Claims
- 1. A method for preserving a deoxygenated hemoglobin blood substitute comprising maintaining the deoxygenated hemoglobin blood substitute in an oxygen barrier film overwrap that includes a foil laminate material having a thickness of between about 0.0001 and about 0.001 inches, said oxygen barrier film overwrap having an oxygen permeability of less than about 1.0 cc per 100 square inches per 24 hours per atmosphere at room temperature.
- 2. The method of claim 1 wherein the foil laminate material includes an aluminum foil laminate.
- 3. The method of claim 1 wherein the foil laminate material further comprises a polymer layer.
- 4. The method of claim 1 wherein the oxygen barrier film overwrap comprises two sheets of the foil laminate material continuously bonded at a perimeter of the oxygen barrier film overwrap.
- 5. The method of claim 4 wherein the two sheets of the foil laminate material are bonded by a polyester adhesive.
- 6. The method of claim 3 wherein the polymer layer is oxygen impermeable.
- 7. The method of claim 1 wherein the oxygen barrier film overwrap further includes glass.
- 8. The method of claim 1 wherein the hemoglobin blood substitute is maintained under a nitrogen, argon or helium atmosphere.
- 9. A preserved deoxygenated hemoglobin blood substitute, comprising:
- a) a deoxygenated hemoglobin blood substitute; and
- b) an oxygen barrier film overwrap that includes a foil laminate material having a thickness of between about 0.0001 and about 0.001 inches, said oxygen barrier film overwrap having an oxygen permeability of less than about 1.0 cc per 100 square inches per 24 hours per atmosphere at room temperature, within which the deoxygenated hemoglobin blood substitute is sealed, thereby preserving the deoxygenated hemoglobin blood substitute in an environment that is substantially free of oxygen.
- 10. The preserved deoxygenated blood substitute of claim 9 wherein the foil laminate material includes an aluminum foil laminate.
- 11. The method of claim 9 wherein the foil laminate material further includes a polymer layer.
- 12. The preserved deoxygenated blood substitute of claim 9 wherein the oxygen barrier film overwrap includes two sheets of the foil laminate material continuously bonded at a perimeter of the foil laminate material.
- 13. The preserved deoxygenated blood substitute of claim 12 wherein the two sheets of the foil laminate material are bonded by a polyester adhesive.
- 14. The preserved deoxygenated blood substitute of claim 11 wherein the polymer layer is oxygen impermeable.
- 15. The preserved deoxygenated blood substitute of claim 9 wherein the oxygen barrier film overwrap further includes glass.
RELATED APPLICATIONS
This application is a Continuation-in-Part of U.S. patent application Ser. No. 08/458,916, filed on Jun. 2, 1995, entitled "METHOD FOR PRODUCING ULTRAPURE STABLE POLYMERIZED HEMOGLOBIN BLOOD-SUBSTITUTE," by Carl W. Rausch, et al. (attorney docket No. BP94-03A), which is a Continuation of U.S. patent application Ser. No. 08/409,337, filed Mar. 23, 1995, the teachings of which are incorporated herein by reference.
US Referenced Citations (11)
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO8912456 |
Dec 1989 |
WOX |
Continuations (1)
|
Number |
Date |
Country |
Parent |
409337 |
Mar 1995 |
|
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
458916 |
Jun 1995 |
|