 417)







CATCGACGCCATCGAATTGCCGGCAATCTCGTTCAGCCAATCCATACCCATCGACATTCCGCCGATCGACATCCCGGCCTCCACTATCAACGGAATTTCGATGTCG







GAGGTCGTGCCGATCGATGTGTCCGTCGACATTCCGGCGGTCACCATCACCGGCACCAGGATCGACCCGATTCCGCTGAACTTCGACGTTCTCAGCAGCGCCGGAC







CCATCAACATCTCGATCATCGACATTCCGGCGCTGCCGGGCTTTGGCAACTCGACCGAGCTGCCGTCGTCGGGCTTCTTCAACACCGGCGGCGGTGGCGGCT






Clone Rv327




:::::::::::::Rv327SP6.seq::::::::::::::







CTCAAGCTTTCGGCGGAGACGGACANNTTGCGAACATTGATGACAAAATAGAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTC




(SEQ ID NO. 418)







CAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCCGTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGC







GAAAAACGGTCGCCGTTGCACGACATTAAATGTCACGGTATTG







:::::::::::::Rv327T7.seq:::::::::::::







AGCTTAACTGCTCCCTAATACCTGGGGCTGTGCCTGCGGTGTATGCACGGCATACGGACATCCNTCCCCTGAGACCCNCGGTCTAATCAGCCACGTGTCCACCATC




(SEQ ID NO. 419)







AGGGGTCAACCCCGGCCAAGGGCGACGGCACCCCAAGTTCGCCGACCGTTAACCTATTGCTGTGAGCTTCATTTGCTGCGAGCAAAACAGTTGGTCGGCCGTTAGG







AACTGAATTGACACTCAACCGATTTGGTGCCNCCGTAGGTGTCCTGGCTGCGGGTGCGCTGGTGTTGTCCGCGTGTGGTAACGACCACAATGTGACCGGGGGAGGT







GCAACCACTGGCCACGCGTCCGCGAATGTCTATTGCGGGGG






Clone Rv328




:::::::::::::Rv328SP6.seq:::::::::::::







CTCAAGCTTGGGGTGGCGCTGTCGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGTCCA




(SEQ ID NO. 420)







AAATCACCCTCGCCCAGACCTGCTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGGGTGTCCACACCGGAGGACCCGGCGTCGGCGCGGTTCGG







CGAAACGTTGTGGGAGTTCCTGCCCCGCAGTGTTATCGGCGGCTTGCGCTCGGCCGTTCATTTGGAGGCCCAACGGCTGCGTCGGCTCGGCGTCAGCCCCCT







:::::::::::::Rv328T7.seq:::::::::::::







GCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTACCACCTGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAA




(SEQ ID NO. 421)







CAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCNATCCATTCGAGGTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCAG







GTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGGTGTGGACGAAACAGATCTTCTGTCCGA






Clone Rv329




:::::::::::::Rv329SP6.seq:::::::::::::







TCGCCTCCGCATATGGGTCGACGCCAAGCGGGTCCGGATTTCTGGGCTTCATCGCTCGCGCCGTCGCGACAAACAGCGCGGTCGAACCGACACTCGTTGTGATGTC




(SEQ ID NO. 422)







CCAGCTATCACCTTCGGTACGCACCCAATCGACCCTACNCGGCTATCTCAGCCGCGATCTCCAGGCTCCGCCGAGCCAGGTGCATCCCGGTCCGGATCCCACTAAC







CCGGCACCATTGGCGTCN







:::::::::::::Rv329T7.seq:::::::::::::







GTCCTCGAGTGCCGCCGTCGNCACNCCCAGCGCCCGCGCGGCCACTTGGATGCGACCCGTTTCAAGTCCCTTCATCATCTGCGAAAAGCCTTGACCCATGGCTCCG




(SEQ ID NO. 423)







CCCAGGATCGCCGAGACCGGCACCCGGAGGTTGTCGAACGACAGCTCGCAGGATTCGACGCCCTTGTAACCCAACTTCGGCAAGTCCCGCGACACCGTGAGTCCCG







GCCCGGGTTCGACGAGCACGATCGACATGCCTTGGTGCCGCGGTGTGGCGTTCGGGTCGG






Clone Rv32




:::::::::::::Rv32SP6.seq:::::::::::::







GGCATACCAATGTGGACTTCTGCTCACCCACGATATCCGTGGTCTGATCCGCTGCTGCGGCGGGCTGCNACCTGCNTCTCNGCGGCACCCGTNACTACATGGCNCG




(SEQ ID NO. 424)







CGCCGCACGCATACGTCGCGGCGGGACCCACTCCNACTGGTCGACGGTGCTGGCCGCGTGTCCGCANGTCCCNAACCCGGCCGCACCGACGAAACCGGCCGCCGTC







CGTTCTGGACCAACGCTCATGTGCCGTCGGGGTCCATGCTCGACGCCATCGAGACCGTAACCAGCGTCCTCGAGCGGTTCGCCTCCGGCTTCCGTGACATCTTCGT







GGCTGCTCGCGCCGTGCCGCCGCGCGGATGGTCGACCACAACGCCAACCACCTCGGCGGTGACATCACCGTCCGCGCCACTCGACCTGGCGCGCGATCGCGGCCC







:::::::::::::Rv32T7.seq:::::::::::::







GTGAGCAGACCTACGCCNCCTGGTTGCGCCAACTCGGTACCGATCATGGCGCGCNGCCTGTCGTCACCGATACCCAGCGAACAAGACAGCCCGGTCCGCGACAAGA




(SEQ ID NO. 425)







TGACTTTCCCGATCTCTTCGGCGACTTCCATGGGGTCGTCCGGAGTCCCGGGCGCCACCGCGAGGTAACCCTCGTCTCAGTCCCATACGCGACCGGGTATCCACGT







CGCGCAACAACGCCACCACCTCCCCAGACGCCNCGTTGTACGCGGCTGGGTTCCACNGCAATAAGTGGCCTCANGGCATCGTCCGGCGGCGGTCCNCAACGCA






Clone Rv330




:::::::::::::Rv330SP6.seq:::::::::::::







CTCAAGCTTGAGGTTAACTTTGAACGGATCGAGCTGGACGTTCGAGACGGTGATCGGGCCGAACCTGAATTGTCCGGTAATGCCCAACGCAAAAAGCAGGGTGGTG




(SEQ ID NO. 426)







GCCGGGGCGGTGAAACCGGCGTCGGCGGCACCGTCGAAATCTATGTGGATTGCCGGAATGGGGATGTCCGGCACGGCGAAACCGTAGTTCGCTTGTCCCGTGAGGC







CCAGGTGGATGGGGGGAAAGATCCTGGTGTCCGGGATAATAATGGGGCCGATGCCGCCGGTTGAAGTCCACTGGATCGGGAATTCCGGAATCTTGATCCGACGTTC







AGGCCGAACAGGCCCTC







:::::::::::::Rv330T7.seq:::::::::::::







CGGCGACGTCGCGATACGCCGAGCAGTTGGGAATCGCTCTGCAGCAAACCAATATTCTGCGCGACGTTCGAGAGGACTTTTTGAATGGACGGATCTACCTGCCGCG




(SEQ ID NO. 427)







CGACGAGCTGGACCGATTAGGCGTACGCCTCCGCCTGGACGACACCGGGGCACTCGATGACCCCGACGGACGGCTCGCGGCNCTGCTGCGGTTCAGTGCCGACCGC







GCCGCAGACTGGTNTTCGCTGGGACTGCGGCTGATTCCACACCTCGACCGCCGCAGCGCTGCCTGCTGTGCGGCCATGTCTGGCATCTACCGCCGTCAGCTCGCCT







TGATCAGAGCATCGCCGGCGGTCGTCTA






Clone Rv331




:::::::::::::Rv331SP6.seq:::::::::::::







CTATAAAATACTCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCG




(SEQ ID NO. 428)







GTGATGGCACGCCACCGCGACACCACCCGGNTGCGCTACGTCNAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCN







AGGTCNATACCGATTTGCGCATCCGCAGCCGCACCCTGAACNACANAACCGTGCCCTACTATTGCTTGTCNGGCGGGGCCAAAAAACAGCTTGGCATCCTGGCCCN







ATTGGCCGGCGCGG







:::::::::::::Rv331T7.seq:::::::::::::







CTTCGGTCGCAGTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGCTCACCGGAATCCAACCGGTAGAAGGT




(SEQ ID NO. 429)







CGGCGAGCGCTCGGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCAGAGCCCTCGGGTCCGGCCAGCACTCCGCAGGCTTCGTCGGGGTGGTCGCGACGCGCA







TGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCNCCANCACGTANACNGTTCCTTTCCTAA






Clone Rv333




:::::::::::::Rv333SP6.seq:::::::::::::







CTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGCCGTTACCACCGAACGGGCGAGCCGGGAGTCTGGTNCGCATCG




(SEQ ID NO. 430)







AACAAANAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCNATCCATTCGAGGTCCGTCGCCGCGTCGGTCNAGTGGCGGTCACACTCC







AGGTACTCGACCTCACAGACNAAAGGACTCNATCCCATCTAGGTGTGGACNAAACAGATCTTCTGTCCGACNACTACACCACCACCCAGGCCATCGCCGCCGCCCG







CGATGCCAACTTCGACGCCGTACTGGCCCCGGCGGGGGGCGCTCCCCGGTTGTCAACACTTGCCGTGTTCNTTCACGCNCTGCCCCACATCCAACCCCAACG






Clone Rv334




:::::::::::::Rv334T7.seq:::::::::::::







GTTCTTGGGCCCATGCGGAGGTATCGCCGTTTCCACCACGCGGTCGGGGTGGCGTTGCATTAGCTCACCGATGGTGCGCTTGTGCAGGCCGCCGGGATACCCCGAG




(SEQ ID NO. 431)







TGCCGGTAAACCATCTTGTGCTGC






Clone Rv335




:::::::::::::Rv335SP6.seq:::::::::::::







CAATACTCAAGCTTGGCGTGCCGTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACNAGNACGTCGTCCGCGGGACACACCT




(SEQ ID NO. 432)







CGATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGG







ATC







:::::::::::::Rv335T7.seq:::::::::::::







CNTCATGATGATCATCACCCGAAGTGTGGTAGCCGCAGTGGTTATCGTGGGTACCGTCGTGCTTTCCATGGGCGCCTCTTTCGGGCTTTCCGTATTGGTCTGGCAG




(SEQ ID NO. 433)







GACATTCTGGGTATCGAGTTGTACTGGATGGTGTTGGCGATGTCGGTGATCCTGCTCCTGGCGGTGGGATCCGACTACAATCTGCTGCTGATTTCCCGGTTGAAAG







AGGAAATTGGGGCCGGATTGAACACCGGAATTATCCGTGCCATGGCTGGTACCGGGGGAGTGGTGACGGCTGCCGGCATGGTGTTCGCCGTTACCATGTCGTTGTT







TGTGTTCAGCGATTTGCGAATTATTGGTCAGATCGGTACCAC






Clone Rv336




:::::::::::::Rv336SP6.seq:::::::::::::







ATACTCAAGCTTTTACGGTGATCGCNCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCG




(SEQ ID NO. 434)







GGTGCAGGTGCTCGGGCAGCTCGGCCGCNACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGANNAACGACGCCAGTCCGCTACGTNACCCCTCCGCGAC







TGTCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCCGGGTGTGGGGTNTT







:::::::::::::Rv336T7.seq:::::::::::::







GCTGGTAGAGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTAC




(SEQ ID NO. 435)







GAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCATGTGTGCCGCGGAT







TATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTGGCG






Clone Rv337




:::::::::::::Rv337SP6.seq:::::::::::::







GCTTTCCGCCGATACCCGCCATGTCNCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCTACGTCGTG




(SEQ ID NO. 436)







GTGTACCTCGTCGGTAACAACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGGCCTATGTCA







CCGGTCCGGCANCACTCAATGCCGACCAGGCCGAGGCCGGANACAAAANTATCGCTAAGGTCACCGCGATCACNAGCATGGTGATCGCAGCAATGTTGCTAGTGAT







CTATCGCTCCGTAATTA







:::::::::::::Rv337T7.seq:::::::::::::







CTTCCAACCCGAATTGGCTTTCGGCGCCATCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCG




(SEQ ID NO. 437)







GTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACG







GCATCGCCACCGGAGCGACGGCCAAGGCGGCGTGCCANGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCA






Clone Rv338




:::::::::::::Rv338SP6.seq:::::::::::::







TACTCAAGCTTCGCGAGATCCGGATGGCACTCACGCTGGACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACTC




(SEQ ID NO. 438)







GTTCGGCGTGCAGGACGCGGCGCAAACGTNCTTCGGCATCAACGCGTCCGANCTGAATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCNACCAGCACG







CTCAACCCGTA







:::::::::::::Rv338T7.seq:::::::::::::







CCCACGACTTTCTCCTCGATCAGTTGGATTTGTACGAAGAGGCAACGAAAGCAGTGATCCTCGGGATGGTCGACGCCTACATCGACCCGCCGTTCACGCCGCACAG




(SEQ ID NO. 439)







CCTGCTAGATGCGCTGGGCGAGCAGGTCCCACAGTTCGCCGCTAAGGCACGGCGTCTGTTCCCGTCCGGATCGCCATTCGGCCTCGGCGTCCTGCTCCCATTCGAT







CAATAGGGCTGGCAGCTCCGTCGGCAGGGGCCTACGCCTCACCCCGTCACG






Clone Rv339




:::::::::::::Rv339SP6.seq:::::::::::::







CTCAAGCTTATGCGCGCCGGCCGAGGTCTGCTCACGGCAACCCCTGAAGTTTAGGGGACNACCTACTCAGCGCAAAATTTCGCTAATGTGAGTCCGCCCCACCAGG




(SEQ ID NO. 440)







GGNANATCAACCCATGTCGATCATGATCTACCCGGATACCGGATTGGCGGTAGCGCCCACGATCGTCNAAATNTCCGCCTGAATCATCGGATAGCTGATCCGGCGT







CAACGCGTTTTGANTTCACCGCGCAACAGCCGCCAGGCCGGCCCGCANCGANCCGATCTCNTCGGGCCGCATGGGCCCCAATCTTNTCG







:::::::::::::Rv339T7.seq:::::::::::::







GTGTGTGGTGGAACCCATCTGAGCAGTGTGCCAAACCGGGGCAGACAGCTCCCAATTGACGTGAGCCCGCTCACTTGCTGGGTAAGCGTC




(SEQ ID NO. 441)






Clone Rv33




:::::::::::::Rv33SP6.seq:::::::::::::







CTTTACACTTCCTGCATCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTG




(SEQ ID NO. 442)







ACACTATAGAATACTCAAGCTTGGGCGTGACGGCCACCGGGGCCACTCCGCACCATCTGTACCCGACCAAGATCTAC







:::::::::::::Rv33T7.seq:::::::::::::







CAGGCATGCAAGCTTTAGCTGCCCGAATGCGTCACCCCGATGCGCCCAGATCGGGGCTTCGCAGATAAAGCACGAACAGGCGGGCAAAACGTCNATCTCGGAGCCG




(SEQ ID NO. 443)







GAAGGGCAATCAGCCGACCGTCGACGAACGACACCGGCGAGACCACTTAGGCAGTGACGGCCGGCCCGAACATTACGCGCTCGTTGATTAGGCGTTCGGTCTCGTC







CGCGGTCATGCCGAGCAGCTTGCGGCAGATCTGAACGCTGTCCTGTCCGGGCAGCGGCGCCGGGCGTTGGGGTGCCTGCCCGAATGTGACGAAACGGAGCCGGACC







CGTCTCGGCGGGCCGCGGACGGCGATCCGC






Clone Rv340




:::::::::::::Rv340SP6.seq:::::::::::::







CNCAAGCTTGCGGATGTTACCCCTGACAGCCTGAACTATGTCNAAACACACGGCACCGGAACGGTGTTGGGGGACCCCATCGANTTCGAGTCGCTGGCGGCCACTT




(SEQ ID NO. 444)







ATGGCCTGGGTAAAGGCCAGGGCNANAGCCCGTGCGCATTGGGGTCGGTCAAAACCAACATCGGCCACCTGGAGGCGGCCGCCGGTGTGGCTGGATNCATCAAGGC







GGTGCTGGCGGTGCAACGTGGGCACATTCCCCGCAACTTGCACTTCACCCGGTGGAACCCGGCCATCNACGCGTCGGCNACGCGGCTGTTCGTGCCNACCNAAAAC







CCCCCGTGGCCGGCGGC







:::::::::::::Rv340T7.seq:::::::::::::







GGAACCGGTAACCAGATCAGCTCGTCGACCTCACTGCCGGGGGTGAATTCCCCACCGGTGCTGCGCGCTGCCCAGTAGTGCACCTTCTTGACGCCTCGAAAAGGGG




(SEQ ID NO. 445)







AGTCGGTCGGGTAGGTCACCGTCAGGAGCCGCCTACCCAGGTTGGCGCNATAGCCGGTCTCCTCGAGTATCTCCCGCACCGCCCCCACCGGTGCGGTCTCACCCAN







ATCCACTTTGCCCTTGGGCAGCGACCAGTCGTCGTANCNGGGGCGGTGAATGACAACGATCTCGACCGGCCCTTCCN






Clone Rv341




:::::::::::::Rv341SP6.seq:::::::::::::







TACTCAAGCTTCAGAACAGGCCTGTTGTGGGCNCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCACGCAG




(SEQ ID NO. 446)







GGCCGCGGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCGTCGCGTTCACTAATC







GCGGTGCTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGCGACCAGCTGC







:::::::::::::Rv341T7.seq:::::::::::::







TAATGTCTTGCCAACGTCACCACAATCGCGATGAATTCAATCATGCCGCCCAGGGCGGCCAACCCAATGGTGGCCGCGAGCGGCAGCTCGATCGCAGCGCGGAGGT




(SEQ ID NO. 447)







TGCCGGCCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAAGGCAAGACCTATATCTGCCGTCGGAAGAAGAATCGAGTAGCCGGT







CGACACAACGGAAGCGAAAGTGTCCGCGATGTTGATGAGCGTCGCCGGTTGTGGCGGCGGTGGCGGC






Clone Rv343




:::::::::::::Rv343SP6.seq:::::::::::::







TACTCAAGCTTTCGTCAGTTCATCGCGCCAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGC




(SEQ ID NO. 448)







GCGAACGACGCCAGCGACCACATTCAGCANATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCGACATCGTCA







CCGCCGCACCACTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGANNATCACATCGCCGCGATCGCCCTGTTC







:::::::::::::Rv343T7.seq:::::::::::::







CCACCCGTGTAATTTGGGATGGGCNAAAAGGCNAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAAC




(SEQ ID NO. 449)







GTACGGCGTTTCAACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGG







TAGTCGCCGCCCGGGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACG






Clone Rv344




:::::::::::::Rv344SP6.seq:::::::::::::







TCAAGCTTTAGCTGCCCGAATCCGTCANCCCGATGCNCCCAGATCGGGGCTTCGCANATAAAGCACNAACAGGCGGGCAAAACGTCNATCTCGGAGCCGGAAGGGC




(SEQ ID NO. 450)







AATCANCCGACCGTCNACAAACGACACCGGCGANACCACTTAGGCAGTGACGGCCGGCCCGAACATTACNCGCTCGTTGATTAGGCGTTCGGTCTCGTCCGCGGTC







ATGCCGAGCAGCTTGCGGCANATCTGAACGCTGTCCTGTCCGGGCAGCGGCGCCGGGCGTTGGGGTGCCTGCGGAATGTGACNAAACGGAGCCGGACCCNTCTCGG







CG







:::::::::::::Rv344T7.seq:::::::::::::







CCGGGGCCACTCCGCACAATCNGTACCNNACCAANATCTACACCATCGAATACGACGGCGTCGCCGANTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAA




(SEQ ID NO. 451)







CGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCGGAACAAATNGACGCNTCGGTTCCGCTGACCAATACGGTCGGTCCC






Clone Rv346




:::::::::::::Rv346SP6.seq:::::::::::::







NCTGGCCTTTGGTCCACACTAANACAATACTCAAGCTTCCGGCCGCAGAGCCGCCAACTCACGATATCGTTAACCGATATCCCGAGCCGATAGCTGGCGGGCTCGG




(SEQ ID NO. 452)







GTGGTGGCCAGCGGCGCTGCGACNAAAGGTGTGACCGTCATGAAACAGACACCACCGGCGGCCGTCGGCCGTCGTCACCTGCTCGANATCTCAGCATCCGCAGCCG







GTGTGATCGCGCTTTCGGCGTGTNGTGGGTCNCCGCCCGAGCCCGGCAAAGGCCGGCCCGACACAACCCCGGAAC







:::::::::::::Rv346T7.seq:::::::::::::







CATCTGCCCACCACACGGACCGCGGTGCGGACGCGGCTGACGCGCCTGGTGGTCAGCATCGTGGCCGGTCTGCTGTTGTATGCCAGCTTCCCGCCGCGCAACTGCT




(SEQ ID NO. 453)







GGTGGGCGGCGGTGGTTGCGCTCGCATTGCTGGCCTGGGTGCTGACCCACCGCGCGACGACACCGGTGGGTGGGCTGGGCTACGGCCTGCTATTCGGCCTGGTGTT







CTACGTCTCGTTGTTGCCGTGGATCGGCGAGCTGGTGGGCCCCGGGCCCTGGTTGGCACT






Clone Rv347




:::::::::::::Rv347SP6.seq:::::::::::::







GACAATACTCAAGCTTGACTGGCCACCCACCGGCATGACCACCGACAGGCCCGACTGGTCGTACCACTCGAACGCCGGGGTGTTGATGTCCCAGCCGCTGAANTCG




(SEQ ID NO. 454)







TCCTGCGCGCGCAGGCCGTCNAACAGGTACAGGGCGGGCGAATTGGCACCACCACTTTGGAATTGGACCTTGATGTCACGGCCCATCGACGGCGACGGCACCTGCA







GGTACTCCACCGGCAAGCCCGGCCGGGAAAATGCCCCCGCGGTCNCCGTGCCACCGACGGCGCCGANCAAACCCGACACTAGGGCCGCGCCNACGGCCCCGACCAC







NANTCNACGCGACATACCCGTGACGGCGCCACNAACCCTGTCAACA







:::::::::::::Rv347T7.seq:::::::::::::







CCTCCAACTCGGCGGGGAAGCGACNCCAGCCTACCGAGCTTGGAGTCCANGACGCCAGCGGCGGCGTCGGTCTGCGTCGTGGTGCCGCCGGGGTGGCGTTGGCTGG




(SEQ ID NO. 455)







CAACGATCTCCACCCAGCCGGTCGGGTTACCCACGATCTCGGCATANACGCGGGCCGAGGCCGGTGCGATACCGTATTGCGTCAATTGGGACGCGGTTGTGCATTC







GGCTAGCTCGGTTGCCACACCCGTCAGGGGTTCGACGTTGGCGGGTTCGGCGGGCCCCANCACCGCTGTCACCATGCCCGCCAAGCCGACCTGCGGCGCCACCAAC







TGCAGCACCANCATGTCGCCGTCGCGCGCCGCGATCACATGG






Clone Rv348




:::::::::::::Rv348SP6.seq:::::::::::::







CTCAAGCTTTTTGAGCGTCGCGCGGGGCANCTTCGCCGGCAATTCTACTANCGAGAANTCTGGCCCGATACGGATCTGACCGAANTCGCTGCGGTGCANCCCACCC




(SEQ ID NO. 456)







TCATTGGCGATGGCGCCGACNATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTTGCGGAC







GGTCCCGACGCTGGTCGCGGTTGCGCCGCNAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCNCCGCCGCGGCACTGCACGGCCAGTGCCGCGGCGA







:::::::::::::Rv348T7.seq:::::::::::::







CNCCAGCTTGATTGGTCTGGTTGCATTGGCCAGCTGCGCGAGCCTGGCTCACTTCAACTACGACGACCGCAAACAATTGCCGCCTTCGGATCCGAGTTCGGTTGGG




(SEQ ID NO. 457)







TACGCGGCAATGGAGCACCATTTCTCGGTGAATCAGACTATTCCTGAGTACTTGATCATCCACTCTGCACACGACCTGCGAACCCCGCGCGGCCTTGCCGACCTGG







AGCAGCTGGCGCAACGTGTGAGCCAGATCCCAGGCGTTGCCATGGTTCGCGGTGTGACCCGGCCAAACGGGGAAAC






Clone Rv349




:::::::::::::Rv349SP6.seq:::::::::::::







CAATACTCAAGCTTGACTGGGCCCGCACCTTCGGCGCCACCCACACCGTCAACGCCCGCGAAGTCNACGTCGTCCAGGCCATCGGCGGCCTCACGGATGGATTCGG




(SEQ ID NO. 458)







CGCGGACGTGGTGATCGACGCCGTCGGCCGACCGGAAACCTACCAGCAGGCCTTCTACGCCCGCGATCTCGCCGGAACCGTTGTGCTGGTGGGTGTTCCNACGCCC







GACATGCGCCTGGACATGCCGCTGGTCNACTTCTTCTCTCACGG







:::::::::::::Rv349T7.seq:::::::::::::







TCGACGGTTTGGCGGCCTTAAATGCACTGAGGTCGTCAATTGACCCCACAGCGGAAATGCCGACTATTCGCAGGCCTCCTTCGCCTTGGCTGCCGGAGAGGGGCTC




(SEQ ID NO. 459)







CGCGGGAACCGCATGCAGGTATATGACCTCGGTTTCTCGGGTGCTACCGCGTGCCTTGTNTANGATNANCTCGGCGTTGGAATTGTCCAGCCGGCCCAATTCATCG







AGCGCANATTCGTACACNTGGCCGGCGGCGACATACGCTTCACCGTGGATCTGCTCCACACGGACCGCCCTGTCGGGATCCTGCTCACGGGTAANGGAACTTACGT







GGCACTCGG






Clone Rv34




:::::::::::::Rv34SP6.seq:::::::::::::







GACCACGCCAGGCTAATCACGTGACGCTACCGAATACCCTNCCTAGTGGTGCAGGCTCCCGCTGGAAATGGCCCTGTACCAACTCGCGCACCGGTGCCAG




(SEQ ID NO. 460)







:::::::::::::Rv34T7.seq:::::::::::::







CGGCACCCGACCCCTTTGAGCCGTCCGCCGTGGCCGCGGTGGAACTGGCCGACGAGGGACTGATCGTGCTGGGCAAATTGGTCGATGGCACGCTGGCCGCCGATCT




(SEQ ID NO. 461)







GAAGGTCN






Clone Rv350




:::::::::::::Rv350SP6.seq:::::::::::::







CTCAAGCTTGCCGTTACCCCGACTTCCGGAGGGACACCATGAGCACCGCCAGCCGAGCACGAGGCCAAACTCCGCCGACGCAGGCCGGTTGGACTTGTCGTGCTGG




(SEQ ID NO. 462)







ACAAGGGGTTTAGCCGCCGAAGCAGTGACGTACATCGGCGAAAAGCAGTTCGCCTGTCGACCGACGGNGCNNACCGTGAGGCTAGGGAAGCGAGGAGCACATGGCC







GCCGACCCGCAATGTACACGCTGCAAGCAAACCATCGAACCCGGATGGCTATNCNTCACCGCCCATCGCCGCGGT







:::::::::::::Rv350T7.seq:::::::::::::







CATGTCGCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCTACGTCGTGGTGTACCTCGTCGGTAACA




(SEQ ID NO. 463)







ACGAAACCGAAGCGTATGACTCGGTCCACGCGGTGCGGCACATGGTGGACACCACACCGCCACCGCACGGGGTGAAGGCCTATGTCACCGGTCCGGCAGCACTCAA







TGCCGACCAGGCCGAGGCCGGAGACAAAAGTATCGCTAAGGTCACCGCGATCACGAGCATGGTGATCGCAGCAATG






Clone Rv351




:::::::::::::Rv351SP6.seq:::::::::::::







ATACTCAAGCTTCGGTACGGTGGCGGGCCGTGCTGCTGGCCGCGGTCGCGGCGTGCGCGGCCTGCGGTCTCGTTTACNAGCTCGCGCTGCTGACACTGGCGGCNAG




(SEQ ID NO. 464)







CCTGAACGGCGGCGGGATCGTGGCCACCTCCCTGATCGTCGCGGGCTACATAGCCGCGCTGGGAGCAGGCGCCTTGCTGATCAAGCCGCTACTTGCACACGCGGCC







ATCGCGTTCATCGCCGTGGAGGCGGTGCTGGGCATCATCGGCG







:::::::::::::Rv351T7.seq:::::::::::::







TGTCAAGTCCTTTCAGATCTCNTTTTTATGACATGACTGGAGATCTGTCTAGATTGCAGCTCCTGTGAGCGTGGGTACCGGATTCAAGCCGGTCGGTCACGCCGCG




(SEQ ID NO. 465)







GTGGTACCGGCTTTGCGGCAGTGCTCGGCCTCGAGTTCGGCGATCGCGCGCGAAGTGCGTTCGCGCAGCAAGATCGCGGCCGTAATGCCGGCGATGACCGCGATGA







CCAGCGCGATCCAGGAGAACCGTTCCAACCAGTGCTGGGCGGCCATCCCGGCGAAGTAGACCAGTGCAGTGGTGCC






Clone Rv352




:::::::::::::Rv352SP6.seq:::::::::::::







CAATACTCAAGCTTCAAAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAANTGCGGCCCGCACCGCCGGCATCTCCCGGTCACG




(SEQ ID NO. 466)







CAGGGCCGCGGCCCGCGCCGCANCGACGGNGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGTTCTCGGCGTCGTCNCGTTCACTA







ATCGCGGTGCTC







:::::::::::::Rv352T7.seq:::::::::::::







TACGCTGGCGCTGGAGGGAGCCANNTACAACATCCACGCCAATGCTCTTGCCCCGATCGCGGCGACCAGGATGACCCAGGACATCCTGCCGCCCGAAGTACTGGAA




(SEQ ID NO. 467)







AAGCTCACACCCGAGTTCGTCGCACCGGTGGTGGCCTACCTGTGCACCGAGGAGTGTGCCGACAACGCATCGGTGTACGTCGTCGGTGGTGGCAAGGTGCAGCGAG







TTGCGCTGTTTGGCAACGACGGCGCCAACTTCGACAAACCGCCGTCGGTACAAGATGTTGCGGCGCGGTGGGCCGAGATCACCGATCTGTCCGGTGCGAAAATTGC







TG






Clone Rv353




:::::::::::::Rv353SP6.seq:::::::::::::







GCTTTTCCCGTCCGTCNNCGCTCAACCGCGTGAGGCCGAAGCGGNTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACNCCC




(SEQ ID NO. 468)







GACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGCTGGCCACGGCGACCGANCGGCTGCNNNTGGGCGCGTTGGTGACCGGCAATACCTACCGCAGCCCGA







CCCTGCTGGCAAANATCATCACCACGCTCGACGTGGTTAGCGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGANCTGGAAC







:::::::::::::Rv353T7.seq:::::::::::::







CNGCTTTTTAATGGCCTTGACNTGGGCGNGCCGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACT




(SEQ ID NO. 469)







TTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCATTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGC







GGTTCCGCTGACCAATACGGTCGGTCCCAAGATGACCCAGTACTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGG







AACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATTGTTAACCTGGGCTACGGCGACCCGGCCTATG






Clone Rv354




:::::::::::::Rv354SP6.seq:::::::::::::







CTCAAGCTTGCCGGGAGGGTGCATGGCCGACTCGGATTTACCCACCANGGGGCGCCAACGCGGTGTCCGCGCCGTCNAGCTGAACGTTGCTGCCCGCCTGGAGAAC




(SEQ ID NO. 470)







CTGGCGCTGCTGCGCACCCTGGTCGGCGCCATCGGCACCTTCGAGGACCTGGATTTCGACGCCGTGGCCGACCTGAGGTTGGCGGTGGACGAGGTGTGCACCCGGT







TGATTCGCTCGGCCTTGCCGGATGCCACCCTGCGCCTGGTGGTCGATCCGCGAAAANACGAANTTGTGGTGGAGGCTTCTGCTGCCTGCGACACCCACNACGTGGT







GGCACCGGGCAGCTTTAGCTGGCAT







:::::::::::::Rv354T7.seq:::::::::::::







CCGACGCCGTCGTGGCCACCAACACCGCGACCAGCACCGTGACCCGGACCGGGGTGCCGCGCGAACCGGTCTTGGCCAATTGCCGCGGCACCAAGCCGTCGCGCGC




(SEQ ID NO. 471)







CATGGCGAACAGCACGCGGCATTGCCCGAGCATCAACACCATCACCACCGTGGTAAGCCCGGCCAGCGCGCCGACGGAGATGATGCCGCTGGCCCAGTACACCCCG







TTGGCCTGGAACGCGGTGGCCAGATTTGCCGGCCCGCGGCCCGGTACGGTCCGCAGTTGGGTGTATGGAACCATGCCCGACAGCACCACCG






Clone Rv355




:::::::::::::Rv355SP6.seq:::::::::::::







TTNACTGGCCTTTGGTCCACACTAGACAATACTCAAGCTTCCAGGACATCGTCATCGCGACCAAAACCGCGAGCTAGGTCGGCATCCGGGAAGCATCGCGACACCG




(SEQ ID NO. 472)







TGGCGCCGAGCGCCGCTGCCGGCAGGCCGATTAGGCGGGCAAATTAGCCCGCCGCGGCTCCCGGCTCCGANTACGGCGCCCCGAATGGCGTCACCGGCTGGTAACC







ACGCTTGCGCGCCTGGGCGGCGGCCTGCCGGATCAGGTGGTAAATGCCGACA







:::::::::::::Rv355T7.seq:::::::::::::







NGACGTCTTCCATCCGCGCGTCGTTTTGGCGGGTTGGCCACAGCAGCCCGCCGGTGACGGCGACGATGCTGGGCTGGTTGCGGCCCTGCGCCACCGCGGCTTGCAT




(SEQ ID NO. 473)







GCTGGTTGGCTGTCTTGGGACGATCCCGAAATAGTCCACGCGGATCTGGTGATTTTGCGGGCTACCCGCGATTACCCCGCGCGGCTCGACGAGTTTTTGGCCTGGA







CTACCCGCGTGGCCAATCTGCTGAACTCGCGGCCGGTGGTGGCCTGGAATGTCGAGCGCCGTTACCTA






Clone Rv356




:::::::::::::Rv356SP6.seq:::::::::::::







CTTCCTCCTGAGTACCNCCCGTNTACTTTGGGATGGGTAAAAAGGCGAATCNCCGTTTGGTCACGAACGCCGGGAGGGACAATCTCGGGCGGCTGGGGCCTCTCGC




(SEQ ID NO. 474)







GGGAANGCCCGAATGTACGGTGTCTCGACACTTCCCNTCCCCCTCCG







:::::::::::::Rv356T7.seq:::::::::::::







GAGCATCGGGACNTACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCNGCGACCACATTCAGCAGATGGCCAGCGCG




(SEQ ID NO. 475)







TGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCNTGATCNACATCGTCACCGCCGCACCACTGCCCGGCCTCGGGTTCACGCAGCCGTTGC







CGCCCNCAGCGGACGATCACNTCGCCGCGATCGCC






Clone Rv357




:::::::::::::Rv357SP6.seq:::::::::::::







TACTCATGANCATCCTTTAATCANNGCTTTGCGTTTTTTTATTAAATCTTGCAATTTACTGCAAAGCAACAACAAAATCGCAAAGTCATCAAAAAACCGCAAAGTT




(SEQ ID NO. 476)







GTTTAAAATAAGAGCANCACTACAAAAGGAGATAAGAAGAGCACATACCTCAGTCACTTATTATCACTAGCGCTCGCCGCAGCCGTGTAACCGAGCATAGCGAGCG







AACTGGCGAGGAAGCAAAGAAGAACTGTTCTGTCAGATAGCTCTTACGCNCA






Clone Rv358




:::::::::::::Rv358SP6.seq:::::::::::::







CTCAAGCTTCAGGTCAATGTGCNCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGANACNCTGCCAAGGCCACCGAATACAACAACGCCGCCGAGGCGT




(SEQ ID NO. 477)







TCGCANCCCAGCTGGTGACCGCCGAGCANANCGTCAAAAACCTCAAGACGCTGCATGACCAGGCGCTTANCNCCGCANCTCAGGCCAAGAAGGCCGTCNAACGAAA







TGCGATGGTGCTGCACCANAAGATCGCCGAGCGAACCAAGCTGCTCAGCCNG







:::::::::::::Rv358T7.seq:::::::::::::







CATGGTGGCACTGTAGCGACGTGCTGCAATCAAGGTCATGCCCGACTCTGGTCAGCTCGGANCCGCTGACACCCCGCTAAGGCTGCTCAGCTCGGTGCATTACCTC




(SEQ ID NO. 478)







ACCGACGGCGAACTCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCGGGCGAACTTCATCATCAGCTTGGACGGCGGCGCTACCGTCGATGGCACCA







GCGGGGCGATGGCCGGGCCCGGCGACCGATTCGTCTTCAACCTGTTGCGTGAACTTGCCGACGTCATCGTGGTCGGCGTGGGCACCGTGCGCATTGAGGGCTACTC







CGGCGTCCGGATGGGTGTCGTCCAGCGCCAGCAC






Clone Rv359




:::::::::::::Rv359SP6.seq:::::::::::::







TACTCAAGCTTGCGGGTGATCGCCTTGGTCAACGGCACCGTGATCGGATCGGGGTCNACCGCACAAATGGACTGGAGCTTCGGCGAANTCATCGCCTATGCCTCGC




(SEQ ID NO. 479)







GGGGGGTGACGCTGACCCCGGGTGACNTGTTCGGCTCGGGCACGGTGCCCACCTGCACGCTCGTCTATCACCTCNGGCCACCGGAATCATTCCCGGGCTGG







:::::::::::::Rv359T7.seq:::::::::::::







GTTGGNGCCTCGTCGGCGAACAGTTCTCGCACGATTTCCGGATTAGCGGGACTGGTCACCAGTTGGGTATGCGGGAAGGCGCTGACGTTCGCCGCGATTAGCTGTT




(SEQ ID NO. 480)







TGATGGACGCGGTGGTGATGTTCTGATCACGGAACTGGCTGTAATAGCCCAGGGTCGCCACGCTTTCATCCGGGCCCGGACCCGGCGCACCGAGCGTGTCGCGCAG







GTATGCGACGTGATTTTCGCTGAAGTCCCCGTACCCGGAGAACT






Clone Rv35




:::::::::::::Rv35SP6.seq:::::::::::::







TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGANCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT




(SEQ ID NO. 481)







ACTCAAGCTCCAGGTCAATGTGCGCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGAGACGCTGCCTTTGTCACCGAATACAACAACGCCGCCGAGGCG







TTCGCAGCCCAGCTGGTGACCGCCGAGCAGAGCGTCGAAGACCTCAAGACGCTGCATGACCAGGCGCTTAGCGCCGCAGCTCAGGCCAAGAATGCCGTCGAACGAA







ATGCGATGGTGCTGCGGCATAAGATCGCCGAGCGAACCAAGCTGCTCAGCCAGCTCGAGCAGGCGAAGATGCACGAGCA







:::::::::::::Rv35T7.seq:::::::::::::







CAGGCATGCAAGCTTCGGAGGCAGACCCGTGCATGGTGGCACTGTAGCGACGTGCTGCAATCAAGGTCATGCCCGACTCTGGTCAGCTCGGAGCCGCTGACACCCC




(SEQ ID NO. 482)







GCTAAGGCTGCTCAGCTCGGTGCATTACCTCACCGACGGCGAACTCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCGGGCGAACTTCATCAGCAGC







TTGGACGGCGGCGCTACCGTCGATGGCACCAGCGGGGCGATGGCCGGGCCCGGCGACCGATTCGTCTTCAACCTGTTGCGTGAACTTGCCGACGTCATCGTGGTCG







GCGTGGGCACCGTGCGCATTGAAGGCTACTCCGGCGTCCGGATGGGTGTCGTCCATCGCCA






Clone Rv360




:::::::::::::Rv360SP6.seq:::::::::::::







TACTCAAGCTTGGGGTGGCGCTGTCGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGTC




(SEQ ID NO. 483)







CAAAATCACCCTCGCCCANACCTGCTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGGGTGTCCACACCGGAGGACCCGGCGTCGGCGCGGTTC







GGCNAAACGTTGTGGGANTTCCTGCCCCGCANTGTTATCGGCGGCTTGCGCT







:::::::::::::Rv360T7.seq:::::::::::::







GGCCATCGCCACCGCNCCGCGGCGAACGCTCAAAGGCACCTACTGGCACCAAGGCCCCACACGTCACCCTGTGACCTCCTGCGCCGACCCCGCCCGAGGTCCTGGC




(SEQ ID NO. 484)







CGTTACCACCGAACGGGCGAGCCGGGAGTCTGGTACGCATCGAACAAAGAGCAAGGTGCATGGGCGGAGTTGTTCCGCCACTTCGTCGATGACGGGGTCGATCCAT







TCGAGGTCCGTCGCCGCGTCGGTCGAGTGGCGGTCACACTCCANGTACTCGACCTCACAGACGAGAGGACTCGATCCCATCTAGGTGTGGACGAAACAGATCTTCT







GTCCGACGACTACACCACCACCCAGGCCATCGC






Clone Rv361




:::::::::::::Rv361SP6.seq:::::::::::::







GCTTGCGGGTGATCGCCTTGGTCAACGGCACCGTGATCGGATCGGGGTCNACCGCNCAGATGGACTGGANCTTCGGCGAANTCNTCGCCTATGCCTCGCGGGGGGT




(SEQ ID NO. 485)







GACCCTGACCCCGGGTGACNTGTTCGGCTCGGGCACGGTGCCCACCTGCACGCTCGTCAAGCACCTCNGGCCACCGGAATCATTCCCGGGCTGGCTGCACNACGGC







GACNTGGTCNCCCTCCAGGTCGAAGGGCTGGGCNAAACAANGCAGACCGTCCGGACAANCGGCACTCCTTTTCCGTTGGCTCTTCGGCCGAATCCGGACGCCNAAC







CCGACCGGCG







:::::::::::::Rv361T7.seq:::::::::::::







GTTCTCGCACGATTTCCGGATTAGCGGGACTGGTCACCAGTTGGGTATGCGGGAAGGCGCTGACGTTCGCCGCGATTAGCTGTTTGATGGACGCGGTGGTGATGTN




(SEQ ID NO. 486)







CTGATCACGGAACTGGCTGTAATANCCCAGGGTCGCCNCGCTTTCATCCGGGCCCGGACCCGGCGCACCGAGCGTGTCGCGCAGGTATGCGACGTGATTTTCGCTG







AAGTCCCCGTACCCGGAGAACTCGAACACGCTGAGGCGCTCGTCACCGTCGTNNCGGCGACCAAGCGCGGCGAGCAACTGCGCAAAATCGTTAAGANAGGTCGAAT







CGTTGAAATTCGGCACCACCTGCACC






Clone Rv363




:::::::::::::Rv363SP6.seq:::::::::::::







CACAAGACAATACTCAAGCTTCAGGTCAATGTGCNCCAAGCCCTGACGCTGGCCGACCAGGCCACCGCCGCCGGANACGCTGCCAAGGCCACCGAATACAACAACG




(SEQ ID NO. 487)







CCGCCGAGGCGTTCGCAGCCCAGCTGGTGACCGCCGAGCANANCGTCNAAAACCTCAAGACGCTGCATGACCAGGCGCTTANCGCCNCAGCTCAGGCCAAGAAGGC







CGTCGAACGAAATGCGATGGTGCTGCAGCANAANATCGCCGANCGAACCAAGCTGCTCAGCCAGCTCGAGCAG







:::::::::::::Rv363T7.seq:::::::::::::







CCACCCGTGCATGGTGGCACTGTAGCGACGTGCTGCAATCAAGGTCATGCCCGACTCTGGTCAGCTCGGAGCCGCTGACACCCCGCTAAGGCTGCTCAGCTCGGTG




(SEQ ID NO. 488)







CATTACCTCACCGACGGCGAACTCCCCCAGCTTTACGACTATCCGGATGACGGCACCTGGTTGCGGGCGAACTTCATCAGCAGCTTGGACGGCGGCGCTACCGTCG







ATGGCACCAGCGGGGCGATGGCCGGGCCCGGCGACCGATTCGTCTTCAACCTGTTGCGTGAACTTGCC






Clone Rv364




:::::::::::::Rv364SP6.seq:::::::::::::







GCTTTCCGCCGATACCCNCCATGTCCCGCACATCCAGGACTTCTGGGGGGATCCGCTGACAGCGGCGGGATCCCAAAGTGCGGATGATCGGGCCGCCTACGTCGTG




(SEQ ID NO. 489)







GTGTACCTCGNCGGTAACAACGAAACCGAANCGTATGACTCNGTCCACGCGGTG







:::::::::::::Rv364T7.seq:::::::::::::







CAACCCGANTTGGCTTTCGGCGCCNTCGGTGAGGACGGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCGGTCG




(SEQ ID NO. 490)







AACGCAAGCAGCTGATCGATCTACNACGCCGNGNGGAACGCTTCNGCCGCGGGCGTGACCGCNTCCCGTT






Clone Rv365




:::::::::::::Rv365SP6.seq:::::::::::::







GGGATGGGCAAAAAGGCGAAGCACCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGTACGGCGTTTCAAC




(SEQ ID NO. 491)







ACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCCAGCGTCCCCGCGGGTAGTCGCCGCCCGG







GCGG







:::::::::::::Rv365T7.seq:::::::::::::







CAGCAGACCAACAAGAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCACATTCAGC




(SEQ ID NO. 492)







AGATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCACGGTT






Clone Rv366




:::::::::::::Rv366SP6.seq:::::::::::::







CTCAAGCTTGACTGGCCACCCACCGGCATGACCACCGACAGGCCCGACTGGTCGTACCACTCGAACGCCGGGGTGTTTGA




(SEQ ID NO. 493)







:::::::::::::Rv366T7.seq:::::::::::::







TTGGTGCCCGGAATGGCGAGTCCCATTTANTCGCTGATTTGTTTGAACAGCGACGAAACCGGTGTTGAAAATGTCGCCTGGGTCGGGGATTCCCTCTCCAAGCAAG




(SEQ ID NO. 494)







AGTAACTGGCCCCAAATAAAGTTACTCGTCGTCTTGCAAAGACCGCTACCCGATGCCATTTATGTGTTTCCTTACGCTCNNNNTTCCGGTGCGCCATCATTATCTG







CACCTTTGCACTGCACATTGAGCTTAGCAGCGCTCG






Clone Rv367




:::::::::::::Rv367T7.seq:::::::::::::







GAATTNGCTTTCGGCGCCATCGGCCCAGGACCGCGTGCGGGTGCTCAACGACGACGTCGTCCGCGGGACACACCTCGATGCTGCCGCCATGGACGCGGTCGAACGC




(SEQ ID NO. 495)







AAGCAGCTGATCGAGCTACAACGCCGCGCGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCNGTGATCGTCGATGACGGCATCGCCA







CCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCGGTCCCGATCGGCCCAGACGACATCGTGGCGAGATTCGC







CGGGTACGCCGATGAAGTGGTGT






Clone Rv368




:::::::::::::Rv368SP6.seq:::::::::::::







TAAAGCTTTCGTCAGTTCATNGNGCCCCCGGACCAACAAAAGCATCGGGACATACGGAGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCN




(SEQ ID NO. 496)







AACGACGCCAGCGACCACATTCAGCAGATGGCCAGCGCGTGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATCNACATCGTCACCG







CCGCACCACTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGACGATCACNTCGCCGCGATCGCCCTGTTCGGGAATCCCTCGGGCCGCGCTGGCGG







GCTGATGAGCGCCCTGACCCCTCAATTCGGGTCCAANACCATCNACCTCTGCAACAACGGCGACCCGATTTGTTCGGACGGCAACCGGTGGCGANCGCACCT







:::::::::::::Rv368T7.seq:::::::::::::







CCGGGAGGGACCATCNCGGGCGGCTNCGGCTTCTCTCCGGAAGGTTCTANNGTNNNGCGTTTCNACNCTTCCCGTCGCCCTGCGACCGCCGAACATTCGGGGTATG




(SEQ ID NO. 497)







GNNGCANCCTGTNAGCATCCNGGCCGGGC






Clone Rv369




:::::::::::::Rv369SP6.seq:::::::::::::







CTCAAGCTTCCGCATCAGATCGCTATAGAACCGGTGCGCGTCCCCACCGAGTGGCTGGTCGCCTTCCAGCACGATCGTTACCGCGTTATCGGAATCAAACTCNCCG




(SEQ ID NO. 498)







AACACCTGACCAACGCGCTTGATCGCCTGAATCGATGCGGCGTCGCTGGGGCTCATCGATACCGAGTGTGCTTTTCCGACCACTTCCAGTTGCGGTACGGCGAGAT







TGACAAAGGCGGTGAAGCCCAGCCAGAGCAGGACGATCACCNCCGCAAACCGGCGGATTTGCCCG







:::::::::::::Rv369T7.seq:::::::::::::







GCTTGGCAGCCTGCGGCTGGGCGCCCTNGAGCTCTTCGATCTGGATCTCCGGACTCGAGATGCTCACTTGCCCGGCCGTGGACGTACCCATTGCGGCCGGGACCCC




(SEQ ID NO. 499)







AGCGCCCCAGGTGACCAGCGAGTTGGGCTGCACGCTGACCGGCCCGTCGGGGTCGACGCCGGTAACGGTCAGCAGCTCCGANGTCCNNCTGATCCCGACCGCAGCT







GCCAATGCGCGGCTGGCAGCCGACGTGGATGTGCCGGGGCCTAGATCGCGGGGCAGCAGCGAGACCGCGTCACCGACGGTCATCACCTTGCCGAGTTTNGGCCTGC







CGCAN






Clone Rv36




:::::::::::::Rv36SP6.seq:::::::::::::







GCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTNCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATCTAGGTGACACTATAGAATA




(SEQ ID NO. 500)







CTCAAGCTTGAGCCATCGGGCTATCAGCTGGTTGATGTCCCG







:::::::::::::Rv36T7.seq:::::::::::::







CAGGCATGCAAGCTTGTCGTCTATCACATCCGACCACCAACCGCCCGACGGCTCGGCAGAACGCCTCCGCATATGGGTCGACGACCAGCGGGTCGGACTTCTGGGC




(SEQ ID NO. 501)







TGCCAGCGCTCGCGCCGTCGCGACAAACAGCGCGGTCGAACCGACACTCCTTGTGATGTCCCACCTATCACCTTCGGTACGCACCCAATCGACCCTACGCGGCTAG







CTCAGCCCCGATCTTCCAGAGCTCCGCCCG






Clone Rv370




:::::::::::::Rv370SP6.seq:::::::::::::







GCTTTTTGAGCGTCGCGCGGGGCGGCTTCCCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGCCCACCCTCATT




(SEQ ID NO. 502)







GGCGATGGCGCCGACNATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAATTCCGGTCTACGCTTGGGCCTTTGCGGACGGTCC







CGACGCTGGTCGCGGTTG







:::::::::::::Rv370T7.seq:::::::::::::







CGANCCTGTTCGACGGCTACCTGAATCACCCCGATNCCACCGCCGCGGCGTTCGACGCCGACAGCTGGTACCGCACCGGCGACGTCGCGGTGGTCGACGGCAGTGG




(SEQ ID NO. 503)







GATGCACCGCATCGTGGGACGCGAGTCGGTCGACTTGATCAAGTCGGGTGGATACCGGGTCGGCGCCGGTGAAATTGAAACGGTGCTGCTCGGGCATCCGGACGTG







GCGGAGGCGGCAGTCGTCGGGGT






Clone Rv371




:::::::::::::Rv371SP6.seq:::::::::::::







NAAGCTTTGTCACACCAAGTGTTTCNACCAGNCGCTCCATCCGGCGAAGTGGATACTCCCAGCAGGTAGCAGGTCGCCACCACGCTGGTCAGTGCGCGTTCAGCTC




(SEQ ID NO. 504)







GCTTGCGGCGCTGCAGCAGCCAGTCCGGGAAATAGCTGCCCTGGCG







:::::::::::::Rv371T7.seq:::::::::::::







CGCTGGNCGCCGGCGCTGGGCTGCGGTAACCAATTACCACAACACTTTTCGGTAGCCGAACAGCGGCGCGTACCAGCGAAATGGCACAGCCACCGCAGTCGCCGAC




(SEQ ID NO. 505)







ATCCCGCGAAGATGTGGCAGATTTTCGTGCGGTCGAGCCGGCGAAGGCCTAGCGTCATTGTTGCCTGGCAAGGTTGCTGGGCCCGG






Clone Rv373




:::::::::::::Rv373SP6.seq:::::::::::::







CTCAAGCTTCTTCTGCCCCTTGCCGTTNCGGATNACATCCCGCAGCGACTCGGCTTCGGCGTCGATGTCGAAGTTCTCGATCAGCTTCTGGATCGACTCCGCGCCC




(SEQ ID NO. 506)







ATGGCACCGGTGAAGTACTCGCCGTAGCGGTCGACNAGTTCGCGGTAGAGGTTTTCGTCNACNATCAGCTGCTTGGGCGCCANCTTGGTGAAAGTGCTCCAAATGT







CCTCCAACCGGTCCAGCTCACGCTGCGCGCGGTCACGGATCTGGCGCATCTCGCGCTCGCCGCCGTCGCGAACTTGCGCCGCGCATCGGCCTTGGGGCCC







:::::::::::::Rv373T7.seq:::::::::::::







GTTCACACCTACCTACTATGCCNCAATTCNCCGACACGGGTGGCATCAACACGGGCGATAAGGTGGAAATCGCTGGGGTGAACGTCGGGCTGGTGCGCTCGCTGGC




(SEQ ID NO. 507)







AATCCGCGGCAACCGCGTGTTGATCGGATTCTCGTTGCCCGGCAAGACAATCGGGATGCAAAGCCGGGCAGCAATTCNCNCCNACACCATTCTTGGCCGTAAGAAC







CTGGAGATCGAACCCCGCGGTTCGGAGCCGTTGAAACCCAACGGTTTCCTGCCGTTGGCGCANACCACTACGCCATACCAAATC






Clone Rv374




:::::::::::::Rv374SP6.seq:::::::::::::







CTCAAGCTTTACGCCGACGCCGGCCTACACAACACCAAGGAAACGATTGCCTACTGCCGAATCGGGGAACGGTCCTCGCACACCTGGTTCGTGTTGCGGGAATTAC




(SEQ ID NO. 508)







TCGGACACCAAAACGTCAAGAACTACGACGGCAGTTGGACAGAATACGGCTCCCTGGTGGGCGCCCCGATCGAGTTGGGAAGCTGATATGTGCTCTGGACCC







:::::::::::::Rv374T7.seq:::::::::::::







TCCCNCATGGGATAACGGGTTTAGATTTCNACAACGGCACCGTGTTTCTCAACAAGCCGGTCATCAGCTGGGCCGGCGACAACGGTATCTACTTCACCCGCTTTCG




(SEQ ID NO. 509)







CCCGTACAAGAAAAACCACTAGGCCACCATCGAGTCCAAGAACAACCACCTGGTCCGCAAGTACGCGTTCTACTACCGCTATGACACCGCCGAGGAACGCGCCGTG







CTCAACCGGATGTGGAAGCTGGTCAACGACCGCCTCAACTACCTCACCCCGACCATCAAACCGATC






Clone Rv375




:::::::::::::Rv375SP6.seq:::::::::::::







CTCAAGCTTGGGTGTTGCCGATCACCGGAAGCCNCATGATCAGCCACGTTTCGCGCCGCCCGGCATACGGCGGCGTACCGATCTCCGCGTCATACACCCGCGGGTA




(SEQ ID NO. 510)







ATCGCCGACGGTGCCGGTTCGCGAGCCGAAGGTGACAACGCTGATTGAATCNAGTTCCANGTCCAGCGGGT







:::::::::::::Rv375T7.seq:::::::::::::







TNAACAGCTCGCGGCAGCCCACGACCTGCTGCGTCGGATTGCCGGCGGCGAGATCAATTCCAGGCAGCTCCCGGACAATGCGGCTCTGCTGGCCCGCAACGAANGA




(SEQ ID NO. 511)







CTCGAGGTCACCCCGGTGCCCGGGGTCGTGGTGCACCTGCCGATCGCACAGGTTGGCCCACAACCGGCCGCTTGATGNNNNGTCGGCAAGCCCGGCAGTNGCCAAA







CCCAGCGTGATCANGCTCGGCTCGCGAGTTCGGCGAANAAGTGGCTCGCCTGATCACCTACCATCGGCCANGATCTGCGTGTCA






Clone Rv376




:::::::::::::Rv376SP6.seq:::::::::::::







GCCANCCGGCTTGGCGTCGACTCCCGTTCNGCACATCATACGGTCCCCGGTACTGTCCAACTGCGCCGGTGCGCTAGCCAAACGTCACGACTCTCAGTGATCCCAG




(SEQ ID NO. 512)







TTCGTGATCCGGCCGGTGGCGCCGCTGCGGCGGGGGCTNATNTACTTCGGACTNATTATCTCATCCAAAGGACACCGGGCCGGTGGCTGGAATCCCATGGTGCGAT







CGGCCACACAN







:::::::::::::Rv376T7.seq:::::::::::::







CCGACCTGGTATCTTCCGATAGCGCGCGTTGATATCCGGTCTGATCTCCTGCCCTTAACGCCGGATCTCAGCAGGTCCCCATGCAAAGATCCGAGGTGTCCCNGAT




(SEQ ID NO. 513)







CTAGGGGTCCTCGTCCTCCAGATGATGGAGCAAGTCGGCCC






Clone Rv377




:::::::::::::Rv377SP6.seq:::::::::::::







CTCAAGCTTCGGCTCAGGCGGCGCTGCCGGTAACGTCGCTGACCGGTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCAAGACACTGGCGCA




(SEQ ID NO. 514)







GGCTATCGCACCCGTTATCGGCTACAAACAAATCGCGGTATGC







:::::::::::::Rv377T7.seq:::::::::::::







CATCACCTGNTTCATGAACTGGAAGCACCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGCC




(SEQ ID NO. 515)







GCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACGAACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCC







ACCGACCGGGCCCGGGTGTGGGGTGT






Clone Rv378




:::::::::::::Rv378SP6.seq:::::::::::::







AGCTTAGCTTCCCGCCCCGGCAATAGGGCTCCAGCTCATCCGGTGTGACCAGATAGGGGCCCAGGGTGATACCGCTGTCTTTGCCCTTGGCCTGTCCGATGCGCAG




(SEQ ID NO. 516)







CTGGCCCTCCAGCATCTGCAGGTCCCGTGCGGACCAGTCGTTGAAAATGGTATAGCCGATGATCGACCG







:::::::::::::Rv378T7.seq:::::::::::::







CCNGAACAGAAGCGGNGGTTCCTACCGCGGTGTGCGGCCGGCGCGATATCGGCCTTTTTACTAACCGAACCCGATGTGGGCTCCGATCCGGCGCGCATGGCATCGA




(SEQ ID NO. 517)







CGGCGACGCCGATCGATGACCGCCAGGCTTACCACCTT






Clone Rv379




:::::::::::::Rv379SP6.seq:::::::::::::







CTCAAGCTTGCGCGACTCGACAAGCATTCTTGACAGTTGTTTTGGCTCGGCATGGTTAGCCAAGGTTCTGCGGTCCCACCAGATCATCTTGGTCCGGTAGCGCTCG




(SEQ ID NO. 518)







TCCGGGTATGCTGCCGCCGGGATTCTCGCTGCTATTACTCCCCCCGAAGAACGCCACCGGTCCAGCGC







:::::::::::::Rv379T7.seq:::::::::::::







GCNAGGCGGTATAGCTTCCCGTCGTACCGGCGACCGCCAGCCGAGAAGCTCGTTTTCCCAGTGTTGCTGGGGATTCTCACGCTGCTGCTGAGTGCGTGCCAGACCG




(SEQ ID NO. 519)







CTTCCGCTTCGGGTTACAACGAGCCGCGGGGCTACGATCGTGCGACGCTGAAGTTGGTGTTCTCCATGGACTTGGGGATGT






Clone Rv37




:::::::::::::Rv37SP6.seq:::::::::::::







GTGTGGAACCGTGAGCGGATAACAATTTCACACAGGAAACAGCTNTGACCTTGATTACGCCAAGCTATTTAGGTGAGGCTATATTAATACTCAAGATTGCGGTCGA




(SEQ ID NO. 520)







GCACATCGGCCCAAGAACCGCCGAAGGCACGGCGGAACGCCTGCGGCACATGGGGCGACGACCAGCGGGTCGGACTTCTGGGCTGTCCAGCCGGATCGCGCCGTCG







CGA







:::::::::::::Rv37T7.seq:::::::::::::







CACTGTCAGTACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAAGCCGAACGCGAAACGAGAACGTGTT




(SEQ ID NO. 521)







CCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCACGCAGCACCGGGACGGATGTCAGCCACCACGCCCATCTGGGGTGGTAGCGGGGAAAT







ACGGCTAACGCGGCTCCGGTGCCGGCAGCCCAGCGCAGACCCTCGGCGGCGGACACGGCAAACAACGACGACCCATAGTTGTTCTTTGCCGGATGGCCGTGTTTGC







GGACATATCGGGCGGCGGCGCGGGCGCCGCCGAGGTAGTGGCTGAGGCCCATCTCGTGCCCGCCGAATGGCCCCAGCCAAACCGTGTA






Clone Rv381




:::::::::::::Rv381SP6.seq:::::::::::::







CTCAAGCTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCGCAACATGAGCCANCCTCTCGTCGGCGGTCGGGT




(SEQ ID NO. 522)







GCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACCCTGAAACCAGCTTCCATATCCCGCGACNAACGAC







:::::::::::::Rv381T7.seq:::::::::::::







CTCAGAAGCCGCTAGCTGGTAGAGTCGCTGACCGGTGCACGTGGCGNCAATGTGCGCTGCCGGTTCGCG




(SEQ ID NO. 523)






Clone Rv382




:::::::::::::Rv382SP6.seq:::::::::::::







CTCAAGCTTGCGCTCATCAAGCGCGAACAGCAGGGCGGTCGGCTGGTCGCCATGACGGGTGACGGGACCAATGACGCACCCGCGCTCGCGCAAGCCGATGTCGGGG




(SEQ ID NO. 524)







TGGCNATNAATACCGGCACCCAGGCGGCCCGGGAAGCCGGCAACATGGTCNATCTCCACTCC







:::::::::::::Rv382T7.seq:::::::::::::







ACTTCTATTTCGACTGGTGTGCTGTGGCGCGATCCGACTGCCGGCGTGGTCAAGGCCGGCCAGTTGTGGGATNCCACAGGCAC




(SEQ ID NO. 525)






Clone Rv383




:::::::::::::Rv383SP6.seq:::::::::::::







GCTTGTCGTATTCCGTGGCACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAAGCCGAACG




(SEQ ID NO. 526)







CGAAACGAGAACGTGTTCCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCAC







:::::::::::::Rv383T7.seq:::::::::::::







CGATATTCGTCGGCCGCGTTGTCTCGACTGGGTCGCGT




(SEQ ID NO. 527)






Clone Rv384




:::::::::::::Rv384SP6.seq:::::::::::::







GACCTCGGCCACCAAGCCGGACGCGACCGTCGAGGTGGCGATCCGGCTTGGCGTCGACCCGCGTAAGGCAGACCAGATGGTCCGCGGCACGGCCANCCTGCCACAC




(SEQ ID NO. 528)







GGCACTGGTAAGACTGCCCGCGTCGCGGCN







:::::::::::::Rv384T7.seq:::::::::::::







CCGGAAGTCTAGGGGACGACCTACTCAGCGCAAAATGTCGCTAATGTGAGTCCGCCCCACCAGGGCAGATCAACCCATGTCGATGATGACCTACCCGGATACCGGA




(SEQ ID NO. 529)







TTGGCGGT






Clone Rv385




:::::::::::::Rv385SP6.seq:::::::::::::







AGCTTCAGTTCCTCCACGACGCGTTCCCAAATGAATTTCCCGATCCCACAATCTCGGTTCAGATACAGGTCGCCATACCCCTTACTTCGGNAACGCTGGGCGGATT




(SEQ ID NO. 530)







GGCCCTGCCGCTG







:::::::::::::Rv385T7.seq:::::::::::::







CCGCCTACGGGTCGAACATGCATCCCGAGACCGATGCTCGAGCGCGCACCCCACTCGCCGATGGCCGGAACCGGCTGGTTACCCGGGTGGCGGCTGACC




(SEQ ID NO. 531)






Clone Rv386




:::::::::::::Rv386SP6.seq:::::::::::::







GCGGCTGGTTACGACTCCCTGTTTGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCGACCAGCCGATGCTGGAGGCCTACACGGCCCTTGGTGCGC




(SEQ ID NO. 532)







TGGCCACGGCGACCGAGCGGCTGCAACTGGGCGCNTTGGTNACCGGCAATACCTACCGCAGCCCGACCCTGCTGGCAAAGATCATCACCACGCTCGACGTGGTTAG







CGCCGGTCGAGCGATCCTCGGCATTGGAGCCGGTTGGTTTGAGCTGGAACACCGCCAGCTCGGCTTCGAGTTCGGCACTTTCAGTGACCGGTTCAN







:::::::::::::Rv386T7.seq:::::::::::::







GCCTTTCCGCACAATCTGTACCCCAGGACCNTCTAAAAAATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACTTTGTGTCGACCCTCAACGCCA




(SEQ ID NO. 533)







TTGCCGGCACCTACTACGTGCACTCCAACTACTTCATCCTGACGCCGGAACAAATTGACGCAGCGGTTCCGCTGACCANTNNTGTCGGTCCCACGATGACCCAGTA







CTACATCATTCGCACGGAGAACCTGCCGCTGCTAGAGCCACTGCGATCGGTGCCGATCGTGGGGAACCCACTGGCGAACCTGGTTCAACCAAACTTGAAGGTGATT







GTTAACCTGG






Clone Rv387




:::::::::::::Rv387T7.seq:::::::::::::







GCAGACCAACAAGATGCATCGGGATCATACGCCGTCAACTACCCGGCCAACGGTGATTTCTTGGCCGCCGCCCAC




(SEQ ID NO. 534)






Clone Rv388




:::::::::::::Rv388SP6.seq:::::::::::::







CTCAAGCTTGCCAAAGAGACCTCGTCCACCAAGCNGGACGCGACCGTCNAGGTGGCGATCCGGCTTGGCGTCCACCCGCGTAAGGCANACCANATGGTTCGCGGCA




(SEQ ID NO. 535)







CGGTCAACCTGCCACACGGCACTGGTAANACTGCCCGCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGCGGATGTTGTCGGGAG







TGACAATCTGATCGANAGGATTCAGGGCGGCTGGCTGGAATTCGATGCCGCGATCGCGACACCGGATCAGATGGCCAAAGTCGGTCNCATCGCTCGGGTGCTGGGT







C







:::::::::::::Rv388T7.seq:::::::::::::







CCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGAAAG




(SEQ ID NO. 536)







TCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCNTACTCGATGTGCGCGACCTTGGCGTTG







ACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCGTC






Clone Rv389




:::::::::::::Rv389SP6.seq:::::::::::::







GGCGGCTGCGTCGGCGAGATGATCGCCCGGTGCCACCCCGATCCGTGCCTCGGTCAGCGCCAACGTGCTTTCCGGTCCGGCGACCACCATGTCGCATGCGCCGAC




(SEQ ID NO. 537)







:::::::::::::Rv389T7.seq:::::::::::::







GCAATCGCCTTGGCGGTCGCCGGGTTGTCACCGGTGATCATCNCGGNGCGGATGCTCATNCGGCGCATTTCGTCNAATCGTTCCCGTATGCCCACCTTGACGATGT




(SEQ ID NO. 538)







CCTTCATATGGACCACGCCGATGGCCCNCGCGCTNCTG






Clone Rv38




:::::::::::::Rv38SP6.seq:::::::::::::







CCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCA




(SEQ ID NO. 539)







AGCTTCCACATCGGTATGCCAAAGCATTGCGCCGCTATCGATTTCGCGCTGGCATCGCCAAGGTGGACTTCTTGCTCAGCGACGAGATCCCGTGGTCGGATCCGCG







GCTGCGGCGGGCTGCGACCCTGCATCTCGGCGGCACCCGTGACCAGATGGCGCGCGCCGAGGCAGACGTCGCGGCGGGACGCCACGCCGACTGGCCGATGGTGCTG







GCCGCGTGTCCGCACGTCGCCGACCCCGGCCGCATCGACGAAACCGGCCGCCGTCCGTTCTGGACCTATGCCCACGTGCCGTCGGGGTCCACGCTCGACGCGACCG







AGACCGT







:::::::::::::Rv38T7.seq:::::::::::::







CGCGTCCACCGCAGCGTGAGATTGGTGGCGCCATTCGTCGTGGTGTAGCTGCTGTTGGCGGCGTCGCCGTATTGTGCGGGCCAGCCTTGTGCGGGGGCCGCTTCTA




(SEQ ID NO. 540)







CCCACGAGTCGGCACTTCCGCAACCGCCCAGCTCGACCGCGATTACGGCGGCCGCAACGGCCGCCGGAAGGCGTCTCGCAAGCGCCTTATCCTTTCGCAGGTTCCC







AGATCCTTCCGCTACGTGGGTCGCTCATCGGCGGGCCCGGCCGAATGAGTACAGGTGAGGGTAACCGCTACAAATGAAGTTGGTCAGTGCTGGCCAACTGTGTAAT







GGTTGCCCGGCTCGGGTCACCACGTACATTCTGGCAAGGCGGGCGAGATTCGGTTCCTCGCGTCCTTGGCCGGTGGCGGTTCCCGGTTGTCCGTGGGCGTGTCGTG







TACGTGGTGTAAGTGTCGTGAACTCCTCAGTTTGGGCT






Clone Rv390




:::::::::::::Rv390SP6.seq::::::::::::







CTCAAGCTTGCGCTGGATCTGGCGGCTGAGCCTGTTCTTGGGCAACATGCCGAGGGATCGCCTTTTCCACCACGCGGTCGGGGTGGCGTTGCATTAGCTCACCGAT




(SEQ ID NO. 541)







GGTGCGCTTGTGCAGGCCGCCGGGATACCCCGAGTGCCGGTAAACCATCTTGTGCTGCAGTTTGTCGCCGCTGATGGCGACCTTGTCGGCGTTGATCACNATGACN







AAGTCACCGCCATCGACATTGGGGGCGAACGTCGGCTTGTGCTTGCCGCGCAGCAGGTTGGCCGCCGCGACGGCAAGGCGGCCAANCACCACGTC







:::::::::::::Rv390T7.seq:::::::::::::







TTTGGGATGGGCAAAAAGGCGAAGCNCCGCGTGGCCACGAACGCCGGGAGGGACAATCTCGGGCGGCTAGGGCTTCTCGCGGGAAGGCCCGAACGTACGGCGTTTC




(SEQ ID NO. 542)







AACACGTCGCGTCGCCCTCCGACCGCGAACATTCGGGGATGGCAGCAACCTGGTAGCACCCTGGCCGGGCGATGATCTGCAGCGTCGCCGCGGGTAGTCGCCGCCC







GGGCGGCTACAGTCTGAAACGCGATGACCATCGATGTGTGGATGCAGCATCCGACGCAACGGTTCCTACACGGCGATATGTTCGCCTCGCTGCGCCGGTGGACCGG







TGGGTCTATCCCGGA






Clone Rv391




:::::::::::::Rv391SP6.seq:::::::::::::







CTCAAGCTTCGTCATAAGACCATGGTGCGCTTTCTTTCACCCGTCCANAGTCGGGGGCATCCGCACCGGCTCGCATCGCATCATCCTCCCACGACGGGCCGCTCAT




(SEQ ID NO. 543)







CAGCTTGGGCCATTTCAATGTACTTGATACCCCGCGCTGCGGGTAGGCCACTGCNACAATTCAAACACGGTGTCACACGGTGAATANTGTCNANATGGGCTCTGAT







CAACCGTCNCAAACCCGGTTTC







:::::::::::::Rv391T7.seq:::::::::::::







GAATTCTGCGTGCACCGCTATGGGTTGCAGCAGCGGCTGGCGCCGCACACCCCACTGGCCCGGGTGTTTTCGCCCCGAACCCGGATCATGGTGAGCGAAAAGGAGA




(SEQ ID NO. 544)







TTCGCCTGTTCGATGCTGGGATTCGCCACCGCGAGGCCATCGACCGATTACTCGCCACCGGGGTGCGAGAGGTGCCGCAGTCCCGCTCCGTCGACGTCTCCGACGA







TCCATCCGGCTTCCGCCGTCGGGTGGCGGTAGCCGTCGATGAAATCGCTGCCGGCCGCTACCACAAGGTGATTCTGTCCCGTTGTGTCGAAGTGCCTTTCGCGATC







GACTTTCCGTTGACCTACCGGCTGGGGCGTCTGCACAACACCCCGGTGAGGTCGTTTTTGTTGCAGTTGGGCGGAATCCGTGCTCTGGGTTACAGCCCCGAACTCG







TCNCGGCGGTGCGCGC






Clone Rv392




:::::::::::::Rv392SP6.seq:::::::::::::







GCAGTTGGGAATCGCTCTGCAGCAAAGGANTATTCTGCGCGACGTTCGAGAGGACTNTTTGAATGGACGGATCTACCTGCCGCGCGACGAGCTGGACCGATTAGGC




(SEQ ID NO. 545)







GTACNCCTCCGCCTGGACGACTCCGGGGCACTCGATGACCCCGACGGACGGCTCGCGGCACTGCTGCGGTTCANTGCCNACCGCGCCGCANACTGGTATTCGCTGG







GACTGCGGCTGATTCCACACCTCGACCGCCGCAGCGCTGCCTGCTGTGCGGCCATGTCTGGCATCTACCGCCGTCNGCTCGCCTTGATCAGACCATCGCCGGCGGT







CGTCTACCATCGGCGAATCTCTCTGTTCGGGACTGAANAANGCCCAAGTGGCGGCGGCAGCACTGGNCTCTTCGGTAACCTGCNGACCGCCCATTGGACCGCTACC







G







:::::::::::::Rv392T7.seq:::::::::::::







TTGATCTGGACGTCTGAGACGGTGATCGGNCCGAACCTGAATTGTCCGGTAATGCCCAGCGCAGAAAGCANGGTGGTGGCCGGGGCGGTGAANCCGGCGTCGGCGG




(SEQ ID NO. 546)







CACCGTCGAAGTCGATGTGGATTGCCGGAATGGGGATGTCCGGCACGGCGAAGCCGTAGTTCGCTTGTCCCGTGAGGCCCANGTGGATGGGGGGAAGGATCGTGGT







GTCCGGGATGATAATGGGGCCGATGCCGCCGGTTGAAGTCCAGTGGATCGGGAATTCGGGAATCGTGATGCCGACGTTCAGGCCGAACAGGCCCTCCAAGTTGCCT







CGCCACNAGATGCCGTTGCTGAAGTTGCCCGACATGAGGGCGCCGGTGTCCACATTGCCCGAATTGGCGACGCCGGTGTTGGC






Clone Rv393




:::::::::::::Rv393SP6.seq:::::::::::::







CACGTAGGCGCCGTCCATAAATNACTCCGCCGCGCTTCGCACATCCTCGTANCGATCCTTGGCGAGCAGGTCAACCGGGCGCTGCCCGTCNAGGAGCCGGTTTTTG




(SEQ ID NO. 547)







GCGTGCAGCCACTGGCCGACACCTCGGGGGGTAAGCGAATCCGAGAGCAGGAGGACNAGGTCACGAANCTGCGCCAGCCGGTCGTACCGCTCAGGGCGGATGTCGC







CGGTCCGCCACCCGCGTACCGCCCGATCGGACACCTGTATGACCGCGGCGACNTCGACCTGGGTGACGCCGAAGGGTTTCAGGGCATCNACNATCTCGCTGGCCTC







GACCGCCCGGTCCAGGGTGACCGCCATCGTGGTTCCTCCGCAACTTCCGGTTCTACTACCGTAAACGCTACCG







:::::::::::::Rv393T7.seq:::::::::::::







CGGGGAACGGTCCTCGCACACCTGGTTCGTGTTGCGGGAATTACTCGGACANCAAAACGTCAAGAACTACGACGGCAGTNGGACAGAANACGGCTCCCTGGTGGGC




(SEQ ID NO. 548)







GCCCCGATCGAGTTGGGAAGCTGATATGTGCTCTGGACCCAAGCAAGGACTGACATTGCCGGCCAGCGTCGACCTGGAAAAAGAAACGGTGATCACCGGCCGCGTA







GTGGACGGTGACGGCCAGGCCGTGGGCGGCGCGTTTCGTGCGGCTGCTGGGACNCCTCCGACGAGTTCACCGCCGGGAGGTCGTCGCGTCGGCCACCGGGCGAATT







TCCGGTTCTTCGCCGCGCCCCGGGATCCTGGGACCGCNGGCGCGCGCTGTT






Clone Rv396




:::::::::::::Rv396SP6.seq:::::::::::::







CTCAAGCTTTGTCCGACAAGCGTTCCCGGGCGGTCAGCAAGCGAACGTCGGTTGGCCCACTGCGGGTCGATATTGCCGCCAGGGA




(SEQ ID NO. 549)







:::::::::::::Rv396T7.seq:::::::::::::







CGTCAGCACGGCGACGTCGCGNTACGCCGAGCAGTTACACAATCGCTCTGCAGCAAACCAATATTCTGCGCGACGTTCGAGAGGACTTCTTGATTGGACTG




(SEQ ID NO. 550)






Clone Rv39




:::::::::::::Rv39SP6.seq:::::::::::::







CTGCATCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAA




(SEQ ID NO. 551)







TACTCAAGCTTCGCGCAGCGGCGGGTTGACCCGGTTCACGCCGTCATAGCTGGCCAATCTGGCATCGTCGATCANCATGTGGTGGGGGGTGACCTCGGCGGTGATC







GAAATACCCTGGTCCTTATCCCATTTCAGGATTTCGACGGTGCCCGCGGCCGACGCGTGACAGATGTGCACCCGGGCGCCGGCGTCACGGGCCAGCAAGGCGTCGC







GGGCGACGATCGATTCCTCGGCGGCCCGCGGCCATCCCGCCAGGCCCAGCCGCGCCGCCATGGGTCCCTCGTGCGCGACGGCGCCGACCGTCAGCCGGGGCTCCTC







GGCGTGCTGGGCGATCAGCACGCCCAAACCGGTG







:::::::::::::Rv39T7.seq:::::::::::::







CCGACGCGCACTACGTGCTGGTGTCCACCCGCGACCCGCACCGGCACGAGCTACGCAGCTACCGCATCGTCGATGGCGCTGTCACCGAGGAACCTGTCAATGTCGT




(SEQ ID NO. 552)







CGAGCAGTACTGAACCGTTCCGAGAAAGGCCAGCATGAACGTCACCGTATCCATTCCGACCATCCTGCGGCCCCACACCGGCGGCCAGAAGAGTGTCTCGGCCAGC







GGCGATACCTTGGGTGCCGTCATCAGCGACCTGGAGGCCAGCTATTCGGGCATTTCCGAGCGCCTGATGGACCCGTCTTCCCCAGGTAAGTTGCACCGCTTCGTGA







ACATCTACGTCAACGACGAAGACGTGCGGTTCTCCGGCGGCTTGGCCACCGCGATCGCTGACGGTGACTCGGTCACCATCCTCCCCGCCGTGGCCGGTGGGTGAGC







GGACACATGACACGATACGACTCACTGTTGCATGCCTTG






Clone Rv3




:::::::::::::Rv3SP6.seq:::::::::::::







TGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAAT




(SEQ ID NO. 553)







ACTCAAGCTTGCCGGGAGGGTGCATGGCCGACTCGGATTTACCCACCAAGGGGCGCCAACGCGGTGTCCGCGCCGTCGAGCTGAACGTTGCTGCCCGCCTGGAGAA







CCTGGCGCTGCTGCGCACCCTGGTCGGCGCCATCGGCACCTTCGAGGACCTGGATTTCGACGCCGTGGCCGACCTGAGGTTGGCGGTGGACGANGTGTGCACCCGG







TTGATTCGCTCGGCCTTGCCGGATGCCACCCTGCGCCTGGTGGTCGATCCGCGAAAAGACGAAGTTGTGGTGGAGGCTTCTGCTGCCTGCGACACCCACGACGTGG







TGGCACGGGCAGCTTTAGCTGGCATTCCT







:::::::::::::Rv3T7.seq:::::::::::::







GGAAACACCGNCGCCGTCGTGGCCACCAACACCGCGACCAGCACCGTGACCCGGACCGGGGTGCCGCGCGAACCGGTCTTGGCCAATTGCCGCGGCACCAAGCCGT




(SEQ ID NO. 554)







CGCGCGCCATGGCGAACAGCACGCGGCATTGCCCGAGCATCAACACCATCACCACCGTGGTAAGCCCGGCCAGCGCGCCGACGGAGATGATGCCGCTGGCCCAGTA







CACCCCGTTGGCCTGGAACGCGGTGGCCAGATTTGCCGGCCCGCGGCCCGGTACGGTCCGCAGTTGGGTGTATGGAACCATGCCCGACAGCACCACCGATACCGCG







ACGTAGAGAAGGGTCACGACCCCCAGCGACGCGAGAATCCCTCGAGGGACGTCTCGTTGAGGACGCTTGGTCTCCTCGGCCATGGTGGCCACGATGTCAAACCCGA







TAAACGCGAAGAACACGATCGATGCCCGGCCAGCACGCCGTA






Clone Rv40




:::::::::::::Rv40SP6.seq:::::::::::::







CCTGCTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGA




(SEQ ID NO. 555)







ATACTCAAGCTTGTCCTCGGGCGTGGCCTCGGCCAAGAAATCGTCGACGCCGGCCTCCTGTGCAATCGCCTTGGCGGTCGCCGGGTTGTCACCGGTGATCATCACG







GTGCGGATGCTCATTCGGCGCATTTCGTCGAAGCGTTCCCGTATGCCCACCTTGACGATGTCCTTCAGATGGACGACGCCGATGGCCCGCGCGCTGCTGTTATCGG







TCCATTCCGCAACGACTAGGGGTGTCCCCCCGCCGGAGCTGATGCCGTCGACAATGGCACCCACCTCCTCAGTGGGGTGGCCACCGTGATCGCAAAACCACTTCAT







CACCGCAGCCGCGGCACCTTGCGGATCCGAACGGATGCGCTC







:::::::::::::Rv40T7.seq:::::::::::::







TTCGTTCGATGGCGCCGCCCCGGCTACGGTTTGACCTGTGGGTGTCGAATTGGGGTCAAATTCCGAGGTCGGCGCGCTAAGAGTGGTCATCCTGCACCGCCCGGGG




(SEQ ID NO. 556)







GCCGAACTGCGCCGGCTCACACCGCGCAACACCGACCAGCTGCTGTTCGACGGCCTGCCCTGGGTATCCCGCGCGCATGACGAGCACGACGAATTCGCCGAGCTGC







TGGCTTCCCGCGGTGCGGAAGTGCTGTTGCTGTCGGACCTGTTGACTGAGGCACTACATCACAGCGGGGCCGCCCGCATGCAGGGGATCGCCGCTGCCGTCGACGC







ACCGCGGCTGGGACTGCCGCTGGCGCAAGAACTTTCGGCCTACCTGCGTATCTCGACCCAAGCANGTTGGCGCATGTGCTGACGCCGGCATGACTTCAACGAACTC







CCNTCCGACACGCCGAACGAAGTGTCGTTGGTGTTGCGTATGC






Clone Rv412




:::::::::::::Rv412SP6.seq:::::::::::::







GCGGCGAGTGTGGTGGGTGCCGAACACGAATCCAACGACGCACTGGCGGAGAGATACCACTTGCTGTACTGGAAGCACGTGCTGATGATCTCCCGTGGAATGTGCC




(SEQ ID NO. 557)







TCGCCGCCGTCTATCGAAAACAGTGAGCATGCTGCG







:::::::::::::Rv412T7.seq:::::::::::::







CAACCGCGCTCGGCGCGTCTGGGCCTTCCGCCGGCTCCGCCGACAATTCTATCTCTGGATCAGCGGGGCTCTCCGGGCCGGCCTCCGCGAACTCAACAGGCCGCGC




(SEQ ID NO. 558)







CTTCCGGCCGAAACATTCCCTAGCCATATATGATCGCACCTCGATACACGATCTGGCGGCAACACCGCAAAGCGTCCGACGGGCCCAACCTCCGCAATTCAGGTAT







CCGGG






Clone Rv413




:::::::::::::Rv413SP6.seq:::::::::::::







GAAGGTCGGCGAAGGTGTGGCTGGNTGCCGATCACGAATCCAATGATGCAGTGGTCGGAAGATATTAGCCACTTGCTGTTCTGGAGACAGGTGCTGATGATCTCCC




(SEQ ID NO. 559)







GTGGAATGTCCCTCGACTCCGTCTATCGAAATCTGTGAACA







:::::::::::::Rv413T7.seq:::::::::::::







TCCTGCGCTCTGGGCCATTCTCGGGTCTGCCGACAATTCTATCTCTGGATCTGTGGGGCTCTCTTGGCCGGCCTCNGCGATCTCTTCANGGCGCGCCTTCCGGCCG




(SEQ ID NO. 560)







AAACATTCCCTATCCATATATGATCGCACCTCTATACACCGTTTGGCGGCAACACCGCAAAGTGTCTGTCG






Clone Rv414




:::::::::::::Rv414SP6.seq::::::::::::







AGCTTTACGCTGGCGTATCAGCGTTGGGGCCGCTGCCATTTCGGTCGCCCAACGCGTTGCCAGCTCCCTGCGCTGTCAGGGCTTGCGCGCCAAACTGGCCACCGCA




(SEQ ID NO. 561)







ACAAACTTGGCTGAGCTTGATC







:::::::::::::Rv414T7.seq:::::::::::::







CTCTATCTGGCGTCACATTCGCAATCTTTAGATTGCAGATATCGATAAAATCACCCGCGCGACAAGACCGCCATGTCATCCTTTCGATGTTATTTCGCCGGCCTGG




(SEQ ID NO. 562)







GGAAAGCGCAACGACGTTGCCTACACGTTCCGCCGT






Clone Rv415




:::::::::::::Rv415SP6.seq::::::::::::







AGCTTTNCCTTGCATCTGCACCCCGATCCACGTCAGCCACGTCGGCGTTCTCCACCAAGAAGTTGCGGGCATTCTCCTTGCCCTGGCCGAGCTGCTCGCCCTCGTA




(SEQ ID NO. 563)







GGTGAACCAGGCACCCGACTTGCGGATGAGGCCCTGATCCACACCCATGTCGATCAGCGAGCCCTCCCTGCTGATTCCCTTGCCGTAGAGGATGTCGAACTCGGCC







TGCTTGAAGGGGGGCGAACAGTTGTGCACGACAACCCCTTCGGCGACGAGGGTGTGCAGTTCCTCGACCTCGAGGTCGAACGTTCGTGCCCGCCGCGTTGGCAGCA







CTTCTCGGATCACGGAATAGCGGANTTCTTCCGCCAGCATGTCGTGCAGGAATTTGTCATCCAGGGCATCCGCGAGCGCCTGCACGCG







:::::::::::::Rv415T7.seq:::::::::::::







ACTGTCNAGGGAATGCTTCGCAGCATCTACCTGCAGTCGCTTGTGCATAAGCGGACGGCCCNACCTGTTCGTGTTCCGGGACACCAGACGCGGGAGCACCGGCAGT




(SEQ ID NO. 564)







ACGGCGAAAGGTTTGAGCGGAAGGAGTTGCGCAAATCGGGGCGCCCCAACACCCGTCCGCAAGACGCGGTCAACGACCTGTTTCAGGCGATCAGGGTCACCGACTC







ACCTGCACTGAGAACAAGCGATCTGCTGATCTGCCAGAAGATGGACATGAATGTCCACGGCAAGCCTGATGGCCTGCCGCTCTTCCGGGAATGTTTGGC






Clone Rv416




:::::::::::::Rv416SP6.seq:::::::::::::







TGAATTATGATCCCGACACAACTGCATCANTTTAGCCGCGTCGNGATGCTATCCGCCGACGGTTTGGANCNGGTCCGTGTCGTTCGTGTTGATCTCACCCGAAGTT




(SEQ ID NO. 565)







GTGTCCGCCGCCGCCGGGGATCTAGCGAACGTGGGATCGACAATCAGCGCCGCCAACAAGGCGGCAGCGGCTGCGACCACGCAGGTGCTGGCCGCGGGCGCCGATN







AGGTGTCAGCGCGCATCGCGGCGCTGTTTGGTATGTACGGCCTGNAATATCCGGCGATCAGTGCGCAAGTTGCCGCGTATCACCANCAGTCCGTGCAG







:::::::::::::Rv416T7.seq:::::::::::::







AACGGGGACCNCAAGAAACCATTCAANAACGAGGGGTCGTCACCAACGTCGAAACCGACGGTTGCCAGCCGGCCCACGATATTGCGTGCTCGAGGGTCCGCTGTAC




(SEQ ID NO. 566)







CCTCACCGAACGTGAGTCCCACACCGCGGAGGCGGGCGACTCTGGCGTCGTTAGCAGCCGAGCTCAAGGTGTCCCGCACCACTGTCTCGAATGCTTTTAACCGACC







GGATCAGCTCTCCGCCGATCTACGTGAACGAGTGCTTGCCACGGCCAAGCGACTGGGCTATGCCGGACCGGATCCGGTGGCGCGATCGTTGCGGACCCGCAAAGCC







GGTGCGGT






Clone Rv417




:::::::::::::Rv417SP6.seq:::::::::::::







AGCTTTGGAGCCNCNCCGANCCNCCGGTACGCCCCGCCACCGCCGTACCCGGCACCCGACCCCTTTGAGCCGTTCGCCGTGGCCGCGGTGGANCTGGCCGACGAGG




(SEQ ID NO. 567)







GACTGATCGTGCTGGGCAAAGTGGTCGATGGCACGCTGGCCGCCGATCTGAAGGTCGGCATGGAGATGGAGCTGACGACCATGCCGCTGTTCGCCGACNACGACGG







TGTGCAGCGCATCGTCTACGCGTGGCGGATCCCATCGCGCGCCGGCGACNATGCANAGCGCANCGATGCTGAGGAGCGGCGCCGATGAGGATGAGCGCGCCGGAAC







CCGTTTACNTCCTGGGTGCCGGTATGCACCCGTGGGGGAAATGGGGTAATGACTTC







:::::::::::::Rv417T7.seq:::::::::::::







TTCTCNCATCGTTCGTACTNNGATGGGACGCTGCTGCCCGAGGCGATCCTGGCCAACCGGCTCTCGCCGGCGCTGACCTTCGGCGGGGCGAACCTGAACTTCTTTC




(SEQ ID NO. 568)







CGATGGGCGCTTGGGCCAAACGTACCGGGGCTATCTTCATTCGGCGTCAGACGAAAGATATTCCCGTCTACCGCTTCGTATTACGTGCTTACGCCGCGCAGCTGGT







GCAAAACCATGTCAACCTCACCTGGTCGATCGAAGGGGGTCGGACCAGAACGGGCAAGCTACGGCCACCGGTGTTCGGGATCCTGCGTTACATCACCGATGCGGTC







GACGAAATCGACGGTCCCGAAGTGTATTTGGTGCCGACCTCGATCGTGTACGAACAGCTGCACGAAGTGGAAGCCATGACCACCGAAGCCTATGGCGCCGTGAA






Clone Rv418




:::::::::::::Rv418SP6.seq:::::::::::::







TTCTTCCGGGTACCGCTGATCGGCGGCACCATCACGCACCCGGTGCAGGGCGAGGCGGCCGCCGGTGTGGTGTTGCTACGGCCGGCCAGCCCGGGTACCGGTGTGA




(SEQ ID NO. 569)







TCGCCGGTGGTGCGGCCCGCGCGGTGCTGGAATGTGCGGGGGTGCACGACATCTTGGCCAAGTCGCTGGGCAGTGACAACGCGATCAATGTGGTGCACGCCACCGT







GGCCGCGCTCAAGCTGCTGCACCGTCCGGAGGAGGTGGCGGCGCGCCGCGGTTTGCCAATAGAAGACGTCCCCCCGGCCGGGATGCTG







:::::::::::::Rv418T7.seq:::::::::::::







GTCGAAAGTGACCATCTCTACCTTGAGTGCCATACCGCCCGACCCTATGCCTCGGATAGCTCGGCGGAAAGAAACGCTTGCAGTGCCGCCGAATAGGCGGCTACGT




(SEQ ID NO. 570)







CGTGAGCGCCCATCAACTCTCGCGCGGAGTGCATCGCCAGCTGGGCGGCGCCGACGTCGACCGTGGGGATTCCGGTGCGCGCCGCGGCCAACGGCCCGATCGTCGA







CCCGCACGGCAGATCGGCGCGATGTTCGTAACGCTGCATAGGCACTCCCGCGCGCTGGCAGGCCAGTTGCGAAACGCCCCCGCCGGGTGCCTTCCGTCGGTTGGCT







TTACCGCAAATTTGGGGTTGCCCCT






Clone Rv419




:::::::::::::Rv419SP6.seq:::::::::::::







AAAGCCACGGAAACGATTGCCTACTGCCGAATCGGGGAACGGTCCTCGCACACCTGGTTCGTGTTGCGGGAATTACTCGGACACCAAAACGTCAAGAACTACGACG




(SEQ ID NO. 571)







GCAGTTGGACAGAATACGGCTCCCTGGTGGGCGCCCCGATCGAGTTGGGAAACTGATATGTGCTCTGGACCCAAGCAAGGACTGACATTGCCGGCCAGCGTCTACC







TGGAAAAA







:::::::::::::Rv419T7.seq:::::::::::::







TTTCGCCACCGCNAGGTCGTGCGCGTTCCAGAAAAGCGTGGTTTCGCCGGGCGCGAGGATTCGACGGTCCAACTGACCAGCCGGTCCCGCCACCCGTTAGGCAGGA




(SEQ ID NO. 572)







TCGCGGTGTCTATATGTTCGCCCTCGGCATAAACGCCATTGCTGCGGTGAAAATCGGACATCTCGCCGATTGCCACGTCTACATGATCCGCTTTGTCCCGCGCCGG







GTCGTTGACAAACGCGATGTCNGCCTCCTGGGAAGCGGTGGC






Clone Rv41




:::::::::::::Rv14SP6.seq:::::::::::::







TCGCCAAGTGGATTCGTGCTCACCNACGAGATCCGTGGTCGGATCCGCNGCTGCGGCGGGCTGCGACCCTGCATCTCGGCGGCACCCGTGACCAAATGGCGCGCGC




(SEQ ID NO. 573)







CGAAGCAGACGTCTCGGCGGGACGCCACGCCGACTGGCCGATGGTGCTGGCCGCGTGTCCGCNCGTCNCCGACCCCGGCCGCATCNACCAAACCGGCCGCCGTCCG







TTCTGGACCTATCCCACGTGCCNTCGGGGTCCACGCTCGACGCGACCGANAACGTAACCAGCGTCCTCGANCGGTTCGCCCCCGGCTTCCGTGACATCGTGGTGGC







GGCCGCGCCGT







:::::::::::::Rv41T7.seq:::::::::::::







GTACCGTCACCATGATCGCCCCCATCGGCATCGGTGAGCTGATAGATCCCAGCCGGTTTCGCCAACCCCGGAGCGATCTTGGCGCGCTGCTNGTNGTCNCTGANAC




(SEQ ID NO. 574)







NTAGCCACCAACAGAGCCCGGTGTGCGACAAGANGACTGATCGGATCTCTCCGGACACNTCGAGGGGGTCNTCAGGAGNCCGGGCGCCACCCCGAGGTAAGCCTCC







GCCCAGCCTCACACCGCGACCGGGTATCNCAAGTCGCGCAATAANCCCACCACCTCCTCGGACCCCACGTTGTATGCGGCTGGGT






Clone Rv42




:::::::::::::Rv42SP6.seq:::::::::::::







ATACTCAAGCTTAGACCTCACTGATGTGGCGGGACGCGGGAGATAACCGCGGTTCGAGCCGTTCAACAGTGGTGGTTCCCACACCAGTTGTTTGCCTTTGCGAAGT




(SEQ ID NO. 575)







AAAGCGATTCGATTTGCTCGAAAAGAGGGCTGGCTGCTCGTGAGGGACATCCATGGCCGATACCTCAGCGATCTCAACGGTCAAGCGACTGCATGTTTGGCGCAAG







GTATCGCTAAGCATAGGTTCGTGACGGATTTGACAGCAAGAGCTTTCCAAAGATTGCTGTCCACATANTGATTCGCATCTCTACACCTCTTCGCCGGTGCTGTCAA







GAGCCATTCGAATCAGTTATCTCGCTCGTGCTTGGAANAAATTTTCCCAGCCTGCGTTGGACAAACCGCGTCGCCAAAGCGGT







:::::::::::::Rv42T7.seq:::::::::::::







AGCTTCCCGAGAAACAGTGCATTCCCTAAGCAGCCCGTTGTCACGCCGATGAGTGAAGAGTGCACGCAATCGCCGGAATCCGGCAAAGCCCTGCACAAGCGAAATC




(SEQ ID NO. 576)







AACCCGGAGGCTGACAAGGCAACGTCGGTGATCCGTACCGCCTGGTTGGACAAACGGCAGAAGGCGGCCTCGTCCGGTCCATCTACGCCGAGCACACTGGTGATAG







CGCGCATCGGCATCGGTGCGGCCACGGTGGAGACGACGTCCGCGGGCGTCTGGGTCAGTAACCCGCCGACCAGTTCTCGGGCAAGCTGGTCGACCATCGGGCGCCA







CGTCTCCAACGCGCCACGCGCCATACCTGGTGCCAGTTGCTTGCGCATCCGGGTGTGCGCCGGCGGATCGGACGTCGCAGAAACGCAGCCACCCCGTGAGAAGTGA







CCCACGGCGCTGGACACGTGTCTGGTTAC






Clone Rv43




:::::::::::::Rv43SP6.seq:::::::::::::







CGGCCGGGATGTGCGCAATGGCAGGTTGTCGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGAAAGTCCGTTGGGTGCAATGATGTAN




(SEQ ID NO. 577)







CGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCTTGGCGTTGACACCATCTTTGTCATGGCGGC







GAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCNGGTGGTAATCCGGCCATGCGCGTTGCGTCCACCGCGACCGTGCAGCGGGCGCACCAG







CGACNTCTCCGGGGTTGACCGGGTGATCTCGGCGAAATCAGATACGCTGGCGCCGCGACGACCAGGCGTCGTGGGCTTGTACTTGCGAATTGCCATGGTCTAATCA







GGTCTTTCTCTCACCTCTCGTCGCCGGGCTAGGGCGCATTGCCTGCTCCT







:::::::::::::Rv43T7.seq:::::::::::::







TAGCGGTGTAACCAACTCCCGGGTCACCACCCGCAAACCTCTTGCGGCAACAGCACCGTCGACGCGTCAACCGGGCTGCCCGGAATCCTGTGGATGGGCATCGAGT




(SEQ ID NO. 578)







GCATGGTCACGACGTCCCCGACGCGGCCGGTGGCAACGACAAGTGGCCCGGATGCACCACAAATGACGGCCGCACACCGGTGGGGACGGCCAGCACGAGAGCCGTG







TCGCCGAAGTCGACGCTAATGCCGTAGGCATTGGCCGTCACAACAGGCGACGCCCCGCGTACCACCGAGTCCACGGNGGTTGGGCGGTCTCCTCGGCCAACCAGGC







GTGAACCCGGCGGATCCGAATGCAGCAAGACCCGTGGGC






Clone Rv44




:::::::::::::Rv44-2ndSP6.seq:::::::::::::







CCATTGGTCGGTGTGCGCATACCANTACNACGCGCCGGGCACCTGACGCGGCGGCCGCAACCATTCGGTGGCCATCGCCATCGTCTGCCACCCGGTCAACGGACGC




(SEQ ID NO. 579)







ACCTTCTCCTGGCCGACCTAGTGCGCCCACCCGCCGCCGTTGCGTCCCATCGATCCGGTCAACATGAGCAGCGCCAACACCGAGCGGTACATGACATCTGCTGTGG







AACCAGTGACANATTCCGCCGCCCATGATGATCNTCGACCGTCCTCCGGATTCGGTC







:::::::::::::Rv44-2ndT7.seq:::::::::::::







GCCGGCCTGGTCAAAGGGGCGTCCGAAGGANCCGGGCTGGGTAACAAGTTCCTGGCTCATATCCGCGAATGCGACGCCATTTGTCAGGTGGTGCGGGTGTTCGTCG




(SEQ ID NO. 580)







ACGACNACGTGACTCATGTCACCGGACGGGTCGATCCCCAGTCCGACATTGAGGTCGTCGAGACCGAGCTGATCCTGGCAGATCTGCAAACCCTGGAGCGGGCCAC







GGGCCGGCTGGAGAANGAAGCNGCACCAACAAGGCGCGCAAGCCGGTCTACGACCCGGC






Clone Rv45




:::::::::::::Rv45SP6.seq:::::::::::::







GATCCACTGACCACGATGACATATCGAAATGCTCGACGATTCCGATGGCGATCAAGGCCACGATGCCCTGGCCGTTGGGCGGTATCTGGTGGATGGTGTACCCGCG




(SEQ ID NO. 581)







GTAGGTTCCCGTGATCGTGTCGACCCAGTCCACGCGATGGGCGGCGAGGTCGTCGGCACGCATCACCCCGCCGTNTGCCGCCGAGTGCGCCTCGAGTTTGGCGGCC







AGCTCTCCCCGGTAGAACTCTCACCGTTGGTCGCCGCGATCTTCTCTANCGTCGCCGCGTGGTCAGGAAAGGTAAACAGCTCACCGGGTTTCGGCGCTCGTCCGCC







GGGCATGAACGCATCTGCGAATCCGGGCTGGGATGCGAACAACGGACCTGTGCCG







:::::::::::::Rv45T7.seq:::::::::::::







TCTACTGCCGAATCGGGGAACGGTCCTCGCCCACCNGGTTCGTGTTGCCGGAATTACTCAGGACACCGAAACGTCGAGAACTACGAGCGGAGTTGGACANAATACC




(SEQ ID NO. 582)







GCTCCCNGGTGGGCGCCCCCATCGANTTGGGAAGCNGAAATGTGCTCTGGACCCCACCCAAGAATGACATTGCCGGCCGCCCTCCAACTGGAAATAGAAACNGTGA







TCACCCGCCGCGTTCTTGGAAGGAATGGCATGCCCTGGGCCGGGCGTTCCTTCCGCTGCCGGACTCCTCCCACCAATTCACCGCCGAAGGCGTCCCGTCTGC






Clone Rv46




:::::::::::::Rv46SP6.seq:::::::::::::







ATACTCAAGCTTCTGTCACCGAAATCCCGCATGGGATAACGGGTTTAGATTTCGACAACGGGACCGTGTTTCTCAACAAGCCGGTCATCAGCTGGGCCGGCGACAA




(SEQ ID NO. 583)







CGGTATCTACTTCACCCGCTTTCGCCCGT







:::::::::::::Rv46T7.seq::::::::::::







CTGGCTCAAGCGCTCGGCGCGCAGGTGAACTCGGACCGGCTCGACGTCGCCGAACGCGAGGCGGTGCTGGCCCACGCCGACGCCGTCGTCGCACATATCGGCACCG




(SEQ ID NO. 584)







TGCACAAGTCTACAACAACGCCGGCATCGCGTACAACGGCAACGTCGACAAGTCGGAGTTCAAGGACATCGAGCGCATCATCGACGTCGACTTCTGGGGCGTCCTC







CACGGGCCC






Clone Rv47




:::::::::::::Rv47SP6.seq:::::::::::::







CCGCCCTCCGCATTATGGGTCAAGAACCATCGGGTCGGACTTCTGGGCTTCCAACGCTCGCGCCGTCCCN




(SEQ ID NO. 585)







:::::::::::::Rv47T7.seq:::::::::::::







CCGTGGCACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAAGCCGAACGCGAAACGAGAAC




(SEQ ID NO. 586)







GTGTTCCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCACGCAGCACCGGGACGGATGTCGGCCACCACGCCCATCTGGGGTGGTAGCGGG







GAAATACCGCTAACGCGGCTCCGGTGCCG






Clone Rv48




:::::::::::::Rv48SP6.seq:::::::::::::







TACTCAAGCTTGTCCAAATATCGAAGCGTCGGGTCGCGAGGCTCGGTCGGCAGCTCCAGCAAAACCCGCTCCACCCCTAGATGCCGGTATCCCTCAAGGTCTTTAT




(SEQ ID NO. 587)







CCGCCGCTTCACCCCACTGGCACACGGTCACCGGCACGTCGCCCCCGGCCATGGCGCGCAACCGCTGAAGCGGACCCGACAGCCGCTGCGGTGATGGACTGATCGC







GATCCACCCGGCATTGAGCCGGGCTATCCGCGGGAAGTTCGCCGGTCCCCCGCCCACATACAGCGGAGGATAGGGCTTTGTCACCGGCTTCGGCCAGCAGTAGATC







GGATCGAAGTCCACATATGTCCCATGGAATTCCGCCTGCTCCTGCGTTCAGATCTCGATTATCGCGCGCAACCGCTCATCGATCACACGTCCGCGCACCGCAGGGT







CCACACCATGGTTGGCGACTTCTTCGCGCAACCAGCCACACCCACGCCGAAACGAAACCGTCCCTGCG







:::::::::::::Rv48T7.seq:::::::::::::







CAGGCATCGAAGCTTGGCCAACTCCTCATCGGACTTGAAGGTGCCGTCCTCGTTGGCGGCCCTGCTCCACGGCACGTTGATGGCACCAGGAATGTGTCCGGGCCGC




(SEQ ID NO. 588)







TGGCTTTGTTCCTGCGGCAGGTGCGCGGGGGCCAGGATCTTGCCGGAGAACTCGTCGGGAGAGCGCACGTCGATGAGGTTCTTGACGTTGATGGCCGCCAGGACCT







CGTCGCGGAATGCCCGAATCGTGTTATCCGGCGGGGANGCGGTGTAGGAAGTCACCGGCCGGCTGACCGGGTCGCTGGACAGCGGGCGTCCGTCGAGCTCC






Clone Rv49




:::::::::::::Rv49SP6.seq:::::::::::::







ATACTCAAGCTTCAAAACAGGCCTGTTGTGGGCGCACCCGGCTCGCCGAGTTCTGCACGCACCGCCTCAAGTGCGGCCCGCACCGCCGGCATCTCCCGGTCACGCA




(SEQ ID NO. 589)







GGGCCGCGGCCCGCGCCGCAGCGACGGCGTGTTCGCGCAGTTCGCCGTCAATGATGCTGACCTGATCGGCCACCCGGGCGGTCTCGGCGTCGTCCCGTTCACTAAT







CGCGGTGCTCAGCAGCGTCTCGACAGCCACCACCCGAGTGGAGACCAGATGCNCCACCACGGACCGCAGCGATGCCAGTCACCTCACCCGTCC







:::::::::::::Rv49T7.seq:::::::::::::







CAGGCATGCAAGCTTTGCAGTTGCTGAGTAATGTCGGCCAACGTCACCACAATCGCGATGAATTCAATCATGCCGCCCAGGGCGGCCAACCCAATGGTGGCCGCGA




(SEQ ID NO. 590)







GCGGCAGCTCGATCGCAGCGCGGAGGTTGCCGGCCGCCAGTTGATTCACGAACAGGGTGAGGTCATAGGCGGGCAGGATAGTGACGAAGGCAAGACCTAGATCTGC







CGTCGGAAGAAGAATCGAGTATCCGGTCGACACAACGGAAGCGAAAGTGTCCGCGATGTTGATGAGCGTCGCCGGTTGTGGCGGCGGTGGCGGCGGTAGCACCGTC







CGCACATACCGCGGGAACGCGGGCATCCGAATTTGGGGCAGGGTGTTCAAGGCGGCTGGCAACTCACCATGAATCT






Clone Rv4




:::::::::::::Rv4SP6.seq:::::::::::::







CCGGCTCGTATGTTGTGTGGAATTGTGACCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCA




(SEQ ID NO. 591)







AGCTTGGCCGCAGGGCCGAGTCGATTGGTCGCGGTCGCCTCGACAGTTAGCTTATGCAATGCTAACTTCGGGGCAAAGTTCAGGCGGATCGGCCGATGGCGGGCGT







AGGTGAAGGAGACAGCGGAGGCGTGGAGCGTGATGACATTGGCATGGTGGCCGCTTCCCCCGTCGCGTCTCGGGTAAATGGCAAGGTAGACGCTGACGTCGTCGGT







CGATTTGCCACCTGCTGCCGTGCCCTGGGCATCGCGGTTTACCAGCGTAAACGTCCGCCGGACCTGGCTGCCGCCCGGTCTGGTTTCGCCGCGCTGACCCGCGTCG







CCCATGACAGTGCGACCCTGNACCGGGCTGGCC







:::::::::::::Rv4T7.seq:::::::::::::







GTGTGCTGTCAATTCAGAGCTGAGCCTGATGCACTCAACTTACTGAGCATGCTAACGCTGGTCGTGCGGGTCTTGTTCCCGCGTGTCGGCAGGGCACACGCTCGGG




(SEQ ID NO. 592)







GCGTAGCTGGGAGAGGCCCCGGTCAAGCCCGGAGAGCAGTGCTCAGTCCGCCAGCTTGACCGACTTTCGATGAGAACGCGCTTCTCGCCGTATTGAACTGGCGTGC







TGACGGTCGCTGAGCAGCGCTCGCCGAGTGCGGCCGCTGATTCTTTCATCGAGCCAGGAGGCGCATTCGTGTTCGGCCGCCTGCGGGTCGGCCCCATCGTCGACGC







GATCCGTCACCCACTCCTCGATCAGGTCTGCCTCATCGAACGGGCCAACGGTGCTGTCGGAGTAAGTGTGCGTGGGCACGCGAGCCGGGTGCTGTGGTACACCCAC







CGTTGCATGAACAA






Clone Rv50




:::::::::::::Rv50SP6.seq:::::::::::::







ATACTCAAGCTTCACCAGGCGCCGGCGGGCCGCGGCGCCAAGCCAGGCAGCCGCGCTCGGCGCGTCGGGGCCTTCCGCCGGCTCGGCCGACAGTTCGATCTCTGGA




(SEQ ID NO. 593)







TCGGCGGGGCTCTCCGGGCCGGCCTCGGCGACCTCAGCGGGCCGCGCCTTCCGGCCGAACCATTCCCTAGCCATAGATAACCGCACCTCAATGCACGGTTTGGCGG







CAACCCGG







:::::::::::::Rv50T7.seq:::::::::::::







AGCTTCCGTCACGACCCGCCCTCGCCGGTGCCGGCGCCATCGGTCATCGGATCTCATGACGACGTCACGTAGGCCCGCTAGCCGCGAGCGGGCGCGGTCAACTGGC




(SEQ ID NO. 594)







GAGGCGGCGGCGACGTGACTGAGCTGGCCGAGCTGGACCGGTTCACCGCGGAACTACCGTTCTCGCTCGACGACTTTCAGCAGCGGGCTTGCAGCGCGCTGGAACG







CGGCCACGGTGTTGCTGGTGTGCGCGCCGACCGGCGCTGGCAAGACGGTGGTCG






Clone Rv51




:::::::::::::Rv51SP6.seq:::::::::::::







ATACTCAAGCTTGCCGGGACCGCGGAACAGAACCGGCGGTTCCTACCGCGGTGTGCGGCCGGCGCGATATCGGCCTCCCGACTAACCGAACCCGATGTGGGCTCC




(SEQ ID NO. 595)







:::::::::::::Rv51T7.seq:::::::::::::







ACGTTGGCTCTGCCGGAACGTATTTCCAGCGGCACGCATTCGGCGTGGGTGCCGGGCGCCGAGTTGCGTCGCTGGGATCACGCAGCAGTCGCCGGCGGCTGCCGTC




(SEQ ID NO. 596)







GGGCTATGAATTGCACCGAGCCGGAAAATCCNCAC






Clone Rv52




:::::::::::::Rv52SP6.seq:::::::::::::







ATACTCAAGCTTGTCGTATTCCGTGGCACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACCCAA




(SEQ ID NO. 597)







GCCGAACGCGAAACGAGAACGTGTTCCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCACGCAGCACCGGGACGGATGTCAGCCACCACCC







CCATCTGGGGTGGTAGCGGGGA







:::::::::::::Rv52T7.seq:::::::::::::







CGTTGGTAGCCCGATATGCATAGTGTATCTTACTGAACATGATTTCCATTATGGAGCCCGGGGTGCCGGCAGCGCGAACGGTGCGCCGTCAGACGCGGGCGGCACT




(SEQ ID NO. 598)







GACCAGGGTGTTGCGGGCGAACATCGGCCCGGCTTCGGATTCCGGTCCGGGTACCGGGCGACCCACCGCTTCGAGGTC






Clone Rv53




:::::::::::::Rv53SP6.seq:::::::::::::







ATACTCAAGCTTGGCCAACTCCTCATCGGACTTGAAGGTGCCGTCCTCGTTGGCGGCCCTGCTCCACGGCACGTTGATGGCACCAGGAATGTGTCCGGGCCGCTGG




(SEQ ID NO. 599)







CTTTGTTCCTGCGGCAGGTGCGCGGGGGCCATGATCTTGCCGGAAAACTCGTCGGGAGAGCGCACGTCGATGAGGTTCTTGACGTTGATGGCCGCCAGGACCTCGT







CGCGGAATGCCCGAATCGTGTTATCCGGCGGGGAGGCGGTGTATGAGGTCACCGGCCGGCTGACCGGGTCGCTGGACAGCGGGCGTCCGTCCAGCTCCCACTTCTT







GCGGGCGCCGTCCAACNACTTGACTTCTCCTGG







:::::::::::::Rv53T7.seq:::::::::::::







ATATCTTAAGCGTCGGGTCCCGAGGCTCGGTCGGCAGCTCCAGCAAAACCCGCTCCACCCCTAGATGCCGGTATCCCTCAAGGTCTTTAGCCGCCGCTTCACCCCA




(SEQ ID NO. 600)







CTGGCACACGGTCACCGGCACGTCGCCCCCGGCCATGGCGCGCAACCGCTGAAGCGGACCCGACAGCCGCTGCGGTGATGGACTGATCGCGATCCACCCGGCATTG







AGCCGGGCTATCCGCGGGAAGTTCGCCGGTCCCCCGCCCACATACAGCGGAGGATAGGGCTTTGTCACCGGCTTCGGCCAGCAGTAGATCGGATCGAAGTCCACAT







ATGTCCCATGGAATTCCGCCTGCTCCTGCGTCCAGATCTCGATTATCGCGCGCAACCGCTCATCGATCACACGTCCGCGCACCGCAGGGTCCACACCATGGTTGGC







GACTTCTTCGCGCA






Clone Rv54




:::::::::::::Rv54SP6.seq:::::::::::::







ATACTCAAGCTTGTCGCGGTAAACCCGCAGCAGGGCGGTGGGTGCGGTGTCAAAAACAACCACACTTCTTTGCGGTTCGGTGATCTCGACACCGGCCGCGAGCCGA




(SEQ ID NO. 601)







CCACCATGCGCGCGTAAATCGGCGATCAGCGCGTCGGCTATCGCCTGGGTGCCGCCCACCGGAATCGGCCAGCCGACCGAATGGGCCAGCGTTGCCAGCATCAGTC







CGGCGCCGGCCGACACCAGTGACGGCAACGGTGAAATCGCGTGGGCGGCAACGCCGGTGAACAACGCGCGGGCATCCTCGCCCGCCAGCGACCGCCAGGCAGGGGT







GCCCTGGGCCAGCATCCGCAGCCCGAGACGCAGGACCGAGCCCAGTGCAGTAGGCAAAGACCGCTTGTCGGAGACATGAACTCCACGACCGT







:::::::::::::Rv54T7.seq:::::::::::::







AGCTTATTGAACCGCGGGTCGCAGGCAAAGTGGACCTCATAACGACTCGGGTCCAGCGACCGCGCCAACACGAACGGCCGGACGACGTGGGCCAGGGTCGCGGCCT




(SEQ ID NO. 602)







CCCCTACAAACAGGATCCGTTGCCTGCGAGCGACAGGCTCCGGTGCGGCGTTGGGCGCCGTGCTCGTCCCAGCGTCCGGTCCCGGGTCGCCGGCGACGCTTGTTTC







CTCCATACTCGCCCCCTAATCTCGAGGCAGCCCGTACCCGCAGGCAACCTCCCAAAAATGCAATCCCCCAAAATGCAATGCGTCGAGCTATTTCTCACACCGACCG







CTAGTTGCGGATCAGAAATCCGTTGGGCGCGGAAGTCCAGCCGAATTTGTTCTCCCGCTCCGCATCATGCTTGTAATCGTTTGGAAATTCATCCTCATATGCCTCG







ATCGCTTCATAGGGTCCAGGCCAAACCGGGCA






Clone Rv55




:::::::::::::Rv55SP6.seq:::::::::::::







CTTCCGGCTCGTATGTTGTGTGGAATTGTGAGCGGATAACAATTTCACACAGGAAACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATAC




(SEQ ID NO. 603)







TCAAGCTTGGCCACCTCGCGGTGTGTGGTGGAACCCATCTGAGCAGTGTGCCAAACCGGGGCAGACAGCTCCCAATTGACGTGAGCCCGCTCACTTGCTGGGTAAG







CGTCG







:::::::::::::Rv55T7.seq:::::::::::::







TAGCGCCCCCTCCCGGGCGGAGCTCCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCGGCGTTAGCGCCGGA




(SEQ ID NO. 604)







TTCCACCACATCCCCTTGCGAAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTAC







TCGATGTGCGCGACCTTGGCGTTGACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCC







GGCCATGCGCGTTGCGTCCACCGCGACCGTGCAGCGGGCGCACCAGCGACTTCTCCGGGGTTGACCGGGTGATCTCGGCGAAATCAGATACGCTGGCGCCGCGACG







ACCAAGCGTCGTGGGCTTGTTCTTGCGAATTGCATGTCTAATCAGGTCTTTCTC






Clone Rv56




:::::::::::::Rv56SP6.seq:::::::::::::







TGAAACTAATATAATACTCAAGCTTGCCAAAGAAGACCTCGTCGACCAAGCAGGACGCGACCGTCGAGGTGGCGATCCGGCTTGGCGTCGACCCGCGTAAGGCAAAC




(SEQ ID NO. 605)







CAGATGGTTCGCGGCACGGTCAACCTGCCACACGGCACTGGTAAGACTGCCCGCGTCGCGGTATTCGCGGTTGGTGAAAAGGCCGATGCTGCCGTTGCCGCGGGGGG







CGGATGTTGTCGGGAGTGACGATCTGATCGAAAGGATTCAGGGCGGCTGGCTGGAATTCGATGCCGCGATCGCGACACCGGATCAGATGGCCAAAGTCGGTCGCAT







CGCTCGGGTGCTGGGTCCGCGCGGCCTGATGCCCAACCCGAAAACCGGCACCGTCACCGCCGACGTCGCCAAGGCCGTCGCGGACATCAAGGGCGGCAAGATCAAC







TTCCGGGTTGACAAGCAGGCCAACCTGCACTTCTC







:::::::::::::Rv56T7.seq:::::::::::::







GCTGAGCTCCACGGCGTGGATCAAGGTACCGGCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGATGTCGGCGTTAGCGCCGGATTCCACCACATCCCCT




(SEQ ID NO. 606)







TGCGAAAGTCCGTTGGGTGCAATGATGTAGCGCTTCTCCCCATCGAGATAGTGGAGCAACGCAATCCGTGCGGTACGGTTCGGGTCGTACTCGATGTGCGCGACCT







TGGCGTTGACACCATCTTTGTCATTGCGGCGAAAGTCGATCATCCGGTAAGCGCGCTTATGACCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCGTTGCG







TCCACCGCGACCGTGCAGCGGGCGCACCAGCGACTTCTCCGGGGTTGACCGGGTGATCTCGGCGAAATCAGATACGCTGGCGCCGCGACGACCAGGCGTCGTGGGC







TTGTACTTGCGAATTGCCATGTCTAATCAGGTCTTTCTCT






Clone Rv57




:::::::::::::Rv57SP6.seq:::::::::::::







ATACTCAAGCTTGTTGGTGACCTCGCCGGCGAACAGTTCTCGCACGATTTCCGGATTAGCGGGACTGGTCACCAGTTGGGTATGCGGGAAGGCGCTGACGTTCGCC




(SEQ ID NO. 607)







GCGATTAGCTGTTTGATGGACGCGGCGGTGATGTCCTGATCACGGAACTGGCTGTAATAGCCCAGGGTCGCCACGCTTCCATCCGGGCCCGGACCCGGC







:::::::::::::Rv57T7.seq:::::::::::::







GATGATCGCCGGTGCCACCCCGATCCGTGCCTCGGTCAGCGCGAACGTGCTTTCCGGTCCGGCGACCACCATGTCGCACGCACCGACCAGGCCGAACCCGCCGGCC




(SEQ ID NO. 608)







CGCACATGCCCGTTGATGGCGCCGACCACCGGCAGCGGCGACTCGACGATGGCGCGCAACAGCGCCGTCATTTCCCGCGCCCGCGCCACCGCCATCCGGTACGGAT







CACCACCACCTCCGCCGGCCTCGCTGAGGTCC






Clone Rv58




:::::::::::::Rv58SP6.seq:::::::::::::







ATACTCAAGCTTGCCGCAATCGAAACCAACCTGTTTGTGCCGCAAGAAATTACGCCGTGGCCCGGCGCCGATCAAGAAACGCCCCGGCGCGCGGCGGTGTCGTCGT




(SEQ ID NO. 609)







ATGGCATGACGGGCACCAATGTGCACGCCATTGTCGAGCAGGCACCGGTGCCAGCCCCCGAATCCGGTGCACCAGGCGACACCCCGGCCACACCCGGTATCGACGG







CGCGCTGCTGTTCGCGCTGTCGGCCAGCTCGCAGGACGCGCTGCGGCAAACCGCCGCGCGGCTGGCCGATTGGGTCT







:::::::::::::Rv58T7.seq:::::::::::::







TTGGCGGGTTGGCCACANCANCCCGCCGGTGACGGCGACGATGCTGGGCTGGTTGCGGCCCTGCGCCACCGCGGCTTGCATGCTGGTTGGCTGTCTTGGGACGATC




(SEQ ID NO. 610)







CCGAAATAGTCCACGCGGATCTGGTGATTTTGCGGGCTACCCGCGATTACCCCGCGCGGCTCGACGAGTTTTTGGCCTGGACTACCCGCGTGGCCAATCTGCTGAA







CTCGCGGCCGGTGGTGGCCTGGAATGTCCANCGCCGTTCACCTACGTGACCTTGATGGGATCCGGGGGNT






Clone Rv59




:::::::::::::Rv59SP6.seq:::::::::::::







NCGTGGACACCGGTGTCGANCGCCACCAGCCGCATGTCTGCANGTCNATTCCGTCCTCGGCAACATCTTGAATGCCGAGCAGCGCCTGGGCGTGATCGGCAACCGG




(SEQ ID NO. 611)







GGATGACCGCTCGCCGATCCGCTCGACAATCCCGGCGGCACGTGACATGCCGGCGGACGGCTCGACGAGCTGGAACTTCAGCGACGACGATCCGGAATTGATCACC







AGCACGGTGCTACTCATGGACCCCTGCGCCTGAATCCCGTGATGGCCACGGTGTTGACTATTCGTCGACAGTGCACCCGAGATAGTCTTCACGGCTGCGT







:::::::::::::Rv59T7.seq:::::::::::::







CATGTATTGCCGTGCTCACGGCGCCACGCTCGATGGTTTCTCGAAGTCTCCGGGCTGGTGTACAGCTTCTCGTTGATCTCGTTCGCCACGCCGTCCTCTTCCCGCC




(SEQ ID NO. 612)







GACGACCCGATCTCGATCTCCANAATGATCTTGGCGGCCGCCGCCGCCTTGAGCAGCTCCTGGGCGATGGCCAGGTTCTCATCGATGGGCACTGCCGACCGTCCCA







CATGTGCGACGGAACAAAGATGTCACCTTGCTCACGCGTGCGCNAGATCNCANAAGGGCCGGACATACTGTCNACTTGTCCTTGGGCAGTGGTCCGTGTCAGCCCA







CGTGACGGGTACTTGGCGCGATAACGTGGTG






Clone Rv5




:::::::::::::Rv5SP6.seq:::::::::::::







GCCACCACGACCCGGCCGTAACTCTGCTCACGGAAATGCGGCCAGGCCGCGCGTAGCACGTGGTATCCGCCATAAAGGTGCACCTTAAGCACGGCGTCCCAATTCT




(SEQ ID NO. 613)







CGAACGACATCTTGTGGAAGGTGCCGTCGCGCAAGATCCCGGCGTTGCTCACCACACCGTGCACGGCGCCGAATTCGTCAAGCGCGGTCTTGATGATGTTCGCTGC







GCCGTCCTCGGTGGCGACGCTGTCCTTAGTTGGCGACCGCCCGGCCCCCCTTGTCGCGAATCTCGGCGACGACCTCATCGGCCATCGCCGAACGGCGCCCGTGCCC







GTCGCGGGCGCCACCGAGGTCGTTGACCACGA







:::::::::::::Rv5T7.seq:::::::::::::







CAGGCATGCAACCTTTGTCCACACGGCGTCTACTCCGTGCAAGGTCCGACCGCTTCCACGTCCCGCCGTGACGGTGCTCCATCTCCCTCAGCAACGCGTGAAGTGG




(SEQ ID NO. 614)







TCCGATCCCGCGGCTTCAGG






Clone Rv60




:::::::::::::Rv60SP6.seq:::::::::::::







GTTGAGACGCAACCAGCGCACAACGACGATTTGGCGTAGCGGCGGACGTCTGCTCGATTCGATCACGTCGCGCTCGCATCGAGCATGGCCCGCGACGCTACACGAT




(SEQ ID NO. 615)







CGCCGTCGTCGATGACACGACCGAGCCGTACGCCGGCCGTAAGCCGCGCCAGGATTCGGCGAAAAACGTCTACGTGGCGGGTGTACTGGGTGTCGAATGATTCGTG







GGGTGCGTATGCGTCCTGCAATCGTCGACATAGATCCGTCGCCGCATCGCGTCGACAACTCCGGGTGAGTGGAATACACTTGCCGATCACGCGACGTGCGCGGATC







GATGCCGACCGAAATACGACCACATGGCTCTTGTTGCNCAGTGTTGGCGGCATCAAATACCCTCAGTGCCGTCCGAC







:::::::::::::Rv60T7.seq:::::::::::::







TTNCCGCCTTNACGCCTACTCCNAGACGATGCTCGACGCGTGTGAGCACACGGCGCTGCTGTAGACGGCACGGCGCAGCTGGATCGCGCTTGGTGCACCCAAGCCT




(SEQ ID NO. 616)







CTACGCGCGTCGCTGCGTCGTCATCGGGTACCGAACATATTCCGGTCGTTGCGCAGAGTGTGCATGTGCGGCTCTTGTGAACGAACATAGCAAAGCGTATATGTCT







GTGGCGGCTCTGCAGATATCGCGATAATACGTATATACATAAGGTGGCGCGCGATCTATCGGTATATCCGTTATGGCGGACGTGCGTGAGCGTGAGTCGCGGCGCA







TCGCGCACTTCGCGATCGCGTGACTGGTCCTCGCGACTGCGCGCATGCGTAGC






Clone Rv61




:::::::::::::Rv61SP6.seq:::::::::::::







GGTGATGACGCACTTGCTTCGAATGAGTCATTGACTACTCCCGTGGTTGTCCTGCGATGGTGGAGTGCCGCGCAGCCTTGCCCGANGTCGCGATCGCGTCGCGGGC




(SEQ ID NO. 617)







TTCGGGGAGCAGACTGACCTGCAGATGGAAGTCGTGCCACATGCCCGCGAACGGCGAGCTCGATGCTTGTTTTCGAAGNGCGCANGCGGTTTCGATCTTGTCCGCG







TCAACGCAGATCGGATCTCGCCGCGGTCTGCATGACGATGGGCGCAGGCCCGCTCATGTCCCGTAGACGGGGAGATACGGGCAGCCGCGGATCGAGACCTACGTAG







CGCGGCGCCCATCGTGCCATCGACGAAGAATGACGGATCGCGCAGCGCCGTCGCGTCGCTTCGATGTCACGCGAGATCGCCACGGCAGATCAGCGATGCGCGGGC







:::::::::::::Rv61T7.seq:::::::::::::







CGGTACGCCGGCAACAAACGCCTTGTGACGAGCGCGTCCGAGCGGTCATCGGCCTCCACCGTCATGCACAGCTCCTTCTCCAGGTCTACGCCGACGTCGCGGTCCA




(SEQ ID NO. 618)







CATTGGTGAGCTTGGCGAATGCCTCGGCAACCTCGTCGAAATGCGCCTCCGCGTCCGCATCGAAGGTCGCCATGTCAAAGATCAACTCGACGTAGTAGCTAGTTAC







CGCATCAGGTCAGTGTTTGCTGGCCTCGGAGTCCGGCCGAACAATGGCCATTTCCCGCGACTCTAGAATCCAGTCATCGTCTCGGTGACGACGCCTTGCCGATCAC







ATAGCTCGACCGGATCGGAGAGAATCTGGTTCTCGT






Clone Rv62




:::::::::::::Rv62SP6.seq:::::::::::::







ATACTCAAGCTTAAGCGCAGCAGTACCGGCGGTGCCTGGGCATCCCAGCAAAACGGGGAGCTCAACGAACGATTCCTGAACGAAGGGTCGTCCACCAACCTCCAAA




(SEQ ID NO. 619)







CCGAACGGTTGCCAGCCCCGGC







:::::::::::::Rv62T7.seq:::::::::::::







GCAAGTCCGCTCAATGTGGTTGTGATCACANGACTACGTCGCCTCAATCAGCTCAAACGTCACCCCGTGGCGTGCTGCGCAGCATGAAGGTCGGCGCCCGCACGAT




(SEQ ID NO. 620)







GTGGGCGAAGCAACAGGTAATAACTGGTCGGCATGGGTCAACCCTCATTGGGCCGTTGCGGATCGGGTGCACGCCCGGAGTGCCGGTCGAACTCAACACCGCCTTC







ACCGATCTTTTCGTCGAAAATGGCGGTCGTGTCGGGGTATACGTCCGCGATCCCACGAGGCGGAATCCGCTGAGCCGCACTGA






Clone Rv63




:::::::::::::Rv63SP6.seq:::::::::::::







ATACTCAAGCTTCGCGCCCTCAAGCGGCTGAAGGTGGTTCCGGCGTNCCAACNGTCGGGCAACTCGCCGATGGGCATGGTGCTCGACNCCGTCCCGGTGATCCCGC




(SEQ ID NO. 621)







CGGAGCTGCGCCCGATGGTGCAGCTCGACGGCGGCCGGTTCGCCNCGTCCGACTTGAACGACCTGTACCGCAGGGTGATCAACCGCNACNNANNGNTGAAAAGGCT







GATCGATCTGGGTGCGCCGGAAATCATCGTCAACAACNAGAANCGGATGCTGCNGGAATCCGTGGACGCGCTGTTCGACAATGGCCGCCGCGGCCGGCCCGTCACC







GGGCCGGGCAACCGTCCGCTCAAGTCGCTTTCCGATCTGCTCA







:::::::::::::Rv63T7.seq:::::::::::::







TGCGCATGGCAGTTGTTGCCGGCTTGAGTCGCGTTAGCGCGGATTCCACCACATCCCTTGCGAAGTCGTGGGTGCAATGATGTAGCGCTTCTCCCATCGAGATAGT




(SEQ ID NO. 622)







GGAGCAACGCAATCCGTGCGTACGTTGGGTCGTACTCGAGTGCGCANCTTGGCGTTGACACCATCTTTGTCATTGCGGCGAAGTCGATCATCCGGTAAGCGCGCTT







ATCGACGCCGCCTCTGTGCCGGGTGGTAATCCGGCCATGCGCTTGCGTCCACCGCGACGTGCAGCGGGCGCACACCGACTTCTCCGGGTGACGGGTGATCTCGGCG







AATCAGAACCTGGCGCGCGACACAGCGTCGTGGCTGTACTTGC






Clone Rv64




:::::::::::::Rv64SP6.seq:::::::::::::







TGGGTGATCAGATACTGGCTAGTTGGTCGGGTGGGGTGATCGAAGATCGCGGTGGCCGGCAGCGTTACTGCGGTGACGCTGTTAAGCGGTTACGTACTCCACGGCA




(SEQ ID NO. 623)







CTCAANGAATTANATCCCGAATCGGCAAACCCTGGCCAGCGTCGAGTCCGCAGCGCCGTCGCGCCCCCCACCGCTGCGGCATGCTCACATACCACCTCGATCGCTG







CGGGAGTTGCTCGTCGGCCGACCGACCGGCCAGCCGGGCGGCAAACCGGAGGACCCAAGATTCAGCACCACCATCGCTAGCCCGATCTGGCCGCGCGTGG







:::::::::::::Rv64T7.seq:::::::::::::







TCGTAGCGGTTGCGACCANTCCGCGGACAGCTCCGCCACGCGACGGGTCGGGATCACCGCGGTCAAACCACCGAGCGGCGAGGATCTCTGGCCGTCGACGTGACCG




(SEQ ID NO. 624)







CGCACGGCCGCGGTGATGGCCAGTCCCGACCGCCGTTCCACTTGGCGTACGCGCTGGATGTGTTGTGCCGCAACGGAATCCCACCTCAATTATGACCTCGTTGTGG







GCGAGCGCGGTATCGTACGCCCGACCAGGAATCGTCGATGCTATCTCACGTCACCGAAGGCCTCTCCCAGCACACCGCATCCAGAACGTGCACACNGTCGACATGT







CTCGGCGGATCCGCCTGCAGAACGAACGCCANGTGCGCTGTGCGACACGGGTCGCGATCACCGCTCGCACGCGGAGATCGGCACACGCGCAGCGCATCGATCATAA







TCTCTCGATGCGGTCTCCACCACCGAACAG






Clone Rv65




:::::::::::::Rv65SP6.seq:::::::::::::







ATACTCAAGCTTCGCTGAGGTGGTGGGGCACGATCACGTCACCGCACCGCTGTCGGTGGCGCTGGATGCCGGCCGGATCAACCACGCGTACCTGTTCTCTGGGCCG




(SEQ ID NO. 625)







CGTGGCTGCGGAAAGACGTCGTCAGCGCGTATCCTGGCNCGGTCGTTGAACTGTGCGCAGGGCCCTACCGCCAACCCGTGCGGGGTCTGCGAATCCTGCGTTTCGT







TGGCGCCCAACGCCCCCGGCAGCATCGACGTGGTAGAGCTGGATGCCGCCAGCCACGGCGGCGTGGACGACACCCGCGAGCTGCGGGACCGCGCGTTCTATGCGCC







GGTCCACTCACGGTACCGGGTATTTATCGTCGACGAGGCGCACATGGT







:::::::::::::Rv65T7.seq:::::::::::::







GCACTCACGCTGGTACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACTCGTTCGGCGTGCAGGACGCGGCGCAA




(SEQ ID NO. 626)







ACGTACTTCGGCATCAACGCGTCCGACCTGAATTGGCAGCAAGCGGCGCTGCTGGCCGGCATGGTGCAATCGACCAGCACGCTCAACCCGTACACCAACCCCGACG







GCGCGCTGGCCCGGCGGAACGTGGTCCTCGACACCATGATCGAGAACCTTCCCGGGGAGGCGGAGGCGTTGCGTGCCGCCAAGGCCGATCCGCTGGGGGTACTGCC







GCAGCCCAATGAGTTGCCGCGCGGCTGCATCGCGGCCGGCGACCG






Clone Rv66




:::::::::::::Rv66SP6.seq:::::::::::::







ATACTCAAGCTTGTATAAAAAGATCGGTGAGCGCATCGATTCGCTCCGCCGGGTTTGCCGCTGCGGCGGCGGAGCTGCCGTGACCGTCTATTTGGGTGATCAGATA




(SEQ ID NO. 627)







CTGGGCTAGTTCGGTCGGGGTGGGGTGATCGAAGATCGCGGTGGCCGGCAGCGTTACTGCGGTGACGGCTGTTAAGCGGTTACGTACCTCCACGGCACTCAAGGAA







TTAAATCCCGAATCGGCAAACGCCTGGCCAGCGTCGAATCCGGCAGCGCCGTCGCGCCCCAGCACCGCTGCGGCATGCTCACATACCACCTCCATCGCTGCGGCGA







ATTGCTCGTCGGCCGACCGACCGGCCAGCCGGGCGGCAAACCCGGAAGA







:::::::::::::Rv66T7.seq:::::::::::::







CCTCATCATATGCCGATAGAGCTCTACATATTCAGGAGATCACCATGGCTCGTGCGGTCGGGATCGACTCGGGACCACCAACTCCGTCGTCTCGGTTCTGGAANGT




(SEQ ID NO. 628)







GGCGACCNGGTCGTCGTCGCCAACTCCGGAGGGCTCCAGGACCACCCGTCAATTGTCGCGTTCGCCCGCAACGGTGAGGTGCTGGTCNGCCAGCCCGCCAAGAACA







GGCAGTGACCAACGTCGATCGCACCGTGCGCTCGGTCAAGCGACCATGGGCAGCGACTGGTCCATAGAGATTGACGCAAGAAATACACGCCCGGAGATCTCGCCGC







ATTCTGATGAACTGAACGCGACCCGAGGCTACTCGGTGANGACATNACGACGCGTTATCACACCCCGCCTNCTTCAATGACCCCACGTCNGGCACCAAGGACCCGG







CAATCGCGGCTCACTTGNGCGATNGTCNACAACCAACGCGNCGCCTGGCTACGGGCTCAACAAGGCANAAGACACAATCCGCTCTCGATTGGTG






Clone Rv67




:::::::::::::Rv67SP6.seq:::::::::::::







ATACTCAAGCTTATCGAGGCGGCGCATACCGAAGCGTGGGAAATCCAGACCGAATACCGCGACGTGCTGGACACTTTGGCCGGCGAGCTGCTGGAAAAGGAGACCC




(SEQ ID NO. 629)







TGCACCGACCCGAGCTGGAAAGCATCTTCGCTGACGTCGAAAAGCGGCCGCGGCTCACCATGTTCGACAACTTCGGTGGCCGGATCCCGTCGGACAAACCGCCCAT







CAAGACACCCGGCGAGCTCGCGATCGAACGCGGCGAACCTTGGCCCCAGCCGGTCCCCGAGCCGGCGTTCAAGGCGGCGATTGCGCATGCTACCCAAGCCGCTGAG







GCCGCCCGGTCCGACCCGGCCAAACCGGGCACGGCGCCAACGGTTCGCCCGCCGGCACCACCGGTCCGGTGACCGCAGTACGGTCCCCCCAGCCTGACTACCGTGC







CCCGGCGGGCT







:::::::::::::Rv67T7.seq:::::::::::::







TGGCCGGGCTGGTAGCCCGCGTATGGCAAGGTTCCGCTCAATGTGGTTGTGATGCAGCAGGACTACGTTCGCCTCAATCAGCTCAAACGTCACCCCCGTGGCGTGC




(SEQ ID NO. 630)







TGCGCAGCATGAAGGTCGGCGCCCGCACGATGTGGGCGAAGGCAACAGGTAAGAACCTGGTCGGCATGGGTCGAGCCCTCATTGGGCCGTTGCGGATCGGGTTGCA







GCGCGCCGGAGTGCCGGTCGAACTCAACACCGCCTTCACCGATCTTTTCGTCGAAAATGGCGTCGTGTCCGGGGTATACGTCCGCGATTCCCACGAGGCGGAATCC







GCTGAGCCGCAGCTGATCCGGGCTCGCCGCGGCGTGATCCTGGCCTGTGGTGGTTTCGAGCATAACGAGCAGATGCGAAT






Clone Rv68




:::::::::::::Rv68SP6.seq:::::::::::::







GTCCAGTCAAGCATCGGTCCTCTCCGACTACGCCAAGANTGGCGACGTGTCAGTGCANACAGCGGANATGGTGGCGCCTATGCGTCGACGCTCACAAACNGCGGTG




(SEQ ID NO. 631)







ANCGCGTTCTGGTCGTGCACCATCGAGCCGTGCCAGCCCGGCCGCGTGCCGTCAGCCGCATCCACTGGATGCCTTCTCGGNGTTTCAATCANGTACANGCGACGTT







CGCCACCATCGTGCCGGGGCACGGTTAGCGAGAAACCGCCGACTTCACCGATTGCCTCGGTGATGCCGTCGAACAGATCGGGCCTATTGTCGACAGCCAGTGTGAT







NCGTATTTGCCGCCGTGCTCCTCGTCGCAACGATGCGAACACAGATCCGTGGNGGACGATAGCGGCTGACAANGTGGGGGCAACACAATCACATGCCACATTTCTT







CATTTCACGCCCACAACCCAGACTTCGTCTCGATGNGCCG







:::::::::::::Rv68T7.seq:::::::::::::







CACGCGGTCTGGCCCGATCCGAAGATCCCTTTGCCGGCGTGGCGGCTCTGCTCGGCGGTGTTGTACACTTCTCGAACACCTCGGCACCGACACCACCACCGTNGCT




(SEQ ID NO. 632)







TGAACACCGCCAACATCGGCAGCAGATCTTGATGGTCCTGGTGAATCCCACGGTGACTTTGGAGTGGAAGGCGCCATACTGATCGCCGCGCCAGCACATGAGCTAG







CGGCAGGAAAACCAGCAGCCGCTCACCTTGCGCAGCAGCGTCNGGTGATATGCCTGGCGCCCTTAATCTCGTGAACCAGTTGGATTGGGTCAACTGGCAGCCTTGG







GTCTCCGGTGGTGCCGANGTGTANATAAGCTCCCGGGTCCGTCAACGTANTGCGCAGGCGGCGGTTACTCGGCGGGTCAACGAGCCCCGCTCGTGAGCNATCAGCC







TTTGGACCGAACGGGATTCATACTCCGCAGGCGGCCCTCCGAAATCGGCACATGTCCTTTGATCGTTCGCAACAN






Clone Rv69




:::::::::::::Rv69T7D3.seq:::::::::::::







GGCCATGTCACATCGGTGGTACAGGTAAACCGCGCCGTGTGCGCGGTCTCGGAGATCAGAACGTGGTCGCAGTTGAACCGCGGGCTTTCAGCCAGTCGCGATAATC




(SEQ ID NO. 633)







GGCGGAAGTCGGCGCCTGCCGCCCCAACTAGCGCGACTCGCCACCTAGCACACCGATGGCGAAGGCCATGTNTCCGGCCACGCCGCCGCGGTGCATCACCAAGTCA







TCGACTAGGAAGCTAAGCGACANCTTGTGCAGGTGTTCGGGCAGTAGCTGCTCGGAAAATCGGCTGGAAACCGCATCAAATGGTCGGTCCAATCGAACCGGTTACC







CGATCGTCACAAAAATCTCGTCCT






Clone Rv6




:::::::::::::Rv6SP6.seq:::::::::::::







GGGTCTACAACCACCGGGTCTGACTTCTGGGCTTCCACCGCTCGCGCCGTCGCGACAAACAGCGCGGTCGAACCGACACTCGTTGTGATGTCCCAGCTATCACCTC




(SEQ ID NO. 634)







CGGTAGGCACCCAATCGACCCTACCCGGCTATCTCACCCCCGATCTCCAGGCTCCGCCGATCCATGCGCATCCCGGTCCGGATCCC







:::::::::::::Rv6T7.seq:::::::::::::







CAGGCATGCAAGCTTGTCGTATTCCGTGGCACTGTCAGACATATGCGCCGCTCCTCCTCATCGCTGCGCTCGGCATCGTCGCCGGCGGTCATGGCGTCACCCTACC




(SEQ ID NO. 635)







CAAGCCGAACGCGAAACGAGAACGTGTTCCATTATTAGGGTGTGAGCACCAATACCAGATTGCTCACCAGGAACTCACGCAGCACCGGGACGGATGTCAGCCACCA







CGCCCATCTGGGGTGGTAGCGGGGAAATACGGCTAACGCGGCTCCGGTGCCGGCAGCCCAGCGCAGACCCTCGGCGGCGGACACGGCTAACAACGACGACCCATAG







TTGTTCTTTGCCGGATGGCCGTGTTTGCTGACATATCGGGCGCGGCGCCGGCGCCGCC






Clone Rv70




:::::::::::::Rv70SP6D2.seq:::::::::::::







NCTACGCTGCTGAATGTTGTGCGCCGGAGGANCTCAAGACCCACGCGGTTGTACGCGGACNTGCGACATGTTCAACCGCCGGA




(SEQ ID NO. 636)







:::::::::::::Rv70T7D3.seq:::::::::::::







CTAACCAACAAGCCATGGTGGTTGGCGCCGTCGAGAGGTCGGCGGTCGCCACAACGGGAAGATCGCCTTGAGCGTCGCTCGACCGCCGCCTCGAGTTGGGTCATAA




(SEQ ID NO. 637)







CGAAGTACTGATGCCGATCATGTCGACGTGTCCGTCGCATCAGCGTGCAGCGGCGACCCCTCGACGAGCCTCGGTGCCGCCGCGGCCAGGGCACCAGCTGTTTTAG







CGCATTGTGCTCCGCCGGTAATAAAGGANGTCGGTCGCCTCCGCTGCTGTGGTTGCGGAATAACATCTTCCCTTCCTGCAACAGGATGAGAATGGTTTTAATTGCT







C






Clone Rv71




:::::::::::::Rv71SP6.seq:::::::::::::







CTAAGCTTTCGGGTCCGCCGCCACTAGTACCGCGTTGCCGGCCCCGCCGACCTAGAATCTTCCGCCCATTGCCGTTTCCTCCCGCCGCCGGGTT




(SEQ ID NO. 638)







:::::::::::::Rv71T7.seq:::::::::::::







TCTGGTGCCGGGTGTGCCGACGGGTCCGTCCGCCTCTGCTTCAGTGATTCTGTGATGCGACCGGCAACGTCCTCGTTGTTCGGTGTCTATGTGGTCCGTCTCTCCT




(SEQ ID NO. 639)







TGTTCCGCATACGATT






Clone Rv72




:::::::::::::Rv72SP6D2.seq:::::::::::::







GCGATCGNTNACCACAAGGGCGCAACCGTTCGCGCGTCGACTGAACGTGCTGCCGCCTGGAGAACTGGCGCTGCTGCCACCTGGTCGGCGCATCGGCACTTCGAGG




(SEQ ID NO. 640)







ACTGGATTTCGACGCGTGGCCCGACCTGANGTNGGCGGTGGACNNGTGTGCACCCGGTTGATTCCTCGGCCTTGCCGGGATGCCACCTGCGCCTGGTGGTCGAT







:::::::::::::Rv72T7D3.seq:::::::::::::







CGTGACCGGACGGGGTGCCGCGCGAACCGGTCTTGGCCAATTGCCGGGGACTGGGGCTGGAGTATAAAGCGGGCCTGTTGCCGGAAGATAAAGTCAAAGCGGTGAC




(SEQ ID NO. 641)







CGAGCTGAATCAACATGCGCCGCTGGCGATGGTCGGTGACGGTATTAACGACCGCCAGCGATGAAAGCTGCCGCCATCGGGATTGCAATGGGTAGCGGCACAGACT







GGCGCTGGAAACCGCCGACGCACATTAACCATAACCACCTGCGCGGCTGGTGCAAATGATTGAACTGGCACGNCCACTCACGCCAATATCCGCCAGAACATCACTA







TTGCGCTGGG






Clone Rv73




:::::::::::::Rv73SP6.seq:::::::::::::







ATACTCAAGCTTCTTACCCANAGCATGAACCCCGCCGTCCAATGCCGCCACCGTGGTGCTGTCGGCCGGCCGGGTGCGGGCACAATCGCCGAGTTCGGCGAACAGA




(SEQ ID NO. 642)







TCCTCGAAGGTCTTCACGGCCAGCGATTGTTGCACGTGTCAGCCAGCCAAGTCACGGTGGTTTGACGCCACACGTTCGCCACCGCCGCGCCGCGCATTAGGGCATC







CTAATATAGGTTAGGCTACCCTANTTATTCCTGTGGTCNAAGGAGGCAGCCGAACGTGACCTTCCCGATGTGGTTCGCAGTTCCGCCGGAAGTGCCGTCAGCATGG







CTGTCCACCGGCATGGGCCCCGGTCCGCTGCTGGCCGCGGCCAGGGCGTGGCACGCGCTGGCCGCGCAATACACCGAAATTGCAACGGAACTCGCAAGCGTGCTCG







CTGCGGTGCAGGCAACTCGTGGCAGGGGCCCAGCGCCGACGGTTCGTCNTCCCCATCAACCGTTCCGTATTGGCTAACCACCTGCACGGTGGCACCGCACAACGCC







GCCACAAACGCGCCCCGGTATAC







:::::::::::::Rv73T7.seq:::::::::::::







GGCCGAACTTAATCGGTTGTTGGCGGCTGCCGAGTTGGGTCACTCGGGGGGTGTGCACTGGCACATGGTGGGCCGGATTCAACGCAACAAAGCCGGGTCGCTGGCT




(SEQ ID NO. 643)







CGCTGGGCGCACACCGCTCACTCGGTGGACAGCTCGCGGTTGGTGACCGCGCTGGATCGGGCGGTTGTTGCGGCGCTGGCCGAACACCGTCGTGGCGAGCGGCTGC







GGGTTTACGTCCAGGTCAGCCTCGACGGTGACGGATCCCGGGGCGGCGTCGACAGCACGACGCCCGGCGCCGTAGACCGGATTTGCGCGCAGGTGCAGGAGTCAGA







GGGCCTCGAACTGGTCGGGTTGATGGGCATTCCGCCGCTGGATTGGGACCCGACGAAGCCTTTGACCGGCTGCAATCGGAGCACAACCGGGTGCGTGCGATGTTCC







CGCACGCGATCGGTCTGTCGCGGGCATGTCCAACAACTTGAAATCCCGTCAACATGGTCGAC






Clone Rv74




:::::::::::::Rv74SP6.seq:::::::::::::







GCTTCCCCTGATACTCGACCAGCCCCACTCGGGCCAATACGTGAATGTCCTAGCATTTTTCACCCGTTCACGGGCTAGTCGAGTAGTAGACGATTGATTAGCCTGA




(SEQ ID NO. 644)







ACGTACCTCCGACGGCCAGCTGACGAACGGGTTTGACGGA







:::::::::::::Rv74T7D3.seq:::::::::::::







TCAGCTGTCTGTAGAAGGGCTGGCGATACTGTGCACTGTCTGATATCGCNNCGTNGTGGGACTATNCAGNCCATNANGATGCGGTTCNGNNNNTGCAGAGNATCCT




(SEQ ID NO. 645)







GGNACACATNCGGTTCACGTTAATCANCATCGCGANTTNCTNCGTNTTCGATTANTTCTGCTAACGNNTCTNNNAGTGCCTGCGGGTCGACTCTAGAG






Clone Rv75




:::::::::::::Rv75SP6D2.seq:::::::::::::







NCTCTGCCGGGCNAGAGCGCAGAGTCGGACGGCTTCGTCGATCGTGAAGCGACCNTGCGATGANCAGATATCGNTNACACTGCTCANAAACTTCGGATCATCGNTG




(SEQ ID NO. 646)







ATACACAGGCCAACGGGTAGCGGTTGTCCAACCGCTTCGTCAACGANATGGGATCGTGACGANCCTACGCTCGCAGGATATGTCGCNGACCNGNTCTAGANAN







:::::::::::::Rv75T7D3.seq:::::::::::::







CACTTCATGCTCGTGCGTTGGCNTCGATTTGCNCGAGNGGTTAGCTCCTCGAGTGNGTGACGTATCACTCCGGCNGACTANCCGTATCNGCGTCCCGCACCGGTCA




(SEQ ID NO. 647)







ACTGGTCTAGCCACACCGGGGAGAATNCNGCAGGCCNGCTATCGACCNATCACGGCTTGTCGNNAAGATAGNCAGCC






Clone Rv76




:::::::::::::Rv76SP6.seq:::::::::::::







ATACTCAAGCTTGCCAACCGCCACCCTGCATCCGGGGGGCGAGCACTGCTCCGCCGACCAGTACGAACCAACCTGCGGTGCCCAGGCCATTGACAATGTGCTGGTC




(SEQ ID NO. 648)







GGCGCCCGCGAGTTCTAGCACAGCAACGCCGCGGCCACCACAGGGGCG







:::::::::::::Rv76T7.seq:::::::::::::







CGGTCGGTGTGCTTGGCGGCGTCGGTATCAACACCGCCCACGAAATGGGGCACAAGAAGGATTCGCTGGAGCGGTGGCTGTCCAAGATCACCCTCGCCCAGACCTG




(SEQ ID NO. 649)







CTACGGGCACTTCTACATCGAGCACAACCGTGGCCATCACGTCCGGGTGTCCACACCGGAAGACCCGGCGTCGGCGCGGTTCGGCAAAACTTTGTGGGATTTCCCG







CCCCCCC






Clone Rv77




:::::::::::::Rv77SP6.seq:::::::::::::







AATACTCAAGCTTCGCGGAGGTGGTGGGGCAGGAGCACGTCACCGCGCCGCTGTCGGTGGCGCTGGATGCCGGCCGGATCAACCACGCGTACCTGTTCTCTGGGCC




(SEQ ID NO. 650)







GCGTGGCTGCGGAAAGACGTCGTCAGCGCGTATCCTGGCGCGGTCGTTGAACTGTGCGCAGGGCCCTACCGCCAACCCGTGCGGGGTCTGCGAATCCTGCGTTTCG







TTGGCGCCCAACGCCCCCGGCAGCATCGACGTGGTAGAGCTGGATGCCGCCAGCCACGGCGGCGTGGAGCAACCCCGCGAGCTGCGGGACCGCCC







:::::::::::::Rv77T7.seq:::::::::::::







GATGGCACTCACGCTGGACAAGACCTTCACAAAATCTGAAATCCTGACCCGATACTTGAACCTGGTCTCGTTCGGCAATAACTCGTTCGGCGTGCAGGACGCGGCG




(SEQ ID NO. 651)







CAAACGTACTTCGGCATCAACGCGTCCGACCTGAAATTGGCAGCAAACCGGCGCTGCTGGGCCGGGCATGGTGCAATCCGAACAAGCACGCTCAACCCGTACACCA







ACCCCGAAGGGCCGCTGGCCCGGCGGAACCTTGTCCTCCA






Clone Rv78




:::::::::::::Rv78SP6.seq:::::::::::::







AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTCTGGGCGTCGTGGTGCCCGGCCTGCCGGTGCAGGAACTGGATTTTA




(SEQ ID NO. 652)







CTGCCATCTCTCGCGACCCTGAGGTGGTCCAGGCTTACAACACCGACCCACTCGTGCACCACGGACGGGTTCCGGCCGGGATTGGCCGCGCGCTGCTGCANGTGGG







CGAGACCATGCCGCGGCGANCACCGGCATTGACCGCGCCGCTGCTAGTGCTGCACGGCACCGATGACCGGCTGATCCCCATCGAAGGCAGCCGTCGCCTGGTCNAA







TGTNTNGGATCNGCCGACGTGCANCTGAANGANTATCCCCGGCTGTNCCACNAGGTGTTCAACGAACCGGANCGCAACCAAGTG







:::::::::::::Rv78T7.seq:::::::::::::







CAAGGCATACGCCAAGACCCAAGGGATCGCAGTCACCTCCGTCAACGGCCTGGTCGCCGGCCACGGGTCCGTGCAGGAGACGTGGCTGGCCATGCAAAGCGCCGCC




(SEQ ID NO. 653)







GCCTTATCAGGAACGCCCCGGCTTGTCGGCTTTTCCTGCATCGACACATTTCCGGAGGTGTTGTGGTTGGCGCANCGCGCGAGACAGGCCTGGGATGGCGTGCGCA







TCGTCATCGGGAATGCGATGGCAACACTGAACTACGAGCGCATCCTGCGCCAGCATGACTGTTTCGACTACGTCGTCGTTGGCGACGGGGANGTAGCGTTCACCAA







GCTGGCCTTGGCCCTGGCGAATGACCTGCGGTTGACGACTCCCGGGACTAACCCGCCGTANTGAGCAAGGACAGATTCTGCGCACACCCTCCTCGCTGGTCGACCT







TGACA






Clone Rv79




:::::::::::::Rv79SP6.seq:::::::::::::







AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTGCCGGTGATCTGGGTGGCCAACTCGGCGGGCACCATCTCCATCACG




(SEQ ID NO. 654)







ACNGCAAACGCTCCGGCTTCGGCGACAGCGATCGCGTCTGCGATNGTTTGTTCGGCGGCGTCTCCGCGGCCCTGCACCCGGAAGCCGCCCAAGGTGTTGACNCTTT







GCGGGGTGAAGCCGATGTGTGCCATCACCGGGATNCCCGCCGCGGTCAGACANGCGATTTGCTCGGCCACCCGCTCACCGCCCTCGANCTTGACNGCATGTGCGCC







GCCGTCCTTGAAGAAACCGGTGGCGGNGGCAACCC







:::::::::::::Rv79T7.seq:::::::::::::







CGTTGAGATCCAGCTGCGCACTGTGCAGCGCCTCGGTGGTCTGCTCGGCCTGCCGGGATAACTCGTTGAGCTTGGCCAGCGCGTCGTCGGCCGGATCAGCCAGCAC




(SEQ ID NO. 655)







ATTCGCGGCCAGGACGCCGGAGGAGACGGTGAAGCTCGCAAAGAAACCTATGGCGGACCGCATGATTACACGCGCGATCAACCACCTCTGGTCGAGCCTCAAAATT







TGCTTCCTTAAACGGGCCATCGACGGATGACGTCGAGCTGGTTTAGGTCTCAAACAGGTTACGAAACGATCTCGGAATTGTCCAAAAGGGGAAGTTAAGAAAATGG







ATAGATTTCTACCATTTCGCTGTGGACGATCGTACTTCTGCTATAGGGCTCCAGGGGCATCGACACGCAACGACCTTACGCGACACCGGATCCGCGCTGGCGGCGG







AACGGCACCANGCGCAACCGAAGGGCCAATCCGACATCGG






Clone Rv7




:::::::::::::Rv7SP6.seq:::::::::::::







ATACTCAAGCTTATCTAGGCGCCAGCTTGATTGGTCTGGTTGCATTGGCCAGCTGCGCGAGCCTGGCTCACTTCAACTACAACAACCGCAAACAATTGCCGCCTTC




(SEQ ID NO. 656)







GGATCCGAGTTCGGTTGGGTACGCGGCAATGGANCACCATTTCTCGGTGAATCAGACTATTCCTGAGTACTTGATCATCCACTCTGCACACGACCTGCGAACCCCG







CGCGGCCTTGCCGACCTGGAGCAGCTGGCGCAACGTGTGAGCCANATCCCAGGCGTTGCCATGGTTCGCGGTGTGACCCGGCCAAACGGGGAAACCCTTGAACAGG







CCCGGGCGACATACCAAGCCGGCCAAGTTGGCAACCGGCTGGGCGGCGCGTCGCGAATGATCGATGAGCGCACCGGCGACCTGAATCGGCTGGCATCGGGTGCCAA







CCTGTTGGCCGACAATCTCGGTGACTTCGCGGTCAAGTCAGCCGGGCCGTTGCGGGTGTCCGCAGCCTTGTCCAGCCCCTCGCTTACTCCA







:::::::::::::Rv7T7.seq:::::::::::::







CAGGCATGCAAGCTTTTTGAGCGTCGCGCGGGGCAGCTTCGCCGGCAATTCTACTAGCGAGAAGTCTGGCCCGATACGGATCTGACCGAAGTCGCTGCGGTGCAGC




(SEQ ID NO. 657)







CCACCCTCATTGGCGATGGCGCCGACGATGGCGCCTGGACCGATCTTGTGCCGCTTGCCGACGGCGACGCGGTAGGTGGTCAAGTCCGGTCTACGCTTGGGCCTTT







GCGGACGGTCCCGACGCTGGTCGCGGTTGCGCCGCGAAAGCGGCGGGTCGGGTGCCATCAGGAATGCCTCACCGCCGCGGCACTGCACGGCCAGTGCCCGCGGCGA







TTCAGCCATCGGGACATCATGCTCGCTTCATACTCCTCGACCAGTCGGCGGAACAGCTCGATTCCCGGAACGCCCACGCATGGTG






Clone Rv80




:::::::::::::Rv80SP6.seq:::::::::::::







AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTGTAGAAAAAGATCGGTGAGCGCATCGATTCGCTCCGCCGGGTTTGC




(SEQ ID NO. 658)







CGCTGCGGCGGCGGAGCTGCCGTGACCGTCTATTTGGGTGATCAGATACTGGGCTAGTTCGGTCGGGGTGGGGTGATCGAAGATCGCGGTGGCCGGCAGCGTTACT







GCGGTGACAGCTGTTAAGCGGTTACGTATCTCCACGGCACTCAAGGAATTAAATCCCGAATCGGCAAACGCCTGGCCAGCGTCNAGTCCGGCAGCGCCGTCNCGCC







CCAGCACCGCTGCGGCATGCTCACATACCACCTCGATCGCTGCGGCGANTTGCTCGTCNGCCGACCGACCGGCCANCCGGGCGGCAAACCCNGAAGACCCAAGAAT







TCATCACCACCATCGCTAGC







:::::::::::::Rv80T7.seq:::::::::::::







CCTTCTTGACACCCACCTCGCCATCGACCTTGAGCACTCCGTCGTAGTTGGTGAACATGTGACCGGCGATCGGGCGGGTGAACGCGTACTGGGTGTCGGTGTCGAC




(SEQ ID NO. 659)







GTTCATCTTCACCACGCCGTAGCGCAGCGCCTCCTCGATCTCCGACTTAAGCGAACCCGAGCCGCCGTGGAACACGAAATCNAACGGCTTGGCGTCNGCCGGCAGT







CCGAGCTTGGCCGCCGCCACCTGTTGCCCTTGCGCAAGGATGTCNGGGCGAANCTTGACGTTGCCGGGCTTGTANACGCCATGCACGTTGCCGAACGTCNCGGCCA







GCANGTATTTGCCGTGCTCACCGGCGCCCANCGCCTCGATGGTTTTCTCGAAGTCCTCCGGGCTGGTGTACAGCTTCTCGTTGATCTCGTTCGCCACGCCGTCCTC







TTCGCCGCCGACG






Clone Rv81




:::::::::::::Rv81SP6.seq:::::::::::::







AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTGGAAAGGAGATCCCCGGGAACCTGGTGGCAACCCCGCCATTGGGGT




(SEQ ID NO. 660)







TGTTGGGATTGCCGATCAGCGTGAANGAAAGCTCGTCTGGAGACAGCGGGTCGGCCGAAGCCGCAAGATTGGCCATCACTAGTGACGANATCGTGGCGCTCTGCGA







GTANCCNAAGACAGTGACGTTGTTNCCGGCGGCAATTTGCTGCCGAATCGCACTTTCGAGAATGACNGCACCCTGCGCCACCGANGAATCNAAAGTGAGGTTCTTG







ATCACGACCACCGGGTNGAGCCCTTGGGGCGTGAAGANCGCCTGCGCNATAACACCCGGGACGCTGCCACTCATGTNCAGCGCGTTCGCGANCTCNACATATCT







:::::::::::::Rv81T7.seq:::::::::::::







TCCTGGTGATCGANGGCCGCGGTTCCGGCCGAAAATCCGGTTCGGGTTCGGGTCGCGGTTCCAACTTGANCGCGGTCCGCAGCTGATTCACCGTGGCAACGCCGGC




(SEQ ID NO. 661)







CAACTGCGCATAATGCGCATCCGAACCCTCACCCGCCCGCCCCGCGATCACCCCAACCTGATCCAACGACAACCGCCCCTCCCGCATACCCCGGGCGCAGCGCGGA







AACTCCGGCAACCGCCGCGCCACCGTGGCGATCGTGTGGGCGTTGCCTGACGAACANCCCATCTTCCAGGCCACCAACCCCGCCACCGACCGCGCCCCCGTCACAC







CCCACAACCCGTCGCGATCCAGCTCAGCCACGATCTCCACAATGCGCCCATCAATCGCATTGCGCTGAACGGGCAACTCCGCCAACTCCTCCAA






Clone Rv82




:::::::::::::Rv82SP6.seq:::::::::::::







AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGATCTGGTACCCATCCGTGATACATTGAGGCTGTTCCCTGGGGGTCGTTA




(SEQ ID NO. 662)







CCTTCCACGAGCAAAACACGTAGCCCCTTCAGAGCCAGATCCTGAGCAAGATGAACAGAAACTGAGGTTTTGTAAACGCCACCTTTATGGGCAGCAACCCCGATCA







CCGGTGGAAATACGTCTTCAGCACGTCGCAATCGCGTACCAAACACATCACGCATATGATTAATTTGTTCAATTGTATAACCAACACGTTGCTCAACCCGTCCTCG







AATTTCCATATCCGGGTGCGGTAGTCGCCCTGCTTTCTCGGCATCTCTGATAGCCTGAGAAGAAACCCCAACTAAATCCGCTGCTTCACCTATTCTCCAGCGCCGG







GTTATTTTCCTCGCTTCCGGGCTGTCATCATTAAACTGTGCAA






Clone Rv83




:::::::::::::Rv83SP6.seq:::::::::::::







AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATAGAATACTCAAGCTTANCGCCACCTCCCGGGCGGAACTCCACGGCGTGGATNAAGGTACCG




(SEQ ID NO. 663)







GCCGGGATGTTGCGCAATGGCAGGTTGTTGCCCGGCTTGANGTCCGCGTTAGCGCCGGATTCCACCACATCCCCTTGCGAAANTCCGTTGGGTNCNATGATGTNNC







GCTTCTCCCCNTCNANATAATGGANCAACGCNATCCGTGCGGTACGGTTCGGGTCNTACTCCATGTNCGCGACCTTGGCGTTGANACCATCTTTGTCATTGCGGCG







AAAGTCNATCATCCGGTNAGCNCGCNTATGANCGCCGCCTTTGTGCCGGGTGGTAATCCGGCCATGCGCNTTGCGTCCACCGCGAACGTGCAACGGGGGCNCCAAC







GANTTCTCCNGGGTTGAACCGGTNATCT







:::::::::::::Rv83T7.seq:::::::::::::







TGTGTGTGGTGGTAACCCATCTGAGCAGTGTGCCAAACCGGGGCAGCCAGCTCCCAATTGACGTGAGCCCGCTCACTTGCTGGGTAAGCGTCG




(SEQ ID NO. 664)






Clone Rv84




:::::::::::::Rv84SP6.seq:::::::::::::







AACAGCTATGACCATGATTACGCCAAGCTATTTAGGTGACACTATANAATACTCAAGCTTGCGGGTNATNGCCTTGGTCAACGGCACCGTGATCGGATCNGGGTCT




(SEQ ID NO. 665)







ACCGCACACATNGACTGGAGCTTCGGCGAANTCATCGCCTATGCCTCGCGGGGGGTGACGCTGANCCCNGGTGACNTGTTCNGCTCNGGCACGGTGCCCACCTGCA







CGCTCNTCNAACACCTCANGCCACCGGAATCATTCCNGGCTGGCTGCACGANAGCGANNTTGTCNCCCTCCAAAGTCTAAAGGCTGGGCGANANAAGCANAACGTC







CCGACNAACGGCACTCCTTTTCCNTTTGCTCTTC







:::::::::::::Rv84T7.seq:::::::::::::







GAAATCATTGATGGTTTGAGTCACCAGGCCGATCAAGCCTTCGCCGAGCCAAATTCCAATCAAGAGGCCCAAGCCCGTACCAATCAGCCCGGCAACGAGGGATTCC




(SEQ ID NO. 666)







GTCATTATCAGCCAAAATAACTGCTCTCGGGTTACACCCAAACAGCGCAATATGGCGAAAAACGGTCGCCGTTGCACGACATTAAATGTCACGGTATTGTAGATTA







AAAAGATACCCACCAACAANGCAATCAAACTGAGAGCGGTTAAATTGACCGTAAAAGCGTCCGTCATCTGTTTGACNGTGTCCCGTTGGGTATCCGACGTTTCCAT







ACGCACACCGGCCGGCAGTCTTTGTTGGATGCGTNTTGCAATGGCCTCATCTTTGATGATCAAATCGATGTNGCTCAGTCTTCCGGGCATATGGAACAACTCTTGG







GCCGTGGAAATATCAGCAATGATA






Clone Rv85




:::::::::::::Rv85SP6.seq:::::::::::::







CTTTCGCCCAGGCCGGCGCGGATGTCCTCATCGCTTCACGAACATCATCCGAGCTTGACGCTGTCGCCGAACAGATCCGCGCTGCCGGCCGCCGCGCCCACACCGT




(SEQ ID NO. 667)







TGCCGCCGATCTGGCCCATCCCGAGGTGACCGCGCAGCTGGCTGGTCAGGCCGTCGGAGCTTTCGGGAAGCTCGACATCGTCGTCAACAACGTTGGCGGCACCATG







CCCAACACGCTGCTAAGCACCTCGACCAANGACCTCGCGGACGCCTTCGCCTTCAACGTGGGCACCGCCCACGCGCTGACCGTCGCGGCGGTGCCGTTGATGCTGG







AACACTCCGGCGGCGGCAGCGTGATCAACATCAGCTCCACCATGGGCCGGCTGGCGGCGCGGGGTTTC







:::::::::::::Rv85T7.seq:::::::::::::







TGTGGGCTCCGATCCGGCGCGCATGGCATCGACGGCGACGCCGATCGATGACGGCCAGGCTTACGAGCTTGAGGGTGTGAAGTTGTGGACCACCAACGGTGTGGTA




(SEQ ID NO. 668)







GCGGACCTGCTAGTGGTTATGGCGCGGGTACCGCGCAGTGAAGGGCNCCGAGGGGGAATCANCGCCTTTGTCGTCGAGGCTGATTCGCCCGGGATCACCGTGGAGC







GGCGCAACAAGTTCATGGGACTGCGTGGCATCGAAAACGGCGTGACCCGGCTTCNTCGCGTCAGGGTGCCCAAAGACAACTTGATCGCANGGAAGCGACGGTCTGA







AGATCGCGCTGACCACACTCAACGCCGGACGGCTGTCCCTACCGGCGATCCAACCGGAGT






Clone Rv86




:::::::::::::Rv86SP6.seq:::::::::::::







GAGCTGGCCGAGCTGGACCGGTTCACCGCGGAACTACCGTTCTCGCTCGACGACTTTCAGCAGCGGGCTTGCAGCGCGCTGGAACGCGGCCACGGTGTGCTGGTGT




(SEQ ID NO. 669)







GCGCGCCGACCGGCGCTGGCAAGACAGTGGTCGGCGAGTTCGCCGTGCACCTGGCGCTGGCGGCCGGCAGTAAATGTTTCTACACCACGCCGCTGAAAGCCCTGAG







CAACCAAAAGCACACCGATCTCACAGCACGCTACGGCCGTGACCAGATCTGGCTGCTGACCGGTGACCTGTCNGTCAACGGCAACCGCCGGTGGTGGTGATGACCA







CCGAAATGCTGCGCAACATGCTCTAC







:::::::::::::Rv86T7.seq:::::::::::::







GATCTCTGGATCGGCGGGGCTCTCCGGGCCGGCCTCGGCGACCTCAGCGGGCCGCGCCTTCCGGCCGAACCATTCCCTAGCCATAGATGACCGCACCTCGATGCAC




(SEQ ID NO. 670)







GGTTTGGCGGCAACGCGGCAAGGCGTCNGTCGGGCCCAGCCGCGGCAATGCGGGTACCCGGGAGCGCGGGTCNGTANACCANCGCTGGACTGCGTCGCGCGGTGCG







TCNACNTCAAAGTCCCCGGCGTCCCATATCGCGTATGACGCGGGCGCGCCCGGCACCANGGGTGCCGATCCGGCCGTCTCGAACACCACCGGCCCGCCAGCCGCCG







CGGGTCCGGCAGCNAACCCGCCCGCGCCGATACCCGCTGCCCGCGTGCGTGATTGACCGCCGCGCGCACGCTGGCCANGGATCAAAGCCCGTG






Clone Rv87




:::::::::::::Rv87SP6.seq:::::::::::::







GGACGCGTAGCCCGCCAGGCCGGTCAGGGTGCCCTTCCAGTCCACGCCGCTGTGGTCGGCGAACCGCTTATCTTCAATCGAGACGATCGCCAGCTTCATCGTGTTG




(SEQ ID NO. 671)







GCGATCTTGTCCGAGGGCACCTCGAACCGGCGCTGCGAGTNCAGCCACGCGATCGTGTTGCCCTTCGCGTCGACCATCGTCGATACCGCAGGCACTTGCCCCTCGA







GCAGCTGGGCCGAGCCGTTGGCAACGACCTCAGANGCACGATTGGACATCAGCCCTAGCCCGCCTGCGAACGGGAACGTCAGCGCAGTGGCGACGACACTGGCCAA







CAGACAGCACCCAGCCAGCTTCAGAACGGTGATCGCGGCCGGGAAGCGCTCGGGCATGCGTNCTACAGTAGCGACCTCCTGTCACTCCACGTGCCGCTCGGTCCAA







TAGAATCTTTCCGCGGGCGGGTGAATCTCTGCNGGATCGGGGCNGGCGC







:::::::::::::Rv87T7.seq:::::::::::::







GCTCGTTGCCGGCGGCGATCTCGTCGAGCTCGTCTTCCATCGCCGCGGTGAAGTCGTAGTCGACGAGCCGACCGAAATGCTGCTCGAGCAGACCGGTTACCGCGAA




(SEQ ID NO. 672)







CGCCACCCATGACGGCACCAGTGCACTGCCCTTCTTGTGCACGTNGCCGCGATCCTGGATGGTCTTGATGATCGACGANTAGGTCGACGGGCGGCCGATGCCCAGC







TCCTCGAGCGCTTTGACCAGCGACGCCTCNGTGTNNCGGGCCGGCGGGTTGGTGGCATGGCCGTCTGGGGTCAACTCGACNATGTCCAACCGTTGACCCGGGGTCA







GATGGGGCAGTCGCCGCTCGGCATCGTCAGCCTCGCCGC






Clone Rv88




:::::::::::::Rv88SP6.seq:::::::::::::







GTCTTTCGATGGCTGCTTCTTCGGCGCTGACGCTGGCGATCTATCACCCCCAGCAGTTCGTCTACGCGGGAGCGATGTCGGGCCTGTTGGACCCCTCCCAGGCGAT




(SEQ ID NO. 673)







GGGTCCCACCCTGATCGGCCTGGCGATGGGTGACGCTGGCGGCTACAAGGCCTCCGACATGTGGGGCCCGAAGGAGGACCCGGCGTGGCAGCGCAACGACCCGCTG







TTGAACGTCNGGAANCTGATCGCCAACNACACCCNCGTCTGGGTGTACTGCGGCAACNGCAAGCCGTCGGATCTGGGTGGCAACAACCTGCCGGCCAAGTTCCTCG







AGGGCTTCGTGCGGACCATCAACATCAAGTTCCAAGACGCCTACAACGCCNGTGGCGGCCACAACCGCGTGTTCGACTTCCCGG







:::::::::::::Rv88T7.seq:::::::::::::







GCCAGGTCGAGGTCCCATGCGCGTGGGCCATTGATGCTGATCGCCAGGACGTCAAANATTTGGTCCGGCGTCAGCTGGGCGAAAAACGTGGGCCCCAGGACTTGCC




(SEQ ID NO. 674)







CGGAGCTGCCCGGGTTCCCGTCGCGCAGCTCGGCGGCCCCGGTCAGAAANAAATTGCGCCAGGTCGCACACTCCGCGCCGTANGCCAGCTGCTCCAGGGTGTCGGC







ATAGAGCCCGCGGGCCGCAGCGTGCTCGCTGTCGGCGAACACCGCATGGTCGAGAAGCGTTGCCGCCCAACGGAAATCACCTGCGTCNAANGCTTCGCGGGCCAAC







TCCAGCACTCGGTCGATG






Clone Rv89




:::::::::::::Rv89SP6.seq:::::::::::::







NAAACGTTCCGGCTTNGGTGCCGGGCGCTTATTTGCGTCTCTGGGATCACNCTCAGTCGCCGGCGGCTGCCGTTGGGCTATNANTTGCACCGANCCGGAAAATCCG




(SEQ ID NO. 675)







CACNANAACTGCNAGTAGCGGCCTGCAGAANTGCATCCTCGGCGAANCNGACTACCGGTGGACANCNACAAGCGCCGCCGAACAACGCACTGGCCCGAGGGATNGG







CGTCTATCGGCCCCGCCCGTCGAACTNGGAACAGACNGTGCGGTTCTACCGTGATCTGGTGGGAATGCTCNACCANACCTTCCCNANNGCTACGGAACNACGGCGC







GATATTCNGCCNTCCCANCTCGAGCCTGACNCTNGATATCGTCGANNCTCACCATCNCGATCNGCTGTGCCGGTNTTGCTCGGACTN







:::::::::::::Rv89T7.seq:::::::::::::







CGAACGACGAACNCCNCAAGCCATGGTGGTTGGCGCCGTCAAAAGGTCCGCGGTCGCCACTACTGGAAAATCGCCTTGAGCGTCNCTCGACCNCCGCCTCGAGTTG




(SEQ ID NO. 676)







GGTCNTAACGAAATACCTGATGCCGATCANGTCNACGTCTCCGTCGCNNCAACGTGCAGCGGCGACCCACTCTACNANGTCTCGGTNCCGCCNCGGCCAGNGCACC







ACCAGTGACNAATCCNTGCGCCNTCGGGCCNAGCANTCCCGGTGCNACCGNGGTGGGTCCGGCGATGGTNGGGTGTNCTCNNTACNGGAACGCCAGCGCNATCANC







ATCGGCANACTCNCGTCGATGTGCCGCGGCGCAACCATCCCCCACAATGATCNGGTGCGTCTGATCAGGCN






Clone Rv8




:::::::::::::Rv8SP6D.seq:::::::::::::







TTAGGCGTGACGGCCACCGGGGCCACTCCGCACAATCTGTACCCGACCAAGATCTACACCATCGAATACGACGGCGTCGCCGACTTTCCGCGGTACCCGCTCAACT




(SEQ ID NO. 677)







TTGTGTCGACCCTCAACGCCATTGCCGGC







:::::::::::::Rv8T7D4.seq:::::::::::::







CGTCACCCCGATGCGCCCAGATCGGGGCTTCGCAGATAAAGCACGAACTGGCGGGCAAAACGTCGATCTCGGAGCCGGAAGGGCAATCAGCCGACCGTCGACGAAC




(SEQ ID NO. 678)







GACACCGGCGAGACCACTTAGGCAGTGACGGCCT






Clone Rv90




:::::::::::::Rv90SP6.seq:::::::::::::







CTTTTCNCGATGTCTCATGATNCCNANGGAGAACNNTGCNANCNCNGCCGCTGACNTNGCNCACCGCTNTGGCNGNGGTGACATTGGTGGTGGTTGCGGGCTGCNA




(SEQ ID NO. 679)







CGCCCGACTCGANGCCGANCCATNTNTTGCGGCCGACCGCNTNTCGTCTCNACCGCANNCCCNATCTCNGCCGCNCCCGGTGGANCTACNGCTNCTTCGCCATCTC







TCGCCNATGGCTCCNGCGNNTCGCNCAACGTNTGGTTTGGTNANCTGCCTACCTGGTCNT







:::::::::::::Rv90T7.seq:::::::::::::







GCTGCGCCAGTCGTTCGGTGCGGTCATGCCGTTGGACCNACCATCGGAGTTAGTTGCCGAACCGCGGACCACCGCAAGCACCCGGTCCTGGTCGCGCACCGCGTCG




(SEQ ID NO. 680)







GCCAACCGCTTGAGCACCACCACGCCGCAGCCCTCGCCGCGCACGAATCCATCCGCGTTGGCGTCNAANCTGTNGCATCGGTCGGTCGGTGACAGCGCCGACCACT







TGGACAGCGCGATGGCGGTGAACGGTNANTAGGTGACCTGCCNCCNCGCCCGCCAATGCCCACCTCCGCTTCACNCATGCGAATGGTCTGACACGCCNAGTGAATT







GCCACCAGCGACAACAAAAATCGGTATCTNCNGCGACGGCGGACACGCNATCCCNACTGATACTCGATCCGCCCCACCGCTTGNANCTCCGGGTTCCNGTGCTCAT







GTACCNTCATGTCGGTCTGCGCNCGATATTGACGATCGTGTTTCCCACGANNANAGANCCTCATCACGCCGGTTCGAGTGCCG






Clone Rv91




:::::::::::::Rv91SP6.seq:::::::::::::







CTGTGTGCGGNCGGCGCGATATCGGCCTTTTTACTAACCGAACCCGATGTGGGCTCCGATCCGGCGCGCATGGCATCTACNGCGACGCCGATCGATGACGGCCAGG




(SEQ ID NO. 681)







CTTACGAGCTTGAGGGTGTGAANTTGTGGACCNCCAACGGTGTGGTAGCGGACCTGCTANTGGTTATGGCGCGGGTACCGCGCAGTGAANGGCACCGAGGGGGAAT







CANCGCCTTTGTCGTCTANGCTGATTCTCCCGGGATCACCNTGGAGCGCNCCNCNANTTCATGGGACTGCGTGGCATCCAANACGGCGTGACCGGCTTCATCCNTC







NGGGTGCCCAAAGACAACTTGATCNGCNNGGAAGCGACGTCTGAANATCGCGCTGATCNCACTCAACGCCGGACGCTGTCCTACCGGCGATCGCACCGGANTTGCC







AANCGGCGCTNANNATNCGCGNGAATGNCCGTCCACNANTGCATGG







:::::::::::::Rv91T7.seq:::::::::::::







TGGGGTGCCGGGCGCCGAGTTGCGTCCCTGGGATCACGCAGAGTCGCCGGCGGCTGCCGTTGGGCTATGAATTGCACCGAGCCGGAAAATCCGCANCAAAACTGCG




(SEQ ID NO. 682)







AGTAGCGGCCTGCAGAAGTGCANCCTCGGCGAAACGGAGTACGGTGGACAACGAAAAGCGCCGCCGAACNACGCACTGGCCCGAGGGATTGGCGTCAATCGGCCCC







GCCCGTCGAACTTGGAAGANACANTGCGGTTCTACCGTGATCTGGTGGGAATGCTCCAACNNACCTTCNCCGAAAGCTACGGAAGCNACGGCGCGATNTTCGGCCT







TCCCAGCTCGACCTGACGCTGGAAATCG






Clone Rv92




:::::::::::::Rv92SP6.seq:::::::::::::







NGGCNGGGAAGTTAATGCCCTACTGGTTCNATGCTCNCACNTCNCCNGTGACNNCCTGCNCCGACCCGCCGAGGTCCTGNCCGTNACCACCGANCNGGCGATCCGG




(SEQ ID NO. 683)







GACTCTNGTACGCATCCAACANNGANCAACGTGCACGGGCGGAGTNGTNCCGCCACTTCGNCNATGACGGGGTCGATCCNTTCGACGTCCGTCGCCGCGTCGGTCG







AGTGGCGGTCACNCTCCNNGTACTCGACCNCACNGACGAGAGGACTCGANCCCATCTACGTGTGGACGAAACANATCTTCTGTCCNACGACTACACCACCACCCAG







GCCATCGCCGNCGCCCGCGANGCCCCTTCGACGCCNTACTGGTCCNGNGGNGGCGCTCTCCGGTTGTCTNNCNCNTGNCGTGTTCCTTCACNCACTGCCCNACATC







GANCCCGAGCNATNCNANGTCCGTCAATC







:::::::::::::Rv92T7.seq:::::::::::::







GGACACTGTTCGCGTGCCCCTCGTCAAAGCCGGAGTGGTCGTGCTGCGCCGGACCCGACCCGACCTTCAGCGGGGGTTCACAGCTCCGTGGGTGCCGTTACTTCCG




(SEQ ID NO. 684)







ATCGCCGCAGTGTGCGCGTGCCTGTGGCTGATGCTGAACCTCACCGCGTTGACTTGGATCCGGTTCGGGATCTGGCTGGTGGCCGGAACCGCGATTTATGTCNGCT







ACGGGCGCCGGCACTCGGCGCATGGCCTTCGGCAAGCNCNANANAACGCGACCCGGAGGTGTTGAACTAGCTTCGCCGCGTATTTACAAATTGCNTTATATGTCTA







CACATAAGACGCAAACTGCTCTATTGTCAANTCCCANCGTGGTGTGGCNCATGAAGATGTTTGG






Clone Rv94




:::::::::::::Rv94SP6.seq:::::::::::::







TCCTTCTCGGTATCGGTTTGGGCTGTCACCANCAGTTGGTAGTTCTTCACGTNCTGTTGTTCGAGCGTCNAGCCGTCGCGCGTGTCNANGTCNCCGGACGCGTATC




(SEQ ID NO. 685)







CCGCCAGGCCGGTCANGGTGCCCTTCCANTCCACGCCGCTGTGGTCGGCGAACGCTNATCTTCAATCGAGACCATCGCCAGCTTCATCNTGTTGGCGATCTTGTCN







NACGGCACCTCNAACCGGCGCTNCTAGTACNCCACNCNATCNTGTTNCCTTCNCGTCNACATCCTCGATNCCNCNTGCACTTTCCCTCGANCNCCTGGGCCGAGCC







GTTGGCANTNACCTCNGAGCCCCATTGGACATCANCCCANCCCGCCTGCGAACGGGAACGTCAGCNCNCTGGCGACAACCTGGCCAACAN







:::::::::::::Rv94T7.seq:::::::::::::







CACNCCGTGATCGCNAGCCCCNGTAGAAATNGTTGAGCCAGTTGGTGCGGCGCTCGTTGCCGGCGGTNATCTCGTCGAGCTCNTCTTCCATCGCCGCGGTGAAGTC




(SEQ ID NO. 686)







GTACTCGACNCGCCGACCNAAATGCTGCTCNAGCAGACCGGTTACCNNNAACNCCNCCTCNTGACNGCACCAGTGCNCTGCCCTTCTTGTGCACGTACCCGCNATC







CTGGATGGTCTTGATGATCNACTANTNTGTCGACGGGCGGCCGATGCCCATCTCCTCNAGCGCTTTGACCAGCGACNCCTCGGTGTATCGGGCCGGCGGGTTNGTG







GCATGGCCGTCTGGGGTCANCTCNACNATNTTCANCCGTTGACCCGGGGTCACA






Clone Rv95




:::::::::::::Rv95SP6.seq:::::::::::::







TGGCCTTCTTGNCANGGGCNNACATNNGCTATNGCGAGCGTGTAACCGATCATCNTCCNGGCGACTGTGGCCTGANCGGCAAGGGTNGCCTNATTCNTCCTCCTGN




(SEQ ID NO. 687)







GGCATGGTTNCCACACGGAATGNCGGTAAGTCTGGTCGGCAACCTGGCCCGCTGCGGGTTGGGTTCGGATTCGCTCGGCTANTAAGGTGCTCGCCTGGTGTNACNA







CTAATCNCNATATACNCTTANCGGGAGTNGNCGTCCCGATCCTNGCCCTGCCGCNGGCGATCNCGTTCGCANCACCGCCACCGGAACTCNCAANGTGCGCTCATCG







GGCTCTACGCGCCATCTTCCCCGGATTCTTCGCGGCNGNGTNCCGNGGGACCCCGGACTGTGACNGGCCCAACGGCTCATCATCG







:::::::::::::Rv95T7.seq:::::::::::::







CCGGATAGCGGTGTCTGAACTTCGCCCGTTCCCTCCANCGCATTGAGCTTCAGCCCGACCGGCAGGTNNGGAGTCGGCATGCGGTCCTTCGCCCCGACCCCGCTGG




(SEQ ID NO. 688)







CTAAATANCCACCCCCGAGCGCGGTCACGGTCTTTGCACCGGGACGACGCATACCGGCAGCGCGAACATCNCCGCGGGCTGCAGCNTGAACGTCCAATACCANTCN







AACAGTGTCCGCGCGTNAAAACCCGANCCGGCGGTCGCTTCNGTAATCAACGGCTCCTGCGCAACCAGCTGCAAGTCGCCGGTGCCACCGGCGTTGACGATCTTCA







TGTCTGCGANCTCGCGCACCAGCTCGACGGCCCGGGCA






Clone Rv96




:::::::::::::Rv96SP6.seq:::::::::::::







CCTCCCGACCACATACAGGCAAAGTAATGGCATTACCGCGAGCCATTACTCCTACGCGCGCAATTAACGAATCCACCATCGGGGCAGCTGGTGTCGATAACGAAGT




(SEQ ID NO. 689)







ATCTTCAACCGGTTGAGTATTGAGCGTATGTTTTGGAATAACAGGCGCACGCTTCATTATCTAATCTCCCAGCGTGGTTTAATCAGACGATCGAAAATTTCATTGC







AGACAGGTTCCCAAATAGAAAGAGCATTTCTCCAGGCACCAGTTGAAGAGCGTTGATCAATGGCCTGTTCAAAAACAGTTCTCATCCGGATCTGACCTTTACCAAC







TTCATCCGTTTCACGTACAACATTTTTTAGAACCATGCTTCCCCAGGCATCCCGAATTTGCTCCTCCATCCACGGGGACTGAGAGCCATTACTATTGCTGTATTTG







GTAAGCAAAATACGT






Clone Rv9




:::::::::::::Rv9SP6.seq:::::::::::::







CTTCACNTCCGTACGGCTCGGGTACGCTTCGGTCNCATTGTGCGAGTGATAGATGACGACCGGGACCTCGTCGGCATCTTCCATAGCCCGCCACACCTTCAGTTGC




(SEQ ID NO. 690)







TCACCGGAATCCAACCGGTANAAGGTCGGCGANCGCTCNGCATTGGTCATCGGGATATGCCGCTCGGGACGGTCANAGCCCTCGGGTCCGGCCAGCACTCCGCAGG







CTTCGTCGGGGTGGTCGCGACGCGCATGGGCCACCATCGCATTCACCAGGTCTGCGCGAATCACCAGCACGTANACGGTTCCTTTCCTAAGCAACACCGAANTTTC







AGGACCCGAATGCTCCGGGAAACATGTCACGGTAGGTCGGTATTCCGGCTACCGGCTGANCATTGAGCACGCCGGCCAGCACCGCACGAACCAGGCAATCAGCCGC







CGCCGCACCCGACCGCGG







:::::::::::::Rv9T7.seq:::::::::::::







CAGGCATGCAAGCTTGATGCCGCCGAAACCGAGCGTGAGCACGCCGCCAGCCACCACGCGCGGGTCGGGCGCCGGGCCCGGGCCGCCAGGCTGCTCCGCTCGGTGA




(SEQ ID NO. 691)







TGGCACGCCACCGCGACACCACCCGGCTGCGCTACGTCGAGCCATACCGGGCGGAGCTACATCGGCTCGGCCGCCCAGTGTTCGGGCCCTCTTTCGAGGTCGAGGT







CGATACCGATTTGCGCATCCGCAGCCGCACCCTGGACGACAGAACCGTGCCCTACGAATTGCTTGTCGGGCGGGGCCAAAGAACAGCTTGGCATCCTGGCGCGATT







GGCCGGCGCGGCGCTGGTCGCCAAGGAAGACCCGTTCCGGTGCTGAT






















TABLE 4









End sequences of the polynucleotide inserts cloned in the named






recombinant BAC vectors contained in the I-2049


M. bovis


strain Pasteur






genomic DNA library.






RvXXXSP6 corresponds to the SP6 endsequence of the clone RvXXX;






RvXXXT7 corresponds to the T7 endsequence of the clone RvXXX.






RvXXXIS 1081 corresponds to a region located close to a copy of the IS1081






repetitive sequence (Insertion element)






The character <<->> denotes an uncertain base residue.











Clone X0001






::::::::::X0001SP6.seq::::::::::






AAG-






TCGGGTTTCCACACGCGCGGTTTGACCCTAGTCATATGTAATCATGTGTACCATGTGCGGGCGCTTTTCGACGGC






CGCGAACCACCGGA-ATTTCCTGTGATTTCACTGCATGCGTACCATCTGGCACAATTGAGCA-TTGTCT-TCGCGG






TGGTCGG-CGGGTTGCGTGCCGCCTGCTGCGA-ATGCACCA-TAAGCCCGAACCCACCGGCTTGGTGACCACCGC






ACGCTGCGTGTGGGGGGTAACCACTCCGCGACCCCAAGGATGGTCATTTCCAATGAACCGGCTGGACTTCGTCC






A-A (SEQ ID NO. 692)













::::::::::X0001T7.seq:::::::::::






GTCGCGGTTCGATCGACCCGATCTTCACCTCGTAACCTCGATGCTTAGCAGGATCCAGCTTGACCGCGTTTGGCT






CTACCCACTCTTTGAGTGGCGCCGTCGCCTGTGCCCCATCGGTGTTCATGACGAACGCTTCGAAAGACTTCCTCT






TGTGAGCCGGAATGTCTGCGTAAAGAAGTTCCATGTCCGGGAAGTAGACCCGGTCGCCCTCCACGTGGTACTCC






TTCGAGGTCCGCTTCTCGCCGGATCCGATAAACACCGGCCCCAGGCACCGCAGCGTGAGTTCGAACGGCTTCAG






GTAGGTGTTCATGCGGCGGACTCCGGGAGTGCGAGAAATAGCGGTCGCGCGTAGCTGTAGACCGGATGGTTTCC






GCCCAGGCTGACGTCGAAGATGCCTCCTTGGAAGGGGCGCGA (SEQ ID NO. 693)













Clone X0002






::::::::::X0002SP6.seq::::::::::






AACTCAAGTTTTTACGGTGATCGCGCATCACCTGGTTCATGAACTGGAAGCAGCGCAGCGCTTCCTTTTCGGCCG






CAACATGAGCCAGCCTCTCGTCGGCGGTCGGGTGCAGGTGCTCGGGCAGCTCGGCCGCGACAGCCGCCTGACC






CTGAAACCAGCTTCCATATCCCGCGAC-






AACGACGCCAGTCCGCTACGTAACCCCTCCGCGACTGTCCATGGACAACAGCGCGTTCTCCACCGACCGGGCCC






GGGTGT (SEQ ID NO. 694)













::::::::::X0002T7.seq::::::::::






GTGCAGGTTTCGACAATGTGGTGCCGGTTCGGCGGCTACGTGCCATCGAGACACTGGCGCA-GCTATCGCACCC






GTTATCGGCTGCGAGCAAATCGCGGTATGCGTTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCA






CGACGGAAAGACGCAGATCGCCGTCAAGCATGTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCA






TGTTTGGTCGCGATGCCTGGCGCCCGGCCGGCGTGGTCGTGGTCGGCTCGGATAGCGAGGTCAGCGAATTCTCG






TGGCAGCTCGAAAGGGTCCTGCCGGTGCCGGT (SEQ ID NO. 695)













Clone X0003






::::::::::X0003SP6.seq::::::::::






TTCGAGTCATGCGCCCGCCTCGACCACGAA-ATGCACGTCGGGTTCGATCGACCCGATCTTCACCTCGTAACCTC






GATGCTTAGCAGGATCCAGCTTGACCGCGTTTGGCTCTACCCACTCTTTGAGTGGCGCCGTCGCCTGTGCCCCAT






CGGTGTTCATGACGAACGCTTCGAAAGACTTCCTCTTGTGAGCCGGAATGTCTGCGTAAAGAAGTTCCATGTCC






GGGAAGTAGACCCGGTCGCCCTCCACGTGGTACTCCTTCGAGGTCCGCTTCTC (SEQ ID NO. 696)













::::::::::X0003SP6.seq::::::::::






GTCATGTGTACCATTTGCGGGCGCTTTTCGACGGCCGCGAAACACCGGAGATTTCCTGTGATTTCACTGCATGCG






TACCGTCTGGCACAATTGAGCAGTTGTCTGTCGCGGTGGTCGGCCGGGTTGCGTGCCGCCTGCTGCGAGATGCA






CCAATAAGCCCGAACCCACCGGCTTGGTGACCACCGCACGCTGCGTGTGGGGGGTAACCACGCCGCGACCCCA






AGGATGGTCATTTCCAATGAACCGGCTGGACTTC-TCAACAA (SEQ ID NO. 697)













Clone X0004






::::::::::X0004T7.seq::::::::::






AACAGCGCGGTTGAACTGATAGGTGCGGCCCGGCTCGAGCAGGCCGGGCCATTTGTTCGATGCGGTTACCGAAA






GATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGCCCAGTGCCCGGCGTTGGCCGCCGCGGCGACGATCT






TGGCGTCCACGGTGGTCGGGG (SEQ ID NO. 698)













Clone X0006






::::::::::X0006T7.seq::::::::::






GCATCTGGGCTGGCGGTGGTTCGCCGCTCCGAAGCCGTCGAACACCATCGCCAGCGCGGCTTCCACATCAACGA






CCATTTCGGCCAGCTTGCGGCGCATCAGCGGCTTGTCGATGAGCGCCCCACCGAATGCCCGCCGCTGCCCGGCG






TA-CACAGCGATTCGACCAGCGCGCGGCGCGCGTTGCCGAGGGCGAACGAAGCGGTGCCCAACCGCAATCTGTT






GGTCAGCTCCATCATGCGGGTGAGTCCCTTGCCG (SEQ ID NO. 699)













Clone X0007






::::::::::X0007SP6.seq::::::::::






ATCGGTTTCCAGCAACAGCCGATCGACGGCTTCGCCCA-GGCCGCTCCCGGGCGACCCGACCATTGCTGTCGCC






GCGTAACGCCATCACGGATGACGCGCAGTTCGTCGCTGTCTAGCTCCACCATCGCCTGCACACCGGCGGCCAG-






ACCCATTGGCCGTCGCACTCGTA-






AGCAGGTAATCCTCGTCGACGGACTCGGTAACCACCGCCGCCAGCTCCGCTGCCAGGTCGGCGGGGTTGACACC






GGCGGGCATCGGGATGGACGACGACGCGGTGCTGACGGCGCCTGTC (SEQ ID NO. 700)













::::::::::X0007T7.seq::::::::::






AGCGGTTTCCCA-GCGATGTGCTGTGAGCGCCGCACCACCAGCGCCGACGCTAAGGATGGAACGCACGGCAT






CTTCTGACGCGTAACCGCGTTGTGATCGCGAGCTGAGGAGACGGTATGGGGGAGGGTTCTCGGAGGCCATCTGG






GATGTTGATGTCTGTCGATCTTGAGCCGGTGCAACTCGTCGGCCCGGACGGTACGCCGACGGCCGAACGCCGCT






ACCACCGTGACCTTCCTGAGGAAACGCTGCGTTGGCTCTACGAGATGATGGTGGTCACCCGCGAGCTGGATACC






GAATTCGTCAATCTGCACG (SEQ ID NO. 701)













Clone X0008






::::::::::X0008SP6.seq::::::::::






CAAGCTTCCACAGGTAGGGATCGAGGAACAGCGCGTTGAACTGATAGGTGCGGCCCGGCTCGAGCAGGCCGGC






CATTTGTTCGATGCGGTTACCGAAAATCTCTTCGGTGACCTGCCCGCCGCCGGCCAGCTCGGCCCAGTGCCCGG






CGTTGGCCGCCGCGGCAACGATCTTGGCGTCCACGGTGGTCGGGGTCATGCCCGCGAGCAGGATCGGCGAGCG






GCCGGTCAGCCGGGTGAACTTCGTCGAAAGCTTGACCCTGCCGTCGGGGAGGCGAACCACGGTCGGTGCGTAN






CTCCACCAAGCCCGGGCAACCTCGGGGGTGGCGCC (SEQ ID NO. 702)













::::::::::X0008T7.seq::::::::::






TGGACCTCATGACAACGCGGCGGCGATTACCCCCGCTACCGCCAGCAGCATGACGGCGGTAGCGAACACCGCC






GGATGCAGCGCAGGTGCGTCGATGTGCTCACGGAATCGCCCCGGCACCGCGATCTCGAGGATCACCAGTGCCAC






CCCCTGCAGCGCGACACCGACGATTCCGTACACCGCCACGCCGATCAGGCCCTGGGCCAGCTGGCGTATATGGC






GGCGATGGTGACGATGGCCAGCGCCACATACATTGTGGCGGCCAGAACCACGGCGTTGGGGCGGCGGTCGATG






AACACTAGGCGACGCAGATCGCCCGGGGTCAACAGGTTGACCATCAGAAAGCCTGCGA (SEQ ID NO. 703)













Clone X0009






::::::::::X0009SP6.seq::::::::::






TTTGGTGCGGCCGGCAATCAACTTC-






GCTC-CAGCGGTITCCCAGGCGGGATGTGCTGTGAGCGCCGCACCACCAGCGCCGACGCTAAGGATGGAACGCA






CGGCATCTTCTGACGCGTAACCGCGTTGTGATCGCGAGCTGAGGAGACGGTATGGGGGAGGGTTCTCGGAGGC






CATCTGGGATGTTGATGTCTGTCGATCTTGAGCCGGTGCAACTCGTCGGCCCGGACGGTACGCCGACGGCCGAA






CGCCGCTACCACCGTGACCTTCCTGAGGAAACGCTGCGTTGGCTCTACGATATGATGGTGGTCACCCG






(SEQ ID NO. 704)













::::::::::X0009T7.seq::::::::::






CGCCCAGGGCCGCTCCCGGGCGACCCGACCATTGCTGTCGCCGCGTAACGCCATCACGGATGACGCGCAGTTCG






TCGCTGTCTAGCTCCACCATCGCCTGCACACCGGCGGCCAGGACCCATTGGCCGTCGCACTCGTAGAGCAGGTA






ATCCTCGTCGACGGACTCGGTAACCACCGCCGCCAGCTCCGCTGCCAGGTCGGCGGGGTTGACACCGGCGGGC






ATCGGGATGGACGACGACGCGGTGCTGACGGCGCCTGTCGCGACGCTGAGCTCGGACACAGCTAGTAAATGTA






GCCTAACCTACTTAATGGGTCGCAGCCCCCCGGGGTCGTCGCATGTCCAACGTTGCTCGACTGGAAGAAAATGC






TCGTCGGGGAGCAAATGGCACC (SEQ ID NO. 705)













Clone X0010






AATACTCAATCCTTGATCGGTTTCCAGCAACAGCCGATCGACGGCTTCGCCCAGGGCCGCTCCCGGGCGACCCGA






CCATTGCTGTCGCCGCGTAACGCCATCACGGATGACGCGCAGTTCGTCGCTGTCTAGCTCCACCATCGCCTGCA






CACCGGCGGCCAGGACCCATTGGCCGTCGCACTCGTAGAGCAGGTAATCCTCGTCGACGGACTCGGTAACCACC






GCCGCCAGCTCCGCTGCCAGGTCGGCGGGGTTGACACCGGCGGGCATCGGGATGGACGACGACGCGGTGCTGA






CGGCGCCTGTCGCGACTCTGAGCTCGG (SEQ ID NO. 706)













::::::::::X0010T7.seq::::::::::






GGATGTGCTGTGAGCGCCGCACCACCAGCGCCGACGCTAAGGATGGAACGCACGGCATCTTCTGACGCGTAACC






GCGTTGTGATCGCGAGCTGAGGAGACGGTATGGGGGAGGGTTCTCGGAGGCCATCTGGGATGTTGATGTCTGTC






GATCTTGAGCCGGTGCAACTCGTCGGCCCGGACGGTACGCCGACGGCCGAACGCCGCTACCACCGTGACCTTCC






TGAGGAAACGCTGCGTTGGCTCTACGAGATGATGGTGGTCACCCGCGAGCTGGATACCGAATTCGTCAATCTGC






AGCGCCAGGGGGAAGCTGGCGTTGTACACGCCCTGTCGCGGGCAGGAAGCCGCGCAGGTGGGTGCGGCGGCTT






GCCTACGCAAAACCGACTGGTTGTTCCCC (SEQ ID NO. 707)













Clone X0012






::::::::::X0012SP6.seq::::::::::






ATCACGACAACAGCGACGGTGTGTCGGATCAGCGGCCCCCGTTGCCGGGCAATGTTGAGGCGTTTCTGCGTCTG






GTTGAGGCCGGCTGGGAC-






CCGAGGTGGCTCGTCGGCCACATGGGCAGCACACCACCGTGGTGATGCATCTAGACGTGCAGGACCGTGCCGCT






GGCCTGCA (SEQ ID NO. 708)













::::::::::X0012T7.seq::::::::::






GCGGCTACGTGCCATCGAGACACTGGCGCAGGCTATCGCACCCGTTATCGGCTGCGAGCAAATCGCGGTATGCG






TTCTTGAGCATGAGTCGGCGACCGTCGTCATGGTCGACACCCACGACGGAAAGACGCAGATCGCCGTCAAGCAT






GTGTGCCGCGGATTATCAGGACTGACCTCCTGGCTGACCGGCATGTTTGGTCGCGATGCCTG






(SEQ ID NO. 709)













Clone X00013






::::::::::X0013T7.seq::::::::::






TACAAGCGGCACCTCGCCGGTGAACTGACCGTTCGCACGCTGCGCACCGCCGCCGGGCGCGTGCTCGGCGCGC






CGGCGGCCCCCGAGGCCTGAGAGGGGAACCAACCATGCAGGTGAACATGACGGTAAACGGCGAGCCCGTCACC






GCCGAGGTCGAACCCCGGATGCTGCTGGTCCATTTTCTCCGTGATCAGCTGCGGCTCACCGGAACTCACTGGGG






CTGTGATACCAGCAACTGCGGGACATGCGTGGTGGAGGTCGACGGCGTGCCGGTGAAATCCTGCACGATGCTCG






CCGTGATGGCCTCCGGGC (SEQ ID NO. 710)













Clone X0014






::::::::::X0014T7.seq::::::::::






AGCGGCTGGTTACGACTCCCTGTITGTGATGGACCACTTCTACCAACTGCCCATGTTGGGGACGCCCG-






CC-TCCGATGCTGGAAGCCTACACTGCCCTTGGTGCGCTGGCC-C-GACCGAGCGGCTGCAACTGGGCGC-






TTGGTGAC-GCCAATACCTACCGCACCCC-ACCCTGCTGG-CAAA






ATCATCACCACGCTCGACTTGGTTAGCGCCGGTCGACGATCCTCGGCATTGGAACCGGTTGGTTT-






(SEQ ID NO. 711)













Clone X0015






::::::::::X0015SP6.seq::::::::::






ACGCGCGCCGATCATATCTGCTATGGATGTACAATTCAGCTCTTGCTGTTATACCAGTATATGGTGTACTATTTG






ATCTATGCTGACGTGTGAGATGCGGGAATCGGCCCTGGCTCGACTCGGCCGGGCTCTGGCTGATCCGACGCGGT






GCCGGATTCTGGTGGCGTTGCTGGATGGCGTTTGCTATCCCGGCCAGCTAGCTGCGCACCTCGGGTTGACCCGA






TCGAATGTGTCCAACCATCTGTCGTGTTTGCGGGGCGGGCTGGTA-






TCCCAACCTATGAGGGCCGGCAGGTTCGGTAT (SEQ ID NO. 712)













::::::::::X0015T7.seq::::::::::






CCGCGCTGCTGCTGACGTCGGTCGAACGTGCGACACGTCTGCGAATACCGGCCGAACGCTGGGTITATCCACAG






GCTGGCACCGACGCCCACGACACACCGGCCGTCGCCGACCGCCACCGACTGCATCGGTCGACGGCCATTCGGAT






CGCCGGTGCCCGGGCGCTGGAACTGGCTGGGCTGGGGCTCGATGACATCGAATACGTCGACCTGTATTCGTGCT






TTCCCTCCGCTGTCCAAGTCGCCGCAATCGAACTCGGCCTGGACACCGACGATCCTGCCCGCCCGCTGACCGTC






ACCGGGGGCCTGACCTTCGCCGGCGGGCCGTGGAGCAATTACGTCACGCACTCCAT (SEQ ID NO. 713)













Clone X0016






::::::::::X0016SP6.seq::::::::::






CAGGCGTGCAATGACCTGCACTGCGCCGGA-A-TCCCTAACCCACTAAACCGGGGCCGCTCACAAGCCGTGCAGC






TCGGTCAGCGTCAGGTGCGCGACCAGGAA-






TAAATGAGCAGACCCGTGCCGTCAACGATGGTGGCGATCATCGGCCCCGAAACGATGGCCGGGTC






ATGCGCAACTTCTTCAGCAGCGGCGGAAGGACGGCACCACCAGCGAC-ACCACACCACGAT






(SEQ lD NO. 714)













::::::::::X00016T7.seq::::::::::






GCGAA-CACTTCGTCAACTTCCAGGGCTGCCCGCACCAAGTATTTCGACGAGTATTTCCGTCGGGCCGCCGCCGC






CGGCGCGCGGCAGGTGGTCATCCTGGCGGCGGGGCTGGACTCGCGCGCGTACCGGCTGCCTTGGCCCGACGGG






ACCACGGTTTTTGAGCTGGACCGCCCGCAGGTCCTTGATTTCAAGCGCGAGGTGCTCGCCAGCCACGGTGCCCA






ACCGCGCGCCCTGCGCCGCGAGATCGCCGTCGACCTGCGTGACGATTGGCCACAAGCCTTGCGGGACAGTGGTT






TCGATGCGGCTGCACCGTCGGCATGGATTGCCGAAGGGCT (SEQ ID NO 715)













Clone X0017






::::::::::X0017SP6.seq::::::::::






TTGGGC-TTGCCC-CAATA-GGCCCCAATCAAAAGCCGAGCAGGTGGAACCTA-CGCATTCGCCTC-TCGT-TGTGC






ACCCGAGCCATCGCACGCGCGGGAATTCCCGGAT-TC-CCGTATTCTCCGGCGGCCGGGCTAACCCATCCCA-GCC






GAACGGTTGGCTC-TGCCGTGGGTCCCGTGTTGGCCGATCGGGGCGTCACCGGGGGTGCTCGGGTGCGG






TGACCATGGC-AACTGCCCC-ATGGGCCGACCCTGGTGCAGATAAACCTG (SEQ ID NO. 716)













::::::::::X0017T7.seq::::::::::






TGGTGGAGGTCCCCACCAA-ACCCGGCCGTAACTCTGCTCACGGAAATGCGG-CAGGCCGCGCGTAGCACGTGGT






ATCCGCCATAAAGGTGCACCTTAAGCACGGCGTCCCAATTCTCGAACGACATCTTGTGGAAGGTGCCGTCGCGC






AAGATCCCGGCGTTGCTCACCACACCGTGCACGGCGCCGAATTCGTCAAGCGCGGTCTTGATGATGTTCGCTGC






GCCGTCCTCGGTGGCGACGCTGTCGGTA-TTGGCGACCGCCCGGCCCCCCTTGTCGCGAAATCTCGGCGACGAC






CTCATCGGCCATCGCCGAACCGGGCCCCCG (SEQ ID NO. 717)













Clone X0018






::::::::::X0018SP6.seq::::::::::






GCCGGCCAAACTGGCCGGCGGGGTTGCTGTC-TCAAGGTGGGTTCCGCCACCAA-ACC






CACTCAAGGATCGCAAGGAAAGC-






TCAAGGATGCGGTCGCGGCCGCCAAGGCCGCGGTCAAGGAGGGCATCGTCCCTGGTGGGGGA-CCTCCCTCATC






CACCAGGCCCGCAAGGCGCTGACCGAACTGC-TGCGTC-C-GACCGGTGACAA-GTCCTCGGTGTCCACGTGT-CTC






CGAAGCCCTTGCCGCTCCGTTGTTCTGGATC-CC-CCAAC-CTGGTTGGACGGCTC






GTGGTGGTCAACAAGGTCAGCGAGCTACCCGCCGGGCATGGGCTGAACGTGA (SEQ ID NO. 718)













Clone X0018






::::::::::X0018T7.seq::::::::::






CGAACCT-






AATTGTCCTGTAATGCCCAGCTCACCAA-GCATGGCTGGTGGCCGGGGCGGTGAAGCCGGCGTCTGCGGCACCG






TCCAACTC-ATGTGGAT-GCCGGAATGGGGATGTCCGG-ACGGCGAATCCGTA-






TTCGCTTGTCCCGTGAGGCCCAGGTGGATGGGGGGAAGGATC-TGGTGTCCGGGATGAT






ATGGGGCCGATGCCGCCGGTTGAAGTCCACTGGATCGGGAATTCGGGAATCGTGAT






CCGACGTTCAGGCCGAAC (SEQ ID NO. 719)













Clone X0019






::::::::::X0019SP6.seq::::::::::






CTAACGGAATGAAAGCCCTGGTGGCCGT-TCGGCGGTGGCCGTCGTCGCACTGCTCGGTGTATCTTCCGCCCAAG






CTGATCCCGAGGCGGATCCCGGCGCAGGTGAGGCCAACTATGGTGGCCCCCCAAGTTCCCCACGTCTTGTCGAT






CACACCGAATGGGCGCA-






TGGGGAATTCTGCCCAGCCTCCGGGTCTACCCGTCCCAAGTTGGGCGTACA-CTCCCGCCGCCTCGGGATGGCC






GCTGCCGACCCGGCCTGGGCC-AGGTTCTCGCGCTGTCACCGGAAGCCGACACTGCCGGC (SEQ ID NO. 720)













::::::::::X0019T7.seq::::::::::






CCGCGGGACAC-CCTC-ATGCTGCCGCCATGGACGCGGTCGAACGCAAGCAGCTGATCGAGCTACAACGCCGCG






CGGAACGCTTCCGCCGCGGGCGTGACCGCATCCCGTTGACCGGGCGGATCGCGGTGATCGTCGATGACGGCATC






GCCACCGGAGCGACGGCCAAGGCGGCGTGCCAGGTCGCCCGGGCGCACGGTGCGGACAAGGTGGTGCTGGCG






GTCCCGATCGGCCCA-ACGACATCGTGGCGAAGATTCGCCGGGTACGCCGATGATGTGGTGTGTTTGGCGACGC






CGGCGTTGT (SEQ ID NO. 721)













Clone X0020






::::::::::X0020T7.seq::::::::::






CTCTGGGACCGGCCACGGTGCC-CCGGCGTTCCCGGACGTGCTGCGCCAGGTGTCCGGCGGCCGCGTGCATGGT






GTTCCCGGATCGGCCGCTGGCCAGAGCCCACCGGTGAATCTGGCGCCTGGCCGACCACCGTGCGCCGTAGGCTT






GCGATCGTGCAGCGCTGGCGTGGCCAGGACGAGATCCCGACGGATTGGGGCAGATGCGTGCTCACCATCGGGG






TATTTGACGGCGTGCACCGCGGGCACGCCGAACTGATCGCGCACGCGGTCAAAGGCGGC (SEQ ID NO.722)













Clone X0021






::::::::::X0021SP6.seq::::::::::






AATACTCAAGCTTTCGTCAGTTCATTGCGCCAGCAGACCAACAA-AGCATCGGGACATACGGA-TCAACTACCCG






GCCAACGGTGATTTCTTGGCCGCCGCTGACGGCGCGAACGACGCCAGCGACCAC-TTCAGCAAATGGCCA-CGCG






TGCCGGGCCACGAGGTTGGTGCTCGGCGGCTACTCCCAGGGTGCGGCCGTGATC-ACATC-TCACCGCCGCACCA






CTGCCCGGCCTCGGGTTCACGCAGCCGTTGCCGCCCGCAGCGGAC-






ATCACATCGCCGCGATCGCCCTGTTCGGGAATCCCTC-GGCCGCGCTGGCGGGCTGATTAAC






(SEQ ID NO. 723)













::::::::::X002lT7.seq::::::::::






TGCCGCGGATTTGGCTGGGTGCCCAATATTCAGAATCGGGCCTTTCTTTTTGCGCGACAATAAGGTCACAGTAAA






CCCTCGTTTTGTGAGATGCGGCCCGGGCCGGGCGAA-TCGACCTCGAGTGAATGGATCTCGAGTGAATGGACAG






GGCATCGCCTACGAGTCGCATCCCCATCCAACAGACCGGTGCTCTTGCATCGGACCCTGAAGGTCCCGCACGGA






GGGTGTGGTTGCCGGCGCGGGGTCACGGTGCGGTAGCGACGTAGTGTTTGAACGAATTTCTTGATGCTCCAACC






TGTITGGTGTTCAATCCAGTTCT (SEQ ID NO. 724)













Clone X0175






...X0175SP6...






AA-CTTGCGCGCTCGGCCGGGTC-AGCATCCAGCTGCTCGGCAAGGAGGCCAGCTACC-TCGCTGCGTATGCCCA






GCGGTGAGATCCGCCGGGTC-ACGTCCGCTGCCGCGCGACCGTCGGCGAAGTGGGCAATGCCGAGCAGGCAAAC






ATCAACTGGGGCAAGGCCGGTCGGATGCGGTGGAAGGGCAAGCGCCCGTCGGTCCGGGGCGTGGTGAT-AACC






CGGTC-ACCACCCGCACGGCGGTGGTGAGGGTAAAACCTCCGGCGGCCGTCACCCGGTTAGCCCGTGGGGCAA






(SEQ ID NO. 725)













...X0175...






A-TCGAAAGTGACCATCTCTACCTTGAGTGCCATACCGCCCGACCCTATGCCTCGGATAGCTCGGCGGAAAGAAA






CGCTTGCAGTGCCGCCGAATAGGCGGCTACGTCGTGAGCGCCCATCAACTCTCGCGCGGAGTGCATCGCCAGCT






GGGCGGCGCCGACGTCGACCGTGGGGATTCCGGTGCGCGCCGCGGCCAACGGCCCGATCGTCGACCCGCACGG






CAGATCGGCGCGATGTTCGTAACGCTGCAThGGCACTCCCGCGCGCTGGCAGGCCAGTGCGAACGCCGCCGCG






GTGCGTCCG (SEQ ID NO. 726)














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743




1


12732


DNA


Mycobacterium tuberculosis



1
acctgcgctt gcagagatca aatagggcgc atgggtcagc atagtacagg tcgtcgcgca 60
tctttgatgc atcggaataa gatgtcaggc aattaaaaga gaagccacgg cgactcgcgg 120
cattcagcat gtcgagcgtc gcttcgatgt gagcgcacca ttccgtgtcc aacgatttca 180
gacgaacatt gaatattcca ctcgcgacgc tatagtccgc ctcccgatct atgcgcgccg 240
cgcagatgaa gtctgcgttc gcccgacctt cgaaacgtag tgcggccgcg cgcaccattt 300
cgggggagac gtcgatgccg gtgtaatcag ttttgaagcc acgcgcatct aggtagtcca 360
gtagagcccc atagccacag cctagatcgt tgatcgaaaa tgggtccgcc gcattgacaa 420
tgcgcaccag ctggtcaaag cgcaacgcct gcccggcttc gccgttccaa tcgacgccgc 480
gcgggtgccg tgtgcttcga gtttcgatgc gtagtaacgg gccacgtcag cgagcatggt 540
cgttgcgtct tccgccatga agctgcctca cgatttgtgt gtgtgggcgt cggtgcgtgg 600
gtccgagact ataccttcaa cagttgcatg ccgaggctgc ggcgggcaat gacccaaaaa 660
cccgccggca cggttcgccg agcaaggaag cgtggagacg atagataatt tcactggcga 720
cagtacctca aatagtccgg agcctcggct ccgacgttaa agagcagatc cagaatcgac 780
acggcgggct cgaaccctcc ccacaattgc ttataatcgc ggtagccgtc ataatcgaac 840
caagttaccc ggatgctaag ttcgtcgaac acgcgctcat cgacatacga acgggctgag 900
gggccagaga catattcggt cgctgcggcc tgttggcaga ggttggccag tctctcggtc 960
ttgccgtcgg ctaattcgta gtcccacgaa tttgccagtc gcgtgctgat accgagataa 1020
ctgcaaatcg cattcaatag acgcctgttg agtaaggaaa gattcgtgtg ctgttcttcg 1080
aggtaaatcg gcgcgagcca gtcagcgatc tccgcaaaat gagcggccgc gctgtagttg 1140
aattctagtg cccgccagtg cgctttcgcc caatcggtgc cgtcgatcag cgtctcacgt 1200
atcttttgat ggaaacgtcc cttcacctgg acgggaacag ttatccactg taacccctgg 1260
ctcgttttga tccgatttct gtttcgccaa tcacgcttgg tatattgcat gtcatcatag 1320
atgatgaatt catcgacgaa tgcaatcagg tcaaaatatc ctcgccaagg tatgtaattt 1380
gattgaacaa tcgcgacttt cttcaacgcg gtgtctccaa tttagaataa caaatacgtc 1440
gcgcccgcga cagctccgct ggagcgagtt caagcgattc tgcgacatat tcaatatggt 1500
gctcgggaag gccaggatgg gccgcgaccc ggggcgtccg gtgcgcgatg aacgtcgcat 1560
cgtctcctgt gagataattg catccgatca tatagggctg gctgcggcta ggttgctggc 1620
aaaaagatat cgcggccgat ccgtttctgg ttttgtcttg atgatcaaat ccgcttccgt 1680
tcacgagatc gattcctggt cttcccccag cgtcgcgatg tcgataggtg tcgcgctttg 1740
ttcgtacccg cactacgcgg cggcgagaac ctcgccaccg aatcgggatt ggggggagga 1800
taccactcgg tcgaggcccg tcaccggcct tctagcgggt tgaccatcag tgtttgcagg 1860
gccctatccc ggtatggcgc accacgggat cggcagcgtt ccggttgctg gcgtggtacc 1920
tcgttgtggc gccgtggtcc atgtcgattg agtgcgtgga tcagtgtaaa ccgttgcgcg 1980
ccatgttctg taggcactgg ttcgggttgt ggttaggctg cacggttggc aggttaccaa 2040
ccactgagcc cctgggcgga tgtgagctcg gactccgcct atggggtgta attttggcag 2100
attgggccgg gtccccgtgg tgaggactcc tcaaccggat tgggtaagca tgaggtggtg 2160
ctggcagcgg tgtcctggtc gctctcccga gtaggcccgt tgtgactgtc atgtgggcga 2220
gcgggtttgc gcgcgtagga gacgatgatt actacgcacg tgaccaacca caagaacggt 2280
gcccatgtca ccgtggtgaa aacgagtggc gtggtaccga ctaccccttt ggctcccagc 2340
tgtccataga gcggcacgta gaacggctgg cccgggaccg cgacgttgac gatgctcagc 2400
gccacggcca aactcacgca gacgccgacc gcgcggcggc ggtctccatg ggctgcgagt 2460
tggtcgaata tcccagcacc aggaggcccg ttggggtctc gggctaccag tgcagcgatt 2520
ggcaagacga aaacgagata gtagaaggcg acgtccgcgg gggagaaggt ggcggtggcg 2580
agcaacacaa tccccaccat gacaggcggg atacggcgtc cgagcgccag cacggcgacc 2640
acgactatga ctaggacagc aaacccgatc tgcgttcgcg gaccagtgag gaaaccctct 2700
gggatcttgc ccgattgata gttcttgatg ctatcgggga tcagcaggag tgccttgcca 2760
aaggacacgt tccgcgggtc tcgaagccct ccgaacgaac tattgaactt gatgatgccg 2820
tggatcgact gtgcgatcgt ccccgggaag cctcgtggcc acaacagaaa ggctgcgata 2880
ttggacacca ccacgccggt gatcccgata ccagcccacc gccattgtcg agccgccaac 2940
aacaccacgc cgagaacgac gaactgcggc tttaccagga cggccaagat caccgtgatg 3000
gtggcgaggc cccaccgctg tcgggacaac gccacgaagt aagccagcgc gatcggtacc 3060
acgaaccctg tcgagttgcc tcgatcgatg accccccacg ccgggatggc cgcggcgccc 3120
agtgtcacga agatgaccac tcgctccaga ccacgtgccc cccgggccgc ccagatggcg 3180
ggagatatga ccgccatcgt tagggcgacc aggtaacaga tcagccccaa gcgcggcgca 3240
cccagccaat ggctgggtag tccgaaaatc gcatacggta tgcgggcggg ggcccatgca 3300
gcaaccgcgg tcggctggta atcggcgggt agcgagatca ggtagtccgc gggattgggt 3360
tgaatcccgg cggcggcgac catggcgtag tcgctgaagc agtgccgacc gatattcatg 3420
ccccaatcaa gccaacagtc cccagggact accaaaagag tggaaaagac gtcgaccgcg 3480
taccactgac tgagggcgta cgccgtcgcc gccgaaatca ccgacgccag caggatggtg 3540
ccgagcatga gggtgcgctc ggattgggag ccgatcgccc agagccgctc ccggctcgcg 3600
gtcacggcac cgcgcaacac ctccgggggt cgcttcatct ggattctcct cggttctgcg 3660
cgaaacggta gcagagcgcc atggttgcca acgcggtcgc cgggcagtct agaccggatc 3720
ttcctcgtgg caaccgacaa caggacgtcg ttgccgaaag ggcgctgggc accgacatct 3780
aggatgaacc cacagccacg ccccgacgtt atgccatggc gaagagcgac cggcaggagc 3840
gggaacccag tgaagcgagc gctcatcacc ggaatcacag gaccggacgg ctcgtatctc 3900
gctaagctcc cgctgaaggg atatgtggcc gctggtagcc cggccgaggt ctatttctgc 3960
tgggcgacac ggaattatcg cgaattgtat gggttgctcg cggtcaacag catctggttc 4020
aatcacgaat caccgcgtca cggcgagaca ttcatgactc gtaatcctgc accatatcgc 4080
ggtcggcaac gaggcgctga tcgatgcgca gacgctgatg cgccggccca cccggatagg 4140
tatcagtatt ggggcgttcc ggccagcgta cgaggcgtga tcgaccgcgc aatgggtgtt 4200
tgcgttgagt aataatctga accgtgtgaa cgcatgcatg gatggattcc ttgcccgtat 4260
ccgctcacat gttgatgcgc acgcgccaga attgcgttca ctgttcgata cgatggcggc 4320
cgaggcccga tttgcacgcg actggctgtc cgaggacctc gcgcggttgc ctgtcggtgc 4380
agcattgctg gaagtgggcg ggggggtact tctgctcagc tgtcaactgg cggcggaggg 4440
atttgacatc accgccatcg agccgacggg tgaaggtttt ggcaagttca gacagcttgg 4500
cgacatcgtg ctggaattgg ctgcagcacg acccaccatc gcgccatgca aggcggaaga 4560
ctttatttcc gagaagcggt tcgacttcgc cttctcgctg aatgtgatgg agcacatcga 4620
ccttccggat gaggcagtca ggcgggtatc ggaagtgctg aaaccggggg ccagttacca 4680
cttcctgtgc ccgaattacg tattcccgta cgaaccgcat ttcaatatcc caacattctt 4740
caccaaagag ctgacatgcc gggtgatgcg acatcgcatc gagggcaata cgggcatgga 4800
tgacccgaag ggagtctggc gttcgctcaa ctggattacg gttcccaagg tgaaacgctt 4860
tgcggcgaag gatgcgacgc tgaccttgcg cttccaccgt gcaatgttgg tatggatgct 4920
ggaacgcgcg ctgacggata aggaattcgc tggtcgccgg gcacaatgga tggtcgctgc 4980
tattcgctcg gcggtgaaat tgcgtgtgca tcatctggca ggctatgttc ccgctacgct 5040
gcagcccatc atggatgtgc ggctaacgaa gaggtaatga catggcgcaa gcgacatcgg 5100
gcattcgcgc ggcactttcg caacctgctg tgtatgaggc gtatcagcgg attgcgggcg 5160
ctaaaagcgg gcttgcgtgg atcacaaccg accccatcca gtcgttgcca ggcatgcgta 5220
ctctcgacct cggttgctgg ccagcggtga tacacagctc cccgccagtg gacgtgacat 5280
gtacgagaga cggcatgagc gcggaatgtg cgaccgtgcc gtcgagatga ccgacgtcgg 5340
cgctacggca gcccccaccg gacctatcgc gcggggcagc gtcgctcggg tcggcgcggc 5400
gaccgcgttg gccgttgcct gcgtctacac ggtcatctat ctggcggccc gcgacctacc 5460
cccggcttgt ttttcgatat tcgcggtgtt ttggggggcg ctcggcattg ccaccggcgc 5520
cacccacggc ctcctgcaag aaacgacccg cgaggtccgc tgggtgcgct ccacccaaat 5580
agttgcgggc catcgtaccc atccgctgcg ggtggccggg atgattggca ccgtcgcggc 5640
cgtcgtaatt gcgggtagct caccgctgtg gagccgacag ctattcgtcg aggggcgctg 5700
gctgtccgtg gggctactca gcgttggggt ggccgggttc tgcgcgcagg cgaccctgct 5760
gggcgcgctg gccggcgtcg accggtggac acagtacggg tcactgatgg tgaccgacgc 5820
ggtcatccgg ttggcggtcg ccgcggcagc ggttgtgatc ggatggggtc tggccgggta 5880
cttgtgggcc gccaccgcgg gagcggtggc gtggctgctc atgctgatgg cctcgcccac 5940
cgcgcgcagc gcggccagcc tgctgacgcc cgggggaatc gccacgttcg tgcgcggtgc 6000
cgctcattcg ataaccgccg cgggtgccag cgcgattctg gtaatgggtt tcccagtgtt 6060
gctcaaagtg acctccgacc agttaggggc aaagggcgga gcggtcatcc tggctgtgac 6120
cttgacgcgt gcgccgcttc tggtcccact gagcgcgatg caaggcaacc tgatcgcgca 6180
tttcgtcgac cggcgcaccc aacggcttcg ggcgctgatc gcaccggcgc tggtcgtcgg 6240
cggcatcggt gcggtcggga tgttggccgc agggcttacc ggtccctggt tgctgcgtgt 6300
tggattcggc cccgactacc aaactggcgg ggcgttgctg gcctggttga cggcagcggc 6360
ggtagctatc gccatgctga cgctgaccgg cgccgccgcg gtcgcggccg cactgcaccg 6420
ggcgtatttg ctgggctggg tcagcgcgac ggtggcgtcg acgctgttgc tgctgctgcc 6480
gatgccgctg gagacgcgca ccgtgatcgc gctgttgttc ggtccaacgg tgggaatcgc 6540
catccatgtg gccgcgttgg cgcggcgacc cgactgattt gtgccccagg tcgacaaatc 6600
acgccgtctc gtcagtgagc actccgtcct cgggtccgat ccttccagga gacgttgcaa 6660
cctgatttgg ctcaaattgg tgcgcaccga gggtcgggca catcgtaggg tcgcaacagt 6720
cacatgtgtc actgcaccgg gcgacacccg atgtcccggc tctcagcgac agctgtctga 6780
cctgtggttt tgttcccaag ttggtcgtgg ctgtgcggga ttggaggtgg cgtgggggtc 6840
gcgtcgtatg gattctcctc ctcggttccg cgcgaaacgg ccgcaggcgc aatggtcacc 6900
aacttggccg cggtggagtc tagcctcaca ttttcctggt cgcccccgac aaccaggagg 6960
tcgctgcaga acgggcgttc cctacccaca tctactatga agcgacagcg gcgccccgct 7020
gtgatggctg agcatgaccg acagaggcgg gaagacagtg aagcgagcgc tcatcaccgg 7080
aatcaccggc caggacggct cgtatctcgc cgaactgctg ctggccaagg ggtatgaggt 7140
tcacgggctc atccggcgcg cttcgacgtt caacacctcg cggatcgatc acctctacgt 7200
cgacccgcac caaccgggcg cgcggctgtt tctgcactat ggtgacctga tcgacggaac 7260
ccggttggtg accctgctga gcaccatcga acccgacgag gtgtacaacc tggcggcgca 7320
gtcacacgtg cgggtgagct tcgacgaacc cgtgcacacc ggtgacacca ccggcatggg 7380
atccatgcga ctgctggaag ccgttcggct ctctcgggtg cactgccgct tctatcaggc 7440
gtcctcgtcg gagatgttcg gcgcctcgcc gccaccgcag aacgagctga cgccgttcta 7500
cccgcggtca ccgtatggcg ccgccaaggt ctattcgtac tgggcgaccc gcaattatcg 7560
cgaagcgtac ggattgttcg ccgttaacgg catcttgttc aatcacgaat caccgcggcg 7620
cggtgagacg ttcgtgaccc gaaagatcac cagggccgtg gcacgcatca aggccggtat 7680
ccagtccgag gtctatatgg gcaatctgga tgcggtccgc gactgggggt acgcgcccga 7740
atacgtcgaa ggcatgtggc ggatgctgca gaccgacgag cccgacgact tcgttttggc 7800
gaccgggcgc ggtttcaccg tgcgtgagtt cgcgcgggcc gcgttcgagc atgccggttt 7860
ggactggcag cagtacgtga aattcgacca acgctatctg cggcccaccg aggtggattc 7920
gctgatcggc gacgcgacca aggctgccga attgctgggc tggagggctt cggtgcacac 7980
tgacgagttg gctcggatca tggtcgacgc ggacatggcg gcgctggagt gcgaaggcaa 8040
gccgtggatc gacaagccga tgatcgccgg ccggacatga acgcgcacac ctcggtcggc 8100
ccgcttgacc gcgcggcccg ggtctacatc gccgggcatc gcggcctggt cgggtccgcg 8160
ctgctacgca cgtttgcggg cgcggggttc accaacctgc tggtgcggtc acgcgccgag 8220
cttgatctga cggatcgggc cgcgacgttc gacttcgttc tcgagtcgag gccgcaggtc 8280
gtcatcgacg cggcggcccg ggtcggcggc atcctggcca acgacaccta cccggccgat 8340
ttcctgtcgg aaaacctcca gatccaggtc aacctgctgg atgccgccgt ggcggcgcgg 8400
gtgccgcggc tgctgttcct gggctcgtcg tgcatctacc cgaaactcgc cccgcagccg 8460
atcccggaga gcgcgctgct caccggtccg ttggagccga ccaacgacgc gtacgcgatc 8520
gccaaaatcg ccggcatcct tgcggtccag gcggtgcgcc gccaacatgg cctgccgtgg 8580
atctcggcga tgcccaccaa cctgtacggg ccaggcgaca acttttcgcc gtccggctcg 8640
catctgctgc cggcactcat ccgccgctat gacgaggcca aagccagtgg cgcgcccaac 8700
gtgaccaact ggggcaccgg cacgccccga cgggagttgc tgcacgtcga cgacctggcg 8760
agcgcatgcc tgtatctgct ggaacatttc gacgggccga cccatgtcaa cgtgggaacc 8820
ggcatcgacc acaccatcgg cgagatcgcc gagatggtcg cctcggcggt aggctatagc 8880
ggcgaaaccc gctgggatcc aagcaaaccg gacggaacac cacgcaaact gctggatgtt 8940
tcggtgctac gggaggcggg atggcggcct tcgatcgcgc tgcgcgacgg catcgaggcg 9000
acggtggcgt ggtatcgcga gcacgcggga acggttcggc aatgaggctg gcccgtcgcg 9060
ctcggaacat cttgcgtcgc aacggcatcg aggtgtcgcg ctactttgcc gaactggact 9120
gggaacgcaa tttcttgcgc caactgcaat cgcatcgggt cagtgccgtg ctcgatgtcg 9180
gggccaattc ggggcagtac gccaggggtc tgcgcggcgc gggcttcgcg ggccgcatcg 9240
tctcgttcga gccgctgccc gggccctttg ccgtcttgca gcgcagcgcc tccacggacc 9300
cgttgtggga atgccggcgc tgtgcgctgg gcgatgtcga tggaaccatc tcgatcaacg 9360
tcgccggcaa cgagggcgcc agcagttccg tcttgccgat gttgaaacga catcaggacg 9420
cctttccacc agccaactac gtgggcgccc aacgggtgcc gatacatcga ctcgattccg 9480
tggctgcaga cgttctgcgg cccaacgata ttgcgttctt gaagatcgac gttcaaggat 9540
tcgagaagca ggtgatcgcg ggtggcgatt caacggtgca cgaccgatgc gtcggcatgc 9600
agctcgagct gtctttccag ccgttgtacg agggtggcat gctcatccgc gaggcgctcg 9660
atctcgtgga ttcgttgggc tttacgctct cgggattgca acccggtttc accgaccccc 9720
gcaacggtcg aatgctgcag gccgatggca tcttcttccg gggcagcgat tgacgcgccg 9780
gcgcgtcaat ctatttcgac attcgcgtga agacgttttc ccagaatcga ctgttgtagg 9840
cgtagaactc ccggccgcgt aggtaggcat gtgatattcg ccttcccccg aacgggtagc 9900
ggcgatgaag gtcgcccatg cggcgcagat caccgaagac cgcgcttggt tcccggtgcg 9960
agccgacgcc cgtggtgtcg aactcgcaca gcacacaccg aatcgtgacc ggctcgcata 10020
ccagcgcggc ccgcaatatg aattcctggt cggcggcgat cccgaaatca aggtcgtagc 10080
caccgatctt ggccaccagc gatgatccga agaacgatgc ttgatgcgga acaacctgct 10140
tgccggccag gaatttgcgc aggctgaaag gtatcgggcc gcgcacccga tcgagcccga 10200
cgagacgatc catcccgaag ccccacaatt cggacaccgg tcccttgccg gatagcgcct 10260
ccacggcctg ggctaccacg tcgggcccgg aaaaacgatc ggcggagtgc aagaaccaca 10320
acagatcacc cgatgcgtgc gcgatgccct ggttcatcgc gtcgtaccgc ccgccgtcgg 10380
gctcggactg ccaatacgcg aagcctggtt cacacccgga caggtatgcc accacgtcgt 10440
cgccgctgcc accgtcgatt acgatgtgct cgatgcgtcc ccggtagcgt tgcgcccgca 10500
cacttttcac cgtgcgctgc aacccgtcga ggtcgttgaa cgagatcgtt atcaccgaga 10560
cggtcggagc agacgtcacc gagttcccct aggttgctgg cggcgattgt ggatcaccgg 10620
gtcttgatac cgatgaaggt gcctcgaaga ttcgccgcat aggaacctcc gagcaacgac 10680
tcggcgatgc ttggttccaa gttgtcgtac tcctccatca ccaggtcgac gccgacgtct 10740
ttgatggcct gaagtaggtg ctcgcgttga atccagaatg accggcgatt gtcccaggac 10800
gcccattttg cggtgtcgcg ctggccaaac gagcggtcgt cggaaaactc ggtaaaccac 10860
ctaccgggaa gtccctcatg ttcggtgggc gccgagagca tgaacttcac cggcgccggc 10920
cgccgcagca accgatcggt caattgtcgt gccgtcgtgg gcaaccggag ccatttatcg 10980
ctccggttga tgatcgagaa gtgcgtctgg agaatcagca gcttgttcgt taccgacgag 11040
agggtttcca ggtattgctt cggattctcc aggtggtaga agaggccgca gcagaagacg 11100
gtatcgaaga gcccgtggtt ggcgatgttg agggcgttgt cgtggacgaa ccggagattc 11160
ggcaggttgg tcttcgattt gatgtagttg caggccgcca tgttcagctc gcgaacctcg 11220
atcccgagga cctgaaatcc catgcgcgcg aacccgaccg cgtacccgcc ttccaagcag 11280
ccgacatcgg ccaggcgtag gtggctcttg tccccgggaa agacggtttc cagaatcccg 11340
cgcgccgaga tgaaccagga cgattcgtct aacgtgcgcg aggactccgg tatcgtcaag 11400
gttccgtcgt cgaggcgaac gttgtgggcg gtgaattgta ccgcgccggc cgaatgttcc 11460
tgtgccatca cttggttagc cccttcggct ggtcctgggt ttgtcgacat ggtcaggctc 11520
gacagccgcg tcggagccgg gagggccaca catccacgag ccccctgcgg ctcggcgtcg 11580
cggcggcgag cttgcgccac tgggtcttga gccgccgcgc gggtgtcgcc ccgcggtgct 11640
gcagcgccag catggcgatc cggggatggc gcgcgatggt ttcctgcagc gcggcgcgcc 11700
cctccgggcc tggaacgttg gcgatctggc gaaggatcca gtcggccatg acggcgatga 11760
gctcctcgcg cgcggggtct cccgggaaca ggtcgagcat cgcgtcaaac gtcgccgcat 11820
gccccggacc ctgcgtcaac cagaactttg gcgggtccac cacctggttg tgccacatgc 11880
cttgggcgtg gcggcgatac acggccatgg tgtcgggcaa catggcgatg tcgccatgca 11940
ccgcgtgccg gacgtgcaga taccagtcca ggggcatgac gtcggcagga atgtcgtcgt 12000
agcgctcgag gcgacggtac acggccgagt tggtctggat gaagttcatc aagatcaacg 12060
catccaggct caagttgccc cgcacccgaa ccggggggaa cttcgagtcc ttggcatggc 12120
cgtcctccca tatcactcgg acgggatgga agcacaccgt cgtcttgggg tgccggtcga 12180
ggaatgcgac ctgtttgctt agcttcagcg gatcgatcca gtagtcgtcc gcctcgcaca 12240
acgcgacgta ctcgccgcga gcggccgaca gggcgccggt caggttccca ttgaggccga 12300
ggttttcggt cctgaagatc ggccggaaca cgtgcgggta ccgctcggcg tactcacgga 12360
tgatcgccgg ggtggcatcg gtcgacgcgt cgtcggcgac gatgatctcc accgggaagt 12420
cggtttgctg gtcgagaaag ctgtcgaagg cctgacgggc gtagcccgcc tggttgtgag 12480
tggtcgagac gatgctcacc ttggggcaaa gctggggact caccgtcggc ccttttcctg 12540
cgcggccgca agggtattgc gatggcgaac gtgaatcgcc tgtgcccgcc ggccgtcggc 12600
cgtcgtggcc tggtggtcgg cggacgtacg gcacacgctg gcgaagtata gcgagggtgc 12660
actgacgttg ggctcgaacc gcgtggcgcg cggtgtgggc gcaccgtctc gagtcggtgc 12720
tggttggctc gc 12732




2


289


DNA


Mycobacterium tuberculosis



2
atactcaagc ttgccgcaat cgaaaccaac ctgtttgtgc cgcaagaaat tacgccgtgg 60
cccggcgccg atcaagaaac gccccggcgc gcggcggtgt cgtcgtatgg catgacgggc 120
accaatgtgc acgccattgt cgagcaggca ccggtgccag cccccgaatc cggtgcacca 180
ggcgacaccc cggccacacc cggtatcgac ggcgcgctgc tgttcgcgct gtcggccagc 240
tcgcaggacg cgctgcggca aaccgccgcg cggctggccg attgggtct 289




3


278


DNA


Mycobacterium tuberculosis



3
ttggcgggtt ggccacacac ccgccggtga cggcgacgat gctgggctgg ttgcggccct 60
gcgccaccgc ggcttgcatg ctggttggct gtcttgggac gatcccgaaa tagtccacgc 120
ggatctggtg attttgcggg ctacccgcga ttaccccgcg cggctcgacg agtttttggc 180
ctggactacc cgcgtggcca atctgctgaa ctcgcggccg gtggtggcct ggaatgtcca 240
cgccgttcac ctacgtgacc ttgatgggat ccgggggt 278




4


1280


DNA


Mycobacterium tuberculosis



4
ccgacccaga cactgaccgg gcgaccgctg atcggcaacg gcacccccgg ggcggtcggc 60
agcggggcca ccggggcccc cggtgggtgg ctgctcggcg acggcggggc cggcgggtcc 120
ggcgcggcgg gctcgggcgc gcccggcggg gcgggcgggg ctgccgggct gtggggtacc 180
ggcggggccg gcgggatcgg cggagccagc accgtactcg gcggcaccgg cgggggaggc 240
ggggtcggtg ggctgtgggg cgccggtggg gccggcgggg ccggtggaac cggccttgtt 300
ggtggcgacg gcggggccgg tggggccggc gggaccggcg gactgctggc cgggctgatc 360
ggtgccggcg gaggtcacgg cgggaccggc gggctcagca ctaatggcga cggcggggtt 420
ggcggggccg gcgggaatgc cggaatgctc gccgggccgg gcggcgccgg cggagccggc 480
ggtgacggcg aaaacctgga caccggtggg gacggcgggg ccggcggtag cgcagggctg 540
ctgttcggca gcggcggcgc cggcggcgcc ggcggatttg gtttcctcgg tggggacggc 600
ggggccggtg gcaacgccgg gctgctgttg tccagcggcg gggccggcgg gttcggcggg 660
ttcggcaccg ccggtggggt cggtggggcc ggcggcaatg ccggctggct gggcttcggc 720
ggggccgggg gcatcggcgg aatcggcggt aacgctaacg ggggcgccgg tgggaacggc 780
ggcaccggcg gtcagttatg gggtagcggc ggcgccggcg tcgaaggcgg cgcagcctta 840
agcgtcggcg acaccggcgg ggccggtggc gtcggcggca gcgccgggct gatcggcacc 900
ggcggcaacg gcggcaacgg cggcaccggc gccaacgccg gcagccccgg aaccggcggc 960
gccggcgggt tgctgctggg ccaaaacggg ctcaacgggt tgccgtagcc gggcggcacg 1020
gcatggcttc cgggcgtcaa ccactcgccg gtgatgcaga tcggctgcgg agcgggccgc 1080
caaaatgggg gccgccgcgc caggtatctc ggcgaagatc cccggcgctc gagcgctttg 1140
tcagaggccc gtcgcgggtc gtcgtgacga cggctatccg ggcggtgcgg gtttcgcggc 1200
gcgccctgtg cccggcaccg ccgcccgttt gtcggcaacg ccgccgcgac ccgtgagccg 1260
tccagcagct ggcgcctgcg 1280




5


127


DNA


Mycobacterium tuberculosis



5
gggcatcggc ggaatcggcg gtaacgctaa cgggggcgcc ggtgggaacg gcggcaccgg 60
cggtcagtta tggggtagcg gcggcgccgg cgtcgaaggc ggcgcagcct taagcgtcgg 120
cgacacc 127




6


434


DNA


Mycobacterium tuberculosis



6
aatactcaag cttgcccagc cgtcgatgac aagaaatatg tccgcaaaag actcagcggc 60
cgactttgct cgcagctggc ggtaccgcgc caccgattct atgccgtggt cgcggaaaaa 120
tgcctcccga aatcgcacgg ccgactccag ttcggcgagc atccgcgatg ccagctgcgg 180
ctgcgccctg ccggccacgg cacccacatg cggcagttcg tccacctggg ccagcgcccc 240
gccgccgaat tccaaacaat agaactgcac ccggcccgca tcgtgggtaa cagccaacgc 300
catgatcagc gtccgcagcg cggttgactt gcccgtttgc ggtgcaccta cgaacgcgac 360
attgcctgcg gccccggaca agtcgatcgt gcgcggcacc cgtgactgct ctaacgggcg 420
attgaaattc cgat 434




7


332


DNA


Mycobacterium tuberculosis



7
ccacccgtgt aatttgggat gggcaaaaag gcgaagcacc gcgtggccac gaacgccggg 60
agggacaatc tcgggcggtt agggcttctc gcgggaaggc ccgaacgtac ggcgtttcaa 120
cacctcgcgt cgccctccga ccgcgaacat tcggggatgg cagcaacctg ctggcaccct 180
ggccgggcga tgatctgcag cgtcgccgcg ggtagtcgcc gcccgggcgg ctacactctg 240
aaacgcgatg accatcgatg tgtggatgca gcatcccgac gcaacggttc ctacaccgcg 300
atatgttcgc ctcgctgccc cggtggaccg gt 332




8


354


DNA


Mycobacterium tuberculosis



8
aatactcaag ctttccgccg atacccgcca tgtcgcgcac atccaggact tctgggggga 60
tccgctgaca gcggcgggat cccaaagtgc ggatgatcgg gccgcctacg tcgtggtgta 120
cctcgtcggt aacaacgaaa ccgaagcgta tgactcggtc cacgcggtgc ggcacatggt 180
ggacaccaca ccgccaccgc acggggtgaa ggcctatgtc accggtccgg cagcactcaa 240
tgccgaccag gccgagggcg gagacaaaag tatcgctaag gtcaccgcga tcaccaacat 300
ggtgatcgca gcaatgttgc tagtgatcta tcgctccgta attaccgcgg ttct 354




9


353


DNA


Mycobacterium tuberculosis



9
gtgccgttcc aacccgaatt ggctttcggc gccatcggtg aggacggcgt gcgggtgctc 60
aacgacgacg tcgtccgcgg gacacacctc gatgctgccg ccatggacgc ggtcgaacgc 120
aagcagctga tcgagctaca acgccgcgcg gaacgcttcc gccgcgggcg tgaccgcatc 180
ccgttgaccg ggcggatcgc ggtgatcgtc gatgacggca tcgccaccgg agcgacggcc 240
aaggcggcgt gccaggtcgc ccgggcgcac ggtgcggaca aggtggtgct ggcggtcccg 300
atcggcccag acgacatcgt ggcgagattc gccgggtacg ccgatgaggt ggt 353




10


279


DNA


Mycobacterium tuberculosis



10
aatactcaag ctttcggcgg aaacggacac attgcgaata ttgatgacaa aataaaaatc 60
attgatggtt tgagtcacca ggccgatcaa gccttcgccg agccaaattc caatcaagag 120
gcccaagccc gtaccaatca gcccggcaac gagggattcc gtcattatca gccaaaataa 180
ctgctctcgg gttacaccca aacagcgcaa tatggcgaaa aacggtcgcc gttgcacgac 240
attaaatgtc acggtattgt agattaaaaa gatacccac 279




11


376


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






11
tgctcccgaa acctgggggt gtgcctgctc tgtatgcacg gcatacggac atccttcccc 60
tgagacccgc ggtcgaacca gccacgtgtc catcatagng ggtcaacccc ggccaagggc 120
gacggcacgc caagttcgcc gaccgttaac ctagtgctgt tagcttcatt tgctgcgatc 180
aaaacagctg gtcggccgtt aggaactgaa ttgaaactca accgatttgg tgccgccgta 240
ggtgtcctgg ctgcgggtgc gctggtgttg tccgcgtgtg gtaacgacga caatgtgacc 300
gggggaggtg caaccactgg ccaggcgtcg gcaaaggtcg attgcggggg gaagaagaca 360
ctcaaagcca gtgggt 376




12


393


DNA


Mycobacterium tuberculosis



12
atactcaagc tttgccgacg agcgggcgat gttgatgacg ggaaacccca gcgcacaacc 60
gacgattttg gcgtagccgg cggacgtctg ctcgattccg atcacgtcgg cgctcgcatc 120
gagcatggcg ccggcgacgg ctagcagcga tccgccgtcg tcgaggagca cgacacgagc 180
cgtacgcccg gccgtaagcc gcgcccagga ttcggcgaaa aaccgttcta cgtggcgggt 240
gtactgggtg tcgaatgatt cgtggggtgc gtaggcgtcg ctgcaatcgt cgacatagat 300
gccgtcgggc cgcatcgcgt cgacaactcc gggtgagtgg aatagcactt gccgatcacc 360
gcgacgttgc gcggatgagg ccgaacccga ata 393




13


272


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






13
tcctatgtcc ctgccgagca ngtgatcgaa cgcggtgaca gatttgtcta tcctggacct 60
gacggtgagg tcgaagtttt ccaggaattc ggcaaaatcg gtaagagcct gaagaattcg 120
gtatcgccgg acgaaatctg cgacgcatac gggggcatat acgcttcggg tttacgagat 180
gtcgatgggg ccgctggagg cttcacgtcc atgggccaca aaggatgttg tcggcgcgta 240
ccgttttctg cagcgggtgt ggcgcttggt cg 272




14


286


DNA


Mycobacterium tuberculosis



14
atactcaagc ttgattccgc cgaaaccgac cgtgagcacc ccgccagcca ccacgctcgg 60
gtcgggcgcc gggcccgggc cgccaggctg ctccgctcgg tgatggcacg ccaccgcgac 120
accacccggc tgcgctacgt ctaaccattc caggcggagc tacatcagct cggccgccca 180
gtgttcgggc cctctttcca ggtcgaagtc tataccgata tgcgcatccg cagccgccac 240
cctggagaac agaacgatgc cctactaatg cttgtctggc ggggcc 286




15


357


DNA


Mycobacterium tuberculosis



15
ggtacgcttc ggtcgcagtc tgcgagtgat gcatgacgac cgggacctcg tcggcatctt 60
ccatagcccg ccacaccttc agttgctcac cggaatccaa ccggtagaag gtcggcgagc 120
gctcggcatt ggtcatcggg atatgccgct cgggacggtc agagccctcg ggtccggcca 180
gcactccgca ggcttcgtcg gggtggtcgc gacgcgcatg ggccaccatc gcattcacca 240
ggtctgcgcg aatcaccagc acgtagacgg ttcctttcct aagcaacacc gaagtttcag 300
gacccgaatg ctccgggaaa catgtcacgg taggtcggta ttccggctac cggctga 357




16


83


DNA


Mycobacterium tuberculosis



16
ggcgtcaacg gtgtcggaac ccgcgtcaag caattggtag gcctgcagtc tgtgaatcag 60
gccgacgctg tggccgccgc ggc 83




17


383


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






17
ggctngcgta cccggtaccg gccgcgggcc taccacgtgc cggaactgga agcgcagtaa 60
gccctcaacg cgccaccgct ttggcccgcg cgcccggcgt aggcgcatcg gcggtggccg 120
tggggcggcg cactgcgacc tcaccagcgg ctttcgagct ttgttcgatc aaccggccag 180
catggtcgan gatgcattcg agaccatatt cgaaattggt ttcatcgggg gccccgatcc 240
gatgccccct cccagttgcg tgagcaanca gcggagtcnt cgcgggatcg atggccacgg 300
ggtgttcaat ggcggatggt ccgctgcccg ccgactggct cttgcgggag aaccgatcta 360
gcaccaccga tccgcgcacg tng 383




18


603


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






18
cgtaatntcg cgcacancca ngacttctgg ggggatcngc tgacagtggt nggatcccaa 60
attgcggatg atcgggccgc cnacgtcgtt gtgtacctcn tcngtcacaa cnaanccgaa 120
ncgtatgact cggtccacgc ggtgcggcac atggtggaca ccacaccgcc accgcncggg 180
gtgaaggcct atgtcaccgg tccggcaaca ctcaatgccg accaggccga ngccggacac 240
nanagtatcn ctaacgtcac cgcgatcacg agcatggtga tcgnncaatg ttnctantga 300
tctatcgctc cgtaattacc gcggttctcg tcttgatcat ggtcgcancg aactccggcg 360
caatccgcgg attcatcgnc ttgctcgccg atcacatatt ttcagccttt cacattgcaa 420
cnaacctgct cgtctcatgg ngatgcggcg acacggacta ccgatatcat gctcgccgtt 480
acacaatcnc gccacgccgc gaagacngga aacgcttcta cacaatnttc ncgggacgcc 540
actnaacttg gttcnggttt gacattgccg cgcatgtntg cccagctttg ccggctcccc 600
tta 603




19


190


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






19
tgaatttccc gatcccacaa tctcggttca gatacaggtc gccatacccc ttacttcggc 60
aacgctgggc ggattggccc tgcngctgca gcanaccatc gacgccatcg aattgccggc 120
aatctcgttc agccaatcca tacccatcga cattccgccg atcgacatcc cggccttcnc 180
cctttaacgg 190




20


506


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






20
aacagctatg accatgntta cgccaagcta tttaggtaac actatanaat actcaagctt 60
ttacggtgat cgcgcatcac ctggttcatg aactggaagc agcgcancgc ttccttttcg 120
gccgcaacat gagccagcct ctcgtccgcg gtcnggtgca ggtgctcggg cagctcggcc 180
gcgacagccg cctgaccctg aaaccagctt ccatatcccg cgacnaacna cnccagtccg 240
ctacgtaacc cctccgcgac tgtccatgga caacagcgcg ttctccaccg accgggcccg 300
ggtgtggggt gtttcggcga ccggcagcca ggtggtccac actgccgacg ggcgccgcga 360
gccgttcacc gaccaagccg ccgaacaagt ccgcccgatc gcatactcca accggttgcg 420
gtactgcagg tcagctggcg tacctcctcn tcncgctcgg cgaagtcttg ctccancacg 480
tcgcagaacg gcaaggaaca cgttca 506




21


388


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






21
gaccgnncca tgtttccaca atgtggtgcc agtncggngg ctacgtgcca tcnanacact 60
ggcgcaggct atcgcacccg ttatcngcta cgaacaaatc ncggtatgcg ttctttanca 120
tgagtcggcg accgncgatc atggtcgaca cccacgacng aaatacgcag atcgccntcn 180
agcntgtgtg ccgcggatta tcangactga cctcctggct gaccggnntg tntggtcgcg 240
atgcctggcg cccggccggc gtgntcgtgg tcggctcgga tagcgaagtc agctaattct 300
cgtggcagct cgaaagggtc ctgccggtgc cggtctttgc gcaaaccatg cncatgttac 360
ggtccctcgg gtgcggcctg gcggcggc 388




22


138


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






22
gggatgggcg ggcccgctaa actcttcgtg ttccactaac tccgggaggg ncaatctcgg 60
gccgttatgg ctcacgtcgc gtcgccctcc gaccgcgaac attcggagtt ggcagcaacc 120
tggtagcacc ctggccgg 138




23


142


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






23
nccgtcgttg acaagtaaat atgtccgcaa aagtctcagc ggccgacttt gctcgcaggt 60
ggcggtaccg cgccaccgag tcgatgccgt ggtcgcggaa gaatgcctcc cgaaatcgca 120
cggccttccc nntttaaacg ga 142




24


441


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






24
tttaggtgac actatagaat actcaagctt ttggtctagc cggccgagca cgatacgggt 60
gtcattggcc accggcggcg gctgtccggg aaatggcggg tccccggtgg ttttgctgat 120
gagtgctgaa ccgtantcga agtgggcggc gtcagactcc acccanccag caggcagcgc 180
gaagctgaat cctccaaccg ggttgtcnat ccggacaagt tggggtgcgt ttggggcaat 240
gacaggtggc ngcggtgcgt tcgggtccgc cggcggaagt gctgcgttgg gatcncccgc 300
tgggcattcg gcntttttgc ggcggccggt ggtngggggg caacaggtnt cccngtgcgg 360
gtggcgctca acggtcnacg gcgcaagccg ccgttgttgg taccnggggc gctggctccg 420
gatcgcgttg gcggtcnccg g 441




25


453


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






25
ctacaccatc gaatacgacg gcgtcgccna ctttccgcgg tacccgctca actttgtgtc 60
gaccctcaac gccattgccg gcacctacta cgtgcactcc aactacttca tcctgacgcc 120
ggaacaaatt gacgcagcgg ttccgctgac caatacggtc ggtcccacga tgacccagta 180
ctacatcatt cgcacggana acctgccgct gctagagcca ctgcgatcgg tgccgatcgt 240
ggggaaccca ctggcgaacc tggttcaacc aaacttgaan gtgattgtta acctgggcta 300
cngcgacccg gcctatggtt attcnacctc nccgcccaat gttgcgactc cgttcgggtt 360
gttcccanaa gtcnncccgg tcgtcatcgc cgaanctctc ntcccgggac ccacagggaa 420
tcngcnattt cncctacaaa tcanccacct cca 453




26


228


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






26
gcatgatcgg ccacctttcg ggccgcccgg catacggcgg cgtaccgatc tccgcgtcat 60
acacccgcgg gtaatcgccg acggtgccgg ttcgcgagcc gaaggtgacg actctgattg 120
aatcgagttc caggtccagc gggtggcgca ccaacggcgc gagctcaacg acgtcaatcn 180
cgttgtcgct ttctacggtc accgaccctg gtgaccgtag ttcncccg 228




27


357


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






27
gacactatag aatactcaag cttgccaacc gccagcctgc atccggcggc gancactgct 60
ccgccgacca gtacgaacca acctgcggtg cccaggccat tgacgatgtg ctggtcggcg 120
cccgcgagtc cgcgcaccat caacgccgcg ggcaccacca nggcggcccc accctgcacg 180
gcgacgatca ttccggcgcc gctcacggcg ggcggggctc gaacangcac agcatcaacg 240
tngtcacccg gccgtgaccg gcccgcatcg tcacaccacc caagcccatt gccgtcctcc 300
tcaacngggc gacccggccc gcatcgtcac acggnctaag gccattgccg tcctcct 357




28


384


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






28
tcggcgccat cggcaccttc gaggacctgt atttcgacgc cgtggccnac ctgaggttgg 60
cggtggacna agtgtgcacc cggttgattc gctcggcctt gccggatgcc acccngcgcc 120
tggtggtcga tccgcnaana gacaanttgt ggtggangct tctgctgcct gcgacaccca 180
cnacgtggtg gcaccgggca gctttagctg gcatgtcctg accgcgctgg ccgacnactc 240
cagacnttcc acnaanggtc gccnncccaa tgtnccgnan tgtctccggn tccctttacc 300
ncccaatggg cngnttccac nggttacggg ccccntnccg gcgggtctnc ctcccaanct 360
accaaatacg cccgacnttc cgga 384




29


266


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






29
atactcaagc ttttatggtg atcgcgcatc acctggttca tgaactggaa gcagcgcagc 60
gcttcctttt cggccgcaac atgagccagc ctctcgtcgg cggtcgggtg caggtgctcg 120
ggcagctcgg ccgcgaacag cccggcttga accctgaaaa ccngctttcc atatcccgcg 180
acgaaagaac gccagttccg ctacttaacc cctccgcgaa ccgtccatgg acaacagcgc 240
gttctccacc aaccgggccc gggtgt 266




30


423


DNA


Mycobacterium tuberculosis



30
tcggctcagg ccgcgctgct ggtagagtcg ctgaccggtg caggtttcga caatgtggtg 60
ccggttcggc ggctacgtgc catcgagaca ctggcgcagg ctatcgcacc cgttatcggc 120
tacgaagcaa atcgcggtat gcgttcttga gcatgagtcg gcgaccgtcg tcatggtcga 180
cacccacgac ggaaagacgc agatcgccgt caagcatgtg tgccgcggat tatcaggact 240
gacctcctgg ctgaccggca tgtttggtcg cgatgcctgg cgcccggccg gcgtggtcgt 300
ggtcggctcg gatagcgagg tcagcgaatt ctcgtggcag ctcgaaaggg tcctgccggt 360
gccggtcttt gcgcaaacaa tagcgcaggt tacggtcgcg cggggtgcgg cctggcggcg 420
gcc 423




31


455


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






31
caagctattt aggtgacact atagaatact caagcttcgc gtctacgccg gcccggagca 60
tccgcacagc gctcagcagc cggttccgta cganctcaag caggtggcgc aatgaccgaa 120
accaccccag ccccgcaaac cccggcggcc ccggccgggc ccgcacaatc gttcgtgttg 180
gagcggccca tccanaccgt tgggcgccgt aaggangccg tggtacgaat gcggctggtg 240
cccggcaccg gcaagttcga cctcaacggc cgcagcttgg angactactt cccaaacaag 300
gtgcaccagc agttgatcaa ggcacccctg gtcaccgtgg atcgggtgga aagtttcgac 360
atctttgccc acctgggcgg cggcggccgt ccggtcaggc cgggcctgcc ctgggtatcg 420
cccgggcatt gattctggta tccccngaag aaccg 455




32


371


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






32
cggttggcca ccgcttctgc ggtgccgccg ccgtcgacaa tgaccgtgtc gtccttgctg 60
accaccacgc gtcgggccga gcccagcacc tccaagccca cctcgcgcag caccatgccg 120
gcgtcggggt tgaccacctg gccacccgtc accaccgcca ggtcctcaag gaaacgcctt 180
acggcggtca ccgaagtacg gccccttgac cgcgaccgct ttcaacgtct tgcgaatcgc 240
gttgacgacc agcgtcgcca acgcttcgcc ctccacgtct tcagccacga tcagtagtgg 300
cttacccgtt cctgcaacct tttccagcaa tggcaacaga tcgggaagcg anctgatctt 360
gtcttggtgc n 371




33


320


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






33
ccaagctatt taggtgacac tatagaatac tcaagctttt ggctgggtcg ccttcgaatt 60
cngcgtgcac cgctatgggt tgcancagcg gctggcgccg cacaccccac tggcccgggt 120
gttttcgccc cgaacccgga tcatggtgag cgaaaaggan attcncctgt tcgatgctgg 180
gattcgccac gccaaggcat ctancgatta ctctccncgg ggtgggaaaa gtgcccaatc 240
cccctccctc caactttccn aacaatcatt ccggttccnc cntccggttg gnggtaaccn 300
nccaataaaa cccctgcccg 320




34


383


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






34
gcccgcncat ggccaatccc cgaagacatc attggccagt ggccgggcgc taacaggttc 60
cagcccccca ccantgccgc tcgaacatgc ggtgcaaccc attcgcaggc cggcagggaa 120
agcaccgcgg aagccgcaaa gggctgcagt tccgcgccca ataatgtcgt ccgcaaccag 180
atgcgctcna aaaccncncc ggcagtcagc gcacccgacg cgangtcgaa agacgtcntc 240
agcgcgccca catggggtgc caatcggcac ggcaggtatg ccgcgcgcaa cccgagcgcg 300
tggtgcatgc ccacggtccg cangangcgc ancacccgcc aatgccgaan cccacgaaac 360
atcgggcgca tccaccttca acc 383




35


275


DNA


Mycobacterium tuberculosis



35
atactcaagc ttgcccagcc gtcgatgaca agaaatatgt ccgcaaaaga ctcagcggcc 60
gactttgctc gcagctggcg gtaccgcgcc accgagtcga tgccgtggtc gcggaagaat 120
gcctcccgaa ttcgcacggc caattccatt ccgggaagca tccgcaatgc cagctgcggt 180
tgccccctgc cggccacggc acccacttgc ggcattgcgt ccacctgggc cagcgccccg 240
ccgccaaatt ccaaacaata aaaattgcac ccggc 275




36


322


DNA


Mycobacterium tuberculosis



36
ccacccgtgt attttgggat gggcaaaaag gcgaagcacc gcgtggccac gaacgccggg 60
agggacaatc tcgggcggct agggcttctc gcgggaaggc ccgaacgtac ggcgtttcaa 120
cacgtcgcgt cgccctccga ccgcgaacat tcggggatgg cagcaacctg gtagcaccct 180
ggccgggcga tgatctgcag cgtcgccgcg ggtagtcgcc gcccgggcgg ctacagtctg 240
aaacgcgatg accatcgatg tgtggatgca gcatccgacg caacggttcc tacacggcga 300
tatgttcgcc tccctgcccc gt 322




37


167


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






37
ctgcccatgt ttggggacgc ccgaccagcc gatgctggag gcctacacgg cccttggtgc 60
gctggccacg gcgaccgagc ggctgcaact gggcgcgttg gtgaccggca atacctaccg 120
cagccngacc cctntcncaa naggatnttg ttcgccggac cccnctc 167




38


287


DNA


Mycobacterium tuberculosis



38
ccgactttcc gcggtacccg ctcaactttg tgtcgaccct caacgccatt gccggcacct 60
actacgtgca ctccaactac ttcatcctga cgccggaaca aattgacgca gcggttccgc 120
tgaccaatac ggtcggtccc acgatgaccc agtactacat cattcgcacg gagaacctgc 180
cgctgctaga gccactgcga tcggtgccga tcgtggggaa cccactggcg aacctggttc 240
aaccaaactt gaaggtgatt gttaacctgg gctacgcgac cgccttt 287




39


322


DNA


Mycobacterium tuberculosis



39
atactcaagc tttgtcacac caagtgtttc gaccaggcgc tccatccggc gagtggatac 60
tcccagcagg tagcaggtcg ccaccacgct ggtcagtgcg cgttcagctc gcttgcggcg 120
ctgcagcagc cattcgggga aatacctgcc ctggcgcagc tgggggatcc caacttcaat 180
ggttgcggca cgggtgtcaa attcacggtg gcggtagccg ttgccctaat tggaccgctc 240
atcgctgctt tcgcggtacc ccgccccgca cagggcttcg gcttcagccc ccatcagggc 300
ggcaataaac ttcaagagca cc 322




40


471


DNA


Mycobacterium tuberculosis



40
gaggcagctt cgccggcaat tctactagcg agaagtctgg cccgatacgg atctgaccga 60
agtcgctgcg gtgcagccca ccctcattgg cgatggcgcc gacgatggcg cctggaccga 120
tcttgtgccg cttgccgacg gcgacgcggt aggtggtcaa gtccggtcta cgcttgggcc 180
tttgcggacg gtcccgacgc tggtcgcggt tgcgccgcga aagcggcggg tcgggtgcca 240
tcaggaatgc ctcaccgccg cggcactgca cggccagtgc cgcggcgatg tcagccatcg 300
ggacatcatg ctcgcgttca tactcctcga ccagtcggcg gaacagctcg attcccggac 360
cgcccagcgc attggtgatg gaatcggcga acttggccac ccgctgggtg ttgacatcct 420
cgacggtggg caattgcgcc tcggtaagct ttgccgcgta gccttttcat c 471




41


247


DNA


Mycobacterium tuberculosis



41
atactcaagc ttcactgaca agggacgaat tcgtcggccg cctgttcgac tgggtggtgg 60
ccgagctggt cgccaccact caggccgcgg tcacggcggt accggcgcgg gagcaaactc 120
gcgcgggcat ggccaacttc ttgcggacca tcaccgcaga cgcccgcttc ggacccctgc 180
tgtccaccac acagttggcc aacgcattaa tcacccgcaa gcttgcggaa tccaccgccc 240
tgttcgc 247




42


325


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






42
tccatcaccc gatgtggcng gagcactgcc atgtcgatct caactaccac ctccggccgt 60
ggcggttgcg cgccccgggg ggtccgcgcg aactcgacga ggcggtcgga gaaatcgcca 120
ncaccccgct gaaccgcgac cacccgctgt gggagatgta cttcgttgag gggcttgcca 180
accaccggat cgcggtggtt gccaaaattc accatgcgtt ggctgacggt gttgcctcgg 240
caaacatgat ggcacggggg atggatctgc cgccgggacc ggaggtcggc cgctatgtgc 300
ctgaccccgc tcctaccaag cggca 325




43


221


DNA


Mycobacterium tuberculosis



43
agctttgcag ttgctgagta atgtcggcca acgtcaccac aaccgcgatg aattcaatca 60
tgccgcccag ggcggccaac ccaatggtgg ccgcgagcgg cagctcgatc gcagcgcgga 120
ggttgccggc cgccagttga ttcacgaaca gggtgaggtc ataggcgggc aggatagtga 180
cgaaggcaag acctccatct gccgtcggaa gaagtatcga g 221




44


285


DNA


Mycobacterium tuberculosis



44
agcttcagaa caggcctgtt gtgggcgcac ccggctcgcc gagttctgca cgcaccgcct 60
caagtgcggc ccgcaccgcc ggcatctccc ggtcacgcag ggccgcggcc cgcgccgcag 120
cgacggcgtg ttcgcgcagt tcgccgtcaa tgatgctgac ctgatcggcc acccgggcgt 180
tctcggcgtc gtcgcgttca ctaatcgcgg tgctcagcag cgtctcgaca gccaccaccc 240
gagtggcgac cagctgctcc accacggacc gcagcgatgc ccgtc 285




45


179


DNA


Mycobacterium tuberculosis



45
atactcaagc ttcagttcct ccacgacgcg ttcccaaatg aatttcccga tcccacaatc 60
tcggttcaga tacaggtcgc catacccctt acttcggcaa cgctgggcgg attggccctg 120
ccgctgcacc aaaccatcaa cgccttcaaa ttgccggcaa tctcgttcag ccaatccat 179




46


315


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






46
gctctacgcc gcctacgggt cgaacatgca tcccgagcag atgctcgagc gcgcacccca 60
ctcgccgatg gccggaaccg gctggttacc cgggtggcgg ctgacgttcg gcggcgagga 120
catcngctgg gaaggggcgc ttgccaccgt cgtcnaagac ccaaattcga aggtgttcgt 180
cgtgctctac gacatgaccc cggcggacga gaagaacctt gaccggtggg aaggctccga 240
gttcggtatc caccagaaga tccgatgccg cgtggagcgc atttcctcgg acaccacaac 300
gggatcccgt cctcg 315




47


285


DNA


Mycobacterium tuberculosis



47
atactcaagc ttgccaaaga gacctcgtcc accaagcagg acgcgaccgt cgaggtggcg 60
atccggcttg gcgtcgaccc gcgtaaggca aaccagatgg ttcgcggcac ggtcaacctg 120
cccacaccgg cactggttaa gaactgcccg cgtcgcggtt ttcgcggttg gtgaaaaggc 180
caatgcctgc gtttgccgtg ggggcggatg ttgtcgggag tgacaatctg atcaaaagga 240
ttcagggcgg ttggctggaa ttcaatgccg caatcgcgac accgg 285




48


369


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






48
ccacggcgtg gatcaaggta ccggccggga tgttgcgcaa tggcaggttg ttgcccggct 60
tgatgtcggc gttagcgccg gattccacca catccccttg cgaaagtccg ttgggtgcaa 120
tgatgtagcg cttctcccca tcgagatagt ggagcaacgc aatccgtgcg gtacggttcg 180
ggtcgtactc gatgtgcgcg accttggcgt tgacaccatc tttgtcattg cggcgaaagt 240
cgatcatccg gtaagcgcgc ttatgaccgc cgcctttgtg ccgggtggta atccggccat 300
gcgcgttgcg tccaccgcga cgtgcagcgg gcgcaccagc gacttctccg gggttgaccg 360
ggtnatctc 369




49


461


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






49
gcagcatgac ggcggtagcg aacaccgccg gatgcagcgc aagtagcgtc gatgtgctca 60
cggaatcgcc ccggcaccgc gatctcgang atcaccagtg ccaccccctg cagcgcnaca 120
ccgacgattc cgtacaccgc cacgccgatc aggccctggg ccatctgatt ggagctggcg 180
tanatggcgg cgatggtgac gatggccagc gccacataca ttgtggcggc cagaaccacg 240
gcgttggggc ggcggtcgat gaacactagg cgacgcagat cgcccggggt caacaggttg 300
accatcagaa agcctgcgac tagcacggcg gcgccactag gaagtacaag aangtggcca 360
ccaccccatg caggatcggg gtaaggctga tggtcccgaa atcgactccg gcctaataca 420
tgactctctc ctttgcgtca tcgccttact tgtgcgcgga a 461




50


127


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






50
gggacacacc tcgatgctgc cgcnatggac gcggtcgaac gcaagcagct gatcgagcta 60
caacgccgcg cggaacgctt ccgccgcggg cgtgacgcat cccgttgacc ggccggancn 120
ctctcta 127




51


305


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






51
tgggcgcctc tttcggcctt cccnntttaa acgnagcang acattctggg tatcgagttg 60
tactggatgg tgttggcgat gtcggtgatc ctgctcctgg cggtgggatc cgactacaat 120
ctgctgctga tttcccggtt gaaagaggaa attggggccg gattgaacac cggaattatc 180
cgtgccatgg ctggtaccgg gggagtggtg acggctgccg gcatggtgtt cgccgttacc 240
atgtcgttgt ttgtgttcag cgatttgcga attattggtc agatcggtac caccatcgcc 300
ttccc 305




52


449


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






52
ccgatcggcg ccgcanctgg ttggtgttnc ggatgaatcc gcagcgaaaa tgtagctgcg 60
gtggcgtgtc gtgactcgtn ggcgtcgacg ctcgtggcag ccaccgancg gttggtccag 120
gatctggatg ggcaaagttg tgcggcccgg ccggtgacgg ccgatgagct gaccgaggtc 180
gacagcgccg tgttggctga cttggaaccg acatggagtc gccccggttg gcgtcacctc 240
aagcatttca atggttatgc gaccagtttt tgggttacgc cgtcagacat cacgtcggag 300
acttggatga gctgtgtctg ccagatagcc ccgaatcggg acgaccgtgg tcacggtgcg 360
tctgaccact cgggtcgggt cgcccgcgct atcggcatgg gtgcgtnatc acagcgacac 420
gcgcctgccc aaggangtnc ggncggacc 449




53


160


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






53
cgggttgcgg atccacgcgt gcgggttgtc agcagctacg gcactgaacc gcgcccacag 60
ctcgccgatc cgctttcggt ggttctcgat cgactcgccg taggcgatgc gcagcgcctg 120
ctcgaatatc gggtacacgt aggccggcct tcccncttta 160




54


308


DNA


Mycobacterium tuberculosis



54
cttgattttg atcatcatga cgatcatcac cctaattttg ctacccgcac tggttatcgt 60
gggtaccgtc gtgctttcca tgggcgcctc tttcgggctt tccgtattgg tctggcagga 120
cattctgggt atcgatttgt actggatggt gttggcgatg tcggtgatcc tgctcctggc 180
ggtgggatcc gactacaatc tgctgctgat ttcccggttg aaaaaggaaa ttggggccgg 240
attgaacacc ggaattatcc gtgccatggc tggtaccggg ggagtggtga cggctgccgg 300
catggtgt 308




55


460


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






55
ggggatccct agatcgacct gcaggcatgc aagcttggcg tgtcgttcca acccgaattg 60
gctttcggcg ccatcggtga ggcgggacac acctcgatgc tgccgccatg gacgcggtcg 120
aacgcaagca gctgatcgag ctacaacgcc gcgcggaacg cttccgccgc gggcgtgacc 180
gcatcccgtt gaccgggcgg atcgcggtga tcgtcgatga cggcatcgcc accggagcna 240
ctgtcaaggc ggcgtgccag gtcgcccggg cgcacggtgc ggacaaggtg gtgctggcgg 300
tcccgatcgg cccagacgac atcgtggcga gattcgncgg gtacgccgat gaggtggtgt 360
gtttggcgac gccggcgtng ttcttcgccg ncgggcangg ttaccgcaac ttcacccaga 420
cctccgacga cgaggtggtg gcgtctcctg gatcgtgctc 460




56


299


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated as
“n”






56
aaggctgcag gtcgaagcgg ntggttacga ctccctgtgt gtgatggacc agttctacta 60
tctgcgtcta cacggccctt ggtgcgctgg ccacggcgac cgagcggctg caactgggcg 120
cgttggtgac cggcaatacc taccgcagcc ccgaccctgc tggcaaagat natcaccacg 180
ctcgacgtgg ttagcgccgg tcgagcgatc ctcggcattg gagccggcgg gtttgaactg 240
gaacaccgcc agctcggctt cgagtccggc acttccagtg accggttcaa ccggctcga 299




57


373


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






57
ctttccgcgg tacccgctca actttgtgtc gaccctcaac gccattgccg gcacctacta 60
cgtgcactcc aactacttca tcctgacgcc ggaacaaatt gacgcngcgg ttccgctgac 120
caatacggtc ggtcccacga tgacccagta ctacatcatt cgcacggaga acctgccgct 180
gctacagcca ctgcgatcgg tgccgatcgt ggggaaccca ctggcgaacc tggttcaacc 240
aaacttgaag gtgattgtta acctgggcta cggcgacccg gcctatggtt attcgacctc 300
gccgnccaat gttgcgactc cgttcgggtt gttccagang tcagcccggt cgtcatcgcc 360
gacgctctcg tcn 373




58


338


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






58
cggtcatagc cctcgggtcc ggccagcact ccgcaggctt cgtcggggtg gtcgcgacgc 60
gcatgggcca ccatcgcatt caccaggtct gcgcgaatca ccagcacgta gacggttcct 120
ttcctaagca acaccgaagt ttcacgaccc gaatgctccg ggaaacatgt cacggtaggt 180
cggtattccg gctaccggct gagcattgag cacgccggcc agcaccgcac gagccaggca 240
atcagccgcc gccgcaccga tcgcggtgac cagctgagtc tccggagaca atgcggccgg 300
cacgccggnc tccggcggca ccgctacngc gcccgtgg 338




59


374


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






59
gtgatggcac gccaccgcga caccacccgg ctgcgctacn tcgagccata ccgggcggag 60
ctacatcggc tcggccgccc agtgttcggg ccctctttcg aggtcgaggt cgataccgat 120
ttgcgcatcc gcanccgcnc cctggacgac agaaccgtgc cctacgagtg cttgtcgggc 180
ggggccaaag aacagcttgg catcctggcg cgattggccg gcgcggcgct ggtcgccaag 240
gacgacgccg ttccggtgct gatcgacgac gcgctggggt tcaccgatcc ggagcgacta 300
tcaagatggg ggaggtctct gacaccatcg gccccnacgg acatgtgatc gtgccgacgt 360
gcagtcccac cccg 374




60


448


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






60
gcgaaagtcc gttgggtgca atgatgtagc gcttctcccc atcgagatag tggagcaacg 60
caatccgtgc ggtacggttc gggtcgtact cgatgtgcgc gaccttggcg ttgacaccat 120
ctttgtcatt gcggcgaaag tcgatcatcc ggtnngcgcg cttatgaccg ccgcctttgt 180
gccgggtggt aatccggcca tgcgcgttgc gtccaccgcg accgtgcagc gggcgcacca 240
gcgacttctc cggggttgac cgggtgatct cggcgaaatc agatacgctg gcgccgcgac 300
gaccaggcgt cgtgggcttg tncttgcgaa ttgncatgtc taatcangtc tttctctcac 360
gctctcgtcg ccgggctagg ccgcattgcc ctgctcctcc tcatcgcttc gctctgcatc 420
gtccccgggc taagcccgtg ccccgaaa 448




61


356


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






61
gatggttcgc ggcacggtca acctgccaca cggcactggt aagactgccc gcgtcgcggt 60
attcgcggtt ggtgaaaagg ccgatgctgc cgttgccgcg ggggcggatg ttgtcgggag 120
tgacgatctg atcgagagga ttcagggcgg ctggctggaa ttcgatgccg cgatcgcgaa 180
caccggatca gaatggccaa agtcggtcgc atcgctcggg tgctgggtcc gcgcggcctg 240
atgcccaacc cgaaaaccgg caccgtcacc gccgactccc catggcgtcc cggatatcaa 300
gggccggcaa atcaacttcc cggttgatca gcaaggcaac ctgcctccnc ctccgg 356




62


336


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






62
atactcaagc ttcgtcataa gaccatggtg cgctttcttt cacccgtcca gagtcggggg 60
catccgcacc ggctcgcatc gcatcatcct cccacgacgg gccgctcatc agcttgggcc 120
atttcaatgt acttgatacc ccgcgctgcg ggtaggccac tgcgacaatt caaacacggt 180
gtcacacggt gaatagtgtc gagatgggct ctgatcaacc gtcgcaaacc cggtttcgca 240
tcaatagcgg aatcccaccg ggttgcatgg aggctgctga ccttggaaaa caaaattttt 300
tcattacaac aaaacaaccg ccncggaaac tttgca 336




63


489


DNA


Mycobacterium tuberculosis



63
cgaattcggc gtgcaccgct atgggttgca gcagcggctg gcgccgcaca ccccactggc 60
ccgggtgttt tcgccccgaa cccggatcat ggtgagcgaa aaggagattc gcctgttcga 120
tgctgggatt cgccaccgcg aggccatcga ccgattactc gccaccgggg tgcgagaggt 180
gccgcagtcc cgctccgtcg acgtctccga cgatccatcc ggcttccgcc gtcgggtggc 240
ggtagccgtc gatgaaatcg ctgccggccg ctacctgcaa ggtgattctg tcccgttgtg 300
tcgaagtgcc tttcgcgatc gactttccgt tgacctaccg gctggggcgt cggcacaaca 360
ccccggtgag gtcgtttttg ttgcagttgg gcggaatccg tgctctgggt tacagccccg 420
aactcgtcac ggcggtgcgc gccgacggag ttgttatcac cgatccgttg gccgtaccgc 480
gccttgggc 489




64


448


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






64
tcagactcca cccagccagc aggcagcgcg aagctgaatc ctccaaccgg gttgtcgatc 60
cggacaggtt ggggtgcgtt tggggcaatg acaggtggcg gcggtgcgtt cgggtcggcc 120
ggcggaggtg ctgcgttggg atcgcccggc tgggcattcn gcgtgttggc ggcggccggt 180
ggtggggggg caacaggtgt cgccggtgcg ggtggcgctg cagcggtcga cggcggcgaa 240
gcggccgttg tgggtaccgg gggcgctggc tccggatcgg cgttggcggt cgcgggcacc 300
gcaacggtca ccaagctggc gctggccatc gccgcgatag ccagtgccgc caatcgtccc 360
ttgcgacgtg tcaagtnggg gtccacctga tgcatggcca aagaacctac cgtgttaacg 420
gcncaacnca aggaccgcgc cggtcgcn 448




65


346


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






65
tttccgcggt acccgctcaa ctttgtgtcn accctcaacg ccattgccgg cacctactac 60
gtncactcca actacttcat cctgacgccg gaacaaattg acgcagcggg tccgctgaac 120
aattcggtcc gtcccacgaa agaaccagtt ttncntcttt cncacggaga acctgccgct 180
gctagagcca ctgcgatcgg tgccgatcgt ggggaaccca ctggcgaacc tgtgtttcaa 240
ccaacactta gagtgtaatt gtaaacctgg gctaggggaa accggctcta gtttttccac 300
cntctccgcc ccntgtttcg aatactccgt tcgggttgtc cccaaa 346




66


277


DNA


Mycobacterium tuberculosis



66
gcttccggct cgtatgttgt gtggaattgt gaccggatac caatttcaca caggaaacag 60
ctatgaccat gattacgcca agctagttag gtgacactat acaatactca agcttgccgg 120
ctggtgggcc gaccacttcg atggcacgac ccgtgaactg ctgcccggcc aattcttctt 180
ggtcgcccgg accgatggac cgcggctggg attccagaag gtgcccgatc ccgcccctgg 240
gaaaaaccgc gtgcacctct acttcacgac caacgac 277




67


434


DNA


Mycobacterium tuberculosis



67
ccgatcgact gatgcgccga caaccacgcc ccaacaactg gaatgaaccg tcgtgaccat 60
catcagcacg cggttgtagg cgacttgcga catgttcaac ccgccgtact cggacggaat 120
cttcaaaccg aaacagccca gctcggccag gcctttcacg tactcgtcgg ggatctgggc 180
accacgctcg aggacgctgc cgtccacggt gtctaggaat tcccgcagtt tgaccagaaa 240
cgcctcggtt cgggcctcct cggcgtccga cggcttggga aatgggtgta tgagccctac 300
gggaaaccgg cccacaaaga gttctttggc gaaggacggt ttatcccaac cactttcgcg 360
agattcctcg gcaagggccc gcgcttgctc ctcggtgacc tgagtttgct gtgccatcgc 420
cgcctcctcc ctga 434




68


465


DNA


Mycobacterium tuberculosis



68
tgcatccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca 60
gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc aagcttttac 120
ggtgatcgcg catcacctgg ttcatgaact ggaagcagcg cagcgcttcc ttttcggccg 180
caacatgagc cagcctctcg tcggcggtcg ggtgcaggtg ctcgggcagc tcggccgcga 240
cagccgcctg accctgaaac cagcttccat atcccgcgac gaacgacgcc agtccgctac 300
gtaacccctc cgcgactgtc catggacaac agcgcgttct ccaccgaccg ggcccgggtg 360
tggggtgttt cggcgaccgg cagccaggtg gtccacactg ccgacgggcg ccgcgagccg 420
ttcaccgacc aggccgccga gcaagtccgc ccgatcgcat actcc 465




69


463


DNA


Mycobacterium tuberculosis



69
gggggcgctg ctggtatagt cgctgaccgg tgcaggtttc gacaatgtgg tgccggttcg 60
gcggctacgt gccatcgaga cactggcgca ggctatcgca cccgttatcg gctacgagca 120
aatcgcggta tgcgttcttg agcatgagtc ggcgaccgtc gtcatggtcg acacccacga 180
cggaaagacg cagatcgccg tcaagcatgt gtgccgcgga ttatcaggac tgacctcctg 240
gctgaccggc atgtttggtc gcgatgcctg gcgcccggcc ggcgtggtcg tggtcggctc 300
ggatagcgag gtcagcgaat tctcgtggca gctcgaaagg gtcctgccgg tgccggtctt 360
tgcgcaaacg atggcgcagg ttacggtcgc gcggggtgcg gcctggcggc ggccagagca 420
cgagttcacc gatgcgcagc tagtggcgac agcgtcagcc aac 463




70


447


DNA


Mycobacterium tuberculosis



70
tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca 60
gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc aagcttccgt 120
acaggtcgcc tccaacacgg cggggaagcg acaccagcct accgagcttg gagtccagga 180
cgccagcggc ggcgtcggtc tgcgtcgtgg tgccgccggg gtggcgttgg ctggcaacga 240
tctccaccca gccggtcggg ttacccacga tctcggcata gacgcgggcc gaggccggtg 300
cgataccgta ttgcgtcaat tgggacgcgg ttgtgcattc ggctagctcg gttgccacac 360
ccgtcagggg ttcgacgttg gcgggttcgg cgggccccag caccgctgtc accatgcccg 420
ccaagccgac ctgcggcgcc accaact 447




71


460


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






71
cggcatgacc accgacaggc ccgactggtc gtaccactcg aacgccgggg tgttgatgtc 60
ccagccgctg aagtcgtcct gcgcgcgcag gccgtcgagc aggtacaggg cgggcgagtt 120
ggcaccacca ctttggaatt ggaccttgat gtcacggccc atcgacggcg acggcacctg 180
caggtactcc accggcaagc ccggccggga aaatgccccc gcggtcgccg tgccaccgac 240
ggcgccgacc agacccgaca ctagggccgc gccgacggcc ccgaccacga gtcgacgcga 300
catacccgtg acggcgccac gaaccctgtc aacaagctgc attcttgctt ccctcatcct 360
catctcaacg catccatgca tgtttgggcg catcctgaat tangtcagac tgcaggcgct 420
gggccggcag tgctcgtgta tcaaccacaa cttcgggcgt 460




72


404


DNA


Mycobacterium tuberculosis



72
ttccaaccct aattggcttt cggccccatc cgtgaggacg gggtgcgggt gctcaacaac 60
aacgtcgtcc gcgggacaca cctctatgct gccgccatgg acgcggtcca acgcaagcag 120
ctgatcgagc tacaaccccg cgcggaacgc ttccgccgcg ggcgtgaccg catcccgttg 180
accgggcgga tcgcggtgat cgtcgatgac ggcatcgcca ccggagcgac ggccaaggcg 240
gcgtgccacg tcgcccgggc gcacggtgcg gacaaggtgg tgctggcggt cccgatcggc 300
ccaaacgaca tcgtggcgag attcgccggg tacgccgatg aggtggtgtg tctggcgacg 360
ccggcgttgt tcttcgccct cgggcagggt taccgcaact tcac 404




73


465


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






73
caggcatgca agctttccgc cgatacccgc catgtcgcgc acatccagga cttctggggg 60
gatccgctga cagcggcggg atcccaaagt gcggatgatc gggccgccta cgtcgtggtg 120
tacctcgtcg gtaacaacga aaccgaagcg tatgactcgg tccacgcggt gcggcacatg 180
gtggacacca caccgccacc gcacggggtg aaggcctatg tcaccggtcc ggcagcactc 240
aatgccgacc aggccgaggc cggagacaaa agtatcgcta aggtcaccgc cgatcacnag 300
catggtgatc gcagcaatgt tgctagtgat ctatcgctcc gtaattaccg cggttctcgt 360
cttgatcatg gtcggcatcg actcggccaa tccgcggatt catcgccttg ctcgccgaac 420
acaacatttt cacctttcac atttgcacca acctgctctt ctcat 465




74


387


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






74
cactactcaa gctctctcnt cattaccacc cctgtaattt gggatgggca aaaaggcgaa 60
gcaccgcttg gccacnaacg ccgggaggga caatctcggg cggctatggc ttctcccggg 120
aaggccccaa cgtacggcgt ttcaacacgt cgcgtcgccc tccgaccgcg aacattcggg 180
gattggcacc aacctgntac caccctggcc gggcgatgat ctgcagcgtc gccgcgggta 240
gtccccgccc gggcggctac agtctgaaac cccgatgacc atcgatgtgt ggatgcagca 300
tccgacgcaa cggttcctac acggcggata tgttctcctc gctgcgccgg tggaccggtg 360
ggtctatccc ctgaaaccga catcccn 387




75


445


DNA


Mycobacterium tuberculosis



75
caggcatgca agctttcgtc agttcattgc gccagcagac caacaagagc atcgggacat 60
acggagtcaa ctacccggcc aacggtgatt tcttggccgc cgctgacggc gcgaacgacg 120
ccagcgacca cattcagcag atggccagcg cgtgccgggc cacgaggttg gtgctcggcg 180
gctactccca gggtgcggcc gtgatcgaca tcgtcaccgc cgcaccactg cccggcctcg 240
ggttcacgca gccgttgccg cccgcagcgg acgatcacat cgccgcgatc gccctgttcg 300
ggaatccctc gggccgcgct ggcgggctga tgagcgccct gacccctcaa ttcgggtcca 360
agaacatcaa cctctgcaac aacggcgacc catttgttcg gacggcaacc ggtggcaacg 420
cacctaagct acttgcccgg gatga 445




76


345


DNA


Mycobacterium tuberculosis



76
gtttatgcac tggttaggtg tttccatgag tttcattctg aacatccttt aatcattgct 60
ttgcgttttt ttattaaatc ttgcaattta ctgcaaagca acaacaaaat cgcaaagtca 120
tcaaaaaacc gcaaagttgt ttaaaataag agcaacacgt acacaaggag ataagaagag 180
cacatacctc agtcacttat tatcactagc gcccgccgca gccgtgtaac cgagcatagc 240
gagcgaactg gcgaggaagc aaagaagaac tgttctgtca gatagctctt acgctcagcg 300
caagaagaaa tatccaccgt ggggaaaaac tccaggtaga ggtac 345




77


139


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






77
atactcaagc ttgggtgtag ccgatcaccg gaagtcncat gatcagccac gttccgcgcc 60
gcccggcata cggtggtgta ccgatctccg cgtcatacac ccgcgggtaa tcgccgacgg 120
tgccggttcg cgagccgaa 139




78


298


DNA


Mycobacterium tuberculosis



78
agctttatcg aaagcgcgaa cagctcgcgg cggcccacga cgtgctgcgt cggattgccg 60
gcggcgagat caattccagg cagctcccgg acaatgcggc tctgctggcc cgcaacgaag 120
gactcgaggt caccccggtg cccggggtcg tggtgcacct gccgatcgca caggttggcc 180
cacaaccggc cgcttgatgc ccggtcggca agcccggcag ttgccaaacc catcgtgatc 240
aggctcggct cgcgagttcg gcgaagaaat ggttcgcctg atcacctacc atcggcca 298




79


300


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






79
tcaacacgcc gccagccacc acgcgcgggt cgggcgccgg gcccgggcct ccaggctnct 60
ccgctcggtg atggcacgcc accgcgacac cacccggctg cgctacgtcg agccataccg 120
ggcggagcta catcggcccg gccgcccagt gttcgggccc tctcgcccag gtcgaggtcg 180
acaccgattt gcgcatccgc agccgcaccc tgcgacgaca gaaccgcggc cctacccact 240
gcttgtcggg cgggggccaa agaaccagct tgncatcctg ccacaattgg ccggcgcccg 300




80


321


DNA


Mycobacterium tuberculosis



80
caggcatgca agcttcacgt ccgtacggct cgggtacgct tcggtcgcag tgtgcgagtg 60
atagatgacg accgggacct cgtcggcatc ttccatagcc cgccacacct tcagttgctc 120
accggaatcc aaccggtaga aggtcggcca gcgctcggca ttggtcatcg ggatatgccg 180
ctcgggacgg tcagagccct cgggtccggc cagcactccg caggcttcgt cggggtggtc 240
gcgacgcgca tgggccacca tcgcattcac caggtctgcg cgaatcacca gcacgtagac 300
ggttcctttc ctaagcaaca c 321




81


340


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






81
aatattcaag ctttcggcgg aaacggacnc cttgcgaaca ttgataacaa aatagaaatc 60
attgatggtt tgagtcacca ggccgatcaa gccttcgccg agccaaattc caatcaagag 120
gcccaagccc gtaccaatca gcccggcaac gagggattcc gtcnttatca gccnaaataa 180
ctgctctcgg gtaccaccca aacagcgcaa tatggcgaaa aacggtcgcc gttgcacaac 240
attaaatgtc tcggtattgt tgattaaaaa gatacccacc accagggcaa tccaactgag 300
agcggttaaa ttgaccgtaa aaacctcccg tcatctgttt 340




82


394


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






82
caggcatgca agcttgctgc atcttcctgt gactgctccc gaaacctggg ggtgtgcctg 60
ctgtgtatgc acggcatacg gacatccttc ccctgatacc cgcggtcgaa ccagccacgt 120
gtccatcatc aggggtcaac cccggccaag ggcgacggca cgccaagttc gccgaccgtt 180
aacctagtgc tgttagcttc atttgctgcg agcaaaacag ctggtcggcc gttaggaact 240
gaattgaaac tcaaccgatt tggtgccgcc gtaagtgtcc tgtctgcggg tgcgctggtg 300
ttgtccgcgt gtggtaacga cgacaatgtg accgggggag gtgcaaccac tggccaggcg 360
tccgcgaaag tccattgcng ggggaagaag acac 394




83


487


DNA


Mycobacterium tuberculosis



83
gaaagtgccc caaggtgttg gtgaaactcg ctggacggtc cccaggatgt tggcagcaca 60
ttcaccggac atgaccggag caagaccgga catcctccca taccgtcgtc gccgtgtaca 120
tccgtagccc gtcctggcag gtgctgggtt gaacaaaatc agcccaacac ctgccacgac 180
gaagaagcgg gttgcgctgg catgtcttgt cggctcggcg atcgaattct acgaattcct 240
tatctacggg accgctgcgg cgctggtgtt tcccaccgtg ttcttcccac acctggatcc 300
cacggtggcc gccgtggcct ccaaggggac atttgctgtg gcgttcctat cccggccgtt 360
cggcgcggcc gtctttggat actttggaga ccgcctcggc cgccagaaga ccctggtcgc 420
cacactgttg atcatgggcc tggcaaccgt gactgttggg ctggttccac gacagtggcc 480
atcgcgc 487




84


418


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






84
atattcaagc tttgtcacac caagtgttcc gaccaancgc tccatccggc gagtggatac 60
tcccagcagg tagcaggtcg ccaccacgct ggtcagtgcg cgttcatctc gcttgcggcg 120
ctgcagcagc cagtccggga aatagctgcc ctggcgcagc ttggggatcg cgacgtcgat 180
ggttgcggca cgggtgtcga aatcacggtg gcggtagccg ttgcgctgat tggaccgctc 240
atcgctgcgt tcgcggtagc ccnccccgca cagggcgtcg gcttcagccc ccatccaagg 300
cggcgatgaa cgtcgagagc agcccgcgca gcaaatccgg gctcgcctgt gcgagttggt 360
cagccagaag ctgctcggtg tcataagatg agaagaggtc agtgcgtcct ttccttcg 418




85


399


DNA


Mycobacterium tuberculosis



85
caggcatgca agctttttga gcgtctcgcg gggcagcttc gccggcaatt ctactagcga 60
gaagtctggc ccgatacgga tctgaccgaa gtcgctgcgg tgcagcccac cctcattggc 120
gatggcgccg acgatggcgc ctggaccgat cttgtgccgc ttgccgacgg cgacgcggta 180
ggtggtcaag tccggtctac gcttgggcct ttgcggacgg tcccgacgct ggtcgcggtt 240
gcgccgccaa agcggcgggt cgggtgccat catgaatgcc tcaccgccgc cgcactgcac 300
ggccagtgcc ccggcgatgt cagccatcgg gacatcatgc tcgcgttcat actcctcgac 360
cagtccgcgg aacagctcca ttcccggacc gcccaacgc 399




86


474


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






86
atactcaagc ttttggctgg gtcgccttcc aattcagcgt gcaccgctat gggttgcagc 60
agcggctggc nccgcacacc ccactggccc gggtgttttc gccccgaacc cggatcatgg 120
tgagcgaaaa ggagattcnc ctgttcgatg ctgggattcg ccaccgcgag gccatcgacc 180
gattactcgc caccggggtg cgagaggtgc cgcagtcccg ctccgtcgac gtctccgacg 240
atccatccgg cttccgccgt cgggtggcgg tagccgtcga tgaaatcgct gccggccgct 300
accacaaggt gattctgtcc cgttgtgtcc aagtgccttt cgcgatcgac tttccgttga 360
cctaccggct ggggcgtcgg cacaacaccc cggtgaggtc gtttttgttg cagttgggcg 420
gaatccgtgc tctgggttac agccccgaac tcgtcacggc ggtgcgccgc cgac 474




87


383


DNA


Mycobacterium tuberculosis



87
caggcatgca agcttcaacc tattgacgca ttgtgcgaac tgacggcgcc cgcgcatggc 60
caatccggaa gaccatcatt ggccagtggc cgggcgctaa caggttccag ccccccacca 120
gtgccgctcg aacatgcggt gcaacccatt cgcaggccgg cagggaaagc accgcggaag 180
ccgcaaaggg ctgcagttcc gcgcccaata gtgtcgtccg caaccagatg cgctcgaaaa 240
ccgccgccgg cagtcagcgc acccgacgcg aggtcgagag acgtcgtcag cgcgcccaca 300
tggggtgcca atcggcacgg caggtaggcc gcgcgcaacc ccaacgcgtg gtgcatgcca 360
cggtccgcag gaggccacca ccc 383




88


455


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






88
atactcaagc ttcccggccg caggtgacgg cgcggcctag cgccacttga tgccgcaccc 60
gatcgacggn cgttggtcgg ggttgactgg ccgcccggcg agcagggcgt caaccgcggc 120
ccggacgtcg gcggccgtca ccggtcggcc attgcccggg cgggagtcgt cgagctgacc 180
acggtagaca agtcggcgct ggccgtcgaa gacaaacgtg tcgggtgtgc aggccgcgga 240
gaaggcgcng gcgacgtctc gggtttcgtc gtagagatac gggaacgtcc agccgtggcg 300
gcgggcctcg gcgaccatct gatcgggccc gtcctgcggg taggtgacca cgtccttact 360
ggagataccg accatcggga ccctttgatc ggcgaggtcc cggccgaccg tggccaatcc 420
ggcggcgacg tgtcgcccgt accggccagt ggttc 455




89


429


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






89
caggcatgca agctttanca ncatcaaccc cgccccgcac cagcaccgac acgatgtcga 60
tgccatcgag gtgaatgtcg aactggcnca aaccatctgg cgaccgcgac caccggcaac 120
atgggtaccg gcgatttccg gtgccaatgc cgacccgacg ggccgctctc accgcaggtg 180
acctcgatca ccgagaccag ccggccgtta tactcacgca cccctaccgt gtcacgccca 240
aaacggcgct ggtggtcgat tgccggagtg caccccgcac ccagtgtcgt gcccggatcc 300
gccgaccaat cccgcaccca cgtcgccaaa cccgaaatca ccgtgatgcc gtggtaactg 360
accaccgaca gtaacgtcac tacggccgcc acgccgacgc cgaaccacca cgcacatgat 420
gatcggctg 429




90


321


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






90
atattcaacc ttgcacacat tgacgatacc ttggtcacga gaccccaaaa gctggcctcc 60
accgcgcgcc ggggaccacg gtcatacctt ganncngctt tcgatcgttg atgctgcgtc 120
ttggtccgcg gaaaccgcag gctggcatat gcacgtgggc gcactggcga tctgcgatcc 180
ccaccgattc gcccgaatac agctttcagc ggctccccaa gttgatcatc gaccggctgc 240
cggatatccc gcacttgcgg tggcgggtca ccggcgcccc gctcggactg gaccggccgt 300
ggttcgtcga ggaccacgaa c 321




91


134


DNA


Mycobacterium tuberculosis



91
caggcatgca agcttcatgc ccgcggcatg atagccacat gcacgcaatc gaactcagcg 60
aaaccggcgg gccaggcgtc ttacgccacc tcaccagcgc gcaacctcaa cccggccacg 120
gagacctcct gatc 134




92


513


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






92
atactcaagc ttgattttga tcatcatgat gatcatcacc cgaattgtgg tagccgcagt 60
ggttatcgtg ggtaccgtcg tgctttccat gggcgcctct ttcgggcttt ccgtattggt 120
ctggcaggac attctgggta tcgagttgta ctggatggtg ttggcgatgt cggtgatcct 180
gctcntggcg gtgggatccg actacaatct gctgctgatt tcccggttga aagaggaaat 240
tggggccgga ttgaacaccg gaattatccg tgccatggct ggtaccgggg gagtggtgac 300
ggctgccggc atggtgttcg ccgttaccat gtcgttgttt gtgttcagcg atttgcgaat 360
tattggtcag atcggtacca ccatcggcct gggcttgctg ttcgacaccc tcgtcgtgcc 420
tcgttcatga aaccgtccat tgctgccctg ctgggacctg gttctggtgg ccgctacggg 480
tgcgcccgcg cccggcagtc aaatcttccg ccg 513




93


345


DNA


Mycobacterium tuberculosis



93
caggcatgca agcttggcgt gccgttccaa cccgaattgg ctttcggcgc catcggtgag 60
gacggcgtgc gggtgctcaa cgacgacgtc gtccgcggga cacacctcga tgctgccgcc 120
atggacgcgg tcgaacgcaa gcagctgatc gagctacaac gccgcgcgga acgcttccgc 180
cgcgggcgtg accgcatccc gttgaccggg cggatcgcgg tgatcgtcga tgacggcatc 240
gccaccggag cgacggccaa ggcggcgtgc caggtcgccc gggcgcacgg tgcggacaac 300
gtggtgctgg cggtccccat cggcccagac gacatcgtgg cgaga 345




94


302


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






94
atactcaagc ttttacggtg atcgcgcatc acctggttca tgaactggaa gcagcgcagc 60
gcttcctttt cggccgcaac atgagccagc ctctcgtcgg cggtcgggtg caggtgctcg 120
ggcagctcgg ccgcgacagc cgcctgaccc tgaaaccagc ttccatatcc cgcgacgaac 180
gacgccagtc cgctacgtaa cccctccgcg actgtccatg gacaacagcg cgttctccac 240
cgaccgggcc cgggtgtggg gtgtttcggc gaccggcagc cangtggtcc acactgccga 300
ag 302




95


286


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






95
tagtcgctga ccggtgcagg tttcgacnat gtggtgccgg ttcggcggct acgtgccatc 60
gagacactgg cgcaggctat cgcacccgtt atcggctacg agcaaatcgc ggtatgcgtt 120
cttgagcatg agtcggcgac cgtcgtcatg gtcgacaccc acgacggaaa gacgcagatc 180
gccgtctanc ntgtgtgccg cggattatca ggactgacct cctggctgac cggcatgttt 240
ggtcgcgatg cctggcgccc ggccggcgtg gtcgtggtcg gctcgg 286




96


482


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






96
atactcaagc tttccgccga tacccgccat gtcgcgcaca tccagaactt ctggggggat 60
ccgctgacag cggcgggatc ccaaagtgcg gatgatcggg ccgcctacgt cgtggtgtac 120
ctcgtcggta acaacgaaac cgaagcgtat gactcggtcc acgcggtgcg gcacatggtg 180
gacaccacac cgccaccgca cggggtgaag gcctatgtca ccggtccggc agcactcaat 240
gccgaccagg ccgaggccgg agacaaaagt atcgctaagg tcaccgcgat cacgagcatg 300
gtgatcgcag caatgttgct agtgatctat cgccccgtaa ttaccgcggt tctcgtcttg 360
atcatggtcg gcatcgacct cggcgcaatc cgcggattcn tcgccttgct cgccgaccac 420
aacattttca gcctttcaac atttgcgaca acctgctcgt tctcatggcg attgcngcga 480
ac 482




97


395


DNA


Mycobacterium tuberculosis



97
caggcatgca agcttggcgt gccgttccaa cccgaattgg ctttcggcgc catcggtgag 60
gacggcgtgc gggtgctcaa cgacgacgtc gtccgctgga cacacctcga tgctgccgcc 120
atggacgcgg tcgaacgcaa gcagctgatc gagctacaac gccgcgcgga acgcttccgc 180
cgcgggcgtg accgcatccc gttgaccggg cggatcgcgg tgatcgtcga tgacggcatc 240
gccaccggag cgacggccaa ggcggcgtgc caggtcgccc gggcgcacgg tgcggacaag 300
gtggtgctgg cggtcccgat cggcccagac gacatcgtgg cgagattcgc cgggtacgcc 360
gatgaagtgg tgttgtttgg cgacccggcg ttgtt 395




98


439


DNA


Mycobacterium tuberculosis



98
atactcaagc tttggcattg tgcacatttt ccacccgtgc tctattaatg ctgagccgct 60
aattgtgacc ccagtcggga aacacgcgga gcaccaaatt caccgcagcg gccggggcgg 120
ttcaactcac catggatcgc tctcgtcgtc tggtgctgga caatcgtcgc tgtagcgcgt 180
cgcgaacacc tcagcttctg ctgccgcggc ttcttccggc gatggtaacc cccaggtttc 240
gcccacggtc ttacgtagca gtgcgacgcg gtgttcatct gcatcgacct gttgactcat 300
cctgtcaagg atgaaggcgt actgggccga ctgcgccttc tgccgcgcca ggtcggcaat 360
caccaggatc tcagaaacga gctgcgactc actcttccag gccaccctgg ccgaaagctc 420
gacatggtca atccggccg 439




99


348


DNA


Mycobacterium tuberculosis



99
caggcatgca agcttgcggg ccggagtggt ttcgacggcc gctcgcttct cggcatcggt 60
ttgggctgtc accagcagtt ggtagttctt cacgtactgt tgttcgagcg tcgagccgcc 120
gcgcgtgtcg aggtcgccgg acgcgtatcc cgccaggccg gtcagggtgc ccttccagtc 180
cacgccgctg tggtcggcga accgcttatc ttcaatcgag acgatcgcca gcttcatcgt 240
gttggcgatc ttgtccgagg gcacctcgaa ccggcgctgc gagtacagcc acgcgatcgt 300
gttgcccttc gcgtcgacca tcgtcgatac cgcaggcact tgcccctc 348




100


436


DNA


Mycobacterium tuberculosis



100
atactcaagc ttcccggcgg ccagtaccga aagcgcgaac agctcgcggc agcccacgac 60
gtgctgcgtc ggattgccgg cggcgaaatc aattccaggc agctcccgga caatgcggct 120
ctgctggccc gcaacgaagg actcgaggtc accccggtgc ccggggtcgt ggtgcacctg 180
ccgatcgcac aggttggccc acaaccggcc gcttgatgcc cggtcggcaa gcccggcagt 240
tgccaaaccc agcgtgatca ggctcggctc gcgagttcgg cgaagaagtg gctcgcctga 300
tcacctacca tcggccagga tctgcgtgtc atcacaacgc tcgccaagga ggttgttgtg 360
gtgctatcga cggcctttag ccagatgttc ggaatcgact atccgatagt gtccgcgcca 420
atggacttga tcgccg 436




101


445


DNA


Mycobacterium tuberculosis



101
agcttcggtg tagccgatca ccggaagccg catgatcagc cacgtttcgc gccgcccggc 60
atacggcggc gtaccgatct ccgcgtcata cacccgcggg taatcgccga cggtgccggt 120
tcgcgagccg aaggtgacga cgctgattga atcgagttcc aggtccagcg ggtggcgcag 180
caacggcgcg agctcaacga cgtcaatcac gttgtcgctt tctacggtca ccgacccggt 240
gaccgtagtc gcccggtgcg ctcggccgag aagttgcacc gccaccaccg cgacaccgtc 300
ttgcacgcgg acgccacccc cggatcggtt gttggccaag gtaattgggt cattccattt 360
gacgggacgc cgaccccgca gccccagtac cgcccacgac cacgccggct gacccaccac 420
tgtacgaaca ccaaggcgac gccga 445




102


261


DNA


Mycobacterium tuberculosis



102
atactcaagc ttcggtggct tcgcccgccc tgccgggtgg acttcatgac aacgcggggg 60
cgattacccc cgctaccgcc agcagcatga cggcggtacc taacaccgcc cggatgcctc 120
gcacgtgcct cgatgtgctc acggaatcgc cccggcaccg cgatctcgag gatcaccagc 180
gttacccccg gcagcgcgac accgacaatt ccgtacaccg ccacgccgat ccggccctgg 240
gccagctgat tggagctggc g 261




103


244


DNA


Mycobacterium tuberculosis



103
caggcatgca agcttccaca tgtacggatc cacgaacatc ccgttgaact gacaggtgcg 60
gcccggctcg atcaggccgg ccacttgttc tacgcggtta ccgaagatct cttcggtgac 120
ctgcccgccg ccggccagct cggcccagtg cccggcgttg gccgccgcgg cgacgatctt 180
ggcgtccacg gtggtccggg tcttgcccgc tagcacgatc cgcgagtcgg ccggtcaccc 240
gggt 244




104


376


DNA


Mycobacterium tuberculosis



104
atactcaagc tttccaagtc ccaagtgtcg atcatggcca aagagctcga caaagccgta 60
gaggcgtttc ggacccgccc gctcgatgcc ggcccgtata ccttcctcgc cgccgacgcc 120
ctggtgctca aggtgcgcga ggcaggccgc gtcgtcgggg tgcacacctt gatcgccacc 180
ggcgtcaacg ccgagggcta ccgaaagatc ctgggcatcc aggtcacctc cgccgaagac 240
ggggccggct ggctggcgtt cttccgcgac ctggtcgccc gcggcctgtc cggggtcgcg 300
ctggtcacca gcgacgccca cgccggcctg gtggccgcga tcggggccac cctgcccgca 360
gcggcctggc agcgct 376




105


284


DNA


Mycobacterium tuberculosis



105
caggcatgca agcttcacac gtaggcgccg tcgataaatg actccgccgc gcttcgcaca 60
tcctcgtagc gatccttggc gagcaggtca accgggcgct gcccgtcgag gagccggttt 120
ttggcgtgca gccactggcc gacacctcgg ggggtaagcg aatccgagag caggaggacg 180
aggtcacgaa gctgcgccag ccggtcgtac cgctcagggc ggatgtcgcc ggtccgccac 240
ccgcgtaccg cccgatcgga cacctgtatg accgcggcga cgtc 284




106


140


DNA


Mycobacterium tuberculosis



106
cgcggcggcg cattaccccc gctaccgtca gcagcttgac ggcggtagcg aacaccgccg 60
gatgcagcgc aggtgcgtct atgtgcacac ggaatcgccc cggcaccgcg atctcgagga 120
tcaccagtgc ccgccccctg 140




107


491


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






107
gggatcgagg aacagcgcgt tgaactgata ggtgcggccc ggctcgagca ggccggccat 60
ttgttcgatg cggttaccga agatctcttc ggtgacctgc ccgccgccgg ccagctcggc 120
ccagtgcccg gcgttggccg ccgcggcgac gatcttggcg tccacggtgg tcggggtcat 180
gcccgcgagc aggatcggcg agcggccggt cagccgggtg aacttcgtcg agagcttgac 240
cctgccgtcg gggaggcgaa ccacggtcgg tgcgtatctc gaccaggccc gggcaacctc 300
gggggtggcg ccgacggtga acaggttgcg ctggccaccg cgggtagccg ccggcactat 360
gccgatgccc aggccgcgga tcaccggtgc ggtcagtcgg gtcaggatgt cgcccggccc 420
caggtcgaag atccagcggg cgccggccgc gtggacacng gtgatctcgt ccaccatcga 480
ctttctgatc a 491




108


364


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






108
taactcaagg cttgcgttga ggccccaggc ccatcgacgg tttggcggcc ttaaatgcac 60
tgaggtcgtc aattgacccc acagcggaaa tgccgactat tcgcaggcct ccttcgcctt 120
ggctgccgga gaggggctcc gcgggaaccg catgcaggta tatgacctcg gtttctcggg 180
tgctaccgcg tgccttgtcg aggatgaact cggcgttgga attgtccagc cggcccaatt 240
catcgagcgc agattcgtac acatggccgg cggcgacata cgcttcaccg tggatctgct 300
ccacacggac cgccctgtcg ggatcctgct cacgggtaaa ggaacttacn tggcnctcgg 360
tgcc 364




109


453


DNA


Mycobacterium tuberculosis



109
ccttctgcgc cacccacacc gtcaacgccc gcgaagtcga cgtcgtccag gccatcggcg 60
gcctcacgga tggattcggc gcggacgtgg tgatcgacgc cgtcggccga ccggaaacct 120
accagcaggc cttctacgcc cgcgatctcg ccggaaccgt tgtgctggtg ggtgtgccga 180
cgcccgacat gcgcctggac atgccgctgg tcgacttctt ctctcacggc ggtgcgctga 240
agtcgtcgtg gtacggcgat tgcctgcccg aaagcgactt ccccacgctg atcgaccttg 300
acctgcatgg ccggctgccg ctgcagcggt tcgtttccga acgcatcggg ctcgaagacg 360
tcgaggaggc gttccacaag atgcatggcg gcaaggtatt gcgttcggtg gtgatgttgt 420
gatggccgcc atcgagcgcg tcatcaccca cgg 453




110


329


DNA


Mycobacterium tuberculosis



110
atactcaagc ttgattttga tcatcatgat gatcatcacc cgaagtgtgg tagccgcagt 60
ggttatcgtg ggtaccgtcg tgctttccat gggcgcctct ttcgggcttt ccgtattggt 120
ctggcaggac attctgggta tcgagttgta ctggatggtg ttggcgatgt cggtgatcct 180
gctcctggcg gtgggatccg actacaatct gctgctgatt tcccggttga aaaaagaaat 240
tggggccgga ttgaacaccg gaattatccg tgccatggct ggtaccgggg gagtggttac 300
cgctgccggc atggtgttcg ccgttacca 329




111


438


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






111
attgnctttc ggcgccatcg gtgaggacgg cgtgcgggtg ctcaacgacg acgtcgtccg 60
cgggacacac ctcgatgctg ccgccatgga cgcggtcgaa cgcaagcagc tgatcgagct 120
acaacgccgc gcggaacgct tccgccgcgg gcgtgaccgc atcccgttga ccgggcggat 180
cgcggtgatc gtcgatgacg gcatcgccac cggagcgacg gccaaggcgg cgtgccaggt 240
cgcccgggcg cacggtgcgg acaaggtggt gctggcggtc ccgatcggcc cagacgacat 300
cgtggcgaga ttcgccgggt acgccgatga ggtggtgtgt ttggcgacgc cggcgttgtt 360
cttcgccgtc gggcagggtt accgcaactt cacccagacc tccgacgaag aagtggtggc 420
gttttctgga tcgtgctc 438




112


438


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






112
atactcaagc ttttcccgtc cgtcatcgcc caagcgcgtg aggccgaagc ggctggttac 60
gactccctgt ttgtgatgga ccacttctac caactgccca tgttggggac gcccgaccag 120
ccgatgctgg aggcctacac ggcccttggt gcgctggcca cggcgaccga gcggctgcaa 180
ctgggcgcgt tggtgaccgg caatacctac cgcagcccga ccctgctggc aaagatcatc 240
accacgctcg acgtggttag cgccggtcga gcgatcctcg gcattggagc cggttggttt 300
gagctggaac accgccagct cggcttcgag ttcggcactt tcagtgaccg gttcaaccgg 360
ctcgaanagg cgctacagat cctcgagcca atggtcaagg gtgagcgcca acgtttttcg 420
gcgattggta cccaccga 438




113


482


DNA


Mycobacterium tuberculosis



113
cggccaccgg ggccactccg cacaatctgt acccgaccaa gatctacacc atcgaatacg 60
acggcgtcgc cgactttccg cggtacccgc tcaactttgt gtcgaccctc aacgccattg 120
ccggcaccta ctacgtgcac tccaactact tcatcctgac gccggaacaa attgacgcag 180
cggttccgct gaccaatacg gtcggtccca cgatgaccca gtactacatc attcgcacgg 240
agaacctgcc gctgctagag ccactgcgat cggtgccgat cgtggggaac ccactggcga 300
acctggttca accaaacttg aaggtgattg ttaacctggg ctacggcgac ccggcctatg 360
gttattcgac ctcgccgccc aatgttgcga ctccgttcgg gttgttccca gaggtcagcc 420
cggtcgtcat cgccgacgct ctcgtcgccg ggaccagcag ggaatcggcg atttcgccta 480
ca 482




114


388


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






114
atactcaagc ttggggtggc gctgtcggtc ggtgtgcttg gcggcgtcgg tatcaacacc 60
gcccacgaaa tggggcacaa gaaggattcg ctggagcggt ggctgtccaa aatcaccctc 120
gcccagacct gctacgggca cttctacatc gagcacaacc gtggccatca cntccgggtg 180
tccacaccgg aggacccggc gtcggcgcgg ttcggcgaaa cgttgtggga gttcctgccc 240
cgcagtgtta tcggcggctt gcgctcggcc gttcatttgg aggcccaacg gctgcgtcgg 300
ctcggcgtca gcccctggaa tcccatgacg tatctgcgca acgacgtgcn caacncgtgg 360
ctgatgtcng tggtgttgtg gggtgggc 388




115


455


DNA


Mycobacterium tuberculosis



115
tcgccaccgc accgcggcga acgctcaaag gcacctactg gcaccaaggc cccacacgtc 60
accctgtgac ctcctgcgcc gaccccgccc gaggtcctgg ccgttaccac cgaacgggcg 120
agccgggagt ctggtacgca tcgaacaaag agcaaggtgc atgggcggag ttgttccgcc 180
acttcgtcga tgacggggtc gatccattcg aggtccgtcg ccgcgtcggt cgagtggcgg 240
tcacactcca ggtactcgac ctcacagacg agaggactcg atcccatcta ggtgtggacg 300
aaacagatct tctgtccgac gactacacca ccacccaggc catcgccgcc gcccgcgatg 360
ccaacttcga cgccgtactg gccccggcgg cggcgctccc cggttgtcaa acactttgcc 420
gtgttcgttc acgcactgcc caacatcgag cccga 455




116


328


DNA


Mycobacterium tuberculosis



116
atgaaataag aagagcacat ccctcagtcg gttatcatca ctagcgctcg ccgcacccgt 60
gtaaccgatc atagcgagcg aactggcgag gaagcaaaga atatctgttc tgtcagatag 120
ctcttacgct cagcgcaaga agaaatatcc cccgcgggaa caactccagg tagaggtaca 180
cacgcggata gccaattcag agtaataaac tgtgacactc acaccctcat caatgatgac 240
gaactacacc ccgatatccg gtcacatgac gaagggaaag agaaggatat catctgtgac 300
aaactgccct caaatttggc ttccttaa 328




117


318


DNA


Mycobacterium tuberculosis



117
atactcaagc ttgtcgaact ccttcttgaa taccggccgg ccatccacag atgcccggaa 60
gaacttccag gtacccatgg cggctggatc agggggcggc acagttggtc ttgtcctgcc 120
tcgagtggcg tcgttgtccg gcttggacgg ggctccgacg gtaccggagg gcagcgacaa 180
aacacttatg cacttgggcg acccgccgag acggtgcgac acccatcccg acggcacaag 240
ctcagccgcg gccgctcttg ttcttcgtcg gatcgacatt cacccacttc tgaccgggct 300
tgggcgaagg aagcagaa 318




118


405


DNA


Mycobacterium tuberculosis



118
ggtatagtcg ctgaccggtg caggtttcga caatgtggtg ccggttcggc ggctacgtgc 60
catcgagaca ctggcgcagg ctatcgcacc cgttatcggc tacgagcaaa tcgcggtatg 120
cgttcttgag catgagtcgg cgaccgtcgt catggtcgac acccacgacg gaaagacgca 180
gatcgccgtc aagcatgtgt gccgcggatt atcaggactg acctcctggc tgaccggcat 240
gtttggtcgc gatgcctggc gcccggccgg cgtggtcgtg gtcggctcgg atagcgaggt 300
cagcgaattc tcgtggcagc tcgaaagggt cctgccggtg ccggtctttg cgcaaacgat 360
ggcgcaggtt acggtcgcgc ggggtgcggc cctggcggcg gccca 405




119


89


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






119
gacactatat natactcaag cttcaggtca atgtgcgcca agccctgacg ctggccgacc 60
aggccaccgc cgccggancc ctntctaga 89




120


354


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






120
ctgtagccac ctgttgccat ccccgtcatg cccgactctg gtcatctcgg atccgctgac 60
accccgctaa ggctgctcct ctcggtgcat tacctcaccg acggcgaacn cccccagctt 120
tacgactatc cggatgacgg cacctggttg ccggctaact tcaccgtcag cttggacggc 180
ggcgctaccg tcgatggcgc cagcggggcg atggccgggc ccggcgaccg attcgtcntc 240
ancctgtcgc gtgaacttgc cgacgtcatc gtggtcggtg tgggcaccgt gcgcattgag 300
ggctactccg gcgtccggat gggtgtcgtc aagcgcccgc accggcaggc ccga 354




121


379


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






121
atactcaagc ttcgcacgct cggcgcgcgc ggtaccgccc aggtcgccca acagatcgtc 60
gatgttcgcg tcgtccgcct cgcgcacgtg gtctgtcacc agtcaacgtt aacgccgccg 120
cacatgtcct gcggccgggc aaaaacgtga aaaacgagcg ggcgactgcn atgtcatgac 180
accgacggcc gccgatgggc ccagggtctg gcaaattcga tctgtgcggc cagtgccagc 240
agcgtcgcct cgtcatacgg ccggccgacg agttgaaccg acatgggcag gccgtcgccg 300
tcgaagtccc acggcaccac gggcgcgggc tggccggtca gattccaaaa ttgaaagtac 360
ggaaccgctg caccaccaa 379




122


393


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






122
atcgtttcga ccaggcgctc catccggcga gtggatactc ccagcaggta gcaggtcgcc 60
accacgctgg tcagtgcgcg ttcagctcgc ttgcggcgct gcagcagcca gtccgggaaa 120
tagctgccct ggcgcagctt ggggatcgcg acgtcgatgg ttgcggcacg ggtgtcgaaa 180
tcacggtggc ggtagccgtt gcgctgattg gaccgctcat cgctgcgttc gcggtagccc 240
gccccgcaca gggcgtcggc ttcagccccc atcaaggcgg cgatgaacgt cgagagcagc 300
ccgcgcagca gatccgggct cgcctgtgcg agttggtcag ccagaagctg ctcggtgtcg 360
ataagatgan aagaagtcat tgcgttattt cct 393




123


333


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






123
atactcaagc ttgggtgttg ccgatcaccg gaagccgcat gatcagccac gtttcgcgcc 60
gcccggcata cggcggcgta ccgatctccg cgtcatacac ccgcgggtaa tcgccgacgg 120
tgccggttcg cgagccgaag gtgacgacgc tgattgaatc gagttccagg tccagcgggt 180
ggcgcagcaa cggcgcgagc tcaacnacgt caatcacgtt gtcgctttct acggtcaccg 240
acccggtgac cgtagtcgcc cggtgcgctc ggccgagaag ttgcaccgcc accaccgcga 300
caacgtcttg cacgcggacg ccaccccccg gat 333




124


426


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






124
gcgcnaacag ctcgcggcag cccacgacgt gctgcgtcgg attgccggcg gcgagatcaa 60
ttccaggcag ctcccggaca atgcggctct gctggcccgc aacgaaggac tcgaggtcac 120
cccggtgccc ggggtcgtgg tgcacctgcc gatcgcacag gttggcccac aaccggccgc 180
ttgatgcccg gtcggcaagc ccggcagttg ccaaacccag cgtgatcagg ctcggctcgc 240
gagttcggcg aaaaagtggc tcgcctgatc acctaccatc ggccaggatc tgcgtgtcat 300
cacgacgctc gccaaggagg ttgttgtggt gctatcgacg gcctttagcc agatgttcgg 360
aatcgactat ccgatagtgt ccgcgccaat ggacttgatc gccggcggtg agctggctgc 420
cgcngt 426




125


336


DNA


Mycobacterium tuberculosis



125
atactcaagc tttctccgat acccgccatg tcgcgcacat ccaggacttc tggggggatc 60
cgctgacagc ggcgggatcc caaagtgcgg atgatcgggc cgcctacgtc gtggtgtacc 120
tcgtcggtaa caacgaaacc gaagcgtatg actcggtcca cgcggtgcgg cacatggtgg 180
acaccacacc gccaccgcac ggggtgaagg cctatgtcac cggtccggca gcactcaatg 240
ccgaccaggc cgaggccgga aacaaaagta tcgctaaggt caccgcgatc acgaacatgg 300
tgatcgcagc aatgttgcta gtgatctatc gctccg 336




126


347


DNA


Mycobacterium tuberculosis



126
ccatgagcac cgccagccga gcacgaggcc aaactccgcc gacgcaggcc ggttggactt 60
gtcgtgctgg acaaggggtt tagccgccga agcagtgacg tacatcggcg aagagcagtt 120
cgcctgtcga ccgacggcgc aaaccgtgag gctagggaag cgaggagcac atggccgccg 180
acccgcaatg tacacgctgc aagcaaacca tcgaacccgg atggctatac atcaccgccc 240
atcgccgcgg tcaagccggg atcgtcgatg acggcgcagt actgattcac gtgcccggtg 300
aatgccgcac cccggggagc actttccgcc aaaactaacc cggttgg 347




127


315


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






127
cgggtgtcat tggccaccgg cggcggctgt ccgggaaatg gcgggtcccc ggtggttttg 60
ctgaggagtg ctgaaccgta gtcgaagtgg gcggcgtcag actccaccca gccagcaggc 120
agcgcgaanc tgaatcctcc aaccgggttg tcnatccgga caggttgggg tgcgtttggg 180
gcaatnacag gtggcggcgg tgcgttcggg tcggccggcg gaggtgctgc nttgggatcc 240
ccggctgggc attcggcntg ttggcggcgg ccggtggtgg ggggggcaac acgtgtcncc 300
ggtgcgggtg gccct 315




128


354


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






128
ccaagatcta caccatcgaa tacgacggcg tcgccgactt tccgcggtac ccgctcaact 60
ttgtgtcgac cctcaacgcc attgccggca cctactacgt gcactccaac tacttcatcc 120
tgacgccgga acaanttgac gcagcggttc cgctgaccaa tacggtcggt cccacgatga 180
cccagtacta catcattcgc acggagaacc tgccgctgct agagccactg cgatcggtgc 240
cgatcgtggg ganacccact ggcgaacctg ggttcaacca aacttgaagg tgattgttaa 300
cctgggctac ggcgacccgg cctatggtta ttcgacctcg ccgcccaaat gttg 354




129


360


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






129
agcttcccga gttcggcttt ggatcaagac cccagtccgc gggcgcgatc cggcngctcg 60
gtgactacat caagccacaa atcgacggct ttcggggtgc cgataccgat gacgtggcgg 120
atgtcgagtg ttgagttctc ggcggggcgg atgctcacct ggcgatcacc tgcctctcgt 180
tgacgatcga tcgtctatgc cgccgtctct gcgggaacag gccnccagta catcgccaca 240
gacgggatcc acccgcattt cggctacggt tgctcgtttc ggtgttcgga ctagtcggtc 300
ctggtgacgt gccggtgatg cggaccggtc ctagcactga ccaatggcca aaatgcgggc 360




130


483


DNA


Mycobacterium tuberculosis



130
cggggggcct cttaatagtg taggaaagaa gctctacata ttcaggagga ttcaccatgg 60
ctcgtgcggt cgggatcgac ctcgggacca ccaactccgt cgtctcggtt ctggaaggtg 120
gcgacccggt cgtcgtcgcc aactccgagg gctccaggac caccccgtca attgtcgcgt 180
tcgcccgcaa cggtgaggtg ctggtctgcc agcccgccaa gaaccaggca gtgaccaacg 240
tcgatcgcac cgtgcgctcg gtcaagcgac acatgggcag cgactggtcc atagagattg 300
acggcaagaa atacaccgcg ccggagatca gcgcccgcat tctgatgaag ctgaagcgcg 360
acgccgaggc ctacctcggt gaggacatta ccgacgcggt tatcacgacg cccgcctact 420
tcaatgacgc ccagcgtcag gccaccaagg acccggccag atcgccggtc tcacgtgctg 480
cgg 483




131


423


DNA


Mycobacterium tuberculosis



131
atactcaagc ttcataacag gcctgttgtg ggcgcacccg gctcgccgag ttctgcacgc 60
accgcctcaa gtgcggcccg caccgccggc atctcccggt cacgcagggc cgcggcccgc 120
gccgcagcga cggcgtgttc gcgcagttcg ccgtcaatga tgctgacctg atcggccacc 180
cgggcgttct cggcgtcttc gcgttcacta atcgcggtgc tcagcagcgt ctcgacagcc 240
accacccgag tggcgaccag ctgctccacc acggaccgca gcgatgccgt cacctcaccc 300
gtccagcggt ccaccacgac acggtcgtgc accagcgcgc gggcattcac cacccaggcg 360
gtcaccgcca ggccgatcgc cacacccgcc accatccccg atgcagccag gccgggagta 420
aga 423




132


338


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






132
ctggtgctgg acggagccta gtacaacttc ctctccaatg ctcttgcccc gatcgcggcg 60
accaggatga cccaggacat cctgccgccc gaagtactgg aaaagctcac acccgagttc 120
gtcgcaccgg tggtggccta cctgtgcacc gaggagtgtg ccgacaaccc atcggtgtac 180
gtcgtcagtg gtggttaggt gcagcgagtt gcgctgtttg gcaacgacgg cgccaacttc 240
gacaaaccgc cgtcngtaca agatgttgcg gcgcggtggg ccgagatcnc cgatctgtcc 300
ggtgcgaaaa ttgctggatt caagttgtag aactaaat 338




133


173


DNA


Mycobacterium tuberculosis



133
atactcaagc ttttccggcg tcgtccacct gacccaaaaa gcgcaggtgc gccgccaaac 60
ggcccgcctg gccgcgcaac tggtcggcgt cgccgtggcc gacaatcagt agctggacat 120
ccggaaaccg ctgcaccacc ttcggcagcg cgtcaagcaa aaacggccat tcc 173




134


255


DNA


Mycobacterium tuberculosis



134
tttcagatct catttttatg acatgactgg agatctgtct agattgcagc tcctgtgagc 60
gtgggtaccg gattcaagcc ggtcggtcac gccgcggtgg taccggcttt gcggcagtgc 120
tcggcctcga gttcggcgat cgcgcgcgaa gtgcgtttcg cgcaccaaga tcgcggccta 180
atggccggcg atgaccgcga tgaccagcgc gatccaggaa aaaccgttcc aaccagtgct 240
gggcggccat ccccg 255




135


285


DNA


Mycobacterium tuberculosis



135
atactcaagc ttcccgacca caagttgaac agcaccgatt tcggcgagca cttcgtcaac 60
ttccagggtg cccgcaccaa gtatttcgac aagtatttcc gtcgggccgc cgccgccggc 120
gcgcggcagg tggtcatcct ggcggcgggg ctggactccc gcgcgtaccg gctgccttgg 180
cccgacggga ccacggtttt tgagctggac cgcccgcagg tccttgattt caagcgcgag 240
gtgctcgcca gccacggtgc ccaaccgcgc gccctgcgcc cgcga 285




136


494


DNA


Mycobacterium tuberculosis



136
gtgtgctgtc aattcagagc tgagcctgat gcactcaact tactgagcat gctaacgctg 60
gtcgtgcggg tcttgttccc gcgtgtcggc agggcacacg ctcggggcgt agctgggaga 120
ggccccggtc aagcccggag agcagtgctc agtccgccag cttgaccgac tttcgatgag 180
aacgcgcttc tcgccgtatt gaactggcgt gctgacggtc gctgagcagc gctcgccgag 240
tgcggccgct gattctttca tcgagccagg aggcgcattc gtgttcggcc gcctgcgggt 300
cggccccatc gtcgacgcga tccgtcaccc actcctcgat caggtctgcc tcatcgaacg 360
ggccaacggt gctgtcggag tatgtgtgcg tgggcacggc gagccgggtg ctgtggtaca 420
cccaccgttg catgaccaag ttgacgcctg actggctgag caccgcgatc cgctcacagg 480
tcggaacgtt ggtg 494




137


357


DNA


Mycobacterium tuberculosis



137
atactcaagc ttttggtcta gccggccgag cccgatacag gtgtcattgg ccaccggcgg 60
cggctgtccg ggaaatggcg ggtccccggt ggttttgctg aggagtgctg aaccgtatgc 120
gaagtgggcg gcgtcagact ccacccagcc agcaggcagc gcgaaactga atcctccaac 180
cgggttgtcg atccggacag gttggggtgc gtttggggca atgacaggtg gcggcggtgc 240
gtccgggtcg gccggcggaa gtgctgcgtt gggatcgccc ggctgggcat tctgcgtgtt 300
ggcggcggcc ggtggtgggg gggcaacagg tgtctccggt gcgggtggcg ctgcacc 357




138


458


DNA


Mycobacterium tuberculosis



138
ggggccactc cgcacaatct gtacccgacc aagatctaca ccatcgaata cgacggcgtc 60
gccgactttc cgcggtaccc gctcaacttt gtgtcgaccc tcaacgccat tgccggcacc 120
tactacgtgc actccaacta cttcatcctg acgccggaac aaattgacgc agcggttccg 180
ctgaccaata cggtcggtcc cacgatgacc cagtactaca tcattcgcac ggagaacctg 240
ccgctgctag agccactgcg atcggtgccg atcgtgggga acccactggc gaacctggtt 300
caaccaaact tgaaggtgat tgttaacctg ggctacggcg acccggccta tggttattcg 360
acctcgccgc ccaatgttgc gactccgttc gggttgttcc cagaggtcag cccggtcgtc 420
atcgccgacg ctctcgtcgc cgggacccag cacggaat 458




139


595


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






139
ttctntcttc ccnnattcgt nnntctcnta ctaccngggc cncaaaacac cttggcnaac 60
gctcaaaggc gntacnggca ccaaggcccc acacgtcacc ctgtgacctc ctgcgccgac 120
cccgcccgag gtcctggccg ttaccactga acgggcgagc cgggagtctg gtacgcatcg 180
aacaaagagc aaggtgcatg ggcggagttg ttccgccnct ttttttatga cggggtcgat 240
ccattcgagg tccgtcgccg cgtcggtcga gtggcggtca cactccaggt actcgacctc 300
ncagacgaga ggactcgatc ccatctangt gtggacnaaa cagatcttct gtccgacgac 360
tacacaccac ccaggccatc gccgccgccc gcgatgccaa cttcnacncc gtnctggccc 420
cggcggcggc gctccccggt tgtcaaacac ctgccgtgtt cgttcacnca ctgcccaaca 480
tcnagcccga ncnatccnag gtccgtccaa cgcctccgcg gctcnccaac ctnctcccnc 540
tgatcntccg caccaaacac atgcccgact ccntgcnccn attgcttgna tccct 595




140


434


DNA


Mycobacterium tuberculosis



140
ccgctatcgg tcggtgtgct tggcggcgtc ggtatcaaca ccgcccacga aatggggcac 60
aagaaggatt cgctggagcg gtggctgtcc aagatcaccc tcgcccagac ctgctacggg 120
cacttctaca tcgagcacaa ccgtggccat cacgtccggg tgtccacacc ggaggacccg 180
gcgtcggcgc ggttcggcga gacgttgtgg gagttcctgc cccgcagtgt tatcggcggc 240
ttgcgctcgg ccgttcattt ggaggcccaa cggctgcgtc ggctcggcgt cagcccctgg 300
aatcccatga cgtatctgcg caacgacgtg ctcaacgcgt ggctgatgtc ggtggtgttg 360
tggggtgggc tgatcgcggt cttcggcccg gcgctgatcc cgttcgtcat catccaggca 420
gtcttcggct tcag 434




141


321


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






141
atactcatgc ttgccgaagt tccgatgggt cgcgccggcg ancccagcga agtcgctagc 60
gtggccgtgt tcttggcttc ggatctatcc tcgtacatga ccggcaccgt gttggacgtg 120
actggcggcc ggttcatatg acaccgagat cattgccacg gtacggcaat tcgtcaagaa 180
ggaaatcttt cccaatgcac cggccctcga acgtggcaac agctacccgc aagaaatcgt 240
cgatcggctg ggtgttattg gcttgctcgg tcgccggctg caagggtatc gacaccaccg 300
agttcattct ccgggcgtgc c 321




142


348


DNA


Mycobacterium tuberculosis



142
ggcgtcaacg gtgtcggcac cggcgtcctg cagttggtag gcctgcagtt tgtgcatcag 60
gccgatgccg cggccctcgt ggccacgcat gtacagcacc acgccgcgcc cctcacgggc 120
gaccatcgcc agcgcggcgt ccagctgagg cccgcaatcg cagcggcgtg acccaaacac 180
atcgccggtc aagcactccg aatgcacccg gaccagcacg tcgtcaccgt cggcgttggg 240
cccggcgatc tcgccgcgga ccagcgcgac atgttccacg tcctcgtaga tgctggtgta 300
gccgatggcg cgaatctccc atgacgagtc ggaatccgcg cctcggcg 348




143


339


DNA


Mycobacterium tuberculosis



143
atactcaagc ttcggcctcg ctgcaggagt gggagccgca gggctggaaa tccgaaaaac 60
gagccggtga tcgcactgtc gccgatcggg gccgcacctg gttggtgtta ccgatgaatc 120
cgcacccaaa atgtggctgc ggtggcgttt cttgactcct tggcgtcgac tcttgtggca 180
gccaccgagc ggttggtcca ggatctggat gggcaaagtt gtgcggcccg gccggtgacg 240
gccgatgagc tgaccgaggt cgacagcgcc gtgttggctg acttggaacc gacatggatt 300
cgccccggtt ggcgtcacct caagcatttc aatggttat 339




144


269


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






144
atgcgtcacc ccgatgcgcc cagatcgggg cttcgcaaat aaagcacgaa caggcgggca 60
aaacgtctat ctcggagccg gaagggcaat cagccgaccg tcgacgaacg acaccggcga 120
taaccactta ggcgttgaac ggccggccca aacattacgc ctccgttgat aaggctttcg 180
gtctcttccc cggtcatccc aagcaccttg cggcaaattt gaacgctttc ctgtccgggc 240
accggccccg ggctttgggg tccntccga 269




145


285


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






145
atactcaagc ttcaatcgcg ccgccacaat ccaaatatgc gtctagcgtc tcgatgagcg 60
tcggtccggc atcggctagg ggccgcatca cgtcggtatg cagggccacg atcgcccaag 120
gcgtcgccca tcaagggcgc gttcgggcaa aaattcccct atccagcacg ggccgcggcg 180
ctccgcncca gccggcgacg gcgttcatcc cggagatcgc ctcgctagcg ctgcggtgcg 240
ccgcggtcag catgggcgcc gtggggccga tgaccaccgg ggcgt 285




146


75


DNA


Mycobacterium tuberculosis



146
ttcggcgggt ctgtagattg cggtcggcca ccccacaggc actcatgaac cgcagcccac 60
gatcgatctc ggtgg 75




147


164


DNA


Mycobacterium tuberculosis



147
gcgcaccatc gccagtaggt gcccgtggtc gggcgcgtcg agccacccga gcggaaacgc 60
gagtccgaac agcaacagca ggacgggcgc aaccagggcg gtgaccatgc ccccggcgct 120
gaacatcaac cacaggaagg gctccgccga gcgtccgcgc gacc 164




148


228


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






148
catcgtcgaa cttcggtccg ggttgntagn accgcagcac caaacgcacc caccgacccc 60
cacgcttcac gccaaccctt tagttcattg gcgtgaacag cagcgtagcc ggttgccccg 120
atatatgtgg aaaaatcgtt cggacgtaca aaaaaagttc ctgacgctgg cgtcaactcg 180
aaactgcctc ggaagtcaat gatgatccat cagtcaatat taaagtcg 228




149


238


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






149
atactcaagc ttgtctgctg cctcagcgta tgcatccaac agcgcatcgc gatcaacgat 60
caggcgcgcc gatttcgggc cgcgggcagt ggcactggcc agatggccgt ttttttcgag 120
aaacttcaac gcctgagcgc tgcttcccat cgagagaccg gtggcctcta caaccgatgc 180
gacagttgga ccggcgatgt tcgccagcag cgcttcacat acggcaagtn tggcgcgg 238




150


162


DNA


Mycobacterium tuberculosis



150
ttgtccaggc ggggaatcgg gcagggagac gacaccttcg ttcggttcga tcgtcgcgaa 60
cgggtagttg gccgcgacca cgttgtttcg ggtcagcgcg ttgaaaagtg tcgacttgcc 120
gacgttgggc aggcccacga tccccaggct caagctcaca ga 162




151


377


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






151
atactcatgc ttggcgcctg ggtggcagcc cacctgccca ccacacggac cgcggtgcgg 60
acgcggctga cgcgcctggt ggtcagcatc gtggccggtc tgctgttgta tgccaacttc 120
ccgccgcgca actgctggtg ggcggcggtg gttgcgctcg cattgctggc ctgggtgctg 180
acccnccgcn cnacaacacc ggtgggtggg ctgggctacg gcctgctatt cggcctggtg 240
ttctacgtct cgttgttgcc gtggatcggc gagctggtgg gccccgggcc ctggttggca 300
ctggcgacga cgtncgcgct gttccccggc atcttcggtc tgttcgccgt cgtggtaccc 360
tgttgccggg ttggccc 377




152


308


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






152
cgccaattca cgatatcgtt aaccgatatc ccgagccgat agctggcggg ctcgggtggt 60
ggccagcggc gctgcgacga aaggtgtgac cgtcatgaaa cagacaccac cggcggccgt 120
cggccgtcgt cacctgctcg agatctcagc atccgcagcc ggtgtgatcg cgctttcggc 180
gtgtagtggg tcgccgcccg accccggcaa aggccggccc gacacaaccc cggaacagga 240
agtcccggtc accgcgcccg aagnacttga tgcgcgaacn cggagtgctc caaacgcatc 300
ctgctgat 308




153


377


DNA


Mycobacterium tuberculosis



153
atactcaagc ttgggcactg acttcggtac cccctccgcc tttggccagc agcagccaca 60
gcgcggttcg cggaccgaac gtggacatca atagcccgga atcggtgtgt gcaagttggt 120
aaacggtgtt gatcccaagc tttgccagcc ttttcgtagt cttgggcccc acaccccaca 180
gtgcttcgac ggtacggtca cccatgatgg ccatccagtt ggcatcggtg agctgataaa 240
tgccagctgg tttcgccaac ccggtagcga tcttggcgcg ctgcttgttg tcactgatac 300
ctatcgagca agacagcccg gtttgcgaca aaatgacttt tcggatctct tcggcgactt 360
cgatggggtc gtcggga 377




154


259


DNA


Mycobacterium tuberculosis



154
aaagtcctgt gccggttcgc taaacacccg gcggacactc agacggtgct ggtggtgcgg 60
catggcaccg cgggcagcaa agcgcacttc tccgggggac gacagcaagc gaccgctaga 120
caagaggggt cgtgcgcagg cagaaacgtt ggtacacagc tgctggcgtt cggcgccacc 180
gatgtttatg ccgccgaccg ggtgcgctgc caccagacga tggagccact cgccgcggaa 240
ctgaacgtga ccatacaca 259




155


372


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






155
atactcaagc ttgggttcca cgcccgcgca gccacgccgt cacctttcca cgagacctca 60
cctgccgatc cgaaatggaa tcggccgtga cggaattggc gcaccgaaca cccaacgagg 120
tggtggcttc gtcgcgaacc gtcacccgag tcgcggccac cgtgcgcacg gcgacgttct 180
acacccgcac caagatccga aagctgcaag ctcccagcac cgatcccgac gtcatcaccg 240
ctgccgcccg gcacgtcctt gacctattcg agctggatcg gcccgtccgg ttgctgggag 300
tgcggttaga actggcctag aaccggcggg cacaccgcnc ctgggcgggg cgaattcttg 360
accgcnccgg cc 372




156


290


DNA


Mycobacterium tuberculosis



156
cgcggttggc gtagttggac gggtcgccct ccgaggccaa tgatgacgat gaccacgccg 60
atcacgatgg ccaccgagag ggacaacaac agaaagctga cgaatccctc cttggcggcc 120
ggggctttgt ggtcgccggt cgcgatgggc gcgaatttac ggcccgctcc cccaggccgc 180
cgcgaagcag ggtccccagc cagttggcgt aggcggaatt aacgatcagc gccaccgcga 240
taacctgcca tgcctcgggc atatcgatgt gcggccagaa caggccgaac 290




157


470


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






157
ccaacaagag catcgggaca tacggagtca actacccggc caacggtgat ttcttggccg 60
ccgctgacgg cgcgaacgac gccagcgacc acattcagca gatggccagc gcgtgccggg 120
ccacgaggtt ggtgctcggc ggctactccc agggtgcggc cgtgatcgac atcgtcaccg 180
ccgcaccact gcccggcctc gggttcacgc agccgttgcc gcccgcagcg gacgatcaca 240
tcgccgcgat cgccctgttc gggaatccct cgggccgcgc tggcgggctg atgagcgccc 300
tgacccctca attcgggtcc aagaccatca ncctctgcaa caacggcgac ccgatttgtt 360
cngacggcaa ccggtggcga gcgcacctag gctacgtgcc cgggatgacc aaccaggcgg 420
cgcgtttcgt cgcgagcagg atctaaccgc gagccgccca tagattcccg 470




158


434


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






158
taanacccgt gtaatttggg atgggcaaaa aggccaagca ccgcgtggcc acgaacgccg 60
ggagggacaa tctcgggcgg ctagggcttc tcgcgggaag gcccgaacgt acggcgtttc 120
aacacgtcgc gtcnccctcc gaccgcgaac attcggggat ggcagcaacc tggtagcncc 180
ctggccgggc gatgatctgc agcgtcgccg cgggtagtcg ccgcccgggc ggctacagtc 240
tgaaacgcga tgaccatcga tgtgtggatg cagcatccga cgcaacggtt cctacacggc 300
gatatgttcg cctcgctgcg ccggtggacc ggtgggtcta tcccggagac cgacntcccg 360
atcgaagcga ccgtctcctc gatggacgcc ggcggcgtca ccctgggttt gctcaccgcc 420
tggcgtggcc ccaa 434




159


363


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






159
gtccgcaaaa gactcagcgg ccgactttgc tcgcagctgg cggtaccgcg ccaccgattc 60
gatgccgtgg tcgcggaaga atgcctcccg aaatcgcacg gccgactcca gttcggcgag 120
catccgcgat gccagctgcg gctgcgccct gccggccacg gcacccacat gcggcagttc 180
gtccacctgg gccagcgccc cgccgccgaa gtccaaacaa tagaactgca cccggcccgc 240
atcgtgggta gcagccaacg ccatgatcag cgtccgcagc gcggttgact tgcccgtttg 300
cggtgcacct acgaccgcga cattgcctgc ggccccggac aagtcgatcg tcagcggcac 360
ccn 363




160


301


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






160
cgtggccacg aacgccggga gggacantct cgggcggcta gggcttctcg cgggaaggcc 60
cgaacgtacg gcgtttcaac acgtcgcgtc gccctccgac cgcgaacatt cggggatggc 120
agcaacctgg cagctacctg gccgggcgat gatctgcagc gtcgccgcgg gtagtcgccg 180
cccgggcggc tacagtctga aacgcgatga ccatcgatgt gtggatgcat catccgacgc 240
aacggttcct acacggcgat atgttcncct cgctgcgccg gtggaccggt gggtctatcc 300
c 301




161


436


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






161
atactcaagc tttgcggcgg gcgccgaaat gtgaacgcac caaacccgcc cgctgcgggt 60
cggcgggcca ctcgacctcg aatttcgccg ccgtgaccat ccagcccgac ggcagttggg 120
cacccggccc cccggtcgcg gcataactgt tggcgtcgcc gtcataaagc tcgaacagca 180
ccgaaaccga ctccaccacc ggccggtgcg cctcaaaatc cacgccgatc tccacatacc 240
gggaaaacgt cggtgtccca tcgggtttcg gcttgcccgc cagctgcaca ccaccggtgg 300
cctcggccac cttcgcggcc tgagcgcagc tacncatcct gacgatcatc accccgcccc 360
cggctcacgc ttggcctccg tgaccgcacg catcgcccgg ttgcgcgcac cgcgacgccc 420
gtacagccgc gcgcac 436




162


390


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






162
agcttgccgg gactgcggaa cagaagcggc ggttcctacc gcggtgtgcg gccggcgcga 60
tatcggcctt tttactaacc gaacccgatg tgggctccga tccggcgcgc atggcatcga 120
cggcgacgcc gatcgatgac ggccaggctt acgagcttga gggtgtgaag ttgtggacca 180
ccaacggtgt ggtagcggac ctgctagtgg ttatggcgcg ggtaccgcgc agtgaagggc 240
accgaggggg aatcagcgcc tttgtcgtcg aggctgattc gcccgggatc accgtggagc 300
ggcgcaacaa gttcatggga ctgcgtggca tcnaaaacgg cgtgacccgg cttcatcgcg 360
tcngggtgcc caaagacaac ttgatcggca 390




163


75


DNA


Mycobacterium tuberculosis



163
ctcaagcttg gcgatgcggg ctggccaaaa ctggccgggc gggggttggc ttgttcaatc 60
aagggtgggt tgccg 75




164


110


DNA


Mycobacterium tuberculosis



164
ccgaaggccc gttcccgggc gttcagcaag cgatcgtcgg ttggcccact gcgggtcgaa 60
tcttgcggcc gcgccggtcg tggaacgccc aggtcacccg gcggcgtacc 110




165


455


DNA


Mycobacterium tuberculosis



165
atactcaagc ttttttctgc tcatgaaggt tagatgcctg ctgcttaagt aattcctctt 60
tatctgtaaa ggctttttga agtgcatcac ctgaccgggc aaatagttca ccggggtgag 120
aaaaaagagc aacaactgat ttaggcaatt tggcggtgtt gatacagcgg gtaataatct 180
tacgtgaaat attttccgca tcagccagcg cagaaatatt tccagcaaat tcattctgca 240
atcggcttgc ataacgctga ccacgttcat aagcacttgt tgggcgataa tcgttaccca 300
atctggataa tgcagccatc tgctcatcat ccagctcgcc aaccagaaca cgataatcac 360
tttcggtaag tgcagcagct ttacgacggc gactcccatc ggcaatttct atgacaccag 420
atactcttcg accgaacgcc ggtgtctgtt gacca 455




166


309


DNA


Mycobacterium tuberculosis



166
ctcaagcttg gtgccgacat ggccgggctg gagcccgcgt atggcaaggt tccgctcaat 60
gtggttgtga tgcagcagga ctacgttcgc ctcaatcagc tcaaacgtca cccccgtggc 120
gtgctgcgca gcatgaaggt cggcgcccgc acgatgtggg cgaaggcaac aggtaaaaac 180
ctggtcggca tgggtcgagc cctcattggg ccgttgcgga tcgggttgca ccgcgccgga 240
gtgccggtcg aactcaacac cgccttcacc gatcttttcg tcaaaaatgg cgtcgtgtcc 300
ggggtatac 309




167


232


DNA


Mycobacterium tuberculosis



167
ccgaagcgtg ggaaatcctg accgaatacc gcgacgtgct ggacactttg gccggcgagc 60
tgctggaaaa ggagaccctg caccgacccg agctggaaag catcttcgct gacgtctaaa 120
agcggccgcg gctcaccatg ttcgacgact tcggtggccg gatcccgtcg gacaaaccgc 180
ccatcaagac acccggggga gatcgcgatc gaaacgcggc gaaacttggg cc 232




168


455


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






168
cgactcgaca agcattcttg acagttgttt tggctcggca tggttagcca aggttctgcg 60
gtcccaccag atcatcttgg tccggtagcg ctcgtccggg tatgctgccg ccgggattct 120
cgctgctatt actccccccg aaaaacgcca ccggtccagc gcgtgggccg ccgcggtccc 180
catcacaaac tgaaccccca acaggggaca tgcttagcgg tagggcgcgc gccaaggcgg 240
cagcaatcgc atcactgcgc tgcgcgtcac tattaaccca cccggacttc acttccacga 300
ccccgaatgg cgcccggtca ttgatcatct tgcgcaccgc ggataatccg ggattgccag 360
cccattcgac taccgcatgc gagtcatcgg ctgaccgcag cggtccgatt acccgagcgc 420
cccgantaca tctcctccaa tatcaatggg cgcaa 455




169


428


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






169
gcggtntagc ttcccgtcgt accggcgacc gccagccgag aagctcgttt tcccagtgtt 60
gctggggatt ctcacgctgc tgctgagtgc gtgccagacc gcttccgctt cgggttacaa 120
cgagccgcgg ggctacgatc gtgcgacgct gaagttggtg ttctccatgg acttggggat 180
gtgcctgaac cggttcacct acgactccaa gctggcgccg tctcgtccgc aggtcgttgc 240
ttgcgatagc cgggaggccc ggatccgcaa tgacggattc catgccaacg ctccgagttg 300
catgcggatc gactacgaat tgatcaccca gaaccatcgg gcgtattact gcctgaagta 360
cctggtgcgg gtcggatact gctatccggc ggtgacgacc cccggcaagc cgccatccgt 420
gctgctgt 428




170


385


DNA


Mycobacterium tuberculosis



170
ctcaagcttg ggcgtgacgg ccaccggggc cactccgcac aatctgtacc cgaccaagat 60
ctacaccatc gaatacgacg gcgtcgccga ctttccgcgg tacccgctca actttgtgtc 120
gaccctcaac gccattgccg gcacctacta cgtgcactcc aactacttca tcctgacgcc 180
ggaacaaatt gacgcagcgg ttccgctgac caatacggtc ggtcccacga tgacccagta 240
ctacatcatt cgcacggaga acctgccgct gctaaagcca ctgcgatcgg tgccgatcgt 300
ggggaaccca ctggcgaacc tggttcaacc aaacttgaag gtgattgtta acctgggcta 360
cggcgacccg gcctatggtt attcc 385




171


318


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






171
cgggtgtcat tggccaccgg cggcggctgt ccgggaaatg gcgggtcccc ggtggttttg 60
ctgaggagtg ctgaaccgta gtcgaagtgg gcggcgtcag actccaccca gccagcaggc 120
agcgcgaagc tgaatcctcc aaccgggttg tcgatccgga caggttgggg tgcgtttggg 180
gcaatgacag gtggcggcgg tgcgttcggg tcggccggcg gaggtgctgc gttgggatcg 240
cccggctggg cattcggcgt gttggcggcg gccggtggtg ggggggcaac angtgtcgcc 300
ggtgcgggtg gcgctgca 318




172


443


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






172
ncttgatatt ggcgtcaacg gtgtcggcac cggcgtcctg cagttggtag gcctgcagtt 60
tgtgcatcag gccgatgccg cggccctcgt ggccacgcat gtacagcacc acgccgcgcc 120
cctcacgggc gaccatcgcc agcgcggcgt ccagctgagg cccgcaatcg cagcggcgtg 180
acccaaacac atcgccggtc aagcactccg aatgcacccg gaccagcacg tcgtcaccgt 240
cggcgttggg cccggcgatc tcgccgcgga ccagcgcgac atgttccacg tcctcgtaga 300
tgctggtgta gccgatggcg cgaaactccc catgacgagt cggaatccgc gcctcggcga 360
cccgctcaat gtgcttctcg tgcttgcgcc gccattcgat caagtcagca atggtgatca 420
gcgccagacc gtgctcntcg gcg 443




173


420


DNA


Mycobacterium tuberculosis



173
cataagggcc ggcgtacccg gtaccggccg cgggcctacc acgtgccgga actggaagcg 60
cagtaagccc tcaacgcgcc accgctttgg cccgcgcgcc cggcgtaggc gcatcggcgg 120
tggccgtggg gcggcgcact gcgacctcac cagcggcttt cgagctttgt tcgatcaacc 180
ggccagcatg gtcgaggatg cattcgagac catattcgaa attggtttca tcgggggccc 240
cgatccgatg ccccctccca gttgcgtgag caagcagcgg agtcgtcgcg ggatcgatgg 300
ccacggggtg ttcaatggcg gatggtccgc tgcccgccga ctggctcttg cgggagagcc 360
gatctagcac caccgatccg cgcacgtgga ccgaaaccgc cgagtagatg tcgaaagcgt 420




174


336


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






174
cgtccttttc cccaagatag aaaggcagga gagtgtcttc tgcatgaata tgaagatctg 60
gtacccatcc gtgatacatt gaggctgttc cctgggggtc gttaccttcc acnagcaaaa 120
cacgtagccc cttcagagcc nnatcctgag caanatgaac agaaactgag gttttgtaaa 180
cgccaccttt atgggcagca accccgatca ccggtggaaa tacgtcttca gcacgtcgca 240
atcgcgtacc aaacacatca cgcatatgat taatttgttc aattgtataa ccaacacgtt 300
gctcaacccg tcctcgaatt tccatatccg ggtgcg 336




175


264


DNA


Mycobacterium tuberculosis



175
ctcaagcttc atgtccgtac ggctcgggta cgcttccgtc gcagtgtgcg agtgataaat 60
gacgaccggg acctcgtcgg catcttccat agcccgccac accttcagtt gctcaccgga 120
atccaaccgg tagaaggtcg gcgagcgctc ggcattggtc atcgggatat gccgctcggg 180
acggtcagag ccctcgggtc cggccagcac tccgcaggct tcgtcggggt ggtcgcgaca 240
cgcatgggcc accatcgcat tcac 264




176


325


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






176
ncgccgccag ccaccacgcg cgggtcgggc gccgggcccg ggccgccagg ctgctccgct 60
cggtgatggc acgccaccgc gacaccaccc ggctgcgcta cgtcgagcca taccgggcgg 120
agctacatcg gctcggccgc ccagtgttcg ggccctcttt cgaggtcgag gtcgataccg 180
atttgcgcat ccgcagccgc accctggacg acagaaccgt gccctacgan tgcttgtcgg 240
gcggggccaa agaacagctt ggcatcctgg cgcgattggc cggcgcggcg ctggtctcca 300
aagaagacgc ccttccggtg ctgat 325




177


243


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






177
cgccacgttc atgggcaaca accccgatca ccggtggaaa tacgtcttca gcacgtcgca 60
atcgcgtacc aaacacatca cgcatatgat taattcgtcc aattgtataa ccaacacgtt 120
gctcaacccg tcctcgaatt tccatatccg ggtgcggtag tcgccctgct ttctcggcat 180
ctctgatagc ctgagaagaa accccaacta aatccgctgc ttcncctatt ctccagcgcc 240
ggg 243




178


430


DNA


Mycobacterium tuberculosis



178
atactcaagc ttcaaccgat tgacgcattg tgcgaactga cggcgcccgc gcatggccaa 60
tccggaagac catcattggc cagtggccgg gcgctaacag gttccagccc cccaccagtg 120
ccgctcgaac atgcggtgca acccattcgc aggccggcag ggaaagcacc gcggaagccg 180
caaagggctg cagttccgcg cccaatagtg tcgtccgcaa ccagatgcgc tcgaaaaccg 240
cgccggcagt cagcgcaccc gacgcgaggt cgagagacgt cgtcagcgcg cccacatggg 300
gtgccaatcg gcacggcagg taggccgcgc gcaacccgaa cgcgtggtgc atgcccacgg 360
tccgcaggag gcgcagcacc cgccaatgcc gaagcccacg aaacatcggg cgcatccacg 420
cttcaacctc 430




179


448


DNA


Mycobacterium tuberculosis



179
agcttttggc agggtctcct tcgaattcgg cgtgcaccgc tatgggttgc agcagcggct 60
ggcgccgcac accccactgg cccgggtgtt ttcgccccga acccggatca tggtgagcga 120
aaaggagatt cgcctgttcg atgctgggat tcgccaccgc gaggccatcg accgattact 180
cgccaccggg gtgcgagagg tgccgcagtc ccgctccgtc gacgtctccg acgatccatc 240
cggcttccgc cgtcgggtgg cggtagccgt cgatgaaatc gctgccggcc gctaccacaa 300
ggtgattctg tcccgttgtg tcgaagtgcc tttcgcgatc gactttccgt tgacctaccg 360
gctggggcgt cggcacaaca ccccggtgag gtcgtttttg ttgcagttgg gcggaatccg 420
tgctctgggt tacagcccga atcgtcac 448




180


380


DNA


Mycobacterium tuberculosis



180
atactcaagc tttgtcacac caactgtttc caccaggcgc tccatccggc gagtggatac 60
tcccagcagg tagcaggtcg ccaccacgct ggtcagtgcg cgttcagctc gcttgcggcg 120
ctgcagcagc cagtccggga aatagctgcc ctggcgcagc ttggggatcg cgacttctat 180
ggttgcggca cgggtgtcga aatcacggtg gcggtagccg ttgcgctgat tggaccgctc 240
atcgctgcgt tcgcggtagc ccgccccgca cagggcgtcg gcttcagccc ccatcaaggc 300
ggcgatgaac gtcgagagca gcccgcgcag cagatccggg ctcgcctgtg cgagttggtc 360
agccagaacc tgctcggtgt 380




181


532


DNA


Mycobacterium tuberculosis



181
ccttaagccc cgcagggccc ggcacgcgcg gtaccgccca ggtcgcccaa cagatcgtcg 60
atgttcgcgt cgtccgcctc gcgcacgtgg tctgtcacca gtcaacgtta acgccgccgc 120
acatgtcctg cggccgggca aaaacgtgaa aaacgagcgg gcgactgcaa tgtcatgaca 180
ccgacggccg ccgatgggcc cagggtctgg cagattcgat ctgtgcggcc agtgccagca 240
gcgtcgcctc gtcatacggc cggccgacga gttgaaccga catgggcagg ccgtcgccgt 300
cgaagtccca cggcaccacg gccgcgggct ggccggtcag attccagact tgaaagtacg 360
gaacccgctg caccaccagc agcaacgtcg aaactgcacc ccggcgttgg taggcgccga 420
tgcgggacgg gccggtcgcg gcgcctggcg tcacaactac gtcgacatcg tcgaagatcg 480
actggatcgg ctgctcacac cactcggcgg ccgcaggccg ccatccgccg tc 532




182


477


DNA


Mycobacterium tuberculosis



182
agctttttga gcgtcgcgcg gggcagcttc gccggcaatt ctactagcga gaagtctggc 60
ccgatacgga tctgaccgaa gtcgctgcgg tgcagcccac cctcattggc gatggcgccg 120
acgatggcgc ctggaccgat cttgtgccgc ttgccgacgg cgacgcggtg ggtggtcaag 180
tccggtctac gcttgggcct ttgcggacgg tcccgacgct ggtcgcggtt gcgccgcgaa 240
agcggcgggt cgggtgccat caggaatgcc tcaccgccgc ggcactgcac ggccagtgcc 300
gcggcgatgt cagccatcgg gacatcatgc tcgcgttcat actcctcgac cagtcggcgg 360
aacagctcga ttcccggacc gcccagcgca ttggtgatgg aatcggcgaa cttggccacc 420
cgctgggtgt tgacatcctc gacggtgggc aattgccccc ggtaacgttt gccgcct 477




183


461


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






183
cggtccgacc ctgttcgacg gctacctgaa tcaacccgat gccaccgccg cggcgttcga 60
cgccgacagc tggtaccgca ccggcgacgt cgcggtggtc gacggcagtg ggatgcaccg 120
catcgtggga cgcgagtcgg tcgacttgat caagtcgggt ggataccggg tcggcgccgg 180
tgaaattgaa acggtgctgc tcgggcatcc ggacgtggcg gaggcggcag tcgtcggggt 240
gcccgacgat gatctaggcc agcggatcgt tgcctacgta gtcggctcag cgaatgtcga 300
tgcggacggg cttatcaact ttgttgccca acaactttcg gtgcacaagc gcccgcgcga 360
ggtgcgtatc gtanatgcgc tgccgcgcaa cgccttgggg aaagtgctcc agaacattgc 420
tgtcagaagc tganctacgc gaattatcgt gttacgctgg a 461




184


440


DNA


Mycobacterium tuberculosis



184
atactcaagc ttgccgaagt tccgatgggt cgcgccggcg agcccagcga agtcgctacc 60
gtggccgtgt tcttggcttc ggatctatcc tcgttcatga ccggcaccgt gttggacgtg 120
actggcggcc ggtccatatg acaccgagat cattgccacg gtacggcaat tcgtcaagaa 180
ggaaatcttt cccaatgcac cggccctcga acgtggcaac agctacccgc aagaaatcgt 240
cgatcggctg ggtgttattg gcttgctcgg tcgccggctg caagggtatc gacaccaccg 300
agttcattct cgggcgtgcc ggcgcattcg agctggcggt gcgcgctgcc cagcaccgtc 360
ataggtactt gacgatggtc cacgtcggac gagcgcctcc acgtcgctgc cgaacggtat 420
gcatggcggc tacgattctc 440




185


515


DNA


Mycobacterium tuberculosis



185
cggtgtcggc accggcgtcc tgcagttggt aggcctgcag tttgtgcatc aggccgatgc 60
cgcggccctc gtggccacgc atgtacagca ccacgccgcg cccctcacgg gcgaccatcg 120
ccagcgcggc gtccagctga ggcccgcaat cgcagcggcg tgacccaaac acatcgccgg 180
tcaagcactc cgaatgcacc cggaccagca cgtcgtcacc gtcggcgttg ggcccggcga 240
tctcgccgcg gaccagcgcg acatgttcca cgtcctcgta gatgctggtg tagccgatgg 300
cgcgaaactc cccatgacga gtcggaatcc gcgcctcggc gacccgctca atgtgcttct 360
cgtgcttgcg ccgccattcg atcaagtcag caatggtgat cagcgccaga ccgtgctcat 420
cggcgaacac cgcaattcat cggtgttgcg ccatcgagcc ctcatctttt tggctgacga 480
tctcgcaaat cgcccccgcg ggttgcagcc ggcat 515




186


345


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






186
atactcaagc tttgggtgaa agccgatcac cggaagccgc atgatcagcc acgtttcgcg 60
ccgcccggca tacggcggcg taccgatctc cgcgtcatac acccgcgggt aatcgccgac 120
ggtgccggtt cgcgagccga aggtgacgac gctgattgaa tcgagttcca ggtccagcgg 180
gtggcgcagc aacggcgcga gctcaacgac gtcaatcacg ttgtcgcttt ctacggtcac 240
cgacccggtg accgtnctcg cccggtgcgc tcggccgata agttgcaccg ccaccaccgc 300
gacaccgtct tgcacgcgga cccacccccg gatccgttgt tggcc 345




187


366


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






187
agcttgctgg catccgctcc agtagcgccc cgcgcgtggc ttccagcgcc cgcagatgct 60
ccatgagccg gccggtcgag tcggcgccgg cgttcaccgc cacccgccag gagctggcgg 120
ccagcatctc cgccttcacg cattgcgcga tcacagagag aatatacgtc tcatattcgt 180
tggaggtcgt cgcaggcaat cggtcgatga cggatttgat ggcatcgagc tgtgcttcgg 240
cgtagccctc cagcacgtcg gtatcgctgt ggcggtccac gacgaccgca ccggcgcggc 300
ggacagccgt cgggttggac gntgtgcggc gatcagtccg gccagctccg cctcgggatc 360
agcggc 366




188


423


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






188
atactcaagc ttgctgcagc ttcctatgac tgctcccgaa acctgggggt gtgcctgctg 60
tgtatgcacg gcatacggac atccttcccc tgagacccgc ggtcgaacca gccacgtgtc 120
catcatcagg ggtcaacccc ggccaagggc gacggcacgc caagttcgcc gaccgttaac 180
ctagtgctgt tagcttcatt tgctgcgagc aaaacagctg gtcggccgtt aggaactgaa 240
ttgaaactca accgatttgg tgccgccgta ggtgtcctgg ctgcgggtgc gctggtgttg 300
tccgcgtgtg gtaacnacna caatgtgacc gggggaggtg caaccactgg ccaggcgtcg 360
gcgaaggtcg attgcggggg gaagaagaac tcaaagccag tgggtcgacg cgcaggccaa 420
cgc 423




189


453


DNA


Mycobacterium tuberculosis



189
agcttgacgc ggagacggac acattgcgaa cattgatgac aaaatagaaa tcattgatgg 60
tttgagtcac caggccgatc aagccttcgc cgagccaaat tccaatcaag aggcccaagc 120
ccgtaccaat cagcccggca acgagggatt ccgtcattat cagccaaaat aactgctctc 180
gggttacacc caaacagcgc aatatggcga aaaacggtcg ccgttgcacg acattaaatg 240
tcacggtatt gtagattaaa aagataccca ccaacaaggc aatcaaactg agagcggtta 300
aattgaccgt aaaagcgtcc gtcatctgtt tgacggtgtc ccgttgggta tccgacgttt 360
ccatacgcac accggccggc agtctttgtt ggatgcgtgt tgcagtggcc tcatctttga 420
tgatcaaatc gatgtggctc agtcttccgg gca 453




190


402


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






190
atactcaagc ttcggctcag gcggcgctgc tggtaaagtc gctgaccggt gcaggtttcg 60
acaatgtggt gccggttcgg cggctacgtg ccatcgagac actggcgcag gctatcgcac 120
ccgttatcgg ctacgagcaa atcgcggtat gcgttcttga gcatgagtcg gcgaccgtcg 180
tcatggtcga cacccacgac ggaaagacgc agatcgccgt caagcatgtg tgccgcggat 240
tatcaggact gacctcctgg ctgaccggca tgtttggtcg cgatgcctgg cgcccggccg 300
gcgtggtcgt ggtccgctcg gatagcgagg tcagcgaatt cncntggcag ctccaaaggg 360
tcctgccggt gccggtcttt gcgcaaacna aggcncaggt ta 402




191


427


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






191
tgatcgcgca tcacctgctt cataaactgg aagcagcgca gcgcttcctt ttcggccgca 60
acatgagcca gcctctcgtc ggcggtcggg tgcaggtgct cgggcagctc ggccgcgaca 120
gccgcctgac cctgaaacca gcttccatat cccgcgacga acgacgccag tccgctacgt 180
aacccctccg cgactgtcca tggacaacag cgcgttctcc accgaccggg cccgggtgtg 240
gggtgtttcg gcgaccggca gccaggtggt ccacactgcc gacgggcgcc gcgagccgtt 300
caccgaccag gccgccgagc aagtccgccc gatcgcatac tccaaccggt tgcggtactg 360
caggttcagc tggcgtactc ctcgtcgcgc tcggcgaggt cttgctccag cacgtcgcan 420
acggcag 427




192


347


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






192
caaagcgcga actgctcgcg gcagcccacg acgtgctgcg tcggattgcc ggcggcgaaa 60
tcaattccag gcagctcccg gacaatgcgg ctctgctggc ccgcaacgaa ggactcgagg 120
tcaccccggt gcccggggtc gtggtgcacc tgccgatcgc acaggttggc ccacaaccgg 180
ccgcttgatg cccggtcggc aagcccggca gttgccaaac ccagcgtgat caggctcggc 240
tcgcgagttc cgggaagaag tggctccgcc tgatcaccta ccatccgcca ggatctgcgt 300
gtcttcacca cgcccgccaa ggaggttgtt gtggtgctat cgaccgn 347




193


330


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






193
ccggaagccg catgatcagc caagtttcgc gccgcccggc atacggcggc gtaccgatct 60
ccgcgtcata cacccgcggg taatcgccga cggtgccggt tcgcgagccg aaggtgacga 120
cgctgattga atcgagttcc aggtccagcg ggtggcgcag caacggcgcg agctcaacga 180
cgtcaatcac gttgtcgctt tctacggtca ccgacccggt gaccgtngtc gcccggtgcg 240
ctcggccgaa aanttgcacc gccaccaccg cgaaaccgtc ttgcacnccg gaagccaccc 300
ccgatccgtt gttgggccag gttattgggt 330




194


215


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






194
ccggaaccgc cgacggcacg gtataacgcc tccgcatatg ggtcgacaac cagcgggtcg 60
gacttctggg cttctagcgt tcgcgcngtc gcgacaaaca gcgcggtcga accgacactc 120
gttgtgatgt cctagctatc acgttcggta cgcacccaat cgagtctagc gcgggtagnt 180
cagccccgat ctccangctc cgccgagcca ggcgc 215




195


225


DNA


Mycobacterium tuberculosis



195
ctggtttatg tcccgttgaa gttccatcac ccgatgtggc gggagcactg ccaggtcgat 60
ctcaactacc acatccggcc gtggcggttg cgcgccccgg ggggtcggcg cgaactcgac 120
gaggcggtcg gagaaatcgc cagcaccccg ctgaaccgcg accacccgct gtgggagatg 180
tacttcgttg aggggcttgc caaccaccgg atcgcggtgg ttgcc 225




196


161


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






196
ccgagcagtt gggaatcgct ctgcancaaa ccaatattct gcgcgacgtc gcgcgacgag 60
ctggaccgat taggcgtacg cctccgnctg gacgacaccg gggcactcga tgaccccgac 120
gcctacgctc gcaggatatt gttcgccgga cccctctcta g 161




197


240


DNA


Mycobacterium tuberculosis



197
tatataatac tcaagcttgc cgacgccaac gctcgcgcga tgttgttagc ccgacccggc 60
tcttacatgg caccggtgcc ccacacgtca gcctgtgacg tcctgcaccg cgactcttta 120
catagaatgt ggattgccgg attggggatg tccggcatcg ctcaatctgt agtccgcgtt 180
gtcccgcgag ggccatgtgg atggggggaa ggatccgtgg cgtccgggat caccatgggg 240




198


348


DNA


Mycobacterium tuberculosis



198
atactcaagc ttgccgaagt tccgatgggt cgcgccggcg agcccaacga aatcgctagc 60
gtggccgtgt tcttggcttc ggatctatcc tcgtacatga ccggcaccgt gttggacgtg 120
actggcggcc ggttcatatg acaccgagat cattgccacg gtacggaaat tcgtccagaa 180
ggaaatcttt cccaatgcac cggccctcga acgtggcaac agctacccgc aagaaatcgt 240
caatcggctg ggtgttattg gcttgctcgg tcgccggctg cgagggtttc tacaccaccg 300
agttcattct cgggcgtgcc ggcgcattcg aactggcggt gcgcgctg 348




199


371


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






199
gcaccggcgt cctgcagttg gtaggcctgc agtttgtgca tcaggccgat gccgcggccc 60
tcgtggccac gcatgtacag caccacgccg cgcccctcac gggcgaccat cgccagcgcg 120
gcgtccagct gaggcccgca atcgcagcgg cgtgacccaa acacatcgcc ggtcaagcac 180
tccgaatgca cccggaccag cacgtcttca ccgtcggcgt tgggcccggc gatctcgccg 240
cggaccaacg cgacatgttc cacgtcctcg tagatgctgg tgtagccgat ggcgcgaaac 300
tccccangac aagtcggaat ccgcgcctcg gcgaaccgct caatgtgcct ctcgtgcttg 360
cgccgccatt c 371




200


165


DNA


Mycobacterium tuberculosis



200
tggtccgtgt gcgcatacca atacaacgcg ccgggcacct gacgcggcgg ccgcaaccaa 60
tcggtggcca tcgccatctt ctgctacccg gtcaacggac gcaccttctc ctggccgacg 120
tagtgcgccc acccgccgcc gttgcgtccc atcgatccgg tcaac 165




201


390


DNA


Mycobacterium tuberculosis



201
ggcgtgttgg ccaccggggc cactccgcac aatctgtacc cgaccaagat ctacaccatc 60
gaatacgacg gcgtcgccga ctttccgcgg tacccgctca actttgtgtc gaccctcaac 120
gccattgccg gcacctacta cgtgcactcc aactacttca tcctgacgcc ggaacaaatt 180
gacgcagcgg ttccgctgac caatacggtc ggtcccacga tgacccagta ctacatcatt 240
cgcacggaga acctgccgct gctaaagcca ctggcgatcg gtgccgatcg tggggaaccc 300
actggcgaac ctggttcaac caaacttgaa ggtgattgtt tacctgggct acggcgaccc 360
ggcctatggt tattcgacct ccccgcccaa 390




202


427


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






202
cgtccgtgnc ccctcaancg cgtgnngccg aagcggctgg ttacgactcc ctgtttgtga 60
tggacacttc taccaactgc ccatgttggg gacgcccgac cagccgatgc tggaggccta 120
cacggccctt ggtgcgctgg ccacggcgac cgancggctg caactgggcg cgttggtgac 180
cggcaatacc taccgcagcc cgaccctgct ggcaaagatc atcaccacgc tcgacgtggt 240
tagcgccggt cgagcgatcc tcggcattgg agccggttgg tttgagctgg aaacaccgcc 300
agctcggctt cgagttcggc actttcagtg accggttcaa ccggctcgaa gaggcgctac 360
agatcctcca gccaatggtc aagggtgagc gcccaacgtt tttcggcgat tggtacacca 420
ccgaatc 427




203


498


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






203
ccgcttccgt gtaaccgagc anngcgagcg anctggcgag gaagcaaaga agaactgttc 60
tgtcagatag ctcttacgct cagcgcaaga agaaatatcc accgtgggaa aaactccagg 120
tagaggtaca cacgcggata gccaattcag agtaataaac tgtgataatc aaccctcatc 180
aatgatgacg aactatcccc cgatatcagg tcacatgacg aagggaaaga gaaggaaatc 240
aactgtgaca aactgccctc aaatttggct tccttaaaaa ttacagttca aaaagtatga 300
gaaaatccat gcaggctgaa ggaaacagca aaactgtgac aaattaccct cagtaggtca 360
gaacaaatgt gacgaaccnc cctcaaatct gtgacagata accctcagac tatcctgtcg 420
tcatggaagt gatatcgcgg aaggaaaata cgatntgagt cgtctggcgg cctttctttt 480
tctcaatgta tgagagcg 498




204


265


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






204
tgacacccaa cagagggcac ttaagatggc aatgcggccg cctacctgca cgttttcgcg 60
atgtcagagg atgccgaggg agaacaatgc gagcacggcc gctgacnttg ctcaccgctt 120
tggcggcggt gacattggtg gtggttgcgg gctgcnaggc ccgantcnag gccgaagcat 180
atagcgcggc cgaccgcatt tcgtctcgac cgcaagcgcg acctcagccg cagccggtgg 240
agctactgct gcgcgccatc acgcc 265




205


369


DNA


Mycobacterium tuberculosis



205
acgggcgacg ctgaggtggg cccgcggcta ttcatgctgt cgtccacgtc cagcgacgca 60
ctgcgccaga cggcccgcca actagccacc tgggtggaag aacaccagga ctgcgtggcg 120
gcctcggatc tggcctacac gctggcgcgt ggccgcgcgc accggccggt gcgcaccgcg 180
gtggttgccg ccaacctgcc ggagctcgtc gagggtttgc gcgaggtggc cgacggtgac 240
ccctctatga cgcggcggtg ggacactgtg atctaagacc ggtctgggtc ttctccgggc 300
aagggtctca gtgggcggcg atgggcaccc aattgctcgc cagcgaacca gtgttcgcgg 360
ccaccatcg 369




206


428


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






206
atactcaagc ttcgcgagat ccggatggca ctcacgctgg acaagacctt cacaaaatct 60
gaaatcctga cccgatactt gaacctggtc tcgttcggca ataactcgtt cggcgtgcag 120
gacgcggcgc aaacgtactt cggcatcaac gcgtccgacc tgaattggca gcaagcggcg 180
ctgctggccg gcatggtgca atcgaccagc acgctcaacc cgtacaccaa ccccgacggc 240
gcgctggccc ggcggaacgt ggtcctcgac accatgatcn aaaacttccc ggggaggcgg 300
aggcgttgcg tgccgcccag ggcgaaccgc tgggggttct gccgcagccc aatgattgcc 360
gcgcggctgc atcgcgggcg gcgaccgcca ttcttctgcg aatacgtcca ggagtactgt 420
ctcggggc 428




207


378


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






207
agcttatgtg gccgcccacc taccttatct agcctagcta actaaatcca gtgccgacag 60
tgcgcggctg gccacccagc atgaggttat gaccacggca tatgccagcg cgctggcggc 120
gatgccgacg ctgaccgagt tggccgctaa tcacaccagc catgcggtgt tgctgggaac 180
gaatttcttt ggaatcaata cgatcccgat cgcgctcaat gaggccgact atgcgcggat 240
gtggattcag gcggccacca cgatgagtat ctatgagggc acctccgatg cggcgctggc 300
gtcngcaccg caaaccacac cggctccggt actgttcaac ggcggtgctg gcgtttgcca 360
gcgcctgccg gcgatctc 378




208


284


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






208
atactcaagc ttgccaccca tgccgagcaa ggtcgactca gcgatgacga attgttcttc 60
ttcgcggtgt tgctgctggt tgcgggctat gagagcactg ctcatatgat tagcacnttg 120
tttctgacgc tggccgacta tccagatcag ctgacactcc ttgcgcagca accagacctg 180
atcccgtcgg cgatcgagga gcacctccgc tttatatcgc aatccaaaac atctgccgca 240
caacgcgcgt cgactattcg gtcggtcaag cggtcatccc ggga 284




209


236


DNA


Mycobacterium tuberculosis



209
ccggggtaga acgatgcgat ctgggccatg tcgacatcgg tggtacaggt aaaccgcgcc 60
gtgtgcgcgg tctcggagat cagaacgtgg tcgcagttga caccgcgggc tttcagccag 120
tcgcgataat cggcgaagtc ggcgcctgcc gccccaacta gcgcgacctc gccacctagc 180
acaccgatgg cgaaggccat gtttccggcc acgccgccgc ggtgcatcat caactc 236




210


278


DNA


Mycobacterium tuberculosis



210
atactcaagc ttggcggcaa cgccactacc gggctcacca ggtcctgtgc cgccaccgcc 60
ggcgccgaaa gcaccatcag gtcgtagttg tctggacgtt cgacaccgta agcgaacaca 120
atgccgccgc ccatgctgtg cccgagcacg atgcgcttgc acccgggata ttcccgggtg 180
gcgatcccaa cgagggtgtc gaagtcagcg gtgtatctga gatgtctctc actatcatcc 240
gtttggcacc cgagcgggca tgcccgcggg gggtcaac 278




211


360


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






211
gtcgacggca tcaaggtccg cagtgatggt gttcatctca cccaggaagg cgtgaagtgg 60
ctgataccgt ggcttgagga ttcggtgcgg gtcgccagtt aatccgccgt gtgctccgga 120
tgagcgcgac ggtaaccctg gaattgtgct gtgtgctggc tgtgtcgttg tgatgagcct 180
gtctaagtgg tgcgtaaccg tttgacgagc cgcggcctcg ctgcaaacat tgaagcccgc 240
acgtctgggt ttgtatttac acaacgaggg cgctccccga tctggcgcgc gcaacgaggt 300
gcncactatc cattcgaggt gaactggact ccttgatgct catgccggtg cggttttgtc 360




212


256


DNA


Mycobacterium tuberculosis



212
atactcaagc ttgcgttcga tgaagtagtc gtcggtcagc gccgcctctt cgagctcctt 60
ggcgatgccc agcaaggagt catcgccgcc gagcttggcc aggatcttgt cggcctgttc 120
cttgacgatg cgggcccgcg gatcgtagtt cttgtagaca cgatgaccga aacccatcaa 180
tttgaccccg gcctcgcggt tcttgacctt gcgttacaaa ctcgctgacg tcgtcgccgc 240
tgtcgcgaat gccctc 256




213


262


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






213
ngtcaagccg agcatgcgcg aggnaacgac gaacccaaca agccatggtg gttggcgccg 60
tcgagaggtc ggcggtcgcc acaacgggaa gatcgccttg agcgtcgctc gaccgccgcc 120
tcgagttggg tcataacgaa gtagctgatg ccgatcatgt cgacgtttcc gtcgcatcag 180
cgtgcagcgg cgacccactc gacgaggtct cggtgccgcc gcggccaggg caccagcagt 240
gacgattcca ggcgccgtcg gg 262




214


336


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






214
cgataatcgc ttccggtaag tgcagcagct ttacgacggc gactcccatc ggcaatttct 60
atgacaccag atactcttcg accgaacgcc ggtgtctgtt gaccagtcag tagaaaagaa 120
gggatgagat ctccccgtgc gtcctcagta agcagctcct ggtcgcgttc attacctgac 180
catacccgag aggtcttctc aacactatca ccccggagca cttctagagt aaacttccca 240
tcccgaccac atataggcta aggtaatggg cattaccgcg agccattact cctacgcgcg 300
caattaacga atccaccatc ggggccgctg gtgtcn 336




215


259


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






215
naatactcaa gctttctcgt gattaccacc cgtgtaattt gggatgggca aaaaggcgaa 60
tcaccgcgtg gccacaaacg ccgggaggga caatctcggg cggctagggc ttctcgcggg 120
aaggcccgaa cgtacggcgt ttcaacacgt cgcgtcgccc tccgaccgcg aacattcggg 180
gatggcagca acctggtatc accctggccg ggcaatgatc tgcagcgtcg ccgcgggtag 240
tgnccgcccg ggcggctac 259




216


325


DNA


Mycobacterium tuberculosis



216
ccaactagag catcgggaca tacggagtca actacccggc caacggtgat ttcttggccg 60
ccgctgacgg cgcgaacgac gccagcgacc acattcagca gatggccagc gcgtgccggg 120
ccacgatgtt ggtgctcggc ggctactccc agggtgcggc cgtgatcgac atcgtcaccg 180
ccgcaccact gcccggtctc gggttcacgc agccgttgcc gcccgcagcg gacgatcaca 240
tcgccgcgat cgccctgttc gggaatccct cggggccgcg ctggcgggct gatgatcgcc 300
ctgacccctc aattcgggtc caaga 325




217


300


DNA


Mycobacterium tuberculosis



217
atactcaagc ttgctgcagc ttcctgtgac tgctcccgaa acctgggggt gtgcctgctg 60
tgtatgcacg gcatacggac atccttcccc tgagacccgc ggtcgaacca gccacgtgtc 120
catcatcagg ggtcaacccc ggccaagggc gacggcacgc caagttcgcc gaccgttaac 180
ctagtgctgt tagcttcatt tgctgcgagc aaaacagctg gtcggccgtt aggaactgaa 240
ttgaaactca accgatttgg tgccgcccgt aagtgtcctg gctgccggtg cgctggtgtt 300




218


265


DNA


Mycobacterium tuberculosis



218
agcttgcgcg gcgtggcgat cgcggttcaa ggcgcgctct tcgagcacaa cgagcgaaga 60
cagctcggcg acggagcctt tatcgacatc cgttcgggct ggctgaccgg cggcgaagaa 120
ctgctggacg cgttgttgtc gacggtgccg tggcgagccg agcgccgtca gatgtacgac 180
cgggtggtcg atgtgccgcg gctggtgagt tttcacgacc tgaccatcga agatccgccg 240
catccgcagc tggcgcggat gcgcc 265




219


362


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






219
aatactcaag cttgcgcacg accaggacgt cgagtggcgc ttgcagtgac ttggcgacct 60
caaaggccac cggtaccccg ccgcgcggca agccaaggac nacnacggcc ttgccggata 120
gctgcgccag gcgttgcgcc aactggcgtc cagcgtcgcc acgatcgtca aagagcttca 180
tctgccgagt gtgtcgccat ctcatggctc caaatatgga attaggtccc tgggccgact 240
gacgacagtc cctcagcgac cggattgcgc atcccgcctt gtacgctgct ccgcaaatcc 300
cgggcttgcg tccgcggaag cgaactcggc ggcgctacgg tggtggctca cttcggccgt 360
gc 362




220


486


DNA


Mycobacterium tuberculosis



220
ggttggtgcg gtccaccttc gcggcggcgg cgcgatatgc cttgctggtc ttgctcattt 60
gatatccaat ctatgggtcg tggttactca gcgggccgaa gctggccctc ccacgggtag 120
ggccctattc gacggtgatg cccatcgacc gagcggtacc ggcgatgatc ttggccgcag 180
cgtcgacgtc gttggcgttg aggtccgtct tcttggtctc ggcgatttcg cggacttgat 240
cccaggtgac tttggcgacc ttggtcttgt gcggctccgc cgaacccttc gccacaccag 300
cggccttaag cagcagcttg gcggcgggcg gcgtcttcag cgtgaaagtg aagctacggt 360
cttcataaac ggtgatctcc accgggatga cgttgccgcg ctggttctcc gtcgcggcgt 420
tgtacgcctt gcagaactcc atgatgttga cccgtgctga ccgaacgcgg ggcccactgg 480
cggggc 486




221


373


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






221
atactcaagc ttttcgaccc gcaagccggc ggtgcccctc ctcgttccgc tgcccggtct 60
gctcgatcgg ttcggggtcg ccgcgctagg cccaattgcc cggctcctcc tcgggccgtt 120
ccacaacccg catcgtcgcc gggctaggtt caagccatgc cggtaaaccc caggacgcca 180
gtgctgatcg gctatggaca ggtcaaccac cgaggcgaca tcgacgccna aaatcagtcc 240
atcgaacccg tcgacctgat ggccnccgcg gcccggaaag ccgccgagtc caccgtgctc 300
gaagcggtgg attccatccg tgtggtgcac atgctgtcgg cgcattaccg gaattcccgg 360
gcgtctcctc ggc 373




222


331


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






222
ncctggttca tgaactggaa gcagcgcagc gcttcctttt cggccgcaac atgagccagc 60
ctctcgtcgg cggtcgggtg caggtgctcg ggcagctcgg ccgcgacagc cgcctgaccc 120
tgaaaccagc ttccatatcc cgcgacgaac gacgccagtc cgctacgtaa cccctccgcg 180
actgtccatg gacaacagcg cgttctccac cgaccggggc cgggtgttgg ggtgttcggc 240
aacggcaacc aagttggtcc acactgccga cgggcgccgc aaatccgttc accgaaccag 300
gccgccnaaa caattccgcc cgatcccata t 331




223


377


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






223
atactcaagc ttgtcgggat caatctcgag ggcatccacg cacgaaaagt aaactctatc 60
aagctttttg acgacaccca cggacgcccc atatatgttc gggtgggcaa gaacggtccc 120
tacctggaac gtttggtggc cggcgacacc ggtgagccca cgccgcagcg ggccaacctc 180
agcgactcga ttaccccgga cgaactgact ctacaggtgg ccgaagagct ctttgccaca 240
ccgcaacagg gacggacttt gggcttggac ccagaaaccg gccacgaaat ctttgccagg 300
ggaaggccgg tttgggcctt atgttaccta tatcctgccg gaacctgcgg ctgatgcggc 360
cgcggccgct cagggan 377




224


436


DNA


Mycobacterium tuberculosis



224
agcagctagc cgcgctcgcc gcgctggtcg gtgcgtgcat gctcgcagcc ggatgcacca 60
acgtggtcga cgggaccgcc gtggctgccg acaaatccgg accactgcat caggatccga 120
taccggtttc agcgcttgaa gggctgcttc tcgacttgag ccagatcaat gccgcgctgg 180
gtgcgacatc gatgaaggtg tggttcaacg ccaaggcaat gtgggactgg agcaagagcg 240
tggccgacaa gaattgcctg ggctatcgac ggtccagcac aggaaaaggt ctatgccggc 300
accgggtgga ccgctatgcg cggccaacgg ctggatgaca gcatcgatga ctccaagaaa 360
cgcgaccact acgccattca agcggtcgtc ggcttcccga ccgcacatga tgccgaagaa 420
ttctacagct cctccg 436




225


539


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






225
cgcgactggc tccccggncg gctgctcggg tccgccgata gagaccggga tgtcgcccga 60
cgacgggcag ccgggttgcg tgggacgggg cgggggtcgg gcagcccaag caacgggcta 120
gtccccgaat cctacggagc cgtcacctac gcctacgtaa tagtagctat caataacagt 180
tgacatacgc aacgatctgt gagatcaata ttgcctgacg catgtcaaga caggcgtcaa 240
gacaggtgtc aataattcgc tccgctggtg acggtaaccg gtcgtgcggg tgtgtgacgc 300
ctaaggaagg agtgtgggtg gtgacgctga gagtggttcc tgagggtttg gcggccgcca 360
gtgcggcggt ggaggcgttg accgcacggc tggccgccgc acacgctggc gcggcgccgg 420
cgattacggc ggtggtggcg cccgcggcgg atccggtgtc gttgcagaat gcggtggggt 480
ttagcgcctt aagtagccag catgccgcga tcgccggcga aagggtccaa gaactgggt 539




226


517


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






226
atactcaagc ttattgaacc gcgggtcgca ggcaaagtgg acctcataac gactcgggtc 60
cagcgaccgc gccaacacga acggccggac gacgtgggcc agggtcgcgg cctcccctac 120
aaacaggatc cgttgcctgc gaacgacagg ctccggtgcg gcgttgggcg ccgtgctcgt 180
cccagcgtcc ggtcccgggt cgccggcgac gcttgtttcc tccatactcg ccccctaatc 240
tcgaggcagc ccgtacccgc aggcaacctc ccaaaaatgc aatcccgcaa aatgcaatgc 300
gtcnagctat ttctcacacc gaccgctagt tgcggatcag aaatccgttg ggcgcggaag 360
tccagccgaa tttgttctcc cgctccgcat catgcttgta atcgtttgga aattcatcct 420
catatgcctc gatcgcttca tagggtccag gcccaaaccc gggcaggact gggtggccgt 480
tgatgttgga atcctccact actaggtatt caccggc 517




227


488


DNA


Mycobacterium tuberculosis



227
gtctcgatca tggccaaaga gctcgacgaa gccgtagagg cgtttcggac ccgcccgctc 60
gatgccggcc cgtatacctt cctcgccgcc gacgccctgg tgctcaaggt gcgcgaggca 120
ggccgcgtcg tcggggtgca caccttgatc gccaccggcg tcaacgccga gggctaccga 180
gagatcctgg gcatccaggt cacctccgcc gaggacgggg ccggctggct ggcgttcttc 240
cgcgacctgg tcgcccgcgg cctgtccggg gtcgcgctgg tcaccggcga cgcccacgcc 300
ggcctggtgg ccgcgatcgg cgccaccctg cccgcagcgg cctggcagcg ctgcagaacc 360
cactacgcag ccaatctgat ggcagccacc ccgaagccct cctggccgtg ggtgcgcacc 420
ctgctgcact ccatctacga ccagcccgac gccgaatcag ttgttgccaa tatgatcggg 480
ttctcgac 488




228


264


DNA


Mycobacterium tuberculosis



228
atactcaagc tttcgtcagt tcatggcgcc agcagaccaa caagagcatc gggacatacg 60
gagtcaacta cccggccaac ggtgatttct tggccgccgc tgacggcgcg aacgacgcca 120
gcgaccacat tcagcaaatg gccagcgcgt gccgggccac gaggttggtg ctcggcggct 180
actcccaggg tgcggccgtg atcaagatct tcaccgccgc accactgccc ggcctcgggt 240
tcacgcatcc gtttggccgc cgcc 264




229


229


DNA


Mycobacterium tuberculosis



229
gccccgtgta atttgggatg ggcaaaaagc gaagcaccgc gtggccacga acgccgggag 60
ggacaatctc gggcggctag ggcttctcgc gggaaggccc gaacgtacgg cgtttcaaca 120
cgtcgcgtcg ccctccgacc gcgaacattc ggggatggca gcaacctggt agcaccctgg 180
ccgggcgatg atctgcagcg tcgccgcggg tagtctccgc ccgggccgc 229




230


266


DNA


Mycobacterium tuberculosis



230
atactcaagc ttcctttgac cgaacgcgtc caccgcaccg tgagattggt ggcgccattc 60
gtcgtggtgt agctgctgtt ggcggcgtcg ccgtattgtg cgggccagcc ttgtgcgggg 120
gccgcttcta cccacaagtc ggcacttccg caaccgccca gctcgaccgc gaattacggc 180
ggccgcaacg gccgccggaa ggcgtcacgc aatcgcttat cctttccagg ttcccaaatc 240
ctccgcttac ttgggtcctt catcgg 266




231


258


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






231
ggcagcggcg acaaccggaa cgtccgcacg gtgctcaatc acgggtgcac ggtgtgcatc 60
agaatggcgg gggttcgttg tcgcggtgag gcgttcggcg aggaggtagt gtctacccct 120
tgcccgcggg ttcgtgcgga ctgaaaggga tttcattggg aacccacggc tgcgtatcgc 180
agggcctcgg tgacgtctgc ttcctcnagc tcaggaagtt cggcgagaat ctcggtggat 240
gttatttggt ccgcctac 258




232


224


DNA


Mycobacterium tuberculosis



232
atactcaagc tttctcggct tctctgatag cctgagaaga aaccccaagt taatccgctg 60
cttcacctat tctccagcgc cgggttattt tcctcgcttc cgggctgtca tcattaaact 120
gtgcaatggc gatagccttc gtcatttcat gaccagcgtt tatgcactgg ttaagtgttt 180
ccatgagttt cattctgaac atcctttatt cattgttttg cgtt 224




233


333


DNA


Mycobacterium tuberculosis



233
atactcaagc ttggtgaccg gcaccgcgat acgttgcggc aggcatctgg gctggcggtg 60
gttcgccgct ccgaagccgt cgaacaccat cgccagcgcg gcttccacat caacgaccat 120
ttcggccagc ttgcggcgca tcagcggctt gtcgatgagc gccccaccga atgcccgccg 180
ctgcccggcg tatcacatcg attcgaccat cgcgcggcgc gcgttgccga gggcgaacga 240
ggcggtgccc aaccgcaatc tgtttggtca gctccctcat gcgggttgat tccttgccgt 300
ccggacgggc ccgcgtcatg cgctcggttc gcc 333




234


407


DNA


Mycobacterium tuberculosis



234
ccgttgcgca gcgtgagccg atagttgaca tccggctcgg tgaaggtgaa atcgatggcc 60
aggtcgaggt cccatgcgcg tgggccattg atgctgatcg ccaggacgtc aaagatttgg 120
tccggcgtca gctgggcgaa aaacgtgggc gccgggactt gcccggagct gcccgggttc 180
ccgtcgcgca gctcggcggc cccggtcaga aagaaattgc gccaggtcgc acactccgcg 240
ccgtaggcca gctgctccag ggtgtcggca tagagcccgc gggccgcagc gtgctcgctg 300
tcggcgaaca ccgcatggtc gagaagcgtt gccgcccaac gggaaatcac ctgcgtcgaa 360
agcttcgcgg gccagctcca gcactcggtc gatgccaccc aacgcgt 407




235


389


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






235
atactcaagc ttgcggatgt tacccctgac agcgtgaact atgtcnaaac acacggcacc 60
ggaacggtgt tgggggaccc catcgagttc gagtcgctgg cggccactta tggcctgggt 120
aaaggccagg gcgagagccc gtgcgcattg gggtcggtca aaaccaacat cggccacctg 180
gaggcggccg ccggtgtggc tggattcatc aaggcggtgc tggcggtgca acgtgggcac 240
attccccgca acttgcactt cacccggtgg aacccggcca tcaacacgtc ggcgacgcgg 300
ctgttcgtgc cgaccgaaag cgccccgtgg ccggcggctg ccggtccacg cagggctgcg 360
gtgtcatcgt tcggcctcag cgggaccaa 389




236


432


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






236
ccggtaacca gatcagctcg tcgacctcac tgccgggggt gaattcccca ccggtgctgc 60
gcgctgccca gtagtgcacc ttcttgacgc ctcgaaaagg ggagtcggtc gggtaggtca 120
ccgtcaggag ccgcctaccc aggttggcgc ggtgaccggt ctcctcgagt atctcccgca 180
ccgcccccac cggtgcggtc tcgcccggat ccactttgcc cttgggcagc gaccagtcgt 240
cgtaacgggg gcggtgaatg acagcgatct cgaccggccc ttccgaatcg gcactgccgg 300
gtcgccagaa caccgcaccg gcggcgtaca caatccggcc cgccgagcgc cggcgggcgg 360
acganttctg gatcgacacc tcaactcctg caggtcaatt cggccaagct gctcgcggtc 420
gtggatgtgg tc 432




237


287


DNA


Mycobacterium tuberculosis



237
atactcaagc ttgatgccgc cgaaaccgag cgtgagcacg ccgccaccca ccacgcgcgg 60
gtcgggcgcc gggcccgggc cgccaggctg ctccgctcgg tgatggcacg ccaccgcgac 120
accacccggc tgcgctacgt cgagccatac cgggcggagc tacatcggct cggccgccca 180
gtgttcgggc cctctttcga ggtcgaggtc tataccgatt tgcgcatccg cagccgcacc 240
ctggtcgtct cgtaccgtgc cctacctctg cttgtcgggc ggggcca 287




238


272


DNA


Mycobacterium tuberculosis



238
tccgtacggc ccgggtacgc ttcggtcgca gtgtgcgagt gatagatgac gaccgggacc 60
tcgtcggcat cttccatagc ccgccacacc ttcagttgct caccggaatc caaccggtag 120
aaggtcggcg agcgctcggc attggtcatc gggatatgcc gctcgggacg gtcagagccc 180
tcgggtccgg ccagcactcc gcaggcttcg tcggggtggt cgcgacgcgc atgggccacc 240
atccatccac caggtctgcg cgaatcaccc gc 272




239


410


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






239
ggacacattg cgaacattga tgacaaaata gaaatcattg atggtttgag tcaccaggcc 60
gatcaagcct tcgccgagcc aaattccaat caagaggccc aagcccgtac caatcagccc 120
ggcaacgagg gattccgtca ttatcagcca aaataactgc tctcgggtta cacccaaaca 180
gcgcaatatg gcgaaaaacg gtcgccgttg cacgacatta aatgtcacgg tattgtaaat 240
taaaaagata cccaccaaca aggcaatcaa actgagagcg gttaaattga ccgtaaaagc 300
gtccgtcatc tgtttgacgg tgtcccgttg ggtntccgac gtttccatac gcacaccggc 360
cggcagtctt tgttggatgc gtgttgcagt ggcctcatct ttgatgatca 410




240


439


DNA


Mycobacterium tuberculosis



240
gcctggccca ggtgaaggcc gacctcgacg ccaaagccgc tgatccggca catgagtcgg 60
tggactggga cttgaagtcg ctgcgatggg cgtggaaccg agccaaagat gacgtggcgc 120
cgtggtgggc cgagaattcc aaggagtgct actcgtcggg gttggccgat ctggcccagg 180
gcctggctaa ttggaaagct ggcaagaacg ggacccgcaa aggccggcgg gtgggcttcc 240
cgcgattcaa atccgggcgg cgtgatcctg gcagggtgcg gttcaccacc ggcaccatgc 300
gcatagagga tgaccggcgc acgatcacgg tcccggtgat cgggccgctg cgggccaagg 360
agaacacccg ccgggtgcaa cgccacctcg tgagcgggcg cgcgcagatc ctgaacatga 420
ccttgtcgca gcggtgggg 439




241


356


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






241
taactcaagc ttcaagtccg cngtccgacc ctgttcgacg gctacctgaa tcaacccgat 60
gccccgccgc ggcgttcgac ccgacagctg gtaccgcacc ggcgacgtcg cggtggtcga 120
cggcagtggg atgcaccgca tcgtgggacg cgagtcggtc gacttgatca agtcgggtgg 180
ataccgggtc ggcgccggtg aaattgaaac ggtgctgctc gggcatccgg acgtggcgga 240
ngcggcagtc gtcggggtgc tcgactatta tctaggccag cggatcgttg cctacgtagt 300
cggctcagcg aatgtcgatg cggacgggct tatcaacttt gttgcccaac aacttt 356




242


341


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






242
ccatgtcgcc caacatatcg tcgatgttcg cgtcgtccgc ctcgcgcacg tggtctgtca 60
ccagtcaacg ttaacgccgc cgcacatgtc ctgcggccgg gcaaaaacgt gaaaaacgag 120
cgggcgactg caatgtcatg acaccgacgc cgccgatggg cccagggtct ggcagattcg 180
atctgtgcgg ccagtgccag cagcgtcgcc tcgtcatacg gccggccgac gagttgaacc 240
gacatgggca tgccgtcgcc gtcgaagtcc cacggcacca cggccgcggg ctggccggtc 300
agattccana cttgaaagta ctgaagccgc tgcaccacca g 341




243


336


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






243
cgaaagcgtg aaacagctcg cggcagcccc cgacgtgctg cgtcggatag ccggcgggcg 60
aagatcaatt ccaggcagct cccggacaat gcggctctgc tggcccgcaa cgaaggactc 120
gaggtcaccc cggtgcccgg ggtcgtggtg cacctgccga tcgcacaggt tggcccacaa 180
ccggccgctt gatgcccggt cggcaagccc ggcagttgcc aaacccagcg tgatcntgct 240
cngctctnta nttcggcgaa gaagtggctc gcctgatcac ctaccatcgg ccaggatctg 300
cgtgtcatca caacgctcgc caaggaggtt gttgtg 336




244


337


DNA


Mycobacterium tuberculosis



244
tccgccacgc ttcgcgccgc ccggcatacg gcgcgtaccg atctccgcgt catacaccgc 60
gggtaatcgc cgacggtgcc ggttcgcgag ccgaaggtga cgacgctgat tgaatcgagt 120
tccaggtcca gcgggtggcg cagcaacggc gcgagctcaa cgacgtcaat cacgttgtcg 180
ctttctacgg tcaccgaccc ggtgaccgta gtcgcccggt gcgctcggcc gagaagctgc 240
accgccacca ccgcgacacc gtcttgcacg cggacccacc ccggatcggt tgttggccaa 300
ggtaattggg tcattccatt tgacgggacg ccgaccc 337




245


337


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






245
cattctttaa cagttgtttt gggctcggca tggttagcca acgttctgcg gtccaccata 60
tcatcttggt ccggtagcgc tcgtccgggg tatgctgccg ccgggattct cgctgctatt 120
actccccccg aagaaccgcc accggtccag cgcgtgggcc gncgcggtcc catcacaaac 180
tgaaccccca acagggacat gcttatcggt agggcgcgcg ccaaggcggc agcaatcgca 240
tcactgcgct ctgcgcgtca ctattaaccc acccggactt cacttccacc accccgaatg 300
gcgcccggtc attgatcatc tggcgcaccg cggataa 337




246


343


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






246
cggtgtcctg cagttggtag gcctgcagtt tgtgcatcat gccgatgccg cggcctcgtg 60
gccacgcatg tacagcacca cgccgcgccc ctcacgggcg aacatcgcca gcgcggcgtc 120
cagctgaagc ccgcaatcgc agcggcgtga ccaaacacat cgccggtcaa gcactccgaa 180
tgcaccggac cagcacgtcg tcaccgtcgg cgttgggccc ggcgatctcg ccgcggacca 240
tgcgcgacat gttccacgtc ctcgtanatg ctggtgtagc cgatggcgcg aaactcccca 300
tgacgagtcg gaatccgcgc ctcggcgacc cgctcaatgt gct 343




247


340


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






247
cggcatctgg cggctgaacc tgttcttggg caacatgccg aggatcgcct cttccaccac 60
gcggtcgggg tggcgttgca ttacctcacc gatggtgcgc ttgtgcaggc cgccgggata 120
ccccgagtgc cggtaaacca tcttgtgctg cagtttgtcg ccgctgatgg cgaccttgtc 180
ggcgttgatc acgatnacna atcaccgcca ncgacattgg gggcgaacgt cggctcgtgc 240
ttgccgcgca gcaggctggc cgccgcgacg caaggcgcca accaccacgt ccgtggcgtc 300
gatgacgtac caccatcgcg tggtgtcacc cgccttgggc 340




248


322


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






248
gcggcaaaaa ttgaagcact cntggccact nccgccggga gggacaatct cgggcggcta 60
gggcttctcg cgggaaggcc cgaacgtact gcgtttcaac acgtcgcgtc gccctccgac 120
cgcgaacatt ctgggatggc agcaacctgt tagcaccctg gccgggcgat gatctgcagc 180
gtcgccgcgg gtagtcgccc ccgggcggct acagtctgaa acgcgatgac catcgatgtg 240
tggacgccgc atccgacnca acggttccta cactgtgata tgttcgcctc gctgcgccgg 300
tggacggtgg gtctatcccg ga 322




249


278


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






249
cgcgttgaac tgaaggggtg ccgcccggct cgagcaggca agccatttgt tcgatgcggt 60
taccgaagat ctcttcggtg actgcccgcc gccggccagc tcggctcagt gtccggcgtt 120
ggtcgccgcg gcgacaatct tggcgtccac ggtggtcggg gtcatgcccg cgagcaggat 180
tggcgagcgg ncggtcagcc gggtgaactt cgtcaagagc tgacgctgcg gttggggagg 240
cgaatcatgg tcggtgcgta gcctcgacta ggcccggg 278




250


336


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






250
tgacaacgcg gcggcgatta ccccgctacc gcagcagcat gacgcggtag cgaacaccgc 60
cggatgcagc gcaggtgcgt cgatgtgctc acggaatcgc cccggcaccg cgatctcgag 120
gatcaccagt gccaccccct gcagcgcgac accgacgatt ccgtacaccg ccacgccgat 180
caggccctgg gccagctgat tggagctggc gtatatggcg gcgatggtga cgatggtcat 240
cgcctcttac attgtggcgg ccagaaccac ggcgttgggg cggcggtcga tgaacactag 300
gcgaccanat ccccggggtc aacaggttga ccatcc 336




251


95


DNA


Mycobacterium tuberculosis



251
cgcggacatc ccgaacgagg acacgcgacc gcttcggtgt gtgatctatc agggctcgca 60
ccacgcgcaa ccgcttccgg ctacctagac gcggt 95




252


94


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






252
gcatgcgggt gatgccgttc tcagtgcgca acagcgttcg acgcggcata cccagccgca 60
catgccgtgc acgccggngc cggggcggga atct 94




253


302


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






253
ctcaagcttc agnccntcta agcggtctgc gcggcgatcg caaagatcgc cctttgccgg 60
cgttgggggc ttctgctcgg gggtgttgta caccttctcg aacacctcgg caccgacacc 120
accaccgtcg gcttgaacac cgccaacatc ggcagcanat cttgatgtcc tggtgaatcc 180
acggtgactt tggagtggaa ggcggccata ctgatcgcgc gcgccaccac atgagctagc 240
ggcaggaaaa ccagcagccg ctcacccttg cgcagcagcg tcgggtgata tgcctggcgc 300
cc 302




254


291


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






254
agtcgaangt cagtccggtc tcctctccga ctacggccaa gaactggggc gacggtgtca 60
gtgcagaaca gcggaaactg gtggcgccct aggcgagcga acgctcacaa acggcggtga 120
ccgcttctgg tcgtgcacca tcgagccgtg cccagcccgg ccgcgtgccg tcagccgcat 180
ccactggatg cccttctcgg cggtttcaat cangtacagg cgacgttcgc caccatcgtg 240
ccggggcacg gttagcgaga aacgccgact tcaccgattg cctcggtgat g 291




255


454


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






255
agcttcgcgg cgtggcgatc gcggttcaag gcgcgctctt cgagcacaac gagcgaagac 60
agctcggcga cggagccttt atcgacatcc gttcgggctg gctgaccggc ggcgaagaac 120
tgctggacgc gttgttgtcg acggtgccgt ggcgagccga gcgccgtcag atgtncgacc 180
gggtggtcga tgtgccgcgg ctggtgagtt ttcacgacct gaccatcgaa gatccgccgc 240
atccgcagct ggcgcggatg cgccggcggc tcaacgacat ctacggcggc gaactgggtg 300
agcccttcac caccgccggg ctgtgctact accgcgacgg ctctgacagc gtcgcctggc 360
atggcgacac cattggtcgc ggcagcactg aggacactat ggtggcgatc gtcagcctcg 420
gcgccacccg cgtcttcgcg ctgcggccgc gtgg 454




256


346


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






256
agcttcagct gatactcgac cagccccact cgggccaata cgtgaatgtc tagcatcttc 60
acccgttcac gggctantcg agtagtagac attgattagc ctgaacgtac ctccgacgcc 120
agctgacgaa cgggtatgac ggatggattt cgtggtgtcg cgcccgaggt caattcgtta 180
cggatgtatc tcggggccgg atcggggccg atgttggcgg ccgcggcggc ctgggacgga 240
ctatccgacg aactggcggt ggcggcgtcg tggtttgggt cggtgacctc gggcctggcg 300
gatgcggcgt ggcgcggccc gcggcggttg cgatggcncg cgcggt 346




257


339


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






257
ctggtcatgg acgttgctcc ggtagtggct cactgccgat cctcctcgtt gagagtgcca 60
cctcagggtt gggtagggtt gggtactcga aaccaagtta cccaccagta acaccgtcaa 120
aatatatccg ttgcataggt caatgcaagt tgatgtgagc tacattgcac caactaacta 180
accaaccggt tgggttagcg gtgatcctgg ccgtgtcggt cctctcacct gcggtgatag 240
cgatcaaatg aagaatatgc ggagtctagg gcggcagcgc ctggcancgt agatcatcgg 300
ctcacgcgga tgcggcctct tggtacggac atgcgcgcg 339




258


182


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






258
ctcgtgagta gcacccctgt aatttgggat cggcaaaaag gcgaatcacc gcgtggccac 60
gacacgccgg gagggacnat ctcgggcggc tagggcttct cgcgggaagg cccgaacgta 120
cggcgtttca acacgtcgcg tcgccctccg accgcgaaca ttcggggatg gcagcaacct 180
gg 182




259


213


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






259
ggatcaacta ccggccaacg gtgattcttg ggcgccgctg acgcgcgaac gacccagcga 60
cacattcagc agatggccag cgcgtgccgg gccacgatgt tggtgctcgg cggctactcc 120
catggtgcgg cncgtgatcg acatcgtcac cgccgcacca ctgccggcct cgggttcacg 180
cagccgttgc cgcccgcagc ggacgatcac atc 213




260


321


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






260
aggaccgtca gcacggcgac gtgctactcg ccgagcagtg ggaatcgctc tgcagcaaac 60
cattactctg cgcgacgttc gagatgacct tctgaatgga cggatctacc tgccgcgcga 120
cgacctggac cgcgtatgcg tccgcctccg cctggacgac accggggcac tctatgaccc 180
cgacggacgg ctcgcggtac tgctgcggtt caccgccgac gcccgcacgg tacgcgtcgg 240
gactgcgctg agtccancct cgacgccgta gcgctgctgc tgtgcggcca tgtctggcat 300
ctaccgccgt cgctcccttg a 321




261


334


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






261
cgactctgtt ggccactgcg ggtcgatctt gcggccgccc cggtcgtgga acgcccaggt 60
cacccggcgg cgcaccgcgg tcagcgcgtc gttggccagc gtggtcacat ggaagtggtc 120
gacgacgagc ttggcgttgg gcagcagccc gggcgtgcgg atcgccgagg cgtatgcagc 180
ggcggggtcg atggccaccg tactggatgc tctcccggaa ctgcggtgtg cgcgcttgca 240
gccatgccag caccgccgcg ccgccgcggc cttcatgctg cccataaacc ctgataccgg 300
ccaggtcgac naaccngtat cccacggtca accc 334




262


208


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






262
cacacggacg gcggtgcgga cgcagctgac gcgcatggtg gtcagcatcg cggccggtct 60
gctgttgtat gcctacttcg cgccgcgcaa atgctggtgg gcggcggtgg tggcgctcgc 120
atggctgggc tgggtgctga cccaactctc gaaccacacc ggtgggtggg ctgggctatg 180
gcctgccata tcggcctggt gttctacn 208




263


233


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






263
ccgatatccg agccgatagc tggcgggctc gggtggtngc cagcggcgct gcgacgaaag 60
tgtgaccgtc atgaaacaga caccaccggc ggccgtcggc cgtcgtcacc tgctcgagat 120
ctcagcatcc gcagccggtg tgatcgcgct ttcggcgtgt agtgggtcgc cgcccgagcc 180
cggcaaacgc cggcccgaca caaccccgga acaggaagtc cggtcaccgc gcc 233




264


320


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






264
gcttcaggac aaattgnatc cctatgcacc cgttgtcacg ccgatgagtg aagactgcac 60
gcaatcgccg gaatccggca aaaccctgca caagcgaaat caaccggagg ctgacaaggc 120
aacgtcggtg atccgtaccg cctggttgga caaacggcag aaggcgcctc gtccggtcca 180
tctacgccga gcacactggt gatagcgcca tcggcatcgg tgcggccacg gtggagacga 240
acgtccgcng gcgtctgggt cagtaacccg ccgaccagtt ctcgggcaag ctggtcaaca 300
tcgggcgcca cgtctccaac 320




265


304


DNA


Mycobacterium tuberculosis



265
gtttggcggc cttattgcac tgaggtcgtc aattgaccca cagcggaaat gccgactatt 60
cgcaggcctc cttcgccttg gctgccggag atgggctccg cgggaaccgc atgcaggtat 120
atgacctcgg tttctcgggt gctaccgcgt gccttgtcga ggatgaactc ggcgttggaa 180
ttgtccagcc ggcccaattc atcgagcgca gattcgtaca catggccggc ggcgacatac 240
cttcaccgtg gatctgctcc acacggaccg ccctgtcggg atctgctcac gggtaaagga 300
atta 304




266


217


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






266
gcgcactcct ccttatcgct ccgctctgca tcgtcgcggc gcggtcaggt gcaaacgcct 60
tcgggggtgg gggtcctgcg gagcacaccg gatacggagc gcaacgcgtc gcgttgtgcg 120
ggcaaacaag tgtgcaggnn ccaatgccat gtccagcagc ttatcagtgt cgaacgtgcg 180
aacgtcgcgc cttcgccggt gcctgaatct ctacaag 217




267


174


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






267
cgctgaaagc caccattcgc gggtcgggcg ccgggctcgg gccgccaggc tgctccgctc 60
ggtgatggca cgccaccgcg acaccacccg gctgcgctac gtcgagccat accgggcgga 120
gctacatcgg ctcggccgcc tagtgttcgg gncctctttc gaggtcgagg tcga 174




268


144


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






268
tgtaatttgg gatgggcaaa aagcaaanca ccgcgtggcc acaaacgcgg ggagggacaa 60
tctcgggcgg ctagggcttc tcgcgggaag cccgaaacgt acggcgtttc aacacgtcgc 120
gtcgcctccg acgcgaaatt cggg 144




269


216


DNA


Mycobacterium tuberculosis



269
cttgggcaac atgctgagga tcgccttttc accacgcggt cggggtggcg ttgcattagc 60
tcaccgatgg tgcgcttgtt gcaggccgcc gggatacccg agtgccggta aaccatcttg 120
tgctgcagtt tgtcccgctg atggcgacct tgtcgcgttg atcacgatga cgaagtcacc 180
gccatcgaca ttgggggcga actcggcttg tgcttg 216




270


199


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






270
gcatgcttca ttatctaatc tccagccgtg gtttaatcag acgatcgaaa attcatgcag 60
acggtcccaa atagaaagac attctccagg caccagttga agaggttgat caatggtctg 120
ttcaaaaaca agttctcatc cggattgaac tttaccaact tcatccgttt catgtacaac 180
atttttagaa ncatgcttc 199




271


230


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






271
atactcaagc ttgatgccgc cgaaaccgag cgtgagcacg ccgccagcca ccacgcgcgg 60
gtcgggcgcc gggcccgggc cgccaggctg ctccgctcgg tgatggcacg ccaccgcgac 120
accacccggc tgcgctacgt ctatccatac cgggcggagc tacatcggct cggccgccca 180
ttgttcnggc cctctttcga ggtcgaggtc tataccgatt tgcgcatccg 230




272


188


DNA


Mycobacterium tuberculosis



272
tccgtactgg tcgggtacgc ttcggtcgca gtgtgcgagt gatagatgac gaccgggacc 60
tcgtcggcat cttccatagc ccgccacacc ttcagttgct caccggaatc caaccggtag 120
aaggtcggcg agcgctcggc attggtcatc gggatatgcc gctcgggacg gtcagaacct 180
cgggtccg 188




273


158


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






273
gttctcgcac gatttcggat tagcgggatg gtctcaattg ggtatgcggg gaaggcgctg 60
acattcgccg cgattagctg tttgatggac cgggggtgat ttttgatcac ggaaatgggt 120
gtttatncag gtcgcacgct ttcatccggg gcggaacg 158




274


237


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






274
gggtgtgcct gctgtgtatg cacggcatac ggacatcctt cccctgaaga cccgcggtcg 60
aacagccacg tgtccatcat canggggtca accccggcca agggcgacgg cacgccaagt 120
tcgccgaccg ttaacctagt gctgttagct tcatttgctg cgagcaaaac agctggtcgg 180
ncgttaggaa tgaattgaaa ctcaaccgat ttggtgccgc cgtaggtgtc ctggctg 237




275


262


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






275
actacccggc caacggtgat ntcttggccg ccgctgacng cgcgaacgac gccagcgacc 60
acattcagca gatggccagc gcgtgccggg ccacgangtt ggtgctcggc ggctactccc 120
anggtgcggn cgtgatcgac atcntcaccg ccgcaccact gcccggcctc gggttcacca 180
gccgttgccg cccgcagcgg acgatcacat cgcttttatt tnntnttcng gaatccctcg 240
ggccgcgctg gcgggctgat ga 262




276


222


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






276
acgtcgggan actgttcgcg ttcatcctcg tctcggcgga ttggtctgct gcgccggacc 60
gaccgatctt cagcgggggg tcacgctccg tggggtgccg ttacttccga tcgcccagtg 120
tgcgcgtgct gtggctgatg ctgaacctca ccgcgttgan ttggatcggt tcgggatctg 180
gctggtggcc ggaacgcnat ttatgtcgct acgggcgccg gc 222




277


166


DNA


Mycobacterium tuberculosis



277
gctcaaaggc actactggca ccaaggccca cacgtcacct gtgactcctg cgccgacccg 60
cccgaggtct ggccgttaca ccgaacgggc gagccgggag ttggtaccat cgaacaagac 120
aaggtgcatg ggcggagttg ttccgccact tcgtcgatga cgggtc 166




278


330


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






278
cgataccggc tgcttaccga gacatccacc atgccacccg aatcaccgca cgcgccgaaa 60
tcgcacaaca gcttgacgcc ttgcaggttc cgcgattgga attgccgacg gtctctgacg 120
gcgtcgacct tggcagcctc tacgagctct cggaatcact tgcccagcag ggggttcgat 180
gagtgtcaca ccgaagacct cgatatgggc gcaatcctgg ccgacacatc caaccgggtg 240
gttgtgtgct gcggcgccgg tggggtcngc aanacactac cgcggccgcg ctggcgttgc 300
gcgcggccga atatggccgc actgtggtcg 330




279


332


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






279
cgtcgtcgtc gtggtatgcg atagccatcc cgtcgggcta ctcgccatca ccgatcagct 60
tcgccccgaa gccgccgcgg cgatttccgc tgcgaccaaa ctgaccgggg ccaaaccggt 120
attgcttacc ggcgacaacc gggccaccgc cgatcggctc ggtgtacang ttggcatcga 180
cgacgtacgg gccgggctac tgccgacgac aangtcgcag ccgtgcngcn gctgcaagct 240
ggaggtgcca gattgaccgt ggtcggtgac ggtatcaacg acctccggcc ttagcggccg 300
cgcatgtcgc atcgccatgg gcagcgcccg ac 332




280


222


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






280
gcacgcaatc gaagtcaccc aaaccgggcg ggccaggcgt ctnacgccac gtcnaccagc 60
cgcaacctca acccggccac ggcgagctcc tgatcaaggc cgaggccatc ggtgtctact 120
tcatcgacac ctacttccgc tccgggcaat atccgcgcga actcccgttc gtcatctgct 180
ccgaagtatg cggcacggtg gangccgtcg gccaggggtt ac 222




281


184


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






281
tcgactgtgt ggccacagat cacgccccgc atgccgagca cgagaaatgc gtcgaattcg 60
ccgcgggccg gccggcatgc tcgggttgca gacggcattg tcggtggtgg tgcatacaat 120
ggtggcgccg gcttgttgan ttnggcgcga tatcgcgcgg gtgatgagtg anaaccggcg 180
tgca 184




282


409


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






282
gaacctgaca ccctggtcac gggtgagcac ggacttgatt tcttcnctat tggtcggcgc 60
tgttgagcac accacgccgc tgacggccgt cgcgtcctcg ctgtgctcgg tctggtggag 120
cgcgctgccc gcggccnaac atcntaaatc aagcgtattc gtcaacagat atcatcaatg 180
tcggcgctgg actattcaaa tcatcgatat actggtgacc tggtccttcg ccatcgatca 240
atggcgatag tcacgcaaat cgtcacggac atcgtcggcg tcccagctgg cccgtgccaa 300
cagatgctgc aacccatcgg ggtggtatca ccgcggtgct cggcgatggt ccacaattct 360
tgcggtccaa gcccnaaaca tcccgggcat gaattcaccg gcatgcgcn 409




283


413


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






283
ctatcgtacc cgcgccggtc accttctgga tatcgccggc ctggtcaagg gggcgtccga 60
gggagccggg ctgggtnaca agttcctggc tcatatccgc gaatgcgacg ccatttgtca 120
ggtggtgcgg gtgttcgtcg acgacgacgt gactcatgtc accggacggg tcgatcccca 180
gtccgacatt gaggtcgtcg agaccgagct gatcctggca gatctgcaaa ccctggagcg 240
ggccacgggc cggctggaga atgaagcgcg caccaacaag gcgcgcaagc cggtctacga 300
agcggcactg cgtgcccagc angtgctcga cgccgggcaa gacgctgttc gccgcggggg 360
tggatgccgc cgcgttgcgc gactgaaact gctgaccacc aagcccttcc tgt 413




284


283


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






284
tactcaagct tcaggccgcc acgtccgccg tccgtcggcg acgtgacctc gagcgccgag 60
ttcgactcga catcgccgcc ggcgcatgcc gacatgaacg cggcactcac cgcaagcccg 120
tcggacgtca ggtcgatcga ctccgcttca agcaccggat cgtccgggca actcgcggcc 180
tcggcctgtg cgaacggcac acccgtcgtg gcggcncccc gcgcggaact gggctcatca 240
cggtcgttgc gagccggtcg cgtcaccgcg taccgacgcc gtc 283




285


397


DNA


Mycobacterium tuberculosis



285
ccgacatcga gtgggctcgc agtgacttgg cgacctccaa gccaccggta cccgccgcgc 60
ggcaagccaa ggacgacgac ggccttgccg gatagctgcg ccaggcgttg cgccaactgg 120
cgtccagcgt cgccacgatc gtcaaagagc ttcatctgcc gagtgtgtcg ccatctcatg 180
gctccaaata tggaattagg tccctgggcc gactgacgac agtccctcag cgaccggatt 240
gcgcatcccg ccttgtacgc tactccgcaa atcccgggct tgcgtccgcg gaagcgaact 300
cggcggcgct acgtggtggt tcacttcggc cgtgcgcact cggatcgacg ggccgatggt 360
ggccgggccc gcgcgcttct tggtcatccg attgagt 397




286


342


DNA


Mycobacterium tuberculosis



286
atactcaagc ttgtcgcggt aaaccgcacg cagggcggtg ggtgcggtgt caaagacacc 60
cacacttctt tgcggttcgg tgatctcgac accggccgcg agccgaccac catgcgcgcg 120
tagatcggcg atcagcgcgt cggctatcgc ctgggtgccg cccaccggaa tcggccagcc 180
gaccgaatgg gccagcgttg ccagcatcag tccggcgccg gccgacacca gtgacggcaa 240
cggtgaaatc gcgtgggcgg caacgccggt gaacaacgcg cgggcatcct cgcccgccaa 300
cgaccgccag gcagggtgcc tgggccatca tccgcagccc ga 342




287


430


DNA


Mycobacterium tuberculosis



287
tggactcata acgatcgggt cagcgacgcg ccaacacgaa cggccggacg agtgggccag 60
ggtcgcgcct cccctacaaa caggatccgt tgcctgcgag cgacaggctc cggtgcggcg 120
ttgggcgccg tgctcgtccc agcgtccggt cccgggtcgc cggcgacgct tgtttcctcc 180
atactcgccc cctaatctcg aggcagcccg tacccgcagg caacctccca aaaatgcaat 240
cccccaaaat gcaatgcgtc gagctatttc tcacaccgac cgctagttgc ggatcagaaa 300
tccgttgggc gcggaagtcc agccgaattt gttctcccgc tccgcatcat gcttgtaatc 360
gtttggaaat catcctcata tgcctcgatc gcttcatagg tcaagcccaa acccggcagg 420
atgggtggcc 430




288


473


DNA


Mycobacterium tuberculosis



288
ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc 60
acacaggaaa cagctatgac catgattacg ccaagctatt taggtgacac tatagaatac 120
tcaagcttag tggttgcgca cgtaaattcg tcaggtgacc gatcccctgc tgtctcactc 180
gcctcacagc gaccaccacg gctggcgctc aaggcgggca cgtgcggagc agatgaggaa 240
tgtgcgacgt cttgatgcag cctgtcagaa caccgagacc ctcgacgaac ttacgatcga 300
aaccgcttag gccaaccggt gacgggggtg tctttccgcg gctagggcgc cttatcgtcc 360
gaaggccgtg ggtggtgatc gccttctggg tcgcgcttgc gggtctgctt gcgccgacgg 420
tgccgtccct ggaccgatct cccagcggca tccagtggcg attctgccat cgg 473




289


418


DNA


Mycobacterium tuberculosis



289
caggcatgca agcttgcgat gtatcaacac gccgttgcgc agcgtgagcc gatagttgac 60
atccggctcg gtgaaggtga aatcgatggc caggtcgagg tcccatgcgc gtgggccatt 120
gatgctgatc gccaggacgt caaagatttg gtccggcgtc agctgggcga aaaacgtggg 180
cgccgggact tgcccggagc tgcccgggtt cccgtcgcgc agctcggcgg ccccggtcag 240
aaagaaattg cgccaggtcg cacactccgc gccgtaggcc agctgctcca cggtgtcggc 300
atatagcccg cgggccgcag cgtgctcgct gtcggcgaac accgcatggt cgagaagcgt 360
tgccgcccaa cggaaatcac tgcgtcaaag cttcgccggg ccactccagc actccgtc 418




290


194


DNA


Mycobacterium tuberculosis



290
atactcaagc ttgaccgacg ctgatcgcac cgcacgcggg aacctcaagg gcactactgg 60
cacaagggcc cacacgtcaa cctgttaact cctgcgccga ccccggccga agtccttggc 120
gttaacaccg aacgggccaa cccgggaatt tgggttccat caaaacaaat agcaggtgcc 180
tgggcggagt gttc 194




291


166


DNA


Mycobacterium tuberculosis



291
gtcgtcgtgt gctggggcgt ccgtatcagc acgcccacga aatggggcac aagaaggatt 60
cctggaacgg tggctgtcca agatcaccct cgcccaaaac tgctacgggc acttctacat 120
cgagcacaac cgtggccatc acgtccgcgg tgtccacacc gggagg 166




292


291


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






292
atatgccttg ctgagctttt cggatcgcag cgagtcgtac ccgcgccggt caccttcgtg 60
gatatcgccg gcctggtcaa gggggcgtcc gagggagccg ggctgggtaa caagttcctg 120
gctcatatcc gcgaatgcga cgccatttgt caggtggtgc gggtgttcgt cgacaacgac 180
gtgactcatg tcaccggacg ggtcgatccc cagtccgaca ttgaggtcgt cgagaccgag 240
ctgatcctgg cagatctgca agccctggag cgggccacgg ggcggctnga a 291




293


442


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






293
gacaccctgg tcacgggtga gcaggactcg atttcttcgc tattggtcgg cgctgttgag 60
gcacagcacg ccgctgaggc cgtcgcgtcc tcgctgtgct cggtctggtg gagcgcgctg 120
cccgcggccg aacatcgtaa atcaagcgta ttcgtcaaca gatatcatca atgtcggcgc 180
tggactattc aaatcatcga tatactggtg acctggtcct tcgccatcga tcaatggcga 240
tagtcacgca gatcgtcacg gacatcgtct gcgtcccagc tggcccgtgc caacagatgc 300
tgcaacccat cggggtggta tcnccgcggt gctcggcgat ggtccaacaa ttcttgcggt 360
ccaagcccga aaccatccgg ccatgagttc accggcatgg cgcaacggct ggtgccgggc 420
aaaacgcggc gcgatcgaat tc 442




294


150


DNA


Mycobacterium tuberculosis



294
tgtagaaggt gggtcccgtc caacttcgcg gcggcggcgc gatatgcctt gctggtcttg 60
ctcatttgat atccaatcta tgggtcgtgg ttactcaacg ggccgaagct ggccctccca 120
cgggtagggt cctattcgac ggtgatgtcc 150




295


321


DNA


Mycobacterium tuberculosis



295
cccgaatccg gtggccggca gggggcctgg cgacgtggac accttctaac ttgtctttac 60
cggtcactgt tgcaccccaa cacctttaac gacgtggacg gacgttacat cggattcgac 120
ggtgtcatcc acagcgttgc cattgggcac acccactacg ccaatttctc cgactgggac 180
acctaccgca gcctcgcccc actgcaggga ctgttgttcc cgcaacgggc catcgacatg 240
atccagtcgt tggtgaccga cgcggagcag actggtgcgt atccgcgttg ggcgctggcg 300
aaattccgcc accggcatga t 321




296


184


DNA


Mycobacterium tuberculosis



296
ttgagatgct ggtcgggatg ccgatggttg gaacatggtc ccctggcgtc gaatacgcgc 60
gagcgcatga gctcaccggt tcggaacaac gtatcgaaga actcgcactg ctggcagatg 120
gtatctccga tgtggttgta atttgtatcc caactctaac tgtgctatcg gatctgcgtg 180
aata 184




297


259


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






297
cgtaatcacg atcccgctga gacacttgac cttacggccg aagtgacttc gctgctgcta 60
tgccgacacc cgatttccat acgctgctgt acacgacggc cgggccggtg gcctccatca 120
cgctcaaccg cccggaacag ctcaacacca tcgtcccgcc catgcccgac gagatcgagg 180
ccgctatcgg gttggtcgaa cgcgaccagg acatcaaggt catcntnctg cgcggtggcg 240
ggcgcgcctt ctccggcgg 259




298


369


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






298
caagcttaag ctggttccgg ccactccatg agccgtagtg caatggttcg tgcacggcga 60
ggccgaactt gccataaaca tccctgacga aagtctccgg caagccgatt gcttcttcgg 120
gccgcttctt gtggattgtc cgataacccg gtccctcatg ctggaagttg tgcgcactct 180
ttccttccgc gatgtgggct aacgactcgt cattgagcaa gaagtacgtg cacaggcatc 240
gtccgccggg cttcagcacg cgggagatct cgtccagata gtgctccacg tccggnggga 300
aacatgtggg tgaacaccga ggtnagaaac accncatcca acgacgcatc cgggatatgg 360
aaagcgaaa 369




299


387


DNA


Mycobacterium tuberculosis



299
tatggtcttc gtcgaccagt acgtcgtagg cgccatgagc cagcgactga agccgcgcca 60
tgcctgcacg gcccgctcat ccagcgaggc ggccatctcc cgcagatagc ctgccgcctc 120
ggcgcgcacg ctgtccggat cgcgtccgag ctcgtcggcc agcgcacgca gccgctcgtc 180
ataccatcgg gcatccagca gttgggtaac ctcaacgggg tcggtcgcta gcggcgtcat 240
tgattcagca acaataccga tgcgctgcag caactttcgc agtccgatgc ggcccacctc 300
ccgtgcagtc actggctagc ccccgtcatg ccggttgtgt cgatggcacg gcagcgggct 360
cgtaaacctg cggtctcagc tcgctgg 387




300


73


DNA


Mycobacterium tuberculosis



300
gcttagcggt cttgctcgaa ccgacattgc gtgccactca tgagcgggtg gcggtcgcgg 60
tgcttacaca tct 73




301


156


DNA


Mycobacterium tuberculosis



301
gtatctggcg cctctcgaat atccttgaac gtcccgcggt gccacccaga tagatcgcag 60
cgccctgcaa tggagttccc tttatggcct ctctagcctc ccgcttgatc ggctcgaccc 120
gagagatgcc ctcgggcgtt gcgggatctc cctcca 156




302


394


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






302
cttcacgccg atccgcgacc gcgaacgcga cggtgacggt gggcgacaag gttcggttgg 60
tcgccgcggc gctgggcgat atcagctcac ccggtttcga ggtgttcggc gaccggacgg 120
tgctgcagac attcttgagc gtcctcgacc ggcccgattc ggccttcaac atcgtgacgc 180
cgtatttcgg cggtaccgct cggcgccgag tcgaaggcgg cctgagctaa agccgggcat 240
tgcgcgagtg gtaaacaagt tcggtgactt cggttgaccg actcgacggg ctcgatctgg 300
gcgcgctgga ccggtatctg cgttcgctgg ggatcgggcc naccgcnant tgcgttgcga 360
nctgattccg gtggagctcc aatctgactt ccgg 394




303


404


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






303
gcagctaccg accctagcga cgagtgtgtt cgcagcgtcg aatgtgaacg ttcggcgtga 60
ttcggcgcgc gggttcccgc tctcagcgca cgttcggcgc cgaggnggct agtccctggt 120
taagcaatgt ctcggtcgcc gccagcagcg cgcatgtcgc caacccgtcn accgcgttgc 180
gcatgtccgg taccgacgga aacgacggcg cgatccggat gttcttgtcg tccggatcct 240
ttcgatacgg gaacgacccc ccgcctcggt caccgcgata ccaacgtcct tagccaangc 300
tacngtccgg cgcgcggtcc cgggcaacac gtcgaagctg atgaantaac cacccttggg 360
ctcggtccaa gangcgatct tggactcctt aaccgctgat ncaa 404




304


479


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






304
tccccatcgg cgccggaccg tttgaaagtc caagcacggg tgggatggaa tcgacgacag 60
ttgagcgccg tcggtggccg tggtcagcag ctgttcgcga acgcaccagg tcacatccct 120
tcgacatctc accgacgtgg cacgggcgac atcaacagga agattgacga atccctcgca 180
ggcgcggcac gtccgcaggc caacgccaac tacggggcca ccagcgatcc tccgctcacg 240
caccagccca agccaggctc anccacccaa gtcggcccgc gctctccctc gccccctggt 300
ctccggggcc ttgttaaaca actaccggaa gtccaccaat cctcgctgca tctcgacacc 360
gtccgcctca ctcccttcct cccgcccctc tccacacnac acacctcttg cattaaggtc 420
acggagcggt cacttttcgt cggacgaaat tcgcaatccg gccgctcgcc gccagagat 479




305


260


DNA


Mycobacterium tuberculosis



305
cggaaagtgg atactcccag caggtagcag gtcgccacca cgctggtcag tgcgcgttca 60
gctcgcttgc ggcgctgcag cagccagtcc gggaaatagc tgccctggcg cagcttgggg 120
atcgcgacgt cgatggttgc ggcacgggtg tcgcaaatca cggtggcggt agccgttgcg 180
ctgattggac cgctcatcgc tgcgttcgcg gtagcccgcc ccgcacaggg cgtcggcttc 240
agcccccatc aaggcggcga 260




306


464


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






306
ggccgagtcc agcacttcgc actatgtgca gaccaaanac ccggtggtcg ccgcgctgcg 60
gcagcggctg gcaacggcgc cggtgatcac cgagtggtgc gnagttgccg accggcagtt 120
cgccgcgggc ttactacgag aagggcctgc gcgacgtcat caggtatcac gtgtcgatga 180
cgtcgagcgt taacttcccc gaccagacgg cgacctcgcc gatggacccc gcgttgtacc 240
tggtgtgggc gcaagctaac gccgccgcan gctatcggta ctcggtcgaa gcgcagccgg 300
ggtcgcaagc gctagcgggc aaggtcgcga cgatctcggt cacctggacc aactacggcg 360
ctgctgccgc caccgaatag tgngtgcccg gctaccggct ggtggattcc acgggacatg 420
tggttcggac ctgccggcag cggtggaact gaagangctg gtct 464




307


315


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






307
agcttcaagg acatcgtcat cgcgaccaaa accgcgagct aggtcggcat ccgggaagca 60
tcgcgacacc gtggcgccga gcgccgctgc cggcaggccg attaggcggg cagattagcc 120
cgccgcggct cccggctccg attacggcgc cccgaatggc gtcaccggct ggtaaccacg 180
cttgcgcgcc tgggcggcgg cctgccggat caggtggtat atgccgacaa agcctgcgtg 240
atcggtcatc accaacggtg acagcagccg gttgtgcacc atcgcnaacg ccaccccggt 300
ctccgggtct gtcan 315




308


331


DNA


Mycobacterium tuberculosis



308
gctcgcggtc cagcagcaga cgtgtctgac cccgacgccc ggccgccggt accgaaaccg 60
gatcggcccg ccgatggccg cggccacggc gtctgcctta cccggcccgg ataccagcag 120
ccacacctcg cgggaacgct gaatcgccgg cagggtcaag gtgattcggc gtggcggcgg 180
tttcgcgaat cgtccaccgc caccaccatg cgggtgctct cgaagacgcg gggctgtgcg 240
ggaacagcga gttaatgtgg ccctcgggcc ccatgcccag caggtggacg tcgaaattcg 300
gcccgggtca cctggtgcgg cactggcggc c 331




309


286


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






309
agcttgtcga tcgtccggca gcgtccggcg agtcaagtcg aagccagtcc ggtctcctct 60
ccgactacgg ccaagaactg ggcgacggtg tcagtgcata ccagcggana ctggtggcgc 120
cctaggcgag cgaccgcctc acaaacggcg gtgaccgcgt tctggtcgtg caccatcgag 180
ccgtgcccat cccggccgcg tgccgtcagc cgcatccact ggatgccctt ctcggcggtt 240
tcaatcaggt acaggcgacg ttcgccanca tcgtgccggg gcangg 286




310


331


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






310
ttggtgatca tcgncccaac gaccccgagg cgatgttctt gcacaccgag gagtgtcgca 60
agctggggct ggccttcgcc gccgatccgt ctcagcagct ggcgaagctg tcggggtgag 120
gaaattcgca ggctcgtcaa cggtgctgct tacttgttca ccaacgacta ctaatgggat 180
ctgctgctgt ccaagaccgg ctggtcagan gccgatgtga tggcgcagat cgacctgcgg 240
gtgaccacat tgggtcctaa gggtgtcgat ttggtagaac ctgacgcacc accatccacg 300
tcggcgttgg tccccgaaac agccagaccg a 331




311


458


DNA


Mycobacterium tuberculosis



311
ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga 60
ccatgattac gccaagctat ttaggtgaca ctatagaata ctcaagcttg attttgatca 120
tcatgatgat catcacccga agtgtggtag ccgcagtggt tatcgtgggt accgtcgtgc 180
tttccatggg cgcctctttc gggctttccg tattggtctg gcaggacatt ctgggtatcg 240
agttgtactg gatggtgttg gcgatgtcgg tgatcctgct cctggcggtg ggatccgact 300
acaatctgct gctgatttcc cggttgaaag aggaaattgg ggccggattg aacaccggaa 360
ttatccgtgc catggctggt accgggggag tggtgacggc tgccggcatg gtgttcgccg 420
ttaccatgtc gttgtttgtg ttcagcgatt tgcgaatt 458




312


289


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






312
caggcatgca agcttggcgt gccgttccaa cccgaattgg ctttcggcgc catcggtgag 60
gacggcgtgc gggtgctcaa cgacgacgtc gtccgcggga cacacctcga tgctgccgcc 120
atggacgcgg tcgaacgcaa gcagctgatc gagctacaac gccgcgcgga acgcttccgc 180
cgcgggcgtg accgcatccc gttgaccggg cggatcgcgg tgatcgtcga tgacggcatc 240
gccaccggag cgacggccaa ggcggcgtgc caggtcnccc gggcgcacg 289




313


154


DNA


Mycobacterium tuberculosis



313
ggcatcttgg ccgccatgtt agccacactg ccaccggcta tagaagcgat gcgcaccgtc 60
ctgccagcac attgcggcgc tcctccctgg aaagcaagat aaccaagctc atgccgtggt 120
tgtgggtggc gtggtttggt ttgggtaact ttgg 154




314


324


DNA


Mycobacterium tuberculosis



314
tcggctaata atcgtcgacg ccggcctcct ctgcaatcgc cttggcggtc gccgggttgt 60
caccggtgat catcacggtg cggatgctca ttcggcgcat ttcgtcgaat cgttcccgta 120
tgcccacctt gacgatgtcc ttcagatgga cgacgccgat ggcccgcgcg ctgctgttat 180
cggtccattc cgcaacgact aggggtgtcc cccgccggag ctgatgccgt cgacaatggc 240
acccacctcc tcggtggggt gggcaccgtg atcgcgaacc cacttcatca ccgcagccgc 300
ggcaccttgc ggattcgacg gatg 324




315


322


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






315
ctcaagcttg gaggcgtggc gatcgcggtc caaggcgcgc tctccgagca caacgagcga 60
agacngctcg gcgacggagc ctttatcgac ntccgttcgg gctggctgac ggcggcnaaa 120
taatgctgga ctcgttgttg tcgacggtgc cgtggcgagc cgagcgccgt cagatgtacg 180
accgggtggt ctatgtgccg cggttggtga gtttccacga cctgaccatc gaagatccgc 240
cgcatccgct gctggcgcgg atgcgccggt ggctcaacta attctacggc ggcgaactgg 300
gtnatccctt cnccaccgtc gg 322




316


404


DNA


Mycobacterium tuberculosis



316
cctaggtcaa ccgtaccgtc atcggatcgg ggtcgaccgc acagatggac tggagcttcg 60
gcgaggtcat cgcctatgcc tcgcgggggg tgacgctgac cccgggtgac gtgttcggct 120
cgggcacggt gcccacctgc acgctcgtcg aagcacctca ggccaccgga aatcattccc 180
gggctggctg cacgactgcg acgtggtcac cctccaggtc gaagggctgg gcgagacgat 240
gcagaccgtc cggacgagcg gcactccttt tccgttggct cttcggccga atccggacgc 300
cgaacccgac cggcgcgggg tcaacccggc accgacgcgg gtgccgttta cccgcgggct 360
gcacaaatcc cgacgggtat gggctttgac ctgccgacgg ggga 404




317


346


DNA


Mycobacterium tuberculosis



317
agcttggcgt gacaccaaca cagggcactt aagatggcaa tgcgccgcct acctgcacgt 60
tttcgcgatg tcagaggatg ccgaggggag aacaatgcga gcacggccgc tgacgttgct 120
caccgctttg gcggcggtga cattggtggt ggttgcgggc tgcgaggccc gagtctaggc 180
cgaagcatat agcgcggccg accgcatttc gtctcgaccg caagcgcgac ctcagccgca 240
gccggtggag ctactgctgc gcgccatcac gccgcctagg gctccggcgg cgtcgccgaa 300
cgtcgggttt ggcgaactgc ctacccgggt ccggcaggca accgat 346




318


333


DNA


Mycobacterium tuberculosis



318
tcatgccgtt ggaccgacca tcggagttag ttgccgaacc gcgggaccac cgcaagcacc 60
cggtcctggt cgcgcaccgc gtcggccaac cgcttgagca ccaccacgcc gcagccctcg 120
ccgcgcacga atccatccgc gttggcgtcg aagctgttgc atcggccggt cggtgacagc 180
gccgaccact tggacagcgc gatggcggtg aacggtgaca aggtgagctg caccccgccc 240
gccaatgcca cgtcggtttc acgcaggcga agctctgaca cgccaagtga attgccacca 300
gcgacgacga acaagcggta tctacggcga tgg 333




319


207


DNA


Mycobacterium tuberculosis



319
gggtcgactt tctgcaaggc gaggctacac cgtcgtcgtc gtggtatgcg atagccatcc 60
cgtcgggcta ctcgccatca ccgatcagct tcgccccgaa gccgccgtgg tgatttccgc 120
tgcgaccaaa ctgaacgggg ccaaaccggt attgcttacc ggcgacaacc gggccaccgc 180
cgatcggctc ggtgttcagg ttggcat 207




320


250


DNA


Mycobacterium tuberculosis



320
aatccgaaat cctgaccgat acttgaacct ggtctcgttc ggcaataact cgtcggcgtg 60
caggacgcgg cgcaaacgta cttcggcatc aacgcgtccg acctgaattg gcagcaagcg 120
gcgctgctgg ccggcatggt gcaatctaac agcacgctct tcccgtacac caaccccgac 180
ggcgcgctgg cccgggcgga acgtggtcct cgacaccatg atcgaaaaac cttcccgggg 240
aggcggatgc 250




321


365


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






321
ttccgaattt cgggtccngg tcatatgacc ctcatggaag aagaagcggc cgccccgcgc 60
ccgtgcgacg gcgaatgaaa accctcaccc aggccgcatt gaacgccgac aagacggtgg 120
agcaggtcga agacgtcctg gacggtctgg gtaagaccat ggccgagctg aacagctcgc 180
tgtcacagct gaacagcacc gtggagcgct tggaggacgg tctggaccat ctcgaaggta 240
ccctgcacag cctggacgat ctcgcgaaac ggctcatcgt gttggtcgag ccggtggaag 300
ccatcgtcga tcggatcgac tacatcgtga gcctcggcga aacggtgatg tcaccgctgt 360
cggtc 365




322


413


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






322
nctcgatctt ggggtacgtt cgatgaggct gctgaccaac aacccggcca agcgggtggg 60
actggatgga tacggattgc acatcatcga gcgcgtgccg ctgccggtgc gggccaacgc 120
ggaagaacat ccgttacctg atgaccaagc gtgacaaatt ggggcacgac ttggctgggt 180
tggacgattt tcacgaatcc gtgcatctgc ccggagaatt cggcggtgcc ttgtgaaggt 240
ggcgccgggg tgccggatct gccgtcgctg gatcgtctgg tgtgcggctg gcgattgtcg 300
ccagcagctg gcacggaaag atctgcgacg cgctgttgga cggcgcccgc aagtggccgc 360
cgggtgtggc ctcgatgacc gactgtggtt cgggtgctcc gcgcgatcga tat 413




323


364


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






323
tcatcccgac caaaacgcga gctaggtcgg catccgggaa gcatcgcgac accgtggcgc 60
cgagcgcgct gccggcaggc cgattaggcg ggcatattat cccgccgcgg ctcccggctc 120
cgagtacggc gccccgaatg gcgtcaccgg ctggtaaccg ctcttgcgcg cctgggcggc 180
ggcctgccgg atcaggtggt agatgccnac aaagcctgcg tgatcggtca tcaccaacgg 240
tgacagcagc cggttgtgca ccaagcgcga acgccacccc ggtctccggg tctgtccaac 300
cgatcgaccg cccaagccca catgaacaaa ccccggcatc acgttgccga tcggcatacc 360
gtga 364




324


488


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






324
ttggcgggtt ggcccagcag cccgccggtg acggcgacga tgctgggctg gttgcggccc 60
tgcgccaccg cggcttgcat gctggttggc tgtcttggga cgatcccgaa atagtccacg 120
cggatctggt gattttgcgg gctacccgcg attaccccgc gcggctcgac gagtttttgg 180
cctggactac ccgcgtggcc aatctgctga actcgcggcc ggtggtggcc tggaatgtcg 240
agcgccgtta cctacgtgac ctgatggatc ggggggtgcc gaccgtgccc ggcgatgtgt 300
atgtgccggg anagccggtc cggttgccac gcaaaggcca tgtcttcgtc ggtccgacca 360
tcggtaccgg gacacggcgc tgtattgccc ggttcgctgc cgagttcgtc gcgcaactgc 420
acgcnggcgg gccagcggtg ctcgttcanc ccggaggttc cggtgacgat gatcgtgttg 480
gtctccct 488




325


396


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






325
gtaggagaga acaaagaccg tcgataggac acgtgttacg ccggtagctg tcattggtat 60
ggggtgccgc tgccgggggg catctactca cccgatcggt tgtgggaggc gttgctgcgg 120
ggcgacaatc tggtcaccga gatccccgcc gaccgctggg acatctacga gtactacgac 180
cccgaacccg gcgtgcccgg acgcaccgac tgcaaatggg gcgcgtacct cgataacgtc 240
ggcgactttg atcccgagtt cttcgggatc ggggagaaag aaacgatagc gatcgatccg 300
cagcaccgct tgttgctgga aacctcctgg gaagccatgg aacacggcgg gctaacaccg 360
aaccatatgc ctcccgacan gggttttcgt ggggtt 396




326


394


DNA


Mycobacterium tuberculosis



326
cgaactgagc ccatagaaag gcagcgacta attcgctggg caaataggaa gaccctttgt 60
cctgccacgt atatttgtcg acctcgttgc gaaggaagcg gctgcgattg gtgccctttt 120
ccctggagaa tctctgcccg gagcaggaag tcttatgagt tgacaagcag gggcgccgcc 180
ttcgccggaa atcacattct tggtctcgtg aaatgagagc gctcccaggt cgccgatgct 240
gccgagcgcc cgcccacgat acgacgccat cgcgccttgg gccgcgtctt cgaccaccgc 300
caggttgtgg tgcgtggcga tcttcatgat cgcgtccatc tcgcaggcca cccggcatag 360
tgaacgggga ccatggcctc ggttcgcggg tgaa 394




327


140


DNA


Mycobacterium tuberculosis



327
cttagacgcc acctccgggc cgagctccac ggggtggata agtacggccg gatgtggccg 60
caatgggaag ttgttgcccg cttgactgtc cgggttaacg ccggattcca ccacatcccc 120
ttgcgaaagg ccgttgggtt 140




328


242


DNA


Mycobacterium tuberculosis



328
gatcgcgatc gtcgatgtgg ccatccggct tggcgtcgac ccgcgtaagg cagaccagat 60
ggttcgcggc acggtcaacc tgccacacgc actggtaaga ctgcccgcgt cgcggtattc 120
gcggttggtg aaaaggccga tgctgccgtt gccgcggggg ctgatgctgt cggatcgacg 180
atctgatcga gaggatcagg gcggctggct ggaattcgat gccgcgatcg cgataccgga 240
tt 242




329


220


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






329
agcttacgcc gctttcgctt cngatttggg acgccgcatc gaaagcgcag ttggaagcgc 60
ggcgcccggc tggtcgagct gctcaagcag ccgcaatccc agcccatgcc cgttgaggag 120
caagtggttt cgatcttcct gggcaccggc ggtcacctgg actcggtgcc cgtcaaggat 180
gtcggcggtt cgaaaccgaa ttactggacc acatgcgggc 220




330


328


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






330
cgacgggacc tcgtcgcatc ttccatagcc cgccacacct tcagttgctc accggaatcc 60
aaccggtata aggtcggcga agcgctcggc attggtcatc gggatatgcc gctcgggacg 120
gtcagatgcc ctcgggtccn gccagcactc ctcaggcttc gtcggggtgg tcgcgaccgc 180
atgggccaca tcgcattcac caggtctgcg cgaatcacca gcacgtanac ggttcctttc 240
ctaagcaaca ccgaaatttc aggacccgaa tgctccggga aaacatgtca cggtaagtcc 300
ggtattccgg gtaccggttg agcattga 328




331


366


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






331
cggcatcggt ttgggctgtc accagcagtt ggtagttctt cactactgtt gttcgagcgt 60
cgagccgccg cgcgtgtcga ggtcgccgga cgcgtacccg ccaggccggt cagggtgccc 120
ttccagtcca cgcngctgtg gtcggctaac cgcttatctt caatcgagac natcgccagc 180
ttcatcgtgt tggcgatctt gtccgagggc acctcgaacc ggcgctgcga ntacagccac 240
gcgatcgtgt tgcccttcgc gtcgaccatc gtcgataccg caggcacttg cccctcgagc 300
agctgggccg atccgttggc aacgacctca gaggcacgat tggacatcag ccctagcccg 360
cctgcg 366




332


407


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






332
ccgtcgangc cgccgacttg gcttgaccga caccaacatg gcctgagggt gttcaacaag 60
accgtggccg acgggctgaa catcaccatg agcggcatga gccacgccac cgagttcatc 120
atgttgatcg ccgaaaacca ttggcgggta gcggaagaac ggtcgaggtg ctctacaccg 180
agtattcgaa gtcgaaaggc caaccgctgc tcaacggcgt caacatcatt ttcgacgggt 240
ttctgcgagg gaggatgcca cgatgaactg gatccaggtg ctgttgatcg cgtcgatcat 300
cgggttgctg ttctacctgt tgcggtcgcg ccgaagcgcg cggtccgtgc ctgggtcaag 360
gtgggctatg tcttgttcgt gctcccggca tctatgccgt gctgaga 407




333


473


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






333
ttacacgncc tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac 60
acaggaaaca gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc 120
aagctttttg agcgtcgcgc ggggcagctt cgccggcaat tctactagcg agaagtctgg 180
cccgatncgg atctgaccga agtcgctgcg gtgcagccca ccctcattgg cgatggcgcc 240
gacnatggcg cctggaccga tcttgtgccg cttgccgacg gngacgcggt angtggtcaa 300
gtccggtcta cncttgggcc tttgcggacg gtcccgacgc tggtcgcggt tgcgccgcgg 360
aaagcggcgg gtcgggtgcc atcaggaatg cctcaccgcc gcggcactgn acggccagtg 420
ccgcggcgat gtcngccatc gggacatcat gctcgcgttc atactcctcg acc 473




334


305


DNA


Mycobacterium tuberculosis



334
caggcatgca agctttgtca caccaagtgt ttcgaccagg cgctccatcc ggcgagtgga 60
tactcccagc aggtagcagg tcgccaccac gctggtcagt gcgcgttcag ctcgcttgcg 120
gcgctgcagc agccagtccg ggaaatagct gccctggcgc agcttgggga tcgcgacgtc 180
gatggttgcg gcacgggtgt cgaaatcacg gtggcggtag ccgttgcgct gattggaccg 240
ctcatcgctg cgttcgcggt agcccgcccc gcacagggcg tcggcttcag cccccatcaa 300
ggcgg 305




335


432


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






335
agcttagcca gtttttctac tcttgggccc acacccacag tgcttcgacg gtacggtcac 60
ccatgatggc catccagttg gcatcggtga gctgataaat gccagctggt ttcgccaacc 120
cggtagcgat cttggcgcgc tgcttgttgt cactgatacc tatcgagcaa gacagcccgg 180
tttgcgacaa gatgactttt cggatctctt cggcgacttc gatggggtcg tcgggagtcc 240
cgggcgccac cgcgaggtaa gcctcgtccc agccccatac ctcgaccggg tatcccaggt 300
cgcgcaataa cgccaccacc tcctcggacg ccgcgttgta ggcggctggg ttcgacggca 360
agaagtggcc tcagggcatc gtcggcgcgg tcccaacggc ntgccggcgc gcacaccgta 420
ggcgcggggc tc 432




336


429


DNA


Mycobacterium tuberculosis



336
ccggcggaac tcagacgtgc tggtggtgcg gcatggcacc gcgggcagca aagcgcactt 60
ctccggggac gacagcaagc gaccgctaga caagaggggt cgtgcgcagg cagaagcgtt 120
ggtaccacag ctgctggcgt tcggcgccac cgatgtttat gccgccgacc gggtgcgctg 180
ccaccagacg atggagccac tcgccgcgga actgaacgtg accatacaca acgagcccac 240
cctgaccgaa gagtcctacg ccaacaaccc caaacgcggc cgacaccgag tgctgcagat 300
cgtcgagcaa gtaggcacac ccgtgatctg cacgcagggc aaggtcattc ccgatctgat 360
cacgtggtgg tgcgagcgcg accgtgtgcc cccgacagtc ccgcaatcgc aaaggcagca 420
cgttggtgt 429




337


94


DNA


Mycobacterium tuberculosis



337
gtatggtcag ctgtccatcc ggcgctgtcg gccgagctgc cagatctcgt cagccgtaac 60
cgggttgcgg gatccacgcg tgcgggttgt ctac 94




338


351


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






338
ccgactttcc gcgggtaccc gctcaacttt gtgtcnacct caacgccatt gccggcacct 60
actacgtgca ctccaactac ttcatcctga cgccggaaca aattgacgca gcggttccgc 120
tgaccaatac ggtcggtccc acgatgaccc agtactacat cattcgcacg gagaacctgc 180
cgctgctaga gccactgcga tcggtgccga tcgtggggaa cccactggcg aacctggttc 240
aaccaaactt gaaggtgatt gttaacctgg gctacgcgac ccggcctatg gttattcgac 300
ctcgccgccc aatgttgcga ctccgttcgg ttgttccaga angtcagccc g 351




339


152


DNA


Mycobacterium tuberculosis



339
gcaccgatgt cggcgagcac ttcgtcaact tccaggggtg cccgcaccaa gtatttcgac 60
gagtatttcc gtcgggccgc cgccgccggt gcgcggcagg tggtcatcct ggcggcgggg 120
ctgggactcg cgcgcgtacc ggctgcctcg gc 152




340


263


DNA


Mycobacterium tuberculosis



340
tgcacccaac ttactgagca tgctaacgct ggtcgtgcgg gtcttgttcc cgcgtgtcgg 60
cagggcacac gctcggggcg tagctgggag aggccccggt caagcccgga gagcagtgct 120
cagtccgcca gcttgaccga ctttcgatga gaacgcgctt ctcgccgtat tgaactggcg 180
tgctgacggt cgctgagcag cgctcgccga gtgcggccgc tgattctttc atcgagccag 240
gacgcgcatt cgtgttcggc cgc 263




341


249


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






341
agcttacggc cggtcgacgc gacgagtggt tcatgacacc acaaaccgtc aacgcctact 60
acaacccggg gatgaacgaa atcgtcttcc cgcagcgatt ttacagccac catttttcga 120
tccgcaggcc gacgaggccg ccaactacgg cgggatcggg gcgcgtgatc gggcacgatg 180
atcgggcacg gtttcgacga tagggcgcca aatacgangg cgacgcaatc tggtcnattg 240
gtggatcga 249




342


269


DNA


Mycobacterium tuberculosis



342
atgtcgtcac gtcaccacaa tcgcgaggac ccaatcatgc cgcccagggc ggccaaccca 60
atggtggccg cgaagcggca gctcgatcgc agcgcggagg tgccggccgc cagttgattc 120
acgaacaggg tgaggtcata ggcgggcagg atagtgacga acgcaagacc tatatctgcc 180
gtcggagtaa gaatcgagta gccggtcgac caacggaagc gaaagtgtcc gcgatgttga 240
tgagcgtcgc cggttgtggc ggcggtggc 269




343


336


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






343
agcttcacca gcgtgccgat gctgttcgcn acacctccct actatgcgca attcgccgac 60
acgggtggca tcaacacggg cgataaggtg gacatcgctg gggtgaacgt cgggctggtg 120
cgctcgctgg caatccgcgg caaccgcgtg ttgatcggat tctcgttgcc cggcaagaca 180
atcgggatgc aaagccgggc agcaattcgc accgacacca ttcttggccg taagaacctg 240
gaaatcgaac cccgcggttc ggagccgttg aaacccaacg gtttcctgcc gttggcgcag 300
aacactacgc cataccaaat ctatgacgcg ttcgtc 336




344


417


DNA


Mycobacterium tuberculosis



344
ctgccgcggt ggcggtcagc gcctggcaag tcaccgcacc gccgtccggt tcatcggcag 60
gctcccccga aaagggccct ggcaacagaa ggtgatcaat gagctcccgc agaccttcgc 120
cgatctggga ccgacatacg tgaagttcgg ccagatcatc gcgtccagcc cgggagcatt 180
cggtgagtcg ctgtcgcggg gaattccgcg gcctgctcga ccgggtgccg cccgcaaaaa 240
ccgacgaggt gcacaagctc ttcgtcgagg aactcggcga cgagccggcc cggctgttcg 300
cctccttcga ggaagaaccg ttcgcgtctg cgtccatcgc ccaagtgcac tacgcgacct 360
gcgcagcggc gaagaagtgt ggtcaagatc cacggccggg catccgccgc cgcgttt 417




345


405


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






345
gatcgtgccg gccccccggc ggcagtagca gatcagctcg tcgaaatcgc ggcaaccagt 60
ccagtcgatt tccatacggg cgccgtcaat caactctgcg aacatcgcga tcggcaccgg 120
aaaccggcga gccgcgtcag ccagcgcaac cagcaccggg atcggatgaa tcatcaatat 180
tatcaagtga tttcctgatg gcatcgagct cggtgatctt ggtctcgggg gccagctcgc 240
cgtcggcgac gtcgtcgatc cggcggccga gcgcatagac cgcaaatagt gccgctcgct 300
tttcgcgcgg caagagtcgg atgccgtaat atangtttct ggcggccgtg cgcgtgatcn 360
actcggtgat tcgatacgcc tgttcatctc ggtcatgccg tcctc 405




346


414


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






346
ggtggcgcaa tgaccgaaac caccccagcc ccgcaaaccc cggcggcccc ggccgggccc 60
gcacaatcgt tcgtgttgga gcggcccatc cagaccgttg ggcgccgtaa ggaggccgtg 120
gtacgagtgc ggctggtgcc cggcaccggc aagttcgacc tcaacggccg cagcttggag 180
gactacttcc caaacaaggt gcaccagcag ttgatcaagg cacccctggt caccgtggat 240
cgggtggaaa gtttcgacat ctttgcccac ctgggcggcg gcggcccgtc gggtcatggc 300
cggcgcgctg cgcctgggta tcgcccgggc attgattctn gtatcgccgg atgaccggcc 360
cgcgctgaat aangccggct tcttgaccgt gatccacgcg ccaccgaacg caaa 414




347


331


DNA


Mycobacterium tuberculosis



347
cacaatagat tactcaagct tcgaaccagc ggccttatca cgtatccccg ctgagacctt 60
gacccttagg gccgaagtga cttcgctgct gctatgccga cacccgattt ccagacgctg 120
ctgttacacg acggccgggc cggtggccac catcacgctc aaccgcccgg aacagctcaa 180
caccatcgtc ccgcccatgc ccgacgagat cgaggccgct atcgggttgg ccgagcgcga 240
ccaggacatc aaggtcatcg tgctgcgcgg tgccggccgc gccttctccg gcggttacaa 300
cttcggcggc gggttccaac attgggggca t 331




348


386


DNA


Mycobacterium tuberculosis



348
tcaggacgct tatggttggc agatggtcgc cctggcgtcg aatacgcgcg agcgcatgag 60
ctcaccggtt cggaacaacg tatcgaagaa cgtcgcactg ctggcagatg gtatctccga 120
tgtggttgta atttgtatcc caactctaac tgtgctatcg gatcagcgtg aatatcgaga 180
tattgcgaat gcgatgacag gccgccattc ggtttattcg cttacgcttc ccgggttcga 240
ttcgtctgat gcactgccgc aaaacgcgga tatgattgtt gaaaccgtat ctaacgcaat 300
tattgatgtg gtaggcggca gctgccgttt tgtgctgtcg ggctattcat cgggtggggg 360
tgtttggcta tgccctctgc tcccat 386




349


187


DNA


Mycobacterium tuberculosis



349
cgcagctgtc gccgatctgg tccggaatac ctagctccag gttctgagtg gagatgagtg 60
cggccatcga agtgttgtca atgtactcca ggatgtcagg tgccaggccg ctggcgagga 120
tcttgggcac cgccgccatg acttggtcga agtcggcgaa cggggcgagc acgctggcgt 180
cgtggtc 187




350


241


DNA


Mycobacterium tuberculosis



350
gtagttcgtt catccaaaca cagtgcggta ccggctcaag cggatcaccg acttcaccgg 60
gcgcgatccc acccagccac gcgatgccta tgtccttcgg gtggcggcca ccgtgggtca 120
actcaactat ccgacgccgc actgaagcat cgacagcaat gccgtgtcat agattccctc 180
gccggtcaga gggggtccag caggggcccc ggaaaagata ccaggggcgc cgtcggaccg 240
a 241




351


335


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






351
tccgctcgct tctccgagag gttgagtgcc aacgctctgc cgatgcccga agccggcccc 60
ggtgatgacg gcgaccttgc cttcgaatga gctcatttga ctactccccg tggttgtccc 120
tgcgattggt ggaggtggcc gcgcagcctt gccccgaggt cggcgatcgc gtctcgggct 180
tcggggagca gactgacctg cagatggaag tcgtgccaca tgcccgcgaa ccggcgatgc 240
tcgatgcttg ttttcgaagc ggcgcaggcg gtttcgatct tgtccgcgtc aacacngatc 300
ggatcgtcgc ccgcggtctg catgacgaat gggcg 335




352


441


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






352
atgggaggcc accgattacc atcttgcaca caccgattcc gggctattga tgtccacgtt 60
cggtccgcga accgcgctgt ggctgctgct ggccaaaggc ggaggcgata ccgaagtcag 120
tgcccaagct tgggttccac gctcgcgcag ccacgccgtc acctttccac gagacctcac 180
ctgccgatcc gaaatggaat cggccgtgac ggaattggcg cagcgaacac tcaacgaggt 240
ggtggcttcg tcgcgaaccg tcacccgagt cgcggtcacc gtgcgcacgg cgacgttcta 300
cacccgcacc aagatccgaa agctgcaagc tcccagcacc gatcccgacg tcatcaccgc 360
tgccgcccgg cacgttcttg aacctattcg agctggaatc ggccgtccgg ttgctgggaa 420
ttgcngttaa gaactgggcc t 441




353


332


DNA


Mycobacterium tuberculosis



353
gctttgcgcg cttctccgag aggttggagt gccaacgctc tgccgatgcc cgagccggcc 60
ccggtgatga cggcgacctt gccttcgaat gagctcattt gactactccc cgtggttgtc 120
cctgcgattg gtggaggtgg ccgcgcagcc ttgccccgag gtcggcgatc gcgtcgcggg 180
cttcggggag caaactgacc tgcagatgga agtcgtgcca catgcccgcg aaccggcgat 240
gctcgatgct tgttttcgaa gcggcgcagg cggttcgatc ttgtccgcgt caacgcagat 300
cggatcgtcg cccgcgggtc tgcatgaaga at 332




354


334


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






354
ctcacgcagc cacgccgtca cctttccacg aagacctcac ctgccgatcc gaaatggaat 60
cggccgtgac ggaaattggc gcagcgaaac actcaacgag gtggtggctt cgtcgcgaac 120
cgtcacccga gtcgcggtca ccgtgcgcac ggcgacgttc tacacccgca ccaacatccg 180
aaagctgcaa gctcccagca ccgatcccga cgtcatcacc gctgccgccc ggcacgttct 240
tgacctattc gagctggatc ggcccgtccg gttgctggga gtgcggttag aaactggcct 300
agaaaccggc gggcacaccg cacctgggcg gggn 334




355


341


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






355
tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca 60
gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc aagcttgatg 120
ccgccgaaac cgagcgtgag cacgccgcca gccaccacnc gcgggtcggg cgccgggccc 180
gggtcgccan gctgctccgc tcggtgatgg cacgccaccg cgacaccacc cggctgcgct 240
acgtcgagcc ataccgggcg gagctacatc ggctcggccg cccagtgttc gggccctctt 300
tcgaagtcga agtcgatacc gattgcgcat ccgcngccgc a 341




356


259


DNA


Mycobacterium tuberculosis



356
caggcatgca agcttcacgt ccgtacggct cgggtacgct tcggtcgcag tgtgcgagtg 60
atagatgacg accgggacct cgtctgcatc ttccatagcc cgccacacct tcagttgctc 120
accggaatcc aaccggtaga aggtcggcga gcgctcggca ttggtcatcg ggatatgccg 180
ctcgggacgg tcagaaccct cgggtccggc cagcactccg caggcttcgt cggggtggtc 240
gcgacgcgca tgggccacc 259




357


349


DNA


Mycobacterium tuberculosis



357
gcttgtctat cgtcccggcc aggtccggcc agtcaaggtc gaaggccagt ccggtctcct 60
ctccgactac ggccaagaac tgggcgacgg tgtcagtgca gaccagcgga aactggtggc 120
gccctaggcg agcgaccgcc tcacaaacgg cggtgaccgc gttctggtcg tgcaccatcg 180
agccgtgccc agcccggccg cgtgccgtca gccgcatcca ctggatgccc ttctcggcgg 240
tttcaatcag gtacaggcga cgttcgccac catcgtgccg gggcacggtt agcgagaaac 300
cgccgacttc acgattgcct cggtgatgcc gtcgaaacag atcgggcct 349




358


325


DNA


Mycobacterium tuberculosis



358
gcgcgccatg ttgaggttgt ccgacggtga cgacggtgaa ccacaactgt ttgacctgtc 60
cgcacacacc gtgtggatcg gcgagcggac ccgacaaatc gatggcgcgc acatcgcgtt 120
tgcccaggtg attgctaatc cggtcggggt caagttgggc cccaacatga ccccggaact 180
ggccgtggag tacgtcgagc ggctcgaccc gcacaataag ccgggccggc tgacttggtg 240
agcaggatgg gcaaccacaa ggtccgcgat ctgttgccac cgatcgtgga gaacgtccat 300
gccaccgggc atcaggtcat ctggc 325




359


191


DNA


Mycobacterium tuberculosis



359
ttgccttcca tgccgagcaa ggtcgactca gcgatgacga attgttcttc ttcgcgggtg 60
ttgctgctgg ttgcgggcta tgagagcact gctcatatga ttagcacatt gtttctgacg 120
ctggccgact atccagatca gctgacactc cttgcgcagc aaccagacct gatcccgccg 180
gcgatcgagg a 191




360


74


DNA


Mycobacterium tuberculosis



360
cgacgctggg cccaactgcg accaccaggt cctggtatgg caggacatgg ccgggttcag 60
cggcgccaat accg 74




361


312


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






361
taacgactcg ggtccagcga ccgcgccaac acnaacggcc ggacnacgtg ggccagggtc 60
gcggcctccc ctacaaacag gatccgttgc ctgcgaacga caggctccgg tgcggcgttg 120
ggcgccgtgc tcgtcccagc gtccggtccc gggtcgccgg cgacgcttgt ttcctccata 180
ctcgccccct aatctcgagg cagcccgtac ccgcaggcaa cctcccaaaa atgcaatccc 240
ccaaaatgca atgcgtcnag ctatttctca caccgaccgc tagttgcgga tcanaaatcc 300
gttgggcgcg ga 312




362


335


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






362
cntggcggtg ggtgcggtgt cgaacacgac cacacttctt tgcggttcgg tgatctcgac 60
accggccgcg agccgaccac catgcgcgcg tagatcggcg atcagcgcgt cggctatcgc 120
ctgggtgccg cccaccggaa tcggccagcc gaccgaatgg gccagcgttg ccatcatcag 180
tccggcgccg gccgacacca gtgacggcaa cggtgaaatc ncgtgggcgg caacgccggt 240
gaacaacgcg cgggcatcct cgcccgccag cgaccgccag gcaggggtgc cctgggccag 300
catccgcagc ccgagacnca ggaccgancc cagtg 335




363


386


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






363
gcttttcnga tcgcagcgag tcgtacccgc gccggtcacc ttcgtggata tcgccggcct 60
ggtcaagggg gcgtccgagg gagccgggct gggtaacaag ttcctggctc atatccgcga 120
atgcnacgcc atttgtcagg tggtgcgggt gttcgtcaac aacnacttga ctcatgtcac 180
cggacgggtc gatccccant ccgacattga ggtcgtcgan accgagctga tcctggcana 240
tctgcaaacc ctggagcggg ccacgggccg gctggagaag gaancgcgca ccaacaaggc 300
gcgcaagccg gtctacgacg cggcactgcg tgcccagcag gtgctcgacg ccggcaanac 360
gctgttcgcc gcgggggtgg atgccg 386




364


386


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






364
gtcgtacgcc attngtcggt gtgcgcatac cagtacgacg cgccgggcac ctgacgcggc 60
ggccgcgacc agtcggtggc catcgccatc gtctgccacc cggtcaacgg acgcaccttc 120
tcctggccga cgtagtgcgc ccacccgccg ccgttgcgtc ccatcnatcc ggtcaacatg 180
agcagcgcca acaccgagcg gtacatgaca tcgctgtgga accagtgaca gattccgccg 240
cccatgatga tcatcgaccg tcctccggat tcggtcgcgt tgcgggcgaa attccttggc 300
aaaccggatt gcctgcgcgg ccggcacacc ggtgatcgac tcctgccagg ccggggtgtt 360
ctgctgggtt cggtcgtggt accggt 386




365


335


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






365
gcgaggcggt atcgcttccc gtcgtaccgg cgaccgccag ccgagaagct cgttttccca 60
gtgttgctgg ggattctcac gctgctgctg antgcgtgcc anaccgcttc cgcttcgggt 120
tacaacgagc cgcggggcta cgatcgtgcg acgctgaant tggtgttctc catggacttg 180
gggatgtgcc tgaaccggtt cacctacnac tccaagctgg cgccgtctcg tccgcaggtc 240
gttgcttgcg atagccggga ggcccggatc cgcaatgacg gattccatgc caacgctccg 300
agttgcatgc ggatcgaata cnaattgatc accca 335




366


396


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






366
tgggtcttgc cggcgagccc agcgaagtcg ctagcgtggc cgtgtttctt ggcttcggat 60
ctatcctcgt tacatgaccg gcaccgtgtt ggacgtgact ggcggccggt tcatatgaca 120
ccgagatcat tgccacggta cggcaattcg tcaagaagga aatctttccc natgcaccgg 180
ccctcgaacg tggcaacagc tacccgcaag aaatcgtcga tcggctgggt gttattggct 240
tgctcggtcg ccggctgcaa gggtatcgac accaccgagt tcattctcgg gcgtgccggc 300
gcattcgagc tggcggtgcg cgctgcccag caccgtcata agtacttgan gatggtcaaa 360
cgtcggacga accgccacca cgtcgctgcc gaacgg 396




367


262


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






367
tagatgccca agcttgccnt tanagacctc gtcgaccaag cacggacgcg accgtcgaag 60
gtggcgaatc cgggcttggc gtcnacccgc gtaaggcaga ccagatggtt cgcggcacgg 120
tcaacctgcc acacggcact ggtaagactg cccgcgtcgc ggtattcgcg gttggtgaaa 180
aggccgatgc tgccgttgcc gcgggggcgg atgttgtcgg gagtgacgat ctgatcgaga 240
ggattcaggg cggctggctg ga 262




368


303


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






368
tctccacggc gtggatcaag gtaccggccg ggatgttgcg caatggcagg ttgttgcccg 60
gcttgatgtc tgcgttagcg ccggattcca ccacatcccc ttgcgaaaag tccgttgggt 120
gcaatgatgt agcgcttctc cccatcgaga tagtggagca acgcaatccg tgcggtacgg 180
ttcgggtcgt actcgatgtg cgcgaccttg gcgttgacac catctttgtc attgcggcga 240
aagtcgatca tccggtaagc gcgcttatga ccgccgcctt tgtgccgggt nggtaatccg 300
gcc 303




369


367


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






369
gcccggttcg atcgggcatg tccgcagtcg tcgttaccgg aggcggtcgt ggccgcgcta 60
atcggcgtcg gcgccgacaa gatgtgggat atccgcaatc ggggcgtcat ccctgcgggc 120
gcgctccccc gcgtccgagc cttcgtcgac gcaatcgagg caagtcacga cgcggatgag 180
gggcagcagt gaattacagc gaggtcgagc tgttgagtcg cgctcatcaa ctgttcgccg 240
gaaacagtcg gcgaccgggg ttggatgcgg gcaccacacc ctacggggga tctgctgtct 300
cgggctgccg acctgaatgt nggtgcgggc ancgccggta tcnactcccg tggaacacag 360
ccggggc 367




370


366


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






370
ctcggcgtgg atatcggtgt agccggcgcc ggtgaangtc ggctccttac gtccactcga 60
caacagctca tagcgatcca accagtangc aaccgccttc agcagtacaa ccgcgccggc 120
gaacactgcg agttgaacgc gagctgcctg ggtcagcatg cctctgccgg ttgtcagccg 180
aaggccgccg aacaggtaat gcgtcaacag gctcgctaga aacgccagaa ccacggccac 240
gaacagccag ttcagcaccg accggtagaa cggcagatcg aagacgaaaa aacccaatgt 300
catagccgaa ttcggggtcc acgatgccaa aggtgccccc gtgtacaaca actgaacctt 360
caccca 366




371


455


DNA


Mycobacterium tuberculosis



371
tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta 60
tgaccatgat tacgccaagc tatttaggtg acactataga atactcaagc ttcacgtccg 120
tacggctcgg gtacgcttcg gtcgcagtgt gcgagtgata gatgacgacc gggacctcgt 180
cggcatcttc catagcccgc cacaccttca gttgctcacc ggaatccaac cggtagaagg 240
tcggcgagcg ctcggcattg gtcatcggga tatgccgctc gggacggtca gagccctcgg 300
gtccggccag cactccgcag gcttcgtcgg ggtggtcgcg acgcgcatgg gccaccatcg 360
cattcaccag gtctgcgcga atcaccagca cgtagacggt tcctttccta agcaacaccg 420
aagtttcagg accgaatgct ccgggaaaca tgtca 455




372


196


DNA


Mycobacterium tuberculosis



372
caggcatgca agcttgatgc cgccgaaacc gagcgtgagc acgccgccag ccaccacgcc 60
cgggtcgggc gccgggcccg ggccgccagg ctgctccgct cggtgatggc acgccaccgc 120
gacaccaccc ggctgcgcta cgtcgagcca taccgggcgg agctccatcc gctcggccgc 180
cagtgtccgg gccctc 196




373


443


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






373
cctgcatccg gctcgtatgt tgtgtggaat tgtgancgga taacaatttc acacaggaaa 60
cagctatgac catgattacg ccaagctatt taggtgacac tatagaatac tcaagcttcc 120
aatccccctg ccctgatacg cgtcggcaac cgtgaacgcg atctcggcga ccgtcggatc 180
ggtttcatcc cgcacaaaac gcgcgtcggc tacggggtcg cttccgtcgg tcaccaccca 240
gacgaagtgg tcgacgtagt cgacttccga caggtagtgc atcaacgccg gactgggaac 300
acnagccgac atgaaccgtc gatacagcgt ctcnccggag aactggatgt gtccgtgcac 360
ggtccgctcg cggtcaccgg gcagcacggg gcgtaacatc agttgagtcc cgtcggcaag 420
ccgtaccgga atcggggaga cga 443




374


445


DNA


Mycobacterium tuberculosis



374
caagatgatc gccggtgcca ccccgatccg tgcctcggtc agcgcgaacg tgctttccgg 60
tccggcgacc accatgtcgc acgcaccgac caggccgaac ccgccggccc gcacatgccc 120
gttgatggcg ccgaccaccg gcagcggcga ctcgacgatg gcgcgcaaca gcgccgtcat 180
ttcccgcgcc cgcgccaccg ccatccggta cggatcacca ccaccaccgc cggcctcgct 240
gaggtccgcg ccggcgcaga acgttccgcc ggtatgcccc agcacgacca gccgcaccgc 300
cggatctgct tcggccgcac tcagcccttg atgtagttgg ctgaccagcg tgctcgacag 360
cgcgttgcgg ttgtgcggag agttcagtgt cagcctggcg aaggggccgc cgcaggcggc 420
cgggccagcg tagtcgacgg ggctg 445




375


308


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






375
ctcaagcttc gatcgacagt actcccgcct tgggtctggt cttcgagctg gtcggtcatg 60
gtcggacctg ctggtagtgg ggatctaacg caacatggtc gggattcatc atggtgtacc 120
cgtgataccc attcgcagct gccggtgaaa ccccgcgatg ccgggatttc cagccgcact 180
aggatgtcta gccggccagc cgctgccgcc ggacttcggg atgttcggta taccaccgat 240
cggcaatctt gcntatccgc cgatgctcga acgctagcca ccccaaacca accactgtga 300
cnacaatc 308




376


239


DNA


Mycobacterium tuberculosis



376
tgaatttccc gatcccacaa tctcggttca gatacaggtc gccatacccc ttacttcggc 60
aacgctgggc ggattggccc tgccgctgca gcagaccatc gacgccatcg aattgccggc 120
aatctcgttc agccaatcca tacccatcga cattccgccg atcgacatcc cggcctccac 180
tatcaacgga atttcgatgt cggaggtcgt gccgatcgat gtgtccgtcg acattccgg 239




377


431


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






377
tactcaagct tgaacgctgc gagcgagccc atgtagagcg tttggtacca aaccgatcgg 60
tgggccaact tgccatgggc tcacagcggc tatcgcgagc gtgtagccga tcatcggcca 120
ggcgacggtg gcctgagcgg caggggttgc cttatccatc ctcttgcggc atggttgccg 180
cagggagtgc cggtaagtct ggtcggcaac ctggcccgct gcgggttggg ttcggattcc 240
ctcggctagt aaggtgctcg cctggtgtta caacgaatcg ctagacagct cttatcggga 300
gtggccgtcg cgatcgttgc gctgccgctg gcgatcgcgt tcggcnttac cgccaccgga 360
acgtcccaag gtgcgctcat cgggctctac ggcgccatct tcgccggatt cttcccngcc 420
gtgttcggtg g 431




378


334


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






378
gcggtgtctg aacttcgccc gttccctcca gcgcattgag cttcagcccg accggcaggt 60
agggagtcgg catgcggtcc ttcgccccga ccccgctggc taaatagcca cccccgagcg 120
cggtcacggt ctttgcaccg ggacgacggc ataccggcag cgcgaacatc gccgcgggct 180
gcagcgtgaa cgtcgaatac gagtcgaaca gtgtcggcgc gtaaaaaccc gagccggcgg 240
tcgcttcggt aatcaacggc tcctgcgcaa ccagctgcaa ntcnccggtg ccaccggcgt 300
tgacaatctt gatntcggcg acctcgcgca ccan 334




379


302


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






379
tactcagctt cggctcaggt ggtgctgctg gtaaagttcn ctgaacggtg caggtttcga 60
caatgtggtg ccggttcggc gggtactgcc atcgagacac tggcgcaggc tatcgcaccc 120
gttatcggct acaaacaaat cgcggtatgc gttcttgagc atgagtcggc gaccgtcgtc 180
atggtcgaca cccacgacgg aaagacgcag atcgccgtca agcntgtgtg ccgcggatta 240
tcaggactga cctcctggct gaccggcntg tttggtcncg atgcctggcg cccggccggc 300
gt 302




380


240


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






380
catcacctgg ttcatgaaac tggaagcagc gcagcgcttc cttttcggcc gcaacatgag 60
ccagcctctc gtcggcggtc gggtgcaggt gctcgggcag ctcggccgcg acagccgcct 120
gaccctgaaa ccagcttcca tatcccgcga cgaacgacgc cagtccgcta cgtaacccct 180
ccgcgactgt ccatggacaa cancgcgttc tccaccgacc gggcccgggt gtggggtgtt 240




381


362


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






381
ctcaagcttc ccggcggcca gtaccgaaag cgcgaacagc tcgcggcagc ccacaacntg 60
ctgcgtcgga ttgccggcgg cganatcaat tccaggcagc tcccggacaa tgcggctctg 120
ctggcccgca acgaaggact cgaggtcacc ccggtgcccg gggtcgtggt gcacctgccg 180
atcgcacagg ttggcccaca accggccgct tgatgcccgg tcggcaagcc cggcagttgc 240
caaacccagc gtgatcaggc tcggctcgcg agttcggcga agaagtggct cgcctgatca 300
cctaccatcg gccaggatct gcgtgtcatc acnacgctcg ccaaggaggt tgttgtggtg 360
ct 362




382


411


DNA


Mycobacterium tuberculosis



382
gccacgtttc gcgccgcccg gcatacggcg gcgtaccgat ctccgcgtca tacacccgcg 60
ggtaatcgcc gacggtgccg gttcgcgagc cgaaggtgac gacgctgatt gaatcgagtt 120
ccaggtccag cgggtggcgc agcaacggcg cgagctcaac gacgtcaatc acgttgtcgc 180
tttctacggt caccgacccg gtgaccgtag tcgcccggtg cgctcggccg agaagttgca 240
ccgccaccac cgcgacaccg tcttgcacgc ggacgccacc cccggatcgg ttgttggcca 300
aggtaattgg gtcattccat ttgacgggac gccgaccccg cagccccagt accgcccacg 360
accacgccgg ctgaccccac cactgtacga acaccaaggc gacgccgacc a 411




383


331


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






383
ctcaagcttg atgccgccta aaccgaagcg tgagcacgcc gccacccacc acgcgcgggt 60
cgggcgccgg gcccgggccg ccaggctgct ccgctcggtg atggcacgcc accgcgacac 120
cacccggctg cgctacgtca agccataccg ggcggagcta catcggctcg gccgcccagt 180
gttcgggccc tctttcgagg tcnaggtcna taccgatttg cgcatccgca gccgcaccct 240
ggacgacaga accgtgccct acgagtgctt gtcgggcggg gccaaagaac ancttggcat 300
cctggcgcga ttggccggcg cggtcctggt c 331




384


254


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






384
ctcgggtacg cttcggtcgc agtgtgcgag tgatagatga cgaccgggac ctcgtcggca 60
tcttccatag cccgccacac cttcagttgc tcaccggaat ccaaccggta naangtcggc 120
gagcgctcgg cattggtcat cgggatatgc cgctcgggac ggtcagagcc ctcgggtccg 180
gccagcactc cgcaggcttc gtcggggtgg tcgcgacncg catgggccac catcgcattc 240
accaggtctg cgcg 254




385


346


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






385
ctcaagcttc aattcctcca cgacgcgttc ccaaatgaat ttcccgatcc cacaatctcg 60
gttcagatac aggtcgccat accccttact tcggcaacgc tgggcggatt ggccctgccg 120
ctgcagcaaa ccatcgacgc catcgaattg ccggcaatct cgttcagcca atccataccc 180
atcgacattc cgccgatcga catcccggcc tccactatca acggaatttc gatgtcggag 240
gtcgtgccga tcgatntntc cgtcnacatt ccggnggtca ccatcaccgg caccagnatc 300
gacccgattc cgctgaactt cgacgttctc agcagcgccg gaacca 346




386


287


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






386
ttaacccccg tggcctctac gccgcctncg ggtcgaacat gcatcccgag canatgctcg 60
agcgcgcacc ccactcgccg atggccggaa ccggctggtt acccgggtgg cggctgacgt 120
tcggcggcga ggacatcggc tgggaagggg cgcttgccac cgtcgtcgaa gacccagatt 180
cgaaggtgtt cgtcgtgctc tacgacatga ccccggcgga cgagaagaac cttgaccggt 240
gggaaggctc cgagttcggc atccaccana agatccgatg ccgcgtt 287




387


370


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






387
ctcaagcttg attttgatca tcatggatga tcatcacccg aagtgtggta gccgcagtgg 60
ttatcgtggg taccgtcgtg ctttccatgg gcgcctcttt cgggctttcc gtattggtct 120
ggcaggacat tctgggtatc gagttgtact ggatggtgtt ggcgatgtcg gtgatcctgc 180
tcctggcggt gggatccgac tacaatctgc tgctgatttc ccggttgaaa aangaaattg 240
gggccggatt gaacaccgga attatccgtg ccatggctgg taccggggga gtggtgacgg 300
ctgccggcat ggtgttcgcc gttaccatgt cgttgtttgt gttcagcgat ttgcgaatta 360
ttggtcagat 370




388


330


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






388
cgnccaaccc gaattggttt tcggcgccnt cggtgaggac ggcgtgcggg tgctcaacga 60
cgacgtcgtc cgcgggacac acctcgatgc tgccgccatg gacgcggtcg aacgcaagca 120
gctgatcgag ctacaacgcc gcgcggaacg cttccgccnc nggcgttacc gcatcccgtt 180
gaccgggcgg atcgcggtga tcgtcgatga cggcatcgcc accggagcga cggccaaggc 240
ggcgtgccag gtcgcccggg cgcacggtgc ggacaaggtg gtgctggcgg tcccgatcgg 300
cccanacgac atcgtggcga gattcgccgg 330




389


346


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






389
cgtgactgcc accggggcca ctccgcagaa tctgtacccg accaagatct acaccatcga 60
atacgacggc gtcgccgact ttccgcggta cccgctcaac tttgtgtcna ccctcaacgc 120
cattgccggc acctactacg tgcactccaa ctacttcatc ctgacgccgg aacaaattga 180
cncagcggtt ccnctgacca atacggtcgg tcccacgatg acccantact acntcattcg 240
cacgganaac ctgccgctgc tagagccact gcgatcggtg ccgatcgtgg ggaacccact 300
ggcgaacctg gttcaaccaa acttgaaggt gattgttaac ctgggg 346




390


355


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






390
tcgctcaagc gcntgaggcc gaancggctg gttacgactc cctgtttgtg atggaccact 60
tctaccaact gcccatgttg gggacgcccg accagccgat gctggaggcc tacacggccc 120
ttggtgcgct ggccacggcg accgagcggc tgcaactggg cgcgttggtg accggcaata 180
cctaccgcag cccgaccctg ctggcaaaga tcatcaccac gctcgacgtg gttagcgccg 240
gtcgagcgat cctcggcatt ggagccggtt ggtttgagct ggaacaccgc cagctcggct 300
tcgagttcgg cactttcagt gaccggttca accggctcga aaaggcgcta canat 355




391


403


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






391
atactcaagc ttccgctggg gcctgttcaa ccatggcgat cccgttggtc ccggacatcc 60
cgaacgagga caccgcgacc cncttcggtg tgtgatcatt accgttgggc cactgcgtaa 120
ccgcttgcgg cacaaagagc ccggtctcga cgtcggaaag ctcatcgggc acccgattga 180
aatgcagcag cggcggcacc accccgtgcc gcagtgacag aattgccttg atcagcccga 240
cggtccccgc cgatgccgtg ctgtgcccca tgttgctctt ggccgatcca agcgcgcagg 300
gggtgcccgc gccatacacc cgcgccaggc tgcggtactc aatcgggtcg ccgattggcg 360
taccggtgcc gtgcgcctcc accacaccga ccgtttcggg ctg 403




392


440


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






392
caacagcgtt ccagcggcat accaccgcac atgccgtgca cccggcgccg ggcggagtcg 60
ccgcataaca cangtacacc ttgggaatcg gtgtgcgcca gggattcnac cgcggggtgg 120
ggccggcgat cgcgcgccag gtcgagttgg cgccgaccgt gatntcaccg ccgacgtagt 180
tggcgttgtg gtccgccatc cgcgcggcgg gcacggcgcg ggccgccacc acgatgtcac 240
ggaagccggg ggcgaacgct cgacgacctg gttaccgtct cngtcgcntc nancgtggac 300
ccgacngcac gtgggcatat gtccanaacg gacgnggccg gtttcntcga tgcngccggg 360
gtccgcgacn tgcggacncn cngncacacc atccgccagt ccgcgtggcg tcccgccgcg 420
actctgcctc ggccgcgcca 440




393


353


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






393
ctcaagcttt gncgacgatc gggcgatgtc gatganagga aaccccagcg cacaaccgac 60
nattttggcg tagccggcgg acntctgctc gattccgatc acgtcggcgc tcgcatcgag 120
catggcgccg gcgacggcta gcagcgatcc gccgtcgtcg aggaacacga cacgagccgt 180
acgcccggcc gtaagccgcg cccaggattc ggcgaaaaac cgttctacgt ggcgggtgta 240
ctgggtgtcc aatgattcgt ggggtgcgta ggcgtcgctg caatcgtcga cataaatgcc 300
gtcggcccgc atcgcgtcaa caactcccgg gtgagtggaa tancacttgc cga 353




394


340


DNA


Mycobacterium tuberculosis



394
tccaacgcgg tgacagattt gtctatcctg gacctgacgg tgaggtcgaa gttttccagg 60
aattcggcaa aatcggtaag agcctgaaga attcggtatc gccggacgaa atctgcgacg 120
catacggggc agatacgctt cgggtttacg agatgtcgat ggggccgctg gaggcttcac 180
gtccatgggc cacaaaggat gttgtcggcg cgtaccgttt tctgcagcgg gtgtggcgct 240
tggtcgtcga cgagcacacc ggcgaaactc gggtggctga cggcgtggaa ctcgacatcg 300
atacgctacg ggcgttgcac cgcaccatcg tcggcgtgtc 340




395


362


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






395
ctcgtccttg actacgccca gtatcgaaan cctcctgtgc cggtncgcta aacacccggc 60
ggacactcan acggtgctgg tggtgcggca tggcaccgcg ggcagcaaag cgcacttctc 120
cggggacgac agcaagcgac cgctagacaa gaggggtcgt gcgcaggcag aagcgttggt 180
accacagctg ctggcgttcg gcgccaccga tgtttatgcc gccgaccggg tgcgctgcca 240
ccanacnatg gagccactcg ccgcggaact gaacgtgacc atacacaacg agcccnccct 300
gaccgaagag tcctacgcca acaaccccaa acgcggccga caccgagtgc tgcagatctt 360
cg 362




396


356


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






396
gtatcgcctc cncctttggc caccagcagc cacagcgcgg ttcgcggacc gaacgtggac 60
atcaatagcc cggaatcggt gtgtgcaagt tggtaaacgg tgttgatccc aagctttgcc 120
agccttttcg tagtcttggg ccccacaccc cacagtgctt cgacggtacg gtcacccatg 180
atggccatcc agttggcatc ggtgagctga tagatgccag ctggtttcgc caacccggta 240
gcgatcttgg cgcgctgctt gttgtcactg atacctatcg agcaagacag cccggtttgc 300
gacaagatga cttttcggat ctcttcngcg aacttccaat gggggtctcc gggant 356




397


350


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






397
ctcaagcttt tggtctagcc ggccgagcac gatacgggtg tccttggcca ccggcggcgg 60
ctgtccggga aatggcgggt ccccggtggt tttgctgang antgctgaac cgtagtcgaa 120
gtgggcggcg tcagactcca cccagccagc aggcagcgcg aagctgaatc ctccaaccgg 180
gttgtcgatc cggacaggtt ggggtgcgtt tggggcaatg acaggtggcg gcggtgcgtt 240
cgggtcggcc ggcggaggtg ctgcgttggg atcncccggc tgggcattcg gcntnttggc 300
ggcggccggt ggtggggggg caacangtgt cccggtgcgg gtggcgctgc 350




398


355


DNA


Mycobacterium tuberculosis



398
atctgtaccc gaccaagatc tacaccatcg aatacgacgg cgtcgccgac tttccgcggt 60
acccgctcaa ctttgtgtcg accctcaacg ccattgccgg cacctactac gtgcactcca 120
actacttcat cctgacgccg gaacaaattg acgcagcggt tccgctgacc aatacggtcg 180
gtcccacgat gacccagtac tacatcattc gcacggagaa cctgccgctg ctagagccac 240
tgcgatcggt gccgatcgtg gggaacccac tggcgaacct ggttcaacca aacttgaagg 300
tgattgttaa cctgggctac ggcgacccgg cctatggtta ttcgacctcg ccgcc 355




399


360


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






399
ctcaagcttg caatgcgggt cgggatgccc atggttggaa natggtcgcc ctggcgtcna 60
atacgcgcga gcgcatgagc tcaccggttc ggaacaacgt atcgaaaaac gtcgcactgc 120
tggcagatgg tatctccgat gtggttgtaa tttgtatccc aactctaact gtgctatcgg 180
atcagcgtga atatcganat attgcgaatg cgatgacagg ccgccattcg gtttattcgc 240
ttacgcttcc cgggttcgat tcgtctgatg cactgccgca aaacgcggat atgattgttg 300
aaaccgtatc taacgcaatt attgatgtgg taggcggcag ctgccgtttt gtgctgtcgg 360




400


272


DNA


Mycobacterium tuberculosis



400
caaatacacg ccggacgcac aggcggacat cgccatcccg agcacaccca aaacgggata 60
caggatggag gccaacgcca cggccgcgcc caggatcacc aaccacaccg gcttggtcag 120
cttgtcggcg gcggtatagg catcgggccg ctgcaacgca gcatgcacaa acgcgtacac 180
cgctgtcacc aagacggcga ccagcaatac cagcatgacg gtacccacga ggtggctcac 240
gcattcagac tatgcggttt gcatccaaca cg 272




401


306


DNA


Mycobacterium tuberculosis



401
ctcgtccttc ggcctcgctg caggagtggg agccgcaggg ctggaaatcc gaaaaacgag 60
ccggtgatcg cactgtcgcc gatcggcgcc gcacctggtt ggtgttacgg atgaatccgc 120
agcgaaatgt ggctgcggtg gcgtgtcgtg actcgttggc gtcgacgctg gtggcagcca 180
ccgagcggtt ggtccaggat ctggatgggc aaagttgtgc ggcccggccg gtgacggccg 240
atgagctgac cgaggtcgac agcgccgtgt tggctgactt ggaaccgaca tggagtcgcc 300
ccggtt 306




402


300


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






402
gtctagnccg ccgaacacga tacgggtgtc attggccacc ggcggcggct gtccgggaaa 60
tggcgggtcc ccggtggttt tgctgaagan tgctgaaccg tagtcgaagt gggcggcgtc 120
agactccacc cagccagcag gcagcgcgaa gctgaatcct ccaaccgggt tgtcgatccg 180
gacaggttgg ggtgcgtttg gggcaatgac aggtggcggc ggtgcgttcg ggtcggccgg 240
cggaagtgct gcgttgggat cgcccggctg ggcattcggc gtgttggcgg cggccggtgg 300




403


396


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






403
actcaagctt gagattggcg tcaacgggtg tcggcaccgg cgtcctgcag ttggtaggcc 60
tgcagtttgt gcatcaggcc gatgccgcgg ccctcgtggc cacgcatgta cancaccacg 120
ccgcgcccct cacgggcgac catcgccagc gcggcgtcca gctgaggccc gcaatcgcag 180
cggcgtgacc caaacacatc gccggtcaag cactccgaat gcacccggac cagcacgtcg 240
tcaccgtcgg cgttgggccc ggcgatctcg ccgcggacca gcgcgacatg ttccacgtcc 300
tcgtaaatgc tggtgtancc gatggcgcga aactccccat gacaantcgg aatcccgcgc 360
ctcggcgacc ccgctcaatg ttgcttctcn tgcttg 396




404


352


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






404
tcgacnagca ttcttgacng ttgttttggc tcggcatggt tagccaaggt tctgcggtcc 60
caccagatca tcttggtccg gtagcgctcg tccgggtatg ctgccgccgg gattctcgct 120
gctattactc cccccgaaga acgccaccgg tccagcgcgt gggccgccgc ggtccccatc 180
acaaactgaa cccccaacag gggacatgct tagcggtagg gcgcgcgcca aggcggcagc 240
aatcgcatca ctgcgctgcg cgtcactatt aacccacccg gacttcactt ccacgacccc 300
gaatggcgcc cggtcattga tcatcttgcg caccgcggat aatccgggat tg 352




405


420


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






405
accggggcca ctccgcacaa tctgtacccg accaanatct acaccatcga atacgacggc 60
gtcgccgact ttccgcggta cccgctcaac tttgtgtcna ccctcaacgc cattgccggc 120
acctactacg tgcactccaa ctacttcatc ctgacgccgg aacaaattga cgcngcggtt 180
ccgctgacca atacggtcgg tcccacnatg acccantact acatcattcg cacgganaac 240
ctgccgctgc taaagccact gcgatcggtg ccgatcgtgg ggaacccact ggcgaacctg 300
gttcaaccaa acttgaaggt nattgttnac ctgggctacg gcganccggc ctntggttat 360
tccacctcnc cgcccaatgt ttgcnactcc cgttcggggt tgttcccnna aggtcaaccc 420




406


328


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






406
cgctcaagcg cntgaggccg aancggctgg ttacgactcc ctgtttgtga tggaccactt 60
ctaccaactg cccatgttgg ggacgcccga ccagccgatg ctggaggcct acacggccct 120
tggtgcgctg gccacggcga ccgagcggct gcaactgggc gcgttggtga ccggcaatac 180
ctaccgcagc ccgaccctgc tggcaaagat catcaccacg ctcgacgtgg ttagcgccgg 240
tcgagcgatc ctcggcattg gagccggttg gtttganctg gaacaccgcc agctcggctt 300
cgagttcggc actttcagtg accggttc 328




407


315


DNA


Mycobacterium tuberculosis



407
ctcaagcttg cgttcgatga agtagtcgtc ggtcagcgcc gcctcttcga gctccttggc 60
gatgcccagc aaggagtcat cgccgccgag cttggccagg atcttgtcgg cctgttcctt 120
gacgatgcgg gcccgcggat cgtagttctt gtagacacga tgaccgaaac ccatcaattt 180
gaccccggcc tcgcggttct tgaccttgcg tacaaactcg ctgacgtcgt cgccgctgtc 240
gcgaatgccc tcgagcatct ccaggacagc ctgattggcg ccgccatgaa gcggacccca 300
tagtgcgttg atgcc 315




408


329


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






408
ggtcaggccg agcaggcgcg aggaacgacg aacccaacaa gccatggtgg ttggcgccgt 60
cgagaggtcg gcggtcgcca caacgggaag atcgccttga gcgtcgctcg accgccgcct 120
cgagttgggt cataacgaag tagctgatgc cgatcatgtc gacgtttccg tcgcatcagc 180
gtgcagcggc gacccactcn acgaggtctc ggtgccgccg cggccagggc accagcagtg 240
acgagtccag gcgccgtcgg gccaagcagt cgcggtgcca nccgtggtgg gtcgggcgat 300
ggttgggtgt gctcatttcg ggaacgcca 329




409


294


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






409
ctcgaagctt taacagcatc aaccccgccc cgcaccagca ccgacacnat gtcgatgcca 60
tcgaggtgaa tgtcgaactg gcgcaaacca tcggcgaccg cgaccaccgg caacatgggt 120
accggcgatt tccggtgcca atgccgaccc gacgggccgc tctcaccgca ggtgacctcg 180
atcaccgaga ccanccggcc gttntnntca cgcaccccta ccgtgtcacg cccaaaacgg 240
cgctggtggt cgattgccgg agtgcacccc ncacccagtg tcgtgcccgg atcc 294




410


288


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






410
tgatgccgca cccgatcgac ggtcgttggt cggggttgac tggccgcccg gcgaagcagg 60
gcgtcgaccg cggcccggac gtcggcggcc gtcaccggtc ggccattgcc cgggcgggag 120
tcgtcgagct gaccacggta gacaagtcgg cgctggccgt cgaagacnaa cgtgtcgggt 180
gtgcaggccg cggagaaggc gcgggcgacn tcttgggttt cgtcgtanag atacgggaac 240
gtccagccgt ggcggcgggc ctcggcgacc atctgatcgg gcccgtcc 288




411


420


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






411
tttcgggcga ggcggtatan cttcccntcg taccggcgac cgccagccga naagctcgtt 60
ttcccagtgt tgctggggat tctcacgctg ctgctgantg cgtgccaaac cgcttccgct 120
tcgggttaca acgagccgcg gggctacnat cgtgcgacgc tgaagttggt gttctccatg 180
gacttgggga tgtgcctgaa ccggttcacc tacnactcca agctggcgcc gtctcgtccg 240
caggtcgttg cttgcgatag ccgggaggcc cggatccgca atgacggatt ccntgccanc 300
gctccgagtt gcntgcggat cgactacnaa ttgatcaccc anaaccatcg ggcgtnttac 360
tgcctgaagt acctggtgcg ggtcggatac tgctatccgg cggtgacaac cccggcaagc 420




412


378


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






412
gttttggctc ggcatggtta gccaaggttc tgcggtccca ccagatcatc ttggtccggt 60
agcgctcgtc cgggtatgct gccgccggga ttctcgctgc tattactccc cccgaagaac 120
gccaccggtc cagcgcgtgg gccgccgcgg tccccatcac aaactgaacc cccaacaggg 180
acatgcttag cggtagggcg cgcgccaagg cggcagcaat cgcatcactg cgctgcgcgt 240
cactattaac ccacccggac ttcacttcca cgaccccgaa tggcgcccgg tcattgatca 300
tcttgcgcac cgcggataat ccgggattgc cagcccattc nactaccgca tgcgagtcat 360
cggctgaccg cagcggtc 378




413


347


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






413
tcgcctaggc gggcttcccc ttccgtccga gcngtcagaa gctcctatga caatgcacta 60
cccgagacna tcaacggcct atgcaatacc nagctgatca aacccggcaa gccctggcgg 120
tccatcgagg atgtcgagtt ggccaccgcg cgctgggtcg actggttcaa ccatcgccgc 180
ctctaccggt actgcggcga catcccgccg gtctaactcg acgccgcctc actacgctca 240
acgccagaga ccanccgccg gctgacgtct cagatcagag agtctccgga ctcaccgggg 300
cggttcatcc ccactgtcga tagcgtctgt ggataacttt gtctgca 347




414


165


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






414
gcgcgtngaa ctgataggtg cggcccggct cgagcangcc ggccatttgt tcgatgcggt 60
taccgaagat ctcttcggtg acctgcccgc cgccggccag ctcggcccag tgcccggcgt 120
tggccgccgc ggcgacaatc ttggcgtcca cggtggtctg ggtca 165




415


317


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






415
ctcaagcttc aatacagagt tataaactgt gataatcaac cctcatcaat gatgacnaac 60
taacccccga tatcaggtca catgacgaag ggaaagagaa ggaaatcaac tgtgacaaac 120
tgccctcaaa tttggcttcc ttaaaaatta cagttcaaaa agtatgagaa aatccatgca 180
ggctgaagga aacagcaata actgtgacaa attaccctca gtaggtcaga acaaatgtga 240
cgaaccaccc tcaaatctgt gacagataac cctcagacta tcctgtcgtc atggaagtga 300
tatcgcggaa ggaaaat 317




416


379


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






416
ctcaagcttc gatcgacatt actcccgcct tgggtctggt ctccgagctg gtcggtcatg 60
gtcggacctg ctggtagtgg ggatctaacg caacatggtc gggattcatc atggtgtacc 120
cgtgataccc attcgcagct gccggtgaaa ccccgcgatg ccgggatttc cagccgcact 180
aggatgtcta gccggccagc cgctgccgcc ggacttcggg atgttcggta taccancgat 240
cggcaatctt gcgtatccgc cgatgctcga acgctancca cgccaaacca accactgtga 300
cnacaatcgc caccacacca aaggtcatgc cctcggcgtg atgtccggtg ccgaaagccg 360
caagagctcc gacgccgcc 379




417


420


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






417
cattcccaat tgaatttccc natcccacaa tctcggttca gatacaggtc gccatacccc 60
ttacttcggc aacgctgggc ggattggccc tgccgctgca gcanaccatc gacgccatcg 120
aattgccggc aatctcgttc agccaatcca tacccatcga cattccgccg atcgacatcc 180
cggcctccac tatcaacgga atttcgatgt cggaggtcgt gccgatcgat gtgtccgtcg 240
acattccggc ggtcaccatc accggcacca ggatcgaccc gattccgctg aacttcgacg 300
ttctcagcag cgccggaccc atcaacatct cgatcatcga cattccggcg ctgccgggct 360
ttggcaactc gaccgagctg ccgtcgtcgg gcttcttcaa caccggcggc ggtggcggct 420




418


255


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






418
ctcaagcttt cggcggagac ggacannttg cgaacattga tgacaaaata gaaatcattg 60
atggtttgag tcaccaggcc gatcaagcct tcgccgagcc aaattccaat caagaggccc 120
aagcccgtac caatcagccc ggcaacgagg gattccgtca ttatcagcca aaataactgc 180
tctcgggtta cacccaaaca gcgcaatatg gcgaaaaacg gtcgccgttg cacgacatta 240
aatgtcacgg tattg 255




419


359


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






419
agcttaactg ctccctaata cctggggctg tgcctgcggt gtatgcacgg catacggaca 60
tccntcccct gagacccncg gtctaatcag ccacgtgtcc accatcaggg gtcaaccccg 120
gccaagggcg acggcacccc aagttcgccg accgttaacc tattgctgtg agcttcattt 180
gctgcgagca aaacagttgg tcggccgtta ggaactgaat tgacactcaa ccgatttggt 240
gccnccgtag gtgtcctggc tgcgggtgcg ctggtgttgt ccgcgtgtgg taacgaccac 300
aatgtgaccg ggggaggtgc aaccactggc cacgcgtccg cgaatgtcta ttgcggggg 359




420


314


DNA


Mycobacterium tuberculosis



420
ctcaagcttg gggtggcgct gtcggtcggt gtgcttggcg gcgtcggtat caacaccgcc 60
cacgaaatgg ggcacaagaa ggattcgctg gagcggtggc tgtccaaaat caccctcgcc 120
cagacctgct acgggcactt ctacatcgag cacaaccgtg gccatcacgt ccgggtgtcc 180
acaccggagg acccggcgtc ggcgcggttc ggcgaaacgt tgtgggagtt cctgccccgc 240
agtgttatcg gcggcttgcg ctcggccgtt catttggagg cccaacggct gcgtcggctc 300
ggcgtcagcc ccct 314




421


280


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






421
gcaccaaggc cccacacgtc accctgtgac ctcctgcgcc gaccccgccc gaggtcctgg 60
ccgttaccac ctgaacgggc gagccgggag tctggtacgc atcgaacaaa gagcaaggtg 120
catgggcgga gttgttccgc cacttcgtcg atgacggggt cnatccattc gaggtccgtc 180
gccgcgtcgg tcgagtggcg gtcacactcc aggtactcga cctcacagac gagaggactc 240
gatcccatct aggtgtggac gaaacagatc ttctgtccga 280




422


230


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






422
tcgcctccgc atatgggtcg acgccaagcg ggtccggatt tctgggcttc atcgctcgcg 60
ccgtcgcgac aaacagcgcg gtcgaaccga cactcgttgt gatgtcccag ctatcacctt 120
cggtacgcac ccaatcgacc ctacncggct atctcagccg cgatctccag gctccgccga 180
gccaggtgca tcccggtccg gatcccacta acccggcacc attggcgtcn 230




423


272


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






423
gtcctcgagt gccgccgtcg ncacncccag cgcccgcgcg gccacttgga tgcgacccgt 60
ttcaagtccc ttcatcatct gcgaaaagcc ttgacccatg gctccgccca ggatcgccga 120
gaccggcacc cggaggttgt cgaacgacag ctcgcaggat tcgacgccct tgtaacccaa 180
cttcggcaag tcccgcgaca ccgtgagtcc cggcccgggt tcgacgagca cgatcgacat 240
gccttggtgc cgcggtgtgg cgttcgggtc gg 272




424


423


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






424
ggcataccaa tgtggacttc tgctcaccca cgatatccgt ggtctgatcc gctgctgcgg 60
cgggctgcna cctgcntctc ngcggcaccc gtnactacat ggcncgcgcc gcacgcatac 120
gtcgcggcgg gacccactcc nactggtcga cggtgctggc cgcgtgtccg cangtcccna 180
acccggccgc accgacgaaa ccggccgccg tccgttctgg accaacgctc atgtgccgtc 240
ggggtccatg ctcgacgcca tcgagaccgt aaccagcgtc ctcgagcggt tcgcctccgg 300
cttccgtgac atcttcgtgg ctgctcgcgc cgtgccgccg cgcggatggt cgaccacaac 360
gccaaccacc tcggcggtga catcaccgtc cgcgccactc gacctggcgc gcgatcgcgg 420
ccc 423




425


315


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






425
gtgagcagac ctacgccncc tggttgcgcc aactcggtac cgatcatggc gcgcngcctg 60
tcgtcaccga tacccagcga acaagacagc ccggtccgcg acaagatgac tttcccgatc 120
tcttcggcga cttccatggg gtcgtccgga gtcccgggcg ccaccgcgag gtaaccctcg 180
tctcagtccc atacgcgacc gggtatccac gtcgcgcaac aacgccacca cctccccaga 240
cgccncgttg tacgcggctg ggttccacng caataagtgg cctcanggca tcgtccggcg 300
gcggtccnca acgca 315




426


335


DNA


Mycobacterium tuberculosis



426
ctcaagcttg aggttaactt tgaacggatc gagctggacg ttcgagacgg tgatcgggcc 60
gaacctgaat tgtccggtaa tgcccaacgc aaaaagcagg gtggtggccg gggcggtgaa 120
accggcgtcg gcggcaccgt cgaaatctat gtggattgcc ggaatgggga tgtccggcac 180
ggcgaaaccg tagttcgctt gtcccgtgag gcccaggtgg atggggggaa agatcctggt 240
gtccgggata ataatggggc cgatgccgcc ggttgaagtc cactggatcg ggaattccgg 300
aatcttgatc cgacgttcag gccgaacagg ccctc 335




427


346


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






427
cggcgacgtc gcgatacgcc gagcagttgg gaatcgctct gcagcaaacc aatattctgc 60
gcgacgttcg agaggacttt ttgaatggac ggatctacct gccgcgcgac gagctggacc 120
gattaggcgt acgcctccgc ctggacgaca ccggggcact cgatgacccc gacggacggc 180
tcgcggcnct gctgcggttc agtgccgacc gcgccgcaga ctggtnttcg ctgggactgc 240
ggctgattcc acacctcgac cgccgcagcg ctgcctgctg tgcggccatg tctggcatct 300
accgccgtca gctcgccttg atcagagcat cgccggcggt cgtcta 346




428


332


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






428
ctataaaata ctcaagcttg atgccgccga aaccgagcgt gagcacgccg ccagccacca 60
cgcgcgggtc gggcgccggg cccgggccgc caggctgctc cgctcggtga tggcacgcca 120
ccgcgacacc acccggntgc gctacgtcna gccataccgg gcggagctac atcggctcgg 180
ccgcccagtg ttcgggccct ctttcgaggt cnaggtcnat accgatttgc gcatccgcag 240
ccgcaccctg aacnacanaa ccgtgcccta ctattgcttg tcnggcgggg ccaaaaaaca 300
gcttggcatc ctggcccnat tggccggcgc gg 332




429


276


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






429
cttcggtcgc agtgtgcgag tgatagatga cgaccgggac ctcgtcggca tcttccatag 60
cccgccacac cttcagttgc tcaccggaat ccaaccggta gaaggtcggc gagcgctcgg 120
cattggtcat cgggatatgc cgctcgggac ggtcagagcc ctcgggtccg gccagcactc 180
cgcaggcttc gtcggggtgg tcgcgacgcg catgggccac catcgcattc accaggtctg 240
cgcgaatcnc cancacgtan acngttcctt tcctaa 276




430


420


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






430
ctggcaccaa ggccccacac gtcaccctgt gacctcctgc gccgaccccg cccgaggtcc 60
tggccgttac caccgaacgg gcgagccggg agtctggtnc gcatcgaaca aanagcaagg 120
tgcatgggcg gagttgttcc gccacttcgt cgatgacggg gtcnatccat tcgaggtccg 180
tcgccgcgtc ggtcnagtgg cggtcacact ccaggtactc gacctcacag acnaaaggac 240
tcnatcccat ctaggtgtgg acnaaacaga tcttctgtcc gacnactaca ccaccaccca 300
ggccatcgcc gccgcccgcg atgccaactt cgacgccgta ctggccccgg cggggggcgc 360
tccccggttg tcaacacttg ccgtgttcnt tcacgcnctg ccccacatcc aaccccaacg 420




431


130


DNA


Mycobacterium tuberculosis



431
gttcttgggc ccatgcggag gtatcgccgt ttccaccacg cggtcggggt ggcgttgcat 60
tagctcaccg atggtgcgct tgtgcaggcc gccgggatac cccgagtgcc ggtaaaccat 120
cttgtgctgc 130




432


215


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






432
caatactcaa gcttggcgtg ccgttccaac ccgaattggc tttcggcgcc atcggtgagg 60
acggcgtgcg ggtgctcaac nacnacgtcg tccgcgggac acacctcgat gctgccgcca 120
tggacgcggt cgaacgcaag cagctgatcg agctacaacg ccgcgcggaa cgcttccgcc 180
gcgggcgtga ccgcatcccg ttgaccgggc ggatc 215




433


360


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






433
cntcatgatg atcatcaccc gaagtgtggt agccgcagtg gttatcgtgg gtaccgtcgt 60
gctttccatg ggcgcctctt tcgggctttc cgtattggtc tggcaggaca ttctgggtat 120
cgagttgtac tggatggtgt tggcgatgtc ggtgatcctg ctcctggcgg tgggatccga 180
ctacaatctg ctgctgattt cccggttgaa agaggaaatt ggggccggat tgaacaccgg 240
aattatccgt gccatggctg gtaccggggg agtggtgacg gctgccggca tggtgttcgc 300
cgttaccatg tcgttgtttg tgttcagcga tttgcgaatt attggtcaga tcggtaccac 360




434


265


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






434
atactcaagc ttttacggtg atcgcncatc acctggttca tgaactggaa gcagcgcagc 60
gcttcctttt cggccgcaac atgagccagc ctctcgtcgg cggtcgggtg caggtgctcg 120
ggcagctcgg ccgcnacagc cgcctgaccc tgaaaccagc ttccatatcc cgcgannaac 180
gacgccagtc cgctacgtna cccctccgcg actgtccatg gacaacagcg cgttctccac 240
cgaccgggcc cgggtgtggg gtntt 265




435


264


DNA


Mycobacterium tuberculosis



435
gctggtagag tcgctgaccg gtgcaggttt cgacaatgtg gtgccggttc ggcggctacg 60
tgccatcgag acactggcgc aggctatcgc acccgttatc ggctacgagc aaatcgcggt 120
atgcgttctt gagcatgagt cggcgaccgt cgtcatggtc gacacccacg acggaaagac 180
gcagatcgcc gtcaagcatg tgtgccgcgg attatcagga ctgacctcct ggctgaccgg 240
catgtttggt cgcgatgcct ggcg 264




436


335


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






436
gctttccgcc gatacccgcc atgtcncgca catccaggac ttctgggggg atccgctgac 60
agcggcggga tcccaaagtg cggatgatcg ggccgcctac gtcgtggtgt acctcgtcgg 120
taacaacgaa accgaagcgt atgactcggt ccacgcggtg cggcacatgg tggacaccac 180
accgccaccg cacggggtga aggcctatgt caccggtccg gcancactca atgccgacca 240
ggccgaggcc gganacaaaa ntatcgctaa ggtcaccgcg atcacnagca tggtgatcgc 300
agcaatgttg ctagtgatct atcgctccgt aatta 335




437


304


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






437
cttccaaccc gaattggctt tcggcgccat cggtgaggac ggcgtgcggg tgctcaacga 60
cgacgtcgtc cgcgggacac acctcgatgc tgccgccatg gacgcggtcg aacgcaagca 120
gctgatcgag ctacaacgcc gcgcggaacg cttccgccgc gggcgtgacc gcatcccgtt 180
gaccgggcgg atcgcggtga tcgtcgatga cggcatcgcc accggagcga cggccaaggc 240
ggcgtgccan gtcgcccggg cgcacggtgc ggacaaggtg gtgctggcgg tcccgatcgg 300
ccca 304




438


223


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






438
tactcaagct tcgcgagatc cggatggcac tcacgctgga caagaccttc acaaaatctg 60
aaatcctgac ccgatacttg aacctggtct cgttcggcaa taactcgttc ggcgtgcagg 120
acgcggcgca aacgtncttc ggcatcaacg cgtccganct gaattggcag caagcggcgc 180
tgctggccgg catggtgcaa tcnaccagca cgctcaaccc gta 223




439


263


DNA


Mycobacterium tuberculosis



439
cccacgactt tctcctcgat cagttggatt tgtacgaaga ggcaacgaaa gcagtgatcc 60
tcgggatggt cgacgcctac atcgacccgc cgttcacgcc gcacagcctg ctagatgcgc 120
tgggcgagca ggtcccacag ttcgccgcta aggcacggcg tctgttcccg tccggatcgc 180
cattcggcct cggcgtcctg ctcccattcg atcaataggg ctggcagctc cgtcggcagg 240
ggcctacgcc tcaccccgtc acg 263




440


301


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






440
ctcaagctta tgcgcgccgg ccgaggtctg ctcacggcaa cccctgaagt ttaggggacn 60
acctactcag cgcaaaattt cgctaatgtg agtccgcccc accaggggna natcaaccca 120
tgtcgatcat gatctacccg gataccggat tggcggtagc gcccacgatc gtcnaaatnt 180
ccgcctgaat catcggatag ctgatccggc gtcaacgcgt tttganttca ccgcgcaaca 240
gccgccaggc cggcccgcan cganccgatc tcntcgggcc gcatgggccc caatcttntc 300
g 301




441


90


DNA


Mycobacterium tuberculosis



441
gtgtgtggtg gaacccatct gagcagtgtg ccaaaccggg gcagacagct cccaattgac 60
gtgagcccgc tcacttgctg ggtaagcgtc 90




442


183


DNA


Mycobacterium tuberculosis



442
ctttacactt cctgcatccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc 60
acacaggaaa cagctatgac catgattacg ccaagctatt taggtgacac tatagaatac 120
tcaagcttgg gcgtgacggc caccggggcc actccgcacc atctgtaccc gaccaagatc 180
tac 183




443


348


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






443
caggcatgca agctttagct gcccgaatgc gtcaccccga tgcgcccaga tcggggcttc 60
gcagataaag cacgaacagg cgggcaaaac gtcnatctcg gagccggaag ggcaatcagc 120
cgaccgtcga cgaacgacac cggcgagacc acttaggcag tgacggccgg cccgaacatt 180
acgcgctcgt tgattaggcg ttcggtctcg tccgcggtca tgccgagcag cttgcggcag 240
atctgaacgc tgtcctgtcc gggcagcggc gccgggcgtt ggggtgcctg cccgaatgtg 300
acgaaacgga gccggacccg tctcggcggg ccgcggacgg cgatccgc 348




444


335


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






444
cncaagcttg cggatgttac ccctgacagc ctgaactatg tcnaaacaca cggcaccgga 60
acggtgttgg gggaccccat cganttcgag tcgctggcgg ccacttatgg cctgggtaaa 120
ggccagggcn anagcccgtg cgcattgggg tcggtcaaaa ccaacatcgg ccacctggag 180
gcggccgccg gtgtggctgg atncatcaag gcggtgctgg cggtgcaacg tgggcacatt 240
ccccgcaact tgcacttcac ccggtggaac ccggccatcn acgcgtcggc nacgcggctg 300
ttcgtgccna ccnaaaaccc cccgtggccg gcggc 335




445


289


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






445
ggaaccggta accagatcag ctcgtcgacc tcactgccgg gggtgaattc cccaccggtg 60
ctgcgcgctg cccagtagtg caccttcttg acgcctcgaa aaggggagtc ggtcgggtag 120
gtcaccgtca ggagccgcct acccaggttg gcgcnatagc cggtctcctc gagtatctcc 180
cgcaccgccc ccaccggtgc ggtctcaccc anatccactt tgcccttggg cagcgaccag 240
tcgtcgtanc nggggcggtg aatgacaacg atctcgaccg gcccttccn 289




446


263


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






446
tactcaagct tcagaacagg cctgttgtgg gcncacccgg ctcgccgagt tctgcacgca 60
ccgcctcaag tgcggcccgc accgccggca tctcccggtc acgcagggcc gcggcccgcg 120
ccgcagcgac ggcgtgttcg cgcagttcgc cgtcaatgat gctgacctga tcggccaccc 180
gggcgttctc ggcgtcgtcg cgttcactaa tcgcggtgct cagcagcgtc tcgacagcca 240
ccacccgagt ggcgaccagc tgc 263




447


279


DNA


Mycobacterium tuberculosis



447
taatgtcttg ccaacgtcac cacaatcgcg atgaattcaa tcatgccgcc cagggcggcc 60
aacccaatgg tggccgcgag cggcagctcg atcgcagcgc ggaggttgcc ggccgccagt 120
tgattcacga acagggtgag gtcataggcg ggcaggatag tgacgaaggc aagacctata 180
tctgccgtcg gaagaagaat cgagtagccg gtcgacacaa cggaagcgaa agtgtccgcg 240
atgttgatga gcgtcgccgg ttgtggcggc ggtggcggc 279




448


295


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






448
tactcaagct ttcgtcagtt catcgcgcca gcagaccaac aagagcatcg ggacatacgg 60
agtcaactac ccggccaacg gtgatttctt ggccgccgct gacggcgcga acgacgccag 120
cgaccacatt cagcanatgg ccagcgcgtg ccgggccacg aggttggtgc tcggcggcta 180
ctcccagggt gcggccgtga tcgacatcgt caccgccgca ccactgcccg gcctcgggtt 240
cacgcagccg ttgccgcccg cagcgganna tcacatcgcc gcgatcgccc tgttc 295




449


280


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






449
ccacccgtgt aatttgggat gggcnaaaag gcnaagcacc gcgtggccac gaacgccggg 60
agggacaatc tcgggcggct agggcttctc gcgggaaggc ccgaacgtac ggcgtttcaa 120
cacgtcgcgt cgccctccga ccgcgaacat tcggggatgg cagcaacctg gtagcaccct 180
ggccgggcga tgatctgcag cgtcgccgcg ggtagtcgcc gcccgggcgg ctacagtctg 240
aaacgcgatg accatcgatg tgtggatgca gcatccgacg 280




450


320


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






450
tcaagcttta gctgcccgaa tccgtcancc cgatgcnccc agatcggggc ttcgcanata 60
aagcacnaac aggcgggcaa aacgtcnatc tcggagccgg aagggcaatc anccgaccgt 120
cnacaaacga caccggcgan accacttagg cagtgacggc cggcccgaac attacncgct 180
cgttgattag gcgttcggtc tcgtccgcgg tcatgccgag cagcttgcgg canatctgaa 240
cgctgtcctg tccgggcagc ggcgccgggc gttggggtgc ctgcggaatg tgacnaaacg 300
gagccggacc cntctcggcg 320




451


203


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






451
ccggggccac tccgcacaat cngtaccnna ccaanatcta caccatcgaa tacgacggcg 60
tcgccgantt tccgcggtac ccgctcaact ttgtgtcgac cctcaacgcc attgccggca 120
cctactacgt gcactccaac tacttcatcc tgacgccgga acaaatngac gcntcggttc 180
cgctgaccaa tacggtcggt ccc 203




452


287


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






452
nctggccttt ggtccacact aanacaatac tcaagcttcc ggccgcagag ccgccaactc 60
acgatatcgt taaccgatat cccgagccga tagctggcgg gctcgggtgg tggccagcgg 120
cgctgcgacn aaaggtgtga ccgtcatgaa acagacacca ccggcggccg tcggccgtcg 180
tcacctgctc ganatctcag catccgcagc cggtgtgatc gcgctttcgg cgtgtngtgg 240
gtcnccgccc gagcccggca aaggccggcc cgacacaacc ccggaac 287




453


272


DNA


Mycobacterium tuberculosis



453
catctgccca ccacacggac cgcggtgcgg acgcggctga cgcgcctggt ggtcagcatc 60
gtggccggtc tgctgttgta tgccagcttc ccgccgcgca actgctggtg ggcggcggtg 120
gttgcgctcg cattgctggc ctgggtgctg acccaccgcg cgacgacacc ggtgggtggg 180
ctgggctacg gcctgctatt cggcctggtg ttctacgtct cgttgttgcc gtggatcggc 240
gagctggtgg gccccgggcc ctggttggca ct 272




454


364


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






454
gacaatactc aagcttgact ggccacccac cggcatgacc accgacaggc ccgactggtc 60
gtaccactcg aacgccgggg tgttgatgtc ccagccgctg aantcgtcct gcgcgcgcag 120
gccgtcnaac aggtacaggg cgggcgaatt ggcaccacca ctttggaatt ggaccttgat 180
gtcacggccc atcgacggcg acggcacctg caggtactcc accggcaagc ccggccggga 240
aaatgccccc gcggtcnccg tgccaccgac ggcgccganc aaacccgaca ctagggccgc 300
gccnacggcc ccgaccacna ntcnacgcga catacccgtg acggcgccac naaccctgtc 360
aaca 364




455


360


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






455
cctccaactc ggcggggaag cgacnccagc ctaccgagct tggagtccan gacgccagcg 60
gcggcgtcgg tctgcgtcgt ggtgccgccg gggtggcgtt ggctggcaac gatctccacc 120
cagccggtcg ggttacccac gatctcggca tanacgcggg ccgaggccgg tgcgataccg 180
tattgcgtca attgggacgc ggttgtgcat tcggctagct cggttgccac acccgtcagg 240
ggttcgacgt tggcgggttc ggcgggcccc ancaccgctg tcaccatgcc cgccaagccg 300
acctgcggcg ccaccaactg cagcaccanc atgtcgccgt cgcgcgccgc gatcacatgg 360




456


311


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






456
ctcaagcttt ttgagcgtcg cgcggggcan cttcgccggc aattctacta ncgagaantc 60
tggcccgata cggatctgac cgaantcgct gcggtgcanc ccaccctcat tggcgatggc 120
gccgacnatg gcgcctggac cgatcttgtg ccgcttgccg acggcgacgc ggtaggtggt 180
caagtccggt ctacgcttgg gcctttgcgg acggtcccga cgctggtcgc ggttgcgccg 240
cnaaagcggc gggtcgggtg ccatcaggaa tgcctcnccg ccgcggcact gcacggccag 300
tgccgcggcg a 311




457


288


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






457
cnccagcttg attggtctgg ttgcattggc cagctgcgcg agcctggctc acttcaacta 60
cgacgaccgc aaacaattgc cgccttcgga tccgagttcg gttgggtacg cggcaatgga 120
gcaccatttc tcggtgaatc agactattcc tgagtacttg atcatccact ctgcacacga 180
cctgcgaacc ccgcgcggcc ttgccgacct ggagcagctg gcgcaacgtg tgagccagat 240
cccaggcgtt gccatggttc gcggtgtgac ccggccaaac ggggaaac 288




458


256


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






458
caatactcaa gcttgactgg gcccgcacct tcggcgccac ccacaccgtc aacgcccgcg 60
aagtcnacgt cgtccaggcc atcggcggcc tcacggatgg attcggcgcg gacgtggtga 120
tcgacgccgt cggccgaccg gaaacctacc agcaggcctt ctacgcccgc gatctcgccg 180
gaaccgttgt gctggtgggt gttccnacgc ccgacatgcg cctggacatg ccgctggtcn 240
acttcttctc tcacgg 256




459


327


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






459
tcgacggttt ggcggcctta aatgcactga ggtcgtcaat tgaccccaca gcggaaatgc 60
cgactattcg caggcctcct tcgccttggc tgccggagag gggctccgcg ggaaccgcat 120
gcaggtatat gacctcggtt tctcgggtgc taccgcgtgc cttgtntang atnanctcgg 180
cgttggaatt gtccagccgg cccaattcat cgagcgcana ttcgtacacn tggccggcgg 240
cgacatacgc ttcaccgtgg atctgctcca cacggaccgc cctgtcggga tcctgctcac 300
gggtaangga acttacgtgg cactcgg 327




460


100


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






460
gaccacgcca ggctaatcac gtgacgctac cgaataccct ncctagtggt gcaggctccc 60
gctggaaatg gccctgtacc aactcgcgca ccggtgccag 100




461


114


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






461
cggcacccga cccctttgag ccgtccgccg tggccgcggt ggaactggcc gacgagggac 60
tgatcgtgct gggcaaattg gtcgatggca cgctggccgc cgatctgaag gtcn 114




462


287


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






462
ctcaagcttg ccgttacccc gacttccgga gggacaccat gagcaccgcc agccgagcac 60
gaggccaaac tccgccgacg caggccggtt ggacttgtcg tgctggacaa ggggtttagc 120
cgccgaagca gtgacgtaca tcggcgaaaa gcagttcgcc tgtcgaccga cggngcnnac 180
cgtgaggcta gggaagcgag gagcacatgg ccgccgaccc gcaatgtaca cgctgcaagc 240
aaaccatcga acccggatgg ctatncntca ccgcccatcg ccgcggt 287




463


288


DNA


Mycobacterium tuberculosis



463
catgtcgcgc acatccagga cttctggggg gatccgctga cagcggcggg atcccaaagt 60
gcggatgatc gggccgccta cgtcgtggtg tacctcgtcg gtaacaacga aaccgaagcg 120
tatgactcgg tccacgcggt gcggcacatg gtggacacca caccgccacc gcacggggtg 180
aaggcctatg tcaccggtcc ggcagcactc aatgccgacc aggccgaggc cggagacaaa 240
agtatcgcta aggtcaccgc gatcacgagc atggtgatcg cagcaatg 288




464


255


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






464
atactcaagc ttcggtacgg tggcgggccg tgctgctggc cgcggtcgcg gcgtgcgcgg 60
cctgcggtct cgtttacnag ctcgcgctgc tgacactggc ggcnagcctg aacggcggcg 120
ggatcgtggc cacctccctg atcgtcgcgg gctacatagc cgcgctggga gcaggcgcct 180
tgctgatcaa gccgctactt gcacacgcgg ccatcgcgtt catcgccgtg gaggcggtgc 240
tgggcatcat cggcg 255




465


288


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






465
tgtcaagtcc tttcagatct cntttttatg acatgactgg agatctgtct agattgcagc 60
tcctgtgagc gtgggtaccg gattcaagcc ggtcggtcac gccgcggtgg taccggcttt 120
gcggcagtgc tcggcctcga gttcggcgat cgcgcgcgaa gtgcgttcgc gcagcaagat 180
cgcggccgta atgccggcga tgaccgcgat gaccagcgcg atccaggaga accgttccaa 240
ccagtgctgg gcggccatcc cggcgaagta gaccagtgca gtggtgcc 288




466


224


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






466
caatactcaa gcttcaaaac aggcctgttg tgggcgcacc cggctcgccg agttctgcac 60
gcaccgcctc aantgcggcc cgcaccgccg gcatctcccg gtcacgcagg gccgcggccc 120
gcgccgcanc gacggngtgt tcgcgcagtt cgccgtcaat gatgctgacc tgatcggcca 180
cccgggcgtt ctcggcgtcg tcncgttcac taatcgcggt gctc 224




467


320


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






467
tacgctggcg ctggagggag ccanntacaa catccacgcc aatgctcttg ccccgatcgc 60
ggcgaccagg atgacccagg acatcctgcc gcccgaagta ctggaaaagc tcacacccga 120
gttcgtcgca ccggtggtgg cctacctgtg caccgaggag tgtgccgaca acgcatcggt 180
gtacgtcgtc ggtggtggca aggtgcagcg agttgcgctg tttggcaacg acggcgccaa 240
cttcgacaaa ccgccgtcgg tacaagatgt tgcggcgcgg tgggccgaga tcaccgatct 300
gtccggtgcg aaaattgctg 320




468


303


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






468
gcttttcccg tccgtcnncg ctcaaccgcg tgaggccgaa gcggntggtt acgactccct 60
gtttgtgatg gaccacttct accaactgcc catgttgggg acncccgacc agccgatgct 120
ggaggcctac acggcccttg gtgcgctggc cacggcgacc gancggctgc nnntgggcgc 180
gttggtgacc ggcaatacct accgcagccc gaccctgctg gcaaanatca tcaccacgct 240
cgacgtggtt agcgccggtc gagcgatcct cggcattgga gccggttggt ttganctgga 300
aca 303




469


391


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






469
cngcttttta atggccttga cntgggcgng ccggccaccg gggccactcc gcacaatctg 60
tacccgacca agatctacac catcgaatac gacggcgtcg ccgactttcc gcggtacccg 120
ctcaactttg tgtcgaccct caacgccatt gccggcacct actacgtgca ctccaactac 180
ttcatcctga cgccggaaca aattgacgca gcggttccgc tgaccaatac ggtcggtccc 240
acgatgaccc agtactacat cattcgcacg gagaacctgc cgctgctaga gccactgcga 300
tcggtgccga tcgtggggaa cccactggcg aacctggttc aaccaaactt gaaggtgatt 360
gttaacctgg gctacggcga cccggcctat g 391




470


343


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






470
ctcaagcttg ccgggagggt gcatggccga ctcggattta cccaccangg ggcgccaacg 60
cggtgtccgc gccgtcnagc tgaacgttgc tgcccgcctg gagaacctgg cgctgctgcg 120
caccctggtc ggcgccatcg gcaccttcga ggacctggat ttcgacgccg tggccgacct 180
gaggttggcg gtggacgagg tgtgcacccg gttgattcgc tcggccttgc cggatgccac 240
cctgcgcctg gtggtcgatc cgcgaaaana cgaanttgtg gtggaggctt ctgctgcctg 300
cgacacccac nacgtggtgg caccgggcag ctttagctgg cat 343




471


303


DNA


Mycobacterium tuberculosis



471
ccgacgccgt cgtggccacc aacaccgcga ccagcaccgt gacccggacc ggggtgccgc 60
gcgaaccggt cttggccaat tgccgcggca ccaagccgtc gcgcgccatg gcgaacagca 120
cgcggcattg cccgagcatc aacaccatca ccaccgtggt aagcccggcc agcgcgccga 180
cggagatgat gccgctggcc cagtacaccc cgttggcctg gaacgcggtg gccagatttg 240
ccggcccgcg gcccggtacg gtccgcagtt gggtgtatgg aaccatgccc gacagcacca 300
ccg 303




472


264


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






472
ttnactggcc tttggtccac actagacaat actcaagctt ccaggacatc gtcatcgcga 60
ccaaaaccgc gagctaggtc ggcatccggg aagcatcgcg acaccgtggc gccgagcgcc 120
gctgccggca ggccgattag gcgggcaaat tagcccgccg cggctcccgg ctccgantac 180
ggcgccccga atggcgtcac cggctggtaa ccacgcttgc gcgcctgggc ggcggcctgc 240
cggatcaggt ggtaaatgcc gaca 264




473


280


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






473
ngacgtcttc catccgcgcg tcgttttggc gggttggcca cagcagcccg ccggtgacgg 60
cgacgatgct gggctggttg cggccctgcg ccaccgcggc ttgcatgctg gttggctgtc 120
ttgggacgat cccgaaatag tccacgcgga tctggtgatt ttgcgggcta cccgcgatta 180
ccccgcgcgg ctcgacgagt ttttggcctg gactacccgc gtggccaatc tgctgaactc 240
gcggccggtg gtggcctgga atgtcgagcg ccgttaccta 280




474


153


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






474
cttcctcctg agtaccnccc gtntactttg ggatgggtaa aaaggcgaat cnccgtttgg 60
tcacgaacgc cgggagggac aatctcgggc ggctggggcc tctcgcggga angcccgaat 120
gtacggtgtc tcgacacttc ccntccccct ccg 153




475


247


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






475
gagcatcggg acntacggag tcaactaccc ggccaacggt gatttcttgg ccgccgctga 60
cggcgcgaac gacgccngcg accacattca gcagatggcc agcgcgtgcc gggccacgag 120
gttggtgctc ggcggctact cccagggtgc ggccntgatc nacatcgtca ccgccgcacc 180
actgcccggc ctcgggttca cgcagccgtt gccgcccnca gcggacgatc acntcgccgc 240
gatcgcc 247




476


264


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






476
tactcatgan catcctttaa tcanngcttt gcgttttttt attaaatctt gcaatttact 60
gcaaagcaac aacaaaatcg caaagtcatc aaaaaaccgc aaagttgttt aaaataagag 120
cancactaca aaaggagata agaagagcac atacctcagt cacttattat cactagcgct 180
cgccgcagcc gtgtaaccga gcatagcgag cgaactggcg aggaagcaaa gaagaactgt 240
tctgtcagat agctcttacg cnca 264




477


264


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






477
ctcaagcttc aggtcaatgt gcnccaagcc ctgacgctgg ccgaccaggc caccgccgcc 60
gganacnctg ccaaggccac cgaatacaac aacgccgccg aggcgttcgc ancccagctg 120
gtgaccgccg agcanancgt caaaaacctc aagacgctgc atgaccaggc gcttancncc 180
gcanctcagg ccaagaaggc cgtcnaacga aatgcgatgg tgctgcacca naagatcgcc 240
gagcgaacca agctgctcag ccng 264




478


352


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






478
catggtggca ctgtagcgac gtgctgcaat caaggtcatg cccgactctg gtcagctcgg 60
anccgctgac accccgctaa ggctgctcag ctcggtgcat tacctcaccg acggcgaact 120
cccccagctt tacgactatc cggatgacgg cacctggttg cgggcgaact tcatcatcag 180
cttggacggc ggcgctaccg tcgatggcac cagcggggcg atggccgggc ccggcgaccg 240
attcgtcttc aacctgttgc gtgaacttgc cgacgtcatc gtggtcggcg tgggcaccgt 300
gcgcattgag ggctactccg gcgtccggat gggtgtcgtc cagcgccagc ac 352




479


207


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






479
tactcaagct tgcgggtgat cgccttggtc aacggcaccg tgatcggatc ggggtcnacc 60
gcacaaatgg actggagctt cggcgaantc atcgcctatg cctcgcgggg ggtgacgctg 120
accccgggtg acntgttcgg ctcgggcacg gtgcccacct gcacgctcgt ctatcacctc 180
nggccaccgg aatcattccc gggctgg 207




480


256


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






480
gttggngcct cgtcggcgaa cagttctcgc acgatttccg gattagcggg actggtcacc 60
agttgggtat gcgggaaggc gctgacgttc gccgcgatta gctgtttgat ggacgcggtg 120
gtgatgttct gatcacggaa ctggctgtaa tagcccaggg tcgccacgct ttcatccggg 180
cccggacccg gcgcaccgag cgtgtcgcgc aggtatgcga cgtgattttc gctgaagtcc 240
ccgtacccgg agaact 256




481


397


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






481
tgcttccggc tcgtatgttg tgtggaattg tgancggata acaatttcac acaggaaaca 60
gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc aagctccagg 120
tcaatgtgcg ccaagccctg acgctggccg accaggccac cgccgccgga gacgctgcct 180
ttgtcaccga atacaacaac gccgccgagg cgttcgcagc ccagctggtg accgccgagc 240
agagcgtcga agacctcaag acgctgcatg accaggcgct tagcgccgca gctcaggcca 300
agaatgccgt cgaacgaaat gcgatggtgc tgcggcataa gatcgccgag cgaaccaagc 360
tgctcagcca gctcgagcag gcgaagatgc acgagca 397




482


379


DNA


Mycobacterium tuberculosis



482
caggcatgca agcttcggag gcagacccgt gcatggtggc actgtagcga cgtgctgcaa 60
tcaaggtcat gcccgactct ggtcagctcg gagccgctga caccccgcta aggctgctca 120
gctcggtgca ttacctcacc gacggcgaac tcccccagct ttacgactat ccggatgacg 180
gcacctggtt gcgggcgaac ttcatcagca gcttggacgg cggcgctacc gtcgatggca 240
ccagcggggc gatggccggg cccggcgacc gattcgtctt caacctgttg cgtgaacttg 300
ccgacgtcat cgtggtcggc gtgggcaccg tgcgcattga aggctactcc ggcgtccgga 360
tgggtgtcgt ccatcgcca 379




483


264


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






483
tactcaagct tggggtggcg ctgtcggtcg gtgtgcttgg cggcgtcggt atcaacaccg 60
cccacgaaat ggggcacaag aaggattcgc tggagcggtg gctgtccaaa atcaccctcg 120
cccanacctg ctacgggcac ttctacatcg agcacaaccg tggccatcac gtccgggtgt 180
ccacaccgga ggacccggcg tcggcgcggt tcggcnaaac gttgtgggan ttcctgcccc 240
gcantgttat cggcggcttg cgct 264




484


351


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






484
ggccatcgcc accgcnccgc ggcgaacgct caaaggcacc tactggcacc aaggccccac 60
acgtcaccct gtgacctcct gcgccgaccc cgcccgaggt cctggccgtt accaccgaac 120
gggcgagccg ggagtctggt acgcatcgaa caaagagcaa ggtgcatggg cggagttgtt 180
ccgccacttc gtcgatgacg gggtcgatcc attcgaggtc cgtcgccgcg tcggtcgagt 240
ggcggtcaca ctccangtac tcgacctcac agacgagagg actcgatccc atctaggtgt 300
ggacgaaaca gatcttctgt ccgacgacta caccaccacc caggccatcg c 351




485


328


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






485
gcttgcgggt gatcgccttg gtcaacggca ccgtgatcgg atcggggtcn accgcncaga 60
tggactggan cttcggcgaa ntcntcgcct atgcctcgcg gggggtgacc ctgaccccgg 120
gtgacntgtt cggctcgggc acggtgccca cctgcacgct cgtcaagcac ctcnggccac 180
cggaatcatt cccgggctgg ctgcacnacg gcgacntggt cnccctccag gtcgaagggc 240
tgggcnaaac aangcagacc gtccggacaa ncggcactcc ttttccgttg gctcttcggc 300
cgaatccgga cgccnaaccc gaccggcg 328




486


344


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






486
gttctcgcac gatttccgga ttagcgggac tggtcaccag ttgggtatgc gggaaggcgc 60
tgacgttcgc cgcgattagc tgtttgatgg acgcggtggt gatgtnctga tcacggaact 120
ggctgtaata ncccagggtc gccncgcttt catccgggcc cggacccggc gcaccgagcg 180
tgtcgcgcag gtatgcgacg tgattttcgc tgaagtcccc gtacccggag aactcgaaca 240
cgctgaggcg ctcgtcaccg tcgtnncggc gaccaagcgc ggcgagcaac tgcgcaaaat 300
cgttaagana ggtcgaatcg ttgaaattcg gcaccacctg cacc 344




487


285


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






487
cacaagacaa tactcaagct tcaggtcaat gtgcnccaag ccctgacgct ggccgaccag 60
gccaccgccg ccgganacgc tgccaaggcc accgaataca acaacgccgc cgaggcgttc 120
gcagcccagc tggtgaccgc cgagcananc gtcnaaaacc tcaagacgct gcatgaccag 180
gcgcttancg ccncagctca ggccaagaag gccgtcgaac gaaatgcgat ggtgctgcag 240
canaanatcg ccgancgaac caagctgctc agccagctcg agcag 285




488


280


DNA


Mycobacterium tuberculosis



488
ccacccgtgc atggtggcac tgtagcgacg tgctgcaatc aaggtcatgc ccgactctgg 60
tcagctcgga gccgctgaca ccccgctaag gctgctcagc tcggtgcatt acctcaccga 120
cggcgaactc ccccagcttt acgactatcc ggatgacggc acctggttgc gggcgaactt 180
catcagcagc ttggacggcg gcgctaccgt cgatggcacc agcggggcga tggccgggcc 240
cggcgaccga ttcgtcttca acctgttgcg tgaacttgcc 280




489


160


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






489
gctttccgcc gatacccncc atgtcccgca catccaggac ttctgggggg atccgctgac 60
agcggcggga tcccaaagtg cggatgatcg ggccgcctac gtcgtggtgt acctcgncgg 120
taacaacgaa accgaancgt atgactcngt ccacgcggtg 160




490


176


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






490
caacccgant tggctttcgg cgccntcggt gaggacggcg tgcgggtgct caacgacgac 60
gtcgtccgcg ggacacacct cgatgctgcc gccatggacg cggtcgaacg caagcagctg 120
atcgatctac nacgccgngn ggaacgcttc ngccgcgggc gtgaccgcnt cccgtt 176




491


216


DNA


Mycobacterium tuberculosis



491
gggatgggca aaaaggcgaa gcaccgcgtg gccacgaacg ccgggaggga caatctcggg 60
cggctagggc ttctcgcggg aaggcccgaa cgtacggcgt ttcaacacgt cgcgtcgccc 120
tccgaccgcg aacattcggg gatggcagca acctggtagc accctggccg ggcgatgatc 180
tgccagcgtc cccgcgggta gtcgccgccc gggcgg 216




492


163


DNA


Mycobacterium tuberculosis



492
cagcagacca acaagagcat cgggacatac ggagtcaact acccggccaa cggtgatttc 60
ttggccgccg ctgacggcgc gaacgacgcc agcgaccaca ttcagcagat ggccagcgcg 120
tgccgggcca cgaggttggt gctcggcggc tactcccacg gtt 163




493


80


DNA


Mycobacterium tuberculosis



493
ctcaagcttg actggccacc caccggcatg accaccgaca ggcccgactg gtcgtaccac 60
tcgaacgccg gggtgtttga 80




494


248


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






494
ttggtgcccg gaatggcgag tcccatttan tcgctgattt gtttgaacag cgacgaaacc 60
ggtgttgaaa atgtcgcctg ggtcggggat tccctctcca agcaagagta actggcccca 120
aataaagtta ctcgtcgtct tgcaaagacc gctacccgat gccatttatg tgtttcctta 180
cgctcnnnnt tccggtgcgc catcattatc tgcacctttg cactgcacat tgagcttagc 240
agcgctcg 248




495


341


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






495
gaattngctt tcggcgccat cggcccagga ccgcgtgcgg gtgctcaacg acgacgtcgt 60
ccgcgggaca cacctcgatg ctgccgccat ggacgcggtc gaacgcaagc agctgatcga 120
gctacaacgc cgcgcggaac gcttccgccg cgggcgtgac cgcatcccgt tgaccgggcg 180
gatcgcngtg atcgtcgatg acggcatcgc caccggagcg acggccaagg cggcgtgcca 240
ggtcgcccgg gcgcacggtg cggacaaggt ggtgctggcg gtcccgatcg gcccagacga 300
catcgtggcg agattcgccg ggtacgccga tgaagtggtg t 341




496


420


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






496
taaagctttc gtcagttcat ngngcccccg gaccaacaaa agcatcggga catacggagt 60
caactacccg gccaacggtg atttcttggc cgccgctgac ggcgcnaacg acgccagcga 120
ccacattcag cagatggcca gcgcgtgccg ggccacgagg ttggtgctcg gcggctactc 180
ccagggtgcg gccgtgatcn acatcgtcac cgccgcacca ctgcccggcc tcgggttcac 240
gcagccgttg ccgcccgcag cggacgatca cntcgccgcg atcgccctgt tcgggaatcc 300
ctcgggccgc gctggcgggc tgatgagcgc cctgacccct caattcgggt ccaanaccat 360
cnacctctgc aacaacggcg acccgatttg ttcggacggc aaccggtggc gancgcacct 420




497


135


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






497
ccgggaggga ccatcncggg cggctncggc ttctctccgg aaggttctan ngtnnngcgt 60
ttcnacnctt cccgtcgccc tgcgaccgcc gaacattcgg ggtatggnng cancctgtna 120
gcatccnggc cgggc 135




498


277


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






498
ctcaagcttc cgcatcagat cgctatagaa ccggtgcgcg tccccaccga gtggctggtc 60
gccttccagc acgatcgtta ccgcgttatc ggaatcaaac tcnccgaaca cctgaccaac 120
gcgcttgatc gcctgaatcg atgcggcgtc gctggggctc atcgataccg agtgtgcttt 180
tccgaccact tccagttgcg gtacggcgag attgacaaag gcggtgaagc ccagccagag 240
caggacgatc accnccgcaa accggcggat ttgcccg 277




499


323


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






499
gcttggcagc ctgcggctgg gcgccctnga gctcttcgat ctggatctcc ggactcgaga 60
tgctcacttg cccggccgtg gacgtaccca ttgcggccgg gaccccagcg ccccaggtga 120
ccagcgagtt gggctgcacg ctgaccggcc cgtcggggtc gacgccggta acggtcagca 180
gctccgangt ccnnctgatc ccgaccgcag ctgccaatgc gcggctggca gccgacgtgg 240
atgtgccggg gcctagatcg cggggcagca gcgagaccgc gtcaccgacg gtcatcacct 300
tgccgagttt nggcctgccg can 323




500


148


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






500
gcttccggct cgtatgttgt gtggaattgt gagcggataa caattncaca caggaaacag 60
ctatgaccat gattacgcca agctatctag gtgacactat agaatactca agcttgagcc 120
atcgggctat cagctggttg atgtcccg 148




501


242


DNA


Mycobacterium tuberculosis



501
caggcatgca agcttgtcgt ctatcacatc cgaccaccaa ccgcccgacg gctcggcaga 60
acgcctccgc atatgggtcg acgaccagcg ggtcggactt ctgggctgcc agcgctcgcg 120
ccgtcgcgac aaacagcgcg gtcgaaccga cactccttgt gatgtcccac ctatcacctt 180
cggtacgcac ccaatcgacc ctacgcggct agctcagccc cgatcttcca gagctccgcc 240
cg 242




502


230


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






502
gctttttgag cgtcgcgcgg ggcggcttcc ccggcaattc tactagcgag aagtctggcc 60
cgatacggat ctgaccgaag tcgctgcggt gcagcccacc ctcattggcg atggcgccga 120
cnatggcgcc tggaccgatc ttgtgccgct tgccgacggc gacgcggtag gtggtcaatt 180
ccggtctacg cttgggcctt tgcggacggt cccgacgctg gtcgcggttg 230




503


235


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






503
cgancctgtt cgacggctac ctgaatcacc ccgatnccac cgccgcggcg ttcgacgccg 60
acagctggta ccgcaccggc gacgtcgcgg tggtcgacgg cagtgggatg caccgcatcg 120
tgggacgcga gtcggtcgac ttgatcaagt cgggtggata ccgggtcggc gccggtgaaa 180
ttgaaacggt gctgctcggg catccggacg tggcggaggc ggcagtcgtc ggggt 235




504


152


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






504
naagctttgt cacaccaagt gtttcnacca gncgctccat ccggcgaagt ggatactccc 60
agcaggtagc aggtcgccac cacgctggtc agtgcgcgtt cagctcgctt gcggcgctgc 120
agcagccagt ccgggaaata gctgccctgg cg 152




505


192


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






505
cgctggncgc cggcgctggg ctgcggtaac caattaccac aacacttttc ggtagccgaa 60
cagcggcgcg taccagcgaa atggcacagc caccgcagtc gccgacatcc cgcgaagatg 120
tggcagattt tcgtgcggtc gagccggcga aggcctagcg tcattgttgc ctggcaaggt 180
tgctgggccc gg 192




506


312


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






506
ctcaagcttc ttctgcccct tgccgttncg gatnacatcc cgcagcgact cggcttcggc 60
gtcgatgtcg aagttctcga tcagcttctg gatcgactcc gcgcccatgg caccggtgaa 120
gtactcgccg tagcggtcga cnagttcgcg gtagaggttt tcgtcnacna tcagctgctt 180
gggcgccanc ttggtgaaag tgctccaaat gtcctccaac cggtccagct cacgctgcgc 240
gcggtcacgg atctggcgca tctcgcgctc gccgccgtcg cgaacttgcg ccgcgcatcg 300
gccttggggc cc 312




507


296


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






507
gttcacacct acctactatg ccncaattcn ccgacacggg tggcatcaac acgggcgata 60
aggtggaaat cgctggggtg aacgtcgggc tggtgcgctc gctggcaatc cgcggcaacc 120
gcgtgttgat cggattctcg ttgcccggca agacaatcgg gatgcaaagc cgggcagcaa 180
ttcncnccna caccattctt ggccgtaaga acctggagat cgaaccccgc ggttcggagc 240
cgttgaaacc caacggtttc ctgccgttgg cgcanaccac tacgccatac caaatc 296




508


208


DNA


Mycobacterium tuberculosis



508
ctcaagcttt acgccgacgc cggcctacac aacaccaagg aaacgattgc ctactgccga 60
atcggggaac ggtcctcgca cacctggttc gtgttgcggg aattactcgg acaccaaaac 120
gtcaagaact acgacggcag ttggacagaa tacggctccc tggtgggcgc cccgatcgag 180
ttgggaagct gatatgtgct ctggaccc 208




509


278


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






509
tcccncatgg gataacgggt ttagatttcn acaacggcac cgtgtttctc aacaagccgg 60
tcatcagctg ggccggcgac aacggtatct acttcacccg ctttcgcccg tacaagaaaa 120
accactaggc caccatcgag tccaagaaca accacctggt ccgcaagtac gcgttctact 180
accgctatga caccgccgag gaacgcgccg tgctcaaccg gatgtggaag ctggtcaacg 240
accgcctcaa ctacctcacc ccgaccatca aaccgatc 278




510


177


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






510
ctcaagcttg ggtgttgccg atcaccggaa gccncatgat cagccacgtt tcgcgccgcc 60
cggcatacgg cggcgtaccg atctccgcgt catacacccg cgggtaatcg ccgacggtgc 120
cggttcgcga gccgaaggtg acaacgctga ttgaatcnag ttccangtcc agcgggt 177




511


296


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






511
tnaacagctc gcggcagccc acgacctgct gcgtcggatt gccggcggcg agatcaattc 60
caggcagctc ccggacaatg cggctctgct ggcccgcaac gaangactcg aggtcacccc 120
ggtgcccggg gtcgtggtgc acctgccgat cgcacaggtt ggcccacaac cggccgcttg 180
atgnnnngtc ggcaagcccg gcagtngcca aacccagcgt gatcangctc ggctcgcgag 240
ttcggcgaan aagtggctcg cctgatcacc taccatcggc cangatctgc gtgtca 296




512


223


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






512
gccanccggc ttggcgtcga ctcccgttcn gcacatcata cggtccccgg tactgtccaa 60
ctgcgccggt gcgctagcca aacgtcacga ctctcagtga tcccagttcg tgatccggcc 120
ggtggcgccg ctgcggcggg ggctnatnta cttcggactn attatctcat ccaaaggaca 180
ccgggccggt ggctggaatc ccatggtgcg atcggccaca can 223




513


147


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






513
ccgacctggt atcttccgat agcgcgcgtt gatatccggt ctgatctcct gcccttaacg 60
ccggatctca gcaggtcccc atgcaaagat ccgaggtgtc ccngatctag gggtcctcgt 120
cctccagatg atggagcaag tcggccc 147




514


149


DNA


Mycobacterium tuberculosis



514
ctcaagcttc ggctcaggcg gcgctgccgg taacgtcgct gaccggtgca ggtttcgaca 60
atgtggtgcc ggttcggcgg ctacgtgcca tcaagacact ggcgcaggct atcgcacccg 120
ttatcggcta caaacaaatc gcggtatgc 149




515


238


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






515
catcacctgn ttcatgaact ggaagcaccg cagcgcttcc ttttcggccg caacatgagc 60
cagcctctcg tcggcggtcg ggtgcaggtg ctcgggcagc tcggccgcga cagccgcctg 120
accctgaaac cagcttccat atcccgcgac gaacgacgcc agtccgctac gtaacccctc 180
cgcgactgtc catggacaac agcgcgttct ccaccgaccg ggcccgggtg tggggtgt 238




516


175


DNA


Mycobacterium tuberculosis



516
agcttagctt cccgccccgg caatagggct ccagctcatc cggtgtgacc agataggggc 60
ccagggtgat accgctgtct ttgcccttgg cctgtccgat gcgcagctgg ccctccagca 120
tctgcaggtc ccgtgcggac cagtcgttga aaatggtata gccgatgatc gaccg 175




517


144


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






517
ccngaacaga agcggnggtt cctaccgcgg tgtgcggccg gcgcgatatc ggccttttta 60
ctaaccgaac ccgatgtggg ctccgatccg gcgcgcatgg catcgacggc gacgccgatc 120
gatgaccgcc aggcttacca cctt 144




518


174


DNA


Mycobacterium tuberculosis



518
ctcaagcttg cgcgactcga caagcattct tgacagttgt tttggctcgg catggttagc 60
caaggttctg cggtcccacc agatcatctt ggtccggtag cgctcgtccg ggtatgctgc 120
cgccgggatt ctcgctgcta ttactccccc cgaagaacgc caccggtcca gcgc 174




519


187


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






519
gcnaggcggt atagcttccc gtcgtaccgg cgaccgccag ccgagaagct cgttttccca 60
gtgttgctgg ggattctcac gctgctgctg agtgcgtgcc agaccgcttc cgcttcgggt 120
tacaacgagc cgcggggcta cgatcgtgcg acgctgaagt tggtgttctc catggacttg 180
gggatgt 187




520


215


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






520
gtgtggaacc gtgagcggat aacaatttca cacaggaaac agctntgacc ttgattacgc 60
caagctattt aggtgaggct atattaatac tcaagattgc ggtcgagcac atcggcccaa 120
gaaccgccga aggcacggcg gaacgcctgc ggcacatggg gcgacgacca gcgggtcgga 180
cttctgggct gtccagccgg atcgcgccgt cgcga 215




521


406


DNA


Mycobacterium tuberculosis



521
cactgtcagt acatatgcgc cgctcctcct catcgctgcg ctcggcatcg tcgccggcgg 60
tcatggcgtc accctaccca agccgaacgc gaaacgagaa cgtgttccat tattagggtg 120
tgagcaccaa taccagattg ctcaccagga actcacgcag caccgggacg gatgtcagcc 180
accacgccca tctggggtgg tagcggggaa atacggctaa cgcggctccg gtgccggcag 240
cccagcgcag accctcggcg gcggacacgg caaacaacga cgacccatag ttgttctttg 300
ccggatggcc gtgtttgcgg acatatcggg cggcggcgcg ggcgccgccg aggtagtggc 360
tgaggcccat ctcgtgcccg ccgaatggcc ccagccaaac cgtgta 406




522


180


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






522
ctcaagcttt tacggtgatc gcgcatcacc tggttcatga actggaagca gcgcagcgct 60
tccttttcgg ccgcaacatg agccancctc tcgtcggcgg tcgggtgcag gtgctcgggc 120
agctcggccg cgacagccgc ctgaccctga aaccagcttc catatcccgc gacnaacgac 180




523


69


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






523
ctcagaagcc gctagctggt agagtcgctg accggtgcac gtggcgncaa tgtgcgctgc 60
cggttcgcg 69




524


168


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






524
ctcaagcttg cgctcatcaa gcgcgaacag cagggcggtc ggctggtcgc catgacgggt 60
gacgggacca atgacgcacc cgcgctcgcg caagccgatg tcggggtggc natnaatacc 120
ggcacccagg cggcccggga agccggcaac atggtcnatc tccactcc 168




525


83


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






525
acttctattt cgactggtgt gctgtggcgc gatccgactg ccggcgtggt caaggccggc 60
cagttgtggg atnccacagg cac 83




526


173


DNA


Mycobacterium tuberculosis



526
gcttgtcgta ttccgtggca ctgtcagaca tatgcgccgc tcctcctcat cgctgcgctc 60
ggcatcgtcg ccggcggtca tggcgtcacc ctacccaagc cgaacgcgaa acgagaacgt 120
gttccattat tagggtgtga gcaccaatac cagattgctc accaggaact cac 173




527


38


DNA


Mycobacterium tuberculosis



527
cgatattcgt cggccgcgtt gtctcgactg ggtcgcgt 38




528


136


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






528
gacctcggcc accaagccgg acgcgaccgt cgaggtggcg atccggcttg gcgtcgaccc 60
gcgtaaggca gaccacatgg tccgcggcac ggccancctg ccacacggca ctggtaagac 120
tgcccgcgtc gcggcn 136




529


114


DNA


Mycobacterium tuberculosis



529
ccggaagtct aggggacgac ctactcagcg caaaatgtcg ctaatgtgag tccgccccac 60
cagggcagat caacccatgt cgatgatgac ctacccggat accggattgg cggt 114




530


119


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






530
agcttcagtt cctccacgac gcgttcccaa atgaatttcc cgatcccaca atctcggttc 60
agatacaggt cgccataccc cttacttcgg naacgctggg cggattggcc ctgccgctg 119




531


99


DNA


Mycobacterium tuberculosis



531
ccgcctacgg gtcgaacatg catcccgaga ccgatgctcg agcgcgcacc ccactcgccg 60
atggccggaa ccggctggtt acccgggtgg cggctgacc 99




532


308


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






532
gcggctggtt acgactccct gtttgtgatg gaccacttct accaactgcc catgttgggg 60
acgcccgacc agccgatgct ggaggcctac acggcccttg gtgcgctggc cacggcgacc 120
gagcggctgc aactgggcgc nttggtnacc ggcaatacct accgcagccc gaccctgctg 180
gcaaagatca tcaccacgct cgacgtggtt agcgccggtc gagcgatcct cggcattgga 240
gccggttggt ttgagctgga acaccgccag ctcggcttcg agttcggcac tttcagtgac 300
cggttcan 308




533


328


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






533
gcctttccgc acaatctgta ccccaggacc ntctaaaaaa tcgaatacga cggcgtcgcc 60
gactttccgc ggtacccgct caactttgtg tcgaccctca acgccattgc cggcacctac 120
tacgtgcact ccaactactt catcctgacg ccggaacaaa ttgacgcagc ggttccgctg 180
accantnntg tcggtcccac gatgacccag tactacatca ttcgcacgga gaacctgccg 240
ctgctagagc cactgcgatc ggtgccgatc gtggggaacc cactggcgaa cctggttcaa 300
ccaaacttga aggtgattgt taacctgg 328




534


75


DNA


Mycobacterium tuberculosis



534
gcagaccaac aagatgcatc gggatcatac gccgtcaact acccggccaa cggtgatttc 60
ttggccgccg cccac 75




535


319


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






535
ctcaagcttg ccaaagagac ctcgtccacc aagcnggacg cgaccgtcna ggtggcgatc 60
cggcttggcg tccacccgcg taaggcanac canatggttc gcggcacggt caacctgcca 120
cacggcactg gtaanactgc ccgcgtcgcg gtattcgcgg ttggtgaaaa ggccgatgct 180
gccgttgccg cgggggcgga tgttgtcggg agtgacaatc tgatcganag gattcagggc 240
ggctggctgg aattcgatgc cgcgatcgcg acaccggatc agatggccaa agtcggtcnc 300
atcgctcggg tgctgggtc 319




536


312


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






536
ccacggcgtg gatcaaggta ccggccggga tgttgcgcaa tggcaggttg ttgcccggct 60
tgatgtcggc gttagcgccg gattccacca catccccttg cgaaagtccg ttgggtgcaa 120
tgatgtagcg cttctcccca tcgagatagt ggagcaacgc aatccgtgcg gtacggttcg 180
ggtcntactc gatgtgcgcg accttggcgt tgacaccatc tttgtcattg cggcgaaagt 240
cgatcatccg gtaagcgcgc ttatgaccgc cgcctttgtg ccgggtggta atccggccat 300
gcgcgttgcg tc 312




537


105


DNA


Mycobacterium tuberculosis



537
ggcggctgcg tcggcgagat gatcgcccgg tgccaccccg atccgtgcct cggtcagcgc 60
caacgtgctt tccggtccgg cgaccaccat gtcgcatgcg ccgac 105




538


144


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






538
gcaatcgcct tggcggtcgc cgggttgtca ccggtgatca tcncggngcg gatgctcatn 60
cggcgcattt cgtcnaatcg ttcccgtatg cccaccttga cgatgtcctt catatggacc 120
acgccgatgg cccncgcgct nctg 144




539


431


DNA


Mycobacterium tuberculosis



539
ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg aaacagctat 60
gaccatgatt acgccaagct atttaggtga cactatagaa tactcaagct tccacatcgg 120
tatgccaaag cattgcgccg ctatcgattt cgcgctggca tcgccaaggt ggacttcttg 180
ctcagcgacg agatcccgtg gtcggatccg cggctgcggc gggctgcgac cctgcatctc 240
ggcggcaccc gtgaccagat ggcgcgcgcc gaggcagacg tcgcggcggg acgccacgcc 300
gactggccga tggtgctggc cgcgtgtccg cacgtcgccg accccggccg catcgacgaa 360
accggccgcc gtccgttctg gacctatgcc cacgtgccgt cggggtccac gctcgacgcg 420
accgagaccg t 431




540


462


DNA


Mycobacterium tuberculosis



540
cgcgtccacc gcagcgtgag attggtggcg ccattcgtcg tggtgtagct gctgttggcg 60
gcgtcgccgt attgtgcggg ccagccttgt gcgggggccg cttctaccca cgagtcggca 120
cttccgcaac cgcccagctc gaccgcgatt acggcggccg caacggccgc cggaaggcgt 180
ctcgcaagcg ccttatcctt tcgcaggttc ccagatcctt ccgctacgtg ggtcgctcat 240
cggcgggccc ggccgaatga gtacaggtga gggtaaccgc tacaaatgaa gttggtcagt 300
gctggccaac tgtgtaatgg ttgcccggct cgggtcacca cgtacattct ggcaaggcgg 360
gcgagattcg gttcctcgcg tccttggccg gtggcggttc ccggttgtcc gtgggcgtgt 420
cgtgtacgtg gtgtaagtgt cgtgaactcc tcagtttggg ct 462




541


307


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






541
ctcaagcttg cgctggatct ggcggctgag cctgttcttg ggcaacatgc cgagggatcg 60
ccttttccac cacgcggtcg gggtggcgtt gcattagctc accgatggtg cgcttgtgca 120
ggccgccggg ataccccgag tgccggtaaa ccatcttgtg ctgcagtttg tcgccgctga 180
tggcgacctt gtcggcgttg atcacnatga cnaagtcacc gccatcgaca ttgggggcga 240
acgtcggctt gtgcttgccg cgcagcaggt tggccgccgc gacggcaagg cggccaanca 300
ccacgtc 307




542


333


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






542
tttgggatgg gcaaaaaggc gaagcnccgc gtggccacga acgccgggag ggacaatctc 60
gggcggctag ggcttctcgc gggaaggccc gaacgtacgg cgtttcaaca cgtcgcgtcg 120
ccctccgacc gcgaacattc ggggatggca gcaacctggt agcaccctgg ccgggcgatg 180
atctgcagcg tcgccgcggg tagtcgccgc ccgggcggct acagtctgaa acgcgatgac 240
catcgatgtg tggatgcagc atccgacgca acggttccta cacggcgata tgttcgcctc 300
gctgcgccgg tggaccggtg ggtctatccc gga 333




543


234


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






543
ctcaagcttc gtcataagac catggtgcgc tttctttcac ccgtccanag tcgggggcat 60
ccgcaccggc tcgcatcgca tcatcctccc acgacgggcc gctcatcagc ttgggccatt 120
tcaatgtact tgataccccg cgctgcgggt aggccactgc nacaattcaa acacggtgtc 180
acacggtgaa tantgtcnan atgggctctg atcaaccgtc ncaaacccgg tttc 234




544


440


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






544
gaattctgcg tgcaccgcta tgggttgcag cagcggctgg cgccgcacac cccactggcc 60
cgggtgtttt cgccccgaac ccggatcatg gtgagcgaaa aggagattcg cctgttcgat 120
gctgggattc gccaccgcga ggccatcgac cgattactcg ccaccggggt gcgagaggtg 180
ccgcagtccc gctccgtcga cgtctccgac gatccatccg gcttccgccg tcgggtggcg 240
gtagccgtcg atgaaatcgc tgccggccgc taccacaagg tgattctgtc ccgttgtgtc 300
gaagtgcctt tcgcgatcga ctttccgttg acctaccggc tggggcgtct gcacaacacc 360
ccggtgaggt cgtttttgtt gcagttgggc ggaatccgtg ctctgggtta cagccccgaa 420
ctcgtcncgg cggtgcgcgc 440




545


425


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






545
gcagttggga atcgctctgc agcaaaccan tattctgcgc gacgttcgag aggactnttt 60
gaatggacgg atctacctgc cgcgcgacga gctggaccga ttaggcgtac ncctccgcct 120
ggacgactcc ggggcactcg atgaccccga cggacggctc gcggcactgc tgcggttcan 180
tgccnaccgc gccgcanact ggtattcgct gggactgcgg ctgattccac acctcgaccg 240
ccgcagcgct gcctgctgtg cggccatgtc tggcatctac cgccgtcngc tcgccttgat 300
cagaccatcg ccggcggtcg tctaccatcg gcgaatctct ctgttcggga ctgaanaang 360
cccaagtggc ggcggcagca ctggnctctt cggtaacctg cngaccgccc attggaccgc 420
taccg 425




546


401


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






546
ttgatctgga cgtctgagac ggtgatcggn ccgaacctga attgtccggt aatgcccagc 60
gcagaaagca nggtggtggc cggggcggtg aanccggcgt cggcggcacc gtcgaagtcg 120
atgtggattg ccggaatggg gatgtccggc acggcgaagc cgtagttcgc ttgtcccgtg 180
aggcccangt ggatgggggg aaggatcgtg gtgtccggga tgataatggg gccgatgccg 240
ccggttgaag tccagtggat cgggaattcg ggaatcgtga tgccgacgtt caggccgaac 300
aggccctcca agttgcctcg ccacnagatg ccgttgctga agttgcccga catgagggcg 360
ccggtgtcca cattgcccga attggcgacg ccggtgttgg c 401




547


391


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






547
cacgtaggcg ccgtccataa atnactccgc cgcgcttcgc acatcctcgt ancgatcctt 60
ggcgagcagg tcaaccgggc gctgcccgtc naggagccgg tttttggcgt gcagccactg 120
gccgacacct cggggggtaa gcgaatccga gagcaggagg acnaggtcac gaanctgcgc 180
cagccggtcg taccgctcag ggcggatgtc gccggtccgc cacccgcgta ccgcccgatc 240
ggacacctgt atgaccgcgg cgacntcgac ctgggtgacg ccgaagggtt tcagggcatc 300
nacnatctcg ctggcctcga ccgcccggtc cagggtgacc gccatcgtgg ttcctccgca 360
acttccggtt ctactaccgt aaacgctacc g 391




548


369


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






548
cggggaacgg tcctcgcaca cctggttcgt gttgcgggaa ttactcggac ancaaaacgt 60
caagaactac gacggcagtn ggacagaana cggctccctg gtgggcgccc cgatcgagtt 120
gggaagctga tatgtgctct ggacccaagc aaggactgac attgccggcc agcgtcgacc 180
tggaaaaaga aacggtgatc accggccgcg tagtggacgg tgacggccag gccgtgggcg 240
gcgcgtttcg tgcggctgct gggacncctc cgacgagttc accgccggga ggtcgtcgcg 300
tcggccaccg ggcgaatttc cggttcttcg ccgcgccccg ggatcctggg accgcnggcg 360
cgcgctgtt 369




549


85


DNA


Mycobacterium tuberculosis



549
ctcaagcttt gtccgacaag cgttcccggg cggtcagcaa gcgaacgtcg gttggcccac 60
tgcgggtcga tattgccgcc aggga 85




550


101


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






550
cgtcagcacg gcgacgtcgc gntacgccga gcagttacac aatcgctctg cagcaaacca 60
atattctgcg cgacgttcga gaggacttct tgattggact g 101




551


458


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






551
ctgcatccgg ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac 60
agctatgacc atgattacgc caagctattt aggtgacact atagaatact caagcttcgc 120
gcagcggcgg gttgacccgg ttcacgccgt catagctggc caatctggca tcgtcgatca 180
ncatgtggtg gggggtgacc tcggcggtga tcgaaatacc ctggtcctta tcccatttca 240
ggatttcgac ggtgcccgcg gccgacgcgt gacagatgtg cacccgggcg ccggcgtcac 300
gggccagcaa ggcgtcgcgg gcgacgatcg attcctcggc ggcccgcggc catcccgcca 360
ggcccagccg cgccgccatg ggtccctcgt gcgcgacggc gccgaccgtc agccggggct 420
cctcggcgtg ctgggcgatc agcacgccca aaccggtg 458




552


463


DNA


Mycobacterium tuberculosis



552
ccgacgcgca ctacgtgctg gtgtccaccc gcgacccgca ccggcacgag ctacgcagct 60
accgcatcgt cgatggcgct gtcaccgagg aacctgtcaa tgtcgtcgag cagtactgaa 120
ccgttccgag aaaggccagc atgaacgtca ccgtatccat tccgaccatc ctgcggcccc 180
acaccggcgg ccagaagagt gtctcggcca gcggcgatac cttgggtgcc gtcatcagcg 240
acctggaggc cagctattcg ggcatttccg agcgcctgat ggacccgtct tccccaggta 300
agttgcaccg cttcgtgaac atctacgtca acgacgaaga cgtgcggttc tccggcggct 360
tggccaccgc gatcgctgac ggtgactcgg tcaccatcct ccccgccgtg gccggtgggt 420
gagcggacac atgacacgat acgactcact gttgcatgcc ttg 463




553


453


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






553
tgcttccggc tcgtatgttg tgtggaattg tgagcggata acaatttcac acaggaaaca 60
gctatgacca tgattacgcc aagctattta ggtgacacta tagaatactc aagcttgccg 120
ggagggtgca tggccgactc ggatttaccc accaaggggc gccaacgcgg tgtccgcgcc 180
gtcgagctga acgttgctgc ccgcctggag aacctggcgc tgctgcgcac cctggtcggc 240
gccatcggca ccttcgagga cctggatttc gacgccgtgg ccgacctgag gttggcggtg 300
gacgangtgt gcacccggtt gattcgctcg gccttgccgg atgccaccct gcgcctggtg 360
gtcgatccgc gaaaagacga agttgtggtg gaggcttctg ctgcctgcga cacccacgac 420
gtggtggcac gggcagcttt agctggcatt cct 453




554


466


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






554
ggaaacaccg ncgccgtcgt ggccaccaac accgcgacca gcaccgtgac ccggaccggg 60
gtgccgcgcg aaccggtctt ggccaattgc cgcggcacca agccgtcgcg cgccatggcg 120
aacagcacgc ggcattgccc gagcatcaac accatcacca ccgtggtaag cccggccagc 180
gcgccgacgg agatgatgcc gctggcccag tacaccccgt tggcctggaa cgcggtggcc 240
agatttgccg gcccgcggcc cggtacggtc cgcagttggg tgtatggaac catgcccgac 300
agcaccaccg ataccgcgac gtagagaagg gtcacgaccc ccagcgacgc gagaatccct 360
cgagggacgt ctcgttgagg acgcttggtc tcctcggcca tggtggccac gatgtcaaac 420
ccgataaacg cgaagaacac gatcgatgcc cggccagcac gccgta 466




555


466


DNA


Mycobacterium tuberculosis



555
cctgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa 60
cagctatgac catgattacg ccaagctatt taggtgacac tatagaatac tcaagcttgt 120
cctcgggcgt ggcctcggcc aagaaatcgt cgacgccggc ctcctgtgca atcgccttgg 180
cggtcgccgg gttgtcaccg gtgatcatca cggtgcggat gctcattcgg cgcatttcgt 240
cgaagcgttc ccgtatgccc accttgacga tgtccttcag atggacgacg ccgatggccc 300
gcgcgctgct gttatcggtc cattccgcaa cgactagggg tgtccccccg ccggagctga 360
tgccgtcgac aatggcaccc acctcctcag tggggtggcc accgtgatcg caaaaccact 420
tcatcaccgc agccgcggca ccttgcggat ccgaacggat gcgctc 466




556


467


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






556
ttcgttcgat ggcgccgccc cggctacggt ttgacctgtg ggtgtcgaat tggggtcaaa 60
ttccgaggtc ggcgcgctaa gagtggtcat cctgcaccgc ccgggggccg aactgcgccg 120
gctcacaccg cgcaacaccg accagctgct gttcgacggc ctgccctggg tatcccgcgc 180
gcatgacgag cacgacgaat tcgccgagct gctggcttcc cgcggtgcgg aagtgctgtt 240
gctgtcggac ctgttgactg aggcactaca tcacagcggg gccgcccgca tgcaggggat 300
cgccgctgcc gtcgacgcac cgcggctggg actgccgctg gcgcaagaac tttcggccta 360
cctgcgtatc tcgacccaag cangttggcg catgtgctga cgccggcatg acttcaacga 420
actcccntcc gacacgccga acgaagtgtc gttggtgttg cgtatgc 467




557


142


DNA


Mycobacterium tuberculosis



557
gcggcgagtg tggtgggtgc cgaacacgaa tccaacgacg cactggcgga gagataccac 60
ttgctgtact ggaagcacgt gctgatgatc tcccgtggaa tgtgcctcgc cgccgtctat 120
cgaaaacagt gagcatgctg cg 142




558


217


DNA


Mycobacterium tuberculosis



558
caaccgcgct cggcgcgtct gggccttccg ccggctccgc cgacaattct atctctggat 60
cagcggggct ctccgggccg gcctccgcga actcaacagg ccgcgccttc cggccgaaac 120
attccctagc catatatgat cgcacctcga tacacgatct ggcggcaaca ccgcaaagcg 180
tccgacgggc ccaacctccg caattcaggt atccggg 217




559


147


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






559
gaaggtcggc gaaggtgtgg ctggntgccg atcacgaatc caatgatgca gtggtcggaa 60
gatattagcc acttgctgtt ctggagacag gtgctgatga tctcccgtgg aatgtccctc 120
gactccgtct atcgaaatct gtgaaca 147




560


177


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






560
tcctgcgctc tgggccattc tcgggtctgc cgacaattct atctctggat ctgtggggct 60
ctcttggccg gcctcngcga tctcttcang gcgcgccttc cggccgaaac attccctatc 120
catatatgat cgcacctcta tacaccgttt ggcggcaaca ccgcaaagtg tctgtcg 177




561


128


DNA


Mycobacterium tuberculosis



561
agctttacgc tggcgtatca gcgttggggc cgctgccatt tcggtcgccc aacgcgttgc 60
cagctccctg cgctgtcagg gcttgcgcgc caaactggcc accgcaacaa acttggctga 120
gcttgatc 128




562


142


DNA


Mycobacterium tuberculosis



562
ctctatctgg cgtcacattc gcaatcttta gattgcagat atcgataaaa tcacccgcgc 60
gacaagaccg ccatgtcatc ctttcgatgt tatttcgccg gcctggggaa agcgcaacga 120
cgttgcctac acgttccgcc gt 142




563


406


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






563
agctttncct tgcatctgca ccccgatcca cgtcagccac gtcggcgttc tccaccaaga 60
agttgcgggc attctccttg ccctggccga gctgctcgcc ctcgtaggtg aaccaggcac 120
ccgacttgcg gatgaggccc tgatccacac ccatgtcgat cagcgagccc tccctgctga 180
ttcccttgcc gtagaggatg tcgaactcgg cctgcttgaa ggggggcgaa cagttgtgca 240
cgacaacccc ttcggcgacg agggtgtgca gttcctcgac ctcgaggtcg aacgttcgtg 300
cccgccgcgt tggcagcact tctcggatca cggaatagcg ganttcttcc gccagcatgt 360
cgtgcaggaa tttgtcatcc agggcatccg cgagcgcctg cacgcg 406




564


311


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






564
actgtcnagg gaatgcttcg cagcatctac ctgcagtcgc ttgtgcataa gcggacggcc 60
cnacctgttc gtgttccggg acaccagacg cgggagcacc ggcagtacgg cgaaaggttt 120
gagcggaagg agttgcgcaa atcggggcgc cccaacaccc gtccgcaaga cgcggtcaac 180
gacctgtttc aggcgatcag ggtcaccgac tcacctgcac tgagaacaag cgatctgctg 240
atctgccaga agatggacat gaatgtccac ggcaagcctg atggcctgcc gctcttccgg 300
gaatgtttgg c 311




565


310


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






565
tgaattatga tcccgacaca actgcatcan tttagccgcg tcgngatgct atccgccgac 60
ggtttgganc nggtccgtgt cgttcgtgtt gatctcaccc gaagttgtgt ccgccgccgc 120
cggggatcta gcgaacgtgg gatcgacaat cagcgccgcc aacaaggcgg cagcggctgc 180
gaccacgcag gtgctggccg cgggcgccga tnaggtgtca gcgcgcatcg cggcgctgtt 240
tggtatgtac ggcctgnaat atccggcgat cagtgcgcaa gttgccgcgt atcaccanca 300
gtccgtgcag 310




566


326


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






566
aacggggacc ncaagaaacc attcaanaac gaggggtcgt caccaacgtc gaaaccgacg 60
gttgccagcc ggcccacgat attgcgtgct cgagggtccg ctgtaccctc accgaacgtg 120
agtcccacac cgcggaggcg ggcgactctg gcgtcgttag cagccgagct caaggtgtcc 180
cgcaccactg tctcgaatgc ttttaaccga ccggatcagc tctccgccga tctacgtgaa 240
cgagtgcttg ccacggccaa gcgactgggc tatgccggac cggatccggt ggcgcgatcg 300
ttgcggaccc gcaaagccgg tgcggt 326




567


374


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






567
agctttggag ccncnccgan ccnccggtac gccccgccac cgccgtaccc ggcacccgac 60
ccctttgagc cgttcgccgt ggccgcggtg ganctggccg acgagggact gatcgtgctg 120
ggcaaagtgg tcgatggcac gctggccgcc gatctgaagg tcggcatgga gatggagctg 180
acgaccatgc cgctgttcgc cgacnacgac ggtgtgcagc gcatcgtcta cgcgtggcgg 240
atcccatcgc gcgccggcga cnatgcanag cgcancgatg ctgaggagcg gcgccgatga 300
ggatgagcgc gccggaaccc gtttacntcc tgggtgccgg tatgcacccg tgggggaaat 360
ggggtaatga cttc 374




568


422


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






568
ttctcncatc gttcgtactn ngatgggacg ctgctgcccg aggcgatcct ggccaaccgg 60
ctctcgccgg cgctgacctt cggcggggcg aacctgaact tctttccgat gggcgcttgg 120
gccaaacgta ccggggctat cttcattcgg cgtcagacga aagatattcc cgtctaccgc 180
ttcgtattac gtgcttacgc cgcgcagctg gtgcaaaacc atgtcaacct cacctggtcg 240
atcgaagggg gtcggaccag aacgggcaag ctacggccac cggtgttcgg gatcctgcgt 300
tacatcaccg atgcggtcga cgaaatcgac ggtcccgaag tgtatttggt gccgacctcg 360
atcgtgtacg aacagctgca cgaagtggaa gccatgacca ccgaagccta tggcgccgtg 420
aa 422




569


300


DNA


Mycobacterium tuberculosis



569
ttcttccggg taccgctgat cggcggcacc atcacgcacc cggtgcaggg cgaggcggcc 60
gccggtgtgg tgttgctacg gccggccagc ccgggtaccg gtgtgatcgc cggtggtgcg 120
gcccgcgcgg tgctggaatg tgcgggggtg cacgacatct tggccaagtc gctgggcagt 180
gacaacgcga tcaatgtggt gcacgccacc gtggccgcgc tcaagctgct gcaccgtccg 240
gaggaggtgg cggcgcgccg cggtttgcca atagaagacg tccccccggc cgggatgctg 300




570


343


DNA


Mycobacterium tuberculosis



570
gtcgaaagtg accatctcta ccttgagtgc cataccgccc gaccctatgc ctcggatagc 60
tcggcggaaa gaaacgcttg cagtgccgcc gaataggcgg ctacgtcgtg agcgcccatc 120
aactctcgcg cggagtgcat cgccagctgg gcggcgccga cgtcgaccgt ggggattccg 180
gtgcgcgccg cggccaacgg cccgatcgtc gacccgcacg gcagatcggc gcgatgttcg 240
taacgctgca taggcactcc cgcgcgctgg caggccagtt gcgaaacgcc cccgccgggt 300
gccttccgtc ggttggcttt accgcaaatt tggggttgcc cct 343




571


220


DNA


Mycobacterium tuberculosis



571
aaagccacgg aaacgattgc ctactgccga atcggggaac ggtcctcgca cacctggttc 60
gtgttgcggg aattactcgg acaccaaaac gtcaagaact acgacggcag ttggacagaa 120
tacggctccc tggtgggcgc cccgatcgag ttgggaaact gatatgtgct ctggacccaa 180
gcaaggactg acattgccgg ccagcgtcta cctggaaaaa 220




572


254


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






572
tttcgccacc gcnaggtcgt gcgcgttcca gaaaagcgtg gtttcgccgg gcgcgaggat 60
tcgacggtcc aactgaccag ccggtcccgc cacccgttag gcaggatcgc ggtgtctata 120
tgttcgccct cggcataaac gccattgctg cggtgaaaat cggacatctc gccgattgcc 180
acgtctacat gatccgcttt gtcccgcgcc gggtcgttga caaacgcgat gtcngcctcc 240
tgggaagcgg tggc 254




573


329


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






573
tcgccaagtg gattcgtgct caccnacgag atccgtggtc ggatccgcng ctgcggcggg 60
ctgcgaccct gcatctcggc ggcacccgtg accaaatggc gcgcgccgaa gcagacgtct 120
cggcgggacg ccacgccgac tggccgatgg tgctggccgc gtgtccgcnc gtcnccgacc 180
ccggccgcat cnaccaaacc ggccgccgtc cgttctggac ctatcccacg tgccntcggg 240
gtccacgctc gacgcgaccg anaacgtaac cagcgtcctc gancggttcg cccccggctt 300
ccgtgacatc gtggtggcgg ccgcgccgt 329




574


297


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






574
gtaccgtcac catgatcgcc cccatcggca tcggtgagct gatagatccc agccggtttc 60
gccaaccccg gagcgatctt ggcgcgctgc tngtngtcnc tganacntag ccaccaacag 120
agcccggtgt gcgacaagan gactgatcgg atctctccgg acacntcgag ggggtcntca 180
ggagnccggg cgccaccccg aggtaagcct ccgcccagcc tcacaccgcg accgggtatc 240
ncaagtcgcg caataanccc accacctcct cggaccccac gttgtatgcg gctgggt 297




575


401


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






575
atactcaagc ttagacctca ctgatgtggc gggacgcggg agataaccgc ggttcgagcc 60
gttcaacagt ggtggttccc acaccagttg tttgcctttg cgaagtaaag cgattcgatt 120
tgctcgaaaa gagggctggc tgctcgtgag ggacatccat ggccgatacc tcagcgatct 180
caacggtcaa gcgactgcat gtttggcgca aggtatcgct aagcataggt tcgtgacgga 240
tttgacagca agagctttcc aaagattgct gtccacatan tgattcgcat ctctacacct 300
cttcgccggt gctgtcaaga gccattcgaa tcagttatct cgctcgtgct tggaanaaat 360
tttcccagcc tgcgttggac aaaccgcgtc gccaaagcgg t 401




576


453


DNA


Mycobacterium tuberculosis



576
agcttcccga gaaacagtgc attccctaag cagcccgttg tcacgccgat gagtgaagag 60
tgcacgcaat cgccggaatc cggcaaagcc ctgcacaagc gaaatcaacc cggaggctga 120
caaggcaacg tcggtgatcc gtaccgcctg gttggacaaa cggcagaagg cggcctcgtc 180
cggtccatct acgccgagca cactggtgat agcgcgcatc ggcatcggtg cggccacggt 240
ggagacgacg tccgcgggcg tctgggtcag taacccgccg accagttctc gggcaagctg 300
gtcgaccatc gggcgccacg tctccaacgc gccacgcgcc atacctggtg ccagttgctt 360
gcgcatccgg gtgtgcgccg gcggatcgga cgtcgcagaa acgcagccac cccgtgagaa 420
gtgacccacg gcgctggaca cgtgtctggt tac 453




577


474


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






577
cggccgggat gtgcgcaatg gcaggttgtc gcccggcttg atgtcggcgt tagcgccgga 60
ttccaccaca tccccttgcg aaagtccgtt gggtgcaatg atgtancgct tctccccatc 120
gagatagtgg agcaacgcaa tccgtgcggt acggttcggg tcgtactcga tgtgcgcgac 180
cttggcgttg acaccatctt tgtcatggcg gcgaaagtcg atcatccggt aagcgcgctt 240
atgaccgccg cctttgtgcc nggtggtaat ccggccatgc gcgttgcgtc caccgcgacc 300
gtgcagcggg cgcaccagcg acntctccgg ggttgaccgg gtgatctcgg cgaaatcaga 360
tacgctggcg ccgcgacgac caggcgtcgt gggcttgtac ttgcgaattg ccatggtcta 420
atcaggtctt tctctcacct ctcgtcgccg ggctagggcg cattgcctgc tcct 474




578


357


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






578
tagcggtgta accaactccc gggtcaccac ccgcaaacct cttgcggcaa cagcaccgtc 60
gacgcgtcaa ccgggctgcc cggaatcctg tggatgggca tcgagtgcat ggtcacgacg 120
tccccgacgc ggccggtggc aacgacaagt ggcccggatg caccacaaat gacggccgca 180
caccggtggg gacggccagc acgagagccg tgtcgccgaa gtcgacgcta atgccgtagg 240
cattggccgt cacaacaggc gacgccccgc gtaccaccga gtccacggng gttgggcggt 300
ctcctcggcc aaccaggcgt gaacccggcg gatccgaatg cagcaagacc cgtgggc 357




579


269


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






579
ccattggtcg gtgtgcgcat accantacna cgcgccgggc acctgacgcg gcggccgcaa 60
ccattcggtg gccatcgcca tcgtctgcca cccggtcaac ggacgcacct tctcctggcc 120
gacctagtgc gcccacccgc cgccgttgcg tcccatcgat ccggtcaaca tgagcagcgc 180
caacaccgag cggtacatga catctgctgt ggaaccagtg acanattccg ccgcccatga 240
tgatcntcga ccgtcctccg gattcggtc 269




580


272


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






580
gccggcctgg tcaaaggggc gtccgaagga nccgggctgg gtaacaagtt cctggctcat 60
atccgcgaat gcgacgccat ttgtcaggtg gtgcgggtgt tcgtcgacga cnacgtgact 120
catgtcaccg gacgggtcga tccccagtcc gacattgagg tcgtcgagac cgagctgatc 180
ctggcagatc tgcaaaccct ggagcgggcc acgggccggc tggagaanga agcncgcacc 240
aacaaggcgc gcaagccggt ctacgacccg gc 272




581


373


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






581
gatccactga ccacgatgac atatcgaaat gctcgacgat tccgatggcg atcaaggcca 60
cgatgccctg gccgttgggc ggtatctggt ggatggtgta cccgcggtag gttcccgtga 120
tcgtgtcgac ccagtccacg cgatgggcgg cgaggtcgtc ggcacgcatc accccgccgt 180
ntgccgccga gtgcgcctcg agtttggcgg ccagctctcc ccggtagaac tctcaccgtt 240
ggtcgccgcg atcttctcta ncgtcgccgc gtggtcagga aaggtaaaca gctcaccggg 300
tttcggcgct cgtccgccgg gcatgaacgc atctgcgaat ccgggctggg atgcgaacaa 360
cggacctgtg ccg 373




582


314


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






582
tctactgccg aatcggggaa cggtcctcgc ccaccnggtt cgtgttgccg gaattactca 60
ggacaccgaa acgtcgagaa ctacgagcgg agttggacan aataccgctc ccnggtgggc 120
gcccccatcg anttgggaag cngaaatgtg ctctggaccc cacccaagaa tgacattgcc 180
ggccgccctc caactggaaa tagaaacngt gatcacccgc cgcgttcttg gaaggaatgg 240
catgccctgg gccgggcgtt ccttccgctg ccggactcct cccaccaatt caccgccgaa 300
ggcgtcccgt ctgc 314




583


135


DNA


Mycobacterium tuberculosis



583
atactcaagc ttctgtcacc gaaatcccgc atgggataac gggtttagat ttcgacaacg 60
ggaccgtgtt tctcaacaag ccggtcatca gctgggccgg cgacaacggt atctacttca 120
cccgctttcg cccgt 135




584


221


DNA


Mycobacterium tuberculosis



584
ctggctcaag cgctcggcgc gcaggtgaac tcggaccggc tcgacgtcgc cgaacgcgag 60
gcggtgctgg cccacgccga cgccgtcgtc gcacatatcg gcaccgtgca caagtctaca 120
acaacgccgg catcgcgtac aacggcaacg tcgacaagtc ggagttcaag gacatcgagc 180
gcatcatcga cgtcgacttc tggggcgtcc tccacgggcc c 221




585


70


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






585
ccgccctccg cattatgggt caagaaccat cgggtcggac ttctgggctt ccaacgctcg 60
cgccgtcccn 70




586


241


DNA


Mycobacterium tuberculosis



586
ccgtggcact gtcagacata tgcgccgctc ctcctcatcg ctgcgctcgg catcgtcgcc 60
ggcggtcatg gcgtcaccct acccaagccg aacgcgaaac gagaacgtgt tccattatta 120
gggtgtgagc accaatacca gattgctcac caggaactca cgcagcaccg ggacggatgt 180
cggccaccac gcccatctgg ggtggtagcg gggaaatacc gctaacgcgg ctccggtgcc 240
g 241




587


492


DNA


Mycobacterium tuberculosis



587
tactcaagct tgtccaaata tcgaagcgtc gggtcgcgag gctcggtcgg cagctccagc 60
aaaacccgct ccacccctag atgccggtat ccctcaaggt ctttatccgc cgcttcaccc 120
cactggcaca cggtcaccgg cacgtcgccc ccggccatgg cgcgcaaccg ctgaagcgga 180
cccgacagcc gctgcggtga tggactgatc gcgatccacc cggcattgag ccgggctatc 240
cgcgggaagt tcgccggtcc cccgcccaca tacagcggag gatagggctt tgtcaccggc 300
ttcggccagc agtagatcgg atcgaagtcc acatatgtcc catggaattc cgcctgctcc 360
tgcgttcaga tctcgattat cgcgcgcaac cgctcatcga tcacacgtcc gcgcaccgca 420
gggtccacac catggttggc gacttcttcg cgcaaccagc cacacccacg ccgaaacgaa 480
accgtccctg cg 492




588


313


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






588
caggcatgca agcttggcca actcctcatc ggacttgaag gtgccgtcct cgttggcggc 60
cctgctccac ggcacgttga tggcaccagg aatgtgtccg ggccgctggc tttgttcctg 120
cggcaggtgc gcgggggcca ggatcttgcc ggagaactcg tcgggagagc gcacgtcgat 180
gaggttcttg acgttgatgg ccgccaggac ctcgtcgcgg aatgcccgaa tcgtgttatc 240
cggcggggan gcggtgtagg aagtcaccgg ccggctgacc gggtcgctgg acagcgggcg 300
tccgtcgagc tcc 313




589


305


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






589
atactcaagc ttcaaaacag gcctgttgtg ggcgcacccg gctcgccgag ttctgcacgc 60
accgcctcaa gtgcggcccg caccgccggc atctcccggt cacgcagggc cgcggcccgc 120
gccgcagcga cggcgtgttc gcgcagttcg ccgtcaatga tgctgacctg atcggccacc 180
cgggcggtct cggcgtcgtc ccgttcacta atcgcggtgc tcagcagcgt ctcgacagcc 240
accacccgag tggagaccag atgcnccacc acggaccgca gcgatgccag tcacctcacc 300
cgtcc 305




590


394


DNA


Mycobacterium tuberculosis



590
caggcatgca agctttgcag ttgctgagta atgtcggcca acgtcaccac aatcgcgatg 60
aattcaatca tgccgcccag ggcggccaac ccaatggtgg ccgcgagcgg cagctcgatc 120
gcagcgcgga ggttgccggc cgccagttga ttcacgaaca gggtgaggtc ataggcgggc 180
aggatagtga cgaaggcaag acctagatct gccgtcggaa gaagaatcga gtatccggtc 240
gacacaacgg aagcgaaagt gtccgcgatg ttgatgagcg tcgccggttg tggcggcggt 300
ggcggcggta gcaccgtccg cacataccgc gggaacgcgg gcatccgaat ttggggcagg 360
gtgttcaagg cggctggcaa ctcaccatga atct 394




591


457


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






591
ccggctcgta tgttgtgtgg aattgtgacc ggataacaat ttcacacagg aaacagctat 60
gaccatgatt acgccaagct atttaggtga cactatagaa tactcaagct tggccgcagg 120
gccgagtcga ttggtcgcgg tcgcctcgac agttagctta tgcaatgcta acttcggggc 180
aaagttcagg cggatcggcc gatggcgggc gtaggtgaag gagacagcgg aggcgtggag 240
cgtgatgaca ttggcatggt ggccgcttcc cccgtcgcgt ctcgggtaaa tggcaaggta 300
gacgctgacg tcgtcggtcg atttgccacc tgctgccgtg ccctgggcat cgcggtttac 360
cagcgtaaac gtccgccgga cctggctgcc gcccggtctg gtttcgccgc gctgacccgc 420
gtcgcccatg acagtgcgac cctgnaccgg gctggcc 457




592


438


DNA


Mycobacterium tuberculosis



592
gtgtgctgtc aattcagagc tgagcctgat gcactcaact tactgagcat gctaacgctg 60
gtcgtgcggg tcttgttccc gcgtgtcggc agggcacacg ctcggggcgt agctgggaga 120
ggccccggtc aagcccggag agcagtgctc agtccgccag cttgaccgac tttcgatgag 180
aacgcgcttc tcgccgtatt gaactggcgt gctgacggtc gctgagcagc gctcgccgag 240
tgcggccgct gattctttca tcgagccagg aggcgcattc gtgttcggcc gcctgcgggt 300
cggccccatc gtcgacgcga tccgtcaccc actcctcgat caggtctgcc tcatcgaacg 360
ggccaacggt gctgtcggag taagtgtgcg tgggcacgcg agccgggtgc tgtggtacac 420
ccaccgttgc atgaacaa 438




593


220


DNA


Mycobacterium tuberculosis



593
atactcaagc ttcaccaggc gccggcgggc cgcggcgcca agccaggcag ccgcgctcgg 60
cgcgtcgggg ccttccgccg gctcggccga cagttcgatc tctggatcgg cggggctctc 120
cgggccggcc tcggcgacct cagcgggccg cgccttccgg ccgaaccatt ccctagccat 180
agataaccgc acctcaatgc acggtttggc ggcaacccgg 220




594


266


DNA


Mycobacterium tuberculosis



594
agcttccgtc acgacccgcc ctcgccggtg ccggcgccat cggtcatcgg atctcatgac 60
gacgtcacgt aggcccgcta gccgcgagcg ggcgcggtca actggcgagg cggcggcgac 120
gtgactgagc tggccgagct ggaccggttc accgcggaac taccgttctc gctcgacgac 180
tttcagcagc gggcttgcag cgcgctggaa cgcggccacg gtgttgctgg tgtgcgcgcc 240
gaccggcgct ggcaagacgg tggtcg 266




595


105


DNA


Mycobacterium tuberculosis



595
atactcaagc ttgccgggac cgcggaacag aaccggcggt tcctaccgcg gtgtgcggcc 60
ggcgcgatat cggcctcccg actaaccgaa cccgatgtgg gctcc 105




596


141


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






596
acgttggctc tgccggaacg tatttccagc ggcacgcatt cggcgtgggt gccgggcgcc 60
gagttgcgtc gctgggatca cgcagcagtc gccggcggct gccgtcgggc tatgaattgc 120
accgagccgg aaaatccnca c 141




597


234


DNA


Mycobacterium tuberculosis



597
atactcaagc ttgtcgtatt ccgtggcact gtcagacata tgcgccgctc ctcctcatcg 60
ctgcgctcgg catcgtcgcc ggcggtcatg gcgtcaccct acccaagccg aacgcgaaac 120
gagaacgtgt tccattatta gggtgtgagc accaatacca gattgctcac caggaactca 180
cgcagcaccg ggacggatgt cagccaccac ccccatctgg ggtggtagcg ggga 234




598


184


DNA


Mycobacterium tuberculosis



598
cgttggtagc ccgatatgca tagtgtatct tactgaacat gatttccatt atggagcccg 60
gggtgccggc agcgcgaacg gtgcgccgtc agacgcgggc ggcactgacc agggtgttgc 120
gggcgaacat cggcccggct tcggattccg gtccgggtac cgggcgaccc accgcttcga 180
ggta 184




599


351


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






599
atactcaagc ttggccaact cctcatcgga cttgaaggtg ccgtcctcgt tggcggccct 60
gctccacggc acgttgatgg caccaggaat gtgtccgggc cgctggcttt gttcctgcgg 120
caggtgcgcg ggggccatga tcttgccgga aaactcgtcg ggagagcgca cgtcgatgag 180
gttcttgacg ttgatggccg ccaggacctc gtcgcggaat gcccgaatcg tgttatccgg 240
cggggaggcg gtgtatgagg tcaccggccg gctgaccggg tcgctggaca gcgggcgtcc 300
gtccagctcc cacttcttgc gggcgccgtc caacnacttg acttctcctg g 351




600


438


DNA


Mycobacterium tuberculosis



600
atatcttaag cgtcgggtcc cgaggctcgg tcggcagctc cagcaaaacc cgctccaccc 60
ctagatgccg gtatccctca aggtctttag ccgccgcttc accccactgg cacacggtca 120
ccggcacgtc gcccccggcc atggcgcgca accgctgaag cggacccgac agccgctgcg 180
gtgatggact gatcgcgatc cacccggcat tgagccgggc tatccgcggg aagttcgccg 240
gtcccccgcc cacatacagc ggaggatagg gctttgtcac cggcttcggc cagcagtaga 300
tcggatcgaa gtccacatat gtcccatgga attccgcctg ctcctgcgtc cagatctcga 360
ttatcgcgcg caaccgctca tcgatcacac gtccgcgcac cgcagggtcc acaccatggt 420
tggcgacttc ttcgcgca 438




601


410


DNA


Mycobacterium tuberculosis



601
atactcaagc ttgtcgcggt aaacccgcag cagggcggtg ggtgcggtgt caaaaacaac 60
cacacttctt tgcggttcgg tgatctcgac accggccgcg agccgaccac catgcgcgcg 120
taaatcggcg atcagcgcgt cggctatcgc ctgggtgccg cccaccggaa tcggccagcc 180
gaccgaatgg gccagcgttg ccagcatcag tccggcgccg gccgacacca gtgacggcaa 240
cggtgaaatc gcgtgggcgg caacgccggt gaacaacgcg cgggcatcct cgcccgccag 300
cgaccgccag gcaggggtgc cctgggccag catccgcagc ccgagacgca ggaccgagcc 360
cagtgcagta ggcaaagacc gcttgtcgga gacatgaact ccacgaccgt 410




602


456


DNA


Mycobacterium tuberculosis



602
agcttattga accgcgggtc gcaggcaaag tggacctcat aacgactcgg gtccagcgac 60
cgcgccaaca cgaacggccg gacgacgtgg gccagggtcg cggcctcccc tacaaacagg 120
atccgttgcc tgcgagcgac aggctccggt gcggcgttgg gcgccgtgct cgtcccagcg 180
tccggtcccg ggtcgccggc gacgcttgtt tcctccatac tcgcccccta atctcgaggc 240
agcccgtacc cgcaggcaac ctcccaaaaa tgcaatcccc caaaatgcaa tgcgtcgagc 300
tatttctcac accgaccgct agttgcggat cagaaatccg ttgggcgcgg aagtccagcc 360
gaatttgttc tcccgctccg catcatgctt gtaatcgttt ggaaattcat cctcatatgc 420
ctcgatcgct tcatagggtc caggccaaac cgggca 456




603


217


DNA


Mycobacterium tuberculosis



603
cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac aggaaacagc 60
tatgaccatg attacgccaa gctatttagg tgacactata gaatactcaa gcttggccac 120
ctcgcggtgt gtggtggaac ccatctgagc agtgtgccaa accggggcag acagctccca 180
attgacgtga gcccgctcac ttgctgggta agcgtcg 217




604


478


DNA


Mycobacterium tuberculosis



604
tagcgccccc tcccgggcgg agctccacgg cgtggatcaa ggtaccggcc gggatgttgc 60
gcaatggcag gttgttgccc ggcttgatgt cggcgttagc gccggattcc accacatccc 120
cttgcgaaag tccgttgggt gcaatgatgt agcgcttctc cccatcgaga tagtggagca 180
acgcaatccg tgcggtacgg ttcgggtcgt actcgatgtg cgcgaccttg gcgttgacac 240
catctttgtc attgcggcga aagtcgatca tccggtaagc gcgcttatga ccgccgcctt 300
tgtgccgggt ggtaatccgg ccatgcgcgt tgcgtccacc gcgaccgtgc agcgggcgca 360
ccagcgactt ctccggggtt gaccgggtga tctcggcgaa atcagatacg ctggcgccgc 420
gacgaccaag cgtcgtgggc ttgttcttgc gaattgcatg tctaatcagg tctttctc 478




605


459


DNA


Mycobacterium tuberculosis



605
tgaaactata taatactcaa gcttgccaaa gaagacctcg tcgaccaagc aggacgcgac 60
cgtcgaggtg gcgatccggc ttggcgtcga cccgcgtaag gcaaaccaga tggttcgcgg 120
cacggtcaac ctgccacacg gcactggtaa gactgcccgc gtcgcggtat tcgcggttgg 180
tgaaaaggcc gatgctgccg ttgccgcggg ggcggatgtt gtcgggagtg acgatctgat 240
cgaaaggatt cagggcggct ggctggaatt cgatgccgcg atcgcgacac cggatcagat 300
ggccaaagtc ggtcgcatcg ctcgggtgct gggtccgcgc ggcctgatgc ccaacccgaa 360
aaccggcacc gtcaccgccg acgtcgccaa ggccgtcgcg gacatcaagg gcggcaagat 420
caacttccgg gttgacaagc aggccaacct gcacttctc 459




606


464


DNA


Mycobacterium tuberculosis



606
gctgagctcc acggcgtgga tcaaggtacc ggccgggatg ttgcgcaatg gcaggttgtt 60
gcccggcttg atgtcggcgt tagcgccgga ttccaccaca tccccttgcg aaagtccgtt 120
gggtgcaatg atgtagcgct tctccccatc gagatagtgg agcaacgcaa tccgtgcggt 180
acggttcggg tcgtactcga tgtgcgcgac cttggcgttg acaccatctt tgtcattgcg 240
gcgaaagtcg atcatccggt aagcgcgctt atgaccgccg cctttgtgcc gggtggtaat 300
ccggccatgc gcgttgcgtc caccgcgacc gtgcagcggg cgcaccagcg acttctccgg 360
ggttgaccgg gtgatctcgg cgaaatcaga tacgctggcg ccgcgacgac caggcgtcgt 420
gggcttgtac ttgcgaattg ccatgtctaa tcaggtcttt ctct 464




607


205


DNA


Mycobacterium tuberculosis



607
atactcaagc ttgttggtga cctcgccggc gaacagttct cgcacgattt ccggattagc 60
gggactggtc accagttggg tatgcgggaa ggcgctgacg ttcgccgcga ttagctgttt 120
gatggacgcg gcggtgatgt cctgatcacg gaactggctg taatagccca gggtcgccac 180
gcttccatcc gggcccggac ccggc 205




608


244


DNA


Mycobacterium tuberculosis



608
gatgatcgcc ggtgccaccc cgatccgtgc ctcggtcagc gcgaacgtgc tttccggtcc 60
ggcgaccacc atgtcgcacg caccgaccag gccgaacccg ccggcccgca catgcccgtt 120
gatggcgccg accaccggca gcggcgactc gacgatggcg cgcaacagcg ccgtcatttc 180
ccgcgcccgc gccaccgcca tccggtacgg atcaccacca cctccgccgg cctcgctgag 240
gtcc 244




609


289


DNA


Mycobacterium tuberculosis



609
atactcaagc ttgccgcaat cgaaaccaac ctgtttgtgc cgcaagaaat tacgccgtgg 60
cccggcgccg atcaagaaac gccccggcgc gcggcggtgt cgtcgtatgg catgacgggc 120
accaatgtgc acgccattgt cgagcaggca ccggtgccag cccccgaatc cggtgcacca 180
ggcgacaccc cggccacacc cggtatcgac ggcgcgctgc tgttcgcgct gtcggccagc 240
tcgcaggacg cgctgcggca aaccgccgcg cggctggccg attgggtct 289




610


282


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






610
ttggcgggtt ggccacanca ncccgccggt gacggcgacg atgctgggct ggttgcggcc 60
ctgcgccacc gcggcttgca tgctggttgg ctgtcttggg acgatcccga aatagtccac 120
gcggatctgg tgattttgcg ggctacccgc gattaccccg cgcggctcga cgagtttttg 180
gcctggacta cccgcgtggc caatctgctg aactcgcggc cggtggtggc ctggaatgtc 240
cancgccgtt cacctacgtg accttgatgg gatccggggg nt 282




611


312


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






611
ncgtggacac cggtgtcgan cgccaccagc cgcatgtctg cangtcnatt ccgtcctcgg 60
caacatcttg aatgccgagc agcgcctggg cgtgatcggc aaccggggat gaccgctcgc 120
cgatccgctc gacaatcccg gcggcacgtg acatgccggc ggacggctcg acgagctgga 180
acttcagcga cgacgatccg gaattgatca ccagcacggt gctactcatg gacccctgcg 240
cctgaatccc gtgatggcca cggtgttgac tattcgtcga cagtgcaccc gagatagtct 300
tcacggctgc gt 312




612


349


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






612
catgtattgc cgtgctcacg gcgccacgct cgatggtttc tcgaagtctc cgggctggtg 60
tacagcttct cgttgatctc gttcgccacg ccgtcctctt cccgccgacg acccgatctc 120
gatctccana atgatcttgg cggccgccgc cgccttgagc agctcctggg cgatggccag 180
gttctcatcg atgggcactg ccgaccgtcc cacatgtgcg acggaacaaa gatgtcacct 240
tgctcacgcg tgcgcnagat cncanaaggg ccggacatac tgtcnacttg tccttgggca 300
gtggtccgtg tcagcccacg tgacgggtac ttggcgcgat aacgtggtg 349




613


350


DNA


Mycobacterium tuberculosis



613
gccaccacga cccggccgta actctgctca cggaaatgcg gccaggccgc gcgtagcacg 60
tggtatccgc cataaaggtg caccttaagc acggcgtccc aattctcgaa cgacatcttg 120
tggaaggtgc cgtcgcgcaa gatcccggcg ttgctcacca caccgtgcac ggcgccgaat 180
tcgtcaagcg cggtcttgat gatgttcgct gcgccgtcct cggtggcgac gctgtcctta 240
gttggcgacc gcccggcccc ccttgtcgcg aatctcggcg acgacctcat cggccatcgc 300
cgaacggcgc ccgtgcccgt cgcgggcgcc accgaggtcg ttgaccacga 350




614


126


DNA


Mycobacterium tuberculosis



614
caggcatgca acctttgtcc acacggcgtc tactccgtgc aaggtccgac cgcttccacg 60
tcccgccgtg acggtgctcc atctccctca gcaacgcgtg aagtggtccg atcccgcggc 120
ttcagg 126




615


395


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






615
gttgagacgc aaccagcgca caacgacgat ttggcgtagc ggcggacgtc tgctcgattc 60
gatcacgtcg cgctcgcatc gagcatggcc cgcgacgcta cacgatcgcc gtcgtcgatg 120
acacgaccga gccgtacgcc ggccgtaagc cgcgccagga ttcggcgaaa aacgtctacg 180
tggcgggtgt actgggtgtc gaatgattcg tggggtgcgt atgcgtcctg caatcgtcga 240
catagatccg tcgccgcatc gcgtcgacaa ctccgggtga gtggaataca cttgccgatc 300
acgcgacgtg cgcggatcga tgccgaccga aatacgacca catggctctt gttgcncagt 360
gttggcggca tcaaataccc tcagtgccgt ccgac 395




616


371


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






616
ttnccgcctt nacgcctact ccnagacgat gctcgacgcg tgtgagcaca cggcgctgct 60
gtagacggca cggcgcagct ggatcgcgct tggtgcaccc aagcctctac gcgcgtcgct 120
gcgtcgtcat cgggtaccga acatattccg gtcgttgcgc agagtgtgca tgtgcggctc 180
ttgtgaacga acatagcaaa gcgtatatgt ctgtggcggc tctgcagata tcgcgataat 240
acgtatatac ataaggtggc gcgcgatcta tcggtatatc cgttatggcg gacgtgcgtg 300
agcgtgagtc gcggcgcatc gcgcacttcg cgatcgcgtg actggtcctc gcgactgcgc 360
gcatgcgtag c 371




617


423


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






617
ggtgatgacg cacttgcttc gaatgagtca ttgactactc ccgtggttgt cctgcgatgg 60
tggagtgccg cgcagccttg cccgangtcg cgatcgcgtc gcgggcttcg gggagcagac 120
tgacctgcag atggaagtcg tgccacatgc ccgcgaacgg cgagctcgat gcttgttttc 180
gaagngcgca ngcggtttcg atcttgtccg cgtcaacgca gatcggatct cgccgcggtc 240
tgcatgacga tgggcgcagg cccgctcatg tcccgtagac ggggagatac gggcagccgc 300
ggatcgagac ctacgtagcg cggcgcccat cgtgccatcg acgaagaatg acggatcgcg 360
cagcgccgtc gcgtcgcttc gatgtcacgc gagatcgcca cggcagatca gcgatgcgcg 420
ggc 423




618


354


DNA


Mycobacterium tuberculosis



618
cggtacgccg gcaacaaacg ccttgtgacg agcgcgtccg agcggtcatc ggcctccacc 60
gtcatgcaca gctccttctc caggtctacg ccgacgtcgc ggtccacatt ggtgagcttg 120
gcgaatgcct cggcaacctc gtcgaaatgc gcctccgcgt ccgcatcgaa ggtcgccatg 180
tcaaagatca actcgacgta gtagctagtt accgcatcag gtcagtgttt gctggcctcg 240
gagtccggcc gaacaatggc catttcccgc gactctagaa tccagtcatc gtctcggtga 300
cgacgccttg ccgatcacat agctcgaccg gatcggagag aatctggttc tcgt 354




619


128


DNA


Mycobacterium tuberculosis



619
atactcaagc ttaagcgcag cagtaccggc ggtgcctggg catcccagca aaacggggag 60
ctcaacgaac gattcctgaa cgaagggtcg tccaccaacc tccaaaccga acggttgcca 120
gccccggc 128




620


295


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






620
gcaagtccgc tcaatgtggt tgtgatcaca ngactacgtc gcctcaatca gctcaaacgt 60
caccccgtgg cgtgctgcgc agcatgaagg tcggcgcccg cacgatgtgg gcgaagcaac 120
aggtaataac tggtcggcat gggtcaaccc tcattgggcc gttgcggatc gggtgcacgc 180
ccggagtgcc ggtcgaactc aacaccgcct tcaccgatct tttcgtcgaa aatggcggtc 240
gtgtcggggt atacgtccgc gatcccacga ggcggaatcc gctgagccgc actga 295




621


361


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






621
atactcaagc ttcgcgccct caagcggctg aaggtggttc cggcgtncca acngtcgggc 60
aactcgccga tgggcatggt gctcgacncc gtcccggtga tcccgccgga gctgcgcccg 120
atggtgcagc tcgacggcgg ccggttcgcc ncgtccgact tgaacgacct gtaccgcagg 180
gtgatcaacc gcnacnncnn gntgaaaagg ctgatcgatc tgggtgcgcc ggaaatcatc 240
gtcaacaacn agaancggat gctgcnggaa tccgtggacg cgctgttcga caatggccgc 300
cgcggccggc ccgtcaccgg gccgggcaac cgtccgctca agtcgctttc cgatctgctc 360
a 361




622


361


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






622
tgcgcatggc agttgttgcc ggcttgagtc gcgttagcgc ggattccacc acatcccttg 60
cgaagtcgtg ggtgcaatga tgtagcgctt ctcccatcga gatagtggag caacgcaatc 120
cgtgcgtacg ttgggtcgta ctcgagtgcg cancttggcg ttgacaccat ctttgtcatt 180
gcggcgaagt cgatcatccg gtaagcgcgc ttatcgacgc cgcctctgtg ccgggtggta 240
atccggccat gcgcttgcgt ccaccgcgac gtgcagcggg cgcacaccga cttctccggg 300
tgacgggtga tctcggcgaa tcagaacctg gcgcgcgaca cagcgtcgtg gctgtacttg 360
c 361




623


312


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






623
tgggtgatca gatactggct agttggtcgg gtggggtgat cgaagatcgc ggtggccggc 60
agcgttactg cggtgacgct gttaagcggt tacgtactcc acggcactca angaattana 120
tcccgaatcg gcaaaccctg gccagcgtcg agtccgcagc gccgtcgcgc cccccaccgc 180
tgcggcatgc tcacatacca cctcgatcgc tgcgggagtt gctcgtcggc cgaccgaccg 240
gccagccggg cggcaaaccg gaggacccaa gattcagcac caccatcgct agcccgatct 300
ggccgcgcgt gg 312




624


454


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






624
tcgtagcggt tgcgaccant ccgcggacag ctccgccacg cgacgggtcg ggatcaccgc 60
ggtcaaacca ccgagcggcg aggatctctg gccgtcgacg tgaccgcgca cggccgcggt 120
gatggccagt cccgaccgcc gttccacttg gcgtacgcgc tggatgtgtt gtgccgcaac 180
ggaatcccac ctcaattatg acctcgttgt gggcgagcgc ggtatcgtac gcccgaccag 240
gaatcgtcga tgctatctca cgtcaccgaa ggcctctccc agcacaccgc atccagaacg 300
tgcacacngt cgacatgtct cggcggatcc gcctgcagaa cgaacgccan gtgcgctgtg 360
cgacacgggt cgcgatcacc gctcgcacgc ggagatcggc acacgcgcag cgcatcgatc 420
ataatctctc gatgcggtct ccaccaccga acag 454




625


366


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






625
atactcaagc ttcgctgagg tggtggggca cgatcacgtc accgcaccgc tgtcggtggc 60
gctggatgcc ggccggatca accacgcgta cctgttctct gggccgcgtg gctgcggaaa 120
gacgtcgtca gcgcgtatcc tggcncggtc gttgaactgt gcgcagggcc ctaccgccaa 180
cccgtgcggg gtctgcgaat cctgcgtttc gttggcgccc aacgcccccg gcagcatcga 240
cgtggtagag ctggatgccg ccagccacgg cggcgtggac gacacccgcg agctgcggga 300
ccgcgcgttc tatgcgccgg tccactcacg gtaccgggta tttatcgtcg acgaggcgca 360
catggt 366




626


363


DNA


Mycobacterium tuberculosis



626
gcactcacgc tggtacaaga ccttcacaaa atctgaaatc ctgacccgat acttgaacct 60
ggtctcgttc ggcaataact cgttcggcgt gcaggacgcg gcgcaaacgt acttcggcat 120
caacgcgtcc gacctgaatt ggcagcaagc ggcgctgctg gccggcatgg tgcaatcgac 180
cagcacgctc aacccgtaca ccaaccccga cggcgcgctg gcccggcgga acgtggtcct 240
cgacaccatg atcgagaacc ttcccgggga ggcggaggcg ttgcgtgccg ccaaggccga 300
tccgctgggg gtactgccgc agcccaatga gttgccgcgc ggctgcatcg cggccggcga 360
ccg 363




627


367


DNA


Mycobacterium tuberculosis



627
atactcaagc ttgtataaaa agatcggtga gcgcatcgat tcgctccgcc gggtttgccg 60
ctgcggcggc ggagctgccg tgaccgtcta tttgggtgat cagatactgg gctagttcgg 120
tcggggtggg gtgatcgaag atcgcggtgg ccggcagcgt tactgcggtg acggctgtta 180
agcggttacg tacctccacg gcactcaagg aattaaatcc cgaatcggca aacgcctggc 240
cagcgtcgaa tccggcagcg ccgtcgcgcc ccagcaccgc tgcggcatgc tcacatacca 300
cctccatcgc tgcggcgaat tgctcgtcgg ccgaccgacc ggccagccgg gcggcaaacc 360
cggaaga 367




628


518


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






628
cctcatcata tgccgataga gctctacata ttcaggagat caccatggct cgtgcggtcg 60
ggatcgactc gggaccacca actccgtcgt ctcggttctg gaangtggcg accnggtcgt 120
cgtcgccaac tccggagggc tccaggacca cccgtcaatt gtcgcgttcg cccgcaacgg 180
tgaggtgctg gtcngccagc ccgccaagaa caggcagtga ccaacgtcga tcgcaccgtg 240
cgctcggtca agcgaccatg ggcagcgact ggtccataga gattgacgca agaaatacac 300
gcccggagat ctcgccgcat tctgatgaac tgaacgcgac ccgaggctac tcggtganga 360
catnacgacg cgttatcaca ccccgcctnc ttcaatgacc ccacgtcngg caccaaggac 420
ccggcaatcg cggctcactt gngcgatngt cnacaaccaa cgcgncgcct ggctacgggc 480
tcaacaaggc anaagacaca atccgctctc gattggtg 518




629


435


DNA


Mycobacterium tuberculosis



629
atactcaagc ttatcgaggc ggcgcatacc gaagcgtggg aaatccagac cgaataccgc 60
gacgtgctgg acactttggc cggcgagctg ctggaaaagg agaccctgca ccgacccgag 120
ctggaaagca tcttcgctga cgtcgaaaag cggccgcggc tcaccatgtt cgacaacttc 180
ggtggccgga tcccgtcgga caaaccgccc atcaagacac ccggcgagct cgcgatcgaa 240
cgcggcgaac cttggcccca gccggtcccc gagccggcgt tcaaggcggc gattgcgcat 300
gctacccaag ccgctgaggc cgcccggtcc gacccggcca aaccgggcac ggcgccaacg 360
gttcgcccgc cggcaccacc ggtccggtga ccgcagtacg gtccccccag cctgactacc 420
gtgccccggc gggct 435




630


398


DNA


Mycobacterium tuberculosis



630
tggccgggct ggtagcccgc gtatggcaag gttccgctca atgtggttgt gatgcagcag 60
gactacgttc gcctcaatca gctcaaacgt cacccccgtg gcgtgctgcg cagcatgaag 120
gtcggcgccc gcacgatgtg ggcgaaggca acaggtaaga acctggtcgg catgggtcga 180
gccctcattg ggccgttgcg gatcgggttg cagcgcgccg gagtgccggt cgaactcaac 240
accgccttca ccgatctttt cgtcgaaaat ggcgtcgtgt ccggggtata cgtccgcgat 300
tcccacgagg cggaatccgc tgagccgcag ctgatccggg ctcgccgcgg cgtgatcctg 360
gcctgtggtg gtttcgagca taacgagcag atgcgaat 398




631


464


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






631
gtccagtcaa gcatcggtcc tctccgacta cgccaagant ggcgacgtgt cagtgcanac 60
agcgganatg gtggcgccta tgcgtcgacg ctcacaaacn gcggtgancg cgttctggtc 120
gtgcaccatc gagccgtgcc agcccggccg cgtgccgtca gccgcatcca ctggatgcct 180
tctcggngtt tcaatcangt acangcgacg ttcgccacca tcgtgccggg gcacggttag 240
cgagaaaccg ccgacttcac cgattgcctc ggtgatgccg tcgaacagat cgggcctatt 300
gtcgacagcc agtgtgatnc gtatttgccg ccgtgctcct cgtcgcaacg atgcgaacac 360
agatccgtgg nggacgatag cggctgacaa ngtgggggca acacaatcac atgccacatt 420
tcttcatttc acgcccacaa cccagacttc gtctcgatgn gccg 464




632


499


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






632
cacgcggtct ggcccgatcc gaagatccct ttgccggcgt ggcggctctg ctcggcggtg 60
ttgtacactt ctcgaacacc tcggcaccga caccaccacc gtngcttgaa caccgccaac 120
atcggcagca gatcttgatg gtcctggtga atcccacggt gactttggag tggaaggcgc 180
catactgatc gccgcgccag cacatgagct agcggcagga aaaccagcag ccgctcacct 240
tgcgcagcag cgtcnggtga tatgcctggc gcccttaatc tcgtgaacca gttggattgg 300
gtcaactggc agccttgggt ctccggtggt gccgangtgt anataagctc ccgggtccgt 360
caacgtantg cgcaggcggc ggttactcgg cgggtcaacg agccccgctc gtgagcnatc 420
agcctttgga ccgaacggga ttcatactcc gcaggcggcc ctccgaaatc ggcacatgtc 480
ctttgatcgt tcgcaacan 499




633


343


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






633
ggccatgtca catcggtggt acaggtaaac cgcgccgtgt gcgcggtctc ggagatcaga 60
acgtggtcgc agttgaaccg cgggctttca gccagtcgcg ataatcggcg gaagtcggcg 120
cctgccgccc caactagcgc gactcgccac ctagcacacc gatggcgaag gccatgtntc 180
cggccacgcc gccgcggtgc atcaccaagt catcgactag gaagctaagc gacancttgt 240
gcaggtgttc gggcagtagc tgctcggaaa atcggctgga aaccgcatca aatggtcggt 300
ccaatcgaac cggttacccg atcgtcacaa aaatctccgt cct 343




634


192


DNA


Mycobacterium tuberculosis



634
gggtctacaa ccaccgggtc tgacttctgg gcttccaccg ctcgcgccgt cgcgacaaac 60
agcgcggtcg aaccgacact cgttgtgatg tcccagctat cacctccggt aggcacccaa 120
tcgaccctac ccggctatct cacccccgat ctccaggctc cgccgatcca tgcgcatccc 180
ggtccggatc cc 192




635


376


DNA


Mycobacterium tuberculosis



635
caggcatgca agcttgtcgt attccgtggc actgtcagac atatgcgccg ctcctcctca 60
tcgctgcgct cggcatcgtc gccggcggtc atggcgtcac cctacccaag ccgaacgcga 120
aacgagaacg tgttccatta ttagggtgtg agcaccaata ccagattgct caccaggaac 180
tcacgcagca ccgggacgga tgtcagccac cacgcccatc tggggtggta gcggggaaat 240
acggctaacg cggctccggt gccggcagcc cagcgcagac cctcggcggc ggacacggct 300
aacaacgacg acccatagtt gttctttgcc ggatggccgt gtttgctgac atatcgggcg 360
cggcgccggc gccgcc 376




636


83


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






636
nctacgctgc tgaatgttgt gcgccggagg anctcaagac ccacgcggtt gtacgcggac 60
ntgcgacatg ttcaaccgcc gga 83




637


319


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






637
ctaaccaaca agccatggtg gttggcgccg tcgagaggtc ggcggtcgcc acaacgggaa 60
gatcgccttg agcgtcgctc gaccgccgcc tcgagttggg tcataacgaa gtactgatgc 120
cgatcatgtc gacgtgtccg tcgcatcagc gtgcagcggc gacccctcga cgagcctcgg 180
tgccgccgcg gccagggcac cagctgtttt agcgcattgt gctccgccgg taataaagga 240
ngtcggtcgc ctccgctgct gtggttgcgg aataacatct tcccttcctg caacaggatg 300
agaatggttt taattgctc 319




638


94


DNA


Mycobacterium tuberculosis



638
ctaagctttc gggtccgccg ccactagtac cgcgttgccg gccccgccga cctagaatgt 60
tccgcccatt gccgtttcct cccgccgccg ggtt 94




639


122


DNA


Mycobacterium tuberculosis



639
tctggtgccg ggtgtgccga cgggtccgtc cgcctctgct tcagtgattc tgtgatgcga 60
ccggcaacgt cctcgttgtt cggtgtctat gtggtccgtc tctccttgtt ccgcatacga 120
tt 122




640


210


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






640
gcgatcgntn accacaaggg cgcaaccgtt cgcgcgtcga ctgaacgtgc tgccgcctgg 60
agaactggcg ctgctgccac ctggtcggcg catcggcact tcgaggactg gatttcgacg 120
cgtggcccga cctgangtng gcggtggacn ngtgtgcacc cggttgattc ctcggccttg 180
ccgggatgcc acctgcgcct ggtggtcgat 210




641


328


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






641
cgtgaccgga cggggtgccg cgcgaaccgg tcttggccaa ttgccgggga ctggggctgg 60
agtataaagc gggcctgttg ccggaagata aagtcaaagc ggtgaccgag ctgaatcaac 120
atgcgccgct ggcgatggtc ggtgacggta ttaacgaccg ccagcgatga aagctgccgc 180
catcgggatt gcaatgggta gcggcacaga ctggcgctgg aaaccgccga cgcacattaa 240
ccataaccac ctgcgcggct ggtgcaaatg attgaactgg cacgnccact cacgccaata 300
tccgccagaa catcactatt gcgctggg 328




642


553


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






642
atactcaagc ttcttaccca nagcatgaac cccgccgtcc aatgccgcca ccgtggtgct 60
gtcggccggc cgggtgcggg cacaatcgcc gagttcggcg aacagatcct cgaaggtctt 120
cacggccagc gattgttgca cgtgtcagcc agccaagtca cggtggtttg acgccacacg 180
ttcgccaccg ccgcgccgcg cattagggca tcctaatata ggttaggcta ccctanttat 240
tcctgtggtc naaggaggca gccgaacgtg accttcccga tgtggttcgc agttccgccg 300
gaagtgccgt cagcatggct gtccaccggc atgggccccg gtccgctgct ggccgcggcc 360
agggcgtggc acgcgctggc cgcgcaatac accgaaattg caacggaact cgcaagcgtg 420
ctcgctgcgg tgcaggcaac tcgtggcagg ggcccagcgc cgacggttcg tcntccccat 480
caaccgttcc gtattggcta accacctgca cggtggcacc gcacaacgcc gccacaaacg 540
cgccccggta tac 553




643


486


DNA


Mycobacterium tuberculosis



643
ggccgaactt aatcggttgt tggcggctgc cgagttgggt cactcggggg gtgtgcactg 60
gcacatggtg ggccggattc aacgcaacaa agccgggtcg ctggctcgct gggcgcacac 120
cgctcactcg gtggacagct cgcggttggt gaccgcgctg gatcgggcgg ttgttgcggc 180
gctggccgaa caccgtcgtg gcgagcggct gcgggtttac gtccaggtca gcctcgacgg 240
tgacggatcc cggggcggcg tcgacagcac gacgcccggc gccgtagacc ggatttgcgc 300
gcaggtgcag gagtcagagg gcctcgaact ggtcgggttg atgggcattc cgccgctgga 360
ttgggacccg acgaagcctt tgaccggctg caatcggagc acaaccgggt gcgtgcgatg 420
ttcccgcacg cgatcggtct gtcgcgggca tgtccaacaa cttgaaatcc cgtcaacatg 480
gtcgac 486




644


146


DNA


Mycobacterium tuberculosis



644
gcttcccctg atactcgacc agccccactc gggccaatac gtgaatgtcc tagcattttt 60
cacccgttca cgggctagtc gagtagtaga cgattgatta gcctgaacgt acctccgacg 120
gccagctgac gaacgggttt gacgga 146




645


204


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






645
tcagctgtct gtagaagggc tggcgatact gtgcactgtc tgatatcgcn ncgtngtggg 60
actatncagn ccatnangat gcggttcngn nnntgcagag natcctggna cacatncggt 120
tcacgttaat cancatcgcg anttnctncg tnttcgatta nttctgctaa cgnntctnnn 180
agtgcctgcg ggtcgactct agag 204




646


209


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






646
nctctgccgg gcnagagcgc agagtcggac ggcttcgtcg atcgtgaagc gaccntgcga 60
tgancagata tcgntnacac tgctcanaaa cttcggatca tcgntgatac acaggccaac 120
gggtagcggt tgtccaaccg cttcgtcaac ganatgggat cgtgacganc ctacgctcgc 180
aggatatgtc gcngaccngn tctaganan 209




647


183


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






647
cacttcatgc tcgtgcgttg gcntcgattt gcncgagngg ttagctcctc gagtgngtga 60
cgtatcactc cggcngacta nccgtatcng cgtcccgcac cggtcaactg gtctagccac 120
accggggaga atncncgacc ggngctatcg accnatcacg gcttgtcgnn aagatagnca 180
gcc 183




648


154


DNA


Mycobacterium tuberculosis



648
atactcaagc ttgccaaccg ccaccctgca tccggggggc gagcactgct ccgccgacca 60
gtacgaacca acctgcggtg cccaggccat tgacaatgtg ctggtcggcg cccgcgagtt 120
ctagcacagc aacgccgcgg ccaccacagg ggcg 154




649


219


DNA


Mycobacterium tuberculosis



649
cggtcggtgt gcttggcggc gtcggtatca acaccgccca cgaaatgggg cacaagaagg 60
attcgctgga gcggtggctg tccaagatca ccctcgccca gacctgctac gggcacttct 120
acatcgagca caaccgtggc catcacgtcc gggtgtccac accggaagac ccggcgtcgg 180
cgcggttcgg caaaactttg tgggatttcc cgccccccc 219




650


307


DNA


Mycobacterium tuberculosis



650
aatactcaag cttcgcggag gtggtggggc aggagcacgt caccgcgccg ctgtcggtgg 60
cgctggatgc cggccggatc aaccacgcgt acctgttctc tgggccgcgt ggctgcggaa 120
agacgtcgtc agcgcgtatc ctggcgcggt cgttgaactg tgcgcagggc cctaccgcca 180
acccgtgcgg ggtctgcgaa tcctgcgttt cgttggcgcc caacgccccc ggcagcatcg 240
acgtggtaga gctggatgcc gccagccacg gcggcgtgga gcaaccccgc gagctgcggg 300
accgccc 307




651


252


DNA


Mycobacterium tuberculosis



651
gatggcactc acgctggaca agaccttcac aaaatctgaa atcctgaccc gatacttgaa 60
cctggtctcg ttcggcaata actcgttcgg cgtgcaggac gcggcgcaaa cgtacttcgg 120
catcaacgcg tccgacctga aattggcagc aaaccggcgc tgctgggccg ggcatggtgc 180
aatccgaaca agcacgctca acccgtacac caaccccgaa gggccgctgg cccggcggaa 240
ccttgtcctc ca 252




652


402


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






652
aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagctt 60
ctgggcgtcg tggtgcccgg cctgccggtg caggaactgg attttactgc catctctcgc 120
gaccctgagg tggtccaggc ttacaacacc gacccactcg tgcaccacgg acgggttccg 180
gccgggattg gccgcgcgct gctgcangtg ggcgagacca tgccgcggcg ancaccggca 240
ttgaccgcgc cgctgctagt gctgcacggc accgatgacc ggctgatccc catcgaaggc 300
agccgtcgcc tggtcnaatg tntnggatcn gccgacgtgc anctgaanga ntatccccgg 360
ctgtnccacn aggtgttcaa cgaaccggan cgcaaccaag tg 402




653


429


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






653
caaggcatac gccaagaccc aagggatcgc agtcacctcc gtcaacggcc tggtcgccgg 60
ccacgggtcc gtgcaggaga cgtggctggc catgcaaagc gccgccgcct tatcaggaac 120
gccccggctt gtcggctttt cctgcatcga cacatttccg gaggtgttgt ggttggcgca 180
ncgcgcgaga caggcctggg atggcgtgcg catcgtcatc gggaatgcga tggcaacact 240
gaactacgag cgcatcctgc gccagcatga ctgtttcgac tacgtcgtcg ttggcgacgg 300
ggangtagcg ttcaccaagc tggccttggc cctggcgaat gacctgcggt tgacgactcc 360
cgggactaac ccgccgtant gagcaaggac agattctgcg cacaccctcc tcgctggtcg 420
accttgaca 429




654


353


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






654
aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagctt 60
gccggtgatc tgggtggcca actcggcggg caccatctcc atcacgacng caaacgctcc 120
ggcttcggcg acagcgatcg cgtctgcgat ngtttgttcg gcggcgtctc cgcggccctg 180
cacccggaag ccgcccaagg tgttgacnct ttgcggggtg aagccgatgt gtgccatcac 240
cgggatnccc gccgcggtca gacangcgat ttgctcggcc acccgctcac cgccctcgan 300
cttgacngca tgtgcgccgc cgtccttgaa gaaaccggtg gcggnggcaa ccc 353




655


464


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






655
cgttgagatc cagctgcgca ctgtgcagcg cctcggtggt ctgctcggcc tgccgggata 60
actcgttgag cttggccagc gcgtcgtcgg ccggatcagc cagcacattc gcggccagga 120
cgccggagga gacggtgaag ctcgcaaaga aacctatggc ggaccgcatg attacacgcg 180
cgatcaacca cctctggtcg agcctcaaaa tttgcttcct taaacgggcc atcgacggat 240
gacgtcgagc tggtttaggt ctcaaacagg ttacgaaacg atctcggaat tgtccaaaag 300
gggaagttaa gaaaatggat agatttctac catttcgctg tggacgatcg tacttctgct 360
atagggctcc aggggcatcg acacgcaacg accttacgcg acaccggatc cgcgctggcg 420
gcggaacggc accangcgca accgaagggc caatccgaca tcgg 464




656


515


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






656
atactcaagc ttatctaggc gccagcttga ttggtctggt tgcattggcc agctgcgcga 60
gcctggctca cttcaactac aacaaccgca aacaattgcc gccttcggat ccgagttcgg 120
ttgggtacgc ggcaatggan caccatttct cggtgaatca gactattcct gagtacttga 180
tcatccactc tgcacacgac ctgcgaaccc cgcgcggcct tgccgacctg gagcagctgg 240
cgcaacgtgt gagccanatc ccaggcgttg ccatggttcg cggtgtgacc cggccaaacg 300
gggaaaccct tgaacaggcc cgggcgacat accaagccgg ccaagttggc aaccggctgg 360
gcggcgcgtc gcgaatgatc gatgagcgca ccggcgacct gaatcggctg gcatcgggtg 420
ccaacctgtt ggccgacaat ctcggtgact tcgcggtcaa gtcagccggg ccgttgcggg 480
tgtccgcagc cttgtccagc ccctcgctta ctcca 515




657


403


DNA


Mycobacterium tuberculosis



657
caggcatgca agctttttga gcgtcgcgcg gggcagcttc gccggcaatt ctactagcga 60
gaagtctggc ccgatacgga tctgaccgaa gtcgctgcgg tgcagcccac cctcattggc 120
gatggcgccg acgatggcgc ctggaccgat cttgtgccgc ttgccgacgg cgacgcggta 180
ggtggtcaag tccggtctac gcttgggcct ttgcggacgg tcccgacgct ggtcgcggtt 240
gcgccgcgaa agcggcgggt cgggtgccat caggaatgcc tcaccgccgc ggcactgcac 300
ggccagtgcc cgcggcgatt cagccatcgg gacatcatgc tcgcttcata ctcctcgacc 360
agtcggcgga acagctcgat tcccggaacg cccacgcatg gtg 403




658


444


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






658
aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagctt 60
gtagaaaaag atcggtgagc gcatcgattc gctccgccgg gtttgccgct gcggcggcgg 120
agctgccgtg accgtctatt tgggtgatca gatactgggc tagttcggtc ggggtggggt 180
gatcgaagat cgcggtggcc ggcagcgtta ctgcggtgac agctgttaag cggttacgta 240
tctccacggc actcaaggaa ttaaatcccg aatcggcaaa cgcctggcca gcgtcnagtc 300
cggcagcgcc gtcncgcccc agcaccgctg cggcatgctc acataccacc tcgatcgctg 360
cggcganttg ctcgtcngcc gaccgaccgg ccanccgggc ggcaaacccn gaagacccaa 420
gaattcatca ccaccatcgc tagc 444




659


437


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






659
ccttcttgac acccacctcg ccatcgacct tgagcactcc gtcgtagttg gtgaacatgt 60
gaccggcgat cgggcgggtg aacgcgtact gggtgtcggt gtcgacgttc atcttcacca 120
cgccgtagcg cagcgcctcc tcgatctccg acttaagcga acccgagccg ccgtggaaca 180
cgaaatcnaa cggcttggcg tcngccggca gtccgagctt ggccgccgcc acctgttgcc 240
cttgcgcaag gatgtcnggg cgaancttga cgttgccggg cttgtanacg ccatgcacgt 300
tgccgaacgt cncggccagc angtatttgc cgtgctcacc ggcgcccanc gcctcgatgg 360
ttttctcgaa gtcctccggg ctggtgtaca gcttctcgtt gatctcgttc gccacgccgt 420
cctcttcgcc gccgacg 437




660


422


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






660
aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagctt 60
ggaaaggaga tccccgggaa cctggtggca accccgccat tggggttgtt gggattgccg 120
atcagcgtga angaaagctc gtctggagac agcgggtcgg ccgaagccgc aagattggcc 180
atcactagtg acganatcgt ggcgctctgc gagtanccna agacagtgac gttgttnccg 240
gcggcaattt gctgccgaat cgcactttcg agaatgacng caccctgcgc caccgangaa 300
tcnaaagtga ggttcttgat cacgaccacc gggtngagcc cttggggcgt gaagancgcc 360
tgcgcnataa cacccgggac gctgccactc atgtncagcg cgttcgcgan ctcnacatat 420
ct 422




661


412


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






661
tcctggtgat cganggccgc ggttccggcc gaaaatccgg ttcgggttcg ggtcgcggtt 60
ccaacttgan cgcggtccgc agctgattca ccgtggcaac gccggccaac tgcgcataat 120
gcgcatccga accctcaccc gcccgccccg cgatcacccc aacctgatcc aacgacaacc 180
gcccctcccg cataccccgg gcgcagcgcg gaaactccgg caaccgccgc gccaccgtgg 240
cgatcgtgtg ggcgttgcct gacgaacanc ccatcttcca ggccaccaac cccgccaccg 300
accgcgcccc cgtcacaccc cacaacccgt cgcgatccag ctcagccacg atctccacaa 360
tgcgcccatc aatcgcattg cgctgaacgg gcaactccgc caactcctcc aa 412




662


467


DNA


Mycobacterium tuberculosis



662
aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagatc 60
tggtacccat ccgtgataca ttgaggctgt tccctggggg tcgttacctt ccacgagcaa 120
aacacgtagc cccttcagag ccagatcctg agcaagatga acagaaactg aggttttgta 180
aacgccacct ttatgggcag caaccccgat caccggtgga aatacgtctt cagcacgtcg 240
caatcgcgta ccaaacacat cacgcatatg attaatttgt tcaattgtat aaccaacacg 300
ttgctcaacc cgtcctcgaa tttccatatc cgggtgcggt agtcgccctg ctttctcggc 360
atctctgata gcctgagaag aaaccccaac taaatccgct gcttcaccta ttctccagcg 420
ccgggttatt ttcctcgctt ccgggctgtc atcattaaac tgtgcaa 467




663


452


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






663
aacagctatg accatgatta cgccaagcta tttaggtgac actatagaat actcaagctt 60
ancgccacct cccgggcgga actccacggc gtggatnaag gtaccggccg ggatgttgcg 120
caatggcagg ttgttgcccg gcttgangtc cgcgttagcg ccggattcca ccacatcccc 180
ttgcgaaant ccgttgggtn cnatgatgtn ncgcttctcc ccntcnanat aatggancaa 240
cgcnatccgt gcggtacggt tcgggtcnta ctccatgtnc gcgaccttgg cgttganacc 300
atctttgtca ttgcggcgaa agtcnatcat ccggtnagcn cgcntatgan cgccgccttt 360
gtgccgggtg gtaatccggc catgcgcntt gcgtccaccg cgaacgtgca acgggggcnc 420
caacganttc tccngggttg aaccggtnat ct 452




664


93


DNA


Mycobacterium tuberculosis



664
tgtgtgtggt ggtaacccat ctgagcagtg tgccaaaccg gggcagccag ctcccaattg 60
acgtgagccc gctcacttgc tgggtaagcg tcg 93




665


352


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






665
aacagctatg accatgatta cgccaagcta tttaggtgac actatanaat actcaagctt 60
gcgggtnatn gccttggtca acggcaccgt gatcggatcn gggtctaccg cacacatnga 120
ctggagcttc ggcgaantca tcgcctatgc ctcgcggggg gtgacgctga ncccnggtga 180
cntgttcngc tcnggcacgg tgcccacctg cacgctcntc naacacctca ngccaccgga 240
atcattcccn ggctggctgc acganagcga nnttgtcncc ctccaagtct aaaggctggg 300
cgananaagc anaacgtccc gacnaacggc actccttttc cntttgctct tc 352




666


448


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






666
gaaatcattg atggtttgag tcaccaggcc gatcaagcct tcgccgagcc aaattccaat 60
caagaggccc aagcccgtac caatcagccc ggcaacgagg gattccgtca ttatcagcca 120
aaataactgc tctcgggtta cacccaaaca gcgcaatatg gcgaaaaacg gtcgccgttg 180
cacgacatta aatgtcacgg tattgtagat taaaaagata cccaccaaca angcaatcaa 240
actgagagcg gttaaattga ccgtaaaagc gtccgtcatc tgtttgacng tgtcccgttg 300
ggtatccgac gtttccatac gcacaccggc cggcagtctt tgttggatgc gtnttgcaat 360
ggcctcatct ttgatgatca aatcgatgtn gctcagtctt ccgggcatat ggaacaactc 420
ttgggccgtg gaaatatcag caatgata 448




667


386


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






667
ctttcgccca ggccggcgcg gatgtcctca tcgcttcacg aacatcatcc gagcttgacg 60
ctgtcgccga acagatccgc gctgccggcc gccgcgccca caccgttgcc gccgatctgg 120
cccatcccga ggtgaccgcg cagctggctg gtcaggccgt cggagctttc gggaagctcg 180
acatcgtcgt caacaacgtt ggcggcacca tgcccaacac gctgctaagc acctcgacca 240
angacctcgc ggacgccttc gccttcaacg tgggcaccgc ccacgcgctg accgtcgcgg 300
cggtgccgtt gatgctggaa cactccggcg gcggcagcgt gatcaacatc agctccacca 360
tgggccggct ggcggcgcgg ggtttc 386




668


378


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






668
tgtgggctcc gatccggcgc gcatggcatc gacggcgacg ccgatcgatg acggccaggc 60
ttacgagctt gagggtgtga agttgtggac caccaacggt gtggtagcgg acctgctagt 120
ggttatggcg cgggtaccgc gcagtgaagg gcnccgaggg ggaatcancg cctttgtcgt 180
cgaggctgat tcgcccggga tcaccgtgga gcggcgcaac aagttcatgg gactgcgtgg 240
catcgaaaac ggcgtgaccc ggcttcntcg cgtcagggtg cccaaagaca acttgatcgc 300
anggaagcga cggtctgaag atcgcgctga ccacactcaa cgccggacgg ctgtccctac 360
cggcgatcca accggagt 378




669


344


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






669
gagctggccg agctggaccg gttcaccgcg gaactaccgt tctcgctcga cgactttcag 60
cagcgggctt gcagcgcgct ggaacgcggc cacggtgtgc tggtgtgcgc gccgaccggc 120
gctggcaaga cagtggtcgg cgagttcgcc gtgcacctgg cgctggcggc cggcagtaaa 180
tgtttctaca ccacgccgct gaaagccctg agcaaccaaa agcacaccga tctcacagca 240
cgctacggcc gtgaccagat ctggctgctg accggtgacc tgtcngtcaa cggcaaccgc 300
cggtggtggt gatgaccacc gaaatgctgc gcaacatgct ctac 344




670


411


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






670
gatctctgga tcggcggggc tctccgggcc ggcctcggcg acctcagcgg gccgcgcctt 60
ccggccgaac cattccctag ccatagatga ccgcacctcg atgcacggtt tggcggcaac 120
gcggcaaggc gtcngtcggg cccagccgcg gcaatgcggg tacccgggag cgcgggtcng 180
tanaccancg ctggactgcg tcgcgcggtg cgtcnacntc aaagtccccg gcgtcccata 240
tcgcgtatga cgcgggcgcg cccggcacca ngggtgccga tccggccgtc tcgaacacca 300
ccggcccgcc agccgccgcg ggtccggcag cnaacccgcc cgcgccgata cccgctgccc 360
gcgtgcgtga ttgaccgccg cgcgcacgct ggccanggat caaagcccgt g 411




671


473


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






671
ggacgcgtag cccgccaggc cggtcagggt gcccttccag tccacgccgc tgtggtcggc 60
gaaccgctta tcttcaatcg agacgatcgc cagcttcatc gtgttggcga tcttgtccga 120
gggcacctcg aaccggcgct gcgagtncag ccacgcgatc gtgttgccct tcgcgtcgac 180
catcgtcgat accgcaggca cttgcccctc gagcagctgg gccgagccgt tggcaacgac 240
ctcagangca cgattggaca tcagccctag cccgcctgcg aacgggaacg tcagcgcagt 300
ggcgacgaca ctggccaaca gacagcaccc agccagcttc agaacggtga tcgcggccgg 360
gaagcgctcg ggcatgcgtn ctacagtagc gacctcctgt cactccacgt gccgctcggt 420
ccaatagaat ctttccgcgg gcgggtgaat ctctgcngga tcggggcngg cgc 473




672


357


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






672
gctcgttgcc ggcggcgatc tcgtcgagct cgtcttccat cgccgcggtg aagtcgtagt 60
cgacgagccg accgaaatgc tgctcgagca gaccggttac cgcgaacgcc acccatgacg 120
gcaccagtgc actgcccttc ttgtgcacgt ngccgcgatc ctggatggtc ttgatgatcg 180
acgantaggt cgacgggcgg ccgatgccca gctcctcgag cgctttgacc agcgacgcct 240
cngtgtnncg ggccggcggg ttggtggcat ggccgtctgg ggtcaactcg acnatgtcca 300
accgttgacc cggggtcaga tggggcagtc gccgctcggc atcgtcagcc tcgccgc 357




673


402


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






673
gtctttcgat ggctgcttct tcggcgctga cgctggcgat ctatcacccc cagcagttcg 60
tctacgcggg agcgatgtcg ggcctgttgg acccctccca ggcgatgggt cccaccctga 120
tcggcctggc gatgggtgac gctggcggct acaaggcctc cgacatgtgg ggcccgaagg 180
aggacccggc gtggcagcgc aacgacccgc tgttgaacgt cnggaanctg atcgccaacn 240
acacccncgt ctgggtgtac tgcggcaacn gcaagccgtc ggatctgggt ggcaacaacc 300
tgccggccaa gttcctcgag ggcttcgtgc ggaccatcaa catcaagttc caagacgcct 360
acaacgccng tggcggccac aaccgcgtgt tcgacttccc gg 402




674


336


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






674
gccaggtcga ggtcccatgc gcgtgggcca ttgatgctga tcgccaggac gtcaaanatt 60
tggtccggcg tcagctgggc gaaaaacgtg ggccccagga cttgcccgga gctgcccggg 120
ttcccgtcgc gcagctcggc ggccccggtc agaaanaaat tgcgccaggt cgcacactcc 180
gcgccgtang ccagctgctc cagggtgtcg gcatagagcc cgcgggccgc agcgtgctcg 240
ctgtcggcga acaccgcatg gtcgagaagc gttgccgccc aacggaaatc acctgcgtcn 300
aangcttcgc gggccaactc cagcactcgg tcgatg 336




675


405


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






675
naaacgttcc ggcttnggtg ccgggcgctt atttgcgtct ctgggatcac nctcagtcgc 60
cggcggctgc cgttgggcta tnanttgcac cganccggaa aatccgcacn anaactgcna 120
gtagcggcct gcagaantgc atcctcggcg aancngacta ccggtggaca ncnacaagcg 180
ccgccgaaca acgcactggc ccgagggatn ggcgtctatc ggccccgccc gtcgaactng 240
gaacagacng tgcggttcta ccgtgatctg gtgggaatgc tcnaccanac cttcccnann 300
gctacggaac nacggcgcga tattcngccn tcccanctcg agcctgacnc tngatatcgt 360
cgannctcac catcncgatc ngctgtgccg gtnttgctcg gactn 405




676


389


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






676
cgaacgacga acnccncaag ccatggtggt tggcgccgtc aaaaggtccg cggtcgccac 60
tactggaaaa tcgccttgag cgtcnctcga ccnccgcctc gagttgggtc ntaacgaaat 120
acctgatgcc gatcangtcn acgtctccgt cgcnncaacg tgcagcggcg acccactcta 180
cnangtctcg gtnccgccnc ggccagngca ccaccagtga cnaatccntg cgccntcggg 240
ccnagcantc ccggtgcnac cgnggtgggt ccggcgatgg tngggtgtnc tcnntacngg 300
aacgccagcg cnatcancat cggcanactc ncgtcgatgt gccgcggcgc aaccatcccc 360
cacaatgatc nggtgcgtct gatcaggcn 389




677


135


DNA


Mycobacterium tuberculosis



677
ttaggcgtga cggccaccgg ggccactccg cacaatctgt acccgaccaa gatctacacc 60
atcgaatacg acggcgtcgc cgactttccg cggtacccgc tcaactttgt gtcgaccctc 120
aacgccattg ccggc 135




678


140


DNA


Mycobacterium tuberculosis



678
cgtcaccccg atgcgcccag atcggggctt cgcagataaa gcacgaactg gcgggcaaaa 60
cgtcgatctc ggagccggaa gggcaatcag ccgaccgtcg acgaacgaca ccggcgagac 120
cacttaggca gtgacggcct 140




679


272


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






679
cttttcncga tgtctcatga tnccnangga gaacnntgcn ancncngccg ctgacntngc 60
ncaccgctnt ggcngnggtg acattggtgg tggttgcggg ctgcnacgcc cgactcgang 120
ccganccatn tnttgcggcc gaccgcntnt cgtctcnacc gcanncccna tctcngccgc 180
ncccggtgga nctacngctn cttcgccatc tctcgccnat ggctccngcg nntcgcncaa 240
cgtntggttt ggtnanctgc ctacctggtc nt 272




680


507


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






680
gctgcgccag tcgttcggtg cggtcatgcc gttggaccna ccatcggagt tagttgccga 60
accgcggacc accgcaagca cccggtcctg gtcgcgcacc gcgtcggcca accgcttgag 120
caccaccacg ccgcagccct cgccgcgcac gaatccatcc gcgttggcgt cnaanctgtn 180
gcatcggtcg gtcggtgaca gcgccgacca cttggacagc gcgatggcgg tgaacggtna 240
ntaggtgacc tgccnccncg cccgccaatg cccacctccg cttcacncat gcgaatggtc 300
tgacacgccn agtgaattgc caccagcgac aacaaaaatc ggtatctncn gcgacggcgg 360
acacgcnatc ccnactgata ctcgatccgc cccaccgctt gnanctccgg gttccngtgc 420
tcatgtaccn tcatgtcggt ctgcgcncga tattgacgat cgtgtttccc acgannanag 480
ancctcatca cgccggttcg agtgccg 507




681


470


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






681
ctgtgtgcgg ncggcgcgat atcggccttt ttactaaccg aacccgatgt gggctccgat 60
ccggcgcgca tggcatctac ngcgacgccg atcgatgacg gccaggctta cgagcttgag 120
ggtgtgaant tgtggaccnc caacggtgtg gtagcggacc tgctantggt tatggcgcgg 180
gtaccgcgca gtgaanggca ccgaggggga atcancgcct ttgtcgtcta ngctgattct 240
cccgggatca ccntggagcg cnccncnant tcatgggact gcgtggcatc caanacggcg 300
tgaccggctt catccntcng ggtgcccaaa gacaacttga tcngcnngga agcgacgtct 360
gaanatcgcg ctgatcncac tcaacgccgg acgctgtcct accggcgatc gcaccggant 420
tgccaanccg cgctnannat ncgcgngaat gnccgtccac nantgcatgg 470




682


346


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






682
tggggtgccg ggcgccgagt tgcgtccctg ggatcacgca gagtcgccgg cggctgccgt 60
tgggctatga attgcaccga gccggaaaat ccgcancaaa actgcgagta gcggcctgca 120
gaagtgcanc ctcggcgaaa cggagtacgg tggacaacga aaagcgccgc cgaacnacgc 180
actggcccga gggattggcg tcaatcggcc ccgcccgtcg aacttggaag anacantgcg 240
gttctaccgt gatctggtgg gaatgctcca acnnaccttc nccgaaagct acggaagcna 300
cggcgcgatn ttcggccttc ccagctcgac ctgacgctgg aaatcg 346




683


453


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






683
nggcngggaa gttaatgccc tactggttcn atgctcncac ntcnccngtg acnncctgcn 60
ccgacccgcc gaggtcctgn ccgtnaccac cgancnggcg atccgggact ctngtacgca 120
tccaacanng ancaacgtgc acgggcggag tngtnccgcc acttcgncna tgacggggtc 180
gatccnttcg acgtccgtcg ccgcgtcggt cgagtggcgg tcacnctccn ngtactcgac 240
cncacngacg agaggactcg ancccatcta cgtgtggacg aaacanatct tctgtccnac 300
gactacacca ccacccaggc catcgccgnc gcccgcgang ccccttcgac gccntactgg 360
tccngnggng gcgctctccg gttgtctnnc ncntgncgtg ttccttcacn cactgcccna 420
catcganccc gagcnatncn angtccgtca atc 453




684


382


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






684
ggacactgtt cgcgtgcccc tcgtcaaagc cggagtggtc gtgctgcgcc ggacccgacc 60
cgaccttcag cgggggttca cagctccgtg ggtgccgtta cttccgatcg ccgcagtgtg 120
cgcgtgcctg tggctgatgc tgaacctcac cgcgttgact tggatccggt tcgggatctg 180
gctggtggcc ggaaccgcga tttatgtcng ctacgggcgc cggcactcgg cgcatggcct 240
tcggcaagcn cnananaacg cgacccggag gtgttgaact agcttcgccg cgtatttaca 300
aattgcntta tatgtctaca cataagacgc aaactgctct attgtcaant cccancgtgg 360
tgtggcncat gaagatgttt gg 382




685


408


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






685
tccttctcgg tatcggtttg ggctgtcacc ancagttggt agttcttcac gtnctgttgt 60
tcgagcgtcn agccgtcgcg cgtgtcnang tcnccggacg cgtatcccgc caggccggtc 120
anggtgccct tccantccac gccgctgtgg tcggcgaacg ctnatcttca atcgagacca 180
tcgccagctt catcntgttg gcgatcttgt cnnacggcac ctcnaaccgg cgctnctagt 240
acnccacncn atcntgttnc cttcncgtcn acatcctcga tnccncntgc actttccctc 300
gancncctgg gccgagccgt tggcantnac ctcngagccc cattggacat cancccancc 360
cgcctgcgaa cgggaacgtc agcncnctgg cgacaacctg gccaacan 408




686


372


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






686
cacnccgtga tcgcnagccc cngtagaaat ngttgagcca gttggtgcgg cgctcgttgc 60
cggcggtnat ctcgtcgagc tcntcttcca tcgccgcggt gaagtcgtac tcgacnagcc 120
gaccnaaatg ctgctcnagc agaccggtta ccnnnaacnc cncctcntga cngcaccagt 180
gcnctgccct tcttgtgcac gtacccgcna tcctggatgg tcttgatgat cnactantnt 240
gtcgacgggc ggccgatgcc catctcctcn agcgctttga ccagcgacnc ctcggtgtat 300
cgggccggcg ggttngtggc atggccgtct ggggtcanct cnacnatntt canccgttga 360
cccggggtca ca 372




687


403


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






687
tggccttctt gncangggcn nacatnngct atngcgagcg tgtaaccgat catcntccng 60
gcgactgtgg cctgancggc aagggtngcc tnattcntcc tcctgnggca tggttnccac 120
acggaatgnc ggtaagtctg gtcggcaacc tggcccgctg cgggttgggt tcggattcgc 180
tcggctanta aggtgctcgc ctggtgtnac nactaatcnc natatacnct tancgggagt 240
ngncgtcccg atcctngccc tgccgcnggc gatcncgttc gcancaccgc caccggaact 300
cncaangtgc gctcatcggg ctctacgcgc catcttcccc ggattcttcg cggcngngtn 360
ccgngggacc ccggactgtg acnggcccaa cggctcatca tcg 403




688


356


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






688
ccggatagcg gtgtctgaac ttcgcccgtt ccctccancg cattgagctt cagcccgacc 60
ggcaggtnng gagtcggcat gcggtccttc gccccgaccc cgctggctaa atanccaccc 120
ccgagcgcgg tcacggtctt tgcaccggga cgacgcatac cggcagcgcg aacatcnccg 180
cgggctgcag cntgaacgtc caataccant cnaacagtgt ccgcgcgtna aaacccganc 240
cggcggtcgc ttcngtaatc aacggctcct gcgcaaccag ctgcaagtcg ccggtgccac 300
cggcgttgac gatcttgatg tctgcganct cgcgcaccag ctcgacggcc cgggca 356




689


439


DNA


Mycobacterium tuberculosis



689
cctcccgacc acatacaggc aaagtaatgg cattaccgcg agccattact cctacgcgcg 60
caattaacga atccaccatc ggggcagctg gtgtcgataa cgaagtatct tcaaccggtt 120
gagtattgag cgtatgtttt ggaataacag gcgcacgctt cattatctaa tctcccagcg 180
tggtttaatc agacgatcga aaatttcatt gcagacaggt tcccaaatag aaagagcatt 240
tctccaggca ccagttgaag agcgttgatc aatggcctgt tcaaaaacag ttctcatccg 300
gatctgacct ttaccaactt catccgtttc acgtacaaca ttttttagaa ccatgcttcc 360
ccaggcatcc cgaatttgct cctccatcca cggggactga gagccattac tattgctgta 420
tttggtaagc aaaatacgt 439




690


442


DNA


Mycobacterium tuberculosis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






690
cttcacntcc gtacggctcg ggtacgcttc ggtcncattg tgcgagtgat agatgacgac 60
cgggacctcg tcggcatctt ccatagcccg ccacaccttc agttgctcac cggaatccaa 120
ccggtanaag gtcggcganc gctcngcatt ggtcatcggg atatgccgct cgggacggtc 180
anagccctcg ggtccggcca gcactccgca ggcttcgtcg gggtggtcgc gacgcgcatg 240
ggccaccatc gcattcacca ggtctgcgcg aatcaccagc acgtanacgg ttcctttcct 300
aagcaacacc gaantttcag gacccgaatg ctccgggaaa catgtcacgg taggtcggta 360
ttccggctac cggctganca ttgagcacgc cggccagcac cgcacgaacc aggcaatcag 420
ccgccgccgc acccgaccgc gg 442




691


365


DNA


Mycobacterium tuberculosis



691
caggcatgca agcttgatgc cgccgaaacc gagcgtgagc acgccgccag ccaccacgcg 60
cgggtcgggc gccgggcccg ggccgccagg ctgctccgct cggtgatggc acgccaccgc 120
gacaccaccc ggctgcgcta cgtcgagcca taccgggcgg agctacatcg gctcggccgc 180
ccagtgttcg ggccctcttt cgaggtcgag gtcgataccg atttgcgcat ccgcagccgc 240
accctggacg acagaaccgt gccctacgaa ttgcttgtcg ggcggggcca aagaacagct 300
tggcatcctg gcgcgattgg ccggcgcggc gctggtcgcc aaggaagacc cgttccggtg 360
ctgat 365




692


307


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






692
aagntcgggt ttccacacgc gcggtttgac cctagtcata tgtaatcatg tgtaccatgt 60
gcgggcgctt ttcgacggcc gcgaaccacc gganatttcc tgtgatttca ctgcatgcgt 120
accatctggc acaattgagc anttgtctnt cgcggtggtc ggncgggttg cgtgccgcct 180
gctgcganat gcaccantaa gcccgaaccc accggcttgg tgaccaccgc acgctgcgtg 240
tggggggtaa ccactccgcg accccaagga tggtcatttc caatgaaccg gctggacttc 300
gtccana 307




693


414


DNA


Mycobacterium bovis



693
gtcgcggttc gatcgacccg atcttcacct cgtaacctcg atgcttagca ggatccagct 60
tgaccgcgtt tggctctacc cactctttga gtggcgccgt cgcctgtgcc ccatcggtgt 120
tcatgacgaa cgcttcgaaa gacttcctct tgtgagccgg aatgtctgcg taaagaagtt 180
ccatgtccgg gaagtagacc cggtcgccct ccacgtggta ctccttcgag gtccgcttct 240
cgccggatcc gataaacacc ggccccaggc accgcagcgt gagttcgaac ggcttcaggt 300
aggtgttcat gcggcggact ccgggagtgc gagaaatagc ggtcgcgcgt agctgtagac 360
cggatggttt ccgcccaggc tgacgtcgaa gatgcctcct tggaaggggc gcga 414




694


256


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






694
aactcaagtt tttacggtga tcgcgcatca cctggttcat gaactggaag cagcgcagcg 60
cttccttttc ggccgcaaca tgagccagcc tctcgtcggc ggtcgggtgc aggtgctcgg 120
gcagctcggc cgcgacagcc gcctgaccct gaaaccagct tccatatccc gcgacnaacg 180
acgccagtcc gctacgtaac ccctccgcga ctgtccatgg acaacagcgc gttctccacc 240
gaccgggccc gggtgt 256




695


328


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






695
gtgcaggttt cgacaatgtg gtgccggttc ggcggctacg tgccatcgag acactggcgc 60
angctatcgc acccgttatc ggctgcgagc aaatcgcggt atgcgttctt gagcatgagt 120
cggcgaccgt cgtcatggtc gacacccacg acggaaagac gcagatcgcc gtcaagcatg 180
tgtgccgcgg attatcagga ctgacctcct ggctgaccgg catgtttggt cgcgatgcct 240
ggcgcccggc cggcgtggtc gtggtcggct cggatagcga ggtcagcgaa ttctcgtggc 300
agctcgaaag ggtcctgccg gtgccggt 328




696


278


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






696
ttcgagtcat gcgcccgcct cgaccacgaa natgcacgtc gnggttcgat cgacccgatc 60
ttcacctcgt aacctcgatg cttagcagga tccagcttga ccgcgtttgg ctctacccac 120
tctttgagtg gcgccgtcgc ctgtgcccca tcggtgttca tgacgaacgc ttcgaaagac 180
ttcctcttgt gagccggaat gtctgcgtaa agaagttcca tgtccgggaa gtagacccgg 240
tcgccctcca cgtggtactc cttcgaggtc cgcttctc 278




697


264


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






697
gtcatgtgta ccatttgcgg gcgcttttcg acggccgcga aacaccggag atttcctgtg 60
atttcactgc atgcgtaccg tctggcacaa ttgagcagtt gtctgtcgcg gtggtcggcc 120
gggttgcgtg ccgcctgctg cgagatgcac caataagccc gaacccaccg gcttggtgac 180
caccgcacgc tgcgtgtggg gggtaaccac gccgcgaccc caaggatggt catttccaat 240
gaaccggctg gacttcntca acaa 264




698


169


DNA


Mycobacterium bovis



698
aacagcgcgg ttgaactgat aggtgcggcc cggctcgagc aggccgggcc atttgttcga 60
tgcggttacc gaaagatctc ttcggtgacc tgcccgccgc cggccagctc ggcccagtgc 120
ccggcgttgg ccgccgcggc gacgatcttg gcgtccacgg tggtcgggg 169




699


256


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






699
gcatctgggc tggcggtggt tcgccgctcc gaagccgtcg aacaccatcg ccagcgcggc 60
ttccacatca acgaccattt cggccagctt gcggcgcatc agcggcttgt cgatgagcgc 120
cccaccgaat gcccgccgct gcccggcgta ncacagcgat tcgaccagcg cgcggcgcgc 180
gttgccgagg gcgaacgaag cggtgcccaa ccgcaatctg ttggtcagct ccatcatgcg 240
ggtgagtccc ttgccg 256




700


291


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






700
atcggtttcc agcaacagcc gatcgacggc ttcgcccagg ccgctcccgg gcgacccgac 60
cattgctgtc gccgcgtaac gccatcacgg atgacgcgca gttcgtcgct gtctagctcc 120
accatcgcct gcacaccggc ggccagnacc cattggccgt cgcactcgta nagcaggtaa 180
tcctcgtcga cggactcggt aaccaccgcc gccagctccg ctgccaggtc ggcggggttg 240
acaccggcgg gcatcgggat ggacgacgac gcggtgctga cggcgcctgt c 291




701


315


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






701
agcggtttcc cangcgggat gtgctgtgag cgccgcacca ccagcgccga cgctaaggat 60
ggaacgcacg gcatcttctg acgcgtaacc gcgttgtgat cgcgagctga ggagacggta 120
tgggggaggg ttctcggagg ccatctggga tgttgatgtc tgtcgatctt gagccggtgc 180
aactcgtcgg cccggacggt acgccgacgg ccgaacgccg ctaccaccgt gaccttcctg 240
aggaaacgct gcgttggctc tacgagatga tggtggtcac ccgcgagctg gataccgaat 300
tcgtcaatct gcacg 315




702


328


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






702
caagcttcca caggtaggga tcgaggaaca gcgcgttgaa ctgataggtg cggcccggct 60
cgagcaggcc ggccatttgt tcgatgcggt taccgaaaat ctcttcggtg acctgcccgc 120
cgccggccag ctcggcccag tgcccggcgt tggccgccgc ggcaacgatc ttggcgtcca 180
cggtggtcgg ggtcatgccc gcgagcagga tcggcgagcg gccggtcagc cgggtgaact 240
tcgtcgaaag cttgaccctg ccgtcgggga ggcgaaccac ggtcggtgcg tanctccacc 300
aagcccgggc aacctcgggg gtggcgcc 328




703


352


DNA


Mycobacterium bovis



703
tggacctcat gacaacgcgg cggcgattac ccccgctacc gccagcagca tgacggcggt 60
agcgaacacc gccggatgca gcgcaggtgc gtcgatgtgc tcacggaatc gccccggcac 120
cgcgatctcg aggatcacca gtgccacccc ctgcagcgcg acaccgacga ttccgtacac 180
cgccacgccg atcaggccct gggccagctg gcgtatatgg cggcgatggt gacgatggcc 240
agcgccacat acattgtggc ggccagaacc acggcgttgg ggcggcggtc gatgaacact 300
aggcgacgca gatcgcccgg ggtcaacagg ttgaccatca gaaagcctgc ga 352




704


315


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






704
tttggtgcgg ccggcaatca acttcngctc ncagcggttt cccaggcggg atgtgctgtg 60
agcgccgcac caccagcgcc gacgctaagg atggaacgca cggcatcttc tgacgcgtaa 120
ccgcgttgtg atcgcgagct gaggagacgg tatgggggag ggttctcgga ggccatctgg 180
gatgttgatg tctgtcgatc ttgagccggt gcaactcgtc ggcccggacg gtacgccgac 240
ggccgaacgc cgctaccacc gtgaccttcc tgaggaaacg ctgcgttggc tctacgatat 300
gatggtggtc acccg 315




705


390


DNA


Mycobacterium bovis



705
cgcccagggc cgctcccggg cgacccgacc attgctgtcg ccgcgtaacg ccatcacgga 60
tgacgcgcag ttcgtcgctg tctagctcca ccatcgcctg cacaccggcg gccaggaccc 120
attggccgtc gcactcgtag agcaggtaat cctcgtcgac ggactcggta accaccgccg 180
ccagctccgc tgccaggtcg gcggggttga caccggcggg catcgggatg gacgacgacg 240
cggtgctgac ggcgcctgtc gcgacgctga gctcggacac agctagtaaa tgtagcctaa 300
cctacttaat gggtcgcagc cccccggggt cgtcgcatgt ccaacgttgc tcgactggaa 360
gaaaatgctc gtcggggagc aaatggcacc 390




706


322


DNA


Mycobacterium bovis



706
aatactcaat cttgatcggt ttccagcaac agccgatcga cggcttcgcc cagggccgct 60
cccgggcgac ccgaccattg ctgtcgccgc gtaacgccat cacggatgac gcgcagttcg 120
tcgctgtcta gctccaccat cgcctgcaca ccggcggcca ggacccattg gccgtcgcac 180
tcgtagagca ggtaatcctc gtcgacggac tcggtaacca ccgccgccag ctccgctgcc 240
aggtcggcgg ggttgacacc ggcgggcatc gggatggacg acgacgcggt gctgacggcg 300
cctgtcgcga ctctgagctc gg 322




707


398


DNA


Mycobacterium bovis



707
ggatgtgctg tgagcgccgc accaccagcg ccgacgctaa ggatggaacg cacggcatct 60
tctgacgcgt aaccgcgttg tgatcgcgag ctgaggagac ggtatggggg agggttctcg 120
gaggccatct gggatgttga tgtctgtcga tcttgagccg gtgcaactcg tcggcccgga 180
cggtacgccg acggccgaac gccgctacca ccgtgacctt cctgaggaaa cgctgcgttg 240
gctctacgag atgatggtgg tcacccgcga gctggatacc gaattcgtca atctgcagcg 300
ccagggggaa gctggcgttg tacacgccct gtcgcgggca ggaagccgcg caggtgggtg 360
cggcggcttg cctacgcaaa accgactggt tgttcccc 398




708


175


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






708
atcacgacaa cagcgacggt gtgtcggatc agcggccccc gttgccgggc aatgttgagg 60
cgtttctgcg tctggttgag gccggctggg acnccgaggt ggctcgtcgg ccacatgggc 120
agcacaccac cgtggtgatg catctagacg tgcaggaccg tgccgctggc ctgca 175




709


210


DNA


Mycobacterium bovis



709
gcggctacgt gccatcgaga cactggcgca ggctatcgca cccgttatcg gctgcgagca 60
aatcgcggta tgcgttcttg agcatgagtc ggcgaccgtc gtcatggtcg acacccacga 120
cggaaagacg cagatcgccg tcaagcatgt gtgccgcgga ttatcaggac tgacctcctg 180
gctgaccggc atgtttggtc gcgatgcctg 210




710


312


DNA


Mycobacterium bovis



710
tacaagcggc acctcgccgg tgaactgacc gttcgcacgc tgcgcaccgc cgccgggcgc 60
gtgctcggcg cgccggcggc ccccgaggcc tgagagggga accaaccatg caggtgaaca 120
tgacggtaaa cggcgagccc gtcaccgccg aggtcgaacc ccggatgctg ctggtccatt 180
ttctccgtga tcagctgcgg ctcaccggaa ctcactgggg ctgtgatacc agcaactgcg 240
ggacatgcgt ggtggaggtc gacggcgtgc cggtgaaatc ctgcacgatg ctcgccgtga 300
tggcctccgg gc 312




711


255


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






711
agcggctggt tacgactccc tgtttgtgat ggaccacttc taccaactgc ccatgttggg 60
gacgcccgnc cntccgatgc tggaagccta cactgccctt ggtgcgctgg ccncngcgac 120
cgagcggctg caactgggcg cnttggtgac cngcaatacc taccgcaccc cnaccctgct 180
ggncaaanat catcaccacg ctcgacttgg ttagcgccgg tcgancgatc ctcggcattg 240
gaaccggttg gtttn 255




712


304


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






712
acgcgcgccg atcatatctg ctatggatgt acaattcagc tcttgctgtt ataccagtat 60
atggtgtact atttgatcta tgctgacgtg tgagatgcgg gaatcggccc tggctcgact 120
cggccgggct ctggctgatc cgacgcggtg ccggattctg gtggcgttgc tggatggcgt 180
ttgctatccc ggccagctag ctgcgcacct cgggttgacc cgatcgaatg tgtccaacca 240
tctgtcgtgt ttgcggggct gcgggctggt antcccaacc tatgagggcc ggcaggttcg 300
gtat 304




713


352


DNA


Mycobacterium bovis



713
ccgcgctgct gctgacgtcg gtcgaacgtg cgacacgtct gcgaataccg gccgaacgct 60
gggtttatcc acaggctggc accgacgccc acgacacacc ggccgtcgcc gaccgccacc 120
gactgcatcg gtcgacggcc attcggatcg ccggtgcccg ggcgctggaa ctggctgggc 180
tggggctcga tgacatcgaa tacgtcgacc tgtattcgtg ctttccctcc gctgtccaag 240
tcgccgcaat cgaactcggc ctggacaccg acgatcctgc ccgcccgctg accgtcaccg 300
ggggcctgac cttcgccggc gggccgtgga gcaattacgt cacgcactcc at 352




714


233


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






714
caggcgtgca atgacctgca ctgcgccgga nantccctaa cccactaaac cggggccgct 60
cacaagccgt gcagctcggt cagcgtcagg tgcgcgacca ggaantaaat gagcagaccc 120
gtgccgtcaa cgatggtggc gatcatcggc cccgaaacga tggccgggtc natgcgcaac 180
ttcttcagca gcggcggaag gacggcancc accagcgacn accacaccac gat 233




715


335


DNA


Mycobacterium bovis



715
gcgaacactt cgtcaacttc cagggctgcc cgcaccaagt atttcgacga gtatttccgt 60
cgggccgccg ccgccggcgc gcggcaggtg gtcatcctgg cggcggggct ggactcgcgc 120
gcgtaccggc tgccttggcc cgacgggacc acggtttttg agctggaccg cccgcaggtc 180
cttgatttca agcgcgaggt gctcgccagc cacggtgccc aaccgcgcgc cctgcgccgc 240
gagatcgccg tcgacctgcg tgacgattgg ccacaagcct tgcgggacag tggtttcgat 300
gcggctgcac cgtcggcatg gattgccgaa gggct 335




716


274


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






716
ttgggcnttg cccncaatan ggccccaatc aaaagccgag caggtggaac ctanncgcat 60
tcgcctcntc gtntgtgcac ccgagccatc gcacgcgcgg gaattcccgg atntcnccgt 120
attctccggc ggccgggcta acccatccca ngccgaacgg ttggctcntg ccgtgggtcc 180
cgtgttggcc gatcggggcg tcaccggggg tgctcgggtg cggntgacca tggcnaactg 240
ccccnatggg ccgaccctgg tgcagataaa cctg 274




717


327


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






717
tggtggaggt ccccaccaan acccggccgt aactctgctc acggaaatgc ggncaggccg 60
cgcgtagcac gtggtatccg ccataaaggt gcaccttaag cacggcgtcc caattctcga 120
acgacatctt gtggaaggtg ccgtcgcgca agatcccggc gttgctcacc acaccgtgca 180
cggcgccgaa ttcgtcaagc gcggtcttga tgatgttcgc tgcgccgtcc tcggtggcga 240
cgctgtcggt anttggcgac cgcccggccc cccttgtcgc gaaatctcgg cgacgacctc 300
atcggccatc gccgaaccgg gcgcccg 327




718


344


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






718
gccggccaaa ctggccggcg gggttgctgt cntcaaggtg ggttccgcca ccaanaccnc 60
actcaaggat cgcaaggaaa gcntcaagga tgcggtcgcg gccgccaagg ccgcggtcaa 120
ggagggcatc gtccctggtg ggggancctc cctcatccac caggcccgca aggcgctgac 180
cgaactgcnt gcgtcncnga ccggtgacaa ngtcctcggt gtccacgtgt nctccgaagc 240
ccttgccgct ccgttgttct ggatcnccnc caacnctggc ttggacggct cngtggtggt 300
caacaaggtc agcgagctac ccgccgggca tgggctgaac gtga 344




719


271


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






719
cgaacctnaa ttgtcctgta atgcccagct caccaangca tggctggtgg ccggggcggt 60
gaagccggcg tctgcggcac cgtccaactc natgtggatn gccggaatgg ggatgtccgg 120
nacggcgaat ccgtanttcg cttgtcccgt gaggcccagg tggatggggg gaaggatcnt 180
ggtgtccggg atgatnatgg ggccgatgcc gccggttgaa gtccactgga tcgggaattc 240
gggaatcgtg atnccgacgt tcaggccgaa c 271




720


302


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






720
ctaacggaat gaaagccctg gtggccgtnt cggcggtggc cgtcgtcgca ctgctcggtg 60
tatcttccgc ccaagctgat cccgaggcgg atcccggcgc aggtgaggcc aactatggtg 120
gccccccaag ttccccacgt cttgtcgatc acaccgaatg ggcgcantgg ggaattctgc 180
ccagcctccg ggtctacccg tcccaagttg ggcgtacanc ctcccgccgc ctcgggatgg 240
ccgctgccga cccggcctgg gccnaggttc tcgcgctgtc accggaagcc gacactgccg 300
gc 302




721


303


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






721
ccgcgggaca cncctcnatg ctgccgccat ggacgcggtc gaacgcaagc agctgatcga 60
gctacaacgc cgcgcggaac gcttccgccg cgggcgtgac cgcatcccgt tgaccgggcg 120
gatcgcggtg atcgtcgatg acggcatcgc caccggagcg acggccaagg cggcgtgcca 180
ggtcgcccgg gcgcacggtg cggacaaggt ggtgctggcg gtcccgatcg gcccanacga 240
catcgtggcg aagattcgcc gggtacgccg atgatgtggt gtgtttggcg acgccggcgt 300
tgt 303




722


280


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






722
ctctgggacc ggccacggtg ccnccggcgt tcccggacgt gctgcgccag gtgtccggcg 60
gccgcgtgca tggtgttccc ggatcggccg ctggccagag cccaccggtg aatctggcgc 120
ctggccgacc accgtgcgcc gtaggcttgc gatcgtgcag cgctggcgtg gccaggacga 180
gatcccgacg gattggggca gatgcgtgct caccatcggg gtatttgacg gcgtgcaccg 240
cgggcacgcc gaactgatcg cgcacgcggt caaaggcggc 280




723


333


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






723
aatactcaag ctttcgtcag ttcattgcgc cagcagacca acaanagcat cgggacatac 60
ggantcaact acccggccaa cggtgatttc ttggccgccg ctgacggcgc gaacgacgcc 120
agcgaccacn ttcagcaaat ggccancgcg tgccgggcca cgaggttggt gctcggcggc 180
tactcccagg gtgcggccgt gatcnacatc ntcaccgccg caccactgcc cggcctcggg 240
ttcacgcagc cgttgccgcc cgcagcggac natcacatcg ccgcgatcgc cctgttcggg 300
aatccctcng gccgcgctgg cgggctgatt aac 333




724


320


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






724
tgccgcggat ttggctggct gcccaatatt cagaatcggg cctttctttt tgcgcgacaa 60
taaggtcaca gtaaaccctc gttttgtgag atgcggggcg ggccgggcga antcgacctc 120
gagtgaatgg atctcgagtg aatggacagg gcatcgccta cgagtcgcat ccccatccaa 180
cagaccggtg ctcttgcatc ggaccctgaa ggtcccgcac ggagggtgtg gttgccggcg 240
cggggtcacg gtgcggtagc gacgtagtgt ttgaacgaat ttcttgatgc tccaacctgt 300
ttggtgttca atccagttct 320




725


296


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






725
aancttgcgc gctcggccgg gtcnagcatc cagctgctcg gcaaggaggc cagctacncn 60
tcgctgcgta tgcccagcgg tgagatccgc cgggtcnacg tccgctgccg cgcgaccgtc 120
ggcgaagtgg gcaatgccga gcaggcaaac atcaactggg gcaaggccgg tcggatgcgg 180
tggaagggca agcgcccgtc ggtccggggc gtggtgatna acccggtcna ccacccgcac 240
ggcggtggtg agggtaaaac ctccggcggc cgtcacccgg ttagcccgtg gggcaa 296




726


304


DNA


Mycobacterium bovis




unsure




(various positions within the sequence)




applicants are uncertain of bases designated
as “n”






726
antcgaaagt gaccatctct accttgagtg ccataccgcc cgaccctatg cctcggatag 60
ctcggcggaa agaaacgctt gcagtgccgc cgaataggcg gctacgtcgt gagcgcccat 120
caactctcgc gcggagtgca tcgccagctg ggcggcgccg acgtcgaccg tggggattcc 180
ggtgcgcgcc gcggccaacg gcccgatcgt cgacccgcac ggcagatcgg cgcgatgttc 240
gtaacgctgc ataggcactc ccgcgcgctg gcaggccagt gcgaacgccg ccgcggtgcg 300
tccg 304




727


318


PRT


Mycobacterium sp.



727
Pro Thr Gln Thr Leu Thr Gly Arg Pro Leu Ile Gly Asn Gly Thr Pro
1 5 10 15
Gly Ala Val Gly Ser Gly Ala Thr Gly Ala Pro Gly Gly Trp Leu Leu
20 25 30
Gly Asp Gly Gly Ala Gly Gly Ser Gly Ala Ala Gly Ser Gly Ala Pro
35 40 45
Gly Gly Ala Gly Gly Ala Ala Gly Leu Trp Gly Thr Gly Gly Ala Gly
50 55 60
Gly Ala Gly Gly Ser Ser Ala Gly Gly Gly Gly Ala Gly Gly Ala Gly
65 70 75 80
Gly Ala Gly Gly Trp Leu Leu Gly Asp Gly Gly Ala Gly Gly Ile Gly
85 90 95
Gly Ala Ser Thr Val Leu Gly Gly Thr Gly Gly Gly Gly Gly Val Gly
100 105 110
Gly Leu Trp Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly Thr Gly Leu
115 120 125
Val Gly Gly Asp Gly Gly Ala Gly Gly Ala Gly Gly Thr Gly Gly Leu
130 135 140
Leu Ala Gly Leu Ile Gly Ala Gly Gly Gly His Gly Gly Thr Gly Gly
145 150 155 160
Leu Ser Thr Asn Gly Asp Gly Gly Val Gly Gly Ala Gly Gly Asn Ala
165 170 175
Gly Met Leu Ala Gly Pro Gly Gly Ala Gly Gly Ala Gly Gly Asp Gly
180 185 190
Glu Asn Leu Asp Thr Gly Gly Asp Gly Gly Ala Gly Gly Ser Ala Gly
195 200 205
Leu Leu Phe Gly Ser Gly Gly Ala Gly Gly Ala Gly Gly Phe Gly Phe
210 215 220
Leu Gly Gly Asp Gly Gly Ala Gly Gly Asn Ala Gly Leu Leu Leu Ser
225 230 235 240
Ser Gly Gly Ala Gly Gly Phe Gly Gly Phe Gly Thr Ala Gly Gly Val
245 250 255
Gly Gly Ala Gly Gly Asn Ala Gly Trp Leu Gly Phe Gly Gly Ala Gly
260 265 270
Gly Val Gly Gly Ser Ala Gly Leu Ile Gly Thr Gly Gly Asn Gly Gly
275 280 285
Asn Gly Gly Thr Gly Ala Asn Ala Gly Ser Pro Gly Thr Gly Gly Ala
290 295 300
Gly Gly Leu Leu Leu Gly Gln Asn Gly Leu Asn Gly Leu Pro
305 310 315




728


334


PRT


Mycobacterium sp.



728
Pro Thr Gln Thr Leu Thr Gly Arg Pro Leu Ile Gly Asn Gly Thr Pro
1 5 10 15
Gly Ala Val Gly Ser Gly Ala Thr Gly Ala Pro Gly Gly Trp Leu Leu
20 25 30
Gly Asp Gly Gly Ala Gly Gly Ser Gly Ala Ala Gly Ser Gly Ala Pro
35 40 45
Gly Gly Ala Gly Gly Ala Ala Gly Leu Trp Gly Thr Gly Gly Ala Gly
50 55 60
Gly Ile Gly Gly Ala Ser Thr Val Leu Gly Gly Thr Gly Gly Gly Gly
65 70 75 80
Gly Val Gly Gly Leu Trp Gly Ala Gly Gly Ala Gly Gly Ala Gly Gly
85 90 95
Thr Gly Leu Val Gly Gly Asp Gly Gly Ala Gly Gly Ala Gly Gly Thr
100 105 110
Gly Gly Leu Leu Ala Gly Leu Ile Gly Ala Gly Gly Gly His Gly Gly
115 120 125
Thr Gly Gly Leu Ser Thr Asn Gly Asp Gly Gly Val Gly Gly Ala Gly
130 135 140
Gly Asn Ala Gly Met Leu Ala Gly Pro Gly Gly Ala Gly Gly Ala Gly
145 150 155 160
Gly Asp Gly Glu Asn Leu Asp Thr Gly Gly Asp Gly Gly Ala Gly Gly
165 170 175
Ser Ala Gly Leu Leu Phe Gly Ser Gly Gly Ala Gly Gly Ala Gly Gly
180 185 190
Phe Gly Phe Leu Gly Gly Asp Gly Gly Ala Gly Gly Asn Ala Gly Leu
195 200 205
Leu Leu Ser Ser Gly Gly Ala Gly Gly Phe Gly Gly Phe Gly Thr Ala
210 215 220
Gly Gly Val Gly Gly Ala Gly Gly Asn Ala Gly Trp Leu Gly Phe Gly
225 230 235 240
Ala Gly Gly Ile Gly Gly Ile Gly Gly Asn Ala Asn Gly Gly Ala Gly
245 250 255
Gly Asn Gly Gly Thr Gly Gly Gln Leu Trp Gly Ser Gly Gly Ala Gly
260 265 270
Val Glu Gly Gly Ala Ala Leu Ser Val Gly Asp Thr Gly Gly Ala Gly
275 280 285
Gly Val Gly Gly Ser Ala Gly Leu Ile Gly Thr Gly Gly Asn Gly Gly
290 295 300
Asn Gly Gly Thr Gly Ala Asn Ala Gly Ser Pro Gly Thr Gly Gly Ala
305 310 315 320
Gly Gly Leu Leu Leu Gly Gln Asn Gly Leu Asn Gly Leu Pro
325 330




729


650


DNA


Mycobacterium sp.



729
gcggccgcaa ggggttcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg 60
cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat 120
gcgtaaggag aaaataccgc atcaggcgcc attcgccatt caggctgcgc aactgttggg 180
aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg 240
caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg 300
ccagtgaatt gtaatacgac tcactatagg gcgaattcga gctcggtacc cggggatcct 360
ctagagtcga cctgcaggca tgcaagcttg agtattctat agtgtcacct aaatagcttg 420
gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt atccgctcac aattccacac 480
aacatacgag ccggaagcat aaagtgtaaa gcctggggtg cctaatgagt gagctaactc 540
acattaattg cgttgcgctc actgcccgct ttccagtcgg gaaacctgtc gtgccagctg 600
cattaatgaa tcggccaacg cgaacccctt gcggccgccc gggccgtcga 650




730


8


PRT


Mycobacterium sp.




Unsure




(1-8)




applicants are uncertain of residues
designated as “xaa”






730
Asn Xaa Gly Xaa Gly Asn Xaa Gly
1 5




731


9


PRT


Mycobacterium sp.




Unsure




(1-9)




applicants are unsure of residues
designated as “xaa”






731
Gly Xaa Xaa Ser Val Pro Xaa Xaa Trp
1 5




732


29


PRT


Mycobacterium sp.



732
Gly Gly Ala Gly Gly Ala Gly Gly Ser Ser Ala Gly Gly Gly Gly Ala
1 5 10 15
Gly Gly Ala Gly Gly Ala Gly Gly Trp Leu Leu Gly Asp
20 25




733


45


PRT


Mycobacterium sp.



733
Gly Ala Gly Gly Ile Gly Gly Ile Gly Gly Asn Ala Asn Gly Gly Ala
1 5 10 15
Gly Gly Asn Gly Gly Thr Gly Gly Gln Leu Trp Gly Ser Gly Gly Ala
20 25 30
Gly Val Glu Gly Gly Ala Ala Leu Ser Val Gly Asp Thr
35 40 45




734


21


DNA


Mycobacterium sp.



734
agttagctca ctcattaggc a 21




735


21


DNA


Mycobacterium sp.



735
ggatgtgctg caaggcgatt a 21




736


27


DNA


Mycobacterium sp.



736
aaacagctat gaccatgatt acgccaa 27




737


24


DNA


Mycobacterium sp.



737
tcctctagag tcgacctgca ggca 24




738


18


DNA


Mycobacterium sp.




variation




(1-18)




bases designated as “n” may be A,T,C or G





738
tctagannnn nntccggc 18




739


18


DNA


Mycobacterium sp.




variation




(1-18)




bases designated as “n” may be A, T, C or G





739
tctagannnn nngggccc 18




740


20


DNA


Mycobacterium sp.




variation




(1-20)




bases designated as “n” may be A, T, C, or G





740
cgtttaaann nnnwaggccg 20




741


21


DNA


Mycobacterium sp.




variation




(1-21)




bases designated as “n” may be A, T, C, or G





741
ggtactagtn nnnnwtccgg c 21




742


22


DNA


Mycobacterium sp.



742
acgacctcat attccgaatc cc 22




743


23


DNA


Mycobacterium sp.



743
gcatctgttg agtacgcact tcc 23






Claims
  • 1. A purified polynucleotide consisting of SEQ ID NO:1.
  • 2. A purified polynucleotide, comprising SEQ ID NO:2.
  • 3. A purified polynucleotide, comprising SEQ ID NO:3.
  • 4. A purified polynucleotide comprising SEQ ID NO:4.
  • 5. A purified polynucleotide comprising SEQ ID NO:5.
Parent Case Info

This is a division of application Ser. No. 09/060,756, filed Apr. 16, 1998 now U.S. Pat. No. 6,183,957 which is Feb. 6, 2000 incorporated herein by reference.

Foreign Referenced Citations (4)
Number Date Country
WO9303187 Feb 1993 WO
WO9318186 Sep 1993 WO
WO-9723624 Jul 1997 WO
WO9954487 Oct 1999 WO
Non-Patent Literature Citations (13)
Entry
GenEmbl AD00001 Dec. 3, 1996.*
GenEmbl AD000017 Dec. 10, 1996.*
GenEmbl U00013 Mar. 1, 1994.*
GenEmbl X63508 Nov. 20, 1996.*
Brosch et al., “Use of a Mycobacterium Tuberculosis H37Rv Bacterial Aritificial Chromosome Library for Genome Mapping Sequencing, and Comparative Genomics,” Infection and Immunity, vol. 66, No. 5, pp. 2221-2229 (May 1998).
Cole et al., “Deciphering the Biology of Mycobacterium Tuberculosis from the Complete Genome Sequence,” Nature, vol. 393, pp. 537-545 (Jun. 11, 1998).
Cole et al., Novartis Foundation Symposium, pp. 160-177 (1998).
Philipp et al., “Physical Mapping of Mycobacterium bovis BCG Pasteur Reveals Differences from the Genome Map of Mycobacterium tuberculosis H37Rv and from M. bovis,” Microbiology, vol. 142:3135-3145 (1996).
Philipp et al., “An Integrated Map of the Genome of the Tubercle Bacillus, Mycobacterium Tuberculosis H37Rv, and Comparison with Mycobacterium leprae,” Microbiology, vol. 93:3132-3137 (1996).
Zimmer et al., “Construction and Characterization of Large-Fragmented Chicken Bacterial Artificial Chromosome Library”, Genomics, vol. 42:217-226 (1997).
Kim et al., “Construction and Characterization of a Human Bacterial Artificial Chromosome Library,” Genomics, vol. 34, pp. 213-218 (Jun. 1, 1996).
International Search Report of PCT/IB99/00740.
Philipp et al., “An Integrated Map of the Genome of the Tubercle Bacilus, Mycobacterium Tuberculosis H37Rv, and Comparison with Mycobacterium leprae,” PNAS, vol. 93:3132-3137 (1996).