Claims
- 1. A method of screening a subject for mitochondrial dysfunction, comprising detecting the presence or absence of single nucleotide changes in a hypervariable region of the mitochondrial DNA of said subject, the presence of such changes indicating that said subject is afflicted with or at risk of developing mitochondrial dysfunction.
- 2. The method according to claim 1, wherein said subject is a human subject.
- 3. The method according to claim 1, wherein said hypervariable region consists of hypervariable region HV1 and HV2.
- 4. The method according to claim 1, wherein said hypervariable region consists of hypervariable region HV1.
- 5. The method according to claim 1, wherein said single nucleotide change is selected from the group consisting of:
16168 C-T, 16093 T-C, 16481 C-T, 16176 C-T, 16388 A-G, 16259 C-T, 16278 C-T, 16288 T-C, 16186 C-T, 16215 A-T, and 16285 C-T.
- 6. The method according to claim 1, wherein said single nucleotide change is 16168 C-T.
- 7. The method according to claim 1, wherein said single nucleotide change is 16093 T-C.
- 8. The method according to claim 1, wherein said single nucleotide change is 16481 C-T.
- 9. The method according to claim 1, wherein said single nucleotide change is 16176 C-T.
- 10. The method according to claim 1, wherein said single nucleotide change is 16388 A-G.
- 11. The method according to claim 1, wherein said single nucleotide change is 16259 C-T.
- 12. The method according to claim 1, wherein said single nucleotide change is 16278 C-T.
- 13. The method according to claim 1, wherein said single nucleotide change is 16288 T-C.
- 14. The method according to claim 1, wherein said single nucleotide change is 16186 C-T.
- 15. The method according to claim 1, wherein said single nucleotide change is 16215 A-T.
- 16. The method according to claim 1, wherein said single nucleotide change is 16285 C-T.
RELATED APPLICATIONS
[0001] This application claims the benefit of U.S. Provisional Application Serial No. 60/184,379, filed Feb. 23, 2000, the disclosure of which is incorporated by reference herein in its entirety.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60184379 |
Feb 2000 |
US |