Patent Application
20070281029
The present invention is described in more detail below.
The present invention comprises at least a first step of preparing a pre-polymer, a second step of preparing a complex containing the pre-polymer, and a third step of coating on an object for coating process with the complex and polymerizing the complex in this state. Each step will be specifically explained as follows:
[First Step]
The first step comprises mixing an acryl monomer with an ultraviolet initiator and irradiating on the mixture with ultraviolet rays to prepare a pre-polymer having an appropriate viscosity The viscosity of pre-polymer is allowed to be in a range of 200 cps˜10,000 cps by regulating irradiation intensity and time of ultraviolet rays. If the viscosity is too low as much as less than 200 cps, the thickness is difficult to be regulated on coating. To obtain the desired thickness, coating must be repeated by several times, which is a troublesome matter. If the viscosity is too high as much as in excess of 10,000 cps, the mixing procedure in the second step is not easily occurred.
It is preferred to use monomers that Tg of the mixed system may be in a range of 0° C.˜−50° C. (below zero) by appropriately setting a mixing ratio of a monomer having a high glass transition temperature (Tg) and a monomer having a low Tg, as an acryl monomer. The term “glass transition temperature of the mixed system” is meant to a glass transition temperature that each monomer is polymerized to obtain a copolymer.
Examples of monomers having a high glass transition temperature include acrylic acid, methacrylic acid, methyl methacrylate, and the like, whereas examples of monomers having a low glass transition temperature include 2-ethylhexyl acrylate, butyl acrylate, isooctyl acrylate, hydroxybutyl acrylate, etha-caprolactone acrylate, and the like.
In addition, monomers having intermediate ranges (60° C.˜−30° C. (below zero)), for example, methylacrylate, hydroxyethyl methacylate, or hydroxypropyl acrylate, may be used as said acryl monomer.
Said ultraviolet initiator may be used by mixing one or two or more species selected from the group consisting of, for example, 1-hydroxycyclohexlphenyl ketone, 2,2-dimethoxy-2-phenyl-acetophenone, xanthone, benzaldehyde, anthraquinone, 3-methylacetophenone, 4-chlorobenzophenone, 4,4′-dimethoxy benzophenone, 4,4′-diaminobenzophenone, benzoin propyl ether, benzoin ethylether, 1-(4-isopropyl-phenol)-2-hydroxy-2-methyl propane-1-one, and thioxanthone. A commercially available initiator may be used by mixing one or two or more species selected from the group consisting of Irga-cure series from Ciba-Geigy (Swiss), Darocur series from Merck (Germany), and Lucirine series from BASF (Germany). Such ultraviolet initiator is not specifically limited, but preferably used by mixing 0.002˜2 parts by weight relative to 100 parts by weight of an acryl monomer.
In said ultraviolet irradiation, an industrially available ultraviolet lamp such as a metal halide lamp, a mercury lamp, and a black light lamp may be usually used. Such ultraviolet irradiation may be performed in vacuo or in an inert gas such as argon and helium or air. Irradiation intensity and time of ultraviolet rays vary with species and amounts of the used monomers. If the ultraviolet rays are irradiated at an intensity of 0.01 mW/cm2˜5.0 mW/cm2 for 1˜180 seconds, a pre-polymer with a viscosity of 200 cps˜10,000 cps, preferably, 1,000 cps˜5,000 cps may be prepared.
In addition, the temperature of reactants (an acryl monomer+an ultraviolet initiator) is, preferably, kept at 30° C. or below. When the ultraviolet rays are irradiated, the reaction is initiated and the temperature is elevated by heat of reaction in the reactant. If the reaching temperature of reactant after irradiating ultraviolet rays raises 5° C.˜20° C., preferably, about 10° C. more than the temperature prior to irradiation, the reaction is preferably terminated. The reason is because it is difficult to perform mixing of the second step and coating of the third step on the ground that if the temperature after irradiation raises much higher than the temperature prior to irradiation, that is, if the temperature after irradiation raises too high as much as in excess of 50° C. (wherein the temperature before irradiation is 30° C.), the product (pre-polymer) is changed into higher molecular weight material and has a high viscosity. Such termination of reaction may be attained by inhibiting a radical reaction using oxygen (referred to step 1-1).
[Second Step]
The second step comprises mixing the pre-polymer prepared in said first step with at least an ultraviolet photoinitiator and a high absorbent substance to prepare one complex. Said complex has, preferably, a viscosity of 500 cps˜50,000 cps.
The ultraviolet initiator to be used in the present second step may include those as illustrated in the first step. It is preferred that the initiator is mixed in an amount of 0.002˜2 parts by weight, which is not specifically limited, relative to 100 parts by weight of pre-polymer.
Said high absorbent substance includes a liquid phase and a powder phase, and is preferably selected from those having an excellent absorbency for mucinoid exudates. It is preferred to use one or two or more mixture selected from the group consisting of, for example, polyacrylic acid salt, polymethacrylic acid salt, polyacrylamide, cellulose, carboxymethylcellulose, hydroxyethylcellulose, pectin, guar gum, sodium alginate, chitin, chitosane, gellatin, starch, xanthane gum and karaya gum. Such high absorbent substance is, preferably, mixed in a range of 0.2˜100 parts by weight relative to 100 parts by weight of pre-polymer. If the high absorbent substance is contained too little as much as less than 0.2 parts by weight, it is difficult to exhibit the desired absorbency in the present invention. If it is contained too large as much as in excess of 100 parts by weight, the residue may be remained on the wound.
Said complex essentially contains a pre-polymer, an ultraviolet initiator and a high absorbent substance as described above, but may further comprise a cross linking agent for improving a shearing stress and cohesion. Said cross linking agent may be mixed in an amount of 0.0001˜2 parts by weight relative to 100 parts by weight of pre-polymer.
In addition, said complex further comprises additives useful in treating the wound such as humectants, wound healing accelerators, antibacterial agents, and cell growth factors.
For said humectant and wound healing accelerator, hyaluronic acid, keratan, collagen, dermatan sulfate, heparin, heparin sulfate, sodium alginate, sodium carboxymethylcellulose, chondrotin sulfate, 3-aminopropyldihydrogen phosphate or oligopolysaccharide thereof, and the like may be employed alone or in a mixture thereof. For said antibacterial agent, gluconate chlorohexidin, acetate chlorohexidin, hydrochloride chlorohexidin, silver sulferdiazine, povidone iodine, benzalkonium chloride, furagin, idocaine, hexachlorophene, chlorotetracycline, neomycin, penicilline, gentamycin, acrinol, and silver (Ag) compounds, and the like may be used. In addition, for said cell growth factor, a platelet-derived growth factor (PDGF), a transforming growth factor (TGF-β), a epidermal cell-derived growth factor (EGF), a fibroblast growth factor (FGF), and the like may be employed alone or in a mixture thereof. Each additive may be mixed in an amount of 0.001˜0.5 parts by weight relative to 100 parts by weight of pre-polymer.
In addition, the complex may be transparent or semitransparent. Preferably, it is constructed to be transparent, for easy wound observation. In addition, the complex may include a pigment (preferably, skin color pigment). If possible, it may be used in a trace amount, among the amounts not interfering wound observation.
After mixing and preparing the complex with a composition above, eliminating the dissolved oxygen in said complex is preferably performed for the more efficient polymerization to be proceeded in the third step below (referred to Step 2-1). Specifically, the dissolved oxygen, which may be present in the complex, can inhibit the polymerization reaction to be proceeded in the third step. In case of using oxygen for completing the reaction of pre-polymer (for example, in case of practicing Step 1-1), a large quantity of the dissolved oxygen may be present in the complex. If possible, it is preferred to practice Step 2-1 in which the dissolved oxygen is eliminated, before the third step. The dissolved oxygen may be easily eliminated by inhaling an inert gas such as nitrogen, argon, and helium in the complex.
[Third Step]
The third step comprises coating the object with the complex, and then irradiating on the complex with ultraviolet rays to polymerize a pre-polymer. Specifically, the pre-polymer in the complex is polymerized in a state coated on the object to form a hydrocolloid type of acryl polymer. After coating the object for coating process with the complex, a clear film is covered on the coated complex, to make an inert gas atmosphere, followed by irradiating on the film with ultraviolet rays to be subjected to the polymerization.
As above, the pre-polymer is polymerized together with the high absorbent substance by the polymerization via ultraviolet irradiation in the third step, with forming interpenetrated polymer networks (IPNs). Thus, the high absorbent substance used for an excellent absorbency is not degraded, even if it absorbs exudates, and no residue is remained.
In addition, the ultraviolet irradiation intensity in the third step is, preferably, as low as in a range of 0.01 mW/cm2˜5.0 mW/cm2. Such ultraviolet irradiation intensity improves adhesiveness, and moreover the increased molecular weight improves heat resistance. If the ultraviolet irradiation intensity is too low as much as less than 0.01 mW/cm2, the pre-polymer and the high absorbent substance cannot form a good networks. If the ultraviolet irradiation intensity is too high as much as in excess of 5.0 mW/cm2, a sticky property may be lowered and self-adhesiveness also dropped. The ultraviolet irradiation time is not specifically limited, but may be for 1˜30 minutes at the irradiation intensity above.
The thus prepared hydrocolloid of the present invention is usefully applied to skin, particularly, wounds. Specifically, the hydrocolloid may be usefully used in a fixing adhesive tape for fixing medical apparatuses or bandages on skin, and preferably, wound dressings.
As shown in
The size or form of such sheet is not restricted. For example, the sheet may be provided as cut from the prepared sheet above in a certain size for convenient use, or may be provided in a form of roll that users can directly cut it in a size fitted for a certain use. In addition, the sheet may have a structure that a release paper is bonded thereto. The release paper is positioned on the opposite side to the bonding side of substrate (20) and removed when the sheet is adhered to the skin (wound).
As used herein, the term “an object for coating process” includes those provided with surfaces that the complex can be coated. The object for coating process may be selected from the group consisting of the substrate (20) or the release paper, and a glass substrate, a metal substrate, a plastic substrate, and the like. Preferably, the object has a releasing property.
Specific experimental example and comparative examples are explained below. These examples are provided to illustrate the present invention in detail, and are not intended to restrict the technical scope of the present invention.
<First Step: Preparation Example of Pre-Polymer>
Under nitrogen atmosphere, 95 g of 2-ethylhexyl acrylate as an acryl monomer, 5 g of acrylic acid, and 0.2 g of Irgacure-184 (available from Ciba-Geigy AG, Swiss) as an ultraviolet initiator were added to a glass reactor, and the mixture was sufficiently stirred. Ultraviolet rays were irradiated on the reactant at an irradiation intensity of 1.0 mW/cm2 for 30 seconds, using an ultraviolet lamp (Black light lamp) and then subjected to the reaction. When the temperature of the reactant was raised to 10° C., the reaction was terminated by blowing oxygen in the reactor to obtain a pre-polymer. The obtained pre-polymer had a viscosity of 2,000 cps at 25° C.
<Second Step: Preparation Example of Complex>
Under nitrogen atmosphere, 0.4 g of Irgacure-184 (available from Ciba-Geigy AG, Swiss) as an ultraviolet initiator, and 7 g of carboxymethylcellulose (KDA 6M15, available from Koje Co., Korea) and 15 g of polyacrylic acid salt (HS-1500, available from Songwon Industrial Co, Ltd., Korea) as high absorbent substances were added, in addition to 100 g of the pre-polymer obtained in Preparation Example of First step above, to a mixer and the mixture was stirred and dispersed for 30 minutes to obtain a viscous complex. The obtained complex had a viscosity of 20,000 cps at 25° C.
<Third Step: Examples 1-12>
The complex prepared in Preparation Example of Second step above was coated in a thickness of 500 μm on a silicon-coated release paper with a knife-coater apparatus, followed by covering with PET film thereon. Ultraviolet rays were irradiated on each reactant at an irradiation intensity set forth in Table 1 below for 20 minutes, using an ultraviolet lamp (Black light lamp) and then sufficiently subjected to the reaction. After each covered PET film was peeled off, each 25 μm polyurethane film was laminated thereon to prepare self-adhesive sheet specimens.
Physical properties of the specimens prepared above were measured by the methods illustrated below, and the results were represented in Table 1 below.
{circle around (1)} 180° Peeling Adhesive Strength Measurement
Measurement of adhesive strength was tested according to JIS Z 0237, using a tensile test machine (Universal Test Machine, Tinus Olsen Korea). Specifically, the longitudinal edge of stainless steel test plate was met with that of a specimen set the adhesive side downward to the test plate. Then, the test plate was positioned on the longitudinal center of specimen and a paper was adhered to the adhesive side of about 125 mm part in the remaining specimen. Next, the specimen was compressed by running once a roller on the specimen at a speed of about 300 mm/min. After 20 minutes or so, the completely compressed specimen was peeled by about 25 mm, and peeled at a tensile speed of 300 mm/min. Each average load value between the time of peeling by 20 mm from the start of peeling and that of peeling by 80 mm was calculated by an integrator, and the value was used as a measurement of adhesive strength.
{circle around (2)} Measurement of Absorbency
The prepared specimen was cut in a size of 2 by 2 cm and its initial weight (W1) was measured. The specimen was added to distilled water, its weight (W2) was measured after 48 h. The degree of absorbency was calculated by the following formula:
Absorbency (%)=(W2−W1)/W1×100
{circle around (3)} Measurement of Retention
The term “retention” means the ability that the specimen is not degraded by a physiological saline. The measurement of retention is performed by measuring the weight percentage of specimen maintained after exposing to the physiological saline under the conditions set forth below. 100% of retention means that when the specimen is adhered to a wound and then exchanged, no residue is remained on the wound site.
First, the specimen was cut in a diameter of 2.54 cm, and its initial weight (W1) was measured and recorded. Next, the specimen was soaked in a physiological saline and stirred for 18 h. The specimen was taken out, and dried in a thermohygrostat of temperature 50° C. x50% RH for 72 h. The weight (Wf) of specimen was measured. The degree of retention (%) was calculated by the following formula:
Retention (%)=(Wf/Wi)×100
A Comfeel product from Coloplast Corp. (US) was used as a specimen in this comparative example. This product was prepared by a method described in U.S. Pat. No. 4,231,369. The physical properties of the specimen were evaluated by the same method as the Examples above, and the results were represented in Table 1 below.
A Duoderm product from Convatec (JS) was used as a specimen in this comparative example. This product was prepared by a method described in U.S. Pat. No. 4,551,490. The physical properties of the specimen were evaluated by the same method as the Examples above, and the results were represented in Table 1 below.
As can be seen from the Table 1, the sheets (Examples 1˜12) applied by the hydrocolloids according to the present invention has a very excellent absorbency and an excellent adhesive strength, without adding low molecular weight material as a tackifier, compared to existing products on the market (Comparative Example 1, 2). It can be seen from the results of Examples that the adhesive strength is easily regulated by the irradiation intensity of ultraviolet rays.
In addition, the retentions of Comparative Examples 1 and 2 are 78% and 91%, respectively, but all the retentions of Examples in the present invention are 100%. Such excellent retention is because the interpenetrated polymer networks (IPNs) are formed from the aryl polymers and the high absorbent substances. This fact means that even though the sheet absorbs exudates, it is not degraded, so that no residue is remained.
The present invention has an effect that a hydrocolloid may be easily prepared without using a large quantity of solvent or other additives. In addition, the present invention has effects that a hydrocolloid prepared according to the present invention has an excellent absorbency as well as self-adhesiveness, is not allowed to leave residues upon being removed from the skin (wound) and has low skin stimuli due to no use of low molecular weight tackifier.
| Number | Date | Country | Kind |
|---|---|---|---|
| 1020060050396 | Jun 2006 | KR | national |
