FIELD OF THE INVENTION
The invention relates to genetic methods for identifying risk of breast cancer and treatments that specifically target the disease.
BACKGROUND
Breast cancer is the third most common cancer, and the most common cancer in women, as well as a cause of disability, psychological trauma, and economic loss. Breast cancer is the second most common cause of cancer death in women in the United States, in particular for women between the ages of 15 and 54, and the leading cause of cancer-related death (Forbes, Seminars in Oncology, vol. 24 (1), Suppl 1, 1997: pp. S1-20-S1-35). Indirect effects of the disease also contribute to the mortality from breast cancer including consequences of advanced disease, such as metastases to the bone or brain. Complications arising from bone marrow suppression, radiation fibrosis and neutropenic sepsis, collateral effects from therapeutic interventions, such as surgery, radiation, chemotherapy, or bone marrow transplantation-also contribute to the morbidity and mortality from this disease.
While the pathogenesis of breast cancer is unclear, transformation of normal breast epithelium to a malignant phenotype may be the result of genetic factors, especially in women under thirty (Miki, et al., Science, 266: 66-71 (1994)). However, it is likely that other, non-genetic factors also have a significant effect on the etiology of the disease. Regardless of its origin, breast cancer morbidity increases significantly if it is not detected early in its progression. Thus, considerable efforts have focused on the elucidation of early cellular events surrounding transformation in breast tissue. Such efforts have led to the identification of several potential breast cancer markers. For example, alleles of the BRCA1 and BRCA2 genes have been linked to hereditary and early-onset breast cancer (Wooster, et al., Science, 265: 2088-2090 (1994)). However, BRCA1 is limited as a cancer marker because BRCA1 mutations fail to account for the majority of breast cancers (Ford, et al., British J. Cancer, 72: 805-812 (1995)). Similarly, the BRCA2 gene, which has been linked to forms of hereditary breast cancer, accounts for only a small portion of total breast cancer cases.
SUMMARY
It has been discovered that certain polymorphic variations in human genomic DNA are associated with the occurrence of breast cancer. In particular, polymorphic variants in loci containing ICAM, MAPK10, KIAA0861, NUMA1/FLJ20625/LOC220074 (hereafter referred to as “NUMA1”), HT014/LOC148902/LYPLA2/GALE (hereafter refered to as “GALE”), DPF3 and LOC145197 regions in human genomic DNA have been associated with risk of breast cancer.
Thus, featured herein are methods for identifying a subject at risk of breast cancer and/or a risk of breast cancer in a subject, which comprises detecting the presence or absence of one or more polymorphic variations accociated with breast cancer in genomic regions described herein in a human nucleic acid sample. In an embodiment, two or more polymorphic variations are detected in two or more regions selected from the group consisting of ICAM, MAK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197. In certain embodiments, 3 or more, or 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 or more polymorphic variants are detected. In specific embodiments, the group of polymorphic variants detected comprise or consist of polymorphic variants in ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and/or LOC145197, such as position 44247 in SEQ ID NO: 1 (ICAM), position 36424 in SEQ ID NO: 2 (MAPK10), position 48563 in SEQ ID NO: 3 (KIAA0861), position 49002 in SEQ ID NO: 4 (NUMA1) and position 174 in SEQ ID NO: 5 (GALE), for example.
Also featured are nucleic acids that include one or more polymorphic variations associated with the occurrence of breast cancer, as well as polypeptides encoded by these nucleic acids. Further, provided is a method for identifying a subject at risk of breast cancer and then prescribing to the subject a breast cancer detection procedure, prevention procedure and/or a treatment procedure. In addition, provided are methods for identifying candidate therapeutic molecules for treating breast cancer and related disorders, as well as methods for treating breast cancer in a subject by diagnosing breast cancer in the subject and treating the subject with a suitable treatment, such as administering a therapeutic molecule.
Also provided are compositions comprising a breast cancer cell and/or ICAM, AAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid with a RNAi, siRNA, antisense DNA or RNA, or ribozyme nucleic acid designed from a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence. In an embodiment, the nucleic acid is designed from a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence that includes one or more breast cancer associated polymorphic variations, and in some instances, specifically interacts with such a nucleotide sequence. Further, provided are arrays of nucleic acids bound to a solid surface, in which one or more nucleic acid molecules of the array have a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence, or a fragment or substantially identical nucleic acid thereof, or a complementary nucleic acid of the foregoing. Featured also are compositions comprising a breast cancer cell and/or a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide, with an antibody that specifically binds to the polypeptide. In an embodiment, the antibody specifically binds to an epitope in the polypeptide that includes a non-synonymous amino acid modification associated with breast cancer (e.g., results in an amino acid substitution in the encoded polypeptide associated with breast cancer). In certain embodiments, the antibody specifically binds to an epitope that comprises a proline at amino acid position 352, an alanine at amino acid position 348, or a glycine at amino acid position 241 in an ICAM5 polypeptide.
BRIEF DESCRIPTION OF THE FIGURES
FIGS. 1A-1G show proximal SNPs in ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 regions of genomic DNA, respectively. The position of each SNP on the chromosome is shown on the x-axis and the y-axis provides the negative logarithm of the p-value comparing the estimated allele to that of the control group. Also shown in the figure are exons and introns of the genes in the approximate chromosomal positions.
FIGS. 2A-2D show results of an odds-ratio meta analysis for ICAM, MAPK10, KIkA0861 NUMA1 regions.
FIG. 3 shows effects of ICAM-directed siRNA on cancer cell proliferation.
DETAILED DESCRIPTION
It has been discovered that polymorphic variations in the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 regions described herein are associated with an increased risk of breast cancer.
All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. The proteins are members of the intercellular adhesion molecule (ICAM) family. The gene ICAM1 (intercellular adhesion molecule-1) is also known as human rhinovirus receptor, BB2, CD54. and cell surface glycoprotein P3.58. ICAM1 has been mapped to chromosomal position 19p13.3-p13.2. ICAM1 (CD54) typically is expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a/CD 18, or CD11b/CD18. ICAM1 is also exploited by Rhinovirus as a receptor.
The gene ICAM4 (intercellular adhesion molecule 4) is also known as the Landsteiner-Wiener blood group or LW. ICAM4 has been mapped to 19p13.2-cen. The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. A glutamine to arginine polymorphism in this protein is responsible for the Landsteiner-Wiener blood group system (GLN=WB(A); ARG=WB(B). This gene consists of 3 exons and alternative splicing generates 2 transcript variants.
The gene ICAM5 (intercellular adhesion molecule 5) is also known as telencephalin. ICAM5 has been mapped to 19p13.2. The protein encoded by the gene is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases.
The gene MAPK10 also is known as JNK3, JNK3A, PRKM10, p493F12, FLJ12099, p54bSAPK MAP kinase, c-Jun kinase 3, JNK3 alpha protein kinase, c-Jun N-terminal kinase 3, stress activated protein kinase JNK3, stress activated protein kinase beta. MAPK10 has been mapped to chromosomal position 4q22.1-q23. The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
The gene KIAA0861 is a Rho family guanine-nucleotide exchange factor. KIAA0861 has been mapped to chromosomal position 3q27.3. KIAA0861 is a Rho family nucleotide exchange factor homolog that modulates the activity of Rho family GTPases, which control numerous cell functions, including cell growth, adhesion, movement and shape. RhoC GTPase is overexpressed in invasive (inflammatory) breast cancers.
The gene FLJ20625 has been mapped to chromosomal position 11q13.3. The gene encoding LOC220074 also is known as Hypothetical 55.1 kDa protein F09G8.5 in chromosome III and has been mapped to chromosomal position 11q13.3.
The gene HT014 has been mapped to chromosomal position 1p36.11. The gene LYPLA2 (lysophospholipase II) also is known as APT-2, DJ886K2.4 and acyl-protein thioesterase and has been mapped to chromosomal position 1p36.12-p35.1. Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.
The gene GALE (galactose-4-epimerase, UDP-) also is known as galactowaldenase UDP galactose4-epimerase and has been mapped to chromosomal position 1 p36-p35. This gene encodes UDP-galactose-4-epimerase which catalyzes 2 distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine for necessary precursor for the synthesis of glycoproteins and glycolipids. The missense mutations in the GALE gene result in the epimerase-deficiency galactosemia.
The gene DPF3 (D4, zinc and double PHD fingers, family 3) also is known as CERD4, cer-d4, FLJ14079, and 2810403B03Rik. DPF3 is a Rho family guanine-nucleotide exchange factor. DPF3 has been mapped to chromosomal position 14q24.3-q31.1.
Breast Cancer and Sample Selection
Breast cancer is typically described as the uncontrolled growth of malignant breast tissue. Breast cancers arise most commonly in the lining of the milk ducts of the breast (ductal carcinoma), or in the lobules where breast milk is produced (lobular carcinoma). Other forms of breast cancer include Inflammatory Breast Cancer and Recurrent Breast Cancer. Inflammatory breast cancer is a rare, but very serious, aggressive type of breast cancer. The breast may look red and feel warm with ridges, welts, or hives on the breast; or the skin may look wrinkled. It is sometimes misdiagnosed as a simple infection. Recurrent disease means that the cancer has come back after it has been treated. It may come back in the breast, in the soft tissues of the chest (the chest wall), or in another part of the body.
As used herein, the term “breast cancer” refers to a condition characterized by anomalous rapid proliferation of abnormal cells in one or both breasts of a subject. The abnormal cells often are referred to as “neoplastic cells,” which are transformed cells that can form a solid tumor. The term “tumor” refers to an abnormal mass or population of cells (i.e. two or more cells) that result from excessive or abnormal cell division, whether malignant or benign, and pre-cancerous and cancerous cells. Malignant tumors are distinguished from benign growths or tumors in that, in addition to uncontrolled cellular proliferation, they can invade surrounding tissues and can metastasize. In breast cancer, neoplastic cells may be identified in one or both breasts only and not in another tissue or organ, in one or both breasts and one or more adjacent tissues or organs (e.g. lymph node), or in a breast and one or more non-adjacent tissues or organs to which the breast cancer cells have metastasized.
The term “invasion” as used herein refers to the spread of cancerous cells to adjacent surrounding tissues. The term “invasion” often is used synonymously with the term “metastasis,” which as used herein refers to a process in which cancer cells travel from one organ or tissue to another non-adjacent organ or tissue. Cancer cells in the breast(s) can spread to tissues and organs of a subject, and conversely, cancer cells from other organs or tissue can invade or metastasize to a breast. Cancerous cells from the breast(s) may invade or metastasize to any other organ or tissue of the body. Breast cancer cells often invade lymph node cells and/or metastasize to the liver, brain and/or bone and spread cancer in these tissues and organs. Breast cancers can spread to other organs and tissues and cause lung cancer, prostate cancer, colon cancer, ovarian cancer, cervical cancer, gastrointestinal cancer, pancreatic cancer, glioblastoma, bladder cancer, hepatoma, colorectal cancer, uterine cervical cancer, endometrial carcinoma, salivary gland carcinoma, kidney cancer, vulval cancer, thyroid cancer, hepatic carcinoma, skin cancer, melanoma, ovarian cancer, neuroblastoma, myeloma, various types of head and neck cancer, acute lymphoblastic leukemia, acute myeloid leukemia, Ewing sarcoma and peripheral neuroepithelioma, and other carcinomas, lymphomas, blastomas, sarcomas, and leukemias.
Breast cancers arise most commonly in the lining of the milk ducts of the breast (ductal carcinoma), or in the lobules where breast milk is produced (lobular carcinoma). Other forms of breast cancer include Inflammatory Breast Cancer and Recurrent Breast Cancer. Inflammatory Breast Cancer is a rare, but very serious, aggressive type of breast cancer. The breast may look red and feel warm with ridges, welts, or hives on the breast; or the skin may look wrinkled. It is sometimes misdiagnosed as a simple infection. Recurrent disease means that the cancer has come back after it has been treated. It may come back in the breast, in the soft tissues of the chest (the chest wall), or in another part of the body. As used herein, the term “breast cancer” may include both Inflammatory Breast Cancer and Recurrent Breast Cancer.
In an effort to detect breast cancer as early as possible, regular physical exams and screening mammograms often are prescribed and conducted. A diagnostic mammogram often is performed to evaluate a breast complaint or abnormality detected by physical exam or routine screening mammography. If an abnormality seen with diagnostic mammography is suspicious, additional breast imaging (with exams such as ultrasound) or a biopsy may be ordered. A biopsy followed by pathological (microscopic) analysis is a definitive way to determine whether a subject has breast cancer. Excised breast cancer samples often are subjected to the following analyses: diagnosis of the breast tumor and confirmation of its malignancy; maximum tumor thickness; assessment of completeness of excision of invasive and in situ components and microscopic measurements of the shortest extent of clearance; level of invasion; presence and extent of regression; presence and extent of ulceration; histological type and special variants; pre-existing lesion; mitotic rate; vascular invasion; neurotropism; cell type; tumor lymphocyte infiltration; and growth phase.
The stage of a breast cancer can be classified as a range of stages from Stage 0 to Stage IV based on its size and the extent to which it has spread. The following table summarizes the stages:
TABLE A
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Metastasis
StageTumor SizeLymph Node Involvement(Spread)
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ILess than 2 cmNoNo
IIBetween 2-5 cmNo or in same side of breastNo
IIIMore than 5 cmYes, on same side of breastNo
IVNot applicableNot applicableYes
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Stage 0 cancer is a contained cancer that has not spread beyond the breast ductal system. Fifteen to twenty percent of breast cancers detected by clinical examinations or testing are in Stage 0 (the earliest form of breast cancer). Two types of Stage 0 cancer are lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS). LCIS indicates high risk for breast cancer. Many physicians do not classify LCIS as a malignancy and often encounter LCIS by chance on breast biopsy while investigating another area of concern. While the microscopic features of LCIS are abnormal and are similar to malignancy, LCIS does not behave as a cancer (and therefore is not treated as a cancer). LCIS is merely a marker for a significantly increased risk of cancer anywhere in the breast. However, bilateral simple mastectomy may be occasionally performed if LCIS patients have a strong family history of breast cancer. In DCIS the cancer cells are confined to milk ducts in the breast and have not spread into the fatty breast tissue or to any other part of the body (such as the lymph nodes). DCIS may be detected on mammogram as tiny specks of calcium (known as microcalcifications) 80% of the time. Less commonly DCIS can present itself as a mass with calcifications (15% of the time); and even less likely as a mass without calcifications (<5% of the time). A breast biopsy is used to confirm DCIS. A standard DCIS treatment is breast-conserving therapy (BCT), which is lumpectomy followed by radiation treatment or mastectomy. To date, DCIS patients have chosen equally among lumpectomy and mastectomy as their treatment option, though specific cases may sometimes favor lumpectomy over mastectomy or vice versa.
In Stage I, the primary cancer is 2 cm or less in diameter and has not spread to the lymph nodes. In Stage IIA, the primary tumor is between 2 and 5 cm in diameter and has not spread to the lymph nodes. In Stage IIIB, the primary tumor is between 2 and 5 cm in diameter and has spread to the axillary (underarm) lymph nodes; or the primary tumor is over 5 cm and has not spread to the lymph nodes. In Stage 111A, the primary breast cancer of any kind that has spread to the axillary (underarm) lymph nodes and to axillary tissues. In Stage IIIB, the primary breast cancer is any size, has attached itself to the chest wall, and has spread to the pectoral (chest) lymph nodes. In Stage IV, the primary cancer has spread out of the breast to other parts of the body (such as bone, lung, liver, brain). The treatment of Stage IV breast cancer focuses on extending survival time and relieving symptoms.
Based in part upon selection criteria set forth above, individuals having breast cancer can be selected for genetic studies. Also, individuals having no history of cancer or breast cancer often are selected for genetic studies. Other selection criteria can include: a tissue or fluid sample is derived from an individual characterized as Caucasian; the sample was derived from an individual of German paternal and maternal descent; the database included relevant phenotype information for the individual; case samples were derived from individuals diagnosed with breast cancer; control samples were derived from individuals free of cancer and no family history of breast cancer; and sufficient genomic DNA was extracted from each blood sample for all allelotyping and genotyping reactions performed during the study. Phenotype information included pre- or post-menopausal, familial predisposition, country or origin of mother and father, diagnosis with breast cancer (date of primary diagnosis, age of individual as of primary diagnosis, grade or stage of development, occurrence of metastases, e.g., lymph node metastases, organ metastases), condition of body tissue (skin tissue, breast tissue, ovary tissue, peritoneum tissue and myometrium), method of treatment (surgery, chemotherapy, hormone therapy, radiation therapy).
Provided herein is a set of blood samples and a set of corresponding nucleic acid samples isolated from the blood samples, where the blood samples are donated from individuals diagnosed with breast cancer. The sample set often includes blood samples or nucleic acid samples from 100 or more, 150 or more, or 200 or more individuals having breast cancer, and sometimes from 250 or more, 300 or more, 400 or more, or 500 or more individuals. The individuals can have parents from any place of origin, and in an embodiment, the set of samples are extracted from individuals of German paternal and German maternal ancestry. The samples in each set may be selected based upon five or more criteria and/or phenotypes set forth above.
Polymorphic Variants Associated with Breast Cancer
A genetic analysis provided herein linked breast cancer with polymorphic variants in the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 regions of the human genome disclosed herein. As used herein, the term “polymorphic site” refers to a region in a nucleic acid at which two or more alternative nucleotide sequences are observed in a significant number of nucleic acid samples from a population of individuals. A polymorphic site may be a nucleotide sequence of two or more nucleotides, an inserted nucleotide or nucleotide sequence, a deleted nucleotide or nucleotide sequence, or a microsatellite, for example. A polymorphic site that is two or more nucleotides in length may be 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or more, 20 or more, 30 or more, 50 or more, 75 or more, 100 or more, 500 or more, or about 1000 nucleotides in length, where all or some of the nucleotide sequences differ within the region. A polymorphic site is often one nucleotide in length, which is referred to herein as a “single nucleotide polymorphism” or a “SNP.”
Where there are two, three, or four alternative nucleotide sequences at a polymorphic site, each nucleotide sequence is referred to as a “polymorphic variant” or “nucleic acid variant.” Where two polymorphic variants exist, for example, the polymorphic variant represented in a minority of samples from a population is sometimes referred to as a “minor allele” and the polymorphic variant that is more prevalently represented is sometimes referred to as a “major allele.” Many organisms possess a copy of each chromosome (e.g., humans), and those individuals who possess two major alleles or two minor alleles are often referred to as being “homozygous” with respect to the polymorphism, and those individuals who possess one major allele and one minor allele are normally referred to as being “heterozygous” with respect to the polymorphism. Individuals who are homozygous with respect to one allele are sometimes predisposed to a different phenotype as compared to individuals who are heterozygous or homozygous with respect to another allele.
Furthermore, a genotype or polymorphic variant may be expressed in terms of a “haplotype,” which as used herein refers to two or more polymorphic variants occurring within genomic DNA in a group of individuals within a population. For example, two SNPs may exist within a gene where each SNP position includes a cytosine variation and an adenine variation. Certain individuals in a population may carry one allele (heterozygous) or two alleles (homozygous) having the gene with a cytosine at each SNP position. As the two cytosines corresponding to each SNP in the gene travel together on one or both alleles in these individuals, the individuals can be characterized as having a cytosine/cytosine haplotype with respect to the two SNPs in the gene.
As used herein, the term “phenotype” refers to a trait which can be compared between individuals, such as presence or absence of a condition, a visually observable difference in appearance between individuals, metabolic variations, physiological variations, variations in the function of biological molecules, and the like. An example of a phenotype is occurrence of breast cancer.
Researchers sometimes report a polymorphic variant in a database without determining whether the variant is represented in a significant fraction of a population. Because a subset of these reported polymorphic variants are not represented in a statistically significant portion of the population, some of them are sequencing errors and/or not biologically relevant. Thus, it is often not known whether a reported polymorphic variant is statistically significant or biologically relevant until the presence of the variant is detected in a population of individuals and the frequency of the variant is determined. Methods for detecting a polymorphic variant in a population are described herein, specifically in Example 2. A polymorphic variant is statistically significant and often biologically relevant if it is represented in 5% or more of a population, sometimes 10% or more, 15% or more, or 20% or more of a population, and often 25% or more, 30% or more, 35% or more, 40% or more, 45% or more, or 50% or more of a population.
A polymorphic variant may be detected on either or both strands of a double-stranded nucleic acid. For example, a thymine at a particular position in SEQ ID NO: 1 can be reported as an adenine from the complementary strand. Also, a polymorphic variant may be located within an intron or exon of a gene or within a portion of a regulatory region such as a promoter, a 5′ untranslated region (UTR), a 3′ UTR, and in DNA (e.g., genomic DNA (gDNA) and complementary DNA (cDNA)), RNA (e.g., mRNA, tRNA, and rRNA), or a polypeptide. Polymorphic variations may or may not result in detectable differences in gene expression, polypeptide structure, or polypeptide function.
In the genetic analysis that associated breast cancer with the polymorphic variants described hereafter, samples from individuals having breast cancer and individuals not having cancer were allelotyped and genotyped. The term “genotyped” as used herein refers to a process for determining a genotype of one or more individuals, where a “genotype” is a representation of one or more polymorphic variants in a population. Genotypes may be expressed in terms of a “haplotype,” which as used herein refers to two or more polymorphic variants occurring within genomic DNA in a group of individuals within a population. For example, two SNPs may exist within a gene where each SNP position includes a cytosine variation and an adenine variation. Certain individuals in a population may carry one allele (heterozygous) or two alleles (homozygous) having the gene with a cytosine at each SNP position. As the two cytosines corresponding to each SNP in the gene travel together on one or both alleles in these individuals, the individuals can be characterized as having a cytosine/cytosine haplotype with respect to the two SNPs in the gene.
It was determined that polymorphic variations associated with an increased risk of breast cancer existed in ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 nucleotide sequences. Polymorphic variants in and around the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 loci were tested for association with breast cancer. In the ICAM locus, these included polymorphic variants at positions selected from the group consisting of rs2884487, rs2358580, rs2304236, rs1059840, rs1059843, rs11115, rs1059849, rs1059855, rs5030386, rs5030339, rs5030387, rs5030388, rs1799766, rs5030389, rs5490, rs11575070, rs5030340, rs5030390, rs5030391, rs3093035, rs11667983, rs5030341, rs5030342, rs5030343, rs5030344, rs5030347, rs5030348, rs5030349, rs5030350, rs5030351, rs5491, rs5030352, rs5030353, rs10420063, rs11879117, rs5030354, rs5030355, rs281428, rs5030358, rs5030359, rs5030392, rs5030393, rs5030360, rs5030394, rs281429, rs5030361, rs5030362, rs281430, rs281431, rs5030395, rs5827095, rs281432, rs5030364, rs5030365, rs5030368, rs5030369, rs3073809, rs2358581, rs7258215, rs5030371, rs5030372, rs281433, rs5030374, rs5030375, rs5030397, rs281434, rs12462944, rs5030398, rs5030378, rs12459133, rs5030399, rs5492, rs1800019, rs1799969, rs5493, rs5030381, rs5494, rs3093033, rs5495, rs1801714, rs2071441, rs5496, rs5497, rs5030382, rs5030400, rs2071440, rs5499, rs3093032, rs1057981, rs5500, rs5501, rs5030383, rs281436, rs923366, rs281437, rs3093030, rs5030384, rs5030385, rs3810159, rs281438, rs3093029, rs2735442, rs2569693, rs281439, rs281440, rs2569694, rs11575073, rs2569695, rs2075741, rs11575074, rs2569696, rs2735439, rs2569697, rs2075742, rs2569698, rs11669397, rs901886, rs885742, rs2569699, rs11549918, rs2569700, rs2228615, rs2569701, rs2569702, rs2735440, rs2569703, rs10418913, rs1056536, rs2569704, rs11673661, rs10402760, rs2569706, rs2569707, rs2436545, rs2436546, rs2916060, rs2916059, rs2916058, rs2569708, rs735747, rs885743, rs710845, rs2569709, rs2569710, rs2569711, rs2569712, rs12610026, rs4804129, rs12150978, rs439843, rs892188, rs2291473, rs281416, rs281417, rs882589, rs1048941, rs281418, rs430092, rs368835, rs2358583, rs378395, rs395782, rs1045384, rs281427, rs3745264, rs281426, rs281425, rs281424, rs281423, rs281422, rs281420, rs3745263, rs3745262, rs3745261, rs3181049, rs281412, rs3181048, rs2230399, rs2278442, rs3181047, rs3181046, rs2304237, rs281413, rs1058154, rs3176769, rs2304238, rs2304239, rs2304240, rs3176768, rs3176767, rs3176766, rs281414, rs281415, position 45003 of SEQ ID NO: 1, and position 47504 of SEQ ID NO: 1. Polymorphic variants at the following positions in particular were associated with an increased risk of breast cancer: rs11115, rs1059849, rs5030391, rs5030382, rs3093030, rs2569693, rs2075741, rs901886, rs11549918, rs2228615, rs2569702, rs2569703, rs10402760, rs710845, rs892188, and rs281426. At these positions in SEQ ID NO: 1, a cytosine at position 11942, an adenine at position 12054, a guanine at position 24037, an adenine at position 37083, a cytosine at position 38803, a cytosine at position 41304, a guanine at position 42498, a thymine at position 43531, a cytosine at position 44338, a guanine at position 44768, a thymine at position 45347, a cytosine at position 45627, a thymine at position 47265, a cytosine at position 48569, a cytosine at position 51193, a guanine at position 72451, in particular were associated with risk of breast cancer. Also, a proline at amino acid position 352 or an alanine at amino acid position 348 in SEQ ID NO: 15 were in particular associated with an increased risk of breast cancer.
In the MAPK10 locus, these included polymorphic variants at positions selected from the group consisting of rs2575681, rs2575680, rs2589505, rs2589504, rs2164538, rs2575679, rs10305, rs2869408, rs2904086, rs934648, rs2589511, rs2060589, rs2164537, rs2575678, rs2575677, rs2589510, rs2589509, rs2164536, rs2164535, rs1946734, rs2589525, rs2589523, rs3755970, rs2575675, rs1202, rs1201, rs2589516, rs2575674, rs2589515, rs3733367, rs958, rs2589506, rs1436524, rs2575672, rs2589518, rs3775164, rs2589514, rs3775166, rs3775167, rs3822035, rs3775168, rs3775169, rs2043650, rs2043649, rs3775170, rs1541998, rs2282599, rs2282598, rs2282597, rs3775171, rs3775172, rs3775173, rs3775174, rs1469870, rs1436522, rs1946733, rs983362, rs3755971, rs3822036, rs3775175, rs1436525, rs3822037, rs3775176, rs993593, rs1436527, rs1436529, rs3775180, rs3775181, rs3775182, rs3775183, rs3775184, rs733245, rs3775185, rs1561154, rs3775186, rs3775187, rs1010778, rs2282596, rs2282595, rs2118044, rs1469869, position 21751 of SEQ ID NO: 2, position 30965 of SEQ ID NO: 2, position 36838 of SEQ ID NO: 2, position 36889 of SEQ ID NO: 2, position 38639 of SEQ ID NO: 2, position 38865 of SEQ ID NO: 2, position 38885 of SEQ ID NO: 2, position 38943 of SEQ ID NO: 2, position 39035 of SEQ ID NO: 2, position 39046 of SEQ ID NO: 2, and position 110704 of SEQ ID NO: 2. Polymorphic variants at the following positions in particular were associated with an increased risk of breast cancer: rs2575677, rs2575674, rs1436524, rs2575672, rs2589518, rs2589514, rs3775166, MAPK10-AB, rs3775168, rs2043650, rs2043649, rs1541998, position 38865 of SEQ ID NO: 2, position 39035 of SEQ ID NO: 2, position 39046 of SEQ ID NO: 2, rs1469870, and rs3775176. At these positions in SEQ ID NO: 2, a guanine at position 13918, an adenine at position 23841, an adenine at position 26072, a thymine at position 26376, an adenine at position 26614, an adenine at position 26827, a cytosine at position 27084, an adenine at position 30965, an adenine at position 32979, an adenine at position 35142, a thymine at position 35237, a cytosine at position 36439, a thymine at position 38865, a thymine at position 39035, a cytosine at position 39046, a cytosine at position 46191, and an adenine at position 62587, in particular were associated with risk of breast cancer.
In the KIAA0861 locus, these included polymorphic variants at positions selected from the group consisting of rs3811728, rs3811729, rs602646, rs488277, rs1629673, rs670232, rs575326, rs575386, rs684846, rs471365, rs496251, rs831246, rs831247, rs512071, rs1502761, rs681516, rs683302, rs619424, rs620722, rs529055, rs664010, rs678454, rs2653845, rs472795, rs507079, rs534333, rs535298, rs536213, rs831245, rs639690, rs684174, rs571761, rs1983421, rs4630966, rs2314415, rs6788196, rs2103062, rs9827084, rs9864865, rs6804951, rs6770548, rs1403452, rs7609994, rs9838250, rs9863404, rs903950, rs6787284, rs2017340, rs2001449, rs1317288, rs7635891, rs10704581, rs11371910, rs10937118, rs7642053, rs3821522, rs2029926, rs1390831, rs7643890, rs11925606, rs9826325, rs6800429, rs6803368, rs1353566, rs2272115, rs2272116, rs3732603, rs940055, rs2314730, rs2030578, rs2049280, rs3732602, rs2293203, rs7639705, and position 13507 of SEQ ID NO: 3. Polymorphic variants at the following positions in particular were associated with an increased risk of breast cancer: rs4630966, rs9827084, rs9864865, rs6804951, rs6770548, rs1403452, and rs2001449. At these positions in SEQ ID NO: 3, a cytosine at position 41716, a guanine at position 44775, a guanine at position 44962, a cytosine at position 45317, a guanine at position 45712, a thymine at position 45941, and a cytosine at position 48849, in particular were associated with risk of breast cancer. Also, an alanine at amino acid position 819 in SEQ ID NO: 22 (or position 902 in SEQ ID NO: 23) was in particular associated with an increased risk of breast cancer.
In the NUMA1 locus, these included polymorphic variants at positions corresponding to these selected from the group consisting of rs4945392, rs7938496, rs7926550, rs7945374, rs7949480, rs7102523, rs7121260, rs7131230, rs7128317, rs2276385, rs2276384, rs2276383, rs1892921, rs1892920, rs7942626, rs7124429, rs7114081, rs7125718, rs1055452, rs3829215, rs1541306, rs3814722, rs1939240, rs5743655, rs5743656, rs5743657, rs3814721, rs5743658, rs5743659, rs5743660, rs5743661, rs5743662, rs2298455, rs5743664, rs5743665, rs5743667, rs5743668, rs5743669, rs1573503, rs5743670, rs5743671, rs1892919, rs5743672, rs2735786, rs5743673, rs5743674, rs1062452, rs5743675, rs5743676, rs760246, rs11345794, rs5743677, rs5743678, rs14537, rs3168177, rs5743679, rs1541304, rs1053725, rs5743680, rs949324, rs949323, rs5743681, rs5743682, rs5743683, rs5743684, rs5743685, rs2845857, rs2852365, rs11538641, rs11538639, rs11235417, rs11538644, rs11538643, rs2845858, rs2155146, rs2852364, rs2845859, rs2845860, rs11538642, rs7949430, rs7938674, rs2735787, rs11538640, rs10736784, rs10736785, rs11826059, rs2503, rs2155145, rs4477459, position 26334 of SEQ ID NO: 4, rs5019605, rs5019604, rs5019603, rs3793941, rs11235418, rs3793940, rs2032353, rs3934448, rs7951267, rs1053603, rs1053602, rs11235419, rs1053601, rs3750913, rs3750912, rs1053600, rs1057992, rs2298789, rs10898813, position 34941 of SEQ ID NO: 4, rs949325, position 35629 of SEQ ID NO: 4, rs949326, rs2298456, rs7949845, rs7949989, rs1573500, rs4945411, rs11235422, rs10128658, rs2298457, rs3838779, rs1573501, rs11235424, rs10898814, rs7930142, rs7930544, rs7930721, rs7930722, rs6592456, rs11235425, rs6592457, rs10898815, rs11235426, rs10898816, rs1939247, rs1939246, rs1939245, rs1939244, rs1939243, rs4245463, rs4944258, rs7926751, rs12282917, rs12282918, rs7937582, rs10898817, rs7480015, rs7123992, rs1573502, rs7127865, rs4945426, rs11235428, rs7122489, rs1894003, rs1548348, rs1892923, rs5792570, rs7115200, rs4945430, rs11235429, rs1939242, rs9666346, rs7101553, rs7124000, rs12291664, rs12291778, rs12291781, rs12291787, rs12291788, rs12291833, rs10793016, rs5792571, rs12293529, rs4338555, rs11235431, rs6592458, rs4945434, rs4945435, rs11307657, rs5792573, rs1894004, rs12276164, rs4378421, rs7116495, rs7101701, rs10736786, rs11608165, rs645603, rs661290, rs7122209, rs12417471, rs541228, rs12273666, rs2511074, rs3018311, rs3018289, rs679926, rs567026, rs564294, rs678193, rs677279, rs560777, rs676721, rs7106529, rs11602304, rs585228, rs578957, rs7110215, rs3133233, rs3133230, rs12576024, rs674319, rs675185, rs5792574, rs12275272, rs10400327, rs612255, rs7101643, rs575871, rs547208, rs2511075, rs642573, rs482197, rs656640, rs671681, rs541022, rs951586, rs2511076, rs11235432, rs3018308, rs11606798, rs1791544, rs3018304, rs10751193, rs4945470, rs3018291, rs2511120, rs671132, rs4945475, rs3018292, rs642618, rs552966, rs6592459, rs607446, rs607070, rs10713307, rs3018302, rs3750909, rs3018301, rs2511114, rs12270166, rs12270241, rs11606587, rs686340, rs548961, rs549032, rs575831, rs575878, rs577435, rs579320, rs495567, rs636946, rs493065, rs597513, rs598835, rs10683614, rs610004, rs610041, rs673478, rs670802, rs505041, rs2511116, rs628025, rs517837, rs615000, rs482013, rs693391, rs2511079, rs2250866, rs2508860, rs7483267, rs2511078, rs2508859, rs2508858, rs11235435, rs11235436, rs639435, rs12285624, position 112784 of SEQ ID NO: 4, rs624363, position 113614 of SEQ ID NO: 4, rs1053573, rs1053511, rs1063863, rs12137, rs4365081, rs4466868, rs3750911, rs510925, rs595062, rs1053443, rs542752, rs3897579, rs11235437, rs2508856, rs5792575, rs659513, rs10898820, rs2276397, rs3750908, rs3793938, rs602285, rs2276396, rs2276395, rs1806778, rs4073394, rs471547, rs606136, rs605241, rs686063, rs685749, rs533207, rs476753, position 191149 of SEQ ID NO: 4, rs11278712, and rs3831387. Polymorphic variants at the following positions in particular were associated with an increased risk of breast cancer: rs7949480, rs7121260, rs7128317, rs2276385, rs2276383, rs1892921, rs1541306, rs3814721, rs1892919, rs2852365, rs3750913, position 34941 in SEQ ID NO: 4, rs949325, position 35629 in SEQ ID NO: 4, rs2298456, rs1573500, rs4945411, rs10128658, rs2298457, rs3838779, rs10898814, rs7930142, rs7930544, rs7930722, rs1939247, rs1939243, rs4245463, rs4944258, rs7926751, rs1573502, rs7127865, rs1894003, rs4945430, rs1939242, rs10793016, rs4945434, rs678193, rs560777, rs676721, rs585228, rs675185, rs5792574, rs2511075, rs541022, rs1791544, rs642618, rs552966, rs607446, rs3018302, rs3018301, rs2511114, rs548961, rs579320, rs495567, rs493065, rs610004, rs610041, rs673478, rs670802, rs2511116, rs615000, rs482013, rs2511079, rs2250866, rs2508858, rs2276396, and rs11278712. At these positions in SEQ ID NO: 4, a thymine at position 3146, a guanine at position 6124, an adenine at position 6925, a guanine at position 7060, an adenine at position 7090, a cytosine at position 7696, a cytosine at position 13571, a guanine at position 14830, a cytosine at position 17733, a guanine at position 20776, a guanine at position 31726, a cytosine at position 34941, an adenine at position 35214, a guanine at position 35629, a thymine at position 36273, a cytosine at position 38348, a guanine at position 38608, a cytosine at position 39077, a thymine at position 39769, a thymine at position 40555, a thymine at position 42063, a cytosine at position 42574, a cytosine at position 42912, a cytosine at position 43042, a thymine at position 46079, a cytosine at position 48293, a cytosine at position 48771, a thymine at position 48951, a thymine at position 49972, a guanine at position 52986, a guanine at position 53339, a thymine at position 55834, a guanine at position 58703, a cytosine at position 59140, a guanine at position 60621, a cytosine at position 64645, a thymine at position 75831, a thymine at position 76160, a cytosine at position 76196, a cytosine at position 78847, a thymine at position 81130, a deletion at position 81452, a thyrnine at position 85815, a guanine at position 88614, a cytosine at position 90515, a cytosine at position 93751, an adenine at position 93775, a cytosine at position 94810, a thymine at position 96500, an adenine at position 97629, a thymine at position 97705, a guanine at position 99445, a guanine at position 100512, a cytosine at position 101046, an adenine at position 102487, a cytosine at position 103497, an adenine at position 103526, a cytosine at position 104662, a thymine at position 105226, a cytosine at position 107718, a thymine at position 108510, a cytosine at position 109520, a cytosine at position 109712, a thymine at position 110071, a cytosine at position 110963, a guanine at position 129463, and a “GTCAAC” at positions 34468-34472, in particular were associated with risk of breast cancer.
In the GALE locus, these included polymorphic variants at positions selected from the group consisting of rs627451, rs12082331, rs2267960, rs7519640, rs12086741, rs3934189, rs12135415, rs12088267, rs12084665, rs550850, rs557227, rs12137502, rs12118858, rs2294495, rs12401650, rs2235541, rs520713, rs550252, position 12668 of SEQ ID NO: 5, rs12093683, rs10917421, rs2744873, rs12091764, position 15761 of SEQ ID NO: 5, rs2076345, rs2076346, rs2473379, rs6679300, rs11811395, rs8179467, rs8179468, rs10917423, rs7536699, rs3215497, rs1000213, rs1000212, rs1000211, rs1045017, rs12059520, rs2143118, rs12126804, rs533276, rs12402174, rs2864110, rs11581873, rs12062449, rs12033190, rs10157566, rs486746, rs11802707, rs6668550, rs7410946, rs7410970, rs6657558, rs2143119, rs7514394, rs11591202, rs6673991, position 37720 of SEQ ID NO: 5, rs12034848, rs2502984, rs3831910, rs11379444, rs725119, rs10917425, rs12077788, rs12077830, rs2473380, rs2473381, rs11545132, rs1046924, rs4237, rs4375317, rs11584220, rs2232975, rs2502985, rs3835423, rs2232976, rs2232977, rs2232978, rs2232979, rs2232980, rs2232981, rs2232982, rs2232983, rs2232984, rs2232985, rs2232986, rs2745, rs2744, rs11546127, rs1049988, rs1803613, rs1803612, position 55821 of SEQ ID NO: 5, rs3209973, rs3180545, rs3180383, rs3177814, rs3180546, rs3180547, rs11805398, rs760941, rs3177813, rs3180548, rs3179864, rs3177812, rs3179863, rs6692104, rs3180549, rs3179862, rs3177811, rs3177810, rs3180382, rs11546126, rs7551384, rs12141511, rs2473382, rs12038166, rs6666908, rs12041159, rs12031592, rs1062598, rs11714, rs3203593, rs1042436, rs2076343, rs12131539, rs11583935, rs12140263, rs3835225, rs2473374, rs2256179, rs974698, rs1018396, rs719399, rs719400, rs2502986, rs6679378, rs2473375, rs2473376, rs12136455, rs2502987, rs11551767, rs11591205, rs12083298, rs12138604, rs12136042, rs12138606, rs12136045, rs12116596, rs12138610, rs12136069, rs12116617, rs7540056, rs12044452, rs2076344, rs11588187, rs6696932, rs12025531, rs6682888, rs2982390, rs2179394, rs2473377, rs2179395, rs2502978, rs2502979, rs6698535, rs2502980, rs6697805, rs6424114, rs5773058, rs4649114, rs6424115 and rs10554242. Polymorphic variants at the following positions in particular were associated with an increased risk of breast cancer: rs2294495, position 15761 of SEQ ID NO: 5, rs8179467, rs11591202, rs12034848, rs3831910, rs4237, rs2232982, rs12041159, rs2076343, rs1018396, rs12044452, rs2982390, rs2502980, rs6697805, and rs10554242. At these positions in SEQ ID NO: 5, a cytosine at position 9351, a thymine at position 15761, a thymine at position 18220, an adenine at position 35555, a thymine at position 38304, an adenine at position 39985, an adenine at position 47604, a thymine at position 53102, a guanine at position 61135, an adenine at position 62601, a thymine at position 67087, a guanine at position 77120, a cytosine at position 81305, a cytosine at position 83464, a cytosine at position 85471, and a deletion at positions 83916-83920, in particular were associated with risk of breast cancer.
In the DPF3 locus, these included polymorphic variants at positions selected from the group consisting of rs11846274, rs2526935, rs929328, rs3742840, rs9671739, rs8006208, rs8006230, rs8007836, rs8006889, rs8010823, rs8011029, rs10649920, rs2803956, rs2803957, rs2526934, rs9671558, rs2526933, rs2803959, rs2526932, rs2803960, rs12434675, rs4899435, rs2526931, rs2803961, rs2803962, rs12590634, rs11327712, rs2803963, rs11844834, rs11320415, rs8012752, rs11623878, rs11623926, rs12434442, rs2526930, rs12435306, rs10144028, rs4899436, rs7140593, rs2107687, rs991882, rs3327, rs2526928, rs7401336, rs2526926, rs994760, rs994759, rs994758, rs11848404, rs2526925, rs11844236, rs2526924, rs2803965, rs2526923, rs7152467, rs11623462, rs2803966, rs2526922, rs2526920, rs11848135, rs11629210, rs2803967, rs16455, rs757655, rs5809581, rs3057139, rs2247658, rs11625609, rs8005580, rs8010472, rs2526919, rs2803968, rs11623943, rs11623946, rs1557926, rs12434611, rs2526918, rs5809582, rs8008279, rs2803969, rs2526917, rs8008774, rs2803970, rs8010255, rs2997642, rs2803971, rs11313760, rs2803972, rs4903038, rs2526916, rs4903040, rs2803974, rs2803975, rs2803976, rs2803977, rs10139909, rs722945, rs917069, rs2803978, rs2332890, rs1989638, rs10679174, rs2526915, rs2526914, rs11158964, rs11158965, rs740081, rs740080, rs10140582, rs2526913, rs4899437, rs10145678, rs2107686, rs2107685, rs2107684, rs7154188, rs4903041, rs7159637, rs6574089, rs12589753, rs4899438, rs4903042, rs4903043, rs2803980, rs10483848, rs2240344, rs2286068, rs11339669, rs3854, rs11463, rs1383, rs1381, rs1377, rs11158966, rs11158967, rs11158968, rs11158969, rs11158970, rs11158971, rs11849782, rs10137616, rs757572, rs10140566, rs2023480, rs2526911, rs4903044, rs11845162, rs12147210, rs2997643, rs2997644, rs3814867, rs2286067, rs1060570, rs2332891, rs2021736, rs7160830, rs2526909, rs7140963, rs10143667, rs2803981, rs768840, rs5809587, rs2023479, rs4903045, rs4903046, rs5809588, rs10220555, rs2906132, rs11848482, rs10129954, rs2526921, rs4903047, rs11846357, rs10136385, rs12588242, rs11621517, rs2526910, rs2526941, rs2803944, rs12436770, rs10220279, rs10220280, rs11844112, rs12432455, rs8015338, rs3832969, rs9671972, rs9671975, rs7159986, rs11848220, rs5016369, rs1986423, rs2332909, rs8013337, rs11445680, rs4903048, rs12434793, rs2332910, rs4410017, rs4577019, rs2332911, rs4996747, rs10140820, rs12431623, rs6574090, rs8008750, rs11627420, rs10150185, rs10150218, rs9646164, rs6574091, rs2332912, rs7155359, rs2332913, rs4544184, rs4337224, rs2332914, rs4280167, rs4903049, rs3742837, rs10139937, rs12434292, rs11620671, rs10140184, rs2332915, rs2332916, rs8012759, rs10149272, rs11158973, rs4903050, rs10666445, rs2536143, rs10638231, rs12431636, rs8005904, rs11621058, rs10133224, rs12433185, rs740974, rs740973, rs740972, rs740971, rs4243642, rs4415952, rs2215589, rs4343211, rs2536142, rs11293340, rs10151620, rs2286840, rs8023089, rs8008009, rs11419089, rs10694676, rs2536141, rs765247, rs7147626, rs10132629, rs4903051, rs11158974, rs1035021, rs6574093, rs4899439, rs7155287, rs7154402, rs7154781, rs6574094, rs10132242, rs10146959, rs10147466, rs11626411, rs4899440, rs10144553, rs11627663, rs11627799, rs11851733, rs10140317, rs8007375, rs4899441, rs11158975, rs11419607, rs2109793, rs8023156, rs10140579, rs7148199, rs7146916, rs1990439, rs6574095, rs10140037, rs8007249, rs1990438, rs1990437, rs10146484, rs11627333, rs7155802, rs2109792, rs11429363, rs8004210, rs2098194, rs2109791, rs11381729, rs1160094, rs11628051, rs10136771, rs10139903, rs4903053, rs3742836, rs3742835, rs8003233, rs11621588, rs740981, rs8019492, rs8019644, rs8019646, rs8019653, rs11450794, rs11348193, rs11450793, rs11282735, rs2191823, rs12232220, rs11158976, rs4903054, rs11846755, rs12431988, rs12100526, rs11622568, rs9671230, rs12147487, rs4903055, rs12147515, rs11625092, rs4899442, rs2052146, rs10220553, rs10220565, rs2332917, rs7158910, rs8015749, rs8006812, rs8008338, rs2052145, rs2052144, rs10146692, rs11627305, rs2079989, rs8018881, rs4561387, rs11622025, rs740980, rs12433250, rs5809590, rs758915, rs758914, rs7154229, rs12437188, rs7159108, rs4903058, rs4899443, rs11848907, rs12432148, rs12435078, rs6574096, rs11158977, rs11629434, rs4378563, rs2098195, rs4633653, rs7148350, rs740979, rs740978, rs740977, rs740976, rs4903059, rs4903060, rs11852056, rs9635257, rs9635258, rs9635259, rs4899444, rs12435382, rs12435412, rs11627381, rs2052143, rs2052142, rs2052141, rs8021035, rs11158978, rs11621216, rs10130873, rs11621358, rs758913, rs11622602, rs10136931, rs740975, rs747987, rs11623819, rs12434445, rs8003375, rs10143596, rs12435321, rs12435401, rs8010609, rs11158979, rs11158980, rs11627524, rs1126160, rs10136074, rs4903061, rs10665398, rs6574097, rs9671654, rs10140024, rs10142421, rs10142593, rs11423372, rs5809592, rs2332918, rs2332919, rs8007348, rs1990443, rs8007690, rs3937455, rs8012823, rs4899445, rs4903062, rs973963, rs10149962, rs8003449, rs11620775, rs8009089, rs8008967, rs12050132, rs10133018, rs1990442, rs1990441, rs8015833, rs1990440, rs4903063, rs10139810, rs4903064, rs2159715, rs2109795, rs2159714, rs11623107, rs7152005, rs7152489, rs4479167, rs4606655, rs4606656, rs4489943, rs7142642, rs8006233, rs8007559, rs8006156, rs1468662, rs11627048, rs6574098, rs12433760, rs12433780, rs12434506, rs12434673, rs12431400, rs12431384, rs4903067, rs2332920, rs2215591, rs12433064, rs12436263, rs12433097, rs12433184, rs8015900, rs11296981, rs11344025, rs11464204, rs11441172, rs11381807, rs10873251, rs2109794, rs10873252, rs4520784, rs2877820, rs2877821, rs4569195, rs11628905, rs2191822, rs2191821, rs11464689, rs12431959, rs4903068, rs1544579, rs7155879, rs12433603, rs11351432, rs11448438, rs4243643, rs4140952, rs8005372, rs8004109, rs8008398, rs8009692, rs2332921, rs12050320, rs12050323, rs8010316, rs7154293, rs12147969, rs2215590, rs4265749, rs1004552, rs4307892, rs12431973, rs12431975, rs767874, rs11628597, rs10129371, rs4903069, rs4903070, rs4903071, rs11622224, rs10459455, rs9323577, rs10624648, rs3058953, rs11158981, rs11158982, rs11158983, rs1860750, rs1860749, rs1860748, rs1860747, rs11419679, rs8011777, rs6574099, rs8010957, rs11626895, rs10151431, rs4903072, rs4589489, rs9671327, rs4899446, rs10144501, rs5809594, rs720317, rs8014316, rs11158984, rs6420906, rs8004055, rs12434800, rs4243644, rs4899447, rs4903073, rs11848634, rs4899448, rs10131564, rs10134150, rs763388, rs11845938, rs11845946, rs11845915, rs10137463, rs6574100, rs7140344, rs10646889, rs7146287, rs5809595, rs1035099, rs7159877, rs7142579, rs12431762, rs12431764, rs10647999, rs6574101, rs6574102, rs1861162, rs12432972, rs10146134, rs10146616, rs10146769, rs8018936, rs10483849, rs2160137, rs2192595, rs2192594, rs11271695, rs10747301, rs12050363, rs12050368, rs12432949, rs7401375, rs8019682, rs8021248, rs11158985, rs10483850, rs8010875, rs11626844, rs982972, rs7161198, rs7160347, rs8007139, rs8014483, rs12437072, rs8004767, rs12588830, rs7158449, rs6574103, rs8020478, rs4903077, rs8012359, rs4899449, rs10690289, rs6574104, rs2110552, rs8008256, rs759283, rs4999177, rs2333006, rs8006178, rs11158986, rs7150625, rs8007768, rs8007058, position 284742 of SEQ ID NO: 6, rs2215901, rs3814866, rs3814864, and rs10605948. Polymorphic variants at the following positions in particular were associated with an increased risk of breast cancer: rs3327, rs2526926, rs2526914, rs2526913, rs2526921, rs7159986, rs2332916, rs10132242, rs11627663, rs4899441, rs7148199, rs1990437, rs8004210, rs8019653, rs12232220, rs4899442, rs2332917, rs8015749, rs12437188, rs12432148, rs4378563, rs740978, rs740976, rs4903059, rs4903060, rs9635259, rs2052142, rs758913, rs747987, rs11423372, rs5809592, rs8007348, rs4899445, rs4903062, rs1990440, rs4479167, rs4606655, rs4606656, rs4489943, rs8007559, rs8006156, rs12431400, rs12431384, rs12433097, rs12433184, rs2877821, rs4569195, rs11628905, rs2191822, rs12433603, rs11448438, rs8009692, rs4265749, rs4307892, rs12431975, rs4903071, rs1860749, rs1860748, rs8010957, rs6420906, rs12434800, rs7142579, rs8010875, rs8004767, rs4899449, and rs10605948. At these positions in SEQ ID NO: 6, a thymine at position 17641, a thymine at position 19527, a thymine at position 40889, an adenine at position 44877, a cytosine at position 75061, a thymine at position 86006, a cytosine at position 106988, a guanine at position 122783, a cytosine at position 125329, an adenine at position 127544, a cytosine at position 131734, a cytosine at position 137499, an adenine at position 139319, a guanine at position 147479, a guanine at position 150798, a guanine at position 160835, a guanine at position 163447, a guanine at position 164377, a cytosine at position 171972, a guanine at position 173467, a thymine at position 177780, a guanine at position 179608, a thymine at position 179808, a cytosine at position 180041, a guanine at position 181420, a guanine at position 182248, a guanine at position 185633, a guanine at position 188352, a thymine at position 189444, a cytosine at position 196415, a cytosine at position 196417, an adenine at position 196621, a guanine at position 197612, a cytosine at position 197854, a guanine at position 201045, a cytosine at position 205135, a thymine at position 205269, a thymine at position 205323, an adenine at position 205364, an adenine at position 206786, a guanine at position 206796, a thymine at position 209750, a guanine at position 209817, a guanine at position 211659, a thymine at position 211757, an adenine at position 213029, a guanine at position 213095, a cytosine at position 214247, a cytosine at position 214807, a guanine at position 217143, a guanine at position 217725, a thymine at position 218890, a thymine at position 222234, an adenine at position 222458, an adenine at position 222749, a thymine at position 227815, an adenine at position 233670, a cytosine at position 233702, a guanine at position 237317, a thymine at position 242360, an adenine at position 243355, an adenine at position 251858, a guanine at position 267130, a cytosine at position 273399, a guanine at position 277166, and a deletion at positions 250079-250082, in particular were associated with risk of breast cancer.
In the LOC145197 locus, these included polymorphic variants at positions selected from the group consisting of rs2895907, rs2401019, rs2401020, rs2401021, rs1999611, rs1999610, rs1999609, rs2275016, rs2275015, rs3818772, rs10149458, rs7142383, rs11343023, rs11160641, rs12586334, rs10142208, rs7493230, rs5811036, rs10151926, rs12435354, rs7151007, rs11160642, rs11160643, rs11626687, rs4906112, rs8016071, rs11623698, rs7401628, rs8015995, rs10873526, rs11160644, rs10134252, rs1959030, rs9707396, rs2401022, rs4622448, rs10141019, rs10141096, rs11621063, rs12434632, rs12100901, rs12434655, rs9944103, rs7153189, rs7158860, rs12437080, rs11851768, rs12431943, rs4309341, rs4329858, rs10690268, rs2401023, rs1054745, rs8019453, rs12431510, rs7141067, rs12431547, rs7142316, rs1959029, rs1959028, rs11376292, rs11376755, rs7145420, rs8013347, rs2144070, rs11850135, rs11850138, rs1955617, rs11621899, rs4900508, rs4906116, rs4906117, rs2235972, rs2235973, rs2235974, rs2235975, rs7149416, rs11850809, rs10140476, rs12437309, rs6575852, rs4906118, rs11428825, rs11450744, rs1999612, rs1889368, rs1889367, rs1889366, rs3077388, rs1889365, rs1955615, rs1569807, rs2064491, rs2064492, rs761532, rs1955616, rs2144065, rs2144066, rs2895908, rs2401043, rs1007904, rs3891113, rs3891114, rs730812, rs1884068, and rs1884069. Polymorphic variants at the following positions in particular were associated with an increased risk of breast cancer: rs12437080, rs12431943, rs1054745, rs8019453, rs12431547, rs1959029, rs1959028, rs8013347, rs2235972, rs2235973, rs2235974, and rs2895908. At these positions in SEQ ID NO: 7, a guanine at position 41414, an adenine at position 42821, an adenine at position 46344, a cytosine at position 46669, an adenine at position 47293, a guanine at position 49821, a thymine at position 49875, a thymine at position 51912, a cytosine at position 55799, a cytosine at position 55995, an adenine at position 56042, and an adenine at position 75221, in particular were associated with risk of breast cancer.
Based in part upon analyses summarized in FIGS. 1A-1G, regions with significant association have been identified in ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 regions associated with increased risk of breast cancer. Any polymorphic variants associated with an increased risk of breast cancer in a region of significant association can be utilized for embodiments described herein. The following reports such a region, where “begin” and “end” designate the boundaries of the region according to chromosome positions within NCBI's Genome Build 34. For example, a region spanning positions 184215647 to 184249849 in the KIAA0861 locus was significantly associated with an increased risk of breast cancer.
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rs #RegionRegion of AssociationDistance
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4237HT014 region235453512362219676845
2001449KIAA086118421564718424984934202
1541998MAPK10873860188744287456856
673478NUMA17142389671531713107817
1054745LOC145197998955649992937133807
1990440DPF37107832771343316264989
11549918ICAM1,4,5102315421026816936627
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The embodiments described hereafter may be directed to any of the polymorphic variants described herein. Sometimes, embodiments are directed to any of the polymorphic variants described herein with the proviso that the embodiments are not directed to a polymorphic variant at one or more positions selected from the group consisting of rs11549918, rs1541998, rs2001449, rs673478, rs4237, rs1990440 and rs1054745.
Additional Polymorphic Variants Associated with Breast Cancer
Also provided is a method for identifying polymorphic variants proximal to an incident, founder polymorphic variant associated with breast cancer. Thus, featured herein are methods for identifying a polymorphic variation associated with breast cancer that is proximal to an incident polymorphic variation associated with breast cancer, which comprises identifying a polymorphic variant proximal to the incident polymorphic variant associated with breast cancer, where the incident polymorphic variant is in a nucleotide sequence set forth in SEQ ID NO: 1-7. The nucleotide sequence often comprises a polynucleotide sequence selected from the group consisting of (a) a nucleotide sequence set forth in SEQ ID NO: 1-7; (b) a nucleotide sequence which encodes a polypeptide having an amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-7; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-7 or a nucleotide sequence about 90% or more identical to the nucleotide sequence set forth in SEQ ID NO: 1-7; and (d) a fragment of a nucleotide sequence of (a), (b), or (c), often a fragment that includes a polymorphic site associated with breast cancer. The presence or absence of an association of the proximal polymorphic variant with breast cancer then is determined using a known association method, such as a method described in the Examples hereafter. In an embodiment, the incident polymorphic variant is described in SEQ ID NO: 1-7. In another embodiment, the proximal polymorphic variant identified sometimes is a publicly disclosed polymorphic variant, which for example, sometimes is published in a publicly available database. In other embodiments, the polymorphic variant identified is not publicly disclosed and is discovered using a known method, including, but not limited to, sequencing a region surrounding the incident polymorphic variant in a group of nucleic acid samples. Thus, multiple polymorphic variants proximal to an incident polymorphic variant are associated with breast cancer using this method.
The proximal polymorphic variant often is identified in a region surrounding the incident polymorphic variant. In certain embodiments, this surrounding region is about 50 kb flanking the first polymorphic variant (e.g. about 50 kb 5′ of the first polymorphic variant and about 50 kb 3′ of the first polymorphic variant), and the region sometimes is composed of shorter flanking sequences, such as flanking sequences of about 40 kb, about 30 kb, about 25 kb, about 20 kb, about 15 kb, about 10 kb, about 7 kb, about 5 kb, or about 2 kb 5′ and 3′ of the incident polymorphic variant. In other embodiments, the region is composed of longer flanking sequences, such as flanking sequences of about 55 kb, about 60 kb, about 65 kb, about 70 kb, about 75 kb, about 80 kb, about 85 kb, about 90 kb, about 95 kb, or about 100 kb 5′ and 3′ of the incident polymorphic variant.
In certain embodiments, polymorphic variants associated with breast cancer are identified iteratively. For example, a first proximal polymorphic variant is associated with breast cancer using the methods described above and then another polymorphic variant proximal to the first proximal polymorphic variant is identified (e.g., publicly disclosed or discovered) and the presence or absence of an association of one or more other polymorphic variants proximal to the first proximal polymorphic variant with breast cancer is determined.
The methods described herein are useful for identifying or discovering additional polymorphic variants that may be used to further characterize a gene, region or loci associated with a condition, a disease (e.g., breast cancer), or a disorder. For example, allelotyping or genotyping data from the additional polymorphic variants may be used to identify a functional mutation or a region of linkage disequilibrium.
In certain embodiments, polymorphic variants identified or discovered within a region comprising the first polymorphic variant associated with breast cancer are genotyped using the genetic methods and sample selection techniques described herein, and it can be determined whether those polymorphic variants are in linkage disequilibrium with the first polymorphic variant. The size of the region in linkage disequilibrium with the first polymorphic variant also can be assessed using these genotyping methods. Thus, provided herein are methods for determining whether a polymorphic variant is in linkage disequilibrium with a first polymorphic variant associated with breast cancer, and such information can be used in prognosis methods described herein.
Isolated ICAM, MAPK10, KIAA0861. NUMA1. GALE, DPF3 and LOC145197 Nucleic Acids
Featured herein are isolated ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acids, which include the nucleic acid having the nucleotide sequence of SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11, nucleic acid variants, and substantially identical nucleic acids of the foregoing. Nucleotide sequences of the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acids sometimes are referred to herein as “ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequences.” An “ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid variant” refers to one allele that may have one or more different polymorphic variations as compared to another allele in another subject or the same subject. A polymorphic variation in the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid variant may be represented on one or both strands in a double-stranded nucleic acid or on one chromosomal complement (heterozygous) or both chromosomal complements (homozygous).
As used herein, the term “nucleic acid” includes DNA molecules (e.g., a complementary DNA (cDNA) and genomic DNA (gDNA)) and RNA molecules (e.g., mRNA, rRNA, and tRNA) and analogs of DNA or RNA, for example, by use of nucleotide analogs. The nucleic acid molecule can be single-stranded and it is often double-stranded. The term “isolated or purified nucleic acid” refers to nucleic acids that are separated from other nucleic acids present in the natural source of the nucleic acid. For example, with regard to genomic DNA, the term “isolated” includes nucleic acids which are separated from the chromosome with which the genomic DNA is naturally associated. An “isolated” nucleic acid is often free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5′ and/or 3′ ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated nucleic acid molecule can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of 5′ and/or 3′ nucleotide sequences which flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived. Moreover, an “isolated” nucleic acid molecule, such as a cDNA molecule, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or substantially free of chemical precursors or other chemicals when chemically synthesized. As used herein, the term “ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 gene” refers to a nucleotide sequence that encodes a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide.
Also included herein are nucleic acid fragments. These fragments typically are a nucleotide sequence identical to a nucleotide sequence in SEQ ID NO: 1-17, a nucleotide sequence substantially identical to a nucleotide sequence in SEQ ID NO: 1-17, or a nucleotide sequence that is complementary to the foregoing. The nucleic acid fragment may be identical, substantially identical or homologous to a nucleotide sequence in an exon or an intron in SEQ ID NO: 1-7, and may encode a domain or part of a domain or motif of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. Sometimes, the fragment will comprises the polymorphic variation described herein as being associated with breast cancer. The nucleic acid fragment sometimes is 50, 100, or 200 or fewer base pairs in length, and is sometimes about 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500, 1600, 1700, 1800, 1900, 2000, 2100, 2200, 2300, 2400, 2500, 2600, 2700, 2800, 2900, 3000, 3100, 3200, 3300, 3400, 3500, 3600, 3800, 4000, 5000, 6000, 7000, 8000, 9000, 10000, 15000, 20000, 30000, 40000, 50000, 60000, 70000, 80000, 90000, 100000, 110000, 120000, 130000, 140000, 150000 or 160000 base pairs in length. A nucleic acid fragment complementary to a nucleotide sequence identical or substantially identical to the nucleotide sequence of SEQ ID NO: 1-17 and hybridizes to such a nucleotide sequence under stringent conditions often is referred to as a “probe.” Nucleic acid fragments often include one or more polymorphic sites, or sometimes have an end that is adjacent to a polymorphic site as described hereafter.
An example of a nucleic acid fragment is an oligonucleotide. As used herein, the term “oligonucleotide” refers to a nucleic acid comprising about 8 to about 50 covalently linked nucleotides, often comprising from about 8 to about 35 nucleotides, and more often from about 10 to about 25 nucleotides. The backbone and nucleotides within an oligonucleotide may be the same as those of naturally occurring nucleic acids, or analogs or derivatives of naturally occurring nucleic acids, provided that oligonucleotides having such analogs or derivatives retain the ability to hybridize specifically to a nucleic acid comprising a targeted polymorphism. Oligonucleotides described herein may be used as hybridization probes or as components of prognostic or diagnostic assays, for example, as described herein.
Oligonucleotides are typically synthesized using standard methods and equipment, such as the ABI 3900 High Throughput DNA Synthesizer and the EXPEDITE™ 8909 Nucleic Acid Synthesizer, both of which are available from Applied Biosystems (Foster City, Calif.). Analogs and derivatives are exemplified in U.S. Pat. Nos. 4,469,863; 5,536,821; 5,541,306; 5,637,683; 5,637,684; 5,700,922; 5,717,083; 5,719,262; 5,739,308; 5,773,601; 5,886,165; 5,929,226; 5,977,296; 6,140,482; WO 00/56746; WO 01/14398, and related publications. Methods for synthesizing oligonucleotides comprising such analogs or derivatives are disclosed, for example, in the patent publications cited above and in U.S. Pat. Nos. 5,614,622; 5,739,314; 5,955,599; 5,962,674; 6,117,992; in WO 00/75372; and in related publications.
Oligonucleotides also may be linked to a second moiety. The second moiety may be an additional nucleotide sequence such as a tail sequence (e.g., a polyadenosine tail), an adapter sequence (e.g., phage M13 universal tail sequence), and others. Alternatively, the second moiety may be a non-nucleotide moiety such as a moiety which facilitates linkage to a solid support or a label to facilitate detection of the oligonucleotide. Such labels include, without limitation, a radioactive label, a fluorescent label, a chemiluminescent label, a paramagnetic label, and the like. The second moiety may be attached to any position of the oligonucleotide, provided the oligonucleotide can hybridize to the nucleic acid comprising the polymorphism.
Uses for Nucleic Acid Sequences
Nucleic acid coding sequences depicted in SEQ ID NO: 1-17 may be used for diagnostic purposes for detection and control of polypeptide expression. Also, included herein are oligonucleotide sequences such as antisense RNA, small-interfering RNA (siRNA) and DNA molecules and ribozymes that function to inhibit translation of a polypeptide. Antisense techniques and RNA interference techniques are known in the art and are described herein.
Ribozymes are enzymatic RNA molecules capable of catalyzing the specific cleavage of RNA. The mechanism of ribozyme action involves sequence specific hybridization of the ribozyme molecule to complementary target RNA, followed by a endonucleolytic cleavage. Ribozymes may be engineered hammerhead motif ribozyme molecules that specifically and efficiently catalyze endonucleolytic cleavage of RNA sequences corresponding to or complementary to the nucleotide sequences set forth in SEQ ID NO: 1-17. Specific ribozyme cleavage sites within any potential RNA target are initially identified by scanning the target molecule for ribozyme cleavage sites which include the following sequences, GUA, GUU and GUC. Once identified, short RNA sequences of between fifteen (15) and twenty (20) ribonucleotides corresponding to the region of the target gene containing the cleavage site may be evaluated for predicted structural features such as secondary structure that may render the oligonucleotide sequence unsuitable. The suitability of candidate targets may also be evaluated by testing their accessibility to hybridization with complementary oligonucleotides, using ribonuclease protection assays.
Antisense RNA and DNA molecules, siRNA and ribozymes may be prepared by any method known in the art for the synthesis of RNA molecules. These include techniques for chemically synthesizing oligodeoxyribonucleotides well known in the art such as solid phase phosphoramidite chemical synthesis. Alternatively, RNA molecules may be generated by in vitro and in vivo transcription of DNA sequences encoding the antisense RNA molecule. Such DNA sequences may be incorporated into a wide variety of vectors which incorporate suitable RNA polymerase promoters such as the T7 or SP6 polymerase promoters. Alternatively, antisense cDNA constructs that synthesize antisense RNA constitutively or inducibly, depending on the promoter used, can be introduced stably into cell lines.
DNA encoding a polypeptide also may have a number of uses for the diagnosis of diseases, including breast cancer, resulting from aberrant expression of a target gene described herein. For example, the nucleic acid sequence may be used in hybridization assays of biopsies or autopsies to diagnose abnormalities of expression or function (e.g., Southern or Northern blot analysis, in situ hybridization assays).
In addition, the expression of a polypeptide during embryonic development may also be determined using nucleic acid encoding the polypeptide. As addressed, infra, production of functionally impaired polypeptide can be the cause of various disease states, such as breast cancer. In situ hybridizations using polynucleotide probes may be employed to predict problems related to breast cancer. Further, as indicated, infra, administration of human active polypeptide, recombinantly produced as described herein, may be used to treat disease states related to functionally impaired polypeptide. Alternatively, gene therapy approaches may be employed to remedy deficiencies of functional polypeptide or to replace or compete with dysfunctional polypeptide.
Expression Vectors. Host Cells, and Genetically Engineered Cells
Provided herein are nucleic acid vectors, often expression vectors, which contain a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid. As used herein, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked and can include a plasmid, cosmid, or viral vector. The vector can be capable of autonomous replication or it can integrate into a host DNA. Viral vectors may include replication defective retroviruses, adenoviruses and adeno-associated viruses for example.
A vector can include a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid in a form suitable for expression of the nucleic acid in a host cell. The recombinant expression vector typically includes one or more regulatory sequences operatively linked to the nucleic acid sequence to be expressed. The term “regulatory sequence” includes promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Regulatory sequences include those that direct constitutive expression of a nucleotide sequence, as well as tissue-specific regulatory and/or inducible sequences. The design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of polypeptide desired, and the like. Expression vectors can be introduced into host cells to produce ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides, including fusion polypeptides, encoded by ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acids.
Recombinant expression vectors can be designed for expression of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides in prokaryotic or eukaryotic cells. For example, ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides can be expressed in E. coli, insect cells (e.g., using baculovirus expression vectors), yeast cells, or mammalian cells. Suitable host cells are discussed further in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.
Expression of polypeptides in prokaryotes is most often carried out in E. coli with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion polypeptides. Fusion vectors add a number of amino acids to a polypeptide encoded therein, usually to the amino terminus of the recombinant polypeptide. Such fusion vectors typically serve three purposes: 1) to increase expression of recombinant polypeptide; 2) to increase the solubility of the recombinant polypeptide; and 3) to aid in the purification of the recombinant polypeptide by acting as a ligand in affinity purification. Often, a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant polypeptide to enable separation of the recombinant polypeptide from the fusion moiety subsequent to purification of the fusion polypeptide. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase. Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith & Johnson, Gene 67: 3140 (1988)), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) which fuse glutathione S-transferase (GST), maltose E binding polypeptide, or polypeptide A, respectively, to the target recombinant polypeptide.
Purified fusion polypeptides can be used in screening assays and to generate antibodies specific for ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides. In a therapeutic embodiment, fusion polypeptide expressed in a retroviral expression vector is used to infect bone marrow cells that are subsequently transplanted into irradiated recipients. The pathology of the subject recipient is then examined after sufficient time has passed (e.g., six (6) weeks).
Expressing the polypeptide in host bacteria with an impaired capacity to proteolytically cleave the recombinant polypeptide is often used to maximize recombinant polypeptide expression (Gottesman, S., Gene Expression Technology: Methods in Enzymology, Academic Press, San Diego, Calif. 185: 119-128 (1990)). Another strategy is to alter the nucleotide sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in E. coli (Wada et al., Nucleic Acids Res. 20: 2111-2118 (1992)). Such alteration of nucleotide sequences can be carried out by standard DNA synthesis techniques.
When used in mammalian cells, the expression vector's control functions are often provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40. Recombinant mammalian expression vectors are often capable of directing expression of the nucleic acid in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Non-limiting examples of suitable tissue-specific promoters include an albumin promoter (liver-specific; Pinkert et al., Genes Dev. 1: 268-277 (1987)), lymphoid-specific promoters (Calame & Eaton, Adv. Immunol. 43: 235-275 (1988)), promoters of T cell receptors (Winoto & Baltimore, EMBO J. 8: 729-733 (1989)) promoters of immunoglobulins (Banerji et al., Cell 33: 729-740 (1983); Queen & Baltimore, Cell 33: 741-748 (1983)), neuron-specific promoters (e.g., the neurofilament promoter; Byrne & Ruddle, Proc. Natl. Acad. Sci. USA 86: 5473-5477 (1989)), pancreas-specific promoters (Edlund et al., Science 230: 912-916 (1985)), and mammary gland-specific promoters (e.g., milk whey promoter; U.S. Pat. No. 4,873,316 and European Application Publication No. 264,166). Developmentally-regulated promoters are sometimes utilized, for example, the murine hox promoters (Kessel & Gruss, Science 249: 374-379 (1990)) and the a-fetopolypeptide promoter (Campes & Tilghman, Genes Dev. 3: 537-546 (1989)).
A ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid may also be cloned into an expression vector in an antisense orientation. Regulatory sequences (e.g., viral promoters and/or enhancers) operatively linked to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid cloned in the antisense orientation can be chosen for directing constitutive, tissue specific or cell type specific expression of antisense RNA in a variety of cell types. Antisense expression vectors can be in the form of a recombinant plasmid, phagemid or attenuated virus. For a discussion of the regulation of gene expression using antisense genes see Weintraub et al., Antisense RNA as a molecular tool for genetic analysis, Reviews—Trends in Genetics, Vol. 1(1) (1986).
Also provided herein are host cells that include a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid within a recombinant expression vector or ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid sequence fragments which allow it to homologously recombine into a specific site of the host cell genome. The terms “host cell” and “recombinant host cell” are used interchangeably herein. Such terms refer not only to the particular subject cell but rather also to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein. A host cell can be any prokaryotic or eukaryotic cell. For example, a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide can be expressed in bacterial cells such as E. coli, insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those skilled in the art.
Vectors can be introduced into host cells via conventional transformation or transfection techniques. As used herein, the terms “transformation” and “transfection” are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g., DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, transduction/infection, DEAE-dextran-mediated transfection, lipofection, or electroporation.
A host cell provided herein can be used to produce (i.e., express) a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. Accordingly, further provided are methods for producing a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide using the host cells described herein. In one embodiment, the method includes culturing host cells into which a recombinant expression vector encoding a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide has been introduced in a suitable medium such that a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide is produced. In another embodiment, the method further includes isolating a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide from the medium or the host cell.
Also provided are cells or purified preparations of cells which include a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 transgene, or which otherwise misexpress ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. Cell preparations can consist of human or non-human cells, e.g., rodent cells, e.g., mouse or rat cells, rabbit cells, or pig cells. In certain embodiments, the cell or cells include a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 transgene (e.g., a heterologous form of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 such as a human gene expressed in non-human cells). The ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 transgene can be misexpressed, e.g., overexpressed or underexpressed. In other embodiments, the cell or cells include a gene which misexpress an endogenous ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide (e.g., expression of a gene is disrupted, also known as a knockout). Such cells can serve as a model for studying disorders which are related to mutated or mis-expressed ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 alleles or for use in drug screening. Also provided are human cells (e.g., a hematopoietic stem cells) transformed with a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid.
Also provided are cells or a purified preparation thereof (e.g., human cells) in which an endogenous ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid is under the control of a regulatory sequence that does not normally control the expression of the endogenous ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 gene. The expression characteristics of an endogenous gene within a cell (e.g., a cell line or microorganism) can be modified by inserting a heterologous DNA regulatory element into the genome of the cell such that the inserted regulatory element is operably linked to the endogenous ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 gene. For example, an endogenous ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 gene (e.g., a gene which is “transcriptionally silent,” not normally expressed, or expressed only at very low levels) may be activated by inserting a regulatory element which is capable of promoting the expression of a normally expressed gene product in that cell. Techniques such as targeted homologous recombinations, can be used to insert the heterologous DNA as described in, e.g., Chappel, U.S. Pat. No. 5,272,071; WO 91/06667, published on May 16, 1991.
Transgenic Animals
Non-human transgenic animals that express a heterologous ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide (e.g., expressed from a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid isolated from another organism) can be generated. Such animals are useful for studying the function and/or activity of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide and for identifying and/or evaluating modulators of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid and ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide activity. As used herein, a “transgenic animal” is a non-human animal such as a mammal (e.g., a non-human primate such as chimpanzee, baboon, or macaque; an ungulate such as an equine, bovine, or caprine; or a rodent such as a rat, a mouse, or an Israeli sand rat), a bird (e.g., a chicken or a turkey), an amphibian (e.g., a frog, salamander, or newt), or an insect (e.g., Drosophila melanogaster), in which one or more of the cells of the animal includes a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 transgene. A transgene is exogenous DNA or a rearrangement (e.g., a deletion of endogenous chromosomal DNA) that is often integrated into or occurs in the genome of cells in a transgenic animal. A transgene can direct expression of an encoded gene product in one or more cell types or tissues of the transgenic animal, and other transgenes can reduce expression (e.g., a knockout). Thus, a transgenic animal can be one in which an endogenous ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 gene has been altered by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell of the animal (e.g., an embryonic cell of the animal) prior to development of the animal.
Intronic sequences and polyadenylation signals can also be included in the transgene to increase expression efficiency of the transgene. One or more tissue-specific regulatory sequences can be operably linked to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 transgene to direct expression of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide to particular cells. A transgenic founder animal can be identified based upon the presence of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 transgene in its genome and/or expression of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene encoding a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide can further be bred to other transgenic animals carrying other transgenes.
ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides can be expressed in transgenic animals or plants by introducing, for example, a nucleic acid encoding the polypeptide into the genome of an animal. In certain embodiments the nucleic acid is placed under the control of a tissue specific promoter, e.g., a milk or egg specific promoter, and recovered from the milk or eggs produced by the animal. Also included is a population of cells from a transgenic animal.
ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 Polypeptides
Featured herein are isolated ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides, which include polypeptides having amino acid sequences set forth in SEQ ID NO: 18-27, and substantially identical polypeptides thereof. Such polypeptides sometimes are proteins or peptides. A ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide is a polypeptide encoded by a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid, where one nucleic acid can encode one or more different polypeptides. An “isolated” or “purified” polypeptide or protein is substantially free of cellular material or other contaminating proteins from the cell or tissue source from which the protein is derived, or substantially free from chemical precursors or other chemicals when chemically synthesized. In one embodiment, the language “substantially free” means preparation of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide variant having less than about 30%, 20%, 10% and sometimes 5% (by dry weight), of non-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide (also referred to herein as a “contaminating protein”), or of chemical precursors or non-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 chemicals. When the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or a biologically active portion thereof is recombinantly produced, it is also often substantially free of culture medium, specifically, where culture medium represents less than about 20%, sometimes less than about 10%, and often less than about 5% of the volume of the polypeptide preparation. Isolated or purified ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide preparations are sometimes 0.01 milligrams or more or 0.1 milligrams or more, and often 1.0 milligrams or more and 10 milligrams or more in dry weight. In specific embodiments, a polypeptide comprises leucine at amino acid position 359 in SEQ ID NO: 23, a leucine at amino acid position 378 in SEQ ID NO: 23, an alanine at amino acid position 857 in SEQ ID NO: 23, an alanine at position 902 in SEQ ID NO: 23 a proline at amino acid position 352 in SEQ ID NO: 20 and/or an alanine at amino acid position 348 in SEQ ID NO: 20. A polypeptide encoded by a nucleotide sequence in a NUMA1 region (e.g., NUMA1 polypeptide (e.g., SEQ ID NO: 24), FLJ20625 polypeptide (e.g., accession no. NM—0L7907) and IL18BP polypeptide (e.g., accession nos. NM—173042, NM—173043 or NM—173044)) sometimes includes one or more of the following amino acid variations: a leucine at a position corresponding to amino acid position 73 in an NM—017907 polypeptide, a glutamine at a position corresponding to amino acid position 772 in SEQ ID NO: 24, a glutamate at a position corresponding to amino acid position 873 in SEQ ID NO: 24, a glycine at a position corresponding to amino acid position 794 in SEQ ID NO: 24, an arginine at a position corresponding to amino acid position 89 in an IL18BP polypeptide, an argenine at a position corresponding to amino acid position 119 in an IL18BP polypeptide, a cysteine at a position corresponding to amino acid position 195 in a IL18BP polypeptide, an alanine at a position corresponding to amino acid position 2049 in SEQ ID NO: 24, a methionine at a position corresponding to amino acid position 1825 in SEQ ID NO: 24, and a glycine at a position corresponding to amino acid position 978 in SEQ ID NO: 24. A polypeptide encoded by a nucleotide sequence in a GALE region (e.g., GALE (e.g., SEQ ID NO: 25), TCEB3 (e.g., accession no. NM—003198) and HT014 (e.g., accession no. NM—020362)) sometimes includes one or more of the following amino acid variations: a valine at a position corresponding to amino acid position 298 in a TCEB3 polypeptide, a valine at a position corresponding to amino acid position 490 in a TCEB3 polypeptide, a methionine at a position corresponding to amino acid position 119 in a TCEB3 polypeptide, a glycine at a position corresponding to amino acid position 227 in SEQ ID NO: 25, an aspartate at a position corresponding to amino acid position 231 in SEQ ID NO: 25, an asparagine at a position corresponding to amino acid position 268 in SEQ ID NO: 25, a valine at a position corresponding to amino acid position 283 in SEQ ID NO: 25, a leucine at a position corresponding to amino acid position 215 in SEQ ID NO: 25, a glycine at a position corresponding to amino acid position 235 in SEQ ID NO: 25, a glutamate at a position corresponding to amino acid position 331 in SEQ ID NO: 25, a serine at a position corresponding to amino acid position 191 in a HT014 polypeptide and a tyrosine at a position corresponding to amino acid position 141 in SEQ ID NO: 25.
In another aspect, featured herein are ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides and biologically active or antigenic fragments thereof that are useful as reagents or targets in assays applicable to prevention, treatment or diagnosis of breast cancer. In another embodiment, provided herein are ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides having a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activity or activities.
Further included herein are ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide fragments. The polypeptide fragment may be a domain or part of a domain of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. The polypeptide fragment is often 50 or fewer, 100 or fewer, or 200 or fewer amino acids in length, and is sometimes 300, 400, 500, 600, 700, or 900 or fewer amino acids in length. In certain embodiments, the polypeptide fragment comprises, consists essentially of, or consists of, at least 6 consecutive amino acids and not more than 121I consecutive amino acids of SEQ ID NO: 18-27, or the polypeptide fragment comprises, consists essentially of, or consists of, at least 6 consecutive amino acids and not more than 543 consecutive amino acids of SEQ ID NO: 18-27.
ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides described herein can be used as immunogens to produce anti-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 antibodies in a subject, to purify ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 ligands or binding partners, and in screening assays to identify molecules which inhibit or enhance the interaction of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 with a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 substrate. Full-length ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides and polynucleotides encoding the same may be specifically substituted for a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide fragment or polynucleotide encoding the same in any embodiment described herein.
Substantially identical polypeptides may depart from the amino acid sequences set forth in SEQ ID NO: 18-27 in different manners. For example, conservative amino acid modifications may be introduced at one or more positions in the amino acid sequences of SEQ ID NO: 18-27. A “conservative amino acid substitution” is one in which the amino acid is replaced by another amino acid having a similar structure and/or chemical function. Families of amino acid residues having similar structures and functions are well known. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Also, essential and non-essential amino acids may be replaced. A “non-essential” amino acid is one that can be altered without abolishing or substantially altering the biological function of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide, whereas altering an “essential” amino acid abolishes or substantially alters the biological function of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. Amino acids that are conserved among ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides are typically essential amino acids.
Also, ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides and polypeptide variants may exist as chimeric or fusion polypeptides. As used herein, a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 “chimeric polypeptide” or “fusion polypeptide” includes a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide linked to a non-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. A “non-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide” refers to a polypeptide having an amino acid sequence corresponding to a polypeptide which is not substantially identical to the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide, which includes, for example, a polypeptide that is different from the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide and derived from the same or a different organism. The ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide in the fusion polypeptide can correspond to an entire or nearly entire ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or a fragment thereof. The non-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide can be fused to the N-terminus or C-terminus of the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide.
Fusion polypeptides can include a moiety having high affinity for a ligand. For example, the fusion polypeptide can be a GST-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 fusion polypeptide in which the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 sequences are fused to the C-terminus of the GST sequences, or a polyhistidine-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 fusion polypeptide in which the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide is fused at the N- or C-terminus to a string of histidine residues. Such fusion polypeptides can facilitate purification of recombinant ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197. Expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide), and a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid can be cloned into an expression vector such that the fusion moiety is linked in-frame to the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. Further, the fusion polypeptide can be a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide containing a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), expression, secretion, cellular internalization, and cellular localization of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide can be increased through use of a heterologous signal sequence. Fusion polypeptides can also include all or a part of a serum polypeptide (e.g., an IgG constant region or human serum albumin).
ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197polypeptides or fragments thereof can be incorporated into pharmaceutical compositions and administered to a subject in vivo. Administration of these ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides can be used to affect the bioavailability of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 substrate and may effectively increase or decrease ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 biological activity in a cell or effectively supplement dysfunctional or hyperactive ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 fusion polypeptides may be useful therapeutically for the treatment of disorders caused by, for example, (i) aberrant modification or mutation of a gene encoding a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide; (ii) mis-regulation of the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 gene; and (iii) aberrant post-translational modification of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. Also, ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides can be used as immunogens to produce anti-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 antibodies in a subject, to purify ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 ligands or binding partners, and in screening assays to identify molecules which inhibit or enhance the interaction of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 with a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 substrate.
In addition, polypeptides can be chemically synthesized using techniques known in the art (See, e.g., Creighton, 1983 Proteins. New York, N.Y.: W.H. Freeman and Company; and Hunkapiller et al., (1984) Nature July 12-18; 310(5973): 105-11). For example, a relative short polypeptide fragment can be synthesized by use of a peptide synthesizer. Furthermore, if desired, non-classical amino acids or chemical amino acid analogs can be introduced as a substitution or addition into the fragment sequence. Non-classical amino acids include, but are not limited to, to the D-isomers of the common amino acids, 2,4-diaminobutyric acid, a-amino isobutyric acid, 4-aminobutyric acid, Abu, 2-amino butyric acid, g-Abu, e-Ahx, 6-amino hexanoic acid, Aib, 2-amino isobutyric acid, 3-amino propionic acid, ornithine, norleucine, norvaline, hydroxyproline, sarcosine, citrulline, homocitrulline, cysteic acid, t-butylglycine, t-butylalanine, phenylglycine, cyclohexylalanine, b-alanine, fluoroamino acids, designer amino acids such as b-methyl amino acids, Ca-methyl amino acids, Na-methyl amino acids, and amino acid analogs in general. Furthermore, the amino acid can be D (dextrorotary) or L (levorotary).
Also included are polypeptide fragments which are differentially modified during or after translation, e.g., by glycosylation, acetylation, phosphorylation, amidation, derivatization by known protecting/blocking groups, proteolytic cleavage, linkage to an antibody molecule or other cellular ligand, and the like. Any of numerous chemical modifications may be carried out by known techniques, including but not limited, to specific chemical cleavage by cyanogen bromide, trypsin, chymotrypsin, papain, V8 protease, NaBH4; acetylation, formylation, oxidation, reduction; metabolic synthesis in the presence of tunicamycin; and the like.
Additional post-translational modifications include, for example, N-linked or O-linked carbohydrate chains, processing of N-terminal or C-terminal ends), attachment of chemical moieties to the amino acid backbone, chemical modifications of N-linked or O-linked carbohydrate chains, and addition or deletion of an N-terminal methionine residue as a result of prokaryotic host cell expression. The polypeptide fragments may also be modified with a detectable label, such as an enzymatic, fluorescent, isotopic or affinity label to allow for detection and isolation of the polypeptide.
Also provided are chemically modified polypeptide derivatives that may provide additional advantages such as increased solubility, stability and circulating time of the polypeptide, or decreased immunogenicity. See U.S. Pat. No. 4,179,337. The chemical moieties for derivitization may be selected from water soluble polymers such as polyethylene glycol, ethylene glycol/propylene glycol copolymers, carboxymethylcellulose, dextran, polyvinyl alcohol and the like. The polypeptides may be modified at random positions within the molecule, or at predetermined positions within the molecule and may include one, two, three or more attached chemical moieties.
The polymer may be of any molecular weight, and may be branched or unbranched. For polyethylene glycol, the molecular weight is between about 1 kDa and about 100 kDa (the term “about” indicating that in preparations of polyethylene glycol, some molecules will weigh more, some less, than the stated molecular weight) for ease in handling and manufacturing. Other sizes may be used, depending on the desired therapeutic profile (e.g., the duration of sustained release desired, the effects, if any on biological activity, the ease in handling, the degree or lack of antigenicity and other known effects of the polyethylene glycol to a therapeutic protein or analog).
The polyethylene glycol molecules (or other chemical moieties) should be attached to the polypeptide with consideration of effects on functional or antigenic domains of the polypeptide. There are a number of attachment methods available to those skilled in the art, e.g., EP 0 401 384, herein incorporated by reference (coupling PEG to G-CSF), see also Malik et al. (1992) Exp Hematol. September; 20 (8): 1028-35, reporting pegylation of GM-CSF using tresyl chloride). For example, polyethylene glycol may be covalently bound through amino acid residues via a reactive group, such as, a free amino or carboxyl group. Reactive groups are those to which an activated polyethylene glycol molecule may be bound. The amino acid residues having a free amino group may include lysine residues and the N-terminal amino acid residues; those having a free carboxyl group may include aspartic acid residues, glutamic acid residues and the C-terminal amino acid residue. Sulfhydryl groups may also be used as a reactive group for attaching the polyethylene glycol molecules. A polymer sometimes is attached at an amino group, such as attachment at the N-terminus or lysine group.
One may specifically desire proteins chemically modified at the N-terminus. Using polyethylene glycol as an illustration of the present composition, one may select from a variety of polyethylene glycol molecules (by molecular weight, branching, and the like), the proportion of polyethylene glycol molecules to protein (polypeptide) molecules in the reaction mix, the type of pegylation reaction to be performed, and the method of obtaining the selected N-terminally pegylated protein. The method of obtaining the N-terminally pegylated preparation (i.e., separating this moiety from other monopegylated moieties if necessary) may be by purification of the N-terminally pegylated material from a population of pegylated protein molecules. Selective proteins chemically modified at the N-terminus may be accomplished by reductive alkylation, which exploits differential reactivity of different types of primary amino groups (lysine versus the N-terminal) available for derivatization in a particular protein. Under the appropriate reaction conditions, substantially selective derivatization of the protein at the N-terminus with a carbonyl group containing polymer is achieved.
Substantially Identical Nucleic Acids and Polypeptides
Nucleotide sequences and polypeptide sequences that are substantially identical to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence and the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide sequences encoded by those nucleotide sequences are included herein. The term “substantially identical” as used herein refers to two or more nucleic acids or polypeptides sharing one or more identical nucleotide sequences or polypeptide sequences, respectively. Included are nucleotide sequences or polypeptide sequences that are 55% or more, 60% or more, 65% or more, 70% or more, 75% or more, 80% or more, 85% or more, 90% or more, 95% or more (each often within a 1%, 2%, 3% or 4% variability) or more identical to the nucleotide sequences in SEQ ID NO: 1-17 or the encoded ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide amino acid sequences. One test for determining whether two nucleic acids are substantially identical is to determine the percent of identical nucleotide sequences or polypeptide sequences shared between the nucleic acids or polypeptides.
Calculations of sequence identity are often performed as follows. Sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). The length of a reference sequence aligned for comparison purposes is sometimes 30% or more, 40% or more, 50% or more, often 60% or more, and more often 70% or more, 80% or more, 90% or more, 90% or more, or 100% of the length of the reference sequence. The nucleotides or amino acids at corresponding nucleotide or polypeptide positions, respectively, are then compared among the two sequences. When a position in the first sequence is occupied by the same nucleotide or amino acid as the corresponding position in the second sequence, the nucleotides or amino acids are deemed to be identical at that position. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, introduced for optimal alignment of the two sequences.
Comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. Percent identity between two amino acid or nucleotide sequences can be determined using the algorithm of Meyers & Miller, CABIOS 4: 11-17 (1989), which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4. Also, percent identity between two amino acid sequences can be determined using the Needleman & Wunsch, J. Mol. Biol. 48: 444-453 (1970) algorithm which has been incorporated into the GAP program in the GCG software package (available at the http address www.gcg.com), using either a Blossum 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6. Percent identity between two nucleotide sequences can be determined using the GAP program in the GCG software package (available at http address www.gcg.com), using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, 4, 5, or 6. A set of parameters often used is a Blossum 62 scoring matrix with a gap open penalty of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5.
Another manner for determining if two nucleic acids are substantially identical is to assess whether a polynucleotide homologous to one nucleic acid will hybridize to the other nucleic acid under stringent conditions. As use herein, the term “stringent conditions” refers to conditions for hybridization and washing. Stringent conditions are known to those skilled in the art and can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y., 6.3.1-6.3.6 (1989). Aqueous and non-aqueous methods are described in that reference and either can be used. An example of stringent hybridization conditions is hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 50° C. Another example of stringent hybridization conditions are hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 55° C. A further example of stringent hybridization conditions is hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 60° C. Often, stringent hybridization conditions are hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 65° C. More often, stringency conditions are 0.5M sodium phosphate, 7% SDS at 65° C., followed by one or more washes at 0.2×SSC, 1% SDS at 65° C.
An example of a substantially identical nucleotide sequence to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence is one that has a different nucleotide sequence but still encodes the same polypeptide sequence encoded by the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence. Another example is a nucleotide sequence that encodes a polypeptide having a polypeptide sequence that is more than 70% or more identical to, sometimes 75% or more, 80% or more, or 85% or more identical to, and often 90% or more and 95% or more identical to a polypeptide sequence encoded by a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence.
ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequences and ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 amino acid sequences can be used as “query sequences” to perform a search against public databases to identify other family members or related sequences, for example. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul et al., J. Mol. Biol. 215: 403-10 (1990). BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to nucleotide sequences from SEQ ID NO: 1-17. BLAST polypeptide searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to polypeptides encoded by a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al., Nucleic Acids Res. 25(17): 3389-3402 (1997). When utilizing BLAST and Gapped BLAST programs, default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used (see the http address www.ncbi.nlm.nih.gov).
A nucleic acid that is substantially identical to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence may include polymorphic sites at positions equivalent to those described herein when the sequences are aligned. For example, using the alignment procedures described herein, SNPs in a sequence substantially identical to a sequence in SEQ ID NO: 1-17 can be identified at nucleotide positions that match (i.e., align) with nucleotides at SNP positions in the nucleotide sequence of SEQ ID NO: 1-17. Also, where a polymorphic variation results in an insertion or deletion, insertion or deletion of a nucleotide sequence from a reference sequence can change the relative positions of other polymorphic sites in the nucleotide sequence.
Substantially identical nucleotide and polypeptide sequences include those that are naturally occurring, such as allelic variants (same locus), splice variants, homologs (different locus), and orthologs (different organism) or can be non-naturally occurring. Non-naturally occurring variants can be generated by mutagenesis techniques, including those applied to polynucleotides, cells, or organisms. The variants can contain nucleotide substitutions, deletions, inversions and insertions. Variation can occur in either or both the coding and non-coding regions. The variations can produce both conservative. and non-conservative amino acid substitutions (as compared in the encoded product). Orthologs, homologs, allelic variants, and splice variants can be identified using methods known in the art. These variants normally comprise a nucleotide sequence encoding a polypeptide that is 50% or more, about 55% or more, often about 70-75% or more, more often about 80-85% or more, and typically about 90-95% or more identical to the amino acid sequences of target polypeptides or a fragment thereof. Such nucleic acid molecules readily can be identified as being able to hybridize under stringent conditions to a nucleotide sequence in SEQ ID NO: 1-17 or a fragment thereof. Nucleic acid molecules corresponding to orthologs, homologs, and allelic variants of a nucleotide sequence in SEQ ID NO: 1-17 can be identified by mapping the sequence to the same chromosome or locus as the nucleotide sequence in SEQ ID NO: 1-17.
Also, substantially identical nucleotide sequences may include codons that are altered with respect to the naturally occurring sequence for enhancing expression of a target polypeptide in a particular expression system. For example, the nucleic acid can be one in which one or more codons are altered, and often 10% or more or 20% or more of the codons are altered for optimized expression in bacteria (e.g., E. coli), yeast (e.g., S. cervesiae), human (e.g., 293 cells), insect, or rodent (e.g., hamster) cells.
Methods for Identifying Subjects at Risk of Breast Cancer and Breast Cancer Risk in a Subject
Methods for prognosing and diagnosing breast cancer in subjects are provided herein. These methods include detecting the presence or absence of one or more polymorphic variations associated with breast cancer in a nucleotide sequence set forth in SEQ ID NO: 1-7, or substantially identical sequence thereof, in a sample from a subject, where the presence of a polymorphic variant is indicative of a risk of breast cancer.
Thus, featured herein is a method for detecting a subject at risk of breast cancer or the risk of breast cancer in a subject, which comprises detecting the presence or absence of a polymorphic variation associated with breast cancer at a polymorphic site in a nucleic acid sample from a subject, where the nucleotide sequence comprises a polynucleotide sequence selected from the group consisting of: (a) a nucleotide sequence set forth in SEQ ID NO: 1-7; (b) a nucleotide sequence which encodes a polypeptide having an amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-7; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-7 or a nucleotide sequence about 90% or more identical to the nucleotide sequence set forth in SEQ ID NO: 1-7; and (d) a fragment of a nucleotide sequence of (a), (b), or (c), often a fragment that includes a polymorphic site associated with breast cancer; whereby the presence of the polymorphic variation is indicative of a risk of breast cancer in the subject. In certain embodiments, the polymorphic variant is detected at a position described herein. The term “SEQ ID NO: 1-7” as used herein refers to one or more of SEQ ID NO: 1, 2, 3, 4, 5, 6 or 7.
In certain embodiments, determining the presence of a combination of two or more polymorphic variants associated with breast cancer in one or more genetic loci (e.g., one or more genes) of the sample is determined to identify, quantify and/or estimate, risk of breast cancer. The risk often is the probability of having or developing breast cancer. The risk sometimes is expressed as a relative risk with respect to a population average risk of breast cancer, and sometimes is expressed as a relative risk with resepect to the lowest risk group. Such relative risk assessments often are based upon penetrance values determined by statistical methods (see e.g., statistical analysis Example 9), and are particularly useful to clinicians and insurance companies for assessing risk of breast cancer (e.g., a clinician can target appropriate detection, prevention and therapeutic regimens to a partient after determining the patient's risk of breast cancer, and an insurance company can fine tune actuarial tables based upon population genotype assessments of breast cancer risk). Risk of breast cancer sometimes is expressed as an odds ratio, which is the odds of a particular person having a genotype has or will develop breast cancer with respect to another genotype group (e.g., the most disease protective genotype or population average). In related embodiments, the determination is utilized to identify a subject at risk of breast cancer. In an embodiment, two or more polymorphic variations are detected in two or more regions in human genomic DNA associated with increased risk of breast cancer, such as regions selected from the group of loci consisting of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197, for example. In certain embodiments, 3 or more, or 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 or more polymorphic variants are detected in the sample. In specific embodiments, polymorphic variants are detected in ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 loci, such as at positions 44247 in SEQ ID NO: 1 (ICAM), position 36424 in SEQ ID NO: 2 (MAPK10), position 48563 in SEQ ID NO: 3 (KIAA0861), position 49002 in SEQ ID NO: 4 (NUMA1) and position 174 in SEQ ID NO: 5 (GALE), for example. In certain embodiments, polymorphic variants are detected at other genetic loci (e.g., the polymorphic variants can be detected in ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and/or LOC145197 in addition to other loci or only in other loci), where the other loci include but are not limited to RAD21, KLF12, SPUVE, GRIN3A, PFTK1, SERPINA5, LOC115209, HRMT1L3, DLG1, KIAA0783, DPF3, CENPC1, GP6, LAMA4, CHCB/C20ORF154, LOC338749, and TTN/LOC351327, which are described in patent applications Nos. 10/723,670, 10/723,518, 10/722,939 and 10/723,683, having attorney docket numbers524592006700, 524592006800, 524592007100 and 524592007200, respectively, and any others disclosed in patent application Nos. 60/429,136 (filed Nov. 25, 2002) and 60/490,234 (filed Jul. 24, 2003).
A risk of developing aggressive forms of breast cancer likely to metastasize or invade surrounding tissues (e.g., Stage IIIA, IIIB, and IV breast cancers), and subjects at risk of developing aggressive forms of breast cancer also may be identified by the methods described herein. These methods include collecting phenotype information from subjects having breast cancer, which includes the stage of progression of the breast cancer, and performing a secondary phenotype analysis to detect the presence or absence of one or more polymorphic variations associated with a particular stage form of breast cancer. Thus, detecting the presence or absence of one or more polymorphic variations in a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence associated with a late stage form of breast cancer often is prognostic and/or diagnostic of an aggressive form of the cancer.
Results from prognostic tests may be combined with other test results to diagnose breast cancer. For example, prognostic results may be gathered, a patient sample may be ordered based on a determined predisposition to breast cancer, the patient sample is analyzed, and the results of the analysis may be utilized to diagnose breast cancer. Also breast cancer diagnostic methods can be developed from studies used to generate prognostic/diagnostic methods in which populations are stratified into subpopulations having different progressions of breast cancer. In another embodiment, prognostic results may be gathered; a patient's risk factors for developing breast cancer analyzed (e.g., age, race, family history, age of first menstrual cycle, age at birth of first child); and a patient sample may be ordered based on a determined predisposition to breast cancer. In an alternative embodiment, the results from predisposition analyses described herein may be combined with other test results indicative of breast cancer, which were previously, concurrently, or subsequently gathered with respect to the predisposition testing. In these embodiments, the combination of the prognostic test results with other test results can be probative of breast cancer, and the combination can be utilized as a breast cancer diagnostic. The results of any test indicative of breast cancer known in the art may be combined with the methods described herein. Examples of such tests are mammography (e.g., a more frequent and/or earlier mammography regimen may be prescribed); breast biopsy and optionally a biopsy from another tissue; breast ultrasound and optionally an ultrasound analysis of another tissue; breast magnetic resonance imaging (MRI) and optionally an MRI analysis of another tissue; electrical impedance (T-scan) analysis of breast and optionally of another tissue; ductal lavage; nuclear medicine analysis (e.g., scintimammography); BRCA1 and/or BRCA2 sequence analysis results; and thermal imaging of the breast and optionally of another tissue. Testing may be performed on tissue other than breast to diagnose the occurrence of metastasis (e.g., testing of the lymph node).
Risk of breast cancer sometimes is expressed as a probability, such as an odds ratio, percentage, or risk factor. The risk is based upon the presence or absence of one or more polymorphic variants described herein, and also may be based in part upon phenotypic traits of the individual being tested. Methods for calculating predispositions based upon patient data are well known (see, e.g., Agresti, Categorical Data Analysis, 2nd Ed. 2002. Wiley). Allelotyping and genotyping analyses may be carried out in populations other than those exemplified herein to enhance the predictive power of the prognostic method. These further analyses are executed in view of the exemplified procedures described herein, and may be based upon the same polymorphic variations or additional polymorphic variations. Risk determinations for breast cancer are useful in a variety of applications. In one embodiment, breast cancer risk determinations are used by clinicians to direct appropriate detection, preventative and treatment procedures to subjects who most require these. In another embodiment, breast cancer risk determinations are used by health insurers for preparing actuarial tables and for calculating insurance premiums.
The nucleic acid sample typically is isolated from a biological sample obtained from a subject. For example, nucleic acid can be isolated from blood, saliva, sputum, urine, cell scrapings, and biopsy tissue. The nucleic acid sample can be isolated from a biological sample using standard techniques, such as the technique described in Example 2. As used herein, the term “subject” refers primarily to humans but also refers to other mammals such as dogs, cats, and ungulates (e.g., cattle, sheep, and swine). Subjects also include avians (e.g., chickens and turkeys), reptiles, and fish (e.g., salmon), as embodiments described herein can be adapted to nucleic acid samples isolated from any of these organisms. The nucleic acid sample may be isolated from the subject and then directly utilized in a method for determining the presence of a polymorphic variant, or alternatively, the sample may be isolated and then stored (e.g., frozen) for a period of time before being subjected to analysis.
The presence or absence of a polymorphic variant is determined using one or both chromosomal complements represented in the nucleic acid sample. Determining the presence or absence of a polymorphic variant in both chromosomal complements represented in a nucleic acid sample from a subject having a copy of each chromosome is useful for determining the zygosity of an individual for the polymorphic variant (i.e., whether the individual is homozygous or heterozygous for the polymorphic variant). Any oligonucleotide-based diagnostic may be utilized to determine whether a sample includes the presence or absence of a polymorphic variant in a sample. For example, primer extension methods, ligase sequence determination methods (e.g., U.S. Pat. Nos. 5,679,524 and 5,952,174, and WO 01/27326), mismatch sequence determination methods (e.g., U.S. Pat. Nos. 5,851,770; 5,958,692; 6,110,684; and 6,183,958), microarray sequence determination methods, restriction fragment length polymorphism (RFLP), single strand conformation polymorphism detection (SSCP) (e.g., U.S. Pat. Nos. 5,891,625 and 6,013,499), PCR-based assays (e.g., TAQMAN® PCR System (Applied Biosystems)), and nucleotide sequencing methods may be used.
Oligonucleotide extension methods typically involve providing a pair of oligonucleotide primers in a polymerase chain reaction (PCR) or in other nucleic acid amplification methods for the purpose of amplifying a region from the nucleic acid sample that comprises the polymorphic variation. One oligonucleotide primer is complementary to a region 3′ of the polymorphism and the other is complementary to a region 5′ of the polymorphism. A PCR primer pair may be used in methods disclosed in U.S. Pat. Nos. 4,683,195; 4,683,202, 4,965,188; 5,656,493; 5,998,143; 6,140,054; WO 01/27327; and WO 01/27329 for example. PCR primer pairs may also be used in any commercially available machines that perform PCR, such as any of the GENEAMP® Systems available from Applied Biosystems. Also, those of ordinary skill in the art will be able to design oligonucleotide primers based upon a nucleotide sequence set forth in SEQ ID NO: 1-7 without undue experimentation using knowledge readily available in the art.
Also provided is an extension oligonucleotide that hybridizes to the amplified fragment adjacent to the polymorphic variation. As used herein, the term “adjacent” refers to the 3′ end of the extension oligonucleotide being often 1 nucleotide from the 5′ end of the polymorphic site, and sometimes 2, 3, 4, 5, 6, 7, 8, 9, or 10 nucleotides from the 5′ end of the polymorphic site, in the nucleic acid when the extension oligonucleotide is hybridized to the nucleic acid. The extension oligonucleotide then is extended by one or more nucleotides, and the number and/or type of nucleotides that are added to the extension oligonucleotide determine whether the polymorphic variant is present. Oligonucleotide extension methods are disclosed, for example, in U.S. Pat. Nos. 4,656,127; 4,851,331; 5,679,524; 5,834,189; 5,876,934; 5,908,755; 5,912,118; 5,976,802; 5,981,186; 6,004,744; 6,013,431; 6,017,702; 6,046,005; 6,087,095; 6,210,891; and WO 01/20039. Oligonucleotide extension methods using mass spectrometry are described, for example, in U.S. Pat. Nos. 5,547,835; 5,605,798; 5,691,141; 5,849,542; 5,869,242; 5,928,906; 6,043,031; and 6,194,144, and a method often utilized is described herein in Example 2. Multiple extension oligonucleotides may be utilized in one reaction, which is referred to herein as “multiplexing.”
A microarray can be utilized for determining whether a polymorphic variant is present or absent in a nucleic acid sample. A microarray may include any oligonucleotides described herein, and methods for making and using oligonucleotide microarrays suitable for diagnostic use are disclosed in U.S. Pat. Nos. 5,492,806; 5,525,464; 5,589,330; 5,695,940; 5,849,483; 6,018,041; 6,045,996; 6,136,541; 6,142,681; 6,156,501; 6,197,506; 6,223,127; 6,225,625; 6,229,911; 6,239,273; WO 00/52625; WO 01/25485; and WO 01/29259. The microarray typically comprises a solid support and the oligonucleotides may be linked to this solid support by covalent bonds or by non-covalent interactions. The oligonucleotides may also be linked to the solid support directly or by a spacer molecule. A microarray may comprise one or more oligonucleotides complementary to a polymorphic site set forth in SEQ ID NO: 1-7 or below.
A kit also may be utilized for determining whether a polymorphic variant is present or absent in a nucleic acid sample. A kit often comprises one or more pairs of oligonucleotide primers useful for amplifying a fragment of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence or a substantially identical sequence thereof, where the fragment includes a polymorphic site. The kit sometimes comprises a polymerizing agent, for example, a thermostable nucleic acid polymerase such as one disclosed in U.S. Pat. No. 4,889,818 or 6,077,664. Also, the kit often comprises an elongation oligonucleotide that hybridizes to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence in a nucleic acid sample adjacent to the polymorphic site. Where the kit includes an elongation oligonucleotide, it also often comprises chain elongating nucleotides, such as dATP, dTTP, dGTP, dCTP, and dTTP, including analogs of dATP, dTTP, dGTP, dCTP and dTTP, provided that such analogs are substrates for a thermostable nucleic acid polymerase and can be incorporated into a nucleic acid chain elongated from the extension oligonucleotide. Along with chain elongating nucleotides would be one or more chain terminating nucleotides such as ddATP, ddTTP, ddGTP, ddCTP, and the like. In an embodiment, the kit comprises one or more oligonucleotide primer pairs, a polymerizing agent, chain elongating nucleotides, at least one elongation oligonucleotide, and one or more chain terminating nucleotides. Kits optionally include buffers, vials, microtiter plates, and instructions for use.
An individual identified as being at risk of breast cancer may be heterozygous or homozygous with respect to the allele associated with a higher risk of breast cancer. A subject homozygous for an allele associated with an increased risk of breast cancer is at a comparatively high risk of breast cancer, a subject heterozygous for an allele associated with an increased risk of breast cancer is at a comparatively intermediate risk of breast cancer, and a subject homozygous for an allele associated with a decreased risk of breast cancer is at a comparatively low risk of breast cancer. A genotype may be assessed for a complementary strand, such that the complementary nucleotide at a particular position is detected.
Also featured are methods for determining risk of breast cancer and/or identifying a subject at risk of breast cancer by contacting a polypeptide or protein encoded by a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence from a subject with an antibody that specifically binds to an epitope associated with increased risk of breast cancer in the polypeptide. In certain embodiments, the antibody specifically binds to an epitope that comprises a leucine at amino acid position 359 in SEQ ID NO: 23, a leucine at amino acid position 378 in SEQ ID NO: 23, an alanine at amino acid position 857 in SEQ ID NO: 23, an alanine at position 902 in SEQ ID NO: 23 a proline at amino acid position 352 in SEQ ID NO: 20 or an alanine at amino acid position 348 in SEQ ID NO: 20.
Applications of Prognostic and Diagnostic Results to Pharmacogenomic Methods
Pharmacogenomics is a discipline that involves tailoring a treatment for a subject according to the subject's genotype. For example, based upon the outcome of a prognostic test described herein, a clinician or physician may target pertinent information and preventative or therapeutic treatments to a subject who would be benefited by the information or treatment and avoid directing such information and treatments to a subject who would not be benefited (e.g., the treatment has no therapeutic effect and/or the subject experiences adverse side effects). As therapeutic approaches for breast cancer continue to evolve and improve, the goal of treatments for breast cancer related disorders is to intervene even before clinical signs (e.g., identification of lump in the breast) first manifest. Thus, genetic markers associated with susceptibility to breast cancer prove useful for early diagnosis, prevention and treatment of breast cancer.
The following is an example of a pharmacogenomic embodiment. A particular treatment regimen can exert a differential effect depending upon the subject's genotype. Where a candidate therapeutic exhibits a significant interaction with a major allele and a comparatively weak interaction with a minor allele (e.g., an order of magnitude or greater difference in the interaction), such a therapeutic typically would not be administered to a subject genotyped as being homozygous for the minor allele, and sometimes not administered to a subject genotyped as being heterozygous for the minor allele. In another example, where a candidate therapeutic is not significantly toxic when administered to subjects who are homozygous for a major allele but is comparatively toxic when administered to subjects heterozygous or homozygous for a minor allele, the candidate therapeutic is not typically administered to subjects who are genotyped as being heterozygous or homozygous with respect to the minor allele.
The methods described herein are applicable to pharmacogenomic methods for detecting, preventing, alleviating and/or treating breast cancer. For example, a nucleic acid sample from an individual may be subjected to a genetic test described herein. Where one or more polymorphic variations associated with increased risk of breast cancer are identified in a subject, information for detecting, preventing or treating breast cancer and/or one or more breast cancer detection, prevention and/or treatment regimens then may be directed to and/or prescribed to that subject.
In certain embodiments, a detection, prevenative and/or treatment regimen is specifically prescribed and/or administered to individuals who will most benefit from it based upon their risk of developing breast cancer assessed by the methods described herein. Thus, provided are methods for identifying a subject at risk of breast cancer and then prescribing a detection, therapeutic or preventative regimen to individuals identified as being at risk of breast cancer. Thus, certain embodiments are directed to methods for treating breast cancer in a subject, reducing risk of breast cancer in a subject, or early detection of breast cancer in a subject, which comprise: detecting the presence or absence of a polymorphic variant associated with breast cancer in a nucleotide sequence in a nucleic acid sample from a subject, where the nucleotide sequence comprises a polynucleotide sequence selected from the group consisting of: (a) a nucleotide sequence set forth in SEQ ID NO: 1-7; (b) a nucleotide sequence which encodes a polypeptide having an amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-7; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-7 or a nucleotide sequence about 90% or more identical to the nucleotide sequence set forth in SEQ ID NO: 1-7; and (d) a fragment of a nucleotide sequence of (a), (b), or (c), sometimes comprising a polymorphic site associated with breast cancer; and prescribing or administering a breast cancer treatment regimen, preventative regimen and/or detection regimen to a subject from whom the sample originated where the presence of one or more polymorphic variations associated with breast cancer are detected in the nucleotide sequence. In these methods, genetic results may be utilized in combination with other test results to diagnose breast cancer as described above. Other test results include but are not limited to mammography results, imaging results, biopsy results and results from BRCA1 or BRAC2 test results, as described above.
Detection regimens include one or more mammography procedures, a regular mammography regimen (e.g., once a year, or once every six, four, three or two months); an early mammography regimen (e.g., mammography tests are performed beginning at age 25, 30, or 35); one or more biopsy procedures (e.g., a regular biopsy regimen beginning at age 40); breast biopsy and biopsy from other tissue; breast ultrasound and optionally ultrasound analysis of another tissue; breast magnetic resonance imaging (MRI) and optionally MRI analysis of another tissue; electrical impedance (T-scan) analysis of breast and optionally another tissue; ductal lavage; nuclear medicine analysis (e.g., scintimammography); BRCA1 and/or BRCA2 sequence analysis results; and/or thermal imaging of the breast and optionally another tissue.
Treatments sometimes are preventative (e.g., is prescribed or administered to reduce the probability that a breast cancer associated condition arises or progresses), sometimes are therapeutic, and sometimes delay, alleviate or halt the progression of breast cancer. Any known preventative or therapeutic treatment for alleviating or preventing the occurrence of breast cancer is prescribed and/or administered. For example, certain preventative treatments often are prescribed to subjects having a predisposition to breast cancer and where the subject is not diagnosed with breast cancer or is diagnosed as having symptoms indicative of early stage breast cancer (e.g., stage I). For subjects not diagnosed as having breast cancer, any preventative treatments known in the art can be prescribed and administered, which include selective hormone receptor modulators (e.g., selective estrogen receptor modulators (SERMs) such as tamoxifen, reloxifene, and toremifene); compositions that prevent production of hormones (e.g., aramotase inhibitors that prevent the production of estrogen in the adrenal gland, such as exemestane, letrozole, anastrozol, groserelin, and megestrol); other hormonal treatments (e.g., goserelin acetate and fulvestrant); biologic response modifiers such as antibodies (e.g., trastuzumab (herceptin/HER2)); surgery (e.g., lumpectomy and mastectomy); drugs that delay or halt metastasis (e.g., pamidronate disodium); and alternative/complementary medicine (e.g., acupuncture, acupressure, moxibustion, qi gong, reiki, ayurveda, vitamins, minerals, and herbs (e.g., astragalus root, burdock root, garlic, green tea, and licorice root)).
The use of breast cancer treatments are well known in the art, and include surgery, chemotherapy and/or radiation therapy. Any of the treatments may be used in combination to treat or prevent breast cancer (e.g., surgery followed by radiation therapy or chemotherapy). Examples of chemotherapeutics are taxanes (e.g., docetaxel or paclitaxel), and examples of chemotherapy combinations used to treat breast cancer include: cyclophosphamide (Cytoxan), methotrexate (Amethopterin, Mexate, Folex), and fluorouracil (Fluorouracil, 5-Fu, Adrucil), which is referred to as CMF; cyclophosphamide, doxorubicin (Adriamycin), and fluorouracil, which is referred to as CAF; and doxorubicin (Adriamycin) and cyclophosphamide, which is referred to as AC.
As breast cancer preventative and treatment information can be specifically targeted to subjects in need thereof (e.g., those at risk of developing breast cancer or those that have early signs of breast cancer), provided herein is a method for preventing or reducing the risk of developing breast cancer in a subject, which comprises: (a) detecting the presence or absence of a polymorphic variation associated with breast cancer at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) identifying a subject with a predisposition to breast cancer, whereby the presence of the polymorphic variation is indicative of a predisposition to breast cancer in the subject; and (c) if such a predisposition is identified, providing the subject with information about methods or products to prevent or reduce breast cancer or to delay the onset of breast cancer. Also provided is a method of targeting information or advertising to a subpopulation of a human population based on the subpopulation being genetically predisposed to a disease or condition, which comprises: (a) detecting the presence or absence of a polymorphic variation associated with breast cancer at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) identifying the subpopulation of subjects in which the polymorphic variation is associated with breast cancer; and (c) providing information only to the subpopulation of subjects about a particular product which may be obtained and consumed or applied by the subject to help prevent or delay onset of the disease or condition.
Pharmacogenomics methods also may be used to analyze and predict a response to a breast cancer treatment or a drug. For example, if pharmacogenomics analysis indicates a likelihood that an individual will respond positively to a breast cancer treatment with a particular drug, the drug may be administered to the individual. Conversely, if the analysis indicates that an individual is likely to respond negatively to treatment with a particular drug, an alternative course of treatment may be prescribed. A negative response may be defined as either the absence of an efficacious response or the presence of toxic side effects. The response to a therapeutic treatment can be predicted in a background study in which subjects in any of the following populations are genotyped: a population that responds favorably to a treatment regimen, a population that does not respond significantly to a treatment regimen, and a population that responds adversely to a treatment regiment (e.g., exhibits one or more side effects). These populations are provided as examples and other populations and subpopulations may be analyzed. Based upon the results of these analyses, a subject is genotyped to predict whether he or she will respond favorably to a treatment regimen, not respond significantly to a treatment regimen, or respond adversely to a treatment regimen.
The methods described herein also are applicable to clinical drug trials. One or more polymorphic variants indicative of response to an agent for treating breast cancer or to side effects to an agent for treating breast cancer may be identified using the methods described herein. Thereafter, potential participants in clinical trials of such an agent may be screened to identify those individuals most likely to respond favorably to the drug and exclude those likely to experience side effects. In that way, the effectiveness of drug treatment may be measured in individuals who respond positively to the drug, without lowering the measurement as a result of the inclusion of individuals who are unlikely to respond positively in the study and without risking undesirable safety problems. In certain embodiments, the agent for treating breast cancer described herein targets ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 or a target in the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 pathway.
Thus, another embodiment is a method of selecting an individual for inclusion in a clinical trial of a treatment or drug comprising the steps of: (a) obtaining a nucleic acid sample from an individual; (b) determining the identity of a polymorphic variation which is associated with a positive response to the treatment or the drug, or at least one polymorphic variation which is associated with a negative response to the treatment or the drug in the nucleic acid sample, and (c) including the individual in the clinical trial if the nucleic acid sample contains said polymorphic variation associated with a positive response to the treatment or the drug or if the nucleic acid sample lacks said polymorphic variation associated with a negative response to the treatment or the drug. In addition, the methods for selecting an individual for inclusion in a clinical trial of a treatment or drug encompass methods with any further limitation described in this disclosure, or those following, specified alone or in any combination. The polymorphic variation may be in a sequence selected individually or in any combination from the group consisting of (i) a polynucleotide sequence set forth in SEQ ID NO: 1-7; (ii) a polynucleotide sequence that is 90% or more identical to a nucleotide sequence set forth in SEQ ID NO: 1-7; (iii) a polynucleotide sequence that encodes a polypeptide having an amino acid sequence identical to or 90% or more identical to an amino acid sequence encoded by a nucleotide sequence set forth in SEQ ID NO: 1-7; and (iv) a fragment of a polynucleotide sequence of (i), (ii), or (iii) comprising the polymorphic site. The including step (c) optionally comprises administering the drug or the treatment to the individual if the nucleic acid sample contains the polymorphic variation associated with a positive response to the treatment or the drug and the nucleic acid sample lacks said biallelic marker associated with a negative response to the treatment or the drug.
Also provided herein is a method of partnering between a diagnostic/prognostic testing provider and a provider of a consumable product, which comprises: (a) the diagnostic/prognostic testing provider detects the presence or absence of a polymorphic variation associated with breast cancer at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) the diagnostic/prognostic testing provider identifies the subpopulation of subjects in which the polymorphic variation is associated with breast cancer; (c) the diagnostic/prognostic testing provider forwards information to the subpopulation of subjects about a particular product which may be obtained and consumed or applied by the subject to help prevent or delay onset of the disease or condition; and (d) the provider of a consumable product forwards to the diagnostic test provider a fee every time the diagnostic/prognostic test provider forwards information to the subject as set forth in step (c) above.
Compositions Comprising Breast Cancer-Directed Molecules
Featured herein is a composition comprising a breast cancer cell and one or more molecules specifically directed and targeted to a nucleic acid comprising a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence or a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. Such directed molecules include, but are not limited to, a compound that binds to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid or a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide; a RNA1 or siRNA molecule having a strand complementary to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence; an antisense nucleic acid complementary to an RNA encoded by a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 DNA sequence; a ribozyme that hybridizes to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence; a nucleic acid aptamer that specifically binds a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide; and an antibody that specifically binds to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or binds to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid. In certain embodiments, the antibody specifically binds to an epitope that comprises a leucine at amino acid position 359 in SEQ ID NO: 23, a leucine at amino acid position 378 in SEQ ID NO: 23, an alanine at amino acid position 857 in SEQ ID NO: 23, an alanine at position 902 in SEQ ID NO: 23 a proline at amino acid position 352 in SEQ ID NO: 20 or an alanine at amino acid position 348 in SEQ ID NO: 20. In specific embodiments, the breast cancer directed molecule interacts with a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid or polypeptide variant associated with breast cancer. In other embodiments, the breast cancer directed molecule interacts with a polypeptide involved in the ICAM, MAPK10, KIAA 0861, NUMA1, GALE, DPF3 or LOC145197 signal pathway, or a nucleic acid encoding such a polypeptide. Polypeptides involved in the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 signal pathway are discussed herein.
Compositions sometimes include an adjuvant known to stimulate an immune response, and in certain embodiments, an adjuvant that stimulates a T-cell lymphocyte response. Adjuvants are known, including but not limited to an aluminum adjuvant (e.g., aluminum hydroxide); a cytokine adjuvant or adjuvant that stimulates a cytokine response (e.g., interleukin (IL)-12 and/or gamma-interferon cytokines); a Freund-type mineral oil adjuvant emulsion (e.g., Freund's complete or incomplete adjuvant); a synthetic lipoid compound; a copolymer adjuvant (e.g., TitreMax); a saponin; Quil A; a liposome; an oil-in-water emulsion (e.g., an emulsion stabilized by Tween 80 and pluronic polyoxyethlene/polyoxypropylene block copolymer (Syntex Adjuvant Formulation); TitreMax; detoxified endotoxin (MPL) and mycobacterial cell wall components (TDW, CWS) in 2% squalene (Ribi Adjuvant System)); a muramyl dipeptide; an immune-stimulating complex (ISCOM, e.g., an Ag-modified saponin/cholesterol micelle that forms stable cage-like structure); an aqueous phase adjuvant that does not have a depot effect (e.g., Gerbu adjuvant); a carbohydrate polymer (e.g., AdjuPrime); L-tyrosine; a manide-oleate compound (e.g., Montanide); an ethylene-vinyl acetate copolymer (e.g., Elvax 40W1,2); or lipid A, for example. Such compositions are useful for generating an immune response against a breast cancer directed molecule (e.g., an HLA-binding subsequence within a polypeptide encoded by a nucleotide sequence in SEQ ID NO: 1). In such methods, a peptide having an amino acid subsequence of a polypeptide encoded by a nucleotide sequence in SEQ ID NO: 1-7 is delivered to a subject, where the subsequence binds to an HLA molecule and induces a CTL lymphocyte response. The peptide sometimes is delivered to the subject as an isolated peptide or as a minigene in a plasmid that encodes the peptide. Methods for identifying HLA-binding subsequences in such polypeptides are known (see e.g., publication WO02/20616 and PCT application U.S.98/01373 for methods of identifying such sequences).
The breast cancer cell may be in a group of breast cancer cells and/or other types of cells cultured in vitro or in a tissue having breast cancer cells (e.g., a melanocytic lesion) maintained in vitro or present in an animal in vivo (e.g., a rat, mouse, ape or human). In certain embodiments, a composition comprises a component from a breast cancer cell or from a subject having a breast cancer cell instead of the breast cancer cell or in addition to the breast cancer cell, where the component sometimes is a nucleic acid molecule (e.g., genomic DNA), a protein mixture or isolated protein, for example. The aforementioned compositions have utility in diagnostic, prognostic and pharmacogenomic methods described previously and in breast cancer therapeutics described hereafter. Certain breast cancer molecules are described in greater detail below.
Compounds
Compounds can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; peptoid libraries (libraries of molecules having the functionalities of peptides, but with a novel, non-peptide backbone which are resistant to enzymatic degradation but which nevertheless remain bioactive (see, e.g., Zuckermann et al., J. Med. Chem. 37: 2678-85 (1994)); spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; “one-bead one-compound” library methods; and synthetic library methods using affinity chromatography selection. Biological library and peptoid library approaches are typically limited to peptide libraries, while the other approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam, Anticancer Drug Des. 12: 145, (1997)). Examples of methods for synthesizing molecular libraries are described, for example, in DeWitt et al., Proc. Natl. Acad. Sci. U.S.A. 90: 6909 (1993); Erb et al., Proc. Natl. Acad. Sci. USA 91: 11422 (1994); Zuckermann et al., J. Med. Chem. 37: 2678 (1994); Cho et al., Science 261: 1303 (1993); Carrell et al., Angew. Chem. Int. Ed. Engl. 33: 2059 (1994); Carell et al., Angew. Chem. Int. Ed. Engl. 33: 2061 (1994); and in Gallop et al., J. Med. Chem. 37: 1233 (1994).
Libraries of compounds may be presented in solution (e.g., Houghten, Biotechniques 13: 412-421 (1992)), or on beads (Lam, Nature 354: 82-84 (1991)), chips (Fodor, Nature 364: 555-556 (1993)), bacteria or spores (Ladner, U.S. Pat. No. 5,223,409), plasmids (Cull et al., Proc. Natl. Acad. Sci. USA 89: 1865-1869 (1992)) or on phage (Scott and Smith, Science 249: 386-390 (1990); Devlin, Science 249: 404-406 (1990); Cwirla et al., Proc. Natl. Acad. Sci. 87: 6378-6382 (1990); Felici, J. Mol. Biol. 222: 301-310 (1991); Ladner supra.).
A compound sometimes alters expression and sometimes alters activity of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide and may be a small molecule. Small molecules include, but are not limited to, peptides, peptidomimetics (e.g., peptoids), amino acids, amino acid analogs, polynucleotides, polynucleotide analogs, nucleotides, nucleotide analogs, organic or inorganic compounds (i.e., including heteroorganic and organometallic compounds) having a molecular weight less than about 10,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 5,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 1,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 500 grams per mole, and salts, esters, and other pharmaceutically acceptable forms of such compounds.
Antisense Nucleic Acid Molecules, Ribozymes. RNAi, siRNA and Modified Nucleic Acid Molecules
An “antisense” nucleic acid refers to a nucleotide sequence complementary to a “sense” nucleic acid encoding a polypeptide, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. The antisense nucleic acid can be complementary to an entire coding strand in SEQ ID NO: 1-17, or to a portion thereof or a substantially identical sequence thereof. In another embodiment, the antisense nucleic acid molecule is antisense to a “noncoding region” of the coding strand of a nucleotide sequence in SEQ ID NO: 1-17 (e.g., 5′ and 3′ untranslated regions).
An antisense nucleic acid can be designed such that it is complementary to the entire coding region of an mRNA encoded by a nucleotide sequence in SEQ ID NO: 1-7 (e.g., SEQ ID NO: 8-14), and often the antisense nucleic acid is an oligonucleotide antisense to only a portion of a coding or noncoding region of the mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of the mRNA, e.g., between the −10 and +10 regions of the target gene nucleotide sequence of interest. An antisense oligonucleotide can be, for example, about 7, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, or more nucleotides in length. The antisense nucleic acids, which include the ribozymes described hereafter, can be designed to target a nucleotide sequence in SEQ ID NO: 1-17, often a variant associated with breast cancer, or a substantially identical sequence thereof. Among the variants, minor alleles and major alleles can be targeted, and those associated with a higher risk of breast cancer are often designed, tested, and administered to subjects.
An antisense nucleic acid can be constructed using chemical synthesis and enzymatic ligation reactions using standard procedures. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. Antisense nucleic acid also can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).
When utilized as therapeutics, antisense nucleic acids typically are administered to a subject (e.g., by direct injection at a tissue site) or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a polypeptide and thereby inhibit expression of the polypeptide, for example, by inhibiting transcription and/or translation. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then are administered systemically. For systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface, for example, by linking antisense nucleic acid molecules to peptides or antibodies which bind to cell surface receptors or antigens. Antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. Sufficient intracellular concentrations of antisense molecules are achieved by incorporating a strong promoter, such as a pol II or pol III promoter, in the vector construct.
Antisense nucleic acid molecules sometimes are alpha-anomeric nucleic acid molecules. An alpha-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual beta-units, the strands run parallel to each other (Gaultier et al., Nucleic Acids. Res. 15: 6625-6641 (1987)). Antisense nucleic acid molecules can also comprise a 2′-o-methylribonucleotide (Inoue et al., Nucleic Acids Res. 15: 6131-6148 (1987)) or a chimeric RNA-DNA analogue (Inoue et al., FEBS Lett. 215: 327-330 (1987)). Antisense nucleic acids sometimes are composed of DNA or PNA or any other nucleic acid derivatives described previously.
In another embodiment, an antisense nucleic acid is a ribozyme. A ribozyme having specificity for a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence can include one or more sequences complementary to such a nucleotide sequence, and a sequence having a known catalytic region responsible for mRNA cleavage (see e.g., U.S. Pat. No. 5,093,246 or Haselhoff and Gerlach, Nature 334: 585-591(1988)). For example, a derivative of a Tetrahymena L-19 IVS RNA is sometimes utilized in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in a mRNA (see e.g., Cech et al., U.S. Pat. No. 4,987,071; and Cech et al. U.S. Pat. No. 5,116,742). Also, target mRNA sequences can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules (see e.g., Bartel & Szostak, Science 261: 1411-1418(1993)).
Breast cancer directed molecules include in certain embodiments nucleic acids that can form triple helix structures with a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence or a substantially identical sequence thereof, especially one that includes a regulatory region that controls expression of a polypeptide. Gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence or a substantially identical sequence (e.g., promoter and/or enhancers) to form triple helical structures that prevent transcription of a gene in target cells (see e.g., Helene, Anticancer Drug Des. 6(6): 569-84 (1991); Helene et al., Ann. N.Y. Acad. Sci. 660: 27-36 (1992); and Maher, Bioassays 14(12): 807-15 (1992). Potential sequences that can be targeted for triple helix formation can be increased by creating a so-called “switchback” nucleic acid molecule. Switchback molecules are synthesized in an alternating 5′-3′,3′-5′ manner, such that they base pair with first one strand of a duplex and then the other, eliminating the necessity for a sizeable stretch of either purines or pyrimidines to be present on one strand of a duplex.
Breast cancer directed molecules include RNAi and siRNA nucleic acids. Gene expression may be inhibited by the introduction of double-stranded RNA (dsRNA), which induces potent and specific gene silencing, a phenomenon called RNA interference or RNAi. See, e.g., Fire et al., U.S. Pat. No. 6,506,559; Tuschl et al. PCT International Publication No. WO 01/75164; Kay et al. PCT International Publication No. WO 03/010180A1; or Bosher J M, Labouesse, Nat Cell Biol 2000 February; 2(2): E31-6. This process has been improved by decreasing the size of the double-stranded RNA to 20-24 base pairs (to create small-interfering RNAs or siRNAs) that “switched off” genes in mammalian cells without initiating an acute phase response, i.e., a host defense mechanism that often results in cell death (see, e.g., Caplen et al. Proc Natl Acad Sci USA. 2001 Aug. 14; 98(17): 9742-7 and Elbashir et al. Methods 2002 February; 26(2): 199-213). There is increasing evidence of post-transcriptional gene silencing by RNA interference (RNAi) for inhibiting targeted expression in mammalian cells at the mRNA level, in human cells. There is additional evidence of effective methods for inhibiting the proliferation and migration of tumor cells in human patients, and for inhibiting metastatic cancer development (see, e.g., U.S. Patent Application No. U.S. 2001000993183; Caplen et al. Proc Natl Acad Sci USA; and Abderrahmani et al. Mol Cell Biol 2001 November 21(21): 7256-67).
An “siRNA” or “RNAi” refers to a nucleic acid that forms a double stranded RNA and has the ability to reduce or inhibit expression of a gene or target gene when the siRNA is delivered to or expressed in the same cell as the gene or target gene. “siRNA” refers to short double-stranded RNA formed by the complementary strands. Complementary portions of the siRNA that hybridize to form the double stranded molecule often have substantial or complete identity to the target molecule sequence. In one embodiment, an siRNA refers to a nucleic acid that has substantial or complete identity to a target gene and forms a double stranded siRNA.
When designing the siRNA molecules, the targeted region often is selected from a given DNA sequence beginning 50 to 100 nucleotides downstream of the start codon. See, e.g., Elbashir et al.,. Methods 26: 199-213 (2002). Initially, 5′ or 3′ UTRs and regions nearby the start codon were avoided assuming that UTR-binding proteins and/or translation initiation complexes may interfere with binding of the siRNP or RISC endonuclease complex. Sometimes regions of the target 23 nucleotides in length conforming to the sequence motif AA(N19)TT (N, an nucleotide), and regions with approximately 30% to 70% G/C-content (often about 50% G/C-content) often are selected. If no suitable sequences are found, the search often is extended using the motif NA(N21). The sequence of the sense siRNA sometimes corresponds to (N 9) TT or N21 (position 3 to 23 of the 23-nt motif), respectively. In the latter case, the 3′ end of the sense siRNA often is converted to TT. The rationale for this sequence conversion is to generate a symmetric duplex with respect to the sequence composition of the sense and antisense 3′ overhangs. The antisense siRNA is synthesized as the complement to position 1 to 21 of the 23-nt motif. Because position 1 of the 23-nt motif is not recognized sequence-specifically by the antisense siRNA, the 3′-most nucleotide residue of the antisense siRNA can be chosen deliberately. However, the penultimate nucleotide of the antisense siRNA (complementary to position 2 of the 23-nt motif) often is complementary to the targeted sequence. For simplifying chemical synthesis, TT often is utilized. siRNAs corresponding to the target motif NAR(N17)YNN, where R is purine (A,G) and Y is pyrimidine (C,U), often are selected. Respective 21 nucleotide sense and antisense siRNAs often begin with a purine nucleotide and can also be expressed from pol III expression vectors without a change in targeting site. Expression of RNAs from pol III promoters often is efficient when the first transcribed nucleotide is a purine.
The sequence of the siRNA can correspond to the full length target gene, or a subsequence thereof. Often, the siRNA is about 15 to about 50 nucleotides in length (e.g., each complementary sequence of the double stranded siRNA is 15-50 nucleotides in length, and the double stranded siRNA is about 15-50 base pairs in length, sometimes about 20-30 nucleotides in length or about 20-25 nucleotides in length, e.g., 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 nucleotides in length. The siRNA sometimes is about 21 nucleotides in length. Methods of using siRNA are well known in the art, and specific siRNA molecules may be purchased from a number of companies including Dharmacon Research, Inc.
Antisense, ribozyme, RNAi and siRNA nucleic acids can be altered to form modified nucleic acid molecules. The nucleic acids can be altered at base moieties, sugar moieties or phosphate backbone moieties to improve stability, hybridization, or solubility of the molecule. For example, the deoxyribose phosphate backbone of nucleic acid molecules can be modified to generate peptide nucleic acids (see Hyrup et al., Bioorganic & Medicinal Chemistry 4 (1): 5-23 (1996)). As used herein, the terms “peptide nucleic acid” or “PNA” refers to a nucleic acid mimic such as a DNA mimic, in which the deoxyribose phosphate backbone is replaced by a pseudopeptide backbone and only the four natural nucleobases are retained. The neutral backbone of a PNA can allow for specific hybridization to DNA and RNA under conditions of low ionic strength. Synthesis of PNA oligomers can be performed using standard solid phase peptide synthesis protocols as described, for example, in Hyrup et al., (1996) supra and Perry-O'Keefe et al., Proc. Natl. Acad. Sci. 93: 14670-675 (1996).
PNA nucleic acids can be used in prognostic, diagnostic, and therapeutic applications. For example, PNAs can be used as antisense or antigene agents for sequence-specific modulation of gene expression by, for example, inducing transcription or translation arrest or inhibiting replication. PNA nucleic acid molecules can also be used in the analysis of single base pair mutations in a gene, (e.g., by PNA-directed PCR clamping); as “artificial restriction enzymes” when used in combination with other enzymes, (e.g., S1 nucleases (Hyrup (1996) supra)); or as probes or primers for DNA sequencing or hybridization (Hyrup et al., (1996) supra; Perry-O'Keefe supra).
In other embodiments, oligonucleotides may include other appended groups such as peptides (e.g., for targeting host cell receptors in vivo), or agents facilitating transport across cell membranes (see e.g., Letsinger et al., Proc. Natl. Acad. Sci. USA 86: 6553-6556 (1989); Lemaitre et al., Proc. Natl. Acad. Sci. USA 84: 648-652 (1987); PCT Publication No. WO88/09810) or the blood-brain barrier (see, e.g., PCT Publication No. WO89/10134). In addition, oligonucleotides can be modified with hybridization-triggered cleavage agents (See, e.g., Krol et al., Bio-Techniques 6: 958-976 (1988)) or intercalating agents. (See, e.g., Zon, Pharm. Res. 5: 539-549 (1988)). To this end, the oligonucleotide may be conjugated to another molecule, (e.g., a peptide, hybridization triggered cross-linking agent, transport agent, or hybridization-triggered cleavage agent).
Also included herein are molecular beacon oligonucleotide primer and probe molecules having one or more regions complementary to a nucleotide sequence of SEQ ID NO: 1-17 or a substantially identical sequence thereof, two complementary regions one having a fluorophore and one a quencher such that the molecular beacon is useful for quantifying the presence of the nucleic acid in a sample. Molecular beacon nucleic acids are described, for example, in Lizardi et al., U.S. Pat. No. 5,854,033; Nazarenko et al., U.S. Pat. No. 5,866,336, and Livak et al., U.S. Pat. No. 5,876,930.
Antibodies
The term “antibody” as used herein refers to an immunoglobulin molecule or immunologically active portion thereof, i.e., an antigen-binding portion. Examples of immunologically active portions of immunoglobulin molecules include F(ab) and F(ab′)2 fragments which can be generated by treating the antibody with an enzyme such as pepsin. An antibody sometimes is a polyclonal, monoclonal, recombinant (e.g, a chimeric or humanized), fully human, non-human (e.g., murine), or a single chain antibody. For example, antibodies that specifically bind to ICAM1 are disclosed in U.S. Pat. Nos. 5,475,091 and 5,773,293. An antibody may have effector function and can fix complement, and is sometimes coupled to a toxin or imaging agent.
A full-length polypeptide or antigenic peptide fragment encoded by a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleotide sequence can be used as an immunogen or can be used to identify antibodies made with other immunogens, e.g., cells, membrane preparations, and the like. An antigenic peptide often includes at least 8 amino acid residues of the amino acid sequences encoded by a nucleotide sequence of SEQ ID NO: 1-17, or substantially identical sequence thereof, and encompasses an epitope. Antigenic peptides sometimes include 10 or more amino acids, 15 or more amino acids, 20 or more amino acids, or 30 or more amino acids. Hydrophilic and hydrophobic fragments of polypeptides sometimes are used as immunogens.
Epitopes encompassed by the antigenic peptide are regions located on the surface of the polypeptide (e.g., hydrophilic regions) as well as regions with high antigenicity. For example, an Emini surface probability analysis of the human polypeptide sequence can be used to indicate the regions that have a particularly high probability of being localized to the surface of the polypeptide and are thus likely to constitute surface residues useful for targeting antibody production. The antibody may bind an epitope on any domain or region on polypeptides described herein.
Also, chimeric, humanized, and completely human antibodies are useful for applications which include repeated administration to subjects. Chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, can be made using standard recombinant DNA techniques. Such chimeric and humanized monoclonal antibodies can be produced by recombinant DNA techniques known in the art, for example using methods described in Robinson et al. International Application No. PCT/US86/02269; Akira, et al. European Patent Application 184,187; Taniguchi, M., European Patent Application 171,496; Morrison et al. European Patent Application 173,494; Neuberger et al. PCT International Publication No. WO 86/01533; Cabilly et al. U.S. Pat. No. 4,816,567; Cabilly et al. European Patent Application 125,023; Better et al., Science 240: 1041-1043 (1988); Liu et al., Proc. Natl. Acad. Sci. USA 84: 3439-3443 (1987); Liu et al., J. Immunol. 139: 3521-3526 (1987); Sun et al., Proc. Natl. Acad. Sci. USA 84: 214-218 (1987); Nishimura et al., Canc. Res. 47: 999-1005 (1987); Wood et al., Nature 314: 446-449 (1985); and Shaw et al., J. Natl. Cancer Inst. 80: 1553-1559 (1988); Morrison, S. L., Science 229: 1202-1207 (1985); Oi et al., BioTechniques 4: 214 (1986); Winter U.S. Pat. No. 5,225,539; Jones et al., Nature 321: 552-525 (1986); Verhoeyan et al., Science 239: 1534; and Beidler et al., J. Immunol. 141: 4053-4060 (1988).
Completely human antibodies are particularly desirable for therapeutic treatment of human patients. Such antibodies can be produced using transgenic mice that are incapable of expressing endogenous immunoglobulin heavy and light chains genes, but which can express human heavy and light chain genes. See, for example, Lonberg and Huszar, Int. Rev. Immunol. 13: 65-93 (1995); and U.S. Pat. Nos. 5,625,126; 5,633,425; 5,569,825; 5,661,016; and 5,545,806. In addition, companies such as Abgenix, Inc. (Fremont, Calif.) and Medarex, Inc. (Princeton, N.J.), can be engaged to provide human antibodies directed against a selected antigen using technology similar to that described above. Completely human antibodies that recognize a selected epitope also can be generated using a technique referred to as “guided selection.” In this approach a selected non-human monoclonal antibody (e.g., a murine antibody) is used to guide the selection of a completely human antibody recognizing the same epitope. This technology is described for example by Jespers et al., Bio/Technology 12: 899-903 (1994).
Antibody can be a single chain antibody. A single chain antibody (scFV) can be engineered (see, e.g., Colcher et al., Ann. N Y Acad. Sci. 880: 263-80 (1999); and Reiter, Clin. Cancer Res. 2: 245-52 (1996)). Single chain antibodies can be dimerized or multimerized to generate multivalent antibodies having specificities for different epitopes of the same target polypeptide.
Antibodies also may be selected or modified so that they exhibit reduced or no ability to bind an Fc receptor. For example, an antibody may be an isotype or subtype, fragment or other mutant, which does not support binding to an Fc receptor (e.g., it has a mutagenized or deleted Fc receptor binding region).
Also, an antibody (or fragment thereof) may be conjugated to a therapeutic moiety such as a cytotoxin, a therapeutic agent or a radioactive metal ion. A cytotoxin or cytotoxic agent includes any agent that is detrimental to cells. Examples include taxol, cytochalasin B, gramicidin D, ethidium bromide, emetine, mitomycin, etoposide, tenoposide, vincristine, vinblastine, colchicin, doxorubicin, daunorubicin, dihydroxy anthracin dione, mitoxantrone, mithramycin, actinomycin D, 1 dehydrotestosterone, glucocorticoids, procaine, tetracaine, lidocaine, propranolol, and puromycin and analogs or homologs thereof. Therapeutic agents include, but are not limited to, antimetabolites (e.g., methotrexate, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-fluorouracil decarbazine), alkylating agents (e.g., mechlorethamine, thiotepa chlorambucil, melphalan, carmustine (BCNU) and lomustine (CCNU), cyclophosphamide, busulfan, dibromomannitol, streptozotocin, mitomycin C, and cis-dichlorodiamine platinum (II) (DDP) cisplatin), anthracyclines (e.g., daunorubicin (formerly daunomycin) and doxorubicin), antibiotics (e.g., dactinomycin (formerly actinomycin), bleomycin, mithramycin, and anthramycin (AMC)), and anti-mitotic agents (e.g., vincristine and vinblastine).
Antibody conjugates can be used for modifying a given biological response. For example, the drug moiety may be a protein or polypeptide possessing a desired biological activity. Such proteins may include, for example, a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin; a polypeptide such as tumor necrosis factor, ?-interferon, a-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator; or, biological response modifiers such as, for example, lymphokines, interleukin-1 (“IL-1”), interleukin-2 (“IL-2”), interleukin-6 (“1L-6”), granulocyte macrophage colony stimulating factor (“GM-CSF”), granulocyte colony stimulating factor (“G-CSF”), or other growth factors. Also, an antibody can be conjugated to a second antibody to form an antibody heteroconjugate as described by Segal in U.S. Pat. No. 4,676,980, for example.
An antibody (e.g., monoclonal antibody) can be used to isolate target polypeptides by standard techniques, such as affinity chromatography or immunoprecipitation. Moreover, an antibody can be used to detect a target polypeptide (e.g., in a cellular lysate or cell supernatant) in order to evaluate the abundance and pattern of expression of the polypeptide. Antibodies can be used diagnostically to monitor polypeptide levels in tissue as part of a clinical testing procedure, e.g., to determine the efficacy of a given treatment regimen. Detection can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance (i.e., antibody labeling). Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include 125I, 131I, 35S or 3H. Also, an antibody can be utilized as a test molecule for determining whether it can treat breast cancer, and as a therapeutic for administration to a subject for treating breast cancer.
An antibody can be made by immunizing with a purified antigen, or a fragment thereof, e.g., a fragment described herein, a membrane associated antigen, tissues, e.g., crude tissue preparations, whole cells, preferably living cells, lysed cells, or cell fractions.
Included herein are antibodies which bind only a native polypeptide, only denatured or otherwise non-native polypeptide, or which bind both, as well as those having linear or conformational epitopes. Conformational epitopes sometimes can be identified by selecting antibodies that bind to native but not denatured polypeptide. Also featured are antibodies that specifically bind to a polypeptide variant associated with breast cancer.
Screening Assays
Featured herein are methods for identifying a candidate therapeutic for treating breast cancer. The methods comprise contacting a test molecule with a target molecule in a system. A “target molecule” as used herein refers to a nucleic acid of SEQ ID NO: 1-17, a substantially identical nucleic acid thereof, or a fragment thereof, and an encoded polypeptide of the foregoing. The method also comprises determining the presence or absence of an interaction between the test molecule and the target molecule, where the presence of an interaction between the test molecule and the nucleic acid or polypeptide identifies the test molecule as a candidate breast cancer therapeutic. The interaction between the test molecule and the target molecule may be quantified.
Test molecules and candidate therapeutics include, but are not limited to, compounds, antisense nucleic acids, siRNA molecules, ribozymes, polypeptides or proteins encoded by a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acids, or a substantially identical sequence or fragment thereof, and immunotherapeutics (e.g., antibodies and HLA-presented polypeptide fragments). A test molecule or candidate therapeutic may act as a modulator of target molecule concentration or target molecule function in a system. A “modulator” may agonize (i.e., up-regulates) or antagonize (i.e., down-regulates) a target molecule concentration partially or completely in a system by affecting such cellular functions as DNA replication and/or DNA processing (e.g., DNA methylation or DNA repair), RNA transcription and/or RNA processing (e.g., removal of intronic sequences and/or translocation of spliced mRNA from the nucleus), polypeptide production (e.g., translation of the polypeptide from mRNA), and/or polypeptide post-translational modification (e.g., glycosylation, phosphorylation, and proteolysis of pro-polypeptides). A modulator may also agonize or antagonize a biological function of a target molecule partially or completely, where the function may include adopting a certain structural conformation, interacting with one or more binding partners, ligand binding, catalysis (e.g., phosphorylation, dephosphorylation, hydrolysis, methylation, and isomerization), and an effect upon a cellular event (e.g., effecting progression of breast cancer).
As used herein, the term “system” refers to a cell free in vitro environment and a cell-based environment such as a collection of cells, a tissue, an organ, or an organism. A system is “contacted” with a test molecule in a variety of manners, including adding molecules in solution and allowing them to interact with one another by diffusion, cell injection, and any administration routes in an animal. As used herein, the term “interaction” refers to an effect of a test molecule on test molecule, where the effect sometimes is binding between the test molecule and the target molecule, and sometimes is an observable change in cells, tissue, or organism.
There are many standard methods for detecting the presence or absence of an interaction between a test molecule and a target molecule. For example, titrametric, acidimetric, radiometric, NMR, monolayer, polarographic, spectrophotometric, fluorescent, and ESR assays probative of a target molecule interaction may be utilized.
In general, an interaction can be determined by labeling the test molecule and/or the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule, where the label is covalently or non-covalently attached to the test molecule or ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule. The label is sometimes a radioactive molecule such as 125I, 131I, 35S or 3H, which can be detected by direct counting of radioemission or by scintillation counting. Also, enzymatic labels such as horseradish peroxidase, alkaline phosphatase, or luciferase may be utilized where the enzymatic label can be detected by determining conversion of an appropriate substrate to product. Also, presence or absence of an interaction can be determined without labeling. For example, a microphysiometer (e.g., Cytosensor) is an analytical instrument that measures the rate at which a cell acidifies its environment using a light-addressable potentiometric sensor (LAPS). Changes in this acidification rate can be used as an indication of an interaction between a test molecule and ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 (McConnell, H. M. et al., Science 257: 1906-1912 (1992)).
In cell-based systems, cells typically include a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid or polypeptide or variants thereof and are often of mammalian origin, although the cell can be of any origin. Whole cells, cell homogenates, and cell fractions (e.g., cell membrane fractions) can be subjected to analysis. Where interactions between a test molecule with a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or variant thereof are monitored, soluble and/or membrane bound forms of the polypeptide or variant may be utilized. Where membrane-bound forms of the polypeptide are used, it may be desirable to utilize a solubilizing agent. Examples of such solubilizing agents include non-ionic detergents such as n-octylglucoside, n-dodecylglucoside, n-dodecylmaltoside, octanoyl-N-methylglucamide, decanoyl-N-methylglucamide, Triton® X-100, Triton® X-114, Thesit®, Isotridecypoly(ethylene glycol ether)n, 3-[(3-cholamidopropyl)dimethylamminio]-1-propane sulfonate (CHAPS), 3-[(3-cholamidopropyl)dimethylamminio]-2-hydroxy-1-propane sulfonate (CHAPSO), or N-dodecyl-N,N-dimethyl-3-ammonio-1-propane sulfonate.
An interaction between two molecules also can be detected by monitoring fluorescence energy transfer (FET) (see, for example, Lakowicz et al., U.S. Pat. No. 5,631,169; Stavrianopoulos et al. U.S. Pat. No. 4,868,103). A fluorophore label on a first, “donor” molecule is selected such that its emitted fluorescent energy will be absorbed by a fluorescent label on a second, “acceptor” molecule, which in turn is able to fluoresce due to the absorbed energy. Alternately, the “donor” polypeptide molecule may simply utilize the natural fluorescent energy of tryptophan residues. Labels are chosen that emit different wavelengths of light, such that the “acceptor” molecule label may be differentiated from that of the “donor”. Since the efficiency of energy transfer between the labels is related to the distance separating the molecules, the spatial relationship between the molecules can be assessed. In a situation in which binding occurs between the molecules, the fluorescent emission of the “acceptor” molecule label in the assay should be maximal. A FET binding event can be conveniently measured through standard fluorometric detection means well known in the art (e.g., using a fluorimeter).
In another embodiment, determining the presence or absence of an interaction between a test molecule and a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule can be effected by using real-time Biomolecular Interaction Analysis (BIA) (see, e.g., Sjolander & Urbaniczk, Anal. Chem. 63: 2338-2345 (1991) and Szabo et al., Curr. Opin. Struct. Biol. 5: 699-705 (1995)). “Surface plasmon resonance” or “BIA” detects biospecific interactions in real time, without labeling any of the interactants (e.g., BIAcore). Changes in the mass at the binding surface (indicative of a binding event) result in alterations of the refractive index of light near the surface (the optical phenomenon of surface plasmon resonance (SPR)), resulting in a detectable signal which can be used as an indication of real-time reactions between biological molecules.
In another embodiment, the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule or test molecules are anchored to a solid phase. The ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule/test molecule complexes anchored to the solid phase can be detected at the end of the reaction. The target ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule is often anchored to a solid surface, and the test molecule, which is not anchored, can be labeled, either directly or indirectly, with detectable labels discussed herein.
It may be desirable to immobilize a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule, an anti-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 antibody, or test molecules to facilitate separation of complexed from uncomplexed forms of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecules and test molecules, as well as to accommodate automation of the assay. Binding of a test molecule to a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule can be accomplished in any vessel suitable for containing the reactants. Examples of such vessels include microtiter plates, test tubes, and micro-centrifuge tubes. In one embodiment, a fusion polypeptide can be provided which adds a domain that allows a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule to be bound to a matrix. For example, glutathione-S-transferase/ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 fusion polypeptides or glutathione-S-transferase/target fusion polypeptides can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, Mo.) or glutathione derivitized microtiter plates, which are then combined with the test compound or the test compound and either the non-adsorbed target polypeptide or ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide, and the mixture incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads or microtiter plate wells are washed to remove any unbound components, the matrix immobilized in the case of beads, complex determined either directly or indirectly, for example, as described above. Alternatively, the complexes can be dissociated from the matrix, and the level of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 binding or activity determined using standard techniques.
Other techniques for immobilizing a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule on matrices include using biotin and streptavidin. For example, biotinylated ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or target molecules can be prepared from biotin-NHS(N-hydroxy-succinimide) using techniques known in the art (e.g., biotinylation kit, Pierce Chemicals, Rockford, Ill.), and immobilized in the wells of streptavidin-coated 96 well plates (Pierce Chemical).
In order to conduct the assay, the non-immobilized component is added to the coated surface containing the anchored component. After the reaction is complete, unreacted components are removed (e.g., by washing) under conditions such that any complexes formed will remain immobilized on the solid surface. The detection of complexes anchored on the solid surface can be accomplished in a number of ways. Where the previously non-immobilized component is pre-labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the previously non-immobilized component is not pre-labeled, an indirect label can be used to detect complexes anchored on the surface; e.g., using a labeled antibody specific for the immobilized component (the antibody, in turn, can be directly labeled or indirectly labeled with, e.g., a labeled anti-Ig antibody).
In one embodiment, this assay is performed utilizing antibodies reactive with ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or test molecules but which do not interfere with binding of the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide to its test molecule. Such antibodies can be derivitized to the wells of the plate, and unbound target or ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide trapped in the wells by antibody conjugation. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or target molecule, as well as enzyme-linked assays which rely on detecting an enzymatic activity associated with the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or test molecule.
Alternatively, cell free assays can be conducted in a liquid phase. In such an assay, the reaction products are separated from unreacted components, by any of a number of standard techniques, including but not limited to: differential centrifugation (see, for example, Rivas, G., and Minton, A. P., Trends Biochem Sci August; 18(8): 284-7 (1993)); chromatography (gel filtration chromatography, ion-exchange chromatography); electrophoresis (see, e.g., Ausubel et al., eds. Current Protocols in Molecular Biology, J. Wiley: New York (1999)); and immunoprecipitation (see, for example, Ausubel, F. et al., eds. Current Protocols in Molecular Biology, J. Wiley: New York (1999)). Such resins and chromatographic techniques are known to one skilled in the art (see, e.g., Heegaard, J. Mol. Recognit. Winter; 11(1-6): 141-8 (1998); Hage & Tweed, J. Chromatogr. B Biomed. Sci. Appl. October 10; 699 (1-2): 499-525 (1997)). Further, fluorescence energy transfer may also be conveniently utilized, as described herein, to detect binding without further purification of the complex from solution.
In another embodiment, modulators of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 expression are identified. For example, a cell or cell free mixture is contacted with a candidate compound and the expression of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 mRNA or polypeptide evaluated relative to the level of expression of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 mRNA or polypeptide in the absence of the candidate compound. When expression of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 mRNA or polypeptide is greater in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 mRNA or polypeptide expression. Alternatively, when expression of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 mRNA or polypeptide is less (statistically significantly less) in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 mRNA or polypeptide expression. The level of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 mRNA or polypeptide expression can be determined by methods described herein for detecting ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 mRNA or polypeptide.
In another embodiment, binding partners that interact with a ICAM, MAPK1, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule are detected. The ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecules can interact with one or more cellular or extracellular macromolecules, such as polypeptides, in vivo, and these molecules that interact with ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecules are referred to herein as “binding partners.” Molecules that disrupt such interactions can be useful in regulating the activity of the target gene product. Such molecules can include, but are not limited to molecules such as antibodies, peptides, and small molecules. Target genes/products for use in this embodiment often are the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 genes herein identified. In an alternative embodiment, provided is a method for determining the ability of the test compound to modulate the activity of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide through modulation of the activity of a downstream effector of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 target molecule. For example, the activity of the effector molecule on an appropriate target can be determined, or the binding of the effector to an appropriate target can be determined, as previously described.
To identify compounds that interfere with the interaction between the target gene product and its cellular or extracellular binding partner(s), e.g., a substrate, a reaction mixture containing the target gene product and the binding partner is prepared, under conditions and for a time sufficient, to allow the two products to form complex. In order to test an inhibitory agent, the reaction mixture is provided in the presence and absence of the test compound. The test compound can be initially included in the reaction mixture, or can be added at a time subsequent to the addition of the target gene and its cellular or extracellular binding partner. Control reaction mixtures are incubated without the test compound or with a placebo. The formation of any complexes between the target gene product and the cellular or extracellular binding partner is then detected. The formation of a complex in the control reaction, but not in the reaction mixture containing the test compound, indicates that the compound interferes with the interaction of the target gene product and the interactive binding partner. Additionally, complex formation within reaction mixtures containing the test compound and normal target gene product can also be compared to complex formation within reaction mixtures containing the test compound and mutant target gene product. This comparison can be important in those cases where it is desirable to identify compounds that disrupt interactions of mutant but not normal target gene products. Examples of ICAM1 inhibitors are Actimid and Bortezomib, and U.S. Pat. No. 6,436,403 describes a conjugate between ICAM1 and a virus for ICAM1 delivery. Examples of MAPK10 and JUNK modulators are beta arrestin (ARBB2), which is an agonist, CC-401 (Celgene), which is an inhibitor, and other modulators disclosed in WO0246184A1, WO02083667A2, WO02079197A1, WO0112621A1, WO04005283A1, WO0210137A2, WO0112609A1, WO03099221A2, WO02066450A2, WO03102151A2, U.S. 20020160397A1. Examples of MAPK1 screening methods are disclosed in U.S. Pat. No. 6,610,505.
These assays can be conducted in a heterogeneous or homogeneous format. Heterogeneous assays involve anchoring either the target gene product or the binding partner onto a solid phase, and detecting complexes anchored on the solid phase at the end of the reaction. In homogeneous assays, the entire reaction is carried out in a liquid phase. In either approach, the order of addition of reactants can be varied to obtain different information about the compounds being tested. For example, test compounds that interfere with the interaction between the target gene products and the binding partners, e.g., by competition, can be identified by conducting the reaction in the presence of the test substance. Alternatively, test compounds that disrupt preformed complexes, e.g., compounds with higher binding constants that displace one of the components from the complex, can be tested by adding the test compound to the reaction mixture after complexes have been formed. The various formats are briefly described below.
In a heterogeneous assay system, either the target gene product or the interactive cellular or extracellular binding partner, is anchored onto a solid surface (e.g., a microtiter plate), while the non-anchored species is labeled, either directly or indirectly. The anchored species can be immobilized by non-covalent or covalent attachments. Alternatively, an immobilized antibody specific for the species to be anchored can be used to anchor the species to the solid surface.
In order to conduct the assay, the partner of the immobilized species is exposed to the coated surface with or without the test compound. After the reaction is complete, unreacted components are removed (e.g., by washing) and any complexes formed will remain immobilized on the solid surface. Where the non-immobilized species is pre-labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the non-immobilized species is not pre-labeled, an indirect label can be used to detect complexes anchored on the surface; e.g., using a labeled antibody specific for the initially non-immobilized species (the antibody, in turn, can be directly labeled or indirectly labeled with, e.g., a labeled anti-Ig antibody). Depending upon the order of addition of reaction components, test compounds that inhibit complex formation or that disrupt preformed complexes can be detected.
Alternatively, the reaction can be conducted in a liquid phase in the presence or absence of the test compound, the reaction products separated from unreacted components, and complexes detected; e.g., using an immobilized antibody specific for one of the binding components to anchor any complexes formed in solution, and a labeled antibody specific for the other partner to detect anchored complexes. Again, depending upon the order of addition of reactants to the liquid phase, test compounds that inhibit complex or that disrupt preformed complexes can be identified.
In an alternate embodiment, a homogeneous assay can be used. For example, a preformed complex of the target gene product and the interactive cellular or extracellular binding partner product is prepared in that either the target gene products or their binding partners are labeled, but the signal generated by the label is quenched due to complex formation (see, e.g., U.S. Pat. No. 4,109,496 that utilizes this approach for immunoassays). The addition of a test substance that competes with and displaces one of the species from the preformed complex will result in the generation of a signal above background. In this way, test substances that disrupt target gene product-binding partner interaction can be identified.
Also, binding partners of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecules can be identified in a two-hybrid assay or three-hybrid assay (see, e.g., U.S. Pat. No. 5,283,317; Zervos et al., Cell 72: 223-232 (1993); Madura et al., J. Biol. Chem. 268: 12046-12054 (1993); Bartel et al., Biotechniques 14: 920-924 (1993); Iwabuchi et al., Oncogene 8: 1693-1696 (1993); and Brent WO94/10300), to identify other polypeptides, which bind to or interact with ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 (“ICAM, MAPK10, KIAA0861, NUAM1, GALE, DPF3 or LOC145197-binding polypeptides” or “ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197-bp”) and are involved in ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activity. Such ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197-bps can be activators or inhibitors of signals by the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptides or ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 targets as, for example, downstream elements of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197-mediated signaling pathway.
A two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains. Briefly, the assay utilizes two different DNA constructs. In one construct, the gene that codes for a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In the other construct, a DNA sequence, from a library of DNA sequences, that encodes an unidentified polypeptide (“prey” or “sample”) is fused to a gene that codes for the activation domain of the known transcription factor. (Alternatively the: ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide can be the fused to the activator domain.) If the “bait” and the “prey” polypeptides are able to interact, in vivo, forming a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g., LacZ) which is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene which encodes the polypeptide which interacts with the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide.
Candidate therapeutics for treating breast cancer are identified from a group of test molecules that interact with a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid or polypeptide. Test molecules are normally ranked according to the degree with which they interact or modulate (e.g., agonize or antagonize) DNA replication and/or processing, RNA transcription and/or processing, polypeptide production and/or processing, and/or function of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecules, for example, and then top ranking modulators are selected. In a preferred embodiment, the candidate therapeutic (i.e., test molecule) acts as a ICAM, MAPK10, KIAA0861, NUAM1, GALE, DPF3 or LOC145197 antagonist. Also, pharmacogenomic information described herein can determine the rank of a modulator. Candidate therapeutics typically are formulated for administration to a subject.
Therapeutic Treatments
Formulations or pharmaceutical compositions typically include in combination with a pharmaceutically acceptable carrier, a compound, an antisense nucleic acid, a ribozyme, an antibody, a binding partner that interacts with a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide, a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid, or a fragment thereof. The formulated molecule may be one that is identified by a screening method described above. As used herein, the term “pharmaceutically acceptable carrier” includes solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like, compatible with pharmaceutical administration. Supplementary active compounds can also be incorporated into the compositions.
A pharmaceutical composition is formulated to be compatible with its intended route of administration. Examples of routes of administration include parenteral, e.g., intravenous, intradermal, subcutaneous, oral (e.g., inhalation), transdermal (topical), transmucosal, and rectal administration. Solutions or suspensions used for parenteral, intradermal, or subcutaneous application can include the following components: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerin, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylenediaminetetraacetic acid; buffers such as acetates, citrates or phosphates and agents for the adjustment of tonicity such as sodium chloride or dextrose. pH can be adjusted with acids or bases, such as hydrochloric acid or sodium hydroxide. The parenteral preparation can be enclosed in ampoules, disposable syringes or multiple dose vials made of glass or plastic.
Oral compositions generally include an inert diluent or an edible carrier. For the purpose of oral therapeutic administration, the active compound can be incorporated with excipients and used in the form of tablets, troches, or capsules, e.g., gelatin capsules. Oral compositions can also be prepared using a fluid carrier for use as a mouthwash. Pharmaceutically compatible binding agents, and/or adjuvant materials can be included as part of the composition. The tablets, pills, capsules, troches and the like can contain any of the following ingredients, or compounds of a similar nature: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate or Sterotes; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring.
Pharmaceutical compositions suitable for injectable use include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion. For intravenous administration, suitable carriers include physiological saline, bacteriostatic water, Cremophor E™ (BASF, Parsippany, N.J.) or phosphate buffered saline (PBS). In all cases, the composition must be sterile and should be fluid to the extent that easy syringability exists. It should be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like. In many cases, isotonic agents, for example, sugars, polyalcohols such as mannitol, sorbitol, sodium chloride sometimes are included in the composition. Prolonged absorption of the injectable compositions can be brought about by including in the composition an agent which delays absorption, for example, aluminum monostearate and gelatin.
Sterile injectable solutions can be prepared by incorporating the active compound in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the active compound into a sterile vehicle which contains a basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, methods of preparation often utilized are vacuum drying and freeze-drying which yields a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.
For administration by inhalation, the compounds are delivered in the form of an aerosol spray from pressured container or dispenser which contains a suitable propellant, e.g., a gas such as carbon dioxide, or a nebulizer.
Systemic administration can also be by transmucosal or transdermal means. For transmucosal or transdermal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art, and include, for example, for transmucosal administration, detergents, bile salts, and fusidic acid derivatives. Transmucosal administration can be accomplished through the use of nasal sprays or suppositories. For transdermal administration, the active compounds are formulated into ointments, salves, gels, or creams as generally known in the art. Molecules can also be prepared in the form of suppositories (e.g., with conventional suppository bases such as cocoa butter and other glycerides) or retention enemas for rectal delivery.
In one embodiment, active molecules are prepared with carriers that will protect the compound against rapid elimination from the body, such as a controlled release formulation, including implants and microencapsulated delivery systems. Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid. Methods for preparation of such formulations will be apparent to those skilled in the art. Materials can also be obtained commercially from Alza Corporation and Nova Pharmaceuticals, Inc. Liposomal suspensions (including liposomes targeted to infected cells with monoclonal antibodies to viral antigens) can also be used as pharmaceutically acceptable carriers. These can be prepared according to methods known to those skilled in the art, for example, as described in U.S. Pat. No. 4,522,811.
It is advantageous to formulate oral or parenteral compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the subject to be treated; each unit containing a predetermined quantity of active compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier.
Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD50/ED50. Molecules which exhibit high therapeutic indices often are utilized. While molecules that exhibit toxic side effects may be used, care should be taken to design a delivery system that targets such compounds to the site of affected tissue in order to minimize potential damage to uninfected cells and, thereby, reduce side effects.
The data obtained from the cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such molecules often lies within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any molecules used in the methods described herein, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range that includes the IC50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography.
As defined herein, a therapeutically effective amount of protein or polypeptide (i.e., an effective dosage) ranges from about 0.001 to 30 mg/kg body weight, sometimes about 0.01 to 25 mg/kg body weight, often about 0.1 to 20 mg/kg body weight, and more often about 1 to 10 mg/kg, 2 to 9 mg/kg, 3 to 8 mg/kg, 4 to 7 mg/kg, or 5 to 6 mg/kg body weight. The protein or polypeptide can be administered one time per week for between about 1 to 10 weeks, sometimes between 2 to 8 weeks, often between about 3 to 7 weeks, and more often for about 4, 5, or 6 weeks. The skilled artisan will appreciate that certain factors may influence the dosage and timing required to effectively treat a subject, including but not limited to the severity of the disease or disorder, previous treatments, the general health and/or age of the subject, and other diseases present. Moreover, treatment of a subject with a therapeutically effective amount of a protein, polypeptide, or antibody can include a single treatment, or sometimes can include a series of treatments.
With regard to polypeptide formulations, featured herein is a method for treating breast cancer in a subject, which comprises contacting one or more cells in the subject with a first ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide, where the subject comprises a second ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide having one or more polymorphic variations associated with cancer, and where the first polypeptide comprises fewer polymorphic variations associated with cancer than the second polypeptide. The first and second polypeptides are encoded by a nucleic acid which comprises a nucleotide sequence selected from the group consisting of the nucleotide sequence of SEQ ID NO: 1-17; a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-17; a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-17 and a nucleotide sequence 90% or more identical to a nucleotide sequence of SEQ ID NO: 1-17. The subject is often a human.
For antibodies, a dosage of 0.1 mg/kg of body weight (generally 10 mg/kg to 20 mg/kg) is often utilized. If the antibody is to act in the brain, a dosage of 50 mg/kg to 100 mg/kg is often appropriate. Generally, partially human antibodies and fully human antibodies have a longer half-life within the human body than other antibodies. Accordingly, lower dosages and less frequent administration is often possible. Modifications such as lipidation can be used to stabilize antibodies and to enhance uptake and tissue penetration (e.g., into the brain). A method for lipidation of antibodies is described by Cruikshank et al., J. Acquired Immune Deficiency Syndromes and Human Retrovirology 14: 193 (1997).
Antibody conjugates can be used for modifying a given biological response, the drug moiety is not to be construed as limited to classical chemical therapeutic agents. For example, the drug moiety may be a protein or polypeptide possessing a desired biological activity. Such proteins may include, for example, a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin; a polypeptide such as tumor necrosis factor, .alpha.-interferon, .beta.-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator; or, biological response modifiers such as, for example, lymphokines, interleukin-1 (“IL-1”), interleukin-2 (“IL-2”), interleukin-6 (“IL-6”), granulocyte macrophage colony stimulating factor (“GM-CSF”), granulocyte colony stimulating factor (“G-CSF”), or other growth factors. Alternatively, an antibody can be conjugated to a second antibody to form an antibody heteroconjugate as described by Segal in U.S. Pat. No. 4,676,980.
For compounds, exemplary doses include milligram or microgram amounts of the compound per kilogram of subject or sample weight, for example, about 1 microgram per kilogram to about 500 milligrams per kilogram, about 100 micrograms per kilogram to about 5 milligrams per kilogram, or about 1 microgram per kilogram to about 50 micrograms per kilogram. It is understood that appropriate doses of a small molecule depend upon the potency of the small molecule with respect to the expression or activity to be modulated. When one or more of these small molecules is to be administered to an animal (e.g., a human) in order to modulate expression or activity of a polypeptide or nucleic acid described herein, a physician, veterinarian, or researcher may, for example, prescribe a relatively low dose at first, subsequently increasing the dose until an appropriate response is obtained. In addition, it is understood that the specific dose level for any particular animal subject will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, gender, and diet of the subject, the time of administration, the route of administration, the rate of excretion, any drug combination, and the degree of expression or activity to be modulated.
ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid molecules can be inserted into vectors and used in gene therapy methods for treating breast cancer. Featured herein is a method for treating breast cancer in a subject, which comprises contacting one or more cells in the subject with a first ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid, where genomic DNA in the subject comprises a second ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid comprising one or more polymorphic variations associated with breast cancer, and where the first nucleic acid comprises fewer polymorphic variations associated with breast cancer. The first and second nucleic acids typically comprise a nucleotide sequence selected from the group consisting of the nucleotide sequence of SEQ ID NO: 1-7; a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-7; a nucleotide sequence that is 90% or more identical to the nucleotide sequence of SEQ ID NO: 1-7, and a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence in SEQ ID NO: 1-7. The subject often is a human.
Gene therapy vectors can be delivered to a subject by, for example, intravenous injection, local administration (see U.S. Pat. No. 5,328,470) or by stereotactic injection (see e.g., Chen et al., (1994) Proc. Natl. Acad. Sci. USA 91: 3054-3057). Pharmaceutical preparations of gene therapy vectors can include a gene therapy vector in an acceptable diluent, or can comprise a slow release matrix in which the gene delivery vehicle is imbedded. Alternatively, where the complete gene delivery vector can be produced intact from recombinant cells (e.g., retroviral vectors) the pharmaceutical preparation can include one or more cells which produce the gene delivery system. Examples of gene delivery vectors are described herein.
Pharmaceutical compositions can be included in a container, pack, or dispenser together with instructions for administration.
Pharmaceutical compositions of active ingredients can be administered by any of the paths described herein for therapeutic and prophylactic methods for treating breast cancer. With regard to both prophylactic and therapeutic methods of treatment, such treatments may be specifically tailored or modified, based on knowledge obtained from pharmacogenomic analyses described herein. As used herein, the term “treatment” is defined as the application or administration of a therapeutic agent to a patient, or application or administration of a therapeutic agent to an isolated tissue or cell line from a patient, who has a disease, a symptom of disease or a predisposition toward a disease, with the purpose to cure, heal, alleviate, relieve, alter, remedy, ameliorate, improve or affect the disease, the symptoms of disease or the predisposition toward disease. A therapeutic agent includes, but is not limited to, small molecules, peptides, antibodies, ribozymes and antisense oligonucleotides.
Administration of a prophylactic agent can occur prior to the manifestation of symptoms characteristic of the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 aberrance, such that a disease or disorder is prevented or, alternatively, delayed in its progression. Depending on the type of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 aberrance, for example, a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecule, ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 agonist, or ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 antagonist agent can be used for treating the subject. The appropriate agent can be determined based on screening assays described herein.
As discussed, successful treatment of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 disorders can be brought about by techniques that serve to inhibit the expression or activity of target gene products. For example, compounds (e.g., an agent identified using an assays described above) that exhibit negative modulatory activity can be used to prevent and/or treat breast cancer. Such molecules can include, but are not limited to peptides, phosphopeptides, small organic or inorganic molecules, or antibodies (including, for example, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and FAb, F(ab′)2 and FAb expression library fragments, scFV molecules, and epitope-binding fragments thereof).
Further, antisense and ribozyme molecules that inhibit expression of the target gene can also be used to reduce the level of target gene expression, thus effectively reducing the level of target gene activity. Still further, triple helix molecules can be utilized in reducing the level of target gene activity. Antisense, ribozyme and triple helix molecules are discussed above.
It is possible that the use of antisense, ribozyme, and/or triple helix molecules to reduce or inhibit mutant gene expression can also reduce or inhibit the transcription (triple helix) and/or translation (antisense, ribozyme) of mRNA produced by normal target gene alleles, such that the concentration of normal target gene product present can be lower than is necessary for a normal phenotype. In such cases, nucleic acid molecules that encode and express target gene polypeptides exhibiting normal target gene activity can be introduced into cells via gene therapy method. Alternatively, in instances where the target gene encodes an extracellular polypeptide, normal target gene polypeptide often is co-administered into the cell or tissue to maintain the requisite level of cellular or tissue target gene activity.
Another method by which nucleic acid molecules may be utilized in treating or preventing a disease characterized by ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 expression is through the use of aptamer molecules specific for ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. Aptamers are nucleic acid molecules having a tertiary structure which permits them to specifically bind to polypeptide ligands (see, e.g., Osborne, et al., Curr. Opin. Chem. Biol. 1(1): 5-9 (1997); and Patel, D. J., Curr. Opin. Chem. Biol. June; 1(1): 32-46 (1997)). Since nucleic acid molecules may in many cases be more conveniently introduced into target cells than therapeutic polypeptide molecules may be, aptamers offer a method by which ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide activity may be specifically decreased without the introduction of drugs or other molecules which may have pluripotent effects.
Antibodies can be generated that are both specific for target gene product and that reduce target gene product activity. Such antibodies may, therefore, by administered in instances whereby negative modulatory techniques are appropriate for the treatment of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 disorders. For a description of antibodies, see the Antibody section above.
In circumstances where injection of an animal or a human subject with a ICAM, MAPK10, KIAA0861, NUMA1; GALE, DPF3 or LOC145197 polypeptide or epitope for stimulating antibody production is harmful to the subject, it is possible to generate an immune response against ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 through the use of anti-idiotypic antibodies (see, for example, Herlyn, D., Ann. Med.; 31(1): 66-78 (1999); and Bhattacharya-Chatterjee & Foon, Cancer Treat. Res.; 94: 51-68 (1998)). If an anti-idiotypic antibody is introduced into a mammal or human subject, it should stimulate the production of anti-anti-idiotypic antibodies, which should be specific to the ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide. Vaccines directed to a disease characterized by ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 expression may also be generated in this fashion.
In instances where the target antigen is intracellular and whole antibodies are used, internalizing antibodies may be utilized. Lipofectin or liposomes can be used to deliver the antibody or a fragment of the Fab region that binds to the target antigen into cells. Where fragments of the antibody are used, the smallest inhibitory fragment that binds to the target antigen often is utilized. For example, peptides having an amino acid sequence corresponding to the Fv region of the antibody can be used. Alternatively, single chain neutralizing antibodies that bind to intracellular target antigens can also be administered. Such single chain antibodies can be administered, for example, by expressing nucleotide sequences encoding single-chain antibodies within the target cell population (see e.g., Marasco et al., Proc. Natl. Acad. Sci. USA 90: 7889-7893 (1993)).
ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 molecules and compounds that inhibit target gene expression, synthesis and/or activity can be administered to a patient at therapeutically effective doses to prevent, treat or ameliorate ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 disorders. A therapeutically effective dose refers to that amount of the compound sufficient to result in amelioration of symptoms of the disorders.
Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD50/ED50. Compounds that exhibit large therapeutic indices often are utilized. While compounds that exhibit toxic side effects can be used, care should be taken to design a delivery system that targets such compounds to the site of affected tissue in order to minimize potential damage to uninfected cells and, thereby, reduce side effects.
Data obtained from cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such compounds often lies within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage can vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in a method described herein, the therapeutically effective dose can be estimated initially from cell culture assays. A dose can be formulated in animal models to achieve a circulating plasma concentration range that includes the IC50 (i.e., the concentration of the test compound that achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma can be measured, for example, by high performance liquid chromatography.
Another example of effective dose determination for an individual is the ability to directly assay levels of “free” and “bound” compound in the serum of the test subject. Such assays may utilize antibody mimics and/or “biosensors” that have been created through molecular imprinting techniques.
The compound which is able to modulate ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activity is used as a template, or “imprinting molecule”, to spatially organize polymerizable monomers prior to their polymerization with catalytic reagents. The subsequent removal of the imprinted molecule leaves a polymer matrix which contains a repeated “negative image” of the compound and is able to selectively rebind the molecule under biological assay conditions. A detailed review of this technique can be seen in Ansell et al., Current Opinion in Biotechnology 7: 89-94 (1996) and in Shea, Trends in Polymer Science 2: 166-173 (1994). Such “imprinted” affinity matrixes are amenable to ligand-binding assays, whereby the immobilized monoclonal antibody component is replaced by an appropriately imprinted matrix. An example of the use of such matrixes in this way can be seen in Vlatakis, et al., Nature 361: 645-647 (1993). Through the use of isotope-labeling, the “free” concentration of compound which modulates the expression or activity of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 can be readily monitored and used in calculations of IC50. Such “imprinted” affinity matrixes can also be designed to include fluorescent groups whose photon-emitting properties measurably change upon local and selective binding of target compound. These changes can be readily assayed in real time using appropriate fiberoptic devices, in turn allowing the dose in a test subject to be quickly optimized based on its individual IC50. A rudimentary example of such a “biosensor” is discussed in Kriz et al., Analytical Chemistry 67: 2142-2144 (1995).
Provided herein are methods of modulating ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 expression or activity for therapeutic purposes. Accordingly, in an exemplary embodiment, the modulatory method involves contacting a cell with a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 or agent that modulates one or more of the activities of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide activity associated with the cell. An agent that modulates ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide activity can be an agent as described herein, such as a nucleic acid or a polypeptide, a naturally-occurring target molecule of a ICAM, MAPK10, KIAA0861, NUMA41, GALE, DPF3 or LOC145197 polypeptide (e.g., a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 substrate or receptor), a ICAM, MAPK10, KIAA0861, NUMA41, GALE, DPF3 or LOC145197 antibody, a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 agonist or antagonist, a peptidomimetic of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 agonist or antagonist, or other small molecule.
In one embodiment, the agent stimulates one or more ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activities. Examples of such stimulatory agents include active ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide and a nucleic acid molecule encoding ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197. In another embodiment, the agent inhibits one or more ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activities. Examples of such inhibitory agents include antisense ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 nucleic acid molecules, anti-ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 antibodies, and ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 inhibitors, and competitive inhibitors that target ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197. These modulatory methods can be performed in vitro (e.g., by culturing the cell with the agent) or, alternatively, in vivo (e.g., by administering the agent to a subject). As such, provided are methods of treating an individual afflicted with a disease or disorder characterized by aberrant or unwanted expression or activity of a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or nucleic acid molecule. In one embodiment, the method involves administering an agent (e.g., an agent identified by a screening assay described herein), or combination of agents that modulates (e.g., upregulates or downregulates) ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 expression or activity. In another embodiment, the method involves administering a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polypeptide or nucleic acid molecule as therapy to compensate for reduced, aberrant, or unwanted ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 expression or activity.
Stimulation of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activity is desirable in situations in which ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 is abnormally downregulated and/or in which increased ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activity is likely to have a beneficial effect. For example, stimulation of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activity is desirable in situations in which a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 is downregulated and/or in which increased ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activity is likely to have a beneficial effect. Likewise, inhibition of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activity is desirable in situations in which ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 is abnormally upregulated and/or in which decreased ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 activity is likely to have a beneficial effect.
Methods of Treatment
In another aspect, provided are methods for identifying a risk of cancer in an individual as described herein and, if a genetic predisposition is identified, treating that individual to delay or reduce or prevent the development of cancer. Such a procedure can be used to treat breast cancer. Optionally, treating an individual for cancer may include inhibiting cellular proliferation, inhibiting metastasis, inhibiting invasion, or preventing tumor formation or growth as defined herein. Suitable treatments to prevent or reduce or delay breast cancer focus on inhibiting additional cellular proliferation, inhibiting metastasis, inhibiting invasion, and preventing further tumor formation or growth. Treatment usually includes surgery followed by radiation therapy. Surgery may be a lumpectomy or a mastectomy (e.g., total, simple or radical). Even if the doctor removes all of the cancer that can be seen at the time of surgery, the patient may be given radiation therapy, chemotherapy, or hormone therapy after surgery to try to kill any cancer cells that may be left. Radiation therapy is the use of x-rays or other types of radiation to kill cancer cells and shrink tumors. Radiation therapy may use external radiation (using a machine outside the body) or internal radiation. Chemotherapy is the use of drugs to kill cancer cells. Chemotherapy may be taken by mouth, or it may be put into the body by inserting a needle into a vein or muscle. Hormone therapy often focuses on estrogen and progesterone, which are hormones that affect the way some cancers grow. If tests show that the cancer cells have estrogen and progesterone receptors (molecules found in some cancer cells to which estrogen and progesterone will attach), hormone therapy is used to block the way these hormones help the cancer grow. Hormone therapy with tamoxifen is often given to patients with early stages of breast cancer and those with metastatic breast cancer. Other types of treatment being tested in clinical trials include sentinel lymph node biopsy followed by surgery and high-dose chemotherapy with bone marrow transplantation and peripheral blood stem cell transplantation. Any preventative/therapeutic treatment known in the art may be prescribed and/or administered, including, for example, surgery, chemotherapy and/or radiation treatment, and any of the treatments may be used in combination with one another to treat or prevent breast cancer (e.g., surgery followed by radiation therapy).
Also provided are methods of preventing or treating cancer comprising providing an individual in need of such treatment with a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 inhibitor that reduces or inhibits the overexpression of mutant ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 (e.g., a ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 polynucleotide with an allele that is associated with cancer). Included herein are methods of reducing or blocking the expression of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 comprising providing or administering to individuals in need of reducing or blocking the expression of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 a pharmaceutical or physiologically acceptable composition comprising a molecule capable of inhibiting expression of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197, e.g., a siRNA molecule. Also included herein are methods of reducing or blocking the expression of secondary regulatory genes regulated by ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 that play a role in oncogenesis which comprises introducing competitive inhibitors that target the effect of ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 or LOC145197 on these regulatory genes or that block the binding of positive factors necessary for the expression of these regulatory genes.
The examples set forth below are intended to illustrate but not limit the invention.
EXAMPLES
In the following studies a group of subjects were selected according to specific parameters relating to breast cancer. Nucleic acid samples obtained from individuals in the study group were subjected to genetic analysis, which identified associations between breast cancer and certain polymorphic variants in ICAM region, MAPK10, KIAA0861, NUMA1/FLJ20625/LOC220074 region, and HT014/LOC148902/LYPLA2/GALE region loci (herein referred to as “target genes”, “target nucleotides”, “target polypeptides” or simply “targets”). In addition, methods are described for combining information from multiple SNPs from the target genes found to be independently associated with breast cancer status in a case-control study. The resulting model permits a powerful, more informative quantitation of the combined value of the SNPs for predicting breast cancer susceptibility.
Example 1
Samples and Pooling Strategies
Sample Selection
Blood samples were collected from individuals diagnosed with breast cancer, which were referred to as case samples. Also, blood samples were collected from individuals not diagnosed with breast cancer as gender and age-matched controls. All of the samples were of German/German descent. A database was created that listed all phenotypic trait information gathered from individuals for each case and control sample. Genomic DNA was extracted from each of the blood samples for genetic analyses.
DNA Extraction from Blood Samples
Six to ten milliliters of whole blood was transferred to a 50 ml tube containing 27 ml of red cell lysis solution (RCL). The tube was inverted until the contents were mixed. Each tube was incubated for 10 minutes at room temperature and inverted once during the incubation. The tubes were then centrifuged for 20 minutes at 3000×g and the supernatant was carefully poured off. 100-200 μl of residual liquid was left in the tube and was pipetted repeatedly to resuspend the pellet in the residual supernatant. White cell lysis solution (WCL) was added to the tube and pipetted repeatedly until completely mixed. While no incubation was normally required, the solution was incubated at 37° C. or room temperature if cell clumps were visible after mixing until the solution was homogeneous. 2 ml of protein precipitation was added to the cell lysate. The mixtures were vortexed vigorously at high speed for 20 sec to mix the protein precipitation solution uniformly with the cell lysate, and then centrifuged for 10 minutes at 3000×g. The supernatant containing the DNA was then poured into a clean 15 ml tube, which contained 7 ml of 100% isopropanol. The samples were mixed by inverting the tubes gently until white threads of DNA were visible. Samples were centrifuged for 3 minutes at 2000×g and the DNA was visible as a small white pellet. The supernatant was decanted and 5 ml of 70% ethanol was added to each tube. Each tube was inverted several times to wash the DNA pellet, and then centrifuged for 1 minute at 2000×g. The ethanol was decanted and each tube was drained on clean absorbent paper. The DNA was dried in the tube by inversion for 10 minutes, and then 1000 μl of 1×TE was added. The size of each sample was estimated, and less TE buffer was added during the following DNA hydration step if the sample was smaller. The DNA was allowed to rehydrate overnight at room temperature, and DNA samples were stored at 2-8° C.
DNA was quantified by placing samples on a hematology mixer for at least 1 hour. DNA was serially diluted (typically 1: 80, 1: 160, 1: 320, and 1: 640 dilutions) so that it would be within the measurable range of standards. 125 μl of diluted DNA was transferred to a clear U-bottom microtitre plate, and 125 μl of 1×TE buffer was transferred into each well using a multichannel pipette. The DNA and 1×TE were mixed by repeated pipetting at least 15 times, and then the plates were sealed. 50 μl of diluted DNA was added to wells A5-H12 of a black flat bottom microtitre plate. Standards were inverted six times to mix them, and then 50 μl of 1×TE buffer was pipetted into well A1, 1000 ng/ml of standard was pipetted into well A2, 500 ng/ml of standard was pipetted into well A3, and 250 ng/ml of standard was pipetted into well A4. PicoGreen (Molecular Probes, Eugene, Oreg.) was thawed and freshly diluted 1: 200 according to the number of plates that were being measured. PicoGreen was vortexed and then 50 μl was pipetted into all wells of the black plate with the diluted DNA. DNA and PicoGreen were mixed by pipetting repeatedly at least 10 times with the multichannel pipette. The plate was placed into a Fluoroskan Ascent Machine (microplate fluorometer produced by Labsystems) and the samples were allowed to incubate for 3 minutes before the machine was run using filter pairs485 nm excitation and 538 nm emission wavelengths. Samples having measured DNA concentrations of greater than 450 ng/μl were re-measured for conformation. Samples having measured DNA concentrations of 20 ng/μl or less were re-measured for confirmation.
Pooling Strategies
Samples were placed into one of two groups based on disease status. The two groups were female case groups and female control groups. A select set of samples from each group were utilized to generate pools, and one pool was created for each group. Each individual sample in a pool was represented by an equal amount of genomic DNA. For example, where 25 ng of genomic DNA was utilized in each PCR reaction and there were 200 individuals in each pool, each individual would provide 125 pg of genomic DNA. Inclusion or exclusion of samples for a pool was based upon the following criteria: the sample was derived from an individual characterized as Caucasian; the sample was derived from an individual of German paternal and maternal descent; the database included relevant phenotype information for the individual; case samples were derived from individuals diagnosed with breast cancer; control samples were derived from individuals free of cancer and no family history of breast cancer; and sufficient genomic DNA was extracted from each blood sample for all allelotyping and genotyping reactions performed during the study. Phenotype information included pre- or post-menopausal, familial predisposition, country or origin of mother and father, diagnosis with breast cancer (date of primary diagnosis, age of individual as of primary diagnosis, grade or stage of development, occurrence of metastases, e.g., lymph node metastases, organ metastases), condition of body tissue (skin tissue, breast tissue, ovary tissue, peritoneum tissue and myometrium), method of treatment (surgery, chemotherapy, hormone therapy, radiation therapy). Samples that met these criteria were added to appropriate pools based on gender and disease status.
The selection process yielded the pools set forth in Table 1, which were used in the studies that follow:
TABLE 1
|
|
Female CASEFemale CONTROL
|
|
Pool size272276
(Number)
Pool Criteriacasecontrol
(ex: case/control)
Mean Age59.655.4
(ex: years)
|
Example 2
Association of Polymorphic Variants with Breast cancer
A whole-genome screen was performed to identify particular SNPs associated with occurrence of breast cancer. As described in Example 1, two sets of samples were utilized, which included samples from female individuals having breast cancer (breast cancer cases) and samples from female individuals not having cancer (female controls). The initial screen of each pool was performed in an allelotyping study, in which certain samples in each group were pooled. By pooling DNA from each group, an allele frequency for each SNP in each group was calculated. These allele frequencies were then compared to one another. Particular SNPs were considered as being associated with breast cancer when allele frequency differences calculated between case and control pools were statistically significant. SNP disease association results obtained from the allelotyping study were then validated by genotyping each associated SNP across all samples from each pool. The results of the genotyping were then analyzed, allele frequencies for each group were calculated from the individual genotyping results, and a p-value was calculated to determine whether the case and control groups had statistically significantly differences in allele frequencies for a particular SNP. When the genotyping results agreed with the original allelotyping results, the SNP disease association was considered validated at the genetic level.
SNP Panel Used for Genetic Analyses
A whole-genome SNP screen began with an initial screen of approximately 25,000 SNPs over each set of disease and control samples using a pooling approach. The pools studied in the screen are described in Example 1. The SNPs analyzed in this study were part of a set of 25,488 SNPs confirmed as being statistically polymorphic as each is characterized as having a minor allele frequency of greater than 10%. The SNPs in the set reside in genes or in close proximity to genes, and many reside in gene exons. Specifically, SNPs in the set are located in exons, introns, and within 5,000 base-pairs upstream of a transcription start site of a gene. In addition, SNPs were selected according to the following criteria: they are located in ESTs; they are located in Locuslink or Ensemble genes; and they are located in Genomatix promoter predictions. SNPs in the set also were selected on the basis of even spacing across the genome, as depicted in Table 2.
A case-control study design using a whole genome association strategy involving approximately 28,000 single nucleotide polymorphisms (SNPs) was employed. Approximately 25,000 SNPs were evenly spaced in gene-based regions of the human genome with a median inter-marker distance of about 40,000 base pairs. Additionally, approximately 3,000 SNPs causing amino acid substitutions in genes described in the literature as candidates for various diseases were used. The case-control study samples were of female German origin (German paternal and maternal descent) 548 individuals were equally distributed in two groups (female controls and female cases). The whole genome association approach was first conducted on 2 DNA pools representing the 2 groups. Significant markers were confirmed by individual genotyping.
TABLE 2
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|
General StatisticsSpacing Statistics
|
|
Total # of SNPs28,532Median34,424bp
# of Exonic SNPs8,497(30%)Minimum*1,000bp
# SNPs with26,625(93%)Maximum*3,000,000bp
refSNP ID
Gene Coverage23,874Mean122,412bp
ChromosomeAllStd Deviation354,bp
Coverage
|
*Excludes outliers
|
Allelotyping and Genotyping Results
The genetic studies summarized above and described in more detail below identified allelic variants associated with breast cancer. The allelic variants identified from the SNP panel described in Table 2 are summarized below in Table 3.
TABLE 3
|
|
Chromo-Position
SNPChromo-somein SEQ IDContigContigSequenceSequenceAllelic
ReferencesomePositionNO: 1-7IdentificationPositionIdentificationLocusPositionVariability
|
|
11549918191026393844247NT_0112951665740NM_003259ICAM regionExonC/T
(I301V)
154199848740853936424NT_01635411444849NM_002753MAPK10intronC/T
2001449318404984948563NT_00561289424094NM_015078KIAA0861intronG/C
NM_006185NUMA1upstreamT/C
673478117152541249002NT_0339271998133NM_017907FLJ20625downstream
NM_145309LOC220074intron
NM_000403GALEdownstreamA/G
423712358360487877NT_0046104917379NM_020362HT0143′utr
NM_007260LYPLA2upstream
1990440147126719540095NT_02643753197195NM_012074DPF3intronG/C
10547451499900494NT_02643781830494XM_096734LOC145197upstreamG/A
|
Table 3 includes information pertaining to the incident polymorphic variant associated with breast cancer identified herein. Public information pertaining to the polymorphism and the genomic sequence that includes the polymorphism are indicated. The genomic sequences identified in Table 3 may be accessed at the http address www.ncbi.nih.gov/entrez/query.fcgi, for example, by using the publicly available SNP reference number (e.g., rs1541998). The chromosome position refers to the position of the SNP within NCBI's Genome Build 34, which may be accessed at the following http address: www.ncbi.nlm.nih.gov/mapview/map_search.cgi?chr=hum_chr.inf&query=. The “Contig Position” provided in Table 3 corresponds to a nucleotide position set forth in the contig sequence, and designates the polymorphic site corresponding to the SNP reference number. The sequence containing the polymorphisms also may be referenced by the “Sequence Identification” set forth in Table 3. The “Sequence Identification” corresponds to cDNA sequence that encodes associated target polypeptides (e.g., NUMA1) of the invention. The position of the SNP within the cDNA sequence is provided in the “Sequence Position” column of Table 3. Also, the allelic variation at the polymorphic site and the allelic variant identified as associated with breast cancer is specified in Table 3. All nucleotide sequences referenced and accessed by the parameters set forth in Table 3 are incorporated herein by reference. The positions for these SNPs are indicated in the tables below and in SEQ ID NO: 1-7.
Assay for Verifying, Allelotyping, and Genotyping SNPs
A MassARRAY™ system (Sequenom, Inc.) was utilized to perform SNP genotyping in a high-throughput fashion. This genotyping platform was complemented by a homogeneous, single-tube assay method (hME™ or homogeneous MassEXTEND™ (Sequenom, Inc.)) in which two genotyping primers anneal to and amplify a genomic target surrounding a polymorphic site of interest. A third primer (the MassEXTEND™ primer), which is complementary to the amplified target up to but not including the polymorphism, was then enzymatically extended one or a few bases through the polymorphic site and then terminated.
For each polymorphism, SpectroDESIGNER™ software (Sequenom, Inc.) was used to generate a set of PCR primers and a MassEXTEND™ primer was used to genotype the polymorphism. Table 4 shows PCR primers and Table 5 shows extension primers used for analyzing polymorphisms. The initial PCR amplification reaction was performed in a 5 μl total volume containing 1×PCR buffer with 1.5 mM MgCl2 (Qiagen), 200 μM each of dATP, dGTP, dCTP, dTTP (Gibco-BRL), 2.5 ng of genomic DNA, 0.1 units of HotStar DNA polymerase (Qiagen), and 200 nM each of forward and reverse PCR primers specific for the polymorphic region of interest.
TABLE 4
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|
PCR Primers
Refer-
enceForwardReverse
SNP IDPCR primerPCR primer
|
11549918GACAGCCACAGCTAGCGCAGATGTTTTCGCCCCCCAGG
GTGAC
|
1541998CTGATTATTCTGATGGTAATGGCCCATGTTAACATTTTCTTC
|
2001449ATGTCAAGTGCACCCACATGAGGAAGAAACTGACGGAAGG
|
673478TAATACAAAGGTGGCAGCAGTTGACAAGGATAAGGACAAG
|
4237GCACATGGCCACATTAACTGGTGGCTGTGGAAATTGGG
TCTTG
|
1990440CCAGGGTGTGTTCTAATACGAAGTCACTAACCCCACACAC
|
1054745GACTTTTAGGTCTGAGTTGGCTTCCTCTAGCAGTGTATTTC
|
Samples were incubated at 95° C. for 15 minutes, followed by 45 cycles of 95° C. for 20 seconds, 56° C. for 30 seconds, and 72° C. for 1 minute, finishing with a 3 minute final extension at 72° C. Following amplification, shrimp alkaline phosphatase (SAP) (0.3 units in a 2 μl volume) (Amersham Pharmacia) was added to each reaction (total reaction volume was 7 μl) to remove any residual dNTPs that were not consumed in the PCR step. Samples were incubated for 20 minutes at 37° C., followed by 5 minutes at 85° C. to denature SAP.
Once the SAP reaction was complete, a primer extension reaction was initiated by adding a polymorphism-specific MassEXTEND™ primer cocktail to each sample. Each MassEXTEND™ cocktail included a specific combination of dideoxynucleotides (ddNTPs) and deoxynucleotides (dNTPs) used to distinguish polymorphic alleles from one another. In Table 5, ddNTPs are shown and the fourth nucleotide not shown is the dNTP.
TABLE 5
|
|
Extend Primers
ReferenceExtendTerm
SNP IDProbeMix
|
11549918CCCAGGGTGACGTTGCAGAACG
|
1541998ATTATTCTGATGGTAATGATCCAGACG
|
2001449CACATGCCTGCTCGCCCCCACT
|
673478AAGGGGAGGTCGACTGGGACT
|
4237GGCATCTGGCAGTCATGGACT
|
1990440CGTCAGCAAATGTGTACCGAACT
|
10547457TTGGTCCATTAGGGAATTAGAACG
|
The Mass EXTEND™ reaction was performed in a total volume of 9 μl, with the addition of 1× ThermoSequenase buffer, 0.576 units of ThermoSequenase (Arnersham Pharmacia), 600 nM MassEXTEND™ primer, 2 mM of ddATP and/or ddCTP and/or ddGTP and/or ddTTP, and 2 mM of dATP or dCTP or dGTP or dTTP. The deoxy nucleotide (dNTP) used in the assay normally was complementary to the nucleotide at the polymorphic site in the amplicon. Samples were incubated at 94° C. for 2 minutes, followed by 55 cycles of 5 seconds at 94° C., 5 seconds at 52° C., and 5 seconds at 72° C.
Following incubation, samples were desalted by adding 16 μl of water (total reaction volume was 25 μl), 3 mg of SpectroCLEAN™ sample cleaning beads (Sequenom, Inc.) and allowed to incubate for 3 minutes with rotation. Samples were then robotically dispensed using a piezoelectric dispensing device (SpectroJET™ (Sequenom, Inc.)) onto either 96-spot or 384-spot silicon chips containing a matrix that crystallized each sample (SpectroCHIP® (Sequenom, Inc.)). Subsequently, MALDI-TOF mass spectrometry (Biflex and Autoflex MALDI-TOF mass spectrometers (Bruker Daltonics) can be used) and SpectroTYPER RT™ software (Sequenom, Inc.) were used to analyze and interpret the SNP genotype for each sample.
Genetic Analysis
Variations identified in the target genes are provided in their respective genomic sequences (see FIGS. 1-7) Minor allelic frequencies for these polymorphisms was verified as being 10% or greater by determining the allelic frequencies using the extension assay described above in a group of samples isolated from 92 individuals originating from the state of Utah in the United States, Venezuela and France (Coriell cell repositories).
Genotyping results are shown for female pools in Table 6A and 6B. Table 6A shows the orginal genotyping results and Table 6B shows the genotyped results re-analyzed to remove duplicate individuals from the cases and controls (i.e., individuals who were erroneously included more than once as either cases or controls). Therefore, Table 6B represents a more accurate measure of the allele frequencies for this particular SNP. In the subsequent tables, “AF” refers to allelic frequency; and “F case” and “F control” refer to female case and female control groups, respectively.
TABLE 6A
|
|
Breast
Cancer
ReferenceAF FAF FAssoc.
SNP IDcasecontrolp-valueOdds RatioAllele
|
11549918C = 0.651C = 0.5640.00380.69C
T = 0.349T = 0.436
1541998T = 0.780T = 0.8390.01530.69C
C = 0.220C = 0.161
2001449G = 0.703G = 0.7800.00401.49C
C = 0.297C = 0.220
673478T = 0.919T = 0.9530.02381.74C
C = 0.081C = 0.047
4237A = 0.590A = 0.5300.04310.78A
G = 0.410G = 0.470
1990440C = 0.876C = 0.9260.00270.65G
G = 0.124G = 0.074
1054745A = 0.871A = 0.8050.0039A
G = 0.129G = 0.195
|
TABLE 6B
|
|
|
Breast
|
Cancer
|
Reference
AF F
AF F
Assoc.
|
SNP ID
case
control
p-value
Odds Ratio
Allele
|
|
11549918
C = 0.658
C = 0.556
0.0012
0.65
C
|
T = 0.342
T = 0.444
|
1541998
T = 0.771
T = 0.839
0.0070
0.65
C
|
C = 0.229
C = 0.161
|
2001449
G = 0.693
G = 0.782
0.0012
1.59
C
|
C = 0.307
C = 0.218
|
673478
T = 0.916
T = 0.953
0.0171
1.85
C
|
C = 0.084
C = 0.047
|
4237
A = 0.584
A = 0.527
0.0704
0.79
A
|
G = 0.416
G = 0.473
|
1990440
C = 0.879
C = 0.915
0.0692
0.67
G
|
G = 0.121
G = 0.085
|
1054745
A = 0.866
A = 0.801
0.0061
1.60
A
|
G = 0.134
G = 0.199
|
|
The single marker alleles set forth in Table 3 were considered validated, since the genotyping data for the females, males or both pools were significantly associated with breast cancer, and because the genotyping results agreed with the original allelotyping results. Particularly significant associations with breast cancer are indicated by a calculated p-value of less than 0.05 for genotype results, which are set forth in bold text.
Odds ratio results are shown in Tables 6A and 6B. An odds ratio is an unbiased estimate of relative risk which can be obtained from most case-control studies. Relative risk (RR) is an estimate of the likelihood of disease in the exposed group (susceptibility allele or genotype carriers) compared to the unexposed group (not carriers). It can be calculated by the following equation:
RR=IA/Ia
- IA is the incidence of disease in the A carriers and Ia is the incidence of disease in the non-carriers.
- RR>1 indicates the A allele increases disease susceptibility.
- RR≦1 indicates the a allele increases disease susceptibility.
For example, RR=1.5 indicates that carriers of the A allele have 1.5 times the risk of disease than 50% more likely to get the disease.
Case-control studies do not allow the direct estimation of IA and Ia, therefore relative risk cannot be directly estimated. However, the odds ratio (OR) can be calculated using the following equation:
OR=(nDAnda)/(ndAnDa)=pDA(1−pdA)/pdA(131 pDA), or
- OR=((case f)/(1−case f))/((control f)/(1−control f)), where f=susceptibility allele frequency.
An odds ratio can be interpreted in the same way a relative risk is interpreted and can be directly estimated using the data from case-control studies, i.e., case and control allele frequencies. The higher the odds ratio value, the larger the effect that particular allele has on the development of breast cancer. Possessing an allele associated with a relatively high odds ratio translates to having a higher risk of developing or having breast cancer.
Example 3
Samples and Pooling Strategies for the Replication Samples
The SNPs of Table 3 were genotyped again in a collection of replication samples to further validate its association with breast cancer. Like the original study population described in Examples 1 and 2, the replication samples consisted of females diagnosed with breast cancer (cases) and females without cancer (controls). The case and control samples were selected and genotyped as described below.
Pooling Strategies
Samples were placed into one of two groups based on disease status. The two groups were female case groups and female control groups. A select set of samples from each group were utilized to generate pools, and one pool was created for each group. Each individual sample in a pool was represented by an equal amount of genomic DNA. For example, where 25 ng of genomic DNA was utilized in each PCR reaction and there were 190 individuals in each pool (i.e., 190 cases and 190 controls), each individual would provide 125 pg of genomic DNA. Inclusion or exclusion of samples for a pool was based upon the following criteria: the sample was derived from a female individual characterized as Caucasian from Australia; case samples were derived from individuals diagnosed with breast cancer; control samples were derived from individuals free of cancer and no family history of breast cancer; and sufficient genomic DNA was extracted from each blood sample for all allelotyping and genotyping reactions performed during the study. Samples in the pools also were age-matched. Samples that met these criteria were added to appropriate pools based on gender and disease status.
The selection process yielded the “Griffith” samples set forth in Table 7A and the “Kiechle” samples set forth in Table 7B, which were used in the studies that follow:
TABLE 7A
|
|
Female CASEFemale CONTROL
|
|
Pool size190190
(Number)
Pool Criteriacasecontrol
(ex: case/control)
Mean Age64.5**
(ex: years)
|
** Each case was matched by a control within 5 years of age of the case.
|
TABLE 7B
|
|
|
Female CASE
Female CONTROL
|
|
|
Pool size
195
153
|
(Number)
|
Pool Criteria
case
control
|
(ex: case/control)
|
|
The replication genotyping results are shown in Table 8A for the Griffith samples and in Table 8B for the Kiechle samples. The odds ratio was calculated as described in Example 2.
TABLE 8A
|
|
ReferenceAFAF
SNP IDF caseF controlp-valueOdds Ratio
|
|
11549918C = 0.650C = 0.5840.06240.75
T = 0.350T = 0.416
1541998T = 0.820T = 0.8640.10100.72
C = 0.180C = 0.136
2001449G = 0.685G = 0.7770.0051.59
C = 0.315C = 0.223
673478T = 0.927T = 0.9570.0771.76
C = 0.073C = 0.043
4237A = 0.632A = 0.5770.12601.26
G = 0.368G = 0.423
1990440C = 0.822C = 0.8600.1720.756
G = 0.178G = 0.140
1054745A = 0.894A = 0.9210.2240.726
G = 0.106G = 0.079
|
TABLE 8B
|
|
|
Reference
AF
AF
|
SNP ID
F case
F control
p-value
Odds Ratio
|
|
|
11549918
C = 0.641
C = 0.570
0.066
0.74
|
T = 0.359
T = 0.430
|
1541998
T = 0.811
T = 0.791
0.521
1.14
|
C = 0.189
C = 0.209
|
2001449
G = 0.754
G = 0.716
0.267
0.82
|
C = 0.246
C = 0.284
|
673478
T = 0.942
T = 0.955
0.474
1.30
|
C = 0.058
C = 0.045
|
4237
A = 0.618
A = 0.587
0.429
0.88
|
G = 0.382
G = 0.413
|
1990440
C = 0.889
C = 0.924
0.124
0.66
|
G = 0.111
G = 0.076
|
1054745
A = 0.877
A = 0.819
0.0396
1.57
|
G = 0.123
G = 0.181
|
|
The absence of a statistically significant association in the replication cohort should not be interpreted as minimizing the value of the original finding. There are many reasons why a biologically derived association identified in a sample from one population would not replicate in a sample from another population. The most important reason is differences in population history. Due to bottlenecks and founder effects, there may be common disease predisposing alleles present in one population that are relatively rare in another, leading to a lack of association in the candidate region. Also, because common diseases such as breast cancer are the result of susceptibilities in many genes and many environmental risk factors, differences in population-specific genetic and environmental backgrounds could mask the effects of a biologically relevant allele. For these and other reasons, statistically strong results in the original, discovery sample that did not replicate in the replication sample may be further evaluated in additional replication cohorts and experimental systems.
Example 4
ICAM Region Proximal SNPs
It has been discovered that a polymorphic variation (rs11549918) in a region that encodes ICAM1, ICAM2 and ICAM5 is associated with the occurrence of breast cancer (see Examples 1 and 2). Subsequently, SNPs proximal to the incident SNP (rs1549918) were identified and allelotyped in breast cancer sample sets and control sample sets as described in Examples 1 and 2. Approximately 195 allelic variants located within the ICAM region were identified and allelotyped. The polymorphic variants are set forth in Table 9. The chromosome position provided in column four of Table 9 is based on Genome “Build 34” of NCBI's GenBank.
TABLE 9
|
|
Position inChromosomeAlleleGenomeDeduced
dbSNP rs#SEQ ID NO: 1ChromosomePositionVariantsLetterIupac
|
|
28844872301910219830t/ccY
235858042821910223882a/ggR
2304236118441910231444a/caM
1059840118901910231490a/ttW
1059843119051910231505c/tcY
11115119421910231542t/ccY
1059849120541910231654g/aaR
1059855120701910231670t/ccY
5030386214971910241097c/gcS
5030339215371910241137a/ggR
5030387216821910241282t/gtK
5030388220731910241673a/ggR
1799766223931910241993c/—cN
5030389223941910241994a/—aN
5490232271910242827c/aaM
11575070236141910243214c/ggS
5030340236811910243281c/tcY
5030390239371910243537a/ggR
5030391240371910243637a/ggR
3093035243731910243973a/ggR
11667983245891910244189c/tcY
503034124675-246761910244275{circumflex over ( )}ct/—ctNN
10244276
5030342246801910244280t/ggK
5030343247541910244354t/ccY
5030344250531910244653g/agR
5030347260041910245604a/ccM
5030348260231910245623a/gaR
5030349260461910245646t/ccY
5030350261001910245700a/taW
5030351268171910246417t/ccY
5491269401910246540t/aaW
5030352271431910246743g/ccS
5030353271621910246762a/ggR
10420063283281910247928g/aaR
11879117287991910248399g/cgS
5030354291661910248766a/caM
5030355293311910248931a/caM
281428297241910249324c/tcY
5030358297731910249373g/aaR
5030359298621910249462a/ggR
5030392298771910249477t/ccY
5030393301941910249794t/ggK
5030360302581910249858t/ggK
5030394305491910250149a/ggR
281429306481910250248t/ccY
5030361309091910250509t/ccY
5030362309621910250562a/ccM
281430313371910250937g/aaR
281431313451910250945t/ctY
5030395315341910251134c/tcY
5827095319421910251542a/—aN
281432320581910251658g/ccS
5030364321091910251709a/ttW
5030365324011910252001a/gaR
5030368328451910252445g/aaR
5030369328641910252464t/ccY
307380932965-329661910252565{circumflex over ( )}tt/—ttNN
10252566
2358581330111910252611g/ttK
7258215331701910252770c/ttY
5030371335161910253116a/ggR
5030372336081910253208t/ctY
281433336231910253223a/caM
5030374336721910253272c/aaM
5030375337241910253324a/—aN
5030397337871910253387t/ggK
281434340201910253620g/aaR
12462944340381910253638c/ggS
5030398341901910253790c/gcS
5030378347061910254306c/gcS
12459133347781910254378t/ggK
5030399355531910255153a/ggR
5492356901910255290g/cgS
1800019361731910255773a/ccM
1799969361921910255792g/agR
5493361941910255794t/ggK
5030381363081910255908c/tcY
5494363171910255917c/tcY
3093033364311910256031g/agR
5495364961910256096g/agR
1801714366081910256208c/tcY
2071441367081910256308c/tcY
5496368471910256447a/ggR
5497368681910256468a/ggR
5030382370831910256683g/aaR
5030400371961910256796c/tcY
2071440373731910256973g/agR
5499374651910257065c/tcY
3093032377361910257336t/ccY
1057981379591910257559g/aaR
5500380311910257631a/gaR
5501380911910257691t/ctY
5030383382431910257843t/ccY
281436385311910258131a/ggR
923366386231910258223t/ccY
281437386381910258238c/tcY
3093030388031910258403t/ccY
5030384394891910259089a/ggR
5030385400081910259608g/ccS
3810159407111910260311t/cgR
281438407751910260375t/gtK
3093029409511910260551c/gcS
2735442412181910260818g/cgS
2569693413041910260904c/tcY
281439415101910261110g/cgS
281440417041910261304g/agR
2569694420201910261620c/tcY
11575073422101910261810c/tcY
2569695423021910261902c/gcS
2075741424981910262098g/cgS
11575074425201910262120a/ggR
2569696426071910262207a/ggR
2735439426741910262274t/gtK
2569697429291910262529g/cgS
2075742430071910262607g/cgS
2569698430401910262640c/gcS
11669397432461910262846c/tcY
901886435311910263131t/ctY
885742440231910263623g/aaR
2569699440241910263624t/gtK
11549918443381910263938c/tgR
2569700444991910264099t/ggK
2228615447681910264368a/ggR
ICAM-AA450031910264603c/tcY
2569701453411910264941g/agR
2569702453471910264947t/ctY
2735440455771910265177g/aaR
2569703456271910265227c/gcS
10418913457941910265394a/ggR
1056536462441910265844c/tgR
2569704464691910266069t/ccY
11673661469991910266599g/cgS
10402760472651910266865t/ccY
0475041910267104a/ggR
2569706475471910267147g/agR
2569707476371910267237c/ggS
2436545476911910267291c/aaM
2436546476921910267292a/caM
2916060477881910267388a/ctK
2916059477961910267396t/caR
2916058478001910267400t/aaW
2569708478121910267412a/ggR
735747479691910267569t/ctY
885743480351910267635a/ttW
710845485691910268169c/ggS
2569709488231910268423c/gcS
2569710488381910268438a/gaR
2569711488941910268494c/gcS
2569712489341910268534a/taW
12610026492491910268849a/ggR
4804129495091910269109c/aaM
12150978497181910269318a/gaR
439843499631910269563c/acM
892188511931910270793t/ccY
2291473571811910276781t/ctY
281416601841910279784a/gaR
281417605301910280130t/ccY
882589613541910280954t/cgR
1048941626161910282216t/gcM
281418627851910282385g/cgS
430092663511910285951c/ttY
368835673861910286986a/gaR
2358583673951910286995t/ggK
378395678221910287422c/aaM
395782680281910287628t/ctY
1045384686461910288246t/ggK
281427705201910290120c/ttY
3745264709661910290566t/gcM
281426724511910292051g/agR
281425731991910292799g/tgK
281424743191910293919c/ttY
281423768931910296493c/ttY
281422777551910297355t/ctY
281420793541910298954a/gaR
3745263809011910300501a/gcY
3745262809401910300540t/caR
3745261811111910300711t/caR
3181049825171910302117t/cgR
281412828741910302474t/ctY
3181048849781910304578a/gtY
2230399860031910305603c/gcS
2278442862261910305826g/agR
3181047872061910306806a/gcY
3181046875351910307135t/caR
2304237879681910307568t/ctY
281413881341910307734g/agR
1058154882971910307897a/ccM
3176769884341910308034t/caR
2304238906021910310202g/aaR
2304239907501910310350t/ccY
2304240907921910310392g/aaR
3176768910651910310665a/gcY
3176767911511910310751c/atK
3176766911781910310778c/tgR
281414916851910311285g/agR
281415923931910311993t/ggK
|
Assay for Verifying and Allelotyping SNPs
The methods used to verify and allelotype the proximal SNPs of Table 9 are the same methods described in Examples 1 and 2 herein. The PCR primers and extend primers used in these assays are provided in Table 10 and Table 11, respectively.
TABLE 10
|
|
dbSNP rs#Forward PCR primerReverse PCR primer
|
|
2884487ACGTTGGATGTGTGGCAAATGATGGAACAGACGTTGGATGCCAGAAGTTTGAGATCTGCC
|
2358580ACGTTGGATGTCGCGTGCGTGACGTCATCCACGTTGGATGCGGGAGGTCAAGGCCACTG
|
2304236ACGTTGGATGTCACATCAACAGTGGTACGGACGTTGGATGAGCCTGCCCTACAGCGACTT
|
1059840ACGTTGGATGTCGGCCTGGCTCAGAAGAGGACGTTGGATGACCCCTACCCCACGCTACCCA
|
1059843ACGTTGGATGCCACCCCGTACCACTGTTGAACGTTGGATGTGAGGCTCCCAAGTCGGCCA
|
11115ACGTTGGATGAGGTGACACCTTCCTCGAAGACGTTGGATGTGTGAAGCACCTCTTCTGAG
|
1059849ACGTTGGATGGGAATGGATGCAGAAGCCCGACGTTGGATGAAGCTGAGGCCACAGGGAG
|
1059855ACGTTGGATGAAAAACAAAAAGAGGGAATGACGTTGGATGGGCCATCGCCATTGGGAAG
|
5030386ACGTTGGATGTTGAACTCCTGGGCTCAAGTACGTTGGATGAGACAAAAATCCACCTGGGC
|
5030339ACGTTGGATGTCAAGTGATCCTCCCATCTCACGTTGGATGGGACACAGGAATGAACAGAG
|
5030387ACGTTGGATGAAGAACGGCACCATTGTGGCACGTTGGATGTTCCACTGAGCTCTTGCCCC
|
5030388ACGTTGGATGTCGGAGATCTCCATGGCGAACGTTGGATGACCACGTCGAGGCTGGGTAC
|
1799766ACGTTGGATGGTTTCCCCGCGGAGCCTGGACGTTGGATGTCCCTACGCGCCGAGCCCC
|
5030389ACGTTGGATGAAAAGGAAGGAAGCTGCGTGACGTTGGATGAAGCTAGCTGCCTCAGTTTC
|
5490ACGTTGGATGCCTCTGCTACTCAGAGTTGCACGTTGGATGACTCACCTGGGAACAGAGC
|
11575070ACGTTGGATGTAGCCTTACCTCCTGCCTCAACGTTGGATGACGCAATCTAGCCAAGCAAG
|
5030340ACGTTGGATGATGAGAGGTGTGAACCACCGACGTTGGATGTGGCCGCTATAACGTTTCCC
|
5030390ACGTTGGATGTTATCCGTGGCCCAAAGCTGACGTTGGATGAAAGACCCTCTGACCCCTTC
|
5030391ACGTTGGATGTGTAAGTTTGGGGAACCAGGACGTTGGATGCTGGATCTCAGGCTTTGTTG
|
3093035ACGTTGGATGGGAGACATAGCGAGATTCTGACGTTGGATGTAGAAAGCAGTGCGATCTGG
|
11667983ACGTTGGATGATCTTTGAGTGAGGCAGTGCACGTTGGATGAGGGGCTTATTTGGATCAGG
|
5030341ACGTTGGATGGAATCTGAGGGACCTGATCCACGTTGGATGTTGCAGTGAGCCGAGATCAC
|
5030342ACGTTGGATGTTTTTGAGACGGAGTCTCACACGTTGGATGAGGAGAATCGTTTGAACCTG
|
5030343ACGTTGGATGTGTAGTCCCAGCTACTCAGGACGTTGGATGTGATCTCGGCTCACTGCAAC
|
5030344ACGTTGGATGAAGAAGTCAGGTGGAGACAGACGTTGGATGAAATTGAGGCCCAAAGAGGG
|
5030347ACGTTGGATGAATCTCAGCTCACTGCAACCACGTTGGATGGCCTGTAATCCCAGATACTC
|
5030348ACGTTGGATGGGAGAATCACTTGAACCCGGACGTTGGATGAGTCTCGCTTTGTCACTCAG
|
5030349ACGTTGGATGTCTCGCTTTGTCACTCAGACACGTTGGATGAATCACTTGAACCCGGGAGG
|
5030350ACGTTGGATGCACTGAAGGCCATGCTAAAGACGTTGGATGACTCCAGTCTGAGTGACAAA
|
5030351ACGTTGGATGTGCCAGGTCCTAGAAGAAACACGTTGGATGCGCACATTCCCTTGATGAAC
|
5491ACGTTGGATGTGACATGCAGCACCTCCTGTACGTTGGATGGGAGCAACTCCTTTTTAGGC
|
5030352ACGTTGGATGTACGAGCAAGTGGCAAAGATTACGTTGGATGTGAGTAACTGAGCCCGGAGG
|
5030353ACGTTGGATGTACTGTGAGTAACTGAGCCCACGTTGGATGAGCAAGTGGCAAAGATTCCC
|
10420063ACGTTGGATGATCTCCTGACCTTGTGATCCACGTTGGATGGCCCTGGGATGGCATTTTTC
|
11879117ACGTTGGATGTGGTCAGGCTGGTCTCGAACTACGTTGGATGAAATGTCATGGGCTGGGCAC
|
5030354ACGTTGGATGCTCTCTTCTCATAGCCAGCTACGTTGGATGATTAGGGAAGGGCAGTTTCG
|
5030355ACGTTGGATGGGCCGGAGAATCACTTAAACACGTTGGATGAGAGTTTCACTCTTGTTGCC
|
281428ACGTTGGATGAGTAGCTGGAATTACAGGCGACGTTGGATGGCCAACATGATGAAATCCCG
|
5030358ACGTTGGATGCACAAGGTCAGGAGATCAAGACGTTGGATGCCACGCCTGGCTAATTTTTG
|
5030359ACGTTGGATGCCAAAGTGCTGGGATTACAGACGTTGGATGAAGTCCCCAAAGTAGGAAGG
|
5030392ACGTTGGATGTTCGAAGTCCCCAAAGTAGGACGTTGGATGAAAGTGCTGGGATTACAGGC
|
5030393ACGTTGGATGTAGTCCCAGCTACTCAGGAGACGTTGGATGTGTCATCACGGCTCACTACA
|
5030360ACGTTGGATGTGTAGTGAGCCGTGATGACAACGTTGGATGTCCCAAAGCTACTTGGCCAG
|
5030394ACGTTGGATGTGAGCAGATGCTGACCTTCCACGTTGGATGAAGACCTTCAAAGAGGTTTC
|
281429ACGTTGGATGCGACAGAGCAAGACTGTGTGACGTTGGATGCTTTTCTGCATCTCTGCCTG
|
5030361ACGTTGGATGTATGCTCTCAGCTATCAGGCACGTTGGATGACTCTAGACCTCTGGTGATC
|
5030362ACGTTGGATGCCACAGTCATAGAGGGAGAAACGTTGGATGCCTGATAGCTGAGAGCATAG
|
281430ACGTTGGATGATTACAGGTGTGAGCCACTGACGTTGGATGGCAGGGAGAAATCTTGATGG
|
281431ACGTTGGATGACTGGGATTACAGGTGTGAGACGTTGGATGGGAGAAATCTTGATGGAGGC
|
5030395ACGTTGGATGAACTACTCTGGAGGCTCAAGACGTTGGATGCAGAGTGAGACTCCATCTCA
|
5827095ACGTTGGATGCCCTTCCTCCCATCAATCAAACGTTGGATGATTGCACCACTGCATTCCAG
|
281432ACGTTGGATGTCAGCTATCTAATCCCTGGCACGTTGGATGAGCTGGGACTTTCCTTCTTG
|
5030364ACGTTGGATGTTCTTGAATACGGTCACTGCACGTTGGATGCTGAAGGCTGGATTTACTGG
|
5030365ACGTTGGATGAGCTGGAGGTCAGAGTTTTCACGTTGGATGCCTGAGACCCTGTCTCTAAA
|
5030368ACGTTGGATGTCATCTGAGGTTGGGAGTTCACGTTGGATGCGACACCACACAAGGCTAAT
|
5030369ACGTTGGATGAGGTGGATCATCTGAGGTTGACGTTGGATGGACAGGGTTTCTCCATGTTG
|
3073809ACGTTGGATGACCGTGCCCGGCCTTTTTTTACGTTGGATGATCGAACCACTGCACTCCTG
|
2358581ACGTTGGATGTAAGGCAGGAGGATGGAGTGACGTTGGATGGACAGAGTCTCACTCTGTCG
|
7258215ACGTTGGATGGTTTCACCGTGTTAGCCAGGACGTTGGATGACATGGTGGCTCACGCCTGTA
|
5030371ACGTTGGATGACTGGGATTACAGATGTGAGACGTTGGATGGTGCTTAAAAGGGATGAATC
|
5030372ACGTTGGATGGTACATAAGCAGGAGGTTTCACGTTGGATGTCTGTACAAACAACCATGAC
|
281433ACGTTGGATGACAGAGTCGCTGTACATAAGACGTTGGATGGTACAAACAACCATGACTAC
|
5030374ACGTTGGATGTGTACAGCGACTCTGTCTACACGTTGGATGCTCTGAACCTCAGTTTCCTG
|
5030375ACGTTGGATGTCTCCTACCTTTAATAGCCCACGTTGGATGTTCTTTGCTGTGGGTAAGTG
|
5030397ACGTTGGATGCTGGGTATCAAATGCAGGACACGTTGGATGAGAGTGAGAGTCTCTCTCAG
|
281434ACGTTGGATGTAATCCCAACACTTTGGGGGACGTTGGATGAACACCACGCCTGGCTAATT
|
12462944ACGTTGGATGTTTCACTATATTGGCCAGGCACGTTGGATGTGTAATCCCAACACTTTGGG
|
5030398ACGTTGGATGCCACACGCAGCCTTTTTGTTACGTTGGATGGAACTGTGATCATGCCACTG
|
5030378ACGTTGGATGAGGCTTGTCTTGAACTCCTGACGTTGGATGTGATGGCTCAGGCTGTAATC
|
12459133ACGTTGGATGAAAGTGCTAGGATTACAGCCACGTTGGATGTAAATGAGCCTGGCCTAGAC
|
5030399ACGTTGGATGAGGTCCACTTCACCAGACACACGTTGGATGTAAGGTTCTTGCCCACTGGC
|
5492ACGTTGGATGACCGTGGTCGTGACCTCAGACGTTGGATGAACCTCACCGTGGTGCTGCT
|
1800019ACGTTGGATGACAGCCCGTCCAGGGAACAACGTTGGATGTCCTAGAGGTGGACACGCA
|
1799969ACGTTGGATGTCAACCTCTGGTCCCCCAGTGACGTTGGATGAGGGGACCGTGGTCTGTTC
|
5493ACGTTGGATGTCCTAGAGGTGGACACGCAGACGTTGGATGTGGACCTGGGCCTCCGAGACT
|
5030381ACGTTGGATGTATGGCAACGACTCCTTCTCACGTTGGATGTATTACTGCACACGTCAGCC
|
5494ACGTTGGATGTAAGGCCTCAGTCAGTGTGAACGTTGGATGAGTATTACTGCACACGTCAG
|
3093033ACGTTGGATGAAAGCCTGGAATAGGCACACACGTTGGATGTGCAGACAGTGACCATCTAC
|
5495ACGTTGGATGTCACACTTCACTGTCACCTCACGTTGGATGTGTGCCTATTCCAGGCTTTC
|
1801714ACGTTGGATGCTAGAGCCAAGGTGACGCTGACGTTGGATGTGGCCTTCAGCAGGAGCTGG
|
2071441ACGTTGGATGAGCTTCTCCTGCTCTGCAACACGTTGGATGTCACACAGGACACGAAGCTC
|
5496ACGTTGGATGAAGGTCTTGCCTCCAAGTCCACGTTGGATGACAATCCCTCTCGTCCAGTC
|
5497ACGTTGGATGCTCCATGTCATCTCATCGTGACGTTGGATGAATTTTCTGGCCACGTCCAG
|
5030382ACGTTGGATGCTCACAGAGCACATTCACGGACGTTGGATGAGATCTTGAGGGCACCTACC
|
5030400ACGTTGGATGGGACCTAATGCAATCCTCACACGTTGGATGGCTACCACAGTGATGATGAC
|
2071440ACGTTGGATGACTGCCACCAATATGGGAAGACGTTGGATGAAACCGAACACACAAGCCAC
|
5499ACGTTGGATGGGAAGACATATGCCATGCAGACGTTGGATGATCTGACTGAGGACAATGCC
|
3093032ACGTTGGATGGGCCACTTCTTCTGTAAGTCACGTTGGATGCATGAGGACATACAACTGGG
|
1057981ACGTTGGATGGTACAACTGTACCTGGTGACACGTTGGATGAATGAACATAGGTCTCTGGC
|
5500ACGTTGGATGTTGTACAGGTTGTACACTGCACGTTGGATGAGGTTGGCCAATGAGAAGTC
|
5501ACGTTGGATGCTGTGAACCATTACCAGTCCACGTTGGATGACTTCTCATTGGCCAACCTG
|
5030383ACGTTGGATGATATTCCCTGGGCACTCATGACGTTGGATGTCCCCACCCACATACATTTC
|
281436ACGTTGGATGCATGGTTCACTGCAGTCTTGACGTTGGATGTGTGGTGTTGTGAGCCTATG
|
923366ACGTTGGATGAGGAAGTCTGGGCAATGTTGACGTTGGATGATAGGCTCACAACACCACAC
|
281437ACGTTGGATGATAGGCTCACAACACCACACACGTTGGATGAACACAAAGGAAGTCTGGGC
|
3093030ACGTTGGATGAGAGACCCAGAAGGTCATAGACGTTGGATGCCTCCCCCAAGAAAACATTG
|
5030384ACGTTGGATGTGCGCAGGAAAAACACGCTGACGTTGGATGACTGTCAACTACCCTTCCCC
|
5030385ACGTTGGATGATTAGGAACGGAACACAGGGACGTTGGATGAGAGAGTTATGACCCCGAGA
|
3810159ACGTTGGATGTTGCGATCACTTTCTCCAAGACGTTGGATGCTGAGTGAGGAAACCTCAGG
|
281438ACGTTGGATGACCTGAGGTTTCCTCACTCAGACGTTGGATGAGAGGTTTCTGTGACACCCG
|
3093029ACGTTGGATGGGCAGCTCTGATTGGATGTTACGTTGGATGCTCCACAGTTGTTTGGCCTC
|
2735442ACGTTGGATGATGCTTTTGACTCCGCTTCCACGTTGGATGATGTTCTGGTAGTCACCCAG
|
2569693ACGTTGGATGCTTGTTCTCGCGTGGATGTCACGTTGGATGTACTCAGCGTGTGTGAGCTC
|
281439ACGTTGGATGGCGGAGCCATACCTCTAAGCACGTTGGATGTCGCTGGCACTTTCGTCCC
|
281440ACGTTGGATGCTGGCTGAGATGCCATGATAACGTTGGATGATGGTGGGAGGAGCTAAATG
|
2569694ACGTTGGATGCGCCCCCTCCTTGGAAACCACGTTGGATGGCGCGGCGGGTGGGGTGTG
|
11575073ACGTTGGATGGCTCTTCGGCCTCTCAGGTACGTTGGATGAGGCCGTTTCTCAGGTCCAG
|
2569695ACGTTGGATGAGTCCCTGGACCTGAGAAACACGTTGGATGAGAAGACTCAGGCTCGAGGT
|
2075741ACGTTGGATGAAGATGCCAGTCCGTGGACCACGTTGGATGAGTGTCTCTCCTGTCCGCTC
|
11575074ACGTTGGATGTACCTCCTTACGCTGTGCTGACGTTGGATGAGTTGGAGAGATGGAGTCTT
|
2569696ACGTTGGATGAACTACCCTGACTCAGAGGCACGTTGGATGCTGGGCTCATGGAAGGAACC
|
2735439ACGTTGGATGTTCCTTCCATGAGCCCAGCCACGTTGGATGGGTCAAGGATCAGGAAGGAC
|
2569697ACGTTGGATGTGTCTCTGGGACGTGGTAGCACGTTGGATGTTTCCTCTCCTCTACGCCCT
|
2075742ACGTTGGATGAGCCAGGGAAAGAACCCAGGACGTTGGATGTTTAGACTCTGGGAGTGCGC
|
2569698ACGTTGGATGTTTAAACCGGAGGCCTGGGCACGTTGGATGTCAAGGGTTCTCAGAGGGCG
|
11669397ACGTTGGATGGGCTGAATTGCAGCACCAACACGTTGGATGAACCAACGCAAACCCCTCTG
|
901886ACGTTGGATGATCAGCTCTACGCGATCTGGACGTTGGATGTTCAGGCCCCACCTTCTGTTC
|
885742ACGTTGGATGCCTAAGCACTTGACATGCACACGTTGGATGATGCTGACCCCGACTTCAAC
|
2569699ACGTTGGATGAATGCTGACCCCGACTTCAAACGTTGGATGGCACTTGACATGCACTATCT
|
11549918ACGTTGGATGTTTTCGCCCCCCAGGGTGACACGTTGGATGACAGCCACAGCTAGCGCAGA
|
2569700ACGTTGGATGGGGACCTCAGTACCGGAACAACGTTGGATGCTCCCCAGCGATTACGTCTC
|
2228615ACGTTGGATGGGGCAGATGGTGACAGTAACACGTTGGATGTGGAACTCCCTCCAGTGTGA
|
ICAM-AAACGTTGGATGACCTTCTGGTGACTTCCAAGACGTTGGATGAGACGTAAGAAATGGCTCCG
|
2569701ACGTTGGATGCCAGACCTTGAACCAGATAGACGTTGGATGTCAAGGACGTAACGCTAACG
|
2569702ACGTTGGATGACCCTCCAGACCTTGAACCAACGTTGGATGACGTAACGCTAACGGTGGAG
|
2735440ACGTTGGATGTAGTCGAGCCATGCACTCTGACGTTGGATGGGCAGTCCAGAGTGTTTAAG
|
2569703ACGTTGGATGTCAGGAAGCTCCCAGACAGAACGTTGGATGATAACCCTTGGACGCCGATC
|
10418913ACGTTGGATGCCAAAGCCAACAATACACTCACGTTGGATGCAGCCAAGTAATGCGTTCTG
|
1056536ACGTTGGATGATTCTGGGAGCTCTGGGACTACGTTGGATGAGCCAAGCGTGAAGTGCGTG
|
2569704ACGTTGGATGGATTCATCCATCTCCGGTGGACGTTGGATGTCCAGGCACTCCCTGACATC
|
11673661ACGTTGGATGAAGCGATTCTCCTGCCTCAGACGTTGGATGTGGCGAAAACCCGTCTCTAC
|
10402760ACGTTGGATGAAGAGGATCCTGCCTCCTATACGTTGGATGGAAGGGCGAGGAATTTTAGC
|
ACGTTGGATGTGCGCCCAGGAGGAAACTTCACGTTGGATGCAGCTGATCTGGGCTGGAG
|
2569706ACGTTGGATGCTGTTGTTGCTCGACAGGCCACGTTGGATGTGGCCTCCAGCCCAGATCA
|
2569707ACGTTGGATGTGAGCGTGGCAGGCGCCATGACGTTGGATGGCGTGGCGCCCGTGCGCGT
|
2436545ACGTTGGATGGGCGCATCACGGTGCGCGTACGTTGGATGAAGACCCAGGTCACGCCCCC
|
2436546ACGTTGGATGTCTCAGATACCTCGCCCCGCACGTTGGATGCGCATCACGGTGCGCGTGG
|
2916060ACGTTGGATGGGCGAGGTATCTGAGAGGGACGTTGGATGTACTCTGTCCCACTTCCGTC
|
2916059ACGTTGGATGGGGCGAGGTATCTGAGAGGACGTTGGATGCTTTGACTTCTACTCTGTCC
|
2916058ACGTTGGATGTCAAAGTGCGATCAACAGCCACGTTGGATGCTCTCGGTCCCGGTAGACT
|
2569708ACGTTGGATGCGGTAGACTAGACGGAAGTGACGTTGGATGAAAGTGCGATCAACAGCCCC
|
735747ACGTTGGATGATCTTCCCCACAGTGGATTGACGTTGGATGACTGCTGCAGGAAAGGACTT
|
885743ACGTTGGATGTGAGAGAAGGCGATCTTGACACGTTGGATGCCAATTCACAATCCACTGTG
|
710845ACGTTGGATGAGGCCGAGAGCTCAGGCGAGACGTTGGATGTCGGGTCCGCCCTCCGCGCCT
|
2569709ACGTTGGATGTATTCAACTCCAAGGGCGTCACGTTGGATGAGAAACAGAAGCGGAGACAG
|
2569710ACGTTGGATGACCCCCATTTTCTACCCATCACGTTGGATGTTGCAGAAACAGAAGCGGAG
|
2569711ACGTTGGATGTGTCTCCGCTTCTGTTTCTGACGTTGGATGTGAATAACTCGGGAGGTCAC
|
2569712ACGTTGGATGACCCCAGGCCCTCTCAAAAAACGTTGGATGTCTGCAAGGTGGAACAAGCC
|
12610026ACGTTGGATGCGGTGGCTCATGCGTGTAATACGTTGGATGCTCCCGAATAGCTGGGACTA
|
4804129ACGTTGGATGTAACACGGTGAAACCCCGTCACGTTGGATGTGAGTAGCTGGGACTACAGG
|
12150978ACGTTGGATGAGACAGCAAGACTCCGTCTCACGTTGGATGCCCGCCTTAGTTTCCCAAAG
|
439843ACGTTGGATGTGGCTAACATGGTGAAACCCACGTTGGATGTTGAGTAGCTGGGACTACAG
|
892188ACGTTGGATGGTTTGTTTTTAGAGACAGGGACGTTGGATGGTCAAAGCCACTTCCAGCTA
|
2291473ACGTTGGATGAAGAGGCTATGTGGCAGATGACGTTGGATGAGGGTGAAGCTGGGTTTAAC
|
281416ACGTTGGATGTAACGTAGAGCACAGGTGAGACGTTGGATGCAACGCAAACACCAGTGTGG
|
281417ACGTTGGATGAAGAGACAGTGGAGAGGCTGACGTTGGATGAGAGCCATCGGGTCCCAGCAA
|
882589ACGTTGGATGTCGATAACCCCAGCAAAGAGACGTTGGATGTAAGGCCAAACCCCATTCCC
|
1048941ACGTTGGATGAGATTGTGCTGACACCGGAGACGTTGGATGCCACGTAGAAGTTCCTGGTG
|
281418ACGTTGGATGTGCGCTCAGTCAGCTTCCTCACGTTGGATGAGTGTTAGCCGAGGGCAAGC
|
430092ACGTTGGATGGTTGGGATTACAGGCATGAGACGTTGGATGATCTGTTGCCTGTCAAGATG
|
368835ACGTTGGATGGGTGGGAAAAAGACGTGAAGACGTTGGATGAGAGGGAATTAAGGAGGTCC
|
2358583ACGTTGGATGAAGACGTGAAGAGACACACCACGTTGGATGAGAGGGAATTAAGGAGGTCC
|
378395ACGTTGGATGACTTGGCCCCCTGCACTCACAACGTTGGATGACCGTGTTTTCCAGGCTCGCG
|
395782ACGTTGGATGATGCATGTCATGGCCGCCTCACGTTGGATGTTCCACCAGGTGCCCCTGGCA
|
1045384ACGTTGGATGTTCAACAAGCGAGTGACAGCACGTTGGATGGTGCAGAGATGGGCTTTCTC
|
281427ACGTTGGATGGACAATTGTAGTACCCAGCCACGTTGGATGAGGAGAATCGCTTGAACCTG
|
3745264ACGTTGGATGCAAAGTGCTAGGATCACAGGACGTTGGATGACTGCCCCATAGAGTGGCAA
|
281426ACGTTGGATGATCCTCACACCTCAGTCTCCACGTTGGATGAATGAGACTCCGTCTCTACC
|
281425ACGTTGGATGCCAGCGGCCCAGCTCACTCACGTTGGATGTCTGAGGCCAGAGCCTCGGA
|
281424ACGTTGGATGACCTGTGTTTCTAGGTGTGCACGTTGGATGCATGCCTGGGAAAAAACTCC
|
281423ACGTTGGATGAACCTCAAGCTGCTTCACTGACGTTGGATGGAGGAGCCCACCTTTAATGT
|
281422ACGTTGGATGAGAAATCCTCCTACCTTGGCACGTTGGATGGCCCGGCCTCTACATAAAAT
|
281420ACGTTGGATGCCAGGACTGTCTCTCTGTTTACGTTGGATGATGACACTACAGCCTGAGCA
|
3745263ACGTTGGATGTACATGAAGAAGGACTCGGCACGTTGGATGATCCGTCCAGTGCACGTAGA
|
3745262ACGTTGGATGGCAGCCGAGTCCTTCTTCATACGTTGGATGTTCCTGGTCTACAGTGAGCG
|
3745261ACGTTGGATGACACACAGCAGGGCATCCGTACGTTGGATGCGCAATCAATGCTTTCCACC
|
3181049ACGTTGGATGATCTTCAGGGATGGTCACTCACGTTGGATGGACAAATACAAAGGGACAGG
|
281412ACGTTGGATGTGACCTCAGGTGATTCACCCACGTTGGATGGGTATACCTTTAGCTGGCTG
|
3181048ACGTTGGATGCTTTTCTCCACCCACTCTACACGTTGGATGTAAACGCGTGATATGGAGGG
|
2230399ACGTTGGATGAGCGGCAGTTACCATGTTAGACGTTGGATGTTCTTCCCCCATTGCTTCTG
|
2278442ACGTTGGATGGGTGATGGACATTGAGGGTGACGTTGGATGTCCCTTCTGTCTCCAACCC
|
3181047ACGTTGGATGGAATGCGACAGTCATGAACCACGTTGGATGCCCCTAGGGTCACGTTGCA
|
3181046ACGTTGGATGTATCTTGCTGACTGGGTCACACGTTGGATGCGTGGGATCTTTGAAGAAGG
|
2304237ACGTTGGATGTGGGCCAGAACTTCACCCTGACGTTGGATGAAGCAGCACCACCGTGAGG
|
281413ACGTTGGATGTCAAAGCTCACAGTTCTCGGACGTTGGATGACTTAGCGGGTCCTGCAAAC
|
1058154ACGTTGGATGTCCCTTCCATCCTCATTTTTACGTTGGATGTGCAAGGCGCTAAACAAAAC
|
3176769ACGTTGGATGTTCCTGTTTATGGCCAGACGACGTTGGATGGTCTGAACCTGATTGGAGAG
|
2304238ACGTTGGATGCCTGGACATTTGTGTGTGAGACGTTGGATGCATGAGATTGAGATGCGTC
|
2304239ACGTTGGATGCAGGCTCCTCTAACATCACCACGTTGGATGACACCACTACCCAAGACCAG
|
2304240ACGTTGGATGAATCTCAGCAACGTGACTGGACGTTGGATGACACGGTGATGTTAGAGGAG
|
3176768ACGTTGGATGGAGAGGTGTTAAATGGTGGGACGTTGGATGGGAACATGAAGAAGTCCTGG
|
3176767ACGTTGGATGCGGTCTCTGATGGATTCTACACGTTGGATGAACAGGCCCCACCATTTAAC
|
3176766ACGTTGGATGTTTCGGGCTGCAATGGTCCCACGTTGGATGTAACACCTCTCTCCTTGTGC
|
281414ACGTTGGATGAAGGCACCTTCCTCTGTCAGACGTTGGATGTGGGCCACAACACGGATGGTA
|
281415ACGTTGGATGGCACAAAGAGCTAAGGTAGGACGTTGGATGGAATCCTGGATAGACAGTGG
|
TABLE 11
|
|
|
dbSNP rs#
Extend Primer
Term Mix
|
|
|
2884487
AGAGACAGGGTCTCGCC
ACT
|
|
2358580
TCATCCAGCGGCGCCTCGC
ACT
|
|
2304236
GCCCTGGGTAGCGTGGGG
ACT
|
|
1059840
GCTCAGAAGAGGTGCTTCAC
CGT
|
|
1059843
CTGTTGATGTGAAGCACCTCTT
ACG
|
|
11115
AAGGGTGGGCGTGGGCCT
ACT
|
|
1059849
CAGAAGCCCGTCTGGGCT
ACG
|
|
1059855
AAAAAGAGGGAATGGATGCA
ACT
|
|
5030386
CCTGGGCTCAAGTGATCCT
ACT
|
|
5030339
GCTGGGATTACAGGTGGGA
ACT
|
|
5030387
TTGTGGCTGCAAGTGGGAC
ACT
|
|
5030388
CGCGCCCCACAACAGGAAA
ACT
|
|
1799766
GCGGAGCCTGGGACGCC
CGT
|
|
5030389
GCGCCGAGCCCCTCCGC
ACT
|
|
5490
CTACTCAGAGTTGCAACCTC
CGT
|
|
11575070
CCTGCCTCAGCCTCCCGA
ACT
|
|
5030340
GCGTCTCTTACAGTTTCTCAG
ACG
|
|
5030390
CCAAAGCTGAGAAGTGGGAC
ACT
|
|
5030391
GGGGAACCAGGAGGGTGG
ACT
|
|
3093035
TTCTGTCTCAAAAAACAAAGC
ACT
|
|
11667983
CCTTCGGAGGCAGCAGAAT
ACG
|
|
5030341
TTTTTGAGACGGAGTCTCACT
ACT
|
|
5030342
GACGGAGTCTCACTCTGTC
ACT
|
|
5030343
GCTACTCAGGGAGGCTGAG
ACT
|
|
5030344
CTCCTCACTCCCTGAGACA
ACG
|
|
5030347
CTGCCTCCCGGGTTCAAGT
ACT
|
|
5030348
CACTTGAACCCGGGAGGCA
ACT
|
|
5030349
CAGACTGGAGTGCAGTGGC
ACT
|
|
5030350
TGCTAAAGATGTGTTCTTTTATTT
CGT
|
|
5030351
GAAGAAACGAGGGAAGAGGC
ACT
|
|
5491
CCTCCTGTGACCAGCCCA
CGT
|
|
5030352
CTGCACGTCTCTCCCACC
ACT
|
|
5030353
GGTGGGAGAGACGTGCAG
ACT
|
|
10420063
CGCCCGGCCATCAATTCTTT
ACG
|
|
11879117
CCCTCAGCCTCCCAAAGTG
ACT
|
|
5030354
TGTCATTTCTCCCACTTCCTT
ACT
|
|
5030355
CAGGAGGTGAAGGTTGCGG
ACT
|
|
281428
GCGCCCAGCACCACGCC
ACG
|
|
5030358
CAGGAGATCAAGACCAGCC
ACG
|
|
5030359
AGCCACTGCCCCCAGCC
ACT
|
|
5030392
GTCCCCAAAGTAGGAAGGAC
ACT
|
|
5030393
AGGTGGGAGGATCACCTGA
ACT
|
|
5030360
CTCCAGCCTGGGTGACAGA
ACT
|
|
5030394
CAGGTGAGGGAAGTCCCC
ACT
|
|
281429
GACTGTGTGTCAAAAAAAA
ACT
|
|
5030361
TATCAGGCAGAGCCGCGC
ACT
|
|
5030362
AGAGGGAGAAATGTGGCAGA
ACT
|
|
281430
GAGCCACTGCACCTGGCC
ACG
|
|
281431
ACAGGTGTGAGCCACTGC
ACT
|
|
5030395
GGCTCAAGTGGGAGGATCA
ACG
|
|
5827095
CCATCAATCAATTTTTTTTTTTTTTT
CGT
|
|
281432
CTAATCCCTGGCCTGCTCA
ACT
|
|
5030364
GGACCATAGCCAACTGCTC
CGT
|
|
5030365
GGTCAGAGTTTTCTTGACTATAT
ACT
|
|
5030368
GAGACCAGCCTGACCAACA
ACG
|
|
5030369
TCATCTGAGGTTGGGAGTTC
ACT
|
|
3073809
CGGCCTTTTTTTTTTTTTTTTTTTTT
ACT
|
|
2358581
CTTGCAGTGAGCCCAGATCG
CGT
|
|
7258215
CGTGTTAGCCAGGATGGTCT
ACG
|
|
5030371
AGCCTVGCTTTCTTGAGATAC
ACT
|
|
5030372
GGTTTCTTTTTTAGAGTGATTGA
ACT
|
|
281433
GTACATAAGCAGGAGGTTTCTT
ACT
|
|
5030374
CTCTGTCTACCTCTTAAGTGA
CGT
|
|
5030375
GTTCAGGAAACTGAGGTTCAG
ACT
|
|
5030397
CAAATGCAGGACCCCCCC
ACT
|
|
281434
TCAAGACCAGCCTGGCCAA
ACG
|
|
12462944
ATATTGGCCAGGCTGGTCTT
ACT
|
|
5030398
CAGGGTCTTTCTTTCCCAGG
ACT
|
|
5030378
CCTGGCCTCAAGTGACCCT
ACT
|
|
12459133
CTGGCCAACAGGTTTTTTTTTTT
ACT
|
|
5030399
CCCCCACCTCTGTTTTCCT
ACT
|
|
5492
CTGGCTCCCGTTTCAGCTC
ACT
|
|
1800019
CGTCCAGGGAACAGACCAC
ACT
|
|
1799969
CCGAGACTGGGAACAGCC
ACG
|
|
5493
GGTCTGTTCCCTGGACGG
ACT
|
|
5030381
AGGCCTCAGTCAGTGTGAC
ACG
|
|
5494
TCAGTGTGACCGCAGAGGA
ACG
|
|
3093033
GGGTTCAGGTCACACCC
ACG
|
|
5495
CTCTGGCTTCGTCAGAATCA
ACG
|
|
1801714
CCAGCCCAGCCACTGGGCC
ACG
|
|
2071441
CGGCCAGCTTATACACAAGAA
ACG
|
|
5496
CACCTCCATGTCATCTCATC
ACT
|
|
5497
GTTTTTCCAGATGGCCCCC
ACT
|
|
5030382
CAGAGCACATTCACGGTCACCT
ACG
|
|
5030400
TCCTCCCCACAGCCCCC
ACG
|
|
2071440
GAGGAAGAGGCCCTGTCC
ACG
|
|
5499
GCCATGCAGCTACACCTAC
ACG
|
|
3093032
CTTCTGTAAGTCTGTGGG
ACT
|
|
105798
TTACCTGGTGACCTTGAATGTGAT
ACG
|
|
5500
GAGTGCCTGGCAAAAAGATCA
ACT
|
|
5501
CCATATAGTGCTTTTGTGCCG
ACT
|
|
5030383
ACTCATGTCCAGACATGACC
ACT
|
|
281436
ACTGCAGTCTTGACCTTTTG
ACT
|
|
923366
TGCGAGACCCCGTCTCTG
ACT
|
|
281437
TTTTTTTTCCAGAGACGGGGTCT
ACG
|
|
3093030
CCAGAACCTCAGGGTATG
ACT
|
|
5030384
ATCACCGCCTACAGTGAGG
ACT
|
|
5030385
AGGGAGGTCTGTCGACCC
ACT
|
|
3810159
CCAAGTTCCTTGTCTCCCT
ACT
|
|
281438
CGAAGCCCCAGACTCTGTGTA
ACT
|
|
3093029
AGTTTCCTATCCCAGCC
ACT
|
|
2735442
GCTTTGACACCCCCCACC
ACT
|
|
2569693
CGCGTGGATGTCAGGGCC
ACG
|
|
281439
ACCCCTCCGGGTCAGCTCC
ACT
|
|
281440
TAATAAGCTGGACTCCGAGC
ACG
|
|
2569694
ATCCCCAAGCGCAACTCTG
ACG
|
|
11575073
CGGCCTCTCAGGTAAGAGC
ACG
|
|
2569695
CTCTGCCCTCGCCTCGCT
ACT
|
|
2075741
GTGGACCATGGTGCACAGCA
ACT
|
|
11575074
CTGTGCACCATGGTCCACG
ACT
|
|
2569696
TGTTCCCGCTCCACCCAGA
ACT
|
|
2735439
CAGCCTTGCGTCCCGGC
ACT
|
|
2569697
GGGACGTGGTAGCAGAGAG
ACT
|
|
2075742
AACCCAGGCGTCCCGCGTC
ACT
|
|
2569698
TGGGTTCTTTCCCTGGCTG
ACT
|
|
11669397
TTGCAGCACCAACTGCCCT
ACG
|
|
901886
AGAGTCCGCAGCTCTTTGAAC
ACT
|
|
885742
TGCACTATCTTATCGTATTATCA
ACG
|
|
2569699
CCCTCCGTGCCTTGAGGA
ACT
|
|
11549918
CCCAGGGTGACGTTGCAGA
ACG
|
|
2569700
TCAGTACCGGAACAGGCGTG
ACT
|
|
2228615
AGTAACCTGCGCAGCTGGG
ACT
|
|
ICAM-AA
TCCAAGGACCCGCCTGCT
ACG
|
|
2569701
CTTGAACCAGATAGAAATGCAC
ACG
|
|
2569702
CAGACCTTGAACCAGATAGAA
ACT
|
|
2735440
ACCAGTGGCGCCTTTTTCG
ACG
|
|
2569703
CTCCCAGACAGAGTGCATG
ACT
|
|
10418913
GCACCAGCGCTGGACAGC
ACT
|
|
1056536
GCAGCAGCACCCCCTCAGTGG
ACG
|
|
2569704
CTCCGGTGGCGCTGCAAA
ACT
|
|
11673661
GGACCACAGGCGCCCAC
ACT
|
|
10402760
CTCCTTCCCCGACAATCAG
ACT
|
|
CACGTTGACCTGCCGCGC
ACT
|
|
2569706
GGCCGATGTTGAGGGCCC
ACG
|
|
2569707
GGCGAGTACGAGTGCGCA
ACT
|
|
2436545
ACGGTGCGCGTGGCCGGT
CGT
|
|
2436546
CCTCTCCCCAGCTGCCAC
ACT
|
|
2916060
CTCCCTCTCGGTCCCGG
ACT
|
|
2916059
CGGTCCCGGTAGACTAG
ACT
|
|
2916058
TTCTACTCTGTCCCACT
CGT
|
|
2569708
CTAGACGGAAGTGGGACAGA
ACT
|
|
735747
TGTGAATTGGGTCAAGTTTCC
ACT
|
|
885743
GACCCCTCTCTCCCTCCA
CGT
|
|
710845
AGGCGAGGCCGTGTGTCT
ACT
|
|
2569709
GGCGTCACCCCCATTTTCTA
ACT
|
|
2569710
TTTCTACCCATCCCCTCAATA
ACT
|
|
2569711
GTTTCTGCAAGGTGGAACAAG
ACT
|
|
2569712
GGCCCTCTCAAAAATCGCTT
CGT
|
|
12610026
AGCTGGGCATGGTGGTGC
ACT
|
|
4804129
AAACCCCGTCTCTACTAAAAAT
CGT
|
|
12150978
GCCAGGGCCGAGCACAGT
ACT
|
|
439843
ATGGTGAAACCCCGTCACTA
CGT
|
|
892188
TGGGCTGGAGCACAATGAC
ACT
|
|
2291473
GGAGTGTCCCTGGACCCC
ACT
|
|
281416
GGTCCACACCGACGCCAG
ACT
|
|
281417
CCCCTGCCCAGGACACCCC
ACT
|
|
882589
CCCCAGCAAAGAGAGGTCAT
ACT
|
|
1048941
GGAAGGAGCGGAATTCACCCT
ACT
|
|
281418
TCAGCTTCCTCCCTCCCC
ACT
|
|
430092
ATTACAGGCATGAGCCACTG
ACG
|
|
368835
AGACGTGAAGAGACACACCT
ACT
|
|
2358583
AAGAGACACACCTAATTTGTGG
ACT
|
|
378395
GCCCGCGTCCTCCTCTCC
CGT
|
|
395782
GCGTGAGTGCCAGGGTTCT
ACT
|
|
1045384
ACAATGTCCGACTCCCACA
ACT
|
|
281427
CTTTGTATACAATCTTCCCTC
ACG
|
|
3745264
ATACCATGCCAGGCATT
ACT
|
|
281426
GAGCTGGGACCACAGGCA
ACG
|
|
281425
CCAGCTCACTCCTCCCCC
CGT
|
|
281424
TAGGTGTGCGTGTGTGTGTG
ACG
|
|
281423
GCCCACCCTCCATTCAGC
ACG
|
|
281422
CTGGGGAACTACAGGAATGC
ACT
|
|
281420
ACTGTCTCTCTGTTTTTGAGAT
ACT
|
|
3745263
TCGGCTGCCCGTGCCAAGTC
ACT
|
|
3745262
GAGTCCTTCTTCATGTACTC
ACT
|
|
3745261
GCAGCTGCACCGACAGTTC
ACT
|
|
3181049
ACTCCCTGCCCTGGCCC
ACT
|
|
281412
GCTGGGATTATAAGCGTG
ACT
|
|
3181048
TACCACAGGGTGGCGGG
ACT
|
|
2230399
GTTACCATGTTAGGGAGGAGA
ACT
|
|
2278442
GGACATTGAGGGTGAGCTAA
ACG
|
|
3181047
CAGGAGGGTGCCCGGGA
ACT
|
|
3181046
ACTGGGTCACCCTTCTTC
ACT
|
|
2304237
TGCGCTGCCAAGTGGAGG
ACT
|
|
281413
GCTCACAGTTCTCGGCAGGAC
ACG
|
|
1058154
CTTCCATCCTCATTTTTTTTTATT
ACT
|
|
3176769
CGGGGTGGGTGGATCAA
ACT
|
|
2304238
CATTTGTGTGTGAGATACAAAGA
ACG
|
|
2304239
ATCACCGTGTACAGTGAGTC
ACT
|
|
2304240
GCTCAGTGTACTGCAATGGCTC
ACG
|
|
3176768
TGTTGATGCGTGGGTTGGGG
ACT
|
|
3176767
TGGATTCTACCTTTCCC
CGT
|
|
3176766
TCCTTCTGAGTTCTCCC
ACG
|
|
281414
CCTTCCTCTGTCAGAATGGC
ACG
|
|
281415
GGTGATTTGGGGACAGCTGA
ACT
|
|
Genetic Analysis of Allelotyping Results
Allelotyping results are shown for cases and controls in Table 12. The allele frequency for the A2 allele is noted in the fifth and sixth columns for breast cancer pools and control pools, respectively, where “AF” is allele frequency. SNPs with blank allele frequencies were untyped.
TABLE 12
|
|
Breast
Position inCancer
SEQ IDChromosomeA1/A2Associated
dbSNP rs#NO: 1PositionAlleleCase AFControl AFp-ValueORAllele
|
|
2884487 23010219830T/CT = 0.788T = 0.760.3070.85T
C = 0.212C = 0.240
2358580 428210223882A/GA =A = 0.474
G =G = 0.526
23042361184410231444A/CA = 0.986A = 0.9950.3352.92C
C = 0.014C = 0.005
10598401189010231490A/TA = 0.19A = 0.2030.6021.09T
T = 0.810T = 0.797
10598431190510231505C/TC = 0.999C = 0.9990.961.26T
T = 0.001T = 0.001
111151194210231542T/CT = 0.566T = 0.6340.04011.33C
C = 0.434C = 0.366
10598491205410231654G/AG = 0.754G = 0.8040.06491.34A
A = 0.246A = 0.196
10598551207010231670T/CT = 0.001T = 0.0030.8383.25C
C = 0.999C = 0.997
50303862149710241097C/GC = 0.999C = 0.9990.9871.12G
G = 0.001G = 0.001
50303392153710241137A/GA = 0.002A = 0.0020.9930.93A
G = 0.998G = 0.998
50303872168210241282T/GT = 0.999T = 0.9950.7060.27T
G = 0.001G = 0.005
50303882207310241673A/GA = 0.001A = 0.0010.9683.66G
G = 0.999G = 0.999
17997662239310241993C/—C = 0.001C = 0.0020.9521.46—
— = 0.999— = 0.998
50303892239410241994A/—A = 0.983A = 0.9790.7570.80A
— = 0.017— = 0.021
54902322710242827C/AC = 0.001C = 0.00111.00
A = 0.999A = 0.999
115750702361410243214C/GC = 0.001C = 0.0010.9861.58G
G = 0.999G = 0.999
50303402368110243281C/TC = 0.963C = 0.9670.8291.13T
T = 0.037T = 0.033
50303902393710243537A/GA = 0.191A = 0.1450.07480.72A
G = 0.809G = 0.855
50303912403710243637A/GA = 0.012A = 0.0440.03733.95G
G = 0.988G = 0.956
30930352437310243973A/GA = 0.113A = 0.0850.2230.73A
G = 0.887G = 0.915
116679832458910244189C/TC = 1.000C = 0.9980.840.36C
T = 0.000T = 0.002
503034124675-10244275{circumflex over ( )}CT/—CT = 0.691CT = 0.7450.07461.30—
2467610244276— = 0.309— = 0.255
50303422468010244280T/GT = 0.373T = 0.3890.6341.07G
G = 0.627G = 0.611
50303432475410244354T/CT = 0.674T =
C = 0.326C =
50303442505310244653G/AG = 1.000G = 1.0000.9520.35G
A = 0.000A = 0.000
50303472600410245604A/CA = 0A = 01
C = 1.000C = 1.000
50303482602310245623A/GA = 0.076A = 0.0720.8430.95A
G = 0.924G = 0.928
50303492604610245646T/CT = 0.832T = 0.8190.6180.92T
C = 0.168C = 0.181
50303502610010245700A/TA = 1.000A = 1.0001
T = 0T = 0
50303512681710246417T/CT = 0.002T = 0.0020.9981.02C
C = 0.998C = 0.998
54912694010246540T/AT = 0.001T = 0.0020.8533.82A
A = 0.999A = 0.998
50303522714310246743G/CG = 0.631G = 0.620.7320.96G
C = 0.369C = 0.380
50303532716210246762A/GA = 0.002A = 0.0040.8582.12G
G = 0.998G = 0.996
104200632832810247928G/AG = 0.001G = 0.0020.8646.56A
A = 0.999A = 0.998
118791172879910248399G/CG = 0.998G = 1.0000.8443.03C
C = 0.002C = 0.000
50303542916610248766A/CA = 0.999A = 1.0000.9891.15C
C = 0.001C = 0.000
50303552933110248931A/CA = 0.999A = 0.9990.9851.12C
C = 0.001C = 0.001
2814282972410249324C/TC = 0.821C = 0.8230.9511.01T
T = 0.179T = 0.177
50303582977310249373G/AG = 0.006G = 0.0070.9661.12A
A = 0.994A = 0.993
50303592986210249462A/GA = 0.001A = 0.0030.8584.75G
G = 0.999G = 0.997
50303922987710249477T/CT = 0.002T = 0.0010.9580.59T
C = 0.998C = 0.999
50303933019410249794T/GT = 0T = 0.0050.836G
G = 1.000G = 0.995
50303603025810249858T/GT = 0T = 0.0010.972G
G = 1.000G = 0.999
50303943054910250149A/GA = 0.005A = 0.0060.9261.23G
G = 0.995G = 0.994
2814293064810250248T/CT = 0.999T = 1.0000.9382.63C
C = 0.001C = 0.000
50303613090910250509T/CT = 0.002T = 0.0020.9891.10C
C = 0.998C = 0.998
50303623096210250562A/CA = 0.004A = 0.0020.7910.29A
C = 0.996C = 0.998
2814303133710250937G/AG = 0.015G = 0.0080.4980.51G
A = 0.985A = 0.992
2814313134510250945T/CT =T = 0.886T
C =C = 0.114
50303953153410251134C/TC = 0.998C = 0.9980.9731.11T
T = 0.002T = 0.002
58270953194210251542A/—A = 0.532A = 0.5320.9861.00A
— = 0.468— = 0.468
2814323205810251658G/CG = 0.51G = 0.5530.1941.19C
C = 0.490C = 0.447
50303643210910251709A/TA = 0.001A = 0.0020.9024.40T
T = 0.999T = 0.998
50303653240110252001A/GA = 1.000A = 1.00011.03
G = 0.000G = 0.000
50303683284510252445G/AG = 0.099G = 0.0970.9010.97G
A = 0.901A = 0.903
50303693286410252464T/CT = 0.506T = 0.4870.5410.92T
C = 0.494C = 0.513
307380932965-10252565{circumflex over ( )}TT/—T = 0.848T = 0.8590.691.10—
3296610252566— = 0.152— = 0.141
23585813301110252611G/TG = 0.904G = 0.9190.5251.20T
T = 0.096T = 0.081
72582153317010252770C/TC = 0.85C = 0.8470.880.97C
T = 0.150T = 0.153
50303713351610253116A/GA = 0.001A = 0.0010.9690.58A
G = 0.999G = 0.999
50303723360810253208T/CT = 1.000T = 1.0000.9971.08C
C = 0.000C = 0.000
2814333362310253223A/CA = 1.000A = 1.0000.9891.34C
C = 0.000C = 0.000
50303743367210253272C/AC = 0.156C =A
A = 0.844A =
50303753372410253324A/—A = 0.999A = 1.0000.942.17—
— = 0.001— = 0.000
50303973378710253387T/GT = 0.231T = 0.180.06970.73T
G = 0.769G = 0.820
2814343402010253620G/AG = 0.932G = 0.930.9020.97G
A = 0.068A = 0.070
124629443403810253638C/GC = 0.004C = 0.0060.8881.32G
G = 0.996G = 0.994
50303983419010253790C/GC = 0.959C = 0.9930.0645.64G
G = 0.041G = 0.007
50303783470610254306C/GC = 0.993C = 0.9950.9181.25G
G = 0.007G = 0.005
124591333477810254378T/GT = 0.376T = 0.3470.3650.88T
G = 0.624G = 0.653
50303993555310255153A/GA = 0.002A = 0.0010.9220.23A
G = 0.998G = 0.999
54923569010255290G/CG = 1.000G = 1.0000.9930.00G
C = 0C = 0.000
18000193617310255773A/CA = 0.002A = 0.0010.9140.47A
C = 0.998C = 0.999
17999693619210255792G/AG = 0.882G = 0.8490.1340.75G
A = 0.118A = 0.151
54933619410255794T/GT = 0.001T = 00.990.00T
G = 0.999G = 1.000
50303813630810255908C/TC = 0.877C =
T = 0.123T =
54943631710255917C/TC = 0.999C = 1.0000.8735.90T
T = 0.001T = 0.000
30930333643110256031G/AG = 0.991G = 0.9690.1130.30G
A = 0.009A = 0.031
54953649610256096G/AG = 1.000G = 0.9990.8880.19G
A = 0.000A = 0.001
18017143660810256208C/TC = 0.995C = 0.980.1290.25C
T = 0.005T = 0.020
20714413670810256308C/TC = 1.000C = 1.0000.9931.25T
T = 0.000T = 0.000
54963684710256447A/GA = 0.003A = 0.0090.4694.06G
G = 0.997G = 0.991
54973686810256468A/GA = 0.004A = 0.0060.8131.61G
G = 0.996G = 0.994
50303823708310256683G/AG = 0.449G = 0.5120.04841.29A
A = 0.551A = 0.488
50304003719610256796C/TC = 1.000C = 0.9990.9690.76C
T = 0.000T = 0.001
20714403737310256973G/AG = 0.999G = 1.0000.8755.74A
A = 0.001A = 0.000
54993746510257065C/TC = 0.994C = 1.0000.478.13T
T = 0.006T = 0.000
30930323773610257336T/CT = 0.322T = 0.2670.06620.77T
C = 0.678C = 0.733
10579813795910257559G/AG = 0.032G = 0.0260.6930.80G
A = 0.968A = 0.974
55003803110257631A/GA = 0.995A = 0.9960.8681.35G
G = 0.005G = 0.004
55013809110257691T/CT = 1.000T = 0.9990.8620.06T
C = 0.000C = 0.001
50303833824310257843T/CT = 0.002T = 0.0010.9640.58T
C = 0.998C = 0.999
2814363853110258131A/GA = 0.501A = 0.4520.1320.82A
G = 0.499G = 0.548
9233663862310258223T/CT = 0.517T = 0.5620.1611.20C
C = 0.483C = 0.438
2814373863810258238C/TC = 0.804C = 0.8520.07931.39T
T = 0.196T = 0.148
30930303880310258403T/CT = 0.553T = 0.6060.1371.24C
C = 0.447C = 0.394
50303843948910259089A/GA = 0.001A = 0.0010.9880.80A
G = 0.999G = 0.999
50303854000810259608G/CG = 0.002G = 0.0020.9740.79G
C = 0.998C = 0.998
38101594071110260311T/CT = 0.001T = 0.0010.91568.31C
C = 0.999C = 0.999
2814384077510260375T/GT = 0.767T = 0.8020.311.23G
G = 0.233G = 0.198
30930294095110260551C/GC = 0.912C = 0.920.6831.11G
G = 0.088G = 0.080
27354424121810260818G/CG = 0.999G = 0.9990.970.79G
C = 0.001C = 0.001
25696934130410260904C/TC = 0.703C = 0.6410.04790.75C
T = 0.297T = 0.359
2814394151010261110G/CG = 0.471G = 0.4180.1110.81G
C = 0.529C = 0.582
2814404170410261304G/AG = 0.268G = 0.2550.6760.94G
A = 0.732A = 0.745
25696944202010261620C/TC = 0.999C = 0.9990.9721.20T
T = 0.001T = 0.001
115750734221010261810C/TC = 0.924C =T
T = 0.076T =
25696954230210261902C/GC = 1.000C = 0.9980.8150.02C
G = 0.000G = 0.002
20757414249810262098G/CG = 0.715G = 0.6310.01120.68G
C = 0.285C = 0.369
115750744252010262120A/GA = 0.088A = 0.0970.7021.11G
G = 0.912G = 0.903
25696964260710262207A/GA = 0.005A = 0.0040.9090.69A
G = 0.995G = 0.996
27354394267410262274T/GT = 1.000T = 1.0000.928G
G = 0.000G = 0
25696974292910262529G/CG = 1.000G = 1.0000.973.84C
C = 0.000C = 0.000
20757424300710262607G/CG =G = 0.638G
C =C = 0.362
25696984304010262640C/GC = 1.000C = 1.0000.98G
G = 0.000G = 0
116693974324610262846C/TC = 1.000C = 1.0000.9620.00C
T = 0T = 0.000
9018864353110263131T/CT = 0.667T = 0.6450.5440.90T
C = 0.333C = 0.355
8857424402310263623G/AG = 0.012G = 0.0160.6331.46A
A = 0.988A = 0.984
25696994402410263624T/GT = 0.999T = 1.0000.9621.82G
G = 0.001G = 0.000
115499184433810263938C/TC = 0.635C = 0.5620.02930.74C
T = 0.365T = 0.438
25697004449910264099T/GT = 0.006T = 0.0110.7031.80G
G = 0.994G = 0.989
22286154476810264368A/GA = 0.402A = 0.4840.03181.40G
G = 0.598G = 0.516
ICAM-AA4500310264603C/TC = 0.934C = 0.9580.3091.59T
T = 0.066T = 0.042
25697014534110264941G/AG = 1.000G = 1.0000.91710.14A
A = 0.000A = 0.000
25697024534710264947T/CT = 0.709T = 0.6460.06810.75T
C = 0.291C = 0.354
27354404557710265177G/AG = 0.01G = 0.0060.6240.52G
A = 0.990A = 0.994
25697034562710265227C/GC = 0.563C = 0.5270.2740.86C
G = 0.437G = 0.473
104189134579410265394A/GA = 0.001A = 0.0020.9232.09G
G = 0.999G = 0.998
10565364624410265844C/TC = 1.000C = 1.0000.9892.49T
T = 0.000T = 0.000
25697044646910266069T/CT = 0.003T = 0.0010.9050.24T
C = 0.997C = 0.999
116736614699910266599G/CG = 0.997G = 0.9990.8742.39C
C = 0.003C = 0.001
104027604726510266865T/CT = 0.168T = 0.1040.02760.58T
C = 0.832C = 0.896
ICAM-AB4750410267104A/GA = 0.264A =
G = 0.736G =
25697064754710267147G/AG = 0.997G = 1.0000.66645.64A
A = 0.003A = 0.000
25697074763710267237C/GC = 0.173C = 0.1710.9420.99C
G = 0.827G = 0.829
24365454769110267291C/AC = 0.001C = 0.0010.9910.86C
A = 0.999A = 0.999
24365464769210267292A/CA = 1.000A = 0.9980.8660.26A
C = 0.000C = 0.002
29160604778810267388A/CA = 0.99A = 0.9930.8031.39C
C = 0.010C = 0.007
29160594779610267396T/CT = 0.999T = 0.9990.9680.73T
C = 0.001C = 0.001
29160584780010267400T/AT = 1.000T = 0.9990.8690.30T
A = 0.000A = 0.001
25697084781210267412A/GA = 0.004A = 0.0030.9360.73A
G = 0.996G = 0.997
7357474796910267569T/CT = 0.999T = 1.0000.912.15C
C = 0.001C = 0.000
8857434803510267635A/TA = 0.661A = 0.6760.6981.07T
T = 0.339T = 0.324
7108454856910268169C/GC = 0.744C = 0.6650.01560.68C
G = 0.256G = 0.335
25697094882310268423C/GC = 0.999C = 1.0000.9671.45G
G = 0.001G = 0.000
25697104883810268438A/GA = 0.999A = 0.9980.9430.71A
G = 0.001G = 0.002
25697114889410268494C/GC = 1.000C = 1.0000.980.60C
G = 0.000G = 0.000
25697124893410268534A/TA = 1.000A = 1.0000.9831.93T
T = 0.000T = 0.000
126100264924910268849A/GA = 0.992A =G
G = 0.008G =
48041294950910269109C/AC = 0.002C = 0.0020.9780.83C
A = 0.998A = 0.998
121509784971810269318A/GA = 0.8A = 0.7820.5990.90A
G = 0.200G = 0.218
4398434996310269563C/AC = 1.000C = 0.9990.9810.82C
A = 0.000A = 0.001
8921885119310270793T/CT = 0.487T = 0.5670.01221.38C
C = 0.513C = 0.433
22914735718110276781T/CT = 0.913T = 0.9090.830.95T
C = 0.087C = 0.091
2814166018410279784A/GA = 0.456A = 0.4960.2211.18G
G = 0.544G = 0.504
2814176053010280130T/CT = 0.532T = 0.5260.860.98T
C = 0.468C = 0.474
8825896135410280954T/CT = 0T = 0.0020.865C
C = 1.000C = 0.998
10489416261610282216T/GT = 0.304T =
G = 0.696G =
2814186278510282385G/CG = 0.088G = 0.06800.3690.76G
C = 0.912C = 0.932
4300926635110285951C/TC = 0.764C = 0.7440.5880.90C
T = 0.236T = 0.256
3688356738610286986A/GA = 0.303A = 0.2740.3470.86A
G = 0.697G = 0.726
23585836739510286995T/GT = 0.696T = 0.6740.5050.90T
G = 0.304G = 0.326
3783956782210287422C/AC = 0.323C =A
A = 0.677A =
3957826802810287628T/CT = 0.726T = 0.6560.1150.72T
C = 0.274C = 0.344
10453846864610288246T/GT = 0.326T = 0.3020.4240.89T
G = 0.674G = 0.698
2814277052010290120C/TC = 0.785C = 0.8230.2261.27T
T = 0.215T = 0.177
37452647096610290566T/GT = 0.156T = 0.1640.761.06G
G = 0.844G = 0.836
2814267245110292051G/AG = 0.437G = 0.3210.0001960.61G
A = 0.563A = 0.679
2814257319910292799G/TG = 0.806G =
T = 0.194T =
2814247431910293919C/TC = 0.753C = 0.7480.8610.97C
T = 0.247T = 0.252
2814237689310296493C/TC = 0.804C = 0.8040.9931.00T
T = 0.196T = 0.196
2814227775510297355T/CT = 0.372T = 0.3640.8290.97T
C = 0.628C = 0.636
2814207935410298954A/GA = 0.608A = 0.5670.2130.85A
G = 0.392G = 0.433
37452638090110300501A/GA = 0.064A = 0.080.5131.27G
G = 0.936G = 0.920
37452628094010300540T/CT = 0.996T = 0.9990.7314.38C
C = 0.004C = 0.001
37452618111110300711T/CT = 0.987T = 0.9830.7520.76T
C = 0.013C = 0.017
31810498251710302117T/CT = 0.353T = 0.3630.7611.04C
C = 0.647C = 0.637
2814128287410302474T/CT = 0.846T = 0.8410.8230.96T
C = 0.154C = 0.159
31810488497810304578A/GA = 1.000A = 1.0000.980.46A
G = 0.000G = 0.000
22303998600310305603C/GC = 0.171C = 0.1610.7080.93C
G = 0.829G = 0.839
22784428622610305826G/AG = 0.42G = 0.4050.6740.94G
A = 0.580A = 0.595
31810478720610306806A/GA = 0.008A = 0.0030.6540.30A
G = 0.992G = 0.997
31810468753510307135T/CT = 0.999T = 1.0000.9462.38C
C = 0.001C = 0.000
23042378796810307568T/CT = 0.898T = 0.9070.7261.10C
C = 0.102C = 0.093
2814138813410307734G/AG = 0.697G = 0.7020.8771.03A
A = 0.303A = 0.298
10581548829710307897A/CA = 0.22A = 0.1860.310.81A
C = 0.780C = 0.814
31767698843410308034T/CT = 0.801T = 0.7860.5930.91T
C = 0.199C = 0.214
23042389060210310202G/AG = 0.002G = 0.0010.9540.62G
A = 0.998A = 0.999
23042399075010310350T/CT = 0.001T = 0.0030.8762.50C
C = 0.999C = 0.997
23042409079210310392G/AG = 0.828G = 0.7970.2610.82G
A = 0.172A = 0.203
31767689106510310665A/GA = 0.355A = 0.350.8710.98A
G = 0.645G = 0.650
31767679115110310751C/AC = 0.278C = 0.2770.9510.99C
A = 0.722A = 0.723
31767669117810310778C/TC = 0.768C = 0.7650.9370.99C
T = 0.232T = 0.235
2814149168510311285G/AG = 0.697G = 0.720.471.12A
A = 0.303A = 0.280
2814159239310311993T/GT = 0.341T = 0.3120.3430.88T
G = 0.659G = 0.688
|
FIG. 1A shows proximal SNPs in and around the ICAM region for females. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs FIG. 1A can be determined by consulting Table 12. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.
To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10−8 were truncated at that value.
Finally, the gene or genes present in the loci region of the proximal SNPs as annotated by Locus Link (http address: www.ncbi.nlm.nih.gov/LocusLink/) are provided on the graph. The exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.
Additional Genotyping
In addition to the ICAM region incident SNP, fourteen other SNPs were genotyped in the discovery cohort. The discovery cohort is described in Example 1. The SNP rs2228615 is located in the ICAM5 encoding portion of the sequence, and is associated with breast cancer with a p-value of 0. .00236, and encoded non-synonymous amino acids (see Table 15).
The methods used to verify and genotype the two proximal SNPs of Table 15 are the same methods described in Examples 1 and 2 herein. The PCR primers and extend primers used in these assays are provided in Table 13 and Table 14, respectively.
TABLE 13
|
|
dbSNP rs#Forward PCR primerReverse PCR primer
|
|
1801714ACGTTGGATGAGGGTTGCAGAGCAGGAGAAACGTTGGATGAGCCAAGGTGACGCTGAATG
|
2228615ACGTTGGATGAGATGGTGACAGTAACCTGCACGTTGGATGTGGCATTTAGCTGAAGCTGG
|
2569703ACGTTGGATGATAACCCTTGGACGCCGATCACGTTGGATGTTAGACGAAAAAGGCGCCAC
|
1799969ACGTTGGATGAACCTCTGGTCCCCCAGTGCACGTTGGATGTCCTAGAGGTGGACACGCAG
|
1059849ACGTTGGATGAAGCTGAGGCCACAGGGAGACGTTGGATGAGAGGGAATGGATGCAGAAG
|
3093035ACGTTGGATGTAGAAAGCAGTGCGATCTGGACGTTGGATGGGAGACATAGCGAGATTCTG
|
281439ACGTTGGATGGCTCGCTGGCACTTTCGTCACGTTGGATGGAGCCATACCTCTAAGCACC
|
281432ACGTTGGATGAGCTGGGACTTTCCTTCTTGACGTTGGATGGCCTTCAGCTATCTAATCCC
|
901886ACGTTGGATGTACGCGATCTGGTCGCTCTGACGTTGGATGTTCAGGCCCCACCTTCTGTT
|
5030382ACGTTGGATGACTCACAGAGCACATTCACGACGTTGGATGAGATCTTGAGGGCACCTACC
|
2569693ACGTTGGATGGTGTCTACTCAGCGTGTGTGACGTTGGATGCTTGTTCTCGCGTGGATGTC
|
2569702ACGTTGGATGACCCTCCAGACCTTGAACCAACGTTGGATGGTCAAGGACGTAACGCTAAC
|
3093030ACGTTGGATGACTTCCTCCCCCAAGAAAACACGTTGGATGAGAGACCCAGAAGGTCATAG
|
2075741ACGTTGGATGAGACCCAGTGTCTCTCCTGTACGTTGGATGAAGATGCCAGTCCGTGGACC
|
11549918ACGTTGGATGTAGATGGTCACGTTCTCCCGACGTTGGATGACAGCTAGCGCAGAGCAGGA
|
TABLE 14
|
|
|
dbSNP rs#
Extend Primer
Term Mix
|
|
|
1801714
CCTTCAGCAGGAGCTGGGCCCTC
ACT
|
|
2228615
TAACCTGCGCAGCTGGG
ACT
|
|
2569703
GAGGTGTCACGCTAGTCGAG
ACT
|
|
1799969
CTCCGAGACTGGGAACAGCC
ACG
|
|
1059849
AGGGGCGACTCCACGGA
ACT
|
|
3093035
CTGAGTCCGGATCAGAA
ACG
|
|
281439
GTCCCGCCCCCTCCGTCGCGTGC
ACT
|
|
281432
GGAGTCATGGAGGGTTT
ACT
|
|
901886
TCCGCAGCTCTTTGAAC
ACT
|
|
5030382
CACATTCACGGTCACCT
ACG
|
|
2569693
CCTTCTGCTCGGTGGGTGG
ACT
|
|
2569702
ACCTTGAACCAGATAGAA
ACT
|
|
3093030
AAACATTGTGGGTTGATGG
ACG
|
|
2075741
CCCGGGTACCTCCTTACGCT
ACT
|
|
11549918
CCCCAGGGTGACGTTGCAGA
ACG
|
|
Table 15, below, shows the case and control allele frequencies along with the p-values for the SNPs genotyped. The disease associated allele of column 4 is in bold and the disease associated amino acid of column 5 is also in bold. The chromosome positions provided correspond to NCBI's Build 34.
TABLE 15
|
|
Genotyping Results
Breast
Position inAminoCancer
SEQ IDChromosomeAllelesAcidAF FOddsAssociated
dbSNP rs#NO: 1Position(A1/A2)ChangeAF F casecontrolp-valueRatioAllele
|
18017143660810240417T/CL352PT = 0.010T = 0.0300.07342.26C
C = 0.990C = 0.097
22286154476810248577A/GT348AA = 0.340A = 0.4300.002361.47G
G = 0.660G = 0.570
25697034562710265227G/CG = 0.508G = 0.5810.0191.34C
C = 0.492C = 0.419
17999693619210255792G/AG241RG = 0.912G = 0.8830.120.723G
A = 0.088A = 0.117
10598491205410231654A/GA = 0.443A = 0.3640.009960.719A
G = 0.557G = 0.636
30930352437310243973G/AG = 0.941G = 0.9510.4661.22A
A = 0.059A = 0.049
2814394151010261110C/GC = 0.765C = 0.7810.5631.09G
G = 0.235G = 0.219
2814323205810251658C/GC = 0.549C = 0.5540.8761.02G
G = 0.451G = 0.446
9018864353110263131T/CT = 0.557T = 0.4830.01770.741T
C = 0.443C = 0.517
50303823708310256683G/AG = 0.616G = 0.5360.01020.721G
A = 0.384A = 0.464
25696934130410260904T/CT = 0.35T = 0.4510.00121.53C
C = 0.65C = 0.549
25697024534710264947T/CT = 0.667T = 0.5620.0008290.643T
C = 0.333C = 0.438
30930303880310258403C/TC = 0.613C = 0.5410.02350.745C
T = 0.387T = 0.459
20757414249810262098C/GC = 0.392C = 0.4660.01681.35G
G = 0.608G = 0.534
115499184433810263938G/AG = 0.663G = 0.5580.0006130.642G
A = 0.337A = 0.442
|
Example 5
MAPK10 Proximal SNPs
It has been discovered that a polymorphic variation (rs1541998) in a region that encodes MAPK10 is associated with the occurrence of breast cancer (see Examples 1 and 2). Subsequently, SNPs proximal to the incident SNP (rs1541998) were identified and allelotyped in breast cancer sample sets and control sample sets as described in Examples 1 and 2. Approximately ninety-two allelic variants located within the MAPK10 region were identified and allelotyped. The polymorphic variants are set forth in Table 16. The chromosome position provided in column four of Table 16 is based on Genome “Build 34” of NCBI's GenBank.
TABLE 16
|
|
Position in
SEQ IDChromosomeAlleleGenomeDeduced
dbSNP rs#NO: 2ChromosomePositionVariantsLetterIupac
|
|
2575681206487372306c/tgR
25756801505487373605a/gtY
25895053796487375896c/taR
25895043950487376050g/atY
21645384527487376627t/caR
25756797588487379688a/gtY
103058482487380582a/taW
28694089016487381116c/ggS
29040869018487381118c/ttY
9346489747487381847t/cgR
258951112207487384307g/agR
206058913040487385140g/atY
216453713492487385592t/cgR
257567813802487385902a/ctK
257567713918487386018g/cgS
258951014153487386253a/gcY
258950914370487386470t/gcM
216453615068487387168a/ctK
216453515474487387574t/aaW
194673417117487389217c/gcS
258952517777487389877g/agR
258952319497487391597c/taR
375597019646487391746a/caM
MAPK10-AA21751487393851a/cgK
257567522185487394285g/atY
120222703487394803t/ccY
120122763487394863a/gaR
258951623391487395491g/taM
257567423841487395941a/taW
258951523883487395983g/cgS
373336724132487396232c/tcY
95824169487396269c/tcY
258950625987487398087g/atY
143652426072487398172a/gcY
257567226376487398476c/tgR
258951826614487398714g/acY
377516426727487398827t/gtK
258951426827487398927g/acY
377516627084487399184t/ctY
MAPK10-AB30965487403065g/acY
377516732436487404536c/tcY
382203532821487404921t/atW
377516832979487405079a/ttW
377516933572487405672t/ctY
204365035142487407242a/gcY
204364935237487407337t/gcM
377517036014487408114t/atW
154199836439487408539c/taR
MAPK10-AC36838487408938g/aaR
MAPK10-AD36889487408989g/agR
MAPK10-AE38639487410739t/ctY
228259938657487410757t/gaM
MAPK10-AF38865487410965t/ctY
MAPK10-AG38885487410985a/ggR
MAPK10-AH38943487411043t/ctY
MAPK10-AI39035487411135t/ccY
MAPK10-AJ39046487411146t/ctY
228259839218487411318c/tgR
228259739241487411341g/atY
377517140105487412205a/caM
377517240240487412340c/ttY
377517341162487413262t/ctY
377517442477487414577a/caM
146987046191487418291g/ccS
143652250467487422567t/caR
194673352934487425034g/acY
98336254730487426830t/ccY
375597158283487430383c/ttY
382203658378487430478c/ggS
377517559505487431605g/aaR
143652560229487432329g/agR
382203761108487433208c/gcS
377517662587487434687g/aaR
99359363133487435233c/tcY
143652763616487435716c/tcY
143652965377487437477t/ccY
377518065442487437542a/caM
377518165548487437648t/ggK
377518265878487437978t/ggK
377518366222487438322g/aaR
377518466354487438454a/gaR
73324567224487439324a/taW
377518568198487440298t/ggK
156115468729487440829t/ccY
377518669058487441158a/ccM
377518769527487441627t/ctY
101077870774487442874a/gtY
228259671232487443332t/atW
228259571943487444043a/ctK
211804473397487445497a/taW
146986976322487448422c/tcY
MAPK10-AK110704487482804a/gtY
|
Assay for Verifing and Allelotyping SNPs
The methods used to verify and allelotype the proximal SNPs of Table 16 are the same methods described in Examples 1 and 2 herein. The PCR primers and extend primers used in these assays are provided in Table 17 and Table 18, respectively.
TABLE 17
|
|
dbSNP rs#Forward PCR primerReverse PCR primer
|
|
2575681ACGTTGGATGTTATATAGCCTTCTTTTCTCACGTTGGATGTTCACTGCTAACATGCATGG
|
2575680ACGTTGGATGGAGCCCAATACAATCAGGTGACGTTGGATGGCCCTGAAGTTTTTGAATGG
|
2589505ACGTTGGATGCATTTTATGAGAAGATGCACACGTTGGATGAGACTGTAGCCTAAATGAGG
|
2589504ACGTTGGATGCTGTGTGATTTGGACAACCCACGTTGGATGGGATAGGAAACATATTAAGG
|
2164538ACGTTGGATGAGAGGTCATCTTAATGGGCCACGTTGGATGTACTGCAGAGCTCTCCCTTG
|
2575679ACGTTGGATGTAAGCCAGTAACACATGCCGACGTTGGATGCTTTCCTGCTGCATTTAGTG
|
10305ACGTTGGATGGGTGAAGCTTGAAAGCAAGCACGTTGGATGTTCAAGAATTATTTTATTGC
AAGTC
|
2869408ACGTTGGATGGCTTTGAATTACTCTGTCCCACGTTGGATGTCCCAGTACCTAAGTAGCAG
|
2904086ACGTTGGATGGCTTTGAATTACTCTGTCCCACGTTGGATGTCCCAGTACCTAAGTAGCAG
|
934648ACGTTGGATGTGTACTGCTTTCATCCTTGCACGTTGGATGACTGGTTGATACCATAGGAC
|
2589511ACGTTGGATGGTAGAGCTGACATCATAGGCACGTTGGATGCCTACTGTGTTAGCCTCACT
|
2060589ACGTTGGATGACAACTACGTGTAACTGTCCACGTTGGATGCCAATACCTTTAACACCCAAC
|
2164537ACGTTGGATGAACACACTTAGTACCCACGCACGTTGGATGCAAGGCAAAATGTTTCCAGC
|
2575678ACGTTGGATGAAGCACCATTTGTGGCTCAGACGTTGGATGCTTCAAGAGGCCATACAGAC
|
2575677ACGTTGGATGGAAGGATAAGCCACAGTGAGACGTTGGATGGATGCCAATTTGGTTTGCCC
|
2589510ACGTTGGATGAATGGCATGGGAACTTGGACACGTTGGATGTGCACCACACTGAAGTGATC
|
2589509ACGTTGGATGATACGCAGGTTGTAGAGAGGACGTTGGATGTGAATCATGGTTGCCTCCTG
|
2164536ACGTTGGATGCTGGAGAACAAAAGACCACCACGTTGGATGGTGATGAAAACCATGTGAGC
|
2164535ACGTTGGATGGAATGATGTAAACGTTGGAGACGTTGGATGACCAGCACTATTACCCATGC
|
1946734ACGTTGGATGGTCAGCAAATCTGCCTTCACACGTTGGATGAACCTGCTTTGTGGTCTTCG
|
2589525ACGTTGGATGGTATTTAAATTAGTGGTGTGACGTTGGATGAAGAACATTGAAAGAAGCAG
|
2589523ACGTTGGATGAGCAGGGTTAAATTTCCCAGACGTTGGATGTCATGTAGCTAAACAAAGGC
|
3755970ACGTTGGATGGTGACCATGTAGAAATCTGTGACGTTGGATGTACAACTAGTATCTACAGAC
|
MAPK10-AAACGTTGGATGCTTGGGAAATAACAGGTGACACGTTGGATGCACTTGTCTGTCTTAACACAC
|
2575675ACGTTGGATGTTGGGAAGGTACTAACAGCGACGTTGGATGTCGTACCTGCATAAGTGGTG
|
1202ACGTTGGATGTCAAGCAATAGAGACCACAGACGTTGGATGTAATCTCAGAATGGCAGCAC
|
1201ACGTTGGATGCCTGTGGTCTCTATTGCTTGACGTTGGATGTGCCAGTGCTCTGAAAACTG
|
2589516ACGTTGGATGACTCACACTGTGGTTTGGGGACGTTGGATGCATACTCTGCCAAAGTTTTA
|
2575674ACGTTGGATGCTCTCCTACTCTTTACTGTCACGTTGGATGGTGGGTAACAGTTTTCAGGC
|
2589515ACGTTGGATGGCCAAACCATTTTGTGCCTGACGTTGGATGCACCTGTATACCAATTTGTAG
|
3733367ACGTTGGATGCAGATGGGTTTATGTCAGAGACGTTGGATGGGCTCTACCAAGACATAATG
|
958ACGTTGGATGCCCAGTGCATTATGTCTTGGACGTTGGATGATCCGCATGTGTCTGTATTC
|
2589506ACGTTGGATGTGTTATGCGGGAGTATAAGGACGTTGGATGGCAACTCAGCTAGCCTTTAC
|
1436524ACGTTGGATGATTGTTTCCAGGGTGCTCTGACGTTGGATGGAGTTGCCAGTAGCTTTGAG
|
2575672ACGTTGGATGCTCCAGGAGCAAGGATTATGACGTTGGATGATAGTGTTATCACATAGACC
|
2589518ACGTTGGATGAATGATATGCACCGATCTTCACGTTGGATGCCAGGCAAAAAGAATGACCG
|
3775164ACGTTGGATGAAGTTTCCCTGGTCGTGATCACGTTGGATGGAACATGAAAAATTCATAAGC
|
2589514ACGTTGGATGCTTAAATGTCTCTAGAAAAGGACGTTGGATGTATACATTGTCCTGATAGAG
|
3775166ACGTTGGATGCTGAGGAGTCCATCATAGTGACGTTGGATGCTGTTTTTCACCCCCGATTC
|
MAPK10-ABACGTTGGATGGATAAGTATTGGCTTAATCTGACGTTGGATGTTTCATTGCTCATGGATTAG
|
3775167ACGTTGGATGGCTTCTGATTTTATATGGCACACGTTGGATGGAAACAAGCAGATGTCATGG
|
3822035ACGTTGGATGATAAATGCCTCCTTGCCTGCACGTTGGATGGAACTCCTGTTTATTGCCTAC
|
3775168ACGTTGGATGTCTCACATTGACTGGACAACACGTTGGATGCCAAGCAGTTTGCGAAAATC
|
3775169ACGTTGGATGATGCTGAACAACAGGATGGGACGTTGGATGGGGAGAGAATGGTTGCATAT
|
2043650ACGTTGGATGCTGTGCCTTGCACATAGTAGACGTTGGATGGCTGAGGGAGAAATTGAGTG
|
2043649ACGTTGGATGGTCCTACTAGTCCCTGTATGACGTTGGATGGCACTACATGGGACACAAAG
|
3775170ACGTTGGATGCCCATTTTTGCTAGCAGGAGACGTTGGATGCCTAAGACCTATGCTCTCAC
|
1541998ACGTTGGATGCTGATTATTCTGATGGTAATGACGTTGGATGGCCCATGTTAACATTTTCTTC
|
MAPK10-ACACGTTGGATGCTCTCTGCTAATTACAAGGCACGTTGGATGTACGTTTTGATGGGGTTGAG
|
MAPK10-ADACGTTGGATGAGATACCTATTTGTGCCAGGACGTTGGATGTACGTTTTGATGGGGTTGAG
|
MAPK10-AEACGTTGGATGTGTCTTTTCATGCCGAAAGCACGTTGGATGCGACAAACACTGACAATCAG
|
2282599ACGTTGGATGGACTGCTATTCTCTTAGACCACGTTGGATGCATTCTTGAGCAAATGTGAC
|
MAPK10-AFACGTTGGATGGTCATATATCTGAGGTGGAGACGTTGGATGCAAGGTATTCTCGTGCATTG
|
MAPK10-AGACGTTGGATGGTCATATATCTGAGGTGGAGACGTTGGATGCAAGGTATTCTCGTGCATTG
|
MAPK10-AHACGTTGGATGCGAAATAAATGAGGGCAAGGACGTTGGATGGGAGGCTGCCGAATAAAAAC
|
MAPK10-AIACGTTGGATGTGGGTCAGCAGCAAATATTGACGTTGGATGTGCCCTCATTTATTTCGGTG
|
MAPK10-AJACGTTGGATGTGGGTCAGCAGCAAATATTGACGTTGGATGTGCCCTCATTTATTTCGGTG
|
2282598ACGTTGGATGGTGAATGAAGGAAAAGTAGCACGTTGGATGCACGCCTAAGCAATTAATGAC
|
2282597ACGTTGGATGACACTTGATTACAATGGCCCACGTTGGATGGCATGGTTCTGTTATAAGGC
|
3775171ACGTTGGATGCTGTCATGATTCAAGCTACCACGTTGGATGTTTGGCTCATGAACAGCACC
|
3775172ACGTTGGATGCTGCAAAGTATCTGGCTATGACGTTGGATGGCTCCGTGAGTAGTTATTTC
|
3775173ACGTTGGATGTAAATTTGCAGAGGCCGTCGACGTTGGATGCAAGAGGGCTGCTTTAAACC
|
3775174ACGTTGGATGCATCCTTGATCCACCCTTTGACGTTGGATGCATGTCGTCAGAAGTGACAA
|
1469870ACGTTGGATGATGGCACAGTTTAGCATGTCACGTTGGATGATACTGAGCTCCATTTTGGG
|
1436522ACGTTGGATGATTGGAAGGAGGAAGCATAGACGTTGGATGGGAATTGAAATTGGCATTGC
|
1946733ACGTTGGATGTAGCTTCTAAACATCTCTTGACGTTGGATGGCAGGAGGATAGATCTGTAG
|
983362ACGTTGGATGCACATTGCTCCCTCCTTTACACGTTGGATGGCGGCCGAAGAGTACTATTT
|
3755971ACGTTGGATGGTGGTAACAGATTGCTGTACACGTTGGATGGCGTAAAGAACTTTTGGTGAC
|
3822036ACGTTGGATGCAACACATACCTTAGGTAAGAACGTTGGATGCTGAATTCCTTCGATGTTCC
|
3775175ACGTTGGATGCATTATAAAAACAGTTTCTTGACGTTGGATGGAGTAGACAGTGGCTATTAA
|
1436525ACGTTGGATGGCTTACACTAGCTACTTGGGACGTTGGATGGTGCAATCTTGGTTCACTGC
|
3822037ACGTTGGATGTCCCACCCTGACTTCTTTGCACGTTGGATGGTAATCCATAAACTGTGGGAG
|
3775176ACGTTGGATGTAGTCCAAGTATTTCCCAAGACGTTGGATGAAAAGGTCACCAGTGACCTG
|
993593ACGTTGGATGTAGGCACTGCAGATCTTTTCACGTTGGATGCACTAAAATAATAAGAAAGC
TC
|
1436527ACGTTGGATGCTGTATAGAGAGCTGTTTGCACGTTGGATGAGCACTGTGAGTTAAACCTG
|
1436529ACGTTGGATGAATGTTGGACCACATGTACGACGTTGGATGCTATGGCAGCAGAAGAGTAG
|
3775180ACGTTGGATGTCCACTGAATGTGCACTTCCACGTTGGATGCAAGACTGTAGCCCTACAAC
|
3775181ACGTTGGATGCTTCTGCCAAGACTATCAGGACGTTGGATGGTAAGCATCCCCCTAATAAT
|
3775182ACGTTGGATGGCTGGACTCTATTAGGCCATACGTTGGATGGATATCTCCCTCCTATTGGC
|
3775183ACGTTGGATGTGCAGATATGTAGGCCAAGCACGTTGGATGGATCTCTGATCTTAGACCAC
|
3775184ACGTTGGATGGTTCTACTTTGACCACAGGCACGTTGGATGGACCAGCAACCATGATGAAG
|
733245ACGTTGGATGTAGTCTAGTGGAGGATGTCGACGTTGGATGCCAGCTATAATGTAGACCAC
|
3775185ACGTTGGATGTGTGGAATCTATAATGTGTCACGTTGGATGACCTACCTCTTCTTTGCCAG
|
1561154ACGTTGGATGAATAGAAGATGCTCTAACTCACGTTGGATGGAAGATGCAAATAAGTCAACC
|
3775186ACGTTGGATGGATATGCTATGTGTGCTAAGACGTTGGATGTTGTACTTTGGTAGTTTGGG
|
3775187ACGTTGGATGAATCATGATCCCAGGGCAAGACGTTGGATGTAGCACCTTCAGGATCTTTC
|
1010778ACGTTGGATGGGATTTGTTCTTAATCTTTCACGTTGGATGCAGAGGAAAGAAAACTGAAAG
|
2282596ACGTTGGATGGGTGGCTTTGTGAAACCTTGACGTTGGATGTCATACTGATCAACCTGAAG
|
2282595ACGTTGGATGAAGGAAATTTGTCAGAGAGGACGTTGGATGCTTTTCCATCACATCAAGGG
|
2118044ACGTTGGATGGTCATTGCCTCTAGCTAGTGACGTTGGATGAACAACTTGGCTAATTCTAC
|
1469869ACGTTGGATGTTCGATATATCAGAGCCTTGACGTTGGATGCATGGCGAGGAAATCTGTTT
|
MAPK10-AKACGTTGGATGTTTCTCTCGTTTCCTCTGTCACGTTGGATGACTTACACATCTTGGAACTC
|
TABLE 18
|
|
|
dbSNP rs#
Extend Primer
Term Mix
|
|
|
257568
TTTCTTTTCTCTTTTAGGAATCT
ACG
|
|
2575680
GGATGCATGGTTTCTCTAAT
ACT
|
|
2589505
GTTTTAGCATAATTGCTTCTTTA
ACG
|
|
2589504
GTGCTAGGATCCTCAGT
ACG
|
|
2164538
GTCACATTCTTACCCTC
ACT
|
|
2575679
CTTCCTGGACATTAAATTGT
ACT
|
|
10305
AGCTAAATTGCAACAACA
ACG
|
|
2869408
CGAATCTCTTTAACTGCTG
ACT
|
|
2904086
GAATCTCTTTAACTGCTGGA
ACG
|
|
934648
ACTCTCCCACTGAGCAAGC
ACT
|
|
2589511
CTCCAAAGGATACCCAGA
ACG
|
|
2060589
ACTCTATCCATGTCTACAC
ACG
|
|
2164537
CGGCTTCTACTCTCTTATTCA
ACT
|
|
2575678
TGTGGCTCAGGTCCAGG
ACT
|
|
2575677
GGAATGAGGGCAACAGGA
ACT
|
|
2589510
TTTGGCAACAGGTAACCAGC
ACT
|
|
2589509
AGGGCTGCAGGGAAGAT
ACT
|
|
2164536
CCTGTGTTCCTTTGTATTTATAT
ACT
|
|
2164535
GATAAATGTGAGATTGAGAGA
CGT
|
|
1946734
GCATTCTAGTGGAGAAGTCA
ACT
|
|
2589525
TTAGTGGTGTGACTTGCA
ACG
|
|
2589523
TTTCCCAGATTAATTATCAGATT
ACG
|
|
3755970
GGTTTCTTCTAAAACTGACCT
ACT
|
|
MAPK10-AA
GGTGACTATTTAAGAAATATTTGG
ACT
|
|
2575675
GTTCTTGCCTGGTTTAC
ACG
|
|
1202
CCACCTGCACCATCGCCAT
ACT
|
|
1201
TTCTATTGCTTGAAGAGAGAAAG
ACT
|
|
2589516
GGTTTGGGGGTTTCATT
CGT
|
|
2575674
TATTCACACCTGCCTTC
CGT
|
|
2589515
GAAAACTGTTACCCACTC
ACT
|
|
3733367
GTAATAGATCACATGAAATGGAC
ACG
|
|
958
TTATGTCTTGGTAGAGCC
ACG
|
|
2589506
GAGAAGAAACCTGCCCA
ACG
|
|
1436524
CCAGGGTGCTCTGGTTTAATT
ACT
|
|
2575672
CAAGGATTATGTTAACCACT
ACG
|
|
2589518
TGCACCGATCTTCAAATAAA
ACG
|
|
3775164
TTTTTTGGGATCTTGATATTTTTA
ACT
|
|
2589514
AGAAAAGGTTTTTAAAGTCCTC
ACG
|
|
3775166
AACTTATGAAAGAATATGAAGGAT
ACT
|
|
MAPK10-AB
ATTGGCTTAATCTGTACATCAATT
ACG
|
|
3775167
TAAGAGAAGTCTTCAGTGCTT
ACG
|
|
3822035
CTGGATGATCCATTCAAG
CGT
|
|
3775168
ACTGGACAACTGAACAC
CGT
|
|
3775169
GCAGAGATTTTTCAAAATCTCTAA
ACT
|
|
2043650
GCACATAGTAGTAGCTCA
ACT
|
|
2043649
CCTCTTGTCTTATTATCCC
ACT
|
|
3775170
TTTTTAAAGCTGAAAATAAACCA
CGT
|
|
1541998
ATTATTCTGATGGTAATGATCCAG
ACG
|
|
MAPK10-AC
TAGAGCAGTAAAGGAATCTCAA
ACG
|
|
MAPK10-AD
TATTTGTGCCAGGCTCTCTG
ACG
|
|
MAPK10-AE
CATGCCGAAAGCAATGTCAC
ACT
|
|
2282599
CTAAAACTTCATCTGTCTTTTCA
ACT
|
|
MAPK10-AF
TCTGAGGTGGAGGCTGCC
ACT
|
|
MAPK10-AG
TCTGAGGTGGAGGCTGCC
ACT
|
|
MAPK10-AH
GGGCAAGGTATTCTCGTGC
ACT
|
|
MAPK10-AI
AATGAATCCTCCATAAGTTTACA
ACT
|
|
MAPK10-AJ
TTGCAATATGAATGAATCCTCC
ACT
|
|
2282598
AGGAAAAGTAGCTTCTGGG
ACG
|
|
2282597
CAGAAGCTACTTTTCCTTCA
ACG
|
|
3775171
GAATTAGAGAAGGGTCACT
ACT
|
|
3775172
TATGAAAATAGAAGACTTTGCC
ACG
|
|
3775173
GCCGTCGAACAAATACT
ACT
|
|
3775174
GCTTCTCTAAGTACAGCTC
ACT
|
|
1469870
CTTATATTCTCTGTGGCACCAA
ACT
|
|
1436522
GAGGAAGCATAGATTTGGTGT
ACT
|
|
1946733
CTAAACATCTCTTGAATATTCTG
ACG
|
|
983362
GCTCAAATGTTACCTTCTCAAA
ACT
|
|
3755971
AACAGCATTCTGGCATATA
ACG
|
|
3822036
CAGAAAAAGTGCTTGAGG
ACT
|
|
3775175
CAGTTTCTTGTGGTCCC
ACG
|
|
1436525
GGCTTAAACCTGGGAGG
ACG
|
|
3822037
TTTGCTTATTTCATAGAAGGAAT
ACT
|
|
3775176
TATTTCCCAAGTGCCCA
ACG
|
|
993593
AGCAACAGAGGCTTTTTCTA
ACG
|
|
1436527
GAGCTGTTTGCATTTATAACTCA
ACG
|
|
1436529
ACCACATGTACGTAAGGGGA
ACT
|
|
3775180
TATGTGTTGATGTCACTCTT
ACT
|
|
3775181
GGTTGGTATAGTACTTGCGAT
ACT
|
|
3775182
CTGTCAGTTGCCTTAGG
ACT
|
|
3775183
AGTCAAGACCAGCTGGG
ACG
|
|
3775184
CTCTTTCTTCTGATCCC
ACT
|
|
733245
CCTTAGATTCCCAAACAAAAC CGT
|
|
3775185
TTTGGTTTAAACTAATGACACTA
ACT
|
|
1561154
AGATGCTCTAACTCTGGTTCA ACT
|
|
3775186
GCTAAGCTAUAGTTATACTACGA
ACT
|
|
3775187
AGTGCATTACAGTGGTC
ACT
|
|
1010778
TTGAAATACTGTTTGTTTCCCCAA
ACT
|
|
2282596
GAAACCTTGCATGAACT
CGT
|
|
2282595
AAGTATGGAATAGTATCTTCCT ACT
|
|
2118044
GTGGGGTTAGATATTATTTCCTGA
CGT
|
|
1469869
AAACACCATCTACTCTGAAGAA ACG
|
|
MAPK10-AK
CGTTTCCTCTGTCCCTTCC
ACT
|
|
Genetic Analysis of Allelotyping Results
Allelotyping results are shown for cases and controls in Table 19. The allele frequency for the A2 allele is noted in the fifth and sixth columns for breast cancer pools and control pools, respectively, where “AF” is allele frequency. SNPs with blank allele frequencies were untyped.
TABLE 19
|
|
Position inBreast Cancer
SEQ IDChromosomeA1/A2Associated
dbSNP rs#NO: 2PositionAlleleCase AFControl AFp-ValueORAllele
|
|
257568120687372306C/TC = 0.610C = 0.6310.4991.09T
T = 0.390T = 0.369
2575680150587373605A/GA = 0.404A = 0.4110.841.03G
G = 0.596G = 0.589
2589505379687375896C/TC = 0.515C = 0.5000.6550.94C
T = 0.485T = 0.500
2589504395087376050G/AG = 0.744G = 0.7250.5060.91G
A = 0.256A = 0.275
2164538452787376627T/CT = 0.595T = 0.5860.7750.96T
C = 0.405C = 0.414
2575679758887379688A/GA = 0.968A = 0.9880.1852.68G
G = 0.032G = 0.012
10305848287380582A/TA = 0.303A =
T = 0.697T =
2869408901687381116C/GC = 0.292C = 0.2870.8790.98C
G = 0.708G = 0.713
2904086901887381118C/TC = 0.003C = 0.0020.8220.40C
T = 0.997T = 0.998
934648974787381847T/CT = 0.345T = 0.3370.7860.96T
C = 0.655C = 0.663
25895111220787384307G/AG = 0.599G =
A = 0.401A =
20605891304087385140G/AG = 0.001G = 0.0080.43113.10A
A = 0.999A = 0.992
21645371349287385592T/CT = 0.737T = 0.6950.1970.81T
C = 0.263C = 0.305
25756781380287385902A/CA = 0.886A = 0.9280.1811.66C
C = 0.114C = 0.072
25756771391887386018G/CG = 0.080G = 0.0270.002520.32G
C = 0.920C = 0.973
25895101415387386253A/GA = 0.592A = 0.5820.7670.96A
G = 0.408G = 0.418
25895091437087386470T/GT = 0.799T = 0.7850.5990.92T
G = 0.201G = 0.215
21645361506887387168A/CA = 0.378A = 0.3980.5091.09C
C = 0.622C = 0.602
21645351547487387574T/AT = 0.430T = 0.4260.8910.98T
A = 0.570A = 0.574
19467341711787389217C/GC = 0.003C = 0.0010.7820.22C
G = 0.997G = 0.999
25895251777787389877G/AG = 0.607G = 0.6060.9831.00G
A = 0.393A = 0.394
25895231949787391597C/TC = 0.225C = 0.1860.1390.79C
T = 0.775T = 0.814
37559701964687391746A/CA = 0.880A = 0.8940.5251.15C
C = 0.120C = 0.106
MAPK10-AA2175187393851A/CA = 0.014A =
C = 0.986C =
25756752218587394285G/AG = 0.347G = 0.3050.1540.83G
A = 0.653A = 0.695
12022270387394803T/CT = 0.238T = 0.2410.9091.02C
C = 0.762C = 0.759
12012276387394863A/GA = 0.872A = 0.8830.6111.11G
G = 0.128G = 0.117
25895162339187395491G/TG = 0.575G = 0.5190.07080.80G
T = 0.425T = 0.481
25756742384187395941A/TA = 0.419A = 0.3400.01070.71A
T = 0.581T = 0.660
25895152388387395983G/CG = 0.586G = 0.5440.2110.84G
C = 0.414C = 0.456
37333672413287396232C/TC = 1.000C = 1.0000.9570.54C
T = 0.000T = 0.000
9582416987396269C/TC = 0.833C = 0.8420.691.07T
T = 0.167T = 0.158
25895062598787398087G/AG = 0.568G = 0.510.06570.79G
A = 0.432A = 0.490
14365242607287398172A/GA = 0.341A = 0.2480.001260.64A
G = 0.659G = 0.752
25756722637687398476C/TC = 0.726C = 0.8140.001251.65T
T = 0.274T = 0.186
25895182661487398714G/AG = 0.806G = 0.8680.009841.58A
A = 0.194A = 0.132
37751642672787398827T/GT = 0.934T = 0.9210.5230.83T
G = 0.066G = 0.079
25895142682787398927G/AG = 0.556G = 0.6390.01991.41A
A = 0.444A = 0.361
37751662708487399184T/CT = 0.751T = 0.8330.003511.65C
C = 0.249C = 0.167
MAPK10-AB3096587403065G/AG = 0.814G = 0.8610.04531.42A
A = 0.186A = 0.139
37751673243687404536C/TC = 0.845C = 0.8500.8581.04T
T = 0.155T = 0.150
38220353282187404921T/AT = 0.998T = 1.0000.761A
A = 0.002A = 0
37751683297987405079A/TA = 0.380A = 0.2610.002520.57A
T = 0.620T = 0.739
37751693357287405672T/CT = 0.829T = 0.8700.1061.38C
C = 0.171C = 0.130
20436503514287407242A/GA = 0.308A = 0.2150.001020.62A
G = 0.692G = 0.785
20436493523787407337T/GT = 0.302T = 0.2410.03050.73T
G = 0.698G = 0.759
37751703601487408114T/AT = 0.791T = 0.7840.7820.96T
A = 0.209A = 0.216
15419983643987408539C/TC = 0.283C = 0.2280.06040.75C
T = 0.717T = 0.772
MAPK10-AC3683887408938G/AG = 0.034G = 0.0130.1760.36G
A = 0.966A = 0.987
MAPK10-AD3688987408989G/AG = 0.923G = 0.9580.0811.90A
A = 0.077A = 0.042
MAPK10-AE3863987410739T/CT = 0.919T = 0.9310.4911.20C
C = 0.081C = 0.069
22825993865787410757T/GT = 1.000T = 1.0000.9760.64T
G = 0.000G = 0.000
MAPK10-AF3886587410965T/CT = 0.300T = 0.2220.005360.66T
C = 0.700C = 0.778
MAPK10-AG3888587410985A/GA = 0.249A = 0.1920.06260.71A
G = 0.751G = 0.808
MAPK10-AH3894387411043T/CT = 0.945T = 0.9530.6491.17C
C = 0.055C = 0.047
MAPK10-AI3903587411135T/CT = 0.128T = 0.0580.0004130.41T
C = 0.872C = 0.942
MAPK10-AJ3904687411146T/CT = 0.823T = 0.8770.02411.53C
C = 0.177C = 0.123
22825983921887411318C/TC = 0.971C = 0.9660.7350.86C
T = 0.029T = 0.034
22825973924187411341G/AG = 0.184G = 0.1970.6131.09A
A = 0.816A = 0.803
37751714010587412205A/CA = 1.000A = 1.0000.9980.94A
C = 0.000C = 0.000
37751724024087412340C/TC = 0.003C = 0.0030.9950.98C
T = 0.997T = 0.997
37751734116287413262T/CT = 0.841T = 0.8520.6521.09C
C = 0.159C = 0.148
37751744247787414577A/CA = 1.000A = 0.9990.9470.55A
C = 0.000C = 0.001
14698704619187418291G/CG = 0.884G = 0.9340.0131.85C
C = 0.116C = 0.066
14365225046787422567T/CT = 0.84T = 0.8760.1221.34C
C = 0.160C = 0.124
19467335293487425034G/AG = 0.763G = 0.7730.7091.06A
A = 0.237A = 0.227
9833625473087426830T/CT = 0.002T = 0.0030.9341.40C
C = 0.998C = 0.997
37559715828387430383C/TC = 0.001C = 0.0020.8783.66T
T = 0.999T = 0.998
38220365837887430478C/GC = 0C = 0.0010.944G
G = 1.000G = 0.999
37751755950587431605G/AG = 0.001G = 0.0050.674.64A
A = 0.999A = 0.995
14365256022987432329G/AG = 0.945G = 0.9610.2971.43A
A = 0.055A = 0.039
38220376110887433208C/GC = 0.054C = 0.0850.1021.61G
G = 0.946G = 0.915
37751766258787434687G/AG = 0.034G = 0.0880.02832.78A
A = 0.966A = 0.912
9935936313387435233C/TC = 0.998C = 1.0000.78999.16T
T = 0.002T = 0.000
14365276361687435716C/TC = 0.709C = 0.750.1551.23T
T = 0.291T = 0.250
14365296537787437477T/CT = 0.448T = 0.4630.6421.06C
C = 0.552C = 0.537
37751806544287437542A/CA = 1.000A = 1.0000.9574.50C
C = 0.000C = 0.000
37751816554887437648T/GT = 0.758T = 0.7290.360.86T
G = 0.242G = 0.271
37751826587887437978T/GT = 0.143T = 0.130.5920.90T
G = 0.857G = 0.870
37751836622287438322G/AG = 0.446G = 0.3920.130.80G
A = 0.554A = 0.608
37751846635487438454A/GA = 0.828A = 0.8180.7150.94A
G = 0.172G = 0.182
7332456722487439324A/TA = 0.002A = 0.0030.872.02T
T = 0.998T = 0.997
37751856819887440298T/GT = 0.003T = 0.0010.8460.32T
G = 0.997G = 0.999
15611546872987440829T/CT = 0.009T = 0.0080.9180.88T
C = 0.991C = 0.992
37751866905887441158A/CA = 0.005A = 0.0050.9810.95A
C = 0.995C = 0.995
37751876952787441627T/CT = 0.698T = 0.710.6921.06C
C = 0.302C = 0.290
10107787077487442874A/GA = 0.668A = 0.7240.07211.31G
G = 0.332G = 0.276
22825967123287443332T/AT = 0.265T = 0.2670.941.01A
A = 0.735A = 0.733
22825957194387444043A/CA = 1.000A = 1.0000.9840.00A
C = 0.000C = 0.000
21180447339787445497A/TA = 0.656A = 0.6810.4441.12T
T = 0.344T = 0.319
14698697632287448422C/TC = 0.615C = 0.6660.1031.24T
T = 0.385T = 0.334
MAPK10-AK11070487482804A/GA = 0.526A = 0.4880.2360.86A
G = 0.474G = 0.512
|
FIG. 1B shows proximal SNPs in and around the MAPK10 region for females. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIG. 1B can be determined by consulting Table 19. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.
To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10−8 were truncated at that value.
Finally, the gene or genes present in the loci region of the proximal SNPs as annotated by Locus Link (http address: www.ncbi.nlm.nih.gov/LocusLink/) are provided on the graph. The exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.
Example 6
KIAA0861 Proximal SNPs
It has been discovered that a polymorphic variation (rs2001449) in a gene encoding KIAA0861 is associated with the occurrence of breast cancer (see Examples 1 and 2). Subsequently, SNP's proximal to the incident SNP (rs2001449) were identified and allelotyped in breast cancer sample sets and control sample sets as described in Examples 1 and 2. A total of seventy-five allelic variants located within or nearby the KIAA0861 gene were identified and fifty-severn allelic variants were allelotyped. The polymorphic variants are set forth in Table 20. The chromosome position provided in column four of Table 20 is based on Genome “Build 34” of NCBI's GenBank.
TABLE 20
|
|
Position in
SEQ IDChromosomeAlleleGenomeDeduced
dbSNP rs#NO: 3ChromosomePositionVariantsLetterIupac
|
|
38117282463184201246t/ccY
38117293933184201393a/gaR
6026466283184201628c/gcS
48827775863184208586t/ccY
162967392233184210223a/ggR
67023299333184210933a/taW
575326101543184211154t/ccY
575386101753184211175c/gcS
684846108773184211877t/ccY
471365109073184211907g/cgS
496251112893184212289g/aaR
831246117933184212793t/ctY
831247118133184212813g/cgS
KIAA0861-AA135073184214507c/ggS
512071142493184215249c/tcY
1502761145863184215586a/caM
681516146473184215647c/ttY
683302150043184216004c/ttY
619424165733184217573t/ggK
620722168113184217811a/gaR
529055189213184219921a/gaR
664010196513184220651t/ggK
678454205653184221565c/tcY
2653845252393184226239g/aaR
472795257213184226721g/aaR
507079271333184228133g/agR
534333277783184228778t/ctY
535298279063184228906t/ctY
536213280003184229000g/aaR
831245300053184231005a/ggR
639690305203184231520t/ccY
684174321953184233195t/ccY
571761324393184233439c/gcS
1983421338583184234858t/ctY
4630966417163184242716c/ttY
2314415424503184243450t/gcM
6788196435543184244554g/agR
2103062442113184245211a/ggR
9827084447753184245775g/ccS
9864865449623184245962a/gaR
6804951453173184246317c/ttY
6770548457123184246712a/gaR
1403452459413184246941t/ccY
7609994465203184247520g/ttK
9838250471753184248175c/tcY
9863404480453184249045g/ttK
903950486363184249636c/atK
6787284486893184249689g/agR
2017340487043184249704a/gcY
2001449488493184249849g/cgS
1317288488503184249850g/agR
7635891499313184250931t/ggK
10704581515103184252510—/tttN
11371910515263184252526—/acN
10937118517583184252758a/gaR
7642053519753184252975c/ggS
3821522534753184254475a/gcY
2029926555243184256524t/cgR
1390831567543184257754t/gaM
7643890574733184258473a/ggR
11925606574973184258497a/ccM
9826325576133184258613g/aaR
6800429580233184259023g/agR
6803368588213184259821t/ccY
1353566596443184260644c/agK
2272115662173184267217g/aaR
2272116663443184267344g/agR
3732603673263184268326g/ccS
940055697773184270777a/caM
2314730835943184284594a/ggR
2030578845793184285579g/cgS
2049280856233184286623c/ttY
37326021268313184327831c/taR
22932031378783184338878a/ttW
76397051474553184348455g/ttK
|
Assays for Verifying and Allelotyping SNPs
The methods used to verify and allelotype the seventy-five proximal SNPs of Table 20 are the same methods described in Examples 1 and 2 herein. The PCR primers and extend primers used in these assays are provided in Table 21 and Table 22, respectively.
TABLE 21
|
|
dbSNP rs#Forward PCR primerReverse PCR primer
|
|
3811728ACGTTGGATGACGTGTCGGTCCCCTTTCATACGTTGGATGACGCGCCACACCTCCCTAC
|
3811729ACGTTGGATGTGGGCGAGGTTCTGCAGCGTACGTTGGATGGTTTCGTTTCTCCGGCACAG
|
602646ACGTTGGATGGAGGAGACCCAGGGTATGAGACGTTGGATGTCTGGGACCGTTTACCGCA
|
488277ACGTTGGATGCACACATTCTTCTCAAGTGCACGTTGGATGGGAGGGACACAATTTAACTC
|
1629673ACGTTGGATGGGCACCATGTGTGGCTAATTACGTTGGATGAAGGATCACGTGAAGTCAGG
|
670232ACGTTGGATGGAAGGTGGAGCAGACATTAGACGTTGGATGACCTTAGTTATACCAGGCAC
|
575326ACGTTGGATGACAGAGAGGCTTGGTCATACACGTTGGATGGGTGCTTGGTTGTGATTCTC
|
575386ACGTTGGATGATTCCTGCAGGTACTGTGTCACGTTGGATGTGAGCCCAAAACTACTGCTG
|
684846ACGTTGGATGACCACCAGATAAAATCCCTCACGTTGGATGAAGTTCCTCTGGTGGACAAC
|
471365ACGTTGGATGTGAGTGACATTTGTGTCACCACGTTGGATGCGGAGGATCTGAACAACTTC
|
496251ACGTTGGATGGGGAGTCATTCCAATACCAGACGTTGGATGGGAGTGAAAGGTCATATTGG
|
831246ACGTTGGATGCACAATCTGTTAGAATGGTGGACGTTGGATGCGTCAAGACTGAATGCATAG
|
831247ACGTTGGATGGAAAATATAGTCCTACACAAACGTTGGATGCGTCAAGACTGAATGCATAG
|
KIAA0861-AAACGTTGGATGGTTCTAATGTCACCCCTTCCACGTTGGATGCAATGTGGCAAATTCTCTGG
|
512071ACGTTGGATGCAAATCACCCCTGACAATTCACGTTGGATGACCAGCACACTCAGCTTTAG
|
1502761ACGTTGGATGCAGAAATATGAAGGTGGCCCACGTTGGATGACCTTGAGCTCTGAGCCCTT
|
681516ACGTTGGATGCTCCTCCTCAGAGGACTAACACGTTGGATGAGCCCAAGGACTCATACAAC
|
683302ACGTTGGATGAAACATGGCGAAACCCGGTCACGTTGGATGACCACGCCTGGCTAATTTTG
|
619424ACGTTGGATGACCGGGAGCTCCCAGTCTGACGTTGGATGTGGGAATCGGTTGAGAGCCG
|
620722ACGTTGGATGGCAGCAAAGAATTGCCCGGCACGTTGGATGTAAGGCGCCTGCAGAGGCGA
|
529055ACGTTGGATGCTGCAGTTATCTGGGTGAGCACGTTGGATGCCAGAACGTGGCTTGTTGGG
|
664010ACGTTGGATGTGGTACCTCCAGGTAAAATGACGTTGGATGTCCAGGCAGTCATTTTACCC
|
678454ACGTTGGATGTTCTCTGCGGAGGAAAGTGCACGTTGGATGTTAAGCCAGTCCCCACAAGG
|
2653845ACGTTGGATGATCACTTGGACTCAGGAAGCACGTTGGATGAGTCTTGCTCTGTTTCCAGG
|
472795ACGTTGGATGTCACCTGAGCATCAGACATGACGTTGGATGATAGTGGAAGGAGAAACGGG
|
507079ACGUGGATGAAGCCTCAGATGAGGCATACACGTTGGATGTCTGAAAGGGTTCAGGAAGG
|
534333ACGTTGGATGCGTTGATGCACTGAAGGGAGACGTTGGATGAGAGGCTAAATGTTGGCAGG
|
535298ACGTTGGATGCAATTGCTCAGACCTTCACCACGTTGGATGAATGCTAGAGACATTGCACC
|
536213ACGTTGGATGTGAGGACCTCATTATTGGTGACGTTGGATGCTGAGCAATCGAACTGCTAC
|
831245ACGTTGGATGCTAGAATTACAGGTGCACACACGTTGGATGGCCAAGATGGTGAAACCTTG
|
639690ACGTTGGATGGCATTTTACCACCATGTGGTTACGTTGGATGCCTTCATGTTAATTCTGCCC
|
684174ACGTTGGATGCTTTACTGAGTGGGCAAACGACGTTGGATGTCTAAGTGGAACTCAGCAGC
|
571761ACGTTGGATGAATATCCTAGGCTAGCAGTGACGTTGGATGGTGCATAAATACATGAATAG
|
1983421ACGTTGGATGTCCAGGTGTTATGGAGTCAGACGTTGGATGGGCTTCTTGTGCTGCTGTGT
|
4630966ACGTTGGATGTCAACAAAGATGCCAAGACCACGTTGGATGGTGGATATCCATTGTCCTAG
|
2314415ACGTTGGATGGGCTGAGTAACAGTCCATTGACGTTGGATGCTTACAGTATCCAAAAAGGG
|
6788196ACGTTGGATGTCAAAGGTAGGTTACCCCTGACGTTGGATGATCCCCAATTTGCACATCCC
|
2103062ACGTTGGATGTGCAGCCCTCAACCTTTCAGACGTTGGATGCCTTATTCAGTTACTATTACG
|
9827084ACGTTGGATGAAACACACACACCCACATACACGTTGGATGGGGAGAAAGAAAACAAAGGC
|
9864865ACGTTGGATGCAATGCCTGCACTTAGACACACGTTGGATGAGTGATGAGAACATGGGCTG
|
6804951ACGTTGGATGGCAATAGGACTCCCTTTACCACGTTGGATGAAGATACGAATGGAGCCTGG
|
6770548ACGTTGGATGTTTTTGAGCTTCACTGAGCGACGTTGGATGCGTATCTCTAGCTCAAGCAT
|
1403452ACGTTGGATGCAGAAGTTAGGATGCAGATGACGTTGGATGCCAGTAGAGATAGAATTTTGG
|
7609994ACGTTGGATGATACCTAGAGTTTGCCCAACACGTTGGATGAGCTGAGATCAATCCCTATG
|
9838250ACGTTGGATGGTGGCAGTCAAAACACAGTCACGTTGGATGACAGAGTAAGACTCCGTCTC
|
9863404ACGTTGGATGGCTATTAGAAAGTCAGAGCCACGTTGGATGTGTTCCAGAAGGTGTAGAAG
|
903950ACGTTGGATGCTTCAGTTCAGGGAGAGATCACGTTGGATGATAGGGCCCCCAGCATAAAA
|
6787284ACGTTGGATGGCTTTCCCCTAAAGCATCTCACGTTGGATGGATCTCTCCCTGAACTGAAG
|
2017340ACGTTGGATGTATTCCACTGCCTGCTTTCCACGTTGGATGGAAAACAGGAGGAAGTGGTG
|
2001449ACGTTGGATGATGTCAAGTGCACCCACATGACGTTGGATGAGGAAGAAACTGACGGAAGG
|
1317288ACGTTGGATGATGTCAAGTGCACCCACATGACGTTGGATGAGGAAGAAACTGACGGAAGG
|
7635891ACGTTGGATGTCTCACCTTGCCTTTGGACGACGTTGGATGCTGATGTCGCAAGGAACCAC
|
10704581ACGTTGGATGCCTGTTGAATTATGGAGGAGACGTTGGATGCTCTTCTTTCCATGGATCTTC
|
11371910ACGTTGGATGCTCTTCTTTCCATGGATCTTCACGTTGGATGCAGCTAATTTCTCCTGACAG
|
10937118ACGTTGGATGATGCAAACTGGCTGGGAATGACGTTGGATGGAGGAGGCTGTGAGAAAAGA
|
7642053ACGTTGGATGATGCCCTGGATTGACCTAACACGTTGGATGGGGTTAGGGTGTGTATAAGG
|
3821522ACGTTGGATGAACCCGCACTACAAGATTCCACGTTGGATGGTCAGTCCCACATTCAGAAC
|
2029926ACGTTGGATGTCCCGAACATAAAGACTCAGACGTTGGATGGGTTGTAATTGGAACATTGG
|
1390831ACGTTGGATGGTCTGCCAAAGTTCCCTTAGACGTTGGATGAGGAAAGGGAAGAGAAACCG
|
7643890ACGTTGGATGGACTGTGAGTTATAGGATACACGTTGGATGATGGGTCGGAGGATTTATAG
|
11925606ACGTTGGATGCTCGGCTAAGGTACTCAATAACGTTGGATGAGACCACCAAGTAAAATTGC
|
9826325ACGTTGGATGTTGGGTTAATGCAGGGTCTGACGTTGGATGCTAGTTCACCTGGGTCTATC
|
6800429ACGTTGGATGCCAAAGCCCATGTTTTAAAAAACGTTGGATGGTTTTTCTAAAATATGGGCT
|
6803368ACGTTGGATGAAACCAGCTCAGGCCATTACACGTTGGATGATGCAAAATAAGCTCTGCCC
|
1353566ACGTTGGATGGGTGTACTCTGCCATTTGTCACGTTGGATGTGGAGGAGGTTCTAGTACCC
|
2272115ACGTTGGATGAGTTGTGAGTGATTTCAGGGACGTTGGATGCAGGCCTTCTTGCTCTTATC
|
2272116ACGTTGGATGCTGTGCCTTCTGAGTAGTTCACGTTGGATGATCTGTTGCCTTAGGTTCAC
|
3732603ACGTTGGATGCTCTCAATTCCATCAGTCTCACGTTGGATGCTTTACGAATTTCACAACAGG
|
940055ACGTTGGATGTATGCTTCCAGTCTCTGACCACGTTGGATGATAGGTAATCCAGTTGGGCC
|
2314730ACGTTGGATGCTCAGGTAATCTGCCTTCTCACGTTGGATGCAGGGATAATGAGAACAAATC
|
2030578ACGTTGGATGAACAACCTTACTTCATGCCCACGTTGGATGTTCTCCACTTTCTGGTCAAC
|
2049280ACGTTGGATGTGGATACTGAGGGTCAACTGACGTTGGATGCTTCCCAACATTTTCGGCTC
|
TABLE 22
|
|
|
dbSNP rs#
Extend Primer
Term Mix
|
|
|
3811728
GTCCCCTTTCATCTAAAC
ACT
|
|
3811729
TCTGCAGCGTGCGGCGA
ACT
|
|
602646
CCAGGGTATGAGCGGAGGA
ACT
|
|
488277
AGTGCACACAGAACATTTAACA
ACT
|
|
1629673
TGTGGAGACAAGGTCTCACT
ACT
|
|
670232
TGGGCAAACAAGCCCAT
CGT
|
|
575326
TGGTCATACCCTTCAAG
ACT
|
|
575386
GAAGGGTATGACCAAGC
ACT
|
|
684846
AGTTGTTCAGATCCTCC
ACT
|
|
471365
TCCAAAACCACCAGATAAAATC
ACT
|
|
496251
GTATTGTCCTCCAGTGA
ACG
|
|
831246
AGAATGGTGGTGTATTTTTAC
ACT
|
|
831247
TAGTCCTACACAATCTGTTA
ACT
|
|
KIAA0861-AA
GGTATCAGGAAGAGTCA
ACT
|
|
512071
CCCTGACAATTCCAAAACTAA
ACG
|
|
1502761
GGAGGAGGCACTATTAAT
ACT
|
|
681516
GGCCACCTTCATATTTC
ACG
|
|
683302
CAGGAGATCCAGACCATCC
ACG
|
|
619424
TGCGGCCCCCGCCGGGTT
ACT
|
|
620722
GAATTGCCCGGCTCCGAAT
ACT
|
|
529055
GAGCAGGCAGCACAAGT
ACT
|
|
664010
ACCTCCAGGTAAAATGATTAGTT
ACT
|
|
678454
CAGGGATGGTAATTGAC
ACG
|
|
2653845
AAGCGGAGGTTGCAGTGAGC
ACG
|
|
472795
GACATGTCCCTCTCGGCCT
ACG
|
|
507079
GGCAATGTTTGCCCTTT
ACG
|
|
534333
GGGAGAAAGTAACAGGGTC
ACT
|
|
535298
CAGGTGGATGGGGACAC
ACT
|
|
536213
TGGTGTTAAGTGGCGTG
ACG
|
|
831245
CACACCACCACGCCCGGCT
ACT
|
|
639690
CTGCTATTCATTTGTGTAGA
ACT
|
|
684174
CTCTGATGTTACCTCCTCC
ACT
|
|
571761
CTAGGCTAGCAGTGGGGTTG
ACT
|
|
1983421
GGCAGGGAAGAGAAGAGC
ACT
|
|
4630966
AGATGCCAAGACCATTCAAAG
ACG
|
|
2314415
TAGTTGATGAAGATTTGGG
ACT
|
|
6788196
AGGTTACCCCTGCTGACTTT
ACG
|
|
2103062
GAGATCATTTCTCCTTCAAC
ACT
|
|
9827084
CCACACCCATATATATTTATGCT
ACT
|
|
9864865
AAAGATACACCGTTGAGAAGG
ACT
|
|
6804951
GACTCCCTTTACCTTCATGG
ACG
|
|
6770548
CTTCACTGAGCGTGGTGCC
ACT
|
|
1403452
CACAGATGCTCATGGGTCC
ACT
|
|
7609994
GTTTGCCCAACATATAAACAATAA
CGT
|
|
9838250
AACACAGTCAAAATTTTGCTTCA
ACG
|
|
9863404
GAGCCAAGTTTACATCAAGTTTA
CGT
|
|
903950
AGATCACATTGCCAACCCCCA
CGT
|
|
6787284
CCCGTCTCCTGCTGGTCA
ACG
|
|
2017340
CCCTAAAGCATCTCACAGCCCC
ACT
|
|
2001449
CACATGCCTGCTCGCCCCC
ACT
|
|
1317288
CACATGCCTGCTCGCCCC
ACG
|
|
7635891
TGCCTTTGGACGTCTAGCC
ACT
|
|
10704581
TATGGAGGAGTAGATATTGGAA
CGT
|
|
11371910
GAAAATTCCAATATCTACTCCTC
CGT
|
|
10937118
CTGGGAATGAAATTAGGGCAG
ACT
|
|
7642053
GTTCCCTTGACTTTCCTCAG
ACT
|
|
3821522
GCATCTTCAGGAATCTTG
ACT
|
|
2029926
CATAAAGACTCAGCATTCAGC
ACT
|
|
1390831
GGTTAGGAAGAAATCTGTG
ACT
|
|
7643890
ATCTAGATAATAAAGACCACCAA
ACT
|
|
11925606
CTATTAATGGTGTTTGTCTATGG
ACT
|
|
9826325
TAATGCAGGGTCTGCTGGAT
ACG
|
|
6800429
ATCTCTAAGATATAACACTCTAC
ACG
|
|
6803368
GTGCCTGCAAAGAAAGGAAC
ACT
|
|
1353566
TTGTCAGTTATGAGACCTTG
CGT
|
|
2272115
ATACCTCAGAATACAGCTTTTTTT
ACG
|
|
2272116
TCTCATTTCTCCTCTCTTTC
ACG
|
|
3732603
CTCATTTCCACCCTTCT
ACT
|
|
940055
GTCTCTGACCACTTGACCCA
ACT
|
|
2314730
TCCTTCTTCTCTGCTTT
ACT
|
|
2030578
TCATGCCCATTGGGTTAG
ACT
|
|
2049280
GGGTCAACTGTACCAAG
ACG
|
|
Genetic Analysis of Allelotyping Results
Allelotyping results are shown for cases and controls in Table 23. The allele frequency for the A2 allele is noted in the fifth and sixth columns for breast cancer pools and control pools, respectively, where “AF” is allele frequency. SNPs with blank allele frequencies were untyped (“not AT”).
TABLE 23
|
|
Position inBreast Cancer
SEQ IDChromosomeA1/A2Associated
dbSNP rs#NO: 3PositionAlleleCase AFControl AFp-ValueORAllele
|
|
3811728246184201246T/CT = 0.002T = 0.0030.9521.28C
C = 0.998C = 0.997
3811729393184201393A/GA = 0.968A = 0.9470.2680.61A
G = 0.032G = 0.053
602646628184201628C/GC =C = 0.344
G =G = 0.656
4882777586184208586T/CT = 0.9T = 0.8980.920.98T
C = 0.100C = 0.102
16296739223184210223A/GA = 0.93A = 0.9110.4590.78A
G = 0.070G = 0.089
6702329933184210933A/TA = 0.138A = 0.1370.9510.99A
T = 0.862T = 0.863
57532610154184211154T/CT = 0.876T = 0.8690.7530.94T
C = 0.124C = 0.131
57538610175184211175C/GC = 0.224C = 0.2210.9210.98C
G = 0.776G = 0.779
68484610877184211877T/CT = 0.202T =
C = 0.798C =
47136510907184211907G/CG = 0.258G = 0.2620.881.02C
C = 0.742C = 0.738
49625111289184212289G/AG = 0.841G = 0.8390.9670.99G
A = 0.159A = 0.161
83124611793184212793T/CT = 0.229T = 0.2030.3730.86T
C = 0.771C = 0.797
83124711813184212813G/CG = 0.17G = 0.1780.7551.06C
C = 0.830C = 0.822
KIAA0861-13507184214507C/GC = 0.745C = 0.7620.5571.10G
AAG = 0.255G = 0.238
51207114249184215249C/TC = 0.391C = 0.3630.3760.89C
T = 0.609T = 0.637
150276114586184215586A/CA = 0.417A = 0.4090.7990.97A
C = 0.583C = 0.591
68151614647184215647C/TC = 0.762C = 0.8170.09061.39T
T = 0.238T = 0.183
68330215004184216004C/TC = 0.729C =
T = 0.271T =
61942416573184217573T/GT = 0.925T = 0.9290.8121.06G
G = 0.075G = 0.071
62072216811184217811A/GT =A = 0.181
G =G = 0.819
52905518921184219921A/GA = 0.398A = 0.3640.3250.86A
G = 0.602G = 0.636
66401019651184220651T/GT = 0.549T = 0.6070.1451.27G
G = 0.451G = 0.393
67845420565184221565C/TC = 1.000C = 0.9850.09980.00C
T = 0.000T = 0.015
265384525239184226239G/AG = 0.825G = 0.8270.941.01A
A = 0.175A = 0.173
47279525721184226721G/AG = 0.921G = 0.9210.9830.99G
A = 0.079A = 0.079
50707927133184228133G/AG = 0.166G = 0.1670.9791.00A
A = 0.834A = 0.833
53433327778184228778T/CT = 0.502T = 0.4910.730.96T
C = 0.498C = 0.509
53529827906184228906T/CT = 0.275T = 0.2280.1270.78T
C = 0.725C = 0.772
53621328000184229000G/AG = 0.726G = 0.7170.7810.96G
A = 0.274A = 0.283
83124530005184231005A/GA = 0.979A = 0.9810.8431.12G
G = 0.021G = 0.019
63969030520184231520T/CT = 0.882T = 0.8920.651.10C
C = 0.118C = 0.108
68417432195184233195T/CT = 0.698T = 0.7080.7561.05C
C = 0.302C = 0.292
57176132439184233439C/GC = 0.601C = 0.5760.4990.90C
G = 0.399G = 0.424
198342133858184234858T/CT = 0.566T = 0.580.6691.06C
C = 0.434C = 0.420
463096641716184242716C/TC = 0.359C = 0.2710.002470.66C
T = 0.641T = 0.729
231441542450184243450T/GT = 0.974T = 0.9510.1240.53T
G = 0.026G = 0.049
678819643554184244554G/AG = 1.000G = 1.0000.9670.00G
A = 0A = 0.000
210306244211184245211A/GA = 0.674A = 0.6420.3810.87A
G = 0.326G = 0.358
982708444775184245775G/CG = 0.966G = 0.9280.04030.46G
C = 0.034C = 0.072
986486544962184245962A/GA = 0.106A = 0.1850.0005291.93G
G = 0.894G = 0.815
680495145317184246317C/TC = 0.96C = 0.9040.005730.40C
T = 0.040T = 0.096
677054845712184246712A/GA = 0.062A = 0.1591.12E−052.86G
G = 0.938G = 0.841
140345245941184246941T/CT = 0.97T = 0.9320.01440.43T
C = 0.030C = 0.068
760999446520184247520G/TG = 0.001G = 0.0020.9182.34T
T = 0.999T = 0.998
983825047175184248175C/TC = 0.52C = 0.5240.9091.01T
T = 0.480T = 0.476
986340448045184249045G/TG = 0.001G = 0.0020.8872.58T
T = 0.999T = 0.998
90395048636184249636C/AC = 0.417C = 0.4060.7390.96C
A = 0.583A = 0.594
678728448689184249689G/AG = 0.475G = 0.5010.4161.11A
A = 0.525A = 0.499
201734048704184249704A/GA = 0.965A = 0.9450.1950.63A
G = 0.035G = 0.055
200144948849184249849G/CG = 0.738G = 0.7970.02851.39C
C = 0.262C = 0.203
131728848850184249850G/AG = 1.000G = 1.0000.9670.51G
A = 0.000A = 0.000
763589149931184250931T/GT = 0.973T = 0.9470.1210.49T
G = 0.027G = 0.053
1070458151510184252510—/TT— = 0.998— = 0.9970.9490.83—
TT = 0.002TT = 0.003
1137191051526184252526—/A— = 1.000— = 1.0000.9770.00—
A = 0A = 0.000
1093711851758184252758A/GA = 0.495A = 0.510.6291.06G
G = 0.505G = 0.490
764205351975184252975C/GC = 0.002C = 0.0030.9081.85G
G = 0.998G = 0.997
382152253475184254475A/GA = 0.504A = 0.520.621.07G
G = 0.496G = 0.480
202992655524184256524T/CT = 0.001T = 0.0010.9752.52C
C = 0.999C = 0.999
139083156754184257754T/GT = 0.057T = 0.0760.2841.36G
G = 0.943G = 0.924
764389057473184258473A/GA = 0.001A = 0.0020.9342.30G
G = 0.999G = 0.998
1192560657497184258497A/CA = 0A = 0.0010.956C
C = 1.000C = 0.999
982632557613184258613G/AG = 0.002G = 0.0030.8871.85A
A = 0.998A = 0.997
680042958023184259023G/AG = 0.605G = 0.590.6620.94G
A = 0.395A = 0.410
680336858821184259821T/CT = 0.002T = 0.0010.8850.20T
C = 0.998C = 0.999
135356659644184260644C/AC = 0.452C = 0.4690.6041.07A
A = 0.548A = 0.531
227211566217184267217G/AG = 0.673G = 0.6340.2240.84G
A = 0.327A = 0.366
227211666344184267344G/AG = 0.999G = 1.0000.8768.14A
A = 0.001A = 0.000
373260367326184268326G/CG = 0.773G = 0.7920.4951.11C
C = 0.227C = 0.208
94005569777184270777A/CA = 0.778A = 0.8030.3561.17C
C = 0.222C = 0.197
231473083594184284594A/GA = 0.352A = 0.3110.1830.83A
G = 0.648G = 0.689
203057884579184285579G/CG = 1.000G = 1.0000.9630.33G
C = 0.000C = 0.000
204928085623184286623C/TC = 0.001C = 0.0050.57630.94T
T = 0.999T = 0.995
|
FIG. 1C shows proximal SNPs in and around the KIAA0861 gene for females. As indicated, some of the SNPs were untyped. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIG. 1C can be determined by consulting Table 23. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.
To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10−8 were truncated at that value.
Finally, the gene or genes present in the loci region of the proximal SNPs as annotated by Locus Link (http address: www.ncbi.nlm.nih.gov/LocusLink/) are provided on the graph. The exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.
Additional Genotyping
A total of fourteen SNPs, including the incident SNP, were genotyped in the discovery cohort. The discovery cohort is described in Example 1. Four of the SNPs are non-synonomous, coding SNPs. Two of the SNPs (rs2001449 and rs6804951) were found to be significantly associated with breast cancer with a p-value of 0.001 and 0.007, respectively. See Table 26.
The methods used to verify and genotype the five proximal SNPs of Table 26 are the same methods described in Examples 1 and 2 herein. The PCR primers and extend primers used in these assays are provided in Table 24 and Table 25, respectively.
TABLE 24
|
|
dbSNP #Forward PCR primerRevee PCR primer
|
|
7639705ACGTTGGATGTGTCAGAAAGCAAACCTGGCACGTTGGATGTTACAGGCATTGGAGACAGC
|
2293203ACGTTGGATGCTGCATAATGGTGGCTTTGGACGTTGGATGTGTGGGTGTTCACTTTGCAG
|
3732602ACGTTGGATGCCCTCTTGTCAGGAAGTTCTACGTTGGATGGAGACAGAGTTGAACTCCCG
|
2001449ACGTTGGATGAGGAAGAAACTGACGGAAGGACGTTGGATGATGTCAAGTGCACCCACATG
|
6804951ACGTTGGATGAAGATACGAATGGAGCCTGGACGTTGGATGGCAATAGGACTCCCTTTACC
|
3821522ACGTTGGATGCGCACTACAAGATTCCAAGCACGTTGGATGTCAGTCCCACATTCAGAACC
|
2293203ACGTTGGATGTGTGGGTGTTCACTTTGCAGACGTTGGATGCTGCATAATGGTGGCTTTGG
|
3811729ACGTTGGATGTGGGCGAGGTTCTGCAGCGTACGTTGGATGGTTTCGTTTCTCCGGCACAG
|
534333ACGTTGGATGGATGCACTGAAGGGAGAAAGACGTTGGATGAGAGGCTAAATGTTGGCAGG
|
575326ACGTTGGATGTGAGCCCAAAACTACTGCTGACGTTGGATGATTCCTGCAGGTACTGTGTC
|
2272115ACGTTGGATGCAGGCCTTCTTGCTCTTATCACGTTGGATGAGTTGTGAGTGATTTCAGGG
|
940055ACGTTGGATGTATGCTTCCAGTCTCTGACCACGTTGGATGGATAGGTAATCCAGTTGGGC
|
2017340ACGTTGGATGGATCTCTCCCTGAACTGAAGACGTTGGATGGCTTTCCCCTAAAGCATCTC
|
571761ACGTTGGATGAATATCCTAGGCTAGCAGTGACGTTGGATGGTGCATAAATACATGAATAG
|
TABLE 25
|
|
|
dbSNP #
Extend Primer
Term Mix
|
|
|
7639705
TGATGCACGTGGAGCAG
CGT
|
|
2293203
GCCCCTGGAAAAGGCCC
CGT
|
|
3732602
GGAAGATGATGAGACTAAAT
ACG
|
|
2001449
CACATGCCTGCTCGCCCCC
ACT
|
|
6804951
TCCCTTTACCTTCATGG
ACG
|
|
3821522
GCATCTTCAGGAATCTTG
ACT
|
|
2293203
GCCCCTGGAAAAGGCCC
CGT
|
|
3811729
GGTTCTGCAGCGTGCGGCGA
ACT
|
|
534333
GAAGGGAGAAAGTAACAGGGTC
ACT
|
|
575326
TGGTCATACCCTTCAAG
ACT
|
|
2272115
ATCTTCTACACATTGATTCAG
ACT
|
|
940055
TCTCTGACCACTTGACCCA
ACT
|
|
2017340
TGGTGACCAGCAGGAGA
ACG
|
|
571761
GGCTAGCAGTGGGGTTG
ACT
|
|
Table 26, below, shows the case and control allele frequencies along with the p-values for all of the SNPs genotyped. The disease associated allele of column 4 is in bold and the disease associated amino acid of column 5 is also in bold. The chromosome positions provided correspond to NCBI's Build 34. The amino acid change positions provided in column 5 correspond to KIAA0861 polypeptide sequence of SEQ ID NO: 22. The corresponding amino acid position in the alternative KIAA0861 polypeptide sequence (NP—055893) can be easily calculated by adding 83 amino acids to the positions provided in column 5.
TABLE 26
|
|
Genotyping Results
Breast
Position inAminoCancer
SEQ IDChromosomeAllelesAcidAF FOddsAssociated
dbSNP rs#NO: 3Position(A1/A2)ChangeAF F casecontrolp-valueRatioAllele
|
3811729393184201393A/GA = 0.917A = 0.9480.05421.65G
G = 0.083G = 0.052
57532610154184211154T/CT = 0.897T = 0.8850.5450.88T
C = 0.103C = 0.115
53433327778184228778T/CT = 0.254T = 0.2490.850.97T
C = 0.746C = 0.751
57176132439184233439C/GC = 0.487C = 0.4650.4920.92C
G = 0.513G = 0.535
680495145317184246317C/TA819TC = 0.956C = 0.9150.0072.02C
T = 0.044T = 0.085
201734048704184249704G/AG = 0.027G = 0.0420.2031.57A
A = 0.973A = 0.958
200144948849184249849G/CG = 0.693G = 0.7820.0011.59C
C = 0.307C = 0.218
382152253475184254475A/GA = 0.372A = 0.3910.5391.08G
G = 0.628G = 0.609
227211566217184267217A/GA = 0.407A = 0.4440.2461.16G
G = 0.593G = 0.556
94005569777184270777A/CA = 0.702A = 0.7530.07211.29C
C = 0.298C = 0.247
3732602126831184327831C/TS506FC = 0.008C = 0.0120.5971.41T
T = 0.992T = 0.988
2293203137878184338878A/TL295QA = 0.012A = 0.0150.6901.24T
T = 0.988T = 0.985
7639705147455184348455G/TI276LG = 0.195G = 0.1890.7941.04G
T = 0.805T = 0.811
|
Example 7
NUMA1 Region Proximal SNPs
It has been discovered that a polymorphic variation (rs673478) in the NUMA1/FLJ20625/LOC220074 region is associated with the occurrence of breast cancer (see Examples 1 and 2). Subsequently, SNPs proximal to the incident SNP (rs673478) were identified and allelotyped in breast cancer sample sets and control sample sets as described in Examples 1 and 2. Approximately 327 allelic variants located within the NUMA1/FLJ20625/LOC220074 region were identified and allelotyped. The polymorphic variants are set forth in Table 27. The chromosome position provided in column four of Table 27 is based on Genome “Build 34” of NCBI's GenBank.
TABLE 27
|
|
Position inChromosomeAlleleGenomeDeduced
dbSNP rs#SEQ ID NO: 4ChromosomePositionVariantsLetterIupac
|
|
49453922031171420953t/ccY
793849612361171421986g/aaR
792655017681171422518c/ggS
794537421011171422851a/ttW
794948031461171423896t/ctY
710252344761171425226t/ctY
712126061241171426874a/ggR
713123067191171427469c/ttY
712831769251171427675g/aaR
227638570601171427810c/ggS
227638470811171427831t/cgR
227638370901171427840a/gcY
189292176961171428446c/tgR
189292079891171428739c/taR
794262694071171430157g/agR
712442996991171430449t/ggK
711408199051171430655a/ttW
712571899841171430734c/tcY
1055452130231171433773t/ctY
3829215130471171433797g/atY
1541306135711171434321c/tgR
3814722140861171434836c/agK
1939240143371171435087t/atW
5743655144621171435212t/ccY
5743656145181171435268a/ggR
5743657146951171435445a/ggR
3814721148301171435580g/acY
5743658152821171436032c/aaM
5743659154361171436186a/ggR
5743660157451171436495g/agR
5743661157481171436498g/tgK
5743662157971171436547t/ctY
2298455160361171436786t/gaM
5743664166461171437396g/agR
5743665167131171437463a/gaR
5743667168591171437609g/agR
5743668169141171437664g/—cN
5743669174221171438172c/tcY
1573503174991171438249a/gtY
5743670176461171438396g/ccS
5743671176811171438431g/agR
1892919177331171438483c/tgR
5743672178411171438591g/agR
2735786179631171438713a/ggR
5743673180111171438761g/agR
5743674182381171438988a/taW
1062452185691171439319c/acM
5743675186721171439422t/ccY
5743676187151171439465a/ggR
760246189271171439677c/ttY
11345794192661171440016t/—tN
5743677192901171440040c/tcY
5743678194561171440206t/gtK
14537195111171440261c/tgR
3168177195751171440325g/acY
5743679195911171440341g/agR
1541304196361171440386g/atY
1053725197701171440520a/gcY
5743680200021171440752g/aaR
949324200841171440834g/cgS
949323200861171440836a/ctK
5743681202461171440996t/ccY
5743682202531171441003t/ctY
5743683203001171441050g/agR
5743684205391171441289g/agR
5743685206821171441432c/tcY
2845857207731171441523g/ccS
2852365207761171441526g/atY
11538641209041171441654c/agK
11538639209181171441668c/tgR
11235417209781171441728a/ggR
11538644212691171442019c/agK
11538643213541171442104c/tgR
2845858214881171442238t/ccY
2155146216561171442406g/taM
2852364217931171442543t/cgR
2845859220841171442834a/gaR
2845860222191171442969t/ccY
11538642228151171443565g/tcM
7949430228581171443608t/ccY
7938674228951171443645t/ctY
2735787234311171444181c/ttY
11538640239681171444718c/taR
10736784244691171445219t/atW
10736785244701171445220a/ccM
11826059248531171445603t/ctY
2503249611171445711t/ctY
2155145251771171445927a/cgK
4477459261741171446924t/ctY
NUMA1-AA263341171447084t/—tN
5019605263371171447087c/gcS
5019604263381171447088a/ttW
5019603263391171447089c/gcS
3793941269651171447715g/acY
11235418272781171448028c/gcS
3793940280421171448792a/gcY
2032353285201171449270g/tcM
3934448285331171449283g/tcM
7951267287641171449514a/ggR
1053603296851171450435g/acY
1053602307381171451488a/gcY
11235419311751171451925t/ccY
1053601314901171452240a/gcY
3750913317261171452476g/cgS
3750912317701171452520a/gcY
1053600317921171452542t/atW
1057992329801171453730c/aaM
2298789333981171454148a/gtY
10898813335801171454330t/atW
1127871234468-344721171455218{circumflex over ( )}—/gtcaacgtcaacNNNNN
71455222
NUMA1-AB349411171455691c/ttY
949325352141171455964g/aaR
NUMA1-AC356291171456379g/ccS
949326358641171456614t/ccY
2298456362731171457023a/ttW
7949845372811171458031a/gaR
7949989373781171458128a/gaR
1573500383481171459098c/gcS
4945411386081171459358a/ggR
383138738627-386281171459377{circumflex over ( )}ca/—caNN
71459378
11235422390491171459799c/acM
10128658390771171459827c/tcY
2298457397691171460519t/ctY
3838779405551171461305t/—cN
1573501412511171462001t/ccY
11235424412701171462020c/tcY
10898814420631171462813t/ctY
7930142425741171463324t/ccY
7930544429121171463662c/tcY
7930721430391171463789a/ccM
7930722430421171463792c/gcS
6592456432211171463971a/ggR
11235425435181171464268t/ccY
6592457436441171464394g/cgS
10898815449811171465731a/ggR
11235426450131171465763t/ccY
10898816450381171465788c/tcY
1939247460791171466829t/aaW
1939246478481171468598t/gaM
1939245480901171468840a/gcY
1939244481471171468897g/tcM
1939243482931171469043c/tgR
4245463487711171469521c/acM
4944258489511171469701a/ttW
7926751499721171470722t/gtK
12282917501611171470911g/agR
12282918501631171470913g/agR
7937582501711171470921t/ccY
10898817512891171472039t/ccY
7480015516991171472449g/aaR
7123992520051171472755c/tcY
1573502529861171473736g/acY
7127865533391171474089g/cgS
4945426537041171474454c/acM
11235428546151171475365g/cgS
7122489553071171476057a/caM
1894003558341171476584t/caR
1548348564751171477225g/aaR
1892923570531171477803g/acY
5792570573551171478105—/ggN
7115200577181171478468t/gtK
4945430587031171479453g/cgS
11235429587721171479522c/ttY
1939242591401171479890c/tgR
9666346594501171480200g/ccS
7101553594611171480211t/ccY
7124000598961171480646c/ttY
12291664601571171480907g/agR
12291778603691171481119a/ggR
12291781603951171481145a/ggR
12291787604241171481174g/agR
12291788604261171481176g/agR
12291833604561171481206a/ggR
10793016606211171481371g/agR
5792571612071171481957g/—gN
12293529612091171481959g/cgS
4338555612541171482004c/ttY
11235431618541171482604c/ggS
6592458631031171483853a/ggR
4945434646451171485395c/tcY
4945435647771171485527t/ccY
11307657649801171485730t/—tN
5792573649871171485737t/—tN
1894004653751171486125t/cgR
12276164655611171486311a/ggR
4378421675541171488304c/ttY
7116495676431171488393c/tcY
7101701677131171488463a/gaR
10736786688321171489582t/ccY
11608165701841171490934t/gtK
645603704151171491165g/aaR
661290715721171492322a/gaR
7122209717321171492482t/ctY
12417471728291171493579a/gaR
541228731541171493904c/gcS
12273666732211171493971a/gaR
2511074743431171495093t/cgR
3018311744621171495212t/ggK
3018289744711171495221t/ctY
679926754941171496244a/gcY
567026755101171496260g/atY
564294758271171496577g/atY
678193758311171496581t/gaM
677279760271171496777t/cgR
560777761601171496910c/taR
676721761961171496946c/tgR
7106529763781171497128a/taW
11602304773061171498056g/agR
585228788471171499597c/ggS
578957789181171499668c/aaM
7110215791171171499867a/ggR
3133233798111171500561c/ggS
3133230798431171500593t/ccY
12576024804481171501198g/tgK
674319809491171501699c/ttY
675185811301171501880t/gtK
5792574814521171502202—/caN
12275272825951171503345c/tcY
10400327836331171504383c/ttY
612255842221171504972c/taR
7101643843781171505128g/agR
575871843801171505130a/gtY
547208852261171505976c/taR
2511075858151171506565t/ctY
642573864121171507162c/ggS
482197868051171507555g/aaR
656640872681171508018t/ctY
671681883701171509120c/ttY
541022886141171509364a/ggR
951586892231171509973a/gcY
2511076893851171510135g/aaR
11235432895001171510250g/cgS
3018308895021171510252t/ctY
11606798899291171510679g/cgS
1791544905151171511265c/tgR
3018304906591171511409c/atK
10751193909141171511664a/caM
4945470915941171512344c/ttY
3018291916031171512353a/caM
2511120917691171512519a/gcY
671132920051171512755g/acY
4945475933351171514085g/cgS
3018292934431171514193t/gtK
642618937511171514501c/tgR
552966937751171514525a/caM
6592459943511171515101t/ggK
607446948101171515560c/tgR
607070948561171515606a/gcY
10713307958931171516643c/—cN
3018302965001171517250t/gaM
3750909975871171518337g/cgS
3018301976291171518379a/gaR
2511114977051171518455c/ttY
12270166979671171518717a/ggR
12270241981261171518876g/agR
11606587984221171519172a/gaR
686340987701171519520g/ccS
548961994451171520195g/agR
549032994671171520217c/aaM
5758311001041171520854a/gaR
5758781001211171520871a/ttW
5774351002391171520989t/ccY
5793201005121171521262g/tgK
4955671010461171521796c/tcY
6369461012671171522017c/ttY
4930651024871171523237a/gtY
5975131029801171523730a/ttW
5988351032851171524035t/ccY
106836141033591171524109—/tagttN
6100041034971171524247t/ccY
6100411035261171524276a/gaR
6734781046621171525412t/cgR
6708021052261171525976t/gaM
5050411059501171526700t/atW
25111161077181171528468c/tgR
6280251079091171528659a/caM
5178371079171171528667c/taR
6150001085101171529260t/gaM
4820131095201171530270c/tgR
6933911096761171530426t/gcM
25110791097121171530462t/ccY
22508661100711171530821t/cgR
25088601106101171531360a/gcY
74832671107571171531507a/ggR
25110781107581171531508g/acY
25088591109231171531673t/gaM
25088581109631171531713c/gcS
112354351112451171531995t/ggK
112354361114371171532187a/ggR
6394351121741171532924a/ctK
122856241126461171533396a/gaR
NUMA1-AD1127841171533534g/ttK
6243631132751171534025t/cgR
NUMA1-AE1136141171534364t/ctY
10535731139651171534715g/taM
10535111140951171534845c/tgR
10638631141251171534875g/acY
121371142131171534963c/tcY
43650811142781171535028a/ggR
44668681143211171535071g/cgS
37509111144651171535215a/ggR
5109251150581171535808t/ccY
5950621151931171535943a/gcY
10534431154331171536183c/tgR
5427521162021171536952a/ttW
38975791163281171537078t/cgR
112354371168121171537562t/ccY
25088561172011171537951c/tgR
57925751175651171538315a/—aN
6595131179691171538719g/agR
108988201181501171538900a/ggR
22763971277291171548479c/taR
37509081279591171548709c/taR
37939381286911171549441c/tgR
6022851290861171549836c/ggS
22763961294631171550213g/cgS
22763951299001171550650t/cgR
18067781366101171557360t/caR
40733941377971171558547a/gaR
4715471517371171572487g/tgK
6061361521301171572880a/gcY
6052411523321171573082t/cgR
6860631537891171574539g/atY
6857491538131171574563t/cgR
5332071538441171574594a/caM
4767531886121171609362a/ggR
NUMA1-AF1911491171611899g/tgK
|
Assay for Verifving and Allelotyping SNPs
The methods used to verify and allelotype the proximal SNPs of Table 27 are the same methods described in Examples 1 and 2 herein. The PCR primers and extend primers used in these assays are provided in Table 28 and Table 29, respectively.
TABLE 28
|
|
dbSNP rs#Forward PCR primerReverse PCR primer
|
|
4945392ACGTTGGATGGGCACACAGTAGGTGCTTATACGTTGGATGCCACCAGCTTGTGAGGTAAT
|
7938496ACGTTGGATGTGCAGTGAACTGCACTCCAGACGTTGGATGCTGGCCAGTAACTACTAGCT
|
7926550ACGTTGGATGTTACTGAGTTTCCTAGGCTGACGTTGGATGGAATCCCAACACTTTGGGAG
|
7945374ACGTTGGATGGAACACACACAGCTCTATTCACGTTGGATGCACATCCTTTTCACCGTGTC
|
7949480ACGTTGGATGGGTTTCACCATATTGGCCAGACGTTGGATGCACGCCTATAATCCAAACAC
|
7102523ACGTTGGATGAAACTGGATGTGTTCCTGGGACG1TGGATGGTAGACTCAGAGCTTAGGTG
|
7121260ACGTTGGATGGCTACTGATCAAATTAAGTGGACGTTGGATGGCTGCATTTGCTTATGAACC
|
7131230ACGTTGGATGAGACAATCTCAGAAAGAGGGACGTTGGATGATCCATAAGGAGGAAAGGGC
|
7128317ACGTTGGATGAGACCAAGCTACAGTATCCCACGTTGGATGGGTAGCTGCAAGTCATTGTC
|
2276385ACGTTGGATGAAGTGCGGGCAAACTATGACACGTTGGATGTCCTCAAGAGGTGTTCATGG
|
2276384ACGTTGGATGAGACAGCAGACTGGATTTGGACGTTGGATGACTACTCTGGGACACACAAG
|
2276383ACGTTGGATGACTACTCTGGGACACACAAGACGTTGGATGTTTGGTCATAGTTTGCCCGC
|
1892921ACGTTGGATGCCTGTTGCCCATGTAATGAGACGTTGGATGTACAAGAGGAGGAGGGAGTG
|
1892920ACGTTGGATGAGTTTATCTGGGCAAAAACCACGTTGGATGAATGCCTGCTATGTGTCTAG
|
7942626ACGTTGGATGGAAATATTTACTTGCGTTTCTCACGTTGGATGTGGACATCACGGAGAGATGC
|
7124429ACGTTGGATGCTGGATCAAATTGAAAACAGACGTTGGATGGAAGGTAAAGCACAAGACAG
|
7114081ACGTTGGATGTGGGCAGAGTTTCTGTTTGGACGTTGGATGGCATTAATTACATTTGCAGTG
|
7125718ACGTTGGATGTCCCAAACAGAAACTCTGCCACGTTGGATGAGGCATGTTCACAGAGATGG
|
1055452ACGTTGGATGATCATATCCCTCCCCAGTCCACGTTGGATGAAGACCTCCTGGGTGGGAAA
|
3829215ACGTTGGATGTGGGTGGGAAAGACTCAAAGACGTTGGATGTCCATCATATCCCTCCCCAG
|
1541306ACGTTGGATGCTGATTCTTCCAGTTGTCCCACGTTGGATGACCTTATCAGTGACTTGGCC
|
3814722ACGTTGGATGATCCTGCTTCGTTCTTGCTGACGTTGGATGAAGTGGGAGGTCAAACATGG
|
1939240ACGTTGGATGATTCCACCACTCCTAGGGATACGTTGGATGTTAACCCCCATCGGAGACCT
|
5743655ACGTTGGATGTGAGTGTGGTCCTCAGGAAGACGTTGGATGCAGACTGAGGTTGCTCTATG
|
5743656ACGTTGGATGACTCAGGCTCGGCTTCTCTTACGTTGGATGACAGGTGGCATAAGCAGCAG
|
5743657ACGTTGGATGTGTCAGGCTCAGGTGAGAAGACGTTGGATGGAGGTCAAGGGACTCAGAAC
|
3814721ACGTTGGATGGACTGTCTCTCTCAGAAACCACGTTGGATGATTCCTCCCAAGAACACCAG
|
5743658ACGTTGGATGCCTCCTTAGATTTAGCATCCACGTTGGATGTCACTGATGGGACAAATGGC
|
5743659ACGTTGGATGTTGCCAGAGCCAGTGTTGAGACGTTGGATGAGGAACTGGCACACAAGCTC
|
5743660ACGTTGGATGTTCAGGCTCAATGCCATACCACGTTGGATGTGGGAGATGTAGCCGACCTT
|
5743661ACGTTGGATGTTCAGGCTCAATGCCATACCACGTTGGATGTGGGAGATGTAGCCGACCTT
|
5743662ACGTTGGATGGACAACTTTCCTAGGCACTGACGTTGGATGAAAGGCCAGGATGTGGACGG
|
2298455ACGTTGGATGTCCTACTCTCCAGAGGATACACGTTGGATGAGTTCATACCCTAGGTGACC
|
5743664ACGTTGGATGCCCATTGCTCCATTCTGTTCACGTTGGATGCATGAGACACAACTGGACAC
|
5743665ACGTTGGATGGAATGGAGCAATGGGCTAACACGTTGGATGGCCCAGGTTCTTAAAGCAAC
|
5743667ACGTTGGATGTAAGGATGTAACTCCAGCCCACGTTGGATGGTTCAATAAAGGGCTAAGGG
|
5743668ACGTTGGATGGAGGAAAGGACAGTTACAGGACGTTGGATGGGCTGGAGTTACATCCTTAC
|
5743669ACGTTGGATGAGTAATGGTCACAGGACCTCACGTTGGATGTGCTCCTCTGAGATGGCCAG
|
1573503ACGTTGGATGGATGACCTTTTCTAGTGCCCACGTTGGATGTCAGAGGAGCAGCAGCCATC
|
5743670ACGTTGGATGTAGAGAACTGCTCTGCACACACGTTGGATGCTCACATTCCCCGTGTTTAG
|
5743671ACGTTGGATGCATGCATCTGGAACCTAGAGACGTTGGATGACTGCACTTCTGTAACGGAC
|
1892919ACGTTGGATGTAGCTCTTCAGAAGAGCAGGACGTTGGATGGTTCTCTAGGTTCCAGATGC
|
5743672ACGTTGGATGATGAAGGAACCATTGCCCAGACGTTGGATGATGGAACGCTGAGCTTATCC
|
2735786ACGTTGGATGAGCACCAGGTGAGGGTCGCAACGTTGGATGAGGGAAGGAAAGGTCATGAG
|
5743673ACGTTGGATGAGCACCAAGGCCTTGCACAGACGTTGGATGTCTCATGACCTTTCCTTCCC
|
5743674ACGTTGGATGTGAGGAATGCTGGGCATTAGACGTTGGATGGAGCTCTGCTTCCATATGTG
|
1062452ACGTTGGATGTGTCTACCTGGAGTGAACAGACGTTGGATGGACCCAAAGCAGAGAAGGAG
|
5743675ACGTTGGATGGATAGGTGGAGAGAGAATGGACGTTGGATGCAAACTCCATTCCCACCTAC
|
5743676ACGTTGGATGCATTCTCTCTCCACCTATCCACGTTGGATGAGTCTTGGTGGTTTCTGAGC
|
760246ACGTTGGATGTTTAGTCCCGTCTTCCTCACACGTTGGATGGATGACTTCACTGAAGAGGC
|
11345794ACGTTGGATGCAGAAGCTGAAGACAACACCACGTTGGATGGAGCATTATGGGCTGTTCTC
|
5743677ACGTTGGATGAACACAGGCGCTTGAAAAAGACGTTGGATGCTCTTCCCACTCTCCATTAG
|
5743678ACGTTGGATGACTCAGCAGGAACAAGGTAGACGTTGGATGCTATTTTTCTCCCGTGAGTAC
|
14537ACGTTGGATGTGGGAAGGTTTTTAAGGGCCACGTTGGATGAGTCAACTCAGTACTCACGG
|
3168177ACGTTGGATGCCTTCCCATCACTCCAAATCACGTTGGATGACAGCCTTCAGCAGCAGCTC
|
5743679ACGTTGGATGATGGGCCCTATGTCTCAGGAACGTTGGATGAAATCCCACCCCAGTGCAAG
|
1541304ACGTTGGATGAAGGTAGGGTGTGAGCTGCTGACGTTGGATGAGGATGCTCTTTCCCAGGAC
|
1053725ACGTTGGATGTAGCCTCTGGATCTAGAAGGACGTTGGATGTCCTGGACTTCAAGAGTGAG
|
5743680ACGTTGGATGAACAGTAGCCAAACCCCTAGACGTTGGATGAGAAGGCGCCAGTGAAGGAC
|
949324ACGTTGGATGTGAGAGAAGGCACTGAGAGGACGTTGGATGAAGCACTAAAGGGCCAGTAC
|
949323ACGTTGGATGTGAGAGAAGGCACTGAGAGGACGTTGGATGAAGCACTAAAGGGCCAGTAC
|
5743681ACGTTGGATGACAGCCAGCAACTGATAACCACGTTGGATGCTGGGAAGATCTCTTCCTGC
|
5743682ACGTTGGATGACAGCCAGCAACTGATAACCACGTTGGATGCTGGGAAGATCTCTTCCTGC
|
5743683ACGTTGGATGTCTCCAAGGAGAGAAGACAGACGTTGGATGTTATCAGTTGCTGGCTGTGC
|
5743684ACGTTGGATGTTCTCCGCGCATTGCCACCAACGTTGGATGAGTGCCTCTACCTTGCCCTT
|
5743685ACGTTGGATGCTAGCTTCTTGGGTGTGTTGACGTTGGATGTCTGACAGCCCTTCCTTGCA
|
2845857ACGTTGGATGTACTAAACAGGTGAGGCTGGACGTTGGATGTTCCCAGGCCAGCGTGCTGT
|
2852365ACGTTGGATGTTCCCAGGCCAGCGTGCTGTACGTTGGATGTACTAAACAGGTGAGGCTGG
|
11538641ACGTTGGATGACTCCTGAGTCTAAGAAGGCACGTTGGATGTCAGTAGTGCTCTGTTTGCG
|
11538639ACGTTGGATGACTCCTGAGTCTAAGAAGGCACGTTGGATGTCTGTTTGCGCCCTTCATGT
|
11235417ACGTTGGATGGGTGGCCTTCTTAGACTATGACGTTGGATGAAGACACCTGGCTTCAGATG
|
11538644ACGTTGGATGAGCAGCGCAAACGGGTCTCACGTTGGATGGGAAACAGCTGGTGGCCTTC
|
11538643ACGTTGGATGCCATCACAGATGAGGAGATGACGTTGGATGCTATCTGGATTGGCTGCATG
|
2845858ACGTTGGATGAAGGGTCCCGACCATAAGTGACGTTGGATGTAGCTGTATGGAGATGGAGG
|
2155146ACGTTGGATGGATTCCTCTCTGAGCTCCTGACGTTGGATGTGTTTCCAGGTGGAACAGAC
|
2852364ACGTTGGATGCTAGATCAGCAGGTGGGATTACGTTGGATGTGAAGACCTGCTATCCCCTG
|
2845859ACGTTGGATGCCACCTACCCCATAAACTTGACGTTGGATGATAGTCTGTGTGCCGTACTC
|
2845860ACGTTGGATGCCCGGTCCTTAATTTGTTCCACGTTGGATGCACGCAGAGACTGCTACTAC
|
11538642ACGTTGGATGAGGCTAGCCTGGGAAGCAGGAACGTTGGATGGCTAGATGTGGAAGAGCCAG
|
7949430ACGTTGGATGGTACACTGCAACAGATTCACACGTTGGATGGCTGTAGAACGATGAGTTGG
|
7938674ACGTTGGATGAAGGGAATGGGAAGCTTCTGACGTTGGATGCTAGCTTCTGGAAGACAGAG
|
2735787ACGTTGGATGCAAACCTCCCCTTCAAGATGACGTTGGATGATTGTTGCTGCCCAGTGGAC
|
11538640ACGTTGGATGAACCAGCCTCACCTATCTCCACGTTGGATGCAGGGATGGGAGTGAAGTAG
|
10736784ACGTTGGATGATCCAATGTCGTCCTGCTTGACGTTGGATGAAGGACATGAGCATGGAGTG
|
10736785ACGTTGGATGAAGGACATGAGCATGGAGTGACGTTGGATGATCCAATGTCGTCCTGCTTG
|
11826059ACGTTGGATGAGGAACCTTGGAAGAATTTGACGTTGGATGGTCTTAACTTCTATACTAGC
|
2503ACGTTGGATGACTAAGCTGAGATGTGAGGCACGTTGGATGCACCAAGGTTTCCTCAATGC
|
2155145ACGTTGGATGGATATCTGGTATAATACCCGACGTTGGATGTCAGGCTGTATCCTAGTGAG
|
4477459ACGTTGGATGAGAAGGCAAAGATAGGGCAGACGTTGGATGCGACTACAGTCTACTAAACC
|
NUMA1-AAACGTTGGATGAAGTTCCCCTGTCCTAAGAGACGTTGGATGAACCAATCCTCAGGGAACAC
|
5019605ACGTTGGATGTAGGAGGAAGGGAACCAATCACGTTGGATGAAGAGAGCTCACATGCCAAG
|
5019604ACGTTGGATGAAGTTCCCCTGTCCTAAGAGACGTTGGATGAACCAATCCTCAGGGAACAC
|
5019603ACGTTGGATGAACCAATCCTCAGGGAACACACGTTGGATGAAGTTCCCCTGTCCTAAGAG
|
3793941ACGTTGGATGAAGGTGACACAGTTGAAAGCACGTTGGATGTCTAGATAGTCTGGGCAGGG
|
11235418ACGTTGGATGTCTAAGCCACAGGCTTCCTAACGTTGGATGGCTATTCTCTAAGCTCTGGG
|
3793940ACGTTGGATGTCTCTCTTTTCCCCTACTCCACGTTGGATGGCAGCACATGTACTCCAAAG
|
2032353ACGTTGGATGTAGAGCCCCAGAAAGTGATGACGTTGGATGCTTGAAGGTGATATGCGAGG
|
3934448ACGTTGGATGTAGAGCCCCAGAAAGTGATGACGTTGGATGCTTGAAGGTGATATGCGAGG
|
7951267ACGTTGGATGATTGGTTCAGGGTGGGAAAGACGTTGGATGACCCTTCTGCACCTTCTCTC
|
1053603ACGTTGGATGGTCTCAGCATCAGCACGTACACGTTGGATGGTTTCTGGAAGTGGAGTTGG
|
1053602ACGTTGGATGTGGCAGGACAGAGCCAACAGACGTTGGATGTGCTGCTTCTGGCATTGCTG
|
11235419ACGTTGGATGAGGCAGCGCTGCAGGCTATGACGTTGGATGGCCCGCAGCCGTTCCAGCT
|
1053601ACGTTGGATGCACAGCGAGCTCCAGATAAGACGTTGGATGACTTCCTTCTCTTGGACCTG
|
3750913ACGTTGGATGCACACTCACTCTCAGCTGTGACGTTGGATGCCATCAGGCTGAGACTGAAG
|
3750912ACGTTGGATGCTCGATTACAGCAGCTTGGGACGTTGGATGTCACTCTCAGCTGTGTGCTGG
|
1053600ACGTTGGATGAAGGAGCTGGAAGAAGAGAGACGTTGGATGACTTCAGTCTCAGCCTGATG
|
1057992ACGTTGGATGGAACACCAGGAACCCAAATGACGTTGGATGTTGCAGGTAGGAATGCACAG
|
2298789ACGTTGGATGCAAGACTTATCTGAGGAAGGACGTTGGATGAACCTGCTTACTACTTCCCC
|
10898813ACGTTGGATGGCACCTACAATAGGCTATGCACGTTGGATGTAGAGCGAGACTCTGTCTCA
|
11278712ACGTTGGATGGGCAAGTGAGAATCCCCATCACGTTGGATGATAATTGGAGGCATCCAGCC
|
NUMA1-ABACGTTGGATGGGGAAGCAGTGAGAAGAGAGACGTTGGATGAGCTCTCCCTGCATTCCTTC
|
949325ACGTTGGATGTGTCCCCATCTTCTCTTTCCACGTTGGATGCAGAACTATGTGCACAAGGG
|
NUMA1-ACACGTTGGATGTAGTGCGCACTTCCATAGACACGTTGGATGCATATGCATTGGTAAGCGCC
|
949326ACGTTGGATGCCCTCAAAAGCTGTTCCCTGACGTTGGATGCTGCAGAGATGTGCTAAGAG
|
2298456ACGTTGGATGGTTCTCAAATTGCATAAAGGACGTTGGATGTAGAAGGCACAGGAGCTGGG
|
7949845ACGTTGGATGTCACCTGATGTCAGGAGTTCACGTTGGATGCCACCACACCTGGCTAATTT
|
7949989ACGTTGGATGAAATTAGCCAGGTGTGGTGGACGTTGGATGAATCTCCACTTCCCGTGTTC
|
1573500ACGTTGGATGCTATAACCTCCAACTCCTGGACGTTGGATGAAAAATGAGCTGGGTGTGGC
|
4945411ACGTTGGATGGAGGAAAGGATGAGATAAATGACGTTGGATGCTCTGTTCCTATATGTGTTTC
|
3831387ACGTTGGATGATGAAGTGAAAGTTCTGTGGACGTTGGATGCGTAGAAATTATTCTCTGTTCC
|
11235422ACGTTGGATGTCTAGAAGCCAAACAGGAGGACGTTGGATGAAGAGTCACCGGAATAGCTC
|
10128658ACGTTGGATGTCTAGAAGCCAAACAGGAGGACGTTGGATGAAGAGTCACCGGAATAGCTC
|
2298457ACGTTGGATGTGGTTTCCAGGAAGTTCACCACGTTGGATGTGTGCAGATACCAGGCATTC
|
3838779ACGTTGGATGCTGTTTCCCCGAACTTCAAGACGTTGGATGCTTGCAAGGGAAAGAGACTC
|
1573501ACGTTGGATGTAGCTTCCCGTTCATCTGTGACGTTGGATGCTGCCACCCTATTTGCAAAC
|
11235424ACGTTGGATGCTGCCACCCTATTTGCAAACACGTTGGATGTTGAGCCATTCCAGATGGTG
|
10898814ACGTTGGATGTGGAACTGCAGTTAGCTAGGACGTTGGATGAATACTAGTCCCTGGGATCC
|
7930142ACGTTGGATGACATTTCACCTGAGAACCTCACGTTGGATGATGTTGTGACTCCTTGGCTC
|
7930544ACGTTGGATGGCAGCACTCATGAATGCAACACGTTGGATGGCACCTACTTTATTCCTGGC
|
7930721ACGTTGGATGTAGTGGAGGCATTTTGCCAGACGTTGGATGGAGGGATGCTTTTTACTGAG
|
7930722ACGTTGGATGGAGGGATGCTTTTTACTGAGACGTTGGATGTAGTGGAGGCATTTTGCCAG
|
6592456ACGTTGGATGAAGGGAAACTTGTCAGAGGGACGTTGGATGATAAGCTGTGGGAGTTGAGG
|
11235425ACGTTGGATGCTTGGAGGTAGGCGATATTGACGTTGGATGAAGGAAGCTGGTCTGCATTG
|
6592457ACGTTGGATGGTGTGTTGTCCTTGGGTTAGACGTTGGATGGCATCTTGAATTTTTGGCCC
|
10898815ACGTTGGATGTGAGTCCCTGATACCAGTTCACGTTGGATGAGGCCAAGGATAGACTGAAG
|
11235426ACGTTGGATGTTAGATTGTTTGCCCCAGGCACGTTGGATGTGATACCAGTTCCTAACTGC
|
10898816ACGTTGGATGTTCAGTCTATCCTTGGCCTGACGTTGGATGCCAAGCATAGGTCAGTTGTC
|
1939247ACGTTGGATGAAAGGAAGGGCTCTCTGATGACGTTGGATGTAATTTCAGGAAGGAGTGCC
|
1939246ACGTTGGATGCACAGTGCAGGGACACTATCACGTTGGATGATAAGAGGCTGAGGTAGGTG
|
1939245ACGTTGGATGTGCGCCTGGCCTAAAAGTTGACGTTGGATGTCAATGATTTCTCTACAGAC
|
1939244ACGTTGGATGAACAACTTTTAGGCCAGGCGACGTTGGATGTCAAGCAGTCCTTCCACCTC
|
1939243ACGTTGGATGCTCAAGCGATCTTCCCACGTACGTTGGATGTTTTTAGCTGGGTGAGGTGG
|
4245463ACGTTGGATGTGAAGCTGCAACTGCATTCCACGTTGGATGCTGTTTTAACTGGGATTCATC
|
4944258ACGTTGGATGGTCTCTTCATTTTCTGCAGGACGTTGGATGTTGGTCAGGACAGGTCATTG
|
7926751ACGTTGGATGCTGATCCCAGCACATATAACACGTTGGATGATAGAGTGAAAGCCTGTGTC
|
12282917ACGTTGGATGTCAGAAGTTTGCAACCACCCACGTTGGATGCCACCACACCCAGCTAATTT
|
12282918ACGTTGGATGTCAGAAGTTTGCAACCACCCACGTTGGATGCCACCACACCCAGCTAATTT
|
7937582ACGTTGGATGGAGCTCAGAAGTTTGCAACCACGTTGGATGCCACACCCAGCTAATTTTTG
|
10898817ACGTTGGATGTCTCTGACCCAGGGCAAGTTACGTTGGATGTTGCAGTGAGCCGAGATCAC
|
7480015ACGTTGGATGTAATCCCAGCACTTTGGGAGACGTTGGATGACAGGTTTTTGCCATGTTGC
|
7123992ACGTTGGATGGACCAAAGTCCCTGCATATGACGTTGGATGCAGAGCAAGACTCGGTCTAA
|
1573502ACGTTGGATGTGCTGATTTAATGTGACCAGACGTTGGATGCATTTTTGCAGATAAAGAAA
|
7127865ACGTTGGATGAGGTGGCAGAATCTCAATGGACGTTGGATGGGAGATCCCATGGGACATTT
|
4945426ACGTTGGATGACACCATTCTTGCCCAGAAGACGTTGGATGTGGATAGGAAGGACCAAGAG
|
11235428ACGTTGGATGAGAAACCCCAGTTGAGTGTCACGTTGGATGGCTGACAAGACTAAAGCTCG
|
7122489ACGTTGGATGTCTCAGCAGATCCTTCTGTGACGTTGGATGAGTACACTGGGTGATGCTGA
|
1894003ACGTTGGATGGCCTAGCCATGATTTCCTACACGTTGGATGTTGACCCTCTGGTCCTGC
|
1548348ACGTTGGATGTCGGTGTTTGCTTGCATGTGACGTTGGATGGTGAAAACCCTGATCTTGGG
|
1892923ACGTTGGATGTGCAGCCATGTATTGTACTGACGTTGGATGTGTGTGAATATAGTGGTGGG
|
5792570ACGTTGGATGGAAAGCAACCCTTTGCTCTGACGTTGGATGATACTCAGAAACAGGCGCTG
|
7115200ACGTTGGATGTTGGTTTTCTTCTCAGTCTGACGTTGGATGAAAGAAAGCAGACTCCTGGC
|
4945430ACGTTGGATGCAGCCATGTAGGAGAAGCAGACGTTGGATGCTGCAGCCCTTAACAGACG
|
11235429ACGTTGGATGACTCTGCTTCTCCTACATGGACGTTGGATGGAAGTTCGCTATTCAGTGGG
|
1939242ACGTTGGATGCTCCTCTCTGCTTTCTCTTCACGTTGGATGCCTTGAAACACACAGGTAGC
|
9666346ACGTTGGATGAAGTGCTGGGATTACAGGTGACGTTGGATGTAATGAGGGCACACAAGAGG
|
7101553ACGTTGGATGAAGTGCTGGGATTACAGGTGACGTTGGATGTAATGAGGGCACACAAGAGG
|
7124000ACGTTGGATGTAATCCCAGCACTTTGAGAGACGTTGGATGAGAACTCCGCCTGGCTAATT
|
12291664ACGTTGGATGGCTGTGCCTAGGCAACATAGACGTTGGATGTACAGGTGTGTGCCACCATG
|
12291778ACGTTGGATGGTCACAATCATTGGCTACAGACGTTGGATGGGGACTCTGACACTAAAAAAG
|
12291781ACGTTGGATGGTCACAATCATTGGCTACAGACGTTGGATGGGGACTCTGACACTAAAAAAG
|
12291787ACGTTGGATGAAGGAATTCTCCCACCCTAGACGTTGGATGGTCACAATCATTGGCTACAG
|
12291788ACGTTGGATGAAGGAATTCTCCCACCCTAGACGTTGGATGGTCACAATCATTGGCTACAG
|
12291833ACGTTGGATGTTTAGTGTCAGAGTCCCAGCACGTTGGATGGGCATGATCTCTGCTCATTC
|
10793016ACGTTGGATGGGTACCTACTTCATTAAGGGACGTTGGATGAGCTAATGCTTACTGAGTGC
|
5792571ACGTTGGATGCCTACAATCTAACTCCTCCCACGTTGGATGCATCAGTCTGCCTCTCTAGA
|
12293529ACGTTGGATGTCCCTACAATCTAACTCCTCACGTTGGATGTTTACTTTAGGGTCCAGCTC
|
4338555ACGTTGGATGGGAGGAGTTAGATTGTAGGGACGTTGGATGAGGGCAAGACTCCATCTCAA
|
11235431ACGTTGGATGTCTGGCCACCAGAGAATGACACGTTGGATGTACAGCAATGAGCCTTGGTC
|
6592458ACGTTGGATGGGAGAATTGCTTGAATCCTGGACGTTGGATGTTGTTACCCAGGGTGTAGTG
|
4945434ACGTTGGATGGAAGAAATCTGAGGCTCAGGACGTTGGATGATAGGGACAAGGTAGACAAC
|
4945435ACGTTGGATGAAGAATCACATGAACCCGGGACGTTGGATGTTCAAGATGGAGTCTCGCTC
|
11307657ACGTTGGATGGCCGTGTGCTTTTCCTCATGACGTTGGATGTGAGGTCGTGCCATTGTACT
|
5792573ACGTTGGATGGCCGTGTGCTTTTCCTCATGACGTTGGATGTGAGGTCGTGCCATTGTACT
|
1894004ACGTTGGATGTGAGGATCCGAGAGCTTTACACGTTGGATGCATCCCTCCTAGTACAAGAC
|
12276164ACGTTGGATGTTACCATGGCCTCATTGTCCACGTTGGATGGAAGCCTCAGACTTACCAAC
|
4378421ACGTTGGATGTTTTTGAGACAGGGTCTTGCACGTTGGATGAGAAGTTTGAGGTTGCAGCG
|
7116495ACGTTGGATGCAAGTAGCTGCTGCTACAACACGTTGGATGTAGCGAGACTTCATCGCTAC
|
7101701ACGTTGGATGATGAAGTCTCGCTATGTTGCACGTTGGATGACACTTTGGGAGGTCAATGC
|
10736786ACGTTGGATGCGCTCCTTTAAACCAGTACCACGTTGGATGTGGGGAGCTAAAGAGAACAC
|
11608165ACGTTGGATGTTGGAGACTTGTTCCCTCTGACGTTGGATGTTGCACTGCATTCTGTAAAG
|
645603ACGTTGGATGTACATCTTCAGTACAGATGCACGTTGGATGCCACATGTGTGGATTCAACC
|
661290ACGTTGGATGGTCTCTGCCTTGCATAGATCACGTTGGATGAACAGGAATCCCCAGAGATC
|
7122209ACGTTGGATGAGCTGTGGAATCTCAAGCAGACGTTGGATGGAAAGACAGTGACACCAATG
|
12417471ACGTTGGATGCTGAAGTCTCAGCTACTCAGACGTTGGATGAATCGTAGCTCACTGAAGCC
|
541228ACGTTGGATGTAATCCCAGCACTTTGGGAGACGTTGGATGTTTTACTATGTTGGCCAGGC
|
12273666ACGTTGGATGATTACTGGCATGAGCCATCGACGTTGGATGGATTATCAGTTTGGCTTGCC
|
2511074ACGTTGGATGTCCAGCCTAAGAAACAGAGCACGTTGGATGACCGCACCCAGCTTAGTTTT
|
3018311ACGTTGGATGAAAACAAACTAAGCTGGGTGACGTTGGATGAGAGACAGGGTTTCACTATG
|
3018289ACGTTGGATGAGAGACAGGGTTTCACTATGACGTTGGATGAAAACAAACTAAGCTGGGTG
|
679926ACGTTGGATGACTTGCCAGGATTAGGAGTGACGTTGGATGAGCTGCTTCCAACTCAACTG
|
567026ACGTTGGATGATGTGAGCACAGCTAGCTACACGTTGGATGTTGTTTGGAGAGCTCCTGGG
|
564294ACGTTGGATGATATGTTCTGCAACTTGCCCACGTTGGATGTGCTGGTATGGAAACATGTC
|
678193ACGTTGGATGTGCTGGTATGGAAACATGTCACGTTGGATGATATGTTCTGCAACTTGCCC
|
677279ACGTTGGATGCTCCTGGTAGCTGGGACTAAACGTTGGATGGAACAGTTTGGGCAACATGG
|
560777ACGTTGGATGGTGGCACATTCTTACATAGGACGTTGGATGCAAAGTGCTGGGATTACAGG
|
676721ACGTTGGATGTCCAGATGTAGCAAAATGGGACGTTGGATGTGGCTGGCAATTCCTTAAAC
|
7106529ACGTTGGATGATTTGGGAATATCTGTTGACACGTTGGATGCAAGCTAATATTTCTCTAGG
|
11602304ACGTTGGATGATTGCAGGTATGAGCCACTGACGTTGGATGCAGAGTGAGACTCCATGTCG
|
585228ACGTTGGATGATTTGGGAGAGAATGCGAGGACGTTGGATGGTGGAGGAACTCAGTGTAAC
|
578957ACGTTGGATGTCTTTTTAATTTCTCCTCGCACGTTGGATGTTCGTGGAGAGTATGATAGC
|
7110215ACGTTGGATGGCTATCATACTCTCCACGAAACGTTGGATGGGTTTCACCATGTTGGCCAG
|
3133233ACGTTGGATGAGGTGAAAGGATTGCTTGAGACGTTGGATGCACCACCATGCCTAGCTAAT
|
3133230ACGTTGGATGTCAAGTGATCCTCTCACATCACGTTGGATGCAACATAGTGAGACCTCATC
|
12576024ACGTTGGATGCAGCTTATTATGGCTTCAGCACGTTGGATGTATAGTCCCAGCTACTCAGG
|
674319ACGTTGGATGAAATAGCTGGGCATGATGGCACGTTGGATGATCTTCCCGCTTTAGCTTCC
|
675185ACGTTGGATGAATGACATGGGGAAATACTCACGTTGGATGCACCCAGCCTATATCCTGC
|
5792574ACGTTGGATGTTCAAAAATGGGGCCATACCACGTTGGATGAGAGTGAGACCCTGTCTCAA
|
12275272ACGTTGGATGGTACTGTAAGAACCAGGACCACGTTGGATGGCCCGGTCTTGTCTATTCTT
|
10400327ACGTTGGATGCTGCCACTTTAAGAGGACTGACGTTGGATGTCTTCTTTCCCTCATTGCCC
|
612255ACGTTGGATGGTTTGACTACTGGACTTGGGACGTTGGATGTCTGATCACCCAGCTGTGAC
|
7101643ACGTTGGATGGATTCTGTGACTAAGTTACTGACGTTGGATGTAGCATCTCTTAACTCTTTC
|
575871ACGTTGGATGAGCCTGGTCAAAAGATTCTGACGTTGGATGTAGCATCTCTTAACTCTTTC
|
547208ACGTTGGATGGATAATGGAGAAAACTGGCCACGTTGGATGAGTCTGGGTGACAGAGAGAG
|
2511075ACGTTGGATGTTGAAGATTTCTTCCAGGGCACGTTGGATGGGGCAAGACATGTACAATATC
|
642573ACGTTGGATGAGATCCTGCTCAGGACAAAGACGTTGGATGTCCACCAGGAGGTAAGTCAA
|
482197ACGTTGGATGGAAAATGAGAGTGGTGTGGGACGTTGGATGCTGCCCTGTTAGGATTTCAG
|
656640ACGTTGGATGTGGGACCCAGGCACACTCCAACGTTGGATGCTTGAGCTCAGGAGTTCCAG
|
671681ACGTTGGATGGAAATACTTGCTGAAATAGGGACGTTGGATGACATTTTGCCAAATTTGCTG
|
541022ACGTTGGATGACTACCTAAGGAAACTGGGCACGTTGGATGCTACTATACCCCTCATGAGC
|
951586ACGTTGGATGAACCAAGGTAAAGGGTTGGCACGTTGGATGCTACAGCCATCAGATACCTC
|
2511076ACGTTGGATGCAAAGTGCTGGGATTACAGGACGTTGGATGTTTCTAGACAGCTCCTCCTC
|
1123543ACGTTGGATGAGTAGCTGGGACTACAGGCAACGTTGGATGAGGAGATAGAGACCACGGTG
|
3018308ACGTTGGATGAGTAGCTGGGACTACAGGCAACGTTGGATGAGGAGATAGAGACCACGGTG
|
11606798ACGTTGGATGATAATGGCCTCTCCTCTACCACGTTGGATGAGCGAGACCCTGTCTCAAAA
|
1791544ACGTTGGATGATTACAGGCCTGATCCACCACGTTGGATGTAGAACTTAGCTCACAGAGC
|
3018304ACGTTGGATGCCTCCTGGGTTCAAGCGATTACGTTGGATGAGACCAGACTGGCCAACATG
|
10751193ACGTTGGATGTCTCTCTATCACCCAGACTGACGTTGGATGTTGAACCTGGGAGGTGGAAG
|
4945470ACGTTGGATGAATCACTTGAGCCCGAGAGGACGTTGGATGATGGAGTCTCACTCTGTCG
|
3018291ACGTTGGATGAGATGGAGTCTCACTCTGTCACGTTGGATGACAGGAGAATCACTTGAGCC
|
2511120ACGTTGGATGGGTAGATTTGGAGCTGAGAGACGTTGGATGATATGCCTAGAAGTGCTCAG
|
671132ACGTTGGATGAACAGAAGTTGGTTCTTCCCACGTTGGATGGCCTTACTTAGCTGATGCTG
|
4945475ACGTTGGATGTTATTCTCCAGGCTGGAGTCACGTTGGATGAGGCAGGAGAATCGCTTGAA
|
3018292ACGTTGGATGAGCATGAGAAATCTTTTGGGACGTTGGATGCTACACCTGTAAACAGCAGC
|
642618ACGTTGGATGTCTCAGATCTCATGCGTAACACGTTGGATGCCAGAAGTTAACACAGAAAG
|
552966ACGTTGGATGCCCAATCATTACCTCTTTACCACGTTGGATGATGTAGACGACAGAATGAGG
|
6592459ACGTTGGATGGGAGAATGGTGTGAACCTGGACGTTGGATGAGATGGAGTCTCACTCTGTT
|
607446ACGTTGGATGGATCATTCCCAAAGTCAATCCACGTTGGATGCATGCCCAGCTACAAAATAAT
|
607070ACGTTGGATGCATACCAAAAGGTGTTGTCCACGTTGGATGAGAGATGGATTGACTTTGGG
|
10713307ACGTTGGATGTAAAATACCAGATGGCAGGCACGTTGGATGAACTCTTGACCTCGTGATCC
|
3018302ACGTTGGATGTTTGGGTTTATGGGTTGGGCACGTTGGATGACTGACCAGTCCAAGACAAC
|
3750909ACGTTGGATGGTTGTATCTTGTTCGCCGTGACGTTGGATGGCACTCACAGAACGACTAAG
|
3018301ACGTTGGATGACTAAGAACCTTCCTGCTCGACGTTGGATGTCTGTCCCATGTGAGTGTTG
|
2511114ACGTTGGATGAACACTCACATGGGACAGACACGTTGGATGGGGTGGTTCTTAAGCATCCC
|
12270166ACGTTGGATGTGAGGTAGAAGGATCGCTTGACGTTGGATGTGGAGTGTAGTTGCGTGATC
|
12270241ACGTTGGATGTTCTGAGGGCGTTTCTGATCACGTTGGATGCCCCAACGCAAACATAAAGC
|
11606587ACGTTGGATGCGCTACTCAAAGCTCTACAGACGTTGGATGGAAAGCACTGGGTAGGTTAC
|
686340ACGTTGGATGGTCTCATTGTCTTAGTCTCTCACGTTGGATGGCTGGAATGAATTTCAGATCC
|
548961ACGTTGGATGAAAAAAAAATTGGGGGTGGGACGTTGGATGTATTTGCGCACTGCAACCAG
|
549032ACGTTGGATGTACTGTTCACTCTCTACCCCACGTTGGATGCAAGAGCGAAACTCTGTCTC
|
575831ACGTTGGATGATTACAGCAACCTCATGGCCACGTTGGATGATAGTGCCGGCAAGTAGTAG
|
575878ACGTTGGATGATAGTGCCGGCAAGTAGTAGACGTTGGATGATTACAGCAACCTCATGGCC
|
577435ACGTTGGATGGATTGCCATGGTAGCACTCGACGTTGGATGCCCTGCTGGTGTTTATGGAC
|
579320ACGTTGGATGAAGATTCAACCTGGCTCCTGACGTTGGATGTGCATTTGGCTAGACTGCAG
|
495567ACGTTGGATGTTCTGTCAACTTGGGATTGGACGTTGGATGATTGTTGTAGACTATTACCC
|
636946ACGTTGGATGAGACCAGCCTAAGCAACATGACGTTGGATGTTAGCTTCCTGAGTAGCTGG
|
493065ACGTTGGATGTGATCAGCTGGAGGGTTATGACGTTGGATGATGGCTTCAGCTGGTATCTC
|
597513ACGTTGGATGCATTTCTTCTGGTCAGGCACACGTTGGATGAGTCCACACCTTGTTCACAG
|
598835ACGTTGGATGTTTTGTGTAGCACCAGCTCCACGTTGGATGTTTAACCAGCTTCTTGGGGC
|
10683614ACGTTGGATGTTAGGAACTGCACTGGGTTGACGTTGGATGTTGGTACCCCAGAGTTATGC
|
610004ACGTTGGATGAGAAGCTCATCCCACTTCAGACGTTGGATGGGTACCAACCCAGTATTTAC
|
610041ACGTTGGATGCTGTTGTAGGTGCTGAAGTGACGTTGGATGCTGGCTGTCTACTACAGAAC
|
673478ACGTTGGATGTAATACAAAGGTGGCAGCAGACGTTGGATGTTGACAAGGATAAGGACAAG
|
670802ACGTTGGATGGAGACTGTCTTGATACCCACACGTTGGATGCAGGCCCTCAAGGATTTGTT
|
505041ACGTTGGATGATAGCCCCCTGTTTCCTTTCACGTTGGATGGGAGAGTGAGAGGTTTTTTTC
|
2511116ACGTTGGATGGGGACAGAGTTGCCTAAAACACGTTGGATGCTGTGGCAGCCTGGATATAC
|
628025ACGTTGGATGTTCCTAATCCTGCTTCCCTCACGTTGGATGCTGCTACCTTATCACATGGG
|
517837ACGTTGGATGGAATTCCTAATCCTGCTTCCACGTTGGATGCTGTGTCATTCTGTTTCAGG
|
615000ACGTTGGATGTGCTTCAGTGGAATGGCAAGACGTTGGATGAAACCAGCCTCCATTCACTC
|
482013ACGTTGGATGGCCTTGGAGGAGCTTATATGACGTTGGATGCTCTTCTGTGCTGCTACAAC
|
693391ACGTTGGATGCACTTTGATATCCTGTCTCTCACGTTGGATGATCACTGTATATCCAGTACC
|
2511079ACGTTGGATGAGCTGAGTAGATGATAGCACACGTTGGATGGGAAAGAGAGACAGGATATC
|
2250866ACGTTGGATGCCCCCTAAAGCCAAAAAAGCACGTTGGATGTCCTTGGCTCCTCATTTACC
|
2508860ACGTTGGATGAAGTGCTGGGATTACAGGCGACGTTGGATGCTCCCTGTCGGAAAAATGGG
|
7483267ACGTTGGATGGAAACCCCGCCTCTACTAAAACGTTGGATGAAGTGATTCTCCTGCCTCAG
|
2511078ACGTTGGATGGAAACCCCGCCTCTACTAAAACGTTGGATGAAGTGATTCTCCTGCCTCAG
|
2508859ACGTTGGATGAGCCTCTGATGTACCAGTTGACGTTGGATGTGGCAACAGAGTGAGACTCC
|
2508858ACGTTGGATGTACCTCTTCCACAGGAGAACACGTTGGATGACAACTGGTACATCAGAGGC
|
11235435ACGTTGGATGAGCATGATGCTCTGTCTTCCACGTTGGATGCCCTTCACTGAAGACCTTTC
|
11235436ACGTTGGATGGTCATACAGTATGGCTGTGGACGTTGGATGTGGGCAGAGAAGGAAGAATG
|
639435ACGTTGGATGGACCCTAGTAGTCCTAAAGGACGTTGGATGCTTCTCATCTGCTCAACAGC
|
12285624ACGTTGGATGTTTTTGAGACGGAGTCTCGCACGTTGGATGTGAACCTGGAAGGCGGAGTTT
|
NUMA1-ADACGTTGGATGCCTGGCTAACATGGTGAAACACGTTGGATGGGACTATAGGCACCTACTAC
|
624363ACGTTGGATGTTATCTAACTCTCTGGGCCCACGTTGGATGCCTGGTACTCTGTGAAGAGT
|
NUMA1-AEACGTTGGATGAGGCAGCTTTGATTCTTGGGACGTTGGATGTGGTCTGCTTTCTCTCTCCA
|
1053573ACGTTGGATGTATCGAGGGTGACAAACCAAACGTTGGATGGTCTGGATGAGCTTGAATTTG
|
1053511ACGTTGGATGGACCTAGGGAGATCCCCTTCACGTTGGATGTGAGCACCAAGTCAGGGAGA
|
1063863ACGTTGGATGTGAGGCCAACAGAGAGGGTGACGTTGGATGTGGAGATACCAGTTTGGGTG
|
12137ACGTTGGATGTGAAGACATACCAGGCTCTGACGTTGGATGGGTAGAACC1TTTGGGACTG
|
4365081ACGTTGGATGTTCTACCCTCACTTGCTCAGACGTTGGATGACAGTACCCTAACCTGCTAC
|
4466868ACGTTGGATGACTGCGGCTTATACAGTACCACGTTGGATGTTCTAGCCTTCCTCTTCTCC
|
3750911ACGTTGGATGGGATCCCAAACTGTACAACCACGTTGGATGGGATAGCTGCTTATGCCTAC
|
510925ACGTTGGATGGATGAGGCTTACCTGGGCTGACGTTGGATGGGGTGCTGACCAAGAGAGAG
|
595062ACGTTGGATGTCATGTCAGCCCTGTTTACCACGTTGGATGAGACTCAATCTAGGCCCATC
|
1053443ACGTTGGATGTCTCTTCCATCCTTGCCAAGACGTTGGATGTGTACTCATGCTGCTCCATG
|
542752ACGTTGGATGCCTTTAGATCCCAGTGCTTGACGTTGGATGCTAGGACCTGGCAAAGAAAG
|
3897579ACGTTGGATGCAAGAACAGCCTTCCTCATCACGTTGGATGTAGGGCTTTGTCTGGACTCG
|
11235437ACGTTGGATGAACAGCGCCATTGTTGTTTGACGTTGGATGTATGAACCCAGGGTTTGAGG
|
2508856ACGTTGGATGTTGGTGAGTCAGCATTAGCCACGTTGGATGCATAAAGAGCAAGAGTGCCC
|
5792575ACGTTGGATGATGGAGCCAGCTTTCCTTAGACGTTGGATGCACCCTTCCTCCCTAAATAC
|
659513ACGTTGGATGCCATGTACTTTATCCATGGGACGTTGGATGCTTAGCACAGACATAGCAGC
|
10898820ACGTTGGATGAACCCACACTAATATGACGGACGTTGGATGCGTTACAGTTTACAAAGGGC
|
2276397ACGTTGGATGTGGGTGAGTGAGCAGCTAGACGTTGGATGGATTTCTGGAGTAAGGCTGG
|
3750908ACGTTGGATGGCTTTCCTGCTGTCTTCCACACGTTGGATGAAGGGTCAAGTGAATGTGTT
|
3793938ACGTTGGATGAAAAGCAGGACCAGGCATCGACGTTGGATGTAGGTCATACAGTGTGTCGG
|
602285ACGTTGGATGAACCCTTAAAGAGCTCCAGCACGTTGGATGGTGACACCAATGAATGACGG
|
2276396ACGTTGGATGTTAGGGAAGGAAGTGTGCCGACGTTGGATGTAAACGAGACCGTAGTGCTG
|
2276395ACGTTGGATGACAGTCCAGGGAAGCCAAACACGTTGGATGGTCAAAACTCAACAAGCAACC
|
1806778ACGTTGGATGAGCTTGCAGTGATCCGAGATACGTTGGATGGTGTTGTTCATGGTCAATGG
|
4073394ACGTTGGATGTCCTTCTTCTTTACTGGGTCACGTTGGATGTCCTTGCACCAGAGCTAATC
|
471547ACGTTGGATGCAGGGCCTTACCTCCATTCTACGTTGGATGTCCTAGACAAAGCCTTGTGC
|
606136ACGTTGGATGAGGAGTGAGACTCTAGACAGACGTTGGATGAGCTTCCCTGGGCATCTAAA
|
605241ACGTTGGATGACTGGAGAAATCCAAGAGGGACGTTGGATGCTCCACCAACAGCGCTGTAG
|
686063ACGTTGGATGCATCACTTGACCCTAGGTGCACGTTGGATGTCTTGGGAAGTCACTCTAGG
|
685749ACGTTGGATGCATCACTTGACCCTAGGTGCACGTTGGATGTCTTGGGAAGTCACTCTAGG
|
533207ACGTTGGATGACAAGGCAGGTAAGACAAGCACGTTGGATGCTCAGGTTTTCTGAGTCCTG
|
476753ACGTTGGATGTCCCTGGGCATCTAAACCTCACGTTGGATGAGGAGTGAGACTCTAGACAG
|
NUMA1-AFACGTTGGATGCAGGATGCAGAAAACCTGAGACGTTGGATGCATCACTTGACCCTAGGTGC
|
TABLE 29
|
|
|
dbSNP rs#
Extend Primer
Term Mix
|
|
|
4945392
AAATCTCTTTTTCTGTTGAGT
ACT
|
|
7938496
CTGCACTCCAGCCTGGG
ACG
|
|
7926550
GAACTCCTGAGCTCAAA
ACT
|
|
7945374
AGCTCTATTCTCCAGGG
CGT
|
|
7949480
TCCTGACCACATGATCC
ACT
|
|
7102523
CCACACCCATCTGTGTC
ACT
|
|
7121260
AATTAAGTGGTGTAAGATCAAT
ACT
|
|
7131230
CACCGGAGTAATTTTCAG
ACG
|
|
7128317
TTAGTCCTTGCCTCCCC
ACG
|
|
2276385
GGCAAACTATGACCAAATC
ACT
|
|
2276384
TTGGTCATAGTTTGCCC
ACT
|
|
2276383
AGAAGGCCCAAAGGCTA
ACT
|
|
1892921
CCTAACAGATAGTTTTTCAAC
ACG
|
|
1892920
CACTTTTGTAATTCTGGCA
ACG
|
|
7942626
TGCGTTTCTCAGATTGG
ACG
|
|
7124429
TCAAATTGAAAACAGTACATTG
ACT
|
|
711408
TTTTGGAATTAGACAGTGAAA
CGT
|
|
7125718
GTAACTCATTACCCCTTC
ACG
|
|
1055452
TCCTGAGTGGCCCAAGC
ACT
|
|
3829215
GCCACTCAGGACCCCTC
ACG
|
|
1541306
AGTTGTCCCAAAACAAAT
ACG
|
|
3814722
CCATATTCCCTAGAAACC
CGT
|
|
1939240
CTCCTAGGGATGTCAGC
CGT
|
|
5743655
GGAAGGCAGGTGGTGGC
ACT
|
|
5743656
GCTTCTCTTCCCCAGCT
ACT
|
|
5743657
GTCCAAAGCTCTTTTCAT
ACT
|
|
3814721
ACCCCAGGCAGCCTTGC
ACG
|
|
5743658
CATCCTAGGTTCCTCAC
CGT
|
|
5743659
CCCTTCCCTCCTGTTAG
ACT
|
|
5743660
CAGGCTACCCACTCCCC
ACG
|
|
5743661
TCCCAGGCTACCCACTC
CGT
|
|
5743662
GGACCACTTCAGGCTCA
ACT
|
|
2298455
GATACCAGACTGGGATC
ACT
|
|
5743664
TAGACCTCACCCTACCC
ACG
|
|
5743665
CCTTCACTCCAAGGCAA
ACT
|
|
5743667
GAGATGTCTGGGTTCTAG
ACG
|
|
5743668
CAGCGGCTCTGGAGACA
ACT
|
|
5743669
CCTTGGTTGCAGTGGAC
ACG
|
|
1573503
TGGGAGCCCAGGTGACA
ACT
|
|
5743670
ACGTCCGTTACAGAAGT
ACT
|
|
5743671
CCTAGAGAACTGCTCTG
ACG
|
|
1892919
TGCTCTGCTGTGCCCTC
ACG
|
|
5743672
TGCTGAAGTTGGGGAAG
ACG
|
|
2735786
CAGGTGGGTGGGAAGGA
ACT
|
|
5743673
CTGTGCTCCCACGTTCC
ACG
|
|
5743674
ATTAGTTCACAGGCTGC
CGT
|
|
1062452
TGTAGGCTGCGTGGATG
CGT
|
|
5743675
AGAGAGAATGGCAGGAG
ACT
|
|
5743676
CCATTAGCCTTCCTAAC
ACT
|
|
760246
GAACGCTCAAGCCTGGT
ACG
|
|
11345794
CAGGGGAACACAGGCGCT
ACT
|
|
5743677
AAAGAAAAGAGAGAACAGC
ACG
|
|
5743678
TTCCCACACCGATCAAG
ACT
|
|
14537
CCGGGGATGGATCTTTT
ACG
|
|
3168177
CCCACCCCAGTGCAAGT
ACG
|
|
5743679
CCTTCAGCAGCAGCTCA
ACG
|
|
1541304
ACCCCACTCCTGAGACA
ACG
|
|
1053725
GATCTAGAAGGGACCATAA
ACT
|
|
5743680
CAAACCCCTAGAGACAG
ACG
|
|
949324
GGCGGAGGACCAGGTGA
ACT
|
|
949323
CGGAGGACCAGGTGAGG
ACT
|
|
5743681
TGGGGCTCACAAGGGAG
ACT
|
|
5743682
ATAACCCTGGGGCTCAC
ACT
|
|
5743683
ATTCTCATGGAGAGCAC
ACG
|
|
5743684
GCCACCACCACAGCCAG
ACG
|
|
5743685
GTTGAGGATGCTGAAGG
ACG
|
|
2845857
GCGGGACCTTGCTGATA
ACT
|
|
2852365
TGCTGTGCCACGCTCTA
ACG
|
|
11538641
CCCACGCCCCATGACTCC
CGT
|
|
11538639
GGCCACCAGCTGTTTCCCA
ACG
|
|
11235417
GGACAGTTAGGCAGACAGTA
ACT
|
|
11538644
AAACGGGTCTCCCTAGAGC
CGT
|
|
11538643
GACCCCCAAGAGACCCTG
ACG
|
|
2845858
CGAGTGTAGAGTTCTGG
ACT
|
|
2155146
GAGCTCCTGCCTACCCC
CGT
|
|
2852364
CAGGTGGGATTCCAAGG
ACT
|
|
2845859
CCATAAACTTGAAGCCC
ACT
|
|
2845860
CAAGCCTTGGCAGGTGA
ACT
|
|
11538642
CTGGGAAGCAGGAGCAGAC
CGT
|
|
7949430
GTCTTCCAGAAGCTAGAT
ACT
|
|
7938674
AGTGCCAGGGACTGTAC
ACT
|
|
2735787
ACAAAGGCAAGGGCCTG
ACG
|
|
11538640
CACCTATCTCCCAGCGCC
ACG
|
|
10736784
CACCAAGCTTCCTGAACAGC
CGT
|
|
10736785
TGGAGTGGGGTGTGGTTAG
ACT
|
|
11826059
AAGAATTTGAAACTGAAGAGTAC
ACT
|
|
2503
AGGCCCATTGGAGACCG
ACT
|
|
2155145
TGGTATAATACCCGTTTTTC
ACT
|
|
4477459
GATGTGGACTGAAGGGC
ACT
|
|
NUMA1-AA
CCAAGTGCCTTAGAGTA
ACT
|
|
5019605
ACCCAGGTGCAGAGCCTTA
ACT
|
|
5019604
CATGCCAAGTGCCTTAG
CGT
|
|
5019603
AGGTGCAGAGCCTTACT
ACT
|
|
3793941
AACACTGGTGACACTCT
ACG
|
|
11235418
GGCTTCCTAGGAGGGCTAC
ACT
|
|
3793940
GCTCTTCCTCTTTGTAG
ACT
|
|
2032353
TGGGCAAGTGTCCTAAG
CGT
|
|
3934448
TAAGCCCACAATCCTCC
CGT
|
|
7951267
ACCCCTTGTCCCTGATA
ACT
|
|
1053603
CCAACTCTTGGACATACTT
ACG
|
|
1053602
ACAGGCCCCAAGCTGGA
ACT
|
|
11235419
CGGGAGGCAGAGCAGATG
ACT
|
|
1053601
TAAGCCGGCAGCAGAAC
ACT
|
|
3750913
CTCAGCTGTGTGCTGGGCA
ACT
|
|
3750912
CTTGGGGAGGCCCATCA
ACT
|
|
1053600
GCTGGAGGCTCGATTAC
CGT
|
|
1057992
GTGAGTCCACACCAACC
CGT
|
|
2298789
GAGGAAGGGTATACGGT
ACT
|
|
10898813
CTATGCTGGGTTCATCCCTAA
CGT
|
|
11278712
GAATCCCCATCACCCAGAG
ACG
|
|
NUMA1-AB
CAGTGAGAAGAGAGTATGGG
ACG
|
|
949325
TCCTCTTCCCTATGCCG
ACG
|
|
NUMA1-AC
GCCTGTTGCTGATTGCTTCA
ACT
|
|
949326
GAATACCCTTCTTCCTC
ACT
|
|
2298456
GCATAAAGGTGCAAATCTTT
CGT
|
|
7949845
GATGTCAGGAGTTCGAGACC
ACT
|
|
7949989
CCAGCTACTCGGGAGGCT
ACT
|
|
1573500
CCCAAGTAGCTAGAACTA
ACT
|
|
4945411
GAAGTGAAAGTTCTGTGGGG
ACT
|
|
3831387
GGGAAAAAAAAACACACACACA
ACT
|
|
11235422
GCCAAACAGGAGGCAGTCA
CGT
|
|
10128658
GGCTGTCTCTCTTCTCAGTG
ACG
|
|
2298457
AGTTCACCCTGTTTTCT
ACT
|
|
3838779
CCGAACTTCAAGGAGACAGAA
ACT
|
|
1573501
TCATCTGTGCTGCCTCC
ACT
|
|
11235424
CGGAGGCAGCACAGATGAA
ACG
|
|
10898814
GTTGAAGGCTGAGATGGCAAA
ACT
|
|
7930142
CTGAGAACCTCTTTTTATTTTA
ACT
|
|
7930544
CCATTTACAACTGCCCA
ACG
|
|
7930721
TTTGCCAGAAAACTTAGAG
ACT
|
|
7930722
GACAAAAATGTCAGACCT
ACT
|
|
6592456
GGCCAAGTGGCCAAGCA
ACT
|
|
11235425
GTAGGCGATATTGAAATCCCA
ACT
|
|
6592457
CACTGTAGGTTTATAACCTG
ACT
|
|
10898815
TACCAGTTCCTAACTGCCAC
ACT
|
|
11235426
TTGCCCCAGGCCAAGGATA
ACT
|
|
10898816
CTTGGCCTGGGGCAAACAAT
ACG
|
|
1939247
GGGCTCTCTGATGGTTGCAT
CGT
|
|
1939246
GGACACTATCATAGCTCAT
ACT
|
|
1939245
AAGTTGTTTTTAAATGTGAAAGT
ACT
|
|
1939244
GGCCCATGCCTGTAATC
CGT
|
|
1939243
GAGTAGCAGGGACTACG
ACG
|
|
4245463
CAAGACCCTATCTCAAAAAG
CGT
|
|
4944258
GGCCTGAAGTTTTCAGA
CGT
|
|
7926751
TCATGCATGTTCTTTGTTT
ACT
|
|
12282917
ACGTGGTGAGACCCTGTCT
ACG
|
|
12282918
CAACGTGGTGAGACCCTGT
ACG
|
|
7937582
CCTGGGCAACGTGGTGA
ACT
|
|
10898817
AGATGGAGTCTTGCTCTGTC
ACT
|
|
7480015
GAGGCTGAGGCAGGAGGAT
ACG
|
|
7123992
CATTAAGGTCAGCATTTACCAC
ACG
|
|
1573502
AGACAAGCAACATAACCTCTTT
ACG
|
|
7127865
AGAACACCAGGACAGGTGC
ACT
|
|
4945426
GAAGGTGCTCACTGTCTAGTA
CGT
|
|
11235428
GTCTGGCTGTTGCCGCCC
ACT
|
|
7122489
GCTACAATCGCAAGGATCTG
ACT
|
|
1894003
AAACCACCTGCTCAGAC
ACT
|
|
1548348
CTCCTGGCCTATCCGTCC
ACG
|
|
1892923
TGGGGCGCGTACACATACA
ACG
|
|
5792570
AACCCTTTGCTCTGAAAGGC
ACT
|
|
7115200
TGCCTGGCAGGAGCGATC
ACT
|
|
4945430
AAGCAGAGTCTACAAGTCCC
ACT
|
|
11235429
GTCTGACTCTTAGAAGACAAAA
ACG
|
|
1939242
CCACACCTCTCTGTTTC
ACG
|
|
9666346
GTGAGCCGTCGTGCCAAG
ACT
|
|
7101553
GGGATTACAGGTGTGAGCC
ACT
|
|
7124000
GCAACATGGCGAAACCCTG
ACG
|
|
12291664
CAACATAGTGAGAGCCTGTCT
ACG
|
|
12291778
ATAGGCTAAAATGTTTTACATATAA
ACT
|
|
12291781
TAACCAGTAAAACTTCATGATTTA
ACT
|
|
12291787
CTCCTGAGTAGCTGGGACT
ACG
|
|
12291788
GCCTCCTGAGTAGCTGGGA
ACG
|
|
12291833
CAGGAGGCTAGGGTGGGA
ACT
|
|
10793016
TAGGTCAGTAGAATAGTGTCG
ACG
|
|
5792571
CTAACTCCTCCCCCCCCC
CGT
|
|
12293529
AATCTAACTCCTCCCCCCC
ACT
|
|
4338555
GGAACATTCACTTGGGGACTT
ACG
|
|
11235431
TGGTGGGTGGTTGGGATGA
ACT
|
|
6592458
GTTGTGGTGAGCCGAGATC
ACT
|
|
4945434
AGGCTCAGGAATTAGGTGAC
ACG
|
|
4945435
CCGGGAGGCAGAGGTTGC
ACT
|
|
11307657
TCCTCATGAAAATCAACTTTTTTT
CGT
|
|
5792573
TCCTCATGAAAATCAACTTTTTTT
CGT
|
|
1894004
GATCCGAGAGCTTTACAAACACT
ACT
|
|
12276164
CCTCATTGTCCCTCTCCAGA
ACT
|
|
4378421
GGCTGGAGTGCAGTGGCA
ACG
|
|
7116495
TGCTGCTACAACAGGCACG
ACG
|
|
7101701
TGTTGCCTAGGCTGGTCTC
ACT
|
|
10736786
CAGTACCTACTCTTATTTTCTC
ACT
|
|
11608165
CCCTCTGCTTCCCCCTGG
ACT
|
|
645603
CAGATGCTTTTTTTTCCC
ACG
|
|
661290
CATAGATCTAGTGGGCATC
ACT
|
|
7122209
GAAAATGATGATCCCCAAATCT
ACT
|
|
12417471
CTCAGCTACTCAGGAGGCT
ACT
|
|
541228
GGCAGGCGGATCACAAGGT
ACT
|
|
12273666
CATGAGCCATCGCGCCTG
ACT
|
|
2511074
AAGAAACAGAGCGAGACACC
ACT
|
|
3018311
CAGGTGGATCGCCTGAGG
ACT
|
|
3018289
TGTTGGCCAGGCTGTTCTC
ACT
|
|
679926
CCAGGATTAGGAGTGTGACAA
ACT
|
|
567026
CCTTGTCACACTCCTAA
ACG
|
|
564294
TCTGCAACTTGCCCTTTTCA
ACG
|
|
678193
ATGGAAACATGTCAAATAAATTT
ACT
|
|
677279
GTAGCTGGGACTAAAGGTGC
ACT
|
|
560777
TAAGGAATTGCCAGCCATGA
ACG
|
|
676721
CACATTCTTACATAGGATTTTTT
ACG
|
|
7106529
AATACACAAGCTTTTCAACCCA
CGT
|
|
11602304
GAGCCACTGTGCCCAGAC
ACG
|
|
585228
GACCCTATTACTTAAAATGAC
ACT
|
|
578957
TCTCCTCGCATTCTCTCCC
CGT
|
|
7110215
ACCTGAGGTCAGGAGTTTGA
ACT
|
|
3133233
CAGCCTGGGCAACATAGTGA
ACT
|
|
3133230
GGTGTGCACCACCATGCCT
ACT
|
|
12576024
TGGCTTCAGCCTCCCAGG
CGT
|
|
674319
TGGCATGCGCCTGTAGT
ACG
|
|
675185
ATGGGGAAATACTCAAGAAA
ACT
|
|
5792574
ATAATAGTTTTATCCTGCCTTTTT
ACT
|
|
12275272
CACCTTCTCTCAACCTAACCT
ACG
|
|
10400327
ACTTTAAGAGGACTGGCAAGA
ACG
|
|
612255
GGAGTGGAATTTCTTTTTTAC
ACG
|
|
7101643
GCAATTCTCTTTCTTACTCTAAA
ACG
|
|
575871
GCAATTCTCTTTCTTACTCTA
ACT
|
|
547208
GCCTTTCTTTTCTTTTTTTTT
ACG
|
|
2511075
CCAGGGCCAAAATTTATCATTAT
ACT
|
|
642573
CTCAGGACAAAGCTGACCTAT
ACT
|
|
482197
GGGCCTCCTGAGGAAGAAG
ACG
|
|
656640
GGCACACTCCACCACACCT
ACT
|
|
671681
AAAGATTCAGAAAATGAAGGA
ACG
|
|
541022
AACTGGGCATTTGGAGGTCA
ACT
|
|
951586
GGGGCCATTTGGCAGAA
ACT
|
|
2511076
ATTACAGGCGTGAGCCACCG
ACG
|
|
11235432
CCCGCCACCGCGCCCAG
ACT
|
|
3018308
CACCCGCCACCGCGCCC
ACT
|
|
11606798
CTACCTCCTACTGTGGGCAA
ACT
|
|
1791544
CTGATCCACCGCAGCCAG
ACG
|
|
3018304
TTACAGGCATGCGCCACCA
CGT
|
|
10751193
CCAGACTGGAGTACAGTGG
ACT
|
|
4945470
GTTGCAGTGAGCCAAGACTG
ACG
|
|
3018291
CTGTCGCCCAGGCTGGAG
ACT
|
|
2511120
TTAATAGCTGGCACAGTCTA
ACT
|
|
671132
GTTGGTTCTTCCCAGTTGC
ACG
|
|
4945475
TCCAGTGGTGCAATCTCGG
ACT
|
|
3018292
GAGAGAAATCCTCTGTATCT
ACT
|
|
642618
ATGTTGAACTTCCTCATTCTGT
ACG
|
|
552966
TCTCAGATCTCATGCGTAAC
ACT
|
|
6592459
GTGTGAACCTGGGAGGCG
ACT
|
|
607446
TCCCAAAGTCAATCCATCTCTAAG
ACG
|
|
607070
GTCCAGACTCAAAATGA
ACT
|
|
10713307
TGGCTCACGCCTGTAATCC
CGT
|
|
3018302
TGGGGACGGGGAAGGTGCT
ACT
|
|
3750909
TGGGGGAAATCTCAGATCCC
ACT
|
|
3018301
CCCTCATCACCTTTCAC
ACT
|
|
2511114
GGGATAGGCGTTGAGATATA
ACG
|
|
12270166
CCCGGAGATTGAAGCTGCA
ACT
|
|
12270241
TCTGATCTCCCAGGTTATGC
ACG
|
|
11606587
TCATTTTTTTTAGTACTCACGAC
ACT
|
|
686340
CTAGTTCCTTTTCCCCATTAAAA
ACT
|
|
548961
GTGGGGTAGAGAGTGAA
ACG
|
|
549032
CTCTCTACCCCACCCCC
CGT
|
|
575831
GCCCTCTCCTTTGTAGT
ACT
|
|
575878
GGTGCTTAACAAACACATTAA
CGT
|
|
577435
ATGGTAGCACTCGTAACACT
ACT
|
|
579320
GGCTCCTGTCCACCCCC
CGT
|
|
495567
AGTGAATAACATTAAAGTACGATA
ACG
|
|
636946
GCCTAAGCAACATGGCAAAAC
ACG
|
|
493065
GATGTGTAGGTGAGAGACATGC
ACT
|
|
597513
AGGCACAGAGCAGCAAGCAC
CGT
|
|
598835
CTCCTGTTGCATTTTCTGAATG
ACT
|
|
10683614
CTGCACTGGGTTGCTCTGT
ACG
|
|
610004
ATCCCACTTCAGCACCTACA
ACT
|
|
61004
TTGCTGAAGTGGGATGAGCTTCT
ACT
|
|
673478
AAGGGGAGGTCGACTGGG
ACT
|
|
670802
GTCTTGATACCCACCCTCTG
ACT
|
|
505041
ATCGGGGCAAAATCAAA
CGT
|
|
2511116
GGCTGGAGCTGCTCTTA
ACG
|
|
628025
TCCCTCCCCATACCTCCT
ACT
|
|
517837
AATCCTGCTTCCCTCCCCA
ACG
|
|
615000
GGAGGCAGAAGCCAGAT
ACT
|
|
482013
AAGATGGGAGCAAGCTGGCAA
ACG
|
|
693391
GATATCCTGTCTCTCTTTCCAT
ACT
|
|
2511079
GCCTATAGAATTCACTTCA
ACT
|
|
2250866
TAAAGCCAAAAAAGCAAAGAT
ACT
|
|
2508860
CGTGAGCCGCTGTGCCC
ACT
|
|
7483267
AAAATTAGCTGGGCGTGGTG
ACT
|
|
2511078
AATTAGCTGGGCGTGGTGG
ACG
|
|
2508859
GTACCAGTTGTTTGTTGG
ACT
|
|
2508858
GTGCGCAGTGACAGTTA
ACT
|
|
11235435
GCTTGCTGTGATAGAATCGTA
ACT
|
|
11235436
GTATGGCTGTGGAGGGTTG
ACT
|
|
639435
CCTAAGCATAGACAGCATGG
ACT
|
|
12285624
GACGGAGTCTCGCTCTGTC
ACT
|
|
NUMA1-AD
TGAAACCCCGTCTCTACTAAA
CGT
|
|
624363
GGGCCCCTTTGTACTTTTCA
ACT
|
|
NUMA1-AE
GGCCCTGCCTCAGACTCA
ACT
|
|
1053573
ACCAAACATGTAAAAACCC
CGT
|
|
1053511
GATCCCCTTCCCACCCT
ACG
|
|
1063863
GGATCTCCCTAGGTCCC
ACG
|
|
12137
TCCTTTTGGCCCCCACCC
ACG
|
|
4365081
CTCACTTGCTCAGGCTTCTA
ACT
|
|
4466868
ATACAGTACCCTAACCTGCTA
ACT
|
|
3750911
ACCAGCTCCTCTTTTGC
ACT
|
|
510925
CTGGGCAGGGCAGACTGT
ACT
|
|
595062
CTGTGACACTCTTGAGGGC
ACT
|
|
1053443
ATGTGTCTGCTGCAGACT
ACG
|
|
542752
TGCTATGTCTCAGCTCC
CGT
|
|
3897579
TGTTCGCTTCCAAGATG
ACT
|
|
11235437
AGTACAGTGGCACAGTCCTA
ACT
|
|
2508856
GGATGTCCCCCTGGGCC
ACG
|
|
5792575
TAGTTTTATCTTTGGCAAACATTT
ACT
|
|
659513
CCCTAGACCAGGTGGCCAGTCA
ACG
|
|
10898820
CACACTAATATGACGGATGTCT
ACT
|
|
2276397
GCTAGCACAGCACAGAGACC
ACG
|
|
3750908
GCTGTCTTCCACCCTATCCC
ACG
|
|
3793938
ATCGATTATTTTCTCCTGCT
ACG
|
|
602285
CTCGAGACTAAGCCCCACCC
ACT
|
|
2276396
GCCTACCTATCTGCCCC
ACT
|
|
2276395
AGACATGCAGTAGACTTAGT
ACT
|
|
1806778
CGACAGAGCCAGACTCC
ACT
|
|
4073394
TTACTGGGTCAGCTCCCTCC
ACT
|
|
471547
TGGTTAGACCCTCTGTT
CGT
|
|
606136
TGTCCTCCTACCCCATGGCA
ACT
|
|
605241
AGCAAGCTGGTGTCAGA
ACT
|
|
686063
AGCCCAGAAATTTTATGCAATTGA
ACG
|
|
685749
CATGATTTCTCAGGTTTTCTGA
ACT
|
|
533207
AAGACAAGCAGAAATGGTGGAG
ACT
|
|
476753
TCTAAACCTCAGTTGCC
ACT
|
|
NUMA1-AF
GAAATCATGAGTCAATTGCATAA
CGT
|
|
Genetic Analysis of Allelotyping Results
Allelotyping results are shown for cases and controls in Table 30. The allele frequency for the A2 allele is noted in the fifth and sixth columns for breast cancer pools and control pools, respectively, where “AF” is allele frequency. SNPs with blank allele frequencies were untyped.
TABLE 30
|
|
Breast
Cancer
Position inChromosomeA1/A2Associated
dbSNP rs#SEQ ID NO: 4PositionAlleleCase AFControl AFp-ValueORAllele
|
|
494539220371420953T/CT = 0.999T = 0.9980.9360.74T
C = 0.001C = 0.002
7938496123671421986G/AG = 0.988G = 0.9660.2330.34G
A = 0.012A = 0.034
7926550176871422518C/GC = 1C = 10.9560.00C
G = 0G = 0.000
7945374210171422851A/TA = 1A = 0.9990.9640.72A
T = 0.000T = 0.001
7949480314671423896T/CT = 0.126T = 00.00001660.00T
C = 0.874C = 1
7102523447671425226T/CT = 0.046T = 0.0310.3370.67T
C = 0.954C = 0.969
7121260612471426874A/GA = 0.954A = 0.9940.003066.99G
G = 0.046G = 0.006
7131230671971427469C/TC = 0.319C = 0.3680.1061.24T
T = 0.681T = 0.632
7128317692571427675G/AG = 0.906G = 0.9580.002392.33A
A = 0.094A = 0.042
2276385706071427810C/GC = 0.962C = 0.9960.003159.57G
G = 0.038G = 0.004
2276384708171427831T/CT = 0.996T = 0.9940.8640.74T
C = 0.004C = 0.006
2276383709071427840A/GA = 0.0660A = 0.0150.001940.21A
G = 0.934G = 0.985
1892921769671428446C/TC = 0.091C = 0.0360.00150.37C
T = 0.909T = 0.964
1892920798971428739C/TC = 0.997C = 0.9970.9731.09T
T = 0.003T = 0.003
7942626940771430157G/AG = 0.061G = 0.0260.09290.41G
A = 0.939A = 0.974
7124429969971430449T/GT = 0.001T = 0.0010.9560.25T
G = 0.999G = 0.999
7114081990571430655A/TA = 0.001A = 0.0010.9520.53A
T = 0.999T = 0.999
7125718998471430734C/TC = 1C = 10.9440.39C
T = 0.000T = 0.000
10554521302371433773T/CT = 0.106T = 0.0810.2110.75T
C = 0.894C = 0.919
38292151304771433797G/AG = 0.968G = 0.9840.221.95A
A = 0.032A = 0.016
15413061357171434321C/TC = 0.2C = 0.1310.003980.60C
T = 0.800T = 0.869
38147221408671434836C/AC = 0.999C = 0.9980.9530.79C
A = 0.001A = 0.002
19392401433771435087T/AT = 0.001T = 0.0020.88622.72A
A = 0.999A = 0.998
57436551446271435212T/CT = 0.007T =
C = 0.993C =
57436561451871435268A/GA = 0.003A = 0.0010.8190.29A
G = 0.997G = 0.999
57436571469571435445A/GA = 0.002A = 0.0020.9430.70A
G = 0.998G = 0.998
38147211483071435580G/AG = 0.152G = 0.0870.002110.53G
A = 0.848A = 0.913
57436581528271436032C/AC = 0.038C = 0.0210.3860.54C
A = 0.962A = 0.979
57436591543671436186A/GA = 0.004A = 0.0030.8920.67A
G = 0.996G = 0.997
57436601574571436495G/AG = 1G = 10.9670.62G
A = 0.000A = 0.000
57436611574871436498G/TG = 1G = 10.9810.40G
T = 0.000T = 0.000
57436621579771436547T/CT = 1T = 10.9980.96T
C = 0.000C = 0.000
22984551603671436786T/GT = 0.908T = 0.9190.571.15G
G = 0.092G = 0.081
57436641664671437396G/AG = 1G = 0.9990.9470.56G
A = 0.000A = 0.001
57436651671371437463A/GA = 1A = 10.9712.04G
G = 0.000G = 0.000
57436671685971437609G/AG = 0.999G = 0.9980.9240.64G
A = 0.001A = 0.002
57436681691471437664G/—G = 0.002G = 0.0020.9490.69G
— = 0.998— = 0.998
57436691742271438172C/TC = 1C = 0.9990.910.40C
T = 0.000T = 0.001
15735031749971438249A/GA = 0.044A = 0.0190.08080.42A
G = 0.956G = 0.981
57436701764671438396G/CG = 0.005G = 0.0040.9350.84G
C = 0.995C = 0.996
57436711768171438431G/AG = 0.999G = 0.9990.9391.51A
A = 0.001A = 0.001
18929191773371438483C/TC = 0.085C = 0.0460.02690.52C
T = 0.915T = 0.954
57436721784171438591G/AG = 0.999G = 0.9990.9340.64G
A = 0.001A = 0.001
27357861796371438713A/GA = 0.004A = 0.0040.9351.23G
G = 0.996G = 0.996
57436731801171438761G/AG = 1G = 0.9990.9070.46G
A = 0.000A = 0.001
57436741823871438988A/TA = 1A = 10.9216.24T
T = 0.000T = 0.000
10624521856971439319C/AC = 1C = 0.9980.8620.41C
A = 0.000A = 0.002
57436751867271439422T/CT = 0.003T = 0.0020.9570.79T
C = 0.997C = 0.998
57436761871571439465A/GA = 0.003A = 0.0030.9541.22G
G = 0.997G = 0.997
7602461892771439677C/TC = 0.001C = 0.0010.9950.92C
T = 0.999T = 0.999
113457941926671440016T/—T = 1T = 0.9990.8610.00T
— = 0— = 0.001
57436771929071440040C/TC = 1C = 10.9960.96C
T = 0.000T = 0.000
57436781945671440206T/GT = 0.999T = 0.9990.9951.05G
G = 0.001G = 0.001
145371951171440261C/TC = 0.999C = 10.9261.86T
T = 0.001T = 0.000
31681771957571440325G/AG = 1G = 10.9640.59G
A = 0.000A = 0.000
57436791959171440341G/AG = 1G = 0.9990.9050.42G
A = 0.000A = 0.001
15413041963671440386G/AG = 0.994G = 0.9940.9690.92G
A = 0.006A = 0.006
10537251977071440520A/GA = 0.002A = 0.0010.8670.02A
G = 0.998G = 0.999
57436802000271440752G/AG = 0.001G = 0.0020.9411.82A
A = 0.999A = 0.998
9493242008471440834G/CG = 0.998G = 0.9960.8210.57G
C = 0.002C = 0.004
9493232008671440836A/CA = 0.573A = 0.5550.6130.93A
C = 0.427C = 0.445
57436812024671440996T/CT = 0.005T = 0.0050.9820.92T
C = 0.995C = 0.995
57436822025371441003T/CT = 0.999T = 0.9990.9870.92T
C = 0.001C = 0.001
57436832030071441050G/AG = 0.999G = 10.9331.90A
A = 0.001A = 0.000
57436842053971441289G/AG = 1G = 10.9851.59A
A = 0.000A = 0.000
57436852068271441432C/TC = 0.999C = 0.9980.9270.67C
T = 0.001T = 0.002
28458572077371441523G/CG = 0.603G = 0.6320.4031.13C
C = 0.397C = 0.368
28523652077671441526G/AG = 0.717G = 0.5840.00005570.55G
A = 0.283A = 0.416
115386412090471441654C/AC = 1C = 10.988A
A = 0.000A = 0
115386392091871441668C/TC = 1C = 0.9990.8660.12C
T = 0.000T = 0.001
112354172097871441728A/GA = 0.001A = 0.0020.9421.83G
G = 0.999G = 0.998
115386442126971442019C/AC = 0.992C = 0.9990.7095.16A
A = 0.008A = 0.001
115386432135471442104C/TC = 1C = 0.9990.860.10C
T = 0.000T = 0.001
28458582148871442238T/CT = 0.002T = 0.0010.9690.74T
C = 0.998C = 0.999
21551462165671442406G/TG = 0.985G = 0.9880.8431.25T
T = 0.015T = 0.012
28523642179371442543T/CT = 0.001T = 0.0010.9570.50T
C = 0.999C = 0.999
28458592208471442834A/GA = 0.999A = 0.9990.9911.06G
G = 0.001G = 0.001
28458602221971442969T/CT = 0.998T = 0.9960.7890.51T
C = 0.002C = 0.004
115386422281571443565G/TG = 1G = 10.9862.89T
T = 0.000T = 0.000
79494302285871443608T/CT = 0.003T = 0.0010.7670.20T
C = 0.997C = 0.999
79386742289571443645T/CT = 1T = 0.9990.9820.83T
C = 0.000C = 0.001
27357872343171444181C/TC = 0.976C = 0.9980.32310.97T
T = 0.024T = 0.002
115386402396871444718C/TC = 0.001C = 0.0020.9033.80T
T = 0.999T = 0.998
107367842446971445219T/AT = 1T = 0.9920.6850.11T
A = 0.000A = 0.008
107367852447071445220A/CA = 0.995A = 0.9980.7442.15C
C = 0.005C = 0.002
118260592485371445603T/CT = 1T = 11
C = 0C = 0
25032496171445711T/CT = 0.071T = 0.0410.06580.55T
C = 0.929C = 0.959
21551452517771445927A/CA = 0.994A = 0.9950.8941.36C
C = 0.006C = 0.005
44774592617471446924T/CT = 0.047T = 0.0220.1120.46T
C = 0.953C = 0.978
NUMA1-AA2633471447084T/—T = 0.993T =
— = 0.007— =
50196052633771447087C/GC = 0.996C = 0.9920.8550.49C
G = 0.004G = 0.008
50196042633871447088A/TA = 0.001A =
T = 0.999T =
50196032633971447089C/GC = 0.993C = 0.9930.9790.93C
G = 0.007G = 0.007
37939412696571447715G/AG = 0.551G = 0.5650.6451.06A
A = 0.449A = 0.435
112354182727871448028C/GC = 1C = 10.98G
G = 0.000G = 0
37939402804271448792A/GA = 0.003A = 0.0020.920.62A
G = 0.997G = 0.998
20323532852071449270G/TG = 1G = 0.9990.9370.53G
T = 0.000T = 0.001
39344482853371449283G/TG = 1G = 10.9760.60G
T = 0.000T = 0.000
79512672876471449514A/GA = 0.003A = 0.0020.9450.75A
G = 0.997G = 0.998
10536032968571450435G/AG = 0.999G = 0.9990.9770.84G
A = 0.001A = 0.001
10536023073871451488A/GA = 0.003A = 0.0020.9740.87A
G = 0.997G = 0.998
112354193117571451925T/CT = 0.002T = 0.0020.9571.28C
C = 0.998C = 0.998
10536013149071452240A/GA = 0.002A = 0.0020.9871.12G
G = 0.998G = 0.998
37509133172671452476G/CG = 0.114G = 0.0370.001360.29G
C = 0.886C = 0.963
37509123177071452520A/GA = 0.006A = 0.0030.8250.49A
G = 0.994G = 0.997
10536003179271452542T/AT = 0.001T = 0.0010.9322.89A
A = 0.999A = 0.999
10579923298071453730C/AC = 0.982C = 0.9970.385.78A
A = 0.018A = 0.003
22987893339871454148A/GA = 0.998A = 10.8333.32G
G = 0.002G = 0.000
108988133358071454330T/AT = 0.075T = 0.0490.1740.63T
A = 0.925A = 0.951
NUMA1-AB3494171455691C/TC = 0.098C = 0.0090.000004490.08C
T = 0.902T = 0.991
9493253521471455964G/AG = 0.875G = 0.9320.01081.96A
A = 0.125A = 0.068
NUMA1-AC3562971456379G/CG = 0.061G = 0.0070.0002440.10G
C = 0.939C = 0.993
9493263586471456614T/CT = 0.975T = 0.9890.2332.28C
C = 0.025C = 0.011
22984563627371457023A/TA = 0.89A = 0.9960.000054128.64T
T = 0.110T = 0.004
79498453728171458031A/GA = 0.998A = 0.9980.9951.04G
G = 0.002G = 0.002
79499893737871458128A/GA = 0.036A = 0.030.7640.83A
G = 0.964G = 0.970
15735003834871459098C/GC = 0.172C = 0.1160.02350.63C
G = 0.828G = 0.884
49454113860871459358A/GA = 0.938A = 0.9840.009314.04G
G = 0.062G = 0.016
112354223904971459799C/AC = 1C = 10.9582.79A
A = 0.000A = 0.000
101286583907771459827C/TC = 0.168C = 0.1020.00270.56C
T = 0.832T = 0.898
22984573976971460519T/CT = 0.192T = 0.0890.000008540.41T
C = 0.808C = 0.911
38387794055571461305T/—T = 0.071T = 0.0290.01180.38T
— = 0.929— = 0.971
15735014125171462001T/CT = 0.996T = 0.9960.9251.20C
C = 0.004C = 0.004
112354244127071462020C/TC = 1C = 10.9659.18T
T = 0.000T = 0.000
108988144206371462813T/CT = 0.193T = 0.1080.0003530.50T
C = 0.807C = 0.892
79301424257471463324T/CT = 0.945T = 0.9960.002412.18C
C = 0.055C = 0.004
79305444291271463662C/TC = 0.149C = 0.0820.002240.50C
T = 0.851T = 0.918
79307214303971463789A/CA = 0.759A = 0.8060.1981.31C
C = 0.241C = 0.194
79307224304271463792C/GC = 0.504C = 0.4190.01870.71C
G = 0.496G = 0.581
65924564322171463971A/GA = 0.994A = 0.9970.7341.91G
G = 0.006G = 0.003
112354254351871464268T/CT = 0.001T = 0.0010.9921.17C
C = 0.999C = 0.999
65924574364471464394G/CG = 0.0640G = 0.0410.2160.61G
C = 0.936C = 0.959
108988154498171465731A/GA = 0.578A = 0.5770.981.00A
G = 0.422G = 0.423
112354264501371465763T/CT = 0T = 0.0020.884C
C = 1C = 0.998
108988164503871465788C/TC = 0.999C = 0.9980.9480.77C
T = 0.001T = 0.002
19392474607971466829T/AT = 0.098T = 0.0540.03130.52T
A = 0.902A = 0.946
19392464784871468598T/GT = 1T = 0.9990.9460.65T
G = 0.000G = 0.001
19392454809071468840A/GA = 0.984A = 0.9980.2546.60G
G = 0.016G = 0.002
19392444814771468897G/TG = 0.664G = 0.6350.3470.88G
T = 0.336T = 0.365
19392434829371469043C/TC = 0.073C = 0.0050.001050.06C
T = 0.927T = 0.995
42454634877171469521C/AC = 0.038C = 0.0110.03690.28C
A = 0.962A = 0.989
49442584895171469701A/TA = 0.943A = 0.9940.001848.94T
T = 0.057T = 0.006
79267514997271470722T/GT = 0.103T = 0.0460.002050.42T
G = 0.897G = 0.954
122829175016171470911G/AG = 0.999G = 0.9980.8710.46G
A = 0.001A = 0.002
122829185016371470913G/AG = 0.999G = 0.9960.7920.46G
A = 0.001A = 0.004
79375825017171470921T/CT = 0.992T = 0.9960.6452.05C
C = 0.008C = 0.004
108988175128971472039T/CT = 0.957T = 0.9760.3831.80C
C = 0.043C = 0.024
74800155169971472449G/AG = 0.848G = 0.8410.7710.95G
A = 0.152A = 0.159
71239925200571472755C/TC = 0.083C = 0.0490.05250.56C
T = 0.917T = 0.951
15735025298671473736G/AG = 0.111G = 0.0490.0006640.40G
A = 0.889A = 0.951
71278655333971474089G/CG = 0.146G = 0.0770.001430.49G
C = 0.854C = 0.923
49454265370471474454C/AC = 0.113C = 0.06400.05630.54C
A = 0.887A = 0.936
112354285461571475365G/CG = 1G = 0.9990.920.33G
C = 0.000C = 0.001
71224895530771476057A/CA = 1A = 0.9990.9570.53A
C = 0.000C = 0.001
18940035583471476584T/CT = 0.195T = 0.1180.001120.55T
C = 0.805C = 0.882
15483485647571477225G/AG = 0.977G = 0.9850.511.52A
A = 0.023A = 0.015
18929235705371477803G/AG = 0.022G = 0.0070.4440.28G
A = 0.978A = 0.993
57925705735571478105—/G— = 0— = 0.0010.962G
G = 1G = 0.999
71152005771871478468T/GT = 0.541T = 0.5240.6140.93T
G = 0.459G = 0.476
49454305870371479453G/CG = 0.279G = 0.1910.002330.61G
C = 0.721C = 0.809
112354295877271479522C/TC = 0.001C = 0.0010.9452.60T
T = 0.999T = 0.999
19392425914071479890C/TC = 0.097C = 0.0580.02680.57C
T = 0.903T = 0.942
96663465945071480200G/CG = 0.939G = 0.9580.2511.49C
C = 0.061C = 0.042
71015535946171480211T/CT = 0.999T = 0.9990.9780.84T
C = 0.001C = 0.001
71240005989671480646C/TC = 0.938C = 0.9550.4371.38T
T = 0.062T = 0.045
122916646015771480907G/AG = 0.93G = 0.9580.2131.73A
A = 0.070A = 0.042
122917786036971481119A/GA = 0A = 01
G = 1G = 1
122917816039571481145A/GA = 0.004A = 0.0030.9280.58A
G = 0.996G = 0.997
122917876042471481174G/AG = 0.997G = 0.9980.9791.08A
A = 0.003A = 0.002
122917886042671481176G/AG = 0.998G = 0.9970.9440.81G
A = 0.002A = 0.003
122918336045671481206A/GA = 0.002A = 0.0030.8412.31G
G = 0.998G = 0.997
107930166062171481371G/AG = 0.097G = 0.0540.02190.53G
A = 0.903A = 0.946
57925716120771481957G/—G = 0.202G = 0.1550.05430.72G
— = 0.798— = 0.845
122935296120971481959G/CG = 1G = 10.990.84G
C = 0.000C = 0.000
43385556125471482004C/TC = 0.949C = 0.9790.07332.50T
T = 0.051T = 0.021
112354316185471482604C/GC = 0.003C = 0.0040.9721.10G
G = 0.997G = 0.996
65924586310371483853A/GA = 0.986A = 0.9950.6012.43G
G = 0.014G = 0.005
49454346464571485395C/TC = 0.14C = 0.0830.00630.55C
T = 0.860T = 0.917
49454356477771485527T/CT = 0.998T = 0.9960.8530.55T
C = 0.002C = 0.004
113076576498071485730T/—T = 0.018T = 0.0090.7240.51T
— = 0.982— = 0.991
57925736498771485737T/—T = 0.037T = 0.010.3060.24T
— = 0.963— = 0.990
18940046537571486125T/CT = 0.977T = 0.9840.5371.43C
C = 0.023C = 0.016
122761646556171486311A/GA = 0.004A = 0.0020.8260.50A
G = 0.996G = 0.998
43784216755471488304C/TC = 0.996C = 0.9960.9590.90C
T = 0.004T = 0.004
71164956764371488393C/TC = 0C =
T = 1T =
71017016771371488463A/GA = 0.483A =
G = 0.517G =
107367866883271489582T/CT = 0.959T = 0.9910.1644.57C
C = 0.041C = 0.009
116081657018471490934T/GT = 1T = 10.9620.28T
G = 0.000G = 0.000
6456037041571491165G/AG = 0.967G = 0.970.8291.10A
A = 0.033A = 0.030
6612907157271492322A/GA = 0.186A = 0.1710.6480.90A
G = 0.814G = 0.829
71222097173271492482T/CT = 1T = 10.9942.26C
C = 0.000C = 0.000
124174717282971493579A/GA = 0.125A = 0.1180.7410.94A
G = 0.875G = 0.882
5412287315471493904C/GC = 0.994C = 0.9960.9351.29G
G = 0.006G = 0.004
122736667322171493971A/GA = 0.058A = 0.0470.5110.81A
G = 0.942G = 0.953
25110747434371495093T/CT = 0.946T = 0.9750.1762.19C
C = 0.054C = 0.025
30183117446271495212T/GT = 0.969T = 0.9930.1514.57G
G = 0.031G = 0.007
30182897447171495221T/CT = 0.086T = 0.0690.3750.78T
C = 0.914C = 0.931
6799267549471496244A/GA = 0.923A = 0.9530.08311.70G
G = 0.077G = 0.047
5670267551071496260G/AG = 0.943G = 0.9540.5131.24A
A = 0.057A = 0.046
5642947582771496577G/AG = 1G = 10.9881.14A
A = 0.000A = 0.000
6781937583171496581T/GT = 0.133T = 0.0820.01890.58T
G = 0.867G = 0.918
6772797602771496777T/CT = 0.979T = 0.9880.4771.79C
C = 0.021C = 0.012
5607777616071496910C/TC = 0.925C = 0.960.03411.94T
T = 0.075T = 0.040
6767217619671496946C/TC = 0.105C = 0.0530.004680.47C
T = 0.895T = 0.947
71065297637871497128A/TA = 0.999A = 0.9890.5260.11A
T = 0.001T = 0.011
116023047730671498056G/AG = 0.999G = 0.9990.9910.93G
A = 0.001A = 0.001
5852287884771499597C/GC = 0.158C = 0.0880.001040.51C
G = 0.842G = 0.912
5789577891871499668C/AC = 0.003C = 0.0030.9670.88C
A = 0.997A = 0.997
71102157911771499867A/GA = 0.243A = 0.250.8261.04G
G = 0.757G = 0.750
31332337981171500561C/GC = 0C = 0.0030.842G
G = 1G = 0.997
31332307984371500593T/CT = 0.924T = 0.9460.2521.42C
C = 0.076C = 0.054
125760248044871501198G/TG = 1G = 10.9920.88G
T = 0.000T = 0.000
6743198094971501699C/TC = 0.962C = 0.9690.6181.24T
T = 0.038T = 0.031
6751858113071501880T/GT = 0.237T = 0.1430.001790.54T
G = 0.763G = 0.857
57925748145271502202—/C— = 0.093— = 0.0440.04670.45—
C = 0.907C = 0.956
122752728259571503345C/TC = 0.999C = 10.9561.60T
T = 0.001T = 0.000
104003278363371504383C/TC = 0.001C = 0.00111.01
T = 0.999T = 0.999
6122558422271504972C/TC = 0.977C = 0.9870.3761.74T
T = 0.023T = 0.013
71016438437871505128G/AG = 1G = 0.9990.8870.00G
A = 0A = 0.001
5758718438071505130A/GA = 0.078A = 0.0690.6190.88A
G = 0.922G = 0.931
5472088522671505976C/TC = 0.952C = 0.9650.4791.38T
T = 0.048T = 0.035
25110758581571506565T/CT = 0.112T = 0.0550.02830.46T
C = 0.888C = 0.945
6425738641271507162C/GC = 0.95C = 0.9760.05892.14G
G = 0.050G = 0.024
4821978680571507555G/AG = 0.982G = 0.9910.4031.98A
A = 0.018A = 0.009
6566408726871508018T/CT = 0.391T = 0.3480.1940.83T
C = 0.609C = 0.652
6716818837071509120C/TC = 0.929C = 0.9580.07471.75T
T = 0.071T = 0.042
5410228861471509364A/GA = 0.929A = 0.9640.03791.99G
G = 0.071G = 0.036
9515868922371509973A/GA = 0.003A = 0.0020.860.46A
G = 0.997G = 0.998
25110768938571510135G/AG = 0.778G = 0.7420.2630.82G
A = 0.222A = 0.258
112354328950071510250G/CG = 0.997G = 0.9970.9810.94G
C = 0.003C = 0.003
30183088950271510252T/CT = 0.629T = 0.6330.8981.02C
C = 0.371C = 0.367
116067988992971510679G/CG = 0.997G = 0.9940.7680.58G
C = 0.003C = 0.006
17915449051571511265C/TC = 0.102C = 0.0510.0110.48C
T = 0.898T = 0.949
30183049065971511409C/AC = 0.996C = 0.9940.8380.70C
A = 0.004A = 0.006
107511939091471511664A/CA = 0.738A = 0.7080.3810.86A
C = 0.262C = 0.292
49454709159471512344C/TC = 0.999C = 0.9990.9470.68C
T = 0.001T = 0.001
30182919160371512353A/CA = 0.994A = 0.9990.6833.72C
C = 0.006C = 0.001
25111209176971512519A/GA = 0.989A = 0.9970.4933.26G
G = 0.011G = 0.003
6711329200571512755G/AG = 0.043G = 0.0410.8980.95G
A = 0.957A = 0.959
49454759333571514085G/CG = 0.998G = 0.9990.9221.79C
C = 0.002C = 0.001
30182929344371514193T/GT = 1T = 10.9931.38G
G = 0.000G = 0.000
6426189375171514501C/TC = 0.1C = 0.0510.005940.48C
T = 0.900T = 0.949
5529669377571514525A/CA = 0.159A = 0.0980.00960.57A
C = 0.841C = 0.902
65924599435171515101T/GT = 0.003T = 0.0040.9031.63G
G = 0.997G = 0.996
6074469481071515560C/TC = 0.142C = 0.0840.006110.55C
T = 0.858T = 0.916
6070709485671515606A/GA = 0A = 0.0010.972G
G = 1G = 0.999
107133079589371516643C/—C = 0.662C =
— = 0.338— =
30183029650071517250T/GT = 0.233T = 0.1740.03390.69T
G = 0.767G = 0.826
37509099758771518337G/CG = 0.998G = 0.9980.9860.93G
C = 0.002C = 0.002
30183019762971518379A/GA = 0.268A = 0.1670.0002110.55A
G = 0.732G = 0.833
25111149770571518455C/TC = 0.921C = 0.9590.02681.99T
T = 0.079T = 0.041
122701669796771518717A/GA =A = 0.193
G =G = 0.807
122702419812671518876G/AG = 0.999G = 0.9990.9480.73G
A = 0.001A = 0.001
116065879842271519172A/GA = 0.999A = 0.9990.9891.06G
G = 0.001G = 0.001
6863409877071519520G/CG = 0.972G = 0.9940.05584.34C
C = 0.028C = 0.006
5489619944571520195G/AG = 0.153G = 0.0930.00910.57G
A = 0.847A = 0.907
5490329946771520217C/AC = 0.002C = 0.0010.9430.56C
A = 0.998A = 0.999
57583110010471520854A/GA = 0.056A = 0.0430.3930.75A
G = 0.944G = 0.957
57587810012171520871A/TA = 0.001A = 00.9480.00A
T = 0.999T = 1
57743510023971520989T/CT = 0.981T = 0.9850.7171.26C
C = 0.019C = 0.015
57932010051271521262G/TG = 0.092G = 0.0480.01510.50G
T = 0.908T = 0.952
49556710104671521796C/TC = 0.11C = 0.0520.02050.44C
T = 0.890T = 0.948
63694610126771522017C/TC = 0.999C = 0.9980.8970.61C
T = 0.001T = 0.002
49306510248771523237A/GA = 0.177A = 0.0960.0007490.49A
G = 0.823G = 0.904
59751310298071523730A/TA = 0.094A = 0.06500.2570.67A
T = 0.906T = 0.935
59883510328571524035T/CT = 0.927T = 0.9570.07011.74C
C = 0.073C = 0.043
1068361410335971524109—/TAGT— = 0.027— = 0.0050.1540.16—
TAGT = 0.973TAGT = 0.995
61000410349771524247T/CT = 0.912T = 0.9550.01192.03C
C = 0.088C = 0.045
61004110352671524276A/GA = 0.127A = 0.070.006190.52A
G = 0.873G = 0.930
67347810466271525412T/CT = 0.842T = 0.8960.01731.61C
C = 0.158C = 0.104
67080210522671525976T/GT = 0.128T = 0.0820.02380.61T
G = 0.872G = 0.918
50504110595071526700T/AT = 0.006T = 0.0030.7660.53T
A = 0.994A = 0.997
251111610771871528468C/TC = 0.107C = 0.0420.01540.37C
T = 0.893T = 0.958
62802510790971528659A/CA = 0.104A = 0.0780.30.73A
C = 0.896C = 0.922
51783710791771528667C/TC = 0.902C = 0.9350.0751.56T
T = 0.098T = 0.065
61500010851071529260T/GT = 0.19T = 0.0860.00003920.40T
G = 0.810G = 0.914
48201310952071530270C/TC = 0.122C = 0.0770.02510.60C
T = 0.878T = 0.923
69339110967671530426T/GT = 1T = 10.981.70G
G = 0.000G = 0.000
251107910971271530462T/CT = 0.934T = 0.9660.03971.99C
C = 0.066C = 0.034
225086611007171530821T/CT = 0.15T = 0.0850.002940.52T
C = 0.850C = 0.915
250886011061071531360A/GA = 0.094A = 0.0720.290.75A
G = 0.906G = 0.928
748326711075771531507A/GA = 0.116A = 0.120.8381.05G
G = 0.884G = 0.880
251107811075871531508G/AG = 0.757G = 0.750.7930.96G
A = 0.243A = 0.250
250885911092371531673T/GT = 1T = 10.987170.03G
G = 0.000G = 0.000
250885811096371531713C/GC = 0.101C = 0.0570.02430.54C
G = 0.899G = 0.943
1123543511124571531995T/GT = 0T = 0.0010.954G
G = 1G = 0.999
1123543611143771532187A/GA = 0A = 0.0020.89G
G = 1G = 0.998
63943511217471532924A/CA = 1A = 10.9590.15A
C = 0.000C = 0.000
1228562411264671533396A/GA = 0.505A = 0.510.8571.02G
G = 0.495G = 0.490
NUMA1-AD11278471533534G/TG = 0.005G = 0.0040.9080.79G
T = 0.995T = 0.996
62436311327571534025T/CT = 0.002T = 0.0020.9951.06C
C = 0.998C = 0.998
NUMA1-AE11361471534364T/CT = 0.574T = 0.5830.7791.04C
C = 0.426C = 0.417
105357311396571534715G/TG = 0.001G = 00.9340.00G
T = 0.999T = 1
105351111409571534845C/TC = 1C = 111.00
T = 0.000T = 0.000
106386311412571534875G/AG = 1G = 10.9720.61G
A = 0.000A = 0.000
1213711421371534963C/TC = 0.995C = 0.990.6240.55C
T = 0.005T = 0.010
436508111427871535028A/GA = 0.002A = 0.0020.9831.16G
G = 0.998G = 0.998
446686811432171535071G/CG = 0.999G = 10.898C
C = 0.001C = 0
375091111446571535215A/GA = 0.004A = 0.0040.9851.06G
G = 0.996G = 0.996
51092511505871535808T/CT = 0.099T = 0.0990.9961.00T
C = 0.901C = 0.901
59506211519371535943A/GA = 0.077A = 0.0590.3020.75A
G = 0.923G = 0.941
105344311543371536183C/TC = 0.997C = 10.7574.73T
T = 0.003T = 0.000
54275211620271536952A/TA = 0.118A = 0.0870.2980.71A
T = 0.882T = 0.913
389757911632871537078T/CT = 0.001T = 0.0010.9851.62C
C = 0.999C = 0.999
1123543711681271537562T/CT = 0.001T = 0.0010.9490.41T
C = 0.999C = 0.999
250885611720171537951C/TC = 0.926C = 0.9390.4481.23T
T = 0.074T = 0.061
579257511756571538315A/—A =A = 0.996
— =— = 0.004
65951311796971538719G/AG = 0.949G = 0.9760.05092.20A
A = 0.051A = 0.024
1089882011815071538900A/GA = 0.685A = 0.6680.5830.93A
G = 0.315G = 0.332
227639712772971548479C/TC = 0.014C = 0.0080.550.57C
T = 0.986T = 0.992
375090812795971548709C/TC = 0.089C = 0.0580.08650.63C
T = 0.911T = 0.942
379393812869171549441C/TC = 0.915C = 0.9480.06981.69T
T = 0.085T = 0.052
60228512908671549836C/GC = 1C = 10.9991.01G
G = 0.000G = 0.000
227639612946371550213G/CG = 0.108G = 0.06400.01880.56G
C = 0.892C = 0.936
227639512990071550650T/CT = 0.001T = 0.0020.9023.67C
C = 0.999C = 0.998
180677813661071557360T/CT = 0.955T = 0.9690.3411.44C
C = 0.045C = 0.031
407339413779771558547A/GA = 0.46A = 0.4220.230.86A
G = 0.540G = 0.578
47154715173771572487G/TG = 0.488G = 0.480.8420.97G
T = 0.512T = 0.520
60613615213071572880A/GA = 0.559A = 0.5350.4470.91A
G = 0.441G = 0.465
60524115233271573082T/CT = 0.005T = 0.0020.7120.35T
C = 0.995C = 0.998
68606315378971574539G/AG = 0.003G = 0.0060.7422.10A
A = 0.997A = 0.994
68574915381371574563T/CT = 0.033T = 0.0380.8371.15C
C = 0.967C = 0.962
53320715384471574594A/CA = 0.923A = 0.9190.8110.94A
C = 0.077C = 0.081
47675318861271609362A/GA = 0.077A = 0.070.710.90A
G = 0.923G = 0.930
NUMA1-AF19114971611899G/TG = 0.963G = 0.9740.3981.46T
T = 0.037T = 0.026
1127871234468-3447271455218{circumflex over ( )}—/— = 0.901— = 0.9540.003212.24GTCAAC
71455222GTCAACGTCAAC =GTCAAC =
0.0990.046
383138738627-3862871459377{circumflex over ( )}CA/—CA = 0.04CA = 0.0130.0670.32CA
71459378— = 0.960— = 0.987
|
FIG. 1D shows proximal SNPs in and around the NUMA1 region for females. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIG. 1D can be determined by consulting Table 30. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.
To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10−8 were truncated at that value.
Finally, the gene or genes present in the loci region of the proximal SNPs as annotated by Locus Link (http address: www.ncbi.nlm.nih.gov/LocusLink/) are provided on the graph. The exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.
Additional Genotyping
Three additional NUMA1 region SNPs were genotyped in the discovery cohort. The discovery cohort is described in Example 1. The three SNPs (rs1894003, rs675185, and rs615000) map to the following respective locations within the NUMA1 region: 3'UTR of LOC220074, intron of NUMA1, and intron of LOC220074. All three of the SNPs (rs1894003, rs675185, and rs615000) were found to be significantly associated with breast cancer with a p-value of 0.00833, 0.0465 and 0.00648, respectively. See Table 26.
The methods used to verify and genotype the three proximal SNPs of Table 26 are the same methods described in Examples 1 and 2 herein. The PCR primers and extend primers used in these assays are provided in Table 24 and Table 25, respectively.
TABLE 31
|
|
dbSNP rs#Forward PCR primerReverse PCR primer
|
|
1894003ACGTTGGATGGCCTAGCCATGATTTCCTACACGTTGGATGTTGACCCTCTGGTCCTGC
|
675185ACGTTGGATGCCCGTCTCTGGGGAAAAAAAACGTTGGATGCCCAGCCTATATCCTGCTTT
|
615000ACGTTGGATGATTTTGGCAACTTAGAAGTCACGTTGGATGGCCTCCATTCACTCTTGAAC
|
TABLE 32
|
|
|
dbSNP rs#
Extend Primer
Term Mix
|
|
1894003
TGTAAACCACCTGCTCAGAC
ACT
|
|
675185
ATGGGGAAATACTCAAGAAA
CT
|
|
615000
CCTGGAGGCAGAAGCCAGAT
ACT
|
|
Table 26, below, shows the case and control allele frequencies along with the p-values for additional SNPs genotyped. The disease associated allele of column 4 is in bold. The chromosome positions provided correspond to NCBI's Build 34.
TABLE 33
|
|
Genotyping Results
Position inAmino
SEQ IDChromosomeAllelesAcidAF FOddsBreast Cancer
dbSNP rs#NO: 4Position(A1/A2)ChangeAF F casecontrolp-valueRatioAssoc. Allele
|
18940035583471476584T/CT = 0.086T = 0.0450.008330.504T
C = 0.914C = 0.955
6751858113071501880T/GT = 0.076T = 0.0460.04650.587T
G = 0.924G = 0.954
61500010851071529260T/GT = 0.085T = 0.0430.006480.486T
G = 0.915G = 0.957
|
Example 8
Meta Analysis of Incident SNPs
Meta-analysis was performed of five of the incident SNPs disclosed in Table 3 (ICAM region (ICAM_SNP), MAPK10 (rs1541998), KIAA0861 (rs2001449), NUMA1 region (rs673478) and GALE region (rs4237)) based on genotype results provided in Table 6B. FIGS. 2A-2D depict odds ratios for the discovery samples and replication samples (see Example 3) individually, and the combined meta analysis odds ratio for the named SNP. The boxes are centered over the odds ratio for each sample, with the size of the box correlated to the contribution of each sample to the combined meta analysis odds ratio. The lines extending from each box are the 95% confidence interval values. The diamond is centered over the combined meta analysis odds ratio with the ends of the diamond depicting the 95% confidence interval values. The meta-analysis further illustrates the strong association each of the incident SNPs has with breast cancer across multiple case and control samples.
The subjects available for discovery from Germany included 272 cases and 276 controls. The subjects available for replication from Australia included 190 breast cancer cases and 190 controls. Meta analyses, combining the results of the German discovery sample and the Australian replication sample, were carried out using a random effects (DerSimonian-Laird) procedure.
Example 9
Description of development of predictive breast cancer models
The five SNPs reported in Example 3 were identified as being significantly associated with breast cancer according to the replication analysis discussed therein. These five SNPs are a subset of the panel of SNPs associated with breast cancer in the German chort referenced in Example 1 and reported in provisional patent application No. 60/429,136 filed Nov. 25, 2002 and provisional patent application No. 60/490,234 filed Jul. 24, 2003, having attorney docket number 524593004100 and 524593004101, respectively.
The clinical importance of these SNPs was estimated by combining them into a single logistic regression model. The coefficients of the model were used to estimate penetrance, relative risk and odds ratio values for estimating a subject's risk of having or developing breast cancer according to the subject's genotype. Penetrance is a probability that an individual has or will have breast cancer given their genotype (e.g., a value of 0.01 in the tables is equal to a 1% chance of having or developing breast cancer). The relative risk of breast cancer is based upon penetrance values, and is expressed in two forms. One form, noted as RR in the tables below, is expressed as a risk with respect to the lowest risk group (e.g., the most protected group being the 00000 genotype listed in Table 33). The other form is expressed as a risk with respect to a population average risk of breast cancer, which is noted as RR(Pop) in Table 35 below. Both of these expressions of relative risk are useful to a clinician for assessing risk of breast cancer in an individual and targeting appropriate detection, prevention and/or treatment regimens to the subject. Both expressions of relative risk also are useful to an insurance company to assess population risks of breast cancer (e.g., for developing actuarial tables), where individual genotypes often are provided to the company on an anonymous basis. Odds ratios are the odds one group has or will develop breast cancer with respect to another group, the other group often being the most protective group or the group having a population average risk of breast cancer. Relative risk often is a more reliable assessment of risk in comparison to an odds ratio when the disease or condition at issue is more prevalent.
To fit the single logistic model, all cases and controls from the German and Australian samples were used (see Examples 1 and 3, respectively). Controls were coded as 0 and cases were coded as 1. Based on the genotype penetrance estimates of each SNP (Table 31), GP01.025495354 (rs4237), GP03.197942797 (rs2001449), GP11.079035103 (rs673478) were modeled as additive by coding the genotypes 0, 1, or 2 for the low risk homozygote, the heterozygote, or high risk homozygote, respectively. The SNP FCH.0994 (ICAM_SNP1) was modeled as recessive coding the genotypes 0, 0, or 2 for the low risk homozygote, heterozygote, or high risk homozygote, respectively. The SNP GP04.091348915 (rs1541998) was modeled as dominant coding the genotypes 0, 2, or 2 for the low risk homozygote, the heterozygote, or high risk homozygote, respectively. Table 31 summarizes this analysis.
TABLE 31
|
|
SNP:CaseControlP(D|G)
GenotypeN(N = 254)(N = 268)(%)P-value
|
|
ICAM_SNP1:
CC49745%(103)32%(85)4.1400.006210
CT42%(98)47%(126)2.700
TT13%(30)21%(13)1.910
rs4237:
AA49434%(79)29%(75)3.5500.186000
AG49%(113)48%(126)3.040
GG17%(40)23%(61)2.240
rs2001449:
GG50846%(112)60%(158)2.2800.002930
GC48%(117)36%(94)3.940
CC7%(17)4%(10)5.300
rs673478:
TT50984%(206)91%(240)2.8000.040700
TC14%(35)9%(25)4.490
CC1%(3)0%(0)100.00
rs1541998:
CC4935%(12)4%(10)3.7100.012100
CT36%(87)24%(61)4.370
TT59%(143)72%(180)2.490
|
Based on this coding, there are a total of 108 unique genotype codes from the 243 unique five SNP genotypes. The relationship between the five SNP genotypes and the case-control status was fit using logistic regression. Many models were fit and compared including the five SNPs and all possible interaction among SNPs and study center. Only statistically significant terms from this complete model were included in the final model, shown in Table 32.
TABLE 32
|
|
EstimateStd. Errorz valuePr(>|z|)
|
|
(Intercept)−1.344460.25972−5.1772.26e−07
FCH.09940.776070.198353.9139.13e−05
42370.545250.176663.0860.002025
20014490.603830.284872.1200.034033
15419980.220510.078492.8090.004963
6734780.599610.217372.7580.005807
FCH.0994c: 4237−0.526360.14516−3.6260.000288
FCH.0994c: 2001449−0.356130.24503−1.4530.146113
4237c: 2001449−0.156850.20191−0.7770.437257
FCH.0994c: 4237c20014490.413050.183912.2460.024705
|
Null deviance: 1136.7 on 820 degrees of freedom
Residual deviance: 1069.6 on 811 degrees of freedom
AIC: 1089.6
The penetrance was calculated for each of the 108 unique genotype codes using this model and an assumed disease prevalence of 0.03 (prev), the cumulative incidence for the age range of the sample in question. This was calculated from the logistic model as follows:
penetrance=exp(y+adj)/(1+exp(y+adj))
- where
- y=1/(1+exp(−1.344+0.776*A+0.545*B+0.604*C+0.221*D+0.600*E−0.526*A*B−0.356*A*C-0.157*B*C+0.413*A*B*C))=
- and
- adj=1n(prev/(1−prev)*freq(case)/(1−freq(case)).
Here A, B, C, D, and E refer to the genotype codes for the SNPs FCH.0994, 4237, 2001449, 1541998, and 673478, respectively.
Table 33 summarizes statistics of interest for each genotype code. “Geno” shows each genotype code with the five integer codes formatted as an integer string. “N Case” and “N Control” is the number of cases and controls with the specified code, respectively. “Frequency” is the expected percent of individuals in the population having that code calculated as the average of the case and control frequencies weighted by the probability of disease in this sample (0.03). “OR” is the odds ratio comparing the odds of the specified code to the odds of the most protective code (00000) using the parameter estimates from the logistic regression model. “OR (Frq)” is an odds ratio estimated using the frequency of cases and control with the specified genotype code and the most protective code. “RR” is the relative risk comparing the probability of disease of the specified code to the probability of disease of the most protective code. “Penetrance” is the probability of disease given the genotype code, followed by “Lower” and “Upper” which give the 95% confidence interval for the penetrance. As can be seen by the ratios for OR and RR, the 00000 genotype was the most protective against breast cancer occurrence.
TABLE 33
|
|
Confidence Interval
GenoN CaseN ControlFrequencyOROR (Frq)RRPenetranceLowerUpper
|
000006265.94%1.001.001.000.0100.0070.014
00001030.68%1.750.001.740.0170.0110.029
00002000.00%3.083.010.0300.0130.069
00020392.06%1.611.441.600.0160.0110.023
00021030.68%2.830.002.780.0280.0170.047
00022000.00%4.974.780.0480.0210.108
001009204.60%1.671.951.660.0170.0120.023
00101210.24%2.938.672.870.0290.0180.047
00102000.00%5.134.930.0500.0220.110
00120761.41%2.695.062.650.0270.0180.038
00121000.00%4.734.560.0460.0280.075
00122000.00%8.297.720.0780.0340.168
00200140.91%2.781.082.740.0270.0180.042
00201000.00%4.884.700.0470.0270.082
00202000.00%8.577.960.0800.0340.178
00220110.23%4.504.334.340.0440.0270.070
00221100.01%7.897.380.0740.0410.129
00222000.00%13.8312.250.1230.0520.263
01000244710.84%1.262.211.260.0130.0100.016
01001310.25%2.2113.002.180.0220.0140.034
01002000.00%3.873.770.0380.0170.083
0102018225.12%2.033.552.010.0200.0150.027
01021440.94%3.574.333.480.0350.0220.055
01022000.00%6.265.940.0600.0270.129
0110021337.64%2.102.762.080.0210.0170.026
01101240.92%3.692.173.590.0360.0240.055
01102000.00%6.476.130.0620.0280.130
011201561.47%3.3910.833.310.0330.0250.045
01121000.00%5.955.670.0570.0360.089
01122000.00%10.449.540.0960.0440.198
01200540.94%3.515.423.420.0340.0230.050
01201010.23%6.150.005.850.0590.0350.097
01202000.00%10.799.820.0990.0440.209
01220100.01%5.665.410.0540.0350.083
01221000.00%9.939.120.0920.0540.152
01222000.00%17.4214.950.1500.0670.304
0200022399.01%1.592.441.580.0160.0120.021
02001210.24%2.788.672.730.0270.0170.043
02002100.01%4.884.700.0470.0210.103
0202016102.39%2.566.932.520.0250.0180.035
02021220.47%4.494.334.340.0440.0270.070
02022200.02%7.887.370.0740.0330.158
0210021184.24%2.655.062.600.0260.0200.035
02101530.72%4.647.224.480.0450.0290.070
02102000.00%8.147.600.0760.0350.160
021201181.90%4.285.964.140.0420.0300.058
02121100.01%7.507.040.0710.0440.112
02122000.00%13.1511.720.1180.0540.239
02200440.94%4.424.334.270.0430.0280.065
02201310.25%7.7513.007.260.0730.0430.121
02202000.00%13.5912.060.1210.0530.252
02220210.24%7.138.676.720.0680.0430.106
02221000.00%12.5111.210.1130.0650.189
02222000.00%21.9418.130.1820.0820.358
20000961.43%1.586.501.570.0160.0110.023
20001000.00%2.762.720.0270.0160.045
20002000.00%4.854.670.0470.0200.105
20020840.97%2.548.672.510.0250.0170.037
20021000.00%4.464.310.0430.0260.072
20022000.00%7.837.330.0740.0320.161
20100561.40%2.633.612.590.0260.0180.037
20101410.26%4.6117.334.450.0450.0270.072
20102000.00%8.097.550.0760.0330.163
20120410.26%4.2517.334.110.0410.0280.060
20121100.01%7.456.990.0700.0420.115
20122000.00%13.0611.650.1170.0520.242
20200010.23%4.390.004.240.0430.0270.066
20201100.01%7.707.210.0720.0410.124
20202000.00%13.5011.990.1210.0520.255
20220000.00%7.096.680.0670.0410.108
20221000.00%12.4311.150.1120.0630.192
20222000.00%21.8018.030.1810.0800.361
2100022255.83%1.993.811.970.0200.0150.026
21001340.93%3.483.253.400.0340.0220.053
21002100.01%6.115.810.0580.0260.125
2102011143.26%3.213.403.140.0320.0230.043
21021120.46%5.622.175.370.0540.0340.085
21022000.00%9.869.050.0910.0410.190
2110026245.64%3.314.693.240.0330.0250.042
21101120.46%5.812.175.540.0560.0360.085
21102100.01%10.199.330.0940.0430.191
211201661.48%5.3511.565.120.0510.0370.071
21121400.03%9.388.650.0870.0550.135
21122000.00%16.4514.240.1430.0670.281
21200310.25%5.5313.005.290.0530.0360.078
21201300.02%9.698.920.0900.0540.146
21202000.00%17.0014.650.1470.0670.295
21220220.47%8.934.338.270.0830.0530.127
21221100.01%15.6513.650.1370.0810.223
21222000.00%27.4621.690.2180.1010.409
2200013235.31%2.502.452.460.0250.0180.034
22001410.26%4.3917.334.240.0430.0270.068
22002010.23%7.690.007.210.0720.0320.154
220203102.29%4.041.303.920.0390.0270.056
22021100.01%7.086.670.0670.0410.107
22022000.00%12.4211.140.1120.0510.230
221001551.25%4.1713.004.040.0410.0300.055
22101100.01%7.326.880.0690.0440.107
22102000.00%12.8311.470.1150.0530.232
22120351.16%6.742.606.370.0640.0450.091
22121310.25%11.8213.0010.660.1070.0660.168
22122000.00%20.7217.300.1740.0810.333
22200400.03%6.966.570.0660.0430.100
22201000.00%12.2110.970.1100.0650.181
22202000.00%21.4217.770.1790.0810.348
22220410.26%11.2417.3310.190.1020.0640.160
22221000.00%19.7216.600.1670.0970.271
22222000.00%34.5825.860.2600.1220.470
|
To simplify the interpretation of genotype risk, the 243 unique genotypes were divided into five risk classes on the basis of each estimated penetrance. The levels selected for risk class definitions and the resulting assignment of genotypes into five risk classes is shown in Table 34. The frequency percent of each genotype combination is given in parentheses.
TABLE 34
|
|
Class 1Class 2Class 3Class 4Class 5
(0, 0.013](0.013, 0.025](0.025, 0.042](0.042, 0.1](0.1, 1)
|
|
00000(5.94)00001 (0.68)00022 (0.00)00102 (0.00)00222 (0.00)
00020(2.06)00002 (0.00)00121 (0.00)00122 (0.00)01222 (0.00)
01000(10.84)00021 (0.68)00220 (0.23)00201 (0.00)02022 (0.02)
22000(5.31)00100 (4.60)01002 (0.00)00202 (0.00)02122 (0.00)
00101 (0.24)01021 (0.94)00221 (0.01)02202 (0.00)
00120 (1.41)01101 (0.92)01022 (0.00)02221 (0.00)
00200 (0.91)01120 (1.47)01102 (0.00)02222 (0.00)
01001 (0.25)01200 (0.94)01121 (0.00)20002 (0.00)
01020 (5.12)02001 (0.24)01122 (0.00)20022 (0.00)
01100 (7.64)02020 (2.39)01201 (0.23)20122 (0.00)
02000 (9.01)02100 (4.24)01202 (0.00)20222 (0.00)
21000 (5.83)02200 (0.94)01220 (0.01)21102 (0.01)
22001 (0.26)20000 (1.43)01221 (0.00)21122 (0.00)
22020 (2.29)20100 (1.40)02002 (0.01)21201 (0.02)
20200 (0.23)02021 (0.47)21202 (0.00)
20220 (0.00)02101 (0.72)21221 (0.01)
21001 (0.93)02102 (0.00)21222 (0.00)
21020 (3.26)02120 (1.90)22102 (0.00)
21100 (5.64)02121 (0.01)22121 (0.25)
22002 (0.23)02201 (0.25)22122 (0.00)
22021 (0.01)02220 (0.24)22200 (0.03)
22100 (1.25)20001 (0.00)22201 (0.00)
20020 (0.97)22202 (0.00)
20021 (0.00)22220 (0.26)
20101 (0.26)22221 (0.00)
20102 (0.00)22222 (0.00)
20120 (0.26)
20121 (0.01)
20201 (0.01)
20202 (0.00)
20221 (0.00)
21002 (0.01)
21021 (0.46)
21022 (0.00)
21101 (0.46)
21120 (1.48)
21121 (0.03)
21200 (0.25)
21220 (0.47)
22022 (0.00)
22101 (0.01)
22120 (1.16)
|
With this classification, each genotype was recoded as belonging to their respective class and a logistic regression model was fit with the genotype risk class as a categorical variable. Key summary statistics are summarized in Table 35. Each group is described by the number of cases, number of controls, the estimated risk class population frequency, the odds ratio comparing the odds of the given risk class compared to the odds of the lowest risk class, the penetrance, the relative risk (risk class penetrance divided by most protective risk class penetrance), and the population relative risk (risk class penetrance divided by the disease prevalence: 0.03).
TABLE 35
|
|
Risk ClassN CaseN ControlFrequency (%)ORPenetranceRRRR (Pop)
|
|
G14610524.21.00.0121.00.41
G211216838.91.50.0191.50.62
G314011326.72.80.0342.81.13
G477409.74.40.0524.21.73
G51820.0620.50.20416.66.79
|
Example 10
Inhibition of ICAM Gene Expression by Transfection of Specific siRNAs
RNAi-based gene inhibition was selected as a rapid way to inhibit expression of ICAM1 in cultured cells. siRNA reagents were selectively designed to target the ICAM 1 gene. Algorithms useful for designing siRNA molecules specific for an ICAM 1 gene are disclosed at the http address www.dharmacon.com. siRNA molecules up to 21 nucleotides in length were utilized.
Table 31 summarizes the features of the duplexes that were used in the assays to target ICAM1. A non-homologous siRNA reagent (siGL2 control) was used as a negative control, and a non-homologous siRNA reagent (siRNA_RAD21—1175 control) shown to inhibit the expression of RAD21 and subsequently inhibit cell proliferation was used as a positive control in all of the assays described herein.
TABLE 36
|
|
siRNAsiRNA TargetSequence SpecificitySEQ ID NO:
|
ICAM1_293ICAM1ACAACCGGAAGGUGUAUGA
|
ICAM1_335ICAM1GCCAACCAAUGUGCUAUUC
|
ICAM1_604ICAM1GAUCACCAUGGAGCCAAUU
|
ICAM1_1409ICAM1CUGUCACUCGAGAUCUUGA
|
siRNA_RAD21_1175RAD21GAGUUGGAUAGCAAGACAA
positive control
|
siGL2 negativeGL2CGUACGCGGAAUACUUCGA
control
|
The siRNAs were transfected in cell lines MCF-7 and T-47D using Lipofectamine™ 2000 reagent from Invitrogen, Corp. 2.5 μg or 5.0 μg of siRNA was mixed with 6.25 μl or 12.5 μl lipofectamine, respectively, and the mixture was added to cells grown in 6-well plates. Their inhibitory effects on ICAM 1 gene expression were confirmed by precision expression analysis by MassARRAY (quantitativeRT-PCR hME), which was performed on RNA prepared from the transfected cells. See Chunming & Cantor, PNAS 100(6): 3059-3064 (2003). Cell viability was measured at 1, 2, 4 and 6 days post-transfection. Absorbance values were normalized relative to Day 1. RNA was extracted with Trizole reagent as recommended by the manufacturer (Invitrogen, Corp.) followed by cDNA synthesis using SuperScript™ reverse transcriptase.
A cocktail of siRNA molecules described in Table 28 (that target ICAM1) strongly inhibited proliferation of breast cancer cell line (MCF-7), as shown in FIG. 3. These effects are consistent in all six experiments performed. Each data point is an average of 3 wells of a 96-well plate normalized to values obtained from day 1 post transfection. The specificity of the active siRNAs, was confirmed with a negative, non-homologous control siRNA (siGL2), and a positive control, siRNA_RAD21—1175, that targets a known cancer-associated gene, RAD21. Long term inhibition of gene expression is desirable in certain cases. Therefore, included herein are embodiments directed to siRNA duplexes described herein (see Table 36) that are less susceptible to degradation. An example of a modification that decreases susceptibility to degradation is in siSTABLE RNA described at http address www.dharmacon.com.
Example 11
In Vitro Production of Target Polypeptides
- cDNA is cloned into a pIVEX 2.3-MCS vector (Roche Biochem) using a directional cloning method. A cDNA insert is prepared using PCR with forward and reverse primers having 5′ restriction site tags (in frame) and 5-6 additional nucleotides in addition to 3′ gene-specific portions, the latter of which is typically about twenty to about twenty-five base pairs in length. A Sal I restriction site is introduced by the forward primer and a Sma I restriction site is introduced by the reverse primer. The ends of PCR products are cut with the corresponding restriction enzymes (i.e., Sal I and Sma I) and the products are gel-purified. The pIVEX 2.3-MCS vector is linearized using the same restriction enzymes, and the fragment with the correct sized fragment is isolated by gel-purification. Purified PCR product is ligated into the linearized pIVEX 2.3-MCS vector and E. coli cells transformed for plasmid amplification. The newly constructed expression vector is verified by restriction mapping and used for protein production.
E. coli lysate is reconstituted with 0.25 ml of Reconstitution Buffer, the Reaction Mix is reconstituted with 0.8 ml of Reconstitution Buffer; the Feeding Mix is reconstituted with 10.5 ml of Reconstitution Buffer; and the Energy Mix is reconstituted with 0.6 ml of Reconstitution Buffer. 0.5 ml of the Energy Mix was added to the Feeding Mix to obtain the Feeding Solution. 0.75 ml of Reaction Mix, 50 μl of Energy Mix, and 10 μg of the template DNA is added to the E. coli lysate.
Using the reaction device (Roche Biochem), 1 ml of the Reaction Solution is loaded into the reaction compartment. The reaction device is turned upside-down and 10 ml of the Feeding Solution is loaded into the feeding compartment. All lids are closed and the reaction device is loaded into the RTS500 instrument. The instrument is run at 30° C. for 24 hours with a stir bar speed of 150 rpm. The pIVEX 2.3 MCS vector includes a nucleotide sequence that encodes six consecutive histidine amino acids on the C-terminal end of the target polypeptide for the purpose of protein purification. Target polypeptide is purified by contacting the contents of reaction device with resin modified with Ni2+ ions. Target polypeptide is eluted from the resin with a solution containing free Ni2+ ions.
Example 12
Cellular Production of Target Polypeptides
Nucleic acids are cloned into DNA plasmids having phage recombination cites and target polypeptides are expressed therefrom in a variety of host cells. Alpha phage genomic DNA contains short sequences known as attP sites, and E. coli genomic DNA contains unique, short sequences known as attB sites. These regions share homology, allowing for integration of phage DNA into E. coli via directional, site-specific recombination using the phage protein Int and the E. coli protein IHF. Integration produces two new att sites, L and R, which flank the inserted prophage DNA. Phage excision from E. coli genomic DNA can also be accomplished using these two proteins with the addition of a second phage protein, X is. DNA vectors have been produced where the integration/excision process is modified to allow for the directional integration or excision of a target DNA fragment into a backbone vector in a rapid in vitro reaction (Gateway™ Technology (Invitrogen, Inc.)).
A first step is to transfer the nucleic acid insert into a shuttle vector that contains attL sites surrounding the negative selection gene, ccdB (e.g. pENTER vector, Invitrogen, Inc.). This transfer process is accomplished by digesting the nucleic acid from a DNA vector used for sequencing, and to ligate it into the multicloning site of the shuttle vector, which will place it between the two attL sites while removing the negative selection gene ccdB. A second method is to amplify the nucleic acid by the polymerase chain reaction (PCR) with primers containing attB sites. The amplified fragment then is integrated into the shuttle vector using Int and IHF. A third method is to utilize a topoisomerase-mediated process, in which the nucleic acid is amplified via PCR using gene-specific primers with the 5′ upstream primer containing an additional CACC sequence (e.g., TOPO® expression kit (Invitrogen, Inc.)). In conjunction with Topoisomerase I, the PCR amplified fragment can be cloned into the shuttle vector via the attL sites in the correct orientation.
Once the nucleic acid is transferred into the shuttle vector, it can be cloned into an expression vector having attR sites. Several vectors containing attR sites for expression of target polypeptide as a native polypeptide, N-fusion polypeptide, and C-fusion polypeptides are commercially available (e.g., pDEST (Invitrogen, Inc.)), and any vector can be converted into an expression vector for receiving a nucleic acid from the shuttle vector by introducing an insert having an attR site flanked by an antibiotic resistant gene for selection using the standard methods described above. Transfer of the nucleic acid from the shuttle vector is accomplished by directional recombination using Int, IHF, and X is (LR clonase). Then the desired sequence can be transferred to an expression vector by carrying out a one hour incubation at room temperature with Int, IHF, and X is, a ten minute incubation at 37° C. with proteinase K, transforming bacteria and allowing expression for one hour, and then plating on selective media. Generally, 90% cloning efficiency is achieved by this method. Examples of expression vectors are pDEST 14 bacterial expression vector with att7 promoter, pDEST 15 bacterial expression vector with a T7 promoter and a N-terminal GST tag, pDEST 17 bacterial vector with a T7 promoter and a N-terminal polyhistidine affinity tag, and pDEST 12.2 mammalian expression vector with a CMV promoter and neo resistance gene. These expression vectors or others like them are transformed or transfected into cells for expression of the target polypeptide or polypeptide variants. These expression vectors are often transfected, for example, into murine-transformed a adipocyte cell line 3T3-L1, (ATCC), human embryonic kidney cell line 293, and rat cardiomyocyte cell line H9C2.
Example 13
Haplotype analysis of the KIAA0861 locus
rs6804951 and rs2001449 are significant at the allele and genotype levels (P<0.05). Moderate LD is observed for markers rs3732602 and rs2293203 (r{circumflex over ( )}2=0.646). Chi-squared tests indicate that haplotypes are significantly associated with breast cancer. Cell-specific chi-square values indicate that TTTTG and CTTTC haplotypes are contributors to this relationship. Odds ratios and score tests indicate that individuals carrying the TTTG are less likely to have breast cancer, while individuals with CTTTC are at elevated risk for the disease. Moreover, the odds ratio estimated for the CGTTC indicates more than a two-fold risk of disease among its carriers, although this result must be interpreted with great caution due to the low observed frequency in the population.
Summary Statistics of Alleles and Genotypes
SNP Locations
|
|
SNP. ID
Type
Location
|
|
rs6804951
Proximal
184327431
|
rs7639705
Proximal
184330963
|
rs3732602
Proximal
184408945
|
rs2293203
Proximal
184419992
|
rs2001449
Incident
184429569
|
|
Allele by GYNGroup
|
|
Case
Control
Test
|
N
(N = 544)
(N = 552)
Statistic
|
|
|
rs6804951:T
1064
5%
(24)
9%
(46)
Chi-square = 6.71
|
d.f. = 1 P = 0.00958
|
rs7639705:T
1086
80%
(434)
81%
(441)
Chi-square = 0.03
|
d.f. = 1 P = 0.868
|
rs3732602:T
1074
99%
(532)
99%
(532)
Chi-square = 0.4
|
d.f. = 1 P = 0.529
|
rs2293203:T
1088
99%
(536)
99%
(538)
Chi-square = 0.27
|
d.f. = 1 P = 0.6
|
|rs200144:C
1084
30%
(161)
22%
(119)
Chi-square = 8.49
|
d.f. P = 0.00356
|
|
Genotype by GYNGroup
|
|
Case
Control
Test
|
N
(N = 272)
(N = 276)
Statistic
|
|
|
rs6804951:CC
532
91%
(238)
83%
(225)
Chi-square = 7.13
|
d.f. = 2 P = 0.0283
|
CT
9%
(24)
16%
(44)
|
TT
0%
(0)
0%
(1)
|
rs7639705:GG
543
3%
(9)
5%
(14)
Chi-square = 2.03
|
d.f. = 2 P = 0.362
|
GT
33%
(88)
28%
(77)
|
TT
64%
(173)
67%
(182)
|
rs3732602:TT
537
99%
(264)
98%
(263)
Chi-square = 0.4
|
d.f. = 1 P = 0.527
|
rs2293203:TT
544
98%
(265)
97%
(265)
Chi-square = 0.28
|
d.f. = 1 P = 0.598
|
rs2001449:GG
542
47%
(128)
60%
(162)
Chi-square = 9.29
|
d.f. = 2 P = 0.00961
|
GC
46%
(125)
37%
(99)
|
CC
7%
(18)
4%
(10)
|
|
Genotype OC: Test of Hardy-Weinberg Equilibrium Cases
|
|
A. freqDChiSqPvalue
|
|
rs68049510.936−0.0022800.78700.3750
rs76397050.8070.0047900.51500.4730
rs37326020.990−0.0001010.05650.8120
rs22932030.987−0.0001640.09210.7620
rs20014490.744−0.0145003.14000.0763
|
Controls
|
|
A. freq
D
ChiSq
Pvalue
|
|
|
rs6804951
0.916
−0.003400
0.5350
0.465
|
rs7639705
0.808
−0.014400
2.3600
0.124
|
rs3732602
0.989
0.000120
0.0336
0.855
|
rs2293203
0.985
−0.000213
0.0601
0.806
|
rs2001449
0.783
−0.010700
1.0800
0.299
|
|
Summary Statistics: Linkage Disequilibrium
PHASE Haplotype Frequencies
|
|
H. freq
H. relfreq
|
|
|
CGTTC
13
0.012
|
CGTTG
191
0.175
|
CTCAG
10
0.009
|
CTCTG
1
0.001
|
CTTAG
4
0.004
|
CTTTC
265
0.243
|
CTTTG
538
0.493
|
TGTTG
7
0.006
|
TTTTC
2
0.002
|
TTTTG
61
0.056
|
|
Linkage Disequilibrium Between Markers
r{circumflex over ( )}2
|
|
rs6804951
rs7639705
rs3732602
rs2293203
rs2001449
|
|
|
rs6804951
1.000000
0.00382
0.000697
0.00089
0.01860
|
rs7639705
0.003820
1.00000
0.002440
0.00311
0.04770
|
rs3732602
0.000697
0.00244
1.000000
0.64600
0.00351
|
rs2293203
0.000890
0.00311
0.646000
1.00000
0.00448
|
rs2001449
0.018600
0.04770
0.003510
0.00448
1.00000
|
|
D′
|
|
rs6804951
rs7639705
rs3732602
rs2293203
rs2001449
|
|
|
rs6804951
1.0000
0.116
0.0685
0.0685
0.306
|
rs7639705
0.1160
1.000
0.2400
0.2400
0.262
|
rs3732602
0.0685
0.240
1.0000
0.9080
0.345
|
rs2293203
0.0685
0.240
0.9080
1.0000
0.345
|
rs2001449
0.3060
0.262
0.3450
0.3450
1.000
|
|
P-value
|
|
rs6804951
rs7639705
rs3732602
rs2293203
rs2001449
|
|
|
rs6804951
1.00e+00
4.12e−02
0.3830
0.3240
6.40e−06
|
rs7639705
4.12e−02
1.00e+00
0.1030
0.0653
5.41e−13
|
rs3732602
3.83e−01
1.03e−01
1.0000
0.0000
5.03e−02
|
rs2293203
3.24e−01
6.53e−02
0.0000
1.0000
2.70e−02
|
rs2001449
6.40e−06
5.41e−13
0.0503
0.0270
1.00e+00
|
|
Haplotype by GYNGroup
PHASE Haplotypes (All)
|
|
Case
Case(%)
Case.X{circumflex over ( )}2
Control
Control(%)
Control.X{circumflex over ( )}2
OR
In. OR
|
|
|
TTTTG
20
1.83
3.55
41
3.75
3.53
0.4782
−0.7377
|
CTCAG
4
0.37
0.19
6
0.55
0.19
0.6654
−0.4074
|
TGTTG
3
0.27
0.07
4
0.37
0.07
0.7493
−0.2886
|
CTTTG
259
23.72
0.30
279
25.55
0.30
0.9060
−0.987
|
CGTTG
94
8.61
0.01
97
8.88
0.01
0.9662
−0.0344
|
CTTAG
2
0.18
0.00
2
0.18
0.00
1.0000
0.0000
|
TTTTC
1
0.09
0.00
1
0.09
0.00
1.0000
0.0000
|
CTTTC
151
13.83
2.73
114
10.44
2.71
1.3766
0.3196
|
CGTTC
9
0.82
0.98
4
0.37
0.98
2.2604
0.8155
|
CTCTG
1
0.09
0.51
0
0.00
0.50
Inf
Inf
|
|
Pearson Chi-squared Test = 16.6377, DF = 9, P-value = 0.0547
|
PHASE Haplotypes (Low Frequency Removed)
|
|
Case
Case(%)
Case.X{circumflex over ( )}2
Control
Control(%)
Control.X{circumflex over ( )}2
OR
In.OR
|
|
|
TTTTG
20
1.86
3.55
41
3.80
3.52
0.4781
−0.7379
|
CTCAG
4
0.37
0.19
6
0.56
0.19
0.6654
−0.4074
|
CTTTG
259
24.03
0.30
279
25.88
0.30
0.9056
−0.0992
|
CGTTG
94
8.72
0.01
97
9.00
0.01
0.9661
−0.0345
|
CTTTC
151
14.01
2.73
114
10.58
2.71
1.3774
0.3202
|
CGTTC
9
0.83
0.98
4
0.37
0.98
2.2605
0.8156
|
|
Pearson Chi-squared Test = 15.4946, DF = 5, P-value = 0.008445
|
haplo.score Haplotypes
|
|
Hap. FreqScore P.X{circumflex over ( )}2P. Sim
|
|
TTTTG0.0529−2.12060.03400.0342
TGTTG0.0101−2.06680.03880.0236
CTCAG0.0073−1.29140.19660.2902
CTTTG0.5221−1.22750.21960.2195
CGTTG0.1448−0.14410.88540.8834
CTTTC0.22672.34220.01920.0192
CGTTC0.03072.69940.00690.0050
|
Global Score = 20.343, DF = 7, Global P. X{circumflex over ( )}2 = 0.0049, Global P. Sim = 0.0022
|
Example 14
Haplotype analysis of the NUMA1 locus
All markers noted below except 2276396 are associated with breast cancer at the allele level (P<0.05). Marker 675185 does not maintain this relationship at the genotype level. Strong LD is observed across the entire region but is particular strong between and among 1894003, 675185, 673478, and 615000. Pearson chi-squared statistics suggest that haplotypes are significantly associated with breast cancer. Haplotype TTCTC contributes the most to this relationship. Odds ratios and score statistics indicate that individuals with haplotype TTCTC are 2.6 times more likely to have breast cancer than individuals with other haplotypes.
Statistics
Chi-squared statistics are estimated to assess whether 1) alleles and genotypes are associated with breast cancer status and 2) marker genotype frequencies deviate significantly from Hardy-Weinberg equilibrium (HWE). Haplotype frequencies and relative frequencies are estimated, as well as several statistics (r2, D′, and p-value) that gauge the extent and stability of linkage disequilibrium between markers in each region. Chi-squared statistics and score tests are estimated to determine whether reconstructed haplotypes are significantly associated with breast cancer status (P<0.05). P-values are estimated for 1) the full set of reconstructed haplotypes and 2) a reduced set that excludes haplotypes with observed frequencies less than 10. Results are presented by chromosome order.
Results
Summary Statistics: Alleles and Genotypes
SNP Locations
|
|
SNP. ID
Type
Location
|
|
|
1894003
Proximal
71972974
|
675185
Proximal
71998270
|
673478
Incident
72021802
|
615000
Proximal
72025650
|
2276396
Proximal
72046603
|
|
Allele by GYNGroup
|
|
Case
Control
Test
|
N
(N = 510)
(N-538)
Statistic
|
|
|
1894003:C
1026
91%(450)
96%(510)
Chi-square = 6.95
|
d.f. = 1 P = 0.00838
|
675185:G
1010
92%(451)
95%(498)
Chi-square = 3.96
|
d.f. = 1 P = 0.0466
|
673478:C
1022
8%(41)
5%(25)
Chi-square = 5.68
|
d.f. = 1 P = 0.0171
|
615000:G
1010
92%(434)
96%(513)
Chi-square = 7.4
|
d.f. = 1 P = 0.00652
|
2276396:C
1028
97%(478)
98%(523)
Chi-square = 0.18
|
d.f. = 1 P = 0.674
|
|
Genotype by GYNGroup
|
|
Case
Control
Test
|
N
(N = 255)
(N = 269)
Statistic
|
|
|
1894003:TT
513
1%(3)
0%(0)
Chi-square = 7.43
|
d.f. = 2 P = 0.0243
|
TC
15%(36)
9%(24)
|
CC
84%(207)
91%(243)
|
675185:TT
505
0%(1)
0%(0)
Chi-square = 4.37
|
d.f. = 2 P = 0.112
|
TG
14%(35)
9%(24)
|
GG
85%(208)
91%(237)
|
673478:TT
511
84%(207)
91%(241)
Chi-square = 6.39
|
d.f. = 2 P = 0.0409
|
TC
14%(35)
9%(25)
|
CC
1%(3)
0%(0)
|
615000:TT
505
1%(3)
0%(0)
Chi-square = 7.8
|
d.f. = 2 P = 0.0202
|
TG
14%(34)
9%(23)
|
GG
84%(200)
91%(245)
|
2276396:CC
514
4%(232)
95%(255)
Chi-square = 0.18
|
d.f. = 1 P = 0.67
|
|
Hardy-Weinberg Proportions
All
|
|
A. freq
D
ChiSq
Pvalue
|
|
|
1894003
0.935
0.00159
0.350
0.554
|
675185
0.935
0.00159
0.350
0.554
|
673478
0.935
0.00159
0.350
0.554
|
615000
0.937
0.00184
0.495
0.482
|
2276396
0.974
−0.00069
0.374
0.541
|
|
Control
|
|
A. freq
D
ChiSq
Pvalue
|
|
|
1894003
0.953
−0.002190
0.644
0.422
|
675185
0.953
−0.002190
0.644
0.422
|
673478
0.953
−0.002190
0.644
0.422
|
615000
0.957
−0.001860
0.541
0.462
|
2276396
0.976
−0.000593
0.166
0.683
|
|
Summary Statistics: Linkage Disequilibrium
Haplotype Frequencies
|
|
H. freq
H. relfreq
|
|
|
CGTGC
961
0.935
|
TTCGC
1
0.001
|
TTCGG
1
0.001
|
TTCTC
39
0.038
|
TTCTG
26
0.025
|
|
Linkage Disequilibrium Between Markers
r2
|
|
1894003
675185
GP11.079035103
615000
2276396
|
|
|
1894003
1.000
1.000
1.000
0.968
0.387
|
675185
1.000
1.000
1.000
0.968
0.387
|
673478
1.000
1.000
1.000
0.968
0.387
|
615000
0.968
0.968
0.968
1.000
0.369
|
2276396
0.387
0.387
0.387
0.369
1.000
|
|
D′
|
|
1894003
675185
GP11.079035103
615000
2276396
|
|
|
1894003
1
1
1
1.00
1.00
|
675185
1
1
1
1.00
1.00
|
673478
1
1
1
1.00
1.00
|
615000
1
1
1
1.00
0.96
|
2276396
1
1
1
0.96
1.00
|
|
P-value
|
|
X
1894003
675185
GP11.079035103
615000
2276396
|
|
1894003
1
0
0
0
0
|
675185
0
1
0
0
0
|
GP11.079035103
0
0
1
0
0
|
615000
0
0
0
1
0
|
2276396
0
0
0
0
1
|
|
Haplotype by GYNGroup
PHASE Haplotypes (All)
|
|
Case
Case(%)
Case.X{circumflex over ( )}2
Control
Control(%)
Control.X{circumflex over ( )}2
OR
In.OR
|
|
|
TTCGC
0
0.00
0.48
1
0.10
0.44
0.0000
−Inf
|
TTCGG
0
0.00
0.48
1
0.10
0.44
0.0000
−Inf
|
CGTGC
452
43.97
0.21
509
49.51
0.19
0.8001
−0.2230
|
TTCTG
14
1.36
0.18
12
1.17
0.17
1.1690
0.1561
|
TTCTC
28
2.72
4.57
11
1.07
4.23
2.5887
0.9512
|
|
Pearson Chi-squared Test = 11.4058, DF = 4, P-value = 0.02236
|
Permutation Test P-value = 0.14
|
PHASE Haplotypes (Low Frequency Excluded)
|
|
Case
Case(%)
Case.X{circumflex over ( )}2
Control
Control(%)
Control.X{circumflex over ( )}2
OR
In.OR
|
|
|
CGTGC
452
44.05
0.25
509
49.61
0.23
0.7998
−0.2234
|
TTCTG
14
1.36
0.18
12
1.17
0.16
1.1690
0.1561
|
TTCTC
28
2.73
4.53
11
1.07
4.21
2.5888
0.9512
|
|
Pearson Chi-squared Test = 9.5506, DF = 2, P-value = 0.008435
|
haplo.score Haplotypes
|
|
Hap. Freq
Score
P. X{circumflex over ( )}2
P. Sim
|
|
|
CGTGC
0.9410
−2.0316
0.0422
0.0531
|
TTCTG
0.0248
0.3232
0.7465
0.8344
|
TTCTC
0.0321
2.6973
0.0070
0.0093
|
|
Global Score = 9.1386, DF = 3, Global P. X{circumflex over ( )}2 = 0.0275, Global P. Sim = 0.0212
|
Example 15
GALE Region Proximal SNPs
It has been discovered that a polymorphic variation (rs4237) in the HT014/LOC148902/LYPLA2/GALE region is associated with the occurrence of breast cancer (see Examples 1 and 2). Subsequently, SNPs proximal to the incident SNP (rs4237) were identified and allelotyped in breast cancer sample sets and control sample sets as described in Examples 1 and 2. Approximately 175 allelic variants located within the HT014/LOC148902/LYPLA2/GALE region were identified and allelotyped. The polymorphic variants are set forth in Table 37. The chromosome position provided in column four of Table 37 is based on Genome “Build 34” of NCBI's GenBank.
TABLE 37
|
|
Position inChromosomeAlleleGenomeDeduced
dbSNP rs#SEQ ID NO: 5ChromosomePositionVariantsLetterIupac
|
|
627451215123536215g/agR
12082331385123536385g/cgS
22679602019123538019t/ctY
75196403112123539112c/ggS
120867413437123539437g/agR
39341894326123540326t/ctY
121354154523123540523a/gaR
120882674645123540645a/ggR
120846654646123540646c/ttY
5508505830123541830t/ccY
5572276556123542556g/tgK
121375026568123542568t/aaW
121188586570123542570c/tcY
22944959351123545351c/tcY
1240165010874123546874c/tcY
223554110926123546926c/tcY
52071311462123547462g/agR
55025212415123548415t/ccY
HT014-AA12668123548668a/ggR
1209368313886123549886g/cgS
1091742115005123551005g/agR
274487315387123551387a/ttW
1209176415639123551639g/aaR
HT014-AB15761123551761a/ttW
207634516969123552969c/tcY
207634617124123553124t/ctY
247337917369123553369a/gaR
667930017523123553523c/ggS
1181139518158123554158t/atW
817946718220123554220t/aaW
817946818224123554224t/aaW
1091742318538123554538a/ggR
753669918810123554810g/cgS
321549720282123556282—/ttN
100021320495123556495c/atK
100021220633123556633c/tgR
100021120659123556659g/acY
104501721603123557603a/ggR
1205952024075123560075c/ggS
214311824191123560191c/tcY
1212680425010123561010t/ccY
53327625124123561124c/tcY
1240217425145123561145g/cgS
286411025222123561222c/atK
1158187325288123561288t/ccY
1206244926080123562080g/agR
1203319026556123562556c/tcY
1015756627416123563416t/ctY
48674627432123563432c/gcS
1180270729841123565841a/ggR
666855029955123565955c/aaM
741094630160123566160a/ggR
741097030294123566294g/cgS
665755831039123567039c/ggS
214311932071123568071t/ccY
751439433698123569698t/ccY
1159120235555123571555a/caM
667399136658123572658a/gaR
HT014-AC37720123573720g/ccS
1203484838304123574304c/tcY
250298439008123575008t/ctY
383191039985123575985a/—aN
1137944439989123575989—/ttN
72511940683123576683t/aaW
1091742542158123578158t/ccY
1207778844369123580369c/gcS
1207783044503123580503c/gcS
247338045382123581382c/ttY
247338146171123582171a/caM
1154513247276123583276g/tgK
104692447299123583299t/ctY
423747604123583604a/ggR
437531748462123584462g/agR
1158422050786123586786a/ccM
223297551057123587057g/tgK
250298551310123587310g/agR
383542351996123587996c/—gN
223297652546123588546t/atK
223297752602123588602c/tcY
223297852725123588725g/agR
223297952858123588858a/ccM
223298052935123588935t/ggK
223298152948123588948c/tcY
223298253102123589102t/ccY
223298354160123590160c/acM
223298454794123590794c/tcY
223298554798123590798t/ccY
223298654853123590853t/ccY
274555422123591422a/gcY
274455460123591460c/ggS
1154612755645123591645g/tgK
104998855660123591660t/cgR
180361355729123591729c/tgR
180361255736123591736t/gcM
HT014-AD55821123591821t/ccY
320997355970123591970t/gcM
318054556150123592150c/acM
318038356167123592167a/ggR
317781456171123592171g/tgK
318054656210123592210g/ttK
318054756213123592213a/ccM
1180539856259123592259t/ggK
76094156461123592461t/ccY
317781356480123592480t/ccY
318054856486123592486a/ggR
317986456499123592499a/ggR
317781256510123592510t/ccY
317986356543123592543g/tgK
669210456827123592827g/cgS
318054956846123592846g/ccS
317986256859123592859c/acM
317781156870123592870g/ccS
317781056890123592890c/acM
318038256907123592907a/ccM
1154612657767123593767c/taR
755138458774123594774c/ggS
1214151159444123595444t/ccY
247338259452123595452g/agR
1203816659753123595753a/ggR
666690860766123596766c/acM
1204115961135123597135g/ccS
1203159261339123597339a/caM
106259861922123597922c/tgR
1171461942123597942c/tcY
320359361958123597958a/gcY
104243662068123598068t/cgR
207634362601123598601a/gaR
1213153962661123598661g/agR
1158393562882123598882t/ggK
1214026363949123599949a/ccM
383522564732123600732—/aggN
247337465145123601145c/ttY
225617965780123601780a/ggR
97469866260123602260c/tcY
101839667087123603087c/tgR
71939967937123603937g/acY
71940068196123604196g/atY
250298668767123604767g/tgK
667937869482123605482t/ccY
247337570020123606020c/tcY
247337672759123608759a/ggR
1213645572911123608911g/cgS
250298773331123609331c/aaM
1155176774250123610250c/tgR
1159120574486123610486t/ccY
1208329874921123610921a/taW
1213860475065123611065g/agR
1213604275077123611077c/ttY
1213860675078123611078g/agR
1213604575096123611096c/ttY
1211659675108123611108c/gcS
1213861075121123611121a/ggR
1213606975136123611136t/ctY
1211661775150123611150c/tcY
754005675594123611594g/aaR
1204445277120123613120t/ggK
207634477407123613407g/aaR
1158818778522123614522t/atW
669693278656123614656t/aaW
1202553178902123614902t/ccY
668288878911123614911g/agR
298239081305123617305g/cgS
217939481717123617717a/taW
247337781735123617735c/ttY
217939581840123617840t/ctY
250297882511123618511c/tcY
250297982790123618790a/ccM
669853583323123619323t/atW
250298083464123619464t/ccY
1055424283916-83920123619916{circumflex over ( )}cact/—cactNNNN
23619919
669780585471123621471a/ccM
642411485688123621688c/acM
577305886196123622196—/ttgN
464911486323123622323t/agK
642411586706123622706a/gaR
|
Assay for Verifying and Allelotyping SNPs
The methods used to verify and allelotype the proximal SNPs of Table 37 are the same methods described in Examples 1 and 2 herein. The PCR primers and extend primers used in these assays are provided in Table 38 and Table 39, respectively.
TABLE 38
|
|
dbSNP rs#Forward PCR primerReverse PCR primer
|
|
627451ACGTTGGATGATCTTCTGACCTCGTGATCCACGTTGGATGCAACAGAGTGAGACCCTGTC
|
12082331ACGTTGGATGGGGTTCATGCCGTTCTCCTGACGTTGGATGAAATTAGCCGGGTGTAGTGG
|
2267960ACGTTGGATGCACCTAGCATCATCTAGACCACGTTGGATGTTAGGGTACCAAGTGGATGG
|
7519640ACGTTGGATGGCGTTGGCATTTATAAGGCCACGTTGGATGTCTCCAGGGTCTACTTCAAG
|
12086741ACGTTGGATGAACTTGGAGCGCCGACTCCGACGTTGGATGATGCACGGAGGGCGGAGCT
|
3934189ACGTTGGATGACCAGAGAAGTGAGTGACAGACGTTGGATGTTTTGTTGTTTATTGTAC
|
12135415ACGTTGGATGATCTCGGCTCACTGCAACCTACGTTGGATGGCGCCTACAATACCAGCTAC
|
12088267ACGTTGGATGTAGTAGAGACAGGGTTTCACACGTTGGATGTGACGGAGAATGCCAAACAC
|
12084665ACGTTGGATGTAGTAGAGACAGGGTTTCACACGTTGGATGTGACGGAGAATGCCAAACAC
|
550850ACGTTGGATGTCTCCCTTAAGTGAGCCAAGACGTTGGATGTTCCACACCTGTGTTCATGG
|
557227ACGTTGGATGTGTAACACAGGACGAGGATCACGTTGGATGATGGCACCATTGCACTCCAG
|
12137502ACGTTGGATGAGCCTGGACAACAAGAGCAAACGTTGGATGTGTAACACAGGACGAGGATC
|
12118858ACGTTGGATGAGCCTGGACAACAAGAGCAAACGTTGGATGTGTAACACAGGACGAGGATC
|
2294495ACGTTGGATGGGAATTAGATGGTTATAATGGACGTTGGATGCACCACTTTAACTAAAGTAC
|
12401650ACGTTGGATGAGAAGAGCAATTCCCGAAAGACGTTGGATGTCCAGGTTTCTTGGTAGTCC
|
2235541ACGTTGGATGGGGACTACCAAGAAACCTGGACGTTGGATGTCCACGAGCTCCGAGAGTTTCCTATG
|
520713ACGTTGGATGAGGGAGGCAAACACTTCTTCACGTTGGATGACAATGCAAGGGAGAAACCG
|
550252ACGTTGGATGAGGCAGTGGACGGTAATTGGACGTTGGATGTCCACGCTGCAGGTGCCTGATGTGTT
|
HT014-AAACGTTGGATGTTCTAAACCAACCAGGCGTGACGTTGGATGTTACCTAAGGTGATCTGCCC
|
12093683ACGTTGGATGTAAGCTCCTGTAATCCCAGCACGTTGGATGAGGCTGATCTCGAACTCTTG
|
10917421ACGTTGGATGATATTAGCCAGCTGTGGTGGACGTTGGATGACTGCATCCTTGAACTCCTG
|
2744873ACGTTGGATGACCTAGGAGTGACCAGTTTCACGTTGGATGGGGAGTTATTTTTTTCCTAG
|
12091764ACGTTGGATGTGGGTTCAAGCGATTCTCACACGTTGGATGTAAAATAGCTGGGCGTGGTG
|
HT014-ABACGTTGGATGGAAACCAGAACCAGGACATCACGTTGGATGACAGAGCAAGACTCTGTCTC
|
2076345ACGTTGGATGATGGGAAGCAGCCATGCTTCACGTTGGATGTCCACGTGGTGCTTGGGCCATCATAG
|
2076346ACGTTGGATGGCAGTCCACAAAATGTAATACACGTTGGATGAAGTAACTTGGAGTTCCTGC
|
2473379ACGTTGGATGTAATCCCAGCACTTTGGCAGACGTTGGATGTCTCATTATGTTGTCCAGGC
|
6679300ACGTTGGATGTTTUTGAGATGGAGTCTCGCACGTTGGATGAATGGCATGAACCTGGAAGG
|
11811395ACGTTGGATGAATGACAGGCCCTCTTACTGACGTTGGATGAGAGTGAGACTCTGTCTCCA
|
8179467ACGTTGGATGAATGACAGGCCCTCTTACTGACGTTGGATGAGAGTGAGACTCTGTCTCCA
|
8179468ACGTTGGATGTATATCTAATTGGGTCTTCCACGTTGGATGAGAGTGAGACTCTGTCTCCA
|
10917423ACGTTGGATGTACCAGCGTGAACCACCATGACGTTGGATGCATCCCCTTAGGATACTGGG
|
7536699ACGTTGGATGGCCTCACAAATAGCCAAACCACGTTGGATGTTGCATAGCCACCTTAGACC
|
3215497ACGTTGGATGTCATCCTTTTTGCGAGTCCCACGTTGGATGTCAATCTCCCAAGGTTCTGC
|
1000213ACGTTGGATGGTGATTCACAGAGAACAAGAGACGTTGGATGGC11TTTGTAGCCCTGAAGG
|
1000212ACGTTGGATGTCAGCAGCAAAGTCCTCTTCACGTTGGATGAGGCTGTAATGCTATGTTGG
|
1000211ACGTTGGATGGGAAGAACACAACTGTTGGCACGTTGGATGCCTGCCTTAAACACACTCAG
|
1045017ACGTTGGATGACATCAGGGATGTGACTTGGACGTTGGATGTCCACGCTGCTCTGCAGCCATTTTAG
|
12059520ACGTTGGATGCCACCACGCCCAGCTAATTTACGTTGGATGAAAGCGGGCAGATGGCTTGA
|
2143118ACGTTGGATGCGTGCCCAGCCTAAAAATTCACGTTGGATGTTCTGCTGGGCATCAGTTAC
|
12126804ACGTTGGATGAATTCTGTGTCTGGTGAGGGACGTTGGATGGCTCCTTGTTCTCCACCATG
|
533276ACGTTGGATGGCCTCTGGAACTGTGAGAAGACGTTGGATGGTGTCTCAGTCATTTCAGGC
|
12402174ACGTTGGATGAATCGCTTAGTGTCTCAGTCACGTTGGATGATGTTTGTTGCCTAAGCCAG
|
2864110ACGTTGGATGATTCCAGCCTGGGTGACAGAACGTTGGATGTGACTGAGACACTAAGCGAT
|
11581873ACGTTGGATGGCAGGAGAATCACATGAACCACGTTGGATGGCAGTAGCTTGATCACTCTC
|
12062449ACGTTGGATGCGCCTGGCCTAATATTTTATACGTTGGATGGTGAGAGATTACTTGAGTCC
|
12033190ACGTTGGATGAGCCCGGGTGAAAGAGCAAGACGTTGGATGATTCATCTGCCTTGACCTC
|
10157566ACGTTGGATGGCTAACACGGTGAAACTCCGACGTTGGATGTCCCGAGTAGTTGGGACTAC
|
486746ACGTTGGATGGAGTAGTTGGGACTACAGGCACGTTGGATGTAACACGGTGAAACTCCGTC
|
11802707ACGTTGGATGAGCCTGACCATCATGGTGAAACGTTGGATGAATTCTCCTGCCTCTTCCTC
|
6668550ACGTTGGATGGCCTAGGTGACAGAAGACTCACGTTGGATGAGCCACAGCACCCAGACTTT
|
7410946ACGTTGGATGTGGTGGTGGGCACCTGTGGTACGTTGGATGAAGCTCCATCTCCCGGGTTC
|
7410970ACGTTGGATGAGTGATTCTTCTGCTTCAGCACGTTGGATGGACAGAGTGAGACTCTGTCT
|
6657558ACGTTGGATGCTTGCAGTGAGCTGAGATCGACGTTGGATGGAGCTACCGAGTCTATGTTC
|
2143119ACGTTGGATGATTTCTAGGACTACCCTGGGACGTTGGATGAGAGTGAGACCCTATCTCCA
|
7514394ACGTTGGATGAGTGTGAGCACACAGGTTAGACGTTGGATGCCCCATTCTCTCCATATCTC
|
11591202ACGTTGGATGTAATTCGCATGATCCTGTGGACGTTGGATGTGAGACCATCCCAAACTTTC
|
6673991ACGTTGGATGTCAGGAGATCCTTCCACTTCACGTTGGATGTAGGGAGACCCCATCTTTAC
|
HT014-ACACGTTGGATGGCAATTAAAGAACTCAGCAGGACGTTGGATGATCTTTTGACCTCGTGATCC
|
12034848ACGTTGGATGGTCCTACGTCAGTTCCGCTCACGTTGGATGGCATGCGCGTGGGGAGAAG
|
2502984ACGTTGGATGTGGGAACCACCTTTCATCTCACGTTGGATGTCCACGACCATTGGTGCTAATGGCTG
|
3831910ACGTTGGATGAGGGGAAATATTAAACCCGGACGTTGGATGCTCAAAGGAGCTCCTAATTC
|
11379444ACGTTGGATGAGGGGAAATATTAAACCCGGACGTTGGATGCAAAGGAGCTCCTAATTCTC
|
725119ACGTTGGATGAATTCTCCTGCCTCACCCTCACGTTGGATGTGGCCAACCTGGTAAAACCC
|
10917425ACGTTGGATGGGTCTTGAACTCCTGACCTCACGTTGGATGCGCAGTGGCTTACACCTATA
|
12077788ACGTTGGATGAGGTTCATGCCATTCTCCTGACGTTGGATGTAACACGGTGAAACCCCGTC
|
12077830ACGTTGGATGATTACAGGTGTGAGCCACTGACGTTGGATGGAAGAGGCCTCGATATTAGC
|
2473380ACGTTGGATGCTGTAGTCCCAGCTACTCAGACGTTGGATGTCTCAGCTCACTGCAACCTC
|
2473381ACGTTGGATGAGCTCCAGCTTGTAAAAGCCACGTTGGATGTTGCCTGTCCAAAGGAGAAG
|
11545132ACGTTGGATGGTAACCTGATGGACCCTATGACGTTGGATGACGAGGTGACCATCTGCAAT
|
1046924ACGTTGGATGCCAGCCCTTAGGAAATAAAGACGTTGGATGATTACGAAGCATCTGCCAAC
|
4237ACGTTGGATGGCTGTGGAAATTGGGTCTTGACGTTGGATGTCCACGCACATGGCCACATTAACTGG
|
4375317ACGTTGGATGTGAGTAGCTGGGACTACAGGACGTTGGATGCACGGTGAAACCGTCTCTAC
|
11584220ACGTTGGATGAACTTTACCACCTTCCCATCACGTTGGATGGAATAGGGCATGAAAGCCAG
|
2232975ACGTTGGATGAAGTAGCCTGGCCGACAGTAACGTTGGATGCCAACATGGCAGCTTCTATC
|
2502985ACGTTGGATGAAGTCCCCAAGACTGGACAGACGTTGGATGTCGGGAGGGTCCCGGAGAG
|
3835423ACGTTGGATGAAAGCGTAAGAACTCCACCCACGTTGGATGAGGGCTCGTTTGCAGTCAGT
|
2232976ACGTTGGATGATTCTTTGTGCCCAGGACAGACGTTGGATGAAGAGCAAAACCAGGCACAG
|
2232977ACGTTGGATGTGTCCTGTGCCTGGTTTTGCACGTTGGATGTACCACACATACACCACACG
|
2232978ACGTTGGATGTGTCTGGCCGTGGGTGAAAGACGTTGGATGAACACCATGTCTGTGCCCCT
|
2232979ACGTTGGATGACGTTGGATGAACTCTGCCCACGTTGGATGGAGTATCCTGAGGCCAGCAG
ACCCCTCC
|
2232980ACGTTGGATGGTGGGCAGAAGTTGGAGGACACGTTGGATGGGAAAAGGATGGGAAATGGG
|
2232981ACGTTGGATGAGAAGTTGGAGGACCTAGGGACGTTGGATGTTACCCTGTGTCTCCAAGTC
|
2232982ACGTTGGATGATGTACTTGACGTGAGGGAGACGTTGGATGTTCTCTTCCTACCACATCGG
|
2232983ACGTTGGATGAGGCTTTTCACAGGTGAGGGACGTTGGATGTGGAGGGAGGAGAGAGAGG
|
2232984ACGTTGGATGGTGGCACCATCTTGGATCTGACGTTGGATGGTGGGAAAAGGACAGGTCAG
|
2232985ACGTTGGATGAGAGGCCTGTGGGAAAAGGAACGTTGGATGGTGGCACCATCTTGGATCTG
|
2232986ACGTTGGATGAGGTGGCTAAGGCCAGGAAGACGTTGGATGCCTTCCTGACCTGTCCTTTT
|
2745ACGTTGGATGCACCCAAAAACCACATGGAGACGTTGGATGTCCACGACTTTGTCCCCACTCTAGAG
|
2744ACGTTGGATGTAATTTTATCGGAATCCAGGACGTTGGATGTCCACGCTGTCTCCATGTGGTTTTTG
|
11546127ACGTTGGATGAGGACCCCCAAGAGTGAGTGAACGTTGGATGGGAAAGCTCTTTCAGAGCAA
|
1049988ACGTTGGATGATAAATGAGTGCCTGGGAGGACGTTGGATGTCCAAGAGTTCATCAGGACC
|
1803613ACGTTGGATGTCCACTGACCAGGAGGCCACGTTGGATGTGGACCCTGTGGAAGATA
|
1803612ACGTTGGATGCCAAGGCTCCACTGACCAACGTTGGATGTGTGGAAGATAAGAGTTAG
|
HT014-ADACGTTGGATGAGCCTCTGGCAGGAACTCAGACGTTGGATGTCCACGTCATGCCTGGTGGGCTAAGC
|
3209973ACGTTGGATGAGCACACACCTCGCCGTGTTACGTTGGATGTTGCGTGCCAAAGCCTGAAG
|
3180545ACGTTGGATGACATCCTGTCCAGCCCTAAGACGTTGGATGTGATGTGGCAGCCTGTTACG
|
3180383ACGTTGGATGTGTCCAGCCCTAAGGCTGCTACGTTGGATGGTGATGTGGCAGCCTGTTAC
|
3177814ACGTTGGATGGTGATGTGGCAGCCTGTTACACGTTGGATGTGTCCAGCCCTAAGGCTGCT
|
3180546ACGTTGGATGGCTAAGCTCCAACTACCTCCACGTTGGATGTAACAGGCTGCCACATCACC
|
3180547ACGTTGGATGGCTAAGCTCCAACTACCTCCACGTTGGATGTAACAGGCTGCCACATCACC
|
11805398ACGTTGGATGGGGATCTGCAAGACAGGAGGACGTTGGATGACTTCTGCTTCTTAAAGAC
|
760941ACGTTGGATGAGAAGGCCTCTGGGAAGAAGACGTTGGATGTCCACGAAAGCTGCTCTGTTGCTGAG
|
3177813ACGTTGGATGAGTGCTGCAGATGGTCCAGGACGTTGGATGAGGTGGGTGAGGTGGGTGG
|
3180548ACGTTGGATGACGTTGGATGAGGTGGGTGAGACGTTGGATGATTCAGTGCTGCAGATGGTC
GTGGGTGG
|
3179864ACGTTGGATGGGCCTACCTTCTTCCCAGAGACGTTGGATGGCTATTCAGTGCTGCAGATG
|
3177812ACGTTGGATGACGGGCACAGGCTATTCAGTACGTTGGATGTTCTTCCCAGAGGCCTTCTC
|
3179863ACGTTGGATGGCTCCATAAACCCTGTTCTCACGTTGGATGCCATCTGCAGCACTGAATAG
|
6692104ACGTTGGATGTATGACACAGAGGATGGCACACGTTGGATGTGTTCCCCCTGACTCTCCTT
|
3180549ACGTTGGATGCCTGAATGTCTTTGGCAATGACGTTGGATGTTCCTGGCTCCCACTCCTAG
|
3179862ACGTTGGATGTGGTCCTAGGCTCACCTGTGACGTTGGATGGGAGGCCCTGAATGTCTTTG
|
3177811ACGTTGGATGTCTCCACCTCCAGGTGGCGATACGTTGGATGCTCACCTGTGCCATCCTCTG
|
3177810ACGTTGGATGCCATCCTCTGTGTCATAGTCACGTTGGATGAACTGACCTGATCTCCACCT
|
3180382ACGTTGGATGATCTGGGACGAACTGACCTGACGTTGGATGTTGCCAAAGACATTCAGGGC
|
11546126ACGTTGGATGAAGAACCTGGTGTTCAGCAGACGTTGGATGTAAGGGTTGGTACAACCACC
|
7551384ACGTTGGATGATGTAGGCCACATCATCACGACGTTGGATGAAAACCCTGGGTTCCACCTC
|
12141511ACGTTGGATGAGTTTACACCTAGCGAAGGCACGTTGGATGAAAATGGCAGCACGATTGGG
|
2473382ACGTTGGATGCAGTTTACACCTAGCGAAGGACGTTGGATGAAAATGGCAGCACGATTGGG
|
12038166ACGTTGGATGTCAGCCTCTGCCCATGCCAACGTTGGATGAGTAGCCTAAGTTGGGCGGG
|
6666908ACGTTGGATGCGGGCCCTTTAAGTGCTGACACGTTGGATGAACCCGAGTGACATGTTTCC
|
12041159ACGTTGGATGTTGCAAACTGGACTTCCAGCACGTTGGATGGGTGTGTGCCAAACCATGAA
|
12031592ACGTTGGATGTTCATCACGCAGGATGTCACACGTTGGATGCGACGGCAGGTTAGAAAATG
|
1062598ACGTTGGATGTGTGGAAAGTGGAGAGCTACACGTTGGATGAAATCACATTCAGCGTGGAG
|
11714AGCGGATAACAATTTCACACAGGCAGAGGCACGTTGGATGAGCGTGGAGATTTTCCAGAG
CATTTGTGGAAAG
|
3203593ACGTTGGATGTCATGGAGGTTCTTCCCAAGACGTTGGATGTTCCAGAGATGCTGGAGTTG
|
1042436ACGTTGGATGAGAAGTCAGAGAGCAAGGGACGTTGGATGTGGATGGAATCCGCGAGCTG
|
2076343ACGTTGGATGTCATGGTATGCCCTCAACACACGTTGGATGGCTGTCAAGGAAAAAGCCTG
|
12131539ACGTTGGATGAGACAGACAGGAGCTCACAGACGTTGGATGAGCATGGACAGACAACTGTG
|
11583935ACGTTGGATGGGCCCACAGAGGTAAAAAACACGTTGGATGTTTCTGTCTGGCCCTTTCAG
|
12140263ACGTTGGATGACACGCATGGGCATAAGAAGACGTTGGATGTTCCATGTTCCTGGTGTCTC
|
3835225ACGTTGGATGTCAGAAAAGGTCTCCCTGAGACGTTGGATGTCTGCCAGCAGTATCTTTCC
|
2473374ACGTTGGATGTCCCTCATGCTGCCTGAGATACGTTGGATGTCCTGAAGCAGGTGGGAATG
|
2256179ACGTTGGATGTGTCTCGAGCTTCACAGATCACGTTGGATGTCCACGAATCCAGGTGAGAGACATGG
|
974698ACGTTGGATGAGGAGCCTCTCAAACGGAACACGTTGGATGTTTCAGACTGAGCTGGGAAG
|
1018396ACGTTGGATGAGGTGAGTCTGAGGCAAAACACGTTGGATGTCCACGCTGCCATGAAACAGAGAAGC
|
719399ACGTTGGATGTAACTCCCTTGACTGTCTCCACGTTGGATGAATGGTGGACACAGTCATGG
|
719400ACGTTGGATGTAGGTGTCATGGCAGTGGACACGTTGGATGTCCACGCACCCCAGGGATCATGAAAG
|
2502986ACGTTGGATGGGATTGCTTGAGTCTGAGAGACGTTGGATGTCACTCTGTCATTCGGCTAG
|
6679378ACGTTGGATGAGATGTGCAAATGGGCTTCCACGTTGGATGTTGTGATCTGCCCATCTCAG
|
2473375ACGTTGGATGGCAACTTCACTTTTCTGAGCACGTTGGATGTAGCCTCAGTTGCCACAATC
|
2473376ACGTTGGATGGGTACGGCTACAGAAAAGAGACGTTGGATGGTGACTAATCAAGTGCAGAC
|
12136455ACGTTGGATGAATCACTTGAACCCAGGAGGACGTTGGATGTTTGAGACAGAGTCTCACTC
|
2502987ACGTTGGATGAAGTGATTCTCCTGCCTCAGACGTTGGATGTAGTGGATAGAAACCCCGTC
|
11551767ACGTTGGATGGGAAGTAGTCATCTTTGGAGACGTTGGATGCTGAAAACTCTCCTCTATGG
|
11591205ACGTTGGATGACATGGTGAAACGCTGTCTCACGTTGGATGTGAGTAGCTGGGATTACAGG
|
12083298ACGTTGGATGTCTCCTGACCTCATGATCTGACGTTGGATGAATCCCATACGACTGGTGAC
|
12138604ACGTTGGATGGGTTCAAGTGATTCTCCCACACGTTGGATGCAAAAAATTAGCCGGTCGTG
|
12136042ACGTTGGATGAAAAAATTAGCCGGTCGTGGACGTTGGATGACCTCCCAGGTTCAAGTGAT
|
12138606ACGTTGGATGCACCTCCCAGGTTCAAGTGAACGTTGGATGAAAATTAGCCGGTCGTGGTG
|
12136045ACGTTGGATGAGGCTGAGGTGGGAGAATCAACGTTGGATGGTACAGTGGCATGATCTCGG
|
12116596ACGTTGGATGTGAGGTGGGAGAATCACTTGACGTTGGATGTGGAGTACAGTGGCATGATC
|
12138610ACGTTGGATGAATCACTTGAACCTGGGAGGACGTTGGATGTTAGACAGAGTCTTGCTCTG
|
12136069ACGTTGGATGAGACAGAGTCTTGCTCTGTCACGTTGGATGAATCACTTGAACCTGGGAGG
|
12116617ACGTTGGATGATCATGCCACTGTACTCCAGACGTTGGATGCTGTGTCTCTGTGTCTTCAC
|
7540056ACGTTGGATGTGGCTAACACGATGAAACCCACGTTGGATGCCGGGTTCAAGTGATTCTCC
|
12044452ACGTTGGATGCTATCTTTGTGAAGCAGGAGACGTTGGATGTCTAAAACCCTCTATGCCTG
|
2076344ACGTTGGATGGCCCTAGCCCTCAATGAAAGACGTTGGATGCTTCTACTTGCTTCAAAGGC
|
11588187ACGTTGGATGTTCTCCAGTTTCTCTCCCACACGTTGGATGCAATACAGTGAGACTCCATC
|
6696932ACGTTGGATGTTCCGGGTTCAAGCGATTCTACGTTGGATGTGGTGAAACCCCATCTCTAC
|
12025531ACGTTGGATGAGTGAGTGCTTGTTGGAAACACGTTGGATGATAGCAGTAAGCAGAAGCAG
|
6682888ACGTTGGATGAGTGAGTGCTTGTTGGAAACACGTTGGATGGCAGTAAGCAGAAGCAGAAC
|
2982390ACGTTGGATGCCGTGCCTGGCCTTTTTTTAACGTTGGATGAAGATCGTGCCACTGTACTC
|
2179394ACGTTGGATGTAGCAACCTGTTGGGTGGAGACGTTGGATGTGAGTTGCCTCCTCTGACCT
|
2473377ACGTTGGATGTCTGACCTCCTGGAATCATCACGTTGGATGAAGGCAGGGAGCTTAGCAAC
|
2179395ACGTTGGATGTTTGCAAAGGGTGGTCAGAGACGTTGGATGGGGTTCCTCATCTGGCTTTT
|
2502978ACGTTGGATGACACTGTGTGATCCGCTAAGACGTTGGATGGTACATGTTCCAGCTGCTTC
|
2502979ACGTTGGATGACTGTUATTTATCGAGCCCCACGTTGGATGTTCATGAGACAGGGACTTTG
|
6698535ACGTTGGATGATTTGCCAGGCACATACAAGACGTTGGATGAGACAGAATGAGACTGTATC
|
2502980ACGTTGGATGACCTGGTGAAATCCTGTCTCACGTTGGATGCCAGGTTCAAGTGATTCTCC
|
10554242ACGTTGGATGAGTAATCTTCCCGAGGTGACACGTTGGATGTTGTGCTCTAGAGCCACACT
|
6697805ACGTTGGATGATCAAAACGGAGAGAGGCTGACGTTGGATGTGACCGATGGCTCGTCTGGTG
|
6424114ACGTTGGATGTGGCTAACATGGCGAAACCCACGTTGGATGCACCACGCCCGGCTTTTTTT
|
5773058ACGTTGGATGATGCTACACCGTCTGGAAAGACGTTGGATGTTATCTAGGTGTACTTTCTG
|
4649114ACGTTGGATGGCCCTGAGGCAAAGAAAATGACGTTGGATGAGTGAGACTCCATCTCAAAC
|
6424115ACGTTGGATGACCCCACTAATTGGTCACAGACGTTGGATGCAACACAGTGAGACTTCGTC
|
TABLE 39
|
|
|
dbSNP rs#
Extend Primer
Term Mix
|
|
|
627451
GGATTACAGGCATGAGCCAC
ACG
|
|
12082331
CCGTTCTCCTGCCTCAGC
ACT
|
|
2267960
GACCTTATAATCAGCATTGGAT
ACT
|
|
7519640
GGCCAGGGTCTGGCGCG
ACT
|
|
12086741
CGGCCTCCTCGCCGGAA
ACG
|
|
3934189
AAGAACGCGTTTAACTTAAT
ACT
|
|
12135415
GTCTCCCGGGTTCAGGCA
ACT
|
|
12088267
CCAGGCTGGTCTTGAACTCA
ACT
|
|
12084665
CAGGCTGGTCTTGAACTCAG
ACG
|
|
550850
AACAGAGTTACAGCAATGTCTA
ACT
|
|
557227
GGAGATGGAGTTITGCT
CGT
|
|
12137502
GGACAACAAGAGCAAAACTCC
CGT
|
|
12118858
GACAACAAGAGCAAAACTCCAT
ACG
|
|
2294495
GAATGTTCTGGAAACCA
ACG
|
|
12401650
AGCGCCCTCGGGATGCC
ACG
|
|
2235541
AAGAAACCTGGAAAGCCA
ACG
|
|
520713
CTGTCCTTCTCTTTCTTTA
ACG
|
|
550252
GACGGTAATTGGCCTGTATC
ACT
|
|
HT014-AA
CTGTAATCCCAGCACTTTGG
ACT
|
|
12093683
CACTTTAGGAGGCCAAGGCA
ACT
|
|
10917421
CCCAGCTACTTGGGAGGAT
ACG
|
|
2744873
TTGGTCTTCATCTTAGTAGT
CGT
|
|
12091764
ATTCTCACGCCTCAGCCTC
ACG
|
|
HT014-AB
TTGTGTACAAGCACTTTTCCAT
CGT
|
|
2076345
CCATGCTTCCGCCAGTAG
ACG
|
|
2076346
GAGTTAAAAACTAGTGCTGA
ACT
|
|
2473379
TCCCTTGAATCCAGGAGTTC
ACT
|
|
6679300
CCAGGCTGGAGTGCAGTG
ACT
|
|
11811395
GCCCTCTTACTGTTTTTTTATAG
CGT
|
|
8179467
CTAATTGGGTCTTCCAATTTATTT
CGT
|
|
8179468
GGGTCTTCCAATTTATTTATTT
CGT
|
|
10917423
GAACCACCATGCCTGGCC
ACT
|
|
7536699
CAAACCAGTAAACAGCA
ACT
|
|
3215497
CCCACCTTTTTGTTTTTTTTTTTT
ACG
|
|
1000213
CAAGAGATTAAAGTGCTGG
CGT
|
|
1000212
AAGTCCTCTTCCCAAGCCAA
ACG
|
|
1000211
TTGGGAAGAGGACTTTGCTG
ACG
|
|
1045017
TGTGACTTGGTGCGAAGA
ACT
|
|
12059520
CGTTGGCCAGGCTGGTCT
ACT
|
|
2143118
CTCAAGTTCAACAGTCATTT
ACG
|
|
12126804
GGCCCTCTTCTTGGTTTGCA
ACT
|
|
533276
TGCCTAAGCCAGTCAGT
ACG
|
|
12402174
TAGTGTCTCAGTCATTTCAGG
ACT
|
|
2864110
TGACAGAGTGAGACTTC
CGT
|
|
11581873
CACATGAACCCGGGAGGCA
ACT
|
|
12062449
ATCTCACTATGTTGCCCAGG
ACG
|
|
12033190
GTGAAAGAGCAAGACCCTGT
ACG
|
|
10157566
AGCCGAGCGTGGTGGCG
ACT
|
|
486746
CTCGCCACCACGCTCGG
ACT
|
|
11802707
GGTGTGAGCCTGTAATTCCA
ACT
|
|
6668550
GTGACAGAAGACTCCATCTC
CGT
|
|
7410946
CGGGAGGCTGAGGCAGGA
ACT
|
|
7410970
CGCACACCACCATACCCAG
ACT
|
|
6657558
CTGCACTCCAGCCTGGG
ACT
|
|
2143119
ACTACCCTGGGGCAGGTAA
ACT
|
|
7514394
CTGCATGCGTGGACACAAG
ACT
|
|
11591202
GCATGATCCTGTGGATTAGC
ACT
|
|
6673991
GAGCCACCATGCTGGGCTA
ACT
|
|
HT014-AC
GAACTCAGCAGGCCGGGC
ACT
|
|
12034848
TCCGCTCGACCCCACCC
ACG
|
|
2502984
CTTTCATCTCCCTAGGCTC
ACT
|
|
3831910
ACCCGGTAAGAAGAAAA
CGT
|
|
11379444
TATTAAACCCGGTAAGAAGAAAA
CGT
|
|
725119
CCAGGCCCAGCTAATTTTTGT
CGT
|
|
10917425
CTCCTGACCTCAGGTAATCC
ACT
|
|
12077788
CCTGCCACCACGCCCGG
ACT
|
|
12077830
TGAGCCACTGCGCCCGG
ACT
|
|
2473380
GCATGAGAGTCACTTGAACC
ACG
|
|
2473381
GTAAAAGCCAGGCAAAG
ACT
|
|
11545132
TCTGCTGGGTTGGCAGATG
CGT
|
|
1046924
GGGTAACCTGATGGACCCT
ACT
|
|
4237
GGCATCTGGCAGTCATGG
ACT
|
|
4375317
GCTCCCGCCACCGCACC
ACG
|
|
11584220
ACCTCTTAAGGCCTCGGGT
ACT
|
|
2232975
GCCGACAGTACGGAACC
CGT
|
|
2502985
TCACTCCCCACCCCCAT
ACG
|
|
3835423
GGTGCTCCACGCCCCCC
ACG
|
|
2232976
GTGCTGTGTGGGGCTGA
ACT
|
|
2232977
CTGGTTTTGCTCTTGAC
ACG
|
|
2232978
TGAAAGGGGACCCTTAC
ACG
|
|
2232979
AGGTAGCAGCCAAACAG
ACT
|
|
2232980
AGTTGGAGGACCTAGGG
ACT
|
|
2232981
AGGGGAAGCCTTCCTGT
ACG
|
|
2232982
GTGCCTGTAGGAGGGAC
ACT
|
|
2232983
GGTGAGTGAGCTGTGCC
CGT
|
|
2232984
GGTCGAGCCCCTGTCCC
ACG
|
|
2232985
AAAGGACAGGTCAGGAA
ACT
|
|
2232986
GGCCAGGAAGGAAGGCCC
ACT
|
|
2745
CACATGGAGACAGAAGAC
ACT
|
|
2744
TATCGGAATCCAGGACACAA
ACT
|
|
11546127
GGCTCTGGCACAAAACCTC
CGT
|
|
1049988
GAGGAGGAGGTTTTGTGCCA
ACT
|
|
1803613
ACCAGGAGGCCGAGGTCT
ACG
|
|
1803612
TCCACTGACCAGGAGGCC
ACT
|
|
HT014-AD
TGGAGCTGCTGGGGCCAA
ACT
|
|
3209973
CCTCGCCGTGTTGCAGGT
ACT
|
|
3180545
CTAAGGCTGCTGTCCACCC
CGT
|
|
3180383
CCAGCTCCTCTTGGGCCA
ACT
|
|
3177814
CAGCCTGTTACGCCAACCC
CGT
|
|
3180546
CCCGTACAAGGTGGTGGC
CGT
|
|
3180547
CAGATCCCGTACAAGGTGGT
ACT
|
|
11805398
CAGGAGGTAGTTGGAGCTTA
ACT
|
|
760941
AAGAAGGTAGGCCCCCCC
ACT
|
|
3177813
CTATGGAGAAGGCCTCTGG
ACT
|
|
3180548
CCTACCTTCTTCCCAGA
ACT
|
|
3179864
CAGAGGCCTTCTCCATA
ACT
|
|
3177812
ACAGGCTATTCAGTGCTGCA
ACT
|
|
3179863
GTGGGCCAGATCTACAA
CGT
|
|
6692104
ACAGGTGAGCCTAGGAC
ACT
|
|
3180549
ACTATGACACAGAGGATG
ACT
|
|
3179862
CCTGTGCCATCCTCTGTGT
CGT
|
|
3177811
GGAGGCCCTGAATGTCTTTG
ACT
|
|
3177810
CCAAAGACATTCAGGGCCTC
CGT
|
|
3180382
CTGATCTCCACCTCCAG
ACT
|
|
11546126
GTGTACGGGAACCCCCAG
ACG
|
|
7551384
CCAGACACACATTCCCC
ACT
|
|
12141511
AGACAGAACCCCTTCCTGC
ACT
|
|
2473382
CTGAGCAGACAGAACCC
ACG
|
|
12038166
CCGGTCACTCCTGGCTCA
ACT
|
|
6666908
GTGCTGACGGCCCACTC
CGT
|
|
12041159
CCTTAGTCCCGTGGGATCG
ACT
|
|
12031592
CTAGCTCTACTACTTTTCATTG
ACT
|
|
1062598
ATCTGCCAACTCCAGCATCT
ACG
|
|
11714
GATGCTGGAGTTGGCAGA
ACG
|
|
3203593
GGCCATTTGTGGAAAGTGGA
ACT
|
|
1042436
GCAGGGTGGAGCCGTGTA
ACT
|
|
2076343
CAGGGAAAACATCAGCATGG
ACT
|
|
12131539
CACAGGCAGCTGGTGCCC
ACG
|
|
11583935
GACAATTGTGAGGCAGAGAG
ACT
|
|
12140263
CAGGGTGACTTTGACAGTTCA
ACT
|
|
3835225
GGTGGCTTTCAGACTGGAAC
ACG
|
|
2473374
CTGCCTGAGATGGACCC
ACG
|
|
2256179
CTTCACAGATCAGAACAC
ACT
|
|
974698
CAGATCATCTCCCTCCC
ACG
|
|
1018396
GGCAAAACTTCATCCTGATCA
ACG
|
|
719399
GTCTCCCCAACACAGAG
ACG
|
|
719400
ACTTCCTGCATGACAGCAGA
ACG
|
|
2502986
AGTAAGCCGAGATCACA
CGT
|
|
6679378
CGGGCACGGTGGCTCAC
ACT
|
|
2473375
GATGACCCTTTGGTCATA
ACG
|
|
2473376
CGGGACCAAATCATGCA
ACT
|
|
12136455
GTGAGCCAAGATCACGCCA
ACT
|
|
2502987
GCCTCAGCCTCCCAAGTAG
CGT
|
|
11551767
GAGCTGCCTCAGAGCTCTT
ACG
|
|
11591205
AAATTAGCCGGGCGTGGTG
ACT
|
|
12083298
CGGCCTCCCAAAGTGCTG
CGT
|
|
12138604
TCTCCCACCTCAGCCTCC
ACG
|
|
12136042
CTACTCGGGAGGCTGAGG
ACG
|
|
12138606
CCAGGTTCAAGTGATTCTCC
ACG
|
|
12136045
GTGGGAGAATCACTTGAACC
ACG
|
|
12116596
TTGAACCTGGGAGGTGGAG
ACT
|
|
12138610
GTGGAGCTTGCAGTGAGCC
ACT
|
|
12136069
TGTCGCCCAGGCTGGAGT
ACT
|
|
12116617
CACTGTACTCCAGCCTGGG
ACG
|
|
7540056
GTGGCAGGTACCTGTAATCC
ACG
|
|
12044452
TTTGTGAAGCAGGAGTTGTCA
ACT
|
|
2076344
CAATGAAAGGCCTTTCTC
ACG
|
|
11588187
CTCTAACTTAATCTTTCCACAAAA
CGT
|
|
6696932
CCTCCAGAGTAGATGGGATT
CGT
|
|
12025531
GTGTAAGTTCCCGAAGGGCA
ACT
|
|
6682888
AACAATAGTGTGTAAGTTCC
ACG
|
|
2982390
GGAAATGGAGTCTTCCT
ACT
|
|
2179394
GTAGGGGCGAGTGATGA
CGT
|
|
2473377
TCATCACTCGCCCCTAC
ACG
|
|
2179395
GAAAGATGAGAGAGAGATGT
ACT
|
|
2502978
CGCTAAGGATCTCAACC
ACG
|
|
2502979
GCCCCTATTATGTCCCAGG
ACT
|
|
6698535
AAGAGCCATTTACATATTTATTTAT
CGT
|
|
2502980
AGCCAGGTGTGGTGGTGC
ACT
|
|
10554242
AGGTGACATGGGGAGTTACT
ACT
|
|
6697805
CCAGCTTCGGAAGTCAC
ACT
|
|
6424114
GCGAAACCCCCGTCTCT
CGT
|
|
5773058
CCTGGATAGATTTTTTTTTTTTT
ACG
|
|
4649114
TTCTCTCTTTTGTTTTGTTG
ACT
|
|
6424115
GGGTACAAACTTTATTTAAAACAA
ACT
|
|
Genetic Analysis of Allelotyping Results
Allelotyping results are shown for cases and controls in Table 40. The allele frequency for the A2 allele is noted in the fifth and sixth columns for breast cancer pools and control pools, respectively, where “AF” is allele frequency. SNPs with blank allele frequencies were untyped.
TABLE 40
|
|
Position inBreast Cancer
SEQ IDChromosomeA1/A2Associated
dbSNP rs#NO: 5PositionAlleleCase AFControl AFp-ValueORAllele
|
|
62745121523536215G/AG = 0.753G = 0.7650.6811.06A
A = 0.247A = 0.235
1208233138523536385G/CG = 0.999G = 1.0000.9132.58C
C = 0.001 C = 0.000
2267960201923538019T/CT = 0.734 T = 0.742 0.7961.04C
C = 0.266 C = 0.258
7519640311223539112C/GC = 0.77 C = 0.778 0.821.04G
G = 0.230G = 0.222
12086741343723539437G/AG = 0.999G = 0.9990.9791.15A
A = 0.001A = 0.001
3934189432623540326T/CT = 1.000 T = 1.000 0.9480.43T
C = 0.000 C = 0.000
12135415452323540523A/GA =A = 0.997
G =G = 0.003
12088267464523540645A/GA = 0.001A = 0 0.9630.00A
G = 0.999G = 1.000
12084665464623540646C/TC = 0.875C =
T = 0.125T =
550850583023541830T/CT = 0.906 T = 0.917 0.6241.15C
C = 0.094 C = 0.083
557227655623542556G/TG = 0.999G = 0.9980.9470.51G
T = 0.001 T = 0.002
12137502656823542568T/AT = 0.001 T = 0.001 0.9891.33A
A = 0.999A = 0.999
12118858657023542570C/TC = 1.000 C = 1.000 0.9931.10T
T = 0.000 T = 0.000
2294495935123545351C/TC = 0.781 C = 0.723 0.03420.73C
T = 0.219 T = 0.277
124016501087423546874C/TC = 0.999 C = 0.999 0.9911.08T
T = 0.001 T = 0.001
22355411092623546926C/TC = 0.929 C = 0.936 0.7121.11T
T = 0.071 T = 0.064
5207131146223547462G/AG = 0.997G = 0.9960.960.77G
A = 0.003A = 0.004
5502521241523548415T/CT = 0.002 T = 0.001 0.9690.75T
C = 0.998 C = 0.999
HT014-AA1266823548668A/GA = 0.116A = 0.0760.08220.62A
G = 0.884G = 0.924
120936831388623549886G/CG =G = 0.991
C = C = 0.009
109174211500523551005G/AG = 1.000G = 0.9990.890.12G
A = 0.000A = 0.001
27448731538723551387A/TA = 0.002A = 0.0010.8990.12A
T = 0.998 T = 0.999
120917641563923551639G/AG =G = 0.95
A =A = 0.050
HT014-AB1576123551761A/TA = 0.344A = 0.4250.01651.41T
T = 0.656 T = 0.575
20763451696923552969C/TC = 0.672 C = 0.616 0.07380.78C
T = 0.328 T = 0.384
20763461712423553124T/CT = 0.799 T = 0.822 0.4251.16C
C = 0.201 C = 0.178
24733791736923553369A/GA = 0.994A = 0.9940.9820.95A
G = 0.006G = 0.006
66793001752323553523C/GC = 0.003 C = 0.005 0.8541.93G
G = 0.997G = 0.995
118113951815823554158T/AT = 1.000 T = 1.000 0.9941.07A
A = 0.000A = 0.000
81794671822023554220T/AT = 0.831 T = 0.734 0.003760.56T
A = 0.169A = 0.266
81794681822423554224T/AT = T = 0.099
A =A = 0.901
109174231853823554538A/GA = 0.793A = 0.8310.1421.28G
G = 0.207G = 0.169
75366991881023554810G/CG = 1.000G = 0.9980.8840.45G
C = 0.000 C = 0.002
32154972028223556282—/T— = 0.549— = 0.528 0.5140.92—
T = 0.451 T = 0.472
10002132049523556495C/AC = 0 C = 0.001 0.908A
A = 1.000A = 0.999
10002122063323556633C/TC = 1.000 C = 0.999 0.8430.14C
T = 0.000 T = 0.001
10002112065923556659G/AG = 0.999G = 0.9980.8960.54G
A = 0.001A = 0.002
10450172160323557603A/GA = 0.368A = 0.3420.4450.90A
G = 0.632G = 0.658
120595202407523560075C/GC = 0.995 C = 0.992 0.810.60C
G = 0.005G = 0.008
21431182419123560191C/TC = 0.999 C = 0.999 0.9221.73T
T = 0.001 T = 0.001
121268042501023561010T/CT = 0.002 T = 0.005 0.73.45C
C = 0.998 C = 0.995
5332762512423561124C/TC = 0.999 C = 0.999 0.9710.83C
T = 0.001 T = 0.001
124021742514523561145G/CG = 1.000G = 1.0000.9420.00G
C = 0 C = 0.000
28641102522223561222C/AC = 0.001 C = 0.001 0.9951.05A
A = 0.999A = 0.999
115818732528823561288T/CT = 0.001 T = 0.001 0.9910.40T
C = 0.999 C = 0.999
120624492608023562080G/AG = 0.999G = 0.9990.9510.73G
A = 0.001A = 0.001
120331902655623562556C/TC = 0.998 C = 0.999 0.9251.38T
T = 0.002 T = 0.001
101575662741623563416T/CT = T = 0.006
C = C = 0.994
4867462743223563432C/GC = 1.000 C = 0.998 0.840.36C
G = 0.000G = 0.002
118027072984123565841A/GA = 0.004A = 0.0040.9761.22G
G = 0.996G = 0.996
66685502995523565955C/AC = 0.001 C = 0.002 0.9192.07A
A = 0.999A = 0.998
74109463016023566160A/GA = 0.015A = 0.02 0.7731.32G
G = 0.985G = 0.980
74109703029423566294G/CG = 0.993G = 0.9970.8142.03C
C = 0.007 C = 0.003
66575583103923567039C/GC = 0.019 C = 0.038 0.2272.14G
G = 0.981G = 0.962
21431193207123568071T/CT = 0.001 T = 0.002 0.8879.57C
C = 0.999 C = 0.998
75143943369823569698T/CT = 0.624 T = 0.586 0.230.85T
C = 0.376 C = 0.414
115912023555523571555A/CA = 0.744A = 0.67 0.01420.70A
C = 0.256 C = 0.330
66739913665823572658A/GA = 1.000A = 0.9990.9120.04A
G = 0.000G = 0.001
HT014-AC3772023573720G/CG = 0.069 G = 0.06300.7360.90G
C = 0.931 C = 0.937
120348483830423574304C/TC = 0.623 C = 0.799 5.36E−082.40T
T = 0.377 T = 0.201
25029843900823575008T/CT = 0.197T = 0.16 0.1450.77T
C = 0.803 C = 0.840
38319103998523575985A/—A = 0.152A = 0.01 2.26E−080.05A
— = 0.848— = 0.990
113794443998923575989—/T— = 0.144— = 0.146 0.9571.01T
T = 0.856 T = 0.854
7251194068323576683T/AT = 0 T = 0.002 0.892A
A = 1.000A = 0.998
109174254215823578158T/CT = 0.865 T = 0.856 0.6910.93T
C = 0.135 C = 0.144
120777884436923580369C/GC = 1.000 C = 1.000 0.9860.79C
G = 0.000G = 0.000
120778304450323580503C/GC = 0.999 C = 1.000 0.951.83G
G = 0.001G = 0.000
24733804538223581382C/TC = 0.708 C = 0.709 0.971.01T
T = 0.292 T = 0.291
24733814617123582171A/CA = 1.000A = 1.0000.9430.32A
C = 0.000 C = 0.000
115451324727623583276G/TG = 0.999G = 0.9990.991.06T
T = 0.001 T = 0.001
10469244729923583299T/CT = 1.000 T = 1.000 0.9760.00T
C = 0 C = 0.000
42374760423583604A/GA = 0.664A = 0.6120.08970.80A
G = 0.336G = 0.388
43753174846223584462G/AG = 0.808G = 0.8 0.7990.95G
A = 0.192A = 0.200
115842205078623586786A/CA = 0.001A = 0 0.930.00A
C = 0.999 C = 1.000
22329755105723587057G/TG = 1.000G = 1.0000.9290.32G
T = 0.000 T = 0.000
25029855131023587310G/AG = 0G = 0.0010.958A
A = 1.000A = 0.999
38354235199623587996C/—C = 0.112C = 0.1 0.5550.88C
— = 0.888— = 0.900
22329765254623588546T/GT = 0.998 T = 0.998 0.9841.08G
G = 0.002G = 0.002
22329775260223588602C/TC = 1.000 C = 0.999 0.8970.27C
T = 0.000 T = 0.001
22329785272523588725G/AG = 1.000G = 0.9990.8750.09G
A = 0.000A = 0.001
22329795285823588858A/CA = 0.002A = 0.0020.9820.86A
C = 0.998 C = 0.998
22329805293523588935T/GT = 0.001 T = 0.001 0.9771.70G
G = 0.999G = 0.999
22329815294823588948C/TC = 0.999 C = 1.000 0.9731.28T
T = 0.001 T = 0.000
22329825310223589102T/CT = 0.176 T = 0.075 0.0000070.38T
C = 0.824 C = 0.925
22329835416023590160C/AC = 0.999 C = 0.999 0.9371.48A
A = 0.001A = 0.001
22329845479423590794C/TC = 0.999 C = 0.999 0.9770.86C
T = 0.001 T = 0.001
22329855479823590798T/CT = 0.001 T = 0.005 0.7564.62C
C = 0.999 C = 0.995
22329865485323590853T/CT = 0.789 T = 0.831 0.1521.31C
C = 0.211 C = 0.169
27455542223591422A/GA = 0.815A = 0.8330.4721.13G
G = 0.185G = 0.167
27445546023591460C/GC = 0.964C = 0.95 0.4150.70C
G = 0.036G = 0.050
115461275564523591645G/TG = 0.999G = 0.9990.9961.03T
T = 0.001 T = 0.001
10499885566023591660T/CT = 0.003 T = 0.005 0.8721.45C
C = 0.997 C = 0.995
18036135572923591729C/TC = 1.000 C = 1.000 0.9831.25T
T = 0.000 T = 0.000
18036125573623591736T/GT = 0.026 T = 0.039 0.5391.51G
G = 0.974G = 0.961
HT014-AD5582123591821T/CT = 0.003 T = 0.005 0.8771.44C
C = 0.997 C = 0.995
32099735597023591970T/GT = 0.001 T = 0.001 0.9612.36G
G = 0.999G = 0.999
31805455615023592150C/AC = 0.999 C = 0.999 0.9670.78C
A = 0.001A = 0.001
31803835616723592167A/GA = 0.004A = 0.0050.9321.31G
G = 0.996G = 0.995
31778145617123592171G/TG = 0.999G = 1.0000.9321.86T
T = 0.001 T = 0.000
31805465621023592210G/TG = 0.002G = 0.0010.9570.61G
T = 0.998 T = 0.999
31805475621323592213A/CA = 0.001A = 0.0020.9841.22C
C = 0.999 C = 0.998
118053985625923592259T/GT = 0.001 T = 0.001 0.9970.95T
G = 0.999G = 0.999
7609415646123592461T/CT = 0.672 T = 0.626 0.1480.82T
C = 0.328 C = 0.374
31778135648023592480T/CT = 0.002 T = 0.001 0.9470.50T
C = 0.998 C = 0.999
31805485648623592486A/GA = 0.001A = 0.0020.8998.26G
G = 0.999G = 0.998
31798645649923592499A/GA = 0.002A = 0.0010.8480.16A
G = 0.998G = 0.999
31778125651023592510T/CT = 0.003 T = 0.002 0.9250.57T
C = 0.997 C = 0.998
31798635654323592543G/TG = 1.000G = 1.0000.9940.64G
T = 0.000 T = 0.000
66921045682723592827G/CG = 1.000G = 1.0000.9850.68G
C = 0.000 C = 0.000
31805495684623592846G/CG = 0.001G = 0.0010.9090.13G
C = 0.999 C = 0.999
31798625685923592859C/AC = 0.999 C = 0.997 0.8060.37C
A = 0.001A = 0.003
31778115687023592870G/CG = 0.002G = 0.0020.9960.95G
C = 0.998 C = 0.998
31778105689023592890C/AC = 1.000 C = 1.000 1
A = 0A = 0
31803825690723592907A/CA = 0.002A = 0.0010.8770.25A
C = 0.998 C = 0.999
115461265776723593767C/TC = 0.001 C = 0.002 0.9032.73T
T = 0.999 T = 0.998
75513845877423594774C/GC = 0.002 C = 0.001 0.9780.80C
G = 0.998G = 0.999
121415115944423595444T/CT = 0.001T = 0 0.9910.00T
C = 0.999 C = 1.000
24733825945223595452G/AG = 0.999G = 0.9990.9170.55G
A = 0.001A = 0.001
120381665975323595753A/GA = 0.001A = 0.0020.9076.61G
G = 0.999G = 0.998
66669086076623596766C/AC = 1.000 C = 0.999 0.9080.50C
A = 0.000A = 0.001
120411596113523597135G/CG = 0.37G = 0.2640.0007620.61G
C = 0.630 C = 0.736
120315926133923597339A/CA = 0.483A = 0.5430.151.27C
C = 0.517 C = 0.457
10625986192223597922C/TC = 0.999 C = 1.000 0.8742.87T
T = 0.001 T = 0.000
117146194223597942C/TC = 0.152 C = 0.143 0.7210.93C
T = 0.848 T = 0.857
32035936195823597958A/GA = 0.002A = 0.0010.9120.30A
G = 0.998G = 0.999
10424366206823598068T/CT = 0.001 T = 0.002 0.9811.21C
C = 0.999 C = 0.998
20763436260123598601A/GA = 0.809A = 0.7370.007470.66A
G = 0.191G = 0.263
121315396266123598661G/AG = 1.000G = 1.0000.9190.06G
A = 0.000A = 0.000
115839356288223598882T/GT = 0 T = 0.001 0.934G
G = 1.000G = 0.999
121402636394923599949A/CA = 1.000A =
C = 0C =
38352256473223600732—/AG— = 1.000— = 1.000 0.9970.92—
AG = 0.000AG = 0.000
24733746514523601145C/TC = 0.001 C = 0.002 0.9531.72T
T = 0.999 T = 0.998
22561796578023601780A/GA = 0.658A = 0.6020.06930.79A
G = 0.342G = 0.398
9746986626023602260C/TC = 0.437 C = 0.499 0.05011.28T
T = 0.563 T = 0.501
10183966708723603087C/TC = 0.447 C = 0.522 0.01881.35T
T = 0.553 T = 0.478
7193996793723603937G/AG = 0.206G = 0.2060.991.00A
A = 0.794A = 0.794
7194006819623604196G/AG = 0.901G = 0.9310.1121.49A
A = 0.099A = 0.069
25029866876723604767G/TG = 0.453G = 0.5180.05051.29T
T = 0.547 T = 0.482
66793786948223605482T/CT = 0.741 T = 0.696 0.1320.80T
C = 0.259 C = 0.304
24733757002023606020C/TC = 0.469 C = 0.522 0.1171.24T
T = 0.531 T = 0.478
24733767275923608759A/GA = 0.002A = 0.0020.9910.95A
G = 0.998G = 0.998
12136455729112360891 1G/CG = 0.999G = 0.9970.8820.59G
C = 0.001 C = 0.003
25029877333123609331C/AC = 0.946 C = 0.944 0.9340.96C
A = 0.054A = 0.056
115517677425023610250C/TC = 1.000 C = 0.999 0.9220.46C
T = 0.000 T = 0.001
115912057448623610486T/CT = 0.133 T = 0.139 0.8171.05C
C = 0.867 C = 0.861
120832987492123610921A/TA = 0.001A = 0.0010.990.52A
T = 0.999 T = 0.999
121386047506523611065G/AG = 0.682G = 0.6880.8251.03A
A = 0.318A = 0.312
121360427507723611077C/TC = 0.981 C = 0.978 0.8730.88C
T = 0.019 T = 0.022
121386067507823611078G/AG = 0.002G = 0.0030.9691.38A
A = 0.998A = 0.997
121360457509623611096C/TC = 0.705 C = 0.698 0.7950.96C
T = 0.295 T = 0.302
121165967510823611108C/GC = 0.002 C = 0.001 0.9940.94C
G = 0.998G = 0.999
121386107512123611121A/GA = 0.586A = 0.5780.7870.97A
G = 0.414G = 0.422
121360697513623611136T/CT = 0.286 T = 0.294 0.7891.04C
C = 0.714 C = 0.706
121166177515023611150C/TC = C = 0.697
T = T = 0.303
75400567559423611594G/AG =G = 0.996
A =A = 0.004
120444527712023613120T/GT = 0.001 T = 0.055 0.0064557.90G
G = 0.999G = 0.945
20763447740723613407G/AG = 0.893G = 0.9010.7071.09A
A = 0.107A = 0.099
115881877852223614522T/AT = 0.509T = 0.57 0.06841.28A
A = 0.491A = 0.430
66969327865623614656T/AT = 0T = 0 1T
A = 1.000A = 1.000
120255317890223614902T/CT = 0.004 T = 0.003 0.9050.67T
C = 0.996 C = 0.997
66828887891123614911G/AG = 1.000G = 1.0000.9350.19G
A = 0.000A = 0.000
29823908130523617305G/CG = 0.487G = 0.57 0.01511.40C
C = 0.513 C = 0.430
21793948171723617717A/TA = 0.999A = 0.9970.8590.57A
T = 0.001 T = 0.003
24733778173523617735C/TC = 0.58 C = 0.546 0.2790.87C
T = 0.420 T = 0.454
21793958184023617840T/CT = 0.564T = 0.63 0.05271.32C
C = 0.436 C = 0.370
25029788251123618511C/TC = 1.000 C = 1.000 0.980.47C
T = 0.000 T = 0.000
25029798279023618790A/CA = 0.686A = 0.6290.08050.78A
C = 0.314 C = 0.371
66985358332323619323T/AT = 1.000 T = 1.000 1
A = 0A = 0
25029808346423619464T/CT = 0.948T = 1000 0.0305C
C = 0.052C = 0
66978058547123621471A/CA = 0.687A = 0.7740.003121.56C
C = 0.313 C = 0.226
64241148568823621688C/AC = 0.002 C = 0.002 0.9430.69C
A = 0.998A = 0.998
57730588619623622196—/TT— = 0.547— = 0.491 0.09060.80—
TT = 0.453TT = 0.509
46491148632323622323T/GT = 0.003 T = 0.004 0.9771.08G
G = 0.997G = 0.996
64241158670623622706A/GA = 0.632A = 0.5910.2130.84A
G = 0.368G = 0.409
1055424283916-23619916{circumflex over ( )}CACT/—CACT = 0.476CACT = 0.541 0.04581.30—
8392023619919— = 0.524— = 0.459
|
FIG. 1E shows proximal SNPs in and around the HT014/LOC148902/LYPLA2/GALE region for females. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIG. 1E can be determined by consulting Table 40. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.
To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10−8 were truncated at that value.
Finally, the gene or genes present in the loci region of the proximal SNPs as annotated by Locus Link (http address: www.ncbi.nlm.nih.gov/LocusLink/) are provided on the graph. The exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.
Example 16
DPF3 Proximal SNPs
It has been discovered that a polymorphic variation (rs1990440) in the DPF3 gene is associated with the occurrence of breast cancer (see Examples 1 and 2). Subsequently, SNPs proximal to the incident SNP (rs1990440) were identified and allelotyped in breast cancer sample sets and control sample sets as described in Examples 1 and 2. Approximately 627 allelic variants located within the DPF3 gene were identified and allelotyped. The polymorphic variants are set forth in Table 41. The chromosome position provided in column four of Table 41 is based on Genome “Build 34” of NCBI's GenBank.
TABLE 41
|
|
Position inChromosomeGenomeDeduced
dbSNP rs#SEQ ID NO: 6ChromosomePositionAllele VariantsLetterIupac
|
|
118462742071471066357g/aaR
25269354861471066636t/gaM
92932817451471067895t/caR
374284019221471068072a/gtY
967173921901471068340a/ccM
800620825901471068740c/tcY
800623026371471068787t/ccY
800783628041471068954c/ttY
800688928061471068956g/agR
801082328951471069045c/tcY
801102931091471069259a/taW
1064992031851471069335—/aaaN
280395633551471069505a/gaR
280395736421471069792c/ttY
252693438051471069955t/caR
967155842361471070386a/ggR
252693343311471070481c/gcS
280395945091471070659t/ctY
252693249591471071109c/taR
280396050091471071159g/aaR
1243467556761471071826g/agR
489943565071471072657g/ccS
252693166951471072845c/taR
280396167171471072867t/ctY
280396271311471073281c/tcY
1259063478731471074023c/tcY
1132771279221471074072—/ccN
280396386521471074802a/ggR
1184483498171471075967g/agR
11320415102721471076422—/aaN
8012752108231471076973t/ccY
11623878114651471077615t/ccY
11623926116391471077789c/tcY
12434442121771471078327t/ccY
2526930126041471078754g/acY
12435306133631471079513g/aaR
10144028134541471079604c/gcS
4899436135401471079690c/tcY
7140593139231471080073a/caM
2107687145071471080657t/caR
991882165501471082700c/atK
3327176411471083791c/ttY
2526928189031471085053t/caR
7401336193951471085545a/gaR
2526926195271471085677t/aaW
994760203691471086519t/caR
994759205051471086655g/taM
994758205621471086712c/tgR
11848404209071471087057a/ttW
2526925209491471087099c/taR
11844236212781471087428t/ggK
2526924213141471087464c/taR
2803965219051471088055c/gcS
2526923222521471088402g/cgS
7152467229411471089091c/tcY
11623462235421471089692c/ggS
2803966246771471090827c/tcY
2526922250091471091159t/caR
2526920256181471091768c/taR
11848135260821471092232t/ctY
11629210261361471092286c/acM
2803967264911471092641c/ttY
16455288731471095023—/gccgN
757655288861471095036g/acY
5809581291051471095255—/tctgtaattN
3057139291061471095256—/ctgtaattcN
2247658295721471095722c/ttY
11625609306401471096790c/tcY
8005580308011471096951a/gaR
8010472309621471097112g/agR
2526919316621471097812t/caR
2803968343741471100524g/aaR
11623943344941471100644t/ccY
11623946345011471100651g/ccS
1557926345441471100694c/gcS
12434611354931471101643a/ggR
2526918355941471101744t/gaM
5809582359011471102051—/ttN
8008279359401471102090c/gcS
2803969360641471102214t/ctY
2526917361051471102255t/gaM
8008774361601471102310t/ccY
2803970361611471102311t/gtK
8010255363081471102458t/ctY
2997642363351471102485a/gaR
2803971363651471102515g/aaR
11313760364881471102638—/ggN
2803972365761471102726g/ttK
4903038366411471102791a/ggR
2526916369331471103083a/ttW
4903040369551471103105c/tcY
2803974369671471103117t/atW
2803975372431471103393c/ttY
2803976383291471104479c/ttY
2803977383671471104517t/ggK
10139909384761471104626c/ttY
722945385101471104660g/acY
917069393961471105546a/gtY
2803978397031471105853c/aaM
2332890398011471105951a/ggR
1989638400781471106228t/cgR
10679174402601471106410ggg/—gN
2526915405131471106663c/taR
2526914408891471107039t/cgR
11158964410911471107241g/agR
11158965418721471108022a/gaR
740081421121471108262a/gcY
740080422921471108442t/gaM
10140582423731471108523t/ccY
2526913448771471111027a/gcY
4899437451241471111274c/gcS
10145678458311471111981t/ctY
2107686460301471112180t/cgR
2107685462701471112420t/caR
2107684463091471112459g/acY
7154188465451471112695c/ggS
4903041471621471113312c/tcY
7159637472671471113417t/ccY
6574089490771471115227a/gaR
12589753493771471115527a/ggR
4899438501261471116276g/ccS
4903042503851471116535g/tgK
4903043504031471116553a/ttW
2803980504221471116572g/aaR
10483848508931471117043t/aaW
2240344520311471118181g/ccS
2286068522451471118395a/gtY
11339669525941471118744—/ggN
3854528741471119024a/gtY
11463530111471119161t/gcM
1383536561471119806a/ttW
1381536621471119812c/gcS
1377537111471119861t/caR
11158966537981471119948a/ggR
11158967538401471119990a/ggR
11158968538731471120023c/tcY
11158969538841471120034a/ggR
11158970539371471120087a/ggR
11158971540321471120182g/agR
11849782543521471120502c/ggS
10137616554301471121580c/ttY
757572559201471122070g/acY
10140566560811471122231g/ttK
2023480562271471122377a/ttW
2526911573501471123500t/atW
4903044574931471123643c/tcY
11845162576821471123832g/cgS
12147210580921471124242c/tcY
2997643587311471124881g/tgK
2997644588261471124976a/taW
3814867609161471127066t/caR
2286067620471471128197a/gtY
1060570620801471128230t/gcM
2332891626651471128815c/gcS
2021736628091471128959g/atY
7160830636291471129779t/ccY
2526909654321471131582a/gtY
7140963655901471131740g/cgS
10143667658761471132026a/ggR
2803981671181471133268t/ccY
768840673481471133498t/cgR
5809587682301471134380t/—tN
2023479682621471134412a/gcY
4903045689121471135062t/ccY
4903046697991471135949a/ggR
5809588700271471136177—/ggN
10220555733351471139485g/a9R
2906132740931471140243g/acY
11848482741141471140264t/gtK
10129954745921471140742t/ccY
2526921750611471141211c/taR
4903047756831471141833g/tgK
11846357758571471142007a/gaR
10136385764571471142607g/ccS
12588242771301471143280t/aaW
11621517779471471144097c/ttY
2526910783381471144488c/tgR
2526941796261471145776a/gtY
2803944804971471146647g/agR
12436770805781471146728a/ggR
10220279811711471147321c/acM
10220280812431471147393g/ccS
11844112813211471147471a/ccM
12432455826341471148784g/cgS
8015338832691471149419g/agR
3832969835141471149664cagc/—aN
9671972853671471151517a/gaR
9671975854231471151573c/tcY
7159986860061471152156t/ccY
11848220865151471152665t/gtK
5016369869361471153086g/ccS
1986423872011471153351a/gaR
2332909872051471153355c/tcY
8013337883131471154463g/aaR
11445680894771471155627—/gaN
4903048902431471156393t/ccY
12434793907351471156885t/ccY
2332910919901471158140g/cgS
4410017928791471159029a/ggR
4577019928801471159030a/gaR
2332911933861471159536a/ggR
4996747933971471159547t/gtK
10140820936801471159830g/ttK
12431623955851471161735t/ctY
6574090958181471161968g/ttK
8008750962031471162353c/ggS
11627420969111471163061g/agR
10150185980141471164164a/ggR
10150218982291471164379a/ccM
9646164982351471164385t/ggK
6574091991731471165323c/ttY
23329121005051471166655a/ggR
71553591016131471167763a/gaR
23329131016601471167810c/tcY
45441841016811471167831g/ttK
43372241021651471168315g/agR
23329141037631471169913c/ttY
42801671049901471171140g/agR
49030491053191471171469g/ttK
37428371054471471171597t/gcM
101399371054711471171621a/gaR
124342921055151471171665a/gaR
116206711055981471171748a/ttW
101401841056741471171824c/acM
23329151064321471172582c/ggS
23329161069881471173138c/tcY
80127591070761471173226c/tcY
101492721079911471174141g/ccS
111589731082211471174371a/gaR
49030501084101471174560g/ttK
106664451087621471174912ctta/—cN
25361431089241471175074a/taW
106382311093781471175528ttttttttttttt/—tN
124316361094421471175592a/ggR
80059041096191471175769c/ttY
116210581098201471175970c/tcY
101332241105301471176680t/ccY
124331851109561471177106a/taW
7409741119651471178115a/gaR
7409731119951471178145g/ccS
7409721120401471178190t/ccY
7409711120581471178208a/gaR
42436421125921471178742c/ggS
44159521130441471179194c/ttY
22155891132631471179413g/atY
434321 11133011471179451t/ccY
25361421135131471179663t/cgR
112933401136391471179789—/aaN
101516201140921471180242c/gcS
22868401144321471180582t/gaM
80230891146431471180793t/aaW
80080091149801471181130g/agR
114190891153121471181462—/ttN
106946761153151471181465—/tttN
25361411153771471181527c/tgR
7652471156251471181775c/atK
71476261157401471181890t/ctY
101326291157471471181897g/agR
49030511158901471182040c/ggS
111589741172791471183429t/ccY
10350211175221471183672c/atK
65740931187211471184871t/ggK
48994391199261471186076t/ccY
71552871199741471186124t/atW
71544021202811471186431a/gaR
71547811204841471186634g/aaR
65740941223971471188547c/ttY
101322421227831471188933g/aaR
101469591230291471189179t/ctY
101474661235351471189685t/ctY
116264111241071471190257g/cgS
48994401244271471190577c/tcY
101445531247381471190888t/ccY
116276631253291471191479a/ccM
116277991257961471191946a/gaR
118517331262651471192415g/agR
101403171267681471192918a/ttW
80073751273061471193456c/ttY
48994411275441471193694g/aaR
111589751278091471193959a/ccM
114196071278171471193967a/—aN
21097931297711471195921c/ggS
80231561300611471196211g/cgS
101405791303331471196483g/aaR
71481991317341471197884t/ctY
71469161317871471197937g/aaR
19904391326331471198783g/acY
65740951352791471201429c/gcS
101400371357091471201859t/aaW
80072491362081471202358a/ggR
19904381370911471203241a/gcY
19904371374991471203649t/caR
101464841377051471203855a/gaR
116273331377261471203876a/ccM
71558021379441471204094g/aaR
21097921381751471204325t/gcM
114293631382241471204374a/—cN
80042101393191471205469a/ggR
20981941394091471205559c/tgR
21097911395971471205747t/gcM
113817291404761471206626—/aaN
11600941408081471206958c/tgR
116280511413631471207513a/ttW
101367711416551471207805g/agR
101399031427151471208865a/ccM
49030531432531471209403c/tcY
37428361439111471210061t/caR
37428351440441471210194g/acY
80032331446701471210820t/ggK
116215881449611471211111c/tcY
7409811466131471212763g/cgS
80194921474131471213563c/aaM
80196441474641471213614g/aaR
80196461474681471213618g/aaR
80196531474791471213629a/gaR
114507941474881471213638a/—gN
113481931475001471213650—/aaN
114507931475271471213677g/—aN
112827351475341471213684aagagaagag/—gN
21918231495731471215723g/taM
122322201507981471216948a/ggR
111589761541691471220319c/tcY
49030541550561471221206c/tcY
118467551554941471221644t/ctY
124319881577561471223906g/agR
121005261578301471223980t/ccY
116225681583791471224529a/ccM
96712301599061471226056c/ttY
121474871599511471226101a/taW
49030551601351471226285t/ctY
121475151602091471226359g/agR
116250921603511471226501c/tcY
48994421608351471226985t/gtK
20521461611101471227260a/cgK
102205531613461471227496a/taW
102205651616701471227820a/ggR
23329171634471471229597g/ccS
71589101634791471229629g/agR
80157491643771471230527a/gaR
80068121663281471232478a/gaR
80083381663611471232511c/ttY
20521451670031471233153t/gaM
20521441670361471233186t/gcM
101466921677591471233909a/ggR
116273051678291471233979a/gaR
20799891683601471234510c/taR
80188811685821471234732c/acM
45613871694621471235612a/taW
116220251703171471236467a/ccM
7409801706691471236819a/ggR
124332501712951471237445t/ccY
58095901713951471237545—/aaN
7589151714311471237581t/caR
7589141716261471237776a/ttW
71542291717351471237885g/agR
124371881719721471238122t/ctY
71591081722581471238408t/aaW
49030581724481471238598g/ccS
48994431729181471239068c/aaM
118489071734151471239565a/ggR
124321481734671471239617g/ttK
124350781736971471239847c/tcY
65740961739911471240141a/gaR
111589771740911471240241t/aaW
116294341745711471240721g/tgK
43785631777801471243930c/tcY
20981951781291471244279c/gcS
46336531786931471244843c/acM
71483501793251471245475g/agR
7409791795111471245661a/taW
7409781796081471245758g/cgS
7409771796441471245794a/gtY
7409761798081471245958t/caR
49030591800411471246191c/ttY
49030601814201471247570g/aaR
118520561814231471247573a/ggR
96352571819321471248082c/tcY
96352581819921471248142c/tcY
96352591822481471248398a/gaR
48994441823351471248485g/aaR
124353821842681471250418g/agR
124354121843661471250516g/agR
116273811848551471251005g/aaR
20521431855321471251682g/atY
20521421856331471251783g/atY
20521411857171471251867c/taR
80210351866371471252787a/ggR
111589781870101471253160a/gaR
116212161873671471253517a/taW
101308731875241471253674t/ccY
116213581875251471253675g/agR
7589131883521471254502a/gtY
116226021883601471254510a/ggR
101369311890321471255182c/tcY
7409751891001471255250t/gaM
7479871894441471255594t/ccY
116238191894501471255600c/tcY
124344451904311471256581c/aaM
80033751908131471256963t/aaW
101435961909831471257133a/ggR
124353211914931471257643t/ccY
124354011915881471257738a/ggR
80106091917641471257914t/ctY
111589791918111471257961g/ccS
111589801921261471258276c/ttY
116275241923561471258506c/acM
11261601929531471259103a/ctK
101360741941331471260283g/ccS
49030611953331471261483t/aaW
106653981956571471261807—/caaN
65740971956681471261818a/caM
96716541956761471261826c/ggS
101400241958051471261955c/tcY
101424211959981471262148g/aaR
101425931960661471262216c/tcY
114233721964151471262565—/caN
58095921964171471262567—/ccN
23329181965381471262688c/ttY
23329191965691471262719t/ccY
80073481966211471262771a/ccM
19904431968061471262956g/acY
80076901968231471262973c/gcS
39374551972041471263354g/cgS
80128231974351471263585c/tcY
48994451976121471263762g/aaR
49030621978541471264004c/ttY
9739631982641471264414g/atY
101499621988351471264985t/ggK
80034491992751471265425a/gaR
116207751993361471265486c/tcY
80090891999031471266053a/ggR
80089672000171471266167t/ccY
120501322001411471266291a/taW
101330182005521471266702t/ccY
19904422008681471267018t/caR
19904412009831471267133t/gcM
80158332009901471267140c/ttY
19904402010451471267195g/cgS
49030632024261471268576c/ggS
101398102028411471268991c/acM
49030642033111471269461t/ctY
21597152035431471269693a/cgK
21097952037491471269899a/gtY
21597142040401471270190g/acY
116231072042691471270419a/ccM
71520052043091471270459c/tcY
71524892044261471270576a/ggR
44791672051351471271285g/cgS
46066552052691471271419t/ccY
46066562053231471271473t/ccY
44899432053641471271514a/ggR
71426422063101471272460g/ccS
80062332066001471272750a/ggR
80075592067861471272936t/atW
80061562067961471272946a/gaR
14686622076331471273783a/gcY
116270482077231471273873g/agR
65740982080261471274176t/ctY
124337602086271471274777c/ttY
124337802086621471274812c/ttY
124345062091091471275259t/atW
124346732097421471275892t/ctY
124314002097501471275900t/ccY
124313842098171471275967g/aaR
49030672101911471276341c/ttY
23329202103491471276499g/aaR
22155912107241471276874a/gtY
124330642115371471277687c/acM
124362632115511471277701t/gtK
124330972116591471277809g/aaR
124331842117571471277907g/tgK
80159002118211471277971a/ttW
112969812122361471278386t/—tN
113440252122371471278387t/—tN
114642042124421471278592—/atN
114411722124451471278595—/taN
113818072124551471278605t/—tN
108732512127301471278880g/aaR
21097942127461471278896t/cgR
108732522128361471278986t/ctY
45207842128861471279036g/agR
28778202130281471279178a/ttW
28778212130291471279179a/ttW
45691952130951471279245c/gcS
116289052142471471280397a/ccM
21918222148071471280957t/caR
21918212149211471281071a/ctK
114646892151631471281313t/—tN
124319592154061471281556g/agR
49030682160691471282219a/gaR
15445792168491471282999t/caR
71558792171301471283280g/tgK
124336032171431471283293c/gcS
113514322176571471283807a/—aN
114484382177251471283875—/ggN
42436432184351471284585g/agR
41409522187171471284867t/caR
80053722188121471284962c/ttY
80041092188261471284976t/ccY
80083982188721471285022a/ccM
80096922188901471285040t/ctY
23329212189441471285094c/acS
120503202192291471285379a/ggR
120503232193001471285450a/ggR
80103162197571471285907a/ggR
71542932205331471286683t/ctY
121479692215341471287684c/tcY
22155902216321471287782g/acY
42657492222341471288384c/tcY
10045522222411471288391c/taR
43078922224581471288608g/agR
124319732227351471288885t/ggK
124319752227491471288899a/ggR
7678742231871471289337t/ctY
116285972266261471292776g/ccS
101293712268651471293015a/gaR
49030692275481471293698a/caM
49030702276901471293840a/gaR
49030712278151471293965g/tgK
116222242284561471294606t/ccY
104594552290251471295175g/agR
93235772290851471295235c/tcY
106246482317571471297907ttg/—cN
30589532317621471297912gtt/—tN
111589812327271471298877t/ggK
111589822329551471299105t/gtK
111589832333021471299452g/ttK
18607502336291471299779t/atW
18607492336701471299820g/acY
18607482337021471299852a/ctK
18607472337151471299865a/gcY
114196792358271471301977—/aaN
80117772369511471303101t/ctY
65740992371571471303307a/gaR
80109572373171471303467a/gaR
116268952373631471303513g/agR
101514312388661471305016t/ggK
49030722397891471305939c/acM
45894892401701471306320t/ccY
96713272404301471306580g/tgK
48994462404541471306604c/ttY
101445012406881471306838t/atW
58095942414141471307564tg/—gN
7203172414241471307574a/gaR
80143162417411471307891g/aaR
111589842417681471307918t/ccY
64209062423601471308510c/tcY
80040552429571471309107a/taW
124348002433551471309505a/ggR
42436442435961471309746t/atW
48994472436481471309798a/gaR
49030732436641471309814g/aaR
118486342437831471309933t/ccY
48994482438191471309969t/ctY
101315642457651471311915a/ggR
101341502460891471312239t/ggK
7633882464571471312607a/gcY
118459382464851471312635a/ggR
118459462465361471312686g/tgK
118459152465861471312736t/ccY
101374632473561471313506a/caM
65741002475731471313723t/aaW
71403442481731471314323a/ggR
106468892489151471315065aa/—aN
71462872493441471315494c/tcY
10605948250079-2500821471316232cccc/—cNNNN
58095952505751471316725a/—aN
10350992507011471316851t/aaW
71598772512601471317410t/gtK
71425792518581471318008g/agR
124317622519811471318131g/agR
124317642519901471318140g/agR
106479992523261471318476agaaagaaag/—aN
65741012527271471318877c/tcY
65741022529461471319096t/ccY
18611622541991471320349t/cgR
124329722549851471321135t/ctY
101461342553241471321474a/taW
101466162556861471321836a/ccM
101467692557181471321868a/ggR
80189362563211471322471g/agR
104838492575621471323712g/aaR
21601372588431471324993t/caR
21925952588801471325030c/agK
21925942590601471325210a/gcY
112716952615901471327740tccatatggctgaggagg/—tN
107473012620881471328238g/ccS
120503632623451471328495c/ggS
120503682623681471328518g/agR
124329492638581471330008a/ggR
74013752639951471330145t/aaW
80196822651951471331345g/agR
80212482656201471331770t/ctY
111589852658331471331983t/aaW
104838502663871471332537a/gaR
80108752671301471333280a/ggR
116268442674681471333618t/ccY
9829722676061471333756a/gcY
71611982688581471335008t/ctY
71603472691931471335343g/aaR
80071392699911471336141a/gaR
80144832718401471337990c/tcY
124370722725921471338742t/ctY
80047672733991471339549c/gcS
125888302735041471339654a/ggR
71584492740501471340200t/ccY
65741032741821471340332c/tcY
80204782742751471340425c/tcY
49030772762931471342443c/ttY
80123592766451471342795g/aaR
48994492771661471343316a/ggR
106902892782901471344440aag/—aN
65741042786461471344796g/ttK
21105522790221471345172a/gtY
80082562790731471345223g/aaR
7592832801981471346348g/tcM
49991772811001471347250a/ggR
23330062811451471347295c/gcS
80061782826551471348805a/caM
111589862828361471348986a/caM
71506252835371471349687c/ttY
80077682839761471350126t/gtK
80070582841491471350299a/ggR
DPF3-AA2847421471350892c/aaM
22159012848401471350990c/taR
38148662849121471351062t/gaM
38148642850911471351241t/ccY
|
Assay for Verifying and Allelotyping SNPs
The methods used to verify and allelotype the proximal SNPs of Table 41 are the same methods described in Examples 1 and 2 herein. The PCR primers and extend primers used in these in Table 42 and Table 43, respectively.
TABLE 42
|
|
dbSNP rs#Forward PCR primerReverse PCR primer
|
|
11846274ACGTTGGATGTTCACTGTGATGTGGTTGCGACGTTGGATGAGGAACCACGAAAGAGTGGG
|
2526935ACGTTGGATGCATTGCCTCTTGCAGATGAGACGTTGGATGATGAAAGCTGTGTCAGACTC
|
929328ACGTTGGATGCCACAGAGAAGCTATAGCTCACGTTGGATGAAGCAAAATGCCTGGGCTTG
|
3742840ACGTTGGATGTGCTTGTCAGATCCTAGCTTACGTTGGATGCGGTTATTCCTAATGCTGTC
|
9671739ACGTTGGATGAGCTGCTTGTGGGTTTCTGGACGTTGGATGAGGGAAAAGACCACTGTGGG
|
8006208ACGTTGGATGAAGCAACTTGAAGGCTAGGCACGTTGGATGCAATGCTCTAGGTCCTGTAG
|
8006230ACGTTGGATGATTAAAACCCTTGGCAGGGCACGTTGGATGTGCGGTTTATTTTCCAGCCC
|
8007836ACGTTGGATGAGCTTGGATGGACTCTGTTCACGTTGGATGGAATGGTCAGATGCTTAGGG
|
8006889ACGTTGGATGGAATGGTCAGATGCTTAGGGACGTTGGATGAGCTTGGATGGACTCTGTTC
|
8010823ACGTTGGATGGCTTTCCCAAATGCCATGTGACGTTGGATGTTATCTCAGAGCAGAGGAGG
|
8011029ACGTTGGATGTGATAGATGCTAAGGAGTGGACGTTGGATGATGTTGAAAATGTGCACGGG
|
10649920ACGTTGGATGCTTAGCATCTATCACGGCAGACGTTGGATGTTGCCCTTCCATGTCTACTC
|
2803956ACGTTGGATGTTGCATCCCTTTGATAGCAGACGTTGGATGCCTTCGTTCACCTATGCTTC
|
2803957ACGTTGGATGGGTTCATTAAGTAGGGCGTGACGTTGGATGAGAACAGGAATGCCCATGTG
|
2526934ACGTTGGATGAGTCTGTAGGGTTGTGTTGCACGTTGGATGAGTGGGCCTTGTAGGAAATG
|
9671558ACGTTGGATGACAGAAGCTGGAACAAAGGGACGTTGGATGATTTGGAAGTGAGTGGGTTC
|
2526933ACGTTGGATGAGCTGTCAGGAAACTCTGAGACGTTGGATGGAGTTCCCTGTTCCTTCTAG
|
2803959ACGTTGGATGAAGGAGGGGAGAGGAAGATGACGTTGGATGTCTAAGGCAGTTCCCACTCG
|
2526932ACGTTGGATGCTCTTCCTGCTGTGTGTTGCACGTTGGATGTTCCCCTTCACCTGGTATCC
|
2803960ACGTTGGATGCTCTGCAAAGTGGACAGAGCACGTTGGATGCCTGGTATCCAAAAGCATGC
|
12434675ACGTTGGATGTTTTTAGCCTGTCGTGGAAGACGTTGGATGCTCTGGCCAGAGCCAACTTC
|
4899435ACGTTGGATGAGAACTTTGCTGGGCTTCACACGTTGGATGAACAGGATTTCCACTTCCGG
|
2526931ACGTTGGATGATCCAGCATGGTCTTTGCAGACGTTGGATGAATAGCTACCATGGAGTGGG
|
2803961ACGTTGGATGTCACATGTCTGTAAGGTGGGACGTTGGATGGGCCAGGATCTTTACCAATG
|
2803962ACGTTGGATGGGCTAATGCACACAAGAAGGACGTTGGATGTAAACAAGCACTGCAGAGCC
|
12590634ACGTTGGATGCTTTTAAGCTATTGTGGCACACGTTGGATGCTCCAAAGGCTAATAATTGG
|
11327712ACGTTGGATGAAAGCAGGCTGTCTCCAAAGACGTTGGATGTGGCACTTGGGAACATTTGG
|
2803963ACGTTGGATGTTCCAACACACAGAGTTCTCACGTTGGATGCCAAACATGCAGGACTCTTG
|
11844834ACGTTGGATGTGGAGATCCTAAAGCAGAGCACGTTGGATGTTTCCTTGCAGTTGGTCTGG
|
11320415ACGTTGGATGTCATCTCCACTGCATGTCTGACGTTGGATGAAACTGAGGCACAGTCCAAG
|
8012752ACGTTGGATGGAGGTGTTAGTCACAGAAGGACGTTGGATGATCCTACCCCCATTTTAGGG
|
11623878ACGTTGGATGTAAGTGCTGGGATTACAGGCACGTTGGATGTCCTTTACGTTACATGCCTG
|
11623926ACGTTGGATGACCTGTAATCCCAGCTACTCACGTTGGATGATCTTGGCTCACTGCAACCT
|
12434442ACGTTGGATGCTGCAATCTGATCGTATCACACGTTGGATGTTGTCATGCTAAAACCCGTC
|
2526930ACGTTGGATGTGAAGAGAGCAGGAGAGAAGACGTTGGATGTAGGACCTTCACTTGCCATC
|
12435306ACGTTGGATGAGGGATTTACCCTGGATATCACGTTGGATGATCCAGGAACCAGGAATCAC
|
10144028ACGTTGGATGCTGACCATGTGAGAGGAATCACGTTGGATGT1TGTTGACTTGGCAGAGCC
|
4899436ACGTTGGATGCTGTAAAGCCAAAGACCAGCACGTTGGATGTCATTCCTTCCTACAGCTGC
|
7140593ACGTTGGATGTAACCAAATTCATTTGCCTCACGTTGGATGGTAGAGAGCTACATTTCTTG
|
2107687ACGTTGGATGAAGTGATTCCAGGTCTGGAGACGTTGGATGGGATCCTGAGTCCTTTTGAC
|
991882ACGTTGGATGCTGCACCACAAATACTGTACACGTTGGATGTCTAGCATACGTAGTTTCAG
|
3327ACGTTGGATGGTTTCTGGTCCTTTGTCCTCACGTTGGATGTTTGGCAGCATGTACCACAG
|
2526928ACGTTGGATGCATGTTAAGAAGATATCCCACACGTTGGATGTGATTCTTTCCCTTTGTCAG
|
7401336ACGTTGGATGCTCTAGCCCTAACAATTGACACGTTGGATGCTCATGACTGTATTTGACTG
|
2526926ACGTTGGATGGGCCCATACATTGCAATTAGACGTTGGATGTGGAGGGAAAAGTCTATGTG
|
994760ACGTTGGATGAGGAAGCCAGAAACAACAGCACGTTGGATGGGGCATCAATGTGTTTCCAG
|
994759ACGTTGGATGGACGTAGGGAAAAAAATGGGACGTTGGATGTCTGTTTTGCCCTTGATCTG
|
994758ACGTTGGATGTCATCAACTGGTTACACCTGACGTTGGATGAGATCAAGGGCAAAACAGAG
|
11848404ACGTTGGATGACTTCCTTCTGTAGTCCGTGACGTTGGATGCCTAAAGTATCCATGCCCAC
|
2526925ACGTTGGATGCTTTTAGGATAGACCTGGCCACGTTGGATGACGGACTACAGAAGGAAGTG
|
11844236ACGTTGGATGCTTCTATGTGGCATGGAAGGACGTTGGATGTCTGGGCAGATTCTGATCTG
|
2526924ACGTTGGATGGTCAGTAATTGGCTTTGCCCACGTTGGATGTGGATGACATTCCCAAGTCG
|
2803965ACGTTGGATGCTAATAACCCTCTCAAGGTGACGTTGGATGTTTCAAGAATATCAGCTGGC
|
2526923ACGTTGGATGCCAGCCAGCTTAGGATAACTACGTTGGATGTTCTGTCTAGCACAATGGCC
|
7152467ACGTTGGATGGTACATGTAAAACTAGTCACACGTTGGATGAGCACAATATCAAAACCAGG
|
11623462ACGTTGGATGGAGGAAGGAAGGATGAAGGGACGTTGGATGCCTCCTAACTAGCTTCCTGG
|
2803966ACGTTGGATGTCTTCAAACCCGAAGCAAGGACGTTGGATGTGCTAAGGCCCATCTTAGTC
|
2526922ACGTTGGATGAATGAGACTTCTTACCTGCCACGTTGGATGGAACCTTAGAAACAAGCTGC
|
2526920ACGTTGGATGACACCAAGTTCACCACTGACACGTTGGATGCCCGGATGTTCCTCTAAATG
|
11848135ACGTTGGATGCGTGCATAGAAATTGGCAGCACGTTGGATGTTGAGTGAGAAGGCACACAG
|
11629210ACGTTGGATGGTTTCATATTCACAGCTGCCACGTTGGATGCCTAAAAGGCTGGAAATACC
|
2803967ACGTTGGATGTGATTGAATTAGGGCTCCAGACGTTGGATGAGACCATGCTGATTCCAAAG
|
16455ACGTTGGATGTGATTCTTGCCCCACAACAGACGTTGGATGATTGATGTTGGGCTCTGGGC
|
757655ACGTTGGATGAACAGTGTGTGAAGGTCAGGACGTTGGATGAGCAAATGTCAAGGCTTGGC
|
5809581ACGTTGGATGTCACTGCTGTTTTCCACCAGACGTTGGATGCTTCCTACTGTCCTGAGTAC
|
3057139ACGTTGGATGTCACTGCTGTTTTCCACCAGACGTTGGATGCTTCCTACTGTCCTGAGTAC
|
2247658ACGTTGGATGTGAGTAGCTGGGACTACAGGACGTTGGATGTAACACGGTGAAACCCCGTC
|
11625609ACGTTGGATGCAAGCTGGGCCTTAAAGGATACGTTGGATGTGCCTTTCCCTGTAATGCTG
|
8005580ACGTTGGATGGCAGGGAAAAGAGGAATTGCACGTTGGATGCATGCCTACATAAGAGGCTC
|
8010472ACGTTGGATGTGGATTTAGTGACTGGTCCCACGTTGGATGGAGATGAGTCTGGTGATAGG
|
2526919ACGTTGGATGAGGGAGAAGTATCTGGAGAGACGTTGGATGCATCTGTCACTTGATGGTGG
|
2803968ACGTTGGATGGGGAACACTTCTGTCCTTTCACGTTGGATGTGAGAGGAGCACAAAAGACG
|
11623943ACGTTGGATGATTGAAAGGAGCCAGTGAGGACGTTGGATGGGAAGGATCCCCTTTTTGTC
|
11623946ACGTTGGATGATTGAAAGGAGCCAGTGAGGACGTTGGATGGGAAGGATCCCCTTTTTGTC
|
1557926ACGTTGGATGAAATCGGGAGGTGGAGAATGACGTTGGATGACAATCGAGACACCCACAAC
|
12434611ACGTTGGATGAATCTGACCTCCTTTCAGGGACGTTGGATGTAATGTCTGCCCTGGGTATG
|
2526918ACGTTGGATGGTATGCAAACTCTAGACCAGACGTTGGATGCCAATCTGCATGGATAAGAC
|
5809582ACGTTGGATGAGAGTGAAACCCTATCTCTGACGTTGGATGGGTCACATACTTCTGTCTTC
|
8008279ACGTTGGATGTCAGAGATAGGGTTTCACTCACGTTGGATGGGTGCAGTGAACCAAGATTG
|
2803969ACGTTGGATGAAAATTAGCCAGGCATGGTGACGTTGGATGAATCCTTCCTCCTCAGCATC
|
2526917ACGTTGGATGATCCCTTCTTACCAGCTTGGACGTTGGATGTACAGGTATGTGCCACCATG
|
8008774ACGTTGGATGAGGAATGGGTTGATGCCTTCACGTTGGATGCCAAGCTGGTAAGAAGGGAT
|
2803970ACGTTGGATGCCAAGCTGGTAAGAAGGGATACGTTGGATGAGGAATGGGTTGATGCCTTC
|
8010255ACGTTGGATGCTTTTCTGTGGTATGGTGGGACGTTGGATGTAGCATTGCAAGCCTCTTTG
|
2997642ACGTTGGATGGCCACAGCTGCCTTTTTAAGACGTTGGATGGTGGGATGCGGCAAATACTT
|
2803971ACGTTGGATGAGTGAGAGACCTTTGTGTGCACGTTGGATGCCCACCATACCACAGAAAAG
|
11313760ACGTTGGATGCTCACTATCTCTCAACTCCCACGTTGGATGATGGGCCCACTTTTGTGTAG
|
2803972ACGTTGGATGTGCAGTCCCTAGGTCAGATCACGTTGGATGTACACTCCGGCTACACAAAA
|
4903038ACGTTGGATGACAAGATCCCCAGGTGATTCACGTTGGATGAGAGAGTGAAGACTGAGTGG
|
2526916ACGTTGGATGTTCTCTACCCTCTAACGCAGACGTTGGATGTTAGTGGCTGCAGAGCTGTA
|
4903040ACGTTGGATGACCAAAGTCCTGGGAGGATGACGTTGGATGACTCATGGGCTTGGAGTCAG
|
2803974ACGTTGGATGATCTGCTTACAGCTCTGCAGACGTTGGATGTCTGGATGCACTTCGTAAAG
|
2803975ACGTTGGATGCTGATGACTACTGCTTACCCACGTTGGATGCTGGGATGTGTGTTTGAAGG
|
2803976ACGTTGGATGGCAACCTAATTAGATTGCACCACGTTGGATGTTGGCTCAGGTATATTCCTC
|
2803977ACGTTGGATGAGCCCCAGAACAAGCATTACACGTTGGATGCTCGTGATTTTTGGCTCAGG
|
10139909ACGTTGGATGTTTATTGAGGGCAGTGAGGCACGTTGGATGTATGGTGAGAAGTGGTACTG
|
722945ACGTTGGATGTTCTTTAATCTCGCCAGGAGACGTTGGATGATAGGTGCATGAGCAGTGAC
|
917069ACGTTGGATGGCTTGTTTGTATGCTGGCTGACGTTGGATGCCTGAGAATTTTGCTCCTGC
|
2803978ACGTTGGATGTTATGTGGACTCACTTCCCCACGTTGGATGCAGAAAGAGGTTCATGCTGG
|
2332890ACGTTGGATGTTGTCATGGTGGTTGGGAACACGTTGGATGTGGGATGAGGATTTTCCCAC
|
1989638ACGTTGGATGAGAGTGAGGACAGAGAGAAGACGTTGGATGCCCTTCTTCTCTGTATCCTG
|
10679174ACGTTGGATGAGCGCCTCATAAAGTTGTAGACGTTGGATGCTCAATTGTCTCACTCATCC
|
2526915ACGTTGGATGTTCCCAGTGCTTGTTTCCTGACGTTGGATGGGCAGAGACAGGATGAAAAC
|
2526914ACGTTGGATGATAAAGGCCCTCCCTGAATGACGTTGGATGGATCCTCGCCTTTAACTCTG
|
11158964ACGTTGGATGGAAGGAAACAGACAGCAGAGACGTTGGATGAGAAAAGAGACTGGATAAAG
|
11158965ACGTTGGATGGGGCTGCTCCTTCTTCCTGTACGTTGGATGTTCTGATGTGCATTCATCCTT
|
740081ACGTTGGATGACTTTCTTCTTCCATCCCCCACGTTGGATGAGCCTCTCTAAGAAGTGCTC
|
740080ACGTTGGATGTCCCCAGATTTCTTTGCCTCACGTTGGATGTGGAGGTGGAATCTCCTTTG
|
10140582ACGTTGGATGACGTTGGCTGGCTGTGAGACACGTTGGATGAAGAGGCAAAGAAATCTGGG
|
2526913ACGTTGGATGGCAAGAGTGGGAAATACCTGACGTTGGATGATTCACGCTCATCTCTGCTC
|
4899437ACGTTGGATGTCCAGAACAGAAAAGGTGCCACGTTGGATGAAAGGCAGTGGTGATTGCTG
|
10145678ACGTTGGATGTCTGCTTCAGAAAAGAAGTGACGTTGGATGGGTACAATCCTTGCTACTTC
|
2107686ACGTTGGATGGAGGTCATTCAACCAAAATCACGTTGGATGACATCATCTTTGGTGCATGG
|
2107685ACGTTGGATGTGTCTTGCCACTGCATTCACACGTTGGATGCTGAAGCAATGTCTCAAGCC
|
2107684ACGTTGGATGGTCAACAAAAGGCTTGAGACACGTTGGATGGGAGAAGATTAGTTTCACGG
|
7154188ACGTTGGATGCCCCAACTCTATGCAAGAGAACGTTGGATGCAAGCAGTTCTTTTGACACC
|
4903041ACGTTGGATGGAAAGATCAGGTAACCAAACGACGTTGGATGGAGGAGAAAGAGTCTTCAAAC
|
7159637ACGTTGGATGCCAAGTTCTACCCTGTGATCACGTTGGATGGAAGACTCTTTCTCCTCCTG
|
6574089ACGTTGGATGGGTTCTAGTTACATGGAGTGACGTTGGATGGATGACCAGTTGTCTATTAC
|
12589753ACGTTGGATGAGTCAGGATACTGCTAGAGGACGTTGGATGGGCATGCCTTGTTCAGATTC
|
4899438ACGTTGGATGTATCTTTGGGCTGCTCACAGACGTTGGATGCATCCTGGATCTCCTCTATC
|
4903042ACGTTGGATGCCGCATTTAGCTTATCCACGACGTTGGATGGTCACTATAGGAAGTGGGTG
|
4903043ACGTTGGATGCCGCATTTAGCTTATCCACGACGTTGGATGGTCACTATAGGAAGTGGGTG
|
2803980ACGTTGGATGTCATTGCATGTGTAAACCGCACGTTGGATGTATAGGAAGTGGGTGATGTG
|
10483848ACGTTGGATGAAAAAAACCCTAAGGAGGGCACGTTGGATGCGTTATGCCTTGCATTATGG
|
2240344ACGTTGGATGAACACTGTGACTCAAGGACCACGTTGGATGTTTCCCTCCCTTGTAAGCAG
|
2286068ACGTTGGATGAATTCAGTTGCTGGTGGGAGACGTTGGATGTACATCCCATCGGCCAAAAC
|
11339669ACGTTGGATGATTCCTTCCTGAGCTAGACCACGTTGGATGAGGCAAGCCCCTTTTATCTG
|
3854ACGTTGGATGCTCTAAAGAAAAATGCCCCACACGTTGGATGTAAAAAGCCTGAGAGAGCAG
|
11463ACGTTGGATGGAACACAAACAAACTGATGGACGTTGGATGACTTTTGAAGTAGGAGGTAC
|
1383ACGTTGGATGAATCAGGGTAGTGTGTCCAGACGTTGGATGTAGCAACTGACCTGCCCTAT
|
1381ACGTTGGATGTAGCAACTGACCTGCCCTATACGTTGGATGAATCAGGGTAGTGTGTCCAG
|
1377ACGTTGGATGAAGAGATCAGCCAGGAATAGACGTTGGATGTACACCACCTGGGAATTGAC
|
11158966ACGTTGGATGGCAGAACTGGGTGTTAGCAAACGTTGGATGTAAAGGTCCTTTCTGGGGTG
|
11158967ACGTTGGATGTTCCCCTCCACTTAGAAACCACGTTGGATGTTTCTACTTGGATGGCAGGG
|
11158968ACGTTGGATGTAAAACACCCCAGAAAGGACACGTTGGATGGGCTGAATTGGTTCTATACC
|
11158969ACGTTGGATGTGATGTCATCTCTCTCCCTGACGTTGGATGCAAATGAGGCATCTGATGGG
|
11158970ACGTTGGATGGGTATAGAACCAATTCAGCCACGTTGGATGAAGGAAGCAGTGTCCTTTTG
|
11158971ACGTTGGATGTGGAACTGGTCTCTTGGTTGACGTTGGATGTCACAAGCACTCACACTCAG
|
11849782ACGTTGGATGTAAGCTGAGCGATAAGGGAGACGTTGGATGGAGCTTTTTTCCTTGCTGGC
|
10137616ACGTTGGATGTTATGGCACACTGGTGTCAGACGTTGGATGAACAGATGGCGTGTTCCTTG
|
757572ACGTTGGATGTCCTATCCTTGACAGTGCTGACGTTGGATGACCTCGGTTCATTTGGCAAC
|
10140566ACGTTGGATGTGTTGTATCCTTCTCAGTGCACGTTGGATGAAAGGCCAAATGTCTGAGTC
|
2023480ACGTTGGATGAACAGCATCCAAGCCTGAACACGTTGGATGCCATGTCCTCTTACAAGTCC
|
2526911ACGTTGGATGGGTGTCTTTGATCTGGTGTGACGTTGGATGAATVCACACAGGGAGCTGAG
|
4903044ACGTTGGATGCCTAACAGATGAGTCTGCTCACGTTGGATGCCCAGTATACCTCCTGTTAC
|
11845162ACGTTGGATGCATCCCTTTAAGGGTTCCTGACGTTGGATGCCCTCCAGTGCTGTATAAAG
|
12147210ACGTTGGATGTTACTGAGCTGAGGGCAAAGACGTTGGATGACACACCTTTCTGTTGTTGC
|
2997643ACGTTGGATGTGTCCTTGGTTTCCAACCACACGTTGGATGCCCAGAATAATGCCTCACAC
|
2997644ACGTTGGATGAGTTAAGTTGGAGGGACTGGACGTTGGATGTCTTCTCTCGGAGCTTCCTT
|
3814867ACGTTGGATGATCCCTGCATTTGGAAGTCGACGTTGGATGCGTCAGTAGAGCTGCTGTTT
|
2286067ACGTTGGATGACCGGGTTAATCCCTTTGGTACGTTGGATGTGGGTTAAGCAACAGACAGC
|
1060570ACGTTGGATGAAGCCTCTTCCCTGGAAATGACGTTGGATGGCACACCAAAGGGATTAACC
|
2332891ACGTTGGATGGATCTGCATCCACATACATGACGTTGGATGTAACCGATACCTGGGCATGG
|
2021736ACGTTGGATGCCCTAATAAATCAGAGCATCCACGTTGGATGTTATACAAGAGCAGTCCTGG
|
7160830ACGTTGGATGTCAAGGGTGGTCCATTTGTGACGTTGGATGTGTCTTCTACGCTAGCATCC
|
2526909ACGTTGGATGAAATGACCTCCCATCAGTGCACGTTGGATGCATTGGGAACAGTGCTCTTG
|
7140963ACGTTGGATGTAGAAGCCTGGGTCTAGTTCACGTTGGATGGAAGTCCAGACCCATTGATC
|
10143667ACGTTGGATGAATAGCACCTGTCCTTATGCACGTTGGATGGGAAGTATTTCTCTCCATGC
|
2803981ACGTTGGATGGGGAGCTGCAATTCAAGATGACGTTGGATGCCTCATGACGTATGAGGATG
|
768840ACGTTGGATGAAGATGTGCCTTTGCTCCTCACGTTGGATGTAATGGACTCACAGTTCCAC
|
5809587ACGTTGGATGACTGTGCCACCCACTAACATACGTTGGATGTCTAACCCGTTGTTGGAACC
|
2023479ACGTTGGATGGCAGTGAATGATATCCGGTGACGTTGGATGGTGACTTTAGAGAGGGATGG
|
4903045ACGTTGGATGGCTTTGGGCTTCGTAAATATCACGTTGGATGAAACACTTTGCAGCCATACC
|
4903046ACGTTGGATGTCCATAAAACTACCGCCCAGACGTTGGATGCCTGCCAGTCATTCTTTCTG
|
5809588ACGTTGGATGAGGGCCTGGTGTGCACAAATACGTTGGATGTCCAGAAATGGAGCTGCTCA
|
10220555ACGTTGGATGTGACTCTCAGCACCAACTTCACGTTGGATGAGACCTGAGGATTTGGAAGG
|
2906132ACGTTGGATGGGCTTTAATTGGTGTGACAGACGTTGGATGATGGCATCTATCTCATAGGC
|
11848482ACGTTGGATGATGTCACCCGGAAGTCATTCACGTTGGATGCCATATGCCTCATGGATCAC
|
10129954ACGTTGGATGCACTCTCATGCTCTCAACACACGTTGGATGCAGATGCAAAACACAGACCC
|
2526921ACGTTGGATGAAAAGCTTGAGCCTGAAGTGACGTVGGATGAGAGAGGGAGAAAATGTAGG
|
4903047ACGTTGGATGAAATTCCATCGACTGGGTGGACGTTGGATGCCTTGATCTTGGACTTCCAG
|
11846357ACGTTGGATGTTAAGGGACATCGGTAGGACACGTTGGATGATGTCAGGACTTTGGAACCC
|
10136385ACGTTGGATGAAGCCATTGCCCTAGGATTGACGTTGGATGTTAGGCCCAAAATGCGAGAG
|
12588242ACGTTGGATGACTGGAAGATGGCAGATTGCACGTTGGATGTCTACATCCTTGACCCTGTG
|
11621517ACGTTGGATGAATTTCCCTCTTAGGAGCTCACGTTGGATGCATCTGTTTGGAGTCTTATTG
|
2526910ACGTTGGATGTTAGGACTACTGCATTAGGGACGTTGGATGTCCTTCTCATTCTCCAATGG
|
2526941ACGTTGGATGAATCCACTGCCACTCCTGATACGTTGGATGTGAGAGACTGAGGGAGAAAC
|
2803944ACGTTGGATGCCAGAATCCTCACAAACACCACGTTGGATGCCCACTAGCAAAACTGGGTT
|
12436770ACGTTGGATGTCTGGAACCTTCTTCGTGTGACGTTGGATGGCCAAGGGTTTAAAACCTCC
|
10220279ACGTTGGATGCACATATGCACATGTGCACACACGTTGGATGGCGTGTGTATACGTGTTGTG
|
10220280ACGTTGGATGTGTAGCCTCATTATGAGCCGACGTTGGATGCACAACACGTATACACACGC
|
11844112ACGTTGGATGTCCTTTATTCATGCCCTGGGACGTTGGATGAATGAGGCTACAGGAGAACC
|
12432455ACGTTGGATGATAAAGAACACACCTGTGGCACGTTGGATGAGAAGGCAATATTACGAGGG
|
8015338ACGTTGGATGCACACATTCGAAATGCCTGCACGTTGGATGCCCCTCTACAACAAAACCAC
|
3832969ACGTTGGATGATGTGCTGTAGTGTGTTGGCACGTTGGATGATTGCTAAGCCTAGGGTTGG
|
9671972ACGTTGGATGGGTGGATTTAGTGTTTCACTGACGTTGGATGGCAGGAATAAGAAGAACTAC
|
9671975ACGTTGGATGGTTTAGAACGATGTATCTGGCACGTTGGATGAGATGCTGAAAGGGTAGTTG
|
7159986ACGTTGGATGATAGTCACTGGGTCACCAACACGTTGGATGAAGAGGGACTTTGACCCTTG
|
11848220ACGTTGGATGATTCTCTCTTCCTCTCTCTCACGTTGGATGCCTGAGTCACATGGAATTAAG
|
5016369ACGTTGGATGAATGGAGTTGTCCAGAACAGACGTTGGATGTCACTGTTGCTTAATCACAC
|
1986423ACGTTGGATGATACAGAACCATTTTGTGGGACGTTGGATGAGCTTAATGTGGGTAGAAGG
|
2332909ACGTTGGATGCAGAACCATTTTGTGGGAAGACGTTGGATGGAGCTTAATGTGGGTAGAAG
|
8013337ACGTTGGATGTGCACAAGTCCTCATTGTTGACGTTGGATGGATTGTAGGGCAGAATATGG
|
11445680ACGTTGGATGTGTATGCATCTCTCCCACTGACGTTGGATGTTGAGCACCTGCCACAAGTG
|
4903048ACGTTGGATGACTTGAAGCACTTGGAGTGGACGTTGGATGAATGACACCACCAGTCACAG
|
12434793ACGTTGGATGGCCAGTCAAAGCAGGATTTCACGTTGGATGGAGGAAGAGTGAAGACTTCC
|
2332910ACGTTGGATGATTGGGAAGTGGGCAAACACACGTTGGATGTTGCCTTCTCTTTCTCCTTC
|
4410017ACGTTGGATGTTGCTCTCGGCAAGAAGGAGACGTTGGATGTGTATAGCACAGTGCCCAGG
|
4577019ACGTTGGATGTTGCTCTCGGCAAGAAGGAGACGTTGGATGTGTATAGCACAGTGCCCAGG
|
2332911ACGTTGGATGTACTTCCAAAAGCCACCTGCACGTTGGATGAAAAGCCTGGCCAGTTGAAG
|
4996747ACGTTGGATGTACTTCCAAAAGCCACCTGCACGTTGGATGAAGCCTGGCCAGTTGAAGTG
|
10140820ACGTTGGATGTTCCTATCACAGTTGAGGAGACGTTGGATGAGTCCTTTGCATTCTAGCAC
|
12431623ACGTTGGATGGACAATCCTAGGGACATCTCACGTTGGATGTCATCAGGCTTCAGGCTTTC
|
6574090ACGTTGGATGTTGCAGTAGGGTTTGTGCTCACGTTGGATGATCACTCGCATTACCACCTG
|
8008750ACGTTGGATGTTGGGTACTGTGGCTCTAAGACGTTGGATGAGCATGTGGGTAGGGAGATT
|
11627420ACGTTGGATGGTGAGCACTGAAGGAACAGGACGTTGGATGTGCACTCTCTGACACAGCAG
|
10150185ACGTTGGATGCTAGTTCTAGATCCCTGAGGACGTTGGATGAAAGCACTGCCCCTGTAAAC
|
10150218ACGTTGGATGGCACACAGAAGACGACTAAGACGTTGGATGGTTCCTGATGTATCACTGAG
|
9646164ACGTTGGATGCCTGATGTATCACTGAGTGGACGTTGGATGGCACACAGAAGACGACTAAG
|
6574091ACGTTGGATGAGCTTGAAGCGAAAAGCACGACGTTGGATGCAGGGAGAGTTAGATGACTC
|
2332912ACGTTGGATGTACACACCCTAAGCACCTACACGTTGGATGAAGGGAAGCAGTGTAGGAAG
|
7155359ACGTTGGATGCAAGCAAACTCTCTATCACCACGTTGGATGTTGCTCCAAGCTTCCTTTGC
|
2332913ACGTTGGATGAGCCACCCATTTTGCAAAGGACGTTGGATGATTTAACCCTTCCTGGAATG
|
4544184ACGTTGGATGCCCCTTTCTGGGTTTATGTGACGTTGGATGTTGGAGCAAGAACACACAGG
|
4337224ACGTTGGATGATTCCCTTCCAGGTCTACACACGTTGGATGTATGTCCGCTGCTCTTTGAG
|
2332914ACGTTGGATGGTGCTGCCAAAAGGCATCAGACGTTGGATGGTAACGTCTCCACCCCAAAG
|
4280167ACGTTGGATGTGACAGTAAGTATGGGCCGGACGTTGGATGAAGGAAGCACAGGGAAGAGG
|
4903049ACGTTGGATGGGCTTCAGTCCTTTGGTTTGACGTTGGATGTTGCTCACCTGTATCACCTC
|
3742837ACGTTGGATGAGTGAAGCTAGGAGGCTAAGACGTTGGATGAGCTGTACTGAAAAGCCCTC
|
10139937ACGTTGGATGAGCCCTCCTCTACCAAATTCACGTTGGATGAGTGAAGCTAGGAGGCTAAG
|
12434292ACGTTGGATGTGCTCCTTAGCCTCCTAGCTACGTTGGATGTACGTGCATCAGCTGGTCTG
|
11620671ACGTTGGATGTCAGGACTGTCTGGCTCTTGACGTTGGATGTATCAGGAGCAAGGCCTGAC
|
10140184ACGTTGGATGAGACAGTCCTGACATCCAGGCACGTTGGATGTACTGAGTAGGCCAAGCATG
|
2332915ACGTTGGATGTCCTCAGCTTGTCTCTCTCCACGTTGGATGTCAACTCTGAGTAATGAGGG
|
2332916ACGTTGGATGACATGCAAGGGACTCTTCCTACGTTGGATGAGGCCAAGTAGGATTCTGAG
|
8012759ACGTTGGATGACTCAGAATCCTACTTGGCCACGTTGGATGAGGGTGTGAGTGGATGTAAG
|
10149272ACGTTGGATGGATGTGTTGAGTGCTTCCTGACGTTGGATGGCTGTTGAGAGAGTTTGAGC
|
11158973ACGTTGGATGTCCTTGAGGGCAAAAATGGCACGTTGGATGTGCAAAAGAGCTTTGCACGC
|
4903050ACGTTGGATGAGAGGAATGAAGTAGGGTGGACGTTGGATGGTCTCCAGGCTCTGTTATAG
|
10666445ACGTTGGATGAGGAAGAATGAAGGAGGGAGACGTTGGATGATGGCAGGGACTTAGCATTG
|
2536143ACGTTGGATGAAGACCCTTGACTAGGACAGACGTTGGATGTGGGCCACACTGTTTGAGAA
|
10638231ACGTTGGATGTGAGAACCACTGCTCTACACACGTTGGATGATGACAGAGTGACTCCGTCT
|
12431636ACGTTGGATGAGTGCAGTGGCTCAATCTCGACGTTGGATGCTGAGGCGGAGAATCACTTG
|
8005904ACGTTGGATGCCAGGATGGTCTCAATCTCCACGTTGGATGACGGTGGCTCACACCTGTAAT
|
11621058ACGTTGGATGTCCCAAGTAGCTGTAACCAGACGTTGGATGCAACATGGTGAGAACTCATC
|
10133224ACGTTGGATGAGGGCTAAGGTAGGGATTACACGTTGGATGAGTGGTAGAGCTGGAATTTG
|
12433185ACGTTGGATGTGCACTCACAGCCTCAGTTCACGTTGGATGGAGGCCCCCATCTCTAAAAC
|
740974ACGTTGGATGTGAAGAGGACCATTTCCCACACGTTGGATGAAAGAGCTGTGCATGTCCAG
|
740973ACGTTGGATGAAAGAGCTGTGCATGTCCAGACGTTGGATGAGGACCATTTCCCACACTTG
|
740972ACGTTGGATGAAGGAGACTTTCGAGCTTGGACGTTGGATGAAGGAAAGCAAGTGGGTCTG
|
740971ACGTTGGATGTTTGGGAGTTCACCAAAGGCACGTTGGATGAAACTGGCCTAGACCCATTC
|
4243642ACGTTGGATGTACAGAAGAGGTATGCTGTGACGTTGGATGTAGTCCCTTATCATTTCCCC
|
4415952ACGTTGGATGGCCTGGGAACTTGCTTCTAAACGTTGGATGAGGACCCCACTCAGAAATTC
|
2215589ACGTTGGATGTAAGTGCTTATCCGTGGGAGACGTTGGATGCTGGAAAATGGACTCTCAGG
|
4343211ACGTTGGATGAAGGGCATGTGACAATAACCACGTTGGATGCTGAGAGTCCATTTTCCAGG
|
2536142ACGTTGGATGTTTTTCCCCTCTGCCCTTCCACGTTGGATGTCTGGAGGCTTGAGACCATC
|
11293340ACGTTGGATGCTACCCCGGCAAACTTCTTTACGTTGGATGACCCGTACATTGTGCACATG
|
10151620ACGTTGGATGTCTGAACTCTTCCAGGCTACACGTTGGATGGGCCATGGTCTTACATGGAG
|
2286840ACGTTGGATGAACTCCAGACAGCATTTCAGACGTTGGATGAGGGAAAAACCATCAGAGAG
|
8023089ACGTTGGATGAAGAGACTATGCTGGTAGGGACGTTGGATGATTTCTGAGGTGGCCCTTTG
|
8008009ACGTTGGATGATCTGGAGCACTCAAAACTGACGTTGGATGCCAGTCACATTGCAACATAG
|
11419089ACGTTGGATGAAAGTGAGTCCCTGTCTCAGACGTTGGATGACAATGGGAGTAGGAAAAGA
|
10694676ACGTTGGATGAAAGTGAGTCCCTGTCTCAGACGTTGGATGACAATGGGAGTAGGAAAAGA
|
2536141ACGTTGGATGTGAGGTGGGAGGATCGCTTAACGTTGGATGACAGGGACTCACTTTATTGC
|
765247ACGTTGGATGGAAGAGATGATGACTTGCCCACGTTGGATGATGCAGATGAGCTACCACAC
|
7147626ACGTTGGATGTTTGCAGCTTGCCTAGCATGACGTTGGATGCTTCATCCTTCAGTTTCCCC
|
10132629ACGTTGGATGTTTGCAGCTTGCCTAGCATGACGTTGGATGCTTCATCCTTCAGTTTCCCC
|
4903051ACGTTGGATGGTCTAGGAAAGGGAGAACAGACGTTGGATGAAAACTCCCTCCTAACACCC
|
11158974ACGTTGGATGTTTGTAGTTGGACACCCCACACGTTGGATGAGCTTGTTTCAGACCTCAGG
|
1035021ACGTTGGATGCATGGAGAGGAGATTGGATGACGTTGGATGATCTCTGGCCTGGAATACTG
|
6574093ACGTTGGATGACATACCCAGAGCATCAAGGACGTTGGATGCAAGGTCTGTCATCTCTGTG
|
4899439ACGTTGGATGAGAATCTCCTTCTGTTCCTCACGTTGGATGATGAAGAAGGTGAGGGTGAG
|
7155287ACGTTGGATGAGTGTACATCCGGGGAAATGACGTTGGATGGAATCTCCTTCTGTTCCTCC
|
7154402ACGTTGGATGGCCATGAAAAGACATGAAGGACGTTGGATGCCAGGATGTCATATACTTGG
|
7154781ACGTTGGATGGTTCAAAGTCTGCATGACGGACGTTGGATGGTGGACAGATGCCATTACAC
|
6574094ACGTTGGATGATGGTGACAGGAACACTCTGACGTTGGATGAGAAGAAGGTGGATGCCAGG
|
10132242ACGTTGGATGTTGTCCGATGTCATGGCTGGACGTTGGATGAGCTGAGCCAGAGCAGAAAG
|
10146959ACGTTGGATGTGAACTAGCTTTTCATGGAGACGTTGGATGTATCCCAGCTCTTGTCTGTC
|
10147466ACGTTGGATGGGTGATAAAGTAAGACCCTGACGTTGGATGTGACAGAGGGTTGGTGTGTT
|
11626411ACGTTGGATGTTGTTTCTTCCCTTGGTTCCACGTTGGATGAAGAACCTGGAGATAGCACC
|
4899440ACGTTGGATGTACCTGCACTTTCCACTTCCACGTTGGATGTTTAATGGATGCCCGCTTGC
|
10144553ACGTTGGATGGTCTCTTTGGACTGTAAGCCACGTTGGATGTAGGGACATAGGAGGTGAAC
|
11627663ACGTTGGATGTCAGCTGCATTCTCATCCTGACGTTGGATGTTTTGTAGATGCGTCACCCG
|
11627799ACGTTGGATGTGGTCCTTCCTTGAAAAGTCACGTTGGATGTCCTCAGTTAAAGATCTGCC
|
11851733ACGTTGGATGTCTGAAGGCAGAACCTATGGACGTTGGATGGGTCACAGAGACATGTAGTG
|
10140317ACGTTGGATGCCAGACTTTGAAGACAATGCACGTTGGATGAAGGAAGAAAGTCAGGTGTC
|
8007375ACGTTGGATGCCCTTGCACAATGTATGTCCACGTTGGATGATCCTATATCCAGATGGGCC
|
4899441ACGTTGGATGAATTAGAAGTAGAGGCAGAGACGTTGGATGGGATATAAACCCATGGATCG
|
11158975ACGTTGGATGAAGCCATTGCTCTTTGCTGGACGTTGGATGAACCTCCGAGACAAACAAGG
|
11419607ACGTTGGATGAAGCCATTGCTCTTTGCTGGACGTTGGATGAACCTCCGAGACAAACAAGG
|
2109793ACGTTGGATGGCATGATCTTGGCTCACTGCACGTTGGATGTAGTCCCAGTGACTCGAGAG
|
8023156ACGTTGGATGCAAGGAGAGGGAAACTGTAGACGTTGGATGTATGAAGTGTCTGGCACAGG
|
10140579ACGTTGGATGAAGCAGGGTATCTTCCACTGACGTTGGATGTGGCCATTGCTCCTGGAGCTT
|
7148199ACGTTGGATGTGGGTCTCTGCAACACAGTTACGTTGGATGATGGCACACACTTTTCCAGC
|
7146916ACGTTGGATGATTCTACCTCCACACTGCACACGTTGGATGGAGCTGTCTGCAGCAAATTC
|
1990439ACGTTGGATGAGAGCTGAAGTCACACAGACACGTTGGATGTATTACGTGCTGGAAGGGAC
|
6574095ACGTTGGATGTGACCTGGTTTCCTGACACAACGTTGGATGTTTCAGCAACGAAGTCCAGG
|
10140037ACGTTGGATGAAAAGACAGGCATCCTCAGGACGTTGGATGGGCTGAGTTATGTTGGAAAG
|
8007249ACGTTGGATGTAGGTCAAAGAGCATGTGTGACGTTGGATGGGAGAGGCTCTTTTTTACAC
|
1990438ACGTTGGATGCCTCTTTGGGTAAACAGACCACGTTGGATGTGGGAAATGACAAGCATCTG
|
1990437ACGTTGGATGCCCTAGGTTCTTCCTTTCCCACGTTGGATGTGAGTTCACAGCCTGCTTTG
|
10146484ACGTTGGATGATGGGCTCCTCAGATACATGACGTTGGATGGCCCATTTTAGAGGTGAGAG
|
11627333ACGTTGGATGGAGCCCATTTTAGAGGTGAGACGTTGGATGTCCTCAGATACATGAGCAGC
|
7155802ACGTTGGATGAGGAAGGACAGATTAGCTGGACGTTGGATGATTAACCAGAGTGTCCCATC
|
2109792ACGTTGGATGTATGTTGCCCAGCCTGGTTGACGTTGGATGATCCCAGCATTTTGGGAGGC
|
11429363ACGTTGGATGGCCAAACCATATCACCTAGCACGTTGGATGAACCAGGCTGGGCAACATAG
|
8004210ACGTTGGATGTTCTGTTATGTGCAGCCTAGACGTTGGATGTCTATGTTGGCCCCTTTCAG
|
2098194ACGTTGGATGTTCTGAAATCTAGGCAGAGGACGTTGGATGCTCAAGCCTTGACAAATTCC
|
2109791ACGTTGGATGTTCTGGGATCTGGAAGATGGACGTTGGATGAGTGTGAAAGGGAAATGTCG
|
11381729ACGTTGGATGTAGTGAGGGCTACATGTCTCACGTTGGATGGACAGAGTGAGACCCTGTTT
|
1160094ACGTTGGATGCAGAGAATCTAGGTTGCCTGACGTTGGATGGAGAAGAAGCCTGGCTAAAG
|
11628051ACGTTGGATGAGGTAATCAGTGGTAGCAGGACGTTGGATGGAGGAGGGAAAGTCAGATAG
|
10136771ACGTTGGATGAAGCACTCCTTCCACCTTGGACGTTGGATGTAGTGAGACCCTGTCTCTAC
|
10139903ACGTTGGATGATTGCAGACTGTCAAGCCTGACGTTGGATGAGAGCAGAGTCAGCCTAAGG
|
4903053ACGTTGGATGATTGCACAACTGCACTCCAGACGTTGGATGGGAATTGGTGGCGTTATGTC
|
3742836ACGTTGGATGAGCCGCAGTTTTGGATCTTCACGTTGGATGCCAGCTGTATACATACCCTG
|
3742835ACGTTGGATGAAAGATTAAAGGCTCCAGGCACGTTGGATGTTCAGCTTCCTCTCCTTGTG
|
8003233ACGTTGGATGAAAAATAGGCAGGAGGCCAGACGTTGGATGTGACAGTGATGCTGTTGGTG
|
11621588ACGTTGGATGACCCCCCATAATAAACCAGCACGTTGGATGGGGCTTCTGACAAGAACAAG
|
740981ACGTTGGATGGGAGGCAGATAACTCAAAGCACGTTGGATGTTCCCCACCTCCATCTACCA
|
8019492ACGTTGGATGTCCAGCCTATATGACAGAGCACGTTGGATGCTCTTTCCCTCTCCCTTTCT
|
8019644ACGTTGGATGCTCTTTCCCTCTCCCTTTCTACGTTGGATGTGACAGAGCAAGATTCTGTG
|
8019646ACGTTGGATGCTCTTTCCCTCTCCCTTTCTACGTTGGATGTGACAGAGCAAGATTCTGTG
|
8019653ACGTTGGATGTGACAGAGCAAGATTCTGTGACGTTGGATGCTCTTTCCCTCTCCCTTTCT
|
11450794ACGTTGGATGTGACAGAGCAAGATTCTGTGACGTTGGATGCTCTTTCCCTCTCCCTTTCT
|
11348193ACGTTGGATGCTCTTTCCCTCTCCCTTTCTACGTTGGATGTGACAGAGCAAGATTCTGTG
|
11450793ACGTTGGATGCTCTTTCCCTCTCCCTTTCTACGTTGGATGTGACAGAGCAAGATTCTGTG
|
11282735ACGTTGGATGCTCTTTCCCTCTCCCTTTCTACGTTGGATGTGACAGAGCAAGATTCTGTG
|
2191823ACGTTGGATGGGCACCCAACCCAAAATTACACGTTGGATGCAGTTTCAGTTCTGGGTTGG
|
12232220ACGTTGGATGCAGCATCAGAAATGGTCTAGACGTTGGATGCCAAATTGTTGGGATTACAGG
|
11158976ACGTTGGATGCCATCTGCAAGAAAATAAACACGTTGGATGGGTTTCACATTTAGGTCTATG
|
4903054ACGTTGGATGGCTGTTTCAGATACATGTCCACGTTGGATGGCGACATTCCGCCTCAAAAA
|
11846755ACGTTGGATGTGTGAGATATCGTCAGATTCACGTTGGATGTCAGAAGCACAGCTGACAAC
|
12431988ACGTTGGATGGGTCTCCTTTCAAGCTATGCACGTTGGATGGGATGTCAACAGAAGCCAAG
|
12100526ACGTTGGATGGCTTTGACTGAATCTTGGAGACGTTGGATGATAGCTTGAAAGGAGACCTG
|
11622568ACGTTGGATGTCAGCTTCTTCAACCTGTGGACGTTGGATGAGAGGGTTGAACTGAAGAAG
|
9671230ACGTTGGATGAGCTGATTTCAGTCCTGGAGACGTTGGATGCTTCTTGCCATCCTAATATT
|
12147487ACGTTGGATGACCCCAGTAGTTTCTGATGGACGTTGGATGAATAGCTGATTTCAGTCCTG
|
4903055ACGTTGGATGAAGCGATTCTCCTGCCTCAGACGTTGGATGTGGTGAAACCCCATCTCTGC
|
12147515ACGTTGGATGTGGAGTGCAGTGGCATGATCACGTTGGATGTGAGGCAGGAGAATCGCTTG
|
11625092ACGTTGGATGATCCTGAATGGCCAGAGATGACGTTGGATGATACCACCAGGAACTCACAG
|
4899442ACGTTGGATGCTACCACTCAGGAGTTGTTCACGTTGGATGATTTGGTTGCGTTCCCATGG
|
2052146ACGTTGGATGTTATTTGAGCTCTGATAGTGACGTTGGATGCCACAAAAGCACGTGATTTC
|
10220553ACGTTGGATGATTTTTCTGGCTCTGCCTGGACGTTGGATGTGTTGAAGCAGGGCTACATG
|
10220565ACGTTGGATGACAAAAACTAGCTGGGTGTGACGTTGGATGCCGGGTTCAAGTGATTCTCA
|
2332917ACGTTGGATGACCCCAGTAAGAGGCTTGAAACGTTGGATGGCACAGGTTAATAAATGCCTC
|
7158910ACGTTGGATGCCTACTTCTTCTTCCCACACACGTTGGATGGCCAGGTAAATTCAAGCCTC
|
8015749ACGTTGGATGGACTGGCTTATTTGACTTAGCACGTTGGATGGGAAGGAAATTCTGACATATG
|
8006812ACGTTGGATGACATGACATTCAACAGCCCCACGTTGGATGTTCCGAATCTCTGCCAACAC
|
8008338ACGTTGGATGTTAAACAGACCAGGTGTTGGACGTTGGATGATCAGGGAGGATGAAATCTC
|
2052145ACGTTGGATGGGCTTCTCAATTCAGATGGGACGTTGGATGGTGCTGGCTGCCTAGTTCTA
|
2052144ACGTTGGATGGGGTTGCTGGAAATCTCATGACGTTGGATGGGTACTTCTGTGATCCCATC
|
10146692ACGTTGGATGTAAGCAGAGCTGAAGAGAAGACGTTGGATGGAGACAGCAGGAAAACTTGG
|
11627305ACGTTGGATGAAGTTTTCCTGCTGTCTCACACGTTGGATGGCAGGAAGTTAGCATATTGG
|
2079989ACGTTGGATGATCATGGCAGAAGGCAAAGGACGTTGGATGAAAAGTGTATGGTGCCTCCC
|
8018881ACGTTGGATGAGAATGGCCTAATCCAGGAGACGTTGGATGTGTCTCTGCCTTATATGGGC
|
4561387ACGTTGGATGCCCTCATGGAGTTTATAGTCACGTTGGATGCCCCTTTCCTTCCACATTTT
|
11622025ACGTTGGATGAGCAAGTACTGCACTTTGGGACGTTGGATGTAAGCTAGAACCTCTGGCAC
|
740980ACGTTGGATGATGCCTGCCACATTGGGTAAACGTTGGATGGGTAGGGCTGTCTGTTTCAT
|
12433250ACGTTGGATGTGCAGGGTAGCATGAATTTGACGTTGGATGTATCCTCCAAGTTCAAATCC
|
5809590ACGTTGGATGATAGGTCTGATGTCAGCAGCACGTTGGATGGTGCCACAGAACTGACATTC
|
758915ACGTTGGATGCAATGCTGCTGACATCAGACACGTTGGATGCAAGAAGGGCATTTCTACCC
|
758914ACGTTGGATGTGTGATCCAGACATCAGCTCACGTTGGATGCCCTTGTTTTAGAGGTTGGG
|
7154229ACGTTGGATGCCCACAGAAACAAAACCAGCACGTTGGATGAGCCACCATGTTTGAATGGC
|
12437188ACGTTGGATGCGGACATAACTTTCCCAAGGACGTTGGATGGTGGCTCTGACCTTCAAAAC
|
7159108ACGTTGGATGCACATCTCGAGGTTGAAGTCACGTTGGATGACTGGAAGGAATCACACTGC
|
4903058ACGTTGGATGCCCTAGATAAAGCAGGCTTCACGTTGGATGTAAATCTCTCCTCTGGAGGC
|
4899443ACGTTGGATGATTGCAGTGGTGCAGTGGAGACGTTGGATGTAGTCCCAGCTACTCTGGAG
|
11848907ACGTTGGATGAAGACAGAGGTTGCAGTGAGACGTTGGATGTGCCATGGCCTGATTTCCAC
|
12432148ACGTTGGATGGAAGACATTGGAGGTGTTAGACGTTGGATGAGCGAGACTCCATCTCAAAG
|
12435078ACGTTGGATGCTAAGGGTATCTCACCTCAGACGTTGGATGCAAGAAGATCTGGGAGAAGC
|
6574096ACGTTGGATGTGGCACATAGGAAATGCTCGACGTTGGATGTTCAAGCTGTCAGTTGCAGG
|
11158977ACGTTGGATGTAGAAGGCTGGAAGTCAGTGACGTTGGATGTGTTGTGTTGGGCAGAAAGG
|
11629434ACGTTGGATGTCAGGACCACAAATCCCATGACGTTGGATGATGGGAACTGAAGGTCATCC
|
4378563ACGTTGGATGTTATGGCTTCCTCTCCCTACACGTTGGATGCGTGTGCATATCCTGATCAC
|
2098195ACGTTGGATGCAAAGTTCTCTGCCTGAGTGACGTTGGATGGCTCCAGTCTCTAATCACAC
|
4633653ACGTTGGATGAACTGCCTGGCCATGCTAAGACGTTGGATGTTACCAAGTGCATGCCCGTC
|
7148350ACGTTGGATGACCCCTTTGTTGGCCTTTACACGTTGGATGCTTTCTTTGCCTCTCCAGTC
|
740979ACGTTGGATGAAGGGCCAAGCAATGCTTTGACGTTGGATGATCCTAACCAGGTCTGATGG
|
740978ACGTTGGATGCTTCACATCCCTCCTCAAAGACGTTGGATGTAGCCACGCCATTATTGGAG
|
740977ACGTTGGATGCAGCAACCCAAAGCAACACGACGTTGGATGTCCAGTGAGGCCTCCCTCCAA
|
740976ACGTTGGATGATCAGGACTACCTGAGCAACACGTTGGATGTCCTGTTTCTAAGCAGGGAG
|
4903059ACGTTGGATGGGTGGTCTTGTTTCAGAGTCACGTTGGATGCGAATCAGTCAGCAAACCTC
|
4903060ACGTTGGATGAGAATCTGGAGGGACCAATGACGTTGGATGAATGTCCCCAGCCTTACTTC
|
11852056ACGTTGGATGAATGTCCCCAGCCTTACTTCACGTTGGATGAGAATCTGGAGGGACCAATG
|
9635257ACGTTGGATGTGAGTGCTACATGGCCTCTGACGTTGGATGTTGGAGACAGAGAACAAACC
|
9635258ACGTTGGATGTTCTTTGCTGCCAGGGTTTGACGTTGGATGGCAAACCTTCAAGCCAGCAA
|
9635259ACGTTGGATGTCCTGGTGCCTCAAACAAAGACGTTGGATGACCTGCCACATAGTAGTTGC
|
4899444ACGTTGGATGCCAGTTCATCCACTTAGTAGACGTTGGATGCTGGGTTGCCATTTGCATAC
|
12435382ACGTTGGATGTCTGTCAATGTCTCTCTCTCACGTTGGATGAACATCCATCCTGAATCACC
|
12435412ACGTTGGATGTATTAGGCTCCCACATCTGGACGTTGGATGCCCTTGCATAGATGATGCTG
|
11627381ACGTTGGATGTTTTTCTGGCACTGGTGGTGACGTTGGATGACCTCACTATGGGTGATCAG
|
2052143ACGTTGGATGTGTGTCACTTCTACCTCCACACGTTGGATGCCAGTGTAATCACAAGGGTC
|
2052142ACGTTGGATGACTGGACTCACCCACATAAGACGTTGGATGGGTATGAGGGATTTTGCAGG
|
2052141ACGTTGGATGATAGAAGCGTGACCTTACCCACGTTGGATGCCTGCAAAATCCCTCATACC
|
8021035ACGTTGGATGATGTACAAACTGAGGCTAGGACGTTGGATGCTTCACCTGAGAGATTTCAG
|
11158978ACGTTGGATGTTAGCCAGGCATAGTGGCATACGTTGGATGTTATTGTAACCTCCGCCTCC
|
11621216ACGTTGGATGAGCTTGCATTTACCACTCACACGTTGGATGTAGAAAGTAGACCTCTTGGG
|
10130873ACGTTGGATGGGCTTGGCATTTCTTGTCACACGTTGGATGTAGAGAAAAGGAGGAAGGAG
|
11621358ACGTTGGATGGGCTTGGCATTTCTTGTCACACGTTGGATGTAGAGAAAAGGAGGAAGGAG
|
758913ACGTTGGATGAGCAACCAGTCTAGTTTTCGACGTTGGATGCCTAGCCAACATCCTTTTCC
|
11622602ACGTTGGATGCCTAGCCAACATCCTTTTCCACGTTGGATGGGATCTCTAAGCAACCAGTC
|
10136931ACGTTGGATGTATTCTGTATCCCAGTAGCCACGTTGGATGCCATTTCCTATCTTGGTTTC
|
740975ACGTTGGATGCTCAGTGCCAGAAATACCAGACGTTGGATGGAAACCAAGATAGGAAATGG
|
747987ACGTTGGATGCCTTGTGAACTTCCAACCTGACGTTGGATGAGGTCTGGCACTGCTAAATG
|
11623819ACGTTGGATGTCATCTTGGCAACTCCTTCCACGTTGGATGAGTAAGCCCTGATATGCCTG
|
12434445ACGTTGGATGCTCTTAGTATGGAAAGGCAGACGTTGGATGTTGGCATCCTTTGTAAACAG
|
8003375ACGTTGGATGTAAGGATGGTTCACTGTGGCACGTTGGATGAGCTGCCATCTGTAGCATTC
|
10143596ACGTTGGATGTACCATCCCTTATTAGATGGACGTTGGATGACATCCATCTGTGCATCCAT
|
12435321ACGTTGGATGTCCTATATTGTCAGATGGCCACGTTGGATGCCTACACACAAATAGGCATG
|
12435401ACGTTGGATGGTATGGTTTTGGGTGTCTGGACGTTGGATGTAACCACTGTGGCTTGAGAG
|
8010609ACGTTGGATGTCTTCTGTTTCTGTGGCTGCACGTTGGATGAAAAGCTGGCCCTAAAAGGC
|
11158979ACGTTGGATGATGTCCAGACACCAAAACCCACGTTGGATGATCTACTTGGATCTGGGCAG
|
11158980ACGTTGGATGAACCACACTGTGCACTCTTCACGTTGGATGGGGCATGAACGATATGCAGT
|
11627524ACGTTGGATGCGACAGATCAGGAAAATAGCACGTTGGATGGTGTTCAGGACAGCATATCC
|
1126160ACGTTGGATGTGTTCTCACCCTGTTCTGTTACGTTGGATGGGGTTCTCTCTTGACAGATG
|
10136074ACGTTGGATGTTGTCCATGTGACCTCTATGACGTTGGATGGGGCCATGAAAACCTAGTTC
|
4903061ACGTTGGATGCATAGAGCCCTCAAAGGTAGACGTTGGATGAGGAGTAGTGAGAAGGAATC
|
10665398ACGTTGGATGGGGCTGCACCTTGTATTTAGACGTTGGATGTACTGTGTAAAACGAGGGAG
|
6574097ACGTTGGATGGGGCTGCACCTTGTATTTAGACGTTGGATGTACTGTGTAAAACGAGGGAG
|
9671654ACGTTGGATGTACTGTGTAAAACGAGGGAGACGTTGGATGGGGCTGCACCTTGTATTTAG
|
10140024ACGTTGGATGCCTGCAGCTTCTAAAACTGCACGTTGGATGTCCCAAAGTGCTGGGATTAC
|
10142421ACGTTGGATGTGATCTCAGATCACCGCAACACGTTGGATGTGTAATCCCAGCTACTCAGG
|
10142593ACGTTGGATGATCTGAGATCACGCCATTGCACGTTGGATGGGTTTGGGCTTCCATGCAGT
|
11423372ACGTTGGATGCCCATCCTACTTTTCACACCACGTTGGATGAGTTGAGATTGTGCCACTGC
|
5809592ACGTTGGATGCCCATCCTACTTTTCACACCACGTTGGATGTGCAGTGAGTTGAGATTGTG
|
2332918ACGTTGGATGTAGGATGGGTGTTTCCTAGCACGTTGGATGAACCCATGGGACCACAATTC
|
2332919ACGTTGGATGATGAAGGAAGAAGCCCTGACACGTTGGATGTCTGAGGGCTCTCTCTAATG
|
8007348ACGTTGGATGTGAAGGGAAAGGAGGCCAAGACGTTGGATGTCTTCTGGGATCCAGTCAGG
|
1990443ACGTTGGATGTACATGATCCTCCCCTCTACACGTTGGATGCACTGGATTTGGCAAGAAGG
|
8007690ACGTTGGATGTCAGCTCTTAGCCATCCTTCACGTTGGATGGCCACTGGATTTGGCAAGAA
|
3937455ACGTTGGATGACCTCCACACTCATTACCTCACGTTGGATGGCAAGAATAGGTTCTTTCGC
|
8012823ACGTTGGATGTTGTCGGTCTCTTCTAAGTGACGTTGGATGGCACCGAGTAATATGGAGTC
|
4899445ACGTTGGATGAAGGTGAGAGAAAACTCACCACGTTGGATGCAGGAGAGTCTGCCCATTTG
|
4903062ACGTTGGATGATGTCTTACTTATGCCCTTGACGTTGGATGTCCTAAGAAATAGGTGCTTC
|
973963ACGTTGGATGACAAACCACTAAACTTTCAGACGTTGGATGGATTTGTTCTGGCAGGAATG
|
10149962ACGTTGGATGAAATGGAGTAAGGGTCAGGGACGTTGGATGGGGAGCTGGTGGTGAAAAAT
|
8003449ACGTTGGATGTCCAGGCCAACATTTTCAGGACGTTGGATGTTTGTGCTACTGGAGGGAAG
|
11620775ACGTTGGATGAAACCAGCTTGTTGCTTCCCACGTTGGATGAGAAGAAGCTGTTCAGACCC
|
8009089ACGTTGGATGACACAGACAGACACTCCCACACGTTGGATGACTTCTCACTCTTTCTGGTAA
|
8008967ACGTTGGATGTGACCTGCCGACTTCTCACTACGTTGGATGTCCATCATCTAGGACCTTGG
|
12050132ACGTTGGATGTGCAGGGTTCTGAAAGGAAGACGTTGGATGTTATGTGCAGGCATGATGGC
|
10133018ACGTTGGATGGTGCTAAGTGCTTTCCATCCACGTTGGATGACTGCCCATCTGAGAAATGG
|
1990442ACGTTGGATGCCATCCCTCCAACTCAGAACACGTTGGATGTAGGTGTGCTCCCATTTAGC
|
1990441ACGTTGGATGCACACCCTGGCATGAATGTGACGTTGGATGTCAGAGATATGCACTGCAAG
|
8015833ACGTTGGATGTCAGAGATATGCACTGCAAGACGTTGGATGCACACCCTGGCATGAATGTG
|
1990440ACGTTGGATGCCAGGGTGTGTTCTAATACGACGTTGGATGAAGTCACTAACCCCACACAC
|
4903063ACGTTGGATGCCATCTCACATTGAGATGGGACGTTGGATGCCACCAACTCTCCAAAACTC
|
10139810ACGTTGGATGGCTTACCTTTTTCCCATCCCACGTTGGATGCAATGCTGTTACCAGGAACC
|
4903064ACGTTGGATGCTGCTCTGTGTCAGCAGAAAACGTTGGATGATGGAGGCTTTGTAGCTAGG
|
2159715ACGTTGGATGTACAGGCACTGGCGAAGAAGACGTTGGATGCTGCCTGCAAGTTCCCATTG
|
2109795ACGTTGGATGTCCTGACTCTCTCAAAACCCACGTTGGATGCAAACAAGGTCCCAGCATTC
|
2159714ACGTTGGATGAAAGCCCCTCTAGCAAAAGGACGTTGGATGAAACTCTCTCGTTGCTGTGG
|
11623107ACGTTGGATGTAAAGGTTAAGTGCCCTGCCACGTTGGATGAGTGAGAGATAGTGTTGCAG
|
7152005ACGTTGGATGACTAGGCTCCCCTGCTCACTAACGTTGGATGACCAACTCTGTAAGAGCAGC
|
7152489ACGTTGGATGATGAGATGATGGATGCTGGGACGTTGGATGTCCCACACTGATTATGGTGC
|
4479167ACGTTGGATGGATTACAGGTGTCAGCAACCACGTTGGATGGCCAGAATTACCCTGATACC
|
4606655ACGTTGGATGTTCCCGGTTAAGCAGTTCTCACGTTGGATGGTGAAACCCCGTCTCTACTA
|
4606656ACGTTGGATGTCACTGCAACATCTGCCTTCACGTTGGATGTTAGCTGGTCATGATGGCAG
|
4489943ACGTTGGATGAAGGCAGATGTTGCAGTGAGACGTTGGATGTTAGCTCTACGATCCATGTC
|
7142642ACGTTGGATGCCTCCAGAACTGTAAGACAGACGTTGGATGAAACGCATGGTATCAGTTCC
|
8006233ACGTTGGATGTTCCATATTTCCAGGGTGTGACGTTGGATGGACCTTGGGTAAGATATTGG
|
8007559ACGTTGGATGGACCGTGGATAGTCATCTCCACGTTGGATGCACAGGCTTAGCTGCTGGTG
|
8006156ACGTTGGATGTCTCCACCTTGTCTCAGAGCACGTTGGATGTGCCTGGCTCCACAGGCTTA
|
1468662ACGTTGGATGTCATGTAGGTTGGCTCTGACACGTTGGATGGCTAGAAATCACCAGCAACC
|
11627048ACGTTGGATGACAAGCTGGAGAGCTTCACTACGTTGGATGAAAAGCACCACTCCAATCAC
|
6574098ACGTTGGATGAACCTCTGACCTCAGGTGATACGTTGGATGAATTGTGGTTAATGGCTGGG
|
12433760ACGTTGGATGACTTTGGGAGGCCAAGGTGACGTTGGATGATGTTGGCCAGGCTGGTTTC
|
12433780ACGTTGGATGTTGAGGTCACGGGTTTGAAAACGTTGGATGCCACCATGCCCAGCTAATTT
|
12434506ACGTTGGATGAGCCTGGGAAACACAGAAAGACGTTGGATGACTGTAACCTCGAACTCGTG
|
12434673ACGTTGGATGAGCAGGTGACATTACCAGTCACGTTGGATGGTCATTAGGGAAATGCCCAC
|
12431400ACGTTGGATGAGCAGGTGACATTACCAGTCACGTTGGATGGTCATTAGGGAAATGCCCAC
|
12431384ACGTTGGATGGGTTGCACCATTGCATATTCACGTTGGATGTAATGTCACCTGCTGGTGAG
|
4903067ACGTTGGATGCTGCATTGGTATCAGGACTGACGTTGGATGCTAGCTTATTTCACTCGGCC
|
2332920ACGTTGGATGTACATATCACCACACCTGGCACGTTGGATGTGAGCCCAGGAGTTCAAGAC
|
2215591ACGTTGGATGTCCCCAGTTTGCATCTTGACACGTTGGATGATTTGTTAAAATTCATAGAAC
|
12433064ACGTTGGATGTGACTTGAGACCAGGAGTTCACGTTGGATGACATATGTGCCACCACACTC
|
12436263ACGTTGGATGAGTTCAAGACCAGCCTGGACACGTTGGATGATATGTGCCACCACACTCGG
|
12433097ACGTTGGATGTGATCACAGCTCACTGCAACACGTTGGATGTGTGGTGGCACATATGTTTG
|
12433184ACGTTGGATGTCCCAAGTAGTGTGCATGCCACGTTGGATGTGTGATCACGCCACTGTACT
|
8015900ACGTTGGATGTGGAGTGCAGTAGTGTGACCACGTTGGATGACACTACTTGGGAGGCTGAG
|
11296981ACGTTGGATGGAGTGAGATGTGTAGATGACACGTTGGATGGCCTAATTTCACCTCTCTTG
|
11344025ACGTTGGATGGAGTGAGATGTGTAGATGACACGTTGGATGGCCTAATTTCACCTCTCTTG
|
11464204ACGTTGGATGTAACATGGCGAGAGCTCATCACGTTGGATGAGCTAGGACTACAGGTACAC
|
11441172ACGTTGGATGTACAGGTACACACGACAGTGACGTTGGATGACTAGACTGAGTAACATGGC
|
11381807ACGTTGGATGACTAGACTGAGTAACATGGCACGTTGGATGTACAGGTACACACGACAGTG
|
10873251ACGTTGGATGATCTCAGGTGATCCACCCACACGTTGGATGTGGGCGCAGTGGCTTGTAAT
|
2109794ACGTTGGATGGCATCTGTTAAAAACAGGCCACGTTGGATGACTCCTGATCTCAGGTGATC
|
10873252ACGTTGGATGACTGGCTTCCAGGTTCAAGTACGTTGGATGTGGTGAAACCCCATCTCTAC
|
4520784ACGTTGGATGAATCTTGGCTCACCACAACCACGTTGGATGATGCCTGTAATCCCAGCTAC
|
2877820ACGTTGGATGTAGTAGCATTCCAAGTGCCCACGTTGGATGATAATCTATGTCCTAGATTG
|
2877821ACGTTGGATGTAGTAGCATTCCAAGTGCCCACGTTGGATGATAATCTATGTCCTAGATTG
|
4569195ACGTTGGATGGGAATGCTACTATTTGAAGGGACGTTGGATGTCTGTATCTTTCTGGTGATG
|
11628905ACGTTGGATGAGTTACATTCCAGGGAGTGGACGTTGGATGCCAAGACATTTCTGCACTCG
|
2191822ACGTTGGATGTGCAAAGTGGTGGAGGAAAGACGTTGGATGATTTTTCCCGGCATCTGACC
|
2191821ACGTTGGATGTGAGATGGATCTGGAGCCACACGTTGGATGGAAAGTGTCCTTAGCTTGCC
|
11464689ACGTTGGATGTCGCTTCAACAAGTTGCTTGACGTTGGATGAGAGTGAGACTCTGTCTCAA
|
12431959ACGTTGGATGACTTTGGGAGGCTGAAGTAGACGTTGGATGCATCACCCCTGGCTAATTTT
|
4903068ACGTTGGATGATGTGAGTGCCTAATACCTGACGTTGGATGGCCCTGAATTGATACTGAAC
|
1544579ACGTTGGATGCCTTATCTCTCTAAGACATGCACGTTGGATGACCATTATCATCTTCCCAGG
|
7155879ACGTTGGATGCCTTGATGCATCATCTCTCCACGTTGGATGTTGCCTCTATCCTGATCTGG
|
12433603ACGTTGGATGTTGCCTCTATCCTGATCTGGACGTTGGATGCCTTGATGCATCATCTCTCC
|
11351432ACGTTGGATGCAAGAGCGAAACTCCATCTCACGTTGGATGGTGGTTTGCAGAGGCTATTG
|
11448438ACGTTGGATGCAATAGCCTCTGCAAACCACACGTTGGATGCGGAACATGGCACATGAAAG
|
4243643ACGTTGGATGAAAGCTCTTGGGCTCAAGTGACGTTGGATGAATACAGTGTGTGCCAGCTG
|
4140952ACGTTGGATGCTCATGTTCATGCTACAAGCACGTTGGATGAACAAATGGAGAAAGGAGGG
|
8005372ACGTTGGATGCTCAACAAACAGTGGTTGAGACGTTGGATGTTCTGCTATGTTGCATGACC
|
8004109ACGTTGGATGGGCAGGATCTGCTGTTTTTCACGTTGGATGGGTTGAGTACCTGCTATGTG
|
8008398ACGTTGGATGCCCATAGCTCTATGAACCTGACGTTGGATGATGTGCTAAGCACCATGCTG
|
8009692ACGTTGGATGTCTTCTCCTCTAGAAGATGCACGTTGGATGAAACAGCAGATCCTGCCTTC
|
2332921ACGTTGGATGACAGGTTCATAGAGCTATGGACGTTGGATGCTTGTCTCAATCTTCTCCTC
|
12050320ACGTTGGATGTGGGCCAGCAATCTATGCACACGTTGGATGTTTGCCCTTCATTGCTCCTC
|
12050323ACGTTGGATGAAGGGCAAAGGCTGAGAAAGACGTTGGATGTAAAGTCCAAACTCCTTGGC
|
8010316ACGTTGGATGCCTCATTCACATTGATCAGCACGTTGGATGCCATAGGACAAAAAGTGCAC
|
7154293ACGTTGGATGCGGATCACTTGAGATCAGGAACGTTGGATGTGCTACCACACCCAGCTAAC
|
12147969ACGTTGGATGTCTCCAATCCTGCTCATGGGACGTTGGATGTTGATACGGCTTCCACAGTG
|
2215590ACGTTGGATGATGAGAGCCTTTCTTCAGGGACGTTGGATGTCCAAGAAGGACAGCAGTAG
|
4265749ACGTTGGATGGGGAAGGAACTTGTTCAGGAACGTTGGATGGCCAAAACTGAAGCCTTGAG
|
1004552ACGTTGGATGGCAAAACCCAGTGCCAAAACACGTTGGATGGATCATCCAAGTATGCTCCC
|
4307892ACGTTGGATGGCAAGCCTTCTGAAAAGTTGACGTTGGATGAGGTAGGGAAAGAGGAAAAC
|
12431973ACGTTGGATGAGCTACTCAGTAGGCTGAAGACGTTGGATGTCATAGCTCATTGCAGCCTC
|
12431975ACGTTGGATGAGCTACTCAGTAGGCTGAAGACGTTGGATGCAGTAGTGCAATCATAGCTC
|
767874ACGTTGGATGAAGGTGATAAAGTCCCCTGGACGTTGGATGGTCACACCATGTATCCTCTG
|
11628597ACGTTGGATGAAAGCCACTTGTGTCTCCAGACGTTGGATGAGACCACATTCCCAGACATC
|
10129371ACGTTGGATGGGTGTTCTGCAGATCATATCACGTTGGATGTTTATTATCCAGGGTTGCCC
|
4903069ACGTTGGATGAATTGCTTGAACCTGGGAGGACGTTGGATGAAGGCAGAGTTTCCTTCTGT
|
4903070ACGTTGGATGTTTCACCATGTTGGCCAGACACGTTGGATGTAATCCCAGCACTTTGGGTG
|
4903071ACGTTGGATGGCATGACAAAGTGTGGGATCACGTTGGATGCACCTGGCCAGAATCACTTT
|
11622224ACGTTGGATGATGGCCAACTCCTTTCTTCTACGTTGGATGAAGATAAGCTGAGAGACCAG
|
10459455ACGTTGGATGTGGCTCGATCTCGACTCATGACGTTGGATGGGTGGTGCACACCTGTAATC
|
9323577ACGTTGGATGAGGTTGCCATGAGTCGAGATACGTTGGATGTCCAGGGTGCTGTTTTTTGG
|
10624648ACGTTGGATGTTCTGTTTTGCCCTCCCTTCACGTTGGATGTTATGAGGGAGCAGTGTGTG
|
3058953ACGTTGGATGTTCTGTTTTGCCCTCCCTTCACGTTGGATGTTATGAGGGAGCAGTGTGTG
|
11158981ACGTTGGATGAGTGAGACCCTGTCTCTAAGACGTTGGATGGGGTGCCAATTATCTGCTTG
|
11158982ACGTTGGATGCCAAAAACTACCACATGCTCACGTTGGATGCATCGCTATATAGTGCTCTG
|
11158983ACGTTGGATGATGCCCAGCTCACAATCATGACGTTGGATGTTGGGTGGTGAACATATGTG
|
1860750ACGTTGGATGGTCCGCTGGATTGCTTTATCACGTTGGATGCAGTGTGAGACTCCATCTCA
|
1860749ACGTTGGATGAACATGATTAAGGATAAAGCACGTTGGATGTCCCCGGAATGATACATGAC
|
1860748ACGTTGGATGAAAGCAATCCAGCGGACAAGACGTTGGATGACTCGACTAGCTAGTCTTGG
|
1860747ACGTTGGATGTTGGCATTGACAGAGGAGAGACGTTGGATGAAAGCAATCCAGCGGACAAG
|
11419679ACGTTGGATGTACTGAGCCCAGTAGTAAGGACGTTGGATGCTCCCTGTGTACCTCATTTC
|
8011777ACGTTGGATGTGGGCGACAGAGTGAGACTCACGTTGGATGCATGTTGGCCAGGCTAGTCT
|
6574099ACGTTGGATGAGTAGAGACGAGGTTTCACCACGTTGGATGAGGTGGGCAGATCACAAGGT
|
8010957ACGTTGGATGAAGTGCTGGGATTATGAGCCACGTTGGATGTGGGTGTGTCTCCAGTAAAG
|
11626895ACGTTGGATGGGGAAGAATAAGAGCCCATCACGTTGGATGCCAGCCAGTAGCAGAGTTTT
|
10151431ACGTTGGATGAAGTGCAATGGCGCGATCTCACGTTGGATGTACTTGGGAAGCTGAGGCAG
|
4903072ACGTTGGATGTCTGCTTCTCTTCCTGTGTGACGTTGGATGAAGCACAAAACGTGGTCCAG
|
4589489ACGTTGGATGAGGTGAAATGTGGACCACACACGTTGGATGGGCAGTTCTCCTAGCTAAAG
|
9671327ACGTTGGATGATTACAGGCATGAGCCACTGACGTTGGATGGGATTGCTTTCTGGTTGTGC
|
4899446ACGTTGGATGGGATTGCTTTCTGGTTGTGCACGTTGGATGGCCTCCCAAATTGCTGAGAT
|
10144501ACGTTGGATGAAGAATCGCTTGAACCCAGGACGTTGGATGATGGAGTTTCTCTCTGTCGC
|
5809594ACGTTGGATGCATGAGCGAGTTCACATGGGACGTTGGATGTGGACCTAAATACTGGTGGG
|
720317ACGTTGGATGTGGACCTAAATACTGGTGGGACGTTGGATGCATGAGCGAGTTCACATGGG
|
8014316ACGTTGGATGGTTCATTTCCCGGCATTCTCACGTTGGATGGACCTGTGCTGAGAAACAAG
|
11158984ACGTTGGATGGACATAGTTCTGACCTCACCACGTTGGATGTTATGAGGACCAGGTGCTAG
|
6420906ACGTTGGATGCCCGAGGGATGAGTATTTTGACGTTGGATGTAGGAGGGCGATTACCCACA
|
8004055ACGTTGGATGTTTTTCCTCCTCCCACAGACACGTTGGATGGGCACCAGAGTTAAGACAAC
|
12434800ACGTTGGATGCCACTATTTTTTCCCCACTCACGTTGGATGGCAGGCTAAAAACATTCCATG
|
4243644ACGTTGGATGGGGAGTTCTCTCAATTTACCACGTTGGATGGGCAGAATAGTTGTTGGTAG
|
4899447ACGTTGGATGCTATTCTGCCATAGCCTTGCACGTTGGATGTCTATGCCTCAGCAAGCATG
|
4903073ACGTTGGATGTGTTCCCCAAAGCTAAGGAGACGTTGGATGCTATTCTGCCATAGCCTTGC
|
11848634ACGTTGGATGTCACTGCTGCTCTTGACTAGACGTTGGATGGGACAGACAGAGAGAAAACC
|
4899448ACGTTGGATGTCACTGCTGCTCTTGACTAGACGTTGGATGGGACAGACAGAGAGAAAACC
|
10131564ACGTTGGATGTGGAGAGACCAAACTGAGAGACGTTGGATGCCCTGCTTAGTAAATAGGCG
|
10134150ACGTTGGATGGCATGGTCTGTAGAAGAAGCACGTTGGATGAGACACATTCTGGGAAGGTC
|
763388ACGTTGGATGTACAGGGATTGTGATGTGGGACGTTGGATGGGGTACTCTTAGCTGAGAAC
|
11845938ACGTTGGATGATTGGCTTGAGGCATGAGTGACGTTGGATGAGTTTCCTGACATTCCCTGC
|
11845946ACGTTGGATGTCCTCGGTAAGCAGTTGTTGACGTTGGATGCCACATCACAATCCCTGTAC
|
11845915ACGTTGGATGCCACAGTCATTCAACACTTGACGTTGGATGGGAATGTCAGGAAACTTAGG
|
10137463ACGTTGGATGATAGCCTGCGCAGGTGAAAAACGTTGGATGAGCCAACCCAAATCCAGAAG
|
6574100ACGTTGGATGACACCAAGAGCTGGAGTGATACGTTGGATGGTCTGTCAGGTCACTAATGG
|
7140344ACGTTGGATGTGGCACCTAGTACATGCTAGACGTTGGATGCAGAGTGAGACTCCATCTCA
|
10646889ACGTTGGATGAGAGTGGGTAAGTGCACAAGACGTTGGATGTGGGTGACAGAGTTAAGACT
|
7146287ACGTTGGATGGGTGTCCCTTCAGGTCTAAAACGTTGGATGCCATGCAAATGTCCACACAG
|
10605948ACGTTGGATGCTTCATTGGTTCTCTGCAGCACGTTGGATGCAACACGTGATTCCAGAAGG
|
5809595ACGTTGGATGGTGGGCTTACACCATTTCTGACGTTGGATGATACCACCCAACTACCCATC
|
1035099ACGTTGGATGTGGGGAGAACTTTGGTCAACACGTTGGATGAAAGGGTACCCAGACTTCAC
|
7159877ACGTTGGATGATCTTGGCTCACCACAAACCACGTTGGATGGCCTGTAATCTCAGCTACTC
|
7142579ACGTTGGATGTACTACATGTCACAGTTCTGACGTTGGATGCGCTCACTCTGTGTATGTAT
|
12431762ACGTTGGATGCAACTTAAGGAGAGCTAGGGACGTTGGATGTCCTCCACTGGATAACTTGC
|
12431764ACGTTGGATGGGGTGAGAAACATACTCAACACGTTGGATGGTATTGTATGTACTCACCGC
|
10647999ACGTTGGATGGCTGTTTTTCCAAATTCTTTCCACGTTGGATGTCCAAATCACCTTTCTTAGC
|
6574101ACGTTGGATGTAAGAATGGGAGCTCAGTGGACGTTGGATGACCTGGATGCAAACTGGTTG
|
6574102ACGTTGGATGGATGTGACAACAAGAGAGGCACGTTGGATGACAGTCCTCACCATCACAAC
|
1861162ACGTTGGATGACCCTCTTGCTTTCATTGGGACGTTGGATGCTCTATATAGGCATGTGGGC
|
12432972ACGTTGGATGAAAACAAAGTCCCTGCCTTCACGTTGGATGTTCTGCCACAGCATTTACAC
|
10146134ACGTTGGATGGCATTGCACAGTTCAGTTTCACGTTGGATGGTTGGCACTCAGTAATTAGC
|
10146616ACGTTGGATGTGACTCAATCTCCCTCTCTCACGTTGGATGTTCAGGATGGAAGTGTGAGG
|
10146769ACGTTGGATGACATCCAGGCAGTAGAATGGACGTTGGATGTGAGTGGATTCCCATGACTC
|
8018936ACGTTGGATGGTCAATTCAGTGGCAAGGACACGTTGGATGTAAGGAGCCCATCAATGCAG
|
10483849ACGTTGGATGTGTAAGACCCTTGAGGTAGCACGTTGGATGGCCCACTGGTACTCATTTTC
|
2160137ACGTTGGATGGAAGGAAGAAGGGCAAAGGGACGTTGGATGGTGATGGAGTTGGTGGGAG
|
2192595ACGTTGGATGTGCAATTGAGGAGACTAGGGACGTTGGATGTCCCACCAACTCCATCACTT
|
2192594ACGTTGGATGGGCCATGCAATCGGATTTTCACGTTGGATGTGTTGTTGCATATGCAGGGC
|
11271695ACGTTGGATGAAGAAGTGCCTTTCACCTCCACGTTGGATGACATACCCAAGACTGGGAAG
|
10747301ACGTTGGATGTGCCTTGCTGGATTTCAGACACGTTGGATGGGTATGCAATTCCAAGTGGG
|
12050363ACGTTGGATGTACCTCCACTTTGCAGGGTAACGTTGGATGTGGAAAAGCTGCAGAGACTC
|
12050368ACGTTGGATGATGGTAGATCCACTAGCAGCACGTTGGATGCTGCGTACTTTCACAGTCTG
|
12432949ACGTTGGATGAAACAAACAACCCCATCAACACGTTGGATGTTCATGTGTCTTTTGGCTGC
|
7401375ACGTTGGATGGAGATACCATCTCACACCAGACGTTGGATGTTTCTCCACATCCTCTCCAG
|
8019682ACGTTGGATGGCAAAGGTGACTCTTGTATGACGTTGGATGCTCAAGTTCAAAGTTTCACG
|
8021248ACGTTGGATGGGTTTATCAGGGGTTTCAGCACGTTGGATGTGGCAGGAAGTGAAAGACAC
|
11158985ACGTTGGATGGTTGAGATTTGGGTGAGGACACGTTGGATGCACCACCACACCCAGTTAAT
|
10483850ACGTTGGATGCATTTCTGGAAGGAAGTGGCACGTTGGATGTTATTCTGATGGTAGTGCTG
|
8010875ACGTTGGATGGGCCCAGGCTTATTTCTCATACGTTGGATGACACAGATCTGTTTGGCTGG
|
11626844ACGTTGGATGAAAGCTTACAGGCAGCAGAGACGTTGGATGTTAGCGCAGCTATTCACCAC
|
982972ACGTTGGATGCCTCCATGAATTGCACCTTGACGTTGGATGGGGACAAAGCCAGAATACTC
|
7161198ACGTTGGATGGAGAGATAGAGATACCAGCGACGTTGGATGTCTTCCAAAAAGCCCCCAAC
|
7160347ACGTTGGATGTAGCTGTGTGTGGGATTTCCACGTTGGATGGTGCTTTGCATCTTCTGGTC
|
8007139ACGTTGGATGGGTGAGACAGAGAGAGATTCACGTTGGATGAGGGACAGTAGCCACATATG
|
8014483ACGTTGGATGCTTCTAACAGTGAAACTGGGACGTTGGATGTCTCTTTGCCTCTTTCATGC
|
12437072ACGTTGGATGATCAGAGGTTCCAACGTCACACGTTGGATGATGAGCTGGGTAAGTGAAGG
|
8004767ACGTTGGATGTATATTCTCTCCCCTCCCACACGTTGGATGCGGCTTTTCCTAGGAAAACC
|
12588830ACGTTGGATGTAGCACTTACTTTGCCCTGCACGTTGGATGGCTTCCACTCCAATAGAGAC
|
7158449ACGTTGGATGTATTTTTTGGAGATAGGGTCACGTTGGATGTTGAGTCAAGGAGTTTGAGG
|
6574103ACGTTGGATGATCTGAACCACTTCCAAGGCACGTTGGATGAGTAGACCAGAGAGCATTGC
|
8020478ACGTTGGATGAAAGAATCTGGCCTGGCATGACGTTGGATGTCGGGTTTTATCATGTTGGC
|
4903077ACGTTGGATGGCCTCCCAAAGTGCTAAGATACGTTGGATGACTATGCCTAGGTCTCCTTC
|
8012359ACGTTGGATGCATCCCGGAGAGAAACTTTGACGTTGGATGAATGCAGAATGGTGGTTCCC
|
4899449ACGTTGGATGCTTAATGCCACTGAAAACACACGTTGGATGGAGGCATTCCCTCAATTTTTC
|
10690289ACGTTGGATGTAGCTTGTGATCTGGGACACACGTTGGATGGCCAGAAAGTTGTTGGCTTG
|
6574104ACGTTGGATGGAACAATGCTGGCACATGTCACGTTGGATGACCTGAGATGATCACAGTCC
|
2110552ACGTTGGATGTATTGGTCCGGTTACTGGTGACGTTGGATGCCCTCAGTGACAGTTTTACG
|
8008256ACGTTGGATGTAGTTGTTTGAGTGACTGGGACGTTGGATGACTGTGAAACACCAGTAACC
|
759283ACGTTGGATGCGACAGAAAGAGCTAAGAGGACGTTGGATGTGCTGTGGCACTCAGTTTAG
|
4999177ACGTTGGATGGAGCAACACCCTGTCTCAAAAACGTTGGATGTTGATTTGTGCATACCTGGG
|
2333006ACGTTGGATGATAGCATTATGTTTCCCAGGACGTTGGATGTGGATTTGATAAAGGCCTGC
|
8006178ACGTTGGATGGCGCAGTATCTCTAAGCTTGACGTTGGATGAAACACGCACCCTACTGTGA
|
11158986ACGTTGGATGACCGCTGATGCTGTTTCTACACGTTGGATGCAGCCCGGTTATGTGATTTC
|
7150625ACGTTGGATGCGGACTTGGCGGCTTAACAGACGTTGGATGCTGCCTTCCTCCTCCTTTTC
|
8007768ACGTTGGATGACTAAAGCCAGCTCGCTCGCACGTTGGATGTTTCCCCGGCAGCCCCCGGAT
|
8007058ACGTTGGATGAAACTCCCCGCGAGCGATCGACGTTGGATGCTGGGTCCAGCGGACGGAC
|
DPF3-AAACGTTGGATGTGTGATTGGCCCGTCGCTTCACGTTGGATGGGTTGTGAATGACAGTCGCC
|
2215901ACGTTGGATGAAAAGGGAGTGACCTCTGGGACGTTGGATGAATCGGCGCTGCTGGTAGCTA
|
3814866ACGTTGGATGATAATACTCTCCCGTGCGTCACGTTGGATGAGAGCCAGCAGGTCTTAAAG
|
3814864ACGTTGGATGAGGGTAAATCCCCGTGTTTCACGTTGGATGACGGCAGAGCACATGTAGTA
|
TABLE 43
|
|
|
dbSNP rs#
Extend Primer
Term Mix
|
|
|
11846274
GTGCCCTTCCCACGTGTG
ACG
|
|
2526935
GGTTTTGCCTTGGGCTGCTT
ACT
|
|
929328
AGAAGCTATAGCTCTGAGCC
ACT
|
|
3742840
CGTGCTGGCTTAGACTCTC
ACT
|
|
9671739
GGAGGTGCAACTGGCAGG
ACT
|
|
8006208
TGAAGGCTAGGCCAGCATG
ACG
|
|
8006230
CCTTGGCAGGGCATCGACT
ACT
|
|
8007836
ATGGACTCTGTTCCCTTTCC
ACG
|
|
8006889
GGCATTTGTGCTCCTCTGG
ACG
|
|
8010823
CAAATGCCATGTGGACCAGA
ACG
|
|
8011029
GGGAAGCAACAGTGGCGTA
CGT
|
|
10649920
GCAGAGGGAAGGGAGGAAA
CGT
|
|
2803956
AAGTACCCAACTATTGCCAAAT
ACT
|
|
2803957
GTGTGTGTATGTGCGTGCG
ACG
|
|
2526934
GTTGTGTTGCTGAGGGAATAT
ACT
|
|
9671558
CACAGCCAGGGCTCACTCA
ACT
|
|
2526933
TCCGGGCTTGCCAGTTCC
ACT
|
|
2803959
GGGATGTGGGAGGATAGACA
ACT
|
|
2526932
TCTTACTCCCATCCCCAAAG
ACG
|
|
2803960
AAGTGGACAGAGCTCCTCC
ACG
|
|
12434675
GGTCCCCATGTCTCAGCC
ACG
|
|
4899435
CAGAGAGGTGAGGCTGCCA
ACT
|
|
2526931
AGGTGACATTGGTAAAGATCC
ACG
|
|
2803961
GCATGGTCTTTGCAGGTATTC
ACT
|
|
2803962
AGGCGGACATGGAAAACATC
ACG
|
|
12590634
GCTATTGTGGCACTTGGGAA
ACG
|
|
11327712
TGTCTCCAAAGGCTAATAATTG
ACT
|
|
2803963
CTCCCCACCTC1TTCTTCTA
ACT
|
|
11844834
CCAGAACGCGCCCTCCTC
ACG
|
|
11320415
CCACTGCATGTCTGGGAAAA
CGT
|
|
8012752
GGCGTCTTGGAGGAGGTAC
ACT
|
|
11623878
ACAGGCATGCGCCACAGC
ACT
|
|
11623926
ATCCCAGCTACTCAGGAGG
ACG
|
|
12434442
TCTGATCGTATCACTCCCCT
ACT
|
|
2526930
GTCTGGGCCTGAGATATGGA
ACG
|
|
12435306
GATTCCCATTCTGCTGGAAC
ACG
|
|
10144028
GCCCCAACAACCTCACCC
ACT
|
|
4899436
GCCAAAGACCAGCGTCAAC
ACG
|
|
7140593
CATTTGCCTCATTTTTCTTTTGT
ACT
|
|
2107687
GGTCTGGAGCATAAAATGTATAA
ACT
|
|
991882
CAAATACTGTACTCTAGTTAATTT
CGT
|
|
3327
CTTTGTCCTCAATTTTTAACACT
ACG
|
|
2526928
GATATCCCACAATCACTATTTTTA
ACT
|
|
7401336
AAAATGTCAGACAGCACAGAG
ACT
|
|
2526926
AATATCTGTAGGTGCATATAAAC
CGT
|
|
994760
GAAACAACAGCATTAGGGCC
ACT
|
|
994759
CCCACATTCTTCACCACCC
CGT
|
|
994758
CCTGCTGGGGAATATGGTCT
ACG
|
|
11848404
GTCCGTGGTACTGTTCAGG
CGT
|
|
2526925
GCTCCATTTCTTTGCCATCC
ACG
|
|
11844236
CTTGGATGACATTCCCAAGTC
ACT
|
|
2526924
ATTGGCTTTGCCCTGGGTG
ACG
|
|
2803965
CCCTCTCAAGGTGATACCAT
ACT
|
|
2526923
TAGGATAACTATTCATTAACTTAC
ACT
|
|
7152467
AACTAGTCACATCTGAATAAAGT
ACG
|
|
11623462
AGGGGTGGGAGGGTACAG
ACT
|
|
2803966
ACAGCCTCAAGCCCCCGA
ACG
|
|
2526922
AATAATACACACTGTTAGACAAAA
ACT
|
|
2526920
CACCACTGACCCAGCTCAA
ACG
|
|
11848135
ACTAACACTAGTTTTGCCTGG
ACT
|
|
11629210
GCTGCCAATTTCTATGCACG
CGT
|
|
2803967
AAAATTATCTTCCTAGGTATGCA
ACG
|
|
16455
CAGTGTGTGAAGGTCAGGC
ACT
|
|
757655
GTCAGGCGGCTGAATCATTG
ACG
|
|
5809581
GTTTTCCACCAGCTATACATCA
CGT
|
|
3057139
GTTTTCCACCAGCTATACATCA
CGT
|
|
2247658
ACAGGCGCCCGCCACCA
ACG
|
|
11625609
CCTTAAAGGATAAATAGGAGTTTT
ACG
|
|
8005580
TTGCAGGAGATGATGCTAGAA
ACT
|
|
8010472
TCCCCAGCCATCTCCAACA
ACG
|
|
2526919
GAGGCACCTCATGACATCC
ACT
|
|
2803968
ACAGTGTAATGGAGGTGTGG
ACG
|
|
11623943
GTTGTGGGTGTCTCGATTGTA
ACT
|
|
11623946
GTGGGGTTGTGGGTGTCTC
ACT
|
|
1557926
GATTGAAAGGAGCCAGTGAG
ACT
|
|
12434611
GGATAGCTAAATATGTGGCAC
ACT
|
|
2526918
TGACAGCCACTTGGAGTGC
ACT
|
|
5809582
CCTATCTCTGAAAAAAAAAAAAAAA
CGT
|
|
8008279
GTTTCACTCTGTCACCCAGG
ACT
|
|
2803969
GCCAGGCATGGTGGCACAT
ACT
|
|
2526917
AGCATAGGGAGACCCCATC
ACT
|
|
8008774
CTGGTGGAGTAGAAAAAATATTA
ACT
|
|
2803970
GAAGGGATTTTTTAATGATGGC
ACT
|
|
8010255
CCATGGTGGGAAAAGAAGAG
ACT
|
|
2997642
TTTCCCACCATGGACCCCA
ACT
|
|
2803971
GCGTTGAGGGTGTGGGATG
ACG
|
|
11313760
TCCCATTCATGGCCAAACCT
ACT
|
|
2803972
CTAGGTCAGATCCGGGGTG
CGT
|
|
4903038
GGTGATTCGCATGCACAGG
ACT
|
|
2526916
AAGTCCTGGGAGGATGGGA
CGT
|
|
4903040
CTGCTTACAGCTCTGCAGC
ACG
|
|
2803974
CTGCAGCCACTAAGTGGAG
CGT
|
|
2803975
TCCCTGAAGACCTTTCTCCA
ACG
|
|
2803976
ATGACTGGATTCAACAGCCC
ACG
|
|
2803977
CTTTTGATCATTTTCTATTTTAGC
ACT
|
|
10139909
GGCAGTGAGGCAGACACCA
ACG
|
|
722945
GCCAGGAGCTCCAGTCCA
ACG
|
|
917069
GTATGCTGGCTGAATGGTCT
ACT
|
|
2803978
CTTCCCCTCAATGTCTTCTAT
CGT
|
|
2332890
GGTTGGGAACCCGAAGAATA
ACT
|
|
1989638
GAGAGAAGCAACAAAGTGAGAA
ACT
|
|
10679174
TACATTAATCCCCCCCCCC
CGT
|
|
2526915
GGCCGAGCGGTGTAGTGG
ACG
|
|
2526914
AAGGCCACTTCCAAACCCC
ACT
|
|
11158964
AACAGACAGCAGAGAGCCAT
ACG
|
|
11158965
CTTCCTGTTCAGCCACCAC
ACT
|
|
740081
CCCCCTGTCTTCCTGACTT
ACT
|
|
740080
TTGCCTCTTGTTACCCCATTT
ACT
|
|
10140582
CTGGCTGTGAGACTGTCAG
ACT
|
|
2526913
AGTGGGAAATACCTGAGCAAA
ACT
|
|
4899437
TGCCTTACACAGTGGAGAAG
ACT
|
|
10145678
TTCAGAAAAGAAGTGATCGGC
ACT
|
|
2107686
CTGAGAATAATATCCAAGTCCT
ACT
|
|
2107685
GCTCGTGGCTCATGCTACC
ACT
|
|
2107684
CAAAAGGCTTGAGACATTGCTT
ACG
|
|
7154188
CTTGGCTATCAGTGAGTTCC
ACT
|
|
4903041
AGGTAACCAAACGATGTGTGT
ACG
|
|
7159637
CTACCCTGTGATCACATATGAA
ACT
|
|
6574089
GGTTTCTTAGAAAAGAAGGGTAA
ACT
|
|
12589753
CCATAGATTAAGGCAAAGATCC
ACT
|
|
4899438
GATGAGAGGTCTGGCATGAA
ACT
|
|
4903042
AACACAGAGTAAAATGAAGTTTC
CGT
|
|
4903043
CCACGTATCTTTTGATGAACAC
CGT
|
|
2803980
TAAACCGCATTTAGCTTATCCA
ACG
|
|
10483848
GCTTTCTTTTTACTGCTAGGAA
CGT
|
|
2240344
GCTGACCAGAATACCCAGC
ACT
|
|
2286068
AGACGGCGGGTGTTCTAAC
ACT
|
|
11339669
CATCAGACATGATAACTAGGAG
ACT
|
|
3854
AAGAAAAATGCCCCACATTTTAA
ACT
|
|
11463
TAAAAGGAAAAAAGTGCTGACAT
ACT
|
|
1383
CGCCTTGAACTTCAGCAGCA
CGT
|
|
1381
ACCTGCCCTATTCCTGGCT
ACT
|
|
1377
CTGGCCAGAGGCAGAGAGA
ACT
|
|
11158966
AAAAAAAAATTCCCCTCCACTTA
ACT
|
|
11158967
TTTTCACAGTTAAAACACCCCA
ACT
|
|
11158968
TGATGTCATCTCTCTCCCTG
ACG
|
|
11158969
CTCTCCCTGCCATCCAAGTA
ACT
|
|
11158970
AGCCACAGAAAACCCCATCA
ACT
|
|
11158971
GGGACTGTCTCCGAGTAACT
ACG
|
|
11849782
GATAAGGGAGGGAGAAGAGG
ACT
|
|
10137616
TCAGGCACTGTCTGGAGGA
ACG
|
|
757572
GACAGTGCTGAGCAGTCACA
ACG
|
|
10140566
TCCTTCTCAGTGCATTACATC
CGT
|
|
2023480
GACTAACCAGTATCGAGGTTG
CGT
|
|
2526911
GTGGAAGCCTAGAGTGGAG
CGT
|
|
4903044
GTCTGCTCCAATTTTAAGTACA
ACG
|
|
11845162
CTTTAAGGGTTCCTGCTTACT
ACT
|
|
12147210
GCAAAGGAAGCTGGCCAGAT
ACG
|
|
2997643
ACTTTAGTGGTGGATGTGATAT
CGT
|
|
2997644
CATTGCATTGGAGGGAAATGT
CGT
|
|
3814867
GTCGTTCTTTGCCAGGAGG
ACT
|
|
2286067
GTTAATCCCTTTGGTGTGCAA
ACT
|
|
1060570
CCCAAATCCCCGTCACCAG
ACT
|
|
2332891
CACACACACACACAGACACA
ACT
|
|
2021736
AATAAATCAGAGCATCCTGAAAT
ACG
|
|
7160830
GTCCATTTGTGCAATTCTGTCA
ACT
|
|
2526909
TTCTTTGTTTTCCATTTCAGGG
ACT
|
|
7140963
GCACTTGGGGTCTTGGGCA
ACT
|
|
10143667
CATTTCCAGGGGCTGCTTGA
ACT
|
|
2803981
AAGATGAGATTTGGGTGGGG
ACT
|
|
768840
TCCTCCTTTGCCTTCTGCC
ACT
|
|
5809587
CCCTGCCATCCCTCTCTAA
ACT
|
|
2023479
GCTCCCAGGGCATCACTGT
ACT
|
|
4903045
AATATCATATTGGGCGAATCAG
ACT
|
|
4903046
CGGATCTCCGCTGTGGTGT
ACT
|
|
5809588
GCACAAATGCGCGGCCAC
ACT
|
|
10220555
GGCTGTGCTGCCCCAAGA
ACG
|
|
2906132
GGTGTGACAGTCATGTCACC
ACG
|
|
11848482
CCGGAAGTCATTCACTTAATCT
ACT
|
|
10129954
TGCTCTCAACACTTTCATCAC
ACT
|
|
252692
TTTAGGATTCATCCTTGCCTCT
ACG
|
|
4903047
GACTGGGTGGCTTAAACAAC
CGT
|
|
11846357
GCCTTGGGACTAGGGCCC
ACT
|
|
10136385
GGGCTCCACGTGTCTCTTG
ACT
|
|
12588242
CCCTGGACTGACCAACTCC
CGT
|
|
11621517
CCTCTTAGGAGCTCTGAGTA
ACG
|
|
2526910
GGGGTTTGCAAAGGCTTCAC
ACG
|
|
2526941
CCCCCAAGCTGATGCTCTC
ACT
|
|
2803944
CATCTCACAGTGCCCTCCT
ACG
|
|
12436770
GGGGAGGCCCCGGATCC
ACT
|
|
10220279
ACATGCACGCACACACACAA
CGT
|
|
10220280
GGGTGTGTGTGTGTCTATGC
ACT
|
|
11844112
CATGCCCTGGGGTTTGGAAT
ACT
|
|
12432455
CACCTGTGGCCAAGACCATT
ACT
|
|
8015338
TCGAAATGCCTGCTTGGCTA
ACG
|
|
3832969
TTCAGCCAGCCAGCCAGC
ACG
|
|
9671972
TAGTGTTTCACTGTTTAGAACG
ACT
|
|
9671975
TTAAGTAGTTCTTCTTATTCCTG
ACG
|
|
7159986
CCTTAACAAAGAAGTCCAACCA
ACT
|
|
11848220
CTTCCTCTCTCTCATAAATATTG
ACT
|
|
5016369
GTTGTCCAGAACAGCCTTCTA
ACT
|
|
1986423
GAGATGGGCGAAGAGGCAA
ACT
|
|
2332909
ATGGGCGAAGAGGCAAATTG
ACG
|
|
8013337
CAATTGAAATAGCCCCTCGC
ACG
|
|
11445680
AGGTCCTGTGTATCCGCAG
ACT
|
|
4903048
GGTAAACACTCAATAGCTGTTG
ACT
|
|
12434793
TCAAGACGTTTCTTTCCATTGT
ACT
|
|
2332910
GGGCAAACACTCCTTCTGCA
ACT
|
|
4410017
GGAGAACGGAGGGTGGGAA
ACT
|
|
4577019
GAGAACGGAGGGTGGGAAG
ACT
|
|
2332911
ACCTGCTCAGACTGGGTAC
ACT
|
|
4996747
CTGGGTACGCAGGGTACAG
ACT
|
|
10140820
TAGCTTCAGGACCTACAGAG
CGT
|
|
12431623
GGACATCTCTAGGAAGGTTG
ACT
|
|
6574090
TTTGTGCTCCTGTTAGAATCC
CGT
|
|
8008750
CTGATGTTCCCAGCAACCCT
ACT
|
|
11627420
GGGCAGGGAGTGGTCACA
ACG
|
|
10150185
TCACCACACTGACTTCCACA
ACT
|
|
10150218
ACGTACCATTTTAACGCCCC
ACT
|
|
9646164
GAGTGGGGCAGCGGGGC
ACT
|
|
6574091
CACGTGAGCCTTAAAGAATATG
ACG
|
|
2332912
CAGGAATTAAGACCATGATTCA
ACT
|
|
7155359
CTGCAGTTAGCAGCTACAATA
ACT
|
|
2332913
GAAGCTTGGAGCAAGAACACA
ACG
|
|
4544184
ATTTAACCCTTCCTGGAATGC
CGT
|
|
4337224
GGTCTACACTTAAGCATGGCA
ACG
|
|
2332914
GCATCAGACCCCATGCCC
ACG
|
|
4280167
CGGTCCCACCTTCCTTCCT
ACG
|
|
4903049
CTAGTAGAAACCACCTCTTGG
CGT
|
|
3742837
CACGGTAGTGTGTGGGAATTT
ACT
|
|
10139937
CCCACACACTACCGTGCC
ACT
|
|
12434292
TTAGCCTCCTAGCTTCACTG
ACT
|
|
11620671
GGGATGGACACAGAAGCCT
CGT
|
|
10140184
GCCCAGTGCACGAGTGTAG
CGT
|
|
2332915
CCTCCCTCCCTCCCACCA
ACT
|
|
2332916
GGGACTCTTCCTGAGGCAG
ACG
|
|
8012759
GTCACCTCCTCAGAGAAGC
ACG
|
|
10149272
CTTAGTGCTGTCCCCTGTG
ACT
|
|
11158973
TTATTATGACCCCCTAACACTT
ACT
|
|
4903050
CCTTTGGCTGGTCACCTTC
CGT
|
|
10666445
CAGAAACCACCTGGGTTCCT
ACT
|
|
2536143
GACAGACTCGGTCCCAAGC
CGT
|
|
10638231
CACCCTTGCTATTTTTTTTTTTTTT
ACT
|
|
12431636
GGCTCAATCTCGGCTCACT
ACT
|
|
8005904
CCTCGTGATCCACCCGCC
ACG
|
|
11621058
CTGTAACCAGAGGTGCACAC
ACG
|
|
10133224
CTAAGGTAGGGATTACAGAATA
ACT
|
|
12433185
CAGTTCAGCTGTTTTGCCCA
CGT
|
|
740974
GGACCATTTCCCACACTTGC
ACT
|
|
740973
GTGCATGTCCAGACCCACTT
ACT
|
|
740972
TCGAGCTTGGACTTCCTGG
ACT
|
|
740971
GCCCAGGAAGTCCAAGCTC
ACT
|
|
4243642
AGAGGTATGCTGTGGAATCC
ACT
|
|
4415952
GCTTCTAATATAGTATAAAGCCC
ACG
|
|
2215589
GAGCCTGAAGGGGTGAGAT
ACG
|
|
4343211
GGGACCTCCAGAAGTAAACT
ACT
|
|
2536142
GCTTTTTCCTTGTCCCATCC
ACT
|
|
11293340
TTATAGTCATGATTATGGTTTATTT
CGT
|
|
10151620
ACGACCTGGGATCAGAGCT
ACT
|
|
2286840
CAAAGGCAGCGTCTTCACTT
ACT
|
|
8023089
CCCTTTTCTATGTGGGGCCA
CGT
|
|
8008009
CAAAACTGTTTTCAGCCTCAG
ACG
|
|
11419089
CCCTGTCTCAGAAAAAAAAAAAAA
CGT
|
|
10694676
CCCTGTCTCAGAAAAAAAAAAAAA
CGT
|
|
2536141
GGTTGAGGCTGCATTGAGC
ACG
|
|
765247
ACACAGTGAGCCCATAAAGAA
CGT
|
|
7147626
GGAGCCTGCCACGTAGTC
ACT
|
|
10132629
CCTAGCATGGAGCCTGCCA
ACG
|
|
4903051
CTCTTCTCAAAACAGTGGTAG
ACT
|
|
11158974
GACACCCCACCCCCGTC
ACT
|
|
1035021
GATGTGGGGCCAGCAATGG
CGT
|
|
6574093
GCAGTGGCTCTGCCCCAT
ACT
|
|
4899439
TGCCCTGGCCATTTCCCC
ACT
|
|
7155287
TCTGGGACAGGCCTGGCA
CGT
|
|
7154402
GAGAAGCCAATCTGAAAAGGC
ACT
|
|
7154781
CGGTTCACTCTTGGCGTTG
ACG
|
|
6574094
GGGGTCCCCAGCAGGTG
ACG
|
|
10132242
GCCGTGTGAGCCCACATC
ACG
|
|
10146959
GCATGGCCATGAGGAGGTC
ACT
|
|
10147466
CCCTGTCTCTAAAAGAGAAAGA
ACT
|
|
11626411
AGCTCCTGTCCTGGGGCT
ACT
|
|
4899440
AGAAACAGAGGGAGTCTGAC
ACG
|
|
10144553
GTAAGCCTCCTAAAGGCAGG
ACT
|
|
11627663
TGCTGTGTGGCTGTTGGTG
ACT
|
|
11627799
TTACATTCTGAGACTCACTCC
ACT
|
|
11851733
GAACCTATGGGAGCAAATCAA
ACG
|
|
10140317
TAGAAATACCAGATCGGATACA
CGT
|
|
8007375
AACACACTTCTATTGAGCCCT
ACG
|
|
4899441
TGACAGCTGCTGCCGCTC
ACG
|
|
11158975
GTGTGTGTGTGTGGTTTTTTTT
ACT
|
|
11419607
GTGTGTGTGTGTGGTTTTTTTT
ACT
|
|
2109793
GGCTCACTGCAACCTCCC
ACT
|
|
8023156
GTGGAAAGAAGGGAGCTCATA
ACT
|
|
10140579
CTGTGGCTCTGCCATGATTTT
ACG
|
|
7148199
GAATTTGCTGCAGACAGCTC
ACT
|
|
7146916
CACTGCTGGGTGGGTCTC
ACG
|
|
1990439
GTCACACAGACTTCGTCCC
ACG
|
|
6574095
CAGCTCCGCAGACCTGAG
ACT
|
|
10140037
GGGTGTGGAGGGGCACC
CGT
|
|
8007249
TCAAAAAGGTCATACCAATTCC
ACT
|
|
1990438
ACAGACCTACTACTAGGCCT
ACT
|
|
1990437
CTTCCTTTCCCTTCCCCTC
ACT
|
|
10146484
CTCAGATACATGAGCAGCACA
ACT
|
|
11627333
GGTGAGAGAAATCAGACTGTG
ACT
|
|
7155802
CAGATTAGCTGGCTGGGGT
ACG
|
|
2109792
GCCTGGTTGCAAACTCCTG
ACT
|
|
11429363
ACCTAGCTATTTTTTTTTTTTTTTTT
ACT
|
|
8004210
GGTGTCCTGTGTCCCAGCT
ACT
|
|
2098194
CTGTGTACTCACAGGCTCAA
ACG
|
|
2109791
CGCTAGGTGGTGCCCCAG
ACT
|
|
11381729
TCTCTCTCTTTCTTACTTTTTTTT
ACG
|
|
1160094
AATCTAGGTTGCCTGATTTCC
ACG
|
|
11628051
TCTTTCAAGAGATAATCCATGC
CGT
|
|
10136771
GGGGACTACAAGTGCATGC
ACG
|
|
10139903
AGGTACCTCACTCCTTCCTT
ACT
|
|
4903053
GCCTGGGCAACAAAGCTAGA
ACG
|
|
3742836
GGATCTTCAGGTGGGTGCA
ACT
|
|
3742835
GAAACTACCCTGACTAACCC
ACG
|
|
8003233
GTGCCACCCTGTGTGTGTG
ACT
|
|
11621588
ACCAGCAAGCCAACAAATCC
ACG
|
|
740981
GCATATGTGTGCGTGCATGT
ACT
|
|
8019492
CAGAGCAAGATTCTGTGAAAGA
CGT
|
|
8019644
TTCCTTCTTTCCTTCCTTTCTT
ACG
|
|
8019646
TTCTTTCCTTCTTTCCTTCCTT
ACG
|
|
8019653
AAAGAAAGAAAGAAAGGAAGGAA
ACT
|
|
11450794
AGGAAGGAAAGAAGGAAAGAAA
ACT
|
|
11348193
TCTTTCTTTCTTTCTTTTTTTCTTT
ACG
|
|
11450793
CCTTTCTCTTCTCTTCTCTTCT
ACG
|
|
11282735
CCTTTCTCTTCTCTTCTCTTCT
ACG
|
|
2191823
AGAAGCTGGAAAATATGACTTAT
CGT
|
|
12232220
ACAATGATGGCCGGGCGC
ACT
|
|
11158976
AAAATAAACTAATGCATACTTTGTA
ACG
|
|
4903054
TCCTTCGTAATAAACTGGCATT
ACG
|
|
11846755
CTGCCTCAACTTCATATGCCA
ACT
|
|
12431988
GCTATGCTAGTAGGGGAGG
ACG
|
|
12100526
TCTTGGACATTTTGGCTGTTAT
ACT
|
|
11622568
TCAACCTGTGGGTTTATGGG
ACT
|
|
9671230
AGTCCTGGAGAGGAGGAAG
ACG
|
|
12147487
AGTAGTTTCTGATGGCCTTCT
CGT
|
|
4903055
GCACATGCCACCACACCC
ACT
|
|
12147515
CGGCTCACTGCAACCTCTG
ACG
|
|
11625092
CAGAGATGAGGCAAGATAAGC
ACG
|
|
4899442
GACCTAACTACCAATTCACAG
ACT
|
|
2052146
GAGCTCTGATAGTGATTGTGAGT
ACT
|
|
10220553
CCTGGATATGTTTTTAAAAATGTT
CGT
|
|
10220565
CTGTAATCCCAGCGACTCAG
ACT
|
|
2332917
GGCTTGAATTTACCTGGCATAA
ACT
|
|
7158910
GTCCACTGCCCCCCGAC
ACG
|
|
8015749
AATATCCTCAGGGTTAACCTAT
ACT
|
|
8006812
TCTACCATCATCTCCAGGGA
ACT
|
|
8008338
GACCAGGTGTTGGCAGAGA
ACG
|
|
2052145
ATTCAGATGGGATCACAGAAG
ACT
|
|
2052144
ACTCAGCTCTCAGAGCTGG
ACT
|
|
10146692
GAGGCGCCTCTTCCTCACT
ACT
|
|
11627305
CCGCCCACAAACACACACG
ACT
|
|
2079989
GGAGGAGGCATGTCACATGA
ACG
|
|
8018881
TCAGGTCAGGAGGATGGAG
CGT
|
|
4561387
AGAAGACAAATACTAAACATTGAA
CGT
|
|
11622025
GAGAAAGGAATGGCTATTGATT
ACT
|
|
740980
CACATTGGGTAAATGATGA
ACT
|
|
12433250
TGGAGAAATGAAAATCTCAGGA
ACT
|
|
5809590
GATGTCAGCAGCATTGAGAAT
ACG
|
|
758915
GACATCAGACCTATGCCAGGA
ACT
|
|
758914
CCCCAGTGATCCTGAGAAAT
CGT
|
|
7154229
ACAAAGTCTGCTAACTGGGC
ACG
|
|
12437188
AAGGGATACCTTTGTCCCCA
ACT
|
|
7159108
CAAGGAGCTGCCAAGGACA
CGT
|
|
4903058
CCACCTCACTTTTGTTGCATT
ACT
|
|
4899443
GTAGCCTCCACCTCCCAG
CGT
|
|
11848907
ACTCCAGCCTGGGCGACA
ACT
|
|
12432148
GGAGGTGTTAGTAGGAGAGA
CGT
|
|
12435078
TGCCATCTCCTCTACCTGG
ACG
|
|
6574096
CTCGACACATATCACTCAACA
ACT
|
|
11158977
GCTGGCAGGAGACCCCC
CGT
|
|
11629434
AATCCCATGCCAGCAGGTG
CGT
|
|
4378563
GGCCTCCATGCCCTGCTTA
ACG
|
|
2098195
TAAACCTTTCTATGTTCCTG
ACT
|
|
4633653
CTGGGACAGGGTATGATCC
CGT
|
|
7148350
GTGACCCTTCCACCATCAAC
ACG
|
|
740979
TGCTTTGGGGCAGACTGAC
CGT
|
|
740978
AAGCCTTCCTATCCCCA
ACT
|
|
740977
TGGTTTTCGAATAAGTAGCCAC
ACT
|
|
740976
ATCCAGATGGCCCTGAC
ACT
|
|
4903059
TCCACACCACGCTGCCTC
ACG
|
|
4903060
AGGCCAGAGAAAGAGGCGA
ACG
|
|
11852056
CCCCTCAAGAGCCCCATC
ACT
|
|
9635257
ACCACTGCCGCTGCCCC
ACG
|
|
9635258
CAGGGTTTGTTCTCTGTCTC
ACG
|
|
9635259
CCATCACAGCTTCAAAATCACA
ACT
|
|
4899444
AAATTCCTTAACCTCTGTGAAC
ACG
|
|
12435382
CTCCCCTGGGGCTTCCC
ACG
|
|
12435412
GGGCAGGTCCAATGAAAATCA
ACG
|
|
11627381
AGGACCCCACATTGTGGTAA
ACG
|
|
2052143
TCTACCTCCACTTCCAA
ACG
|
|
2052142
AGCCAGGATAATCTCCTCA
ACG
|
|
2052141
CTTACCCCCAAAGATGTCCA
ACG
|
|
8021035
GAGGCTAGGACCAAAGGAAC
ACT
|
|
11158978
CTCAGGAGGCTGAGGTGG
ACT
|
|
11621216
CATTTACCACTCACAGGGTAT
CGT
|
|
10130873
TTGTCACTTCCTCATGCCTC
ACT
|
|
11621358
CTTGTCACTTCCTCATGCCT
ACG
|
|
758913
CCAGTCTAGTTTTCGATCACC
ACT
|
|
11622602
CAACGTAGGATGTGGTGATC
ACT
|
|
10136931
CCATATTTTCAACATACATACATA
ACG
|
|
740975
ACCAGCTCTCTTTGGAT
ACT
|
|
747987
AACCTGGTTCTGCCATT
ACT
|
|
11623819
GGCAACTCCTTCCACAATGG
ACG
|
|
12434445
CTGAAGCAGCTGGGAGCC
CGT
|
|
8003375
CTGTCAGATGCCACACATCAA
CGT
|
|
10143596
AGATGGATAAATAGATAAATGGAT
ACT
|
|
12435321
TGACTGCAGTGGGCTGCC
ACT
|
|
12435401
TTTTGGGTGTCTGGAATAACG
ACT
|
|
8010609
GGCTGCCTGCCCAGATCC
ACT
|
|
11158979
GACACCAAAACCCAGTGCCT
ACT
|
|
11158980
ATATGCTCACAGTTCAGGCAA
ACG
|
|
11627524
TGCCTGGACAAGGCCCATA
CGT
|
|
1126160
GAAGCCCATCGCTAAGTGTTT
ACT
|
|
10136074
GGTGACACGTTGGGCTTGT
ACT
|
|
4903061
CAAAGGTAGTTGAATCTGATTC
CGT
|
|
10665398
TGTTTGTGTGTGTGTGTGTGT
ACT
|
|
6574097
GTGTGTGTGTGTCTGTGTGT
ACT
|
|
9671654
ACACACACACACAAACACACA
ACT
|
|
10140024
AGGCTGGGCACAGTGGCT
ACG
|
|
10142421
AGATCACCGCAACCTCTGC
ACG
|
|
10142593
GGCAACAAGAGTGAAACTCTA
ACG
|
|
11423372
TCTTGCTCTGTCACCCAGG
ACT
|
|
5809592
TCTTGCTCTGTCACCCAGG
ACT
|
|
2332918
TCTCTCTAATGGGGACC
ACG
|
|
2332919
ACTGGATCCCAGAAGAG
ACT
|
|
8007348
GGAGGCCAAGGAGTTTCAAG
ACT
|
|
1990443
TTCCCCTCAGCTCTTAG
ACG
|
|
8007690
TAGCCATCCTTCCTCAGATG
ACT
|
|
3937455
TCCTTTTTTCCCCACCC
ACT
|
|
8012823
GCTCCTGGAGGGCTTCCAA
ACG
|
|
4899445
CCCTCTCCAGGGCCATGC
ACG
|
|
4903062
CTTGGGCAAACTCCTTAAAATA
ACG
|
|
973963
AACAACCAACTCTCCAG
ACG
|
|
10149962
CAGCAGAACCGAGGTGAAAT
ACT
|
|
8003449
CATTTTCAGGGATGCCTCCT
ACT
|
|
11620775
GCACAAAGCAGCAGGGAAC
ACG
|
|
8009089
ACAGACACTCCCACATCATC
ACT
|
|
8008967
CCGACTTCTCACTCTTTCTG
ACT
|
|
12050132
CAGGCCTCCCCATGCACT
CGT
|
|
10133018
AAATAACCCCAAGAAGCAGAC
ACT
|
|
1990442
CTCCAACTCAGAACATGCTC
ACT
|
|
1990441
CATGAATGTGATTCACATTCTCC
ACT
|
|
8015833
GGAAGAGACGGGCGGAGAA
ACG
|
|
1990440
CGTCAGCAAATGTGTACCGA
ACT
|
|
4903063
CATTGAGATGGGAAGGGCAA
ACT
|
|
10139810
TTTTTCCCATCCCCACCCC
CGT
|
|
4903064
GTGTCAGCAGAAAAAGTGTAC
ACT
|
|
2159715
CATAGGGATAGGAATGGG
ACT
|
|
2109795
TCCCAGAATTTGGAGCC
ACT
|
|
2159714
CAAAAGGATCTGCAAAAG
ACG
|
|
11623107
TAGTGAGCAGGGGAGCCTA
ACT
|
|
7152005
GCTGACCCCAGGCAGGG
ACG
|
|
7152489
CTGGGGCTCGAGCACAGA
ACT
|
|
4479167
GGTGTCAGCAACCACACCC
ACT
|
|
4606655
GCACCTGCCATCATGACCA
ACT
|
|
4606656
CTGCCTTCCCGGTTAAGCA
ACT
|
|
4489943
GTTGCAGTGAGCCGAGATC
ACT
|
|
7142642
TGTTGTTTTAAGCTACTGAGTTT
ACT
|
|
8006233
AGGGTGTGTAATGTAACATTTC
ACT
|
|
8007559
GCCCTGCACTCCCACCCT
CGT
|
|
8006156
TCCCACCCTTGTACACTGC
ACT
|
|
1468662
CTCTGACTGAGGAGAGACC
ACT
|
|
11627048
CCGTGGAGGACCCCTGGA
ACG
|
|
6574098
GACCTCAGGTGATCCACCC
ACT
|
|
12433760
GCCAAGGTGGGCAGATCAC
ACG
|
|
12433780
GAAACCAGCCTGGCCAACA
ACG
|
|
12434506
GGGAAACACAGAAAGACCCTA
CGT
|
|
12434673
ATGGGTGTGAACGGTAGCTT
ACT
|
|
12431400
GCCATTTTAATGGGTGTGAAC
ACT
|
|
12431384
GTGGCTGTGCTTTTGGTTGC
ACG
|
|
4903067
GCTGCTAATGTACACAACAATG
ACG
|
|
2332920
GAGATGGGGTTTTCCCATGT
ACG
|
|
2215591
TTCAATAAAATGTACTCATTCAAA
ACT
|
|
12433064
GACCAGGAGTTCAAGACCAG
CGT
|
|
12436263
GACCAGCCTGGACAACATGA
ACT
|
|
12433097
TCACTGCAACCTCTGCGTC
ACG
|
|
12433184
GTGTGCATGCCACCACGC
CGT
|
|
8015900
TGTGACCTCAGCTCACTGC
CGT
|
|
11296981
AGATGTGTAGATGACTTACACT
CGT
|
|
11344025
AGATGTGTAGATGACTTACACT
CGT
|
|
11464204
CGAGAGCTCATCTCCACTAAA
CGT
|
|
11441172
GTGCCTGGCTAATTAAAAAAAAAA
CGT
|
|
11381807
CTCATCTCCACTAAATTTTTTTTTT
CGT
|
|
10873251
CCACCTTGGCCTCCCAAAG
ACG
|
|
2109794
AGCACTTTGGGAGGCCAAG
ACT
|
|
10873252
GCATGTGCTACCACGCCC
ACT
|
|
4520784
CCAGGTTCAAGTGATCCTCC
ACG
|
|
2877820
TGCCCTGTTCTGCACCTTTAAAA
CGT
|
|
2877821
CCCTGTTCTGCACCTTTAAA
CGT
|
|
4569195
AGGGAGAAAAAAATAAAAGGACA
ACT
|
|
11628905
GGGAGTGGGAGGAAGCCAA
ACT
|
|
2191822
AGGAAAGGAATGTCTGCCCC
ACT
|
|
2191821
ATGTGGGTTTGGACTGGGGCT
ACT
|
|
11464689
CGTTTTCTTTTTCTTTTTTTTTTTTT
ACT
|
|
12431959
GCTGAAGTAGGCGGATCAC
ACG
|
|
4903068
CTCTCTCACAGAGCACACTC
ACT
|
|
1544579
GACATGCATCAAAGCAGCTG
ACT
|
|
7155879
CCTTTTCGCTGAAAAGAGGG
CGT
|
|
12433603
GGAAGAAGCCCTCTTTTCAG
ACT
|
|
11351432
ACTCCATCTCAAAAAAAAAAAAAAA
ACT
|
|
11448438
CAAACCACTGTATAAGTCCAG
ACT
|
|
4243643
CTCAGCCTCCTGAGATGCT
ACG
|
|
4140952
CATGCTACAAGCAACCTTGG
ACT
|
|
8005372
AACAGTGGTTGAGTACCTGC
ACG
|
|
8004109
CATGACCCTGTACCCAGCAT
ACT
|
|
8008398
TCTATGAACCTGTTGAAGGCA
ACT
|
|
8009692
CTTCTCCTCCCCATAGCTCT
ACT
|
|
2332921
TGTCTCCAGGGTCTGGGG
ACT
|
|
12050320
CAGCAATCTATGCACAGAGAA
ACT
|
|
12050323
CAAAGGCTGAGAAAGACTGAA
ACT
|
|
8010316
AAATTTAACCATCATCTGCCAG
ACT
|
|
7154293
GGTCAACATGGTGAAACCCC
ACT
|
|
12147969
AAAATAAGCCTGGCGCACCT
ACG
|
|
2215590
CAGGGCCAGCCATGAACGT
ACG
|
|
4265749
GGATCATCCAAGTATGCTCC
ACG
|
|
1004552
TCTTGGCTCAGTGCTGC
ACG
|
|
4307892
GAGCAATGAACACCAATATCC
ACG
|
|
12431973
CTGAAGCAGGAGGATCGCTT
ACT
|
|
12431975
CGCTTGAGCCCAGGAGTTC
ACT
|
|
767874
CATTTGCCCTATCTGTAGTTC
ACT
|
|
11628597
CATCTCCCCGAGGCACCC
ACT
|
|
10129371
TCCAGTGATATGCTTCCCTC
ACT
|
|
4903069
GAACCTGGGAGGTGGAGGT
ACT
|
|
4903070
TGTTGGCCAGACTGGTCTC
ACT
|
|
4903071
GGGATCAGTAAACCTTTCCC
CGT
|
|
11622224
CTTCATGAAGGCCGCAGAC
ACT
|
|
10459455
CTCGACTCATGGCAACCTC
ACG
|
|
9323577
CTGGGCAACAGAGTGAGAC
ACG
|
|
10624648
CTTCCCTGACCCCCAAACAA
ACT
|
|
3058953
CTTCCCTGACCCCCAAACAA
ACT
|
|
11158981
ACCTCAAAACCTGACTATAGAA
ACT
|
|
11158982
CTCATCAAAAGTAAAATGGGAAAA
ACT
|
|
11158983
TTTTTGTTCATTGGCTAATTTCTT
CGT
|
|
1860750
CCTTAATCATGTTTATTTATTTATTT
CGT
|
|
1860749
TTAAGGATAAAGCAATCCAG
ACG
|
|
1860748
TCTTGGAGCCATATTTTATTTG
ACT
|
|
1860747
GACAGAGGAGAGCTCCCC
ACT
|
|
11419679
AGCCCAGTAGTAAGGAAAGAA
CGT
|
|
8011777
CAGAGTGAGACTCCGTCTCA
ACT
|
|
6574099
ATGTTAGCCAGGATGGTCTC
ACT
|
|
8010957
GATTATGAGCCACTGCACCC
ACT
|
|
11626895
GCCCATCTTCTTGGGTGTGT
ACG
|
|
10151431
CTGCCTCCTGGGTTCAAGC
ACT
|
|
4903072
GTGTGACAAGCCAATATTCCC
CGT
|
|
4589489
CCACACCATTACCAGGCCA
ACT
|
|
9671327
CCACTGTGCCCAGCCTAAA
CGT
|
|
4899446
GCTGGGCACAGTGGCTCA
ACG
|
|
10144501
AGATCATACCACTGCACTCC
CGT
|
|
5809594
GTGCGCACACACACACACA
ACG
|
|
720317
CATGTGTGTGTGTGTGCGC
ACT
|
|
8014316
CCCGGCATTCTCTAGCACC
ACG
|
|
11158984
GGGACGTTCAAAGGGGAGC
ACT
|
|
6420906
GTACAATGTACAAAATGTCCACT
ACG
|
|
8004055
CCCACAGACTCCTACGGG
CGT
|
|
12434800
TGTTGACTGCCTTACACACC
ACT
|
|
4243644
TTACCCTACAGCTGATTTTTTTT
CGT
|
|
4899447
CCTTGCGTGTGTGTGTGTGT
ACT
|
|
4903073
TATGCCTCAGCAAGCATGCA
ACG
|
|
11848634
TGCTGATTGTAAACAATGCACA
ACT
|
|
4899448
CTGCTCTTGACTAGTCTTAAAAA
ACT
|
|
10131564
CTCTGTCACTGACTGGCCC
ACT
|
|
10134150
AGAAGAAGCATTGGTCTGTTTA
ACT
|
|
763388
CACTCATGCCTCAAGCCAAT
ACT
|
|
11845938
TGAGGCATGAGTGATCAGCA
ACT
|
|
11845946
ACCTAAGTTTCCTGACATTCC
CGT
|
|
11845915
TACAATTCACCCAGCTCCTC
ACT
|
|
10137463
CCATCTGCCTGTCCTCCTG
ACT
|
|
6574100
CAAGAGCTGGAGTGATTTGTTT
CGT
|
|
7140344
ACATGCTAGGAAGTAGGCAAT
ACT
|
|
10646889
CACCTGGGTTTTTTTTTTTTTTTTT
ACT
|
|
7146287
TTGAACATGCAAAGTATTTCTGA
ACG
|
|
10605948
GCTTCCTCCCCCCCCCC
CGT
|
|
5809595
CACCATTTCTGTTTTTTTTTTTTTT
ACT
|
|
1035099
TTGGTCAACATCGCAGC
CGT
|
|
7159877
ACAAACCTCCACCTCCTGG
ACT
|
|
7142579
CATGTCACAGTTCTGAATAGAG
ACG
|
|
12431762
GAGCTAGGGGTCTGAATTAG
ACG
|
|
12431764
ACTTAAGGAGAGCTAGGGGT
ACG
|
|
10647999
CTTTCTTTCTTTCTCTTTCTTTCT
ACG
|
|
6574101
GGAGCTCAGTGGCACACGA
ACG
|
|
6574102
GAGCAAGTGGAAGATGAGAC
ACT
|
|
1861162
CGATGTGTAGAAAAGGGCAC
ACT
|
|
12432972
GGAGGCCGACACTGACCA
ACT
|
|
10146134
TTATACTTTTGATGGCTCCTAC
CGT
|
|
10146616
TCCTGACCATTCTACTGCCT
ACT
|
|
10146769
GGTCAGGAGGAGAGAGGGA
ACT
|
|
8018936
GGCAAGGACATAAAGCTTCAT
ACG
|
|
10483849
GCCTGGAGATTTCGTGGTC
ACG
|
|
2160137
GGGTACCTGGGAGTCAGAC
ACT
|
|
2192595
CTTGGGCATCCTAGTAGAGA
CGT
|
|
2192594
CGGATTTTCATGTCCTGGAAA
ACT
|
|
11271695
CTCCTGCCATGATTCTGAGG
CGT
|
|
10747301
GATTTCAGACCTACCTGGGC
ACT
|
|
12050363
GTACAGCCTCCCTCCTGC
ACT
|
|
12050368
GCCTGGAAAAGCTGCAGAGA
ACG
|
|
12432949
ACCCCATCAACAAGTGGGC
ACT
|
|
7401375
ACCATCTCACACCAGTTAGAA
CGT
|
|
8019682
ATGTTTTAGCGAAGAGACTGG
ACG
|
|
8021248
ATTTTCTCTTGCTGCTGCCAT
ACT
|
|
11158985
GTGAGGACACAGCCAAACC
CGT
|
|
10483850
GGAAGGAAGTGGCCAGCAC
ACT
|
|
8010875
CTCATTTTTCCCTTCTGTTCAC
ACT
|
|
11626844
CCTGAGAGAAGCTGCTTCAC
ACT
|
|
982972
AAGCACTGAAGGGGCACAAA
ACT
|
|
7161198
ATAGAGATACCAGCGTATCATT
ACT
|
|
7160347
TTAGCTTTATTTATACTGGAGGA
ACG
|
|
8007139
GATTCCATCTCCAAAAAAAAAAAA
ACT
|
|
8014483
ACTCTCCAAGGCAACTCACT
ACG
|
|
12437072
CCAACGTCACAGTCCTAAGT
ACT
|
|
8004767
GCACCGCGTTGCCGCCC
ACT
|
|
12588830
TGCCCTGCCAAAAAACAAGG
ACT
|
|
7158449
CCCAGGCTGGAGTGCAGTA
ACT
|
|
6574103
GGCTGGCAACCAAGACATG
ACG
|
|
8020478
GGTGGCTTACGCCTGTAATC
ACG
|
|
4903077
ATTACAGGCATGAGCCTAGC
ACG
|
|
8012359
CGGAGAGAAACTTTGTATGCA
ACG
|
|
4899449
AATGGCTAAAATGGTACACTGT
ACT
|
|
10690289
GTGATCTGGGACACAGAACTT
ACG
|
|
6574104
CTGGCACATGTCTAATCCCC
CGT
|
|
2110552
TCCGGTTACTGGTGTTTCAC
ACT
|
|
8008256
GGGGAGAGATGAGGTGTTG
ACG
|
|
759283
CAGGAATGTGACCCCCACC
CGT
|
|
4999177
AACACCCTGTCTCAAAAAATAAT
ACT
|
|
2333006
CATTATGTTTCCCAGGTATGCA
ACT
|
|
8006178
TCTCTAAGCTTGTGTTCCCC
ACT
|
|
11158986
TACCGAACCCACAACTGATTT
ACT
|
|
7150625
GGCGGCTTAACAGTTCCAC
ACG
|
|
8007768
TACACGAGCAGACACACGC
ACT
|
|
8007058
GAGCGCCCTGCAAACTCC
ACT
|
|
DPF3-AA
CCCGTCGCTTCCCCTGAG
CGT
|
|
2215901
CTCTGGGCTTTGACAGCTC
ACG
|
|
3814866
GAAAAGGAGCTACCAGCGC
ACT
|
|
3814864
TGGAAGGCTGCCGTTTCGT
ACT
|
|
Genetic Analysis of Allelotyping Results
Allelotyping results are shown for cases and controls in Table 44. The allele frequency for the A2 allele is noted in the fifth and sixth columns for breast cancer pools and control pools, respectively, where “A” is allele frequency. SNPs with blank allele frequencies were untyped.
TABLE 44
|
|
Breast
Position inChromo-Cancer
dbSNPSEQ IDsomeA1/A2p-Associated
rs#NO: 6PositionAlleleCase AFControl AFValueORAllele
|
|
1184627420771066357G/AG = 0.001G = 0.0020.8973.28A
A = 0.999A = 0.998
252693548671066636T/GT = 0.749T = 0.6990.1340.78T
G = 0.251G = 0.301
929328174571067895T/CT = 0.559T = 0.530.3720.89T
C = 0.441C = 0.470
3742840192271068072A/GA = 0.999A = 0.9980.9350.68A
G = 0.001G = 0.002
9671739219071068340A/CA = 0.001A = 0.0010.9630.49A
C = 0.999C = 0.999
8006208259071068740C/TC = 1.000C = 1.0000.9910.31C
T = 0.000T = 0.000
8006230263771068787T/CT = 0.002T = 0.0030.9241.99C
C = 0.998C = 0.997
8007836280471068954C/TC = 0.001C = 0.0010.9760.60C
T = 0.999T = 0.999
8006889280671068956G/AG = 1.000G = 1.0001
A = 0A = 0
8010823289571069045C/TC = 1.000C = 0.9990.9110.26C
T = 0.000T = 0.001
8011029310971069259A/TA = 0.997A = 0.9990.8581.89T
T = 0.003T = 0.001
10649920318571069335—/AA— = 0.579— = 0.5750.8810.98—
AA = 0.421AA = 0.425
2803956335571069505A/GA = 0.621A = 0.5710.1180.81A
G = 0.379G = 0.429
2803957364271069792C/TC = 0.732C = 0.7580.3821.15T
T = 0.268T = 0.242
2526934380571069955T/CT = 1.000T = 1.0000.98C
C = 0.000C = 0
9671558423671070386A/GA = 0.001A = 0.0010.9510.36A
G = 0.999G = 0.999
2526933433171070481C/GC = 0.699C = 0.7050.851.03G
G = 0.301G = 0.295
2803959450971070659T/CT = 0.565T = 0.5580.8290.97T
C = 0.435C = 0.442
2526932495971071109C/TC = 0.559C = 0.60.2261.18T
T = 0.441T = 0.400
2803960500971071159G/AG = 0.002G = 0.0020.9521.47A
A = 0.998A = 0.998
12434675567671071826G/AG = 0.71G = 0.6820.3440.88G
A = 0.290A = 0.318
4899435650771072657G/CG = 0.002G = 0.0030.9321.52C
C = 0.998C = 0.997
2526931669571072845C/TC = 0C = 0.0010.906T
T = 1.000T = 0.999
2803961671771072867T/CT = 0.509T = 0.4940.6470.94T
C = 0.491C = 0.506
2803962713171073281C/TC = 0.443C = 0.4260.5980.93C
T = 0.557T = 0.574
12590634787371074023C/TC = 0.639C = 0.6120.3930.89C
T = 0.361T = 0.388
11327712792271074072—/C— = 0— = 01
C = 1.000C = 1.000
2803963865271074802A/GA = 0.525A = 0.5770.1091.23G
G = 0.475G = 0.423
11844834981771075967G/AG = 0.998G = 0.9880.3090.23G
A = 0.002A = 0.012
113204151027271076422—/A— = 0— = 01
A = 1.000A = 1.000
80127521082371076973T/CT = 0.002T = 0.0020.9251.65C
C = 0.998C = 0.998
116238781146571077615T/CT = 0.127T = 0.1040.2640.79T
C = 0.873C = 0.896
116239261163971077789C/TC = 0.975C = 0.980.7161.21T
T = 0.025T = 0.020
124344421217771078327T/CT = 0.354T = 0.4120.05841.28C
C = 0.646C = 0.588
25269301260471078754G/AG = 0.929G = 0.9110.320.78G
A = 0.071A = 0.089
124353061336371079513G/AG = 0.425G = 0.4550.3541.13A
A = 0.575A = 0.545
101440281345471079604C/GC = 1.000C = 1.0000.972.29G
G = 0.000G = 0.000
48994361354071079690C/TC = 0.999C = 0.9990.9660.75C
T = 0.001T = 0.001
71405931392371080073A/CA = 1.000A = 0.9990.9810.76A
C = 0.000C = 0.001
21076871450771080657T/CT = 0.999T = 1.0000.9263.80C
C = 0.001C = 0.000
9918821655071082700C/AC = 0.001C = 0.0020.8753.36A
A = 0.999A = 0.998
33271764171083791C/TC = 0.003C = 0.1542.36E−0760.70T
T = 0.997T = 0.846
25269281890371085053T/CT = 1.000T = 1.0000.9940.90T
C = 0.000C = 0.000
74013361939571085545A/GA = 1.000A = 1.0000.9552.83G
G = 0.000G = 0.000
25269261952771085677T/AT = 0.953T = 0.90.004030.45T
A = 0.047A = 0.100
9947602036971086519T/CT = 1.000T = 1.0000.9490.36T
C = 0.000C = 0.000
9947592050571086655G/TG = 0.469G = 0.5110.1811.18T
T = 0.531T = 0.489
9947582056271086712C/TC = 0.916C = 0.8840.1180.70C
T = 0.084T = 0.116
118484042090771087057A/TA = 0.002A = 0.0080.5534.19T
T = 0.998T = 0.992
25269252094971087099C/TC = 0.999C = 0.9980.8810.46C
T = 0.001T = 0.002
118442362127871087428T/GT = 0.008T = 0.0360.09964.84G
G = 0.992G = 0.964
25269242131471087464C/TC = 0.005C = 0.0020.8180.36C
T = 0.995T = 0.998
28039652190571088055C/GC = 0.767C = 0.7810.6191.08G
G = 0.233G = 0.219
25269232225271088402G/CG = 0.179G = 0.1890.751.07C
C = 0.821C = 0.811
71524672294171089091C/TC = 0.999C = 0.9980.9410.73C
T = 0.001T = 0.002
116234622354271089692C/GC = 0.205C = 0.1680.1730.78C
G = 0.795G = 0.832
28039662467771090827C/TC = 0.44C = 0.420.5220.92C
T = 0.560T = 0.580
25269222500971091159T/CT = 0.543T = 0.5340.7770.96T
C = 0.457C = 0.466
25269202561871091768C/TC = 0.604C = 0.6160.7151.05T
T = 0.396T = 0.384
118481352608271092232T/CT = 1.000T = 1.0001
C = 0C = 0
116292102613671092286C/AC = 1.000C = 1.0000.9840.59C
A = 0.000A = 0.000
28039672649171092641C/TC = 0.001C = 0.0010.9890.88C
T = 0.999T = 0.999
164552887371095023—/GCC— = 0.725— = 0.7450.4981.11GCC
GCC = 0.275GCC = 0.255
7576552888671095036G/AG = 0.613G = 0.6650.1061.25A
A = 0.387A = 0.335
58095812910571095255—/TCTGTAAT— = 0.005— = 0.0020.7610.39—
TCTGTAAT =TCTGTAAT =
0.9950.998
30571392910671095256—/CTGTAATT— = 0.005— = 0.0040.8540.67—
CTGTAATT =CTGTAATT =
0.9950.996
22476582957271095722C/TC = 0.801C = 0.7970.8820.98C
T = 0.199T = 0.203
116256093064071096790C/TC = 0.999C = 1.0000.8913.18T
T = 0.001T = 0.000
80055803080171096951A/GA = 0.998A = 0.9980.9660.84A
G = 0.002G = 0.002
80104723096271097112G/AG = 1.000G = 1.0000.9170.18G
A = 0.000A = 0.000
25269193166271097812T/CT = 0.557T = 0.5390.5820.93T
C = 0.443C = 0.461
28039683437471100524G/AG = 0.359G = 0.3080.08740.79G
A = 0.641A = 0.692
116239433449471100644T/CT = 0.001T = 0.0020.9032.17C
C = 0.999C = 0.998
116239463450171100651G/CG = 0.002G = 0.0020.9670.77G
C = 0.998C = 0.998
15579263454471100694C/GC = 0.646C = 0.6580.6921.05G
G = 0.354G = 0.342
124346113549371101643A/GA = 0.486A = 0.5280.1931.18G
G = 0.514G = 0.472
25269183559471101744T/GT = 0.998T = 0.9980.9921.04G
G = 0.002G = 0.002
58095823590171102051—/T— = 0.93— = 0.9250.7840.93—
T = 0.070T = 0.075
80082793594071102090C/GC = 0.835C = 0.8520.5051.14G
G = 0.165G = 0.148
28039693606471102214T/CT = 0.993T = 0.9910.8630.76T
C = 0.007C = 0.009
25269173610571102255T/GT = 1.000T = 1.0000.9513.23G
G = 0.000G = 0.000
80087743616071102310T/CT = 0.375T = 0.3380.2190.85T
C = 0.625C = 0.662
28039703616171102311T/GT = 1.000T = 1.0000.9910.82T
G = 0.000G = 0.000
80102553630871102458T/CT = 0.778T = 0.8120.21.23C
C = 0.222C = 0.188
29976423633571102485A/GA = 1.000A = 1.0000.9712.42G
G = 0.000G = 0.000
28039713636571102515G/AG = 0.352G = 0.3150.2230.85G
A = 0.648A = 0.685
113137603648871102638—/G— = 0.369— = 0.3270.1630.83—
G = 0.631G = 0.673
28039723657671102726G/TG = 0.003G = 0.0050.8141.84T
T = 0.997T = 0.995
49030383664171102791A/GA = 0.001A = 0.0020.8874.87G
G = 0.999G = 0.998
25269163693371103083A/TA = 0.998A =
T = 0.002T =
49030403695571103105C/TC = 1.000C = 1.0000.9530.51C
T = 0.000T = 0.000
28039743696771103117T/AT = 0.986T = 0.9980.4575.99A
A = 0.014A = 0.002
28039753724371103393C/TC = 0.264C = 0.2350.3650.86C
T = 0.736T = 0.765
28039763832971104479C/TC = 0.003C = 0.0020.8650.43C
T = 0.997T = 0.998
28039773836771104517T/GT = 0.007T = 0.0020.7180.31T
G = 0.993G = 0.998
101399093847671104626C/TC = 0.001C = 0.0010.9940.94C
T = 0.999T = 0.999
7229453851071104660G/AG = 0.751G = 0.7810.2831.18A
A = 0.249A = 0.219
9170693939671105546A/GA = 0.809A = 0.8190.6931.07G
G = 0.191G = 0.181
28039783970371105853C/AC = 0.004C = 0.0020.8690.56C
A = 0.996A = 0.998
23328903980171105951A/GA = 0.001A = 0.0020.962.01G
G = 0.999G = 0.998
19896384007871106228T/CT = 0.333T = 0.3030.3090.87T
C = 0.667C = 0.697
106791744026071106410GGG/—GGG = 0.195GGG = 0.1730.3730.86GGG
— = 0.805— = 0.827
25269154051371106663C/TC = 0.364C = 0.3430.4980.91C
T = 0.636T = 0.657
25269144088971107039T/CT = 0.106T = 0.0380.0002870.33T
C = 0.894C = 0.962
111589644109171107241G/AG = 1.000G = 1.0001
A = 0A = 0
111589654187271108022A/GA = 0.999A = 0.9990.9621.26G
G = 0.001G = 0.001
7400814211271108262A/GA = 0.468A = 0.4410.4050.90A
G = 0.532G = 0.559
7400804229271108442T/GT = 1.000T = 1.0000.976G
G = 0.000G = 0
101405824237371108523T/CT = 0.001T = 00.9310.00T
C = 0.999C = 1.000
25269134487771111027A/GA = 0.192A = 0.1280.01860.62A
G = 0.808G = 0.872
48994374512471111274C/GC = 0.649C = 0.6210.3760.89C
G = 0.351G = 0.379
101456784583171111981T/CT = 0.998T = 0.9960.7380.42T
C = 0.002C = 0.004
21076864603071112180T/CT = 0.001T = 0.0020.9571.97C
C = 0.999C = 0.998
21076854627071112420T/CT = 0.985T = 0.9980.3387.09C
C = 0.015C = 0.002
21076844630971112459G/AG = 0.678G = 0.6370.1760.84G
A = 0.322A = 0.363
71541884654571112695C/GC = 1.000C = 0.9940.80.00C
G = 0G = 0.006
49030414716271113312C/TC = 0.655C = 0.6020.0990.80C
T = 0.345T = 0.398
71596374726771113417T/CT = 0.004T = 0.0050.8751.54C
C = 0.996C = 0.995
65740894907771115227A/GA = 1.000A = 0.9990.9120.15A
G = 0.000G = 0.001
125897534937771115527A/GA = 0A = 0.0010.935G
G = 1.000G = 0.999
48994385012671116276G/CG = 0.001G = 0.0010.9830.73G
C = 0.999C = 0.999
49030425038571116535G/TG = 1.000G = 1.0000.9366.18T
T = 0.000T = 0.000
49030435040371116553A/TA = 0.001A = 00.9770.00A
T = 0.999T = 1.000
28039805042271116572G/AG = 0.478G = 0.5110.2951.14A
A = 0.522A = 0.489
104838485089371117043T/AT = 0.001T = 0.0010.9960.95T
A = 0.999A = 0.999
22403445203171118181G/CG = 0.664G = 0.6360.3640.88G
C = 0.336C = 0.364
22860685224571118395A/GA = 0.639A = 0.6180.520.92A
G = 0.361G = 0.382
113396695259471118744—/G— = 0.001— = 00.9440.00—
G = 0.999G = 1.000
38545287471119024A/GA = 0.619A = 0.5770.2120.84A
G = 0.381G = 0.423
114635301171119161T/GT = 0.59T = 0.5910.9631.01G
G = 0.410G = 0.409
13835365671119806A/TA = 0.863A = 0.8290.150.77A
T = 0.137T = 0.171
13815366271119812C/GC = 0.001C = 0.0010.9660.18C
G = 0.999G = 0.999
13775371171119861T/CT = 1.000T = 1.0000.9930.91T
C = 0.000C = 0.000
111589665379871119948A/GA = 0A = 0.0010.963G
G = 1.000G = 0.999
111589675384071119990A/GA = 0A = 0.0010.963G
G = 1.000G = 0.999
111589685387371120023C/TC = 1.000C = 1.0000.9680.00C
T = 0T = 0.000
111589695388471120034A/GA = 0A = 0.0010.936G
G = 1.000G = 0.999
111589705393771120087A/GA = 0A = 0.0010.979G
G = 1.000G = 0.999
111589715403271120182G/AG = 1.000G = 0.9990.9040.49G
A = 0.000A = 0.001
118497825435271120502C/GC = 0.503C = 0.5270.4461.10G
G = 0.497G = 0.473
101376165543071121580C/TC = 0.46C = 0.4730.6971.05T
T = 0.540T = 0.527
7575725592071122070G/AG = 0.614G = 0.5790.270.87G
A = 0.386A = 0.421
101405665608171122231G/TG = 0.493G = 0.5170.4641.10T
T = 0.507T = 0.483
20234805622771122377A/TA = 0.984A = 0.9990.28213.67T
T = 0.016T = 0.001
25269115735071123500T/AT = 0.029T = 0.0080.3220.27T
A = 0.971A = 0.992
49030445749371123643C/TC = 0.603C = 0.5660.2390.86C
T = 0.397T = 0.434
118451625768271123832G/CG = 1.000G = 1.0001
C = 0C = 0
121472105809271124242C/TC = 1.000C = 0.9960.7710.18C
T = 0.000T = 0.004
29976435873171124881G/TG = 1.000G = 1.0000.9460.00G
T = 0T = 0.000
29976445882671124976A/TA = 1.000A = 1.0000.9920.47A
T = 0.000T = 0.000
38148676091671127066T/CT = 0.999T = 0.9990.9820.82T
C = 0.001C = 0.001
22860676204771128197A/GA = 0.999A = 1.0000.9512.09G
G = 0.001G = 0.000
10605706208071128230T/GT = 0.469T = 0.4940.4141.11G
G = 0.531G = 0.506
23328916266571128815C/GC = 1.000C = 1.0000.9971.14G
G = 0.000G = 0.000
20217366280971128959G/AG = 0.995G = 0.9940.8970.81G
A = 0.005A = 0.006
71608306362971129779T/CT = 0.518T = 0.5420.4611.10C
C = 0.482C = 0.458
25269096543271131582A/GA = 0.998A = 1.0000.8235.46G
G = 0.002G = 0.000
71409636559071131740G/CG = 1.000G = 1.0000.9592.57C
C = 0.000C = 0.000
101436676587671132026A/GA = 0.058A = 0.0530.8230.91A
G = 0.942G = 0.947
28039816711871133268T/CT = 0.685T = 0.6860.961.01C
C = 0.315C = 0.314
7688406734871133498T/CT = 0.964T = 0.9580.790.86T
C = 0.036C = 0.042
58095876823071134380T/—T = 0.724T = 0.690.2450.85T
— = 0.276— = 0.310
20234796826271134412A/GA = 0.001A = 0.0010.9980.94A
G = 0.999G = 0.999
49030456891271135062T/CT = 0.464T = 0.4920.3951.12C
C = 0.536C = 0.508
49030466979971135949A/GA = 0.811A = 0.8250.5831.10G
G = 0.189G = 0.175
58095887002771136177—/G— = 0.001— = 0.0010.9710.57—
G = 0.999G = 0.999
102205557333571139485G/AG = 0.673G = 0.6350.210.85G
A = 0.327A = 0.365
29061327409371140243G/AG = 0.542G = 0.5130.3560.89G
A = 0.458A = 0.487
118484827411471140264T/GT = 1.000T = 1.0001
G = 0G = 0
101299547459271140742T/CT = 0.499T = 0.5380.2271.17C
C = 0.501C = 0.462
25269217506171141211C/TC = 0.027C = 0.0020.01580.05C
T = 0.973T = 0.998
49030477568371141833G/TG = 0.48G = 0.4930.7081.05T
T = 0.520T = 0.507
118463577585771142007A/GA = 1.000A = 0.9990.910.31A
G = 0.000G = 0.001
101363857645771142607G/CG = 0.515G = 0.5330.5831.07C
C = 0.485C = 0.467
125882427713071143280T/AT = 0.001T = 0.0010.9780.61T
A = 0.999A = 0.999
116215177794771144097C/TC = 0C = 0.0020.912T
T = 1.000T = 0.998
25269107833871144488C/TC = 0.622C = 0.5980.4430.90C
T = 0.378T = 0.402
25269417962671145776A/GA = 0.982A = 0.9960.2764.02G
G = 0.018G = 0.004
28039448049771146647G/AG = 0.615G = 0.5750.2270.85G
A = 0.385A = 0.425
124367708057871146728A/GA = 0.033A = 0.0310.9080.93A
G = 0.967G = 0.969
102202798117171147321C/AC = 0.744C = 0.6780.06710.720
A = 0.256A = 0.322
102202808124371147393G/CG = 0.001G = 0.0030.8334.04C
C = 0.999C = 0.997
118441128132171147471A/CA = 0.001A = 0.0020.9242.920
C = 0.999C = 0.998
124324558263471148784G/CG = 0.57G = 0.5750.8771.020
C = 0.430C = 0.425
80153388326971149419G/AG = 1.000G = 0.9990.8910.00G
A = 0A = 0.001
38329698351471149664CAGC/—CAGC = 0.003CAGC = 0.0040.9651.12—
— = 0.997— = 0.996
96719728536771151517A/GA = 1.000A = 1.0000.9740.49A
G = 0.000G = 0.000
96719758542371151573C/TC = 0.998C = 0.9980.951.37T
T = 0.002T = 0.002
71599868600671152156T/CT = 0.166T = 0.1040.007740.58T
C = 0.834C = 0.896
118482208651571152665T/GT = 1.000T = 1.0000.9780.00T
G = 0G = 0.000
50163698693671153086G/CG = 0G = 0.0010.99C
C = 1.000C = 0.999
19864238720171153351A/GA = 0.999A = 0.9990.9640.79A
G = 0.001G = 0.001
23329098720571153355C/TC = 0.573C = 0.5130.130.78C
T = 0.427T = 0.487
80133378831371154463G/AG = 0.62G = 0.5760.1480.83G
A = 0.380A = 0.424
114456808947771155627—/G— = 0.001— = 0.0010.9690.32—
G = 0.999G = 0.999
49030489024371156393T/CT = 0.821T =
C = 0.179C =
124347939073571156885T/CT = 0.688T = 0.6510.2230.85T
C = 0.312C = 0.349
23329109199071158140G/CG = 0.003G = 0.0020.8930.49G
C = 0.997C = 0.998
44100179287971159029A/GA = 0.003A = 0.0010.8720.33A
G = 0.997G = 0.999
45770199288071159030A/GA = 1.000A = 0.9990.9170.00A
G = 0G = 0.001
23329119338671159536A/GA = 0.996A = 0.9950.970.90A
G = 0.004G = 0.005
49967479339771159547T/GT = 0.999T = 0.9990.9840.84T
G = 0.001G = 0.001
101408209368071159830G/TG = 0.002G = 0.0010.940.46G
T = 0.998T = 0.999
124316239558571161735T/CT = 0.995T = 0.9950.9761.05C
C = 0.005C = 0.005
65740909581871161968G/TG = 0.001G = 0.0010.9662.92T
T = 0.999T = 0.999
80087509620371162353C/GC = 0.576C = 0.5790.921.01G
G = 0.424G = 0.421
116274209691171163061G/AG = 0.986G = 0.9880.8781.14A
A = 0.014A = 0.012
101501859801471164164A/GA = 0.934A = 0.9310.8770.96A
G = 0.066G = 0.069
101502189822971164379A/CA = 0.724A = 0.7230.9931.00A
C = 0.276C = 0.277
96461649823571164385T/GT = 0.797T = 0.7720.3510.86T
G = 0.203G = 0.228
65740919917371165323C/TC = 0.995C = 0.9990.6523.38T
T = 0.005T = 0.001
233291210050571166655A/GA = 0A = 0.0010.941G
G = 1.000G = 0.999
715535910161371167763A/GA = 0.558A = 0.580.4971.09G
G = 0.442G = 0.420
233291310166071167810C/TC = 0.094C = 0.10.7781.06T
T = 0.906T = 0.900
454418410168171167831G/TG = 0.001G = 0.0010.9762.43T
T = 0.999T = 0.999
433722410216571168315G/AG = 0.999G = 0.9990.9330.63G
A = 0.001A = 0.001
233291410376371169913C/TC = 0.914C = 0.9040.6270.88C
T = 0.086T = 0.096
428016710499071171140G/AG = 1.000G = 1.0000.9530.00G
A = 0A = 0.000
490304910531971171469G/TG = 1.000G = 1.0000.990.00G
T = 0T = 0.000
374283710544771171597T/GT = 0.873T = 0.8810.721.08G
G = 0.127G = 0.119
1013993710547171171621A/GA = 0.927A = 0.9540.1161.63G
G = 0.073G = 0.046
1243429210551571171665A/GA = 1.000A = 1.0000.9780.00A
G = 0G = 0.000
1162067110559871171748A/TA = 0.001A = 0.0020.9077.24T
T = 0.999T = 0.998
1014018410567471171824C/AC = 0.488C = 0.5450.07311.26A
A = 0.512A = 0.455
233291510643271172582C/GC = 0.45C = 0.4610.7491.04G
G = 0.550G = 0.539
233291610698871173138C/TC = 0.245C = 0.190.03730.72C
T = 0.755T = 0.810
801275910707671173226C/TC = 0.603C = 0.5750.370.89C
T = 0.397T = 0.425
1014927210799171174141G/CG = 0.701G = 0.6820.5090.91G
C = 0.299C = 0.318
1115897310822171174371A/GA = 0.767A = 0.7670.9831.00G
G = 0.233G = 0.233
490305010841071174560G/TG = 0.494G = 0.5130.6271.08T
T = 0.506T = 0.487
1066644510876271174912CTTA/—CTTA =CTTA = 0.19
— = 0.810
253614310892471175074A/TA = 0.939A = 0.9040.1540.61A
T = 0.061T = 0.096
1063823110937871175528TTTTTTTTTTTTTTTTTTTTTTTTT0.9091.06—
TTTTTT/—TTTT = 0.923TTTT = 0.927
— = 0.077— = 0.073
1243163610944271175592A/GA = 0.219A = 0.2180.9640.99A
G = 0.781G = 0.782
800590410961971175769C/TC =C = 0.002
T =T = 0.998
1162105810982071175970C/TC = 0.881C = 0.8630.4170.85C
T = 0.119T = 0.137
1013322411053071176680T/CT = 0T = 01
C = 1.000C = 1.000
1243318511095671177106A/TA = 0.692A = 0.6790.6740.94A
T = 0.308T = 0.321
74097411196571178115A/GA = 0.764A = 0.7540.7170.95A
G = 0.236G = 0.246
74097311199571178145G/CG = 0.435G = 0.4680.3151.14C
C = 0.565C = 0.532
74097211204071178190T/CT = 0.637T = 0.6490.711.05C
C = 0.363C = 0.351
74097111205871178208A/GA = 0.978A = 0.9770.9620.97A
G = 0.022G = 0.023
424364211259271178742C/GC = 0.573C = 0.5740.9871.00G
G = 0.427G = 0.426
441595211304471179194C/TC = 0.654C = 0.6480.8390.97C
T = 0.346T = 0.352
221558911326371179413G/AG = 0.999G = 0.9980.9090.60G
A = 0.001A = 0.002
434321111330171179451T/CT = 0T = 0.0010.984C
C = 1.000C = 0.999
253614211351371179663T/CT = 0.87T = 0.860.6820.92T
C = 0.130C = 0.140
1129334011363971179789—/A— = 0.002— = 0.0020.9950.97—
A = 0.998A = 0.998
1015162011409271180242C/GC = 0.625C = 0.6150.7570.96C
G = 0.375G = 0.385
228684011443271180582T/GT = 0.999T = 0.9980.9430.66T
G = 0.001G = 0.002
802308911464371180793T/AT = 0T =
A = 1.000A =
800800911498071181130G/AG = 0.616G = 0.6280.6931.05A
A = 0.384A = 0.372
1141908911531271181462—/T— = 0.755— = 0.7430.6610.93—
T = 0.245T = 0.257
1069467611531571181465—/TT— = 0.938— = 0.9270.5810.84—
TT = 0.062TT = 0.073
253614111537771181527C/TC = 0.884C = 0.8780.780.94C
T = 0.116T = 0.122
76524711562571181775C/AC = 0.978C = 0.9810.9171.13A
A = 0.022A = 0.019
714762611574071181890T/CT = 0.973T = 0.950.1470.53T
C = 0.027C = 0.050
1013262911574771181897G/AG = 0.649G = 0.6560.7991.03A
A = 0.351A = 0.344
490305111589071182040C/GC = 0.976C = 0.9650.5410.68C
G = 0.024G = 0.035
1115897411727971183429T/CT = 0.976T = 0.9610.2410.60T
C = 0.024C = 0.039
103502111752271183672C/AC = 0.513C = 0.5090.9090.99C
A = 0.487A = 0.491
657409311872171184871T/GT = 0.433T = 0.4450.7211.05G
G = 0.567G = 0.555
489943911992671186076T/CT = 0.973T = 0.9580.350.65T
C = 0.027C = 0.042
715528711997471186124T/AT = 1.000T = 0.9990.8350.17T
A = 0.000A = 0.001
715440212028171186431A/GA = 0.972A = 0.9480.1580.53A
G = 0.028G = 0.052
715478112048471186634G/AG = 0.971G = 0.9560.3150.65G
A = 0.029A = 0.044
657409412239771188547C/TC = 0.972C = 0.9480.08510.52C
T = 0.028T = 0.052
1013224212278371188933G/AG = 0.975G = 0.9460.04360.46G
A = 0.025A = 0.054
1014695912302971189179T/CT = 0.694T = 0.6980.8751.02C
C = 0.306C = 0.302
1014746612353571189685T/CT = 1.000T = 1.0000.950.00T
C = 0C = 0.000
1162641112410771190257G/CG = 0.757G = 0.7740.5391.10C
C = 0.243C = 0.226
489944012442771190577C/TC = 0.683C = 0.7270.1291.24T
T = 0.317T = 0.273
1014455312473871190888T/CT = 0.539T = 0.5260.6770.95T
C = 0.461C = 0.474
1162766312532971191479A/CA = 0.009A = 0.0780.001369.35C
C = 0.991C = 0.922
1162779912579671191946A/GA = 0.669A = 0.6680.9590.99A
G = 0.331G = 0.332
1185173312626571192415G/AG = 0.65G = 0.6650.6311.07A
A = 0.350A = 0.335
1014031712676871192918A/TA = 0.476A = 0.4550.5140.92A
T = 0.524T = 0.545
800737512730671193456C/TC = 0.001C = 0.0010.9373.61T
T = 0.999T = 0.999
489944112754471193694G/AG = 0.043G = 0.0940.002982.32A
A = 0.957A = 0.906
1115897512780971193959A/CA = 0.798A = 0.8140.5641.11C
C = 0.202C = 0.186
1141960712781771193967A/—A = 0.829A = 0.8080.4060.86A
— = 0.171— = 0.192
210979312977171195921C/GC =C = 0.997
G =G = 0.003
802315613006171196211G/CG = 0.706G = 0.7060.9871.00C
C = 0.294C = 0.294
1014057913033371196483G/AG = 0.002G = 0.0010.9840.86G
A = 0.998A = 0.999
714819913173471197884T/CT = 0.078T = 0.1190.04811.61C
C = 0.922C = 0.881
714691613178771197937G/AG = 0.001G = 0.0020.82354.34A
A = 0.999A = 0.998
199043913263371198783G/AG = 0.67G = 0.720.1031.27A
A = 0.330A = 0.280
657409513527971201429C/GC = 0.057C = 0.0930.05851.71G
G = 0.943G = 0.907
1014003713570971201859T/AT = 0.456T = 0.4380.5690.93T
A = 0.544A = 0.562
800724913620871202358A/GA = 0.81A = 0.7910.5120.89A
G = 0.190G = 0.209
199043813709171203241A/GA = 0.902A = 0.8590.070.66A
G = 0.098G = 0.141
199043713749971203649T/CT = 0.092T = 0.1550.003671.82C
C = 0.908C = 0.845
1014648413770571203855A/GA = 0.69A = 0.6790.7190.95A
G = 0.310G = 0.321
1162733313772671203876A/CA = 0.336A = 0.3250.7160.95A
C = 0.664C = 0.675
715580213794471204094G/AG = 0.012G = 0.0070.7460.55G
A = 0.988A = 0.993
210979213817571204325T/GT = 0T = 01
G = 1.000G = 1.000
1142936313822471204374A—A = 0.24A = 0.2620.4551.13—
— = 0.760— = 0.738
800421013931971205469A/GA = 0.94A = 0.8870.008780.50A
G = 0.060G = 0.113
209819413940971205559C/TC = 1.000C = 0.9990.9220.54C
T = 0.000T = 0.001
210979113959771205747T/GT = 0.753T = 0.7240.3150.86T
G = 0.247G = 0.276
1138172914047671206626—/A— = 0.45— = 0.4920.181.18A
A = 0.550A = 0.508
116009414080871206958C/TC = 0.731C = 0.7510.5141.11T
T = 0.269T = 0.249
1162805114136371207513A/TA = 0.386A = 0.3280.05550.77A
T = 0.614T = 0.672
1013677114165571207805G/AG = 0.341G = 0.380.2351.18A
A = 0.659A = 0.620
1013990314271571208865A/CA = 0.592A = 0.5470.1450.83A
C = 0.408C = 0.453
490305314325371209403C/TC = 0.74C = 0.7680.3271.16T
T = 0.260T = 0.232
374283614391171210061T/CT = 0.752T = 0.7760.391.14C
C = 0.248C = 0.224
374283514404471210194G/AG = 0.311G = 0.3110.9991.00G
A = 0.689A = 0.689
800323314467071210820T/GT = 0.002T = 0.0020.9710.78T
G = 0.998G = 0.998
1162158814496171211111C/TC = 0.999C = 1.0000.9132.87T
T = 0.001T = 0.000
74098114661371212763G/CG = 0.468G = 0.4250.1870.84G
C = 0.532C = 0.575
801949214741371213563C/AC = 0.001C = 0.0020.8822.59A
A = 0.999A = 0.998
801964414746471213614G/AG = 0.001G = 0.0020.8992.47A
A = 0.999A = 0.998
801964614746871213618G/AG = 0.541G = 0.5690.4221.12A
A = 0.459A = 0.431
801965314747971213629A/GA = 0.581A = 0.650.03221.34G
G = 0.419G = 0.350
1145079414748871213638A/—A = 0.002A = 0.0010.9460.50A
— = 0.998— = 0.999
1134819314750071213650—/A— = 0.67— = 0.6360.2770.86—
A = 0.330A = 0.364
1145079314752771213677G/—G = 0.007G = 0.0050.8940.77G
— = 0.993— = 0.995
1128273514753471213684AAGAGAAGAGAAGAG0.9110.59AAGAG
AAGAG/—AAGAG = 0.004AAGAG = 0.003AAGAG
— = 0.996— = 0.997
219182314957371215723G/TG = 0.504G = 0.4670.2420.86G
T = 0.496T = 0.533
1223222015079871216948A/GA = 0.143A = 0.2350.0003831.85G
G = 0.857G = 0.765
1115897615416971220319C/TC = 0.747C = 0.7910.1111.28T
T = 0.253T = 0.209
490305415505671221206C/TC = 1.000C = 0.9990.940.53C
T = 0.000T = 0.001
1184675515549471221644T/CT = 0.703T = 0.7040.9881.00C
C = 0.297C = 0.296
1243198815775671223906G/AG = 0.547G = 0.5570.7541.04A
A = 0.453A = 0.443
1210052615783071223980T/CT = 0.001T = 0.0020.971.30C
C = 0.999C = 0.998
1162256815837971224529A/CA = 0.476A = 0.4420.2790.87A
C = 0.524C = 0.558
967123015990671226056C/TC = 0.001C = 0.0010.961.81T
T = 0.999T = 0.999
1214748715995171226101A/TA = 0.596A = 0.6160.5271.09T
T = 0.404T = 0.384
490305516013571226285T/CT = 0.879T = 0.8760.8850.97T
C = 0.121C = 0.124
1214751516020971226359G/AG = 0.955G = 0.9540.9580.98G
A = 0.045A = 0.046
1162509216035171226501C/TC = 0.999C = 0.9990.9720.84C
T = 0.001T = 0.001
489944216083571226985T/GT = 0.042T = 0.0880.01242.21G
G = 0.958G = 0.912
205214616111071227260A/CA = 0.977A = 0.9570.1450.53A
C = 0.023C = 0.043
1022055316134671227496A/TA = 0.438A = 0.450.7141.05T
T = 0.562T = 0.550
1022056516167071227820A/GA =A = 0.159
G =G = 0.841
233291716344771229597G/CG = 0.045G = 0.0130.01750.27G
C = 0.955C = 0.987
715891016347971229629G/AG = 1.000G = 1.0000.9880.00G
A = 0A = 0.000
801574916437771230527A/GA = 0.203A = 0.3030.006031.70G
G = 0.797G = 0.697
800681216632871232478A/GA = 0.999A = 0.9990.9691.34G
G = 0.001G = 0.001
800833816636171232511C/TC = 0.002C = 0.0030.9111.49T
T = 0.998T = 0.997
205214516700371233153T/GT = 0.142T = 0.1990.1171.50G
G = 0.858G = 0.801
205214416703671233186T/GT = 0.243T = 0.2230.5950.89T
G = 0.757G = 0.777
1014669216775971233909A/GA = 0.492A = 0.4720.5530.93A
G = 0.508G = 0.528
1162730516782971233979A/GA = 0.831A = 0.8360.8281.04G
G = 0.169G = 0.164
207998916836071234510C/TC = 0.466C = 0.4440.4910.92C
T = 0.534T = 0.556
801888116858271234732C/AC = 0.998C = 0.9940.7380.33C
A = 0.002A = 0.006
456138716946271235612A/TA = 0.894A = 0.8920.9210.98A
T = 0.106T = 0.108
1162202517031771236467A/CA = 0.26A = 0.2410.4980.90A
C = 0.740C = 0.759
74098017066971236819A/GA = 0.378A = 0.3540.4980.90A
G = 0.622G = 0.646
1243325017129571237445T/CT = 0.285T = 0.2580.360.87T
C = 0.715C = 0.742
580959017139571237545—/A— = 0.249— = 0.2660.5541.09A
A = 0.751A = 0.734
75891517143171237581T/CT = 0.28T = 0.2810.9881.00C
C = 0.720C = 0.719
75891417162671237776A/TA = 0.249A = 0.2490.9981.00T
T = 0.751T = 0.751
715422917173571237885G/AG = 1.000G = 0.9990.9010.17G
A = 0.000A = 0.001
1243718817197271238122T/CT = 0.894T = 0.9480.002792.15C
C = 0.106C = 0.052
715910817225871238408T/AT = 0.739T = 0.7460.8021.04A
A = 0.261A = 0.254
490305817244871238598G/CG = 1.000G = 1.0000.993C
C = 0.000C = 0
489944317291871239068C/AC = 0.775C = 0.8060.2641.21A
A = 0.225A = 0.194
1184890717341571239565A/GA = 0.037A = 0.0320.7040.85A
G = 0.963G = 0.968
1243214817346771239617G/TG = 0.201G = 0.110.0003190.49G
T = 0.799T = 0.890
1243507817369771239847C/tC = 0.912C = 0.9050.8230.92C
T = 0.088T = 0.095
657409617399171240141A/GA = 0.461A = 0.4110.1220.82A
G = 0.539G = 0.589
1115897717409171240241T/AT = 0.4T = 0.4350.2591.16A
A = 0.600A = 0.565
1162943417457171240721G/TG = 0.841G = 0.8420.9741.01T
T = 0.159T = 0.158
437856317778071243930C/TC = 0.863C = 0.9320.001022.16T
T = 0.137T = 0.068
209819517812971244279C/GC = 0.032C = 0.030.9060.95C
G = 0.968G = 0.970
463365317869371244843C/AC = 0.998C = 0.9980.9311.34A
A = 0.002A = 0.002
714835017932571245475G/AG = 0.962G = 0.9530.5350.80G
A = 0.038A = 0.047
74097917951171245661A/TA = 0.34A = 0.310.360.87A
T = 0.660T = 0.690
74097817960871245758G/CG = 0.983G = 0.9530.020.35G
C = 0.017C = 0.047
74097717964471245794A/GA = 0.086A = 0.1290.05121.57G
G = 0.914G = 0.871
74097617980871245958T/CT = 0.39T = 0.3230.03530.74T
C = 0.610C = 0.677
490305918004171246191C/TC = 0.138C = 0.0830.006740.56C
T = 0.862T = 0.917
490306018142071247570G/AG = 0.995G = 0.960.003270.13G
A = 0.005A = 0.040
1185205618142371247573A/GA = 0.001A = 0.0010.9991.03G
G = 0.999G = 0.999
963525718193271248082C/TC = 0.947C = 0.9540.7221.17T
T = 0.053T = 0.046
963525818199271248142C/TC = 0.93C = 0.9350.831.09T
T = 0.070T = 0.065
963525918224871248398A/GA = 0.896A = 0.9420.01421.88G
G = 0.104G = 0.058
489944418233571248485G/AG = 0.868G = 0.8870.4181.19A
A = 0.132A = 0.113
1243538218426871250418G/AG = 0.777G = 0.790.6141.08A
A = 0.223A = 0.210
1243541218436671250516G/AG = 0.831G = 0.8280.8830.98G
A = 0.169A = 0.172
1162738118485571251005G/AG = 0.178G = 0.1770.9550.99G
A = 0.822A = 0.823
205214318553271251682G/AG = 0.537G = 0.5930.0721.26A
A = 0.463A = 0.407
205214218563371251783G/AG = 0.98G = 0.950.02550.39G
A = 0.020A = 0.050
205214118571771251867C/TC = 0.641C = 0.6860.1341.22T
T = 0.359T = 0.314
802103518663771252787A/GA = 0.001A = 0.0020.9551.61G
G = 0.999G = 0.998
1115897818701071253160A/GA = 0.402A = 0.3870.6660.94A
G = 0.598G = 0.613
1162121618736771253517A/TA = 0.882A = 0.8820.9790.99A
T = 0.118T = 0.118
1013087318752471253674T/CT = 0.901T = 0.9360.06161.60C
C = 0.099C = 0.064
1162135818752571253675G/AG = 0.864G = 0.8670.8631.03A
A = 0.136A = 0.133
75891318835271254502A/GA = 0.071A = 0.1330.007892.00G
G = 0.929G = 0.867
1162260218836071254510A/GA = 0.241A = 0.2180.4020.88A
G = 0.759G = 0.782
1013693118903271255182C/TC = 1.000C = 1.0000.9690.00C
T = 0T = 0.000
74097518910071255250T/GT = 0.543T = 0.4890.1160.80T
G = 0.457G = 0.511
74798718944471255594T/CT = 0.291T = 0.1860.0001340.56T
C = 0.709C = 0.814
1162381918945071255600C/TC = 0.736C = 0.7030.2850.85C
T = 0.264T = 0.297
1243444519043171256581C/AC = 0.003C = 0.0010.880.44C
A = 0.997A = 0.999
800337519081371256963T/AT = 0.001T = 0.0010.9951.58A
A = 0.999A = 0.999
1014359619098371257133A/GA = 0.997A = 0.9960.9250.75A
G = 0.003G = 0.004
1243532119149371257643T/CT = 0.164T = 0.1630.9680.99T
C = 0.836C = 0.837
1243540119158871257738A/GA =A = 0.302
G =G = 0.698
801060919176471257914T/CT = 1.000T = 0.9990.9150.43T
C = 0.000C = 0.001
1115897919181171257961G/CG = 0.291G = 0.2840.8220.97G
C = 0.709C = 0.716
1115898019212671258276C/TC = 0.271C = 0.2430.3240.87C
T = 0.729T = 0.757
1162752419235671258506C/AC = 0.897C = 0.8920.8280.95C
A = 0.103A = 0.108
112616019295371259103A/CA = 0.657A = 0.5870.07170.74A
C = 0.343C = 0.413
1013607419413371260283G/CG = 0.998G = 0.9930.5640.28G
C = 0.002C = 0.007
490306119533371261483T/AT = 0.372T =
A = 0.628A =
1066539819565771261807—/CA— = 0.538— = 0.5440.8421.03CA
CA = 0.462CA = 0.456
657409719566871261818A/CA = 0.976A = 0.9490.1760.46A
C = 0.024C = 0.051
967165419567671261826C/GC = 0.253C = 0.2350.5380.91C
G = 0.747G = 0.765
1014002419580571261955C/TC = 0.354C = 0.3140.2030.84C
T = 0.646T = 0.686
1014242119599871262148G/AG = 0.97G = 0.9730.8321.10A
A = 0.030A = 0.027
1014259319606671262216C/TC = 0.023C = 0.0570.05092.57T
T = 0.977T = 0.943
1142337219641571262565—/C— = 0.072— = 0.1130.03271.65C
C = 0.928C = 0.887
580959219641771262567—/C— = 0.0680— = 0.1090.04421.68C
C = 0.932C = 0.891
233291819653871262688C/TC = 0.953C = 0.930.1690.65C
T = 0.047T = 0.070
233291919656971262719T/CT = 0.704T = 0.7280.3881.13C
C = 0.296C = 0.272
800734819662171262771A/CA = 0.417A = 0.340.01610.72A
C = 0.583C = 0.660
199044319680671262956G/AG = 0.678G = 0.7290.07511.28A
A = 0.322A = 0.271
800769019682371262973C/GC = 0.175C = 0.1690.8290.96C
G = 0.825G = 0.831
393745519720471263354G/CG = 0.556G = 0.5460.7680.96G
C = 0.444C = 0.454
801282319743571263585C/TC = 0.65C = 0.6510.971.00T
T = 0.350T = 0.349
489944519761271263762G/AG = 0.129G = 0.06300.0008360.45G
A = 0.871A = 0.937
490306219785471264004C/TC = 0.229C = 0.1185.96E−060.45C
T = 0.771T = 0.882
97396319826471264414G/AG = 0.968G = 0.9640.7360.87G
A = 0.032A = 0.036
1014996219883571264985T/GT = 0.963T = 0.9490.3210.71T
G = 0.037G = 0.051
800344919927571265425A/GA = 0.39A = 0.3680.5760.91A
G = 0.610G = 0.632
1162077519933671265486C/TC = 0.827C = 0.8090.4760.88C
T = 0.173T = 0.191
800908919990371266053A/GA = 0.848A = 0.8760.2171.27G
G = 0.152G = 0.124
800896720001771266167T/CT = 0.358T = 0.4060.1361.23C
C = 0.642C = 0.594
1205013220014171266291A/TA = 0.782A = 0.7610.5090.89A
T = 0.218T = 0.239
1013301820055271266702T/CT = 0.999T = 0.9930.5110.20T
C = 0.001C = 0.007
199044220086871267018T/CT =T = 0.926
C =C = 0.074
199044120098371267133T/GT = 0.873T = 0.8480.3380.81T
G = 0.127G = 0.152
801583320099071267140C/TC = 0.768C = 0.790.4231.14T
T = 0.232T = 0.210
199044020104571267195G/CG = 0.258G = 0.1610.0002970.55G
C = 0.742C = 0.839
490306320242671268576C/GC = 0.989C = 0.9690.1880.35C
G = 0.011G = 0.031
1013981020284171268991C/AC = 0.002C = 0.0060.743.78A
A = 0.998A = 0.994
490306420331171269461T/CT = 0.83T = 0.8230.7830.95T
C = 0.170C = 0.177
215971520354371269693A/CA = 0.468A = 0.4580.7480.96A
C = 0.532C = 0.542
210979520374971269899A/GA = 0.206A = 0.2550.1061.32G
G = 0.794G = 0.745
215971420404071270190G/AG = 0.965G = 0.960.7140.87G
A = 0.035A = 0.040
1162310720426971270419A/CA = 0.001A = 0.0020.8835.49C
C = 0.999C = 0.998
715200520430971270459C/TC = 0.806C = 0.7760.2950.84C
T = 0.194T = 0.224
715248920442671270576A/GA = 0.004A = 0.0020.9190.65A
G = 0.996G = 0.998
447916720513571271285G/CG = 0.169G = 0.2780.0001231.90C
C = 0.831C = 0.722
460665520526971271419T/CT = 0.794T = 0.7340.0410.72T
C = 0.206C = 0.266
460665620532371271473T/CT = 0.938T = 0.8720.00320.45T
C = 0.062C = 0.128
448994320536471271514A/GA = 0.546A = 0.4270.000250.62A
G = 0.454G = 0.573
714264220631071272460G/CG = 0.616G = 0.6010.6430.94G
C = 0.384C = 0.399
800623320660071272750A/GA = 0.814A =
G = 0.186G =
800755920678671272936T/AT = 0.426T = 0.5526.35E−051.66A
A = 0.574A = 0.448
800615620679671272946A/GA = 0.456A = 0.5830.0004591.67G
G = 0.544G = 0.417
146866220763371273783A/GA = 0.961A = 0.9320.06740.56A
G = 0.039G = 0.068
1162704820772371273873G/AG = 0.791G = 0.7810.7140.94G
A = 0.209A = 0.219
657409820802671274176T/CT = 0.122T = 0.1520.1991.29C
C = 0.878C = 0.848
1243376020862771274777C/TC = 0.695C = 0.6680.4620.88C
T = 0.305T = 0.332
1243378020866271274812C/TC = 0.102C = 0.0720.1070.68C
T = 0.898T = 0.928
1243450620910971275259T/AT = 0.906T = 0.9460.06111.81A
A = 0.094A = 0.054
1243467320974271275892T/CT = 0.976T = 0.9980.050810.27C
C = 0.024C = 0.002
1243140020975071275900T/CT = 0.335T = 0.2330.000480.60T
C = 0.665C = 0.767
1243138420981771275967G/AG = 0.173G = 0.1010.001470.54G
A = 0.827A = 0.899
490306721019171276341C/TC = 0.449C = 0.4080.1920.85C
T = 0.551T = 0.592
233292021034971276499G/AG = 0.57G =
A = 0.430A =
221559121072471276874A/GA = 0.111A = 0.1460.1431.36G
G = 0.889G = 0.854
1243306421153771277687C/AC = 0.95C = 0.9520.8671.06A
A = 0.050A = 0.048
1243626321155171277701T/GT = 0.973T = 0.9940.24.13G
G = 0.027G = 0.006
1243309721165971277809G/AG = 0.202G = 0.1180.001840.53G
A = 0.798A = 0.882
1243318421175771277907G/TG = 0.854G = 0.920.00331.96T
T = 0.146T = 0.080
801590021182171277971A/TA = 0.004A = 0.0030.9070.72A
T = 0.996T = 0.997
1129698121223671278386T/—T = 0.819T = 0.7960.4130.87T
— = 0.181— = 0.204
1134402521223771278387T/—T = 0.817T = 0.7980.5110.89T
— = 0.183— = 0.202
1146420421244271278592—/A— = 1.000— = 1.0000.991.43A
A = 0.000A = 0.000
1144117221244571278595—/T— = 0.281— = 0.2960.5881.08T
T = 0.719T = 0.704
1138180721245571278605T/—T = 0.865T = 0.8440.3390.84T
— = 0.135— = 0.156
1087325121273071278880G/AG = 0.093G = 0.0760.3610.80G
A = 0.907A = 0.924
210979421274671278896T/CT = 0.301T = 0.3170.581.08C
C = 0.699C = 0.683
1087325221283671278986T/CT = 0.809T = 0.7950.6040.92T
C = 0.191C = 0.205
452078421288671279036G/AG = 0G =
A = 1.000A =
287782021302871279178A/TA = 0.005A = 0.0020.70.30A
T = 0.995T = 0.998
287782121302971279179A/TA = 0.222A = 0.1380.0009360.56A
T = 0.778T = 0.862
456919521309571279245C/GC = 0.888C = 0.9440.01162.11G
G = 0.112G = 0.056
1162890521424771280397A/CA = 0.008A = 0.0600.01678.40C
C = 0.992C = 0.940
219182221480771280957T/CT = 0.104T = 0.1620.01171.67C
C = 0.896C = 0.838
219182121492171281071A/CA = 0.574A = 0.5820.7941.04C
C = 0.426C = 0.418
1146468921516371281313T/—T = 0.52T = 0.4840.2540.86T
— = 0.480— = 0.516
1243195921540671281556G/AG = 0.747G = 0.740.820.97G
A = 0.253A = 0.260
490306821606971282219A/GA = 0.457A = 0.4920.2731.15G
G = 0.543G = 0.508
154457921684971282999T/CT = 0.507T = 0.5220.641.06C
C = 0.493C = 0.478
715587921713071283280G/TG = 0.942G = 0.9710.08022.05T
T = 0.058T = 0.029
1243360321714371283293C/GC = 0.898C = 0.9390.02731.75G
G = 0.102G = 0.061
1135143221765771283807A/—A = 0.261A = 0.2870.3871.14—
— = 0.739— = 0.713
1144843821772571283875—/G— = 0.022— = 0.0920.0003094.52G
G = 0.978G = 0.908
424364321843571284585G/AG = 0.617G = 0.5780.2570.85G
A = 0.383A = 0.422
414095221871771284867T/CT = 0.437T = 0.4620.431.11C
C = 0.563C = 0.538
800537221881271284962C/TC = 0C = 0.0010.903T
T = 1.000T = 0.999
800410921882671284976T/CT = 0.002T = 0.0020.9660.77T
C = 0.998C = 0.998
800839821887271285022A/CA = 0.616A = 0.5690.1810.82A
C = 0.384C = 0.431
800969221889071285040T/CT = 0.817T = 0.7440.03530.65T
C = 0.183C = 0.256
233292121894471285094C/GC = 0.999C = 1.0000.9321.94G
G = 0.001G = 0.000
1205032021922971285379A/GA = 0A = 0.0010.949G
G = 1.000G = 0.999
1205032321930071285450A/GA = 0.001A = 0.0010.9670.68A
G = 0.999G = 0.999
801031621975771285907A/GA = 0.62A = 0.6070.7030.95A
G = 0.380G = 0.393
715429322053371286683T/CT = 0.551T = 0.5580.8371.03C
C = 0.449C = 0.442
1214796922153471287684C/TC = 0.857C = 0.8440.6040.90C
T = 0.143T = 0.156
221559022163271287782G/AG = 0.732G = 0.7120.5430.91G
A = 0.268A = 0.288
426574922223471288384C/TC = 0.942C = 0.9920.02637.44T
T = 0.058T = 0.008
100455222224171288391C/TC = 0.605C = 0.6230.5821.08T
T = 0.395T = 0.377
430789222245871288608G/AG = 0.845G = 0.920.0003892.10A
A = 0.155A = 0.080
1243197322273571288885T/GT =T = 1.000
G =G = 0
1243197522274971288899A/GA = 0.808A = 0.7470.03150.70A
G = 0.192G = 0.253
76787422318771289337T/CT = 1.000T = 1.0000.94216.74C
C = 0.000C = 0.000
1162859722662671292776G/CG = 0.799G = 0.8240.3261.18C
C = 0.201C = 0.176
1012937122686571293015A/GA = 0.59A = 0.5320.06550.79A
G = 0.410G = 0.468
490306922754871293698A/CA = 0.928A = 0.9320.8281.06C
C = 0.072C = 0.068
490307022769071293840A/GA = 0.572A = 0.5760.8831.02G
G = 0.428G = 0.424
490307122781571293965G/TG = 0.692G = 0.7520.03641.35T
T = 0.308T = 0.248
1162222422845671294606T/CT = 0.661T = 0.670.7541.04C
C = 0.339C = 0.330
1045945522902571295175G/AG = 0.709G = 0.7050.8790.98G
A = 0.291A = 0.295
932357722908571295235C/TC = 0.654C = 0.5990.1690.79C
T = 0.346T = 0.401
1062464823175771297907TTG/—TTG = 0.998TTG = 0.9850.210.15TTG
— = 0.002— = 0.015
305895323176271297912GTT/—GTT = 0.995GTT = 0.9760.140.22GTT
— = 0.005— = 0.024
1115898123272771298877T/GT = 0.716T = 0.6890.3450.88T
G = 0.284G = 0.311
1115898223295571299105T/GT = 0.399T = 0.4210.4961.09G
G = 0.601G = 0.579
1115898323330271299452G/TG = 0.734G = 0.710.4070.89G
T = 0.266T = 0.290
186075023362971299779T/AT = 0.554T = 0.5910.3091.16A
A = 0.446A = 0.409
186074923367071299820G/AG = 0.347G = 0.4779.51E−051.71A
A = 0.653A = 0.523
186074823370271299852A/CA = 0.108A = 0.1840.002351.86C
C = 0.892C = 0.816
186074723371571299865A/GA = 0.998A = 0.9550.08110.05A
G = 0.002G = 0.045
1141967923582771301977—/A— = 0.597— = 0.5670.360.88—
A = 0.403A = 0.433
801177723695171303101T/CT = 0.993T =
C = 0.007C =
657409923715771303307A/GA = 0.368A = 0.3630.8790.98A
G = 0.632G = 0.637
801095723731771303467A/GA = 0.09A = 0.1990.0001062.53G
G = 0.910G = 0.801
1162689523736371303513G/AG = 0.744G = 0.730.6340.93G
A = 0.256A = 0.270
1015143123886671305016T/GT = 0T = 01
G = 1.000G = 1.000
490307223978971305939C/AC = 0.451C = 0.4620.7471.04A
A = 0.549A = 0.538
458948924017071306320T/CT = 0.001T = 0.0010.9791.61C
C = 0.999C = 0.999
967132724043071306580G/TG = 0.828G = 0.8420.5581.11T
T = 0.172T = 0.158
489944624045471306604C/TC = 0.552C = 0.5740.4971.09T
T = 0.448T = 0.426
1014450124068871306838T/AT = 0.001T = 0.0010.9760.57T
A = 0.999A = 0.999
580959424141471307564TG/—TG = 0.55TG = 0.5330.5930.93TG
— = 0.450— = 0.467
72031724142471307574A/GA = 0.3A = 0.3220.5821.11G
G = 0.700G = 0.678
801431624174171307891G/AG = 0.001G = 0.0010.9332.97A
A = 0.999A = 0.999
1115898424176871307918T/CT = 0.438T = 0.4530.6331.06C
C = 0.562C = 0.547
642090624236071308510C/TC = 0.007C = 0.0480.001057.74T
T = 0.993T = 0.952
800405524295771309107A/TA = 1.000A = 1.0000.9862.23T
T = 0.000T = 0.000
1243480024335571309505A/GA = 0.132A = 0.0690.004280.49A
G = 0.868G = 0.931
424364424359671309746T/AT = 0.609T = 0.5750.3080.87T
A = 0.391A = 0.425
489944724364871309798A/GA = 0.815A = 0.8160.9811.00G
G = 0.185G = 0.184
490307324366471309814G/AG = 0.176G = 0.1760.9991.00A
A = 0.824A = 0.824
1184863424378371309933T/CT = 0.001T = 00.9270.00T
C = 0.999C = 1.000
489944824381971309969T/CT = 0.792T = 0.7690.3960.87T
C = 0.208C = 0.231
1013156424576571311915A/GA = 0.72A = 0.7080.6940.95A
G = 0.280G = 0.292
1013415024608971312239T/GT = 0.713T = 0.6850.3540.88T
G = 0.287G = 0.315
76338824645771312607A/GA = 0.71A = 0.6940.5920.93A
G = 0.290G = 0.306
1184593824648571312635A/GA = 0A = 0.0010.975G
G = 1.000G = 0.999
1184594624653671312686G/TG = 0.999G = 1.0000.9053.40T
T = 0.001T = 0.000
1184591524658671312736T/CT = 0.004T = 0.0020.8370.49T
C = 0.996C = 0.998
1013746324735671313506A/CA = 0.998A = 0.9980.9891.05C
C = 0.002C = 0.002
657410024757371313723T/AT = 0.409T = 0.4180.7671.04A
A = 0.591A = 0.582
714034424817371314323A/GA = 0A = 0.0010.96G
G = 1.000G = 0.999
1064688924891571315065AA/—AA =AA = 0.604
— =— = 0.396
714628724934471315494C/TC = 1.000C = 1.0000.9750.00C
T = 0T = 0.000
580959525057571316725A/—A = 0.406A = 0.3840.5050.91A
— = 0.594— = 0.616
103509925070171316851T/AT = 0.447T = 0.4570.7811.04A
A = 0.553A = 0.543
715987725126071317410T/GT = 0.291T = 0.3290.2111.19G
G = 0.709G = 0.671
714257925185871318008G/AG = 0.037G = 0.0750.02752.10A
A = 0.963A = 0.925
1243176225198171318131G/AG = 0.867G = 0.8710.8551.04A
A = 0.133A = 0.129
1243176425199071318140G/AG = 0.611G = 0.5950.6120.94G
A = 0.389A = 0.405
1064799925232671318476AGAAAAGAAAAGAAA0.9360.99AGAAA
GAAAG/—GAAAG = 0.492GAAAG = 0.489GAAAG
— = 0.508— = 0.511
657410125272771318877C/TC = 0.737C = 0.7070.3130.86C
T = 0.263T = 0.293
657410225294671319096T/CT = 0.747T = 0.7620.5851.09C
C = 0.253C = 0.238
186116225419971320349T/CT = 0.513T = 0.5230.7871.04C
C = 0.487C = 0.477
1243297225498571321135T/CT = 1.000T = 0.9990.9530.58T
C = 0.000C = 0.001
1014613425532471321474A/TA = 0.69A = 0.7060.5981.08T
T = 0.310T = 0.294
1014661625568671321836A/CA = 0.858A = 0.840.4480.87A
C = 0.142C = 0.160
1014676925571871321868A/GA = 0.052A = 0.0810.09331.62G
G = 0.948G = 0.919
801893625632171322471G/AG =G = 0.995
A =A = 0.005
1048384925756271323712G/AG = 0.302G = 0.2910.720.95G
A = 0.698A = 0.709
216013725884371324993T/CT = 0.842T = 0.8110.2420.81T
C = 0.158C = 0.189
219259525888071325030C/AC = 0.861C = 0.8340.4220.81C
A = 0.139A = 0.166
219259425906071325210A/GA = 0.374A = 0.3830.7891.04G
G = 0.626G = 0.617
1127169526159071327740TCCATATTCCATATGTCCATAT0.9470.79TCCATATGG
GGCTGAGGCTGAGGAGGCTGAGCTGAGGAGG
GAGG/—GG = 0.999GAGG = 0.998
— = 0.001— = 0.002
1074730126208871328238G/CG = 0.995G = 0.9860.420.37G
C = 0.005C = 0.014
1205036326234571328495C/GC = 0.993C = 0.9750.2320.28C
G = 0.007G = 0.025
1205036826236871328518G/AG = 0.947G = 0.9450.9290.97G
A = 0.053A = 0.055
1243294926385871330008A/GA = 0.606A = 0.6010.8720.98A
G = 0.394G = 0.399
740137526399571330145T/AT = 1.000T = 0.9960.5860.02T
A = 0.000A = 0.004
801968226519571331345G/AG = 0.848G = 0.8120.2930.77G
A = 0.152A = 0.188
802124826562071331770T/CT = 0.597T = 0.6240.4261.12C
C = 0.403C = 0.376
1115898526583371331983T/AT = 0.242T = 0.240.9620.99T
A = 0.758A = 0.760
1048385026638771332537A/GA = 0.823A = 0.860.1421.32G
G = 0.177G = 0.140
801087526713071333280A/GA = 0.0630A = 0.110.01931.84G
G = 0.937G = 0.890
1162684426746871333618T/CT = 0.424T = 0.4160.8020.97T
C = 0.576C = 0.584
98297226760671333756A/GA = 0.56A = 0.5420.5750.93A
G = 0.440G = 0.458
716119826885871335008T/CT = 0.563T = 0.5730.751.05C
C = 0.437C = 0.427
716034726919371335343G/AG = 0.551G = 0.5530.9661.01A
A = 0.449A = 0.447
800713926999171336141A/GA = 0.735A = 0.7350.9921.00A
G = 0.265G = 0.265
801448327184071337990C/TC = 0.757C = 0.7620.8671.03T
T = 0.243T = 0.238
1243707227259271338742T/CT = 0.887T = 0.9050.4141.21C
C = 0.113C = 0.095
800476727339971339549C/GC = 0.865C = 0.8030.02030.64C
G = 0.135G = 0.197
1258883027350471339654A/GA = 0.304A = 0.3050.9861.00G
G = 0.696G = 0.695
715844927405071340200T/CT = 0.001T = 0.0010.9440.23T
C = 0.999C = 0.999
657410327418271340332C/TC = 0.033C = 0.0280.6820.83C
T = 0.967T = 0.972
802047827427571340425C/TC = 0.999C = 0.9980.910.59C
T = 0.001T = 0.002
490307727629371342443C/TC = 0.971C = 0.9730.8781.09T
T = 0.029T = 0.027
801235927664571342795G/AG = 0.292G = 0.2850.8030.96G
A = 0.708A = 0.715
489944927716671343316A/GA = 0.927A = 1.0002.12E−06113.75G
G = 0.073G = 0.000
1069028927829071344440AAG/—AAG = 0.977AAG = 0.9920.2392.65—
— = 0.023— = 0.008
657410427864671344796G/TG = 0.959G = 0.9750.3281.65T
T = 0.041T = 0.025
211055227902271345172A/GA = 0.747A = 0.7610.6381.08G
G = 0.253G = 0.239
800825627907371345223G/AG = 0.497G = 0.4740.480.91G
A = 0.503A = 0.526
75928328019871346348G/TG = 0.645G = 0.640.880.98G
T = 0.355T = 0.360
499917728110071347250A/GA = 0.001A = 0.0030.85337.48G
G = 0.999G = 0.997
233300628114571347295C/GC = 0.002C = 0.0070.7194.08G
G = 0.998G = 0.993
800617828265571348805A/CA = 0.802A = 0.7870.5830.91A
C = 0.198C = 0.213
1115898628283671348986A/CA = 0.0630A = 0.0540.6670.85A
C = 0.937C = 0.946
715062528353771349687C/TC = 0.999C = 0.9970.8490.55C
T = 0.001T = 0.003
800776828397671350126T/GT = 0.0660T = 0.0780.6591.21G
G = 0.934G = 0.922
800705828414971350299A/GA = 0.592A =
G = 0.408G =
DPF3-AA28474271350892C/AC = 0.86C = 0.880.3811.20A
A = 0.140A = 0.120
221590128484071350990C/TC = 0.966C = 0.9910.1633.66T
T = 0.034T = 0.009
381486628491271351062T/GT = 0.774T = 0.7790.8541.03G
G = 0.226G = 0.221
381486428509171351241T/CT = 0.464T = 0.440.4940.91T
C = 0.536C = 0.560
10605948250079-25008271316232CCCC/—CCCC = 0.649CCCC = 0.7370.004711.51—
— = 0.351— = 0.263
|
FIG. 1F shows proximal SNPs in and around the DPF3 region for females. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIG. 1F can be determined by consulting Table 44. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.
To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10−8 were truncated at that value.
Finally, the gene or genes present in the loci region of the proximal SNPs as annotated by Locus Link (http address: www.ncbi.nlm.nih.gov/LocusLink/) are provided on the graph. The exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.
Example 17
LOC145197 Proximal SNPs
It has been discovered that a polymorphic variation (rs1054745) in the LOC145197 gene is associated with the occurrence of breast cancer (see Examples 1 and 2). Subsequently, SNPs proximal to the incident SNP (rs1054745) were identified and allelotyped in breast cancer sample sets and control sample sets as described in Examples 1 and 2. Approximately 106 allelic variants located within the LOC14197 gene were identified and allelotyped. The polymorphic variants are set forth in Table 45. The chromosome position provided in column four of Table 45 is based on Genome “Build 34” of NCBI's GenBank.
TABLE 45
|
|
Position inChromosomeAlleleGenomeDeduced
dbSNP rs#SEQ ID NO: 7ChromosomePositionVariantsLetterIupac
|
|
28959072251499854375a/caM
24010195051499854655g/agR
240102051701499859320t/ccY
240102151831499859333t/ccY
199961168391499860989t/cgR
199961070161499861166c/taR
199960972371499861387c/tgR
227501681901499862340c/tgR
227501583571499862507c/taR
381877285771499862727c/gcS
10149458159991499870149c/tcY
7142383177221499871872c/tcY
11343023185431499872693t/—tN
11160641216391499875789c/acM
12586334247531499878903c/aaM
10142208262891499880439g/agR
7493230271201499881270c/aaM
5811036287371499882887a/—aN
10151926295621499883712t/aaW
12435354300781499884228t/ctY
7151007309741499885124c/tcY
11160642315451499885695t/ccY
11160643317791499885929t/atW
11626687340621499888212t/ccY
4906112348311499888981t/gtK
8016071349061499889056g/cgS
11623698349341499889084t/gtK
7401628349381499889088t/gtK
8015995351311499889281g/aaR
10873526355111499889661t/ctY
11160644357081499889858a/ggR
10134252360711499890221g/cgS
1959030368241499890974a/ttW
9707396369591499891109t/ggK
2401022373351499891485a/ttW
4622448373431499891493a/ggR
10141019385071499892657c/tcY
10141096385541499892704a/ccM
11621063386241499892774c/ttY
12434632386901499892840t/ccY
12100901387441499892894t/ccY
12434655387561499892906t/ccY
9944103395251499893675g/agR
7153189406821499894832g/aaR
7158860411811499895331a/ggR
12437080414141499895564g/cgS
11851768416571499895807g/aaR
12431943428211499896971g/aaR
4309341454751499899625g/agR
4329858456111499899761g/cgS
10690268457631499899913aaa/—aN
2401023460381499900188t/ccY
1054745463441499900494g/aaR
8019453466691499900819t/ccY
12431510469261499901076g/cgS
7141067470691499901219t/ccY
12431547472931499901443g/aaR
7142316476021499901752g/agR
1959029498211499903971q/acY
1959028498751499904025t/caR
11376292511781499905328—/agN
11376755511801499905330a/—aN
7145420517721499905922a/ggR
8013347519121499906062g/ttK
2144070522521499906402t/ctY
11850135522941499906444g/agR
11850138523171499906467a/ggR
1955617545481499908698g/agR
11621899548891499909039t/ccY
4900508553771499909527c/aaM
4906116554981499909648t/ccY
4906117556221499909772c/tcY
2235972557991499909949c/tcY
2235973559951499910145t/ccY
2235974560421499910192c/aaM
2235975563421499910492g/agR
7149416577811499911931t/ccY
11850809579831499912133a/ccM
10140476589061499913056t/ctY
12437309592571499913407c/tcY
6575852609261499915076t/gtK
4906118614621499915612a/gaR
11428825622411499916391—/ttN
11450744625411499916691—/taN
1999612636001499917750t/cgR
1889368639781499918128g/atY
1889367639831499918133g/ccS
1889366639991499918149g/atY
3077388640421499918192—/cttN
1889365642761499918426g/atY
1955615663081499920458a/gaR
1569807674001499921550t/ccY
2064491692551499923405c/tcY
2064492692631499923413t/ctY
761532709651499925115c/ttY
1955616715401499925690a/ggR
2144065746981499928848g/agR
2144066747461499928896c/tcY
2895908752211499929371a/gaR
2401043912891499945439t/aaW
1007904917961499945946a/ggR
3891113937621499947912c/ggS
3891114937801499947930g/cgS
730812942421499948392t/gtK
1884068948091499948959a/ggR
1884069948161499948966c/ttY
|
Assay for Verifying Allelotyping SNPs
The methods used to verify and allelotype the proximal SNPs of Table 45 are the same methods described in Examples 1 and 2 herein. The PCR primers and extend primers used in these assays are probided in Table 46 and Table 47, respectively.
TABLE 46
|
|
dbSNP rs#Forward PCR primerReverse PCR primer
|
|
2895907ACGTTGGATGAGCGAGAACTTATCTCTACCACGTTGGATGATCTTCTGACTAGCTGGGAC
|
2401019ACGTTGGATGGTGATGCCAGATACTTCCCGACGTTGGATGAGCACTGTGGGTCACTGTGG
|
2401020ACGTTGGATGCATTGTGCCTCAGTTTCCTCACGTTGGATGTTATGGAGCCCTTTCCACAG
|
2401021ACGTTGGATGAGCATTGTGCCTCAGTTTCCACGTTGGATGTTATGGAGCCCTTTCCACAG
|
1999611ACGTTGGATGTGAAAGCCCTTGGCAGGAGAACGTTGGATGAGACACTGGACCTAACTGAG
|
1999610ACGTTGGATGACCACCTCCCCACTATTCTGACGTTGGATGAACTCTGAGGTTCCAACCTG
|
1999609ACGTTGGATGACAAAAGGACTCGGATCTGGACGTTGGATGAGCTCTAGGGGAATCCTCTC
|
2275016ACGTTGGATGCTAGATCATTGGCCAGTGTGACGTTGGATGAAGAGGCATGCCGAAATGAG
|
2275015ACGTTGGATGTGACCTGCACAGCCCGGGAGAACGTTGGATGCCAATGAAAGAGGAGATGCG
|
3818772ACGTTGGATGGGTGGCTAGTAGGATGATTGACGTTGGATGGCATGGAACCCCACATGTAC
|
10149458ACGTTGGATGTGATCAAGGTTCCATCTTAGACGTTGGATGTATCCACCATCGTTCCAAAC
|
7142383ACGTTGGATGCCTGGCTCATTGAAGCATTCACGTTGGATGGAAGTTCACATTTCCAAGGG
|
11343023ACGTTGGATGTTTCATGCTTTTGGGACCAGACGTTGGATGGATTTCCCTATTTAACTGGC
|
11160641ACGTTGGATGACTTGAGCTCAGGAGTTTGAACGTTGGATGTACAGGTTTGTGCCACCATG
|
12586334ACGTTGGATGCTATCCTTCTACCAAAGGATACGTTGGATGTCAGAGTACTAGTCTTGAAC
|
10142208ACGTTGGATGAACAATTCTTCTGACGCTGCACGTTGGATGGGCATATACTGTATGGTTCC
|
7493230ACGTTGGATGATCCAGTCCTAGTTCCTTTCACGTTGGATGAGTCTCTTCTGGCTGTTTAC
|
5811036ACGTTGGATGGGAGAGATCGCTGGCTTGATACGTTGGATGTTGCAGTGAGCTGAGATTGC
|
10151926ACGTTGGATGCCTCTGTGTTAAGTCTATTCACGTTGGATGTAGCACATAGCTAGATACTG
|
12435354ACGTTGGATGACCTTCACTGAGAACACTGGACGTTGGATGACCTGGCCAATATGATGAGG
|
7151007ACGTTGGATGTGACACTGAGCATCTTTTCCACGTTGGATGGAATAGACACTTCACCAGAG
|
11160642ACGTTGGATGTAGTCCTAGCTACACGGGAGACGTTGGATGAGTGCAGTGGCACGATCTTG
|
11160643ACGTTGGATGAAATGCTGGGATTACAGGCGACGTTGGATGCTGGGTATAAACCCAAAGGG
|
11626687ACGTTGGATGGGGAATCACAGAAAGTGTCCACGTTGGATGCACACGTGGTCATAATGTGC
|
4906112ACGTTGGATGCCGGCCCTTTCTCATTTTTGACGTTGGATGATGAACCCAAAACCTGGTTC
|
8016071ACGTTGGATGCAGAGTGGCTGTCAATGAAAACGTTGGATGCCTGATCAATCTGTATAGAG
|
11623698ACGTTGGATGAAGAACCAGGTTTTGGGTTCACGTTGGATGAAAAAAGACCAGAGTGGCTG
|
7401628ACGTTGGATGAAGAACCAGGTTTTGGGTTCACGTTGGATGCAGAGTGGCTGTCAATGAAA
|
8015995ACGTTGGATGACCATTGGGATCGTGTTCAGACGTTGGATGCCGCTTAAGTGTTCCTCTAG
|
10873526ACGTTGGATGATCCATTCTCATCACATCCCACGTTGGATGACAAACACTACGTCCGTCTG
|
11160644ACGTTGGATGGGACTCCTCAAAACTGTCAGACGTTGGATGGTCTCTCTCAGCTTCTCTTG
|
10134252ACGTTGGATGTTTGAACCTGGGAGGTGGAGACGTTGGATGTGGAGTCTTGTTCTGTCACC
|
1959030ACGTTGGATGGAGGCACGCATCCAATTCAGACGTTGGATGGTGTCAGAGTGAGACTCTGT
|
9707396ACGTTGGATGGGGTTCAAGCAATTCTCCTGACGTTGGATGAAATTAGATGGGCGTGGTGG
|
2401022ACGTTGGATGACACAGGACTGTTGCAGTGGACGTTGGATGAAGACTACAGAGACTCCAGC
|
4622448ACGTTGGATGTACAGAGACTCCAGCATCTGACGTTGGATGTCAGATTTCCAGCCACACAG
|
10141019ACGTTGGATGGTCCATGAGAGACTTCCTTCACGTTGGATGGGGAATATTCGTGTCTGGAG
|
10141096ACGTTGGATGACACGGTGCAGAGGGTAAACACGTTGGATGCAAAACCCAGCTCTGACCTC
|
11621063ACGTTGGATGTTTACCCTCTGCACCGTGTGACGTTGGATGTGAGAAGCTAACAGCACAGG
|
12434632ACGTTGGATGCTCCTATGGTTAATGTTGGGACGTTGGATGGTGCTGTTAGCTTCTCATAC
|
12100901ACGTTGGATGAACTGGAAAATCCCTGCTGCACGTTGGATGTGTCAGCTACTCCACTCAAC
|
12434655ACGTTGGATGGGGTCATTATCAAAAAACTGGACGTTGGATGCCAACATTAACCATAGGAGAC
|
9944103ACGTTGGATGGCCCAAGGATTTGGGTAAACACGTTGGATGAATGCCGAATCCCTCAAAAG
|
7153189ACGTTGGATGCAAACTTCCAAGATAGACTGACGTTGGATGTGACTTGTATTCTCCAATTC
|
7158860ACGTTGGATGGTAAGTTTCATCCTGACCTCACGTTGGATGCTCCTTACTGACCTAAGGAG
|
12437080ACGTTGGATGTAAAGAGGGAGACTGGAGAGACGTTGGATGCCTTAGTTCAACCCTACCAC
|
11851768ACGTTGGATGACTTTCCTCAGGCCTCTTTGACGTTGGATGAAAGGACGTGTATGCTCACC
|
12431943ACGTTGGATGTTCGGGATCTCACAGTCTAGACGTTGGATGGGGCCGTACCTCCTTTTAAA
|
4309341ACGTTGGATGAAAGTACTGGGATTACAGGCACGTTTGATGAATCTCTTCCTGGGTCTTCG
|
4329858ACGTTGGATGATTCTCTTGCCTCAGTCTCCACGTTGGATGCCTGACCGACATGGAGAATC
|
10690268ACGTTGGATGCAAGAGCGAGACTCCGTTAAACGTTGGATGTTGATGATGCAGTCTTCGTG
|
2401023ACGTTGGATGGGGACCACTAGAGTCTAAACACGTTGGATGTGTCTGAAGCACCAGGAATG
|
1054745ACGTTGGATGGACTTTTAGGTCTGAGTTGGACGTGGATGCTTCCTCTAGCAGTGTATTTC
|
8019453ACGTTGGATGCCAGTCGTTTCAAAAGGAACACGTTGGATGGCTTCAATAGTCTGTAACCC
|
12431510ACGTTGGATGAAATTAGCTGGGCATGGTGGACGTTGGATGCCCAGGTTCAAGTGATTCTC
|
7141067ACGTTGGATGTTCTAGATGGAGGCGAAGAGACGTTGGATGCAAAGTGCTGGCATTACAGG
|
12431547ACGTTGGATGGCTAACTAACGGCTAATAGGACGTTGGATGAAGAAGCTCAATAGGCACTG
|
7142316ACGTTGGATGAGTATTCCAGAGGCTTGTGGACGTTGGATGTGACATCTGCCCAGCAGTAC
|
1959029ACGTTGGATGGCTAAGCTCTGCTTGAATTCACGTTGGATGCGAGTTGGATTATAGACTGC
|
1959028ACGTTGGATGAGTCTATAATCCAACTCGCCACGTTGGATGTGACAGAATGAGACTCTGTC
|
11376292ACGTTGGATGCTGTTTTTTCTGCTTTCTTCACGTTGGATGGGCTCCACAATTTTTAAGTG
|
11376755ACGTTGGATGGGCTCCACAATTTTTAAGTGACGTTGGATGCTGTTTTTTCTGCTTTCTTC
|
7145420ACGTTGGATGTGCCCTTGGTGAATTTCACGACGTTGGATGTACCTAGAAGTGGTAGGGAC
|
8013347ACGTTGGATGGCCGAAGATGTTTTCTACTGACGTTGGATGAGCAGCTATCCAGGTTATTC
|
2144070ACGTTGGATGGCCTGCTCTGTACCAGTAACACGTTGGATGTGTCTCACCCAATTTGGCTC
|
11850135ACGTTGGATGGTTTTAGCAGCTCAGAAGGGACGTTGGATGCCTCACACAGTTACTGGTAC
|
11850138ACGTTGGATGCCTCACACAGTTACTGGTACACGTTGGATGGTTTTAGCAGCTCAGAAGGG
|
1955617ACGTTGGATGGAAATAGAAGCACTTTGGGTACGTTGGATGCTTTTATAATAAAAATCTCTC
|
11621899ACGTTGGATGACTAGGTAAGGGAGTGAATGACGTTGGATGTTGGAAGATATTCCTGGCAG
|
4900508ACGTTGGATGCTAAGGTCTTCCTGTCACTCACGTTGGATGCCTTTCTTCCCAATTGCATG
|
4906116ACGTTGGATGAAAACCTGCGTGGTTGGATGACGTTGGATGCAGGCTGGAGAAGTCTAGAA
|
4906117ACGTTGGATGGCTACATTGAAGAAGGACGGACGTTGGATGTGCACGTCTTTAAACACAGC
|
2235972ACGTTGGATGTATCTTTTTTCCCCCATCAGACGTTGGATGGTAGGTTCAGGTGTCATTTG
|
2235973ACGTTGGATGCTTCTCGAGGTCAAGGTTTCACGTTGGATGGATGGTCAGGTCATCTCATG
|
2235974ACGTTGGATGCCTTGACCTCGAGAAGAAAGACGTTGGATGGTATGGCTGGGTAAAAATGC
|
2235975ACGTTGGATGGGTTTTACTGCAAATGTGCGACGTTGGATGTAAGTGGTAGGAAATGATAC
|
7149416ACGTTGGATGTTCTTCCCTGACTCCCTAACACGTTGGATGTGGAAGGCATTTCAAGCAGG
|
11850809ACGTTGGATGCAGGGATCTACTCCTTGGTCACGTTGGATGGAAGATGCAAGGTCAGCAGG
|
10140476ACGTTGGATGTTTCTAGAAATGCGAGCTGGACGTTGGATGGACCCATTTTCCAAATGTCAG
|
12437309ACGTTGGATGCTGTCGAAGTATTGAGCACCACGTTGGATGCTGAAGGACCGAACACAATC
|
6575852ACGTTGGATGACCTGGGTGCTGTGCTGCGGACGTTGGATGACGTGGGAACCGGGCTGTC
|
4906118ACGTTGGATGCCTCTGAGGTTGCAAATCTGACGTTGGATGTGGCGCCCATTTGGCTTTTT
|
11428825ACGTTGGATGAGAGCCCGTCTTTCTCCACAACGTTGGATGCCTTCAACCCATCTGGAAAG
|
11450744ACGTTGGATGAAACCCCAGATATTCCCTTGACGTTGGATGTGAGATAAAAGACACACAGG
|
1999612ACGTTGGATGACGTTGGAATGCCAGTTTGCACGTTGGATGTCCTGGGAATGGGCTTCTAC
|
1889368ACGTTGGATGACCTCTAGAATTTCCTGGCCACGTTGGATGCAAGGACAAGTGTCTTAGGG
|
1889367ACGTTGGATGACCTCTAGAATTTCCTGGCCACGTTGGATGTGTCGGCGACAAGGACAAGT
|
1889366ACGTTGGATGCCCTGATATCTCTTACTCCCACGTTGGATGAGTGTGTTCACGGGCAATGG
|
3077388ACGTTGGATGTGAACGCAGTGTGTTCACGGACGTTGGATGAAGACACTTGTCCTTGTCGC
|
1889365ACGTTGGATGCATGCTGCAGCCAAACATTGACGTTGGATGTAGGCAAGGCACCATCTCAT
|
1955615ACGTTGGATGCACTGCCCTGATGTCACACAACGTTGGATGTGCAGAGTGATAGGGTCAGG
|
1569807ACGTTGGATGCTGCAGAGTTCAAAGATGCGACGTTGGATGTCAGGTCCTGGAGTTAAAAG
|
2064491ACGTTGGATGAGTCACCAAAGCTAAGTGCCACGTTGGATGACACCGTCTCTGGGCTGAAG
|
2064492ACGTTGGATGACACCGTCTCTGGGCTGAAGACGTTGGATGAAGCTAAGTGCCAAGATGCG
|
761532ACGTTGGATGACCTTTAAGCCCAAGTTGAGACGTTGGATGACTGGCATGCAGTTGTTACC
|
1955616ACGTTGGATGACCAACTTCCACTCAGAAGCACGTTGGATGCAGCATGGCTTCATCTTAAC
|
2144065ACGTTGGATGAAATTAACCCTCGCAGAGGCACGTTGGATGGAGAAAGTTCCAGAAGAGGG
|
2144066ACGTTGGATGCCTCTGCGAGGGTTAATTTCACGTTGGATGCAGAAACACCCAGAGTGATG
|
2895908ACGTTGGATGAGAGATCAGAGAGAGAGAGCACGTTGGATGAAGGTGATTAGGTCAGGAGG
|
2401043ACGTTGGATGGTTACACACTTTCTAGGCTCACGTTGGATGTGGGCCCAAACTATCTCTAG
|
1007904ACGTTGGATGAGCGCAGTTGTTTGTCTCTCACGTTGGATGCCATGATGATGGAGCAACAG
|
3891113ACGTTGGATGGGGTTTGGAGAAGAAAGGAGACGTTGGATGGTGACTCACTGTCTAGTCTG
|
3891114ACGTTGGATGTCCTGTGACTCACTGTCTAGACGTTGGATGGAAAGGAGACTGGTTTGGG
|
730812ACGTTGGATGATTGGTGAGGTCTGGCTATGACGTTGGATGCCTGTAATCCCAGCACTTTG
|
1884068ACGTTGGATGCCACTGGGAAAAGGCACTTACGTTGGATGGTAGGGTTGTTGGGTCATTC
|
1884069ACGTTGGATGCTTTCAGAATAAGGGCCAACACGTTGGATGCTCTCAGACAGCGTTTTAAG
|
TABLE 47
|
|
|
dbSNP rs#
Extend Primer
Term Mix
|
|
|
2895907
ATCTCTACCAAACAATACAAAAAT
ACT
|
|
2401019
TGCGCAAAGTGCCAGAGCCC
ACG
|
|
2401020
TTCCGTGAATGGGAATG
ACT
|
|
2401021
CCTCAGTTTCCTCTTCC
ACT
|
|
1999611
AGGAGAGCAGCACTCAC
ACT
|
|
1999610
CCCCACTATTCTGATAACC
ACG
|
|
1999609
CAGAGTCCCCATGTGCACGC
ACG
|
|
2275016
GCCAGTGTGGTTGCAATT
ACG
|
|
2275015
AGCCGCTGCCCCAGGTG
ACG
|
|
3818772
TGCTTTGGTGCTCTCTT
ACT
|
|
10149458
CCAAATTTTGGTTGCTTCAAGG
ACG
|
|
7142383
TATAGACATTATCTGACAACACT
ACG
|
|
11343023
GGAGAATCTGCCCAGCTCAT
ACT
|
|
11160641
GCCTGGGTAACATGGTGAAA
CGT
|
|
12586334
AAAAACTTAAGATACATAGGGAC
CGT
|
|
10142208
CTTCTGACGCTGCTAACTAAC
ACG
|
|
7493230
AGTCCTAGTTCCTTTCTGTTTA
CGT
|
|
5811036
TTCCCAACTCTTTTTTTTTTTTTTT
ACT
|
|
10151926
TAGAGAGGATATAGAAAAGGAG
CGT
|
|
12435354
CTGAGAACACTGGTTGAGAGT
ACT
|
|
7151007
TTTTCCTGCCCTTATTTGTCAT
ACG
|
|
11160642
GAACCCAGGAGGCAGAGC
ACT
|
|
11160643
CCAGCCCACATGTGTCTTTAT
CGT
|
|
11626687
CACAGAAAGTGTCCTTTATAAAC
ACT
|
|
4906112
CCCTTTCTCATTTTTGATACTG
ACT
|
|
8016071
AGAGAAAACAAATGAACCCAAAA
ACT
|
|
11623698
GGGTTCATTTGTTTTCTCTATTG
ACT
|
|
7401628
TCATTTGTTTTCTCTATTGTCTG
ACT
|
|
8015995
CAGCTGAATGAAGACACTACA
ACG
|
|
10873526
CCATCAACATGGCTTATCACC
ACT
|
|
11160644
TCAGGGTCCTCAAAAATAAGG
ACT
|
|
10134252
GAGGTGGAGGTTGCAGTGA
ACT
|
|
1959030
ATTCAGCTGATGATCCC
CGT
|
|
9707396
TCTCCTGACTCAGTCTCCC
ACT
|
|
2401022
GGTCAGGCTCTTCAGCG
CGT
|
|
4622448
CCTGGTCTCTTCTCGCTGAA
ACT
|
|
10141019
CTGTCCTGCAAGCAGGGAA
ACG
|
|
10141096
GGTAAACCCAGGCTCACAG
ACT
|
|
11621063
GACAGGTGCTCCGCCAGA
ACG
|
|
12434632
TGTTGGGGTTGAGTGGAGTA
ACT
|
|
12100901
CCTGCTGCGGAGACTATTCA
ACT
|
|
12434655
AACTGGAAAATCCCTGCTGC
ACT
|
|
9944103
GGTAAACACACTCGCAACAG
ACG
|
|
7153189
TAGACTGCCTTTGTATATCTTTT
ACG
|
|
7158860
GCCAACAATGGCTACATCTTTT
ACT
|
|
12437080
GGAATTCTGTAATGTGGGCTG
ACT
|
|
11851768
GGTGCTACCTCTTTAGCCAC
ACG
|
|
12431943
TTTTTGCTTAGCATGGTGGAAA
ACG
|
|
4309341
CCGGGCCTTCCCTAGGTT
ACG
|
|
4329858
CCCGCCACCACGCCCGG
ACT
|
|
10690268
GACTCCGTTAAAAAAAAAAAAAAAA
ACT
|
|
2401023
TCTAAACTTGATAAGGCAAC
ACT
|
|
1054745
TTGGTCCATTAGGGAATTAGA
ACG
|
|
8019453
GGGAAATACTAGGAATGAATACT
ACT
|
|
12431510
GGCATGGTGGCGGGTGC
ACT
|
|
7141067
CATTGGCCGGGCATGGTG
ACT
|
|
12431547
TAGGGGAGAGCTAAAAACAAC
ACG
|
|
7142316
TGATGGCAGCATCTTATTACAT
ACG
|
|
1959029
CTTGAATTCTCATTGAGCATCT
ACG
|
|
1959028
TAATCCAACTCGCCTTCTCC
ACT
|
|
11376292
TAAAAAGTGGTAGACTTTTTTTTTT
ACG
|
|
11376755
AAGAATTTGCCCAGAAAAAAAAAA
ACT
|
|
7145420
ACCCGAAGCTAGGGTCGC
ACT
|
|
8013347
GAATATTCTATGATGTTAGGTGT
CGT
|
|
2144070
GAGGTGCTGGGGAGTGTGT
ACT
|
|
11850135
GCAAACATCCCCGGGAGC
ACG
|
|
11850138
CCCGGGGATGTTTGCTGAA
ACT
|
|
1955617
GATTTAAATGGGAGTATGATGTA
ACG
|
|
11621899
GGGGATGGTGAATGACCTCT
ACT
|
|
4900508
AGAGTGACCATTCCTATGTTC
CGT
|
|
4906116
TGCGTGGTTGGATGTTTTTCA
ACT
|
|
4906117
GAAGAAGGACGGTGACTCG
ACG
|
|
2235972
TCCCCCATCAGGACACC
ACG
|
|
2235973
GGTCAAGGTTTCAAAAATGG
ACT
|
|
2235974
GAGAAGAAAGAGAGAAAGCTTTTA
CGT
|
|
2235975
TGCGAACGATCCATCTA
ACG
|
|
7149416
TTTCCCCCACTGTCTCTGG
ACT
|
|
11850809
GGTCCCTGGTCTCTGGTTTT
ACT
|
|
10140476
ATGCGAGCTGGATTTTTAAACA
ACT
|
|
12437309
GAAGACTGTGGGAGTTTTGG
ACG
|
|
6575852
TGCGGCCAGGCAGAGCC
ACT
|
|
4906118
CAGTTAGGATGCGGGAGGC
ACT
|
|
11428825
CTTTCTCCACACCATTTTTTTTT
ACG
|
|
11450744
GATATTCCCTTGGTTAAAAAAAAAA
CGT
|
|
1999612
AGGTTTTGTGTCATCTAGC
ACT
|
|
1889368
CCTGCCACCCTGATATC
ACG
|
|
1889367
GCCACCCTGATATCTCTTA
ACT
|
|
1889366
CTTACTCCCTAAGACACTTG
ACG
|
|
3077388
CGGGCAATGGGCAGAGAG
CGT
|
|
1889365
AAACATTGACACCCCAAGTTC
ACG
|
|
1955615
CACTACCCTGATCTCACACA
ACT
|
|
1569807
AAGGCAGTTTGGAGAGC
ACT
|
|
2064491
AGCTAAGTGCCAAGATG
ACG
|
|
2064492
GGCACCAGGAGCAGGTCCTC
ACT
|
|
761532
TTCTGTCACTCACCCCC
ACG
|
|
1955616
GACAGGGTCTTTGCACAC
ACT
|
|
2144065
AGGCCGCCTCTTTATCA
ACG
|
|
2144066
AATTTCAGTGTCAACTTGG
ACG
|
|
2895908
TCTCTTCTTATAAGGGCACT
ACT
|
|
2401043
TAGCTTTATAGGACAGGTCTAG
CGT
|
|
1007904
CAGTTGTTTGTCTCTCTTGCCCA
ACT
|
|
3891113
AGAAAGGAGACTGGTTTGGG
ACT
|
|
3891114
CTGTCTAGTCTGTTCACTTTC
ACT
|
|
730812
AGCGATCCTCCCACCTC
ACT
|
|
1884068
CAGAATAAGGGCCAACT
ACT
|
|
1884069
ATAAGGGCCAACTGATGTAT
ACG
|
|
Genetic Analysis of Allelotyping Results
Allelotyping results are shown for cases and controls in Table 48. The allele frequency for the A2 allele is noted sixth columns for breast cancer pools and control pools, respectively, where “AF” is allele frequency. SNPs with blank allele frequencies were untyped.
TABLE 48
|
|
Breast
Position inCancer
SEQ IDChromosomeA1/A2Associated
dbSNP rs#NO: 7PositionAlleleCase AFControl AFp-ValueORAllele
|
|
289590722599854375A/CA = 0.342A = 0.3640.4641.10C
C = 0.658C = 0.636
240101950599854655G/AG = 0.282G = 0.3030.4771.10A
A = 0.718A = 0.697
2401020517099859320T/CT =T = 0.239
C =C = 0.761
2401021518399859333T/CT = 0.681T = 0.660.5030.91T
C = 0.319C = 0.340
1999611683999860989T/CT = 0.951T = 0.940.4890.80T
C = 0.049C = 0.060
1999610701699861166C/TC = 0.598C = 0.5920.8420.97C
T = 0.402T = 0.408
1999609723799861387C/TC = 0.434C =
T = 0.566T =
2275016819099862340C/TC = 0.609C = 0.6420.3161.15T
T = 0.391T = 0.358
2275015835799862507C/TC = 0.291C = 0.310.5241.09T
T = 0.709T = 0.690
3818772857799862727C/GC = 0.705C = 0.6650.1770.83C
G = 0.295G = 0.335
101494581599999870149C/TC = 1C = 10.9130.00C
T = 0T = 0.000
71423831772299871872C/TC = 0.991C = 0.9720.08790.31C
T = 0.009T = 0.028
113430231854399872693T/—T = 1T = 11
— = 0— = 0
111606412163999875789C/AC = 1C = 0.9990.9210.44C
A = 0.000A = 0.001
125863342475399878903C/AC = 0.435C = 0.3930.2590.84C
A = 0.565A = 0.607
101422082628999880439G/AG = 0.957G = 0.9720.5051.55A
A = 0.043A = 0.028
74932302712099881270C/AC = 0.001C = 0.0010.9395.70A
A = 0.999A = 0.999
58110362873799882887A/—A = 0.511A = 0.5360.4241.11—
— = 0.489— = 0.464
101519262956299883712T/AT = 0.001T = 0.0010.9880.32T
A = 0.999A = 0.999
124353543007899884228T/CT = 1T = 10.9981.10C
C = 0.000C = 0.000
71510073097499885124C/TC = 0.535C = 0.4960.2670.85C
T = 0.465T = 0.504
111606423154599885695T/CT = 1T = 0.9990.8960.46T
C = 0.000C = 0.001
111606433177999885929T/AT = 0.553T = 0.50.09660.81T
A = 0.447A = 0.500
116266873406299888212T/CT =T = 0.54
C =C = 0.460
49061123483199888981T/GT = 1T = 10.9910.76T
G = 0.000G = 0.000
80160713490699889056G/CG = 0.224G = 0.2730.151.31C
C = 0.776C = 0.727
116236983493499889084T/GT = 1T = 10.9680.68T
G = 0.000G = 0.000
74016283493899889088T/GT = 1T = 11
G = 0G = 0
80159953513199889281G/AG = 0.547G = 0.5620.6431.06A
A = 0.453A = 0.438
108735263551199889661T/CT = 0.579T = 0.5480.3340.88T
C = 0.421C = 0.452
111606443570899889858A/GA = 0.661A = 0.6730.7151.05G
G = 0.339G = 0.327
101342523607199890221G/CG = 0.003G = 0.0040.8291.84C
C = 0.997C = 0.996
19590303682499890974A/TA = 0.029A = 0.030.9081.06T
T = 0.971T = 0.970
97073963695999891109T/GT = 0T = 01
G = 1G = 1
24010223733599891485A/TA = 0.561A = 0.5630.9421.01T
T = 0.439T = 0.437
46224483734399891493A/GA = 0.001A = 0.0010.9931.32G
G = 0.999G = 0.999
101410193850799892657C/TC = 1C = 10.9740.71C
T = 0.000T = 0.000
101410963855499892704A/CA = 0.002A = 0.0030.9081.74C
C = 0.998C = 0.997
116210633862499892774C/TC = 0.5C = 0.4450.110.80C
T = 0.500T = 0.555
124346323869099892840T/CT = 0.371T = 0.3820.7261.05C
C = 0.629C = 0.618
121009013874499892894T/CT = 0.166T = 0.2110.1361.34C
C = 0.834C = 0.789
124346553875699892906T/CT = 0.408T = 0.4280.5321.09C
C = 0.592C = 0.572
99441033952599893675G/AG = 0.816G = 0.8190.9241.02A
A = 0.184A = 0.181
71531894068299894832G/AG = 0.001G = 0.0010.9861.43A
A = 0.999A = 0.999
71588604118199895331A/GA = 0.001A = 0.0010.9430.22A
G = 0.999G = 0.999
124370804141499895564G/CG = 0.883G = 0.8170.00810.59G
C = 0.117C = 0.183
118517684165799895807G/AG = 0.211G = 0.230.4711.12A
A = 0.789A = 0.770
124319434282199896971G/AG = 0.239G = 0.3140.02451.46A
A = 0.761A = 0.686
43093414547599899625G/AG = 0.999G = 0.9990.9240.59G
A = 0.001A = 0.001
43298584561199899761G/CG = 0.999G = 0.99911.00
C = 0.001C = 0.001
106902684576399899913AAA/—AAA = 0.454AAA =
— = 0.546— =
24010234603899900188T/CT = 0.731T = 0.7730.1781.25C
C = 0.269C = 0.227
10547454634499900494G/AG = 0.188G = 0.270.002281.60A
A = 0.812A = 0.730
80194534666999900819T/CT = 0.116T = 0.2490.0006072.52C
C = 0.884C = 0.751
124315104692699901076G/CG = 0.999G = 0.9990.981.17C
C = 0.001C = 0.001
71410674706999901219T/CT = 0.001T = 0.0020.971.45C
C = 0.999C = 0.998
124315474729399901443G/AG = 0.192G = 0.2940.0001961.76A
A = 0.808A = 0.706
71423164760299901752G/AG = 0.96G = 0.9930.05445.62A
A = 0.040A = 0.007
19590294982199903971G/AG = 0.898G = 0.8420.010.60G
A = 0.102A = 0.158
19590284987599904025T/CT = 0.941T = 0.8730.0004190.43T
C = 0.059C = 0.127
113762925117899905328—/A— = 0.322— = 0.310.680.94—
A = 0.678A = 0.690
113767555118099905330A/—A = 0.794A = 0.7850.7420.95A
— = 0.206— = 0.215
71454205177299905922A/GA = 0.301A = 0.2910.730.95A
G = 0.699G = 0.709
80133475191299906062G/TG = 0.16G = 0.2490.0006711.75T
T = 0.840T = 0.751
21440705225299906402T/CT = 0.774T = 0.7350.2240.81T
C = 0.226C = 0.265
118501355229499906444G/AG = 1G = 10.9651.64A
A = 0.000A = 0.000
118501385231799906467A/GA = 0.002A = 0.0020.9850.90A
G = 0.998G = 0.998
19556175454899908698G/AG = 0.534G = 0.5210.7360.95G
A = 0.466A = 0.479
116218995488999909039T/CT = 0.004T = 0.0090.7742.36C
C = 0.996C = 0.991
49005085537799909527C/AC = 0C = 01
A = 1A = 1
49061165549899909648T/CT = 0.038T = 0.0270.6190.70T
C = 0.962C = 0.973
49061175562299909772C/TC = 0.327C = 0.2760.09010.79C
T = 0.673T = 0.724
22359725579999909949C/TC = 0.726C = 0.6580.01930.73C
T = 0.274T = 0.342
22359735599599910145T/CT = 0.163T = 0.2350.02971.58C
C = 0.837C = 0.765
22359745604299910192C/AC = 0.163C = 0.2450.006331.66A
A = 0.837A = 0.755
22359755634299910492G/AG = 0.948G = 0.9670.1841.61A
A = 0.052A = 0.033
71494165778199911931T/CT = 0.662T = 0.7170.1781.29C
C = 0.338C = 0.283
118508095798399912133A/CA = 0.002A = 0.0020.9560.74A
C = 0.998C = 0.998
101404765890699913056T/CT = 0.93T = 0.9080.2980.75T
C = 0.070C = 0.092
124373095925799913407C/TC = 1C = 10.9543.60T
T = 0.000T = 0.000
65758526092699915076T/GT = 0.998T = 0.9990.8752.34G
G = 0.002G = 0.001
49061186146299915612A/GA = 0.892A =
G = 0.108G =
114288256224199916391—/T— = 0.6— = 0.570.3960.88—
T = 0.400T = 0.430
114507446254199916691—/T— = 0.574— = 0.5450.3870.89—
T = 0.426T = 0.455
19996126360099917750T/CT = 0.006T = 0.0050.9160.82T
C = 0.994C = 0.995
18893686397899918128G/AG = 0.429G = 0.4710.1861.18A
A = 0.571A = 0.529
18893676398399918133G/CG = 0.836G = 0.820.5620.90G
C = 0.164C = 0.180
18893666399999918149G/AG = 0.325G = 0.3310.8221.03A
A = 0.675A = 0.669
30773886404299918192—/CT— = 0.607— = 0.5630.1830.84—
CT = 0.393CT = 0.437
18893656427699918426G/AG = 0.721G = 0.7420.4611.12A
A = 0.279A = 0.258
19556156630899920458A/GA = 0.636A = 0.6150.50.91A
G = 0.364G = 0.385
15698076740099921550T/CT = 0.694T = 0.6870.8120.97T
C = 0.306C = 0.313
20644916925599923405C/TC = 0.406C = 0.3730.2980.87C
T = 0.594T = 0.627
20644926926399923413T/CT = 0.343T =
C = 0.657C =
7615327096599925115C/TC = 0.73C = 0.7920.06071.41T
T = 0.270T = 0.208
19556167154099925690A/GA = 0.546A = 0.6020.0971.26G
G = 0.454G = 0.398
21440657469899928848G/AG = 0.38G = 0.350.330.88G
A = 0.620A = 0.650
21440667474699928896C/TC = 0.567C = 0.5430.4580.91C
T = 0.433T = 0.457
28959087522199929371A/GA = 0.426A = 0.3580.03040.75A
G = 0.574G = 0.642
24010439128999945439T/AT = 0.001T = 00.9480.00T
A = 0.999A = 1
10079049179699945946A/GA = 0.514A = 0.5260.7321.05G
G = 0.486G = 0.474
38911139376299947912C/GC = 0C = 01
G = 1G = 1
38911149378099947930G/CG = 1G = 10.976C
C = 0.000C = 0
7308129424299948392T/GT = 0.903T = 0.8880.570.86T
G = 0.097G = 0.112
18840689480999948959A/GA = 0.558A = 0.5480.7480.96A
G = 0.442G = 0.452
18840699481699948966C/TC = 0.288C = 0.2560.2740.85C
T = 0.712T = 0.744
|
FIG. 1G shows proximal SNPs in and around the LOC145197 region for females. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIG. 1G can be determined by consulting Table 48. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.
To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10−8 were truncated at that value.
Finally, the gene or genes present in the loci region of the proximal SNPs as annotated by Locus Link (http address: www.ncbi.nlm.nih.gov/LocusLink/) are provided on the graph. The exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.
Provided hereafter are ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 genomic sequences (SEQ ID NO: 1, 2, 3, 4, 5, 6 and 7, respectively). Polymorphic variants are designated in IUPAC format. The following nucleotide representations are used throughout the specification and figures: “A” or “a” is adenosine, adenine, or adenylic acid; “C” or “c” is cytidine, cytosine, or cytidylic acid; “G” or “g” is guanosine, guanine, or guanylic acid; “T” or “t” is thymidine, thymine, or thymidylic acid; and “I” or “i” is inosine, hypoxanthine, or inosinic acid. SNPs are designated by the following convention: “R” represents A or G, “M” represents A or C; “W” represents A or T; “Y” represents C or T; “S” represents C or G; “K” represents G or T; “V” represents A, C or G; “H” represents A, C, or T; “D” represents A, G, or T; “B” represents C, G, or T; and “N” represents A, G, C, or T.
Following is an ICAM genomic nucleotide sequence that encodes ICAM1, ICAM4 and ICAM5 (SEQ ID NO: 1).
|
>19:10219601-10312200
1aggaggctga ggtgggagaa tggcgtgaac ctgggaggcg gagcttgcag tgagccaaga
|
61tcacgccact gcactccagc ctgggcgaca gagcgagact ccgtctcaaa aaaaaaaaaa
|
121aaaaaaaaaa agccaggcga ggtgactcac acccataatc gcagcacttt gggaggccaa
|
181ggcgggcaga tcgcttgagc ccagaagttt gagatctgcc tgggcaacaY ggcgagaccc
|
241tgtctctatg aaacaagaaa aaagaaagaa acgaaatact gttccatcat ttgccacata
|
301aaatctaaac tctctggtgc agaacagact tgcaaatctg cctgtaaaat catacaccgg
|
361attttggagt agacacacag gaggctgatt gtagtggtgg cttctgggag aagaactggg
|
421gggtaggggg cacagataag agtagacaga attttcactc tagtaatctt tgtaattttt
|
481gaaattctct ctaccaggtg tatgaatgac caatgaaaat atacaatagg ccaggcgcag
|
541tggctcacgc ctataatccc agcactttgg gaggctgagg cgggtggatc acatgaggtc
|
601aggagtccga ggccagcctg accaacatgg tgaaaccttg tctctacgaa aaatacaaac
|
661attagtcagg tagggagcat cacttgagaa caggagttca agaccagcct ggacaacaaa
|
721gcaagacctc tgcctctaca aaaaaaaaaa aaaaaaaaaa aaattgctgg gcatggtgga
|
781acatgcctgt ggcctcagct acttaggtgg ctgcagcaga ggatcatctg aggccaggaa
|
841ttcaagacta cagtgaacta taatcgttac actgcactac agactggtaa cagggtgaga
|
901tcctgtctca aaaacaacag caacaaaata aacgattaaa agacctttta aagttgcaaa
|
961atacatagag tcttaaacat gcatccacag ttatttattt atttatttag aaacggagtt
|
1021tcactcttgt tgcccaggct ggagtgcaat ggtgcggtat cagctcactg caacctccgc
|
1081ctcccaagtt aaaggaattc tgcctcagcc ttccaagtag ctggaattac aggcatgcgc
|
1141caccatgctc ggctaatttt gtatttttag taaagatggg gttttggcat attggccagg
|
1201atggtttcga acccctgacc tcaggtgatc cacccgcctc ggactcccaa agtgctagga
|
1261ttataggcat gagccaccac gcccggccgc attcagttat tcttgcaggg ataaaataca
|
1321caatgaaata cactatactt tttgttttct ttctttcttt tttttttttt tttttgagac
|
1381agagtctcac tcgtcgcatg ggctggagtg cggtgcggga tctcggctca ctgcaacctc
|
1441tgcctcctgg gttgaagcga ttctcctgcg tcagcctccc gagtagctgg gattacaggt
|
1501gcccgccact acgcccagct aatttttttg tatttttagt agagataagg tttcaccatg
|
1561ttggccaggc tggtctcgaa ctcctgactc gtgattcgcc caccttggcc tcccaaagtg
|
1621ctgggattac aggcgtgagc caccgcaccc ggccacattt tttttttttt ttttttgaga
|
1681caggatctta gtctgtcacc caggctggag tacagtggca tgaacatggc tcactgcagc
|
1741ctcaatctct tgggttcagg tgatccttct gccttagcct ccccattagc tgggaccaca
|
1801ggcatatacc atcacaccta gctaattttt aaatttttgg tagaggccag gcgcggtggc
|
1861tcacgcctgt aatcccagca ctttgggagg ccgagtcggg tggatcacct gaggtcggga
|
1921gttcgagacc agcctggcca aaatggtgaa accctgtctc tactaaaaat aaaaaataaa
|
1981aataaaaatt agctgggcgt agtggcgggc gcctgtaatc ccagctactc gggaggctga
|
2041ggcaggagaa tcgcttgaac ccaggaggca gaggttgcag tgagccaaga tcgcgctact
|
2101gcactccagc ctgggcaaca gagtgagatt ctgtctcaaa aaaaaaataa taataatgct
|
2161atttattgac tttacacctt gtaccaggca tgggaagctt tgcctccatt acgtcactga
|
2221atctcataac ctccttttcc agcagaggaa aatgaggttg gttcacagac cacgttgtca
|
2281gctgtgctct gtccagaacg cactggcctc caagtagaca gccctggact ggtagggaag
|
2341ccggctatga tccggtggcg ccccctggag gtctatcggg aacatggtaa agaacctaaa
|
2401aatgggtggg ccacagtagc tcatgcctgt aatcccagca ctttggggga ccaatgcggg
|
2461agaattgctt gagcccagga gttcaagacc agcctgggca acattgggag acccaccccc
|
2521cgccatctct acaaaaaaaa aattaggccg ggcgcggtgg ctcaggcctg taatcccagc
|
2581actttgggag gccgaggcgg gtggatcacc tgaggtcagg agttcaagac cagcctggcc
|
2641aacgtggtgc cacactgtct ctaataaaaa cacgaaaatt agggccgggc tcggtggctc
|
2701acgcctgtaa tcccagcact ttgggaagcc gaggcgggcg gatcacgagg tcaggagatt
|
2761gagaccatcc tggctaacac ggtgaaaccc cctctctact aaaaatacaa aaagttagcc
|
2821aggtgtggtg gcgggcgcct gtagtcccag ctactcggta agctgaggca gggaatcgct
|
2881tgaacccggg aggccgagat gtgcgatctc acaccactgc actccggcct gggcgacaga
|
2941gcgatactcc atctcaaaat acaaatacaa aataaaaaaa tacaatacaa aaatgagccg
|
3001ggcttgcgta cctgtagacc agctactcag gagacagagg caggagaatc ccttgagctc
|
3061tggaggtcga ggctgcagta agccatgatc ttgcccattg cactccagcc tgggcgacag
|
3121aggaagacct tgtctctaaa aaccaaaaca aagaaactaa aaataagcat tcggatttgt
|
3181tagggggcga caagggaggc actccaggat ctgtggactc cccactttgt tctgtccttg
|
3241gagagccctg gaaggtctga gaggggacgg gacctggttt aagggggtag gggagaggac
|
3301cctggtctag ggggtaaggg acacaaatac ctaatctgag gggtttcggg gggacatggc
|
3361cctgccctgg ggaatctaaa ctgggaggca tggtctggca ggcccaatcc tgaaggcttt
|
3421ctgagggcaa taaggccctg cctttaaaca aatgaaaaaa cgccaggcac ggtggctcac
|
3481gcctgtaatc ccagcacttt ggaaggctga ggcgggagga tcacgaggtc aggagatcga
|
3541gaccatcctg gctaacgcgg tgatacccgt ctctactaaa aatacaaaaa attagccagg
|
3601cgtggtggcg ggcgcctgca gtcccagcta ctcgggaggc tgaggcagga gaatggcgtg
|
3661aacccaggag gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggca
|
3721acagagcaag actccgtctc aaaaaaaaca aaaacaaaaa caaaaacaaa aacaaaaaaa
|
3781caaataaaaa aacaaaacca cataactgga taaagaaaaa accatctccg acagccttgg
|
3841aggcgggatg aaggcgtggc ccggtgggcg tgaccaacag caaaagttta agcgttattg
|
3901gctgtattcc ttagttgctc actccagaac tgcccactta tgggcggggg tcactccttc
|
3961aggcttaaca gtcattggct gaattgggcc agagaggtct cattggctga attcctgcac
|
4021cggctcgtcg gaggcgggac ccaaagtagg ctaggcctac ggaagctggg tcttcttgct
|
4081gtgaggtcgc gttccccagt gttacggagg gtccttgagg caggagtgaa aattgggtct
|
4141gggggttagt cctggggtgg aggtctgggc acgccgggtc ggaccccctc catcttcggt
|
4201tttgcacacc ccgctttcca gcgcggagtc gcggcgggta gggcggcgtc gcgtgcgtga
|
4261cgtcatccag cggcgcctcg cRaggctcca gtggccttga cctcccgcgg cgtgggaggc
|
4321tgcgcggcga tgctgcagtt cgtccgggcc ggggcgcggg cctggcttcg gcctaccggc
|
4381agccaggtga ggccaggggc tggaggcgtg gtcgaaggat gaaatttggg ggtgtccagg
|
4441ggtcgtctct cactttcgcc caacccttgc agggcctgag ttccctggcg gaagaggcag
|
4501cgcgtgcgac cgagaacccg gagcaggtgg cgagcgaggg taaggcaacc ggggtggctc
|
4561caggaggggc ggcgacagag aggtctgacc cttgacccta acctctgacc cccgcaatcg
|
4621ctccaggtct cccggagccc gtgctgcgca aagtcgagct cccggtaccc actcatcgac
|
4681gcccagtgca ggcctgggtc gagtccttgc ggggcttcga gcaggagcgc gtgggcctgg
|
4741ccgacctgca ccccgatgtt ttcgccaccg cgcccaggtg agcgagggct gtaatggtga
|
4801actgagtggc agagggatga agagcgggat ttcaggagtc acgatgactt tgggcttgta
|
4861cccttgggaa agtgctgtat ttctacagcc tccgtttctc cacctgtcaa aggggaatga
|
4921tgacagtttc ccctgctgta gcgctgtgtg agattgaagc ctgagaggtg acatcatcta
|
4981agggttaggg agacagaatt ctggagcccg actgattagg ttcaaatcct gccttcccct
|
5041cttgtccctc agtgtcccta ttttgtcagc ggtcgggagg ttgctgtgat gaataaatga
|
5101cttaattctg gcacataata agttctatag aaatgttgat aatctttgtt aactggtttt
|
5161tgcaaataag agcactaaaa agactaaacc attcctcggt gcctggaaga ggctgtttgc
|
5221attttagtta ccctgctgtt cataacatct ctaagaaaat gtaggggcca ccctgggcgc
|
5281agtggctcac gcctgtaatc ccagcacttt gggaggccaa ggcgggcgga tcacgaggtc
|
5341aggagatcga gaccatcctg gctaacatgg tgaaaccccg tctctactaa aaatacaaaa
|
5401aaaaattagc cgggcgtggt ggcgggcgtc tgtagtccca ggtactctgg aggctgaggc
|
5461aagagaatgg cgtgaacccg ggaggcggag cttgcagtga gccgagatcg cgccactgca
|
5521ctccatcctg ggcaacactc tgtctcaaaa aaaaaaaaaa aaaagaaaga aaagaaaatg
|
5581taggggccag ttactgtggc tcacatctgt aatcccagca cattgggagg ccgaggtggg
|
5641cggatcactt gaaaccagga gttgcagacc agcctggcca acatgatgaa accccgtctc
|
5701taccaaaaat acaaaaatta gccggacgtc ttagtgcaag cctgtagtcc cagctactca
|
5761ggaggctgag gcatgagaat cgcttgcacc tggggagatg gaggttgcag tgagccgtga
|
5821ttatactact gcactccagc ctgggcgaca gagacagact ccatctcaaa aaaaaaaaca
|
5881ggtgaaattg atttcaataa tgtatttaac ctgtatttaa aactatgtcg aaatcacatt
|
5941gtagcatggg gcactggcca tgtttcagat gttgagtatg tgactgtatg gaatggtata
|
6001gaactagaga ggaaaaccag tccctgaaga aggtggcaat aagtgaagtg taatagcagg
|
6061aaaaaagtaa tggtaggaaa aacaaggaag aaggggtggc tttttttttc tgagatgaag
|
6121tttcgctctt gtcgcccagg ctggagtgca atggcatgct ctcagctcac ttcaacctcc
|
6181gcctcctggg ttctactaat tctcatgcct cagcctcccg agtagccaga atgacagaca
|
6241tgtaccaccg tgcccagcta atctttgtat attttggaga gacatcactt tgccatgttg
|
6301cccaggctgg tcttactcct tgcctcaagt gatccacctg ccttggcctc ccaaagtgcc
|
6361aggattccag gcatgagcca ctgcacctgg tcagggtggc tctttcttta gaaggtacct
|
6421ttcagcagtt attggagctg ctacctgtag gctgagaaag aaccatccag gagaagagtg
|
6481tttcaggcag agggaacagc aagtgccaag gccctgaggc agaatttcaa gatggggtca
|
6541gtgaggggca gaggcaaatc gcccagggcc ctggaggcag aagggagaat cctgggtttt
|
6601cctatagtgg ggtgggagcg tttgaagcag agttgggctt ctcatgtgtc cttcctcccc
|
6661gcaggctgga catactgcac caggttgcta tgtggcagaa gaacttcaag agaattgtga
|
6721gtgcctaaat ggagcaaggt ggtgggaagg agcttcctgg ggaggttggg gataggaccc
|
6781agaggaagcc catcgctggg ttttctctgg actgctcggc tggggcctca tctgtctcct
|
6841gaactattca ccgatgggtc catttttggt tctctttttt ttgtttgttt ttgagatgga
|
6901gatggagtct cactctgtca cccaggctgg agtgcagtgg cgcaatcttg gttcactgca
|
6961acctccgctt cctgggttca agcgattctc ctgcctctgc ctcctgagta gctgggatta
|
7021caggtgtgca ccaccatgca ggctaatttt tgtattttta gtagagatgg agtttcacca
|
7081tgttggtcag gctggtctca aactcctgac ctcaaggaac ctacctgcct tggcctccca
|
7141aagtgctggg attacaggcg tgagccaccg tgcccagctc attttcagtt gttttctgat
|
7201cactcactga tgtgggcatt gtggtgggtg agaggatata gcagggacca cgaggacaaa
|
7261acaggcaagg tccggctgtg tgcaagtggc tcaggcctgt aatcccagca ctggaagctg
|
7321aggtgggtgg gttgcttggg gccaggaaag accagcctgg gaaacagcaa gacccagtct
|
7381ctaccccttc ccccacaacc ccaagaaaaa gatgggcaaa gtccctattc taatgaaggt
|
7441cacagtgtca tgggaggaga agtgaaggtg agtcagatgg tcatacgtaa tgtgtaatta
|
7501tgagcatgtc ccagagaatg ggacgttcaa ccttgggtct actgtagaag ctaaccagat
|
7561caaggaggca gtggggctag tgtggagata acaggaacag ggtgtgcaaa ggccctgtgg
|
7621cagggaccac aaggaagcca gtgttgccac agaggccagt gggagcagtg gggaggagtc
|
7681tgggttttgt gccaagaaca ttgaagaatc cattaccagt cagggtctta tccatccacc
|
7741ccagaggtct ggccagtcct ccccctgctc acaccttccc tggctcccca tcaccctagg
|
7801aataaagtca tcagtctgct attctgagtt cttcctgatt tccttgccct gctcctcttt
|
7861cctgattctc cctgtctgtg tcatttccca tggccctccc tccttgtggc tacaaccaca
|
7921ttaaaattgt tcaaaaaata ggccggcacg gtggctcaca cctgtaatct cagcactttg
|
7981ggaggccaag gcaggtggat cacttgaggc caggagttcc aaaccagcct agtcaacgtg
|
8041gcaaaacccc atctctactg aaaatacaaa aaattagctg gggccaggtg cggtggctca
|
8101cacctgtaat cccagtactt tgggaggccg aggcggatgg atcacgaggt cgggagatcg
|
8161agaccagcct gaccaatatg gtgaaacccc atctctacta aaaatacaaa tattagttgg
|
8221gtgtggcagc gggcgcctgt agtcccagct actctggagg ctgagacagg agaattgctt
|
8281gaacctggga ggcggaggtt gcagtgagcc gagatcgcgc cactgcactc cagcgtgggc
|
8341gacagagcga gactccatct caaaaaaaaa aattagccgg gcatggtgac aggcacccgt
|
8401aatctcagct actagggagg ctgaggcagg agaatcgctt gaatctagga atcagaggtt
|
8461gcagtgagcc aaggtcacac cacttgcact ccacagcctg ggtgacagag tgagactgcc
|
8521tcaaaaaaaa aaatcaatag ttcagaaaat accgagcacc ccctgcgtgc ccggtggcag
|
8581ggcccctgcc tttgtgaggc tggcatgggg caggagctgt gacttcttta ccctccccct
|
8641cgctccccaa gtactctgtg cttggccaga gagagcccgt catcatggtg cctcctgtct
|
8701gacttccccg tggcaggact gatctgcccg gctccctgac acctgcctcg tggacctgac
|
8761ccccctcctc tttgtgcctc cagagctatg ccaagaccaa gacgagagcc gaggtgcggg
|
8821gcggtggccg gaagccttgg ccgcagaaag gcactgggcg ggcccggcat ggcagcatcc
|
8881gctctccgct ctggcgagga ggtaacagga cagggtggag ggggcgggga ggggtggggg
|
8941ggccagggaa gggcctgggt gtttactcac acacagctgc gcacatctgg catggtatta
|
9001tgtcagccct gttccctcca cctcatggaa ccacctgggc tggtgacatc ggaactgagg
|
9061cccttggacc tcactaccca tataagggga cagagatctg ggagccatcc actcctccct
|
9121ctcgcatgcc ctgtctcttc agcctgtggc cacagcccct cttgacccca cctcctgtca
|
9181ccctctcctg acccacactt cccacagcac ccagagagct cttctaaatc gtggaacctg
|
9241aactccggac ctcggccttt gtgtggaacc tgaactcctg accttgtcat tgtgggccct
|
9301ggtggctgca cacctttccc cctcatcccc tcctttccct ctctgaccag gcagagatga
|
9361ctctctcttg ttttttcggt tgtgtttgtt tttaactttt tattttcttg aatgctaaca
|
9421agatgactca gggtggtgcc agccacccca tcacctgttt acctggccag ctctcctcac
|
9481ctttcagggt tctgggccac acctcctcca ggaagccccc cttgatctcc tttccttcca
|
9541catcccccgg agctaccctg atttcttcta cagctgagcc tcttttctgc cctgccggaa
|
9601tgtgaatggc atgagggcag ggaccatgtc tgttgtcttc tctgctgcat ttccaaggcc
|
9661caggcgaggg cagacaccaa cacatggtgc ttgcaggggt ctccctgact gttgttgctc
|
9721ccagatcata ctgcttgctc caccggagca tgtgcctgat gccttcctct cccgcttgac
|
9781ctgaaagttc gaacctcctg ataacttcag cattaacagc gtgcttgagt taagttcaca
|
9841ctctagccac tctatggaat ccacaccata actcatggtg tcctatgggg caggaactgt
|
9901ccgatctcaa ggtggtttgt tttttttatt gtttgctttt gagacaagat ctcgctctgt
|
9961tgcccaggct gtagtgcagt ggtgcaatca tagctcactg cagccttgag ctcctgggct
|
10021caagtgatcc tccatcctca gcctcccaaa atgctggtgt gagccacctt cgccagccct
|
10081gtctcagagt gtgacagctg ggaaaactga agcccagtga agcaaagtca ctggtcccat
|
10141gttgtccctg atccagcctc ccctgaggcc ccaccctctc tgccttgttc ctggcagcgc
|
10201cccctctctc gtcaccccat gccagccact gcagcagatt gctgacctcc aggctctgca
|
10261gtggccccta cctgctcaca tgcctctgtc cccgcaggag gtgttgccca tggcccccgg
|
10321ggccccacaa gttactacta catgctgccc atgaaggtgc gggcgctggg tctcaaagtg
|
10381gcactgaccg tcaagctggc ccaggtacag ccatgggggg gcccagacag ctgctagagg
|
10441tggggctgct ctggacccag ggttcaaacc atcctttcct tccaccagga cgacctgcac
|
10501atcatggact ccctagagct gcccaccgga gacccacagt acctgacaga gctggcgcac
|
10561taccgccgct ggggggactc cgtactcctc gtggacttgt gagggcacag ggcagagcag
|
10621gggcaggggg ccctgagctc cgtactctga gggttcaacc cccactccct ggcctctctt
|
10681acagaacaca cgaggagatg ccacagagca tcgtggaggc cacctctagg cttaagacct
|
10741tcaacttgat cccggctgtt ggtgagcaaa gagcccaggc ccctagagtg cgcatgtgca
|
10801ggctccgctg ttagaatcac agcggttcaa atccggcatc tggtcgctga gtggcctcag
|
10861gcagtgacca cgctcccgga cccaaccttc agcttgccca aagcaataat ctttcctaaa
|
10921gaagtgcttg gctggggatg gtggctcacg cttgtaatcc cagtactttg ggaggccaag
|
10981gcagtctggg caatatagtg aggctcccat ctgtactaaa aataaaaaag ttaggcgtgg
|
11041cgatgtgcac ctgtagtccc agctactcgg gggctgagcc aggcggatag cttgagctca
|
11101gggggccaag gctgcagtga gtcatgatcg caccactgca cccaaacctg gggagagagc
|
11161tagactcttg tctcaaaaaa aaaaaaaaaa aaaaaaaaaa agctccaaag tcacctctgt
|
11221caaagccaca gtctgttcct tccacagcca caagatggcg acatgagcct aagtcaagtc
|
11281ctgtccctca acccacgccc ctcgctggct tccccacctc tctcaggatg aaagcccaag
|
11341tcatcagggt ggcacgtcag gccctgcacg atgtgccccg tcacctccct gccctcccgt
|
11401catttgccct gggtctcccc caccagaatg ggagccagga gtcccagcca ggcacaggac
|
11461cgagcctggc tctcggtcag caggtgatga gctgggagca gctccttggc cagaggctta
|
11521caggcaacaa gcggccaggc agggtctggc cccgggctgc tgggctcaca aagtcacact
|
11581agaccacagt gacgatctct gtaagcacaa agggactccg atgtgggtgg ggtgaggaga
|
11641gaggcagccc cggcctgacc ggccccccgc cccgccccca ccccgccccc aggcctaaat
|
11701gtgcacagca tgctcaagca ccagacgctg gtcctgacgc tgcccaccgt cgccttcctg
|
11761gaggacaagc tgctctggca ggactcacgt tacagacccc tctacccctt cagcctgccc
|
11821tacagcgact tcccccgacc cctMccccac gctacccagg gcccagcggc caccccgtac
|
11881cactgttgaW gtgaagcacc tcttYtgagc caggccgagc ccctggccga cttgggagcc
|
11941tYaggcccac gcccaccctt cgaggaaggt gtcacctgga ccccttcatt ccacggagga
|
12001agctgaggcc acagggagcg gccatcgcca ttgggaaggg gcgactccac ggaRagccca
|
12061gacgggcttY tgcatccatt ccctcttttt gtttttaaaa taaattgtat ttttgaatca
|
12121aggaggataa agataacttc tcagtgtcat ttttgataat tgcattgaga acgatgagct
|
12181ccttcccagg ttctgggcac tgttggggat ccgccgtctc aagaggctca cggtctggtt
|
12241taggggaacc ccagggctgt ttgtggaaat tacaagaatt cacttacccg gtgagtcaga
|
12301ctccaggagc tcacaggtgc gtgggcgctg gcacttccta ggagctgact cctgccacat
|
12361ccctctcctg agcactgctg ccagccattc tcacccctga gagggtttgc agtcctgtct
|
12421gcgacagtac ttcatgcagc ctgagagtgt gtgcttgatt gtacaagtag atgttgtgta
|
12481aacctgagtt ttcagagtga cttcctgtaa gcacagtcag aaaagtaaat gtctctctgt
|
12541aagtgagcag ataagcacat gcttaaaaac accagctggg cgtggtgact cgcacctgta
|
12601accctagcac tttgggaggt caaggtggaa ggatcgtttg agctcagagc ttccagacca
|
12661gcctgggcaa catggtgaaa ccccatctct gcaaaaaata taaaaattaa gtgggcgtgt
|
12721tggcgtccac ctgtggtccc agctacttgg gaggctgagg tgggaggatc acctgagccc
|
12781aggaagcaga ggttgcagtg agctgagact gagccaccac acaccagcct gggtgacaga
|
12841gtgagacact gtcttaaaac cccaatatcc caatttttga gtttgctgag gttgccagcc
|
12901aagttaattt ttcttaacag ccataacaga ctataatata gacaatgtga tcgatttatt
|
12961taaagtcaac cagctgggcg cggtggctca cgcctataat cccagaattt taggaggctg
|
13021agccaggtgg atcaccggaa gtcaggagtt cgagaccagc ctggccaagc cgggagtggt
|
13081ggcgggcacc tgtaatccca gctacttagg aggctgaggt gggagaatcg cttgaaccca
|
13141ggaggcagag gttgcagtga gccaagatag cgccactgcg ctccagcctg ggtgacagag
|
13201caagattcca tctataaata aataaataaa taaagtcaat caggactgcc ttctgcctgt
|
13261gtgggcctgg ccaggctaag cagccacaca accctcccta cctgctgggc cacccctggc
|
13321tgaaaacctc tctggaatgc ctctcttggg attgccttca gagattgcaa cacattctcc
|
13381aaacaccctc agtggacata gactttgatc cttgaagcag cagatttgac taagtaaaaa
|
13441agaaaaagct attaaaacca gttggctggg cgcggtggct cacgcctgta atcccagcac
|
13501tttgggaggc cgaggcaggc ggatcacgag gtcaggagat cgagactatc ctggctaaca
|
13561cagtgaaacc ccatctctac caaaaataca aaaaattagc cgggcgtggt ggtgggcgcc
|
13621tgtagtccca gctactcagg agactgaggc aggagaatgg tgtgaacccg ggaggtggag
|
13681cttgcagtga gccgagatcg cgccactgca ctccactcca gcctggcgac agagctagac
|
13741tgtctcaaaa aaaaaaacag aggcgtgcca aagctcagca gaaaatgccg cctcatcact
|
13801cttcctcttg ccagtcttgt gggggcacca aggcctagag taacacccag ctgttggcct
|
13861gacagtgcct ggcccagcct ggagagttgc agccagaagt ataaatgtgg ttcagtctgc
|
13921gtcatacctg tcaggaaaca tggtgagacc aactgctgcc cagacggatt ttcaaaagaa
|
13981atgggtcaga acgtattccc ccacactgga atccctcagc cagattgagg ataaaaacag
|
14041gcatcagaaa aaaatgatac aggcaggcct ggtggctcat gcctgtaatc ccagcacttt
|
14101gggaggctga ggcgggagga tcgcctgagc acaggagttt gagaccagcc tgggcaacac
|
14161agtgagaacc tatctctact aaaaatagaa caattagcca ggcacggtgg tgtggctgtg
|
14221gtcccagcta ctctggaggc tgaggtggga ggatcacttg agccctaggg gtagaggctg
|
14281cagtgagcgg agatcacccc actgcaatcc agcctgggca acagatcaag accctgtctc
|
14341aaaaaaaaaa aaaagaaaag aaaacaaaag aaaaatatga tacactgact agaatgtgct
|
14401ttaaaataat tggcatagtt gggtatggtg gcatgcacct gcagtctcac ctacttggaa
|
14461agctgtggcc aggagtttga gaccagcctg ggcaacacag caagacctca tctctataaa
|
14521aaataggcgg ggagcagtgg ctcacgcctg taatcccagc actttgggag gccaaggcag
|
14581gcggatcact agaggacagg agttcaagac cagcctggcc aacatggtga aaccccatct
|
14641ctactaaaaa tacaaaaatt ggcaggatgt ggtggcgggt gcctataatc ccagctactt
|
14701gggaggctga ggcaggagaa tcgcttgaac ctgggaggca gaggttgcag tgagccgagg
|
14761tcatgacact gccctcaaac ctgggtgaca gagcaagact cggtctcgaa aaaaaaaata
|
14821atgaatgaat gaattaattc attaattaaa tagggggggt atatgagttt gttagggctg
|
14881ccgtaggagt gccacaaact gcaggggttg ggggggttag tcaacagaaa tttattctgt
|
14941cctgtttctg gaggctggaa gtccaaggtg aagaacaggg ttagctcctt ctaagggaaa
|
15001atctgttcca gatccctctc ctagcgtctg gtggtttgct ttgctgacta tctttgacat
|
15061tccttggctt gtagccacac tgcttcagtc tccaccttca tctttacatg atgttgtccc
|
15121tgtgggtatg tgtctgtttc tgtgtctaaa tttctccttt ttattttttt cttttttctc
|
15181tatctttttt tttagacgga gtcgcgctct gttgcccagg ctggagtgca gtggctcgat
|
15241ctcggctcac tgcaacttct gcctcctggg ttcaagcgat tctcctgcct cagcctccca
|
15301agtagctggg attacaggcg cccaccacca tgcctggcta atttttgtgt ttttagtaga
|
15361gaaggggttt cgccatattg gccaggctgg taacctcagg tgatccaccc gctttggcct
|
15421cccaaagtac tgggattaca agcgtgagcc accgaacctg gcctattttt tcatttattt
|
15481ttagacagag ttttgctctt cttgtccagg ctagagtaca atggcgcaat ctcggctaat
|
15541ctcaacctcc gcctcccggg ttcaggcgat tctcctgcct cagcctccca agtagctggg
|
15601attacaggca tacgccacaa tgcctggcta attctgtttt gttagcagag atggggtttc
|
15661accatgttgg tcaggctggt ctcgaactcc cgacctcagg tgatccaccc acctcagcct
|
15721cccaaagtgc tgagattaca gacacgagcc actgagcctg gccctctcct ttttattttt
|
15781aaaatatatt ttgtggacgg cagcagtggc tcacacctgt aatcccagca ctttgggagg
|
15841ccgaggcggg tggatcacaa ggtcaggaac tcgagaccag cctggccaat atggtgaagc
|
15901cccatctcta ctaaaaatat aaaaattagc caggcatggc cgggcgcggt ggctcacgcc
|
15961tgtaatccca gcactttggg aggccgaggc gggcggatca cgaggtcagg agatcgagac
|
16021catcctggtt aatacggtga aaccccgtct ctactaaaaa tacaaaaaaa aaattagctg
|
16081ggcgaggtgg caggtgcctg tagtcccagc tactcgggag gctgaggcat gagaatggcg
|
16141tgaacccggg aggcggagct tgcagtgagc tgagatcgcg ccactgcact ccagcctggg
|
16201tgacagagtg agactccatc tcaaaaaaaa aaaaaaaaaa tttagccagg cgtggtgtca
|
16261gaagcctgta gtcgcaacta cttgggaggc tgaggcagga gaatcacttg aacccaggag
|
16321gtggaggttg cagtgagccg agaccacatc acggcacatc taaaaaaaaa aaaagttttc
|
16381tgtttttgtt ttttgcaaaa ctactgaaat aaatacagtg agatatttat ttataaatga
|
16441gaacgaatta ataatgagcc gtaggctggg tgtggtggct catgcctata atcccagcat
|
16501tttggggggc caaggcaggt ggaacacttg aggtcaagag ttcgagacca ggctgaccaa
|
16561tatagtggaa ccccatctct actaaaaata caaaagaatt agccgggcat ggtgccgggc
|
16621gcctgtaatc tcagctatgg gaggctgagg taggagaatc gcttaaaccc tggaggcgga
|
16681ggttgcagtg aggcgatatc acgccactgc actccagcct gggggacaga gcgagactcc
|
16741atctctaaat aaataaataa ggagctgtat ttcaaaattt ggagaaggtg acactgagag
|
16801tactgaatac acagtttttt gtttttttgg ttttttttga gacagagtct cgctctgtca
|
16861cccaggctgg agtgcagtgg tgcaacctcg gctcactgca atctctgcct cccggttcaa
|
16921gcaaatctcc tgcctcagcc tcccgcgtag ctgggattac aggcacgcat ccccatgcct
|
16981ggctaatttt tgtattttta gtagagacgg gatttcacca tattggtcag gctgatctca
|
17041aactcctgac ctcgtgatct gcctgcctcg gcctcccaaa gtgctgggat tacaggcgtg
|
17101agccaccgag cctggcccca aaaaatattt atcaaaacta tgttaatgct ggccgggtgc
|
17161ggtggctcat gcctgtaatc ccagcacttt gggaggccga ggcaggtgga acacgaggtc
|
17221aggagattga gaccatcctg gctaacacgg tgaaaccccg tctctactaa aaaatacaaa
|
17281aaattagccg ggcgcggtgg tgggtgcctg tagtcccagc tactcaggag gctgaagcag
|
17341gagaatggca ggaaccgggg aggcagaggt tgtagtgagc tgagatcgcg ccattgcact
|
17401ccagcctggg cgacagagcg agaatccgtc tcgaaaaaaa aaaaaaaata cacacacaca
|
17461cacaaaaact gtgttaatgc ttaactacac aaaaatgata atcagataaa tatgcattta
|
17521tttagagaac tgcatgttgg tcagtccagt ccctgcagag ggaattccca gcatgacctc
|
17581attcacttgt gaagacagag caatccttgt gttttatttt tttaagatgg atctcactct
|
17641gttgcccaga ctggagtgca gtggcatgat ctcagccctc tgccacctcc accttccggg
|
17701ttcaagagat tctcatgcct cagcctcctg agtagctgag attacaggct tgtgcctcca
|
17761tgcccagcta atttttttat ttttactaga gatgaggttt caccagtttg ggcaggccgg
|
17821tctcaaactc ctgacctcaa gtgatccacc cacctcggcc tcccgaagtg ctgggatgac
|
17881aggtgcctgg tcagcaactg ttgtttagac atacacattt tatctgctcg tccagcatgg
|
17941tcagccctcc actttttaaa ttttatttta tttatttttt tgagacagag tctcactctg
|
18001ttgtccaggt tggagtccag tggcgtgatt tcggctcact gcaacctcta cttcccaggt
|
18061tcgagcaatt ctcctgcctc agcttcccga gtagctggga ttacaggccc gcgtccccac
|
18121acctagctaa tttttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt
|
18181ctcgaactcc tgacctcagg tgattctcct gccttggcct cccaaagtgc tgagattaca
|
18241ggtgtgagcc actgcacacg gccttaaatt ttatttatta tttatttatt tatttattta
|
18301gagacttagt ctcactctgt tgcccaggct ggagtgcagt ggcatggtct cggctcactg
|
18361cactccacct cctgggttca cgccattctc ctgcctcagc ctcccgagta gctgggacta
|
18421caggcgccca ccaccactcc cggctaattt ttgtattttt agtagagatg gggtttcact
|
18481gtgttagcca ggatagtctc gatctcctga cctcgtgatc cgcctgcctc ggcctcccaa
|
18541agtgctggga ttacttattt tgttttttgt agagacaggt tctcactgtg ttgcccaggc
|
18601tggtcttgaa ctcctgatct caagtgatct tcccacctca gtctctcaaa gggctgggat
|
18661tacaggggtg agccactgca ccccaccttc cctctacttt ttgacggttt ccttctgcta
|
18721tgaatgtgca tgtccagttg tctgcttctt agaactgata tttaccttcc tcatccatca
|
18781gccattggag gaggactggg accgctcaga ttattgatct gacccattct ttcggcaggg
|
18841tttcctggtg gctgtcttcc atcaccaaaa ctggaatcag aagagtttcc atagcccttt
|
18901ttttttcccc acatctttgc tgaagcagag ttttgaaaaa caaaaccaca aactaagcta
|
18961ttccccagaa gaaatctgta atcaaagata agctctgccg ggcacagtgg ctcacgcctt
|
19021ttggaggcca aggcgggcgg atcacctgag gtcaggagtt ctagacctgc caggccaaca
|
19081tggtaaaacc tcatctctac taaaaataca aaaattagct agatgtggtg gtgggtacct
|
19141gtagtctcag ctacctggga ggctgaggca agagaatcgc ttgaacctgg gaagtagagg
|
19201ttgcagtgag ccgagattgc accactgcac tccagcctgg gcgacggagt gagacgacct
|
19261cacaaaaatt tacataaata aaatgaaaag taaaataaaa atacaaaagt tggccgggtg
|
19321cgtttgctca cgcctgtaat cccagcactt tgggagggtg aggcaggcag ataatgaggt
|
19381aagaagatcg agaccatcct ggctaacacg gtgaaaccct gtctctacta aaaatacaaa
|
19441aaattagctg tgcgtggtga cacgcacctg tagtcccagc tatttgggag gctgaggcag
|
19501gagaatcact tgaacctggg aggtggaggt tgcagtgagc cgagatcgca ccactgcact
|
19561ccagcctggg ccacagagtg agactccatc ttgaaaaaaa aaaaaaatac aaaagttagc
|
19621caggggtgtt ggtgggtgcc tgtaatccca gctatttggg aggctaaggc agaagaattt
|
19681cttgaaccta ggaaacggag gttgcagtga gccgagatca cacctctgta ctccagcctg
|
19741gacaacagag cgagactttg tctcaaaaaa aaaaaaaaaa aaaaaactaa ataggccggg
|
19801agcagtggct catgcctata atcccagccc tttgggaggc caaggcaggt ggatcacttg
|
19861aggtcaggag tttgagacca ggctggccaa catggtgtaa ccccgtctct actaaaaaca
|
19921caaaaattag ccgggtctgg tggcgtatgt ctgtaatccc agctactcgg gaggctgagg
|
19981caggagaatc acttaaacct gggaggcagg ggttgcagtg agctgagatc gtgccactgc
|
20041actctagcca gggtgacaga gtgaaactct gtctcaaaaa attaaaaaag aaattcagca
|
20101agtaatgagt taaggaattc gaatattaag gcgagtgaca aggaacgccc aggatgtggc
|
20161ccaggatgga gtagggggga cactcattta ggagaaagct caggccacaa gacaggagga
|
20221gccagccttg ttggggttga agggaagagc attccaggct gagggaactg caaggcgttt
|
20281gcatgggaca ctatgggatg gcttctgccc ttggtgggca gcctctggtc tgaggccatt
|
20341ctttggcctg cctgactgtc tggcaaccgg gaggaagccc tgcccttcct ggagacagaa
|
20401acaaaggtct aggaaatatc tgcttccctt ttccttgaaa aacgcttaag ggaacggagg
|
20461actgggaggt gccgtctctc tctgccagcc tgccccctac catagccatc ccactcccat
|
20521ctcagaaagt gacccgccat cctccaaaag gctcggaccc tgatcaagga gtcatccccc
|
20581ttgtcccagc acctccagtt ggcccagcct ccaaaacgga tgtcaaattc agccctttct
|
20641ccaaggacac tgcccagtcc aggccccact atcattcatc tggactagaa cagtcacctc
|
20701ctctcccatc tcctggctgc agctcttgaa gcctcaactg ggcccctgtg aacacttgag
|
20761ttagggcaag gtccttcctc tgctcagaac cctctatacc tcccacctcg ctgggcataa
|
20821aagccaaagt cctggccagg cacggtggct cacatctgtt atcccagcac tttgggaggc
|
20881caaggggggc ggatcactag aggtcaggag ttagagacca acatggtgaa accccatctc
|
20941tactaaaaat acaaaaatta gctaggcgtg gtgacgcacc cctgtagtac cagctactcg
|
21001gtaggctgag gtgggagaat cgcttgaacc tgggaggcag agtttgcagt gagccgagat
|
21061cacaccactg tgctccagcc tgggtgacag aacgagactg gggttcagaa acaaacaaac
|
21121aaaacaacaa agtcctcctc aggtgacagg aacttgcacc tatctgccct gtcatctccc
|
21181tgcccgctcc tctcctcgaa tctctccttt gctaagcctg ctccagccac actgttctcc
|
21241tggctgttcc tttttttttt tttttttttt tttttttgag tctcactctc acccaggctg
|
21301gagtgcagtg cctctatctt ggctcactgc aacctccgcc tgccgggttc aagagattct
|
21361cctgcatcag cctcccaagt aggtggaatt acaggtgtgc accaccacac ccggctaatt
|
21421tttgtatttt gcatagagat gggggtctcc ctatgttgcc caggctggtc ttgaactcct
|
21481gggctcaagt gatcctScca tctcggcctc ccaaaatgct gggattacag gtgggaRccg
|
21541cgcccaggtg gatttttgtc tgactctgtt cattcctgtg tccccagtac ctggaaggac
|
21601gccaagcaca cagtaggcgc ttaaaaaaca ttgagccaca tgttgagaaa agaacggcac
|
21661cattgtggct gcaagtggga cKtgggccgc gcgggggagc tcgcgcacct cgggccgggg
|
21721caagagctca gtggaacccg cccgaggaag aacccgtggc gcaggatttt cccaggcctt
|
21781ctgaggacca ggggcgtccc ccgtcccacc ctgtgacttt gctcaggccg ttccggggcg
|
21841ggaattcaga actcctcagc cccccaagaa aaaaatatcc ccgtggaaat tccttgggaa
|
21901tgaccgaggc gggggaaata tgcgtctctg gatggccagt gactcgcagc ccccttcccc
|
21961gataggaagg gcctgcgcgt ccggggaccc ttcgcttccc cttctgctgc gcgacctccc
|
22021tggcccctcg gagatctcca tggcgacgcc gcgcgcgccc cacaacagga aaRccttagg
|
22081cggcgcggct tggtgctcgg agacttaaga gtacccagcc tcgacgtggt ggatgtcgag
|
22141tcttggggtc acacgcacag gcggtggcca agcaaacacc cgctcatatt tagtgcatga
|
22201gcctgggttc gagttgccgg agcctcgcgc gtagggcagg ggttcgagcg ccccttctcc
|
22261ctgcctcgcc tctgcgcctg ggggctgctg cctcagtttc ccagcgacag gcagggattt
|
22321cgagcgtccc cctcccctcc ctcgtcaaga tccaagctag ctgcctcagt ttccccgcgg
|
22381agcctgggac gcNNgcggag gggctcggcg cgtagggatc acgcagcttc cttccttttt
|
22441ctgggagctg taaagacgcc tccgcggcca aggccgaaag gggaagcgag gaggccgccg
|
22501gggtgagtgc cctcgggtgt agagagagga cgccgatttc cccggacgtg gtgagaccgc
|
22561gcttcgtcac tcccacggtt agcggtcgcc gggaggtgcc tggctctgct ctggccgctt
|
22621ctcgagaaat gcccgtgtca gctaggtgtg gacgtgacct agggggaggg gcatccctca
|
22681gtggagggag cccggggagg attcctgggc ccccacccag gcagggggct catccactcg
|
22741attaaagagg cctgcgtaag ctggagaggg aggacttgag ttcggacccc ctcgcagcct
|
22801ggagtctcag tttaccgctt tgtgaaatgg acacaataac agtctccact ctccggggaa
|
22861gttggcagta tttaaaagta cttaataaac cgcttagcgc ggtgtagacc gtgattcaag
|
22921cttagcctgg ccgggaaacg ggaggcgtgg aggccgggag cagcccccgg ggtcatcgcc
|
22981ctgccaccgc cgcccgattg ctttagcttg gaaattccgg agctgaagcg gccagcgagg
|
23041gaggatgacc ctctcggccc gggcaccctg tcagtccgga aataactgca gcatttgttc
|
23101cggaggggaa ggcgcgaggt ttccgggaaa gcagcaccgc cccttggccc ccaggtggct
|
23161agcgctataa aggatcacgc gccccagtcg acgctgagct cctctgctac tcagagttgc
|
23221aacctcMgcc tcgctatggc tcccagcagc ccccggcccg cgctgcccgc actcctggtc
|
23281ctgctcgggg ctctgttccc aggtgagtcg gggtggggat tgccgtcggg ccagttctcc
|
23341gaagccccgg gaggaccggc tcccgggtca ggtcatgcat gcttaggtag ctgtttatgg
|
23401gaaggagggg ctagagacag cgattgaaag gcaacagcca gtaggttcga atccagaccc
|
23461tgcatacctc cacgtgtggc cttgggctat agattgcagc tttaaaaaag ggtagggggt
|
23521tggagatgga ggggaggggc gggcctcgtt ttgttgccca ggccggtctt gaactccggg
|
23581ggtctagcct tacctcctgc ctcagcctcc cgaStagctg ggatgagagg tgtgaaccac
|
23641cgccttgctt ggctagattg cgtctcttac agtttctcag Ytgtaaaacg ggaaacgtta
|
23701tagcggccac ctggcagggt atcttggccc agcgcagcac ctggccccag gactcgatca
|
23761tgatggtttg ggaacttggc tctgtgccaa cccaacaagg cttaagggac ccccaccccc
|
23821ctcaagatgt atattctgtt cctcatcctc tctgcccctg gggaagtcca gggctgcttc
|
23881tacttggggg aattccagag ctgacttatc cgtggcccaa agctgagaag tgggacRccc
|
23941cagcacaccc tcccccagct ccagcccagc tagggaagag ggaaggggtc agagggtctt
|
24001tcatggtggt gtaagtttgg ggaaccagga gggtggRaga ttgacagctt ggttaacagc
|
24061tcaacaaagc ctgagatcca ggccagcacg gtagttcatg ccagtaatcc caacacttta
|
24121ggagccccag gcgggcgaat cacttaaggt caggagtttg agaccagcct ggccaacatg
|
24181gcaacatccc gtctctacta aaaatacaaa aattagctgg catggtggtg ggcgcctgtg
|
24241atcccagctg ctcgggaggc tgagggagga aaatccctta agcccacgag gctgaggttg
|
24301cagtgaacca agattgtgcc actgcactcc agcctgggag acatagcgag attctgtctc
|
24361aaaaaacaaa gcRttctgat ccggactcag acccagatcg cactgctttc tagctgagta
|
24421accatttctc tctatgaaat gggaatggtc ccagaatctc ccttggagaa tgtatggagc
|
24481cagtgtcctc acacccccat ccaagataga acaaatctga gacaggaatc tttgagtgag
|
24541gcagtgctgg gctcagacat tttttcccac cttcggaggc agcagaatYt gagggacctg
|
24601atccaaataa gccccttctt tctttctttt cttttctttt tttttttttt ttttttttga
|
24661gacggagtct cactNNgtcK cccaggctgg agtgcagtgg cgtgatctcg gctcactgca
|
24721acctctgcct cccaggttca aacgattctc ctgYctcagc ctccctgagt agctgggact
|
24781acaggcatgt gccatcacac ccggctaatc actgtgttag ccaggatggt ctcgatttcc
|
24841tgacctcatg atctgcccac cctgcctccc aaagtgctgg gattacatgc gtgagccaca
|
24901gtgcccaccc cgtaagcccc ttctttctta cctgcaaggt agccagttgc tacccatcct
|
24961gtgctgagtt acttgtatta gcaagggatg gggtggctat actcacccac cttacagatg
|
25021gggaaattga ggcccaaaga gggggaaact acRtgtctca gggagtgagg agccagtctg
|
25081attcctggag ggctgactgt ctccacctga cttcttagga gggaggaggg caccaacttc
|
25141acattaaaat ctggttggac acagtggctc acacctgtaa tcctggcatt ttgggaggct
|
25201taggcgggag gatcacttga ggccaggagt ttgagaccag ccttagcaac atagtgagac
|
25261cccatctcta caaaaatgtt tttcagggcc aggcgcggtg gctcacacct ataatcccag
|
25321cactttggga ggctgaggcg ggcggattac ctgaggtcag gagtttgaga ccagcctgac
|
25381caacatggag aaaccccgtc tctactaaaa gtacaaaatt acccgggcgt ggtggcgcat
|
25441gcctgtaatc ccagctactc gggaggctga ggcaggagaa tcgcttgaac ctgggaggcg
|
25501gaggttgcgg tgaactgaga tcgtgccatt gcactccagc ctgggcaaca agagctaaac
|
25561tccgtctcaa aaaaaaaaaa atgtttttca aatattagcc gggtatggtg gtgtcctgta
|
25621gtcccagcta cttgggaggc tgagatggga ggatcacttg agcccaggag ttcaaggtta
|
25681cagtgagcta tgattgtgcc actgtattcc agcctgggta acagagggag acccgtttaa
|
25741aaaaaaaaaa gtgatggcta aagtccttcc atggctccct attgccctca gtataaagaa
|
25801cacatgtggc tgggcgtggt ggttcacgcc tgtaatccca gcactttggg aggctgaggc
|
25861gggcggatca cttgaggcca ggagtttgag agcaggctgg ccgacgtggc gaaaccccgt
|
25921ctctattaaa aatacaaaaa ttagctgggc gtggtggtgc ttgcctgtaa tcccagatac
|
25981tctggaggct gaggcaggag aatMacttga acccgggagg caRaggttgc agtgagctga
|
26041gattgYgcca ctgcactcca gtctgagtga caaagcgaga ctccatctca aaaaaaaaaW
|
26101aaataaaaga acacatcttt agcatggcct tcagtgctca cgggatcttc ctgaattaat
|
26161ctccccctct tcatccttgc tcactcagct ccagccaccc tgccccggga catctgtact
|
26221tgcctggaac ttatttccct tttctccgga cagccagccc tttctcgtca tttagatctc
|
26281tgctgaaaca ttaccctgtc accaaagcac tgtctattct atcaccctgt tttgtttttg
|
26341tcaaagctca tattaacatc agttattaat tatcttgttt gctcataatt tttttttttt
|
26401tttttttgga gacagagtct cgttctgttg ctcaggctgg agtgcagtgg cacaatcttg
|
26461gctcactgta acctccacct cccaggttca agtgattctt gtgcctcagc ctcccaaata
|
26521gctaggacta caggcacgtc ccaccatgcc cagctaattt ttgtattttt agtggagacg
|
26581gggctttgtc atgttggcca ggctgatctc aaattcctga cctcaagtga tctgcccgcc
|
26641ttggcctccc aaagtgctgg gattacaggc gtgagccacc acacccggcc tgctcatgaa
|
26701ttttctcttt aacttccaca tcgaaggcaa agtattgtct tgttaaggct gtgcctccag
|
26761cacccagcac aggctgggcg cacattccct tgatgaacct gatttgtaat gcctgtYgcc
|
26821tcttccctcg tttcttctag gacctggcaa tgcccagaca tctgtgtccc cctcaaaagt
|
26881catcctgccc cggggaggct ccgtgctggt gacatgcagc acctcctgtg accagcccaW
|
26941gttgttgggc atagagaccc cgttgcctaa aaaggagttg ctcctgcctg ggaacaaccg
|
27001gaaggtgtat gaactgagca atgtgcaaga agatagccaa ccaatgtgct attcaaactg
|
27061ccctgatggg cagtcaacag ctaaaacctt cctcaccgtg tactgtgagt aactgagccc
|
27121ggagggctgg actaggcaga ccSggtggga gagacgtgca gRggcacctg cagaggcctg
|
27181ggggaatctt tgccacttgc tcgtagggtc aaggaggggc tccttgcagg gcaggtgggg
|
27241acatccttgg aaagtccctt tgtgaatttc tttgggtaca attaaagtat ttacaggctg
|
27301ggtgcggtgg ctcatgcctg taatcccagc actttgagag gctgaggctg gcggatcacc
|
27361tgagatcagg agtttaagtt tcgccaacat ggcgaaaccc tgtctctgct gaaaatacaa
|
27421aaatcagccg ggcatggtgt caagcgcctg taatcccagc tacttggaag gctgaggcag
|
27481gagaacgctt gaacctgaga ggcagagatt gcagtgagcc gcgatcgtgc cagtgcactc
|
27541cagtctggat aacagagcaa gattccatct caagaaaaaa aaaatgccat ctctctatgc
|
27601ctcactcttt gaacatatga cacggtcctg cttcagacac tttaataaaa gatgcaaatt
|
27661aagccaagtg tggtggcttg tacctataat cccaactact ccagaggctg aggcagaagg
|
27721atggtttgag cccaggagtt tgagaccagc ctgggcaaca gagtgagacc ctgtttcttt
|
27781cttttttttt tttttttttt tgagacggag tctcactctg tcgcccaggc tggagtgcag
|
27841tggtgtgatc tcggctcact gcaagctccg cctcccgggt tcacgccatt ctcctgcctc
|
27901agcctcccga gtagctggga ctacaggcgc ctgccaccat gcccggctca tttttttgta
|
27961tttttagtag agacggggtt tcactgtgtt agccaggatg gtctcaatct cctgacctag
|
28021tggtccgccc gcctcggcct cccaaagtgc tgggattaca ggtgtaagcc actgtgccca
|
28081tccaagaccc tgtttctacc ggaaaaaaaa agtaaataat ttagctgggc atcgtggtgt
|
28141gcacctgtaa tcccagctgc tcctgaggct gtgatgggag gattgcttta acccaggggt
|
28201tcgaatccta ggagttcgaa tccatcctag gcaacatagc aaaaccccat ttttatttaa
|
28261aaaaaaaaaa aaagatatga gttaaaacta gccctgggat ggcatttttc acatattggt
|
28321aacaaacRaa agaattgatg gccgggcgca gtggctcacg cctgtaatcc cagcactttg
|
28381ggaggccgag gcgggcggat cacaaggtca ggagatcgag accatcctgg ctaacatggt
|
28441gaaaccccgt ctctactaaa actacaaaaa attagccggg catggtggca ggcgcctgtg
|
28501gtcccagcta ctcaggaggc tgaggcagga gaatggcatg aacccgggag gcagagcttg
|
28561cagtgagcca agatcgtgcc actgcactcc agcctgggcg acagagcaag actccatctc
|
28621aaaaaaaaaa aaaaaaaaaa gaattgataa cagctgtgct gccaaggcta ttggaacgta
|
28681ggaggtccta ggacagtgct gttgggagca taaataagcc caaccctgtg gcgggaaatt
|
28741gggcatcagt tctcaaaatg tcatgggctg ggcacggtgg ctcacgcctg taatcccaSc
|
28801actttgggag gctgagggag gcggatcact tgaggtcagg agttcgagac cagcctgacc
|
28861accatggaga aaccccgtct ctattaaaaa tacaaaaaaa actagccagg catagtggca
|
28921catacctgta atcccagcta ctcgggaggc tgaggcagga gaatctcttg aaactgggag
|
28981gcagaggttg cggtgagctg agattgcgcc actgcactcc agcttgggca acaagagcaa
|
29041aactccatct caaaaaaaaa aaaaaaagaa ataaaagaag gtatgttgaa tatgagtggt
|
29101atgccaccct cacattaggg aagggcagtt tcggggaggc tgtatttatg tataaaatag
|
29161ccctaMaagg aagtgggaga aatgacaata ttagctggct atgagaagag aggctgggag
|
29221gctgtgggag agggcttggg tgtggagaat tctttttgtt ttttcctttt tttgagacag
|
29281agtttcactc ttgttgccca ggctggagtg caatggcacg atctcagctc Mccgcaacct
|
29341tcacctcctg agtttaagtg attctccggc ctcagcctcc cgactagctg ggattacagg
|
29401catgggccac tacgcctggc aaattttgta tttttagtag agacagggtt tctccatgtt
|
29461ggtcaggctg gtcttgaact ctgacctcag gtgatccgcc cgcctcggcc tcccaaagtg
|
29521ctgggattac aacgtgagcc actttgcctg gctgagaatt ctttttttgt tgttgtcttt
|
29581ttgagatgga gttttgctgt gtccccagcc tggagtgcaa tggtgtaatc tcagctcact
|
29641gcaacctctc cctcccgggt tcaagcaatt ctcctgcctc agcctcccaa gtagctggaa
|
29701ttacaggcgc ccagcaccac gccYggctaa tttttgtatt tttagtagag acgggatttc
|
29761atcatgttgg ccRggctggt cttgatctcc tgaccttgtg atctgcccgc ctcggcctcc
|
29821caaagtgctg ggattacagg cgtgagccac tgcccccagc cRagaatttc tctttgYgtc
|
29881cttcctactt tggggacttc gaatggtggg aaagagttat caaggccaaa ataaggaatt
|
29941caaatgaaaa caaaacaaaa tcaaagaaga aaaaacagaa gagcactggg caggctaggc
|
30001acgtggctca tgcctataat cccagtgatt tagaaggccg aagtagaagg atcgcttgga
|
30061ggccaggagt tggacaccag cctgggcaac atagcaagac cccatatcta caaaaaataa
|
30121aaaacctaac caagcgtgct ggcatactag tagtcccagc tactcaggag gctgaggtgg
|
30181gaggatcacc tgaKcctggg aggtccaggc tgtagtgagc cgtgatgaca ccactgcact
|
30241ccagcctggg tgacagaKaa agaccctgtc tctaaaaaat aaaaactggc caagtagctt
|
30301tgggattagc cttgggttcc agtcccagca aggcctttaa tagcttggga catgacttct
|
30361gcatttactt tgcaatcagg tgagacctcc tctgatgggg aaaatgacac ggtgagtgac
|
30421aaaggatgtt ctcctatcat tgtgtcaggg caaggaagcc tctgggtaaa tgatcaaatg
|
30481atcagctttg cttctgattt ggagggtggg tgagcagatg ctgaccttcc caggtgaggg
|
30541aagtccccRa acattcccag cagcttctgg aaaccccagg gaaacctctt tgaaggtctt
|
30601ttctgcatct ctgcctgata ggtctttttt tttttttttt tttttttYtt ttttttgaca
|
30661cacagtcttg ctctgtcgcc caggctggat cactgcaacc tccatctccc gggttcaagc
|
30721agttctcctg cctcatcctc tccagtagct gggattacag gcacctggca ccacgcctgg
|
30781ctaatttttg tatttttagt agagacaggg tttcgccaag ttggccaggc tggtctcgaa
|
30841ctctagacct ctggtgatcc acccgcctca gcctcccgaa gtgctgggat tacaggcttg
|
30901agccaccaYg cgcggctctg cctgatagct gagagcatag aactccaggt ttgagacctg
|
30961gMtctgccac atttctccct ctatgactgt gggtgcccca ctttgcctta gtttttacct
|
31021ctgtgaaatg gagcagatgg ctggcacagg tagcaaagga gtaaaagtta tgtgggaggg
|
31081tggtacctga gagagactct agcttggtct tgccccaccc ctggtgtaaa cataaagaag
|
31141cctccctgga tggctcaatc ttctccaaaa aggttagagg tgtaattcct agaggaggcg
|
31201accactagct gggctttgaa ggatgtgtag gagttcataa ggacaggcat tctgggcagg
|
31261aggaacagcc tgggcaaaag ttgggagcag ggagaaatct tgatggaggc aggaggagga
|
31321ggaggtaggt tggtgtRggc caggYgcagt ggctcacacc tgtaatccca gtgctttggg
|
31381aggccaaagc aagaggattg tttgagccca ggagttcgag accagcctgg gcaacatagc
|
31441gagaccctgt ctctaagaaa aaataaaaaa attagggtac agtggcatat gcttgtattc
|
31501tcaactactc tggaggctca agtgggagga tcaYttgaac ccaggaattt ttttgttttt
|
31561gtttttgttt ttttgagatg gagtctcact ctgtggccca ggctggagtg cagtggtgcc
|
31621atcttggctc actgcagcct cctccacctc ctgggttcaa ccgattctgc tgcctgagcc
|
31681tcccgagttg ctgggattaa ggtgcccacc atcatgccca gctaattttt ttgtattttt
|
31741agtagagata gggtttacca tgttagccag gctggtcttg aacgcctgac cgcaagagat
|
31801cctcctgcct cagtttccca aagtgctggg attataggtg tgagccactg agcctggtca
|
31861agcccaggaa tttgaggtta cagtcagcta tgattgcacc actgcattcc agcccaggtg
|
31921acagagagag acactgcccc tNaaaaaaaa aaaaaaattg attgatggga ggaagggtga
|
31981ggttggcaga gccttgaatg ccaggtggag gagctgggac tttccttctt ggggtgatag
|
32041ggagtcatgg agggtttStg agcaggccag ggattagata gctgaaggct ggatttactg
|
32101gaagccaaWg agcagttggc tatggtcctt gtccacgcgg cccatgttgt gggcagtgac
|
32161cgtattcaag aagggaagga cagacaagta tttgaatact tcagtgacca ggatttggta
|
32221aaggactgca ggtcagggtc aagaagaggt gagagcagga cagacttcct ccccgctgca
|
32281ccaggcagct gagctgggtt tcctctaggg gctgaggttt gagggtacct caagttctgc
|
32341aagagtctat aggaggtggt aagagagaag agctggaggt cagagttttc ttgactatat
|
32401Rtatatatat ttttttgttt ttgtttttaa cagcttaaca gctttctgtt ttatttttag
|
32461agacagggtc tcagggtctc actttgtcac ccaggctgga gtgcagtggt acaatcgtag
|
32521ctgactgcag cctcaaactc ccaggctcaa gaaatcctcc tcccaccctt agcctcctga
|
32581gtagcaggga ctacaggtgt gagccagcag gaagcccagc tggttttttt tttttctttg
|
32641gtgttttttg tttgtttgtt tgagaccgga gtttcgctct tattgcccag gctgaagtgc
|
32701aatggcagga tcttagctca ccacaacctc cgacccccag gatcaagcta ttctcttgcc
|
32761tcagccacct gagtagctgg gattacaggc atgcgacacc acacaaggct aattttgtat
|
32821ttttagtaaa gacagggttt ctccRtgttg gtcaggctgg tctYgaactc ccaacctcag
|
32881atgatccacc tgcctcggcc tcccaaagtg ctgagattac aggcatgagc caccgtgccc
|
32941ggcctttttt tttttttttt ttttNNtgag acagagtctc actctgtcgc ccaggcagga
|
33001gtgcagtggt Kcgatctggg ctcactgcaa gctccgcctc ccgggttcac tccatcctcc
|
33061tgccttagcc tcctgagtag ctgggactac aggcgcccac caccacgcct ggctaatttt
|
33121ttgtattttt agtagagacg gggtttcacc gtgttagcca ggatggtctY gatctcctga
|
33181cctcgtgatc cgcccgcctt ggcctcccaa agtgctggga ttacaggcgt gagccaccat
|
33241gtctggcctg gccaggctgg tcttgaactc ctgacttccg gtgatccatc tgttctggcc
|
33301tcccaaagtg ctgggattac aggcataagc caccacgcca tgccgaagcc cagcttgttt
|
33361ttaatttttt tttttttttt tggagaaatg aggtcttgca atgttgccca agctagcctt
|
33421gaactcctgg cctcaaatga ccccgccttg gcatcccaaa gtactgggat tacagatgtg
|
33481agccaccatg ccccagcctt gctttcttga gatacRattt agaataccat aagattcatc
|
33541ccttttaagc acataattca atgacttctg tacaaacaac catgactaca atctaatttt
|
33601aaaatatYtc aatcactcta aaMaagaaac ctcctgctta tgtacagcga ctctgtctac
|
33661ctcttaagtg aMttctccta cctttaatag ccctatttta cagttcagga aactgaggtt
|
33721cagNgagaca aagtcactta cccacagcaa agaagcaagg ctgggtatca aatgcaggac
|
33781ccccccKgtc ctgatgcttt tttttttttt ttttttttcc tctgagagag actctcactc
|
33841tgtcactcag tctagagtac agtggcgcga tctcagttca ctgcaatctc tgcctcctgg
|
33901gctgaagtaa tcctttcctc acaagtaaac ctcagcctct caagtagctg ggactacagg
|
33961cacacaacac cacgcctggc taatttttgt atttttaggt agagacgggg tttcactatR
|
34021ttggccaggc tggtcttSaa ctcctgacct caggtgatcc gcctgcctcg gccccccaaa
|
34081gtgttgggat tacaggcgtg agccaccaca cgcagccttt ttgttattag actctgtcat
|
34141tactgacttt tttttttttt taatagaaac agggtctttc tttcccaggS taaagtacag
|
34201tggcatgatc acagttcact atagccttaa actcctgggc tcaagtgatc ctcctgcctc
|
34261agcctcccaa gtagcaggga ctacaggtgt gcaccaccac acccagttaa ccattcattc
|
34321attcattcat tcatttattt tgagatggag tctcgctctg tcacctaggc tggagtgcag
|
34381tggcacgatc tcagctcact gcaacctcca cctcccaggt tcaagagatt ctcctgcctc
|
34441agcctcccga gtagctgaga ctacaggcgt gcaccaccat gccagactaa tttttgtatt
|
34501tttaatagag acggggtttc actctgttgg tcaggcttat ctcgaactcc tgacttcgtg
|
34561gatccaccct ccttggcctc ccaaagtgct gggattaaag gcgtgagcca ccgcgccctg
|
34621ccaacctttt tttaattttt cttagagatg ggggtctccc tatgttgccc aggcttgtct
|
34681tgaactcctg gcctcaagtg accctSttgc cttggcctca caaagtgcta ggattacagc
|
34741ctgagccatc acacctggcc aacaggtttt tttttttKtt ttgttttgtt ttttaaagaa
|
34801tgtctaggcc aggctcattt actttcacct gtaatcccag cactttggga ggccggggtg
|
34861ggcagatcac ttgaggtcag gaattcgaga ccagcctggg caacatgctg aaaccccgtt
|
34921tctactaaaa atacaaaaat tagctgggtg tggtgacacg tgcctgtaat cccagctact
|
34981caggaggttg aggcaggaga attgcttgaa cccaggaggc agaggttgca gtgagccaag
|
35041atcatgccat caccctccag cctgggcgac agaaggagac tcagtctaaa aacttaatta
|
35101attaattaat taaaaataaa aatacaaaaa ttaacctggt gtggtggtgt gtgcctgtaa
|
35161tctaagctac tcaggaggct gaggcaggag aatcccctga atcccagagg cagaggttgc
|
35221agtgagccaa gatcgagcca ctgtttgccc agtctagtgc actgggctgc tgaatttatt
|
35281tgaccagaca cctagcaata gactttgaag ttcttttcca cttttcactc taagatgctg
|
35341ctgtcatgaa taaggaatat tttgatcccc ttcacaaaca ctcggggccc tcttaccagt
|
35401tttcactgaa gatcttgaca ttcctatctg cttaggtgtc tgggcgtgtt tgggggagat
|
35461actgaagagg tagggctccc aggcaggtgc agttcgtctg ttaggcaggc agcaaggtcc
|
35521acttcaccag acacccccac ctctgttttc ctRcagggac tccagaacgg gtggaactgg
|
35581cacccctccc ctcttggcag ccagtgggca agaaccttac cctacgctgc caggtggagg
|
35641gtggggcacc ccgggccaac ctcaccgtgg tgctgctccg tggggagaaS gagctgaaac
|
35701gggagccagc tgtgggggag cccgctgagg tcacgaccac ggtgctggtg aggagagatc
|
35761accatggagc caatttctcg tgccgcactg aactggacct gcggccccaa gggctggagc
|
35821tgtttgagaa cacctcggcc ccctaccagc tccagacctt tggtgaggat tgaagaagcc
|
35881agcagggaga aggtgggggt ggggtatcct gcaatgcggt gcctgtggcc acaggatctt
|
35941ttgagatggg tgtggccccg gctaaggggt gcatgtgttc taggcgtatg tgacctaggc
|
36001tgctgagtgg ccctggaaga ggatctcgca ggagggggaa tgaaatgccc cagagaaggg
|
36061cttcgggacg tccatccctg tctgctcaca cctttcttct ctccctagtc ctgccagcga
|
36121ctcccccaca acttgtcagc ccccgggtcc tagaggtgga cacgcagggg acMgtggtct
|
36181gttccctgga cRgKctgttc ccagtctcgg aggcccaggt ccacctggca ctgggggacc
|
36241agaggttgaa ccccacagtc acctatggca acgactcctt ctcggccaag gcctcagtca
|
36301gtgtgacYgc agaggaYgag ggcacccagc ggctgacgtg tgcagtaata ctggggaacc
|
36361agagccagga gacactgcag acagtgacca tctacagtaa gaaggggcag gggcggagtg
|
36421gggcttcttg Rgggtgtgac ctgaacccgg ggcggggctc actgtgtgcc tattccaggc
|
36481tttccggcgc ccaacRtgat tctgacgaag ccagaggtct cagaagggac cgaggtgaca
|
36541gtgaagtgtg aggcccaccc tagagccaag gtgacgctga atggggttcc agcccagcca
|
36601ctgggccYga gggcccagct cctgctgaag gccaccccag aggacaacgg gcgcagcttc
|
36661tcctgctctg caaccctgga ggtggccggc cagcttatac acaagaaYca gacccgggag
|
36721cttcgtgtcc tgtgtgagtg gggctgctgg tcaatggccc ctatccccca aggcccaatc
|
36781tccctgaagg tcccataagg tcttgcctcc aagtcctgcc cccacccacc tccatgtcat
|
36841ctcatcRtgt ttttccagat ggcccccRac tggacgagag ggattgtccg ggaaactgga
|
36901cgtggccaga aaattcccag cagactccaa tgtgccaggc ttgggggaac ccattgcccg
|
36961agctcaagtg tctaaaggat ggcactttcc cactgcccat cggggaatca gtgactgtca
|
37021ctcgagatct tgagggcacc tacctctgtc gggccaggag cactcaaggg gaggtcaccc
|
37081gcRaggtgac cgtgaatgtg ctctgtgagt gagccggcgg gcagagctgg gtgggggcag
|
37141gggccatgga cctaatgcaa tcctcaccgc ctgttgtatc ctccccacag cccccYggta
|
37201tgagattgtc atcatcactg tggtagcagc cgcagtcata atgggcactg caggcctcag
|
37261cacgtacctc tataaccgcc agcggaagat caagaaatac agactacaac aggcccaaaa
|
37321agggaccccc atgaaaccga acacacaagc cacgcctccc tgaacctatc ccRggacagg
|
37381gcctcttcct cggccttccc atattggtgg cagtggtgcc acactgaaca gagtggaaga
|
37441catatgccat gcagctacac ctacYggccc tgggacgccg gaggacaggg cattgtcctc
|
37501agtcagatac aacagcattt ggggccatgg tacctgcaca cctaaaacac taggccacgc
|
37561atctgatctg tagtcacatg actaagccaa gaggaaggag caagactcaa gacatgattg
|
37621atggatgtta aagtctagcc tgatgagagg ggaagtggtg ggggagacat agccccacca
|
37681tgaggacata caactgggaa atactgaaac ttgctgccta ttgggtatgc tgaggYccca
|
37741cagacttaca gaagaagtgg ccctccatag acatgtgtag catcaaaaca caaaggccca
|
37801cacttcctga cggatgccag cttgggcact gctgtctact gaccccaacc cttgatgata
|
37861tgtatttatt catttgttat tttaccagct atttattgag tgtcttttat gtaggctaaa
|
37921tgaacatagg tctctggcct cacggagctc ccagtcctRa tcacattcaa ggtcaccagg
|
37981tacagttgta caggttgtac actgcaggag agtgcctggc aaaaagatca Ratggggctg
|
38041ggacttctca ttggccaacc tgcctttccc cagaaggagt gatttttcta Ycggcacaaa
|
38101agcactatat ggactggtaa tggttacagg ttcagagatt acccagtgag gccttattcc
|
38161tcccttcccc ccaaaactga cacctttgtt agccacctcc ccacccacat acatttctgc
|
38221cagtgttcac aatgacactc agYggtcatg tctggacatg agtgcccagg gaatatgccc
|
38281aagctatgcc ttgtcctctt gtcctgtttg catttcactg ggagcttgca ctatgcagct
|
38341ccagtttcct gcagtgatca gggtcctgca agcagtgggg aagggggcca aggtattgga
|
38401ggactccctc ccagctttgg aagcctcatc cgcgtgtgtg tgtgtgtgta tgtgtagaca
|
38461agctctcgct ctgtcaccca ggctggagtg cagtggtgca atcatggttc actgcagtct
|
38521tgaccttttg Rgctcaagtg atcctcccac ctcagcctcc tgagtagctg ggaccatagg
|
38581ctcacaacac cacacctggc aaatttgatt tttttttttt ttYcagagac ggggtctYgc
|
38641aacattgccc agacttcctt tgtgttagtt aataaagctt tctcaactgc ctcagccttg
|
38701tgtgagttga ggggaggtgt cacatccagc tggagtcctt tctaagcagc cacagcctga
|
38761tcctcccact tcctccccca agaaaacatt gtgggttgat ggYcataccc tgaggttctg
|
38821gtccaaatcg gactttctat gaccttctgg gtctctagtg aaaactaaag actcctctcc
|
38881agaaaaaaac atttggtttc taatgaggcc tggaatctta ttcttgacct ggggagcgga
|
38941atcccttttt gcagtactcc cgggccctct gttggggcct ccccttcctc tccagggtgg
|
39001agtcgaggag gcggggctgc gggcctcctt atctctagag ccggccctgg ctctctggcg
|
39061cggggcccct tagtccgggc tttttgccat ggggtctctg ttccctctgt cgctgctgtt
|
39121ttttttggcg gccgcctacc cgggagttgg gagcgcgctg ggacgccgga ctaagcgggc
|
39181gcaaagcccc aagggtagcc ctctcgcgcc ctccgggacc tcagtgccct tctgggtgcg
|
39241catgagcccg gagttcgtgg ctgtgcagcc ggggaagtca gtgcagctca attgcagcaa
|
39301cagctgtccc cagccgcaga attccagcct ccgcaccccg ctgcggcaag gcaagacgct
|
39361cagagggccg ggttgggtgt cttaccagct gctcgacgtg agggcctgga gctccctcgc
|
39421gcactgcctc gtgacctgcg caggaaaaac acgctgggcc acctccagga tcaccgccta
|
39481cagtgaggRa caggggctcg gtcccggctg gggtgagggg agggggctgg aagaggtggg
|
39541ggaagggtag ttgacagtcg ctctataggg agcgcccgcg gacctcactc agaggctccc
|
39601ccttgcctta gaaccgcccc acagcgtgat tttggagcct ccggtcttaa agggcaggaa
|
39661atacactttg cgctgccacg tgacgcaggt gttcccggtg ggctacttgg tggtgaccct
|
39721gaggcatgga agccgggtca tctattccga aagcctggag cgcttcaccg gcctggatct
|
39781ggccaacgtg accttgacct acgagtttgc tgctggaccc cgcgacttct ggcagcccgt
|
39841gatctgccac gcgcgcctca atctcgacgg cctggtggtc cgcaacagct cggcacccat
|
39901tacactgatg ctcggtgagg cacccctgta accctgggga ctaggaggaa gggggcagag
|
39961agagttatga ccccgagagg gcgcacagac caagcgtgag ctccacgSgg gtcgacagac
|
40021ctccctgtgt tccgttccta attctcgcct tctgctccca gcttggagcc ccgcgcccac
|
40081agctttggcc tccggttcca tcgctgccct tgtagggatc ctcctcactg tgggcgctgc
|
40141gtacctatgc aagtgcctag ctatgaagtc ccaggcgtaa agggggatgt tctatgccgg
|
40201ctgagcgaga aaaagaggaa tatgaaacaa tctggggaaa tggccataca tggtggctga
|
40261cgcctgtaat cccagcactt tgggaggccg aggcaggaga atcgcttgag cccaggagtt
|
40321cgagaccagc ctggacaaca tagtgagacc ccgtctatgc aaaaaataca caaattagcc
|
40381tggtgtggtg gcccgcacct gtggtcccag ctacccggga ggctgagttg ggaggatcct
|
40441ttgagccctg aaagtcgagg ttgcagtgag ccttgatcgt gccactgcac tccagcctgg
|
40501gggacagagc acgaccctgt ctccaaaaat aaaataaaaa taaaaataaa tattggcggg
|
40561ggaaccctct ggaatcaata aaggcttcct taaccagcct ctgtcctgtg acctaagggt
|
40621ccgcattact gcccttcttc ggaggaactg gtttgttttt gttgttgttg ttgtttttgc
|
40681gatcactttc tccaagttcc ttgtctccct Ragggcacct gaggtttcct cactcagggc
|
40741ccacctgggg tcccgaagcc ccagactctg tgtaKcccca gcgggtgtca cagaaacctc
|
40801tccttctgct ggccttatcg agtgggatca gcgcgggccg gggagagcca cgggcagggg
|
40861cggggtgggg ttcatggtat ggctttcctg attggcgccg ccgccaccac gcggcagctc
|
40921tgattggatg ttaagtttcc tatcccagcc Scaccttcag accctgtgct ttcctggagg
|
40981ccaaacaact gtggagcgag aactcatctc caaaataact taccacgctg gagtgagacc
|
41041acgaatggtg gggaggggag ggtcccacgg acatattgag ggacgtggat acgcagaaga
|
41101ggtatccatg tggtggcagc cgggaagggg tgatcagatg gtccacaggg aatatcacaa
|
41161actcgaattc tgacgatgtt ctggtagtca cccagccaga tgagcgcatg gagttggSgg
|
41221tggggggtgt caaagcttgg ggcccggaag cggagtcaaa agcatcaccc tcggtccctt
|
41281gttctcgcgt ggatgtcagg gccYccaccc accgagcaga aggcggactc aggggcgctc
|
41341cagggtggct cgagctcaca cacgctgagt agacacgtgc ccgctgcacc ctgggtaaat
|
41401acagacccgg agccgagcgg attctaattt agacgcccgc gaacgctgcg cgcacgcaca
|
41461cgtgtcctcg gctcgctggc actttcgtcc cgccccctcc gtcgcgtgcS ggagctgacc
|
41521cggaggggtg cttagaggta tggctccgcg gggtcaaaag gagaaggatc agtgagagag
|
41581gcatccccac accctcccct agaactgtcc tttccccatc cagtgcctcc caaatctctc
|
41641ttagtcccca aatgtatccc cgccctaagg ggcgctggtg ggaggagcta aatgtggggg
|
41701cggRgctcgg agtccagctt attatcatgg catctcagcc agggctgggg taggggtttg
|
41761ggaagggcaa cccagcatcc cccgatccca gagtcgcggc cggggatgac gcgagagagc
|
41821gtggtcgccc ccagaaggcc ctgggccatc atgccggcct ccacgtagac cccaggggtc
|
41881gctcactcct gccagctcgc cttcaccaag gccaggagct tagcgcacgc tcgcctcccg
|
41941cccccccgcc gcctctgccg ccgccccctc cttggaaacc aagttaccaa cgttaaacca
|
42001atccccaagc gcaactctgY ctcccccaca ccccacccgc cgcgccgcgc ggagccgtcc
|
42061tctagcccag ctcctcggct cgcgctctcc tcgcctcctg tgctttcccc gccgcggcga
|
42121tgccagggcc ttcgccaggg ctgcgccggg cgctactcgg cctctgggct gctctgggcc
|
42181tggggctctt cggcctctca ggtaagagcY ccgctctggt tcggggtgga cagggcgggg
|
42241gcggagtccc tggacctgag aaacggcctc ctgtccctcc cagctctgcc ctcgcctcgc
|
42301tSccacgcct ctgcccccac ctcgagcctg agtcttctcc ccttccccct cctccccaac
|
42361acacacccga gccccagctt cctgactcct cgatagcccc tacccgcttc gagatcctag
|
42421gtgttcttcc gcacccaacc cttcgccctg gagacccagt gtctctcctg tccgctcccc
|
42481gggtacctcc ttacgctStg ctgtgcacca tggtccacgR actggcatct tccccactcg
|
42541cggtccgcga agactccatc tctccaacta ccctgactca gaggcgctgt tcccgctcca
|
42601cccagaRccc tggcaaccgg gtccctcagc tgttcccgcg gttccttcca tgagcccagc
|
42661cttgcgtccc ggcKccgtgt tcttcaccgg gtgtagggtc cttcctgatc cttgacccag
|
42721cctcgtctct cctttgccct tgccgcaaac gcactctcct cgtatcccgg cattctgcca
|
42781ggaccctgag aactggttca tcccccatcc cccatcccgg gtccccttct ctcagccttg
|
42841ctgtgttcat ccaagaaccc acctttcctc tcctctacgc cctcccccca tgctttcccg
|
42901ccgctccatc ggcgctttgg agaccatgSc tctctgctac cacgtcccag agacaccctc
|
42961gaggtttaga ctctgggagt gcgcctttaa accggaggcc tgggcaSgac gcgggacgcc
|
43021tgggttcttt ccctggctgS agcctctcct cctcctcccc gccctctgag aacccttgac
|
43081tcgacatagg ggcgctaaga tgtcagggag ttggctcccc aggctcagcc cgcgtttccc
|
43141tgggcagcgg tctcgcagga gcccttctgg gcggacctgc agcctcgcgt ggcgttcgtg
|
43201gagcgcgggg gctcgctgtg gctgaattgc agcaccaact gccctYggcc ggagcgcggt
|
43261ggcctggaga cctcgctgcg ccgaaacggg acccagaggg gtttgcgttg gttggcgcgg
|
43321cagctggtgg acattcgcga gccggagact cagcccgtct gcttcttccg ctgcgcgcgg
|
43381cgcacactac aggcgcgtgg gctcattcgc actttccgtg agttctgggt ggccacgcgc
|
43441gtactccact actctccctc cctcccaggc cccgccccct gggtcccagg gtcctcccct
|
43501tcaggcccca ccttctgttc caagtcccgg Ygttcaaaga gctgcggact cttccccctt
|
43561gcagagcgac cagatcgcgt agagctgatg ccgctgcctc cctggcagcc ggtgggcgag
|
43621aacttcaccc tgagctgtag ggtccccggc gccgggcccc gtgcgagcct cacgctgacc
|
43681ctgctgcggg gcgcccagga gctgatccgc cgcagcttcg ccggtgaacc accccgagcg
|
43741cggggcgcgg tgctcacagc cacggtactg gctcggaggg aggaccatgg agccaatttc
|
43801tcgtgtcgcg ccgagctgga cctgcggccg cacggactgg gactgtttga aaacagctcg
|
43861gcccccagag agctccgaac cttctgtgag tgggtgtggg gaggagatgg ggacccagtg
|
43921gggtcggtcg gtgtttagga ggtttagagg tagatacatc tgaatgctga ccccgacttc
|
43981aaccctcgcc ggctgagctg tttccccctc cgtgccttga ggRKgataat acgataagat
|
44041agtgcatgtc aagtgcttag gacatattga gcgctcggag ttagttcaaa cttggttctt
|
44101cgacccctag ccctgtctcc ggatgccccg cgcctcgctg ctccccggct cttggaagtt
|
44161ggctcggaaa ggcccgtgag ctgcactctg gacggactgt ttccagcctc agaggccagg
|
44221gtctacctcg cactggggga ccagaatctg agtcctgatg tcaccctcga aggggacgca
|
44281ttcgtggcca ctgccacagc cacagctagc gcagagcagg agggtgccag gcagctgRtc
|
44341tgcaacgtca ccctgggggg cgaaaaccgg gagacccggg agaacgtgac catctacagt
|
44401aaggaaggag gcggggtctc cgcggctccg aggtgggacc agaggaatgc gaaggcgggg
|
44461cgaagagtgg gcgggacctc agtaccggaa caggcgtgKc ccgaggggcg gggcaggtgg
|
44521gggcggagac gtaatcgctg gggaggagga gcctgtacag cctgagaggc ggggcgccgt
|
44581accctagttc gttctcagca ccccgaggat tcgggcagat aaggggcggg ccttgaccgg
|
44641agggaggggt atggtcagta tactacgacc aaatgctccg cccccaggct tcccggcacc
|
44701actcctgacc ctgagcgaac ccagcgtctc cgaggggcag atggtgacag taacctgcgc
|
44761agctgggRcc caagctctgg tcacactgga gggagttcca gccgcggtcc cggggcagcc
|
44821cgcccagctt cagctaaatg ccaccgagaa cgacgacaga cgcagcttct tctgcgacgc
|
44881caccctcgat gtggacgggg agaccctgat caagaacagg agcgcagagc ttcgtgtcct
|
44941atgtgagttg gtgataaccc ctcgcccccc accttctggt gacttccaag gacccgcctg
|
45001ctYcctcacc gtgtcgtgga ggcggagcca tttcttacgt ctaagcctct gtaaccccac
|
45061gccctgcccg cagacgctcc ccggctagac gattcggact gccccaggag ttggacgtgg
|
45121cccgagggcc cagagcagac gctgcgctgc gaggcccgcg ggaacccaga accctcagtg
|
45181cactgtgcgc gctccgacgg cggggccgtg ctggctctgg gcctgctggg tccagtcact
|
45241cgggcgctct caggcactta ccgctgcaag gcggccaatg atcaaggcga ggcggtcaag
|
45301gacgtaacgc taacggtgga gtgtgagtgg gggtgcgcag RgtgcaYttc tatctggttc
|
45361aaggtctgga gggtggccag cctccaggga agagtaggag tagggtatga ggtgtccctt
|
45421tgggtgaggt tttgggaaag ggaagaggct ggttagtggg gttggagaaa gatcttggag
|
45481gatggaaggg accgggtggg cgtgccccta gcctagggcg tggtatttgg gcggagtcgt
|
45541ggaaaggcgg gcagtccaga gtgtttaagt ttttagRcga aaaaggcgcc actggtggct
|
45601caggaagctc ccagacagag tgcatgSctc gactagcgtg acacctcctt ggatcggcgt
|
45661ccaagggtta tgcagggaca acacttcgtg gaagccttgc cgcgccaagg agggtctagg
|
45721gacgtcagat ttgcccccaa accccaaagc caacaataca ctccctcctc cagacgcacc
|
45781agcgctggac agcRtgggct gcccagaacg cattacttgg ctggagggaa cagaagcctc
|
45841gctgagctgt gtggcgcacg gggtaccgcc gcctgatgtg atctgcgtgc gctctggaga
|
45901actcggggcc gtcatcgagg ggctgttgcg tgtggcccgg gagcatgcgg gcacttaccg
|
45961ctgcgaagcc accaaccctc ggggctctgc ggccaaaaat gtggccgtca cggtggaatg
|
46021tgagtagggg caccgcggag ttaggcagga tctgtgggac aaccccggct ggacttcctg
|
46081gcccccgtgt gagcccctgc aatcctgttt cccagatggc cccaggtttg aggagccgag
|
46141ctgccccagc aattggacat gggtggaagg atctgggcgc ctgttttcct gtgaggtcga
|
46201tgggaagcca cagccaagcg tgaagtgcgt gggctccggg ggcRccactg agggggtgct
|
46261gctgccgctg gcacccccag accctagtcc cagagctccc agaatcccta gagtcctggc
|
46321acccggtatc tacgtctgca acgccaccaa ccgccacggc tccgtggcca aaacagtcgt
|
46381cgtgagcgcg gagtgtgagc gaggcccagg cgggtaggga gcaggggtgc cccacggtcc
|
46441aggcactccc tgacatcccc catggctgYt ttgcagcgcc accggagatg gatgaatcta
|
46501cctgcccaag tcaccagacg tggctggaag gggctgaggc ttccgcgctg gcctgcgccg
|
46561cccggggtcg cccttcccca ggagtgcgct gctctcggga aggcatccca tggcctgagc
|
46621agcagcgcgt gtcccgagag gacgcgggca cttaccactg tgtggccacc aatgcgcatg
|
46681gcacggactc ccggaccgtc actgtgggcg tggaatgtga gtgggggcag caccggatgg
|
46741aggggacacg gtcctcggaa gaatgactcg cagcggtggg agcattcaag ggcacctctc
|
46801ccaatcccat tctcggggac agggaattcc agcctaaacc agggggtaat gaaaattcta
|
46861gccaggcgca gtggctcagg tctgtaatcc caacactttg gaaggttgag gcggatgaat
|
46921cacttgaggc caggagttcg agaccagccc ggccaacatg gcgaaaaccc gtctctacaa
|
46981aaattagccg gtcgtggtSg tgggcgcctg tggtcccagc tacttgggag gctgaggcag
|
47041gagaatcgct tgagcctggg aggcagaggt tgcagggagc cgagatcccg ccactgcact
|
47101ccagcctggg caacagagtg agactctttc ttagaaaaac agaaaaagaa aattataggg
|
47161aataggagca cggccctcct caaatcctgg attagaacac tgacctgggc ttcacctcct
|
47221tccattcggt gaagaagggc gaggaatttt agccgcaaca gcagYctgat tgtcggggaa
|
47281ggaggctctg ataggaggca ggatcctctt ctgcccatca gaggcgcggt ggtctcccat
|
47341cgatcgttgt gggccggagc agggcatttg atcagtggct gggccggcgc taagccccac
|
47401ttcaccttct gtgcccttca gaccggccag tggtggccga acttgctgcc tcgccccctg
|
47461gaggcgtgcg cccaggagga aacttcacgt tgacctgccg cgcRgaggcc tggcctccag
|
47521cccagatcag ctggcgcgcg cccccgRggg ccctcaacat cggcctgtcg agcaacaaca
|
47581gcacactgag cgtggcaggc gccatgggaa gccacggcgg cgagtacgag tgcgcaScca
|
47641ccaacgcgca cgggcgccac gcgcggcgca tcacggtgcg cgtggccggt MMgtggcagc
|
47701tggggagagg cggggcgagg tatctgagag ggggcgtgac ctgggtcttg gggcggccgg
|
47761ccccgcctgc ctccctctcg gtcccggKag actagRcggW agtgggacag aRtagaagtc
|
47821aaaggtgcct tagcgggtgg ggctgttgat cgcactttga ggggtgggag atggaggtgg
|
47881cagggggact gaattcaagg ggagggaccc tccggggctg tcactgctgc aggaaaggac
|
47941tttaaaactt gggctggatt ctgcgtggYg gaaacttgac ccaattcaca atccactgtg
|
48001gggaagattg gggagggacc aaagtcattg gatgWtggag ggagagaggg gtcaagatcg
|
48061ccttctctca cttcctgaag ctcctggggc tgggttctct ctggggtcgg gggaacctga
|
48121cctggtcctg ccggtcctca ttttttgggg gatggggaga gttgacttgt cgccaggggg
|
48181ctaagtgtgg tcacgggttt atatccccat gggctgaagt gcgatataaa tcgggactcg
|
48241ggtcgccctg gcactgggag tggccttatt gcatgggttg tctcccttct cccaaggcca
|
48301gacagtgagc tccccggggc atgaggactg acttcgtgcc tgtgggagtg cggggggcgg
|
48361tgggagaagc cccccggagc ttggccaccc tccgcgaggg tctccacccc gcaggtccgt
|
48421ggctatgggt cgccgtgggc ggcgcggcgg ggggcgcggc gctgctggcc gcgggggccg
|
48481gcctggcctt ctacgtgcag tccaccgcct gcaagaaggg cgagtacaac gtgcaggagg
|
48541ccgagagctc aggcgaggcc gtgtgtctSa acggagcggg cggcggcgct ggcggggcgg
|
48601caggcgcgga gggcggaccc gaggcggcgg ggggcgcggc cgagtcgccg gcggagggcg
|
48661aggtcttcgc catacagctg acatcggcgt gagcccgctc ccctctcccc gcgggccggg
|
48721ggacgccccc cagactcaca cgggggctta tttattgctt tatttattta cttattcatt
|
48781tatttatgta ttcaactcca agggcgtcac ccccattttc taSccatccc ctcaataRag
|
48841tttttataaa ggaactccct gtctccgctt ctgtttctgc aaggtggaac aagSccaggg
|
48901ttccagtcgt gacctcccga gttattcatt caaWaagcga tttttgagag ggcctggggt
|
48961ggtggcttag gcctgtaatc ccaggacttg tgggaggccc aggtgggagg atcccttgca
|
49021cccaagagtt tcagaccagc ctgggcaaca tagggagacc ctacaaaaaa tatttttcaa
|
49081aaattagcca aggccggtcg cggtggctca tgcgtgtaat cccaggactt tggaaggccg
|
49141aggcggccag atcacgaggt cgaggtcatg agatcgagac catcctggcc aatatggtga
|
49201aaccctgtct ctactaaaaa tacaaaaatt agctgggcat ggtggtgcRc gcctgtagtc
|
49261ccagctattc gggaggctga ggcaggagaa tcgctttaac cccggaggca gaggttgcag
|
49321tgagccgaga tcgtgccact gaactccagc ctggcgacag agcgagattc cgtcttaaaa
|
49381aaaaaaccag gcgtggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcggg
|
49441cggatcacga ggtcgggaga tcgagaccat cctcgctaac acggtgaaac cccgtctcta
|
49501ctaaaaatMc aaaaaaaaaa aaaaaaaaaa aattagccga gcgtggtggc gggcgcctgt
|
49561agtcccagct actcaggagg ctgaggcagg agaatggcat gaacccgggg agcagagctt
|
49621gcagtgagcc gagatcgcgc cactgcactc caccctggca gacagcaaga ctccgtctca
|
49681aaaaaaaaaa aaaaaattag ccagggccga gcacagtRct ctcgcttgaa tcccagaact
|
49741ttgggaaact aaggcggggg gggggggtca cttgaggtca ggagttcgag accaccctgg
|
49801ccaacgtggt gaaacacctt ctctaccaaa aatacaaaaa aattaaggcc gggtgaagtg
|
49861gctcacgtct gtaatcccag cactttgcga ggctgaggcg ggcggatcat ggggttagaa
|
49921gatcaagact gtcctggcta acatggtgaa accccgtcac taMtaaaaac acaaaaatta
|
49981gccgggcgtg gtggcacatg cctgtagtcc cagctactca agaggctgag gcaggagaat
|
50041cgctttaacc ccggaggcag aggttgcagt gagccaagat cgcaccactg cactccagcc
|
50101tgggcaatag agcgagactc tgtctcaaaa aaaaaccaaa aacaaaaaca aaaaaataca
|
50161aaaatttagc tgggctgtag tggcacacgc cctgtaatcc cagctactcg tgaggctgag
|
50221gcaggagaat tgctagaacc cgggaggtag agatcttgcc attgcactcc agcctgggca
|
50281acagaactag actttgtctc aaaaaaaaaa aaaaaaaaaa aaaagtgttt tttgaggggg
|
50341ctgggcatgg tggctcaagc ctgtaatccc aggacttttg ggaggcccag gtgggaggat
|
50401cccttgtgcc cacgagtttc agaccagcct gggcaacata gcgagaccct acaaaaaaac
|
50461atgtttcaaa aaaaaatttt tttttttgag atggagtctc gctctgtcgc ccaggctgga
|
50521cagcagtggc actatctctg ctcactgcaa gctccgtctc ccgggttcat gccattctcc
|
50581tgcctcagcc tcccaagtag ctgggattac aggcgcctgc caccacaccc agctaatttt
|
50641tttttgtatt tttagtagag atgggatttc accgtgttcg ccaggatggt ctctattcct
|
50701gacctcgaga tccacccgcc tcagcctccc aaagtgctgg gattacaggc gtgagccacc
|
50761gcgcccggcc tcaaaaaaaa aatttttttt ttgagatgga gtcttgctct gtcacccagg
|
50821ctggagtgct gtggtgtgat cttggctcac tgcaacctct gcctcctggg ttcaagcaat
|
50881tcccctgcct tggcttccca aatagctggg actataggca tgcaccacca cacccagcta
|
50941atttttgtat ttttagtaga gacagggttt caccatgttg gccaggctgg tctcgaactc
|
51001ctgacctaag gtgatccacc tgcctcggtc tcccaaagtg ctgggattac agctgtaagc
|
51061caccatgcct ggtgtatttt tcaaaaatta gccagacatg gtggtgcatg cctgtagtcc
|
51121cagctacttg ggaggctgag gcaggaggat cctttgagcc taggaggtca aagccacttc
|
51181cagctatgat atYgtcattg tgctccagcc caggtgacag aaccagaccc tgtctctaaa
|
51241aacaaacaac gaaaaaatcc aaaaactttt tttgaacacc tactatgcat caggcacaat
|
51301ctaagctgtc tttttctttt tctttttttt ttttttttga gacggagtct ctctgtcgcc
|
51361caggctggag tgcagtggtg taatctcagc tcactgcaag ctctgcctcc cacgttcaag
|
51421cgattttcct gcctcagcct cctgagtagc tgggattaca ggcgcgcgcc accactacgc
|
51481ccggctaatt tttgtatttt tagtagagac agggtttcac catgttggtc aggctagtct
|
51541ggaactactg acctcgtgat tcacctgcct cggtctccca acgtgctgga attacaagcc
|
51601tgagccactg tgcctggccc ggctggctgt cttttctcag tgtgacctag agctcgtcct
|
51661ctctcagtgc ctgttttctg ctctcttcac acccttgggc aggggtgggg gcctcactcc
|
51721ttcctcctac ttatctcttc cacccagcac tgccctctga tccgggtcac tcttggaggt
|
51781gggggctagg tgcttccccc aggcctggtt accggcagag ctgaggccgc cttgccaggg
|
51841tgggtggagg ccctctccgt tgtgcccctg ccctgagact tcggtgagac cttcctgggc
|
51901aggcactggc tgatgctatg ggtgtcagcc cttagcatgt cctccctgtt aaagggggca
|
51961cccctgcccc gccctcaatg cctcctttgt cctgtgtcca cccacagtgc ttcagtttac
|
52021ccccaccctg cctttccact cagcccatca tgattcagaa cagacacaca cagggtatcc
|
52081gctgcaaccc ccactacacg gcaccttccc ccctcatccc caacagcata aggcacagca
|
52141gctgggcctc ctccccacag cctcctcctc tgcccctcct ccctcaaaag caggaacacg
|
52201gagccctaga gaaggaagcc agtcccatgc aaacatgtaa tgagcaaaga tgagacgggg
|
52261aaatggcaca agagggcagg ccagtgctcg gtgctggagc caggggccag gtataacacc
|
52321caaaaaggca ccagccaggt gcagtccctg ccactaacag cacctcacct tttctgcctg
|
52381tgccctccct acttaatgat ctctctccgc tcctactgac ctcaaggtct ctttcagagc
|
52441cttcagatga gatatttatt ttagtaggtt ggtgcaaaag taattgctgt ttttgccatt
|
52501gaaagtaatg gcaggcaggg catggtggct cacgcctgta atcccagcac tttgggaggc
|
52561cgaggtgggc agatcacgag gtcaggagtt caagaccagc ctggctaaca tggtgaaacc
|
52621ctgtctctac taacaataca aaaaaaatta gccggacatg gtggcacacc cctgtagtct
|
52681cagctacttg ggaggctgag gcaggagaac tgcttgaacc ctgaagcgga ggctgcagtg
|
52741agctgaaatc acgccactgc actccagcct gggccacaga gtgagactgt ctcagaggaa
|
52801aaaaaaaaaa aaaaagtaat ggcaaaaact gcaattactt tttctttttc tttctgtttt
|
52861tttttttgtt tgtttgtttg tttgtttgtt tgtttgagac ggagtctcac tgtgtggccc
|
52921aggctggagt gcagtggcgc aatcttggct tactgcagcc tccgcctccc aggttcaagt
|
52981gattctctcc tgcctcagcc tcccaatagg attacaggca cccaccacta tgcctggcta
|
53041atttttgtat ctttagcaga gatggggttt caccatgttt gccaggctgg tctcgaactc
|
53101ctgatccacc cacctcagct tcccaaagtg ctgggattac aggcaggcat gagccatggt
|
53161gcccgacatt tttttttttt tttctttttt tttttgagac agagtctcac tttgtcaccc
|
53221aggctggagt gcaaaggcaa gatctcactg cagcctctgc ctcctgggtt aaagcgattc
|
53281tcccacctta gccccctgag taggtgagat tacaggcaca tgccaccaca cctgcctaat
|
53341ttttgtattt ttaatagaga gggggtttca ccattttgtc cacgctggtc tcgaactcct
|
53401gacctcaagg gattcgccca cctcagcctc ccaaagtgct gggattacag gcatgagcca
|
53461ccacgcccga cctccttaac tcttttattt ccttgcacac tttttctctg tagcccagct
|
53521cacaacttaa catcctctta gacatacacc tgaggttttt tttttttttt tttttgagag
|
53581ggagtctctc tctgtcaccc aggatggaat gcagtggtgt gctctcagct cactgcaacc
|
53641ttgcaaccac tgcctcccag gttcaagcaa ttctcctgcc tcagcctccc gagtagctgg
|
53701gactacagac acatgccgcc acacctggct gattttttgt tttttagtag agacagggtt
|
53761tcaccgtgtt gcccaggctg gtctcaaact cctgagttca ggcagtccgc ctgccttagc
|
53821cttccaaaat gctgggatta caggcatgag gcaccgcgtc ctgcctctga gttttttttt
|
53881tttttttttt tttactgtct cctagaacat cagccccagt agagcaggga tctttgttct
|
53941gttcaccact gagggtcctc attgggtcct agcacacaca gttgctcaat aaatgttgaa
|
54001taagtgggta aagacagcca cgagcttgca gatatgtgtt caaggtgtgt ccttgcagag
|
54061agcttctcta tacttggcac tggagaggcc tgtcgtgggc aaggacatag atgtggcgac
|
54121ctcagacttg agaactcctg gggcagtagg ggagatggat gtggataatg taaccataag
|
54181ccttcctttc tattttagac tgagtggtca aggaaggctt ccagacaatg gaaattctga
|
54241taggttctaa gagggagacc agcaaggagc tgaaccggag gctgacacag ggtgagagtg
|
54301ggaatgtcta ttttattttt tttttggaga cagggtctca ctctgttgct caggcagcag
|
54361tgcagtggca cgatcgtggc tcactgcagc ttcaacttcc cagactcaag tgatcctccc
|
54421acctcagcct cccaagcagc tgggaatata ggtgcatgcc accacatccg gctaattttt
|
54481gtatttttgg tagaaacggg gtttcaccat gttgcccagg ctggtcttga actcctgggt
|
54541tcaagtgatc ttgctgcctt gggctcccaa agtgcttgga ttacaggtgt gagcctgtga
|
54601gccacatctg gcctatttta ttttttaatt agttttttgt ttttgttttt gttttgagat
|
54661ggagtctctg tctccaaggc tggagtgcag tggcacgatc tcggctcact gtaacctcca
|
54721cctcccaagt agctgggatt acaggcacat gccaccacgc ctggctaatt tttgtatctt
|
54781tagtagagac agggtttccc catgttggcc aggctggtct cgaactcctg acctccggtg
|
54841atccacctgc ctcagtttcc caaagtgctg ggattatagg aatgagccac tctgcctggc
|
54901tgggcatgtg tcttgttttt ttcattctgt agataacaag caattgtcct ccctcagcct
|
54961cccaagtagc tggtactaca ggcgcctgcc actacgcccg gctatttttt gtagttttag
|
55021cagaggtggg gtttcaccat gttaaccagt ctctaactcc tgacctcagg tgatcctcct
|
55081gccttggcct cccaaagtgc tggaattaca ggtgtgagcc accaagccca gcctcaaact
|
55141cctgagttta agtgatcctc acacctcagc ctccctgagt gctgggatta caggtgtgag
|
55201ccaccacacc cggcctgagt cgggggaggt gtctatttta gtctgagtgg tcaaggaagg
|
55261cttctctgaa gagctgatgt tggggccagg cctcctcaag cgattagaag gtgtcagcca
|
55321tggggagatg tggagggagg gtgtttcagg ccaaggaagg gtaagatcaa ataattcagg
|
55381gatctgaggg cagaggaatc tggactccag ttctcccatt cagggctgcc caggagagac
|
55441aaagaggatc tcataagggt gtgtggcttt gtggctcact cacgcccaca gcaaggacca
|
55501tgcccaccct actttttttt ttttccccaa gtctccctct attacccagg ctggagtaca
|
55561gtggtacgat cacggttcac tgcagtcttg acctccaggg ctcaagtgat cctcccacct
|
55621cagtgtcctg agtagctggc actacaggca tgcaccacca cccctggctc attttttgat
|
55681tttttggtag agacggggtc tcactgtgtt acccaggctg gtctcaaact cctgggctca
|
55741agcgatcctc ccacctctgc cttctgaagt gttgggatta caggtgtgag ccaccatgcc
|
55801cagcccgcca ccagtcttga ctctccatcc tccctccctc cctgtgagtg ctggtggcct
|
55861gtgtgtcccg cctgctgaaa gatgcctctg acttggggct tttgacttca ggcccgggag
|
55921acacattttg gctggattag ggagatctta aaagggggta ggggacacag caggggctaa
|
55981ggagagtgac acactgcagg caggggttgg gtgacagatg aaggatccac tggtatatgc
|
56041tgccagtgtg tgccatctac ttgtgtgttt tacgtgtgtc tggtgcatgt gtcctgtgtg
|
56101ggctgtatct gtgtgtgact cagctacgtg tcagcatatc cctgtcgacg tgtgtctctg
|
56161ctgatgtgtc tgtctgcacg cacggctgtc ttgcatgtgt cttttttgag atagagtctc
|
56221gctctgtcac ccaggctgga gtgcagtggc acgatcttgg ctcattgcaa cctcaacctc
|
56281ccaggttcaa gcgattctcc tgcctgagcc tcccaagtag ctcggattac aggcacatgc
|
56341taccacgcct ggctaatttt tgcatattta gtagagacgg ggtttcatca tgttggccag
|
56401gctggtctcg atctcctgac ctcaggtgat ccacctgcat cagcctccca aagtgctggg
|
56461attacagaaa tgagccactg tgcctggcta gacatgtgtc tttttttttc ccttctgtat
|
56521ataacagggt ctcactatgt tgcccaggct ggtctcaaac tcgtggcctc aagcaatcct
|
56581cctgcctcag cctcccaaag tgttgggatt acaggcgtga gccactgcac ccggcttgtg
|
56641tgtgtctttc tgtatctgtt gtgtgtgtct gtgggtagtg gctgtttccc tgcatgggac
|
56701attgtggtaa atgtggctaa ttccctgtgt gggggctgct gcctgtggat aagactgtgt
|
56761ctctgtgcat gcgcacgtgt gtgcacgccc ctcacaaccc caacgagaaa acacctgtcc
|
56821accttcctgg gctggcacag gggcacagga ggcgggatcc caaatcacag gctttttctc
|
56881tcggcatatc tctgtacttt attgtccctg ctgtaacaat gctcatcctt cctgagagcg
|
56941tctcctgagg gggcctcggc caaggctgac tggagaaggg gctggtgacc cctagcaggc
|
57001tctgccacct gaggcctggg tcttcccccg ggatccttga atctggagat ggcagagagg
|
57061aggcaggccg gctctttccc caatcctcct aggagagctg cttctgccca ttctcccact
|
57121ggtgaaacgg aggcagaagc agcagctcag cagggtgaag ctgggtttaa ccttcctgaa
|
57181Yggggtccag ggacactcca catctgccac atagcctctt gggctggaca tttttcctgg
|
57241gcaccagcca gcagctggag cagcgagtgc cgtatttctt gtacctaggg ttgggggaca
|
57301agaaactgcc atttaggatg cagtgggggc ccggaaaccg ccacaaggaa accacttttc
|
57361ccaagaggta ggtgttttgc tttttgcttt ccccacaggc catcctggtt acacgtggac
|
57421tgatttgggg acccccgccc caactccctc ctccattcta aggacctgat cccacaggcg
|
57481ttgcagagag gggtcccatc ttcagcgtct ctccagagcg gggtcctctg ggtccgacag
|
57541gaagcacagc gccggggctc tgaagggtca gaggtcaaag ggcaggggtc agaggccaag
|
57601catgtgagct cgggatgcct gtgcggagtc gggcattttg tgggggtctc agtaaaggcc
|
57661ccacctagct ctggatcagc cctgggagtt gccagctcta agccacagca aagccaggaa
|
57721gggagacaga tggcagcatt ccgcagagga ggaagctggg ggtgggggtg actcagccca
|
57781agtggagggg ggtgctgcga ctcctccctg agggctctaa atggggaagc aagatggaga
|
57841aggggggggc agggagaaag gcagggaaga caggaaattg gcccccaaaa tatttatagc
|
57901tcttgggttt tcaggactca cccagggcct cgctgcctgc tgagtgggcc tcggtgcctc
|
57961ctgggtgggc tgcagggccc ccaacagcat ctgcagggga ttcctgagaa cggctactgc
|
58021agggcaggct gtggggcaga caaggtatta gcactggggg ggatctgtag cttgtcccca
|
58081acagccctcc gaaatgaaga tttagtatca aggtatcagc catcccccga ggaggcaact
|
58141aatatctgaa tggcctggct ttgcctctca ttagtaatat tattattatt attattatta
|
58201tttttgcaga tggagtctcg ctctgttgcc caggctggag tgtagtggtg tcatctcagc
|
58261tcactacaac ctccacctcc cgggttcaag caattcttga gcctcagcct cccaagcagc
|
58321tgggactaca ggcgcgcgac accacgccca gctaattttt gtatttttag tacagacggg
|
58381gtttcaccat gttggccagg ctggtctcga actcctgacc tcaagtgatc cacccacctc
|
58441ggcctcccaa agtgcaggga ttacaggcat gagctaccgt gcccgaccta attattatta
|
58501ttattatttg aaaaatagta agcacaggga cagcctgcca ggttccaatc ccagttctcc
|
58561atgtccttgc tgtgtgagcc tggacacatt atctcctact ctgtgcctca gtttcctcat
|
58621ctgtaaaatg ggcttcccaa tacaacagtt tttttttctt tgaaaatttg atttattgat
|
58681ttttaaaaag agatgggagt ctgggcaata tagggagacc ccgtctctac aaacaaaaaa
|
58741aatagccagg agtggtggta caggcctgca ctcccagcta gttgggaggc tgaggaggga
|
58801ggatggcttg ggcctgggag gtccaggctg cagtgagcca tgattgcgcc actgcactcc
|
58861accctgggtg acagagcaag accctgtctc aaaaacaaac aaacaaacaa aagcaaaaaa
|
58921aagcagccag gcatggtggc ggctcactcc tgtaatccca acactttggg agggcaaggc
|
58981agatggatca cctgaggtca agagatcgag accatcccgg ccaacatggc aaaaccccat
|
59041ctctactaaa aatacaaaaa ttagccaggc gtggtagcag gcacctgtaa tcccagctac
|
59101tccagaggct gaggcaggag aatcgtttga atccgggagg cagaggttgc agtgagccga
|
59161gattgtgtca ttgcactcca gcctgaacga cagagtgcaa ctccatctca aaaaaaaaaa
|
59221aaaatattgt tttggcggca tgattaaaaa agtcataatt ataattttta taataacaat
|
59281aaataggtaa aaattagagc tgggggtcat actatgttgc ccaggctggt cttgaactcc
|
59341tgggctcatg caatcctccc accttggcct cccaaagtgc tgggattaca ggtgtgagcc
|
59401accaggccca gcttcccaaa gctttttttt tttttttttt aaggggatgg agtcttgctc
|
59461tgtcacccag gctggagtgc agtggtgcca tctctgctca gtgcaacctc cacctcctgg
|
59521gttcaagcga ttctcctgcc tcagcctccc aagtagctgg gattacaggt gcccattacc
|
59581attcccagct agtttttttt ttttttttga gactgagtcc cactctgtgg ctcaggctgg
|
59641agtgaggtgg cgctatctct gcttactgaa gacttcacct cctgagttca agcgattctc
|
59701ctgcctcagc ctcctgagca gctgggatta caggcaccca ctacaacgcc cagctaattt
|
59761tttgtatttt tagtagacat ggggtttcac tatgttggcc aggctgatct caaactcctg
|
59821acttcaggtg atctgctcgc cttggcctcc caaagtgatg ggattatagg cgtgagccac
|
59881tgtgcccggc ctccccaggc ttttgaatga gcccatacac ataaaatact gcctgttaac
|
59941ctcttattgt tgtcactacc aacaaatagt agctgttagc attattggga aaaatcaccg
|
60001cagccgcagc tgcagcctaa gcaaggccag gcctgattcc taaagagacc aggtctcaca
|
60061ttgggagtgg ggagccactg agtcaggagc ggcaggactg tatctggcac cagctcaagt
|
60121tgtcaaccag agactgggcc acgtgtaacg tagagcacag gtgagggtcc acaccgacgc
|
60181cagRgagcac ccctacctcc cacactggtg tttgcgttgt aactgggaga aagggcggcc
|
60241tggccccagc cggcccctac ctgtacgtgg ggatgatctg caggctggag tccggcttta
|
60301tctgaaactt cagagtcacc ccctcgaacc cagggtccac tctctcggtg ccccggcagg
|
60361ggttcagctg tttccggggc cttctctggg gtggggccga gggagtcccc gggggctgca
|
60421gacggcggcc cttttggctg atcctggtct gtgtgtcctt ggaatccctg tccagcagca
|
60481ggcggccctg agtccccaga gccatcgggt cccagcaagg ccccaggacY ggggtgtcct
|
60541gggcagggga ctgacccagc ctctccactg tctcttggag gaagcacagg gcggtgaccg
|
60601actcctggca tgcaggccag agggacctgg ggagaagggc agtggggtca cgttttcttg
|
60661ggtgactcct gggtttagcc ggccaggggg ttccaacttg ggccggctct ttgtgtaccc
|
60721ttggacaggc tacacacccc acctgaggtt cagtcatttc taactctggg tggaaggttt
|
60781aagagttgca gtaattgcaa ctcacctcgc ccactgtggg cctcccaggc acgcccagcc
|
60841ctccacatca atcaacccct tacggcaccc gtagatcacc caggcaggga ccgccctagg
|
60901tgaccgaggc aggatatcaa gcctctggct gcaggatcga gaaaaaggtt actttttttc
|
60961tttgtgtttc ttttagagac cgagcctcac tctgtacccc cgcctggagt gcaggggcgt
|
61021gatcaggact cagtgcagcc tagaactcct gggctcgacc gatccttccg cctcagcctc
|
61081ccgagtagct gggacttaca ggcacgcgcc accacgccgc tggcttgcca taatatgatt
|
61141acgattttta tcattttcat tattattgag ttgccctcca taacccctgg atgatccctg
|
61201gggagtgcct acatcagccc cagagacatg gaattgcatg gcctctgatc cctagatgac
|
61261cccaagtgtc tctgggcacc agaacctctt tgtaagtttc agtaactatt ataaaattgc
|
61321cacttctcga taaccccagc aaagagaggt catRacccct tgatcactga gccaggtggt
|
61381gaagtgctag cggggtccgg ggaatggggt ttggccttac gcacctctca ctgattctgc
|
61441agcatcctgg ggtcctcggc ttctcctggg agggggatcc tcccagccgc tccaggttca
|
61501gacagggcgg cgccagaagc tttgctggca ttgaggagtc cgggattggc tcggcctcca
|
61561ttgcgcccca gcccagcccc ctccctaatt tcacccggcc ctgtcccgct gggcccaccc
|
61621gatgaaaccc acctgggagg ggcgggacct gtgtggtggg agcgctcttg gtagaggatg
|
61681cgatgagccc cagctgagag cgaccagcct cggcggcacc tttcctcttt ctggcttttt
|
61741tcaggtcatc cgcgcacccc tgcgtggcaa gggcggcctg gaccccacca aatccctccg
|
61801cagctgccgg ggcggggcct tccacgctag ccctccccct cggaaatggg ggctcccagg
|
61861cctctgcctt ggatccccag cggcatctta gatcccagag ggaaaagaga accgggggcc
|
61921cagcacagca gatgcaggtg tggtttgttt ttgtttttgt tttttttttt tttgagacag
|
61981ggcctcactc tgtcacccag gctggagtgg aatggcctga tcaccgctcc actgcagcct
|
62041aaatcccctg ggctcaagtg atcctcccac ctcagtctcc cgagtagctg ggactacagg
|
62101cacttaccac cactccacgc taatttttac tgtttttata gagacgaggt ctcgccatgt
|
62161tgcccaggat ggtcttaagc tcctggcctc aagtgatcct cccatcttgg cttcccaaag
|
62221tgctaggatt acaggtgtga gccacctgta gaccccagat ctgtccccca aggacactca
|
62281acatgctggg gcctgtgtta tcgatttatt gcagctccaa tatgagtcca ctcctactca
|
62341aaccctgatt ctcaggggcc tggggaaggc caccccacta ggggccctgt ceccaccaga
|
62401gcctggacat gggactctct cccaagcagg ggtgttgtcc ttcacagggg cttccacgtc
|
62461tctcccgggc ctgtccgcac tctgggcagg gctggcacct ggctattccc tcaatctggg
|
62521ccctggggcc atggcaatgt ggaatggtcc aggtgttcat gtcagtgggg cttggggaca
|
62581tggccatcca cgtagaagtt cctggtgatc ttgggMaggg tgaattccgc tccttccagc
|
62641tccggtgtca gcacaatctg gcagcccagc cgcgagttct cctggaggag gggggccatg
|
62701tctagcatgt cgtcttccct agggtggtga cacgggcagt gttagccgag ggcaagctag
|
62761ctgggtgggt ggggggccag aggtSgggga gggaggaagc tgactgagcg cagggggtag
|
62821tggtggggga ggcagctccc attccaggaa ctggaagtgg ggaggatggt gggggctgct
|
62881gaatgctcca gggtgaagct gccagctaga cagggctgac ccactcacct ctcctcggga
|
62941ggaggcagga gatccaggtg gtcttcactc acatacacat ggcaggtgga gcaggccagg
|
63001gaggcttcac aggcccctag gggtgggaag tgaagggggc gcaggtgagt ggcagagtca
|
63061ggaaggggct gctatgcgaa tggcgtagag gagtagacct ctcttccacc acgtgcctca
|
63121cgtctccctc ctgggcctgc agctccactg tgtgtaccag gcactgtgtc atgtcctcaa
|
63181tgtcctcagc tagctgttcc ccagtgtgta gggtttacaa acggacatct gggaggcccc
|
63241atttcccagg gactccctag caggctgaga tgcagaacca ttaaggagca gggacttggc
|
63301tgccaggtag ctgagagggg aaaggccagg caggctcccc gcagtctgtg agcccttgct
|
63361gtgaccctat cactgtgctg ggctaatgtg tccccacctc tccactgctc ttggaggatg
|
63421gaccggctga ctcagcagtc agtgtggtgg gggaaggaat caggcattag gattttgttt
|
63481tttttttttt tgagatggag tcttgttctg ttgcccaggc tggagtgcag tggcacgatc
|
63541tcggctcact gcaagctctg cctcccgggt tcacgccatt ctcctgcctc agcctcccaa
|
63601gtagctggga ctacaggtgc ctgccaccac gcctggctaa tttttttata tttttttagt
|
63661agagctgggg tttcaccatg ttagccagga tggtcttgat ctcctgacct catgatctgc
|
63721ccgcctcagc ttcccaaagt gctgggatta caggcgtaag ccactgcacc cggccaggat
|
63781tttttttttt tttttttgag acagggtctc actctgttgc ccagcctgga gtgccatggc
|
63841tcagtcatag cttactgcct caacctcccg gctcaagcga tcctcccacc ccagcctccc
|
63901gagtagctgg gactacatgt gcgcaccacc acacctggct aatttttttt tttttttttt
|
63961tttgaggtgg agtttcgctc tctttgccca ggctggagtg caatggtatg atctcggctc
|
64021aatgcaacct ctgcctccca ggttcaagtg attctcctgc ctcagcctcc caagtagctg
|
64081ggattacagg tgcccaccat cacgcccagc taattttgta tttttagtag agatggggtt
|
64141ttgccatgct ggccaggctg gtcttgaact cctgacctca ggtgatccac ctatctcggc
|
64201ctccctaagt gctgggatta caggtgtgag ccaccgcacc tggccatatt tttttttttt
|
64261tttttttttt ttgtagagac gaggttcacc atgtggccca ggctggtctc aaactcctaa
|
64321gctcaagcaa tctgcctgcc ttggcttccc aaaatgctgg gactacaggc atatgccact
|
64381gcaccagacc aggaattagg gttgaaagag acagaacctg aagttttctg ctgaccacct
|
64441gcccttggtc acacccccac atcctctgat cacagagacc ggtgcttggg gatcatgtcc
|
64501ctcctggcct aaaactttcc aaagggtttt cacactcaga ataaaatcca aactccttca
|
64561cttagtcttg cagttccccc atccccctca ttcattcctt tgttttcctt tgtaattttt
|
64621ttcttagaga tggagtcccg ctctgttgcc caggctggac tgcagtggcg tgatctcggc
|
64681tcactacaag ctccgcttcc cggattcacg ccattctcct gcctccgcct cccagagcag
|
64741ctgggactac aggcgcctgc caccatgcct ggctaatttt gtttttgtat ttttagtaga
|
64801gacagggttt caccatgtta gccaggatgg tcttgatctc ctgacctcgt gatccgctcg
|
64861cctcagcctc ccaaagtgct gggattacag gcgtgagcca ccacaccttg ccaggccact
|
64921tacctctact agcccggcac agtggctcat gtctgtaatc ccagcacttt gggaggccaa
|
64981ggcaggcaga tcaactgtgg tcaggagttt gagaccaccc tggccaacat ggcgaaaccc
|
65041catctctatt aaaaatacaa aaacttagcc gggcatggtg gcagttgcct gtaatcccag
|
65101ctactcggga ggctaaggca ggagaatcac ttgaaccctg gaggtagagg ttgcagtaag
|
65161ccaagatcat gccattgcag tccagcctgg gtgatagagc gagactctgt ctcagataaa
|
65221taaatgaaca aataaatcta tctcacattc caatccctgt cctagactat tggctgctgg
|
65281attccagaac agaactttag gtaggccttt cataacccct cccaacatat cttccccttt
|
65341aatgataaaa tcaggatccc tgatatattc atcccaaaag caaaccctat atattttctt
|
65401ccagacaacc cttcccaagt tggtcataat tatgtattta cctgtgggat tattgtccct
|
65461attagaccga aatggatgtg agatgacaga ggccttattt gttttgtata ttgctgcctg
|
65521acgcgcagta ggtattcata gaaaggcagc acagattagt ggctacaatg gactggtgag
|
65581tctagtattg tcactcactt gcccttagac caggtctact taacctgggg tttagttgcc
|
65641tcatctataa tagggaataa cagtctctac tactcaagtt gtcatgaaga ttcagtcagt
|
65701gaatatttat taacatggtt aaagacatat atatatatat atatatattt tttttttttt
|
65761tttttttttt tttttttttt gagacagtct cactctgtcg cccaggctgg agtgcagtgg
|
65821cgtgatcttg gctcactgca agctccacct cccgggttca tgccattctc ctgcctcagc
|
65881ctcccgagta gctgggacta caggcgccca ccaccacgcc cacctaattt tttgtatttt
|
65941tattagagac ggggtttcac cattttagcc aggatggtct ctatctcctg acctcgtgat
|
66001ccgcccgcct cggcctccca aagtgctggg attacaggcg tgagccaccg cgcctggcct
|
66061tttttttttg tttgtttgag acagagtccc gctctgtcat gcagcctgga gtgcagtggt
|
66121gccatcttgg ctcactgcaa cctctgcctc ccaagttcaa gtgattcttg tgcctcagcc
|
66181tcccaagtag ctgggattat atgcatgtgc caccacgccc agctaatttt tgtgtttctt
|
66241gtagagacag ggtttcgcca tgttggccag actagtctca aactcctgtc ctcaagtgag
|
66301tcgcctgcct cggcctccca aagtgttggg attacaggca tgagccactg Ygcctggaca
|
66361agaaatttct attattattt ttctctcaac aaattatcaa acatctgtta catcttgaca
|
66421ggcaacagat aagcatgaat aaggacatgg gtcaccaatc tcactggggg acagatgaca
|
66481aagtaggaaa caaaacagcc tggcattgtg gcttgtgcct ataatcccag ctacttggga
|
66541ggctgaggtg ggaggatcac ttgaacccag gagttcaagg ctgcagtgag gtatgattgc
|
66601atcatggcac tccagcattg gcgacacagc aaggctccgt ctcttgaaaa aaaaaaagtg
|
66661agaagtgcta tatatcatat cacactgata agacagagta actagggcat gggtacttca
|
66721gctgggctga ggggaatggg attgttaggg acatgacatt tacactgagg tctgaaggat
|
66781gagaaagagc cagaatgttt gctgggaaag cacttcagac agagggaaca gcaaatgtaa
|
66841aggccccgaa gcaggaatga gcttggttgt ttgaggaacc acaagaaagc cagtgtgggc
|
66901tgggcgcggt ggctcatgcc tgtaatccca gcattttggg aggctgaggc gggtggatca
|
66961cctttcagga gtttgagacc agcctggcca atgtggtgaa accccgtctc tactaaaaat
|
67021acaaaaatta gctgggcttg gtggtgggcg cctgtaatcc cagctagtct ggaggctggg
|
67081gcaggagaaa cgcttgaacc cgggaggtgg aggttgcagt gagctgaggt gcagtaagcc
|
67141attgcactcc agcctgggca acaagagtga aactccatct caaaacaaca acaacaaaaa
|
67201gaaagccaat gtggctagaa tacagggagg aagggggaag agaacacaaa atcctgggag
|
67261ccaggagtcc tagtgatctc taataaatgc ttaacaaata agagcttggc aacagatgag
|
67321gccatggtga ggggtttgga ttttagtcca tatttggtgg gaaaaagacg tgaagagaca
|
67381cacctRattt gtggKttttt tttttttttt ttttggacaa atgtataagg acctccttaa
|
67441ttccctctgc ccggttccta ccttccaggt ccaccccgtg gcgctgggcc aggtgaagaa
|
67501cattgtcccc gactctgcca ctcactggga tccgctggcc tgagcggtct acgaacacca
|
67561cgttcaccct ggggacagat ggaagtgcga atgccgaact ggatgatggg ctcagggccc
|
67621gggtagaatc tagggttagg aagtaggaat tgaggcttga cgcacaggta ctgaataggg
|
67681caaagcagaa gggggacctc gagatgaagc tacagggcaa gatggggacc agaggaattc
|
67741cgtgggatga ggaatggggg acttggcccc ctgcactcac acgtccccgg gccgctccgg
|
67801gccgcccgcg tcctcctctc cMgccgggcg cgagcctgga aaacacggtt cggtgagcgg
|
67861ctgcgccgag ccccgccccg ccggcatctg acggattaac gctgcccgcc ccgggcgccc
|
67921caggtacctg tcgcttgaaa ctttctggtt gtccccagcg ccaccccctc ccccgacccg
|
67981gaagtgcccc caggtctgtt ccaccaggtg cccctggcag cctgcagYag aaccctggca
|
68041ctcacgcctc cccgggccat ggaggcggcc atgacatgca tcacgtgact caccgactga
|
68101gcatgcgccg cgccagggag gcgagggaaa gcccataatc aatggaacat aagcgcagat
|
68161gtttgcttag ggcctgcggt gaccaggtgg gaagagcagg gcggaatcca tctcaggtaa
|
68221acccgcgggg ccatcccaga cctcccactc aagcccactg tttgtcccaa gaaccagcca
|
68281actctgattt ctttaaaacc atttacttac aaactttaat tcagcaaagg tccgtgtggg
|
68341gagactgggg tggggtcggg ggaatagtcc ccttggagtg gatgtggacc cccagagtca
|
68401agggagggaa gctggtggcc cagttggctg ggggcaaggc ccagggtcac ctcaggtcga
|
68461caggtcctgc tggtgggcgg gcccagagtt tatcttcatg gagtgctggt ttctggcact
|
68521gggctggaag gaggccagct ccagggatct ggccgggggt gggcaggcag aattcaagaa
|
68581ttcatcttca acaagcgagt gacagcagag gctccgggag atgggcacaa tgtccgactc
|
68641ccacaKacag acagcagggg actggcagag aaagcccatc tctgcacgga ggcccgggta
|
68701ggagggggtg gtggggccgg ttcgccaaga tgaaggcttt ccccttctac tgtccccagg
|
68761gtggagatcc tgggtagggt ggcccaatcc ctaggccaga gctgtttggt ccatagtcaa
|
68821gctcccagag cttggcatct gtggctctgg ccagcagggc ctggggccca gcttttaagg
|
68881catcagaagg ggagggggct gcggcaggga ccccgggccc cacggctggg gtataggcca
|
68941gatgggcagg caggggcagg agacagccat gcctgcagca aatgtgggaa aaacagctgt
|
69001ttcaaaccgc aaggtgtgga atggtggccc ggacaggccg ggccttgaag gaatcagagc
|
69061tgggggctgt ccggggtggt ttgaaaaata aaacttagaa aaggaaacag aagtcagttg
|
69121tcaaagttaa aaaaaaagga gacagtctct gtatcttcac gggaggtcag ggaaacctcc
|
69181aaggcactcg aaaggccaaa attacaggag caatgaggca ggagggctcc ggagagacgg
|
69241gcacagcgga ggaggagatg gggggaggga gggagagcag gccggggccc ctctctctta
|
69301aggctgcagg gtttcagcgt ggggagcaag ccagagacat aatgaggcct ccagactccc
|
69361ccacacccct tgggctcctg gggctccggc tgattggtca gtaaagtctt tcagagattt
|
69421ttctattacc gaaagagaga aaatggttta aaaaaaacac aaaacaaaac atcagaaaac
|
69481ccaaaagcga tttggtgcag gcccttgagt tatctctggt gccagccact tagaaaatcc
|
69541tcttccgctt caggtaggag tccgcgtagt ggccgccgag gccctgggag tgctggccca
|
69601catagctgcc ttctgggctg ggctcgggcg agggcagcag gtgggcaaag ctgcgtttct
|
69661ggccgcccag tggggtctgg agacagaggg cagggcgggg cgggtcaggg gccgctgggg
|
69721ggccggggct tcccagccct gcatgtcccc accccctgcc cgtaccttca gcaggtggct
|
69781gtgaccatta ggcccggggc tgaggcccag gagcccttct ccggacccca gcggggaaga
|
69841gccgattgcc tgggagaaat ggagaggtgg aacaggtcac tccctggggg ccagaggaag
|
69901cacccacccc gcccccctgc cactgccccc cagccctgag ggaaagcgaa cagtttcagg
|
69961ttcaaatctt gcttctgcta ctttctagct ataagaccta gggccaattg ctccatttta
|
70021tttgagcctc ggttttctca tctgtcagat ggggccagta gcacccacag cctgggctgt
|
70081agagagagga agtgacagaa agcccggaat gctggcagtg ctaggtgctt gatgcagagt
|
70141ggatggagga caataggctg ttgctactcc accctgagca agaccaaccc ctgccaccac
|
70201cccagctttg gcctgggcac cgagggttac agagccccgg tggcaggcac ccccaaatcc
|
70261tagctgtccc agggggcctg tgcttggcca gagaggttcc tcaccttact gaggtggctc
|
70321tgcttgaggc cagcctgcag gccgctggtg aagtaggaag tgggcgagcc tgaatagaag
|
70381tgagacaggg ggcccccgcc actcccaccg ctgctccgtt cgccgaagcc actgggcggg
|
70441ggggacatct gtagaagaag ggccggtgga gtgaagcaga caattgtagt acccagccct
|
70501ttgtatacaa tcttccctcY gcctcccagg ttcaagcgat tctcctgcct cagcctcccg
|
70561agtagctggg attacaggca tgcgccacca tgcccagcta attttttgta tttttagtag
|
70621agacggggtt tctccatgtt ggtcagactg gtctcacact cacgacctca ggtgatccgc
|
70681ccacctcggc ctcccaaagt gctgggatta caggcgtgag ccaccatgcc cggcagttct
|
70741gggctttgca aagactagct ttggctaata ggactgagga gagctggcac gtgggtaccc
|
70801gcctcctctt cctcctccag gaacccaggg atcatcaccg cacgaatggg cacacagaaa
|
70861ctgttccagc ctgtggacgc caaatatgtg aggccacata gctcactgag acccaggtga
|
70921gtgccgggga ccgcccactg ccccatagag tggcaagaag taataMaatg cctggcatgg
|
70981tatggtggct catgcctgtg atcctagcac tttgggaggc caaagtggga ggattgcttg
|
71041agcccaggag tttgaggcca cagtgagcta tcatggagcc actgcactcc agcctgggca
|
71101acacagtgag atcctgtctt aaaaaaaccc acaaagaaca cacaaaatac aaggtctgct
|
71161gttccaggct actaagtcat ggcacagcct gtcatgtagt aaaagctgat tgctacacat
|
71221gccataccag gtggctctta ccttgtgtcg gctgggtccg tgaggcccaa gggctggttc
|
71281ccgtgggtgg gagaagagcc gccgaggtcc catgtcctga atgaaagcgg gagaagcaca
|
71341ttgggttgga gtctgtccca gcctcacccc tggctgaact ccatggcaga gctgtcatca
|
71401gggaagacag tccccaccac tctgggacca ggaagaggca aatttggggc tggatgcagc
|
71461ttggcaggga tggctgctgt gaaggggggt gccccccatg ggcctaagtg tttggagttt
|
71521cccaggcaag ctgggaattc gagctgtgtg gactcttgca gttttcctgt gttggcgtta
|
71581gttcctgttg ttatttgttt gaaacacaga gggggccaaa catcacccag gtgacctgtg
|
71641ggcggccagt ttgcaatttc tttctttttt ttttttaaac ggagttttgc tcttgttgcc
|
71701caggctggag tgtaatggca caatcttggc tcaccacaac ctccgcctcc caggttcaag
|
71761tgattctcct gcctcagcct ccctagtaac tgggattaca ggcatgtcta ccacacctgg
|
71821ctaattttgt atttttagta taaaacataa attatatttt atattatata tgaaatatat
|
71881attttattat atattttata atatataatt tctccatgtt ggtcaggctg gtcttgaact
|
71941cttgacctca ggtgatctgc ccgcctcggc ctcccaaagt gctgggatta taggcatgag
|
72001ccaccgtgcc tggcccagtt tgcaatttct gacctgccaa ggaggttggc atcatagaag
|
72061gaccaaatct ccaggggcac agacaggaat caaaggtggg agagagggat agaaagggca
|
72121agccctgtct ctggggagag acagtgtggc ctaagtcctc ttgggagaga aagacagacg
|
72181caggatgaca gacagactga gacccaagat cctccagggc tcgagaatgg acagacaggc
|
72241aggtggaccg gaagcagggg gtgatgtgca gacagacggg aaactttaag ggcatgaggc
|
72301tgggcgcggt ggctcttgcc tgtaatccca gtactttggg aggctgaggc gggtggctca
|
72361cttgaggtca ggagtttgag accagcctgg acaacacaat gagactccgt ctctaccaca
|
72421aatttaaaaa ttagctgggc atggaggtgc Rtgcctgtgg tcccagctcc tcaggagact
|
72481gaggtgtgag gatcgcttga gcccaagagg ttgaggctgc agtgagctat gatcgcacca
|
72541ctgcactcca gccagggcag cagagggaga ccctgtctct aaaaaaaaaa aaaaaaaaaa
|
72601gcagagacca tatctggcac gttccctgcc gcctccctag cacatggcct ggcatagtca
|
72661atcctagaga aatatcagtt tggagaatga tttggcctta ggggacagag agctgcagcc
|
72721aggcactcac cgaggggtag tcgaagctgt agctgtcaga cagtcctggt tcggggggca
|
72781ggcgggcgct gctgaggggg ctgagcaggc gggacttgag ctggaaggct ttgctgctgc
|
72841tgctgccacc tccaggggct ggggggttag ttggggggcc ctcagctggg cggcggcttc
|
72901tcccggcgcc tccccagccc cgggcctcct tacccgccag gttgctggcc gggagcaggc
|
72961tgtgtaggtt caggtaggga ttcaggggaa tccggtagtc cttggggggc tcccccagca
|
73021gtgagacctg tggcgggaag gcaggattcg agagggcccc cgggagaggg aaccctgcgg
|
73081aacaggaggc tggtgtggtg ccgcgcgcag ggcagggcct taccccaggg ggcgtcggca
|
73141gaggcccact gtctttctgg aggcctctga ggccagagcc tcggagcccc acaggggcKg
|
73201ggggaggagt gagctgggcc gctgggggac ccaagcccag ggcctcccgg tcacccccag
|
73261cagggccaag cacggatggc agcaggggtg gtggcttccc tcgccggggc ggcagctccg
|
73321ggggcaggcc ccctcctagg gagggaagga ggatttcagg ggcccaggct cacaggaccc
|
73381ctctccccag ggccctccag ctcccacctg gaccagggcc caggggtcaa gagacaaatc
|
73441catgctggcc actgagcaga gctcatccct gggccctgag tggagggcac ccaactgatg
|
73501gacaagggcg ctgggaccca gaggttgggt cactcacccg aggccacgta gcagggaagg
|
73561aaggggaagt ggctggggga caccgtgtgg gcagggtctg cgttacctgc aggcagctcc
|
73621ccgaggaggg ggttggctgg ctgggcccca ggctggaggg cgcccagggg tgagtctccc
|
73681aggatgccgg gcttctaggg acagagcaca gacagttgca gatgggggca gggtggccca
|
73741gggaagcaga caggtgtggc ccagagtctt ggcagacaca ccccaactcc agggcacggc
|
73801cgatcctggg cagacaggca cagggttccc cagtgcccgc cacactccaa ctctatcact
|
73861gtcccatcag ccatggtgac cgagggtctc ctgagctcca ggccccagtt ccctggccaa
|
73921tgattgcagc acagtatcaa ctgcagccac atggaatggg acagccacac agtgtttcag
|
73981ccacttttag tcacagaagg ccagacccac aggctcacat attctgtcag ttaccaccag
|
74041acagacacac ctgacttaga atccagggaa ccacaccaga caggacggag catgggtgta
|
74101tgtctatgtg tgtgtgtgtc tgtgtgtgtg tgtgcgtgta tatctgtgtc tttgtttctg
|
74161tgtgcatgag tctgtcttgt gtctatatgt gtgtctgtgt ctatgtgtgt gtctttgtct
|
74221tatgtctttg tgtgtctatg tctctgtgtg tatatttgca tctttgtatg tgtgagtcta
|
74281tatgtatacc tgtgtttcta ggtgtgcgtg tgtgtgtgYg cacacactga ggggatagac
|
74341ctggagtttt ttcccaggca tgtctataga gcttccgagc agagtctatt cacaaactgg
|
74401tgcccagcag cggcgctccc agcccacacc cagtttcagg ctgtaaatgg gcgtgtccag
|
74461gtcccctgac cccaccccag gcaccaagtc caggggcgct ctcagaatgg agggaaagat
|
74521ggcgaaccat catgagcaat tgccagaggg ggatggggat gtgggtggga aaggcagggg
|
74581tttgggggag tcgccctcac cctggttctg cgcccccagg gcacagccag aggtcccccc
|
74641accccaccga tcgcaccagc tgtgttgaaa agagcctgta ggggctgtag agcagtgggt
|
74701gagggggatg cgtgtgttac cttctggccc tgggtctgca gggcgagctg caacagcgcc
|
74761gtggacaggg ctggcccatt gagcagcggc atggctgggg gggcacccag gaggcctgga
|
74821gggagacata ggaggatgtg tgggggtccc tgtgtcctcc ctgccccacc tcacgaaaca
|
74881cagccctgaa cccattgatg gggcaggaaa ctgacactct ggggccgggg ggtgggcagt
|
74941ggacttgccc aaaggaaggg cctagaaggg gcagaggcta ctccagtgaa ggtcagcccc
|
75001ctcttgtcag caccccacct cactgcaggc tgctgtgtgg ccctggtccc ggcccccagt
|
75061tgtggacagc agcagccccc gctatgactc catactcccc ctcggcccta ctcctggggc
|
75121tcctgtcact gcagccaaga tgagcagttt cgggaagtgc cgggggcagc gctgcagccc
|
75181ctgttctgca cagtggggcc cctgtccagc cccaccttac cctgcttccc ccccgcactg
|
75241ccatggagca gggggttgag cagcagctgg agggacgcgg atgggcccag gttgttgagc
|
75301agctgcagga tgttgggctc ggggaggagt cccttccccc gattgagggc ctgcaggaag
|
75361gaacagaagc agctcagagt gccgctgggg ccctgacatc cccatggggc tcccatcccc
|
75421accccgccac ctctgcccgc acaggctcac cgtggcctgg gcagcgatga gagcggccag
|
75481catactgcgg ccggggggcc caggggcgca gaaggagact cgcaggtggc tgccccccag
|
75541ggacaggccg tccgcctgct gctgtgcctc ctccgccatc tcagccgtct catactccag
|
75601caccgcgaag cccttcagct gcccatcctg gccgcacgcc agctgccgga ggaaggcagg
|
75661cagtcatgag catctgggca gcagtgactg caccaccccg ggaagtgaca accgtaacca
|
75721gactcagctg ccccataagg gtgaactcca cgccaggcct ccactgccct gtgcctcatt
|
75781cctgcatcag ctcatctgat tttcccaatg accctgggag gctgcatcat acccatttct
|
75841cagagaaggc aactgaggca cggagaggtc agcgcaccca aggccacaca gctggaggga
|
75901gggcggagct gggagccacc tcaccaacaa agccaaggcc acgggcggat gcggtggctc
|
75961acacctgtaa tcccagcact ttgggaggcc gaggcgggca gataacctga ggtcgggagt
|
76021tcgagaccag cctgaccaac atggagaaac cccgtctcta ctaaaaatac aaaattagcc
|
76081aggcgtggtg gcacatgcct gtattcccag ctacttggga ggctgaggca gaggcaagag
|
76141agtcacttga acctgtgagg cagaggttgc ggtgggccga gatcgcgcca ctgcactcca
|
76201gcctgggcaa caagagcaaa actccatctc aaaaaaaaaa aaaaaaaaga gataatcagc
|
76261aacgggtggg gaaggaaggg ctctcgttcc agacagtggc caagccaggt agcagtgcta
|
76321agggaagtgg ttgggctggg caccggcact tgctgaatgc ccgggcagca aaggtgcagg
|
76381tagcagccct tcacctctgc ccacgccctg tgccaaggtc tgggcacaga tctcccataa
|
76441ccaaacctgt cggcttttgt tttgttttgt tttttttgag acagagtctt gctctgtcac
|
76501cccggagtgc agtgatgtga acttagctta ccgtaacctc cacctcctgg gttcaagtga
|
76561ttctcctgcc tcagcctcct ggtagctggg attacaggtg tgcaccacca cgcccagcta
|
76621atttttgtat ttttagtaga aatgaggttt caccatgtcg gcaaggctgg tcttgaactc
|
76681ctgacctcaa gcgatccgcc tgccttggcc tcccaaagtg ctggattaca ggcgtgagcc
|
76741actgtgcccg gccataaaca cacccatctt agggatgaac agagagagac tcagaggggt
|
76801cacagagtga tcaaggccac acaattccta agtcgaggga ctgatgtgtg aacctcaagc
|
76861tgcttcactg tcaagcccac cctccattca gcYgggtcac ctaacattaa aggtgggctc
|
76921ctcggaggac atcacttcaa cgcctgctac tcatcagatg ctcaacaaat gtttggtgag
|
76981accaggccca gtggctcgaa tctataatcc cagctctttg ggaggcaaag gcaggaggat
|
77041cgtttgagca caggagtttc agaccagcct gggcaacata gggagacccc atcttcacat
|
77101aatttttttt ttttttgagg gagtctcgct ctgttgccca ggctggagtg cggtggcatg
|
77161atcttggctc actgcaacct ccacctccct ggttcaatca attctcctgc ctcagcttcc
|
77221cgagtagctg ggattaaagg cacctaccac cacgcctggc taattttttt tctattttta
|
77281atagagacag ggtttttgtt ttttgttttg ttttttttga gacggagtct cgctctgcca
|
77341cccagactgg aatgcagtag tgggatcttg gctcaccaca acctctgtct cccaggttca
|
77401ggtgattctt ctgcctcagc ctcccaaata gctgggacca caggcacatg ccaccacacc
|
77461cagctaattt ttttttttgt atttttaatg gagatagggt ttcaccatgt tagccaggat
|
77521ggcctcgatc tccagacctc gtgatgcacc cacctcggcc tcccaaagtg ctgggattac
|
77581aggcgtgagc caccgtgcca tgagacaggg ttttaccatg ttggccaggc tggtttcgaa
|
77641ctcctgacct caagtgatct gcccgccgca gcctcccaaa gtgctgggat tacaggcatg
|
77701agccactgtg cccggcctct acataaaatt ttaaaaatca gctgggcatg gtgaYgcatt
|
77761cctgtagttc cccagctaca tgggaggcca aggtaggagg atttcttgaa cccaggaggt
|
77821cgaggccgga gtgtactcct ccagcctggg tgattgagaa cctgtctcaa aaaaaaaaaa
|
77881aattaagttt agtgaatgtt cgagtggagg aatgaatggg cagctgttca caacaacctg
|
77941atcatgaagc actgccagcc ccattttgag atgtggaaac aggctaggag agtacctgta
|
78001gctggtcatg accctgtgac ctttgatctc cacataagaa ggtaaggcca ggccagcgca
|
78061gtggctcaca cctgtaatct cagcacttgg ggaggccgag gcaggtgtat cacctgaagt
|
78121caggagttca agaccagcct ggccaacacg gcgaaacccc atctctatta aaaacacaaa
|
78181aattagctgg gtgtggtgtc aggcgctgtc atcccagcta ctcgggaggc tgaagctgga
|
78241gaatcacttg aacccaggag gcggaggatg cagtgagcca agatcgcgcc cctgcactcc
|
78301agactgggtg acagagcaag actctgtctt aaaaaaatat aaaataaaat aaaagaaagg
|
78361tgaggccatt gtgctaactc atcttctgtc ctgagcccgc acaggcggcc tggtacatag
|
78421caggcctggt acgtagcagg tgtccaagag aaagcagcag aatggatgaa tgataagtaa
|
78481acagagaggg ggttcccgtg gctcatggat actcagtttt tgtttttttt gtttctttga
|
78541gacggagtct cgctctgtcg cccaggctgg agtgcagcgg cacgatctcc actaaccgca
|
78601accgcagtct tctgggttca agcaattctc ctgtctcagc ctcctgagta gctgagatta
|
78661caggcgcgtg gcgccatgcc tggctacctt tttttttttg ttgtattttt agtagagacg
|
78721ggatttctcc atgtttgtca ggctggtctc aaactcctga cctcaggtga tccgtccgtc
|
78781tcggcctcca aagagctggc attacaagcg tgagccactg cgcctggcct gttttttttt
|
78841tttttttttt ttctgttttt gagatgcagt gttgctttgt cacccaggct ggagtacagt
|
78901ggcgtgatct cagctcactg caacctccac ctcccaggta caagcgattc tcctgcctca
|
78961gcctcctgag tagctgggat tacaggcctg caccaccaca cctggctaat tttttttgta
|
79021tttttagtag agacagggtt tcaccatgtt ggccaggctg gtcttgaact cttgacctca
|
79081agtgatccac ctgcctcggc ctctcaaagt gctgggatta catgcatgag ccacctcacc
|
79141cagcctgttt cttgttttaa atatagagat ggtgtcccac tatcttgccc aggctagtct
|
79201tgaactcctg gtctcgagtg atcctcctgc ctctgcctcc caacagacac ctagtttaaa
|
79261tggggcacca ataccccact tacacgagag ggacccactc aagcccacag agctgggggt
|
79321ccgagcccag gactgtctct ctgtttttga gatRagggtc tagctctgtt gctcaggctg
|
79381tagtgtcatg gtgctgtggt gcgatcatgg ctcactgcag cctcggactc ccagaatcag
|
79441gcaatcctcc cacctcagcc tcctgagtag ctgggactac aggcacacca tcatacctat
|
79501ctaatttttg tatagagagg atttcaccat attgcccagg ctggtctcga actcctgggc
|
79561tcgagggatc cgcccgcctc agcctcccaa agtgttaggg ttacaggtgt gagtcactgc
|
79621acctggccag gcctacccct tttaagcctc tgcactggcc tccgctcact ggcccaagct
|
79681ctggagctag gctgcggtgt tctgatccca gctctgccag accctggctg tttaactcta
|
79741ggcaagttac ttgacccctc tgtgccttgg tatcctcacc tgaaaatggg agtgatacct
|
79801gcctctcagg gttgctacag gatgaagcaa ctgaaggtta cgtactcaga gtccacagcg
|
79861agtgctgggg gaatgtcccc tttgggatct ctggggatca agaccttctg ggggctctta
|
79921gagagtgagt ctggcctgtt ctcgccccac tgcacctgtt acagggcgag gcacacacac
|
79981agaagtgcct ggcatgtgtg gcttgaatga acaagggact gttttgccaa cccattgtgc
|
80041aagtattgag tccctgctta tggaggaggg aaactgcaga tcagagagcc agtgactggc
|
80101ccgagctcga gggcggggct gggatctggc aaagcctcag tctctgacct caaggctcaa
|
80161atagactgtg ggctcctctg cagcctcctc aatgcctggt ccaggtctgg gaccccatgg
|
80221gaggtttgac gagggtacca gcgaatgagg aggtgagtgg tgagcaagcc tcgagatcca
|
80281tagttacaag agtggccttg catgcatctg atagagggac agtgaggcct gaggctgcag
|
80341agggattcaa atcccctggc caggtgtggt ggctcacgca tgtaatccca gcactttggg
|
80401aggatcacct gaggccagga gttcaagact atcctggcca acatggcaaa accccatctc
|
80461tactaaaaat ataaaaatta tccaggcatg ggggcggggc gcctataatc ccagctactc
|
80521tggaggttaa ggcaagagaa ttgcttgaac caaagaggcg gaggttgcag tgaactgaga
|
80581ttgtatcact gcactccagc atgggtgaca aagtgagact gtctcaaaaa aaaaaaagaa
|
80641aaggcagatg actccaaaga ctctctcagg tgctccgggc ctggcacctg ctccccaatg
|
80701ctctccacag ggctcacctg gcagaaggtg gggctgtgga cagctgacag cgcccggcac
|
80761agagcgtcca catcgttgaa gccaggtggc aggcggtcca cacagaggca gcgggagtgg
|
80821agaagggcag gcgtcagttg cccggcatcc gtccagtgca cgtagagggt gcgtggtccc
|
80881agcggcttgc ccagcaggtc Ygacttggca cgggcagccg agtccttctt catgtactcR
|
80941gcaaagccat agcccttgga ttggccagtg cgctcactgt agaccaggaa gcagcgctcc
|
81001aggctgccga agggccgcac cagctcctcg aactgctgct gtgtgaggct ggggggcagg
|
81061ttggccacac acagcagggc atccgtgggc tgcagctgca ccgacagttc Rcgctcccgc
|
81121aggcggctct ggtggaaagc attgattgcg gcctcggcct gctccccatt cagcagggtc
|
81181acgaaggctg cggtgggagg agggcagtgc gaggtcagcc gggccctgag ggcctgcccc
|
81241tccaccccgc caccctgcaa accaggtggg acctccaaat gctgggcatc tcaggtgcct
|
81301gctgatctga gcagttgcca gccttggcga ctcacacagg cgagagcgcc tgccattgac
|
81361tctaggctcc acgaagccca ctccctctcc cagccctgcg tccacctgca cccacagcag
|
81421cgctcaccaa ctgtgggcct ggctctgtcc taagaacgct gtgggtcact cgggtgatac
|
81481caagggcagt ggttaagccc atgctcactg gggcccagat ttaagcccca agccccaggt
|
81541ggctttgggg gtatcagttt cctcatctct caaatggata taacttaatc atcacaatca
|
81601ccattttgcc agagaggaaa cgggcccaga gcagcacccc tgtgccccga gtaggggagc
|
81661ctggacttga acccaggcag ccggactcca gaggcccact ctacacactg cccacccctg
|
81721ccacctttcc aggccaccag tgcccctgaa ccctgctgcc acgtgctgcc ccagatttgc
|
81781gatccaccca gcggccgcag gaagctttgt tcaaaacgat cacgccacat ccatcttgtg
|
81841gcttctagct gcagggtgca gtgcagcctg tgcgggctcg ctgacctccc ctcccatctc
|
81901accgctgcca cccggaccac gccaggcaca ctccagaggg gcctttgcag ctgctgtttc
|
81961ttgagcatgg aacactgagc cccacctcct cacctggtta acctggaccc acccaggtag
|
82021aaaccctgtc tctactaaaa atacaaaaat tagccgggca tggtggcaca tgcctgtaat
|
82081cccagctact cgggaggctg aagcagggga atgggctgaa cccaggaggc ggaggttgca
|
82141gcgagccgag ctcgcgccac tgcactccag cctggcgaca gagcaagact ccatctcaaa
|
82201aaaaaaaaaa aaaagaccac acaagcaggg gtgactggct gagtgaggca agaggggtaa
|
82261gaagagaatg aacccacggc caaacgttgt caagaattag ctcaatgcca agcgagtgga
|
82321gtaggaagag aatcagcccg atgcccagtg ttctccaagg agaacatgaa ggctgtccca
|
82381agatgacagg atgacaggca gattggggca acctgccatg ttggcctggg gggcaatact
|
82441gggcctgaag ctcagagcag cagacagtga gccaggccct cccatcttca gggatggtca
|
82501ctccctgccc tggcccRccc catggcccca caaacctgtc cctttgtatt tgtccacaaa
|
82561acagtatttg agctcatagt cactgagcag gtcatgtact tcctgtggag atacaagaca
|
82621aaagacaggg agttactgga gatggaaggg ggcaacccag tgccgcttca tagctgccac
|
82681cagctatgaa ggcaggtcaa ttaccacccc ccattttacc aatgaggaaa ctgaggctcg
|
82741atgcagtaat tttgtcaagg tcattctgct catacctggc agagatggga ttcagaacct
|
82801agctgcagac tgtgctatta cccaggcaac atgctcttag agggtatacc tttagctggc
|
82861tgggcggggt ggcYcacgct tataatccca gcattttggg aggccgaggc gggtgaatca
|
82921cctgaggtca ggagttcgag accagcctgg ccaacatggt gaaaccttgt ctctactaaa
|
82981aatacaaaaa ttagccagga gtggtggcgc acacctgtaa tcctagctac tcgggaggct
|
83041gaggtaggag aactgcttgc acccaggagg cagaggttgc agtgtgccac tgcactccag
|
83101cctgggtgac aaagggagac actgtcaaca acaataacaa caaggccggg cgcggtggct
|
83161cacgcctgta atcccagcac tttgggaggc cgaggcgggt ggatcacgag gtcaggagat
|
83221cgagaccatc ctggctaaca aggtgaaacc ccgtctctac taaaaataca aaaaaattag
|
83281ccgggcgcgg tggcaggcgc ctgtattccc agctactcgg gaggctgagg caggagaatg
|
83341gcgtgaaccc gggaagcaga gcttgcagtg agccgagatt gcgccactgc agtccgcagt
|
83401ccagcctggg cgacagagcg agactccgtc tcaaaaaaaa aaaaaaaaaa aaaaaaaaat
|
83461aacaacaaca aaaaaaaaaa aaaaaaaaga ggccgggctc acgcctgtaa ttccagcact
|
83521ttggaggctg aggcaggcgg gtcacaagat caagagatcg agaccatcct ggccaggaag
|
83581gtgaaacccc atctctacta aaaatacaaa aatcagctgg ctgtggtggc gtgcacctgt
|
83641agtcctagct actcgggaga ctgaggcaag acaattgctt gaacccgagg ggtgaaggtt
|
83701gcagtgagca gacatcaagc cactgcactc tagcctggcg acagagtgag actccgtctc
|
83761aaaaaaaaaa aaaaaaaaaa aaagagtatg cctttaggga agccatttaa cctgcatgaa
|
83821cctccttttg caagattcac tgtttccaac aactctgtaa gtgaagtatt aacaaactca
|
83881tgttgtatat gagaaaactt aggctaggag aagtgaagag atctgctgga ggccatgcag
|
83941ttgggcagcg cagccaccca tgggtacctg actggggagc ccaccttcta gtaagcccca
|
84001cgttgtgtgg gttcacatgc ctcccaattt cctcctgctg ataaagctgc cctcttccaa
|
84061gccagctcat ttatttttct tttttttaga gatagtgtct tgttctgtca cctaggctag
|
84121agtgtagtag cacaatcata gctcactgca gcctcaacct cctaggctca agtgatcctc
|
84181ccacctcagc ctcctgcgta gctgggacta caggcacgca ccaccatgcc tggctaattt
|
84241ttaaaaattt tttgtagaga tgagggtttc actataccgc ccaggctagt ctcgaaccct
|
84301tgggctcaat acagcctctt gcctcagcct ctcaaagtgc tgggattaaa gggatgagcc
|
84361accatgccca gcctctcaag ccagctttga aggcaaagtg ctggcgcctg ctgggaccag
|
84421acacactgtg catcttgcag gagagacaat gtgttcccag ctgagagact gcagacactg
|
84481agaggaagac ccagaaagaa acctgaccat ccttaatgat ccctgtcccg atctgtcccc
|
84541aaattcagcc cctcccaaca tccctggggt tccactagcc acgtgcccac ccggtgtgct
|
84601ggtgggccgg agagcaggga atctcagcag caggaagcga gaacctattt caccgccata
|
84661gggcagggca gtatagatgc catttccctg ggtccaaaga gcattgggaa gcgctgcccc
|
84721atgctggccc catgagaagg gcactcctag caggaagatt agccacgagg ggctccatag
|
84781aacacaggcc tcgcttcctt cctgtaggtc tgtaggctgg tggcagaaga ccccattttc
|
84841ccaaattaat cctgaggttt tgggggctga gacccagggg ctgctgttaa cttccggatt
|
84901tatctctgag agcagtgaat aaacgcgtga tatggagggg cgtactctcc gcagtcctga
|
84961aacttctgga tgtgaggYcc cgccaccctg tggtagagtg ggtggagaaa agcatcatcc
|
85021aagcaggggg caactggtgg tccaatgtac cagcccattc acaattcccc aacaggacca
|
85081aagctgtccg cccccttcca ttccccgccc gcttccatca cttggtgtcg cccaagcctg
|
85141tggtcgcccc tagcaacgcc ctccctcact tcgcagtcgg tttccccttt catcatcgcc
|
85201cccccacgtc ccgctcttgg tctctcccga tcccgcgtgg atccggtgct tgggcgcccc
|
85261cgccaacgac ccccgcgcac ctcagcgttg gtgtcgcccg gttccccccg cgcacgcgca
|
85321ccgtggtatt tcccgccacg ctcctacacc gcccccccca atacctggtt ggtcacgtcc
|
85381cccgggaggc cccggatcag tatcttgcgg cggttacgga actggcgctc ggtgtgttcc
|
85441aggcgtttcc ggatctcttc tggatctaga ggcggcagct cttcttccgg cgcccggcgc
|
85501tccgcggcat cgccggcttc gacttcggcc ccagacttag ggctcagcgg gggccggtga
|
85561gtaacggaca cgtccgccgc catcttggga aacccggcgc cttctgggac cagcgagccg
|
85621gggcggagcg gcatagagcg gcaacgaggg cgcgcccgtc gattggctgg gagaaacccc
|
85681acctccttcc cgcccccctt gccccgttgg ctaagcccca gcccacctct caagagttca
|
85741agctgcgtct gcgcgccaca ggccccgccc ccttccgtcg cagcgacgct actcagtgga
|
85801tgtgcacctg ggtgggagag acttgcagcg cgggtggaat caaaccacag attagggagt
|
85861ttgaaggctt tattggtgcg gaatctgagg gcacagccaa gcccccgcca actttgatcc
|
85921cggatcccag cgtcactcag ctctggacgg ttcttccccc attgcttctg tcggctgcat
|
85981agacgtgagg ggcagatagg tgStctcctc cctaacatgg taactgccgc tccgttggtg
|
86041ctccctgaag acgtacatta aggccagtac gatagtcacc acgcccaggg tcagtaacac
|
86101cgccacgaag acggggacaa agtgggagct cccagctgtg cagagaaagc gctaagtcaa
|
86161tatgcgtccc ttctgtctcc aacccccccg ccccccggct taccggtcca gacccgcagc
|
86221cccgtRttag ctcaccctca atgtccatca ccacgaccag ggtgtatttg cctcgtgagc
|
86281tggacgcttg gcactgataa gtaccattat gtgttacgtt gacgaagaac gggatcccca
|
86341ccggcacctc ccggctggag ccttccttca aacaccgcag ctcggggtac gggttgcccc
|
86401tggcttggca ctgcaggacg tgtctcgttt tatctttcca tttcaagtgc tgggggcatg
|
86461tggctcggtc aattttggga ccatctgtgg aaccaccatg tgtgatcaga cacccaacac
|
86521acccgaggca cagtggtgca gaggagcgtc taatctttcc agggcagggg tggagggatt
|
86581aaaggtcagg gtgaccgact cacacaggac tcgcagctgg acgctactgt tcctgtgcaa
|
86641gaactcgccg tccacctcga gagtggcact gcagaagaag ctgcgtccgt cgtcactctc
|
86701ggtagcattt agctgaagtt gagctggctg ccccggggcc gcggccggaa ctccgtccag
|
86761cgtgacctgg actcgagccc cagccatgca actcacggtc actgtggacc cctcatgggc
|
86821ggtgggctcg ctgaggttca caatgggtcc taggaagcct aaaggcgggg cattgcccag
|
86881gagcttaatg aacaggacct tcctgtgggt caagccgctc cctccgccct cccctttcct
|
86941ctcgggatat ccgggccacg ctttcggccg ttcaagcctc gccctctttc cgcgctgtgt
|
87001ccagcttcgg gcactcaggc ccaacccacg ttgcaactgc tattggggca agccaggccc
|
87061caccttttcg gctagtctcc gccccctctg ccacgccccc agactgctga ggccgcgccc
|
87121ccttcccacg cctcctctta ctaaagaccg tcaagttctc ccgggcctcc cgtctctcgc
|
87181cccctagggt cacgttgcag acgatYtccc gggcaccctc ctgatccgcg cgcgccgtgg
|
87241ctgtggctgt ggccgttagc gtgtccccgt ggttcatgac tgtcgcattc agcatctggt
|
87301cccccagcgc caggtagacc tgggcctctg aggctggaaa aagcccgtct agggtgcagt
|
87361ccaccggcca cgacgtttcc acctccaaga accggggggc cacgaggcgc gggggggtca
|
87421cgggcaggac tggggagaaa ggtgggcata gtacaacccc caggactgtg ccttccccag
|
87481gacaccctca tcccccccag tcaggatatc ttgctgactg ggtcaccctt cttcRcagga
|
87541cacacacaca gggccatgaa aacggccttc ttcaaagatc ccacggctcg ggcctccctt
|
87601ccggggccac cttgcccagt ggccgggggc tttccttccc agaagcctgt gaggtccggg
|
87661gtaccccact ctcaggaacc ccaaggtcag ggcaccgtct accctggctc agctcgtcac
|
87721ccaccgtctg aagccccttc tctcaccaaa ggttcggagc tggcgggggg ctgaggtgtt
|
87781cacgaacagt cccagcccct ggggctgcat gtccagttct gtgcggcatg agaaaggggc
|
87841tccgtggtcg tctctgctgg ccagcacagt ggcagtgacc tccgctggct cctccactgc
|
87901gggctgccgg ctcagctcct cctcccagcg aagcagcacc accgtgaggc tggtccgggg
|
87961cgacccaYcc tccacttggc agcgcagggt gaagttctgg cccaccggct gccaaggagg
|
88021caggggtgcc agctccacac gctccgggag ccctgagaga ggaggggagg atggcactta
|
88081gcgggtcctg caaacccacc cactcacccc agggactggg gaggagacag ggtRgtcctg
|
88141ccgagaactg tgagctttga gttaataaac ttagagggct tagagctggg ccagtcgaag
|
88201cgtttgctat tatcattagc gcagtgatta tcatttcctg tgttgtcaga taccttgcaa
|
88261ggcgctaaac aaaactttct gttctcaaag atggcaMaat aaaaaaaaat gaggatggaa
|
88321gggatgaacg tttatgacta tgatatgaat attaaaaatt cctgtttatg gccagacgtg
|
88381gtggctcacg cctgtaatcc cagagctttg ggaggccggg gtgggtggat caaRaggtca
|
88441ggattattca gttctctcca atcaggttca gacactcagg gctttcctgg ttcaccagcc
|
88501ctgtggcagc ctctcaagat actccggcac agtcacagga gacttgacac tcccaggctg
|
88561ggtgccctcc ccagtacacc tacaaaacgc tgggcctcag gccgggcact gtggctcatg
|
88621cctgtaatcc cagcactttg ggaggccaag gtggacggat cacctgagac caggagttca
|
88681agaccagcct tgccaacatg gtgaaacccc atctctacta aaaatacaaa aattagccag
|
88741gcatggtagc acgtgcctgt aatcccagct actcaggagg ctgaggcaca agaatcgctt
|
88801gaacccagga ggcaaaattt gcagtgagct gagatagtgc cactgcactc cagcctggcg
|
88861acagagagag actctatgtc aaaaaaaaaa aaaaaaaaaa aaaggctggg caaggtgact
|
88921catgcctgta atcccaccac tttgggaggc cgagggaggc ggatcacttg aggtcaggag
|
88981tttgagacca acctggccca tatggcaaaa ccctgtctct actaaaaata caaaaattag
|
89041ccgggcatgg tgtcacacgc ctgtaatccc agctactaag gaggctaaga caggagaatc
|
89101acttgaaccc aggaggcgga ggttgcaatg agctgacatc gcgccattgt actccagcat
|
89161gggggacaat agcaagactg cgtctcaaag aaaagaaaag tcaaaaagta ggccaggcat
|
89221ggtggctcac gcttataatc ccagcacttt gggaggccaa ggcgggcaga tcatttgagg
|
89281ccaggagttt gagaccagcc tgggcaacat ggtgaaatcc tgtccctact aaaaatacaa
|
89341aaattagctg ggcgtgttgg catgcgcctg taatcccagc tactcaggag gctgaggcag
|
89401gagaatcgct tgaacccgga aggcagaggt tgcagtgagc caagattgcg ccactgcact
|
89461ctagcctggg ggacagagtg agactctgtc tcaaaaaaaa aaaaaaagaa aagaaaagaa
|
89521aaaaaaaagt agccaggcct gcaatcccag ctactggaga gactgaagtg ggaggattgc
|
89581ctgagcccag gagtttgaga ccaacctagg caacataggg agatcctgtc tctaaaataa
|
89641aggtataaaa aagtgtaaat gtaaaacctc catttgccta ctgctgactg aaaggggtac
|
89701cccctttttt gcttaagaga caagggtctt gcttttttgc acaggctgga gtgcagtggt
|
89761gcaattatag ctcactacag ccttgaactc ctgggctcaa gcgattctcc caccttggtc
|
89821ccccaagtag ctgggacttc aggcatgtgc caccatgccc agctaatatt ttttatttat
|
89881ttttgtagag acggggtgtc cctatattgc tctgcctggt cttaaatttc cggactcaag
|
89941caatcctcct gccttggcct cccaaagtgt tgggattatt gttggggcca ggcgcagtgg
|
90001ctcacacttg taatcccagc actttgagag gctgatgtgg gcggaacacc ccgtctctac
|
90061taaaaataca aaacttagct gggcattagc tggacctggg aggcagaggt cgcagtgagc
|
90121cgagattgca ccactgcact ccagcctggg ctacagagta agagacgcca tctcaaaaaa
|
90181aaaaaaaagc ttgttggggc cgggcgcagt ggcccatgcc tgtaatccca gcactttggg
|
90241aggctgaggt gggcggatcg cctgaggtca ggagttcaag accagactgg ccaacatggt
|
90301gaaatgccat ctcaactaaa aatacaaaat ttgctgggtg tggtggcgtg catgtgtaat
|
90361ctcagccact cgggaggctg aggcaggaga atcacttgaa cccaggaggc gaaggttgca
|
90421gtgagccgac atcgtgccac tgcactccag cctaggcaaa aagagcgaaa ctctgtctca
|
90481aaaaaaaaaa aaaaatgctt gttggggccc aagttaattg atttcacaac tgctgccttg
|
90541gcatgagatt gagatgcgtc tctatatctc tgtctctgtc tctgtgtctc tgtctctgtc
|
90601tRtctttgta tctcacacac aaatgtccag gtctgagctc tgggtcagaa ctgtggtcca
|
90661ttctttgcaa actgagggtc cccactctcc tgagccattg gccacttgcc cacaccacta
|
90721cccaagacca gtcccacctc cggacacgtY gactcactgt acacggtgat gttagaggag
|
90781cctgttatct gRgagccatt gcagtacact gagcagagga tccgactgtt gccagtcacg
|
90841ttgctgagat tgaaggctgc ccagcccatg ccactggcca ccagctcctt tgatagggac
|
90901gtctccaagg cgattttctc agagctggga caatcagtac tgcagttcac aaacagggac
|
90961cctccagcag agagcacagg gttctggggc tccacccgca aaaggaactc ctgcccctgg
|
91021acaccttcag gaacatgaag aagtcctggt gtttgtttcc ttgtYcccca acccacgcat
|
91081caacaggccc caccatttaa cacctctctc cttgtgccga gacagaaggg ttcctgcctt
|
91141catggtccag Kgggaaaggt agaatccatc agagaccRgg gagaactcag aaggaggcca
|
91201gaagaggctc tgatccagca taggaggagg tgagtcaggg aaggcttcct ggaagcgggg
|
91261accattgcag cccgaaactg aaggctaagt aggagttagc aagtgaaagg gacaggtgat
|
91321cctggcagag ggaagcacat acgcaaaggg caaatttcag gagttcagat ggagcaggaa
|
91381gcatgagggg tgtgtgtgtg tgtgttaggg gagagggatg gcgtacaagc ctatgctggg
|
91441gcctgaccac ctgaaggctg aactaaggaa ccagaacttt ctcccgagga tacagagtca
|
91501gcggccaggt cgcagtgtgg caggatgtga acagcgttgc gttctattcc tctaccctct
|
91561actgatcccc aaaacgcagc cctctccagc cctccccggc ttgactggtc tcacctgggg
|
91621tcagcagaca gcagaccagc agagtccagc aggccctggg ccacaacacg gatggtacca
|
91681tggtRgccat tctgacagag gaaggtgcct tcctgaggtg cccgaagggc aggcagggga
|
91741aaaggcgggg cctcccactg cgacggaagc acagcggtta agattgcaga agtctgggga
|
91801ctgcaccttg cccaggcctg tgggtggaag gggatgctgt ggcccttggg ggccagggtg
|
91861ggggacccag acggggctct gcaaagtggc cagcactgct gagtctcccc cagggaatgg
|
91921gctggtccca gttgcactgc tggcccccat ttgaattcac aggaaatgct aactaaactg
|
91981gtttcttttg ttctcagcac tgggaagcct gggtgggggg gatgaggcat ctccttctgg
|
92041ctgaacttag gtgggtaggg gaatattctg tccccagaga ggaagttaat ggggaaaact
|
92101gtaggcacca ttgtgtagat gttaaggtgg gatttcgagg aaacattaaa aaacaaaaac
|
92161aaaaacagaa acagaagcag agtcttgcta tgttgccccg actggtcttg aactcctggc
|
92221cttaagatgg cctcctctca tcttgacctc ccaaagtgtt gcgattacag gcgtgagcca
|
92281ccacgcctgg ccacctttga agatcttgag gatacctccc tatctttgaa gatcttgggg
|
92341atcccccatc ccctgcacaa agagctaagg taggtgattt ggggacagct gaKtccctga
|
92401gccactgtct atccaggatt ctacttggtt tttgtttgtt tgttttgaga cagagtctca
|
92461ctctgtcacc caggttggag tgcagtggcg ggatctcggc tcactgcagc ctctgcctcc
|
92521cgggttcaaa cgattttcct gcctcagcct cccgagtagc tgggattaca ggcatgtgcc
|
92581accacgcccg gctaattttt
Following is an ICAM genomic nucleotide sequence that includes the ICAM SNP “ICAM-AA” (SEQ ID NO:).
|
CCGTACCCTAGTTCGTTCTCAGCACCCCGAGGATTCGGGCAGATAAGGGG
|
CGGGCCTTGACCGGAGGGAGGGGTATGGTCAGTATACTACGACCAAATGC
|
TCCGCCCCCAGGCTTCCCGGCACCACTCCTGACCCTGAGCGAACCCAGCG
|
TCTCCGAGGGGCAGATGGTGACAGTAACCTGCGCAGCTGGGGCCCAAGCT
|
CTGGTCACACTGGAGGGAGTTCCAGCCGCGGTCCCGGGGCAGCCCGCCCA
|
GCTTCAGCTAAATGCCACCGAGAACGACGACAGACGCAGCTTCTTCTGCG
|
ACGCCACCCTCGATGTGGACGGGGAGACCCTGATCAAGAACAGGAGCGCA
|
GAGCTTCGTGTCCTATGTGAGTTGGTGATAACCCCTCGCCCCCCACCTTC
|
TGGTGACTTCCAAGGACCCGCCTGCT [C/T] CCTCACCGTGTCGTGGA
|
GGCGGAGCCATTTCTTACGTCTAAGCCTCTGTAACCCCAC
Following is an ICAM genomic nucleotide sequence that includes the ICAM SNP “ICAM- AB” (SEQ ID NO:).
|
GGGAAGGAGGCTCTGATAGGAGGCAGGATCCTCTTCTGCCCATCAGAGGC
|
GCGGTGGTCTCCCATCGATCGTTGTGGGCCGGAGCAGGGCATTTGATCAG
|
TGGCTGGGCCGGCGCTAAGCCCCACTTCACCTTCTGTGCCCTTCAGACCG
|
GCCAGTGGTGGCCGAACTTGCTGCCTCGCCCCCTGGAGGCGTGCGCCCAG
|
GAGGAAACTTCACGTTGACCTGCCGCGC [G/A] GAGGCCTGGCCTCCA
|
GCCCAGATCAGCTGGCGCGCGCCCCCGGGGGCCCTCAACATCGGCCTGTC
|
GAGCAACAACAGCACACTGAGCGTGGCAGGCGCCATGGGAAGCCACGGCG
|
GCGAGTACGAGTGCGCAGCCACCAACGCGCACGGGCGCCACGCGCGGCGC
|
ATCACGGTGCGCGTGGCCGGTAAGTGGCAGCTGGGGAGAGGCGGGGCGAG
|
GTATCTGAGAGGGGGCGTGACCTGGGTCTTGGGGCGGCCGGCCCCGCCTG
|
CCTCCCTCTCGGTCCCGG
Following is a MAPK10 genomic nucleotide sequence (SEQ ID NO: 2).
|
>4:87372101-87483050
1attttcccaa aatactagac agtcatatat aatggaaact gcaaacctcc gaaagtgtgt
|
61ctgcgtgtgg gcaaatagta aaatagcatt gaatacacaa tgtcttcaaa cacagtacac
|
121aagtttgaca gttattctaa ctgctctaaa attcttttta tcagattcac tgctaacatg
|
181catggaaaat atgatgacaa attcgRagat tcctaaaaga gaaaagaagg ctatataata
|
241caatcaatta ttacattgtc ttttttcaca attctgtaat aattgatggt aattcaatag
|
301atatttatct ttatctaact ttatctttaa aactatccca agtttactta ttactgctac
|
361ggttttaaat tgcagcagct gaaatatagt aggacaaatg cataatttgg aataagacta
|
421aatattgcat ttcaccttga tcacatcgtc tctgtgccct gagcaaatag tttaacttct
|
481ctaaccctca attttctcat ctgaaaaaaa aaatgaatcc tctctttcgg actttcaaga
|
541aatttaattt ggaagatata agggaaacat ttgcatctac tacagtgttt ctcaaagtgt
|
601aatgcaccca ggaatcacct ggggattctg attcagaagc tctgcattgg gtgctaaaat
|
661tttcagcttc caggtgatgc cagtgctact attctattat tgctgatgtt atctggaagc
|
721tggtttataa tgcaaaatct catgtcccac ccaatgccta ctgaatttca atcttccttt
|
781taacaggatc tccaggtaat ttttatgaac tttaaaattt gaataacatt gatgtagcag
|
841tagatcttgc ttattgctga tatgcagtcg aaaatattat aagttttgaa tcatcacaag
|
901aaaagtgtgt agaatataaa tgaatataat atgttttttc ctcttcaaaa tctgattttg
|
961aattatattt cccaggtgtc accggaagct aaagagtggc cttgcctcag gtcaggtttc
|
1021tactccctga cagcctctca attagctgct gttgtaatga aattatgcat tgtcaaaagc
|
1081ctttttgcat cattttcttc accaaatctc aagttttaag tattttatat agaaactaca
|
1141taaaatccaa ccctgctctg cccattccag tggctgccag atagctggtt ttctttgtga
|
1201ttttgggctg ttggttttct aggagaggag gagaagatta gagcaagtta aaacgccaca
|
1261gaccttgctg ctcttactga gattcagcca tttttcttaa gtaaacactc tccagattgc
|
1321atcaagccat tagttaattt acagaattcc aaaatagttg attctggaga tttttgctag
|
1381ttgcttatat ggtgaagagg atttttggag gtcttcacta caccattctg gctgatgtcg
|
1441cttaaaatgc cctgaagttt ttgaatggtg aacaaaagtc ttatggattt tcattatctt
|
1501gataYattag agaaaccatg catccacctg attgtattgg gctccattta cagatgccac
|
1561taaaatatct tgatagtttg aggcaattat tagatgagag gtcacagtga cctcctccta
|
1621agaaatattt ctcagaatta aatgtcaaat ttttaataaa cattgtatta tgattaagag
|
1681cccaggtttt taatgaaccc tgggatcaag ccctgggtct ggtccttaac gtgtaacctt
|
1741aatcaagtta cttaaccttt ataatacagt gataataaca gtatgtatgt atagatttat
|
1801ttcaaaattc aattaaatta caaaagcaaa gtgcttgaca cagttcatgg cacaaagtaa
|
1861atgctcaaga tgttttagct tctattgcta ttatcatagt taagaatatg gtttggtact
|
1921gataataata atgaatgttc tcttgaatgt gtttctttaa gagtcacatt gaaatagaaa
|
1981taaataaaaa ctgtctcact catgctactt tatgttctat gcaattctag gcactgtggt
|
2041ggtccagcag ttgatgtcag tgatgattag caaacatgat tgcctctttc ccaaagatgc
|
2101agaactacaa agcaagcccc aagatggagt gagcaacaac aatgaaattc agaagaaagc
|
2161caccatgggg cagttacaga acaaggagaa caataacacc aaggacagcc ctagtaggca
|
2221gtgctcctgg gacaagtctg agtcacccca gagaagcagc atgaacaatg gatcccccac
|
2281agctctatca ggcagcaaaa ccaacagccc aaagaacagt gttcacaagc tagatgtgtc
|
2341tagaagcccc cctctcatgg tcaaaaagaa cccagccttt aataagggta gtgggatagt
|
2401taccaatggg tccttcagca gcagtaatgc agaaggtctt gagaaaaccc aaaccacccc
|
2461caatgggagc ctacaggcca gaaggagctc ttcactgaag gtatctggta ccaaaatggg
|
2521cacgcacagt gtacagaatg gaacggtgcg catgggcatt ttgaacagcg acacactcgg
|
2581gaaccccaca aatgttcgaa acatgagctg gctgccaaat ggctatgtga ccctgaggga
|
2641taacaagcag aaagaacaag ctggagagtt aggccagcac aacagactgt ccacctatga
|
2701taatgtccat caacagttct ccatgatgaa ccttgatgac aagcagagca ttgacagtgc
|
2761tacctggtcc acttcctcct gtgaaatctc cctccctgag aactccaact cctgtcgctc
|
2821ttctaccacc acctgcccag agcaagactt ttttgggggg aactttgagg accctgtttt
|
2881ggatgggccc ccgcaggacg acctttccca ccccagggac tatgaaagca aaagtgacca
|
2941caggagtgtg ggaggtcgaa gtagtcgtgc caccagtagc agtgacaaca gtgagacatt
|
3001tgtgggcaac agcagcagca accacagtgc actgcacagt ttagtttcca gcctgaaaca
|
3061ggaaatgacc aaacagaaga tagagtatga gtccaggata aagaggtaag gaaaatctgg
|
3121aggtcgtaac taccagagag ggctcagtag cctcctactg tgggacagga tcacactgag
|
3181ggtgacatat gctggctcca aagtcaaaga aacacaagtt tgctccatca tttatgagct
|
3241ttgtgactgt gtgcaagtta gcttcatctc tgtgagcttt gattccctaa tgtaaacaat
|
3301ttaaatacta gtagtatcta cctcaaaagc acataagaag tgattgaaca tttccctggt
|
3361acagaatagg ctcaataatg tcatctttga ttattattaa atagatagat ttgcattaga
|
3421gggctggaag gagaggggct gtgaggagat ggacagagca ttaggagcct gttagttttc
|
3481actaacaaga aaaggatgaa actagggtaa aaaaagtaga agtaaataga cctccatgtt
|
3541ttattctttc aatcattgaa tgttgagaga gtgccttcta tctgccaggc tctgttccag
|
3601acgctgagga ttcagatgag ctgagagagg ccataagagc caggtgacat aggggattga
|
3661caggctgatt ttcagccttt gacttttact ctgagataga aatccatgga ggtttttgag
|
3721aagaggggtg acgtgaagta tgttcacatg aataaggaag actgtagcct aaatgaggaa
|
3781aaaagaatat gatttRtaaa gaagcaatta tgctaaaacc taattatatc aatgtgcatc
|
3841ttctcataaa atgatcaaag taggagtagc tcctctagtg ttctcagtcc cagtttcagg
|
3901ctgtgtgatt tggacaaccc ttcctccatg gtgtgctagg atcctcagtY ggttgttaag
|
3961ttggctttaa tttaccttaa tatgtttcct atccattcat caattatcag acaaaaagat
|
4021aacgtacttt cagaagctat ggcaaaataa atattaaaaa atactactta taaatgagat
|
4081tgaaaaatta cttccttgga aagtattttt ttggtaagtt tcactgagtg gaattgtggt
|
4141ttgaattttt ctatataatg gagagtgaca ggagatttaa agaaaaatat agggtcatta
|
4201tcttaaaagg ttactcttct ttctgaatgt agtttttgga accactatgt attggaattc
|
4261tgaattactg ccaatccatg atgataaatt agcatttcac actgggaagc ttatattttg
|
4321aggcaagggg tcacacttta aatgtagtag aaaaagaaaa aagttatcac tatgaatttg
|
4381cagatggata cattcatttc tgaggatgtt gctgatgcat atatgttctg agatctacgg
|
4441tatatttcag agattttgat aaactgatag aacttcccaa tagaggtcat cttaatgggc
|
4501catttcagtg tcacattctt accctcRtga caggccaagg gagagctctg cagtagggtg
|
4561gagggtgggg gaccgctcgt ggcctagcca tgaaattata gaaagttaac tgttctggct
|
4621aaattttgat catttctgtt tagagttatt catttttctt taaattcctt tataacttta
|
4681ccccacaagc attgaaggta gatggatgga tagataggta ggtaggtaaa taggtaggta
|
4741ggtaggtagg tagatgatag atagatagat agatgataga tagatagata gagagataga
|
4801taatagatag atgatagata tagatagata gatagataga tagatagata gatagataga
|
4861taatatttta ctttgtttaa ttatcaataa gatatatgtt taaatcattt ataactttac
|
4921cccacaagta ttgagggtgg atggatggat aggtaggtag gtaaataggt agggaggtag
|
4981gtagacagat agataatatt ttactttaat tatcagtcag tgagatatat ggtttttagt
|
5041tttgaaacat atattctttt tccctctcca aattggtttc taactttttc ttttcttatt
|
5101tttttttatg ttttattttt tgacagagtc tcactctgtt gcccacgctg gagagtgcag
|
5161tgatgcaatc ttggctcact gcaacctctg cctcccaagt tgaagcgatt ctcctgcctc
|
5221agcctcctga gtagcttgga ttacagatgc atgccatcat gactggataa tttttttttt
|
5281tcttgtggag acaggggttt taccatgttg gccaggcagc tcttgagctc ttgacctcaa
|
5341atgatccacc cacctcggcc tcccaaagtg ctggggttac aggcataagc catggcactc
|
5401agctagtttc taacaatttt cttaggaaat attgtattgt ggtcagagaa gttcatctgg
|
5461atgatattaa ttatttggtc tattaaaact attcccttat tactggattg ggattctata
|
5521tatgaccaag agatcaagtc tgttaatcag gctattcaaa gcttctgtat ttcttctcat
|
5581ttttatcagc tatatcaata atttttgaga aagatacttt aaaatttcct atcagtattc
|
5641tgagtttatc agtttctttt tataattttg tcatatttta tattgaacaa tttgaggctc
|
5701tactactagg tgaatagaag tttggagttg ttcatatctc cctgaagaat tgatcctttt
|
5761atcattaatt agtgcctatt tttcattgta ataatgcttt ttacctgaaa ctctattttt
|
5821tctgatatta atattgtcct accatcttcc tttgattagt aacttcctga tatgtctttt
|
5881cctttattta actttcaaac tttgtttgat gatttgatct aacaacttac atctttacaa
|
5941ttctggaata tttttttcat catctttttg tctatttcat cttcccacct tctcaatttt
|
6001ctctttccag aacccttatt aagctatgtt tgaccttgtt aatctatcct ctgtctttgt
|
6061taacttcttt tttccatatt aaatttctat aattatcatt tttgaggcat tctaggtaac
|
6121ttttctcaga cctgttttgt agcttactaa tactctgatg agctaattca attctgatac
|
6181ttccccaggc ccatgattgg agattttgta gtctcttctt cataaaaaca gttaatgttc
|
6241caagctctca gttaaattac ttgtagtttt ctgcctgcct aatactggag gcctcacctt
|
6301ctgtccccat gtgaaaaaga aaaacctaga cccaagctct gtggcctcta tccaagacta
|
6361atatccttcg tgtgcttcta cttattgttc tatatttcgg tttcttcctt ggttctgatg
|
6421gctgaagctg ctgttttatt ttaaccttga tgatgtattt taaaaatata tttcttaaaa
|
6481cttttccagc acttttatat gtttgcattg ggagggattt cttctgtatt caacttagtc
|
6541cttttcattc ctggaagttt cccacaagca cctgatacat acaaatgtgt caatatattg
|
6601ttttgtaagg gttgtccttc tcagtatttt aatttcaatt tcttccaaaa ttttggctct
|
6661aaaatagctt tggaaaacaa agagaatata ttgtagaata attctgagtg gaaaccagca
|
6721tagtaccaac ttttcatgta aaaatgtggt catatgttta aaatagcctt ctaaatgatg
|
6781taggattaca aaatatgaag tattattttt taaaattcta gttgcttaca aagagaagga
|
6841agattaattt ttaagtgttc ttattatctg gatgaaatat caacatgtgg ggatcaaatt
|
6901tttcaaagca gaaacataat tgagatttta atttaaaaac tgttattaaa ataatcagat
|
6961atctgagagc tacacatgca ttaacctttc aaatttcagt ggtatggtaa gtttgaatga
|
7021gtcccatggg acttttgctc agaataggag aaattaaaaa gtcagccgag gccaagatac
|
7081atcttaaata aagatgtaac tttaataccc ctcttttgaa taatatatgt atatgatttg
|
7141gatcttagtg gttatggaga aaacagtctc tgtttttaaa aacgttactg cgaattctac
|
7201aattatccaa aagctataca aaacaactat caatttatag agatataaaa tacctatgcc
|
7261cagagctata ttaataactt gggaagcagt gagaattggg gatggaaagg aatgggcttt
|
7321atttttacaa aatatgagat gcagtgctta tttaacacat gtgatcttta cctctcgtat
|
7381caatgtaagc tcattacttt gggtactctt ttataagatg ggactctata tgctgccaaa
|
7441aaccccattc ttagcagtga acttaaccaa caatgacatt ttcctatcac tatttttcct
|
7501tttatagaag gcaaatgtta ttgccctctt tttttttttt ttttgttaac tatcagactt
|
7561tcctgctgca tttagtgtag tgaacttYac aatttaatgt ccaggaagct ttctgcctcg
|
7621tctgcccggc atgtgttact ggcttatctg tgctggcatt cacttattta ctattaaatg
|
7681acagctgctt ccaagagagg ccttgggacc taatgactaa ggtgacagta aatcatctta
|
7741gcaaacagta aaataataca acaaaattac atcctttaaa tcattgaaag ggctttattc
|
7801caatttccta agcatcataa agagtttaga aaatatttgt atgtctcttg catttcaagt
|
7861gaataaaatc actttatctc ttactcttgc gtccccaccc cccacccccc ccaacatcct
|
7921ttgtagctta gaacagcgaa acttgacttt ggaaacagaa atgatgagcc tccatgatga
|
7981actggatcag gagaggaaaa agttcacaat gatagaaata aaaatgcgaa atgccgagcg
|
8041agcaaaagaa gatgccgaga aaagaaatga catgctacag aaagaaatgg agcagttttt
|
8101ttccacgttt ggagaactga cagtggaacc caggagaacc gagagaggaa acacaatatg
|
8161gattcagtga gcctgctttc gcctgctgtc tctgatggct ctggcaagga ctccagggat
|
8221tctggtggga tatgacttag aaccaggtgg ctggtcacct ggatgtacag aagtctaact
|
8281ggtgaaggaa tatcatttac agacattaaa catccatatc tgcaatgtgt accaaagtta
|
8341tatcatgccc cataatgcta ctgtcaagtg ttacaactgg atatgtgtat atagagtagt
|
8401ttttcaaaag taaactaaaa atgagaagca tatttcaaga attattttat tgcaagtctt
|
8461gtatttaaat gttaaatcaa tWtgttgttg caatttagct tgctttcaag cttcacccct
|
8521tgcacttaac ataagctatt tttggcattg tgttatcatc ggcttatttt atagatcaat
|
8581atttttattt cccttttttg ctgaggaaat gaagataagc aaaaatataa atatatatat
|
8641aaatatatga gttattaaaa tcagaagaat actttgtggc tgtgctgttt gtgccaatag
|
8701actttgtcat gaccaaaaag agaaatgtaa atagttttat aaaatacagt cgaatcacca
|
8761ggaacctttg agctgctttt aaaattcttc ccctggcacc actcagtttt gcttttgcga
|
8821ggcgatttga cataggaact ttgagactcc atgagaaagt ccctttctga ggcccactgt
|
8881ctaccttgcc agatcctcag tgcgtatcgc caatgcagga tgctccttag aaaagaaaaa
|
8941atggtaaaga atggcattta acgattcagg ctttgaatta ctctgtccct ctggaccgaa
|
9001tctctttaac tgctgSaYag ttttagagga attctcctgc tacttaggta ctgggaaaca
|
9061atgcttgcta aaccatgccc acgtgagcac ctgtctccca ctcaaacctc tcccatctcc
|
9121caacaactgc actttagaat accagcagtg aaatggtatt actgtttccc tctgagtgaa
|
9181actgctagag tatatgtcac gtagtgacat ttttttctca ctcaggctat tgccatctgg
|
9241gattctctcc ctactacagc tggcaaagtt ggtttgcagc aagaagatag tgggaggggg
|
9301ccaggctgca ggagaaggag aaaagtttag aagaaacaaa ccattttgct tctaattttg
|
9361acagtatcac tttcctgtta aaacatacaa taattttaaa aggtgaatgc ctaaagttcc
|
9421aattttagca aatatgggaa cctcagcaat gctaattttc tagaaaaacc cagggctctt
|
9481tggagctaga gttttgggag aacagttctt cacaataagg caatggtttt gagaggccag
|
9541gcaaataatc tttctcaccg tagaacaaaa agttacaaaa ggcataatcg gaaatagaga
|
9601ctacatactt gagtttatgg ggtttgtgtt gtttgaaggt tcaatgcttg catgtgttta
|
9661tttattttca agagggaaag tggtctgtac tgctttcatc cttgccactg tcttgctttt
|
9721attttttact ctcccactga gcaagcRtct gtggtcctat ggtatcaacc agtatcttta
|
9781tagcaataat ttctttaatt cccttttctc tctctttcca attatttaac cagttacttc
|
9841cacctggaca tacgatagga aattcaaact caaaatatga aaattgatct taataactct
|
9901cccttcatat cttttcacct atttccagtc cttatcatag ttgataaaaa cctcagactc
|
9961atccagaaag ctatatgatg cactagtaaa aaaaacaaag atattcaaac tgcttgggtt
|
10021caaatggtat acaatttgcc agctgttact gaaccttcta tgcataactt tttttttcct
|
10081ctgtgcaatt ggaataataa aaatactact cccatagagt tgttatgtgg tcttaatgag
|
10141atagcttggg ttaggctgag cacagctgct agtagaatcc aaaaaggggc caggcatggt
|
10201cgctcacgcc tgtaatccca gcactttggg aggccgaggc gggcggatca cgaggtcagg
|
10261agactcagac catcctggct aacacagtga aaccctgtct ctactaaaaa aaaatatata
|
10321tatatatata tacaaaaaat tagccgggtg tggtggtggg cgcctgtagt cccagctact
|
10381cgggaggctg aggcaggaga atggcgtgaa cccgggaggc agagtttgca gtgagccaag
|
10441atcaagccac tgcactccag cagcctgggc gacagagcga gactccgtct aaaaaaaaaa
|
10501aaaaaaaaaa aaaaagactc cataaatgtt aacgcatatt ttctttcttt ctttctttct
|
10561ttttttttgt ggggggacag tctcactgtc tccttctgtc acccagtctg gagtgcagtg
|
10621gcatgatcac ggttcactgc agccttgacc tccctaggtt caggtgatcc tcccacctca
|
10681gcctcccgag tagctgggac tgcaggcata cgccaccatg cccagctaat ttttgtattt
|
10741tcttttgtag agacagggtt tcgccatatt gcccaggctg gtctcaaaca cctgggctga
|
10801agctgtctgc cctcctcagc ctcccaaaag ttatgcaaga tgcatagcaa tgacgggtca
|
10861cttaatttgt ctgggactac aagcgtgagc caccgcgccc agccaactca tatttttctt
|
10921ctctacccac ttcttcactc ataaatttgc tcaccagcta atctattcca ctcatctttg
|
10981cctttttaat ctgctctctt taatcacttt tcccttacct tttgatgaag gcatcctacc
|
11041cagcgcgttt tgttccagca tctctcctgt acttttgtcc tttgcaggct gccttttcga
|
11101aattattcat ctgaccatag cttgatcttg ctcattacat atgatgactg tcacttgccc
|
11161aggacaaagc ccttcacata gtgtaaaagg tcctactgcc agtttcattc ttgtctccta
|
11221ccacttccca ccacacctgc catgccattt catacctcta gaactttcca cttgctattg
|
11281ttgtgtcctt cttgcttgcc ttctttctag ctggcatgct ccaaacatcc tttaagagcc
|
11341aaatcaatgt cagtttcctc atgaagcttc ccagaatctc aaatcagtgt tagttgcttt
|
11401ttgtgccccc attcgcatta tctctttctg tctttcccac atctgattat tttctttatc
|
11461aaataagaag caatttagga gggagagtga tgaagtggaa atagcagaaa attgagagcc
|
11521attcaaacct agatctgcct ctcaacatgc cttatgcaag atacatggca atgccaggta
|
11581acttgacttg tctgatctca tctacaaggt ggagataata actcctacaa agtagggatg
|
11641ttgccgtggt taatggtggt atgtaatgtg cttatcccgg tgcctgtcac tttgctccac
|
11701tgataactct attgataaat ggagcttctt aaggggccaa gattgtatct tcttgctgtt
|
11761aaatccctcc atgccttatg ccaaagagaa tgtcagcaca gtgagtttgc agtaattttt
|
11821gggaatgcaa atatactcaa acacacacac acacacaggg tgttttgtgg cctgtgatat
|
11881ttgagggatg atattatcaa ttttaattgt caatttcagt gatgatggca ctaatcaatg
|
11941gataccatga gcagcatgtt catctgggtt tccgttagtc aaataaaaag cctagacaat
|
12001attaagtaca attaacataa gaataaattg gaaatcaata aggatacaaa gtagttaggt
|
12061agtatcaaga tttcatttgc tacatcctgt atatgcctct ttaaaactat ttaggtaatt
|
12121aaaatgaatc ttaagttata aactcgagaa aggatttgct ttcagatgtg gggcctactg
|
12181tgttagcctc actattcaaa ctagatRtct gggtatcctt tggagaacat ttaaggtaga
|
12241attgcctatg atgtcagctc tactgaaaca tgattttatt atatgtaaca ttatgaaatg
|
12301actaaaatct ccaggtggag tttaagtaat cattcccatt gattctcaag ctgggatatt
|
12361cttcaaaaaa tcattcccag gctgggtagt ttatattatt gatataatta tgacaccttg
|
12421aaaattcagg agagcattaa ataatgtaat gcttgccgca aaccccagtg ttccttacac
|
12481tgcagagctg cactctgatt agagtaccat acgcatgagt tttggaatct acgaccaggg
|
12541ttcaaaccca gctctgccac ctcatagctt tatgaaccta aattatgtaa tatatataag
|
12601cctaaatttg tttttttctg gaagtagagt taatagttcc tcccttatca tatttttatg
|
12661aggaatgtag tacaataggt gaagggatta acatagtgcc tggaacatag taagtgctca
|
12721ctaaatggaa actatcagcc ctcaaattat ttctgttgaa agagtgtttc agcttctaag
|
12781gaacgtagca aggttctgga ctcagggata tgaccagcat taaaagtatc atgatcacca
|
12841gcacaggata taattatatc ttggtctcag agactcttaa gtttatccgt gcccagataa
|
12901tctgccaggg attgatggca aggaaagtaa cccaaaccac tctttctttc tgagataata
|
12961caattacatc catgatctga aaatcatgtc taaacaacta cgtgtaactg tccttcatca
|
13021actctatcca tgtctacacY aaagatgatg ttgggtgtta aaggtattgg ataaaataca
|
13081atgaatgttt ctgagggcta tcatgaataa actgagggct gtggactagg tcctctgggg
|
13141tacataaact tacagttatt gccatgttat atgatgtgct gtggaagtaa ctaaagagac
|
13201cataaaggtg aagctcagga gagcactgca gagccgtgac tttggtgtga gtcctaaaga
|
13261ccagtaggaa gtcatcagac agagctgcag ttttggtaag gggccttcct agcccatgga
|
13321acagcatggc aaatgtgcct tcagggtaga ccctagggag tcttttcaat aaaataaaca
|
13381tgacctacca agttcatgcc atcaagatgg cattgtgcct aacaccttag cagcacgtca
|
13441tgagacctga aaacacactt agtacccacg cggcttctac tctcttattc aRagaaagca
|
13501tccagagctg gaaacatttt gccttgtttg aactcacaaa ctacaggaaa ggagtgctgg
|
13561aactgtggct cccaaaggtc tgtttcatta ttctctttat agtcttctta actgcacaag
|
13621tggggaatga gttgaaagtt agaactgccc agcttaaggg cctcttgctc tgaagtgact
|
13681tggagaacta acagttcccc aggcagctaa aatctactga acctactgta gatctttcag
|
13741taaaaagttt agctgatgaa aagtgtggtt tttaaagcac catttgtggc tcaggtccag
|
13801gKttgaatga tactccttat ttatgaactt ctgtatagct gctgtctgta tggcctcttg
|
13861aaggataagc cacagtgagg ccagcctttt cttaaatagg gaatgagggc aacaggaSaa
|
13921cagtgaattg ttagggggca aaccaaattg gcatcatttt ctttgagcaa aactgtctct
|
13981tacttctggg ggaggccccg agcatcccac ctgttcttgc gaatagagga tgtccatccc
|
14041aactctctct tctccacaca cccattccct gttccctacc ccctcatgat tcactagatt
|
14101aattatgcac cacactgaag tgatccccag ggtcatgcca tcagaccctc atYgctggtt
|
14161acctgttgcc aaaatagtcc aagttcccat gccatttttc cttcatctat ttgcttatcc
|
14221ccatattgcc cagtgtattc tctcatttgc ttctatctcc aatggcctcc ccctgcctag
|
14281gacttttcca ttatcccctc tagatcttac aatgccatca ccctccccta tgtcctcttc
|
14341tctgaatcat ggttgcctcc tgaagacacM atcttccctg cagccctctc aagcctagct
|
14401atcttcctct ctacaacctg cgtatcattg gcctgaaggg gagacatctt gctttgctat
|
14461ttgcagctac tttcagacct ttaatccttc ttcctctcta atgaccttct tacaagcaca
|
14521tgtctcctta tcattgactg aatattctag cacctaaccc actcaccctc cccactcata
|
14581ctccattcac catcttggcc actcagctcc ttgacgactt ttgaaaatct tgttctgccg
|
14641ctgcctgaac atcagccacc acactcatgg ttacactgcg tactgtgtca tgactaatca
|
14701ctggcatcgc caacagttcc atttcaagca tcccacgctg tggtcatcac ttcttctctc
|
14761tctagtcact ccccttagca ccatcactcc aaattggtaa gttttcagcg actatcatcc
|
14821cccatttcat tacttccctc cttgaccagc ttagcttcta tggttccttc tcataattat
|
14881tctcttgccc ccatttccaa atcccattat gtactctccc agcactgtac tactcttttg
|
14941agaattaaaa agaaacaaat tgcaactcta gtaatttttt cttactctta acctgtgcct
|
15001aaaaaaacta aacatgactg gagaacaaaa gaccaccaag ttgacctgtg ttcctttgta
|
15061tttatatKaa tatggctcac atggttttca tcactgtcca gtaacttatt gtcacagttt
|
15121ccaaggtcaa tttcacactt ctcaaacttc cacaaactct tcattgtcta ctgacaacct
|
15181tacttctatc tttactgaga caacaaaaaa aaaaatcaga tgagtatgta cttatgccca
|
15241tcacgtcacc gtattcccaa actacctgcc tctgtgcaca ccacctcact gcctgctgca
|
15301gttactgtcc agggccagcg cctctgccca tgtactggag cctgtccctc cacccttttc
|
15361aagcatgtta ctctatcaaa taaatatccc tttctctttt gcattatcag ttttgctatc
|
15421tctctgttgg ccccaccagc actattaccc atgctatatt agcttttaaa aaaWtctctc
|
15481aatctcacat ttatctccaa cgtttacatc attcttttgc tgcactttgt agaaaaatat
|
15541tttgaatttt ctgtatctat ttctacttcc ttacttccca tgttttcttg aactcactcg
|
15601agttactctt ttcttgctca atactggata gaaactgctc tcattggggt catcgatgac
|
15661cttcaaacag atttagtcca actgtgaatc ttcagttccc attttactca gcctctcaat
|
15721aacaatccgc ccctgcccat tctctcactt ttgaaacacc ttctttactt ggcttccagg
|
15781acagcacact cctggttttc cctctacctc actgaacatt ctggaatacc ctcctgtttt
|
15841ctgaggtctg tatgttggag tgagaggcat ctccatcttt ggttttctct tctttaacta
|
15901cactgtcttt tggtgggctc atacaggctc ttggctttta atactactta taaactgatt
|
15961actctcagat ttctgtttca gctcaccctc ttccttgaac tccagcttat aagacactcc
|
16021tgctactcca cgtggatttt tttttttttt cttttttttt ttgagataga gtctcactct
|
16081gtcacccagg ctggagtgca gtggcttgat atcggctcac tgcaaccccc gcctctcggg
|
16141ttcaaacaat tctcctgcct cagcctgagt agctgggact acaggcacat gccaccacac
|
16201ccagataatt ttttgtattt ttagtaaaga tggggtttcc ccatgttagc caggatagtc
|
16261tcgatctcct gacctcatga tctgcctgcc ttggcctccc aaagttctgg gattacaggc
|
16321gtgagccacc gtgcccggcc tccacttgga tatctaataa acatctccaa ctgatattcc
|
16381aaaaacaaac atgattttct ccccaatgtt tttctaaccc attgttcatc atctcagtca
|
16441actgtaccat catttacttc atggtttagg taaaagaatc tagagccatt tctgatctct
|
16501tgcttttata tcacaatatc aatctatcag caaatcttct cagctctgcc ttcacaatag
|
16561gtccagaatt caaatccttc tcaccatctc cttttcctag tctaagcccc atcatgtctt
|
16621tctggattaa tgttttatcc tacgatggat ttttttgtcc ccattcttat ctttcttcct
|
16681aagagtcctc tttactcagt agccaaagga atccttttaa aaagaaaatt tagcttatat
|
16741catttccttt ttcaaatcta accaccatct tcccatattt agaatcaaat ctcaagatct
|
16801tgccatgctc tgacccctgc ttctctctcc aatttcattt acaatcccat ttactcttgt
|
16861tcattctgct ttatccacaa gactctttgc ccctccttgt ctatataaac aagctctccc
|
16921tccaaagcct gcccctgctt tctcttcaga gtctgaaatg cccttctccg tgtcaatagc
|
16981tcactctcac ttcagtcagg tctctgagca cttatcccct cttctgagag gcttgccctg
|
17041accaccttgt ctaaaatagc atccctttcc caccttactt tttaacctgc tttgtggtct
|
17101tcgtacttac ctctatStga cttctccact agaatgcaga ccatgtgaag gcagatttgc
|
17161tgacttcatc acatcaacta tgtgtaccta gaacagtcct tggatggttg acgtgcttga
|
17221taaataaata tttgttgcat gaatgaatga gtgaatattt agagctctat gtcaaatttc
|
17281tggttcagat gttcagggat gttctcagtt ggacctttta ataaaaaaaa acaataaatg
|
17341accaaattct actttaagtt attttagggt tccaacagtc acccatagac tgaacaaact
|
17401ccgaagattt ggcttcatgt aagaatgtca ctgcaaagaa gcttcagtac ccattgtgat
|
17461atcatttgct aatttggaga ttgtgatgcc aaaagtataa gccccatgct cagtcagcat
|
17521ctaggtccaa tagctctcag aggaaccata catcaaagca aactttctgc aatgcggaaa
|
17581agaacatcca tgcattttta aaatgaattt taaattttaa ataattttta aaagtggttt
|
17641catctcttgt aatggaaaat attcaaaatt ctcatgctga ttcatgaagt atacttatat
|
17701aattagacaa aataagaaca ttgaaagaag cagactcctt gtttcatcgc tttaagcaaa
|
17761taataaaaat ggactcRtgc aagtcacacc actaatttaa atacattttg taaaaagata
|
17821gcaaataaat gaaataaaaa tatttgcttt agttttttta aacaaagatt tattaactct
|
17881gaatttttta ggttaaggac catgcaatat atatctccta caccgaagtg tccaagaaat
|
17941gtttttggag taaattaatg aactgcttta gaatgttgct cagaaattaa gctagaaatt
|
18001cagagcaata ttctcagggc ttgatttaca ccaaatccaa gttcgcaatg tattaacatg
|
18061aaggaatagg ccattgcttt ctgaaaacct tccttttata aaagaaatac tttaatatta
|
18121tgaattctct tggtctgtgt aaaatattat ttgcattata aaaattgatt ttttggtata
|
18181attgttcata ggcaatattt tcaccaggat gggttcacaa gtgttaatgg aaggcgaatt
|
18241atgtgtggga cagtcttcta gggaatatgt gaggggtttt taagatggat aacattttgt
|
18301acctgctttt gagttgcaaa tgatctggac tgttggttaa acatcgcaga caagatcagg
|
18361tgaagaacat tactagaagt tcagtgatta agaaataaag ccacgtaccc cacggagtga
|
18421aatttgaatt ccttaaattc cctcaaatta ttttatgttg gattttacac caggatagga
|
18481atgtctttaa aagtaagaaa tatttgacat aaggtagaaa atttcaaagg agtgtttgac
|
18541ttgttgctgg atgtgtcacc acatttcatg tgtctgagaa atataaattt ctacagcaca
|
18601tttttagtgc cttaaacaga ctacaatgat gtaaatggtt gaacagttga aatttagtct
|
18661ggaactggga cagatgactt gccacataga gtggctccca acataaagtg atctgtgatg
|
18721gcaggacttt cagcgtgttt cactattagc atgtgtcatc caagcatgcc tttcaacatc
|
18781tgtggagaaa agacatgtta caaatacaaa acaccaccat gatgaattgg gaatgtcaaa
|
18841aacctctgcc ttggctgtga tccagtgttg ttattggcaa gtagattcat ccttctaggt
|
18901tggttgctcc ataagtaatc ttcaagaaaa gcaagtccaa cacccttttt tctccttact
|
18961gtgaacttgg tcaaaattac caaatgtttg gtaaccattt atggtatcag gaatgcacca
|
19021ataactcctt ctgactcttt aagagcaatc atcttgtgga atgcaatttc ccttcttatt
|
19081attgtgggta tttttaggta cctatgcttg acctttttta aagagagtaa ggatctgtga
|
19141tttaaactag gatagaagct gttccagaga taacaaaaag ctgttgcttt ctatattcca
|
19201acaggaacta ggtaaaacga taaatgtgat aactcaaaat aatgtgtatg tttatcttcc
|
19261aggctttcta atagttaatt ggttaaataa aacattattt acagaaatag aagagccact
|
19321cctcaactgt tcaaacactg caaagtaaac taatgcaagt gcagtgacct cttcatccag
|
19381ccacaaaatc atatatattt ttaattctcc aaggagtttg agatagtaaa gttggatatc
|
19441atgtagctaa acaaaggctt ttaccttttc tcttggaaaa tagttaaaat gaatagRaat
|
19501ctgataatta atctgggaaa tttaaccctg ctctacttac ctaatgcccc cccaaaagat
|
19561gatctttttt ttcttcattg attttatacc ttaaaaagaa attactgaat tgcagatata
|
19621caactagtat ctacagacag aaatgMaggt cagttttaga agaaaccagt gtcaaatgaa
|
19681aacacagatt tctacatggt cacattcata tcacacactc ttgacccaag gtgagaaagt
|
19741aggtcattcc ttatttctta tttattccct ggcacaatca gaccacacta caagtttctt
|
19801ttaccagttg ccaaaatgaa atcatgacac ccttcagagc tactgtcgtt acatgcaact
|
19861caagacaacg agcagcatca taaccattgt caacaggcaa actccaacaa tgtctgggtt
|
19921tggatttggt tttatgttga gagaagcaga tttcctctga ttttaataat ccataagaaa
|
19981cagaaatcat aatatattga ctccatatta cctaaaaaga gtcaaaagaa gcagaagttc
|
20041tcccccgatt catcctcttg ttccacagac attttgaaaa taaaagaaga caaaatagaa
|
20101aggaaagggt gtgagaaaga acacagaaat gacttgaacg atttcaaatc cttattaagc
|
20161atcactgagg ttgcatttta cccattagac tgactgaatt tagttctcac tgctcagacc
|
20221ttgcaaagaa actggacgta catggttttg ccttccaggg ttgatctaga actgtaaggg
|
20281tgcatgtgaa tgtgggtatg catgtgtgtg tgctttaagt ccattttata aacactgaca
|
20341caagacaatt ctcatcattg gtaatagtct ttggagtcca atcatgcaga aaaacaggca
|
20401ggtgcaagtt aggtctcatt gcaagatgga catggcaagg tgaacagata atcctacata
|
20461aggattggga gatttgtgtc cattagaata tactggccat tggtcccaca taagtaaagt
|
20521tacatataca agattctata tataaacaga ggcccctcac ttcagtttgg ctgaccaaag
|
20581aaacaggtca aagtgagcca ttttcagata gttaaaggac taagtaccaa aagaaataac
|
20641aaaatcttat cctctaatca caaagaaaat agctaaaata actatttaca ttgcaacttt
|
20701tttgttgttt ttacagagag gagtttcctt gcttggctta atgatatctg tggaaaatgt
|
20761tgaactctta taattaaaat gtgtgtgggg gattgtgagt ggggagttgg gttcctcttt
|
20821ggatgcaaag tggctgagat caaaaatttc tagagcaatt ttactcctct ttctgagctg
|
20881tagaagaata catttttcag caaagctggc taataacatg ccttacagag cataatgcac
|
20941ttaagatgtg gcttttcata tgttaagaga ttcaaatcga aatagatttt gtataattta
|
21001ggttttgcaa tgaatattta caattttaaa acaaatcaag tttgcttatt tttttttcct
|
21061tgacaggaca taaaaggttt tacatatttt tatctatttt ttactagttc catttactaa
|
21121ggccaacttt cagttttacc agtcagctgc tatcagtgtc tttagataat atttttctga
|
21181taacagattg aaaaaactat cgagcttctt aaccctcaat taaatagctt actccaattg
|
21241gtgggaactg gccaggctct ggtccaactg ttgggtacat tcctacaaaa ctcagtcatc
|
21301agattcttga agatgaaagg ttattatcag tttttattcc acaagaagaa attccgttgt
|
21361aaggctagtg tattcctatt taaaattgaa cacgctgacc cacaaaacac atataaaaat
|
21421agtaaagaca tattaatagt aaagtggtgg cggttttgcc aaactcttgc agcagtttaa
|
21481ttttccctgc acatgagtac acagccatcc ttcctacaaa atactgcaaa ctattttatt
|
21541aaggatcact gcaaaccaac tgccccaaag gaagcctaac agaaggttag gctcctcaga
|
21601gtgccaactt catgttccaa aatgagcccc aaccccaggt agaaccttca ctttttttca
|
21661ggaatattgt ccaggtgact tgacacttgc ctaccggaaa agttgggatg ttcttgggaa
|
21721ataacaggtg actatttaag aaatatttgg Kgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
|
21781tgtgtgtgtg tgttaagaca gacaagtgaa tgcagaacat attatattct gtgaatttga
|
21841taatatcatc acctcctaga catattatag gaaagcagac ctagtgggca aaggactggg
|
21901gggcttttac agtggtgatt ctctttgttg ttccatcatc tgccttgctt taatcaccta
|
21961ataaaactga tcctgcaaaa attctggggg ccaaatcctt acctctattt gtaaatgata
|
22021cttatattca aggaatttgt tccatttttc tcttgtccat aagggaaatc tggctaaagc
|
22081taaccagctc ccaagagcca tgcacagaag atgtaagact aattgagctt tgggaaggta
|
22141ctaacagcgg gggaggggcc ctgtctagtt cttgcctggt ttacYctgag ggggaaattc
|
22201accacttatg caggtacgag agatagcctg tcaagcactt tgaagatgct ggctggagac
|
22261ttccttctgt cttgtgatgt catcttgcgg ctgatgaaat tccccttgag actctcttta
|
22321aagcagcttc ctgctctccg cacttaatcc catgtggtat aaagtaaggg aggggagaag
|
22381ccacagatat atcaagagaa aagtaccgag aaagaaaatc agtaaagaat tagagataca
|
22441gagaggagaa gtttttaaaa aaaaaaaaaa aaaacaggaa tatgaaagag agggagctca
|
22501agtgactgag gaggcatttt taacaatcag gttatctgca atattaacca gaaaaaaaat
|
22561ggtagcaaaa tagagaaaat gggccatttt tattccaggg gacaagctgc acaaaggaat
|
22621gttcttctat ttattttaaa caaatgactg cgtgtactga atctgactgt gtgaaataat
|
22681ctcagaatgg cagcaccact ggYatggcga tggtgcaggt gggtgcagtt ccctgtggtc
|
22741tctattgctt gaagagagaa agRaagttcc ctattattat atttaaggca gttttcagag
|
22801cactggcatt cttgtttgct ctgttttggg gatattctat ttgccaatca gttcacactc
|
22861atcaaccatc cacttcctgt ctttcacttc ttcaggtgaa atatcaccac tctagtgagc
|
22921accaacatgg tcagagtgca aataactgtg atggatactt cgaagtgaat aagaagggaa
|
22981gcctgattat tgctgagatc accttggtat tgccttgtac ataaccaaga tgtttcacag
|
23041tgcctcctta agtgctcagg aaagcacttt catttaattt aatttaagct aaattctgga
|
23101gattttgcta aacattgaca ttaatgcttc atggctttta agacaaactc atattgctaa
|
23161aactatttgg cagcagtaaa tttatgggca gagttattgc tcttacatct actgcagtac
|
23221aaaactcaga tgatcagccc ttcgattgct catacttatt aaaataaata aataaacatg
|
23281aaacatcagc cacattaagg agtcagggaa actcctgagg aataacaatg tctctggaga
|
23341tgttttcaaa tgctaacctg agactcacac tgtggtttgg gggtttcatt Mttattatta
|
23401ttattttatt tcagaagagg aaagtaatat tatttctcaa aataaaactt tggcagagta
|
23461tgaatcaggg aagcagccca cacatggaaa acacaatcca caatctgaaa gtagtctagg
|
23521caggctcatt tttttgttga aggaattcac atggaggcaa ttctgctcag ttccagagag
|
23581agattcttat catcaaaagc acacacaata accttgcttc accacctgcc actttctcca
|
23641gtggcctctt gttgtgacca gtaattgaga aatgacaaat gggtatagag ccaaatctct
|
23701aaaacaggga caccagtgtc tcctagtatc tgggtaataa cctcctttca gtcttagtcc
|
23761acaccacaca ctaccctcca gtctctccta ctctttactg tcacagaaaa gactctcagc
|
23821ttttattcac acctgccttc Wgaaggccaa accattttgt gcctgaaaac tgttacccac
|
23881tcSccccaca ctttacataa gtatcacata tgttctttct acaaattggt atacaggtgc
|
23941catttaatcc attcaaattt ggaagctaca tcttcaaggg tctgagagag ctcactcccc
|
24001ccatatattc cccctttaca tgttttctta taagacatac agtttaatca attaacaaac
|
24061taaacagctt atatactggc aatatattac agatgggttt atgtcagagt aatagatcac
|
24121atgaaatgga cYatgtggta ccccagtgca ttatgtcttg gtagagccYt gaggacactg
|
24181acagtagcat ctctaagtaa gtagtgctgt atgaatacag acacatgcgg atctgtatct
|
24241acatccatct gactaggcca aggagcaggt agatgcaaga tagagacaca cacatgctgg
|
24301atggggccac tgcacacctt gtcatgccat ttaaaagggc agttacaggt tgccggtttt
|
24361gcagccatta aaattacact ttatggaaaa ggcttctcta attgtgtctg atttgctttc
|
24421tgtagtaagc atcattggaa gaagaccaaa gcaagagcaa ctagaagtta aatatacatt
|
24481tgagcttagc tgcaatacag aaccctgggg aagaagcagg ctgaaagatt tatttaattt
|
24541taggcttgga ttctctccct tgctgttttc ttgatgttgt gtgtctgcat ttgtgtgtgt
|
24601gtgtgtgtct gcgtgtgtgt gtgttccatc acatcatctc ctgaagaacg ctgggtttcg
|
24661caggcaggcg gctagtcacc tgcaacaacc caggggtcct gccgaggctt ccaggctgct
|
24721gtcagtgtca gatgccaggg tctggtcggt ggacatggag gagatgtcat tgacagacga
|
24781ggatggaggg agactctcac tgctgttcac tgctgcacct gtgctaagaa aatgaagacc
|
24841aacatgactc aatctagaac cagacccatc ttaatgccat tcaggattca gggatgggca
|
24901aatacaatag gggatgtcca gtccatcaat catttggcaa gcctttatag agcagctgac
|
24961ataggggagc atatcaaatg gtgacaatca agacatagca ataaaaagtc cttcatcaca
|
25021agttatcaaa tctcactcta tatttgaaat cacctgcaac actttctatt aaaaaacact
|
25081aatatctggt cacattgcct cccctgcccc cactgcactg catatatttt aatataattg
|
25141gccttgggtg aggccaaggt atttgcattt ttatttattt attttttttg agatggagtc
|
25201tcgctctgtc gccaggctgg agtgcagcgg cacaatctcg gctcactgca acctctgcct
|
25261cccaggttca agctattctc ctgcctcagc ctcccgagta gctgggagta caggtgcgca
|
25321ccaccacacc cagctaattt ttgtactttt agtagagatg aggtttcaac atgttggcca
|
25381gaatggtctc gatctcttga cctcatgatc cgcccacctc tgcctcccaa agtgctggga
|
25441ttacaggcgt gagccaccac gccccgcggg catttgcatt ttttaaaagc tcctcagaga
|
25501ctgtattcag ccaagcattg aaagcctctg gcttatgcag gagacaaata agcaaaaccc
|
25561cttaatggag ccatctgagc ctggttgttt ttaatgcagg gagcttttaa aacaaacata
|
25621tgcaagggtc ctatcccaga aatagaagct gaagtgaagt tcagaaatct gaattacttg
|
25681gggaccacat ctctagagaa aggaagatat ataaatacta ttatgtcatc attaatgaca
|
25741ccaaacttaa aatgcatata gaaaagccag taggacataa gtaggactgt tgatgaaagt
|
25801tacaaaaaaa aaaaaaatag gagaagcctt agcacagctt ttgcttatga gctaactctc
|
25861cagcaggctt gcttacctgg gatctccaaa taagaactcc aaattattaa cttagattaa
|
25921cttgaaaaaa ttgtttatct gttatgcggg agtataaggt tgaaaccctg agaagaaacc
|
25981tgcccaYggt aatcactcag taaaggctag ctgagttgcc agtagctttg agatcaacaa
|
26041aagaaagatg aaccaaaggc attgtgcgat aYaattaaac cagagcaccc tggaaacaat
|
26101ccatttactt tttttctttg tatattcttt atacctaagc aatctgagtg gtaacacact
|
26161tgctttgtga aatagctcgc tattaaaaat ctgtagtata gtcccctaat caaataagag
|
26221atgaggaatt ctcactaaaa ttatatctta tttgagcaaa tatagtgtgc aagatctatt
|
26281tggtgaaaaa taataactcc aaagtcagtt ataatagtgt tatcacatag acctaataaa
|
26341tcagaaagac aaaataaaac taaattaagg aagggRagtg gttaacataa tccttgctcc
|
26401tggagtagac atttcttgcc tgtgagaaaa gtgtgatgaa aatgtatcag ttatctagag
|
26461aggacacaaa cacctaaact aagacagatc acctgtatct tccatgtatt tttaagttgt
|
26521atttgttgac tataaatata tggacgtact ctatgggaaa tgtgaaaaaa tataggaaat
|
26581aaagataatg atatgcaccg atcttcaaat aaaYggtaag aactgttaaa cttttcatat
|
26641atttcttccc ggtcattctt tttgcctgga agtttccctg gtcgtgatct tttaatatgt
|
26701atttttttgg gatcttgata tttttaKata cagaaaagct tatgaatttt tcatgttctt
|
26761taaactccta aaaataccca tcctttctaa tcttaaatgt ctctagaaaa ggtttttaaa
|
26821gtcctcYtgt tattgtcttt ctgtaaataa ttactctatc aggacaatgt ataaagttat
|
26881aatattccat aatattccaa ctttgaatgg ctttaattta ttccaacttt acttaattat
|
26941atcccccata gctatggtac agagctggtt catttcccct catgataaga ttttatctcc
|
27001tagcagacag cccttggttc ctttacattg cccaaatgcc ctgctctgtt tttcaccccc
|
27061gattctggat taaattatac caaYatcctt catattcttt cataagttgc taataattta
|
27121gtgtcactat gatggactcc tcagaattct cttccattta tccacactct tattaaaaga
|
27181cagagattaa aactggacac aggactctat tataaaggcc tgatcaattg tgagcctagc
|
27241agagggaaat tgcttttttc ttactatttg tctgctggat gacatatccc tagactatgg
|
27301atgcctttca aattatggtg ctacagctta atttagtttt gacttgaggt atagaatgat
|
27361gctcatatat tttttgtaac agctttatta agatataatc cacatatata attaagaaat
|
27421ttaattttca tgattcagtg ttttttagta tattcacaac attgtgcagc catcaccaca
|
27481atccattttg cagcatttca tcatccctaa agaaaaccct gcactccatt cctcacctac
|
27541cctgtagctc taggcaatga ctcatctact ttttgcctct ataaaattgc ctgttctgaa
|
27601catttcatgt aaatggaagc atatcatatg tgatcattta tgactggcca ctttcatata
|
27661gcagaatgtt tttaaggctt atccatgctg tggcatgtat ctgtatttca tatctttgta
|
27721tggctgcata atattccatt gtatggatac atcacatttt gtttatttat tagttgatag
|
27781gcatttgatg gatatttagg ttgtttcaac tttttggcta ttacaaataa tgctgttatg
|
27841aacattcatg cacgagtttt gtatggacat gtgttcattt ctcttgggta tacacctaga
|
27901agtggaattg ctggggcata gagtaattct agctttaaca cttgaggaac tgacaaactg
|
27961tgtccggaat tggtgggttc ttggtctcac tgacttcaag attgaagccg cggaccctcg
|
28021cggtgagtgt tacagctctt aaggtggcgc gtctggagtc tgtcccttct gatgttcaga
|
28081tgtgttcgga gtttcttcct tctggtgggt tcgtggtctc gctggctcag gagtgaagct
|
28141gcagaccttc acggtgagtg ttacagctct taaggcagcg agtctggagc ttttcgttcc
|
28201tcccagtggg ctcgtggtct cactggggtc aggagtgaag ctgcagacct tcgtggtgag
|
28261tgttacagct cataaaagca gcatggaccc agagtgagca gtagcaacat ctactgcaaa
|
28321gagcaaagaa caaagcttcc acactgtgga aggggaccca agtgggttgc caatgctggc
|
28381tcgggcagcc tgcttttatt ctcttatctg gccccaccca catcctgctg attggtagag
|
28441ccgagtggcc tgttttgaca gggtgctgac tggtgcattt acaatccctg agctagatac
|
28501aaaggttctc cacgtcccca tcagattaga tacagagtat caacacaaag gttctccaag
|
28561gccccaccag agcagctaga tacagagtgt ggattggtgc actcacaaac cttgagctaa
|
28621acacagggtg ctgattggtg tgtttacaaa ccttgagcta gatacacagt gccgattggt
|
28681atatttacaa tccctgagct agacataaag gttttccaag gccccaccag agcagctaga
|
28741tacagagtgt cgattggtgc actcacaaac cctgagctag acacagagtg ctgattggta
|
28801tgtttacaat ccctgagcta gacataaagg ttctccaagg ccccaccaga gcagctaaat
|
28861acagagtgtc gattggtgca ctcacaaacc ttgagctaaa cacagggtgc tgactggtgt
|
28921atttacaatc cctgagctag acataaagac tctccacgtc ctcaccagac tcaggagccc
|
28981agctggcttc acctagtgga tcccgtacca gggctgcagg tggagctgcc tgccagtcct
|
29041gcgctgtgcg ctcgcattcc tcagcccttg ggtggtcgct gggactgggc gccatggagc
|
29101agggggtggt gctcgtcggg gaggctcggg ctgcacagga gcccatggag tgggtgggag
|
29161gctcaggcat ggcgggctgc aggtcctgag ccttgccccg caggaaggca gctaaggccc
|
29221ggcgagaaat cgagcacagc gccggtgggc cggcactgct gggggaccca gtacaccttc
|
29281cgcagccact ggcccgggtg ctaagtccct cactgcccgg ggccagcagg gctggctggc
|
29341tgtcccgagt gcgggggccc gccaagccca cgcctacctg caactccagc tggcccgcaa
|
29401gcgccgcacg cggcccgggt tcccgctcgt gcctctccct ccacacctcc ctgcaagctg
|
29461agggagtggg ctccagcctt ggccagccca gaaaggggct cccacagtgc agtggggggc
|
29521tgaaaggctc ctcaaatgcc gccaaagtag gagcccaggc aggggaggtg ccgagagcaa
|
29581gcgagggctc tgaggactgc cagcacgctc tcacctctca aaactgtttt ctaaagtggg
|
29641tgcaccattt tacattacta ccagcagtat atgaggattc caatttctct acatcctcac
|
29701caacacttat tatctgtctt tttatctagc catcctagtg tgcatgaaat ggtatctcat
|
29761tgtggtttga tttgcatttg cctgatagct aataatgttg agtatatttt ttcatgtgct
|
29821tgtcagccat tagtatatct tctttggaga aagtttactc agctcctttg gccatttttt
|
29881aattgcttta ttttcttttt attattgagt tgtaagctct ttagctcttt cttcctttct
|
29941ttcttgcttt ctttcttctt tatttctttt tttaaggaca gggtctcagt cgcccagcct
|
30001gtagcacagt ggcatagtca tgtttcactg tatcctctaa ctccagggct caggcaattc
|
30061tcctgcccca gcctcccaag tagctaggac tacaggcaca taccaccaca cctggctaat
|
30121taaaaaaaag attttttgta gagacaggag cttgccatgt tgcccaagct ggtctcaaac
|
30181tcctggcctc aagtgatctt ccgatttctg cctcccaaaa tgctgggtct acaggcatga
|
30241gccactgtga caggcctgta agagctcttt atataatctg ggtacaagtt acttaatgag
|
30301atatgtattt tcaaatgttt ttcctctatg ctatggttta tcttttcatt ttcttgaagg
|
30361tgtcttttga agcacacata tttttaattt ttatgaaata gcatttatct gttgtttctt
|
30421ttatcacttg tgttttagtg tcatatctaa taaaccattt tctaatccaa gattataaaa
|
30481acttactcct atgtttttgc ctaagagttt tataatgtta gaccttatac ttaagtctat
|
30541gattcatttt tagttcattt ttgtatatga tatgaggcag gggcccacct tcattctttt
|
30601gcatgtatat atccaatcat cccagcacca tatattgaaa aggctattct ttgtccatgt
|
30661cttacatcct tatcagaaat caattgatca taaatgtagg tatttattcc tggactctca
|
30721atttgattcc gttgatctat ttgtgtatct tcatgcaaat agcactctgt cttgaatatt
|
30781gtagctttgt agtaagtttt gaaatcagaa catgtaaatt tcccagctgt gttgtttttc
|
30841aaggttattt tggatattct gtatcctttg catttccaca caaattttaa gatggggctt
|
30901gtcaatttct gcaaaaaaga cagctatgat tttgataagt attggcttaa tctgtacatc
|
30961aattYgggga gtatctgtca tttcttgaca atattaaata ttctaatcca tgagcaatga
|
31021aatgtttttc cagttattag atcctcttta atttctttca acaatgtttc gtagttttca
|
31081gagtacaaaa cttgtacttc ttttgctaac tttattccta aatatgtatt tcttgatgct
|
31141attctaaatg gaattgtttt atgttcattg ctaatgtgta gaaatacaat tatactgagg
|
31201acttatttga ataagaagtt tcagtgtcag tggattggat gttaaaaaca gatcaaatga
|
31261atatatatat atatatatat atatatatat atatatataa aatgaatgtt gtaattaact
|
31321agaaagccag tggaaccagg cgattatgat agcatgcttt atttatgaga aaataaccag
|
31381ttttaaaaat aactggtttt atgagaaaat aaccagtttt aaaactttaa aaagttttaa
|
31441aataaaattg tggcataata caaaccaaaa agtattttta agtctttaat aataatcttg
|
31501gtcttctctt gagataggct ttttccccta tcctggctgg agttgattat gtagacacat
|
31561tcttattgtc acaattaaag ttgagtaatg attcaaataa gggtgagata agtcttagct
|
31621gaaataaggc tcccttatag taaaacaatt tgatgtttac aaataaacac aaacccacaa
|
31681caatggcagc tagagaaatt aaacaaagag cattgaagaa atttctccaa aacacaaatt
|
31741tatatctaca aataatattg aatgtatgta acaaaagcca aagtagcttt taataagctc
|
31801ttcataaaca ggatcgtgct gcaggctatg cttataaaac acacagcact cctactgcac
|
31861ttattttcaa aatcagcata ttttcagcac acttctggaa tattccgagt gttatgccat
|
31921accagtcagc cccttattat atgtagtttt gttatggatt acctcaagca tatatttccc
|
31981ctgcttcttt ttactgcttt cattatactt catttctcct gtcttccaca atgtctactg
|
32041ctgagtagta gcacagagta agtattcgag ttaacaaaac agtattgagt atcttatgtg
|
32101tactcttcta gataggttct gtgaggaaaa gcaagttcct tcctgctttc caactagtga
|
32161aactgttaag ctatttttgg ccaaaggaaa tcactttgtt gcagttgtct ttcttctcct
|
32221tttgttcatc agcagcttct ctctaattcc tatcctctgt gttggaatgg tcctgccctc
|
32281tagtttatca atgttgaatg caaatataat tagtgttcaa ctactcaaag ttcaaaatct
|
32341atcaaagtct ttatcagctg tatttctagg gatccataga ctattgcttc tgattttata
|
32401tggcacaaat tcattaagag aagtcttcag tgcttYcttt gtaaaagttc ccatgacatc
|
32461tgcttgtttc atgggaatgg ttccttgcta tccagtgtga tggtgggaga gaaccgtgca
|
32521ctgtctatgg tgtcctggag ctggctttta gtggcttctt agaacgaatt attagcatct
|
32581ctttccaact ctgcatccat tgatgttaca ttgttgctta aaattggtca cagtgagaat
|
32641atttatacca caggaattgt taagtgctac tagtcaattc tttttttaaa tatagttgtt
|
32701aaatgttaac cagtccacca ctattagatg aaaactattt gcttctgtat gactccctct
|
32761attgcgctat aataaatgcc tccttgcctg cagccacttc tgctggatga tccattcaag
|
32821Wctattttca tgtaggcaat aaacaggagt tctaaaccat aaacccaaac acaaacgtaa
|
32881gggacaagac atgggccttg gctttaagtt gttaaattac tgccaagcag tttgcgaaaa
|
32941tctcttaaac agaattgaac tgaattgaat atgatcatWg tgttcagttg tccagtcaat
|
33001gtgagaaata tctcttcttt ctatattatt taagagaaaa cagtagagat acacattttc
|
33061aaaaatgttt tgccatcaat aaagcattac aaatttttgt ctataaaaat ggcattaaaa
|
33121ggaactgaaa atgtcaatag ggttgcaaat gaggaatatt agctaccttc aactttacct
|
33181aaaaaatcag atttcataga aagaagtaac atatgctaaa gaaaatttct cagctacaag
|
33241ttattcaacc aaaaaacatt gttatggggg aaaatgttgt tctgcttttt ttaaaggcaa
|
33301tgattttcct gataaccccc aatcccaaca acaacaaaaa aatatggtag acacagaatt
|
33361agaaaaagca caagaatgaa aaaatagtgt cttttttatc tacatgatct tgagccacaa
|
33421tttgtctggg cctgagattt tttaataaaa agtaaataaa attaatggac tatattagtg
|
33481accctaagac atattcccat ggtggggaat gtggtcctca ctggggagag aatggttgca
|
33541tattaaaatc acccagaagc tttatctttg aYttagagat tttgaaaaat ctctgcccat
|
33601cctgttgttc agcatcctta tcttagtgag tcactgttag ttttgggagc tttacttctc
|
33661aggtggaaga gggctggtga acaaactcag aattggtgaa tcagatgctc tcctgtattt
|
33721tttctagttc taacgtacta taacaaatgc ttttagaaga aaattaattt caattcatgg
|
33781actgctagtc cctcagcaat tgttacagat caattcagga agcaagcagc tatgccatcc
|
33841ttgaaaataa attactatgc aagtgaaatc agatagcaga agggaataca attatttatt
|
33901tggaaatgta tctgaagttt agatttatct cttattgaca tacaacaatt tcatcaataa
|
33961atttcaaacc tataaattat tctgcaaatg cacatttaac ttcctattta cattttaaaa
|
34021gcatcgcata acatgggttt cgtattagaa gtacttggcc cctgagatac tgcattaact
|
34081tactcccttg ctgcagaatt cccagtattg ccataactga atactaacag agtgtgtgtt
|
34141ataaaaatac cacagctatt ttcaaaataa aatatgctac gtgaacatta atgaaaaaaa
|
34201gctgaatata atgaacaatg caaaaaagct gacttttcaa actttttttt agaattgctt
|
34261tttctttcca gcatagttta ttatacacac aaaaacgcat acacacagtg gtgcgccaat
|
34321aaaaatttaa caattggctc tgcagggggc aacaaaaacg ccctgatttg tagggtctgc
|
34381caatttccat gttgtaaatc cttcgtgcct gatttcacgt tgccaacaca ccaacaataa
|
34441atgcatagtt gggaagagag gtacagagtt ggccgtcatg agctggtaga gtcagcgcca
|
34501gcacatggct gccctagagc ctctccatca tgcacataaa tatgtcatac agaaatgcat
|
34561cccataatgt gtagcataca tatgatttct cacgaaagag aaagtcatac tacatgactt
|
34621ataactaagt catgaatatt tttcctagat ttaatccaca atcattttaa ctataaattg
|
34681gttaagccag tcaactatag tttagggcat atgtattaca tagataattt ttaattgtta
|
34741aggtagttgg aatggttaaa aagtggctta gccttctcac tcaggtagag cctaagttgc
|
34801atattttaga attaatcatt aacacactaa gcaggcctgc aaaacatcca tgaatatata
|
34861tttcccaaaa tgaataaatc aaacacctga aagctgcaaa cctttatgtg aagcatgaaa
|
34921aaatgccaat agcaagaatt tatatacttt atgcttggcc tgtttatctt catggagatt
|
34981aatagagtga ataaatattt ataataatgg tgtaagaaca tgctgaatag tatactgtat
|
35041taaagttaca tgatcttgtc ttgaattttg tgtttggaat agtactaaga aatatgctga
|
35101gggagaaatt gagtggcaat tttcaaatta atatatattt aYtgagctac tactatgtgc
|
35161aaggcacagc acccaggcac tacatgggac acaaagataa atgcatacag tcttctcaat
|
35221gaaattacaa tcaataMggg ataataagac aagaggtcaa atatttaaca tacagggact
|
35281agtaggacct atagaaagga aagatcctat tatttgggaa gatataaaaa gtcttttggg
|
35341ataaggtggt atgaaaagga aatgaagtaa tgataacttg aactgaagat gaatagaata
|
35401ggttctacta aaatttgtcc aggcccagcc taacatgcta ggttacccgt ggctacattc
|
35461tgttatttct gctgcttaat gagtacatga caatatgttc tggtcattat aggaattctt
|
35521aaaacaagga gtcattctgc cttagcaggt ggcatcttga ggcttttgga ttctgtcttc
|
35581aagtttttta atgagcaaca ggccaaacgt ggattagttt gaagcagctt ctgtggactg
|
35641tgtcaatctg tatgcgaggg tgaatgagta gagagggtgg tatggaaaac aactcctgtg
|
35701attcccttaa ccttctttga ggaagggaaa aacttgggat aaaactgagt attttttcaa
|
35761gtctactggt gagaaaagca tgtcataacc gaattgcatc tgtttgggta tcatagtggt
|
35821ttggggtgta aattagttat tcgaagagta gtatcgatat gaataattga ttaattattt
|
35881cattctacat cttttttcct aaaataattt aggaaaacaa caccctaatc agtttttctc
|
35941aaaactaggc atttgtagcc cccatttttg ctagcaggag ttgaatgtag tttttaaagc
|
36001tgaaaataaa ccaWcacatt ttctaaaact ctttatagtg agagcatagg tcttaggaaa
|
36061aaatatatta gcattaataa gtaaattgtc tcaagtcata ctaaagcaca ttactaggat
|
36121cagtaaaaaa tatatatgca caattgtgta ttagattctg tggctagcaa acgaaaaatt
|
36181ttccaagctg accttaaccg gagcccatct tggtagatgt ttcaactatt gtcacatcaa
|
36241ccttgagaag agttcaaaca ctaagaatga atgagggaag aggtagcggc tgaaaggatt
|
36301actgagctcc acattgactt gatggtcaaa agggcattat ggctctgaat tttgatgagg
|
36361cacatttacc ctttagccca tgttaacatt ttcttcagga ttcattacta ttaaaattat
|
36421ttatgaaaaa gtttttgtRc tggatcatta ccatcagaat aatcagaatg aatgccacac
|
36481tgaatatcaa aagaaataaa actaaaatca ttataaggac acaaccatgt gatatttgtc
|
36541catctgctct ttaagcaatg ttatgttatt tcttgcaacc cctacacaaa ggccaagaaa
|
36601ttacacaagt actagtttat tggttattca cggagagtga gtacctgaag gagaaggctg
|
36661tccttttact acaccatttt tagtcttttc ttctgaattc attacttcct tgtagataag
|
36721ttctgtaaga aacagctgtg ttattataga aaacaaattt atccttcatc cacagggaaa
|
36781ttcattactt aatgccaaat aattacgttt tgatggggtt gagtaaatta aaaatcaRtt
|
36841gagattcctt tactgctcta tttctatttc tatattgcct tgtaattaRc agagagcctg
|
36901gcacaaatag gtatctagta aagcagttga agaaatcaat gcatgaaaat ttatttctac
|
36961gtacatgaaa catactattt atttccatat acatagtatt tatttctaca tacatttcta
|
37021cataaataac atttatttct acatgcatga aatatttcta cataaatgaa acaagtaata
|
37081catgttttac ttgttttctg aattctttgg gggaagtact aatacattct agctcaatct
|
37141agcaacaatt tttatggctt tgaacatcca tttttcttta tacttatttc ctatgaaatg
|
37201cacacattct catgacttta aattattacc aatccttaca acttccatct cttactgcat
|
37261cttttttttt ttccagactc atatcttgga cttgtaaatc taaacttgcc aaaaaccaaa
|
37321cacattaaaa aatttagttc atttactctc agactggcat ccatttttgg ctttctgaat
|
37381gctagagtta aattggatag tttcagttct gtttactctg tccctttagc taaaaatcat
|
37441tccgccctac tcattcttgc tttgcaatgg cttataatct gtataatcat catcctttac
|
37501atgtacttct ttctccaatt tctcacaatt tagtccatgt cctcctcaaa tgatggttat
|
37561atcctatcac ccacctattc atgagcccct aaggagtgcc ttcctgtcct tacttggatc
|
37621aaagcaactc tttttcatct atatcaagca tcttttttca cttgatccac tttttgtata
|
37681tgttcatttt tccatattca ccaacatgac cctggaatct ctggaccagt ggaatctctt
|
37741tagtatcttt taaaattttt ttattttatt ttttatttta catatatata tagagagagg
|
37801cagagacttt ctctgtcacc caggcttgag tacaatggca caatcatggc tcaccgcagc
|
37861ctcaacttcc tggactcaag tgatcctccc acctcagcct cccaagtagc tgggactaca
|
37921ggtgtgtacc actatgcccg gctaattttt gtatgtttct ageagagaca gggtctccct
|
37981atgttgccca ggttggttct gaactcccgg gctcaagtga tcccccagcc tcagcctccc
|
38041aaactgctgg gattacaggt gtgagtcatc gctcctggcc ctgtttagta tctttataac
|
38101attttctgct tattcctgtc ctttgttttc ctcttagtcc tttatctgat attttcttaa
|
38161tattttttct tttcctaatt tacacttatt aattcctgca aggtagctca aatgttcctt
|
38221cccttcagct cttcccattt tgatctgatc atttgctaca atctgcattt gactttctca
|
38281tatttattct attctgtagt gatttagatt agtagattag attaataggc tactcagata
|
38341cacatatttt ctatgtaaat tctcaagtct tatcaatcca atgagtaaac tcatatattg
|
38401actatctttt attttctaaa gtctaaaacc atctcagaat taattttaat ttcatgcttc
|
38461atatgatgat tttatgtaca aacatagaaa gttgtattct ggaattctga actaaagctt
|
38521gccccccacc atgacaaaca ctgacaatca gtaccatttt aaaaggtatc gacaaacact
|
38581gacaatcagt accattttaa aaggtatcaa tggtaaatgc ctttcattct tgagcaaaYg
|
38641tgacattgct ttcggcMtga aaagacagat gaagttttag gagctttaaa aatggtctaa
|
38701gagaatagca gtcagcaaat cattttttag taaattgttt tacaaggaaa agccttgttg
|
38761atactttctg agttcaataa aataaaaagt atactttttt aagtagtaga cttacctttc
|
38821cattcttcaa ttgtgtgttc tctttcatcc aactgcttgt cataYatctg aggtggaggc
|
38881tgccRaataa aaacaaaaaa taatctttgt gtgataatgt aaacataact aaactcttac
|
38941aaYgcacgag aataccttgc cctcatttat ttcggtgatt tcaaccgtat ataagttatg
|
39001aggaaattac agtagttcag aagttaaaat tttcYtgtaa acttaYggag gattcattca
|
39061tattgcaata tttgctgctg acccaatatt gctgcaatat ttgcagcaga acgcaaatcc
|
39121cgagagctca ctttccgaca tcttctgatt tagaacccac gcctaagcaa ttaatgactg
|
39181gtcttttaaa aaacagacaa aacacttgat tacaatgRcc cagaagctac ttttccttca
|
39241Ytcacttgcc ttataacaga accatgctaa aattcttcta ggctaataag attttgttct
|
39301atttttagac cttccctaaa gaaaagttta tatttctcaa cagaccatag tactagtcct
|
39361caatataaaa aaaattgaga tcaaatcaac ctttttattt ttcatgaaat accatagaat
|
39421gtctttatat attgctgtgt gccctatact taaacgattt taagcttttt ggtttgtttg
|
39481tttatttgtt ttaacctgca gaagctgcca tgactgtaga ggtaggtcac cttgaatccc
|
39541tgaatggccc ttggttagtc ctctctagca gaaatgatgc aatagggcct tcagtctgac
|
39601ttatagagcc agcatttctc ttcccatgtg gagttcaaat gtggaaaagg agggattttc
|
39661acaaacctgc gtgcctactg gaaagtggaa tctcaaataa attctctgac ctcttcttcc
|
39721tgatatttag gctttgggag atctaccatg gcggctaggg tagctccaat tcaggccaag
|
39781tgatatggaa agaaaaaaaa aaggctcttg gaaaaataaa tcaccatgag gtagagaaag
|
39841aggaggctga ggggctacac tggctggcac cggtttaagc gcaaagaaga gctatcaagt
|
39901ttttgctacc ccgtccaata ctccaaaagc aatagttttt gtgaaaaact aaaagagtca
|
39961ctcaataaga gtgatgcaac ccctttagga cacagacctt tcaaaaatgg ctattatagt
|
40021aaggaaagct ctggacaaga ttttcagaga cagcttctgg cttctgtgag agctttttgg
|
40081ctcatgaaca gcaccctcgg gctaMagtga cccttctcta attcatgcag aatctgtggt
|
40141agcttgaatc atgacagaca caaatattca tcctagccct ggcatgctgg ggcctcacat
|
40201cctgcaaagt atctggctat gaaaatagaa gactttgccY ggctgtggtg aagtaactta
|
40261gcataatact gaagtattga gaaataacta ctcacggagc cagacattct tttagcacgt
|
40321ttgactgata ctggggcaga aggctgtaaa cctcacctac tgcatttcag atgtggctgg
|
40381ctgagcagct ctcagcagcc gtcagcactg acaactaagc aaaatgagac tctcacacca
|
40441ccccagacaa tagtaagaac acaacacatt gaacgtatat aaggtgacag gactgggata
|
40501gtcaggcact gctctcagga cctgactgag gtagaacctt ccacctctat aaaggactct
|
40561caaataatag aaacattctg acttagtgag tgaatgagta aaatgaagtt atttttgaaa
|
40621aattgtgaaa ccattaccta aggaagctac cacaaagcca aactctggtt ttgtaaagac
|
40681gctttgccaa gtggtaaatt tccggctttg cctcttcctg agcatgtata atgctgtggt
|
40741taggccgcta tccaagcgac cttgtccagg acccctgcag gacacagtgt acataagctc
|
40801tcagagcccc cagagccctc tgagctgttg gcacctcctt cttcttctaa caatagatcc
|
40861agctcatgat cctgcctggc tggcttctcc atgcagtgga tttttccatt caagttttaa
|
40921aattgaacat ggctcaagag tacagttcct gccaaagttc ataaatgcca ttttcttttt
|
40981gcaacaaagc tattttcagg aggtttccct aggagcctca gtgtacagct gttgctgata
|
41041tataaagcac aaagtacata gacactaatc acaaacaaac tacaagagag aatgcaaagt
|
41101gctgagttca agatttttcc tttcaacaaa ccaagagggc tgctttaaac cacttgattt
|
41161aYagtatttg ttcgacggcc tctgcaaatt tactacatat tcagattttt gattgtttgt
|
41221tttttgaaga ggaaatgcga atgtcacctc cagtgaaagg gcacattcac atacagatgt
|
41281cttctatgtg acaatataaa agaataattg accaataatc cagagagagc aatgttacaa
|
41341cacacacgta taagtgctgg gcagcaatca tcaggatgag atagttcaaa acattccctg
|
41401cctccttccg ctaaggagaa gttggtattt gagcactcgc ttgtgctctt tccctatctt
|
41461atttaatagg aattattctt ttgctaagtg acaatctaaa taaaaaataa atgaggagtg
|
41521gggataaaga aaaatgcccc agaggtgtct gttgagagag tattttagga gagtttagca
|
41581gataagagta attgagatgt gagaaatgaa ggataagagg acattaaaga tagtatatga
|
41641acagttatca gggcctgtga ctttcaccct ttgaatattt tttcaaaaga ctgtaaactt
|
41701ctttcatatt attttggaag atttgaactt ccttggttga aattattgca gaaattcaaa
|
41761cacaaattta tatggattgc ataaacaata acttaaaatg gattagacac atttttattg
|
41821atggttaatt tcatatgaat ttatattggt ggtcaattat atgaatttta tactgatgaa
|
41881acatgtccaa attgtttcaa ttaaatgagg aaaaaaacac aaacaagtac atggtcactg
|
41941tgaattaata aatactagaa tttatttatt tctttattaa atgtattcat tcagtaaagg
|
42001tcttgggcac ctaacacatg gcagactata taaaaaactg agatttcaaa attgaataag
|
42061gtgactgctg accacaagga gttcacaatt tactggggta agactgatgc aaaacagatc
|
42121attagtatac aacatgataa atgatagaaa cctgtatatg gtctaaggga acagggtgga
|
42181gaagtcctaa caaagcctag atttgatttc ctggagtaaa gtgatgctta ttcagtgagc
|
42241gaaagatgtg tgggaggttg tcaagataaa agaaggagga aaaaagtgac tccatgccaa
|
42301gagcacatta taagccaagt tacagtatgt agaaaacaga ataggggtgg tggtggtggt
|
42361ggtggtagtg gtagtggtgg tgcatgtgtt tctctgtgtg tacatgcatg ccaagaaaac
|
42421aagaaggaat tttgtcacag taaaataaaa catgtcgtca gaagtgacaa gatataMgag
|
42481ctgtacttag agaagcagaa gggtcagaca aagggtggat caaggatgat ccagggggcc
|
42541aggcgctgtg gctcatgcct gtaatcccag aactctggga ggccgaggtg ggtggattat
|
42601ttgaagtcag gagttcaaga ccagcctggc caacatggtg aaaccccacc tctactaaaa
|
42661atacaaaaat tagccgggca tggtggcagg cacctgtaat cccagctact cgggaggctg
|
42721aggcaggaga atcgcttgaa cccgggaggt ggaggttgca gtgagcccag attgtgccac
|
42781tgcactccag cctgggtgat agagtgagac tctgtctcaa aaaaaaaaaa aaaaaaaaaa
|
42841aaatgatcca gggtatcatg atacggaaga aagaagaaga gaaaccactg aggaatgtaa
|
42901gagaacggaa cagtgaaatt tacagctgga ttgaagaaag atgtaactgt aagcagagag
|
42961aagaggtagg gagccattgc acgatctata aaaaaatatt gaaagttctg actgcggtta
|
43021aaaaaaaaaa aagatgaggg tgaacgaaag acacagattc aggaataatt aataaatgtt
|
43081aataaataaa cttggtagaa gttggttttt gattgaacat atgtgatggg agagaagaat
|
43141atgagtcccc aatttctaag ctgagtacct gggaagatga tcgtgttggt gaagccatct
|
43201aaagaaatag agaatggaaa aggggaaatg agattggtag aggtgagcct aagtgttatg
|
43261tgagaagaga tgatgatttg aaagttaagt atataatctg aagttcagag gaatgctgtt
|
43321ggctagagat gtgtatagat ttgagactaa cagcaagtga tgtttgttga aactatgaca
|
43381gtggatgagg tcacccaggg aagatatgtg ggtatagaga gtaaatggcc aaattaaaat
|
43441ttaaagattg gacagaggaa ggtaagttca ctaaggcaaa agagaatagc taaagaaata
|
43501catgaaaaat gagaatattg caatgttata gaagtcaagc aagtagaatt tcacaaaaag
|
43561ctagtaattg gccatttctt gcaaatgaag cacatgagga ttttgactcg cagggcacca
|
43621gaaaggcatg atagaaagca tgcctctgaa ccctttgaaa gctttccaaa ctttaaattg
|
43681ctatcacccc cagaaagatc cagatagatc ttcggtggag gacgttaata tgagacatca
|
43741cctaaacaat tgaataaaat gtagaaaaag atcctcaaca ccaatataat taaaaggaaa
|
43801gaaaccatag aacaattgtg acactagaaa aactataatg atctcagatc tactctctca
|
43861agtctctgag aacttgataa aaaaaaaaac actgttctct atctagttaa aggaagtcac
|
43921tttttttctg agaaaccacc atatgttaag ctgtctttat atagacctta ataatcctca
|
43981cagtcaggaa actaagattc aaggaaattt taaaaaatat atcatgaagt catatagcta
|
44041attaatgatg aaacttttat taaaacccaa tttaaagagt aatccagagc aagtgtcaat
|
44101actgttgaat ctaaaataaa gactaataaa acaatattta aagtgaacat ctttgtaaaa
|
44161caagaaatag aaacataagc caatagggtg accatatttc ccagtttgta caaaatagtt
|
44221ccattttatg cttattgtcc ttgtaattat tagtagcact tacgcccttc gctcctttaa
|
44281gtgttgtggt ttggagaata aatatgtgga cactctacat agcaatgttg tgacatggca
|
44341tgttagagat ctaaggtata cagtaatttg aggacaaaga aaacaactga attgcaatgt
|
44401ttttctacca ctgaggtttc aacaattgca gctgtacctt ttccttctct gagacagcac
|
44461gtcagcattt ccttccattt tctctatttt tagaaacgta aaattcagct ataaaatatg
|
44521gctgttggca gacagtacag acaagagtag aattctgcat aataaatcta tagttgaaaa
|
44581atatggattc tgtgggcatt ctatggagtt cttgctgttg gccatgactt tctactaaag
|
44641cgatctcttt aacaagtacc tgttcaattc ctaattgagc tttcgaaggt aaaagttgct
|
44701ctttctgcct gtaatcccag gcctttggga ggccgaggtg ggcagatcac gaggtcagga
|
44761gatcgagacc atcctggcta acacagtgaa accccatctc tactaaaagt ataaaaaatt
|
44821agccgggcat tgtggcaggt gcctgtgttc ccagctactc gggaggctga ggcaggagaa
|
44881tggcataaac ttgggaggtg gagcttgcag tgagccaaga tcacaccact gcattccagc
|
44941ctgggtgact gagcgagact ccgtctaaaa aaaaaaaaaa gttgcccttt cttgtgactt
|
45001cattcatttt atcccatata tataagtaat attcattgag taaaatgtgt gaatttattt
|
45061tttactgaat ctttgagata attttcaaag atacatggga agtatctttt tcaacagcat
|
45121tataggatat tagtggtaaa agaaagttca gagattatct aatgccaccc ttattcaatt
|
45181ttcaaatgag aatatagaaa ctgagaaagc ataagtgatt tgcccacaat cacagagtta
|
45241attagtgaca gatgaataca tttatggtct cttatgggaa aagacagaat aatggaattc
|
45301ttatggttga agaaacttta aactggataa tttgacacct gtaaaagata ttcattaaag
|
45361acaaatttgt gcctgccaca cactgatttc tgttccaatt ttctgtcagt ctacacttac
|
45421agctagagct ggcaactatc atacaagcag tcaacactta cattcttaaa cacttttttg
|
45481tcaaagtatc atggacatca aagacctcta aacacatgaa tctctaaaga gataaaaacc
|
45541agatatgaga aatctaagtt gtacaaagtt gttcctttga ttcttctttg agccctgaac
|
45601tgacattttt ccctaacact tatgctctga accatatgac agtccatcaa gttgttggtg
|
45661tttgtctgct ttgtcctaat taaggatctc cctgtgttct gctgccttgt ttaaaatgtc
|
45721aacaaaagct ttaaatagca ctgtatctca gtgtgtgcac tcattattaa ttcaacatct
|
45781ggatcaaagt aaatgatatt atatcttact gaaatatgct ttgttttttc ttattaagct
|
45841tggcagttag atgattgtca aaagatgcat gctttattaa aacgctttaa gcaagaaggg
|
45901tatatcttag tacaaaatta gatagaacag gaaatccatt aaggaaatat acaacatttt
|
45961gattttatat ttccttgaat ctctacacat agagttttct aatttttttt ttcttaattt
|
46021gatgactagg acttgttaaa ttttcaccaa ttaattagaa aataaaaatt ttggtaaaat
|
46081gactctgatg aagcacaaaa tgatatgcac ttttattgtt ttatttggct aatggcacag
|
46141tttagcatgt ccaatttttc tctaaagcct tatattctct gtggcaccaa Sagcagttca
|
46201ttaccccaaa atggagctca gtatttgttt cacaaatagt cttaccaaca atcgccaaaa
|
46261taatgaaaat attattgcaa tatgcacaat tatcaaaaga attgattaga tataattaat
|
46321tcctatgatt tctcagtaat gtgaccttac tatgcattaa gcaatgacct ggtttccaat
|
46381taccaaaaac ttcattgcct tctgaatgta gatatatggc attttgtgat gtactatccg
|
46441ttgattatta aaaattgctt cagcaagttt caggaactat gtctgtgttc tcaaacagaa
|
46501attaaataat atactactac agattaaata aatgcctttt aaaagtatga tttgaggaga
|
46561tgtcagcaag atgataaaat aaggctctcc agtgctccct ctctcacaga aacatcaatt
|
46621tgaacaacta tccgcacaca aaaatacctt cacaaaagtg aaggaaacca ggtgagagat
|
46681ttcagcacct gggtatagca cggaaacaag aaaagatgca ctggagagag aggaaggaca
|
46741gtttcacatt acctgcttca cttttccccc aattaccaga cagcacagca tggagacaga
|
46801taccctccac atgatggtag gagaaggaag tgagcatcag actttgcctt agaccccaac
|
46861actgggcctg ccacagaaaa acccagcacc aaagagaccc tcacagccct agacaccagg
|
46921ctagtacttg tggactgagc ttccacacct ttcccagcac tgatcagggg cttatagcct
|
46981tagactcaag gtctatacag cagacttggt ctctgggcca ctctactgcc aggtctacct
|
47041tagcagccca gcctctggaa cttctccagc actgggctgt cccctataat cctggacatc
|
47101agatccatcc cagtaactga ctatttcctg cagactcaga ctcaaagcca atcccagagc
|
47161caagtagccc cctgtggacc caaggataag gccagcctct acagatgtag gcaaatattt
|
47221gcagacatag gcgtcaggtc tgcccttgtg tacccaggtt tcaggcctat ccatggggac
|
47281tcaatcaata ggtccacact tgtggatcta gacttaggcc caaccctata gacccaccca
|
47341cctgctgacc caggcaccca gacaccaagc ccagccaacc tacctgagga ctccaacagc
|
47401aggcctaccc ttagacgaca ccaaatggca tgcacaggtt ctatggaaag gctgactgat
|
47461aaagagtttt cccagacaaa gccagtctgc aaagactgga ataagccctt acttcttcag
|
47521atgcacagac atcagtgtaa ggaaataaga aacatgaaaa gctgaggtga cataaaccac
|
47581caaaaaaata caaaaatctc ccagtggctg agtcaagaga agtggaaata tataaactaa
|
47641gagacaaaaa agtcaaaata attgttttaa ggaagctcaa caaacttcaa aaaaattaca
|
47701gggaaacaat ttcataaaat caagaaaaca ataaataaaa caaatttaat agagagattg
|
47761aaattatttt tcaaagacaa agagaaatcc tattgccgaa tataatgaat gaatgaaaaa
|
47821tgcaatagta ggattgatga aggagaagaa agaatttgta gccttgaaga caagttattt
|
47881aaaaatatat ggtcagaaga gaaaaaatga aaacaaatag agaaagttta tgtgatttat
|
47941gggagagcat caaaagagca cattttttag ttcaagaaga gaaagacaaa ggggtaggaa
|
48001gtatgtttaa ggaaataata acagaaatgt tttcatatct tgggaaagac atattcacgt
|
48061agaggaaagt taaagttctc taatcagatt caattcaaac aagattacac caagatatat
|
48121cataatgaaa tcaacaaaaa tcaaagacaa agaaaggatc ctaaaggcac caagagaaaa
|
48181gaagcaaata acatttaagg gaatgttcct atcaagctag cagatttttc ggcagaaacc
|
48241ttacaggcca ggagtgtatg ggacaacata atcaaaatgt taaaataaaa taaaaaaact
|
48301atcaattagg aatactgtac cccacaaagt tgtccttcag aaaaggagag ataaagtctt
|
48361tccacaacaa aagttgaggg agttcaccac cagacctgtc tcacaagaag atgcttaaga
|
48421gagttcttca ggctaaaaga aaagcattct aattagtgac acaaaaacat gtgaaagtgt
|
48481aaaactcact tacaaagata agtacacagt caaactcaca acaccctaat actgtaatgg
|
48541tggtatgtaa ttcacctata tctttaccat gaaggtgaaa agaaaaaaac tactaagaat
|
48601aacaatagct acaataatgt gttaaggcat ctacaaccac ctgatcttcg acaaacctga
|
48661caaaaacaag caatggggaa aagattccct atttaataaa tgatgctggg aaaactgcct
|
48721agccatatgc agaaaactga aaccagactc gttccttaca ccttatacaa aaattaactc
|
48781aagatcgatt aaagacttaa atgtaaaacc caaaaccata aaaaccctag aagaaaacct
|
48841aggcaatacc attcaggaca taggcatggg caaagacctc attactaaaa caccaaaagc
|
48901aattgcaaca aaagaaaaat tgacaattgg gatctaatta aactaaagag cttctgcaca
|
48961gcaaaagaaa ctatcatcag actgaacagg caacctacag aaagggagaa aatttttgca
|
49021atctactcat ttgacaaagg tctaatatcc agaatctacc aaatttacaa gaaaaaaaca
|
49081aacaacccca tcaaaaagtg ggcgaaggac atgaacagac acttctcaaa agaagacatt
|
49141tatgtggcca acaaacatgt gaaaaaaagc tcatcatcac tggtcattgg agaagtgcaa
|
49201atcaaaacca cagtgagata ccatctcatg ccagttacaa tggtgattat taaaaaggaa
|
49261acaacagatg ctggcgaggc tgtggagaaa caggaacgct tttacactgt tgctgggagt
|
49321gtaaattagt tcagcaattg tggaagacaa tgtagtgatt cctcaaagat ctagaaccag
|
49381aaataccatt tgacccggca atcccattac tgggtatata tccgaaggat tctaaattat
|
49441tctgttctaa agacacatgc acacatatgt ttattgcagc actatataca atagcaaata
|
49501cttggaacca acccaaatgc ccatcaatga tagactggat aaagaaaatg tggcacatat
|
49561acaccttgga atactatgca gcaataaaaa agaatgagtt catgtccttt gcagggatat
|
49621ggatgaagct agaagccatc atcctcagca aactaacaac tagcacagga acaaaaaacc
|
49681aaacactgcg tgttctcact cataagtgag agttgaacaa tgagaacaca tggacacagg
|
49741gaggagaaca tcacacacca ggacctgtca gagggttggg ggcaagggaa gggagagcat
|
49801taggaccata cctaatgcat gctgggctta aaacctagaa gctgggttga taggtgcagc
|
49861aaaccaccat ggcacatatt tacctatgta acaaacctgc acgttctgca catgtatccc
|
49921agaacttaaa gtaaaatttt aaaaaaaagt gttaagggat acacaatata aaaatatgtt
|
49981aattgtgaca tcaaaaattt taaatgtggg aggaatggtg gagtaaaagt atagtttttt
|
50041aaaaatgcaa gcaaaaagtt gttatcagct taaagtagct tgttataact ataagatgtt
|
50101tttgtaattc tcatggtaac cacaaagtaa aaatttatgg tagagacaaa aaagatacaa
|
50161agtagggaat caaagcatac caccagagaa aattatttta tcagaaaaaa aagacaaaaa
|
50221aagaggggaa gaaatgaaca aagaacctac aaaacaacca gaaaacaatg agctaaatgg
|
50281cagtattaag tccttaccta ttaataatta ccttgaatgc aaattgatta aattttccag
|
50341tcaccttgga tgtgaagggg gctgagggaa tagaaagaaa agactccaag gtatctcatt
|
50401atccagatga aaacctggat agaaagtagt gccatgaatt ggaaggagga agcatagatt
|
50461tggtgtRgag aggagatatg gccagtttaa tatttaatat gttgattttg caatgccaat
|
50521ttcaattcca gtgactgtta gatttataca tctggaactc aggccagctc tatgggacga
|
50581tgtgtagaat tgagccattt atgataatta aaattaaggc tgtggtggaa gataagactc
|
50641ccagagagaa aagaaataag ggctataaag aaaaaatttc tgagatgcac aattctaagg
|
50701gaagagagaa caacccacat tgagcaatgg aggctgcagg agaacaggtg tgctgccacc
|
50761acagaaatta acatgcaggg gtgcagaaag gaaggtgttg tcagcttatt caaatgggca
|
50821aatacatgag atacccattt ttttggactt ggcacctaag aggccactgg tgaatttaga
|
50881gaaagcagtg tcaatgttta aaaagtgaac tggagtaatt gtgagtaaac aaggactaat
|
50941gttttataga gacttggcta taaagctata agtcatactt ccattgctaa aggtagaagt
|
51001gtagttaaaa ataaaggttt gctttgattc tttgttcttt gaaatgaaag agactagaac
|
51061atgtttattt gtaagaagta attgccactg gaaactgaaa cataggacac acacagagaa
|
51121ggaagagacc cacatgcaga aaacaaaggc tataaataaa agagtacagt gtcctgggtt
|
51181ttcctggatc ttgtgtaaat gactccatca cagcattatc atgttttctt ctcaacatct
|
51241tcatcattct actaccattc gtagaaagtg gattttcata tattatctca tttagtcttt
|
51301gtgacaaacc tcctattcca agtatgcaac tgaggcacac aaagatttaa aaatctatga
|
51361gttagtagca gaggccatat ttaaacccaa atctaactga atacaatgtc tgtgttcttt
|
51421gcatttttcc accccaggct tatagttcct actaattcaa cctattgaaa tatattttaa
|
51481cgttttatta ggcaaacaaa gcaacagaga acagcaggga aaaaggcgac tttatctcta
|
51541gctgacgggg ctcttgaaat gctgttaatc aggattctag atacaaattt ccacgtccac
|
51601tcagaggggc gagaatgtgc aatatattgt gatgctgcca ccttgtggca agaaaaaatg
|
51661aaaacattaa gaggtgcttt gtgtgcatat ttatcatttt caattaaatt gctctagttt
|
51721atggttcagc tacggctgca cattgaaatc atctgggagt tttaaaaata ctgctgccta
|
51781gatcccacct cagagattct gatttaattg ttctggggtg aggccttggt gtcaggatat
|
51841ttttaaactt cccaaatgat tctaacatgc agcaaagatt aagacctctg ctctaaccac
|
51901ttatacagta gagaagcaag tcttgtcatt tgcctagtta tgtttcattt gtatagacgc
|
51961aaaagaaaac attctagaga aagtaggtga ttttctctca atctttaatg gcatctagtt
|
52021cttggtagaa tacaatgatt tctggacaga tatatcatat actatgattt taaagaacag
|
52081gacaaagaaa tttgtgaatt gtaatcaaag tggacacaag atttgtgtct cataatcaaa
|
52141tgcagtccgt agactaaagt gagcagggag aatctctgag cctcataatg cgtcacaggt
|
52201tttctgaaag gaacaatgga aagagcactg aagcaccatt gactctggca ctagtaagat
|
52261gagtgacctt gagcaagtca ctcagtttgc aatgaaagat tttcatctac tgctttattc
|
52321aagagaaact agttccaaat gttcaacaaa tatcatacca ggtaattcaa caaaactttc
|
52381ttaagtactt gcaatgcgaa aagcatggaa ttataatgtg ttataaatgg aaagcactaa
|
52441tgttgcttag agacatcata gcattaggtg accagaggaa cctttgaaag ctagtaatgc
|
52501aaattttaat tatgatctga actgagtgta attagaaagc ttaattacat aatgctccag
|
52561tggtttggca aagaagttga attcagtttt ctctattttt cattctgttc tgtagttttc
|
52621tcagatttat ttattagctc tacaccatca aaaagtgtaa tcatgtcttg aaaatgaaat
|
52681ttctctttcc tgctccttgg aaattaaaat tttctatggt tctttaactg aaaagtttca
|
52741gtaattgcac caccaatcac ccagtgcctt ggtcaggaat ctttctttct tcattcgttc
|
52801atttaacaca tatttattaa ccctctacca tatgatatta ctcatctttg aattccacct
|
52861cccttaaatt ccaaatttaa ttatttacaa ttcatgtcaa ttattagctt ctaaacatct
|
52921cttgaatatt ctgYccatgt ctacagtgat ttagattact acagatctat cctcctgcct
|
52981tctagctccc ttttctcaac tccagtccca cactgcagac agtggccctt tgaaacttca
|
53041aatctgctaa tgctattgcc ccacttccta gtgaatggct tcccttcacc ctaggatagc
|
53101atgcatggta catgacaatg cttgggaact ccttccttat ctggtccctg cttaccagcc
|
53161caaaataatt tctcaccctt ctccattaag tcactcagaa agcttaaagc tttgcaattc
|
53221tctccaccct ctcttgaccc tgggattttt gcatataccc tttcttctgc ttgcctttct
|
53281tcacttggat aatttctttt ttagcccttc atgttcctgt ttgaaaatta atcactccaa
|
53341gcagccttct gtaacccaca ttactgggtt atttttatgt gtttccaatg tacaataagc
|
53401ttaaaatttg gaatacgtat catcaacatt tacttattta tcttctcact agaccatggg
|
53461acaaagaatt gagaataaaa gacctaggaa tccaacttac aagggatgtg aaggacctct
|
53521tcaaggagaa ctacaaacca ctgctctcta tttgtctgtt attcgtgtat aagaatgctt
|
53581gtgatttttg tacattgatt ttgtatcctg agactttgct gaagttgctt atcagcttaa
|
53641ggagattttg gactgagatg atggggtttt ctaaatatgc aatcatgtca tctgcaaaca
|
53701gggacaattt gacttcctgt cttcctattt gaatacgctt tatttctttc tcttgcctga
|
53761ctgccctggc cagaacttcc aatactatgt tgaataggag tggtgagaga gggcatcctt
|
53821gtcttgtgct ggttttcaaa gggaatgttt ccagcttctg cccattcagt atgatatttg
|
53881ctatgggttt gtcataaata gctgttatta ttttgagatt ttgggctgag acaatggggt
|
53941tttctagata tacaattgaa aatctagaag aaatggaagc acagtatata gtacatagta
|
54001gatatccaac aagtatgaac cattgatgaa gaacaattat ttgcattcaa aaatctacga
|
54061tatattaact cggaaaaatt ggtcaggtaa agagatgaaa taaattatga catgtctgac
|
54121attactcaaa taatttttaa aaagtagatt ccagcttttg atatacacat attagccaca
|
54181caatcatggg caatgtgctt aacatccatt aacatcctga gctttagtgt cttcaattct
|
54241aaacacagat acattcattc agcaaatatt gattatatga ctactaaggg ccagacagtg
|
54301ttctaggtag ttgggataca gcagtgcccc aaagagtcac tgtctctctt tttacgcatc
|
54361ttaaattcta gttgatgaga cagataataa aaagagatat ataatgtcaa acagtgacac
|
54421atagagaaaa aagattaaga ggctagagtg taacagagta ctattctatt ttttcttttt
|
54481agtttttttc tttttgtttt tgttttactt tttaaactat tattagtatt atttttacaa
|
54541acacttgtac caagggctga ctttcaatag atcacagcaa ggatcccctc tgctacatat
|
54601gaaaccctga cccagaagca ggtcatctac ttatgtttta gtgccaggtt acacacgaat
|
54661gtgtgttaca tgacgggcaa gggggcggcc gaagagtact attttagaaa ggatggtcat
|
54721aaaaggcttY tttgagaagg taacatttga gcagagattt gaatgaagta aaggagggag
|
54781caatgtgaat atctggagga agaatgtccc aggcagaagg aaatacaatg caaagaccct
|
54841aaagggggag cttgcttggt gtggtaagga aaccgcaagg atgccatata ctggtgcaga
|
54901gtggaaaagg gaagcctaaa ggtgatatca gaaaagtagg caggagccag actaagtaga
|
54961gccatgtttt ccaaactgca gtcatgaaaa caaattggtg tcatcactag caccttttag
|
55021tgtaactaag aagagtaaaa tgagatagaa aatatcagtg tatggttttt cttttgtgtg
|
55081tgtgtacgtg tgtgtgtgca cgcacgtgca cttgtacacg catgctgggt tgcaatgtaa
|
55141aacacccttc ttactatggg ttatgataaa atttgaaaca acactgtggt agggccttgc
|
55201aagccatgat aagtactttg agttttgtta taaatatgat aagaagccat tggaagatgg
|
55261gaaggtgtta gctgaggaat tatgtgaatg taacgtgttt tacattttaa aaggaaaatt
|
55321ctaggcattc tgcagaatgg accacaaggg acaagagtgg tgctgagaga taagtcccag
|
55381aatattacat ggtccagggt agaaatgatg tttgcataga tgaaaggatg agaagtgatc
|
55441tgagtcaagg tatatttaga aagtaagttc agttaagagt tgttgaggat agtcatcatt
|
55501ttctagagtt tttatgaggc ttaaataaga ttggatatca gaaagggttt tataaacact
|
55561agagaagtgc tcagcagagt acagctgagt tcaattcaaa gggcatttac tgaccataca
|
55621ctatgcacct gccattactc tcactgtttt ctctgcactc ggtagataaa actgaatttc
|
55681tgctcccaag gaactttaca gcagtagagt tgtggaagat agacataaaa atgaatcact
|
55741gcagcataat gcacaatatg ataatggcat atggaaggtt ctaaagaaaa tgagttaact
|
55801taaaattctg agaagcagta gcttttgttg caagcctttc ttttcatagg taaaagatca
|
55861cattagcccc aaggatattc tgtaggacaa atatgagcta aaaatgaact agaaaatagc
|
55921tctaggtgaa aaacacatcg aacacagata ttgctgagtt agtctattaa agccacatgt
|
55981catttgcact tttgccctac agtcacaaaa caaaagcaaa tgaacaaggg aaagaggatc
|
56041ttcagccctc ctacataagt aacatgaatc aataaggagt catcctggag accacagaaa
|
56101accacactct tccagttagc atcaatgaat agccccagga tacaaatcca cagtgaatga
|
56161agaaacatag ctacagaatt agaaacatta ttaaggaaaa ttgatttgag tatacttcac
|
56221taatgttaga gggataatat tatattttag gttgaaatgt aataattttt ttaattccaa
|
56281agtgtctatt aattttaaaa tatacatact ttttgttaca aatatttatt tttccccttc
|
56341ataccactaa tctctgtgaa aaagtttaga atgtgacata aaggttctag gttaatgaag
|
56401tctttcaatc aagcataaag acttctgcta atctagtaaa aaccgcccct tctacctaca
|
56461tggattcaat atatttgttg cattatataa gaaagcattt gtgtaccaca tttacatatg
|
56521agatgtttat cagaaagaaa gtggtgctct gaggagaggg agatggggaa cagaatcact
|
56581tgagagtgag gatttatttc caattaatta acatgcccac aagaatctgc cataccccac
|
56641atgaagaatc attgctttaa tatagattga tgagttgata acgttaatga gttgatgact
|
56701gtctctcagg tatgttgggg aacaaaaaag tttgagaaac aaatacagtc ataaagaact
|
56761atattctaat aataaggcgt taccattgct cctacttttt aatgtattat atacattatt
|
56821atataatact ttttaatgta tttaataaat atatctcata gtggattttc ttaaaacaga
|
56881gcttgccttt tcattaagta attactccaa ggagtaattt taaaagaaaa taagtctaac
|
56941tgagcttttg tgttaacatg ataggaactg ataacatttc catttttctt atgtcacata
|
57001gactaaaact gttcagttta aaatagttca attacctcca taagctttaa gaaaaccttc
|
57061tttaataaca tcctatgttt tcaaagttaa ttgggtactt tcacattttt ttcctttaaa
|
57121acattattag acaggacatt tcatgggtaa agattagtga tgcaattata ccaccatctc
|
57181tgaatgtcat tctttcttca tctccattgc cattgaagtc cattttgtca tcttttattt
|
57241caactacttc actagcttcc taaatcatct ttctactatt ttatcacttc atcagtcaga
|
57301aagaatgatc tacctaaaac acgaatccca ttgtgttact ccctgattaa aatctgttcc
|
57361cccaagcctg cagcttgggt accctctggg aatgacttaa aaggtgtttc ctgaccagga
|
57421ccctgcttac atttccagct gcatttctca ccattccctt ccctgctcac agtgaattaa
|
57481ctcatagttc cccaggtgtg tcctggttca tcttctctcc tggccattga gcaggctgct
|
57541tcctttgcct accagattct actcttccac ctccatttca cttggtaact cttgcccatc
|
57601cttttggtcc catttgaggc ttttcttcct cctaaaaacc tcctatgtct gctataggat
|
57661gagttatgcc ttattccttt gtgtttctat ggcactagta ctatggttat agtatcttac
|
57721ttacttacat attaactcta ctacaaacta ctaaataaca gaaactatgt ctttttatca
|
57781ttagaattag tcaatcttca atggcagcgt acacttgaag cttaacaaaa gtttaagtga
|
57841atgaatgtgg tggacctgtc caaggtatga tgagactttg agtccatgtc ctctaattgt
|
57901tgacccacag tggtttccac tgtgctctac tgtctcccag tgccatgacc ttggtctcca
|
57961cactctgtaa ctcttggtcc tcctcccatt gtctgtctac agtcctttgc tttgggaaag
|
58021ctagactaag taaggcaata ttttaaatta actaattgca agccaagttt tttgcctgga
|
58081tttgagctta gccttccatt cttgggggag ctattcatta cttaagaaaa cctacctgtg
|
58141actatgcatg taagaattct ggctaggaat aaactattgt tcatgattaa acaggaatgg
|
58201tgcaagaggc atgagcaggc ctacctcaga aaaagaagtg gtaacagatt gctgtactat
|
58261gaaaacagca ttctggcata taYgtcctga aagaaagtca ccaaaagttc tttacgctaa
|
58321cttagtcaaa aacaacacat accttaggta agaaattttc agaaaaagtg cttgaggStt
|
58381agctaattta tctctcactt tttacagagg aacatcgaag gaattcagct ttcaaaatgc
|
58441acctaaagat agaaatcaga ttcttcttgg aattagaaac tgtggggagc atcttttgat
|
58501tgttgattga actcatgttg ttttacatac attatattct ctttcacaat atattgtggg
|
58561tcattattct acaaacaacc ctctgagtct catatgaaac ctgcagcaag ttatggaagt
|
58621ggcttttatc attcttacaa ttgccctacc attagaaagg gacataataa ttttattata
|
58681gcacatactc ctggaaagac cataaacttt taatagactt gtaaaaaggg agtgtaacct
|
58741tttcaatatt ctgtctcatc tattctacct tctcctcaca tataacgaat gccctagggc
|
58801ctaagtcatg gatctacact tgggaagaaa atgttgagat tcagcctttt ccctgaatct
|
58861gaaggttacc atgatttagc acccaggaat agtttctgcc tatccttttt ctggttcttt
|
58921tgcagctctg caacttccag acttgtggtc tatgtagagt tgtgatgaca ttccgacttc
|
58981atgtctatag ctttcattta gggattttta aatgtcagca taaacatcct acagcgttta
|
59041aagttgtctt cacatcacca cacatattca ttttcagcat cattaatgat tacactttct
|
59101gattattttc ctttctctgc tagactgtca aacttcttag tttacttcct aatattgata
|
59161gcatcaccag ctctaagcat gacttctcaa acaagatgtt tggttaattt tctgtgtgtt
|
59221tttgttgttg ttcatttgat cgtctcaact ttttgttgca atgcacaaca taaccacctt
|
59281cttagatcat ggacaaagaa acaaacaaaa atctttggag acaaacatgg cagaggaaaa
|
59341taaatatcgc aaaggaagtg agtgcttccg aaaaacaaag tggaaacaaa gtatgaggaa
|
59401cccctgaaag cctcacagca taagaaaaga actagctact tgaagagtag acagtggcta
|
59461ttaatttcta tttcttgaaa aaaaaatacc attttaaaat tgtcRgggac cacaagaaac
|
59521tgtttttata atgttaatag tttttttaaa tcacaataat aaaaattgaa agcataatat
|
59581tttacattta tcagttactt ctgcctccac cactttcctt aaaaaaagta ggacttttac
|
59641agatgaaaga gcattttaat acaaatttta aaattacccg aagacaataa attatttcct
|
59701aaaacgtgta ttaaatcttt ttgttatgtc tataaatgat aatctagtct aagagtaact
|
59761tatcagcatt tttgcagtcc cctcccccca tccactgaaa actttcttta ctagactcat
|
59821gattttcaaa attttaagaa ttaaatttgg agtaaaggaa ctccgaagat ctgaaaaagc
|
59881ctgtgaactg gatgtccaga aagatgtaaa tacataatta ttgatagaaa attttgggat
|
59941gtttttcaaa agcccccaga agttcctcta aggaaccctt aggggtcata ggaaagctca
|
60001gtgctgggta gtgagctcct aagagcagag aaatgccctc ctgtgtgcat ctctagatct
|
60061ggtacagttt cagcattcat aggggtgcta taaacatttg ttacgttgaa tcatggagga
|
60121taagtatgta tatactcggg tgttgttgtt gctgttgttt gagatagagt cttcctctgt
|
60181cacctaggct ggagtgctgt ggtgcaatct tggttcactg caaactccRc ctcccaggtt
|
60241taagccattc tcccaccaca gcctcccaag tagctagtgt aagccaccat gcctggctaa
|
60301tttttgtatc tttagtagag acgggatttc gctatgctgc ccaggctggt ctcaaactcc
|
60361tgagttcaag tgatccaccc gccttggcct cccaaagtgc taggattaca ggcctgagcc
|
60421actgtgcctg gagggtattt tttttttaaa aagaagaatg tagtatttaa aagttcatca
|
60481tgcaattaaa cctcattgat tttgagagca aaggagcaaa gaaaaatctg gcaaatagca
|
60541aacctactac ttaaagtaaa cctttaggaa cttaagcagg gctgctcacc aaataattct
|
60601gctgggtaca gaactgatgt ggcctttaaa ttacagagtt tatgtataat aattaacatc
|
60661caggccttgc agaaaacaat attacctctg cagagcatat cattttcttt attgataaat
|
60721gctctttact gaaaacacaa tgatatgagg atgggtagga gtgccttaga gctctccttg
|
60781aacatgtata cacagtggtt aagaggagat tctttgatga tggacaaaaa ttcaagtcta
|
60841gtttgattgt tttagcaaca ttacaggtaa gcaaacaagg caggaatgca aattaccaaa
|
60901agagttatgc ttcctagaga ttccccaatt ttgtagcctc tacttatctc gaggcaaagc
|
60961tgtctgacag agattctgtc ttctgacata ctcctattct tttctctttt ttattcttcc
|
61021tcttagtata aaatttggta aattttagtt aacagaacat ctcacaagtt cccaccctga
|
61081cttctttgct tatttcatag aaggaatSct aaaaaagaaa aatatatatt tttttctccc
|
61141acagtttatg gattacatcc tatgcagatg acacgttgga taatctcttt ttttccagga
|
61201tgaaacatat taagaaaata aaatacactc tcacaaatgc ccactacctc aagataaata
|
61261ggtagatctc acaatatctc agatatcacc taggagagaa gaaataaaat caagtatttg
|
61321gaagaacctg acagaatacc ttagccatac ctcagccttt cagagagcaa caggcatgaa
|
61381atgttttaga aaaataattt ctgttccctt cccccttttc ataaagtatt ctctctcagt
|
61441gatccattca aaagattaat agcactcatg gtctaaagtg ttcaagataa aacatgaaaa
|
61501caaaaaccaa agcatggatt ctactagaca acaaaacatg tctctcctaa gaatgaacaa
|
61561ttcaaccatt ccagcttttc acacctgaga atcttggatt cagtggattc tgaatatccc
|
61621aatgaattaa aattaagatg aacctttctc ttcaggaata gaacttgcta aaattagaga
|
61681taaatgagtt acatattttc agtgaaatac atattcctat tataagtcat atagggagtg
|
61741aggctcctaa aagcaggtgg ctaactctat ctacaacaaa cattttgaca agctcccacc
|
61801aacataatac atggcatcaa aacaatccga aggcaattca aacgatagct tcacgttaag
|
61861cagctgaggc actgggcaag caaaatctaa tgaagctata ttttctctgg aaggcaatta
|
61921gtaaactgct catattttgc tgctgaaaga atacatcagc atgaacagat ggaaatttag
|
61981aactccacaa atggaattac agacattgat ttaactttcc ccaagcaaat gaaaaccaca
|
62041aaatacgaat tgctctttct ataattaagc acataattag agtgcatcag attcatatcc
|
62101attgtagctc atatttcttc ctcctcattt ctaaatttat atatattctg agtctaacaa
|
62161acctacttag agttcaactc cacactgaaa gagtcttcta tgacagatag atggtactaa
|
62221actatttctc aaattaagcc tgccatgggt cacactagct ttttcacagc atgacacatg
|
62281cggcaataat aagaaatcca aagactcaaa gaggtagtcc ttgtggcagg acagatggag
|
62341agaacagctg agggaggaat tcagccagtt tattaactcc atgtgagtag aacaaatcat
|
62401atttaaaaga attcataagg acatctggtc gaaaaacaga atttaaatga tggcagtttt
|
62461agaatggaga aaagagaatc atgatgtctc acagtacaat atcactgagt tacctctttg
|
62521tttttctact tccaggaaac aaaaggtcac cagtgacctg cacacagatt atagaccaaa
|
62581ctggtgRtgg gcacttggga aatacttgga ctaattgtca agtttaaaat atacaagaaa
|
62641tactaaaaca tattatggaa ataaaatcac taacatgcta aacattacag atacttgaaa
|
62701ttattcacat tgttaattat tcttttcctc attctaggat acagtagttt gtcttacttg
|
62761tgaaaatatt taggggaact tagataaaat ttttgtttga tattcctaaa atgctagaaa
|
62821tgacctcaga aatctttttg agaataagcc ctttataaaa acctccaaat aggtctttcc
|
62881tgagaaaact caattgatgt gctttatcaa gtataatagt atgtttcatt tataagcttt
|
62941ccaagttgaa atccaaagta ataagcatgt ttcaaaaaaa atctaaacaa gtaaaaatgg
|
63001ggaaacttac taaaactgtg cacacatata tagcatcaag aaataaacta gcagtaaaat
|
63061ccaaggtcat attcagtgtg ataggcactg cagatctttt ctattaataa aaagcaacag
|
63121aggctttttc taYccatgaa atgttttttt aaaagagctt tcttattatt ttagtgaaat
|
63181gaagtttttc cttcttaata aaaattttca aatttctacc aaaaaaaatc cttaagtaac
|
63241tcaagttttg cagtttatgc ttatttaaat atttgatagg tattttctgc cacttgagag
|
63301ttgctattaa attttatata ataaacttca cttgcaaact gacttccttc tcagacaaat
|
63361caaatgacag caaacaaaaa taatgcctat taactatttt aagtacatta ctgtaccctg
|
63421tggggaaaat caggaaacaa aaactgtagt ttcagaattt cagatggatt agttattcag
|
63481aaattgtctt gaggacatgc cctaaccttt tgatatcact catcaaagga aaatgtgact
|
63541cacaaagact ttaatcccct ttcctcccaa cgggagatac agtctgtata gagagctgtt
|
63601tgcatttata actcaYttaa atcatgtctt ccagatactt caggtttaac tcacagtgct
|
63661acactcaaac taaccaattt aataaaagga ttataaaata tttgaagcaa acttatgcat
|
63721attttattca atggtttatc tccaaacagt agatatctac tgatgaacta tttgaacatt
|
63781agatgcatca aattcatatt cattgtagct catatttttc cttatcattc ctaaattcat
|
63841atatactgag tctaacaaag tacattgctt ctagttataa tcaaatatat ttataagtct
|
63901attcttcacc atgttgtttc aggaatttat tatggattca agagaattca gtaaaagaca
|
63961actggttaag ccacagttaa taaag4taga aacaatgcaa acaagaactc attcatggag
|
64021tagatttaat agagcaagta acacaggata ttcataatca aatgatatta gcttttacag
|
64081taaaaatgta tttgagagaa ttaaaagtca gtgataataa ggaatgagaa taactccttc
|
64141ccatcatcct cagtcatgtg aactatgctc aaaggcttca gatggtcaat aaattaatac
|
64201atgaatcttt aaaatataaa ttaaatattt ttatttagtt gctatagtaa atagaaagat
|
64261ttaatttata gtttaaagat tgtatacttt tatgtttagt atagcaactt taggattctt
|
64321tggttttcag taataatcta tgcatttggg taaccaaact tagtcagctt ggtcaggact
|
64381tttttgttta tttattttat tttattttat tttattttat ttattttttt taagacggtc
|
64441tcactctgtc tcccaggctg gagtgcagtg gtgcgatctc ggctcactgc aacttctgtc
|
64501tcccgggttc aagcgattct cctgcctcag ccttcccagt acctggcact acaggtggct
|
64561aatttttgta tttttagtag agatggggtt ttgccgtgtt ggccaggccc aaactcctga
|
64621tatcaagtga tccacccgcc ttggcatccc aaagtgctgg gattacaggt gtgagccact
|
64681gtgcccagca ggacattatt ttatattcag tcaaataata gtttaaaaat catagctaaa
|
64741agtggataag cataacttgt taattatgat tcaaagcagt tgatgcacat ctggttgaag
|
64801attagcagat tctcactgca gtttagttat aactgattaa catttcaagg gacataggat
|
64861ttcagattct acagtcagga aaccatacac caaacaagtt aaataatcaa gtaaggtaga
|
64921taattcatat ttggaggagt ttattttgtt tcttcaggag atgataagtt atcaaagatt
|
64981ctcattcaat agaaattgct attaactatt agaaacctac caagaacaat aaaagcaggg
|
65041acctgttttt ttttcatttt ttgtttaaaa attcaatgct gaatcactat catctaggtc
|
65101agtgtggaac acaaagtgtg ggttcagtca atatttatag aataagtgaa taaatactaa
|
65161actgttaaca aatagtcaaa gcttatgtga ataactctgt tggataaaaa agagaaaagg
|
65221gtaagaagtg aagaagagat aaaaaaggaa gaaataaaaa agaggtgagt gagaggaaag
|
65281tgaaaagttc tttcctagtg aaagaggtct ttcctatggc agcagaagag tagatttaca
|
65341gcaacctaaa agaaaacaga tggctgaatc ctttcaYtcc ccttacgtac atgtggtcca
|
65401acattgtctc aacaagactg tagccctaca accaacaatc gMaagagtga catcaacaca
|
65461taaaaggaag gaagtgcaca ttcagtggaa accccaatga gaaatacgct tctgccaaga
|
65521ctatcaggtt ggtatagtac ttgcgatKtc ttggcaagaa atcatgaaat acttgaagaa
|
65581attaaataat tattaggggg atgcttactt cactttacta ggggaggtcc ttgagtacct
|
65641cttctaacat ctaaagtctt ctcctctcca gaggaattgt gctccgttcc ctggttactt
|
65701ctcctttact tagggatttc agaattgtga ataaggaaag aatgacctgg taagtgccag
|
65761ccctggacac atttgcccac agatgctgtc ctcccccttt ctttagttgc tctttttctc
|
65821agggggctgg actctattag gccatatttc ccagatttgt ctgtcagttg ccttaggKtt
|
65881ggtctcagcc aataggaggg agatatcacc aggagacaga ggggagaatc taggccattt
|
65941ctccccaccc ttttctctag aagcagctgt atcttacctg tgttagtgac tctagctccc
|
66001attggacagg ccattactac ctgggctcca gtaaatcgcc ccctagctct caggttggta
|
66061gtggcttccc atttttgctt atctctgtgt tggtccaaga gtgtctgctt ttgacttctg
|
66121cattgcaata tgagaacatc cttatctctg acacctttaa atacccctta gggtctcatc
|
66181tacttagatc tctgatctta gaccacatgt ctctcctgac tRcccagctg gtcttgactg
|
66241cttggcctac atatctgcat cagctgtctc tctggaatgc ccagatcaag ctctggaacc
|
66301tgttctactt tgaccacagg cttctgattc ccttctctct ttcttctgat cccRtctagc
|
66361tctattccat tcacttcatc atggttgctg gtcctatagc tgctcaaagt tgaaaagttg
|
66421ctactctgaa tgctgatgtt tgctgaactg caggacaaaa ccactctata attatctcta
|
66481agttcccact tcagatttac cttgaataga ttttaggcat aataggcata cacaatatca
|
66541aagtttacat atttgtgtca caagaagatt aaaaataaag tatatttccc acatgattgg
|
66601tcatcccttc catgcatcct ctttggtaat atccagtaag atataatggc agacaagaag
|
66661atggataaaa taatgtcaga tagtaactct gctcacaggg catggaatct atgatggcct
|
66721tgtaataaaa tagcttaata tagccaggtt aacttgtttc tataaattct ttcaccgtag
|
66781gcaaaaataa cataatccct aaagtagtga actagtaaat aataataatt aagcatttaa
|
66841gaccctctta atcactttac attataaaca aacagtaaat gtgtaatagt gttgactatt
|
66901ctgggctcat gtttcttaag tgtttatttt aattgaactt cagcactaat acatgtaact
|
66961gttactctgt ttcccaggtt atactctccc tgggaatctg aagatcatgt tgtttaattc
|
67021aggatctgta tcggtagatt aaattcccac ccaaccctgt cccaattccc aaattaatct
|
67081tgagttaggt gaaaaaataa caagcaagct cagcactggc cctgtttacc aaatcacctt
|
67141ccagccaaat tggttgaatt agttacacct tttctcttag tctagtggag gatgtcgtgt
|
67201gtccttagat tcccaaacaa aacWtgcccg ctctctctct gtggtctaca ttatagctgg
|
67261agtacaattt ccaggcctca tttccagcat tctcttctgg aactttcatt tggctgccac
|
67321acagaaggcc ctatgtttcc tgccagctgt cctctgggtt ctcaagtacc ccaggttcac
|
67381ctactagaga aaagaattcc aaaatgccag ctgcccaagc agctctacct gcctctctgc
|
67441cctgattccc agagtaaggt ttcagccatt aagaactgtc tctgggcatc tctgaaacac
|
67501agccttcaac acaatggtct atctggttga tcaccactgg ccatgaagct tggcctcaac
|
67561gcctgtccca tcttagggga tggttctaat ctcaggtcta gctccttcct tttagtcaag
|
67621aattgaggaa tcatgaagtg ttctctgact ccatatgttt gtactaggct tcttcatgat
|
67681gatttatttg agttttgatg tacttggttt tggctgaact cacatctccc tctcctgctc
|
67741cctctcccta tgcccttgca aggaacaaga actacaaaat ggagcctttt gtaaggccgt
|
67801tgcactcagg agctttcttg aagtgctctg aaatttctgg cagaaataaa gctatttaaa
|
67861aaaaatagtt acagcttatg ttcctcttct tctgtgccct gagaaatagt taatcaactc
|
67921ttccttagct tggagttcac ccagatgctc cttaaggctt atctgtagct ccactctcag
|
67981tggtaaagcc accactggat cctagcaggg tgcctaaact cagtaatgtg gtaagagata
|
68041aggcaacaaa gcttcatgaa cattgtattt tcttccaaca gggcacaagg aagatattaa
|
68101actgagttcc ccccaaaatc ccaaaaatct cctactgata atcaagattt gtggaatcta
|
68161taatgtgtct ttattttggt ttaaactaat gacactaKat tttcttctac ctggcaaaga
|
68221agaggtaggt atacattaaa caaaagaaaa tgaaaaaaat ggacctaaaa tcatgtggga
|
68281aatagatcat tgtcatcatt gttcaaaaaa gaaatgttgt ggaatatttc tgcaatttcc
|
68341tggccagcta gtctttttca ccagacgcat atatcttttt caaatatcaa aagatagtaa
|
68401agctatgcat gtaaaagtca taatagtaat agtaattata agtattataa gggtaagaat
|
68461aatttacatg attcttactg actcccaagc atttgctaag cactttaact tttcaaaatc
|
68521tcagaatgct atgctgtaca tatgataaga aaggagaact ttcttagttt agaaaactga
|
68581gttgcagaaa ggttaagcaa cttgatcaaa gcaaattagt aatgggaaga gcagaaattt
|
68641aaacctaact catctttcat acctatgaag atgcaaataa gtcaaccaat tacatttgtg
|
68701tgtaatatat ttgccctctt gatgaataYt gaaccagagt tagagcatct tctatttgtt
|
68761tcatgaaaaa gcattgacat tatacacgat ttgtgtgttc tactttgaaa tcacactttg
|
68821ttactctaaa cattatttga ataagaagtt gctaataatt tgagcagtta tttcaaaata
|
68881tttatgtact attactacac agatggatta ctcttgagct tggcatccaa tttttaaaat
|
68941tttctaactc atgtgtacat gactaatttt ccctctcaga attatgacaa cattcattca
|
69001tatgctcttc tctcttgatt tttgtacttt ggtagtttgg gaaacatgat aagatagMtc
|
69061gtagtataac taatagctta gcacacatag catatctata ctcttttgac ttttcctcta
|
69121aatatcacct tatcatagtt tgttctttat cccctatcca cttgccatta tttccatcca
|
69181atgaaactta tttttcttct ctctcatctt tgaatttcct tccctcccta acagcatgtg
|
69241agttacttga aagctctttg atcagaataa aaatcccaat tatttgatac ttccatttat
|
69301ttggattata aagacatacg ggggtatatt ttgcaaaaca gtcttgtcag ccccggcaga
|
69361agatatatca ctatattata gctttgccat gtgtccatag agaaaggtta tcttatgtta
|
69421aacacatgtt catatgcaat aacagagaca tgaattctaa ggatattgca gaaagcatag
|
69481ctgactactg attctagcac cttcaggatc tttctcttct tagttgYgac cactgtaatg
|
69541cacttcatag agtaataaat tgttcttgcc ctgggatcat gattcccatc tcttcactac
|
69601aacatgtcta gatgtaagac atgtttaccc ttgtataatc aatgatctga gtctagatgt
|
69661caagtacttg cttgttctgt gcattaactg tcttcttttt ctggaactgc aggctctatc
|
69721agatccttcc cctaaaattc atacatcctg ccttgttact atccgtgccc cagcatgacc
|
69781aatatcaaag tggttaagaa aaaggctcca gctattttag tatcctaaat tttatctttt
|
69841cattctacaa agaagttttt cataaaaagt taaaataaat ttaaaaactc attgatacta
|
69901ttcagtaaga tgttatagat tccaagcaac tatctctttt ataggcaaca taattaaaag
|
69961tgaattacaa ttgcagactt tatgactcta attaaactct aggccacaat gcattaaaaa
|
70021cagattatac atattaagtt agatataaga aaaaataaat atgccacata gtgaggcata
|
70081agttaatatg cctcaaaata aatgaggaga aacaatttca gataatacat atttatataa
|
70141aatgtttatc aacataacct aaaatatttt cttgaatttc atcagagata aaatttttat
|
70201acttaatttt tgtaaacata tacatcatac tttctctcac ttacttcact acttcattcc
|
70261atcccaagaa catctgtgca agtatttccc aagtgtggga gactggaaga ggttctatat
|
70321tttggttgta agaatatata ttaattttta gaacattata attaaactca gaaatattta
|
70381attgtaggga tattatttgg taagaatcaa ataaaatgac taaaaattaa cttgaggcaa
|
70441catgaaatct caacatcatt gtaaaactaa gagagcagat cttaaacaaa atgtagtgca
|
70501gtcttcacac ttgggagatt cattaatcac ttaagtgttt tctctgaagt ttttaaatgc
|
70561ttaaagattg ggttacatta tgaaaaggac ctgtttaata ttgtgtctgt aaagttcaat
|
70621tctacctagt tctcactttc tttcgtatct tctctagtga agaatgaaga aatgagaatt
|
70681atgtgtttga atctagcacc tctgacatgg aaaaacacat ggtgaagcag aggaaagaaa
|
70741actgaaagaa agtgaaaata tctttaagaa tacYttgggg aaacaaacag tatttcaaat
|
70801gaaagattaa gaacaaatcc aaacaaatgg attggaaggt attatgtaaa aaaatatgag
|
70861atgctttagc acaggtactc taagaatttg agaagcttct catgtttaag ggagaaggta
|
70921acattcctga tagaaacatt taaaggcagt gcagaaagga aattctcatc aggaggccta
|
70981tagaacacac atgggcaaca gcaagccccc cttgccctgc tcagccctgg atccatacag
|
71041aggaaaggag agaggtaaag atgaaagaaa gaggttgaac agaagatagt aaatggttga
|
71101aaaatatttt taaaatagaa agagttatgc ttctgagaag attctccatg tctgggtatc
|
71161agacatggag atacatcata ctgatcaacc tgaagtaatg tacttactga aatacccact
|
71221tctagttcat cWagttcatg caaggtttca caaagccacc aatcgtttta atcatcttat
|
71281aaaagctttc taattgaaat attcttaagt atcacatttt actagtggca ggtatctttt
|
71341caaaaaaaaa atacaagcta agcaacttgt cctctgttgt ttcctaccac taagtttgca
|
71401ttagaagaga ctggcagtca aacacacaag aagaaacaca agtattggca atttaacaga
|
71461aacaaatggt agtgtatcat ggacatctaa ggtttgtagg actaaatcat accctcttct
|
71521agtaagtcct gaaaaaaatg tatttaaaac atatgttgaa gaaaatagct tttagagggg
|
71581cagataatag gctttggact tagaaatttt ataaaaatcc attgtgcatt ctttaggctt
|
71641ctagtcctat tcagtttttg ctatgagcta tgatttgttt gtggaagcaa agtaaaggca
|
71701gcctatttct taccgcctcc acttcggctg ggtcatacca gacgttgatg tagggatgct
|
71761gtaaggcgtc gtccactgat attctttttg ctgggtcaat cactagcatc tttgacaaca
|
71821agtccctggc ttggctggct gaaacaataa atgagaaaaa caattagtaa gattttgatt
|
71881tcagtaagga aatttgtcag agaggaaatt taagaaaaca aagtatggaa tagtatcttc
|
71941ctKccaaaca tcaggtaaat cccttgatgt gatggaaaag aaaatgcatt ttacacctgt
|
72001ttctttgtgt ctctaagcct aaggcttcat tctgaggctc tccaagggtt gtaacacttt
|
72061gggtatataa ttattcacgc aaacttctta gtaaaatgta tcaacctgga gagtttatgt
|
72121aagcaaagtc atcttctttg gtaacctgca tgaatatagg ataaacagaa taaagagcac
|
72181agagtgcaaa tgcatgatgt tcaacaaatg tgtggacggc tgtttgaagt taatcaacac
|
72241gtgtgtctct atattcttat ttatacaacg gaattatcag aattttagta tataaattga
|
72301cttaagagtt tgtatcatac aaatttttct tttctttttg tttttgttta tttatttatt
|
72361tatttatttt tgagacaggg tatccctctg ttgccaggct ggagtgtagt ggaatgatca
|
72421cagctcactg cagcctggaa ctcctgcgct caaaggatcc tcccatccca gcttcccgag
|
72481taactggaac tacaggcatg caccaccatg cctggctatt ttttctttct ttcttttttt
|
72541ttgtaaagat aagatctccc tacattgccc aagctggtct cgaactctgg gctcaaagat
|
72601cctcccacct cagcctccca aaatgctggg attaaaggag tgagccactg ctcccagcca
|
72661caaatttctt atatacataa aaacaatcaa agaattgaag tgatagaaat aatatcattc
|
72721aactactgaa ttttatttta acattctgta atcatcaggt atttttaatc aatggaatca
|
72781tgacttgatg aaatccagta gttaaagact gaagccagtc taatgctaca ccagacacta
|
72841atgagaaact ctatattatg taaaggttat cataattaat tttatggttg tgggcagtaa
|
72901cagttataaa attatatggt gatagctatt tatttagtaa gattgttaaa agacacatta
|
72961attttaacct ctaaaaatat gtaaattttt taaattatta tactttaagt tctgggatac
|
73021atgtgcacaa catgcaggtt tgttacatag gtatacacat gccatagtgg tttgctgcac
|
73081ccaccaacct gtcatctaca ttaggtattt ctcctaaagc tatccctccc ctagtctttt
|
73141acataaagtt ttaacagaaa tgaatatctc aaatcaatat tgttactcaa ctgatctgaa
|
73201agttgaaccg tgaaaatatt cagtttattc taactatatg gtaaaacatc aaattaaaga
|
73261taacaaaatt taaatggatt tttcaaaaaa tcaacataga tgactctgga tacatatcaa
|
73321tttttattta atcaattttt cagattaaaa caacttggct aattctacaa atttgaaaat
|
73381tatataaaat acaaaaWtca ggaaataata tctaacccca ctagctagag gcaatgactg
|
73441tgattattgg catatttttt ctagtgccgt tcatgtattt ttcacgtaat attaaccata
|
73501ctatagttaa aatgtagcaa ttaatttttt acctgtaagt attttcttgg taattacatc
|
73561aataaatata tcttttaatt ttctgaacaa atatgaaaaa tcactagtta aacttgagaa
|
73621ttttttattt ctattaatca tttttctggg aaactcaatc ctagaaactg attatcatta
|
73681ctttcaaatt aaaactctgt accgcacagg aataacaaaa atacagaaat acttatacat
|
73741taattcaata tttaattttt ctcattgcca atggcctcct aatagcctaa cagggctgtg
|
73801tttatttatt cattgcttta aagacctctt taatttgtaa ctgattttac atccaaattc
|
73861atgtaccatt ctcataagat tctctcatca aatctatcca tttttctgct cttagaaagg
|
73921gctggggtta gccgggcgtg gtcgtggctg acacctgcaa tcccagcact ttggaaggcc
|
73981gaggcaggca gaccacgaag tcaggaggtc gagacgatcc tggctaccac ggtgaaaccc
|
74041catctctact aaaaatacaa aaattagctg ggcgtggtgg cgggcgcctg tagtcccagc
|
74101tactcgggag gttgaggcag gagaatggag tgaacctggg agacggagct tgcagtgagc
|
74161ctagatcggt atcccgggcg acagagcgag actctgtctc aaaaaaaaaa aaaaaaaaaa
|
74221aaagaaaggg ctggggttac aatggattct tcatgaatag ggtcatgaac tacaccaata
|
74281caaaatcatc ttgctaagaa acaatactat ttttaggaaa caatatggga aaatgtttca
|
74341atgctttatc tttcattctt tcatttgaaa gcaaatgtgt tatgctcttt tccaaacaca
|
74401gtagaataca ttcttctctt tggttatttg tatattaaga ttatttataa tttgccaatt
|
74461ttatattaaa aattaaattc aataatcaaa tatgcaaact agtttatcat ttacaaacat
|
74521aattgcagag attcaaattg atttaaaaag taaactcaag aaaattggaa ttacattatg
|
74581aagtataata tatatctatt ttttgagacg gagtcttgct cactctatct ctaggctgga
|
74641atgcagttgc ccgatctcgg ctcactgcaa cctcttcctc ctaggttcaa gcgactctcc
|
74701tgcctcagcc tcctgagtag ctgggactag aggtgtgtgc caccatgccc agctaatttt
|
74761tttatatttt taggagagac gcagtttcac catgttggcc aggatggtct gtctcgattt
|
74821cctgacctct tgatcctccc gcctccgcct tccaaagtgc tgaggttaca gacttgagcc
|
74881accgcccccg gccctgaata tccagacaat tctaaaatcc gtggctactc ccctttgtag
|
74941gaacgatctt tgaagaaata tttctttaac ttgaggctgt gccaattaaa gaattgatca
|
75001atgttttagg tgatgggtta tgctaattgc tctgatttga ccattatacc tctatacatg
|
75061tttcaaaaat accaccctat atcccacaaa aatgtacgat tatcatgtgt caactaaaaa
|
75121taaaagggaa caaagagaaa gagatagagg tctctatact gtgtgcttgt ttggcccgtc
|
75181accctcatag ttgtcctcaa gtcattcctg aagggcatac ctttgagttt attgtgctcg
|
75241gagtccgctg ggaagaggga atctgggaag agtttgggga aggtgagtcc cgcatacttg
|
75301ggccgattct ccacatagtt tcttactgtg ggttgcaatt tcttcatgaa ttctggacat
|
75361ggtgttccta gttgttcaat taccttattc cactggtcaa tatctgagaa ttgaacagtt
|
75421aagggaaaaa agaagagcag accactagcc tttcaacaat tgggagacta actcttctca
|
75481aagtcctcaa cagtcattaa tgcaactgta gttttaataa gcaacaaaga atgaaaatat
|
75541aaaatcagac ttgcaggcta tgagtcttct tgaaatttta aattcacttt tgaaacttat
|
75601atacttttgg aaaactagca attatttaac aaaataagat atcatgaaat agtctttggg
|
75661gtgtacagat aaaaagtcat tcagataaca caagatgaat ctcatattct gcagataaac
|
75721ttctatataa atcatgtgat tcagaagaaa aatatataat gacacatcat agtgacattt
|
75781ttatcctgaa gttacctcaa ttatttatat ttttaaaatg acaaatacac aaatatttta
|
75841gattatattc atttacattt tcctaaacta tctttaagat attttttctt ctctaaaaat
|
75901ctggaatttt tttctatttt tatgcatatc aacataactt ttatagtaaa acaactcatt
|
75961agttctttgt cagattccta aaaatcatat ttattaaaca aagaagccac ctatttcata
|
76021cctattgttt tactgatgat atcactgaat attgttttca atgaaatata agggtgaaca
|
76081gaggaatatt caatttaaaa caacagattt ctatccaagt acatccaagt ttagaaagta
|
76141cattaagcat ggggaatacc acagaaaaaa tattacctct ctatgaaaat taataccctt
|
76201ttaaattgga gctagctctt tttgcagaca tactcaatga ttgagattct cttttttatc
|
76261tgtcattaat attcgatata tcagagcctt gataatgata aacaccatct actctgaaga
|
76321aYcaactgga aacaactgat ttaaacagat ttcctcgcca tgtgccagtg aataatagag
|
76381atcttggaaa ttcccttaaa tccaatactg caagcagtat tctctcctac attgcttatt
|
76441cttctacaac tgttctttgg tgttaagtta gttaactcat ttccactaag gtaaggtgtg
|
76501acagttaagg gactcttacc ataatattac ttagttgaag tttgtcaagt ctttactcct
|
76561agctattcaa gaggtttgga ctgaaaaaga ttgtcagtcc tgattaaaga taaacttaac
|
76621tgtattcaac aaaaagaaat atataataca aacagtagat aggagattga acaaagataa
|
76681aatcaaacta atttgcaaat ccttttcttc atctctataa tctggctgaa taaaacttaa
|
76741attattacat attctgtcag ttattggaat aaaaaatata taaccatgga ctatgaagat
|
76801atgaaatgaa ggtgggaaaa acaataatat tccttaataa agcagtagta ataattaaac
|
76861aagaacatgc tttgatagaa gctcatctaa ttatcatgtg catgagaaaa tacagcagta
|
76921attcagaatc actagaaata atgaaactaa aacattatat aaggttagag ttacaaatta
|
76981ctcttagaca tgagcctgta ttaatactat ggatataggt aagctataag tacttagaca
|
77041tacttaaata gaatacatta gtgtagttaa ataaaaccta agtgcttgtc attataaatt
|
77101atgaagagac attttttaaa cagttaggtt agcatgccct accaagctat catttcatca
|
77161ttgatcaaac ttcctcaaaa ttctaaccac tcgatgtcaa acttaaaata gaggcaaaga
|
77221agatgtcaga ttttctgtaa ataagtcatt taacaaagtt ggcaaaataa tcccaacaca
|
77281gtattatatc ctaattacat ttgctataat tataaagata tacagtaaat aattgatttt
|
77341aaagaagtac tcccaaaaca aaaaaaactg atacttttat attaaagttt aaggagagtc
|
77401agatattctg gaatttgtta aataagaatt gttaaaatgt ttcttgtaat aaatcataat
|
77461tagaatctag agacacactc agcgctcttt cctaccttag gttgctttta aatgaaacac
|
77521tgttgtgatt cttgatgcaa tggtttacaa aaagaagggt ggcaaaaatc tttatcattg
|
77581tcaatgaaat agttaaatgt tcatactgca aatctgagtt acagtgatct ttaaaagtct
|
77641gtgtctttat tttaaccaat ccatttcaag atttttcttc ccaaaaacat atgtgtgtgt
|
77701atatctacat atggtaagta cttgttttct agatgttcat agaatacaaa catgaacaac
|
77761tatgtccaat ttagttgagc acatgatttt tctttctttt tttttttgta gcacttgaag
|
77821ggctttattt ttttttcttt ttcttttttt tattatactt taagttttag ggtacatgtg
|
77881cacattgtgc aggttagtta catatgtata catgtgccat gctggtgcgc tgcacccact
|
77941aactcgtcat ctagcattag gtatatctcc caatgctatc cttcccccct ccccccaccc
|
78001caccacagtc cccagagtgt catattcccc ttcctgtgtc catgtgatct cattgttcaa
|
78061ttcccaccta tgagtgagaa tatgcggtgt ttggtttttt gttcttgcaa tagtttactg
|
78121agaatgatga tttccagttt catccatgtc cctacaaagg acatgaactc atcatttttt
|
78181atggctgcat agtattccat ggtgtatatg tgccacattt tcttaatcca gtctatcatt
|
78241gttggacatt tgggttggtt ccaagtcttt gctattgtga ataatgccat aataaaaata
|
78301cgtgtgcatg tgtctttata gcagcatgat ttatagtcat ttgggtatat acccagtaat
|
78361gggatggctg ggtcaaatgg tatttctagt tctagatccc tgaggaatcg ccacactgac
|
78421ttccacaatg gttgaaccag tttacagtcc caccaacagt gtaaaagtgt tgctatttct
|
78481ccacatcctc tccagcacct gttgtttcct gactttttaa tgattgccat tctaactggt
|
78541gtgagatggt atctcatagt ggttttgatt tgcatttctc tgatggccag tgatgatgag
|
78601cattttttca tgtgtttttt ggctgcataa atgtcttctt ttgagaagtc tctgttgatg
|
78661accttcgccc actttttaat ggggttgttt gtttttttct tgtaaatttg tttgagttca
|
78721ttgtagattc tggatattag ccctttgtca gatgagtagg ttgcgaacat tttctcccat
|
78781tttgtaggtt gcctgttcac tctgatggta gtttcttttg ctgtgcagaa gctctttagt
|
78841ttaattagat cccatttgtc aattttgtct tttgttgccg ttgcttttgg tgttttggac
|
78901atgaagtcct tgcccatgcc tatgtcctga atggtaatgc ctaggttttc ttctagggtt
|
78961tttatggttt taggtctaac gtttaagtct ttaatccatc ttgaattgat ttttgtataa
|
79021ggtgtaagga agggatccag tttcagcttc ctacatatgg ctagccagtt ttcccagcac
|
79081catttattaa atagggaatc ctttccccat tgttgttttt ctcaggtttg tcaaagatca
|
79141gatagttgta ggtatgcggc gttatttctg agggctctgt tctgttccat tgatctatat
|
79201ctctgtttag gtaccagtac catgctgttt tggttactgt agccttgtag tatagtttga
|
79261agtcaggtag tgtgattcct ccagctttgt tcttttggct taggattgac ttggcaatgc
|
79321gggctctttt ttggttccat atgaacttta aagtagtttt ttccaattct gtgaagaaag
|
79381gcattggtag cttgatgggg atggcattga atctgtaaat taccttgggc agtatggcca
|
79441ttttcacgat attgattctt cctacccatg agcatggaat gttcttccat ttgtttgtat
|
79501cctcttttat ttccttgagc agtggtttgt agttctcctt gaagaggtcc ttcacatccc
|
79561ttgtaagttg gattcctagg tcttttattc tctttgaagc aattgtgaat gggagttcac
|
79621tcttgatttg gctctctgtt tgtctgttgt tggtgtataa gaatgcttgt gatttttgta
|
79681cattgatttt gtatcctgag actttgctga agttgcttat cagcttaagg atattttggg
|
79741ctgagacgat ggggttttct agatatacaa tcatgtcgtc tccaaacagg gacaatttga
|
79801cttcctctgt tcctaattga ataccgttta tttccttctc ctgtctaatt gccctggcca
|
79861gaacttccaa cactatgttg aataggagtg gtgagagagg gcatccctgt cttgtgccag
|
79921ttttcaaagg gaatgcttcc agtttttgcc cattcagtat gatattggct gtgggtttgt
|
79981catagatagc tcttattatt ttgaaatacg tcccatcaat acctaattta ttgagagttt
|
80041ttagcatgaa gggttgttga attttgtcaa aggcttttcc tgcatctatt gggataatca
|
80101tgtggttttt gtctttggct ctgtttatat gctggattac atttattgat ttgcgtatat
|
80161tgaaccagcc ttgcatccca gggatgaagc ccacttgatc atggtggata agctttttga
|
80221tgtgctgctg gattcggttt gccagtattt tattgaggat ttttgcatcg atgttcatcg
|
80281aggatattgg tctaaaattc tcttttttgg ttgtgtctct gcccggcttt ggtatcagaa
|
80341tgatgctggc ctcataaaat gagttaggga ggattccctc tttttctatt gattggaata
|
80401gtttcagaag gaatggtacc agttcctcct tgtacctctg gtagaattcg gctgtgaatc
|
80461catctggtcc ttgactcttt ttggttggta aactattgat tattgccaca atttcagctc
|
80521ctgttattgg tctattcaga gattcaactt cttcctggtt tagtcttggg agagtgtatg
|
80581tgtcgaggaa tttatccatt tcttctagat tttctagttt atttgcgtag aggtgtttgt
|
80641agtattctct gatggtagtt tgtatttctg tgggatcggt ggtgatatcc cctttatcat
|
80701tttttattgt gtctatttgg ttcttctctc tttttttctt tattagtctt gctagcggtc
|
80761tatcaatttt gttgatcctt tcaaaaaacc agctcctgga ttcactgatc ttttgaaggg
|
80821ttttttgtgt ctctatttcc ttcagttctg ctctgatttt tgttatttct tgccttctgc
|
80881tagcttttga atgtgtttgc tcttgctttt ctagttcttt taattgtgat gttagggtgt
|
80941caattttgga tctttcctgc tttctcttgt gggcatttag tgctataaat ttccctctac
|
81001acactgcttt gaatgcatcc cagagattct ggtatgttgt gtctttgttc tcgttggttt
|
81061caaagaacat ctttatttct gccttcattt cgttatgtac ccagtagtca ttcaggagca
|
81121ggttgttcag tttccatgta gttgagtggt tttgagtggg attcttaatc ctgagttcta
|
81181gtttgattgc actgtggtct gagagatagt ttgttataat ttctgttctt ttacatttgc
|
81241tgaggagagc tttacttcca actatgtggt caattttgga ataggtgtgg tgtggtgctg
|
81301aaaaaaatgt atattctgtt gatttggggt ggtgagttct gtagatgtct attaggtccg
|
81361cttggtgcag agctgagttc aattcctggg tatccttgtt gactttctgt ctcgttgatc
|
81421tgtctaatgt tgacagtggg gtgttaaagt ctcccattat taatgtgtgg gagtctaagt
|
81481ctctttgtag gtcactcagg acttgcttta tgaatctggg tgctcctgta ttgggtgcat
|
81541atatatttag gatagttagc tcttcttgtt gaattgatcc ctttaccatt atgtaatgac
|
81601cttctttgtc tcttttgatc tttgttggct taaagtctgt tttatcagag actaggattg
|
81661caacccctgc cttttttgtt ttccattggc ttggtagatc ttcctccatc cttttatttt
|
81721gagcctatgt gtgtctctgc acgtgagatg ggtttcctga atacagcaca ctgatggatc
|
81781ttgactcttt atccaatttg ccagtctgtg tcttttaatt ggagcattta gtccatttac
|
81841atttaaagtt aatattgtta tgtgtgaatt tgattctgtc atcatgatgt tagctggtga
|
81901ttttgctcgt tagttgatgc agtttcttcc tagtctcgat ggtctttaca ttttggcatg
|
81961attttgcagt ggctggtact ggttgttcct ttccatgttt agcgcttcct tcaggagctc
|
82021ttttagggca ggcctggtgg tgacaaaatc tgtcagcatt tgcttgtctg taaagtattt
|
82081tatttctcct tcacttatga agctcagttt ggcctgatat gaaattctgg gttgaaaatt
|
82141cttttcttta agaatgttga atattagccc ccactctctt ctggcttgta gggtttctgc
|
82201cgagagatcc gctgttagtc tgatgggctt ccctttgagg gtaacccgac ctttctctct
|
82261ggctgccctt aacatttttt ccttcatttc aactttggtg aatctgacaa ttatgtgtct
|
82321tggagttgct cttctcgagg agtatctttg tggcgttctc tgtatttcct gaatctgaac
|
82381gttggcctgc cttgctagat tggggaagtt ctcctggata atatcctgca gagtgttttc
|
82441caacttggtt ccattctcct catcactttc aggtacacca atcagaccta gatttggtct
|
82501tttcatatag tcccatattt cttggaggct ttgctcattt ctttttattc ttttttctct
|
82561aaacttccct tctcgcttca tttcattcat ttcatcttcc atcactgata ccctttcttc
|
82621cagttgatcg catcggctcc tgaggcttct gcattcctca catagttctc gagccttggt
|
82681tttcagctcc atcagctcct ttaagcactt ctctgtattg gttattctag ttatacattc
|
82741ttctaaattt ttttcaaagt ttttaacttc tttgcctttg gtttgaatgt cctcccgtag
|
82801ctcagagtaa tttgatcatc tgaagccttc ttctctcagc tcgtcaaagt cattctccat
|
82861ccagctttgt tctgttgctg gtgaggaact gtgttccttt ggaggaggag agatgctctg
|
82921cgttttagag tttccagttt ttctgttctg ttttttcccc atctttgtgg ttttatctac
|
82981ttttggtctt tgatgatagt gatgtacaga tgggttttca gtgtggatgt cctttctgtt
|
83041tgttagtttt ccttctaaca gacaggaccc tcagctgcag gtctgttgga ataccctgct
|
83101gtgtgaggtg gcagtgtgcc cctgctgggg gatgcctccc agttagactt ctcgggggtc
|
83161aggggtcagg gacccacttg aggaggcagt ctgcccattc tcagatctcc agctgcgtgc
|
83221tgggagaacc actgctctct tcaaagctgt cagacagggg catttaagtc tgcagaggtt
|
83281actgctgtct ttttgtttgt ctgtgccctg cccccagagg tggggcctac agtggcaggc
|
83341aggcctcctt gagctgtggt gggctccacc cagttcgagt ttccaggctg ctttgtttac
|
83401ctaagcaagc ctgggcaatg gcgggcgccc ctcccccagc cctcctgggg ccttgcagtt
|
83461tgatctcaga ctgctgtgct agcaatcagc gagattccgt gggcgtagga ccctccgagc
|
83521caggtgtggg atatagtctc gtggtgcgct gctttttaag ccggtctgaa aagtgcaata
|
83581ttcgggtggg agtgacccga ttttccaggt gcgtctgtca cccgtttctt tgactcggaa
|
83641agggaactcc ctgacccctt gtgcttccca ggtgaggcaa tgcctcgccc tgcttcggct
|
83701cgcgcacggt gcgcgcaccc actggcctgc gcccactgtc tggcactccc tagtgagatg
|
83761cacccggtac ctcagatgga aatgcagaaa tcacccatct tctgcgtcgc tcacgctggg
|
83821agctgtagac cggagctgtt cctattcagc catcttggct cctccccatg atttttcttt
|
83881ataataacaa ttaacctaac ataaacgaag actggaactc ctatctcctg tttccatgtt
|
83941cagtgcttgt ttcaagtatt ccagtaagaa aaagtaaatt tggaattgat atggtaaaaa
|
84001attgttttaa tttggccata aagttaatgg tgtgttttgt cacaagcaac tcccttaaag
|
84061aatgtttctg aagccccttc cttagtctat caggccaaca tattcctgta aaacaattaa
|
84121ttttatcaat attttatata gaaaataagg tgatttttaa atgggaaaac agatttccac
|
84181aaggattaca tttttaaagt acataaaata ttaactagat tttatgatta tgtattaatt
|
84241gttaacatgg taaatatgtt tttaaagaat gaccaaaacc attttttgta gaagaattta
|
84301tttgctttag aatacccata aattaccatt tttataccac atagagtaag gatttacaga
|
84361tcttagccct gtgaggttat cagaaaagca ataagtatat tttttatatt tttgatgtgc
|
84421tgtttcagaa attatcaccc ttaacataaa ttatgaaatg cattgaatac aaatggaaaa
|
84481atggcattta ataagaatta tttgacagta aatcacctga tataattcta aattgactac
|
84541ataaaagtag agttatattg taagaagttc aattttataa gtagggcatg atgtccagat
|
84601aatgtacaaa tgtgatatta ctaaggtatt caataaatag tattataata gaataaaaca
|
84661aagtaaatat gaatagtaaa aatgagtatc tgaaatccta agattgaaaa tttttccaat
|
84721taatattatc aattagctaa taacttatat ttcaagcact tctcttactt tagcttcctt
|
84781tgttagggaa ctttctaaaa cgataatgcc ttgaacataa tatatgaaaa gggcaatttt
|
84841tgggcctctc atttgcacag gccccttata agactaatcc ttttctgcgt attgtgggtc
|
84901aaaattatga acagaattta tgccatccat atttaagcct tcagaactta ctaagtggaa
|
84961tcataaggaa ctatttaatg gcctcatcca attgtttcct ttgaatgact atatcttctg
|
85021tttatgtttt cttctatcat tgattgcttt ttgttactat gaatgtgatt tccagagcca
|
85081acacctcata gtttctgact tgctttgtac tctgctctag gccttatatc caatactttg
|
85141tgcaaaaatt ttctgacctc tctttgcaat ttaaagaaca tcagtgttta tctctaaatt
|
85201attagctatg ttcttaaaga caatattgcc taatagcaat gtcgttatag aatagttcca
|
85261ggagaggctt ttatcatgca cgccaaacag ctgtttaggc acaatgttga gtaggcttgt
|
85321gtggctttat attagcttcg taggaaagaa ttttgtgatc agttagtaat gtctgcaaca
|
85381gatgcacaat aaggaaattg aagcacatat gccatgtgtt aagcatcatt atattaaact
|
85441gtggttccca aacttgaata ttcgtaacgc agggaactta caaaaataca tatccctcct
|
85501ccctactcat tgatctacaa gattctgagt ccacaggtct gggctgatat cataaaaaac
|
85561accagtggta attgtaatca aggatgggat tatattttga gaaatactaa tgtagaatat
|
85621actaaaaagt ctcttgtgag ttactaagtc caaatgtaag agtaaaatac taacatgttt
|
85681cagttttatg acacaaatta gaataggatc aaattcacca aaagattatt ccacacctgt
|
85741ttgttaactt gggggtcatt cacctgagaa tactcagaga aagaaaagtg ctcatcttta
|
85801tttctttgcc ccatgtaatt ttcctgcaaa ggccatggga aattacagta agtggcacat
|
85861gcagtctcct agtagaggga gaagaattct gcccctcatc atctgtggga gaactgaaat
|
85921tgtatgctgc tattacctgg ggagtagtac ccatggaaag tactaattat agttctttgt
|
85981gattaaattt gttgttaaaa gaattttttt ctaaaaacaa gtataaggaa atacatatgt
|
86041atatatatat atacacacac acacacacac acacacaaac atatgataga gttctgaatc
|
86101tagattttca tggttatgtt tctaattgtt ttgtttcttt aaaaatgttt ttaggggcca
|
86161gggacagagg ctcatgcatg taatcctagc actttgggag gccaaggcgg gaggatcacc
|
86221tgagcctggg agttcaagac cagcctgacc aacatagaga aaccccgtct ctactaaaaa
|
86281tacaaaagca gctgggtgtg gtggcacatg cctgtaatcc cagctactca ggaggctgag
|
86341gcaagagaat cacctgaacc catgaggcac aggttgcagt aagcagaggt agcaccattg
|
86401cactccagcc tgggcaacga gagtgaaact ttgtccccca cccccccaaa aaaagaaaaa
|
86461gaaaaatgtt tttagggtat tttttatttg aaaatgttct tttcctctca aaagtccttg
|
86521tcagattctg gtaacaggaa atatgaataa gtgacttaat aaacaattgt aactaacatc
|
86581tgttttaatt ataaatgagc ataggaagag gaattataag ccaaaacaca tccaaaatat
|
86641gaagctggca aattaagtaa aaggctattt gtacactgac actagcacat tgctagtgtt
|
86701ataataaggg acatggaata tccaaaggct gtttgaagca tgctataaat ctattcacta
|
86761ttataatcta tctttactta caaataaaaa aatggagaga catgtaacat atatattaat
|
86821atgtgtagca atggcagaat tttcattaag ctgttgaagg ttaatctttg gggtgttcca
|
86881tttgcacagg cctcttacaa gactaatttt ttactggtaa ttttattttt tgtaaatagc
|
86941acccaccttc agttgtatga tattctgacc tcaaaaatgc tggatttgat tctctcagcc
|
87001tgtgatagta ttttgaaaat gagaagaggc cttggagatc atgtaatttg gcatctctat
|
87061tttaaagctg aaaaatatta aagtcctttt caatttggta aataattata aacaaagaag
|
87121ctgatacaaa cagcctacac gaacagaaat atagaatcta cttaagagaa atttaaggac
|
87181actgtactct gttctgtaag accaaatcgg gaaagatact ttcacttctg tatataacac
|
87241tacatacaat ggaagttaag aagaggcaat caagcttata tgaggtaaga aaacctgcca
|
87301cttaaagcat agctgaaaaa acttttgata tttaaattta aaaaggaaga tagaagtaat
|
87361ccctgccccc atgctagcat tttggtcttt tggtctctct tactctgcag ctattatcac
|
87421cttcttctag tattctgcac cttttaatgt aagtatcatg gtaataagaa tttttatctg
|
87481ttttgtttac taatatatct ctggagacaa aaagtaccca gtacatagta ggtactcaaa
|
87541aatatttatg ttataaatga atgtctattt tatgtccaga gttttgtaca cacataatat
|
87601aaagaatgaa aaaaataaaa tattcgaaga aacgacagct gagaaattcc agtaattgaa
|
87661taaaggttgg aatctaggaa acaatgactc tcaaggaaga taaataaaaa gaaatccatg
|
87721cctagtctcg tagtagagaa acagcagata atcaaagacc aaaaaaaaaa atcccaaatg
|
87781aaggaaaaga gcagattatc tcctaaaatg actattacac tgacaactct ttatttacca
|
87841gcaatactgt aaacaaaaag caagtagaat aatatcttta agatgccaaa aataaaataa
|
87901atttcaatgt aaaattctat atctaactaa actatatttc aggtaaggga acctcaatta
|
87961aaaataagag ttttattatc aaggactcca ctaaagatac ttccaaaata cgtacttcgg
|
88021gagaaaaaaa taataatctc aaaataaaag gtcaaaatgt aagaagtagt ggtaagccaa
|
88081acaaatggca atcataaggg tgaatctaaa caaactacct ttatgcaaaa aaatcataat
|
88141attgtcaatt tatgagccta aaaagaaaac taaaatactg aacatcgata gcatatttaa
|
88201gtcaggacaa caactatcta aatgaacatg tgccaagatc cttttatgtt gagaagaaag
|
88261attaaaagaa tcatcttaat taaaatagca ttgtatacaa aattgagctt taaatacgac
|
88321tccaaaataa ataccaatag ggatcttttt ttaaagttag taagccaatL ctaaaatctt
|
88381aatagaagag caatggtgca ttaagagtca agataattct gaagatgaca aaaatgaaag
|
88441gtatttacct tacctaatat aagtgcagag catacattta tattcattaa gaaagggtgt
|
88501tcatggtgca gagatagaca aacaaaccag tggaacagaa tatacagccc aggacttaac
|
88561atccccctgc aaatatgtgg aaacttatta gagagacaga attatagatc tgtgaagaaa
|
88621gagtaagtta gtcaataaat gaaactggaa taaagtaggt ccttctttca cacatacaca
|
88681aaaaaatcaa ttccatgtgg actaatggtt taaatgtaag agactaaact ttaaaatatt
|
88741tccagtaaag ttatagcaca atataatgtt ataaaaggat tcttaagaca taaaacatat
|
88801aaattatagg aaaagacaga ttgccaactt ctaaaactat tataaaataa aatgggaaaa
|
88861taatccaaat acaagaagat atttgcaaca cataaaactc acaaaaatta ggtgccaaat
|
88921tatataagga atgtctacta atcaacagaa aaaaaaagca caatagaaaa aaatgtgttc
|
88981attctttgtt tataaaaaag atattttacc aagggaaaat aatagtggcc aatgaacaca
|
89041ggaaaagatc cttagcctcc cttgtagaca aggaaatgta aattaaacct ccagtgaaat
|
89101agtattttat atccaaggga ttggtaacaa atttaaaaat aaatatgaca atggcaaaag
|
89161ttgatgagga tgtggagcag acagctacat actactctag aaatcaattt gatgttacac
|
89221agcaaagttt aaaatgtgta tgcctatgac ccctggcatt gttattaaga aaaccttgca
|
89281catgtgctct tataagcata tatttatagt accatggttt ataaaagaaa aaaaaaaaca
|
89341gtaaaatccg tatatattcc aaagtctact tataggataa tgggttagtt atagatactc
|
89401atagactgaa atactattca gcaatgaaaa tgagttaact atgtccagtc catgaacagg
|
89461aataaatcta aaaaatataa tgttaatttt ttaaaaagtg agtcacaaga taacgatgac
|
89521agtatggtat gtaaaataaa taaaactaaa ccatagattg cttaaggata aatatgcagg
|
89581tagtaaaaac ataaggaaag tcacagagat agtaaaaaga aatatttaga actgtggcta
|
89641actctgtgtg gaaaaggaag gttgtggtag gtggagcaca taaaaatatt tgaaagtatt
|
89701ggtaatggtc tattttttaa cctgagtggt agcatatgtg tgtctattta ttaatcttct
|
89761tcaaaagcta tgcatttcat attaactcac ttgtttaata taaaatattt tataatttct
|
89821taagtaaaaa tgtcagctat gataaaattc attacatctc cccctccttc caaattatcc
|
89881caacagttaa atgttgattc atttgtagag cattaaaaac acatttgatt gaataaaatt
|
89941caattaacat atatgtagga gttcagtcag ggtggcggga aaagttgtaa gaaaaagtta
|
90001tagggaaaga ctcaaacctt cttggaaggc caggaggttt tgcaaaagct tcgaaggaga
|
90061aatggctgaa ggcagccaaa ttctgttatc cagaacctga aggcaaaggg tagataacaa
|
90121gggaatgtaa aggaacttat ctagataagt tggtttactt atgtctctag aaaccaacct
|
90181ttgatcattc ctgcacagga ctgctctcta ctcagggggt tggcaaagtt aattacccac
|
90241aaattgtgtt tgctccaatc ctttgtcatt aaatctgtac taaataaatg caagtgtcac
|
90301aggcttatgg gggctgcact ctgggttgca ctgcactttc attggcagtg ctaaggggtg
|
90361cagtccatct agccatgctg tcaggcaaaa tacctgtgtc agagtacttt tgtcatccat
|
90421cactcagcca gagtctgcgg gacagacttg gcacatatac ttaaaatacc tactaaaaac
|
90481aatgtgttaa acctttttag gcccaaaaga taaaagatat aatatctttt taacatttta
|
90541agttttgttc ttgagttagt tcatatatta agaagacgtg tctggggagg cagagcagga
|
90601tggcaaaata gaaggctcca ccaatcatcc cccctgaaag gaccccaatt taacaactac
|
90661ctacaccaaa aagcaccttc ataaggacca aaaatcagat gaccactcac agtatctggt
|
90721tttaattcca cattgctgaa agaagcactg aagaggcagg agaaactgtc tttaattgcc
|
90781agcgccaccc cttccccatc ctccagcaac aattccgtgt gctggggaga gggagagcat
|
90841agcatttgtg aggaaatgaa ctcagtgctg cccttgttat agcagaaagt aaaaacaaac
|
90901caaattcagc tgacacctgc ccacggaagg agcatttaaa ccagccctgg ccagagggga
|
90961atcgccaatc ccagcagtca gaacttgaga tcccacaagc cttaccactg caggctaaac
|
91021tgctctgagg ctgagaataa acttgaaagg caggtcactg cctttctagg tcactaggac
|
91081tgcaactcct aggaaagtcc tagtcctgaa ctgggcccag agtcaatgga cttttggggc
|
91141atgtgaccta ctgagatacc agccagggca gctaaggggg tgctggcatc acccctcctc
|
91201tacccccatg gtgcatagct catggctcca aaagagacct cttccatcca catgaggaga
|
91261ggaaaggaaa gagtgaaaag aactttgtct tgcattttgg atatcagctc aaccacagta
|
91321ggctagggca ccagtcagag ttgtgaggcc tcccttccag gccccagttc ccagatgata
|
91381tttctagaca caccctggga cagaagggaa cccatggcct taaacagaaa gacccagtca
|
91441tatcaggatt catcacctgc taactgaaga gtccttggtc cctgaataac cagcagcata
|
91501cccaggtact atgctgaggg ccttgggtga aactctgaga cttgctggcc tcaggtgaga
|
91561ctcagcacat tcccagttgt ggtgactatg gggcgagaca aaaaagcaga gggaaagtaa
|
91621aggggacttt gtcttgtacc ttaggtacca gcttggccac agtgtgggta gagtgccaag
|
91681caggctcttg agttaccaat ttcaagattt ggctcttgga ccgcctttct gggccactca
|
91741acttggaaaa gaagaagtca agtaactctt gtttgcagat gatatgatgt tatgcttgca
|
91801aaagcaaaga ctccatcaaa aaactattca aattgataaa ttcagtaaag ttgcaggatt
|
91861caaaatcaac atacaaaaat cagtagcatt tctatatgac agcagtgaac aatctgaaga
|
91921agaaatcaaa agtgtaatcc catttataat atctacaaat aaaataaaat acctaagaag
|
91981taacttaagc aaacaagtga aagatctcta caataaaaac tataaaacac tgataaaaaa
|
92041attgaatagg aaacaaaaaa ttgaaagata ttacatattc attgattgga aaaaccaata
|
92101ttgttaaaat gtccatacta cccaaagcaa tctacagatt caatgcagtc cctatcaaaa
|
92161tacgaatggt gttcttcaca gatagaaaac acaatcctga agtttatatg gaaccacaaa
|
92221agacccagaa cagccaaagc tatcctaagc aaaaagaaca aaattggagg aaatcacatt
|
92281acctgacttc aaattatact acagaactat agtaaccaaa cagcatgata ctggcataaa
|
92341aacagacaca tagatcaata gaacagaaga tagaacccag aaacaaatcc acacacctac
|
92401agtgaactca ttttcaacaa aggtgccaag aacatacact ggggaaaaga cagtcccttc
|
92461aataaatggt gtggaaaaac tggatatcca catgcagaag aataaaacta gatccctatc
|
92521tctcaccata tacaaagatc caatcaagat gaattaaaga cataaatata aggcttcaaa
|
92581ttatcaatct tctttaagaa atcactgggg aaattttcta ggacagtggt cagggcaaaa
|
92641atttattgag taatacctcc caaacacaag caaccaaagt aaaaatggac aaatgggatc
|
92701atatcaagct aaaaacttct gcacagcaaa gaaaacaatc aacaaagtga agagacaacc
|
92761tacagaatga gagaaaatat ttgcaaacta ctcatctgac aaggaattaa taaccagaat
|
92821atataaggag ctcaaacaac tctataggaa aaaaatctaa taatccgatt aaaaatgggc
|
92881aaaagattta aatagacatc tctcagaaga agatatgcaa ataacaaaca ggcatatgaa
|
92941aaagtgctca acatcactga tcatcagaga aatgcaaatc aaaactacaa tgagatatca
|
93001tctcaccccg gttaaaagag cttatatcca aaaacaggca acaacaaatg ctggtgaaga
|
93061tgtggagaaa agggaacact tgcacattcc tggaagtgta aattatcata ataactagga
|
93121gaacagttct gtggttcctc aaaaaactaa aaatagagct accatatgat ctggcaatcc
|
93181cactgctggg tatataaaca aaagaaagga aatcagtata tcgaagagat atctgcactg
|
93241ccgtgtttgt tgcagcactg ttgacgatag ccaagatttg gaagcaacct aagcatccat
|
93301caacagatga atggataaag aaaatgtggt acatttaaaa atgttaagtg aaataagcga
|
93361ggcacagaaa gacaaacact gcatgttctc atttacaagt gggagatgaa caatgagaac
|
93421acatggacac agggagggga ataatacaca ctggggcctg tcaggggagc tgggtgggtg
|
93481gagggagagc attaggaaaa ctagctaatg catgctgggc ttaataccta ggtaatgggt
|
93541ggataggtgc agcaaaccac cacggtacac gtttacctgt gtaacaaacc tgcatatcct
|
93601gcacatgtac cctggaactt aaaattaaaa ttaatttaaa aaatcaaaac aattgaactc
|
93661atcgagatag acagtagaag gatggttacc agaggctgga aaggatagca gaggaggtgg
|
93721tgggtgggga tggttaacgg ctaaaataaa aagttagaaa gaattaataa gatctagtat
|
93781ttggtagcac aacagggtga ctacagtaaa taataattta attgtacatt ttaaaataac
|
93841taaaagagta taattgaatt gtttgtaaca caaaggataa atacttgagg gagtggatat
|
93901tccatcttcc atgatgtgat tattatgcat tgcatgcctg tatcaaaaca tctcatgtgc
|
93961cccataaata tacacagcta ttatgtaccc agaaaaatta aaaattaaaa aaagtcatgc
|
94021atagctcata ttccaagagc ttttagaaat cattgttttg agaatgcttt tatataaatg
|
94081aggatatatt gactaaaaat aacataactc cttataatgt actatatagg tatacattat
|
94141aatatggcat atctccagct ctattttaat gtctctattt aatagattta ggtataattt
|
94201tattgtattt tcagtaactc atttctaata acagaatttt ttaaatcagt aatgtcttat
|
94261acattaagag gttaattatt tgatattcag tgttcaaaat ttgtttgctt taagactgat
|
94321ttaaaacttt aaccaacatg tttgaaatca ttgagaccac agcccacgat cagaagacat
|
94381actttagaaa atgattccta tttgtcctcc aagaaattta caaatatgtc cccatacaag
|
94441agctccataa aggacttcat atccaaatat caagggcttt gaacaggata ctgccacatt
|
94501acccgagccc taaagcattg tttacaagga attttgacac ccaagttaaa aaatgacaca
|
94561cgagcaactt ttcccaagaa actattctaa aaaatgttaa attgtatttg gtaattcagt
|
94621tgtagaaatc tgttttaatt tttcttaata gaaacataac aaagatcata aaaacactca
|
94681ttttaattta caggtggcaa atattcattt tagtcaccaa ttattcaacc acaatgaact
|
94741tctggaaaag caaagagtac taagttaaca aattgagtct attttcatca aattatctaa
|
94801aatcagccaa aacttaaaga caatttcata ttcatgccca aaggccaaac acaagtttat
|
94861aattcattgg gaataaaaga agtcctgttt tttaaaatcc ctcctgattt ttaagaaatc
|
94921tgaaggaatt cagtttttat aaagccagct agtttcaaat agcattaatg ttgatgtggt
|
94981aaattataga cgtcatttaa taaaatgtat atttagaaga caaaacagca ctatagacag
|
95041aaagactttt taaaatgtgt gtcaaacaga agattagaaa aaagttttta gtaagaataa
|
95101tcagaagtaa aaacagtgta actattttta actgaagtat tttaagtcct ttcttccaac
|
95161aaaaattgag tgcctaatac agccatttcc agaacttttt cttttaatat gtagagagaa
|
95221tatatgtatg aagccatata tatatattca tatatgtaaa accagataca aatattaatc
|
95281ctcaagtgtg tatattacat tatagacatt tgataaaaaa ttataatgta gatattagaa
|
95341acaacgcaaa tggctaatca taatatggta tggatgcact atattagtaa ttagatttag
|
95401tctaattaca cattaaaacc ccattattat aggctcaatt ttatttttga agtgttttat
|
95461taaagcagag gttttacctt tagtaggatg aagacataaa actttcataa gtgactaagt
|
95521gtagagggat atttaacagg acccatgaca catccatata ctaatcacta atcgcacact
|
95581attcatatct atttaatact gcagaacctc tggaatcttt ttgtttgttt gtctgtttgt
|
95641ttagagacag ggtctcactc tgttgcctac ctaggctgca gtgcagcagc acgatcactg
|
95701ctcactgcag ctttgacact gggggctcaa gctatcctcc cagctagttt ctttgttgct
|
95761gagactacag ggactttcac cgtgcccggc taaatttttt atttttgttt tttgtagaga
|
95821caagggtctt gctctcttgc ctaggctggt ctcaaactcc tgggctcaag tgatccttcc
|
95881acttcagcct tccaaagtgt tgggggttac aggcatgagc taccacatct ggtcttgatc
|
95941tttacttgtt aattatttgc tgcttaagag agaatcactt ttacttattc aagtgatttc
|
96001aatgtatttc ttcagatatt ttatataacc attattaatg aggttttaat tattgcactt
|
96061gttaataata tgcagaaaat aagagaagga attagagcta ttattcccat aaatggagtg
|
96121aataagaaaa ataattttag aaaaacttga tcaattgtaa aatgaaattc acatccatgc
|
96181tctctgaata tatgttaaaa taaaccaatt agtatttgtg gaggaacatg aatctgataa
|
96241aaatttccat gccaaatgaa tatttctcat tatatcaaag tataaatctt cagtcttaga
|
96301actgaaagac tttatttatt atctagctat gaatatatct tcattttgaa acatctacaa
|
96361caaaaacaag aaagaagagt actcaatgtt atcagtttgg tagaactgaa ttaaggcaga
|
96421ccttttgata tcaggttgac tctttcatat ttgttactgt attatccaca taaggtctta
|
96481ctaggagaca aagttactct gccataatgc caacttgtaa atatttgaca ttgagtctca
|
96541tagaaactct ctaaggacag tgaacaaata ccataagcag tactgcattt gagacaaaag
|
96601ggaattaatt gagagtgaca cccatagata ccactggctg ctaagaagga tacgatcagt
|
96661gccaggaaac agcactgcac cttttatcat ttctcccatg atgcacccta ctgaccacat
|
96721gtcaactgaa aacaaaaatg aaatgaagat aaacaagaac acaggaatag aacaacaaat
|
96781aaatgaaaac actgggctac tcatgccata gagcaatagt ctgacttttc actgactgga
|
96841tgagaggcca gtggcatgat cattagcatt ttaaatggtg gaaaggggag aacataggct
|
96901ctcaaggccc ttttctgtca tataacagaa ataacaacac tacccaatgc tacctaatgt
|
96961agaataatat tactttgcaa ttataactca atgattaatt taggttttga tttaaaaggt
|
97021ctaatttgca ttcatttact agaatcctac tgatttttat cataaattat tctagatagt
|
97081gttaatatgc aaatcagttt cttttttact cttgtatacg tatttgaaaa aagaaaaaag
|
97141aaaagctgag ctgccagcaa cctcaaaaga gtttctttta taaaacacat ttacccttat
|
97201ttataaatat aaatacagtt ccagaagtga aaagccagtt caagaatgaa tgtttcagaa
|
97261tatgttgtct tagtgtcatt gactctcatc aaaggagcat gtttctcagc aggaagcctt
|
97321gtcttattct tataaacaca gttgccttat aatgataaga aaagctggct ttcaaaatgg
|
97381gatcgctcaa tgtgaaataa acaacatgac taaagagctg atacttcttc tgaaactgtg
|
97441aatcaaaaga aacctggaat tcaaggtgga attataatgg tctctctgtt attgccaagt
|
97501atcatccaga acttaaaacc aggaagccag ggcagagcgc acagagggag gggcaaaatg
|
97561gggaagggtg aagcaagaaa gtgaaatctc tctcttgagc tacacttggt tactcacttg
|
97621ttgtacttaa aaatcagaaa gagagggcat tcttgtgggg ggaaaaataa acagaagaat
|
97681tagggatgct gggggggagc aaatagggaa aggcattaag atagcagcac aatataattt
|
97741tgctccactt acttttcaaa ttacatcttg taatttggca gtgaccttaa agagatcctc
|
97801atgagattca ttccaatgtg aaaatctcac tcgggttaaa ctcaaagttt ccattgtttg
|
97861atttaacacc taaacaaagt gatcactgca aagaaacggt tacggctttg aaggtgataa
|
97921gcatacccaa agaagcaaat ttgttttgct tccagtttag gaaagcaact gacatgcaga
|
97981aatatcaggg aaagatagag caaacagttg tgcatccctt tattattaac gtgtttgtaa
|
98041tttcaagtaa tatctgtctc acaacaggat ggtattgaga aatctttgat taaagaaaaa
|
98101aacggaaaac atatttattt ttaaattcca agtattccta tcatactgtc caaagagacc
|
98161agtttgacta aattgctatt tatggattat ctatatttta tagatattgt ggaagagata
|
98221tacaaaaaac attgagacca aaaatctcaa tatgcagtgt tttctcttgc ctgtctccat
|
98281tcaaatgttt agaaaaaaaa tggtttctgc cattaacctg tctgggactt aggaaacatc
|
98341tatttctatt tctcatttag tataaaattg ttttttacaa tatctctggc aatatattca
|
98401tctttttctg ctagagaacc aattctatta ctttccaact atgtgacctt ggccaggtta
|
98461cttctctcta aacctcaatt ttatccccta aaatattgat gataagctgt atttattatg
|
98521tagagtttta taaaagactt gaaaaagtta tgtctgataa agatccttgc acaactgcct
|
98581ggtacatagc aagtccccaa taaatattat ttacatatca aatcatcatg tattaaataa
|
98641tatattaaaa ttatatttgg gaattaaata tctttggaaa aggtttattt attttaaatt
|
98701tacataatta tattatatat ttacatctat aataaagaaa tctttccagt ggaggaatct
|
98761caccactcac taggcaatct attttattgt tgaaaccact tagaaaggca tcctacatat
|
98821tgactcacat tgactctatg gaacttctct tcactatgta aacaggaact actgtgtttc
|
98881ctcatccaaa taagaacctt aaagtatgta actataacct gtaatcccta accattcctc
|
98941tcctaaaact ggccaatttt atctttcagg ctaaaatccc ttgatttttt tttttttttt
|
99001tttttttttt tttgctgttc ttcacatgcc tttaaacaac agcaacaaca ataacaacag
|
99061atggcctaaa ttaaattctg gtctctatgt tgctttagca ccagttggtt ctatacagtt
|
99121gttaattttt ttttttcttt gagccagtgt ctagctctgt cactagactg gattgcagtg
|
99181gcacgatctt ggctcactgc aacctctgcc ccctgggttc aagtgattct cttgcatcag
|
99241cctccctagt agctgagatt acaggcacac gccaccacgc ccagctaatt tttgtatttt
|
99301tagtagaggt ggggtttcac catgttggcc aggatggtct tgatctcctg accttgtgat
|
99361ctgcccacct cggcctccca aagtgctggg attacaggca tgagacacca tgcctggccc
|
99421agttgttgat ttaataactg gtattaataa ctggtatatc tcacagttct ctttttggtg
|
99481tgggggatct gggagatact ccaatgtaaa agaagaatat ttatttaaaa tatatatctt
|
99541catgggcaga actcaaaata gatttaatag atcacaaatc ttttgcataa aaataatgca
|
99601gagatgtagg ctctagatct gaaattctga tgtacatatt gaatttcatt ttctttattt
|
99661taatatatct ttatgggtga taatatcctg gaaatctttc taattcccat tttaacttta
|
99721ctcaccattc actattccta gagaatattt atatctatgc taccaaaatg ctaagccttg
|
99781tgcctagaaa tgataagctc tgttatcttg aattacaaaa attgaatata tgcacataaa
|
99841tttatataga tttttatgta ttcaagacag gattatggct caagataaac tcattgtacc
|
99901aaacttcatg aatttgccat ctccactaac agaaaatgta taataaaaga atttgatacc
|
99961aactcttatt gaacaggaag gtagtagtag taagccttcc ctctactaat atctctatat
|
100021taggatacat aaacatacta atacaatatg tatctgaata tattagtgat atatatatat
|
100081atatattgct aatgaagtta agaatagatt attttatgaa attgtcaggt attacaatga
|
100141atagggactg tgcatagacc ttagaagtaa ttagcaaatt caatcactgt tggaaactgc
|
100201attttatgct ttctgaaaca atctgataca gcatctgggt ctctgtaaga gttctgtaca
|
100261ctaatgctgc caaggtagaa ttctgttggc ttttaaaatt ctgattcatc acattctttc
|
100321atcatcattc tatcattccc ataggcagaa ggcagattca cttgcaactg taacaatcag
|
100381atgctgagtc actttcctta gaagaaatgt tgagtaaatt ttggtgttac caaaatatga
|
100441ttaattttca gagtgagaac ctctgaaaat ctcatgtcac attatttgtc agaaattagc
|
100501ttataataaa ttatctttct tctacttcta accaagagat agaaattata caatgtaagc
|
100561cctggaagtt aaatctaaat aaataaagaa ctatattgct acttccacac tccatctaat
|
100621agcttaaatt atgatccaca attaaataat tttgagacta tgtgagcttc tatcctggaa
|
100681aatgtttcct ctctggggga ttacgtaact cttttatcac aatttctgag acttctcctt
|
100741aacacaccta agtatatttt catttagtgt agaatttaga caaattttct ctcaatgaat
|
100801gactcaacac acaatagcaa gaagatttaa tatagttttc taaaatcaga acatttcttt
|
100861gaaaattatt tgttataatt tttataaaaa ttataagtta taaagttagc agttataaaa
|
100921ttagaacatt tcttttaaaa ttagttaact aagtcataaa tttagttgtt taacaaaagg
|
100981accttgtact aaacttcagt tcaaagacag aattctaaaa gaccactgat atacataaat
|
101041aaactaagaa tgtacatatt ttgcacatgt gaatctaagt aagaaaaata agcaacaatt
|
101101cgcagaactt aatgctaaat attgtaatgc caggaaatca gaaaaagact ttctccttga
|
101161atctacctat taaacttgct tttatttctt tacaacctca gaatctccag ctcccattct
|
101221ggtgaaccct gcctcacatt ttcataaaat aataacaaaa gagaagagtt agcaggcaca
|
101281ctagtggtaa aaatgtattc ttttaaacaa attcaaataa taattttatt tttaaatatt
|
101341tatttataat tacatgcaat ttgcttatag atttgaaaga atgcctacta aattgtttca
|
101401tcctaacttt atttaaaacc ataaatttta tattgtttga aataactctg tattgtctta
|
101461attctaagaa aaagagttag actatatagt aagttgttag ttgcaaaagt ttattaggaa
|
101521ttaagcacta ttatttcaaa gaggtaagaa gaattttaaa atatctctgt gctagattga
|
101581tataacaatc tgtaaccaca aatttttgtt cattttactt tgatccttcc taatgttcat
|
101641attcaaactt taaaaagata cagcattcag ttaatttgag ggtgtttttc ttatttcttc
|
101701aaatatactt ttggaaaacc atttacctat tccttaataa cttggctcct tggcaaggtt
|
101761atatgtatat ctctttcatt ctaactgcaa tttcctgttc ttcagaggga aaggcaagag
|
101821gagctatttt agcagtccag ctgttagctt tggatataat atacttgagg tccagaattt
|
101881tcaaatgcat gcagtatgcc tgtctttaac tttatatcca gagaatattg gccaagaact
|
101941tagataaagg gacatcacag ggtttgctca aagaaggtgc tatcatttga agtagaatgg
|
102001aaaaaataag gttgaagaat gtatctaaaa gaagcaggtt tgaggaaagg actcatgaaa
|
102061attatactgg gactatagga gtctttgata atcaacaaga tggcatgtcc tggttggggt
|
102121ttggggtggt ggaggcagtg aatgactgga tagttcttag aaaaaacttc taaggaagca
|
102181ttgtaaagct gctttcctgt aaattttatt gaaaggaaca aaatctgagt gaagctaaag
|
102241tcactgattt cttttatctg ttctttggac tacataaaaa aaaataatgg acttggccta
|
102301tttactactc tctaacttga aagtcagcat gcgtttaaga atgtttaaag aatgtttagt
|
102361aacatattta aatatgaatg tgcattataa tgttcaaata aactacatta tgtaaaaata
|
102421tatgctatga aatgttttaa tcataaaact atagtgaaaa ttaagtgtat gatagtgtat
|
102481gcataattaa gaaacacttt acacaagaaa aataagtatt aagaagtgat cctctggata
|
102541ttaaagtaat tagcaaatta ataagtggaa aagcaaatat gtattgttta ttttgttcaa
|
102601ttttattttg ccaacattct aattcagtaa ccaagacaat tccctgtgat atcatctaga
|
102661tcatatcaac caccaagaaa cccccacgat gtttctcaaa atgcaaagat agtttgaatg
|
102721tgggaaagta gttaaacttc agtcatcaat gacaatttca taagattctc tgatttgtca
|
102781agacatttta ctatttttgc ttagggttca agtttaaaag ttctgtgaag agagaagaaa
|
102841aatgttgatt attatgatag tattatcaca tcatttttca gcctcaaagt aatttaatat
|
102901aaattactct gaataattct aggtgaaaga catgagaacc tctgattgtt ttttgaaatt
|
102961tctgcagagt cctggaagta gtcaaggtat caattagcat atacttagct ttgatatttc
|
103021ttccaataaa tgttagacta atttcaatat gcttaaaatt gtgtaattct tctgccgata
|
103081aataacttga atcagccctc agccttgtgt ctgatagtca tagtttgaga ggttatctga
|
103141ctgctcagtt gttggtagga agtcctgtgc ataaaatgat aataatttca tttaaagatt
|
103201aataaaacaa ttctactcaa aattaacaaa gcacattgtt taactgagat ttctataggt
|
103261ttatttttta aatgtaacta taactttaaa cattaagtta taattttaat tataggtaaa
|
103321aggggctaag aaatccaaat ggaaacattt tcaaaaagga aacatttttt ctaacctatt
|
103381tcattggaaa atatctactc attttttggt aaaatttaac ttaagtaaaa ggctttccat
|
103441tgtaggtgtc tttatgcaat tttttttaac ttttaggtcc acatgcaggg tcattatcac
|
103501atatggcact aggctatcaa agactgctgt actatgtaat catcacttga gataaagaaa
|
103561tatatatatt tatataataa atgcaaacct ttattataat ctacattatc tgtattagag
|
103621attatttaaa tgtctaggtt catacatatc aaggatataa atgttatgta ttaattttca
|
103681cacaatttaa tttcagctcc aaaaattttt ctaaaacaaa ctaggattaa aaaaggtggg
|
103741aggggcacct ccaagagaaa aatttttaaa agaaaataaa attatcaata tggtgctttg
|
103801tttttttgtt tgtttttctg aagggttaga ttgagtttaa aactttttgc tttttttctc
|
103861ttttattggc ttttaaattt aatattgtca aaatagaaga aaagcaatcc gcataaatgc
|
103921ctgaagagct aaataagatc tcagagaaca acctcgctac atgaaatcaa gtgacatgta
|
103981acaaaatgtc acatggaaat gagaaatcct gtggcttttt gctttccact gacaagtgca
|
104041tgagagagat gtggctgtgc aacttcactc tgagtattga ttgagaggtt ccttttttgt
|
104101ctaaaatgtg ttatatacca aaggcaaaag cataaagaaa ataattccta cttttgaata
|
104161aagtcagcac atttaaatat gaatgtgcac tataatattg ttcaaataaa ctatattagg
|
104221tatataatta atccccaaac tatagataag taaagtgaaa taaattttcc taagtagcca
|
104281tatgaaatct aatggtgaaa atgatacttc acactataga taggaaagga acatggagca
|
104341aacagagatt caagacctta agattggtta taaataaatg gttgccatgt ggttttctta
|
104401tcttctagac cagcactgtc caatagaaaa atgacagtca caaatgccaa tcatatacgt
|
104461agttttaagt ttaatgtcca cattcaaaag aataaaaaaa gatatatata tttaacccaa
|
104521tatattcata atgctatcac cttaacacaa gctatataag attattagta atatatttta
|
104581catgctttta aaaatatctt caaaatctgg tatgcatttt acacataaaa cacatttcaa
|
104641tttagactat aatttcaagt gctgaataac cacatgtggc tagtggctac ctactagaca
|
104701gtgcagttct agaatatgtc atcactctta cattactagt ggattttaga gactatctca
|
104761ttaatatcca gcagaatgaa tacataccta cctaaataca agcttattat ggtacccact
|
104821tcttgttgag tcaggttttt ttgtttttgt tttttactat tggacttttt aaacacctca
|
104881ataaaaatca taacctttct tacataatag aaggattcct taataaaact ttcttatcaa
|
104941tcaaatagaa tggttaatag agttatgggt cacatggtta ttgccaattt ccaaaacatc
|
105001catatgtaat aaatatacta aattcaatcc tgtattataa ttgttaaagt tgtcaatggt
|
105061gattgtactt agatttgcac tagtatttgt agtaaggtat ttttgtattt ttaaaagtat
|
105121attatactat tatatgtaaa ctttattgtc tatatattac aaacacaaat ctgtaccttt
|
105181actagagagt gaatttttgg ccatttaaga aatgtatcag ttcatttgat aattccaaat
|
105241catagatagc tctacaagaa atttctgatg gactctattg caggactcag tagtagaact
|
105301taaatccaaa ttgctttatg aaattataaa tttagttggg aaaacaagca tgtatgtcta
|
105361tgtcacatct ccaagtcagg tgagagaagt ctacattaaa ctcacctgac cactagcaac
|
105421ttgaacaata attacaattt ttaaatgcag aagttcatgt tttgaggaag atatgctata
|
105481ttgacctgtt aaagacttga tttagtgtcg agtaatttaa atcaacaaag ccatagacag
|
105541aagcttagaa tgtcagcaag gagagcaatt attatgccta aatattgtag aagcacaaaa
|
105601tagttttaga aaggagatgg aaaatgactt gcaaatagtg acttattttg ctagttataa
|
105661aggtaaatat attttaatca tttgggatct ggtagccttt gttattaaag aaaaatagca
|
105721tttctatttt tagttgcagg caagaaagta attttagaag aaaaaagccc attgaaattt
|
105781aattaaaaga aatcattgtg gtaggcagtc ttcagtactg gtcagattat agaaattatc
|
105841acttttttat tacaataaca ccacttaccc aactttttgc ttctatcttt actctcctgg
|
105901taaaatcatt atgtgtttaa aagggagaga gaacaaaaca ggtaaagctg tagcaaaagg
|
105961tacaaggata cagtcccttc ctggaaagag gattttgtgg cgaaccattt ctcccataat
|
106021gcatcccaca gaccatatat ccactagaac aggagagaga gggtagtgaa gaaaagggag
|
106081gaaagtaaag ttaactaaga taattgactt ctgaaggagg aggaaaaaga acagtttgat
|
106141taaaagtaca attttcacct cccaccaaaa gttggccaaa atgtgaattc aaaccagcgc
|
106201tatgctatta cataaacagt gtttagtatg agaactcaaa ttaatgttta aaaacccatt
|
106261actttgtggg tgccttacat tgcctctcag cagtgccaca aagtggtgac attggtgact
|
106321gagaaaagca atagctaaac caaaagtatc tccatggcag gtgacagcta aaagccacca
|
106381aagggttttc tgtgtcattt tccggatgca tagaaaacaa tattaacttg tagagttggc
|
106441tattttcatt ttctattcta ttcagttaca gagaataggg caacaagaga ccaccttttt
|
106501tttcaggggg ccagggggcc ggggcaaaac aagataaatt caaccaaatc caataaacca
|
106561ggaaatgact ggaaccatgg tttagaggca aaagaattgg aattcctggt atttgggact
|
106621tagcttttcc ttcagaagtt tattcttgta aataaacatc agttttagtt tccatttgaa
|
106681atatttcaag aaaaaagaca tatgatgaat tagcacatgt ataaaggagt catctggaag
|
106741gaaagtgaaa aaagtattaa aggtgttaaa aattgttatg tacatatatt tatttccaaa
|
106801ttgtcaaact tgttaggaaa acatgctttg ccttctctta ccaatcttta cccctttcca
|
106861acttgctttt cattatggac aaagggaact tttgggcaga atcatttggc cgaattgttc
|
106921catggggaag gaaggcgggg ctaggtgcag gggacagcag ggcatgcctg atgtgggagc
|
106981aagcaggttt ttctgcatga taaccttcct cccattggtg ggagggcagc accagggtgc
|
107041taggcaggcc tcctccatgg acttagagaa gtcaaaaacc taaggcagca acttgcaatt
|
107101ccttctagtg agggaaggga aagggatttt aataccagct attggtagtg ccaagatctg
|
107161aaagcccaaa taggcaaatt cagaccgccc caccccccag tctcctgtac attcttgatt
|
107221cttgactttg tttctccttt gactttttaa aaataactcg tgaagaaagt ataaaaatgt
|
107281cttcttttct gaataaatta gatgtggtat tgcctagcaa ggagggctag attcatctct
|
107341tctgagtcaa aaggtaccag aactccgata ttgcccacca gggtgaacct gacctttgta
|
107401agaggtgact ttttaacttc ctctgtataa atgcatacat acattatctg tcttctaatc
|
107461taagagtata caaagaagtt tctgtaaact tcagtggcca gggaattttc acaaaagtac
|
107521cctgtagcac ctgtacataa aaatacactg attattttta taaaacttat taatacagac
|
107581tgctaaaaac taaatagaat agaatataaa aataaatatt aaagatacac tgaatacata
|
107641tacaatccta atttaaaact attttaattc ctaagtatat tgaatatgtt ttcaatatgg
|
107701tgcattactt gtaagatata gtctcatcaa aataatacat tgcaatgctt tctaacatat
|
107761ttaataaatc cttagtttta atcaactaca ctcaattgtg atacattttt aagattcctt
|
107821ccatagcctt cattttaaag tgttcatgaa cattaagttt tctttatgaa agcagtagtg
|
107881tcaaatttga cattttcctt ttttacgatt tttggaatat ataaggattt attaggcaat
|
107941tgctactcta aatgtttctt acagagcagc ttaaattatt acagaaattc ttattcagtt
|
108001taaataattt ggattatttc aaagttgtct atgaagattt tcactctaag gatttgtgtc
|
108061acttttttgc ttgtcttttt ctagaactac agccatcagt ctgagataca acataaaagc
|
108121cacatggcta actgtggtag attcctttct gctttcacac tcatgctcag ctgagctgca
|
108181acccaaatag caatttttct caatatctag gcacgtgtgc taatcagcat ccgcttgact
|
108241gtttaatcag actccattta caattctttt tcactattaa catttagtgc tcttctagca
|
108301aaactgactt ctcaataaca tccttcacat ttttaatgag tgtttcttac cagtagtatt
|
108361aaaaaaaacc ctgaatatgc tatctggcag ccctacttta taaaagcatg tacataaaag
|
108421agaacattcc ccttggctat ctacaacgtg cacccgtttc attcatggtt ttgatgctgc
|
108481tctcccgaag catccctacc gttctccttg tagcccatcc ccaggatgac ctcaggggct
|
108541ctgtaataac gtgtcaccac atatggagtc atcatgaagc ttgtgcctgc tgtcctggcc
|
108601agtccaaagt ccaggatttt caatgtgcaa tcagacttga ctacaatgtt acttggtttt
|
108661aaatcctaac agtaaggata agggaaaaaa ttaaaagcca gtatcaagtg aaatgttatt
|
108721tccattgact caatcaacat agccattttg cagtagcact gatgaggtcc cccttgccta
|
108781cagagctcta aataaggcaa atgattactg ctacaaataa gttaactatt agtttttgga
|
108841aagtgtttta atcccagaaa agaattgtat tatcattttc acaatttaca ctaatcttgg
|
108901gaagaggttt tagaaaaaaa aatatttatt gtcttctgtt aggtttctcc ttaggacaac
|
108961ataaatcttt caacatatat atcatttcta ggcctgacag aagaacagat cagggaagct
|
109021gtctttatgc tgccagaaac atctatggaa atgaattttc ttatttcagt tgcacatatg
|
109081acttctgcca atcaaggagc tgaaagcatg aggcttctaa gaagctgcat ctcaatgagc
|
109141caaaacataa cattgaacaa actcaactac aatataacta gaatttcctt ctacaattag
|
109201tgaactaggt gctaattcta gtatcaaaga aatgaggaag tatattatat ttgaccaatg
|
109261ccccccgtat aaagaaaata atctacagtt actcttcctc ttaaagcatt tgaattgtaa
|
109321tcctagagaa ggtgttctta ccctgtgaat aattccagca gaatggaggt gcttaatgcc
|
109381acacaacatt tggtacagca ggtaagacat tcgctcatgg tctaattcca tctgaatcac
|
109441ttgacataag ttggcatcca tcagttccat tactaagtaa ctagaagggt gaatccacag
|
109501tgttagttcc agatcacaag atctatgaag tcctttgatt tagtcagaat gctctcctaa
|
109561ctctgtaagt cttctgaact tcttagctct gcctttgact taatcaagac tgagcatttc
|
109621caggtattgc atgtgtgtta gctatacgaa ccctaccaaa aggttgctag tagaaaaagc
|
109681atttattaat gtctggttca tgtccacaga tttgttacct taattttgct ttcactttcc
|
109741cctgtattcc ctcaactctt ttgtgaatat tataatttca aataagaaaa aaattaagga
|
109801cagcttcttc cattaaattc aatgtatctg tattaaagac aaggtgctag ggaatcactt
|
109861cctctcctcc atctgttgtc actactgggt agactttgca caaaatcaat gacactataa
|
109921agatagaaag aataaagata attttcacgt cccttttatt actatttctt tttgtttgtt
|
109981tgttttgaga cggagtctcg ctccgtcacc caggctggag tgcagtggta cgatctcagc
|
110041tcactgcaac ctccgtctcc cgggttcaag caattctcct gcctcagcct cctgaatagc
|
110101tgggactaca ggtgcatgcc accacacctg gataattttt gtatttttag tagaggtggg
|
110161gtttcaccat gttggccagc atggtcttga tctcctgact ttgtgatcca cctgcctcgg
|
110221cctcccaaag tgctggaatt acaggtgtga gccaccatgc ctggccttat tactatttct
|
110281tcaggtaaat taactcattg tagaaagttt gtggaatcta ttaataaata taaataaata
|
110341agccttccct gagtgaccaa gagcatggaa caacaaagta tataaagcca caaggccaaa
|
110401aggaggcaga atgtctttcc aggaagtaac cccacaaaca gaatcttctt tacatatcac
|
110461tggacccctt tcatttgacc ccacctctta cctctctttg agcagtataa gggatttcaa
|
110521ctctgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtggtgtg tgattttccc
|
110581ttgggctatc tgagtgctgt gctctccctt ccttcatgag ttttgttact tacacatctt
|
110641ggaactcctc cagcgttttc tggggtgtga agacatttaa taaactaata atctgaaaga
|
110701gagYggaagg gacagaggaa acgagagaaa gaaaaaagag agagaatgta ttatttttaa
|
110761attgtatttc aactcaaagt cactcactag tgctatggca gaaatggaga agttggaaaa
|
110821atgtcttgag ctgtctcaga ggacacagaa aagtatgctc agaaagaaca gatgatctgt
|
110881cttcaggtta ataatgcagc taaaaagctc aattcttggg cagaagcaag agtcagagag
|
110941atgcataatt
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AA” (SEQ ID NO:).
|
AGCAAGGCAGATGATGGAACAACAAAGAGAATCACCACTGTAAAAGCCCC
|
CCAGTCCTTTGCCCACTAGGTCTGCTTTCCTATAATATGTCTAGGAGGTG
|
ATGATATTATCAAATTCACAGAATATAATATGTTCTGCATTCACTTGTCT
|
GTCTTAACACACACACACACACACACACACACACACACACACACACACAC
|
[A/C] CCAAATATTTCTTAAATAGTCACCTGTTATTTCCCAAGAACATC
|
CCAACTTTTCCGGTAGGCAAGTGTCAAGTCACCTGGACAATATTCCTCAA
|
AAAAAGTGAAGGTTCTACCTGGGGTTCGGGCTCATTTTGGAACATCAAGT
|
TGGCACTCTGAGGAGCCTAACCTTCTCTTAGGCTTCCTTTGGGGCAGTTG
|
GTTTCC
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AB” (SEQ ID NO:).
|
AACATAAAACAATTCCATTTAGAATAGCATCAAGAAATACATATTTAGGA
|
ATAAAGTTAGCAAAAGAAGTACAAGTTTTGTACTCTGAACTACGAAACAT
|
TGTTGAAAGAAATTAAAGAGGATCTAATAACTGGAAAAACATTTCATTGC
|
TCATGGATTAGAATATTTAATATTGTCAAGAAATGACAGATACTCCCC
|
[A/G] AATTGATGTACAGATTAAGCCAATACTTATCAAAATCATAGCTG
|
TCTTTTTTGCAGAAATTGACAAGCCCCATCTTAAAATTTGTGTGGAAATG
|
CAAAGGATACAGAATATCCAAAATAACCTTGAAAAACAACACAGCTGGGA
|
AATTTACATGTTCTGATTTCAAAACTTACTACAAAGCTACAATATTCAAG
|
ACAGAG
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AC” (SEQ ID NO:).
|
TTTGATGAGGCACATTTACCCTTTAGCCCATGTTAACATTTTCTTCAGGA
|
TTCATTACTATTAAAATTATTTATGAAAAAGTTTTTGTACTGGATCATTA
|
CCATCAGAATAATCAGAATGAATGCCACACTGAATATCAAAAGAAATAAA
|
ACTAAAATCATTATAAGGACACAACCATGTGATATTTGTCCATCTGCTCT
|
TTAAGCAATGTTATGTTATTTCTTGCAACCCCTACACAAAGGCCAAGAAA
|
TTACACAAGTACTAGTTTATTGGTTATTCACGGAGAGTGAGTACCTGAAG
|
GAGAAGGCTGTCCTTTTACTACACCATTTTTAGTCTTTTCTTCTGAATTC
|
ATTACTTCCTTGTAGATAAGTTCTGTAAGAAACAGCTGTGTTATTATAGA
|
AAACAAATTTATCCTTCATCCACAGGGAAATTCATTACTTAATGCCAATA
|
ATTACGTTTTGATGGGGTTGAGTAAATTAAAAATCA [A/G] TTGAGAT
|
TCCTTTACTGCTCTATTTCTATTTCTATATTGCCTTGTAATTAGCAGAGA
|
GCCTGGCACAAATAGGTATCTAGTAAAGCAGTTGAAGAAATCAATGCATG
|
AAAATTTATTTCTACGTACATGAAACATACTATTTATTTCCATATACATA
|
GTATTTATTTCTACATACATTTCTACATAAATAACATTTATTTCTACATG
|
CATGAAATATTTCTACATAAATGAAACAAGTAATACATGTTTTACTTGTT
|
TTCTGAATTCTTTGGGGGAAGTACTAATACATTCTAGCTCAATCTAGCAA
|
CAATTTTTATGGCTTTGAACATCCATTT
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AD” (SEQ ID NO:).
|
TTTGATGAGGCACATTTACCCTTTAGCCCATGTTAACATTTTCTTCAGGA
|
TTCATTACTATTAAAATTATTTATGAAAAAGTTTTTGTACTGGATCATTA
|
CCATCAGAATAATCAGAATGAATGCCACACTGAATATCAAAAGAAATAAA
|
ACTAAAATCATTATAAGGACACAACCATGTGATATTTGTCCATCTGCTCT
|
TTAAGCAATGTTATGTTATTTCTTGCAACCCCTACACAAAGGCCAAGAAA
|
TTACACAAGTACTAGTTTATTGGTTATTCACGGAGAGTGAGTACCTGAAG
|
GAGAAGGCTGTCCTTTTACTACACCATTTTTAGTCTTTTCTTCTGAATTC
|
ATTACTTCCTTGTAGATAAGTTCTGTAAGAAACAGCTGTGTTATTATAGA
|
AAACAAATTTATCCTTCATCCACAGGGAAATTCATTACTTAATGCCAAAT
|
AATTACGTTTTGATGGGGTTGAGTAAATTAAAAATCAATTGAGATTCCTT
|
TACTGCTCTATTTCTATTTCTATATTGCCTTGTAATTA [G/A] CAGAG
|
AGCCTGGCACAAATAGGTATCTAGTAAAGCAGTTGAAGAAATCAATGCAT
|
GAAAATTTATTTCTACGTACATGAAACATACTATTTATTTCCATATACAT
|
AGTATTTATTTCTACATACATTTCTACATAAATAACATTTATTTCTACAT
|
GCATGAAATATTTCTACATAAATGAAACAAGTAATACATGTTTTACTTGT
|
TTTCTGAATTCTTTGGGGGAAGTACTAATACATTCTAGCTCAATCTAGCA
|
ACAATTTTTATGGCTTTGAACATCCATTT
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AE” (SEQ ID NO:).
|
GGTATCGACAAACACTGACAATCAGTACCATTTTAAAACGTATCAATGGT
|
AAATCCCTTTCATTCTTGAGCAAA [T/C] GTGACATTGCTTTCGGCAT
|
GAAAAGACAGATGAAGTTTTAGGAGCTTTAAAAATGGTCTAAGAGAATAG
|
CAGTCAGCAAATCATTTTTTAGTAAATTGTTTTACAAGGAAAAGCCTTGT
|
TGATACTTTCTGAGTTCAATAAAATAAAAAGTATACTTTTTTAAGTAGTA
|
GACTTACCTTTCCATTCTTCAATTGTGTGTTCTCTTTCATCCAACTGCTT
|
GTCATATATCTGAGGTGGAGGCTGCCGAATAAAAACAAAAAATAATCTTT
|
GTGTGATAATGTAAACATAACTAAACTCTTACAATGCACGAGAATACCTT
|
GCCCTCATTTATTTCGGTGATTTCAACCGTATATAAGTTATGAGGAAATT
|
ACAGTAGTTCAGAAGTTAAAATTTTCCTGTAAACTTATGGAGGATTCATT
|
CATATTGCAATATTTGCTGCTGACCCAATATTGCTGCAATATTTGCAGCA
|
GAACGCAAATCCCGAGAGCTCACTTTCC
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AF” (SEQ ID NO:).
|
TGAGGGCAAGGTATTCTCGTGCATTGTAAGAGTTTAGTTATGTTTACATT
|
ATCACACAAAGATTATTTTTTGTTTTTATT [C/T] GGCAGCCTCCACC
|
TCAGATATATGACAAGCAGTTGGATGAAAGAGAACACACAATTGAAGAAT
|
GGAAAGGTAAGTCTACTACTTAAAAAAGTATACTTTTTATTTTATTGAAC
|
TCAGAAAGTATCAACAAGGCTTTTCCTTGT
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AG” (SEQ ID NO:).
|
GGTATCGACAAACACTGACAATCAGTACCATTTTAAAAGGTATCAATGGT
|
AAATGCCTTTCATTCTTGAGCAAATGTGACATTGCTTTCGGCATGAAAAG
|
ACAGATGAAGTTTTAGGAGCTTTAAAAATGGTCTAAGAGAATAGCAGTCA
|
GCAAATCATTTTTTAGTAAATTGTTTTACAAGGAAAAGCCTTGTTGATAC
|
TTTCTGAGTTCAATAAAATAAAAAGTATACTTTTTTAAGTAGTAGACTTA
|
CCTTTCCATTCTTCAATTGTGTGTTCTCTTTCATCCAACTGCTTGTCATA
|
TATCTGAGGTGGAGGCTGCC [G/A] AATAAAAACAAAAAATAATCTTT
|
GTGTGATAATGTAAACATAACTAAACTCTTACAATGCACGAGAATACCTT
|
GCCCTCATTTATTTCGGTGATTTCAACCGTATATAAGTTATGAGGAAATT
|
ACAGTAGTTCAGAAGTTAAAATTTTCCTGTAAACTTATGGAGGATTCATT
|
CATATTGCAATATTTGCTGCTGACCCAATATTGCTGCAATATTTGCAGCA
|
GAACGCAAATCCCGAGAGCTCACTTTCC
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AH” (SEQ ID NO:).
|
GGTATCGACAAACACTGACAATCAGTACCATTTTAAAAGGTATCAATGGT
|
AAATGCCTTTCATTCTTGAGCAAATGTGACATTGCTTTCGGCATGAAAAG
|
ACAGATGAAGTTTTAGGAGCTTTAAAAATGGTCTAAGAGAATAGCAGTCA
|
GCAAATCATTTTTTAGTAAATTGTTTTACAAGGAAAAGCCTTGTTGATAC
|
TTTCTGAGTTCAATAAAATAAAAAGTATACTTTTTTAAGTAGTAGACTTA
|
CCTTTCCATTCTTCAATTGTGTGTTCTCTTTCATCCAACTGCTTGTCATA
|
TATCTGAGGTGGAGGCTGCCGAATAAAAACAAAAAATAATCTTTGTGTGA
|
TAATGTAAACATAACTAAACTCTTACAA [T/C] GCACGAGAATACCTT
|
GCCCTCATTTATTTCGGTGATTTCAACCGTATATAAGTTATGAGGAAATT
|
ACAGTAGTTCAGAAGTTAAAATTTTCCTGTAAACTTATGGAGGATTCATT
|
CATATTGCAATATTTGCTGCTGACCCAATATTGCTGCAATATTTGCAGCA
|
GAACGCAAATCCCGAGAGCTCACTTTCC
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AI” (SEQ ID NO:).
|
GGTATCGACAAACACTGACAATCAGTACCATTTTAAAAGCTATCAATGGT
|
AAATGCCTTTCATTCTTGAGCAAATGTGACATTGCTTTCGGCATGAAAAG
|
ACAGATGAAGTTTTACGAGCTTTAAAAATGGTCTAAGAGAATAGCAGTCA
|
GCAAATCATTTTTTAGTAAATTGTTTTACAACCAAAAGCCTTGTTGATAC
|
TTTCTGAGTTCAATAAAATAAAAAGTATACTTTTTTAAGTAGTAGACTTA
|
CCTTTCCATTCTTCAATTGTGTGTTCTCTTTCATCCAACTGCTTGTCATA
|
TATCTGAGGTGGAGGCTGCCGAATAAAAACAAAAAATAATCTTTGTCTGA
|
TAATGTAAACATAACTAAACTCTTACAATGCACGAGAATACCTTGCCCTC
|
ATTTATTTCGGTGATTTCAACCGTATATAAGTTATGAGGAAATTACAGTA
|
GTTCAGAAGTTAAAATTTTC [C/T] TGTAAACTTATGGAGCATTCATT
|
CATATTGCAATATTTGCTGCTGACCCAATATTGCTGCAATATTTGCAGCA
|
GAACGCAAATCCCGAGAGCTCACTTTCC
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AJ” (SEQ ID NO:).
|
GGTATCGACAAACACTGACAATCAGTACCATTTTAAAAGGTATCAATGGT
|
AAATGCCTTTCATTCTTCAGCAAATGTGACATTGCTTTCGGCATGAAAAG
|
ACACATGAAGTTTTAGGAGCTTTAAAAATGGTCTAAGAGAATAGCAGTCA
|
GCAAATCATTTTTTAGTAAATTGTTTTACAAGGAAAAGCCTTGTTGATAC
|
TTTCTGAGTTCAATAAAATAAAAAGTATACTTTTTTAAGTAGTAGACTTA
|
CCTTTCCATTCTTCAATTGTGTGTTCTCTTTCATCCAACTGCTTGTCATA
|
TATCTGAGGTGGAGGCTGCCGAATAAAAACAAAAAATAATCTTTGTGTGA
|
TAATGTAACATAACTAAACTCTTACAATGCACGAGAATACCTTGCCCTCA
|
TTTATTTCGGTGATTTCAACCGTATATAAGTTATGAGGAAATTACAGTAG
|
TTCAGAAGTTAAAATTTTCCTGTAAACTTA [T/C] GGAGGATTCATTC
|
ATATTGCAATATTTGCTGCTGACCCAATATTGCTGCAATATTTGCAGCAG
|
AACGCAAATCCCGAGAGCTCACTTTCC
Following is a MAPK10 genomic nucleotide sequence that includes the MAPK10 SNP “MAPK10-AK” (SEQ ID NO:).
|
TCTCCATTTCTGCCATAGCACTAGTGAGTGACTTTGAGTTGAAATACAAT
|
TTAAAAATAATACATTCTCTCTCTTTTTTCTTTCTCTCGTTTCCTCTGTC
|
CCTTCC [A/G] CTCTCTTTCAGATTATTAGTTTATTAAATGTCTTCAC
|
ACCCCAGAAAACGCTGGAGGAGTTCCAAGATGTGTAAGTAACAAAACTCA
|
TGAAGGAAGGGAGAGCACAGCAC
Following is a KIAA0861 genomic nucleotide sequence (SEQ ID NO: 3).
|
>3:184201001-184348700
1aaagccaaga ctcccattcc taaaccctag ctcaggtctc catctcttaa atccgagtga
|
61cctctacaaa ctctccctga gaaggtgtcc agaacccttt tggaagcgag ggacagtgtc
|
121actgtctttg gggttgacac ctgctctgag taactcacgg aaaacaagtt ccagctggga
|
181agcccttgga cgcgccacac ctccctaccc gcagcccgtc ctgtggcgcc cgggactcca
|
241gagtgYgttt agatgaaagg ggaccgacac gtcagggcca ccgcgggaag cgctgagggc
|
301cactcaccgg ccagggacgc gaagagcgcg gccgccgcgc tgagctgccg gggcatggtg
|
361ggcgctgggc gaggttctgc agcgtgcggc gaRgtccggg caggccccga atcggtgcca
|
421gagaaaccta cctgtgccgg agaaacgaaa ccacctgctt atgagaagca gccgaaaagc
|
481ccgcccaggg ccgctgggcg gggagggaaa ctccgccggc cccctcctac ccctacggag
|
541cagggagggg cggggactcg gcgcagccgc cggggcccgg gcctctggga ccgtttaccg
|
601cacgcgcgtg gtcccggcag cgccggcStc ctccgctcat accctgggtc tcctcctttc
|
661tttttctttt ctttttgaga cgaagtctcg ctctgtcgcc cagggtggag tgcagtggcg
|
721cgatctcggc tcactacaac ctctgcctcc cgggttcaag cgattcttct gcctcagcct
|
781cccgagtagc tgggattaca ggcatgcacc accacacccg gctaattttt gtatttttag
|
841tagagacggg gtgtcaccat attggccagg ctggtctcga gctcctgacc tcgtgattcg
|
901cccgcctcga cctcccaaag tgctgggatt atagacgtga gccaccgagc ccggccaggg
|
961tctcctcttt tatttctttt ctttttattt cttttgtttt gttttgtttt gttttgtttt
|
1021ttgagacaaa gtctcgctct gtcgccaggc tggagtgcag tggcgggatc tcggctcact
|
1081gccctggttc aagcgattct cctgccgcag cctcccgagt agctggggtt acaggcgccc
|
1141gccaccacgc ccagctaatt tttgtatttt agtagagacg gggtttcacc ctgttggcca
|
1201ggctggtctc gatctcctga ccttgtgatc cgcccgcctc ggcctcccaa agtgttggga
|
1261ttacaggcgt gagccactgc gcccggccca gggtctcctc ttttctaaca gctcgggtac
|
1321ctttctggga acccagagac gcttctcagc cgggagaaag ccagccacta ggcgagcagg
|
1381agcctaaaaa cccctaagca ccctgactcc atgtcttccc agggagtctg cggcagccgc
|
1441gctccacgcc caggcctcgc caggaccgcg gtttgcggga agcaacagga gcacagccca
|
1501gaggcgctag gtctggctgg gagctcgcgc tgccgactcc ccggcgtgcg gcgtcgggga
|
1561acctctagga gccttggatt cttcagctgt aaaacggaca taataatgcc cactcccagt
|
1681ttgtttttga gacagggtct cactctgtcg cccaggctgg agggcaatgg cgtgatctcg
|
1741gctcactgca aacttgggtt caggcgattc tcctgcctca gcctccacag tagctgggat
|
1801tacagatgtg cgccaccacg tccggctaat tttttgtatt tttagtagag accaggtttc
|
1861accgtgttgg ccaagctggt ctcaaactcc tgaccccagg tgatccgccc gcctcggcct
|
1921tccaaagatc tgggattaca agcgtgagcc actgtgcctg gccccaggig gttttacaga
|
1981ccagaaaatc ctggaacaaa aaacacacaa tatcgttttt tttttttttt tggagtcagg
|
2041gtctcgctct atcacccagg ctggagtgca gtggcgtgat ctcggctcac tgcaacttcg
|
2101acctcctggc ctcaagtgag tctcccacct tagcctcctg agtagctggg accaaaggcg
|
2161cgtgccacca cgcccagcta ttttatttta ttttatgtag agaggaggtc tcgctgtgtt
|
2221gcccaggctg gtctcgagtt cctggcctca aatgatcctc ctgcgttagc caaccattgg
|
2281gattacaggc gtaagccacg gcccacggct caacaacgct gacaggcaac cttttaatgt
|
2341cttatctcct tcctctatta attggattgt ctgtcaaaac aacgatgttt tgacagggct
|
2401tgagtcccag tggggaatac acatttaagc agtatattag gagaccctcc ttatcactag
|
2461attgagggct ttcagcctag cctcaaatta ttttctgaaa aataactttg gctacaacta
|
2521ttttgtctta ctatgttgct ccaaacacta atcaagtaaa cttaaccaaa gcttgcagtg
|
2581tgtttcagaa tggaattttt atggtgaaaa gtgagggtta acttgtgcca gtcaacctag
|
2641tttcagcaac tacctgcttt ctgatctttg agacagttta ttcaaaagac gataattaag
|
2701tgggtataga ctgtgtgcca ggcactcttc ttattccatt taagcgccat agccactcta
|
2761tatggacact gttgttatta tcgctgcccc atttcgcaga tggagaaact aagcacaaag
|
2821aagggagttg cccagagtca cttagataat aaataccgaa acctgaccat aaatcttgtc
|
2881tgccttgaga gtctaggatt ttaagcacat agccgggcgc agtggctcac gcctgtaatc
|
2941ccagcacttt aggaggccga ggcgggcgga tcacgaggtc aggagatgga gaccatcctg
|
3001gctaacacag tgaaacccag ttctattaaa aatataaaaa aattagccag gcgtggtggc
|
3061aggtgcatgt agtcccagct actcgggagg ctgaggcagg agaatggtgt gaacccagga
|
3121ggtggagctt gcagtgagcg gagatcgcgc cactgcactc cagcccgggc gacagaagga
|
3181gactccgtct caaaaaaaaa aaaataaata aaataaagct gctcctctta ccctggaaat
|
3241tccaagggat ttaggagctc tgtttcagga accagggtca aagaccaagt attaaaacaa
|
3301aagattctcc tagaactctg gcatataagg attttaggag ctctgtctta gaaactggga
|
3361cagagaccaa agatatatta ttatatcgca gtatcatagt ttattatttt caaaaaacgt
|
3421tttctggctg gtacagtggt tcatgcctat aatccaagca ctttgggagg ccaaggtggg
|
3481agggtcactt gaggccagaa gttcaagtcc agcctgggca acacagggag accctgccac
|
3541tattaaaaat tttttaaatt agctgggcat ggtggcacat gcctgtagtc ccagctactt
|
3601gggaggctga agcaggagga ttgcttgagc ctgagaggtc aagactgtag tgagctgcga
|
3661tcaagcgact gcactctagc ctgggtgaca aagccagacc ctgtgtctaa aaaaaagaaa
|
3721agaagaggaa aaaaaaaggt ttttatttca actaagttgt tggatttatt agcataaagc
|
3781ttttcataac aatcccttgt cttacaatat ctgtagtata ggtagtgatg tcacttcttt
|
3841tattactaat attaataatt tgtattttct ctcttatttc cctgctaata ttaataattt
|
3901gtattttctc tcttttttcc ctgataagtt tggctggagg ttgatcaatt ctattcatgt
|
3961tttcaagaaa aaaaaaaaaa tttcatttca tcgagttcct tcattgttct tatgttttct
|
4021gttttattca tttctacctg atctttatta ttttctttct tctacttaac ttgtgtttta
|
4081tttgctcctc tttcaatagt tttcaaagat ggaacttgcc tgggatatcc cagcacttta
|
4141ggaggctgag gtgggaggat cacctgaggt caggagttca agaccagcct ggccaacatg
|
4201gtgaaactcc gtctctacta aaaatacaaa aattagctgg gtgtggtggt gggcacctgt
|
4261gatcccagct actcgggagg ctgaggcagg agaatcgctt gaacccggga ggtggaggtt
|
4321acagtgagct gagatcacgc cactgcactc cagcctgggt gacaggagct agactctgtc
|
4381tcaaaaaaaa aaaaagaaaa aaaaaaagat ggaagttgag gccagtggta taaaatcttt
|
4441cttcatctct aataaacagg tttactgtta tgaacgtccc tctaattact actttagttg
|
4501gatcccacaa gtttaatatg ttttcatttt catataatta gaaagacttc ctaatttcct
|
4561tttgctatct cctcgactca tggttattta aaatagcatt atttcatttc caaacatata
|
4621gtttttcaga tatctttctt ttattgattt ttaattccac tgtggttgaa aacataatta
|
4681tggacttaaa tcttacaaat ttattgatat ttgttttttg accaagacta tggttggtta
|
4741cattagtttt caggactgac ataacaaagt gccacagact gggtaattaa accacagaca
|
4801tttgctttct tataattctg gaaaccagac atgtgagatc aaagtgtcag ccgggttggt
|
4861tttttctttt tccttttttt tttttttttt tgagacagag tctctttctg tcacccaggc
|
4921tgggatgcag tggtgtgatc tcggcttact gcaaattctg cctcccaggc tcaagcgatt
|
4981ctcctgcctc agcctcccga gtagctggga ttacaggtgc ctctcactgc acctggctaa
|
5041tttttgtatt tttagtagag acggggtttc accatgttgg ccaggttgat ctcaaactcc
|
5101tgatctcagg taatacaccc gcctcggcct cccaaagtac tgagattaca ggcgtgagcc
|
5161actgcacccg gcccgggtta gttctttcta aggcctctct ccttggctag tagacacctt
|
5221tgtttcacat ggtcatccct ctgtgcatgc ctttgtctgt cctaatctcc tcttcttata
|
5281aggacattag tcaggtagga ttagtgccta ctctttgaac tcgttttacc tcttaaagac
|
5341cctatctccg aatatagtca cattctgaga tacttggggt taagacttgt attagtccat
|
5401tttcacgctg ctcataaaga catacctgag actgggaaga aaaagaggtt taattggaca
|
5461attccacatg gctggggagg cctcagaatc atggtgggag gcgaaaggga ctttttacat
|
5521ggtggcggca agagaaaatg aggaagaagc aaaagcagaa acccctgata gataagccca
|
5581ccagatatca tgagatttat tcactgtcat gagaacagca cgggaaagac cagcccccat
|
5641gaatacatta cctcttcctt ggtccccccc tccccacaat atgtggggat tctgggagat
|
5701acaattaaaa ttgagatttg agtggggaca cagccaaacc atatcattct gtccctggtc
|
5761cttccaaatc tcatgtcctc acatttcaaa accaatcatg cctttccaat agtccctcaa
|
5821agtcttaact catttcagca ttaacctaaa agtccacagt ccaaagtctc atctgagaca
|
5881aggccttccg cctatgagcc tgtacaatca aaagcaagct agttagttcc tagatacaat
|
5941gggggtacag gtattgggta aataaagcca ttccaaatgg gagaaattgg ccaaaacaaa
|
6001ggggttacag ggcccatgca agtctgaaat ccagtgaggg agtcaaattt taaagctcca
|
6061aaatgatctc ctttgactcc aggtcttaca tccaggtcac gctaatgcaa aaggtaggtt
|
6121tccatggtct tgggcagctc cacccctgtg gctttgcagg gtacagcctc cctccaggct
|
6181gctttcatgg gctggtgttg agtgtctgca gcttttccag gcacccagtg caagctgtca
|
6241gtggatctac cattctgggg tttggaggac aaaggccctc ttctcacagc tgcactaggc
|
6301agtgccccga tagggactct gtgtgggggc tctgatccca catttccctt ctgcactgcc
|
6361ctaagaggtt ctccttgagg gccccacagc ttccaccctc tgaaccatag cccaagctat
|
6421gcattggccc ctttcagcca tggctggagc agctgggaca gagggcacca agtcactagg
|
6481ctgcacacaa catggggacc ctgggcctgc cccacaaaac ccctttttcc tcctgggcct
|
6541ccaagcctgt gatgggagag gctgctgtga aggtctctga catggccttg gagacatttc
|
6601cccatggtct tggggattca cattaggctt cttgctactt atgcaaattt ctgcaaccag
|
6661cttgaatttc tccccagaaa atgggttttt cttttctgtc acatagtccg gctgcaaatt
|
6721ttccaaactt ttatgctctg cttcccttat aaaactgaac gcctttaata gcacccaaat
|
6781cacctcttga atgttttgct gcttagaaat tttttccacc agatacccta aataatctct
|
6841caagttcaaa gttccacaag tctctagggc aggggcaaaa tgtggccagt ctctttgcta
|
6901aaacataaca agaggcacct ttgctccagt tcccaaaaag ttcctcatct ccatctgaga
|
6961ccacctcagc ctggatctta ttgtccatat cactatcagc attttgggca aaaccattca
|
7021acaagtctct aggaagttcc aaactttccc acattttcct gtcttcttct gagcccttca
|
7081aactgttcca atctctgcct gttacccagt tccaaagttg ttccacattt tcaggtatct
|
7141tcagcaacgt ttcactctac tggtagcaat ttactgtatt agtccatttt cacactgctg
|
7201ataaagacat atctgagact gggaagaaaa ataggtttaa ttggacttac agttccacat
|
7261ggctggggag gcctcagaat catggtgaga ggtgaaaggc acttcttacg tggtagtgac
|
7321aagagaaaat gaggaagaag caaaagcgga aacccctgat aaatccatca gatctcatga
|
7381gacttattca ctatcacgag aatagcatgg gaaagaccgg cccccatgat tcaattacct
|
7441ccccctgggt ccctcccaca acacatggga attctgggag atacaattca agttgagatt
|
7501tgggtgggga cacagccaaa ccatatcaag acttctacat atgaattttg gagggacaca
|
7561atttaactca taatagtgga ctgtcYtgtt aaatgttctg tgtgcacttg agaagaatgt
|
7621gtgtattctc tcattgttgg attcagtgac ctataaatgt taattaggtt aaactaattg
|
7681atgtagggaa aagaaagaga gatcagactg tcactgtgtc tatgtagaaa gggaagacat
|
7741aagagactcc attttgaaaa agacctgtac ttcaaacaat tgctttgctg agatgttaat
|
7801ttgtagcttt gccccagcca ctttgcccca gccactttga cccaacttgg agctcacaaa
|
7861aacatgtgtt gtataaaatc aaggtttaag ggatctaggg ctgtgcagga cgtgccttgt
|
7921taacaaaatg tttacaagca gtatacttgg tcaaagtcat cgccattctc tagtctcaat
|
7981aaaccagggg cacaatgcac tgcggaaagc tgcagggagc cctgcccttg gaagcggggt
|
8041attgtccaag gtttctcccc atgtgacagt ctgaaatatg gcctcgtagg atgagaaaga
|
8101cctgactgtc ccccagccca acacccataa agggtctgtg ctgaggtgga ttggtaaaag
|
8161aggaaagcct cttacagttg agatagagga aggccactgt ctcctgcctg cccctgggaa
|
8221ctgaatgtct tggtgtaaaa cccgattgta catttgttca actctgaaat aggagaaaag
|
8281ctgccctgtg gtgggaggtg agacatgttt gcagtaatgc tgccttgtta ttctttactc
|
8341cactgagatg tttgggtgga gagaaacata aatctggcct atgtgcacat ccaggcatag
|
8401taccttccct tgaacttaat tatgatacag attcttttgc tcacatgttt tttgttgacc
|
8461ttctccttat tatcaccctg ctgtcctact acattccttt ttgctgaaat aatgaaaata
|
8521ataatcaata aaaactgagg gaactcagag gctggtgccg gtacaggtcc ttggtgtgct
|
8581gagtgccggt cccctggact cactgttgtt tctttatact ttgtctctgt gtcttatttc
|
8641ttttctccgg ctctcatccc acccgactag aaatacccac aggtgtggag gggcaggcca
|
8701ccccttcaat tgatagtatg gttcaagaac aaatggtatc aacttaggat ggtttaactt
|
8761atgatttttc aactttagaa tggtgtgaag tctgtatgca ttcagtagaa ggcatacttt
|
8821gaatttttat cttttcccaa gctactgcta tgggacaaga tactctctca caattctggg
|
8881cagtggcagc aagcctcagc ttccagtcag cacccaatcc caagggtaaa caactgatac
|
8941agccattctg tttttcattt ttagcaaaat actcaataaa ttacatgagg cactcaatgc
|
9001tttattataa gacaagcttt gtattagatg atttgcccaa ctgtaggcta atgtaggtgt
|
9061tctgagcaca tttaaggtag actatactat gccatgatgt ttggaaggtt aggtaaattt
|
9121aatgcatttt cgacttagaa tactttcagc ctcccaaata gctgggacca caggtgtgtg
|
9181gcaccatgtg tggctaattt tttgtggaga caaggtctca ctRtgtcgcc caagttggtc
|
9241tcaaaatcct gacttcacgt gatccttcca ctctggtctc ccaaagtgcg attacaggtg
|
9301tgagtcacca cacctggccg tgttgtcaca cattttaatt ctttataaat tagaaacttc
|
9361acaacacatt gttcttattt aaaatttaaa caattatctt taaatataca taatatataa
|
9421atatgtatat aatatataaa tatatacaat atataaatat ataagatata ttatatatat
|
9481aatatataaa tatataatat ataaatatat aatatgtaaa tatataatat ataaatatat
|
9541gtaaatatgt aatatgtaaa tatgtaatat gtaaatatat aatatgtaaa tatataatat
|
9601ataaatatac ataatatata aatatataat atataaatat ataatatata aatatataat
|
9661atataaatat ataatatata aatatatatt atatataaat atataatata cataaatata
|
9721tataatatat aaatatatat aatatacata aatatataat atataaatat atataatata
|
9781tataaatata tatggggaaa aaagctttta tacttactca tgtgattacc gtttcttgca
|
9841gtctttattc ctttgtttag atccttggga tttttgttgc tatggtgacc ttagttatac
|
9901caggcacttc aaatcttacc ttgtgtttag gaWatgggct tgtttgccca aaggtcttcc
|
9961ctaatgtctg ctccaccttc aactttaggt cttctctgct gtcagtttct ctctccatac
|
10021acttgtagct ctcccaggag tattccatcg ttacttgtta gtcagtgctt attagcgggg
|
10081tggtgggatc tgagaggtga ggtgcttggt tgtgattctc agttctgatt cctgcaggta
|
10141ctgtgtccct gggYcttgaa gggtatgacc aagcStctct gtccctcccc gcagcagtag
|
10201ttttgggctc agcacatatt cctgcccctt ccccagaatc agagggtttt ttgttgttgt
|
10261tgttttgttt ttcaagtttt tgttcctttt tctccatctg tgttggattt accagccccc
|
10321taggagcgtc agtatttgtt acccttcctc caggctttta aggcctttgt aggagagatg
|
10381ggccaatagc atctgagcat ggttttgtgt ctttcttgta gcaactgata ttcctcaccc
|
10441ccaggtctat gccaggaagg atgcttcctt acatgcctgt aatcccagct accggggagg
|
10501ctgaagcaga agaatcactt gaacccagga ggcagaggtt gcagtgagcc aagatcatgc
|
10561cactgcactc cagcctggca acagagcgag acttcattca aaaaaaaaaa aagctcttac
|
10621actcttctgc atattctgca aagtatactc tgggaaggct ggtttagagg atctctaact
|
10681tttctaatat ttcataatgc atggctgatg tttaacatga actcagactc ccatcagatt
|
10741ttacagatct gggtctgctt ttagttctaa tgcttcagcc agggcacttt aatctgaggt
|
10801cacagcattc ccaattgtca gcagtatttt gaaatctaag ttcctctggt ggacaacagg
|
10861caacatcata tagccaYgga ggatctgaac aacttctaag tctgagSgat tttatctggt
|
10921ggttttggat tcttttccat ttatacttaa acaaggtgac acaaatgtca ctcacagaaa
|
10981agccactctt ttttcccctg tttttaagaa gtctaaaaat gcacaactat ttcctgaatg
|
11041agcagtgtgt ccaggtgtag aatagggaat gtcgtgtcca ctgggaacag acggtgtacc
|
11101tggcacaatt ttatgagaat tatcccatga ttcctgtccc accctgcagc ccaCcatggg
|
11161ctcagtgggg agtctgagtc tctgagcccc aaagggtagc tttttcccag acgacaccag
|
11221caagcagagc agcagcttgg ggctttgaca aggaggctgg agtgaaaggt catattggac
|
11281catcctggRt cactggagga caatacccca ggaacctcca gcaatgactg gtattggaat
|
11341gactcccctg gtcacccacc tgtggcaaga catttgcaaa cagggtcttc ctatgaggct
|
11401tgtgaggttt ggccaatttg cattctgcta gaattattaa gtatggacat cctcatagat
|
11461ccagaaaagg gccgagatcc aaaggattga gaatgctttg gggggtgttt ccatagtgag
|
11521tggctggcta ttcaacagtc aaatgtttga gaggatacaa gtgatgtgtt tcctgaggca
|
11581agtggtcaga acccaacaga ctcttctgtt cagctaagat gagagaccat ctgaagttct
|
11641tacatgttct cacagagaaa tggattctca tagggaaatg gatatattgt gatagacact
|
11701gtaagcagag aagttgactg agaaacacac acacacacac acacacacac acacacgtca
|
11761agactgaatg catagatgtg tattataaaa agYgtaaaaa tacaccacca ttStaacaga
|
11821ttgtgtagga ctatattttc ttttttttta atttattatt attatacttt aagttttagg
|
11881gtacatgtgc acaatgtgca ggttagttac atatgtatac atgtgccatg ctggtgtgct
|
11941gcacccatta actcgtcatt tagcattagg tatatctcct aatgctatcc ctcccccctt
|
12001cccccacccc acaacagtcc ccagaatggg atgttcccct tcctgtgtcc atgtgttctc
|
12061attgttcaat tcccacctat gagtgagaat atgtggtgtt ttgttttttg tccttgcaat
|
12121agtttactga gaatgatgat ttccaatttc atccatgtcc ctacaaagga catgaactca
|
12181ccatttttta tggctgcata gtattccatg gtgtatatgt gccacatttt cttaatccag
|
12241tctatcattg ttggacattt gggttggttc caagtctttg ctattgtgaa tagtgccaca
|
12301ataaacttac gtgtgcatgt gtctttatag cagcatgatt tatagtcctt tgggtatata
|
12361cccagtaatg ggatggctgg gtcaaatggt atttctagtt ctagatccct gaggaatcgc
|
12421cacactgact tccacaatgg ttgaactagt ttacagtccc accaacagtg taaaagtgtt
|
12481cctatttctc cacatcctct ccagcacctg ttgtttcctg actttttaat gattgccatt
|
12541ctaactggtg tgagatggta tctcactgtg gttttgattt gcatttctct gatggccagt
|
12601gatgatgagc attttttcat gtgttttttg gctgcatcag tgctctacac gttcagagaa
|
12661acttctctag tgacgaacta tagaaatgat ccctgaaagt atagtcttag gactatattt
|
12721tcttttgact tgggaggcat gtttattgct gttaatgctg caaagggctc tacgtgcttt
|
12781aaaaaatccc aatctgttgc attcataagc ctgggttgga tctaaagcag cctcccactt
|
12841ttggaaaggc atccccacga cctttccatg gttgctgaat gcagctggag gcagtcacag
|
12901ctggtgatgt ccggagccca ttccccactg tgctggtctg cagaacttct gcatgccatt
|
12961cccacaagca ggtctctgcc ctgctctcct ccacctccct tgtcagagga agtctgcact
|
13021tcacagcttt ctggtctcaa ccctcctcca tccctacaga tgtgtaagca gcaggaatca
|
13081aaaggtgaag gagagggggc aactcacctc cgatggacac gtgaaaagtg ggagatggat
|
13141aaaatcaaga aggagcttaa gatatccaga aatgtaaact gtgtttggaa aagtaaggtc
|
13201aggagaagca tgggactcct gaggttgctc cctactatct tgcagacttg ctgcaggacc
|
13261aaatgaagca ggatctgtca agcaccaggg ccagctctta agcttagtgc ctttctgaac
|
13321cctgtgaccc agcagcctcc atcaactcgt cctacctgcc atgcacagct cctctgtgcc
|
13381cctgtacctg agctcatgct attccctctg ccaggatgcc cttctccttc tccaccagga
|
13441gaagaacact tgccagtaag acccagttct aatgtcaccc cttcctgacg gtatcaggaa
|
13501gagtcaStga tggtgtttta tgctcccaga gaatttgcca cattgtgttg tgattatttt
|
13561tccacatctg tctcccccac tggaatgaga gcctcactca tcttcatacc tccctggtct
|
13621ctacctggtg ccagaaccat cctcagggca ggggaatgct caggaaatag atattgaata
|
13681aaataagtgt atccatccat ccatccatcc atccttccat ccatccagac atatatacat
|
13741atgtaaacat tctgatggtc aaatggaaca atgtgggctg aagaataatg caggtagaag
|
13801aacctaagat tacagattct tgatttggga ggaactttat tttattgtgc aaacagtcta
|
13861caaatttgaa acatactcta tcaagaaaga cactgttgtt aggaaagggc gtgggagagg
|
13921gtggccccac aaaacagtgt aaagttctaa agaatttgag aggaacactc tgcgggaccc
|
13981tgttccaagg gcatctttct aagagtctgt cccttaggct ctgccccttt ttggccacgt
|
14041tgtcaaaggc cttctttatg aacgaagtga gacacattat ttttgttttc ttgaattcta
|
14101aagtgattgt cttgagttcc ctgggggaga ctcctgggag gtgtggccca ctctattcca
|
14161gaaacaaacc aggagactga agactcatcc caatcccata tcccatgaaa atgtgaaatc
|
14221aaatcacccc tgacaattcc aaaactaaYg gaatcctaac ataactctat gtaactctaa
|
14281agctgagtgt gctggtaatt aagcttccag cccacccttc ccagctctgg ggtgcagggt
|
14341caccatgggc tccttcctgt gtgcacccca ccccaccccc actgtcagca tcctgtctcc
|
14401accctgagag tgacagctgg ttccagtagc gggagttggt tccagcttgc cattttccta
|
14461gcactcctat aaccagcctg ctgatgccca ttcagagaca gcagcacggg ctggccatgt
|
14521cccctctcca gaattctgcg tccagctcct ggaccttgag ctctgagccc ttgggccacg
|
14581tgtacMatta atagtgcctc ctcctcagag gactaacccc cagccctagg gccaccttca
|
14641tatttcYgag ttttgatatt ttcaacctct tttctttgtt gtatgagtcc ttgggctggg
|
14701agcttgcagt caaaatcttc atgatatctc attatcacta ctttttttta aatctctact
|
14761agctggataa caattattta tattaaattc tctcttgaaa taactgatac agtgtctctt
|
14821gattgaaact tgactagtag actaagaatt ctaactctaa ataattctga gggccgggtg
|
14881tggtggctca cacctgtaat cccagcactt tgggaggcca acgcgaatgg atcacctgag
|
14941gtcaggagtt ggagaccagc ctggcaaaca tggcgaaacc cggtcaggag atccagacca
|
15001tccYggctaa catggtgaaa cctcatcttt acttaaaaaa aaaaaaaaat acaaaacaaa
|
15061attagccagg cgtggtggca gatgcctgta gtcccagcta ttcaggaggc tgagacagga
|
15121gaatagcgtg aacccgggag gtggagcttg cagtgagccg agattgcacc actgcactcc
|
15181agcctgggtg acagagagag actccgtctc aacaacaaca acaacaaatt agccgggcat
|
15241ggtggcaggt gcctgtaatc tcaactactt gggaggctga ggtaggagaa ttgcttgaac
|
15301ccgggaggcg gaggttgcag tgagccaaga ttgcggcact tcactccagc ctgggtgaca
|
15361agagcaaaac tccatctcaa aaaaaaaaaa aaagaaaaaa aaatctgaca attaaataaa
|
15421gaacagaaaa aaaatttgaa tggcaaatac aaagctgaaa agaaataact gagaataaat
|
15481aactctgaaa atagctcaaa aactaaatac ctcaaaaact ctttaaaaat tcagaaaata
|
15541taatgttcaa atatgaagta atgctgaaaa tgaaataact aaaaaccaag taacttgaaa
|
15601aaaagaacat aaaaataaac aactcaaata taaaataact gaaaataaat acctgtgaac
|
15661ataagcaact cgaaaaccag ataactaggg gaaacccttc attaaaacat ttcactctga
|
15721aaataaataa cttgacagta gttcatgaac ttccagtgag tgtttaatag tcaaataagt
|
15781tactgtaaaa ataaataact caaaaactcc aataagataa agtgaaataa ctatgaaggt
|
15841aaataactca gataataatt gtaaagataa ttaaaaataa attccggctg ggcgcggtgg
|
15901ctcacgcctg taatcccagc actttgggag gccgaggcag ggggatcacg aggtcaggag
|
15961atcgagacca tcctggctaa cacggggaaa ccccgtctct actaaaaatc caaataaaaa
|
16021attagccggg cgtggtggcg ggcgcctgta gtcccagcta ctcaggaggc tgaggcagga
|
16081gaatggcgtg aacccgggag gcggtttgca gtgagccgag atcacaccac tgcactccag
|
16141cctgggcgac agagcgagac tccgtctcga aaaataaata aataaataaa taaataaatt
|
16201ccaagcaaat taatttgaac atctgtaact cctaaaacaa aacaactaca tataaataac
|
16261tgaaaatgaa caactaaata actttgaaaa taaagtaact ataaaccagt aactgaaact
|
16321ataaaattaa ataaccagaa agctacaaag aaatgaaaat caactaataa aactaaaaat
|
16381aaaatacaac tgaaactaac aaaactcatt taaaaactaa taaatcgata cataaaatac
|
16441ctcagaaagt aacttggaac gaactctctc tacaacgaag caatcttggc actaacacga
|
16501acaccccatg aacgctcgca gggatgctgg gaggcggacc gggagctccc agtctgcggc
|
16561ccccgccggg ttKgagcggc tccggctcct ccaaggctcg ggctaagcgg ctctcaaccg
|
16621attcccaccc cgccctggag aaatgcgggc gtgtctgcag gcatttttga ttgtcacgat
|
16681ttgggggcgg ggtggaggat ggggtggcgc attcctggca cctagtgggt agaggccagg
|
16741ggtgctacta aacatcctac cgtgggagca cagagaagcc cacgcagcaa agaattgccc
|
16801ggctccgaat Rtcgaagtgc gcggtcgaga aggcgtgggc tgcgggctct gctcgcctct
|
16861gcaggcgcct tagagcagct ccgaggtccc ccgtgcggag ctaggcgcgc acccaggaca
|
16921cccctcgggc tcctcggagg aggccctggt tgtccccttt ctgccgccgc cgaggctccg
|
16981gctgctttct gcgtagctgg gcagggcccg ggcccccaca ccgcctctcc cgggaatgcg
|
17041ggcgctctgg agccgaggag cgggggcgtc cgcagggagg tcagctctcc tgggcggagg
|
17101tcctcgggcg cagcgccctc gcctggaaac cagccgtcgc ccccgcagga gccagccggc
|
17161ccgtggacgc cccagcgcgc tcctcctcgg tgctgcgggt cgccctgcaa ttccgagaag
|
17221aaagtcagag acgccgtggc ccaaagaggc gcttagtctt tcctcgctca cactcacgtt
|
17281tcctcctcat cgcgttcttc tttttctccc tggctgcttt ctcccctctc caggaaagca
|
17341gatttggagg aacaggtttc gtgactgtcg tccgactgga aaaggcccgc gagctggaag
|
17401ggaggggacg ggtgcaccct cagagttatt gctggaggct gtggccagac cgggcaaggt
|
17461ggtgactccc gctggcaggc tgaggcccac cccagccctc ccacctgggc cacggggctc
|
17521tcagcgggag ccccagttat gaccggacac cagcgcaccg ccaaggagac agccacgtgg
|
17581ggacatgctg gactaggagg gtcagagcca gtttgagggt ctggtgacct cggctccctg
|
17641gcttaaccag gtccttatgg gtgagaatcc tgaggagggg gagagggatg gaggctaggg
|
17701acaggaggca ggaggagctg atgaatagga aggagggaag aagatgaaag aaacaaaagg
|
17761gaagtaatta cactcagagc actgctctcc ttttccatgt cttctgcgcc ttcacagtct
|
17821tcaaaggtgt ccatggagct aaactccctg ctggagcagc cttagggaga gaaagggaag
|
17881gatggggcct ctgtggggtg ggaggacatc ccctctgccc atggcagggt gtagcaggca
|
17941gtgcctgttg caggcacggt cctccccatc tctaactcct gctctccaag ggcctgcact
|
18001gcgctgggct gtgagggggt ctgtgatctc caggctgctt ttccagcgcc gagatgccgt
|
18061aattcaccga gaaggcgcgt ccacatgctg ttcatggccc tacctccccg ttcctccaag
|
18121aaaacagtca ttgttttttg tgtttgccag tcttctaacc acgcctcctt cccttcctcc
|
18181tcccctgtct ctttctcacc ctcccctcct tgcctccttt tctctcccct aattaatgtc
|
18241catttcccat ctccctggca gcctctgcca agtgtcactg ctccccataa gggaaaatca
|
18301gaggaacaag caagtgcatc catcctgcct ctctctgcag tgaactgatt aattaatcca
|
18361tcagtcttgt ctatggcgca catgttacat ccctggggcg gtgttggaca ctgtggggaa
|
18421cagcagccac tgccaaatac tgaacaactg ccctgtgcct ggtggtatgt taggcatttg
|
18481tcaaagttta agcctcacaa ccctgtaagg gtctcagccc cctttacagt tggggaaaca
|
18541gacagcaatg gtcacttggc caagtcctct tggcctgtgg cagggcagct gtcttctcca
|
18601gcactcctgc tctttaccct cgctctgagt gagatggagt ctctgcccca catggctcac
|
18661aagccagggt agggagcaga gcatctgcag aaaggtccca acacaggaca gccccagacc
|
18721gagggtcagc tgagtagtct acgcggcggg agccgtgcta ggaaagtgtc tgctcaggcg
|
18781agaattcagg gaggtttggg caggacttga ggggcagaca ggactggaga gggagggcat
|
18841tctgggcaga ggcatggcca gagggcggta ggcggcagtg gagggagctg cagttatctg
|
18901ggtgagcagg cagcacaagt Rgcgtctcct gggctgctgc cccaagcccc caacaagcca
|
18961cgttctgggc cccaggccct ccccagagca gatcagtggg ggctgtgtga gtaacatggg
|
19021ggcggggggg cagctgggca gcacctccct ggaggcccct ctgaaatcct gcctgactct
|
19081ggcaggctcc gagggggctg gacaccctcc tctcaggttg aagcaagtcc tggttgagtt
|
19141cctagtccca ggaggtggga ggggcaaggg gtggagggca gaggagaaac tgcctcaggg
|
19201atgtgccccc tgccttcatc ctccagacag gacttgggag catctaagga aacccaagac
|
19261tcctctttag agaagtcatc cagccctggg gtccccttat gccaggagca agcagtgaga
|
19321atggaagaat gattgtcttg ctgaaagttc tgtgatggag ggatagaggg acagagggag
|
19381ccatgccctt gaccatcccc tgcatgaata ggaagggctg tgtctccagg gtccatggcc
|
19441tctgtgcccc ggatgatgcc agggctgcta gggaccatag agccacccac tgggaggctg
|
19501gcggttgggc ctggctcagg agccttcgtc agccataggc agccacagcc tggggtgggc
|
19561agggctggga ggcgacacag gaactgaaaa acctgacaag ctctagcccc tccgcagggt
|
19621aagtggtacc tccaggtaaa atgattagtt Kgttccagcc cctctgcagg gtaagtggca
|
19681cctggggtaa aatgactgcc tggagctggc agctgctttc cctgctctcg cgggccctgc
|
19741agggaagcgg ggaagggaag ggggcacagc gctgggcaca gaggggctct cagaccctgg
|
19801actcaactgt ttcagggtca tctgaaacag tcaactgttt cctctagccc attccctgcc
|
19861tccaggcgag gatttgcctg aacgtggaaa gaggaaggat cctcccagtg ctgtcaaccc
|
19921cagattccac ctccctgtgg gggactgtca gcgcaggccc tgacaacgca gagaaagaca
|
19981caggacccac ctgggccagt gacagcagga gctccgggtg ccacaggtga gggtggggat
|
20041gcctggagca ccacgggggg cctggtttag tctagagcca ggttttccat acaccttaga
|
20101gtgcaacctc agggagatgc aaattttacc ccctaacaca gcatacacgc agaaacacat
|
20161ttatacaatt caaacacaag cggacggaac aatatttacc cttagagtgt gtgaagtcct
|
20221catctgtccc acctcatcct atcatgcttt gttctatcct aggagacaaa gcaggagggg
|
20281gggctgcgga ggtgggggag tctcatccaa gcccttgggt gacacgtctc tcctgagaca
|
20341aactgcagct gctctgggtg tgccctcgcc tgtctccctc caggccccgg gttcctgcca
|
20401gcagagacag taacctattc accaggtatc ccccagggct cctggaagaa actcagaatt
|
20461ctcagaacca gaaaacctta gagagcatcc tgcaggcaaa gcccctggtt ctctgcggag
|
20521gaaagtgcgg ctcacagggt gccccgccag ggatggtaat tgacYaccag gctgtgtgcc
|
20581ttgtggggac tggcttaagg ccctgtggga gctgagtcag ggccaggacc ggggtgtcct
|
20641gactcctaga gatcatgttc ccttcctcac ccaggccttc cagtcccagc cctgggcttt
|
20701tatttattta ttttggagac agagtctggc ttgtcaccca ggttggagtg cagttgtgtg
|
20761atcacggctc actgcagcct tgacttcctg ggttgaactg atcctcccac atcagcctcc
|
20821tgagtagctg ggaccacagg cacatgccac cacacccagc taatttttgt attttttggt
|
20881agagatgggg ttttaccatg ttggccaggc tggtcttgaa ctcctgagct caactgatct
|
20941gcccacctca gcctcccaca gtgctgggat tacagatgtg agccatcatg cccacctcct
|
21001gggctgactt ttgctgtctt acatcatctg catatttaat cccctgctgg attcactggt
|
21061catgggctct gaggccctaa gagtcttagg cactaaggag ctggcagcac tgaggggacc
|
21121ccaaaatctc agactcagga tctggccagt cacaggcatg tgagggaaca actgagaggc
|
21181ccattgcccc atggcaggag aaggtgctct ggagtcagtc agacctgagg gcagtcagac
|
21241ctgattctca ctctgtcact cactagctgt gtgatcttgg atacatcact taacctcttg
|
21301agcatcagct tccttatctc taaaatggag ataataacat cgattttgca gtcttggtat
|
21361gaggattagc aaatcttctg ataaagaaaa atgcctggta catcatagga attcaacaaa
|
21421tagtacctgt tatgattatt gtgtatagca attacaataa tactaaagag agggtctcaa
|
21481aacagctctg ggcactccag gtgtgctatt attacttaca tttcagggag gtttgtctgc
|
21541cattgtctca tcctcataaa cactcaggga aagaaacatt ataaggataa taaatggctt
|
21601taaaaagaaa cagagcaaac acacacacac acacacccct cagaaaaacc atgccaaaca
|
21661cacaggctct tgacaaatat tcaatctgat tatagcaaaa ctgttttgtt ttgttttgtt
|
21721tttttgtttg tttttgagac aggggtctcg ctctgtcgcc caggctggag tgcagtggcg
|
21781tgatcttggc tcacagcaac ctccttctcc cgggttcaag caattctcct gtctcagcct
|
21841ccagagtagc tgggactaca ggcacatgcc actatgcctg gctaattttt gtatttttag
|
21901tagagacagg gtttcaccat attggtcagg ctggtctcga actcttgatc tcaggtgatc
|
21961cacctgcctt ggcctcccaa agtgtgagat tacaggcgtg agccaccatg cccagctgat
|
22021tatagcaaaa ttctaagtga tagttgtatt cttggaaaat gaatggaacg acttttgtcc
|
22081cagccaagat ctagtggtgt gttggagcag atacaccctg agtctctggg gcactctcag
|
22141tctatgtatc agataagcat aaggagtatt ggtggagaag gacaagaatg ggaaaggtgg
|
22201gcgatgagaa ttcctgcaga taaggactgg tgagagtatt ctcttttgaa acccttagtc
|
22261gacaatcttt ctggtgcata tcagataagc tgaatggttt aggaaatcta gtgttcacat
|
22321ttagtgctta gaattctaag cttttttatt ttgcttaaac aaatggaatg aaatttatta
|
22381acaagtgaac ctagtaatga gctgaaatta ttctcaccag catacatatt tttggtaaat
|
22441tatagacttt gaagacaaaa tcatggtgtt tcccttactg tccagtggat ggcacaaaga
|
22501gaccattgta gatcctgctg gttcagcggt agctctcaat ccatagatat taaatgggca
|
22561aattctattt ttattgtctt tcaaactaga tttttctcaa tgcacaactt tttttttctt
|
22621tttctttttt ttttttgaga cggagtctcg ctctattgcc aggctggagt gcagtgacac
|
22681gatctcggct cactgcaacc tccgcctccc gggttcaagt gattctcctg cctcagcctc
|
22741ctgagtagct ggggactaca ggcgcatgcc accatgccca gctaattttt ttgtaatatc
|
22801agtagagaca gggtttcacc atgttggcca ggatggtctc gatctcctga ccacgtgatc
|
22861cgcccacctt ggccttccaa agtgctggga ttacaggcgt aagccaccgc gcttggccaa
|
22921ttatgcacaa ctttttaagg accatctcta tcacatgaac taaaggatat cattttcact
|
22981tgggggtggg aagtggtgag ctgcttaaaa gcaatgccta aaccccctgg gctttccttc
|
23041ctttcacttg gaagaaccag ggggtaacta actgctaaca attccatgct ttcagagatc
|
23101taggcgcaag cctaagggct tcatctcatt taatcctcat ggcaagactg tacagtatta
|
23161tctccatttt gtaaaatgaa tgataaaaag aacttaagca cagacaggct atagaatcca
|
23221tccaaagaga tggagctgca cttgaggctg ggtctttgag acctgagttt gagcccttca
|
23281tcattgtgtt gtgtgtgctg ctaaccaatt tcccctctct gtcttctagg atttaataca
|
23341tggtgtcaca ttctgtctga tccatcccag tagctctcca gagctcccaa caggagagag
|
23401ttccaaaatg tttccagggg tactaggctc ggttacaata ttttgcttgg tggcccagag
|
23461tataaacgtg gatatcttag gctggtctat agctgaaacg tctatttcat ttgcaagcct
|
23521atctttggct aagaggaagt gaatcattct tgagaacatc taattaattg ctttcagatt
|
23581ccacatgttg acattctcag ggcacatttt ttttttcccg tgcatttctg ttgtcaaagt
|
23641ccctgccagc tcctaaggca gtctgagctg gctgtcttag actttcagag ctgctggaag
|
23701cttgggggag ggaggggctg taggtcaaag aaactttata acctagcttt acctcccagc
|
23761tcagccacca gctgccctca aatgttctgg attggaataa gcccaaagat gagtggcagg
|
23821agggaagggc aagccaatac gtctagtttg gttcagtcaa agccttgccc atttcatcag
|
23881aattttaatg gaaaatttcc aataagatta aaatataagg tcaccccaat tttagtatgg
|
23941ctccatttaa aaaaaatcat gcatatcttt gttttgcaat ggggccttac tcttgcccag
|
24001gagaggtgcg gtggtacaat catggcttac ggcagcctca acctcctgag ctcaagcaat
|
24061cctttcacct tggcctgcca aatagctagg attacagaca cccaccacca tgcccagcta
|
24121atttttaaaa aaaatttttt gtaggtccag tgcagtggct catgcctgta aatctcagca
|
24181ctttgggagg ccgaggcaag cggatcacct gaggtcagga gtttgagacc agcctggcca
|
24241caatggtgaa actgccgtct ctactaaaaa cacaaaaatt agcgaggtgt ggtggtgggc
|
24301acctgtaatc ccagctactc gggagactga agcaggagaa tcaattgaac ctgggaggtg
|
24361gaggttgcag tgagccaagt tcgtgccatt gcactccagc ctgggcaaca agagtgaaac
|
24421tccgtctcaa aagtttttgt ggagatgggg tcttgcgata ttgcccaggc tggtctcaag
|
24481ctcctggata tcaagtgatc ctcctgcttt ggcttcccaa agtgttggga ttacaggcat
|
24541gagccaccac aactgaccaa atcatgcatt tctatagaca acgtctgcaa gaagatatta
|
24601atggtgatta tatctggtta tgttggattt gtatttttat ttgtactttc ctgtattttc
|
24661taaattcctg acattctaca tgtgtactcc tttaataatc agaaaaggaa acttaaaata
|
24721gttaaaacca attggtcaga tatgtaaaat aacccaccat ctctccagag agggctgttt
|
24781gctagaactt attttcttca ttgaaatact agagtgcccc aataagtttg aataacacaa
|
24841aaaaaaagat aatgaaagta actaaattat ctaggcccaa aaggaaatgc cacaaaaatt
|
24901ggcaaagaaa caaccatgac gtgctatacc ggatagctcc taggccccct tggagaccct
|
24961gaggtacccg acgagggacc tgtagtaagg ctggcagaca ggttcttcct ctgttagctc
|
25021tgaggtacaa cagttattct catttttatg tctttcacat ggccagaact ttgcaaatca
|
25081gaggcaaagt gaattcagaa ttaaaaattt tcagcaccat ccaagtcagt aaaacagtct
|
25141tagcttataa cctttatttt ttttattatt ttattatttt tttatttttg gatggagtct
|
25201tgctctgttt ccaggctgga gtgcagtggc atcatctcRg ctcactgcaa cctccgcttc
|
25261ctgagtccaa gtgattctcc tgcctcagcc tcccgagtag ctgggacgac aggcatgcgc
|
25321caccacgccc agccaatttt tgtattttta gtagagacgg ggtttcacca tgttggccaa
|
25381gatggtctca atctcttgac ctcctgatcc tcccgcctcg gcctcccaaa gtgctgggat
|
25441tacaggcgtg agccaccgcg cccagccctt tatttttact gtaagctgcc agtaaacagc
|
25501acacccacct gtctgctgac tgtcccatct ggaagttgtg taggtcctta ctgaatctta
|
25561ccttcttccc ttcccctacc cagaccccat cccagctggc acgtggaatc ctttcccttt
|
25621ctcctcatgt caatagacca gcaggcaaag agagcagtta ccatagtgga aggagaaacg
|
25681ggtcctagtc gtggtgagga ggtagggctg ctgcttaaca Raggccgaga gggacatgtc
|
25741tgatgctcag gtgatccact aggacatctc gcaatactcc catgcccagc tgtaactatg
|
25801atggccaagt ccaagaacca tagcctgata agagtctagg acccccacta tacatgccac
|
25861cagtagaagt gcctgatggg gagagggatg tctagaatga gtaggaggga atgatgacaa
|
25921agcacagcca aggaccaact gcagtggcag gtggcagcca cagattgagt taagtaggat
|
25981tcttgctgtg ttccctagtg gaagcatctc ccttgttgag acccactgag gttaaagttg
|
26041gagacatggg gagaaaacaa tgtccccgtg ttcatcacta gagtcatgat gggcaaggtc
|
26101acaactcatt tgacttcttg gctcccagat tcatatactc tgcctcttgg gggcacttca
|
26161ccataataca gccattggtt cagttgtatg ctgcatcctg agggacagca ctccatcccc
|
26221gcagtgccat gtccaaactg ctgccccgcc tcactctcaa gaggctgtcc cactactctg
|
26281tcaggcacca gcttctgaat gcagtggtaa gactctgtcc tgtgatcacg tctatggctg
|
26341attctctttt gccatactga gtcccctgat caaagcagtg ttatacagcc tggcgcgctg
|
26401gctcatgcct gtgatcccag cactctggga ggcagagggg gatggatcac tagaggtcag
|
26461gagttcaaga ccagcctggt caacatggtg aaaccctgtc tcctctacta aaaattcaaa
|
26521aattagctgg gtgtggcatg agcctgtaat cccagctact cggaaggctg aggcaggaga
|
26581atcacttgca cccaggaggt ggaggttgca gtgatccctg atggtgccgt tgcactccag
|
26641cctgagcgac aagtgtgaaa ctctatcgca aaaaaaaaaa gcaacgctta tgattgatca
|
26701cacactgtac tttctaacct gaaggggtct ggtaaaatca acttgtcttc tcaagggaca
|
26761gtaccaaact gggggctcag cactgacctc tgctggcatg tcggacattt aaaagtggta
|
26821gcagctagag cagtcttgaa gacatggagc cctcactgct ggggccgagc actgctgggt
|
26881tcaattctgc taccaaggct tctccatttc cgagcccatg gtgcaggcac tggggtgcct
|
26941aagaggaagt gcactaactg gacttctgct atgcaccttc tttagggggc attaaagcac
|
27001agttcaaaga ctctcacatt ttgagttaac ccccacaggc ctgtgtgccC CttctcCagt
|
27061caggtcatgt tgtcatttga tcctagttat tattctgaaa gggttcagga agggaggtgg
|
27121ggacagatct tgRaaagggc aaacattgcc ttgtatgcct catctgaggc ttccgcatag
|
27181tcttagggga ctgggaaccg tcttaagtga atctcacctt cttcccttcc cccagccagg
|
27241ccctagccct actggcatga ggaatcctat ctctttgtcc tcatgccagg agaccagcag
|
27301gcaaagagag cagttaccat actggaagga gaaatgggtc ctggtcatca gaaggaggta
|
27361ctcctcaagg gacagtacct gagggagaca cttccactag ggaacacagc aagaatccta
|
27421cttaactaaa tctacggctg ccgcctgctg ctacagttgg tccttggctg tactttgtag
|
27481tacaaggcga agtaggccac tgctgccagc ccaggaggtc aagggcattt acccagacat
|
27541cctcattccc agtttttggg tcccttatct tccctctcag gatctaatga ctcatctact
|
27601ggcactagga gtccaaaatg accagatggc agactcgcct aggctgagaa ttcttccttc
|
27661tctcaaattc tgccactttt accagcccag tctgcctctg ctgtaggaga tgagaggcta
|
27721aatgttggca gggaggcccc ctgattctga tcctgtgttt taaatcgata attagtcYga
|
27781ccctgttact ttctcccttc agtgcatcaa cgggaggctc ttagcaacag cctcccaact
|
27841ctaccttcct gatagataat attttcctca aagctctcaa atgctagaga cattgcacca
|
27901gctggYgtgt ccccatccac ctgtatctga tcccaggtca ccacaggtga aggtctgagc
|
27961aatcgaactg ctacagcagg ccaggtacca ggactctcaR cacgccactt aacaccaata
|
28021atgaggtcct catggccatt tggcctgcag tgagccaaca ccagaatccc atccattctg
|
28081ggacccctcc tgctactaac ggtcttcagt caggttcccc agaagcagat tatgcaaatg
|
28141tgttattgaa aaacggcttt cagatgaaac ctggaagaca gtgaaggccg aagctagggc
|
28201agggaagaag ccaggcacag acgtgggctt agcagaagtc tagcatcagc ctgatcccct
|
28261gggcagtact ggagcatgga tggcaccaca ggttaccatc ttgagacaga aggactggct
|
28321tctgtaccct gaatcagtaa gccattggtg ggccataagc cacccttagg ggaggacata
|
28381acctcacagg catttcctgg ctggacgacc ctgggcagct gagggcaact gcctgaaggg
|
28441cacaacggtg agccattgtc agctaacctc acagcagcag agacatgggg ccaacagcct
|
28501ataaagaggg tctgggcagg ctgtcaatac tctctactgt aatactgtat atgtggttta
|
28561ttttaaaaac ttttttagaa ggctttattt tattttattt tttgagaagg agtttcgccc
|
28621ttgttgccca ggctggagtg caatggcgcg atcttgactc accacaatct ctgcctcctg
|
28681ggttcaagga attctcctgc ctcagcctcc cgagtagctg ggattacagg cgtgtaccac
|
28741catgcccggc taattttttg tatttttagt ttcatcatgt tggcctggct agtcttcaac
|
28801tcctgacctc aggtgatccg cccacctcgg cctcccaaag tgctgggatt acaggcgtga
|
28861gccaccgcac ccggctgact ttattttttt agagcagttt taggttcaca gaaaaactga
|
28921gaggaaggta caaagatttc ccatatatcc cctgtgctca cacatgcatg gcctccctat
|
28981caccatcccc caccagagag gcacatttgt tacaatggat gaacgtatac actgaatata
|
29041tcatattcac ccaaagtctg tagctcacat catggttcac tttggctgtt gtacattcct
|
29101tggatctaga cacttttata atgacaggta cagtagtccc cctttatcct caggggctac
|
29161ttccaagatc cccagtggat gcccgaaacc gcagagagtg ccaaacttga ctgccatcag
|
29221tgggaatatg tttctattcg ccttccacca ccaccggttt aacgcctttt tcatcttagt
|
29281gctgctgccg taactttggc agtttgagat gcgacagcaa aatgagtaca aatttctttc
|
29341tccttcttca caatgtcatg gacagatgat tccttcttac catagatctt agcaacctcg
|
29401gtgtgtgatt ttttttcttt cttgttaaat caactttcac cttttcactt aaaggaagca
|
29461tttgacggct tctctttggc atatctgaat ttccagcatc acgactgtgc tttggggcca
|
29521ttgtttgttt atttatttat ttattttatt tatttttttg agacagagtc tcgctctgtt
|
29581gcccaggctg gagtgcagtg gcgtgatctc ggctcactgc aagctccgcc tcccaggttg
|
29641acgccattct cctgcctcag cctcccgagt agctgggact acaggcgccc accaccaagc
|
29701gcagctaatt tttttttttt tttgtatttt tagtagagat ggggtttcac tgtgttagcc
|
29761agggtgatct cgatctcctg acctcgtgat cctcccgcct cagcctccca aagtgccggg
|
29821attacaggca tgagtatttt atttatttat ttattttttc agacagagtc tcactctgtc
|
29881ggccaggctg gagtgcagtg gcaccatctc gctcactgca acctccgcct cccaggttca
|
29941agcaattctc tgcctcaaac tccggagtag ctagaattac aggtgcacac caccacgccc
|
30001ggctRatttt tgtattttta gtagagacaa ggtttcacca tcttggccag gctggtctta
|
30061aactcctgac ctcaggtgat ccacccacct cggcctccca aagtgctggg attataggcg
|
30121tgagccaccg tgcttggcct tggggccatt attaagtaaa ataagagtca cttgaacaca
|
30181aacactgtga tcctaacagt cgatttaatc accaagatgg ctataagtga ctaaggctgg
|
30241cggggtgggg agcacagaca gcagggacac cctggacaag gggataattc gtgtaccaag
|
30301caagacacag cggaaggcgc cagatttcat cgcactactc agaatggcat atcatttaaa
|
30361actcatcgat tgtttatttc tgtaattttt ccatttgata tttggacagc agttgactaa
|
30421gagtaactaa aacctggaaa gtgaaacagt ggataagggg gtgctcctgt acttctcaat
|
30481gtgagacatt tgcccttcat gttaattctg ccccattagY tctacacaaa tgaatagcag
|
30541gaaattgatt ttaaaccaca tggtggtaaa atgctttctt ttttctccct catttaacta
|
30601aagaagggct gggccctagg tgatgtcttc cttagcatct aagcagctgg catcacccca
|
30661ctgcttctgt gctccactct cccatgggac cctccctacc tttaatccct cctgtgctgg
|
30721aggccgggtc ttccttgcta gtggtagctc tttccatatt tttaatccat ggtccggatc
|
30781ctgctccact gcctttgctt tagagaaata aacatgaata ttgagtcact ggaaggaatg
|
30841acacacgcat ccctccccca ccagttggag taacgctggc ccacctagtg tatctctggt
|
30901ctaggtctcg aggacctgct gctcctccct cacctgtagt tgaagacctg cctcaggtca
|
30961gtaggtgata cgcagtaagg aaatgtccaa aggacacttc ttgttggatt acacagcaaa
|
31021catctaattg gctgcaaatc tttttttctt tttctttctt tttttttttg agacagagtc
|
31081tcgctctgtt gcccaggctg gagtgcagtg gcgcaatctt ggctcactgc aagctctgcc
|
31141acctgggttg acgccattct cctgcctcag cctcccaagt agctgggact acatgcgtgt
|
31201gccaccacac ccagctaatt tttgtatttt tagtagagac gaggtttcac catgttggcc
|
31261aggatggtct tgatctcttg accttgtgat ccgcccgcct tggcctccca aagtgctggg
|
31321attacatggc tacaaatctt aaagggggaa gagatgagga ggaataatcc cctttgtctt
|
31381ctcaaaaatg ttttcactgg ctcactacag ctccctcctt cctctttact gacccaaaat
|
31441gccaactatt atagtaactc ttttgggtta gacgaatcca gtgaataaac acctactaag
|
31501cattggaggt ccaagaggaa taagatatgc ctgagctaaa cctcatcacc cccggccttg
|
31561cttgcagagt ggtttgctgg cctcatctga ttattcaatg agtgctttca tttgtttatt
|
31621cactaaatat ttactgagca cctacaaaag tgcctggccc tggtagatga ggcctgaggg
|
31681aagctaaaac taataagaca aactccatgc cctagaggaa ttcatggtct catagggaga
|
31741aaatgtaaac acatcataaa attatagctt attaaatgct gcaatagagt actccgtaag
|
31801agtgtggggg cagagaggag ggggagaaac agctgctttc tagagccctc accttttcca
|
31861cttctctcat ctttctgggt tagggtctag cgggggttcc atgaggatca ggctaaatga
|
31921gcttagaaaa actaagcaga ctactgtatc agaactggat cacagtagac aggcgttttc
|
31981aacaaacata tattgagtat ccctgagtgc tttggacagg aagaggaatt atagacgaag
|
32041attgtaagtc gcagtaatag atgaggcaag gagcaccagt gaggacttaa ccctgaaaga
|
32101agtgtgagca catcttcctc ccagacaagg gggaataaag aaaggaagat gatcaggaga
|
32161gttctaagtg gaactcagca gccagagggg aagcYggagg aggtaacatc agagggtgcg
|
32221tttgcccact cagtaaagta ggaggcaggg cagccttgtg aaaataggaa tggaatagaa
|
32281agctcaagaa aacagccaaa agcaagggca attaggggag gtttcgaact ggcagatcta
|
32341cctcaactgg caatacagca agcatgcacc agaaaagata tcctagctag cagtggggtt
|
32401gggaactgat ttaatatcct aggctagcag tggggttgSg aactgattta ttatttaatt
|
32461ttttatatct attcatgtat ttatgcactt atttattttt gagataggct ctcgctctgt
|
32521cacagaggct agagtgcagt gatgtgatct aggctcactg cagctttgac ctcctgggct
|
32581caagtgatcc tcccacctca gcctcctgag tagctgggac tacaagcacg ccaccaccta
|
32641ggctaatttt tgtatttttt tttgttagag acagggtttc accatgttgc ccaggctggt
|
32701ctcaaactcc tgggctcaag cgatccatct gccttggcct cccaaagtgc tgagattaca
|
32761ggcgtgagcc actgcgccca gccaatattt tttaaaaatt ggaaatccct tgtaataagc
|
32821caagtgttgg gggaagaaaa gcaataaaag caatgacatg gactcaatat gaaacatcca
|
32881aagcatttga catgccttta aaataaaaaa atcagtactc acctcgtgct catttcaaac
|
32941tgtggatttc cttggtctaa aattttaaaa aacaaaaaac agcactctca aatttaagct
|
33001aatttgaatt gattttacat agtgattttt aaatacacat atatgcataa agagaatact
|
33061ataaaaatat ataaaggtgt gtaggtcttg atcatatttt cccaggaatt cagaaaacgc
|
33121tgctacagtc cctgggctca cgtggtcctg gcatcctccc caacgtctct accccatcct
|
33181gctgagtttc tggcatgcat tggttctggg tctgtccaag tttctactgt tagctccatt
|
33241aatactgaat taaggaataa acagtgctca aatgctcatt ttttccatgt gagcccaaat
|
33301tatgtgactt gatgagggaa aaaatcatga gtccctggga gagcgataag aatcacattc
|
33361tttactaaag tgttgtccca ggtatgagaa taacaccaga tctcaacctc cagaggcccc
|
33421ccactgcctc ccacagcata aaagccaaat tcctcggccc gatatttgag gccatctcaa
|
33481tctttttcct ttcaccctat acctgactct cccaggctag gctcagatcg tcactgaatg
|
33541tgctcacttc gaggcacctc tgtgattttc aaggttcctg ggcccacctt ttactaccga
|
33601tgtgactgcc acatgttgcc cagttgctag gatgggaccg tggccttgat ttctgccggg
|
33661actgaggctt tgccttgttt cccacccacc ctgctgcctg cccctgcact cttctggctg
|
33721gggcctgatc tttccccgca gtctcccttc acctctagat cacaggcagt catgccacag
|
33781ctgaggagct tgtcccaaac ctcagtgcct gcctccctcc tcggcttctt gtgctgctgt
|
33841gtctcaccca tcagtgaYgc tcttctcttc cctgcccaag ccctagctga ctccataaca
|
33901cctggataca atgtcctctt ctgtctggtt acctccgaga ggccctctct ctacatccct
|
33961cattggctcc cagtgtcatt cctctcaccc atggccctaa ggtcactgta ttctttggcc
|
34021agtgtacagg gttattatgc ttaacaatcc acaaaggttg aaaggtgttg taggatggtg
|
34081taaaaatgaa tctgggtggt aatgtttata tgtcagagct ttgtaaagtg ctcggcaggc
|
34141gtaaggtact gacagtcctg atattcctga tcttggaacc tgggacacca tcttctcaac
|
34201attgcccgga taccctcaag ggtatccaga cagcctgagt ttgcattctg ttcctggttc
|
34261agcccagggc cctggttccc gctcactcac catccactgt gggccctctc taaattctta
|
34321aagcccttgc catttgcatc actcacagag acatttcatc agagcctact tggtgcacca
|
34381ggctcaggag actcagttct gctgcggata agttatgtaa aattgaccct ctgcttgcac
|
34441atctgtaaaa ggaaggggct ggcacaacac ctctgggcct ttcagttcag tagtgttttc
|
34501tttttatcta aaccacgtgc tgggtcctgg ttttgcttct tatctagatt tttgcattcc
|
34561tgtcacaacc tataaagcac agttcaggcc ttaaggaggg cttgagaaat ctctttccga
|
34621attgtcaact gaataagtgt catatcttca taacaaactt gtcttttttt gcagggccag
|
34681gaaggcagca ggggagtcag ttaaaatata aattttagat taagcttaat attgttaaga
|
34741agtcaattct caccaaattg ttctagagat tttacataat cctaatcaaa atctcaataa
|
34801ggttttttga gaagttggca agcagattct aaaatatata tagaagtata aaggacacag
|
34861aataatcaaa acaactttaa aaaggaagaa caaaattata ggactctaac tacctcattt
|
34921taagacttat tagaaagcag cagtaaccaa gatagtgagg gactgatgtc aaggtagaca
|
34981aatagatcaa tggaaaagaa tcaggcatcc agaaatagat gcacttacat aaatcatcaa
|
35041ttggagaaag aatagtgttt ttaacaactg gcaatggaaa aactagaaca tcagtatgca
|
35101aaggactgaa ctttgatcca tacctcacac cacatacaaa tcaaaaacag aaacaaacaa
|
35161acaaacaaac aaatactcaa aatggatcag agacctaaat gtaaaactat aaaacttctg
|
35221gaagaaaaca cagggagaaa atctttatgg cttttagata acgatttctt aggcaggata
|
35281ccgaaaacat gatacataca gtttttaaaa ttaaatatta taagaattaa agtcttttgc
|
35341tcttcaaaag tcactcttaa gagaaaaaga tgccacacac tagaagaaaa tatttacaaa
|
35401gcattaaaag gacatatatc taggatatac ataaaaactc tcaaaagtca ataataagaa
|
35461aacaatgagc aaaagatttg aacagacact tcaccaaaga agagataaag atggcaaaga
|
35521agcacataaa gagatgctca accattagtt actagggaaa agcaaattaa aacctaatga
|
35581cataccacta tgcccctatt agaaatctga aaatttaaaa gactgacaat accaagtatt
|
35641ggtgaggaca tggcacaagt ggaactctca tacattacta tgggaatgga agatactata
|
35701atcactttgg aaactattta gaaatttcct aaaaaattaa acatacacct accatatggc
|
35761ctaaccatta cactcttagg tatttaccca agagaaatga aaacacatgt ccacacaaag
|
35821acttgtactt gcatgttcat agcagcatta ttcaaaatag ccccaaagca gaaacaaatc
|
35881ggatgttcat taacaagtaa atggataaag aaaacggggt ctagccaaac aatgaaatac
|
35941tactcagcaa caaccaaaat atgtactatt gtttacaaaa tccaaataga tgaatctcag
|
36001aataattatg cagaggagag aagccagacc aaaaaaaaaa gtacatagtg tattatctct
|
36061tatgaaattc tagaaaatgc aaactaacct atagtgacag aaaggagatt ggtggtcacc
|
36121tggggtgggt gagggagggg caggagaaag ggaatgcaaa gcagtgtgaa caaacctttg
|
36181gcggtgatag gcatgttcat tatccttact gtggtgatgc cttacagatg tatacagatg
|
36241tcaaaactta tcagattgta cactttaaat atgtgtggtt tatcgtgtca ttatacctca
|
36301gtaaaggagt tttaaaaatt gtagtaaaag gtctctacct agaaacctta ataagctaaa
|
36361atgtatgtcc ccaggactaa ccctagctat tctatagttc tggggtggaa cctagaaatc
|
36421tgcatttgta gcaagccctt caaataattt gaatgcaggt ggtccttaaa ccaccctttg
|
36481agaaacactg acctagtgag taaggatttc taaacaagct tgtgactaga atgttgtttc
|
36541tgcagggaac aagtgacttt ttctactaga gttgccatat cattctgtgt taagcctcta
|
36601ggacactcct actcaattac catgacatat atttaacata atattaatag ttgtaaaaca
|
36661aaagtaaacc atagtttttt tcccatctta tctgtataca aagtaaaatc aatgacataa
|
36721tattgttact agttcctggc agttacctac agtttaaatc aagaacttat gttgcttggt
|
36781ttttgtgaca gaaaactgat gtggtggctt tccagttaca ctgcttggtt taccttttcc
|
36841cttatcttat gatgcacacc cagctttgca cgttcctgag cagctgatga tcatagaaga
|
36901cctagaaaaa gtgtgagcca gttgcattcc tgctatctct aaagaaaaaa gttatctttt
|
36961catttttatg tgatttttct tacccaaaat gcaaaccact gccagtataa atgatggaag
|
37021atagactttc cacatgaaac tggcatttct tcaccctagt aacattacct gaggggaagg
|
37081tcagaactca attgataaag ctcgctgtgg attttcccac caaatatccc tgcaaacaaa
|
37141gtgaaaggat aaagcctgct taaagatgat ttgtaattgt tgaaaggagt acagtgtgtg
|
37201acatcagtga aaatggtgga gaaaaaaccc gtccccaaat tctcttcttt gtgaaagcat
|
37261ggaaaaaact ggccaaaaat ggttagaaaa tttattttca gaatatcgaa attttttttt
|
37321cctttttttt ttttttatta tactttaagt tctagggtac gtgtgcacaa catgcaggtt
|
37381tgttacatat gtatacatgt gccatgttgg tgtgctgcac ccattaactc atcatttgca
|
37441ttatgtatat cccctaatgc tatctatccc ttccccctcc ccccacccca ccacaggccc
|
37501tggtgtgtga tgttccctac cctgtgacca agtgttctca ttgttcagtt cccacctatg
|
37561agtgagaaca cacggtgttt ggttttctgt ccttgcgata gtttgctcag aatgatggtt
|
37621tccagcttca ccatgtccct acaaaggaca tgaactcatt gttttttatg gctgcatagt
|
37681attccatggt gtatatgtgc cacattttct taatccagtc tatcattgat ggacatttgg
|
37741gttggttcca agtctttgct attgtgaata gtgctgcaat aaacatacgt gtgcatgtat
|
37801ctttatagca gcatgattta taatcctttg ggtatatacc cagtaatggg atggctgggt
|
37861caaacgatat ttgtagttct agatctttga ggaatcgcca cactgtcttc cacaatggtt
|
37921gaactaattt acagtcccac caacagtgta aaagtgttcc tatttctcca catcctctcc
|
37981agcacctgtt gtttcctgac tttttaaaga ttgcctttct aactggtgtg agatgttatc
|
38041tcattgtggt tttgatttgc atttctctga tggccagtga tgatgagcat tttttcatgt
|
38101gtctgttggc tgcataaatg tcttcttttg agaagtgacc gttcatatct tttgcccact
|
38161ttttgatggg gttgattttt ttcttgtaaa tttgtttaag ttctttgtag attctggata
|
38221ttagcccttt gtcagatggg tagattgtaa acattttctc ccattctgta agttgcctgt
|
38281tcactctgat ggtagtttct tttgctgcgc agaaactctt tagtttaatt agatcccact
|
38341tgtcaatttt ggcttttgtt gccattgctt ttggtgtttt agtcatgaag tccttgccca
|
38401tgcctatggc ctgaatggta ttgcctaggt tttcttctag ggtttttatg gttttaggtc
|
38461taacatttaa gtctttaatc catcttgaat tcatttttgt ataaggtgta aggaagggat
|
38521ccagtttcag ctttctacat atggctagcc agttttccca gcactattta ttaaataggg
|
38581aatcctttcc ctatttcttg tttttgtcag gtttgtcaaa gatcagatgg ttgtagatgt
|
38641atgatattat ttctgagggc tctgttctgt tccattggtc tatatctctg tttttggtac
|
38701cagtaccatg ctgttttgat tactgtagcc ttgtagtata gtttgaagtc aggtagcgtg
|
38761atgcctccag ctttgttctt ttggcttagg attatcttga caatgcaagc tcttttttgg
|
38821ttccatatga actttaaagt agtttttttc caattctgtg aagaaagtca ttggtagctt
|
38881gatggggatg gcattgaatc tataaattac cttgggcagt atggccattt tcacgatatt
|
38941gattcttcct atccatgagc atggaatgtt cttccattgg tttgtgtcct cttttatttt
|
39001gttgagcagt ggtttgtagt tctccttgaa gaggtccttc acatcccttg taagttggat
|
39061tcctaggtat tttattctct ttgaagcaat tgtgaatggg agttcactca tgatttggct
|
39121ctctgtttgt ctgttattgg tgtataggaa tgcttgtaat ttttgcacat tgattttgta
|
39181tactgagact ttgctgaagt tgcttatcag cttaaggaga ttttgggctg agacgatggg
|
39241gttttctaaa tatacaatca tgtcatctgc aatttgacaa tttgactttc tcttttccta
|
39301attcaatacc ctttatttct ttctcctgcc tgattgccct ggccagaact tccaacacta
|
39361tgttgagtag gagtggtgag agagggcatc cctgtcttct gccaggtttc aaagggaata
|
39421cttccagttt ttgcccattc agtatgatat tggctgtggg tttgtcataa atagttctca
|
39481ttattttgag atacgtccca tcaataccta gtttattgag agtttttagc atgaagggct
|
39541gttgaatttt gttgaagacc tttactgcat ctattgagat aatcatgtgg tttttgtctt
|
39601cggagaacac tggaaattaa atgatggctt gcagcaatct ggagagcatt tattcaagga
|
39661aaatggctgt gtctcagtat gactaatgag ctttttaact tgccctattt ctatcctccc
|
39721cttccttggt ggtagcctta gaaatgaaca gcctgcaatg atagtgaaaa tcagcagtct
|
39781ggcagccatg ggaggggcag aacaggaatg ggggaactat ggagcctcat tcttagagaa
|
39841ttatcattat ttgatctgtc cacgggtttc taggaatacc tgacctgcaa gtctgtcttt
|
39901attaggcctg actcagaact tgcccaatgt gaaaagtctt ttccccaaag gcctttgtag
|
39961aaaatgatta caggcaattg tttaacttct tggttgctcg aggtattggc taacagtggg
|
40021gcaaacatgg gctaatcaga aggtttaaaa tgaaatgctc aggaataaga tgctcataga
|
40081gggttgtaaa ggctccaaaa tatttatgag actctagaag accatgcaca catttcctgt
|
40141gaacatgttc aggacagatc tgcgaaggcc ccacgatctt acctctggct gatcttgatg
|
40201atctgcacaa acagaaagtg aaagctaggc tagaactgtc aagtgccagg ctgagtgtga
|
40261aggtgtgccc taatgtgcac acagagcccc ttggcaaaga ctagaagact tactgctttc
|
40321aggtgtttaa agaaatctct gtcatgtcat tagtatttag atcactaagc taactgaaca
|
40381gaggcttcaa tggctgcaca taaatacaga cttcacagaa ttagtttaga aaagtcacta
|
40441taacaaacaa caataaacag caacaccaac aaacagtaga ggtgggaagg tccaatttcc
|
40501agagttgcta cattatgtta tttaaaatgt gcaattttaa cagaaaataa tgagacatgt
|
40561aaagaaataa gaaaatgcag tccataccca gggaaaaaga aaaaccagtc aatacaaact
|
40621gttcctaggc caggtgcagt ggctcatgcc tgtaatccca gcactttggg aggccaaggc
|
40681aggcagatca ccagaggtca ggagtttgag accagcctga ccaacatgtt gaaaccccat
|
40741ctctactaaa agaaaaatac aaatttagcc aggcatggtg gcgtgcacct gtaatcccag
|
40801ctactcggga ggctgaggca gaagaattgc ttgaacccag gaggcggagg ttgcagtgag
|
40861ctgagatcat gccattgcac tccagcctgg gctacagagc aagactctgt ctcaaaaaag
|
40921aaaaaaaaag aaaaaagaaa aaactgttcc tgaggaagcc aagatactga ctttactaga
|
40981ccaatacttt aactattttt acatgttcaa aaagttaaag gaaatcatat ataaagacta
|
41041aaggaaagca caagaacaaa tcctcattaa atagaaaata taaagatttg ttttaaagga
|
41101cgaaacagaa attctagatt tcaaaagtat aataattgaa tgagaaattc actagagtgg
|
41161ctggctcaat agcagatctg agcaggcaga agaaagaatt agagaactca gaaataggtc
|
41221aattgaatct atccagtctg aggaagagaa agaaagagga atgaaggaaa aatgaataga
|
41281gcctcagaga ctgtgagata ccttcaagca cgctaatgac gcataatggc agtctcagaa
|
41341ggagagaggg ataaatgggc taaaataata tttaaagaag caatggctga acatttccca
|
41401aatctgatga aaacattaat ctataccttc aagaaagtct ataaactcca agaaatataa
|
41461attcaaagag atcaagatcc acacctagag ataacataat caaactgtca acaaagacaa
|
41521tgaaattatc ttgaaagcag caagcacata gaaggactct tcaataagat taacagctga
|
41581tttctatcag aaatcacaga gttgagaagg caatgggatg acatattcaa agtgcttaaa
|
41641gaaaaagagg gtcaacaagg aattctatac ctaaagccaa tttatcttca acaaagatgc
|
41701caagaccatt caaagYgggg aaagaatagt cttttcaatc aatggttcta ggacaatgga
|
41761tatccacatg taaaaaaagg aacttgggcc cctaattcac atcatataca aaaattaact
|
41821cggaatgagt caaaggctta actgtaagag ttaaaactat aaactctttg caaagaacac
|
41881tatcaagaga gtaaaaagac aatgcacagt atgggaaaaa atacttgcaa ataatatatc
|
41941tgataaaagt ccagtatcca gaatatataa ataactctta caattcaacc ataaaatgac
|
42001aagccaatta aaaaacatac aaatgagtta actgacattt ctacaaagaa gatataccaa
|
42061tggccaatat gcatgttaaa agatgctcaa catcactagc catgagggaa atgtaaatca
|
42121aaatcacaat gagatactag tacatgccca ctaggatggc aatgataata ataataataa
|
42181taataatgtt attataatga acaatacaag tgttagtaag gaaatggaga aaattgaacc
|
42241caactattat attgctggtg tgaatgtgaa atggtggtac tgttttgaaa gatgatttgg
|
42301aagttcctca gaaagttaac aaaagttacc atatggtctg gcaattctac atatatacac
|
42361caaagaaaac tggaaataaa gattcataca aaaatctgta caaaaatatc tacagcagct
|
42421ttacttacag tatccaaaaa ggggaaaaaM cccaaatctt catcaactaa tgaatggata
|
42481aacaaagatg gtatatccat acaatggact gttactcagc cataaaaagg tatgaagtac
|
42541tgatagatac tacaacataa atgaaactta aaaaaatacg caaagtgaaa gaagctagac
|
42601agaaagggcc atatatgtga tgtgtagaga aaacatccaa tagagacagg aaatacatta
|
42661gtgattgcca ggggctgggt aaaggtgaga gatggagaat gattgctaat tggtacagaa
|
42721tttttttgtt gggagagtta tgaaaatatt ttggaagtat aattagaatt aggctgttaa
|
42781atactttaaa acaaaaaaca gctgggcgca gtggctcaca cctgtaatcc cagcactttg
|
42841ggaggccgag gcaggcagat cataaggtca ggagatcaag accatcctgc ccaacatggt
|
42901gacaccctgt ctctactaca aacacacaaa ttagccaggc gtgttggcgc gcctgtagtc
|
42961ccagctattc gggaggctga ggcaggagaa tcacttgaac ctgggaggca gaggttgcag
|
43021tgagcccaga tggtgccact gcactccagc ctgggcgaca agagcaaaaa ctccatctca
|
43081aaacaaaaca aaacaaaaaa caaaagtaag aagtaaaaaa atagaattag actggggatg
|
43141gttattgagc cttgtgaata atctaaaacc cactgaattg tatattttag acagtgaatt
|
43201tgatggcatg ttaattatat cttgatgttt taaaaaaagt agtacagtgt ctgaaaggta
|
43261gcattggcca tttgaatctc tgttaacatt ttcttgggtg gccatcagat ttttgattaa
|
43321aggtgacctt ggcaattaag tggtgggggg aacacaacca aaagggacaa accaacacaa
|
43381ccacacacaa tcacacaacc cctccacctc caccacagtg gaaatcaagc ataggtgctt
|
43441ccagggactg tgaaaatgtg gccacagttg ttttcccagc aaaccatttt ctttcacaat
|
43501atccccaatt tgcacatccc ccactgagct gaaatcagta taactcgaca gacRaaagtc
|
43561agcaggggta acctaccttt gatattattt tgttgttcca tcaataattt acttatttct
|
43621gaaaaccaac agtctctgat ttcttttgaa gctgcctgca atcacacata agaaaacact
|
43681ataagactac catgagtatt aattgcagag tttttattct cccagtgacc gttagactaa
|
43741tgagatagaa aacacttgtc aagtcatggg aacacaataa ggaaagagta gaggagaccc
|
43801atggggaagg catgagcgtt acctgcagga tgtatttctc aagtccattt cgactggcaa
|
43861tctcaaactt tctatggctc ccccttccaa gctggcgaat tgaaagtgtc atcagctatt
|
43921ataaagaggg aagagaaatg ttctatacca tcgttttctg attttaaaat agtccctgtc
|
43981aatcactcta atcctttcta tccttgacag ctctcttctt tcatcttcct ttcaagtttt
|
44041tgctttcctc tcttaatgac tccaagacag cataaaacac aatctggtac agtgtcttct
|
44101gtctcatctg tttcagaagg taacacagac tgttaacttt ctactgtatc tttatgcagg
|
44161aggcgctgca gccctcaacc tttcagtgaa gagatcattt ctccttcaac Rtgtatttta
|
44221caactttcta cgtaatagta actgaataag gatctattca gaaacataaa taacaaggcc
|
44281aggtatggtg gctcatgcct ctgtaatcag tcctgtaatt ccagcacttt gggaggccta
|
44341ggtgggcgga tcacctgagg tcaggagttc gagaccagcc tgaccaacat ggtgaaaccc
|
44401tgtctctact aaaaatacaa aattagctgg gcatgctggt gcgtgcctgt aatcccagct
|
44461acctgggagg ctgaggcaga attgcttgaa cccgggaggt ggaggttgca gttagccaag
|
44521atcatgccat tgcactccag cctgggcaac aagagcaaaa ctctgtcgaa agaaaagaaa
|
44581gaaagaaaga caagaaagaa agacagaaag aaagaaagga aggaaggaag gaaggaagga
|
44641aggaaggaag gaaggaagga aggaaggaag gaagggaggg agggagggag gaaggaaggg
|
44701agggaggaag gaaggaagga aggggagaaa gaaaacaaag gctactatga acaaattaac
|
44761agctttaatc acaaSagcat aaatatatat gggtgtggct cctgtatgtg ggtgtgtgtg
|
44821tttcatagcc tgagagctaa ctggctatga aacagtttct aaacaggtga gaaaacaatg
|
44881cttggtgtgg gcctgggtgc cttagacccc aaggtcagga caatgcctgc acttagacac
|
44941aaagatacac cgttgagaag gRcaagtcta agatgaaatc cagcccatgt tctcatcact
|
45001aagtctttca actctctttt acctctttgc ctggaagaaa gagggtactt ttactaatta
|
45061gtttgtccag actggctgcc atatagtctt ttttctctag tacaaaggca ctcctatgcc
|
45121agccctggcc cataagctct gaccctggag tcagacagac ccggctatgg attctagccc
|
45181tgtggtgtgg tatttggcaa gttaacttca cctctctaca ctgcagcttc ctcatctgta
|
45241aaataaggaa aacgatctct ctcttttctg catagggcga ctcccagatg caataggact
|
45301ccctttacct tcatggYctt cttgaagctg taatgaggag ataatccctg gtccccaggc
|
45361tccattcgta tcttacagaa cactattccc ctttcaaata ggtagatttg cctctggctg
|
45421ggtttaaatc gaatcaaatc cttcatttta taacgatcct tgtgaattgt ccagacgctg
|
45481aaagggccgt gcagcaacag cttgcctagt tttccaatat cgtccttttg gaaacacaca
|
45541tacaggaaaa gaagctgtaa aattacttga cagagaaaga agcctttgtg gcctgttttc
|
45601aaattttata aagcatgctt ctttgaggtt tacaattcta aaagtgctat tcaggctggt
|
45661ctgtcactaa atcaaaacga caattttttg agcttcactg agcgtggtgc cRtttagtta
|
45721tataaggaaa tcaattcagc tatgaaaggt aatgctatac ataaagaatg ttagaaatgc
|
45781ttgagctaga gatacgggga ctgtgatatt tttgactcaa ttttaactag cagaattcaa
|
45841tttcctctgt gctatgtttg atacatgaca gtctccttca aagggacaag aaattaacat
|
45901ttcaattatg tccagtagag atagaatttt ggctgcattg Yggacccatg agcatctgtg
|
45961tgttccatct gcatcctaac ttctgcttca ggtatatgag gacctgagaa aatgaagctt
|
46021gttctgaaaa gagaaagttt actgtgatct aatcttcaca acattgtaat ggaaatagta
|
46081actgcattca actctgagtt tttcagagtg agtcaacagt gccaagataa taccaaatga
|
46141cagattttta agaagtctgt ttgactctag gcataaactg tgatgcccct gtctccacca
|
46201gcaaggctgc ctttgtcata tgtctggttg aaagtccaaa tgagatgacc ctgccttctc
|
46261tgagctctct tcaaaagaca gtggaccaag atgagctggg agcgaggcat tttatctggt
|
46321atttttcaaa acttcgattg cttaaagcag ataagaattc atttccctga ataaaaacac
|
46381caaaaggaac aaattatttg aaggggacca agacaaagaa atctccctaa gtgacctcta
|
46441gctgagatca atccctatga tttctgagtt aatactggaa atatgtactt cattcataat
|
46501tgattgggca tttttataaK ttattgttta tatgttgggc aaactctagg tatctttttt
|
46561aaaaaggaat tgactttact tctgaaacat taaaagaaaa acttcaagag caataaactc
|
46621tagtcatttc tatggtgtct atggcgttat ttcctatgtt aattttctat tttcttcttt
|
46681ggaaaattta catatgtaga ctgtggtgaa taaaaccctc aaactcccag ccacgaggcc
|
46741ttctttccta aaagccaatg ctcctgttct gtgttaacag ttcaccacat tccaaaacag
|
46801aagggtggat aggtccatga ggaccctgga gaattttttc actctatctg catccatcaa
|
46861ggacccactc aaatgtaatc actacagacc ttagtgactg ctttttcctt taaatccatt
|
46921caattcataa tcaatatcga cataaatagt gcaggaaata tgttttagta aaggcaactg
|
46981gtagaagtag atacttaata tttgccacat aaacaaatgt tatcagcaca ggttgagcat
|
47041ccataattta aaaaatctga aatcctccaa aatctggaac tttctgagaa ccagtatgac
|
47101actggaggtg aaaaattcca tacctgacca catgtgatgg gtggcagtca aaacacagtc
|
47161aaaattttgc ttcaYgcaca aaattatttt ttatttttta tttttttgag acggagtctt
|
47221actctgttgc caaggctgca gtagagtggc acgaccttgg ctcaccgcaa cctctgtctc
|
47281ctgagttcaa gggactctcc tgcctcatcc tcccgagtag cttggattac aggcgtgcat
|
47341taccatgccc ggctaatttt tgtattttta gtagagccag ggtttcagca tgttggccag
|
47401gctggtctcg aactcctgac ctctggtgat ctgcccacct cagcctccca aagtgctggg
|
47461attacaggca taagccactg ctcccggcct tcatgcacta aattatttaa aatatgtaaa
|
47521attaccttca gtctatgtgt ataaggtgtc atgaaacata aatgaatttc gtgtttacac
|
47581ttgggttcca tctgcaacat aactcagtac gtatgcaaat actccaatcc tcccctaaaa
|
47641aaaaaaaaac tccaaaacac ttttggcctc aagcattttg gctaagggat attcaaactt
|
47701gtagtttcta tcttacaatg tattcactct ctacctcatt ttaaacattc gacgcatctt
|
47761acagaaatat atacagtata gacagataga aaataaccga gggaattaag gtgaagaaaa
|
47821aataaagaag ttgggagctt ggcgcctgcc tgtagtcgca actacttggg aggctgaggc
|
47881aggaggatca cttgagtcca ggagtttgag gccagcctgg gcaacatagg gagatcacca
|
47941tccctaaata taaagacaat aaatcagatg aactgttcca gaaggtgtag aagataaaag
|
48001aaaagatgaa gaggttatat gtaaaatgca tataataaag ccatKtaaac ttgatgtaaa
|
48061cttggctctg actttctaat agcaatacag agggaaacat ggtgagtggt acgatttatt
|
48121atgtctgaag acatacacaa accggttgtt caggaaaagc acagctattc ctactaagac
|
48181ataagaaaca tttctcccag tgatatgttg tcactgagca acatcctcaa ccacgcccta
|
48241tgatagaaag aggaacatgt tttaggtaaa gctgcttgta agaacacatt tggtcagtgt
|
48301ggaggctcag ctgtcaaagt aattctagaa gaggctagga tgatagggga agggggaata
|
48361agtcgaggtg tacactctct aatgacttgt gaagatgggg tgacgtgagt taaggcatcc
|
48421acaaggctat tgtagaggaa acagccccaa ccagaaatgc tgaagaggca gcctcaggca
|
48481gcaaggtttg tgctttatta cctctgaact ttcctcatca ccccatccac agccatgctg
|
48541ctgcaccttc ataggcaagt aatcagagga tgtgaatcca gagaggtacc agcagctgac
|
48601catagggccc ccagcataaa aacaatgtgc cagggKtggg ggttggcaat gtgatctctc
|
48661cctgaactga agaaaacagg aggaagtgRt gaccagcagg agaYggggct gtgagatgct
|
48721ttaggggaaa gcaggcagtg gaataaacga gaaggaaaca gaactatgaa gaaggtgagt
|
48781cattagaaat tatgaggaag aggaagaaac tgacggaagg gaaaaaaaca gtcagtaggt
|
48841ggtaagagSR ggggcgagca ggcatgtggg tgcacttgac atatacaggc gggtcacaca
|
48901ggtaagaacc ccggctccct ccccaggccc aggccccaga ggtgctgtgg atcctgggtt
|
48961tgctcagttc ccatctccgc gaacttggct ttgccatcgt gacttcttga gaagctgcag
|
49021gtcagctttc cagtaagccc attattactg gaagtgactc ggggggagtc gctgggtctt
|
49081tcaagtctgg cagaaacata tgggcacata tcctctgggt catgttgcac aaatgttctc
|
49141aggaccacac atatgacggt attgcccatc tccacgccca aggtccgatc tccagcgggt
|
49201gagcacatgc cctacacggt gctgaccaag ggcaggcaca cacactgttc actgtgctgt
|
49261gtggagctgc tccgcctcca acaggaagct gcagggacat tccctgagca ggagcaagaa
|
49321tgaccttttc cgtcacgtgt accttttctt tccaactaga ctgtagttga tctcaaggtc
|
49381ggagaccacg ttgcacaacc tctttcagat acgtgttcac cagtatttat ttatttattg
|
49441gcattcccta gtatttattt atttattggc atttagtggt gcttgggagt aggggacagg
|
49501aaacaaaata ctcatcactg tgagggaata ttgatttatc caaggagttc attcagcgac
|
49561gcccctgtac tgggttgaat agtgttcccc caaaaactca tgtctatgag accctcaaaa
|
49621tatgatctta ttcggaaaga gggtctttgc agatacaatt ggttaagatg gggttgccct
|
49681gggttaggat gggtccaaat ccaatgactg gtatccttat aaaaaaagaa aacaaagaaa
|
49741tggagacgca cgctgaggga acagccatgc aaaggcagag gcagaaattg gagtggcaca
|
49801gctgtcagcc aaggaactcc aagaattgcc ggcagtcacc agaagctcag acgaggtaag
|
49861gaaggattct tcctgagagc cctcagaggg aacgtgggcc tgctctcacc ttgcctttgg
|
49921acgtctagcc Ktcaaaactg tgagggaata aatttctgtt gttttaagtc acgtactttg
|
49981tggttccttg cgacatcagc cctaggaaac gaatatactt ccaactgttt tccaccagta
|
50041acaaagaagt gtggccatgt cacacggtgt gtggaagaac ctgatggttg tgaactcaga
|
50101gatggaacat agcggctacc tcaaatgagc gagcgataag ttagatggcc tcctctgtac
|
50161aagaagtgat agcaaaatca attagtaaat gctaccactt tcacacctgg gcattctgca
|
50221ggtaagagcc ccgatacaag gatttcaaat gtgactacat tggccaaatg aagagtctgg
|
50281ctgagagagt gaatctaggg aagctggcct cagcaagagc ttcttttggg tgcccgtgtt
|
50341tccattccag gtagtaagag ttaatatgac tgtcacaaac ttactgcaca aagaagcagg
|
50401aaacatctgt ataaatgcgt ccacacagag cctgagtcca gaaatgaaaa gcagaagctg
|
50461tgggagcctg tgattacaat agtcaggggc aaagaggtat cttcctttcc agcttgagca
|
50521ggtccccata taacgtacca ctagggctgt ttattcggca tctgttgggc gccaggcaca
|
50581gtgcttggtg ccttacccat catttaattc tcacttactc ccggcaaccg cctgtaatat
|
50641aggtattgtg ggggggtggg gggggtgggg gggtggggaa tgaagaagat actttgcctg
|
50701ggtcactagg attatttact tagccctatc tctgcagcta acactgtggt aaggaaagag
|
50761gaaactgaaa tagaaataaa atcctggccc tagctcacaa tgaacttaca atacaagtac
|
50821atcctttagt ggtttatata aatttgttcc aaaaaggaag actgtttcat tcaatcttta
|
50881caagtcaact ttggaactta tccctggcaa gtcagaattt aaatgcatct ctaatatgca
|
50941ttggatttga aaaaaaaaaa aacttttgtt ttttttttgc aaatagatag aagtaaatta
|
51001taactcagtg ttccacaaaa caaacttgtt tggaaaagaa ttttaaactt ctgtgattaa
|
51061attagaccca ggactaattg agtacacaga aaaacaagaa aatataaata tcagaaggga
|
51121tttttttcta gttgctttct agttgtttaa ttgtgataat ttaattatca cattcaattt
|
51181ctttccttta taaaaccagg ttaatattaa atttcaagca gagaaactaa gaggttaaac
|
51241tggactcagc catgcatata gctgtaattt attacaggtg atcataaaca cctgtaataa
|
51301aactctacaa aatggagaca aagaatctca gaatcatttg agctgagtta gaggcagttg
|
51361tcagtcaatt ctaatcagaa acagataaag agtggaatag caccctgata gggaatgaac
|
51421aagaaatagt ccaaggtgac agccatgtaa tcttgagtga gttaactctt ctttccatgg
|
51481atcttctttt gaatcagaag gttgaaaatN ccaatatcta ctcctNcata attcaacagg
|
51541attatacaaa actgtcagga gaaattagct gatgtattag atgtaaaagt aagttaagtc
|
51601ttagtagaaa aggtaccaaa aagcatctgg cagaggcaca attctgagga cacatggtca
|
51661aaaaaggtcc tttgcttttt gcgtgtaaaa tctccaaatt ctgtaagctg gttcatccta
|
51721tttgcatgca aactggctgg gaatgaaatt agggcagRat gttatttgct catgttttaa
|
51781ccattctttt ctcacagcct cctcctccta tgttatttac actgtttcct gccctgtgta
|
51841ttgtttccag gacattcatt agattcaggg aaatgaaatt taatagggat gtctaatacg
|
51901taattcaaga tttaaaaagg aacagaaaga tgccctggat tgacctaaca aattgttccc
|
51961ttgactttcc tcagScgaag aaagaagaat tattaccaag aaaatgatcc ttatacacac
|
52021cctaacccta ctctgcagtt tatgcatatc ctcttgaatc atgcatcagt tgtcatcaga
|
52081gacaccttgg agtcccaggg gacagtaaca gcatcatggc tgggatcaca gcaaacccca
|
52141tggggctaag tttctgagat ccaggcccaa gaaataccag cgtgggaagt aaaaataact
|
52201catttttcgg accttaataa ctttcatggt ttgatttatg acaaggaaag aaaagtcatt
|
52261tcctctacca agacctcaat acatggtatg ttcaaaacca aataaaaatg aaaagaaaaa
|
52321aaaagagaag gaaaaagtat aatataatca caagtgacaa aaacgcagaa gagggggtca
|
52381cagagatgtg atgtaagaaa aacttggccg ggcacgatgg ctctcacctg taatcccagc
|
52441actttgggag gcggagatgg gtggatcacg aggtcaggag ttcgagacca gcctgaccaa
|
52501catggagaag ccccgtctct actaaaaata caaaaaaaaa aaaaaattag caaggtgtgg
|
52561tggcaagtgc ctgtagtccc agctactcag gaggctggga caggagaatc gcttgaacct
|
52621ggcgggcaga ggttgcagtg agctgagatc atgccattac actccagcct gggcgacaga
|
52681gcaagactct gtctcaaaaa caaacaaaca aaaagaagaa gaacccaacc tgccattgct
|
52741ggtttgtgct ttattacctc tgctcataga agccatgagc catggagcgt gggtggcctt
|
52801tttaagctgg aaaattccag gagacagatg ctagactcca aaaaggaaag gaaacacctt
|
52861gattttagcc catgagactg tgttgaactt ctgaccttgg aacttcaaaa taataataat
|
52921aatgaatttg tgctgctcta agccaccaag cttatggtaa tttattatga cagtgaaata
|
52981aaacaaacac atctgaataa aaatctagag tacttcaaag taaaaaacaa aacaagtcga
|
53041atattaacta tgctccagtc tcaaagagat catacagtta taggggatgt tttgcctgga
|
53101atgcctggga ccagcctgct ccggattaac actgacgctg gagctcaact ccccagcatt
|
53161ggcctctaac tgcatctctt gggttttctt tagactattt ggattaatgc atgtacacta
|
53221tatacttttg gggcctcttc tgggatctgt gatataaaat tggggcaaga atataggacc
|
53281tgtttccaaa atacttttct tagagaaact ctgaaacaag aagacaaatc ttttactatt
|
53341ttaatagtgc catgagttag aaaataaatt gctcctccag gacttttcct ctgcccatat
|
53401atgttctggc ccttgacttt ctggtttgtc cagacagtgg gtcagtccca cattcagaac
|
53461cctgaggaat aaatYcaaga ttcctgaaga tgccaaggga cagcttggaa tcttgtagtg
|
53521cgggtttact gagcaattta ggcgactgtc ctcagagtcc aattccttta ccatagacga
|
53581tctctctgac tttgccagag catttcctca ctgtgtagta ttgcacctgc cttttgtgtg
|
53641agatgctcta acactactat ggaacatacc ggacattcag tcactgctgc taggtccaca
|
53701gccaactcac aggacttgat caaatcctct atcactgcca aagcttgttg tagttcagtt
|
53761gagaatgctg aatctttggt tctctttggc ccatcctgtg gaaaacaaat gccttgttgg
|
53821aaatcaaaag tataccatct gcaaagtgaa gaaggaaaac aggacagaga tgaggagcca
|
53881gggatccagc caaccctgac tgagaagggt ggatattgat ctgtctccct gctcccaaag
|
53941catggtggct aaagatgctt actgatttag gtatacggca tagagacaag caaaatcatc
|
54001tacctctgtg cattgtacta gtgacgaatg aagttcataa atcatggaaa ttatattcct
|
54061gctacataag aaacatatag aattcagcta tatagctgaa ttctatatgt ttcttatgtg
|
54121tatatatatt atataaatat ttatatagta tattaaatat ttatatatta atatataatt
|
54181atatgtttat atattaatta tatatattaa atatttatat attatatatt atataaaata
|
54241taagtatata tattatatat atatatatat atatatatat attttttttt tttttttttt
|
54301tttttttttt tttttttgag agegagagag agtttcactc tgtcacccag gctggagtgc
|
54361agaggcacga tctcggctcg ctgcaacctc tgcctcctgg attcaagcaa ttctcctgtc
|
54421tcagcctccc gagtagctgg gattacaggt gtgcgccacc atgcctggct aatttttgta
|
54481tttttagtag agacggagtt tcgccatgtt gaccaggctg ttctcaaact cctaacctca
|
54541ggtgatccac ccaccttggc ctcctaaagt gctgggatta caggcgtaag ccactgtgcc
|
54601tggccagaat ttagcttttt taaagcatgg aaaaacctag ctccttttaa ataggcttct
|
54661ctctctttta tacccctatt ccctggggct tactgaaaaa aaaaatacca tatggccggg
|
54721cgggtggctc atgcctgtaa tcccagcact ttgggaggct gagacaggca gagcacttga
|
54781ggtcaggagt ttgagcccag cctggctaac atggtgaaac cccgtctcta ctaaaaatac
|
54841aaaaattagc ttagtgtggt ggtgggcgcc tgtaatccca gctacttggg aggttgaggc
|
54901aggagaacag cttgaaccca ggaggcggag gttgcagtga gcccagattg tgtcattgca
|
54961ctccagcctg ggtaacaaga gtgaaacccc gtctcaaaaa aaaaaaaaaa aaaaaaaaaa
|
55021aaagtagctg ggtgtggtgg tgtgtgcctg taatcccagc tactcaggag gctgaggcag
|
55081gaggattgct tgaacacggg aggtggagtt tgcagtgagc caagattgcg ccactgcact
|
55141ccagcctggg caacaaagtg agaccttgtc tcacaaaaaa agaaaaaaga aaaagaaaaa
|
55201gaatacaatc tgagtatcat attcctatat ttaatgtgga agccttattc ctgtgggaaa
|
55261aattatactt aaaatcatcc cagaggagga catttgtaaa ctcctataga gacaaagaac
|
55321tccatagagg ctgctaagtg gaaatttact aatgatttac atgtaaaagc tataacatca
|
55381tatttccaca ctgaatctcc cccaactctg tccttccttc ctccacttgt ccctggccct
|
55441ccccacattg caccaccatt aaagatgcca aagagataag ccagcgctct gcacctcccg
|
55501aacataaaga ctcagcattc agcRgaaaag cagtaactaa ttaaagagac caatgttcca
|
55561attacaacca cagtgacatt taggatgtga ttggggtgat tgtttcagct ctaaaggctt
|
55621ttgcatgggc ttgaggtatt ttatctccct gctacctaca tgctgtattt atctgttacc
|
55681tggtaaatac acataaaaaa attttggttt attcaatgta tttttttaac atctcaagtt
|
55741ctgcagtgaa gaacagctag cccctttgct gctccgcatc tggccctgac tctttttgtc
|
55801ctctacagca caatgtagtc acagggttta atattttctt aatctatgcg gaagcactgg
|
55861gtatttgcat ctttggatga gagacatgag tgacagggct gatgaatgga atagatcgtg
|
55921ctgctgcctc tgaaaaacgt atcatggatt cgtagcttct cattcataat aaagaagctt
|
55981cgcttcctgg taaaagaaaa cagactctca cctgaattta ttttaacaac atcaataagg
|
56041gattaagagt tcttggcagg gcgcagtggc tcacgcctgt aatcccagca ctttgggagg
|
56101ccgagggggg gagtggatca cgaggtcacg agatcgagac cagcctgacc aacgtggtga
|
56161aaccccatct ctactaaaaa caaaaattag ccgggcgtgg tggcgggtgc ctgtaatccc
|
56221agctactcag gaggctgagg caggataata gcttgaaccc gggaggcgga gttgcagtga
|
56281gccgaaactg cgccattgca ctccagtctg ggtgacagag cgagactctg tctcaaaaaa
|
56341ataaaaaaat aagaaataat ttttttttaa agttcttata ccaggcatct tcctccttac
|
56401caaacactga atgctcagtt tcctttcaga tcctcacctc ttcccatccc ccttccttcc
|
56461gctaaccctc cttcacaaaa cacgaggtgg ctagggtttt gaactgtata atgtagggtt
|
56521cagaaaaatc ctttaaaaca ttattaaact cctctaacta gggctagctc ctcttgctcc
|
56581aggctgtaaa aatatgacct gtgtcctgag ctgcttctgt tttcaacagg tccttgtcat
|
56641ccattctgag cagaaagggc atgcaaatga ctgccccata agacatgtct caagtgtttc
|
56701ttgctaaaac cagaatattc tataggaaag ggaagagaaa ccgcactgct ataMcacaga
|
56761tttcttccta acctggtgtg gtcatggtca ccatttattc taagggaact ttggcagact
|
56821cttagagttc acacacacgc acacacacac acagaggaga acaaggcata acatatagaa
|
56881attagatata ctaagaggta caaagaagaa aacataatcc taccattcag gaaagccaca
|
56941gcagacattt tatcatatct atttacttcc agtcttttat gtatgcattt tacgtatttg
|
57001cttaattttg ttcccattaa aatttttttg gctgggtgca gtggctcacg cctgtaatac
|
57061cagcactttg ggaggccgag gcaggtggat catctgaggt caggagttca agaccagcct
|
57121ggccaacatg gcgaaacccc gtctctacta aaaataaaaa aattagctgt gcatggtggc
|
57181gggcacctgt aatcccagct acttgggagg ctgaggcagg agaatcgctt gaacccggga
|
57241ggcagaggtt gcagtgagcc aagattgcac cattgcactc cagcctgtgc aatggagtga
|
57301gactttgtct aaaaaaaaaa aaattatgtg gaaggaagaa aatatattac cacttccatt
|
57361tgggctgcaa atccctactt taaaattgcc tttaattttt ttgttttttt tcttgactgt
|
57421gagttatagg atacatacta ttttagaaaa tctagataat aaagaccacc aaRtaaaatt
|
57481gctataaatc ctccgaMcca tagacaaaca ccattaatag ttagttatat aaaatgtaat
|
57541atttaatatt gagtacctta gccgagcctc ctagttcacc tgggtctatc tccatatctt
|
57601caggagactc gaRatccagc agaccctgca ttaacccaaa agtcttgttg aaaattaaaa
|
57661tgtacattgc catcaaaatg tagattgtca acaaaatcta ctgtgcaaac tatctgccac
|
57721caatgctaag ctgactgaga acgtgtgtaa atgtgtaaga gggaaagaat aaatgatgta
|
57781tttggcacag ggtcctttcc acaaacctag aatcatattg tacacactat tttgtagact
|
57841actttttctc attcaaccat acctcatgaa tattttccca tgatattatg tttttctaaa
|
57901atatgggctt tgattgtggt agagtgttat atcttacaga taaaccattt ttctcattca
|
57961gcaatatctc atgaatattt tcccatgata ttatgttttt ctaaaatatg ggctttgatt
|
58021gtRgtagagt gttatatctt agagataaac catttttctc attcaacaat atctcatgaa
|
58081tattttccca tgatattata tttttttaaa acatgggctt tggttgtggt agagtgttat
|
58141atcttataga taaaccataa tcgaattata gtccccctta tcattaaaca tttaggttca
|
58201acaatatttt ttactataat aatgataata acttttgtgc atttttctta aagctaaatt
|
58261cctagagtgg aattgtaaat gttaagagtt ttgaggcata tttccaagtt cttcagagaa
|
58321ggactgtctt cctgccagct gtataggaaa gcctgtctca ccagccccta gcctacaagg
|
58381ggtagtacca tttaatcaaa aatctttacc aattgaatga aaagagaaat cctacctcac
|
58441tgttgtttta atttgacttc cttagataac tagaggtgta gaactttttt aaaaaaacgt
|
58501ttgctactag tgtttattct tttgcaaatt gctatgtcct ttgcgcatct ttttattata
|
58561atttccaaga gcacatgatt cattaagcat actgatcatc tgttacatat tttgttcaca
|
58621ttttccccaa tgtttcatga gtctgtcttt aatggtataa gctatcactc atcaccctct
|
58681ccccaagatc ccatgatcct ttctaaagca tgaggcaatc agtccaacat tcatgctctt
|
58741tcaagccagc acatgtgtgc gagatgcaaa ataagctctg cccctgggga tagagaaggt
|
58801cctagatagg attacaaggt Ygttcctttc tttgcaggca cgtaatggcc tgagctggtt
|
58861tcacaggcac cagcaagctt agctgtgggg acactgctct ggtctgcctt gggtagctcc
|
58921cacggctcct cacagacccc ccgcaaaata ttttgtagta attctatctc ttgtttcttc
|
58981agtgaaaggc agctaacaaa accttctaag tccttttaac ctgtattatc tcatttaatg
|
59041ctcccaacaa gcataccagg aaagtactat tattatctta tttctatagg tgagaaatct
|
59101gaggctgaga gaggttaagt aacttgcctg agttcacgca gcctggaagg gtcagagcct
|
59161ggattcagac ccaggttgtt aaactctcga gtctgtgttt ccaatgacga tgccccacag
|
59221ccctctgcgt ctggtaccga acctagctcc tatgtaaatg tcacctctgt gggaaagctg
|
59281gaacctaggc tgagggagga aggaccatca ctttcgtcct gctcatgcct cactgggccc
|
59341agaggttgga cttctacaat aggaatgaca gtgacaatgg gacatgcaga ggagcatgag
|
59401gccctgagtg agtgctgggt caaacatgct ctgaggtgct gctcgctgaa agaagcagat
|
59461cattatcctc atttctatgg tggtgtgaca gtctcaatgt ctaagataac agctacacat
|
59521catgcagagc ttcctgggct gtgccaagcc ctccgcatgt gctaatcatc tgcttcataa
|
59581cgatcttatg gaggaggttc tagtaccctc attttacata gaggaaaact aaggcccaag
|
59641aggKcaaggt ctcataactg acaaatggca gagtacaccg aggctgaaac tgctaatgga
|
59701aagcttgaaa ggagtaactt tgaaaaaatg tttttaaaat tatttttaca gatgaggtct
|
59761tgctatgttg cccaggctag tcttgaactc ctggactgaa gggatgcctc ctgcctccac
|
59821ctcctgagta gctgctggga ctacaggtgt gtgttatcat gtctggcctg aaaggggtaa
|
59881ctttttctga ggggagactg ttgggcaatg agcttaacct tcctgagcct cagtttcttc
|
59941acagtccaga gcatggctgg tatgtctgat tgtggagatt aaataagaaa tactgtaatc
|
60001ccagcacttt gggaggctga ggtgggcaga tcacgaggtc aggagttcaa gaccagcctg
|
60061gccaacatgg tgaaaccccg tctctactaa aaatacaaaa attagccagg catggcggcg
|
60121cgtgcctgta atctcagcta cttgggaggc tgaggcagga gaattgcttg aacctgggag
|
60181gcagaggttg cagtgaactg agatcgcgcc attgcactcc agcctaggca gagtctcact
|
60241ctgtctcaaa aaaaaagaaa gaaagaaaga aaaaagaaat acacgtgggg aagtacccag
|
60301taaacagtag gtgcttgttt ttgtttttgt ttttgttttt tattaagaaa tagtggccac
|
60361tgggcaagag ctacctaaat gccttataga ggttaattca acagacaact tatcgtggtg
|
60421gcccaaacct ttctctcaag ctcacaccta gaaaaccagc catgataggc cctcatatcc
|
60481tgtttggagt gtctgagaat gcttgcctgc agatgtgcta gtgtcaatga cttatcacta
|
60541aggaggggta aaggtcagag agagagagag aaaaccactt aggggttcag ggttcagata
|
60601tagcaaagtt cattctgtta ggctgctctc agggtaagat cctaaatcta agaatggagg
|
60661tcagtgctgc aaaaggatag aagacttcag ttttgtcttc tcccttccac aagttaaaat
|
60721gcccataaaa cagtaacttt ggggaaaatc acactctcgc tcccaaagag ctctcttccc
|
60781ctaagccaga ctccttagtg attcatgccc tgagctagac attggactag tgaggccctc
|
60841aggtgccctc caactctatg attctttggt cttactccac attgaagagg gctgatttag
|
60901agttggagga aagaaaaagc ctgcaggata gacgtatctt cagccttaga agaccaaggc
|
60961acagctctac atgtgtaacg acatgggcac cacagtgcag gcgtctggtt tcccaccaag
|
61021gaaaagcact gtctcattga ttttaccttc aacagcatct ggtattttat aagtctctgg
|
61081cttggtcctt tgagatactt aaaaagaggg agattgtgat ccagttggcg ctggcatacc
|
61141tttaaaagcc aaatagaaac aacataaagc aaaacaaaca acacacacag aataaaagtg
|
61201gcagcattta ggtacaaaac acaaaattgc ttttcctgga caacaggggc agctgtgtcg
|
61261agcagctcca taaggctgtg gggttgttct ttcccctagg aacagtgtgt gaaataagag
|
61321aaagaggaaa gaggacggct cggctaatat ttttacaggc atctagggaa gcagaaccat
|
61381ttatttcttt tagaaagcaa gttcactaga agacagtggg gcatttcaag tccttctgaa
|
61441aaagaggcca cctatcttca agttgggggc tgccagagtc tattcaggcc ttttggagcc
|
61501tgaaggatac agacggtttg tagacatcat tccagggagc ccaaagtgtg acatttttta
|
61561cttagtttca tttttaaaac ccatcttaga agaagacact ggttttctca ccagatatag
|
61621gtgctcctca caggcctatc ccattacaac ttttcatgtg taatttcaaa gtatgggaca
|
61681ctttaaataa acataaatcg caatgccaag ttcctctccc tagtcccact tttgatttct
|
61741ttaacaactt gatgcataga aacattttcc aggaagaagt ttgtcttctc aacattaccc
|
61801caaagtaggc gcagtcttga cactcttgcc agattgccct agctcggggc agattcttat
|
61861ggtatttaaa atatatctga agatcttctt tctaggtggg aaaaaattag aataaattaa
|
61921tcaggcagca tttttcagta agtggacagg atgatacagt ttattcattc attcaacaag
|
61981ccagagtatt ctaatgtgta aggaattggg ggtgtacagt aagtaatctt atgttgggat
|
62041gtgtgtgtga tggagagata aacagaaggc tttaaacaac cataactacc agacatagat
|
62101aggcacagag tgctctggga gcatctacaa gggctattgg taaatacata agtagactca
|
62161caaacaggaa ttggttttta tctttatcat tcttttcctg ccctttgtcc aggacatcga
|
62221catctcccca caacaggtct gcaatgagta gtaaaactga cagaaaagag gctggtgttt
|
62281gatggtcccc ctctcttctc tctccaccct ctccttgtgg tcatcgtgac accaaccctg
|
62341caaagaagcc caagaaacaa ccaaaagatg gaaacatgcc agaggggaga tgtggtagat
|
62401cgggcaacca atacggagct cagtcatttg ggcaaccctc aaagtgacag gctccgcctc
|
62461aaacatcact ttcaacctgc agcacaagac tctgagacag gaaatgttat gtgactgttt
|
62521cggagctaga gagcaaggag gactcaacgt gctgttcaac ctgtattctc atggtatcaa
|
62581agacgctgag aggtgggcac atatctgcca atctcccgga gagaaagcac actccaagcc
|
62641tctggcgtca gcttgccagc ttcactcgct ctatcaggga gcctggccca cagcggctgt
|
62701gctggccaca gatcccatgc cattctggtg gagaagccca tgtagccacc tccttgcaga
|
62761agtctgtgtc cctgtcctcc tgctcagccc aactctggat ttccttcatg tcaacacaga
|
62821tgattccttc cctctcagct tcaatgatgc ctgttctact cccaaataca ttgctatagt
|
62881ggatgacttc catttctgta gctctttctt tctcccaata ggttgtaagt ggtcatttca
|
62941gcataggaac tacagcaacc gtcctttgct attccctcca ggaaaaaaat ggcacacaca
|
63001tttaagacag atggcccttg aaaaatgttc agactggtta aggagctaga ataataactc
|
63061agagcttaac aatatagtat tgacctaaat tgctcttcta aaggctaaca gtccaaaatt
|
63121cctcagagaa aggatgtcca ctaaccagca acatacaaaa gtgcccaatt ctcctaatct
|
63181ccttatagaa tgaatcagga ggctataaaa ttgctaccag aaactcatat tcacacaaga
|
63241atacatactt gcttacggat taagactgcg gggctctggt ggcggatggt ccaggttcag
|
63301ttcttggctt tgccaaatac aaatcatatg gcctaaagta agttacctaa ccttcctaga
|
63361cttcagtttc ctcatctgtt aagtgggccc ataacagtag tcaactcctg tgactgttgt
|
63421gagattaaat gagatgatgt atagaaacct ctccacaaat gcccaatgga tagagtactc
|
63481aaaaaatggt ggctattgtc aaagcacttt ttactttatg gaatcctctg catacattat
|
63541tttgtttccc acaacaactg tacatattgg tactattagc ctgttgtgtg gaggaggaaa
|
63601gtgagattcc aaagtttaag ttatttactg gaggtcatgc agatagcaag tggcttgacc
|
63661aacatgataa atcgggtttc ctgacttacc agttactccc acatatcagt gtgagcaccc
|
63721attccagtgc tctttccatt ttaccatgtg agatctcaga gtacttggaa cccacagtac
|
63781actatggaca aatattattc tatatagaac atggtctctg gaggagaatt gtttcagaag
|
63841atacaggcta aagaggctga ttaaaacact tggtcagaaa actatttcaa aattcattat
|
63901cttggaaggc cgaggtgggc ggatcacgag gtcaggagat ggagaccatc ctggccaaca
|
63961tgatgaaacc tcgtctctac taaaaataca aaaattagcc gggcgtggtg gcacatgcct
|
64021gtaatcccag ctacgaggga gggtgaggca ggagaatcgc ttgaatcagg gagtcagagg
|
64081ttgcagtgag ccgagatcac gccacagcac tccagcctgg tgacagagcg agactccgtc
|
64141tcaagaaaaa aaaaaaaagt actacttgta ttttgtctct aacatcataa atcacatagg
|
64201gctaagtcag tgttttctgg ctgggttaat gatttacaat gttcctccca acatggcggg
|
64261gcgctatcaa aaaactttgt aaaactttac aatttaggag aggaattcag aaaaggtatt
|
64321tagttaataa ttctctgaca atttcctcat atttgaacaa tttgataata tccactttcc
|
64381cacaggaact ttgcccattt ctcattgagc aatttaaata atctttgcag taatgacata
|
64441cataaccata aaatacttct aatctctgaa actagatttc acattagtcg tttgttaagt
|
64501gcaaaaattc aaaatagtat ataaagcact aataatgtaa tagttcaaaa aaattaatga
|
64561atcagaatga gtataaaata gttttcagtg tacattgaat tctggtgctt tgacacaaag
|
64621cctatgatga gttgacatgg aaagccatat ggggccacca aaaggctctg agcatggaag
|
64681attccttctc tccattaatg tcaaatatct tgaaacctgg aggctttgtt tgcttccagt
|
64741tatcataagt attgctctca gcctcagtca taatatgagt tgcttacaac tttaagttgt
|
64801ttgatctgtt gccttgggtt cacaaaaata aaaataagaa agagaatgag aaggactagt
|
64861tgagaaagag aggagaaatg agaactattt agaaggcaca gggggtcagg atcatctcca
|
64921tggtcgtgtc ctagaaagta cctggtgggg attgatgttg ggtggaacat ttctctgtgg
|
64981cagctcccac tggcccatat agcctatttg ttgcctaaaa cagggtggag aaacagggaa
|
65041agagggaaga agtctgggag gtgggaagaa ggggtagttg gaggtataat gttgtaggcc
|
65101aagatgttca taaattgagt actaagccta aaggaggctg tagatttaga attttcgaat
|
65161catcctctat gttgtaaaaa atagaatgga aagaaaatgt atttcctgag gtttttagtt
|
65221taacaccagt gcttctcctc ttgagagcat tagtacagct ttattgtggg actctaacct
|
65281cgctgtatga ttcttgtttt aaaacgtagt tgagtcattc agaagaggat cctctgcttt
|
65341ggggaccatg gatggccagc cttccatttc atggggcttt gcaggaagcc aggcttgcgg
|
65401ttactcccac atatcagtgt gagctcagtc aaattggact cattctcacc ttggataaag
|
65461tcagataaag ttgggaggcc aactcatgtt ttccattcaa agggcagata caagatatac
|
65521tgtcttgaca aattgcaagt gtacagtaca gtattattcc atgatagtcg ccatgctgtg
|
65581cgttacatct ccaggactta ctcatctcat aactgcaagt ttgtaccctg tgaccaacat
|
65641ctccctactt cctctagact ccagcccctg gcaaccaccc ttctacttca atgagctcaa
|
65701ctgtttttgg attatatata tatacatata cacacacaca cacacacaat ggtaatgaat
|
65761gtattcatta acttgattgc agtaatcatt tcacagggtg taagtatatc aaaccatcat
|
65821gttgtatagt ttgaatatat gcaattttta tttaccaatt atacttcagt aaagcttgga
|
65881gtcggaggga agcagatatg tttttagacc attgatgttt ccatttgtcc ttgccactta
|
65941acgcagaaat gtaagggctg actttaacat gattatttac tgggagtaca gacttactct
|
66001cttgagaaag caatgtgcca gaagttcagg gttctcagca cacttttcca actcttttag
|
66061aaaagtccta gaaaaataaa agtatacaag taataatgtt ttgattttga catgtaggta
|
66121attaattttt taagtacaat cacataaggt ttcaagaggt gcctagaaaa atgttctcca
|
66181ggccttcttg ctcttatctt ctacacattg attcagRaaa aaaagctgta ttctgaggta
|
66241ttactacaat taccctgaaa tcactcacaa ctttaagttg ttcgatctgt tgccttaggt
|
66301tcacaaaaag aaaaataaga aagagaatga gaagaactag ttgRgaaaga gaggagaaat
|
66361gagaactact cagaaggcac agggggtcag gatcatctcc aattatcaga acacagctgt
|
66421tcgggtaatt ctaagcacta gtcatagata gactggatac attcactgat gctctctctt
|
66481acatgaaagt aacgttcata agaactgctg ctgctgctgt tgctattact aatatcattg
|
66541acagcttact ataagccagg cataagctaa gtgctccgca aatagtatct catttaatcc
|
66601tcaaccaaag atagggtttt ataaatataa aacctggggc tcaaagaggc tacataactt
|
66661ctctggggaa atcaacagaa atgggtttcc atttcagttt tgcgtctgac caacggacga
|
66721ggaatggggt taggaagcaa ctgtggttca attcaccaag cagcttttct ccctctgtga
|
66781attaggtgtg caatcttggg gtcatcatag cgaataaaga gagttaacaa gttaccattc
|
66841ccatatgtgt aacatgaaag ggtttgaaga tgatttccaa agtcccttat tcctgcaatt
|
66901ctctagaact caatatccaa gcagccccga gttaaaagta caacttgttt gagcagtcag
|
66961cattttctaa caccctagtt cccagcatcc ccttatgata gtagtatgga gatgtgtatc
|
67021ttggtcatct ttgtattccc aatgctgagc acagtgcctg gcacagaaca ggtgctcaaa
|
67081aaatgctgat gcatgaataa ataaacaaag gaacactcaa ctgcatacaa catggatgtc
|
67141tgacactggg tccctgttcc tttgatgtct cttccctttc tctccaggga tcctgtgggg
|
67201cttctcccct cctttcactc caacccaccc caatccaatc cactgactcc aaaccacttg
|
67261cttaaacctg aaaacatcta agtgttttca tctctcaatt ccatcagtct catttccacc
|
67321cttctSttac tctccattct ttctgataac atgaattatt atatacctgt tgtgaaattc
|
67381gtaaagttct ctaatattcc caaagagaaa gtccttgtta ttctgaagaa catctggaat
|
67441tagatgcttt agccaaataa aatccattgg agtgatatat ccctgcagag gtgcaaacaa
|
67501ggtaggtgtt acaaacagga acataccaga gatcatctga attagctact gcaaaaccca
|
67561aaactttagt gaaatgattg aagaatatag cacacttgtt tcttgaaagc tatcgtattg
|
67621agtactttct tttgatatca ttttcctcat gtgcccactt tcagaaggag atggcttaat
|
67681ggcaatgatc ataaaatggc atttttgtgg gaagaacaaa tatatttaaa aatgtttatg
|
67741ttacacaggt ttaatctaaa agaagggaaa atgtacccac tgttttatga actaatacaa
|
67801ttactattat tattatgatt attattaata ttgagacgaa gttttgctct tcttcccagg
|
67861ctggagtgca atggcgtgat ctcggctcac tgcaacctcc gcctcctggg ttcaagtgat
|
67921tcttccgttt cagactccca agtagctgga attacaggca cacaccacca cacctggcta
|
67981attttcgtat ttttagtaga gacagggttt caccatgttg gccaggctgg tctcaaactt
|
68041ctgacctcag gcgatccacc cgcctcggcc tcccaaaatg ctgggattac aggcgtgagc
|
68101cactgcatcc ggcccaataa ttatttttta atatctgaat aatgtttact cagcatatat
|
68161atcatagttt actaaacatt ccctttttat ggacatttgg gttgcttcta atattttatg
|
68221gtaaaaatgt gattataaat aatcgcgtac atataatttt ttccttaaga ttattccctt
|
68281aggaaaatag ggaaaacatg catttttact cttaagaaaa agactacttt aaaaaaacaa
|
68341gaaataatct tcccttatta aagtatcagg aacacttata atatcctttg ttggcaagaa
|
68401gatggtaaac ctatttgggc tttgctggaa tcagtgtgaa ctggcttaat tctttggaaa
|
68461ctatttggct acatggatca agaaaccaca gggatgttct tattcctact ggagacactt
|
68521gtaatattct aagacctgaa accttggtgg gaattctgga gacttctggc aactattttg
|
68581agtctctttg tacaacaaaa catctgcagt ttgaatatat gcttgatacc ccactcccca
|
68641aatctactta catcaattat gcttttaatc tcttttatgt aaatctcttc agtctcaagc
|
68701aagtcacgta taatgcgcct gaatcacagc agcaggtggg agggtgaaag agagagagac
|
68761agggagagga gaatgttctt ttagaattct gttagaataa tgctcatcaa tacagttccc
|
68821ttttagtggc tcacctactt agtttctggt cagttcattc tgttctattg aacacccaag
|
68881gtcagcatct cacaaacgca cactgtgatc acactggtat caagaagaaa cagcaaggtt
|
68941agagaactca aaatccttta ggcagccagt gaatgacctg tcctctgggt gggccatata
|
69001gtgtgggggt caagaaggga gatgttggag tcagaaatac caggtctgga tccttagtca
|
69061aggaaggtct gcctgacccc acccccaccc cctatattgt atacattgta taagtggttt
|
69121cctagatttt ctctccagct ttctgctcac atcaagcttt cttttccttt taagagaaag
|
69181ggtcttgccc tgttgcccag gaatgagtgc agtggcatga tcatggctca ctgtagcctt
|
69241gaactcccgg gctccagcaa ccctcctgcc tcagcctccc aagtagctag ggctacagat
|
69301atgcaccatc acacccagct aacgcctttt tttttttttg gtagagatga ggtcttgcta
|
69361tgttacccag gctggtctca aactgctact ttcaagcaat cctcctgcct ttgcctccca
|
69421aactgctggg attataggtg tgagacactg tgccaggcca gatccagatc tttgacccat
|
69481atggatgtat tttgttgtac atggggttag atgtatgcta gctccttcct ctggcattgg
|
69541atgtttcact gtgatttcct aaggcaaaag atatgacttc tgtctgcttc tgtcaaggaa
|
69601tgcaggtgga agatgtggtg gacagaattt aagacggtcc ccaagacttc tggccccact
|
69661gcacatacgc ctcttccaat caaacactaa tttaggggat gctgtggaag gattttgctg
|
69721ttcatttgat aggtaatcca gttgggcctg tcctaatcat atgaactcag atctatMtgg
|
69781gtcaagtggt cagagactgg aagcataaaa aagattcaac acaaaggaga ttcccctttg
|
69841ctgacttttg agatggaggg ggccagatgg aatggaatgt gggcagccgt aggaactgag
|
69901agtggctccc agctgacagg cagcaaggaa gggaaatcag tcctatagtt gcaaggaacc
|
69961gagtcctgcc acaaccacgc gaacttagaa gaggatccag agctccacat gaaaacacag
|
70021ccagccaaca ccttgacttt agccttgtgg gactcctgtc ccagggaaac tgtaggtctc
|
70081ctaagtttgt ggtcagtttt tatatagcaa tagaaaacca gtagaaagag taaggccagt
|
70141ccccacatct atcccagaca gactttcttt ctctcctcag gctacgtggc catatttatt
|
70201atttctttta ggagtccaag tagatgagtg tttatacatg tgtccttgtg tagaatatat
|
70261atatttattc ttgttaacta ttgatggatt atctattaaa tggcagcctc tcctagaaaa
|
70321tgatttgttt ttctctcata aaaatggatg tgacaaatga tccaatagaa aaaaatggga
|
70381aaggacacaa aataggagat tcacacaaat attcaaatgg atatgagact cgtggaaaaa
|
70441atactcagta catacattca acgaaggcat attttaaaag agcaacaatt ttcatctatt
|
70501agaatattaa acatttcaaa cctcatagaa agactggtaa atgagggtgt ggaaaaaccc
|
70561tcacacaata ttggtaaaat gtgtaaattt gtgcaagctc tttggaaggt aatttagaaa
|
70621catctcaccc aaatgtaaaa cacgtgctcc ttggttcagt aatttcactt ctaggaatgt
|
70681tcattgttta taattaggac aatataactt caacaacaac cagatataaa ctggttactt
|
70741aaatgctcat caaaaaatta tggtacatgg gccgggcatg gtggttcacc cctgtaatcc
|
70801cagcactctg ggaggctgag gcaggtggat cacttgaggc caggaaatcg agacCagcct
|
70861ggccaacatg gtgaaaccct gtgtctacta aaaatacaaa aaattagatg ggtgtggtag
|
70921cgcatgcttg taatcccagc tacttgggag ggtgacgcag gataattact cgaacccagg
|
70981aggtggagat tgcagtgagc cgagatcaca ccattgcact ccagcctggg caacaagagt
|
71041gaaactccat ctcaaaaaaa aaatatatat atacatacat atagatatag atagatatat
|
71101gtgtgtgtgt gtgtatatat atatacatat atatggtaca tacatataat gatgaaatac
|
71161catgcaattg ttaaaaagaa tgaggctgac taaaacactg atatgacaga ggccaggtat
|
71221ttttagtgaa aaaacaaaac aagacgtaga caagtaagca tagtatgact atttgtgtaa
|
71281aaaatgaatg tgtatgtaga aatatacgta aaactgtata tgctcagaaa atttatgcaa
|
71341agaaacttaa cacattgtta aaagtgattg cttttggaga gtggtactga aagctaaagt
|
71401atgggaaagg agaatttcta catcttactc tatacccttc tacaatcttt tttaaagtga
|
71461aacatttact gcttttataa tggaaaaata gggtttacat aatattttaa aatgaatgtt
|
71521actggaggta atgatatgta aaccctattt gatagatata aataaataat acaattcaca
|
71581tattttacag ctcattattc tttcttataa tcatttttgt gtctatttat aaatacttgt
|
71641ataagacaag actgataaac aagatgtacc acagaggatg taatttccgg aagtctaaaa
|
71701ctcccaaaaa gttacttaaa catcatactt tactaagtca ctgagaaaga ggttcctatg
|
71761ccttttataa atcacccgga aacaacaacg gtttctatgt cagaaggaag tacaggcctc
|
71821aataccaata tgtttctacg agccctggca tcaagtggga ccacagcaac agttaagcat
|
71881tcatggaaaa cctgagtaca atcagcctct tatgccttca tgaagcactg ggcttaagca
|
71941acttggcaag ctggcttcag gatgcattga caattaaagg aagtcagaag gcagaaataa
|
72001ccaggaggtg gacagaagtc aaggttatta tccaaaaatg atctatgaac ttaagagact
|
72061cttaggagct tttaggactc taatacagga aaatattcac atctctgaag gaaaagaaat
|
72121cccttggtca tattctggat tacagtttgg aaaaaaagtc tagaaatctc atccaactgc
|
72181ttcattttac ctgttggagt gcaagagata aaatgccaag gataggaact ccactgaaga
|
72241atgtaggcaa atcaatattc attaaataca ttcaaattaa tatatgactt aaaaagagcc
|
72301ctcacatcag tgttaggcca ttgcttttcc ttgcttctct tgttttcctt tcaaatacct
|
72361ttataaaata ggagaaaatg tatgactctt tttttttttt tttttttttt attatactct
|
72421aagttttagg gtacatgtgc acattgtgca ggttagttac atatgtatac atgtgccatg
|
72481ctggtgcgct gcacccacta atgtgtcatc tagcattagg tatatctccc aatgctatcc
|
72541ctcccctctc ccccgacccc accacagtcc ccagagtgtg atattcccct tcctgtgtcc
|
72601atgtgatctc attgttcaat tcccacctat gagtgagaat atgcggtgtt tggttttttg
|
72661ttcttgcgat agtttactga gaatgatggt ttccaatttc atccatgtcc ctacaaagga
|
72721tatgaactca tcatttttta tggctgcata gtattccatg gtgtatatgt gccacatttt
|
72781cttaatccag tctatcattg ttggacattt gggttggttc caagtctttg ctattgtgaa
|
72841tagtgccaca ataaacatac gtgtgcatgt gtctttatag cagcatgatt tataatcctt
|
72901tgggtatata cccagtaatg ggatggctgg gtcaaatggt atttctagtt ctagatccct
|
72961gaggaatcgc cacactgact tccacaatgg ttgaactagt ttacagtccc accaacagtg
|
73021taaaagtgtt cctatttctc cgcatcctct ccagcacctg ttgtttcctg actttttaat
|
73081gattgccatt ctaactggtg tgagatgata tctcataatg gttttgattt gcatttctct
|
73141gatggccagt gatgatgagc atttcttcat gtgttttttg gctgcataaa tgtcttcttt
|
73201tgagaagtgt ctgttcatgt ccttcgccca ctttttgatg gggttgtttg tttttttctt
|
73261gtaaatttgt ttgagttcat tgtagattct ggatattagc cctttgtcag atgagtaggt
|
73321tgcgaaaatt ttctcccatg ttgtaagttg cctgttcact ctgatggtag tttcttctgc
|
73381tgtgcagaag ctctttagtt taattagatc ccatttgtca attttgtctt ttgttgccat
|
73441tgcttttggt gttttggaca tgaagtcctt gcccacgcct atgtcctgaa tggtaatgcc
|
73501taggttttct tctagggttt ttatggtttt aggtttaacg tttaaatctt taatccatct
|
73561tgaattgatt tttgtataag gtgtaaggaa gggatccagt ttcagctttc tacatatggc
|
73621tagccagttt tcccagcacc atttattaaa tagggaatcc tttccccatt gcttgttttt
|
73681ctcaggtttg tcaaagatca gatagttgta gatatgcggc attatttctg agggctctgt
|
73741tctgttccat tgatctatat ctctgttttg gtaccagtac catgctgttt tggttactgt
|
73801agccttgtag tatagtttga agtcaggtag tgtgatgcct ccagctttgt tcttttggct
|
73861taggattgac ttggcgatgc gggctctttt ttggttccat atgaacttta aagtagtttt
|
73921ttccaattct gtgaagaaag tcattggtag cttgatgggg atggcattga atctgtaaat
|
73981taccttgggc agtatggcca ttttcacgat attgattctt cctacccatg agcatggaat
|
74041gttcttccat ttgtttgtgt cctcttttat ttccttgagc agtggtttgt agttctcctt
|
74101gaagaggtcc ttcacatccc ttgtaagttg gattcctagg tattttattc tctttgaagc
|
74161aattgtgaat gggagttcac ccatgatttg gctctctgtt tgtctgttgt tggtgtataa
|
74221gaatgcttgt gatttttgta cattgatttt gtatcctgag actttgctga agttgcttat
|
74281cagcttaagg agattttggg ctgagacgat ggggttttct agataaacaa tcatgtcgtc
|
74341tgcaaacagg gacaatttga cttcctcttt tcctaattga atacctttta tttccttctc
|
74401ctgcctgatt gccctggcca gaacttccaa cactatgttg aataggagcg gtgagagagg
|
74461gcatccctgt cttgtgccag ttttcaaagg gaatgcttcc agtttttgcc cattcagtat
|
74521gatattggct gtgggtttgt catagatagc tcttattatt ttgaaatacg tcccatcaat
|
74581acctaattta ttgagagttt ttagcatgaa gggttgttga attttgtcaa aggctttttc
|
74641tgcatctatt gagataatca tgtggttttt gtctttggct ctgtttatat gctggattac
|
74701atttattgat ttgcgtatat tgaaccagcc ttgcatccca gggatgaagc ccacttgatc
|
74761atggtggata agctttttga tgtgctgctg gattcggttt gccagtattt tattgaggat
|
74821ttttgcatca atgttcatca aggatattgg tctaaaattc tcttttttgg ttgtgtctct
|
74881gcccggcttt ggtatcagaa tgatgctggc ctcataaaat gagttaggga ggattccctc
|
74941tttttctatt gattggaata gtttcagaag gaatggtacc agttcctcct tgtacctctg
|
75001gtagaattcg gctgtgaatc catctggtcc tggactcttt ttggttggta aactattgat
|
75061tattgccaca atttcagagc ctgttattgg tctattcaga gattcaactt cttcctggtt
|
75121tagtcttggg agagtgtatg tgtcgaggaa tgtatccatt tcttctagat tttctagttt
|
75181atttgcgtag aggtgtttgt agtattctct gatggtagtt tgtatttctg tgggatcggt
|
75241ggtgatatcc cctttatcat tttttattgt gtctatttga ttcttctctc tttttttctt
|
75301tattagtctt gctagcggtc tatcaatttt gttgatcctt tcgaaaaacc agctcctgga
|
75361ttcattgatt ttttgaaggg ttttttgtgt ctctatttcc ttcagttctg ctctgatttt
|
75421agttatttct tgccttctgc tagcttttga atgtgtttgc tcttgctttt ctagttcttt
|
75481taattgtgat gttagggtgt caattttgga tctttcctgc tttctcttgt aggcatttag
|
75541tgctataaat ttccctctac acactgcttt gaatgcgtcc cagagattct ggtatgtggt
|
75601gtctttgttc tcgttggttt caaagaacat ctttatttct gccttcattt cgttatgtac
|
75661ccagtagtca ttcaggagca ggttgttcag tttccatgta gttgagcggc tttgagtgag
|
75721attcttaatc ctgagttcta gtttgattgc actgtggtct gagagatagt ttgttataat
|
75781ttctgttctt ttacatttgc tgaggagagc tttacttcca actatgtggt caattttgga
|
75841attccctgct ttattattct aaagcaagct tgtccaacct gcggcctgtg gcccaacaca
|
75901aatttgtaaa ctttcttaaa acgttatgag attttttttg cgattttttt tttttttttt
|
75961tttagctcac cagctatcgt tagtgttaat gtattttttg ttttgttttg ttttgagacg
|
76021gagtcttgct ttgttgccag gctggaatgc agtggtgcag tctcggctca ctgccacctc
|
76081tgcctcccag gttcaagcaa ttcccctgcc tcagactccc gagtagctgg gactgcaggc
|
76141gtgcgccacc atgcccagct aactttttgt atttttgtag agatggggtt ttaccatgtt
|
76201ggccaggatg gtcttgatct cctgacctcg tgatccaccc tccttggtct cccaaagtgc
|
76261tgggattaca ggcgtgagcc acctcgcctg gccagtgtta atgtatttta tgtgtggccc
|
76321aagacaattc ttcttcttcc agcgtggccc aggaaagcca aaagattgga cacccctgtt
|
76381ccaaagcatg taattttatt cacagaaaag actctcggcc gggcgcggtg gctcacgcct
|
76441gtaatcccag cactttggga ggccgaggca ggcggatcac gaggtcagga gatgtagacc
|
76501atcctggcta acacggtgaa accccgtctc tactaaaaat acaaaaaatt agccaggcgt
|
76561ggtggtgggt gcctgtagtc ccagctactc gggaggctga gacaggagaa tggcgtggac
|
76621cccggaggtg gagcttgcag cgagccgaga tcacaccact gcactccagt ctgggcaaca
|
76681gagcgatatc cgtctcaaaa aaaaaaaaaa aaaaaaaaag actctcaagg atttaccatc
|
76741taaaatcatc aagtgtatat catgcagatg aacaacagaa aacactggga gtattcaagt
|
76801aattaaaaat aacctttcag caccaacagc aatttctgtc ctgatggcaa tctactcaga
|
76861gctagaggac tgcacttagg ataccaaagg gagcttagga tgcaagagca gcctgcacta
|
76921atgtactctg cgttagttta catccgggca ctttgcttta cgtttcaaaa cagacgccgc
|
76981ccttagctca ttaaagggga aatggaggta taatgtgttt taaagggatg tttcttctct
|
77041gaagccatat ttcagggtag catgaaaaca gagctttgga tatctggttc cattctacat
|
77101gacacctcat gcttgtttca aatgacacca caaccaaggg gcaggaatga aaggaatatg
|
77161ctaaaaaaaa aaaatgcaat cctttttagc aagaaagatc attaaggatt tcctgataag
|
77221tttcttcttt gttcatgtgc cctcctctgc tccccctttg aactactgcc cctgtcaccc
|
77281ccccttcccc gcctccccgc cgtttctcag ttctccaata gggatccagt ctgccagagg
|
77341tctatttttg ctcattattg tcaacacaat ttgccatcaa gagttttcac ttactcctgc
|
77401tatcctatca tcacattatg catgtcagaa agcattacag atttttactt ttcaagaacc
|
77461cgaactcaga tttccaggct tctgtccttc ctgtttcatg ctgttgactc tcccacatct
|
77521ttgtcttcct cctagacctt tggtcactct tgagcccaca ttgccaatgg tctatatcat
|
77581tttcacctgg atgcctccca gacacctcag tcacatcaag ttgaaataga actaattaga
|
77641cagaagtagc atgtgtttca gtggaactga catttttcta gggtccctaa aacacaggtg
|
77701ttgtttcaaa ctcccccctc caacatccct tatattctct ctgtcaccca ggctccttat
|
77761atcatctctc aacatgcttc ctgggtgact actgactctc cacttctggt gacaccccac
|
77821agagcaagct ttcaattcct gtcatttaaa cactttagtg cactcataga atctcatcct
|
77881tctgagattt ctcttccacc agtctatttt gcagaccacc aggctacgcc cttccaaaag
|
77941ctcctttgag atggagtttc actcttgttg cccaggctgg agtgcaatgg catgatctcg
|
78001gctcattgca actgccacct ctcaggttca aatggttctc gtgcctcagc ctccccagta
|
78061gctggggtta aagttgcctg ccaccatacc cagctaaatt ttgtattagg ggttttacca
|
78121tgttggccag gctggtctcg aactcctgac ctcaggtgat ctgccaccta ggcctcccaa
|
78181agtgctggga ttacaggtgt gagaaaccac gcctagtccc ccaaagctcc atttttatcc
|
78241tgtcttcatt ctctcttcaa gaacttgcdc acagctgcca gagttccttc taagagttta
|
78301agactctctg ttcatgtggt aagaatcttc ttaaggagct tgctttaaag gtaaaaccag
|
78361atttacacat cagaatgggg agaggtgggt gggagctaag atggaatctg taattttcac
|
78421aagtgccctg gatgattcta ctgcagatgg tctcctattc aactaaatag cactcatctg
|
78481acccactcct tttagacccc acttctgtta agccagtgtt atcgctattt tccactttct
|
78541ttcaagttct aatcatcctt aaaactccaa cagcttcagc tgaaatcagt accacactct
|
78601catccttgtt tcccacccaa aaactattgt actaattgac cagacatgta ttgatgccct
|
78661actatgagcc tggctccatg ataggcactt gggatagaga aatgtaccat aatcctgacc
|
78721ttaataaatt tagagtctaa tggaagagat aaaaaaaatc aatgattcca atgagtgtga
|
78781taaggtaagg ctagtcagaa aagtcaggtg cagaggaggg gcaactaatt aaaccagggg
|
78841ttgggggaga cactgccaac tctgtgttga gtgaagttta agcagaggtt tttctttaag
|
78901taaaaaatca gtttttttaa ataaaaagtt ttttaaaaag taagggggaa tagaagaagg
|
78961aggtttgtcc ctaaggggaa cagtgtggag gaggaaagga ggtgaaagtg tatgctattc
|
79021tgtgtactgg caaattcttt ggtgggtgat atggtttggc tctgtgtccc cacccaaatc
|
79081tcaccttgaa ttgtaataat ccccacatgt catgggaggg acccagtgga aagtaattga
|
79141atcatgaggg caggtttttc ctgtgctgtt ctcatgatag tgaataagtc tcaggagatc
|
79201tgatgatttt ataaagggcg gttcccttgc acatgctctc ttgcctgcca ccatgtaaga
|
79261catgcttttg ctcctccttt gccttccacc atgattttga ggcctcccca gctatgtgga
|
79321actgtgagtc cattaaacct ctttccttta taaattaccc agtctcagct atgtctttat
|
79381taggagcatg agaatagact aatacagtaa attggtactg gtagagtggg gtgctgcagt
|
79441atctgaaaat gtggaagcaa ctttggaact gggtaacagg cagaggttga aacagtttgg
|
79501agggctcaga agacaggaag atgtggtaaa gtttggaact tcctagagac ttgttgaatg
|
79561gctttgacca aaatgctgat agtgatatgg gcaataaagt ccaggctgag gtggtctcag
|
79621atagagatga ggaacttgtt gggaattgga gcaaaggaga ctcttgctat gttttagcaa
|
79681agagcctggc agcattttgc ccctgcccta gagatctgtg gaaatttgaa cttgagagag
|
79741atgattcagg gcacctggca gaagacactt ctaagcagca aagcattcaa gatgtcactt
|
79801gagtgctgtt aaaagcattc agttttatgt attcacaaag atatggttcg gaattggaac
|
79861ttatgctcaa aagggaagaa gagcataaaa gttcagaaaa ttggcagcct gatgatgtga
|
79921tagaaaagaa aaacccattt tctgaggaga aattcaagcc tgctgcagac atttgcataa
|
79981gtaagatgga gccaaatgtt aatcaccaag acaaagggga aaatgtctgc agggcatgtc
|
80041aaggaccttt gtggcaaccc ctcccatcac aggctcaggc ctaggaggaa aaagtggttt
|
80101tgtgggccca gcccggggac ccctgctcta tgcagtctag ggacttgttg ccctgcatgc
|
80161cagttgctcc agccatggct gaaaggggcc aaggtacagc tcaggccatt ggttcagaga
|
80221tgcaagcctc aagccttggt ggcttacacg tagtgttggg cctgtgggtt cacagaagtc
|
80281aagaattgag gtggatgtac agaaatgcct ggatgtccag gcagaagttt gctgcagggg
|
80341tggggccctc atggagaatc tctgctaggg gagtatggaa gggaaatgtg gggctggagt
|
80401ccccacacag agtgcccact gggacactgc ttggtggagc tgtgagaaga gggacaccat
|
80461cctccagact ccagaatggt ggatccacca acagtttgca ccatgtgctt ggaaaagctg
|
80521cagataccca acaccagccc atcaaagcaa ccacaagggg ggctgtaccc tgcaaagcca
|
80581caggggcaga gttgcccaag gctgtggtgg gaacccacct cttgaatctc tatgagacat
|
80641ggagtcaaag gagattatit tggaacttta aggtttgact gctttattgg atttcagact
|
80701cgcataaggc tgatagcccc tttgttttgg acaatttctc ccattttgaa caggtatttt
|
80761tacccaatgt ctacacccac attttatctg ggaaatagct aacttgcttt tgattttaca
|
80821ggcacatagg tggaagggac ttgccttgtt tcagatgaga ctttgaactg tggacttttg
|
80881agttaatgct gaaataagtc tttgggggac tgttgggaag gcatgatttg tcttgaaatg
|
80941tgaggacatg agatttggga ggggccgggg tgaaatgata tggtttgtct ctgtgtcccc
|
81001agcttcatca ggatcctccc acacatcccc attctaagtt gcagggtccc attcttttcc
|
81061aatcaatgcc ctcattttaa cagtagacac ctggtgaggc tgtgcatgca cctttcattg
|
81121caggtcagcc gctcccatga taagagcttg tatctgattt tccacaattt cagctctttc
|
81181tctacaagag ataagactct cactctggac aatcttagaa gatttgaggc tcagtgtatg
|
81241cttctggagc tgggagttag aatccctaag ttcatggttt tcttctatca gtttgtccag
|
81301tgaacttagg agcaaccaac caacttcgtt atattccttg gtcctctata tatggtcaaa
|
81361ggtattatgt atagagtcat taaactcctt gcctctcatg agtggtgaat caggagtact
|
81421gaatgcattt cttttgcata agtgtttgaa cagttcgtgc caaggactat cagtgttctc
|
81481cacacaatta gaagtagagt ccttagcatt ttggggtcta atcatattaa gcaaccaact
|
81541ccagaaaccc aaaaaccaac taaagaaatc tatccttctg taatcccagc actttgggag
|
81601gccaaggcag gcggatcacg aggtcaggag actgagacca cagtgaaacc ccatctctgc
|
81661taaaaataca aaaaattagc caggcatggt ggcgggcacc tgtagtccca gctactcggg
|
81721aggctgaggc aggagaatgg catgaatcca ggaggcggag cttgcagtga gctgagattg
|
81781cgccactgca ctccagcccg ggtgacagag tgagactcca gctcaaaaac aaaaaaaaag
|
81841aaaaaaaaga aatccatcct taaaattctg ttcctctaga accattccca gtaccaaaat
|
81901ctgattaaaa aaaaaaaaca ggcagaggaa ggtggaagga ctagatcttt ctccagtgct
|
81961ggatgcttcc tgccctggaa catcagactc caagttcttc agcttttgga ctcttggact
|
82021tacaacagta atttgccagg ggctctttgg cacttggcca cagactgcag gctgcactat
|
82081cagcttccct atttttgagg ttttgggact cagactggct tcctgactcc tcagcttgca
|
82141gatgcctatt gtgggacttg gtatcttgtg attgtgtgag tcaactctcc taataaactc
|
82201cccttcatat attcatctat cctattagtt ctgtaccttt agagaacact gactaatgcc
|
82261gtggggttaa gccaatcgtc tagtaggttc ataaaatgct aaaagcagat ataaacttaa
|
82321agacgatcca gctcatctct tcattttaca gatgtaaaaa cagaagtaga aatagaattg
|
82381gaaccccagt ttcttgaaac ccagtgtttg cataatacca tgctaatttc attctaattt
|
82441gtgttttatt taataatcag gaaacagttc aaatagaggc ccagggctct gaaacattgc
|
82501ccaaggtcta tggcttttgc aaagcaagta ctgtttctgc tactttacct agttgctctt
|
82561ggcctatgtt tggggtgcat ctaaagaact gtttgctgat tattaaataa aacacaaatt
|
82621agaatgaaat tagcatggtg ttataaaaac acagggtttc aagaaactgg ggttccagtt
|
82681ctatttctac ctctaggata cagggtaagt cacttccttt ctcagattct gtttctttgt
|
82741atgtcaaagg gctggattag ataaacttga cttcccctct tggccctcat gtatcattct
|
82801ataaatatgt tatcatttct aatagactgt ttgatgtaat cttttgtcta atggcccctg
|
82861cttttcacaa taaatgaaac aaaggtcaca agacttttat tcatttgcaa ccctgattaa
|
82921ctaacagtta atgtgtaact ggagtgccac atagaaacag aaaggagaag gggaatggat
|
82981tgggttggag aaggtgaagt ctgacctatc ctctacaaga ggtacagggt ttatccagga
|
83041agacaggagt gccatgagga gtaaactcca gcaggggctg gagtcatggc cacacacagg
|
83101gccttacagg atccaggctg cccagagcag agtttggatg ggggctggga ggctggggga
|
83161gctagctgag gagatggttg tcatgccagg ccacgagtgt ggatgagtgc tggccagggg
|
83221aggtatagga gattgatggg gctgtggcaa gcagggcaga tacccttcca ggaacctgtt
|
83281tcattaaaca cagaatacag tcctgagggc tcggtctcaa tacagtcctg agggctcggt
|
83341ctcaggaaaa catgttctta agttttacat ccttcttctg ttttgattag gtgtttcctg
|
83401attataaaat aaattcctag aactgttaat ggtaacaaca caaagcacta tagacccata
|
83461cgaggatcat attgaaacca atgacattta agaataaaag atctgatgaa tatgaacact
|
83521tccctggttc ctaggaggat aacagttgag ttttgctcag gtaatctgcc ttctcttcct
|
83581tcttctctgc tttRtatctc agtttctata ttttgtctta cattaatagg atttgttctc
|
83641attaccctga tgattttatg gtaaactacc tcaaattctt tttggaagaa gatgggatat
|
83701aaattatttt taaagtttat ctgaatagat gttcttcaat atcacacaat aaataatgac
|
83761aatgtaactt tgtgcatata gcactttaag agattgatca taaacacaat cctattaatc
|
83821ttaattcaag ttaataatgc ttgcatttgt atggcatttt aggtattata aagttttttt
|
83881taattgtggt aagatatgca taaaatttac tatttaaacc tttttgaagt gtatagttca
|
83941gtagtgttaa gtacattcac aatgttgtgt aaccatcacc actagccatt tccagacttt
|
84001ttcatcatcc caaactgaat ctctgtacct attaaacatg acctcattct ccacctcccc
|
84061acagctcctg ggaacctcta ttctactttc tgtatgaatt ttcctattct aggtgtctca
|
84121tataagtgga atcatacaat attcatcctt tggtgtctgg cttatttcac gtagcgtaat
|
84181gctttcaagg ttcattcatg ttgtagcatt tatcagaatt tgattcattt ttaaggctga
|
84241atatcttcca ttttatgtgt ctaccacatt ttgcttatcc attcttctgt tgatgaacac
|
84301ctgggttgtt ttcacctttt ggctattgtg aataatgctg ctatgaacac tgatgtgcaa
|
84361gtacctgtct gagtctctgc tttcaatttt gggcatatac ctagaagtgg gattgctgga
|
84421tcataggatc attctatttt taactttttt gaggaattgc cataccaccc gctacagcag
|
84481ccgcatcttt tatattgcca acagtgcaca aaggctctga tttctccact ttctggtcaa
|
84541catttagatt atcattcttt ttttaaaaaa acgtaataSc taacccaatg ggcatgaagt
|
84601aaggttgttt ttgttttttg tttttaatgt gtgcgttatc ttacttgatc cattaaatcc
|
84661ctaacaagaa ctcctctagg gcagatgtcc tgtcttattc atccttggcc ccagtgtctt
|
84721gcaagcaagt gaattctcaa taagtgttaa ttgaatggat ggttgataga tttataggat
|
84781gcatgccaat tctgtggacg agagtaggta ctaattgtta ttttcatttc acagaagagc
|
84841aagtcagggc tccgagcact aagtgacttg gctgaggtca aactgcctgc aagttttatc
|
84901taatagtgac agaggaacca atgtgtcgag catgaatgtc agtccattga aacagtgccc
|
84961acttttctga ctctgctcct taagagacag ggcctgtaca gcaaggacac agagaagcag
|
85021gttacagaaa aagggctggc tcatccgtgt atgcctggca tttgaggaat gtggctgaaa
|
85081tctcaacact ctggttcaga agcacatctg caatcaaata taacaagaca tggtatgaga
|
85141gatgtctggc ataccaagga gattcctaga atacagcgga taggaaaacc tcattacttc
|
85201aattcccaag aaagagtact actggtagta atcccaacag gagtatccaa gtaactcggt
|
85261aatcttcagt aaagaaaaga aattgtgaaa caattatagt cagtcctcca tctctgtagg
|
85321ttccacatct gtggattcaa ctcacctcat attgaaaata ttaataaata aataaataat
|
85381aacaatataa caattaaaat aatgcaaatt ttaaaagcat aacaactatt tacatagtat
|
85441ttatattgta ttaggtatta taagtaatcc agagattatt taaaacatat gggagagtgt
|
85501gcataggtta tatgcaaata ctacaccatt ttacataaga gacttgggca tctgtggact
|
85561ttgttatctg caagggtcct ggaaccaatt ccccatggat actgagggtc aactgtacca
|
85621agYtgaaaac aaaacaaaag gaaatctatt gcaaaaagga aattcccaaa gataaaaagc
|
85681atgtctatga aatagtcaaa gagccgaaaa tgttgggaag acccacactg ctttccctgc
|
85741cctgtgcccc tttttgcaga tctatttgtg tctttatcta ccagcagata ttctattatt
|
85801ctaatagatt cctgtttttc ccaagagggt ttacttattt attaaatatg atgcaaacat
|
85861ctctctcaga gatgttgctc tctcttccta ggattcctta gccctaaatc tgcagagcca
|
85921attaggtatt aatattgggc tttacaactt tggaccatct gaccaccaag actgattcat
|
85981taaatgtata tggtttcaga tcacattaat ttatcataga ctttagaatt ggctttttag
|
86041aagtactgct ataaggaaaa tctcagcata gcaagtttta tctaatagtc tacttgtatt
|
86101aaagagtact caatgtaaac cctaggaaga cttttaactg ccttttggaa attggttgag
|
86161tgggatttga accgtgtact ctctgtaaag caggaaatta tcacttagta attactaagt
|
86221atttaaaaat gggaaataga aaattacatt tcagacctgg tgcagtggct catacctgta
|
86281atcctaacac tttggcaggt ggaggcaggt ggatcgcttg agcccaggag ttcaagacca
|
86341gcctgggcaa catagtgagc aactccattt ctactaaaaa taaaaaaaat tatttgggcg
|
86401tgatggggtg cacctgtagt ccccactact caggaggctg agacaggaag attgcttgag
|
86461cctagaaggt caagcctgag tgagcagtga ccggccattg tattccagcc tgagcaacac
|
86521agcgagaccc tgtctcaaaa aaaatgtata tttttaaaaa aagaaaatta cattttagtt
|
86581gttccataaa tatcagtaca accaaaccta agtgcaaaat tcccaacaca aatgatcgcc
|
86641tctgggccag ccatgtagcc cccatcttgc tgtcaataat catttccagg ggctgtaatt
|
86701gtcttccttc cccctgtacc accccatcac aggacacaaa ttgttttgct tagtttagat
|
86761agctgtgact aaactaagtg ccaattgtct tttaaaatat gtgttaatca gcactcaaga
|
86821ttgttcctac aaaaatgtca ctccctcact caatttgcat gtgccctcct gagtaggaga
|
86881gaaagagctg agttagaggc agccctctgg gacctgcaca gaaccctgta tgcttccggg
|
86941agtgtggagt gtgtgtctga tctgctgctg ggaaaaggag aagaaatgct gagacactca
|
87001ctgccagggg ctggtatcag gccattttca caggggctgt tggagggttg acagcacagc
|
87061tctactggac cagggagggt cccagccagc agggcctgcc cctccgaaac tgtccctgtc
|
87121cctgtccctg agaggcccca ctgagtgtca gatggcacat aagagatttc cttatgcgtt
|
87181ggtgtgaagg agatgatcag ttccaggagg cccctccccc atgcagaaga gaagaaaatg
|
87241gaagaaaccg ggttctcaga gtggcctgcg ggtgagtgcc gccttgtgct gtcagttccc
|
87301ttcaccttcc agttctgggt gtacctagtg tggtttcatc aaactgctga ggccctggaa
|
87361ttgagggagg atgctgaagg gtgccaggcc atagaagcag tagcaggagc tgcagcaaag
|
87421agctagtgtg tctccagcgt cagcttttgg gccttggtgg catcaaagga gacgtacaca
|
87481gggccactgt actacggatg ggattcttgg aacaaaagtt tgaataattg atgagtgtgg
|
87541aagtgctatg caaaaattca attcaacctg cagttaccag gcattcattc tgtgacaggc
|
87601attattgtga gggtggcaag gagacgggga gtctctgaga gactcagaga agagcagggc
|
87661atggtgtcca cccacaagag atctgaagac tttcaaagta gttgggaaaa cagacataca
|
87721acttttttcc cctccccaca gctagttgag gcaaaagaca tataacttat acagtgacaa
|
87781aatactactg actgttactg acacataaca gcctgggctg ggtcactggt gagaaaaagg
|
87841aggattcttg cttttggggc attcaagtcc tgtccattaa ccatttccca atcccatatt
|
87901tatacatccc attttagaca tattaagctg aagattgatg tgacataccc aaagacactt
|
87961aaggttgaag ctgagaatct gggctagaaa tataaatcag gatgggctgg gagcggtggt
|
88021tcacgcctgt agtcccagca ctttgggagg ccgaggcggg cggatcactt gaagtcagga
|
88081gttcaagacc tgcctggcca acatggtgaa accccatctc caccaaaaat ataaaaaatt
|
88141agccaggtgt ggtggtgcat gactgtaatc ccagctactc gggaggctga ggcaggagag
|
88201tcacttgaac ccgggaggca gaggttacag tgaaaggaga tcgtgccact gcactccagc
|
88261ctgggtgaca gagcgatact tcgtttcaaa aaaagaaaaa aaaaaaaaag aaagaaatgt
|
88321aagtcaagat taaagacaat gggtgagatc agcaaggagc atgtgtgcgg agaagagaac
|
88381accaaggaag gctgcgtgtg gtgggaggtg gccggggggc agagaaagag gcggcggagc
|
88441caaggagata gggcatcgtc tgaatggtga tgctgtatca acagatgtga aattcccaga
|
88501ggtgtgaaac acagcagatc ctttacagca cgatgacagg acacagcatg agcctacctc
|
88561tgccaggtga gaggagcttt ctgcaacctg tgatgggctc aaggatgctg accattcatc
|
88621cgcccattgg gatagcccag gctctgagct cagcactcca cccgtcactg cgattgcact
|
88681aatcctcacc cacccttgca ggcaggtatt actgtgggca cagagaagtt tgctaacttg
|
88741ccagagatcc tgtgtaggaa gccaggtcag gaaacaacca gagtctctct aacagcccag
|
88801gccttgaatg aacaccggcc tgcttcagaa tacatggccc gtgatgtgtt tgaattcaca
|
88861gattcactgg acaggttccc tatagggcct gtgaggaaat ctggtctaac agaatccaga
|
88921aagacaaatt tcgctaaaca ggtcaagcct gatactgctg ctacacttca gctgtgttaa
|
88981gccactcggt tatcagacct gcttctcctt tcatgatttt agtaacacag gcctcttcct
|
89041tgggcccctg ttgctcccac catctcccag gttctcttgt actcagggtt tagtctcccc
|
89101tccccactac taatgatgca tgtgccttac tctctgatca tctctcctaa atctgctact
|
89161cctctgctct ttctgtgcct tatctatccc tgccgagtct aacatgcaga ttttggtcat
|
89221tccaaagtca tgtatagatc taatcacagg gctctctgct taccagctgc tacttggata
|
89281aggaaagcat gccaacacgg tcctccttct tcatgctggc caagtcagca tcattattat
|
89341tacctaagtt tatttctaac acatctcaat atcttcatgc actccctctt gataaaagta
|
89401actgagcata gcaccatcaa taccatcaaa tctgtcattc tcttcccctc tctctgggtg
|
89461ggacaggaag ccaggctgct ctaggaaatc ttccctaaca agcaaagggg acttgcctgt
|
89521cctctcgcat gtgtgatctg agcttgtgtg gatcccagag tgggcattct ggactacttg
|
89581accttgccta tctctccttc acaccctctc atctctccct cctaccacca aaaaacttgc
|
89641atcgtatttc caatctccag acatactttt gaaaccattt atctatctgg tgtgtttatc
|
89701tgtatctagt atgatgtgaa tatgtgattt gtatgtgtgt ctaccactgt tttggtcagt
|
89761ttgtatttct cgtgggtaca gttctatgtg ctcatgtatg tggaacatat gtatactgac
|
89821acatggacct agctccaaat gatctgaaag gaatataatt gtaattgaat atttgcacag
|
89881atatacaaca tacacatgtg atggctgggg gaaatgcatg tgggatttca gtcagcattt
|
89941tattagagaa ggtatgtcat tagtgctgta ttaacaatga atcagcttat ttgtgggtca
|
90001ctgtcaatga ctcctttgca aatcacacat gtaaatattt ctgtctgtgg tctgatgaac
|
90061atgcagtgcc acagtctggg agatgctgag ccatgccctg tgtaggcagc atatgaaaag
|
90121aactgcatga tttaaaagat gctgaccagc ttaaggaaag caatttaaaa acttcctaaa
|
90181aatctagttt gaatgaacaa cagttttcat tttgtgtgtg tgttttttct tttagagatg
|
90241gggtcttgct atgttggcca cgctggtctc taactcctgg gatcaagcaa tcctcctgcg
|
90301gctcagcctc ccaaagtgat gggattacag gtgtgagcca ccgtgtctgc tggccccact
|
90361gttttaaacc ctgattcgac aatcatacat ttaactcatt acctgtcttg ttccttttac
|
90421gacaaactca aagcttttat tttactaaag tatttgggtt aatcttttgc ttttctgtca
|
90481tgttctgaaa tatgtacaat aacagaatcg ctcaaaatat tatctccgtt aaatgttttg
|
90541tggctttagg gagaggtcta acaacatgcg ggaaacaaga aatcaagcgc atccaggatt
|
90601catttataat ctctctcgtt gagtagaagt ccgcatctct cgatattgtc tggttacctg
|
90661catgaagtat tctaaaggag gaaaatagct caaagaggac attcatgtgc actctggctt
|
90721ccagttggcc atttgagtaa gtgatcgcaa ttaactgacg agcggcaggg aaacacttcc
|
90781tggaattctc atctacagac aagaacaaac tggggcgggg cccatcacct tcacctacgc
|
90841gccgggaggg tggcggctgg cgggcggggc cgggctcggg ccgtgacgcc gagagtgcgg
|
90901ggcgcgcggc tgggagcctc gcgcccccgc ccgggcccgc ccccatcccg cccgcataca
|
90961gcccgcatcc cgccggggaa gcgagcccag tccagcgctg cccgtccagt cctcgcccaa
|
91021gatttaaagc ccgcaagttt tgttcttgag accagcgact ttagctccga tgcgggaagg
|
91081aaagccgacc tccgatttgg acatttaaag agctgggctt gaacttcgtg agtttcgctc
|
91141taaactgccc ttgaaatgaa gctggacttg gaggtaaagt cactgggaag ctggcctggg
|
91201gcggggtttc cccctcttct cgtattttag aaacggacag cggcagtgca gccctagttt
|
91261gctgtaagtt tccttacttt gttactgagg cccccagagc tccacgcata agtggtgtga
|
91321ccagaaacct tttaacaaga cccgcctgag cctgcgttag agctcccgct cggaaagtaa
|
91381aagaccatcc taatccgcgg cgctgcggaa ccggtgtccc gtgtgggagg aaccgcggcg
|
91441ttccctgggc gtagggcccg cgaggccagc acagtccgcc tcttggcgga gcgccctggg
|
91501ccggtggttc cgcgcggagt tagtctgtgg tcagttacgt ggtgaaaaca cggctgtgcc
|
91561gcggccgcat ctttccgcgg ccgaggcctc tctgggtggg agtgttggct tcctttccgg
|
91621atcgctaaat ggggaaagtt ctggccgctc ggcgggatac gtctccaggc cacggatggt
|
91681tcgttctccg tgccgcggcc ccgagctggg ctccctgggt ctccagcgcg ggctcccggc
|
91741attgggggct gcgggccggc ccctccgccc cgcccccgcc ccgccgcgcc tcctcggccg
|
91801agcggctcgc ggtctccggc gcgggaggct ccgagtctgc ccactccggg ccgagcgagg
|
91861tctctggagg agaagagtgg cgaggaggtg agggcacgcc ggccctcgcc cggcgggtgg
|
91921cgccaggact tcaggtggga acgcgcgctt gggccggggg cgcgtggctg gcgtggacac
|
91981cggatcgggg cccgccgccc tggcccggac cgcgcacggc ccagcgccgg gaagtcggga
|
92041agccggggag gcctctccca ccgcgggccc cggcagcccg ccctctgaaa gcgcggcgga
|
92101gaaggaggct cgtcccctcc ccggaacgcc tttgttccct ccggcctgcc cgcgcgggtg
|
92161gccagcggct gggacccagg ccgggccgcc gcccaggtgc ggcaggtagg ctcgggggcc
|
92221gggcagctcc ggttggggcg gcttcccggg gcctgcgggt ccccgtccct gaggagctcc
|
92281ggctcctcgg tggcgggaca ggcccgtgcg cgggagccgc gaggcgaacg ccgcgcccac
|
92341caattcggtt gccggccggg ggccccaggc ttgcggccac ccgcctccgg ctggagggct
|
92401gaattcgagt cgaaagcccg tgtcgggctg gaaagaagaa accgccaacc tgagaacgct
|
92461ttcggcgagt tactggcggg ggaaatgggg acagggaagt gggcaggcgg ggagactgca
|
92521gccgcagatc tccctggcgg ggaggtcgtg gccactcttt cctttgactc tgcctcattt
|
92581cattttgaat cctgatgtga cagaggcaat tgcttgcttg gataccatat aggtaaaagt
|
92641aacagttttc aactcgactc ttgactacac cctgtacatt cttggccggt gttggttttc
|
92701ttaggttatg gatcatgtta aaggtacacc gatgtggtaa ccgcacagtg gccgatggtg
|
92761gcctgaggct catatttatg gtaattatct gatgaaagta catccatcag aattggattt
|
92821gtgcgtctgt gcctttattt tgggaaacct tgcctgttcc ctgtggggga tgggagagga
|
92881atgtgaaaag ccgaagttga cccagaaaag gatgattgaa ggtagttgta ttaagtggtg
|
92941gcaccgaaat gattccaccc tgaactttct gaaagggtga ttagtgatca gcagcagacg
|
93001ttataacttt ctcaaaataa atttatggta gattttctat ctggtcacaa gtgaggaggt
|
93061gaaagctgct ttttggggcc aactctttgc ttttaaagca agctaaacgc aataccagaa
|
93121aggtttccat tctgtactta acctgcttgt ccttctcact cttccttatc CtCCCgCaCa
|
93181cgctctgagc attgactgag cactctgagg aggaggctga ctcaggctga cccttcccgg
|
93241ccctgcaagg ctctaaggta gaaccagtgt tatcacagga aaggcccaag ccaaagctca
|
93301gagcagctgt tcctgagaaa gtgggagatg aggatgagta ggaggtagag atgcttataa
|
93361ctgctctgcc cagagaaaac tcagaaggtg cagaagagtt ttcaaaataa agtgcaggcc
|
93421ccatcaagta aaaaatgaaa cattgtattt cattaaaatg gtgatcagtt ttctcttttc
|
93481ataaaagaca ttcaaatggt gagattgtaa aaaaaaaaaa aaagaaaaag aaaactttct
|
93541aattctcaaa aatagaacag cttgaataat aactcatggg ttttgaaatg ggtcatcttt
|
93601taaaatgggt cactttggct agaatcattg cacttggtga ctttcacatt gtaaagggtc
|
93661cagttctttc tgaggcccaa ttgcactaga atctgcattt cagaacacag gaggtatcag
|
93721gaagaaactg ggagaaattc agagggaaat tgtctcttct cagagtaaca aaatgtcccc
|
93781tattcagggg gaattttata tatgctgaag taaatagatc tcagctttga atttttataa
|
93841tacattatgc cttttctgaa atatttccat agccattatt ttaatgcatt gttagaataa
|
93901ccttgtaagg agaggaattc attgtatctg tgttccagaa actgaggcac agtaaattac
|
93961aagagctctg ccctttgata tcgaatctct gtgagcgaag atgtaaccag aacagtgtaa
|
94021atctagaatt actttcctta cggtatgcaa tatctaatta ttatgtatta gtttacatat
|
94081atatagggga tgtaagaatc tttatattta aaggataaga aacttgatca ggtgagatac
|
94141aagatttgaa taaaaaagcg attttttaga aacattttaa ttctacaaat tcagttgctg
|
94201gctttgatat gtaacttatt cagatttctc ttccatagaa ggctttaaca ctagaagcca
|
94261gttctctaca aaagagaatg ttctaccaag tgtgtaggca acaaagccca aaagttcaag
|
94321ttcaaaatac tgttctacag cctaagatcc acctaatatt tcagatttga ctcttttgct
|
94381cctttcctat aacttcctat aactttttca tagtgctcta agcaaagtaa gttcaaggat
|
94441ggactcacct caagtttcct tctcttactt tagaggacca tataatctta tacctgtgtc
|
94501atcctaattg aaatgtattt taagtgcttg tgggaacaag aataacggaa gaccgttatt
|
94561ccattaatgg aataatgggg aacatgagaa ggaccatatt cagtcaatta gggatgatac
|
94621ttctgcctca acagtatttg cgatgtgtta aatggccctt agccatcaga tcagtatttt
|
94681taaaaactcc tacctaatta atgttttttg agaagaagca tattatgagt atagctcagt
|
94741attctaaaaa gaaaaaaacc tgaaaaaaaa atcagccatc cattaactaa cccatcctgg
|
94801taaagctaca caaacagatt ctagagaaag gaaatttgca cagatggaac atctaatctg
|
94861gactgacatt gtcaacaagt tatctcaaat gatcctgaga aaacactggt acatggttta
|
94921gagacaagtc gagctcatgt gactagtaaa tggagaggca cagtatacat ctacttttgt
|
94981tggcatttaa acactctcgg cttttttact ctctttcacc accatcaggt ccagattcca
|
95041gcttgcactg gaatatttat tgaccctttg atagaagagc tacacctgaa acatctctga
|
95101agtcttttta gcatcctatc ctgcccatgg cctactacac agtatgtgat aagttaatgt
|
95161ttgttgaatt agttaaatat acgtattaac ctactttcag ggctgcccgc tgtaatgcct
|
95221agaatagggc aggcacttaa taaatggtag ttaacttaga ctaaatgttg atccaccaag
|
95281acagaaacat gttacatata cctcttgttt tacaccatct tctacttttt gtacctctgt
|
95341gttataaacc ctctatcaag tgttgcttct aaagacaatg tccagaatgg gacgtaggaa
|
95401ctgccactgg gcaacaggca gacactgggt tatatcgtca tcctgtttct gaatcctggt
|
95461ttttcttatt attattcaac cacagctaaa ctttctgatc tccttttttc cgttttttcc
|
95521ctttacccta acttctagcc aaactaagtg atttgacatt tccccactca agccacaact
|
95581ttttctctta tgtgcttaaa aaaaattcct gcgtagtctc tcttggaatg tcttattcct
|
95641tgctccctcc acttcaccct tttttttttt tttttttttt ttttttgaga cggagtctcg
|
95701ctctgttgcc caggctggag tgcaatggtg ccatctcggc tcaccgcaac ctccgcctcc
|
95761tgggttcaag cgattctcct gcttcagcct cccgagtagc tgggattaca ggcatgctcc
|
95821accacaccca gctaattttt gtgtttttag tagagatggg gtttcaccat gttagccagg
|
95881atggtcttga tctcccgacc tcctgatccg cccgcctcgg cctcccaaag tgctgggatt
|
95941acaggcatga gccaccgcac ccggcccact tcacccttta agccagttga aatgctcctt
|
96001gccctactcc tcccttctcc ttttctttct cccatccaag tactaaccag gcccaaccct
|
96061gcttagcttc tgagatcagc caggatcagg tgcattcagc ggggtatggc tgtagacttc
|
96121tctttctgag ctgtgtcttc ctcctttcct ccccaaaccc acatttgaat tctgttctag
|
96181ctcctgctca tttgccacct ctcccacaaa gccttcccca gtttccatct tctccctgct
|
96241tccctcatct cagaggaaag ctcttcattc acagagcacc tggtttgggg tccatagttt
|
96301gttgtccctc agtatccttg gggaattagt cccaggacac cacccccccg cccctgatat
|
96361ccatgcatgc tcaagtccct tatataaaat ggtacagcat ttatattata acctatgcaa
|
96421tattcccatg tactcttttt ttttattttt atgtgtttag agatgggtct cactctgttg
|
96481tccaggctag agtgcagagg catgtagcct tgagctcctg agtcaaatga tcctcctgcc
|
96541tccgcctccc aagtagttgg gattacaagt atgagctacc acacctggcc catgtacttt
|
96601aaatcatctc tagattactt ataataacta atgcaatata aatgctatgt aaacaattgt
|
96661tacacggtat tgtttagtgc ataatgacaa gaaaaaaatg tgcatgttca gtacagacac
|
96721gaccataaat ttttttttca aatgtttttg atctgtagtt ggttgaatct gaggatgcgg
|
96781aacccatgaa cgtacacgac caactgcata tgggtttcta ataacagatt tgtggatgaa
|
96841gcccacccaa cataatgcaa catttcaaat gtatcttagt cagtttttct ggggcaaagc
|
96901cagcctaaca aatctcaaga atgtttgaaa aattctagct tgagtgaacg ttgttcttct
|
96961agtgactcaa ataaagcagt cattgtgtct gaggagtcct agtggggtgg caggggtggg
|
97021gctaggagta gtggctgttt gtagcatgtt ttatatcaca ttaaagggct gggtatgcat
|
97081tttaggcaat aattcttact cttattgata ggagaacttg tattttttat tcatctacct
|
97141tatgatggat aactggttta catctcttca tcaggtttac ttcttacgtg tcattttatg
|
97201agctgacttt gaatatatct tcagattttc cctgccttta cacatgaaaa cggttttgat
|
97261acagcttttt cattagagaa tggcagcttt tccaggccag ggtgtctgtg tctgactcct
|
97321cgcctttcat tttacccaat acttgcttaa aacatcctcc ctgagtccgg tacttttttg
|
97381cctcctctcc ttccttccac cccacctctt tttgtcaccc tcctgcgact ttggatctcc
|
97441atccttggag tccctgaatc ttttttgtgg ttgaaagact acacccaaag gacacagact
|
97501gatgaggtca cttctgccca ctgtctagta ctagtgagac caagaagaag aaggagggaa
|
97561aactgaaatg gaaggtttga aaaagagtgt gttagtgaag gaagtaagaa cagtgctaac
|
97621agaatgcagc aaaacagaaa tgacttcaca cttctggcag tgaagcaaat tctcatccat
|
97681cttgggttgc ttctcttgac cctgcccacc tcctcccctg ccctcccctc ccgatgagaa
|
97741ctgcaggaac acctgtgccc atgccaagga aaaagggcag gtgaggaaca cagggatggg
|
97801gctgggactc acaagctgct ctaagctgcc acagggtctg gaatttgttg acattacatg
|
97861gttaactcgg tatctcgatg cctcagtatc ttctgcaaaa tgtggaggga gatcctttct
|
97921tcctcaaagg ttgttgtaag gcttaaagag ctaccacatt cgtaaggcat ttggaacagg
|
97981gcctggtata tagtagacat acccatggta gtaactgttg ctagactggg taaaaggaga
|
98041agtttcttaa gtaggcaaga aaaaaactga caacagttat atttaaaaga gcaagcaacc
|
98101gtgtcagccc aaacaagtgt gttgcaagaa tgagcacaga gggccaagct cagaaaagcg
|
98161agtgtttgac ctctctgaga cctcctttat atgtcagctt ttttatttgt ttcaaatttt
|
98221gcataatcaa actggttact gggaattatt gagttcatat aacttcccta aaatctaaga
|
98281ataatctata atcccatgcc accagtcccg ttaataaaga cttagggtct gtctttaccc
|
98341atttgttcat ttgaaattcc ccgtctttac ttcccccata accaggaaac agatctacac
|
98401ccatgtttaa cttataaaga gatataagtg agtttacata ggtggagatc ttgtacctgg
|
98461attcacattg taggttttat tacccagctt tcccctctat cccaaagcca tgattgccat
|
98521agtggaattt aaagtctttg gactaacact gaatcaagaa ctaactctac aaatgtattc
|
98581tctgcaggag gataagaatt ccaaatggct tctaattgtt gcccatggct tgaaataaag
|
98641ttccatatag ctaaagcccc agcacaaaaa cacttgaaga cagccattag gtagaatttc
|
98701ttttcttttt tagaggtctt atattggaaa tgtaacagtt gcaaagatat ctaatgtttc
|
98761accttaaaat gtgagttata aattcacatt tcacattgcc tccttcctcc ttgagcaaac
|
98821agactaggca attagtacca aatagtaact agttatattt cttaacaccg attattgtaa
|
98881gtaatttatt aagaaaaaat ctaggaagat caaattatag cttttccagt aaatctgggg
|
98941ctttttattc ctgatctctc tcaacaaggc agtttggctt ctgaagattg gtcctagcta
|
99001tacttaacag gaaacagatg acgagaagaa gccaggaaaa aatacttgga atatagaaca
|
99061aaatgcagca taaagatggt acagaagatt ttatctttct ttcctttagt tatgtgtgga
|
99121caggaactaa aaactctccc acgtgggact ttattaagta ataaaagttt aaatgtaaaa
|
99181gatataaagg aatgaggata taaaggaaat ttttttaaaa actgtgactc accggaggag
|
99241ccttatatag tctactttct aagcatatca cttttaaagg gatcattata ttttcatgat
|
99301gcatggggat attccaagta ttaaattgat tttttaaatg aagaaaatta tcagttcagt
|
99361cttgttttct atgtaggttt cactacagta ttttatttcc cccgcaagga aaaaaccaga
|
99421gctagaatgg aatgattaaa tttcttagtt ttcttctaat ctgttagtct ttccattaaa
|
99481ttatactgcc ttcttatata gaatttctgg gtttgttctt gttttggcaa taattgaagt
|
99541aagagaggat gattttatgg tagaggtttg attccattct agattggtgt ttttcagcta
|
99601tgtagaacac aatccattca tggttcagac aaccgtttta ggaggttttc atgtccagca
|
99661ttaaaaaaaa aaaaaaaaga atagaattgg gcattcatat atatatatat atatgaatat
|
99721ttattaataa aagtttaaaa gatataaagg aatgaggaat gcatatatat tatatatata
|
99781tataccaaat taaagtatca taatactaat acaaggatta gtatcgtttt atgatacttt
|
99841attatataca ctaagggtta gtcttgtttt atgatacttt attatataca ctaagggtta
|
99901gtcttgtttt atgatacttt attatataca ctaagggtta gtcttgtttt atgatacttt
|
99961aggttggtat acatacatat actaagaatg cagacatgtc catggaagtt ggcaatattc
|
100021agcccccagc aggccccagt cagcaggaca gggattaggg gagtcaggtg aggcagggct
|
100081gtataagtgc agggttggag cctgtcttgg tttaccgttt tgacattttg ttcactgtgg
|
100141atttttttca gtaactttga ttttttaaaa atattgcatc aaaatattat actgactacg
|
100201gagtttttgg taccccctta aattgtgcac ctaaaataag tggctccctt gtctccccct
|
100261agtcccggcc cgatcagtat gttttataga gggaatggtg agtgttgggg aactagggag
|
100321cccatgagga ggcggcccag aaggggagga ggagctgatg gtgtgtctga tgtctcctcc
|
100381tttctctagg aagcagacag gaggtgaagt cttcagggtg ggggggacag agcctgggag
|
100441ggggagattt agcatggccg ctgaagagac tgggaaaggg agaaggttcg ggacaagttc
|
100501aggaacagtc acgtagcact gaaaactgct caaagctaga tagtgccatt tgtggtgacg
|
100561ctgcctgcct ggtaagtccc atttccccag cagccctgga ggtgtcatag gaacaggaag
|
100621atgggagggc gctggggtct ggggttgttg gggtgggagg gcaaaggtgt ccaatgattc
|
100681tgcatctgaa acgggggagg tgtgtgagga agaaaggtca ggagactgct gggcagggtg
|
100741gggtggcaga aggttctcga tgaatattta gaagttgcag ctgaggagtg agtgtactat
|
100801agagtgagta tcctggaatt tgaggtctca gaagaaatgc agttctcagt gaagccatgt
|
100861aaacaacttc ctggctgata aggtgtcttg agtgttggga gatcacatga tcaaaatggt
|
100921atacacacca taaggtgtcc ttagacttga gtgtggtgta agtctactga ataaaatgca
|
100981gaaatacagt tcactgttgc ttttcttcct ggaaattgcc ctccccaacc tcaaaccagc
|
101041ccccaagtgg ggcagggtcc atctttagac cctcctgtag cacccagcac aaccctaact
|
101101atatggtcaa tgtctctctt ccccacttag agctccaaga ccagggcctt gtttgtcctg
|
101161cttacccact ctacccattt gttaacccca tcttaatttt ctgatgaatg agcccttttt
|
101221tcattgactc ctcctttctc tccttctccg gagtttattt ttcctccagg cccattgctg
|
101281tctctccacc tagagagctt atccacattc atgaaattag tcatcttcat gctcagagta
|
101341cccacctgga tctctccagt cctgtctaac tcgtcttaga ttattacccc ctggacatct
|
101401gtaccttctt gtctctccat cgcctcgaac tcaatgcgag tctaaaatca aatactcctt
|
101461cactcctaac tcaggaaacc agttttccct cccttgttgg taatgcttga aattagctct
|
101521tacttctctt cttcctcctt tactcgccat cccaggtcat tcatcaggtc ctgctaggtc
|
101581tttgattttc ttgaaagggc cttctttatg ccttccttcc gtccccattt ccaccaccct
|
101641cgactaggcc ttcctcacct catccggcat cagtgtgagc ccttgagaaa ccagcgtcct
|
101701gatcttcagg cattctgcat ttcaccccat accaccatta gccagtttaa tccctcttgc
|
101761tcaaacttaa taaatactga gcaagggagt tactataaca aacaaaacca gaaatttcta
|
101821tgacttcctg ctgctttctg taccccccta agactcctct acctgatttt caaggttctc
|
101881cataagcagg ttcccacctc tctgctttca aatcttctat ctgccataca cagttcttgt
|
101941ctaaaacaaa gattgttcct actcctgcag ccacctaaat cctagtcgtc ctcaggccct
|
102001cctaaaatcc tgactaatcc aacccccacc gatttctcta ctagtcccag agacttccct
|
102061cttgtgcctg gggttggtgt catgcagaca cactgtacct taccaggatt tgcccattgt
|
102121tgtctgtggg aactatgctt tcatgtggga actacgagtc ttgtcacaaa tagagtgtaa
|
102181atgctttgag attggagact gtaaaatact tcttcatgat ctcccactgt gtctggtata
|
102241agaacccgca gagtaaatac tcatatactt gtaggattaa ttgaaacaac tggagactga
|
102301ggttgtttaa cttgtactta gaagtgtgga cctccccatc ttgattaaaa cttcaaaacg
|
102361gatagcaggt ttcacatatt atctcagcat cacaaaagta gactcaacaa agaaatgagt
|
102421tgacagcagg ggtaaggttt acaacaatca gggattattg cagggaaact tgtagccttt
|
102481gggtgttcta actagttttt tcccaaaaag tttaaagagc tctcttgtga aagaatattc
|
102541ttatgagtaa ctgaggggca cggctcctag actgaaaagt atttgggatc tgtcacctct
|
102601tttctgatgt tcctacttct attctttatt cttctgacta cctctattag aaaagataat
|
102661actaagaata cctgtccctt cttctcagtc caaatagaag caaacccagg ttgtatctga
|
102721gatatctgca tattttcttc taagcaattc tttgtcctct tctctcccat gctttttcta
|
102781tttcctattt tcagcaggct ctgaagtcat ttataatttt tactgcccct cggtgacatt
|
102841acatggatat tcatccctga tttgcagatt aaagcaccga atcagagtga ggtgagggtt
|
102901gcccaaggtt acacaataaa tctggcccca aacaggggta acccttgagt ttctagtctg
|
102961ttgattggcc actgacccgt gctgcaggca cacaaaggaa gctgcaccca cagcagtctg
|
103021ttgtggatgg ttgctgagct gcgcattcgg cattgggctt gctttgtttc ctgccaggcc
|
103081cagcattttc ttctaccaga tcggcaggct tgtgggcttc ttcctaggtc cctcccctgc
|
103141actctgaata ggaaagctgg aagctgtgct ttagagaagc tttaagacgc cgaaagaaac
|
103201cagaagagtg agcgccagtt gtatgtgcgt ggtctccatc cgcaaagccg gagctgggcg
|
103261caacagtgtt gacttgtaat tgatcaattt agatcgggcg caggccgggg gagggcagtg
|
103321cttttgattt aggctgggaa aggcctccta gtgactatgt tcaatttgga ggaattcaga
|
103381tgttcttttg ttatacaagt gaagctgtgt aatacaaatg aggagtttta cttttcctaa
|
103441atcttcccct tatcattcaa gtattgagga gttttacctt tcctaaatct tccccttatc
|
103501attccagtat tatcagtgag atctggttgt gatttatgta aatggtggct aaaaaattca
|
103561aactactgag ggggagaatt ctcattttac agcttcacat gctgtgctga actaaataag
|
103621tagcgtggga tgttggcttt gtgacaggtc ttttgtcatt tttcagaaag cattttgact
|
103681tgttgatgtc aatttggaac agctgaaaaa atacaggaaa ataagataaa tacgtacatg
|
103741ttgagggtgg ggacaaaatg aaggttctga accagctgcc ggcttacagt agccatataa
|
103801gcaacagcag caatgcacca acctggtgag taataggcct gattcactgg agagatacta
|
103861gcacctttaa tgagtcagat agatgcacaa tgggtgtggg agcagttgga cttgtgggca
|
103921caaagtctag caagaagctc agacttgcaa acaactgtag gacgtgcaaa gcaagctggc
|
103981attggagctt gccgggcaca gctgctcagg aataggcagc tggttttccc tttgatccct
|
104041gagattccaa aggttacttt cctctttgtt cccttcccag ggtcaattag agtagaaact
|
104101gcagatgctt ttcagttgag aattttccta gaattctcaa aaatgtgtat gctggcttaa
|
104161aatctgccat caagaattct gttaccttgc tttaagcctc cagttccttc cagatgtatg
|
104221gtggaggagg ccagagggcc cttgttttgg ggcttcagag gatggttgtt atctggatga
|
104281gcactgtgga aagactgaga gagcaactga gagaaagtgg gcccctgaat gaaagtgatt
|
104341tcgcaaattt taggcagatg ccaccatcag aaactgatat tttctgacgt ctttctcacc
|
104401ttcctctaga gcattcagtc cagaaatgac cagcctgtcc aaagggggaa attactgata
|
104461ttgatctgtt ccttagagca gtgtttcagt cttttttttt tttttgagat ggaatctcat
|
104521tctgtcaccc aggctggagt gcagtggcac gatctcggct cattgcaacc tccaccttcc
|
104581tgattcaagt gattctcctg cctcagcctc ccaagaagct ggaattacag gtgtgcacca
|
104641ccacacccgg ctaatttttg aattttttat agagatgggg tttcaccatg ttgccaggct
|
104701ggtctcaaac tcctgacctc aagtgatcct cctgcctcgg cctcccaaag cgctaggatt
|
104761acaggcgtga gccaccatgg ccggccttca gcctttgtga tattaaagca cagcaacaca
|
104821tttcccatta cacccctgaa cacacacaca cagaaaaccc aaaagtttca caaaatgatt
|
104881cttgctctta ctactctcag tacactctgt atttaaaaaa aaaaatgctg gttgtggctt
|
104941cctaagtggt gcgtgcagtt ttcaaatcaa tgcccttggc gataaagtgt gccctatact
|
105001gattatctct ggacaaagtc tgaatggggc ttggctctaa tctctagtcc tcattggaca
|
105061ttttacatac ctggcctttg cctccaccct gatgtggagt gatcatgggg gtgggaaata
|
105121tagctggatc cgaaagctct gaagtgggga tggaggtgtc acagctgagg ctaggcccat
|
105181tctgcagggc actcagtgtg tacagttggt tttctatcag gggtcaaccg gcggggggac
|
105241ttgagaacag atctctgggc acaaagcagg gcctttgccc tggggcttgc tatgtggctc
|
105301agcctacacg gctctctccc cgtcagtcct gtccaaagcc caggaaacta atgtaccacc
|
105361cccgaggaag agagcctacc tttccatcca aggaagtgtt ttacctgtgg taagcacggg
|
105421ggacagaatt cttgaggaag gagggtgctg cgtcccagtg gtggaggaaa agagaggacc
|
105481tggtgtaagc agccatggca tggacctcat ccgaggtggc acctggctag ggtcctgacc
|
105541tccaatcctt ccccagtaac catcactttg agtaaacagt ggctccaccc ccggcatggt
|
105601tctttgcacc aacatttggg gaatgcctac caggggtcac acactgagct ggatgctgag
|
105661tgtagggtgt ccacaacatc gtgcctaaaa agtctctgta tggggtataa gaaggtgctg
|
105721gggcaataca gatgagatga gaagcatctt tcagggaatg ggttgatccc aattcaggct
|
105781tcccagagaa ggatgtctgt agacttcata ttagcaaggg aggaaggtag ccaggccaca
|
105841ggactgctgg tgtaaagacc agggcatatg aaatggcaag tgtgactgtg ctttcagcca
|
105901ataatttggt attgtcaaat gatgggacca aacagctgga gaggcagatc ctaaagggtc
|
105961ctgtgggcca ggctggactt catcttgtca ctaactaatg gagaggctct gaaggagtta
|
106021aaagagctca gtttgtctcg tggttaaatc caagttttac aaaggtcacg ctgactgtaa
|
106081agtggaaggt gggctggcca ggggatcatc tagtctgggt gagaagtgat gataacatga
|
106141aggggtgaag agagatttag aagaagtgat tcacaggatt aaacatttaa ataatggaag
|
106201tggagaaaat ggggggggcg gttccagatt tcaggcatag atgaaagaag tgcagttagg
|
106261cacatgtaaa gagaaacagg aacagcaggt tttaggggag aagataacag aatgggtgag
|
106321aaatgacact tgagtaccct agtgtgctag gtaatcatct gtctacttcc cttcatttgt
|
106381catgtatatt cccatttaat ttgcataaag acttcgagtt aaacggtctt accccaattt
|
106441gtcaaatttc tgcgcatgat atggtacaag aaaccgtaag tggctaaggc ggcattggtg
|
106501ttcaaattgc ctgactacaa aggcagtgct tgttggctac attctgttgc ttcccagttt
|
106561agaacatgtt acattgaggc gcctgctgca tttccaaata aaaaagtaca gaaagaaggt
|
106621ggctgtataa atctggggct cacaaagtaa ttttgattac tgagagtttg ctttcaagga
|
106681gcaaactgtg actccttgat tatgaacctt aatttaaaaa aaaagaaaaa agaagtctta
|
106741ctcttattcc tgccttgtct ggggcaagcc ttaatggatt tttactgctg tgaattttct
|
106801tttcattgaa gattttgcct tgatctatgt atctgctttc atcctgacca tattcaagtc
|
106861agtatattca tgaatgtacc tgtttgtgaa atttgaactt aagtatacac gattatagcc
|
106921gtttgggaag cttttttttt ttttttttta agagtaggag tagaaaaagg tctctgtact
|
106981ctgaatggga agacagtgta aagcaatttt ttcccttttc ctgtcctcct ttaaaaaaaa
|
107041taaacagccg tatgcctctg ctaagtacta actacctcat caccttttgt gcagacaggg
|
107101caggttacat ttggttttaa ggaattagga atatgtttct ttccagcacc ttagtaaccc
|
107161acgcgattgt gattcttttc tcttcttgac tgtgataggt ggcatggaat attcacatgg
|
107221gagagccgca tgaggccgcc caccacgctt cctgaaggat gcccgtgtgg aagaattttg
|
107281acgtgccagt gtcctcgttc tacagggtgt tccattcttc cgcaatctca gaaaaatggg
|
107341actaaaagaa actattttgt aaaataagaa gacttccatt tttaatgacc aacatgtatt
|
107401aagatggaca cctactctac gaaacacgaa gttctatggt ctcgaagaag cccgtgcctg
|
107461tttaaaactg atcctaacta aaaacagact tgagtggata tgagaatgtt ggttagtggc
|
107521agaagagtca aaaaatggca gttaattatt cagttatttg ctacttgttt tttagcgagc
|
107581ctcatgtttt tttgggaacc aatcgataat cacattgtga gccatatgaa gtcatattct
|
107641tacagatacc tcataaatag ctatgacttt gtgaatgata ccctgtctct taagcacacc
|
107701tcagcggggc ctcgctacca atacttgatt aaccacaagg aaaagtgtca agctcaagac
|
107761gtcctccttt tactgtttgt aaaaactgct cctgaaaact atgatcgacg ttccggaatt
|
107821agaaggacgt ggggcaatga aaattatgtt cggtctcagc tgaatgccaa catcaaaact
|
107881ctgtttgcct taggaactcc taatccactg gagggagaag aactacaaag aaaactggct
|
107941tgggaagatc aaaggtacaa tgatataatt cagcaagact ttgttgattc tttctacaat
|
108001cttactctga aattacttat gcagttcagt tgggcaaata cctattgtcc acatgccaaa
|
108061tttcttatga ctgctgatga tgacatattt attcacatgc caaatctgat tgagtacctt
|
108121caaagtttag aacaaattgg tgttcaagac ttttggattg gtcgtgttca tcgtggtgcc
|
108181cctcccatta gagataaaag cagcaaatac tacgtgtcct atgaaatgta ccagtggcca
|
108241gcttaccctg actacacagc cggagctgcc tatgtaatct ccggtgatgt agctgccaaa
|
108301gtctatgagg catcacagac actaaattca agtctttaca tagacgatgt gttcatgggc
|
108361ctctgtgcca ataaaatagg gatagtaccg caggaccatg tgtttttttc tggagagggt
|
108421aaaactcctt atcatccctg catctatgaa aaaatgatga catctcatgg acacttagaa
|
108481gatctccagg acctttggaa gaatgctaca gatcctaaag taaaaaccat ttccaaaggt
|
108541ttttttggtc aaatatactg cagattaatg aagataattc tcctttgtaa aattagctat
|
108601gtggacacat acccttgtag ggctgcgttt atctaatagt acttgaatgt tgtatgtttt
|
108661cactgtcact gagtcaaacc tggatgaaaa aaacctttaa atgttcgtct ataccctaag
|
108721taaaatgagg acgaaagaca aatattttga aagcctagtc catcagaatg tttctttgat
|
108781tctagaagct gtttaatatc acttatctac ttcattgcct aagttcattt caaagaattt
|
108841gtatttagaa aaggtttata ttattagtga aaacaaaact aaagggaagt tcaagttctc
|
108901atgtaatgcc acatatatac ttgaggtgta gagatgttat taagaagttt tgatgttaga
|
108961ataattgctt ttggaaaata ccaaatgaac gtacagtaca acatttcaag gaaatgaata
|
109021tattgttaga ccaggtaagc aagtttattt ttgttaaaga gcacttggtg gaggtagtag
|
109081gggcagggaa aggtcagcat aggagagaaa gttcatgaat ctggtaaaac agtctcttgt
|
109141tcttaagagg agatgtagaa aaatgtgtac aatgttatta taaacagaca aatcacgtct
|
109201taccacatcc atgtagctac tggtgttaga gtcattaaaa tacctttttt tgcatctttt
|
109261ttcaaagttt aatgtgaact tttagaaaag tgattaatgt tgccctaata ctttatatgt
|
109321ttttaatgga ttttttttta agtattagaa aatgacacat aacacgggca gctggttgct
|
109381catagggtcc ttctctaggg agaaaccatt gttaattcaa ataagctgat tttaatgacg
|
109441ttttcaactg gtttttaaat attcaatatt ggtctgtgtt taagtttgtt atttgaatgt
|
109501aatttacata gaggaatata ataatggaga gacttcaaat ggaaagacag aacattacaa
|
109561gcctaatgtc tccataattt tataaaatga aatcttagtg tctaaatcct tgtactgatt
|
109621actaaaatta acccactcct ccccaacaag gtcttataaa ccacagcact ttgttccaag
|
109681ttcagagttt taaattgaga gcattaaaca tcaaagttat aatatctaaa acaatttatt
|
109741tttcatcaat aactgtcaga ggtgatcttt attttctaaa tatttcaaac ttgaaaacag
|
109801agtaaaaaag tgatagaaaa gttgccagtt tggggttaaa gcatttttaa agctgcatgt
|
109861tccttgtaat caaagagatg tgtctgagat ctaatagagt aagttacatt tattttacaa
|
109921agcaggataa aaatgtggct ataatacaca ctacctccct tcactacaga aagaactagg
|
109981tggtgtctac tgctagggag attatatgaa ggccaaaata atgacttcag caagagtgac
|
110041tgaactcact ctaaggcctt tgactgcaga ggcacctgtt agggaaaatc agatgtctca
|
110101tataataagg tgatgtcgga aacacgcaaa acaaaacgaa aaaagatttc tcagtataca
|
110161caactgaatg atgatactta caatttttag caggtagctt tttaatgttt acagaaattt
|
110221taattttttt ctattttgaa atttgaggct tgtttacatt gcttagataa tttagaattt
|
110281ttaactaatg tcaaaactac agtgtcaaac attctaggtt gtagttactt tcagagtaga
|
110341tacagggttt tagatcatta cagtttaagt tttctgacca attaaaaaaa catagagaac
|
110401aaaagcatat ttgaccaagc aacaagctta taattaattt ttattagttg attgattaat
|
110461gatgtattgc cttttgccca tatataccct gtgtatctat acttggaagt gtttaaggtt
|
110521gccattggtt gaaaacataa gtgtctctgg ccatcaaagt gatcttgttt acagcagtgc
|
110581ttttgtgaaa caattattta tttgctgaaa gagctcttct gaactgtgtc cttttaattt
|
110641ttgcttagaa tagaatggaa caagtttaaa tttcaaggaa atatgaaggc acttcctttt
|
110701tttctaagaa ggaagttgct agatgattcc ttcatcacac ttacttaaag tactgagaag
|
110761agtatctgta aataaaaggg ttccaacctt ttaaaaaaga aggaaaaaac tttttggtgc
|
110821tccagtgtag ggctatcttt ttaaaaaatg tcaacaaagg gaaaataaac tatcagcttg
|
110881gatggtcact tgaatagaag atggttatac acagtgttat tgttaaaatt tttttacctt
|
110941ttggttggtt tgcatctttt ttccatattg ttaattttat accaaaatgt taaatatttg
|
111001tattacttga attttgctct tgtatggcaa aataattagt gagtttaaaa aaaatctata
|
111061gtttccaata aacaactgaa aaattatcat gagatgtgta tttaaacttt ttcatgaaca
|
111121ttgcttatat aatcattcct tctgtcttaa tgtactacat ggtcttagcc ctgttcctat
|
111181aggattatca tgttctctgc attatagagc cacctaagat gtactttttg ttaaatgact
|
111241catgctggaa tatctggatg gggagatgtt ctttcctaat gtagtcatgt gccacaaaat
|
111301gacgtttcgg ttaacgatgg atcacatata tgatgatagt cccatgaaat tgtaatggaa
|
111361ctgccctata caggtgtacc attttttatc ttttatttca gatttttact gtaccttttg
|
111421tatatttaga tgtgtttaga tacacaaata ctttccattg tcttacaatt gcctgcagta
|
111481ttcagtacag caacatgctg tacaggtttc tagcccagga gcaataggct ctaccatata
|
111541tctaggtgtc tagtaggcta ttccatctag gttctcgtat gtataacctg ggatgtttgc
|
111601acatcgatgt ggtcacctaa agatgcattt attggccagg cgccatggct cacgcctgta
|
111661atcccagcac tttgggaggc cgaggcaagt ggaccacctg aggttaggag tttgagacca
|
111721gcctggccaa catggtgaaa ccccatctct actaaaaata caaaaatcag ccaggtgtgg
|
111781tggcacacac cagtaatccc aactactcgg gaggctgagg caggagaatt gcttgaacct
|
111841gggaaaggga ggttgcaatg acctgagatt gtgccactgc tctccaacct ggacgacaga
|
111901gcgagactgt ctcaaaaaaa aaaaaaatgc atttctcaga acttatcctc attgttaagc
|
111961aatgcatgac tataatctgt tgagagaggg atgaaatcac ctgtagttat agcgctttaa
|
112021gataccattt gaaaaggtta cgttttcctt ttctttgaca cggttagctg tctgaaatac
|
112081agtcaatttt aaccctaatc tcttaatatc aggaatgccc ttacacctac tttggagtgt
|
112141ctggtgcttc gatatagttg catgtaatgt gctctcatct gtttttacct gattcctgct
|
112201cagttcttca catggcatat tgtgtaactc aatctatatt taaaacttgt aagcatccga
|
112261attatttgtt tatggtagaa ctttttactt gcaagtcgtg gtaggagtgt ttgtagttgg
|
112321tactaaaatg tgatgacttg gaagaattaa ttaatgacct atatttgggg actttaattg
|
112381gatgctatag ctgcaatgag aatagaacca gagaactctt gatatgcaag gttattcatt
|
112441ctgtgataat aatgagagga atattcgatg tctctttgag tcagttttcc ttccgatcac
|
112501ttccgcattc tgcagtgaca caatccttaa tcatagcttt cattacaata ttcctttact
|
112561ccagacctca aagactcctc actgcctcca gcatcaaatc taaactcttc tacctggttt
|
112621tcaacgccct acgtaaactt ttcctccttc attccctata gcttggtttt ttttttttta
|
112681tcactgccac tattatctat cacaaatgtc aatcatgacc ataccttgct taagttggtt
|
112741tcccttgcca agagcactgt ttttcctata cctgttgaaa ttttggaaat ccaattctac
|
112801ctcctctctt cccttaagca tctcttcctt cccttctccc caaatttata tttagtcaca
|
112861tatattatcg tactacctac taatcattcc atgtgttttt ttacgagctg taagttctga
|
112921aggcaaccat gccttgtaca gtgtccactt agggttctga ataattaatc atctccccaa
|
112981aatctgaaag ccttctatat accaagcaaa tttgtttagt tatgcagcaa aactcaaatc
|
113041tataaaatca aaaaggaata aggaaataca gattaaacag ttgcagcaaa gactggtgat
|
113101cttaaggtat ttagtcaaag ctggtggtag aacaaaaaca gtagtcttac agattctacc
|
113161tcttgattaa ctcagtggct aattttgcct tttctcaaag ttcttttgca agaacataaa
|
113221gatatttttg tttctttagt tgagtgctgt aactttattc ctttgtgttt ctcataagta
|
113281tgatttggca gtctgccata cgttttttgt tttttttctt cctctttgag acagggtttt
|
113341gctctgtcac ccaggctgca gtgcagctgt gtgatcacag cttagctcac tgcagactta
|
113401gcttcctggg ctcaagcaat cttctcacct cagtctcctg agtaactgag actacaggtg
|
113461caccccacca catcccgcta aatgttttaa tttcttgtgg agatggtgtc ttcactatgt
|
113521tgctcaggct ggtcttcaac tcctgggctc gagcaatcct cctacctcag cctcccaaag
|
113581tgttggaaag tgttgggatt acagacctga gccaccacac ctggcctgtt ataagttaat
|
113641acaataattc atcaactaac ttaaagaaca ctaagactct tacaaaagta ggtatgagtt
|
113701ttagtaaaag tctcaaaaga taaactgtca cttaaggaaa actagagaac atatcattgc
|
113761caaatggtgt ttttcagaga ttataccatt caacgcccac atgctgaatt gggccattca
|
113821ttataactcc aggaacatgg caatcagtaa gagcccacat gtttctttga atacaccgta
|
113881agtgaaagaa tataaagtag tctagttaat attatgttta atcaaggagc acattcctaa
|
113941agatgtttgt tcattcattc tacagacatt tttcagaggc ctgctaagag tcaagcatta
|
114001tgatagacgc catggataaa agcttacaag tcaaccagcg tgggtataaa taatgtgact
|
114061agcactagaa caggtatcat gatggggatt ctgagtataa atattttttt aaaataaatt
|
114121tccccgtgtt atttttggct tttacctccc taatttaggc tttctaaatg gcacagcatt
|
114181tctgaggatg caaacacctt tctacagagc aaaaacagca tttgtataaa tttgtgtctt
|
114241tggggaacca agagacttta aatgtgttta aaccaataat tcagtcaata tcaacattag
|
114301cttacatgta atattctctt gatagcccaa ttttttaaaa cactgtattc ttagaagttt
|
114361ggtttctaag atgtcacttt aagctctttt gcttgttgct tttgtgggat ccacaaattt
|
114421tgttctcagg tacataaatg aaggttagta tagaggataa atattatgat tcttatctgg
|
114481gaaagacagg tgctgaggtg taaaagagag gatcctcgcc acccatgccc cgcaccccct
|
114541cgccccctgc acccacggat gtgcagtctt acctgcgggg ggaaaggtct ccgagcctgg
|
114601cctgctgctc cagctcaggg ttcccccttt catgatggct ttcaaagatt tcttcactct
|
114661gaagtgaaag aaattttggt aagatttgat attgtaggga cctcctaatc tatatttttc
|
114721tctctcccaa tttctgtgtt tgattttggt tttgagtctc tcgataagca aaatatccag
|
114781tttctcatgc cgctttctca ggttttcccc agccactctg gatccattat ggtttgccct
|
114841ttttggcttc ctttaggcac actaaaaact ccttcccaaa agcaggtatc ggccgggcgt
|
114901ggtggcaggc gcctgtaatc ccagctactc tggaggctga ggcaggagaa ttgctcgaac
|
114961ctgggaggcg gaggttgcag tgagccaaga tcacaccatt gcactccagc ctcagcaaca
|
115021gagcgagatg ccatatccaa aaaaaaaaaa aaaagcaggt gtcctttccc cttaatcatg
|
115081aagggctatt catactttac tgccccaccc ctattgattc ataagaggac agtaaagcga
|
115141tcactgcatt caacatctcc tttttttttt tcttgtaaga aatcaaggtc tggaaaagtt
|
115201gcactcgccc tgagaccaga aagtgctgga ggcagagatg aagtaagccc agtgtaggct
|
115261ttcacagatg cgtgataaca agtctaacta aagaagtacc tgggatacta gttttgccaa
|
115321ttcagctcta aaacaatatg gcaatcttat attccaaata tatatatata tatttgtatt
|
115381tatagtagag atggggtttc accatgttgg ctaggctggt cttgaactcc tgacctcaaa
|
115441tgatccactg acctcagcct cctaaagtgg aggaaacata tatatatgtt ttccttttaa
|
115501aataggatgt cagtccaata agaatctaaa ttttagttcc ctctaatata tatatctgac
|
115561tagggaccag ataatatttt tcatgtgtca atatataaaa gttggccagg tgcagtggct
|
115621catgcctgta atcccagcac tttaggaggc tgaggtcagt ggatcatttg aggtcaggag
|
115681ttcaagacca gcctagccaa catggtgaaa ccccatctct actaaaaata caaaaattag
|
115741ccgggcatgg tggcaggcac ctgtaatcca gctatttggg aggctgaggc aggagaatca
|
115801cttgagcctg ggaggcagag gttgcggtga gctgagattg caccactgca ctccagtctg
|
115861ggcgacacag tgagaccctg tctcaaaaga aaaaatatat atatatatat attttttatt
|
115921atattgttta ttaaacaaat aaaaataaaa gatatctcat cagttacgat gtaaatgaaa
|
115981aaattgtgtg tgtgtgtgtg tgtgtgtgtt atgatgtact tcttgtgagt tgtggtcagg
|
116041ctttgaaagc cactatgtat gtgtgtgtgt gtgtacataa aagtaagtat cagtcccagg
|
116101attcaaattc gaaccagtcc cagtcaaatt caatctaatt attttcacca cactaccaaa
|
116161agtctttctt cacattttct atataaagtt gaactaatta atacagcagt gaatgttaca
|
116221ttgtatcctt ttgcagtttc tcatctatga cattactatg cctgaattcc ccactggact
|
116281ttgaactcag tcttactcat ctttggatcc ccagcgtgta atacaggccc ttcataaaga
|
116341gtgaccatta ttactaacaa aatttcctct cactgtgaaa cctgctccca attataaaat
|
116401gaattgtgct ctttcgaact ccgttgatct attgtatgca gggtggatca tagagtctta
|
116461tttcataata acctagtgat ggaaaaataa caatgattca ggagtaggta atggaccttg
|
116521tcatctttta cactgaatga tgagatttcc ctaatttata gattttgtca tgcatgagat
|
116581gccctcagga gcttgcagaa atgccttggc acgttgctct gctgacatgt gtcagatggc
|
116641tggtgtggag gtagagggag tctcctctgc caagcaagtc taatggaata taacactggt
|
116701gccattgagg atgcaatgag aaggacccac agcagatcca gagactgcat tcataaaagc
|
116761tgcacagtat accatgtttt attaaggtat agacagatta gttgtgttct agcatagtgg
|
116821ttttcaaagc ctgaccacaa ctcacaagaa gtacataaca cacacacaca cacacataca
|
116881cacacacatt ttttcattta catcgtaact gatgagatat cttttatttt tatttgctta
|
116941attttttatt tctttttttt ttgagacgaa aggtgaattg tagccaaagt acttttagga
|
117001aattttaaaa ttacacattt tgaaagctct aggaggaaga gagcatattc aagtaaaacc
|
117061tttcttttat tcaaatagta gactaaaaaa ttgaccatag actaactcag caattgctgc
|
117121catatttctt agtgagggat tccttatgag ctccattgaa tgataaaagg atactcttcc
|
117181aaatcagagc aacaatcgtt tcttgtgaca ctgcatcctt tttcccttcc ttcaccctga
|
117241attgccccta gggtatacct aggagaggga gggctggcaa ccagctgctg ttgtgaaagg
|
117301gatgtcattc atggcctgcc ctattgggag gccaatcagg cggaacagcc cctctcccct
|
117361tatggtcatt ttatcctgaa gaaaaagggt ggcaaaaaga tggcaaaaaa gattgctgat
|
117421cacagatcac tgttacaaat acaacaattg gctgggcatg gtggctcacg cctgtaatcc
|
117481cagcacttcg ggaggccgag gcgagtggat cacgaggtca agagttcaag accagcctga
|
117541ccaacatggt gaaaacccgt ctctactaaa aatacaaaaa ttagccgggc atagtggcgc
|
117601atgtctgtag tcccagctac tcaggaggct gaggcaggaa agtcacttga acccggaggt
|
117661ggaggttgag tgaaccaaga ttgtgccact gccctccagc ctgggcgaca gagcaagatt
|
117721ccgtctccaa aaaaaaaaaa ggagggggtg gcaatgagac agggaactgc tctgggtcca
|
117781actcccctca catagcccca acccccatat ccaccccaca aacctccacc tccccacttc
|
117841cagcctctcc agtttcaaag tgacgcttac caacacgcag gctctccagg agcaccttga
|
117901aaggtaactt cttacatctt tccaaaacac ttataatcta attgttcttt ctcccctata
|
117961ttttgaagaa atgcatgctc tcaaaattga aaaaaacgcc tagaggaatt ttgtaaaaaa
|
118021attatatttt tccagtttct ccaaaggaca tataaaccct ttttaaactt agattttgaa
|
118081aagtcccaat agctgatttt caatcgatta ttgaaattgt tttttttttc ttccctaaag
|
118141gggagatacc aacctttgaa caaaattaaa ttaacttttc cccaaagtta aatgatttta
|
118201ctttgtgatt ttaggaatgt gtagaaagtg atttcagttc caactctttt aaagcaaggg
|
118261tatctgggcc aggcgtggtg gctccctcct gtaatcctag cgctttggga ggccaaggtg
|
118321gggcagatca cctgtggtca ggagttcgag atcagcctgg ccaacataga gaaaccccat
|
118381ctctactaaa aacacaaaat tagctgggta tagtggtgcg cgcctgtact cccagctact
|
118441cgggaggctg aggcaggaga atcgcttgaa cccgggagac ggaggttgca atgagctgag
|
118501atcacgccac tgcactccag cctgggcaac agagtgagtc tctgtcaaaa aaaaaaaaaa
|
118561aaacaaacaa gcaaacaaac aaacaaaaac aagggtatct ggtaatttaa ggtgaaagta
|
118621ttattcacta ttataatcaa ttttcttaaa aacaggagct attaggccca attctgagga
|
118681gagaaaaaaa agcagatttc aagggcccgt gccaccttct ttgtttaaag catagagaat
|
118741gataataaaa tgttaaaggt tcagcatttt ctggcattgt aaatttaatt aattaattat
|
118801gtaaattaat tatggaaatg agaaataaag tgaaaaggta tgtcaagtaa gaatcaataa
|
118861ttatcaaaac gttctctacc aaatgggatg caggggagaa gggtgagaag aagggaagga
|
118921aataaaggca aaggcatttg cccacagcct cagtccaggg tgttctacat gacgcagccc
|
118981cagagtaaaa aatactagcc acaggaatga gtggctctgt cttcctctcc agaactgacg
|
119041ggcaaaagag ggggaacctc accttttttt tttttttttt tttggaaact cactgggttt
|
119101tgatatggag aacaggaaga gaatctaccc tagcagcaca ttcacagatg gtttgtctgc
|
119161cctatttgct ccatctccct ggctcttcct agcacttctt ttcctacttt ccattttcat
|
119221tggccgcaaa agccacttaa atattccttt ggaaaactgg gcagtctgtc ccctttttaa
|
119281aaccacaact atttccagga gagttaaagg gctttcggac tgcccatcat tcatgcattg
|
119341tggtgaacta gctcagactg cctctacctt tagtccagat cagctgcctt gggagggcga
|
119401ttcctggagg aaaggatgag gagaggaagg ttttaggaca tcgtatggac tgaagccccg
|
119461ttggagggga agggcaggct tgaggaacaa gcctcagtgt tcctgaggct ttgtggaaat
|
119521gagaaatgaa tagagaaaga taagagactg gatcctaaat gcaattttgc ctatttcaaa
|
119581attttcacag ggtctttttt tttttttttt tttgagacaa ggtcttgctc tgtcacccag
|
119641gctgaagggc agtggtgtga tcatagcttc ctgaagcttg cagcctcgaa ctcctgagct
|
119701caagcgatca tcctgcttca gcctcccaaa gcgctgggat tacaggcatg agccaccacc
|
119761cccagcctca gggtcttttt aatccctaag atcttaaatt tcccagctac tattgttagt
|
119821aatgagttca atttacttac tggttaaatt ggcttttatt attattatta tttattttat
|
119881tttattttat tttatttgag acagagtctt gtgctgtcgc ccaggctgtg gtacagtggt
|
119941gcaatctcag ctcactgcaa gctctgcctc cctggttcat gccattctcc tgcctcagcc
|
120001tcccgagtag ctgggactac aggcacccgc caccacgccc agctaatttt ttgtattttt
|
120061agtagagacg gggtttcacc atgttagcca ggatggtctc gatctcctga cctcatcgtc
|
120121tggactaata ctctaaacgc tattggcaat agtttgttta caggaaaaac atcttcttat
|
120181aaagctgact gcaaatgttt taataaattt gcaaatatgt aattctgttt aaaatatcag
|
120241gaagtgagaa acatgttatg tgataactct ttcccattcc cgaaccaaga aaatgtaaag
|
120301gcagtaagtg tgccaaggac actgaaagga agctgcccgt acatctttga atcttctcag
|
120361gctgtttggt ttcatctgat tttaagctcc atggataaat ttcattgtaa caatttttat
|
120421gtctgtaaat cttaacccat aaataaaatc acaaatcaga aaagtacttt attaggccag
|
120481tctttgtcca agcaaatttg gtcccaaagc tagtttacaa ataattgcca cacagctaca
|
120541aggccagtgg gttgactatc gtagcatcaa tggtgtgggc agggctgcag cctctggggc
|
120601agcattagcc ccaactgaca gagggtatag gtgctcttaa caatctatga gaccccccac
|
120661aacctggact cagctgtcat aagcctttac ttcttatgtt cttcctaagt actttatcgg
|
120721gccaacaaat tcatcccatg aggaatccaa gatggaaacg tcaaaactat ctttggtatc
|
120781atgcttcctc cccctacctt ctctgccttg atcccctcct tcattctaca cattttctct
|
120841gatagtcgtg ttctagccac tagggagaac gtttcagtca atgggtatga tttctgctca
|
120901cctctttttg ccatagctat tagtaagctc tcaccactga tgtctcagct gactgtgaca
|
120961actgccagcg gctggtcagc ctgcctgcct tcatctaacc tgctctttac tgtctaccag
|
121021agtcagcttc gtaatacaca ggtgccctcc tcctcctgtc aacattcctc aaccaaagcc
|
121081tcagtaaact gtctctcatc taccttccca gcattcttga gccattccca ggatagccta
|
121141ggccctttag acctctgaga tgttataccc ttcctcattc tggaatgccc ttcagtgtct
|
121201tacccacctt tcagagttct atttattctt tttttttttt tagatggagt ctcactctgt
|
121261cacccaggct ggagagcagt ggcaccatct tggctcactg caccctctgc ctcccaggtt
|
121321caagtgattc tcctgcctca gcctcctgag tagctgggat tacaggtgcc cgccaccatg
|
121381cccagctaat ttttgtattt ttagtagaga cgaggtttca ccatgttggt cagtctggtc
|
121441ttgaactcct gaactcaggt gatccaccca cctcagcctc ccaaagtgct gggattacag
|
121501gtgtgagcca ccacgaccag ccttatttat tctttagagt tgaattcaaa tgccacctcc
|
121561tttgaaagcc atccttgatg tccttgtgag gaattacttt ctctaccaca ttatatattc
|
121621cttttactgt agaaacgtca ttctgcttta tattataaat tattagaaat atgttgtttc
|
121681ccccatgaaa gtttcaagtt tcctgagttt aggcctgatg atacaatcat tttcatatga
|
121741ctcacagcaa ttgccttagt atatattaaa ttgagctgaa taagccatgt acccagttga
|
121801acacaccaaa tattttagtg atgtcatttc tttattggtg aaagagcaag gccaacgttg
|
121861atcttaatgt tattctctct tttatcttat tcagctccct caacaaaaat acattctcat
|
121921agattaatgt aatcaccacc tcactcctct caactttaga ccctatacta gcctgagaaa
|
121981tccagatcca acttaatgag ttctccttta tcccaagtcc tcatgaccta taaatgtaac
|
122041ctctaggaca atgttacaaa gagtgagatc tttataccac ctgcattctt gtcaccaaac
|
122101gtgtaagtta aaaattcaga ttctgagtgt ggtgactcac gcctgtaatc ccagcacttt
|
122161gggaggctga gccaggtggg tcacctgagg tcaggagttc gagaccagcc tgggcaacat
|
122221ggtgaaaccc tgtctctact agaaatacaa aaattagcca ggcatggtga caggcacctg
|
122281taatcccagc tactctagag gctaaggcag gagaatcact tgaacctggg aggcggaagt
|
122341tgcagtgagc tgagatcact ccatggcact ccagcttggg caacaaagtg agactctgtc
|
122401tccaaaaaaa aaaaaaaatt tagattccag gacccgaccc tacacctccc taattagaat
|
122461ctcagagagt ggggccctgg gaatctgcat aattcataac cttctcagag ctctggtaca
|
122521caagaaacca tgagaatctt tgttctggaa acttcagaga acttggctga gggccacccc
|
122581aggatttggt ggcgtccctg aatctcccat tagctctgac actgactaga cttcaaatat
|
122641cacagaaggc aagcattgaa gtgtgtttat attcaaatag ttttcttgtt gagaatcaga
|
122701aatattaata aaacttttgg gagtcaaagt aatgagaaga caaggaactg aacttgcccc
|
122761ctgatctgtt atcatttggc agtaaggtac atattcaaca ataggataat tctgtataag
|
122821acctgaatct gaccttcttt catctttcac actgacaatt ctgtctctaa acacaggatt
|
122881aaatgaggaa ctaaaattca ccaagatcct gctaggtgtc aggtacagtg ctagctgctt
|
122941ccacacattt ctcatttaat cagccacctg tgaaattgct atgatttatc accatttggc
|
123001agaaaaggac atttagggca caagagatta aataagctgc tggttgggta cattaagtat
|
123061taataaataa tcagatagat aagttaggta gttaagtaag ctgccagatt agtaaacagc
|
123121tagtttcaaa tcccagctcc aacatttact agttgtatga cccttgggga aactcaacct
|
123181ctgagtctca tggcactgct gataaaacgg aaaacatcat cctcacaagg ttctgaggac
|
123241tagggatgga ctcaggtaca cacagcaccc agtacaatgt ctggccttca gccagtgata
|
123301gcaacccttc actcacctct ccattccctt ccagcccctg cattcaaaaa cttttattta
|
123361tttatttttt taaittagga ggctctttgc tcagaatcct gaaaaggctt ttgttacttt
|
123421attttttctt ttttttcatc ttctgggagc acagaatagg cttctgctcc tttaaataac
|
123481tttaacaggc accaaaggaa cactgctagc tctttcttaa ttctgtaggt ccacatttag
|
123541gaaaaagaaa ttgtcagcct ctgacttatt tccagcttac aaaaaggctg tgatgttggc
|
123601agcccgggga aagcagttcc cgtgagtcat gctttcacct ttcagccagt gaagaacagg
|
123661aaatagtcac atcactattg ccaacaagca cagcgaatcg cttccaccac cgggctttcc
|
123721cagatgacgt cagtgagcca agtgcagggc atcacccttg ccagatggcc ccggaagagt
|
123781ctcagctgcc ctgtcaagtt tagcttctca agctccccag aaccagcatg gcaaggatca
|
123841cccctccaga aaaggaaatg atttctctga tcatgatcaa accatgtcat aattttagct
|
123901gtaggtggtg agtatcagtg actgtattat agatggtttt ggttcacagc tatttttttt
|
123961ctcggtatat ttactctcaa gggcaaaggg gtggcattta tcacaatgct atgattcact
|
124021ctactagact ggctgggttt catttcatct ttgagttcta gacctaaggc caaaaggatg
|
124081tcagaatcgc cacccagagc tagatgcatg ctcaatgcaa cctggccatc tctctcggac
|
124141agtggccact aaacacaagc tgcaatgatt attgttgatg ttagtcaatt gatttgtccc
|
124201ccttttaata atccatgatc cacacagaca tgaatctaaa cctttttttt gaacctatct
|
124261ttttcttact agttttctta catattttgg aataacaatt tccctggtta taatacacaa
|
124321tgtgtgaaac actaattgca tttattggtc ctaaattcat tcccaagtct aggatttggg
|
124381gatttagtgc acaaatccac tttcttcctg ctcatgttgt tcatgacttt atggattctg
|
124441cttacatttc ctcccaaagc cttggtcttt ctaagcagaa atctgaccag cctctgttcc
|
124501tactctgctt cctccaccac cttgactgtt aacatacact gttgtgggag aagcttttca
|
124561ttaaatacgc aaacaaatca acaataagga agaaaacaac tgaagcacag aaggatgatt
|
124621gtaacatgga cttgtgcttg tttaacagta cccatactgt ttggtgagtt gcctaaatac
|
124681agagggagat ggcaacttaa caggatgggt ttggagtctg aattaaataa acaacatggc
|
124741aaaagaagga agaaaccaaa agttgggtga ctagggcttc ttggattcta ctcaacactt
|
124801tccacaccta caggcctctg attctatccc caccgctgct cctacactgt ctatgtttct
|
124861cttttacaac aacaacaaaa aaatagcact tgtttactgt tcacaattat tgaaataaat
|
124921cactctaatt tggattcctt tatatgagaa cttccatatg cttaaaactc ccgtagcatt
|
124981tttatagtgt acaggtcata aacatgttgt ctgaagatgg gcaaagtagg tcgtagagat
|
125041aggaagtgag ttcacatcac ggcgtgagtc aaggcagcag catatgagct caggggccaa
|
125101atctgagctg tgatcatgtg acacagtcct caccttcaga gatgacattc tcccagaagt
|
125161ccagggtgca gaaatggata ggctgatgtt cacttttgaa gaggaccaca atgaaaccct
|
125221tttaatatta ctcaatgatt ccacagacct cctgggtgtt aaatcaggtg aatctatttt
|
125281taaaaattgc tatttacttt tttaggtggc tgatcaggac agtatgaaat ttcatacagt
|
125341ttcctaactt gagaaaacat ggtgatgcaa ttcctccaac caggagggat ttatggacag
|
125401cggtggctac gtcctaatct gcccagaata caggatgact aaacaaattg gcaaacggac
|
125461gcagctttct ctctctctaa gaaaagtctg ctgagaaccc tcgttcccac tctgtttctg
|
125521cctccaagaa gaaaagccta aaactcactt tcttccggac tctttcaagg tcagtggagt
|
125581tcctctgggg ttcatattca gatactttgg ggattgatga tggatcataa atgttgctga
|
125641agttcatttg agcccatggc ctctggtttc agaaccattc agccagtcaa atatttaaat
|
125701tttagtgagg caggggaaag ggaacccctt cgggggctgc tatacagcaa cttatattca
|
125761caattcacaa ttaaatacac ttcagtttct aaatatatgt tactttaaaa ttatacagtg
|
125821cttagcaatt ttcaaatttt cattttgtgc tcaaaatatt ttcaggaggt agctgttgtt
|
125881atacccattt gtacaagcaa gaaactgagg tttcaagagg ttatgttgct taaacccaga
|
125941tctgcctgat tccaaacctt atgctttttt taaacttcta ttttgaaata attatattaa
|
126001gtcacatgag gttgcaaaga aatggaaagt ctcatgtccc ctttctccaa acctcatcca
|
126061atgttaacat ctaagaaatt gacactggca caatccacag agcctattca gggttcacca
|
126121gttattcacg cacttgtgtg tgtgcatgtg tgtgtgcagc tctgtgcaat tttgtcatgc
|
126181tctttttttt tttttttttt gagacatagt ttcgctctgt tgcccaggct ggagtacagt
|
126241ggcacagtct ctgctcactg taacctccaa cttccagttt caagcaattt tcctgcctca
|
126301gcctcctgag tagctgggat tacaggcatc tgccaccacg cccatctaat ttttgtattt
|
126361ttagtagaga caaggtttca ccatgctagc cagactggtc tcaaactcct gacctcgtga
|
126421tcttcccacc tcggcctccc aaagtgctgg gattacaggc gtgaaccacc gcgcccggcc
|
126481tgtcatgctc tttttataca tgaaccatac actgttctgc caattttaaa tatgaaggca
|
126541gattacagaa ataaataaaa tgatttttct tttactacaa cagtatctac caataatcac
|
126601atacatgacc aaatagcttt cacttctagc tgccgttaag aagaaagaaa aggatgaaaa
|
126661gaaaaaaaat cctataaacc ccagttcttg aaagcattag tctgtgctat gtgccttagg
|
126721tacagattaa ggaaacacaa tttgttgatt tattgataat tgtgacagca atcttccctc
|
126781ttgtcaggaa gttctataag taaaataaag gtaattttac cttgacttca Ratttagtct
|
126841catcatcttc ctttccccgg gagttcaact ctgtctccgt ataaggttcc tcagacgttc
|
126901tcagaggacg agctagaggg actaagagaa cctgccatta gtgtggttat ttaacttata
|
126961aactataact cagtgcactt tgtctgattt ggacaaatag ctggaccacg tcaatgtggc
|
127021taactataaa agctcacttg agctgctgcg ttgatttcct agggctggat gaaattggag
|
127081gtgaaggaga gacacagagg agaaatagaa tccttgactc cagggacttg acatttcagc
|
127141agaagagaaa aaagtcacac ccagcaccat atgaaacatt aaactacaac aaatctgtac
|
127201atatagcaat gtggtaaaga atagtagatt ttctgtcatt cccattttta aggcccagct
|
127261aaaaggtcac ttttggctgg gtttggtggc tcacacctgt aatcccagca ctttgggagg
|
127321ctgaggcggg cagatcacct gaggtcagga gttcgagacc agcccggcca acatggtgaa
|
127381atcccgtctc tattaaaaat acaaaaatta tccgggaaca gtggcaagtg cctgtaatcc
|
127441tagttactcg ggaggctgag gcaggagaat cacttgaacc tgggaggcgg aggttgcggt
|
127501gagctgagat tgcgccactg cactccagcc tgggcaacag agctagactc catctcaaac
|
127561aaacaaacag acaaacaaac aaaaaggcca ctttcctcat gaagtcttcc atattacaaa
|
127621ctttatggat tcttttatgc actgctgctt tggcatgcat catgtgtaca gcataatgtt
|
127681gcacttgatg ttgttcttgg attcaaagac taaattctag gtactacatt gtattgaata
|
127741tattttccat tataaaggta attaattttt gcttattaca gaaaatctga aaaacactaa
|
127801actcttaacg ctgaagcaca atcacttagt atatttcctt acagtcttct ttcaaatgct
|
127861ctccctcttt ttacacacat acatgtacac acacaatcat actatgattg tattgtaaga
|
127921ggatggccat gcctgctgct cttgctcttt tctcttggcc actctatctc ccttctcccc
|
127981acctgggaaa tatcctttct tcaagctcca tggccatttg gtagtaaaat tgggacttga
|
128041gaggagaagg cctcaaggct tcctaaccca ccttaccagc tttgccaagc attgtgggtg
|
128101atggccacaa ggctaataga taagaggtac tttgaattct tatttgtcac agtcaccacc
|
128161cttgcatatg ctggtccctt gggaaactca caggagacat gattaatccc aggcaggatt
|
128221tgagcatttc tttctttctt tctttttttt tttgagacag agtctcgctc tgtcgccagg
|
128281ctggagtgca gtggtgtgat ctcagctcac tgcaacctcc gcctcccagg ttcaagcgat
|
128341tcttctgcct cagcctccca agtagctggg actacaggcg cgcaccacca tacgcagcta
|
128401atttttgtat ttttagtagc gacggagttt taccacgttg gacaggatgg tcttactctc
|
128461ttgacctcat gatctgcctg cctcggcctc ccaaagtgct gggattacag gcgtgagcca
|
128521ctgtgcccag ccaattttag catttgtagg tcccaagacc aaaatgccat tcattgaatg
|
128581ccaccaatat atcaccctga ttcttagcta tggtagactt gatggaggtt gaccatctga
|
128641tctccagagg ccccttccaa cccttccatt ctgtgagcca actggaagca gcttgggctt
|
128701tctatgggtt tttcatagat gttatgttga aaatcgcaga aaattacact gctaccccag
|
128761gttatacata ttaccattaa tgctgctttg taataacaga caatcctttg ggctcctccc
|
128821tctctgtggg atctctataa agtgagtgat tccaggcaca ataactagat gctagaaatg
|
128881catgcactat aatttgtgac accatgactg agaagcgcct gtccttgaca ctgtaagtag
|
128941agtgaagcag tgaaaggcgg ggccacagaa gccacactgc cagtgttcaa accttgctct
|
129001tccatgcacg agacaaacat gattacagtc acctctgtac cttacctttt tcatctgtaa
|
129061agtagggaaa aatgagaaat cctacagtaa agggctgtga taaggcttta atgagttcat
|
129121ttgtgaagaa tgtagatcat atacaatgca taacacattt tagctattat tgccacatgg
|
129181cactaaaaag ttttttcacg ttccttatga acttcagagg tgttagaagt tgtagccaag
|
129241gcatccagct aacaagagtc agagctgaaa ttccagctct taagcccctc cacacatctt
|
129301ctttatactg tgaaatacaa ttgcttatct tggcacagac tcagttacta aggaatcaga
|
129361caaaaatgtt tgaaaatcct tttagtgact tgctggagtc cacactcagt agatacttac
|
129421caaaaacaaa agtgcaggat tgttctgcaa aacgagctag ttgtttgact taggtcaatg
|
129481acaacctgtt cagacttgac aaagacctat ttattctggg aaggagtgtt atctattatg
|
129541aaatcttgta tttgaaaagc tgagaaacaa ccctgtaatt cctgctttat ttacttgaaa
|
129601caaacatatg tacctggaaa caacgaatga ggccaagtca tagatgtgaa catagtttag
|
129661cttgaggaca gacgaaaggt caagagaacc aagttctgtt tccaatcatc taagaaggat
|
129721gtctctgtgt atgtttgggt atgtctgtgg tatgtgtgtg caagtgtgtg agagtgtatg
|
129781tgtgtggatg tgtgtgtgtg tgtttgcaga taaaaattca ggaaagaaat acactaaatg
|
129841ttatcaaggc ttacttctaa aaagtaggat acatggtgga agacaaggga tcgtaaattg
|
129901tactaaatgg agaattacca aaacacccca caattttcat ataaacaaaa actgaaagaa
|
129961tttattgcta acaggccagg catggtggct cacaactgta attccagctc ttagggaggc
|
130021agaggcagga ggatagcttg agcccaggag ttcgaaacct gcctggacaa tatagcaaga
|
130081ccccgttctc cacaaaaagg aaaaaataaa gacaagaaaa gaatttgttg ctagtagact
|
130141ccccaacaat aaatactaac agaagctctt tattccgaag agaaatgaca caagatagta
|
130201attcaaatct ataataagga atgaagaacc ccagaaatgg tgaataaggg ggtatgtaca
|
130261cacacacaca cacacacaca cacacacaca tgcacacaca cacgtatgta tttctcttaa
|
130321tttgatacat gactatttaa agcaaaaatt ataataccat agtgggggat taacatatat
|
130381agatgtgata tttatgataa gaatagcaca gaggatggat ggggagcata tggaagtatg
|
130441acattgtagt atgtagtatg atttcctata ttttgcatag aatggtatga aactaattca
|
130501atagatcatg acaagttaag gatgcatatg gtaatcccca gtctggtgaa aaacagtaca
|
130561aagagatatg ataacaagcc aatagaggaa ttaaaacaaa atattaaaaa atatttacta
|
130621acccaaagga aggcaggaaa ggaggaaaag aggaataaaa agcacatgag acatgtagga
|
130681taacaaaaca ggaactctaa atccaactat atcaataatg atgatggatg taaacataaa
|
130741aatctaatca ctccaattac aaggcagagg tcacagtgta taaaaaggca agacccaact
|
130801atatgctgcc tacaacaaat atactttaaa tacaaagaca gaagaataga aaacaaaaaa
|
130861aatatgttct gcaaacacta agcatgagaa aactggaatg gctgtgacaa tatcgcacaa
|
130921gatagacttt aagagtattt ctagaggtaa ggagggaagg agagacattt cataattata
|
130981aaagagctaa tatatctgaa agacataaaa accatgaata tgtatgtgct taatgacaga
|
131041ggtccacaat acacgacaca aacaaatgac atgtacatcc tgcccaaggg cagtttattc
|
131101caaggatgta cagttgtttt aacatttgaa aacaaatcat tgtaatttac catattaaca
|
131161aataaagaag aaaaaccata tcattctctc aatacatgga ccaaataagc atttgaaaac
|
131221tcaataatca ttcacgataa aaactctcct aaaaaataga aatagaagag aattccctca
|
131281atctgataaa agacatctgt ggaaaaccta tagcttacat catacttaaa gatgaaactt
|
131341gaactctttt cctaatattg ggaaaacaca cagatgtctg ctctcaccat ttctatttga
|
131401cattgtagtg gaggtcccag tcattataat atgacaagaa aaaaagtata aagattgaaa
|
131461cagaaaaaag taaaagcatc cctattcaca gatgatagga ttatatttct atatagaaat
|
131521ctattcctat tcttaattat atatggtaaa ttccattcat tatagggtta aaaaaatgtt
|
131581aaatgcctaa ggcctttaca ctcaaaacga ctgcattgtt gagagaaatt aaagatgacc
|
131641taaaaaacat aagttataac atattcagga attggaaaag tcaatattgg taagataata
|
131701gttctctcca aattagctca tatatccagt gtaatcccta tcataatccc agcagaaatt
|
131761gaaaggtgat tctaaaattt atggaacaat gaaaaggacc taaaatagcc aaaacaacct
|
131821tgaaaaagaa caacgttgga acatcgcatg acttgatctt aaaggctgac taataagcta
|
131881tggtaatcag gaccatgtgg gattggcata agaacttacc tattttttaa atctttgctc
|
131941aaagaaccaa ttttactact ccattgctaa taaaacatgg gccttttaaa ggtcctgaat
|
132001ggggtctatt ttatgctgtt attattatgt tattattatg atgcatttgt tgttgttgtt
|
132061gttgttgttg agacagagtt ttgctcttgt cgcccaggct ggagggcaat ggcgcaatct
|
132121ctgctcactg caacctctgc ctcccgggtt caagcaattc tcctgcctca gcctcctgag
|
132181tagctgggat tacaggcgcc cgccaccatg cccaggctaa tttatttata tatatatatg
|
132241tatatatatg tatgtgtgtg tgtgtgtgtg tatatatatg tgtatataca tatatgtgta
|
132301tgtgtgtgtg tgtgtgtata tatatatata tatatttttt tttttttgag acggagtctc
|
132361gctctgtcac ccaggatgga gtgcagtggc gccatctccg ctaactgcaa gctctgcctc
|
132421ccaggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggtgcccac
|
132481caccacgcct ggctaatttt ttgtattttt agtatagatg gggtttcacc gtgttagcca
|
132541ggatggtctc gatctcctga cctcgtgatc tgcccgcctc aggctcccaa agtgctggga
|
132601ttacaggcgt gagccaccgc gcccagccta atttttctat ttttagtaga gatgggtttc
|
132661aacatgttgg ccaggctggt ctcgaattcc tgacctcaga taatccaccc gccacggcct
|
132721cccaaagtgc tgggattaca ggcgtgagct accgcacccg gcctttatga tgcattttta
|
132781ttattccttc agtagattgt gtgtttctcc ttgcatccag gcacttggtg ttatctaagt
|
132841gtttatgtct tccatgtctg cactatgcta tatctgtagt ttgttttaaa tagtatctgt
|
132901taaaacagcg accattatcc attgtagaca accagtcaca gtcctcatgg tgctgatgaa
|
132961acacaaaagc cacaaagctt cttttcctca aataacctac ccgaggtgga gggctggctg
|
133021gtttttgatg acacccattt tggtgaagac tcaggatgtg gggccacagg ttgcactgga
|
133081cgagtctgtt tggctgccag tttcatcaga ctcacttgcc tcttgtgaaa tatttcctgg
|
133141acatcatcca gcctctgcaa aactttctgg gctttggcct acagtaacaa aagcaaatca
|
133201tgatgaacag gtctctctgt atacagcctg aggacacgaa gcattccctt tctcccacct
|
133261tcccctactc cccccatccc tacctccctc aggtgacccc ctctgggcat cactatgcaa
|
133321gtcgctgcag gtcctgccat gctccagaat tgggtatcta aggattagcc tctcctactt
|
133381gagacccttg aggacaatga ctacatcctt tcactatggc gtctccagtg cctggaacac
|
133441cctggcacag gagtttgaga ccagcctggt caacatggtg aaatcacatc tctactaaaa
|
133501atacaaaaat tagccgggtg tggtggctgg cacctgtcat cccagctact tgagaagctg
|
133561aggcaggaga atcgcttgaa cccaggaggc agaggttgca ctgagccgag atcatgccac
|
133621tgcactccag cctgggcgac agagcgactc catctcagaa ataaacaaac aaacaaacaa
|
133681ttagaataca atgtggcttg tgtcatgtta gacagagcaa agaattttgg cctgagtcca
|
133741tggatggact tcagggcatt ccccagaatt acacaaacag ttagacaggc tggatataat
|
133801ctgtttgttc ctccactgca tcttctcttc ctttctttgt gcccaggaag ctgattaaaa
|
133861gaagctccta aaccagaggt gcagacaagg tgatgatgtg gctctcagag gaaggtgtgc
|
133921tacctacaac cctgctggct tcatggaaga atatgcttct caaatgcaaa tccaatcaag
|
133981ttatctccct gcttaaatcc aaactcgctc atgtggccca caaagcctac cttgcctgcc
|
134041tctctctaac ctcacccaaa acacacttcc attgctctct aggttccagc accctgacct
|
134101tttggtctgc actgtgccag gctccctcca gccctgaagc ctttgcacat gctgttcctc
|
134161ctgtctggaa aggctctccc atcttgtcta ttcgttctcc aggctcaagt gactcttcct
|
134221gagagccttc tctgacccca gtccaggtca agttcctctg tcacatgcct gaccctgcat
|
134281ccctccttga cagcacttat atcagcttgt aacacatttt tgtgtgatta ttttgttaat
|
134341gtcagcctct cccacaaact gtaagctcag tgagggatgg aagcatgcct atttttaatc
|
134401atcatggtat cctcagcact cagcacagca catggtacat caggaatgct cataagcatt
|
134461aatagagaaa tgactgattt gagtcagacg aagactcagt atgccaggac gttcaggccg
|
134521agagtctaag aggccgccgg agggcttcgg aaccagtgag cccactcaat tcagcctgct
|
134581cagtaccctg tgtgtacttt atcaggaaga aggtacagtc cctccctccc ctatccgttt
|
134641cccaaccaca ggatcaaaat aacccggaag cattaccttt gcatcgaggg tgagcagcaa
|
134701ctcaaactcg ttgtaaaact ccttggggct gagcaacggg tactccttga ctgtgcccag
|
134761gaatgtcgca atgtcgttca aggcgatatc aaccccttct cgagactggc acttgtctac
|
134821agcttgggaa gccaagaggt agattcctgc ctcacaccat tggctgacct tttggaaaga
|
134881aacagtgccc tgtgcacttc gcctgaccac aactcagagc caccgtaatc ctcagcaggt
|
134941ctgagcttgt aaggtgtcta caaggattcc cagacaatgg gaaattgtca tgggacggca
|
135001tcgagtttaa ggggtctaac cactgtaaat tacactatga gggggacaaa cccaaaccag
|
135061ctgatacctg tccacttctc agggaagtca ctcggtcagc aaaatgagtc tcttccatta
|
135121acagtaattg ctacatctcc aggaggagac agctaaatat atatttaatt aaagacaggg
|
135181tttcactctg tcacccaggc tggagtacag tagtgcaatt atggcttaat gcagcctgga
|
135241gaggtctacc ccaggctcag gtgattcttc caccttagcc tcctgagtag ctgggactac
|
135301agatgcatgc caccacacca ggctaatttt tccttccttc ctcccttcct tccttccttc
|
135361cttccttcct ctttctttct ctctgtctct ctttctttct ttcctttttt tgagacaggt
|
135421tttggccatg ttgccgaggc tgctctcgaa ctcctgggct caagcaatcc tcccacctcg
|
135481gcctcccaaa gtgctgggat tacaggtgtg aggcactgca cccacccagc cttatagcta
|
135541aatatctctt aggctggtct aaccatagag aaatgtaatc aatggctttt ggggtttacc
|
135601tgctagtcca ctcttcttgc atccgaattg gttaccagaa cacagggtga ttaataagac
|
135661attagacctg gcccttacat ttcctgggag aagggcatgt cccttttaac aaaaacacaa
|
135721ctttcatctt tggattccca ggtgatccct atttgcattt actggcgttt gtctttcgta
|
135781aggaagcaag aatgcaaagc tttgtaactc agcacagcga tactcaagag tttctggatg
|
135841ctgggaggac attagatagg tgatgagttc taattattca atttttaaaa aagactcatt
|
135901ttctttgctc ttttgaactc cactgagaca cttgaacaga aagacaggga gcccttatgc
|
135961tacctgaaga gttatatgaa aagaagtttc cagtgccaat acctctgcat ttccatttac
|
136021catgtgacct gaaaagcaat ataaagtaac tatacagaga aaaaagatca aaatgcaaca
|
136081cgccaaagtg gttgtctttc taagtgggaa aatgataggc aacttaagtt tttgtcttat
|
136141ttttttccta gattatttac agtgaatatg taccacattt agaataataa aaaatcataa
|
136201agatatttca gaattaataa ttaccattat gtagggatgg gggatagtgg gatatgtacg
|
136261tgcccatgag taaccttttt cttcctacat ttttggattt ccacaataat atgaactcat
|
136321gctttgatat atgctgtgaa aactttctct ttacacatca tgcccagatc tgcaaaaaac
|
136381attaggctgg gattttctgt agagttacta tggctacttg ctttctctct ctctctgtct
|
136441ccctctctct ctctcaaaca cacatgcaca cacacacaca cacacacaca cacaccaggc
|
136501ttataatctc tggagcaaaa atggagttgg gaaaacagca gctgatccca cagcgagctc
|
136561agcacacaga gcaggctgca caccagcccc ttcggagcta cttgcttctg aaacaactat
|
136621atttcattga cattaaaatc cctttagcaa tgggatgagg taagcgcctg ggtgggtgcc
|
136681ccctgccatg caagaggaac agctgtgggg atggagcatg ctgactcatt gccgtcagcc
|
136741acatgctgcc tgggaccagc tcacagggaa gactccagaa accgctgctc ctgctgactg
|
136801ggaacatacc ctagaggtca cctccaaagg gcacccctct ccttgtgggc ccctggcatg
|
136861cgcccttgct gtctatcctg tgaagccttg gtgtggaatc tggcaggcct gactttaatt
|
136921ctggcttccc ctgtgtgcac catgtgtggt cttgggcagt catttacccc agggtttctt
|
136981ggtgacatcc ctgcaccacc tgcaccagaa tcatttagac actttactaa aatactagtt
|
137041cctgggcagt attccagacc tatcgacgct gagtcttcag ggcagtgcat aagggaatct
|
137101gccatataac agctcactag gtgattctcg tgtgctacat tttgagaccc agcagagtat
|
137161cagtttctgc ctctgcacaa tgaggccatt aataccttcc tcagaggttg tcttgaggat
|
137221tataaataga tgacataatt atgttcctgg taggaatgca gtaggtgctc gatacatggt
|
137281agggggtata aaatggttgt tattacttaa gcttctccaa aaagagtcaa aaccctttgc
|
137341ctttatatga gggaagcact ctgcaaatat agtgcttggt tctctgtaca cctgaaaggg
|
137401aatcaagaag tgttcccaca gggccaagcc aaaacacact cttaaagtcc ggctccacac
|
137461agatagaaat gggcttcagt taactttaat gggatgtggt gggatggcca gagcactttt
|
137521taccttcgtg ccaggtatac ttctacaccc caggatctgc acagttttta atgcctctcg
|
137581aacatctttt cacataaagc actcaagcct ctcagcaatc acacaaggaa gggaggacga
|
137641gtatgatgga agcttcttca cagaaaatct tgcagacatc atgttcttgg ctgtgttttg
|
137701ctcaccttgt ccagctgtct atgaaactct aaggactttc ctaaaatgtc ccattttttc
|
137761ttgtttccat tgatgaaatc gtcacagagg tgcctgagct ccacacaccg gggcctgatg
|
137821gcatctgctg cataatggtg gctttggatg agctggtccc caaccagtgc cagcagcwgg
|
137881gccttttcca ggggctcctg caaagtgaac acccacagcc aggcgtcaga agtcagagca
|
137941tcatgaggct gagagctgcc tggtactgtg tgctccaagc ctggagggag gctgtggaga
|
138001tgctaaccca ggatgaaggc tggagaacct gagaaagctc ggaatggttc caggcccagg
|
138061aagttaagcc tggcccagag ttgtccacat gctgaacaac agcagtcatt cattcaaata
|
138121cctgttgagt tctgggctag acatcgagga tatagtgtta acaagcccaa aattttcaga
|
138181ttaatggaga attcagatat caactaaatt acacaaatcg ttaaattatt acaattgcaa
|
138241taaactctag ggcagaaaag catggagtgc acataataag agattttgaa tacccctatt
|
138301aactaaagga acaagaagag ggactgacac ctgtccttga ggagagtggg gggtgagctg
|
138361aagttgaaac actggtgaaa attggatttg gacaactcaa aggtggtcat gacacttaag
|
138421aaatatgctt gtctaggctg ggcgtggtgg ctcccacctg taatgccagc actttgggag
|
138481gccgaggtgg gcggatcacc tgaggtcagg agttcaagac gcgcctgacc aacgtggaaa
|
138541aaccccgtct ctactaaata caaaaattag atgggcgtgg tggtaggtgt ctgtaatccc
|
138601aactactcag gaggctgagg caggagaatc gcttgaaccc gggaggcgga gattgcagtg
|
138661aattgagatt gcgccactgc actccagcct gggtgacaga gcaagactcc atctcaaaaa
|
138721aaaaaaaaaa aaaaaaaaga aatatgcttg tctaaaccct ttcccaaagc ctgtaagggc
|
138781cctgtctaca ctgaccctgt ctgctcaatc acatttccta cctctttctg catgacactt
|
138841cgctctaacc acacgtgcca agttttcctg tttgtttaag cattccttca ttcatccttc
|
138901tcatattatt gagaacctgc tatttgccaa acactgtcat aggtgctggg agttcattgg
|
138961taaagaaagc aggcaaaaac ccccacctca tgaaatgaag cttacatttt aatgggagac
|
139021agaggcaata aacaagtgca tgtgtaggtc atatggtatc ttagacagtg atgagtatgt
|
139081ggagaaaaat tagatggtgg ggagggcagg gagtgctgga gctagtattt taaatcggat
|
139141ggtgagacag tctccctgag aaggagtact caagctatgc agaaaagact tcacatagaa
|
139201agcctgagac taggccgggc tgtggtggct cacgcctgta atcctagcac tttgggaggc
|
139261cgaggcaggc ggattgcctg agttcaggag ttggagacca gcctcggcaa cacagggaaa
|
139321ccccatctct actaaaacaa aaaaaattag ccaggcatgg cagcatgcgc cgatagtccc
|
139381agctactctg gaagctgagg caggagaatt gcttgaacct gggaagagga ggttgcagtg
|
139441agccaagatc gtgccactgc actccagcct gggtgagagc taggctctgt ctccaaaaaa
|
139501aaaaaaaaaa gagaaaagaa agcctgacac tacagcctta gaaagaaaga cccgatttta
|
139561agattggccc tttgttggca tctaggaact tagatttttg ggaaggtttc ctccattccc
|
139621tgatgtgaat ggttcatgat ccctgaactg tttgtgcaaa cagtatggtt tatggtgatt
|
139681acttgctttt tcttctggga gtctgaaatc ttggtacttg ccagacagaa gctgctgaca
|
139741tgaccagcca ccaataaaac ctctgggcat tgagtctcta atgagctccc ctggtagaca
|
139801acatttcaca catgttgtca caacccacag acgggggcag gaagtatgtc ctgtgagact
|
139861cccacaggag aggattctaa gaagcttgtg cctggtttcc tccagacttc acctcgcatg
|
139921cctttctcct ttgctaattt tgcttagtac tttctcatct taatagatca taactctaat
|
139981acagctacat gcagaatcct cctagtgaat cttcgaagaa atgtgtgcat ggtcttggga
|
140041gcgctctgca tacaagctga gacctgaagt cagggacaag ccgtgcagta cttggctggg
|
140101aggtgaaggc gtgtttgaca agtttgggta gcaggaagga ggccagtgtg gctgcagcag
|
140161agggagcaag aaggaaatga gtggaagact aactagagga aagagggggt tccatagccg
|
140221gggtgagagg aaagcccctg ggtttggagg gaggatctcg atcatgtttt tgaaaggacc
|
140281actcccggta cagtgtccag aataagagga aatgcaggga gactcattaa ggggctgctg
|
140341caggaatcca gccgagagat acggcttacg gctggtcacc aaactagctc ctgactcgac
|
140401ccttctctgg attgttcttc cctgggtcat gcagagctga gttcctgggt cacctcctca
|
140461cagcgcttcc ctggcgacta tatcttaagt cattetctac aacctattcg cccagtcacc
|
140521taggccctct cccacacttt aattctttaa cagcattatc tctatctaaa aactattttc
|
140581tttatttact ttaatgtaga attcctccct cctggctggg cgcggtggct cacaccagta
|
140641atcccagcac tttgggaggc cgagacgggc agatcatgag gtcaggagat cgagaccatc
|
140701ctggctaaca cggtgaaacc ccatctctac taaaaagaca aaaaattagc caggcatggt
|
140761ggcacacacc tgtagtccca gctactcggg aggctgaggc aggagaatag cttgaacctg
|
140821ggaggcggag gttgcagtaa gctgagattg tgccactgca ctccagcctg ggcaacagaa
|
140881tgagactctg tctccaaaaa aaaaaaagaa ttcctccctc ctccactcac tcccaccaaa
|
140941atgtaagttc catgagagca tttagtaggc atgcaataaa tatttgatca acaaaataaa
|
141001tgaatgagcc aatgagctac atgatgcggt gacctgcttg gctggaactc tgtgaagcaa
|
141061tcagcacaga tgactgccac attccaaaag gtctccagga gcagagagcc catgagcccc
|
141121cttgccagcc acactaagca tccagtgcat cactgcactg ctttagctgt ttacagtaac
|
141181acaaggagtc acggtaactc caggtgcgta catcttgccc ctctcttaac ttgcactggt
|
141241ttatggtttc aacaatttcc aaaccccttt cctcttaccc tcccagtcat tcacgaagcc
|
141301ccgcagggac cgtcgccttc ttaatgcctt tcaaattctg accccatctc tgccacctcc
|
141361ttgtcactgt ctgctcaggc ctcatggctt ctcatgggga caactggtct ccctgctttt
|
141421cttcaggctc tccttcaaat catgctccag actgctgaca aaggagcaat tccaacatat
|
141481cttattgtgt ctacatcact cccaagcttc aagccctttc ctgggcgccc agggtcttca
|
141541ggagcaagct taaactcttg agcaatgcac acggggaatt tcattatcta gctcatacct
|
141601gggtgtgcct gacttaccaa gtcctcttcc acttcctcaa ctccattctc tgctgcaacc
|
141661atactaatta tccacttatt gttccccaaa tattcaggca gcttcaggcc tccatccctt
|
141721ctccacctgc tgtctgccta gaaagcccat ccttccctac tcdccctcac ccatactcct
|
141781ctggggccaa ctcgatctaa atcatatttc agacttcacc ttctccagaa aactttctct
|
141841gtgcttctct tgatcagagc acctgcttca ttatgttgtg accacttatc tgctgcctgc
|
141901gctatgccac agacacctat ggtccagaac cagctcttat tcaactgaaa acagtgcatg
|
141961ctgcatctta ggtacttaca aataaatgct gcacaaaaca aagaggagta ctggtataga
|
142021aacaagtgac acaaatcaag tagtggctag ttaaaaggac tgaggcaaaa atacccagaa
|
142081cacttgttct aaacagcaaa ggcccaggtg cactggttac cacccctaca agatgactgg
|
142141aatactcatt ccctgggcag tgattttttt tttttttttt tttttgagat ggaatcttgc
|
142201tctgtagcta ggctggagtg cagtggcttg atctaggctc actgaaaatt ctgcctccgg
|
142261ggttcaagcg attctcctcc ctcagcctcc cgagtagctg ggactatagg cgcccaccac
|
142321tatgcctggc taattttttt tttttttaat ttttagcaga gatggggttt caccatgttg
|
142381cccaggctgg tctcgaactc ctgagctcag gcaattcacc cgcctcggcc tcccaaagtg
|
142441ctaggattac aggcgtgagc caccgcgcct ggtctgggca gtgatttttg actctttggt
|
142501tcactgctgt gtcctcagaa cttaaacagt acctggcatg gtaggagatg aataaatatt
|
142561tgcagaatag atgtcgaatg aatgacagac ctttcctagc actgctcagc taccgcagac
|
142621tgaacctagc acatgttcca tagcccagaa tttatccctc tacctctgta atgttaataa
|
142681caacagctaa catctactga gagcttaaca gatgccaggc actgttctga atgctttaca
|
142741tttgcttatt tccttaactc ttcacaacaa accctttgat acaggtactg ttttaccaaa
|
142801gggaagtgga gcacaatggc ccaaggtgac ccaggtagga aagagaagag ccaggcttca
|
142861aacccaggca gtcttgctcc aggatctggc tcagaccaac atacacagag aaaaatggct
|
142921gcacttgttc tgcctaaact tagagacctc atttggttgc tcgaacttgt ctgactttag
|
142981tcaaatatag aaacatgaga cttggcatga aagtctctgt tgacactttt ttttttttta
|
143041agtccagctg cctaatttat taagaacagg gcagaatttt ctgggtccag ggaaattcac
|
143101cacaggatac ttccaaatca ccctgtggtg atcagagcct gcccttccct cagcatacag
|
143161tatttcaccc ttcagaattt tccagaagac atttgagatg ttagagggaa gatgtgtgta
|
143221acaggtccaa atgggtctag ggagaaacgc ccataaaggc aactgaggag gccgggcgca
|
143281gtgggtcacg cctgtaatcc cagcactttg ggaagccaag gccggcggat cacaaggtca
|
143341ggagttagag accagcctga ccaacatggt gaaaccccat ctctactaaa aatacaaaaa
|
143401ttagccgggt gtggtggagg gtacctgtag tcccagctac ttgggaggct gagacagaag
|
143461aatcgcttga acccaggagg cggaggttgc agtgagctga gattgtgcca ctgcactcca
|
143521gcctgggcgg caagagtgaa actccgtctc aaaaaaaagg gcaactaagg agcaacccgg
|
143581attcagccac cacatggctg gaaggtcact attacagaat tgaaaggaca acaatagttt
|
143641ctgaccactg actactgacc accaaccata ttgcaagctg accacatgaa gtccctacca
|
143701cacatctaac tcatttaatc ttcacaaggt ctctgtgagg caggaattat tacctctgct
|
143761ttacagatga gggggaccat attcagaaag gctacgaaac gtgactaggg tcatacagct
|
143821ggtacttgtt agagccaaga tttgaatcca tccctatccg acttccaaag cctgtgttct
|
143881tgtcaccttc cagcccacct ggcctctaca catgtgctat gaaatcctcc tggtgcctgc
|
143941aaagaaattt atggtgaaac ctccaaattg aagcttattt ttttagttta tatacctccc
|
144001actcaggata aatagtcatc aaaatctcca aagtaaaaaa gaaagagtga gggaaaaaat
|
144061ggctaaaatc ttctgatcac aagcccatct gggatctttc agatgctgaa aattccagaa
|
144121ggctggatcg tcaagtttca gcttagaagt tgcaatcaga aatctttatt gaaataagtt
|
144181tatttccccc cgaggactct gctggtataa cagatgagag atgagagtgc ctactaggga
|
144241agaaagtggc gagaaagcga gtgatgctac tctatccggg aatctagaac aaacccacag
|
144301aggatccaca gggatggagt gtgtgtatgg ggaggtgggc cagatgaaac aagaaaggca
|
144361gaaagctaat ggttgttgaa attgaatgat ggacacttgg agttcattgt gccagtctat
|
144421ctgcttctct gtgtgtttga aaatttcaca catgtacaca aagccatgac cctccaacaa
|
144481gatgacatcc ttagatgtta atggcctggg ttccatgcct tcttagacac agcaccctta
|
144541tggggagagg tcaaggctga aatcaggtgg ttcctccacc ctgtcctggt ctgttccctg
|
144601ctggcccctc agcaagggtc tcagtacggc ccacagtcaa aaccctgcag caagttctgc
|
144661ttttatagaa gaccttctgt aagtggttga aactactgtt tttcagaatc aggaaggagc
|
144721attcaaaaga ctgctaaacc ctcaaacgag aacaagataa agaacaggct gaatcagcat
|
144781gcgacaggag cctggttagt gagttgactg aggttacttg tgagaatgat gtcactgtgt
|
144841ggaataagga agctggcaac accccagagc cagcgtgtgg ctgtgctggg agggagctgg
|
144901ccccttagtg ccgagtaaag gacaaactcc aggcagatat ttgtcagatt gtggccagac
|
144961acagtcttgt tcctttaaca ctttaaagga caaatggaaa gattagccaa gccctaatca
|
145021tctgaagaag ccatgtgtct gagaagtctg agggaagata tattgaaaac gatctcagtt
|
145081acgatgagac agctttgttt gatttacgca aaggcagaga cacaggtgta ctacatcctt
|
145141caggaagcaa gtttagaaat aagatctgca agtcatagga tgtgacaggt ctgcaaatcc
|
145201tgcaagtcac aggtcatcca cagtgggcta gtctagctgc ttcaagaatg ttgcccacga
|
145261aaggtgggtc atgggttcac agagcattcc tgtgttccat aaccacaggt ttcatcccta
|
145321actctggtca gcaacttttg aagtatatac caaggaccac aagttcaagg aagtgggcag
|
145381aagaaagaat gtgatgcagt catgcagatc catcgccact attcaagaca cagcccagag
|
145441cgccttccaa gggctttctg ttccactgag aataaaattc aaatcctcac aaaagatctc
|
145501agggtgcaac aggactacct ggcctctgct catctctgtt cactcatttc ctcctggccc
|
145561acctgctcta gcaatgttcc ttgaactcac caagctcatt tccactttag gacctttgca
|
145621cctgcagctc gctcttgctt tgatactatt ccctaagtct ttgcatgatt acacagatca
|
145681aacagatctc agaccaaagg tcgtcttctc aggcctttcc agaccattct agctaaagta
|
145741gcatccccag tcactttcta ttatatcttg ttttcttttt tatatcactt gttactatct
|
145801gatgttatta tttatttgat tgctttttag tgaactgtct ctctccagta gaatgtaagc
|
145861tccatgaggg cagattctgg actgtctggc tcaccgctgc acccacggaa cctaggataa
|
145921ggaatacctc ttgatgaata aataaccctc tggataggtc agtagctact ttcatatata
|
145981tatgaaggca ttttttttga tgaggcactt tttcttaata tatgaataag caaaaaaata
|
146041tagtatctat attcagtaaa aaattatttt gaaaaaacta aaatgatata aggttggggc
|
146101tgtcctggag aatctaaggt atctagtcat catatatatg aaattcaact tttccattgt
|
146161ttgataaatg ttcctgatga ctcatgtgtc tttagcacta gtttatctgt caaatggtca
|
146221ctggtaagag aaagagcgct cgctgtgaag ggatgggatt cctgaatggg gatctggata
|
146281cacagctggg tttgtgtgtt catgcatgtg cacaagcacc tgcagctcag aatctacaac
|
146341caacagctct tagagtcagt gtggccttgg tatactttgt tttgtatcct ttaggggtgt
|
146401gtgtctccaa ctttaacgta caagtcaatc acctggggat cttcttaaaa tgcagattcc
|
146461aattccaggg tggggtctga gattttatat ttctaattag cgcttactca ggtgacatct
|
146521gtgctgctgg ccagaggctc acactttggc aaatctctag tactgcaaaa ttgccgtctg
|
146581agaaacatgc ctccagatta gctaagaaag gaagcgctaa ccacagggga cttggtcccc
|
146641aagacccaaa aatatagaga acctaatttc aaacaagcag aaaggaactt ctctggaaag
|
146701agacgactca gctttcttca tttgtaataa accaaatctg taaacactta aaatggaatc
|
146761atttctaaat gctgacttgt gtgcggatct gggacactgt ttaattccag tatgggactg
|
146821taaaatacat attcttttac aagtttcaca tttacaactc ttgggacatg agaaaggaga
|
146881aagctttgcc aattctgtgt agcaatggaa ctaacatgga ccaatttccc ccatctaatt
|
146941gtcttgctcc aggtataaaa ctagttgttt ttttttttct ggtttctcct ttgaaagttt
|
147001cccatcctta ctaccaaccc cacaaccccc agccccctag tccaggctcc agggaggagc
|
147061tcaagctgat gggtgagcct ctgatataat tgttctggtg agtgatgagc ctgttgtgac
|
147121cttctcccac ttggctgctg accacgtgag agggcagggc tggtccagag tcctcacccg
|
147181acctgagcgt ccaactgcaa ctgtatgttc cggcagcttt aataggactc tgtgctgccc
|
147241gtattattca tagcagttgt taatgtgcct ctctccttgg gatcctgggg tgactgaagg
|
147301gcaggactgg gcattcctgt gtcctttagc aaccttccaa tagcaatgac tggacatgat
|
147361ccatcattgt ccacagcaac ctccctccca gtacacaaaa atgtcagaaa gcaaacctgg
|
147421cttttttcct ccagtttttt gtgttcctta agaaKctgct ccacgtgcat cacgctgtct
|
147481ccaatgcctg taaactctgc ttgctcttcc agcaaattat ccagggcaag cttagcctac
|
147541aagaaacatt agaacagtcc agaagtaaac caacactcac tcacctgaag gtataggttt
|
147601gttatgcttc aagaaaactc aaaattccaa aaaggattca agacttgtat atatctatat
|
147661atgttaaaaa tttttttttt gcagctcact aactttcaaa
Following is a KIAA0861 genomic nucleotide sequence that includes the KIAA0861 SNP “KIAA861-AA” (SEQ ID NO:).
|
+TL,1GTGCCTTTCTGAACCCTGTGACCCAGCAGCCTCCATCAACTCGTCCTACCTGCCATGCACAGCTCCTCTGTGCCCCTGTACCTGAG
CTCATGCTATTCCCTCTGCCAGGATGCCCTTCTCCTTCTCCACCAGGAGAAGAACACTTGCCAGTAAGACCCAGTTCTAATGTCAC
CCCTTCCTGACGGTATCAGGAAGAGTCA[G/C]TGATGGTGTTTTATGCTCCCAGAGAATTTGCCACATTGTGTTGTGATTATTTT
TCCACATCTGTCTCCCCCACTGGAATGAGAGCCTCACTCATCTTCATACCTCCCTGGTCTCTACCTGGTGCCAGAACCATCCTCAG
GGCAGGGGAATGCTCAGGAAATAGATATTGAATAAAATAAGTGTATCCATCCATCCATCCA
Following is a NUMA1 region genomic nucleotide sequence (SEQ ID NO: 4).
|
>11:71420751-71612100
1cctgccatggggcctggcacatagtagcctgctctgaatttttgttgaatgaatgaatct
|
61cagcaaatttataattttccaataaacaatacttccttcttgagtcacaaagcagccact
|
121gcctgtataattctttttattttattcaaattcgtttctcatttgatcctccccaccagc
|
181ttgtgaggtaatttaatatctgYactcaacagaaaaagagattttctcattcattcaaat
|
241aagcacctactgtgtgccaggccctgtgctgagtgctggggatacagagctggataagac
|
301atggtccctgccctcaaggagtactctgtttaatggaggagatggacaagaaagctcctg
|
361ttgcagtgcagttggtaagtgctatgacagaggtttgtgtaggtccaagagagcttgact
|
421ggccagcctcaaagctgtgaccacctgatccaaagtctttcaaattgtagattgctcttc
|
481ttcctattcttcttatgttctactttcctgcaagcctttctctggccttctggagtttca
|
541ttgtataaggtaaaataggtgatccataagttcctctctggctttggtagtttactttaa
|
601aggccactgtggaagatacaggatgtggagccagatgaatgtggattgggacccctagcc
|
661ctgccacttgttcactgtatgaccttacctttctgagccttgaagtcttcatccctaaaa
|
721atgggacaataattgctacctcacatagggtgataagatgatatgaagaaaaagtgcaat
|
781agaacaatgtaagagtcaccaaggacaccacaaacagtgccaacttctggctaaaataat
|
841tgaaaatatgtctgtaatacagaggatttttataatagtaactactagctttttttttga
|
901gatggagtctcgctctgtcgcccaggctggagtgcagtggcacgatctcggctcactcgt
|
961gcaagctccgcctcctgggttcacaccattttcctgcctcagcctcccaagtagctggga
|
1021ctacaggcacccgccaccacacctggctaattttttgtacttttttagtagagacagggt
|
1081ttccccgtgttagccaggatgtctcgatctcctgacctcatgatctgcctgcctcaacct
|
1141cccaaagtgctgggattacaggcatgagccaccgtgcctggccagtaactactagctatt
|
1201tatttatttatttagagacagggtctcactctgtcRcccaggctggagtgcagttcactg
|
1261caacctctgcctcccaggcttaggcgattctcctggcttagcctcccaagtagctgggac
|
1321tacaggtgtgtgccgccacacccggctaatttttttttttttttttttttttttgtctat
|
1381ttttagtagagacagggtttcaccatgttggccaggctgacctcaagtgatctgcccgcc
|
1441tcgggctcccaaagtgctggaattacaagtgtgagccaccacgcccagccctgtaactaa
|
1501catttgatagtgctttacaatttcaaagcactttttaaaaatagagatgaggtcgcactc
|
1561tgtcgcccaggctagagtgcagtgccatgatcacaactcactgcagcctcatcctcctag
|
1621gctcaaccaattttcccatctcagtctctgtagtagctgggactacaggcatgctccacc
|
1681ttgtctggctattttttaatttttatttttagtagagacaaggtcttactgagtttccta
|
1741ggctggtctcgaactcctgagctcaaaSaatcctcccacttcagcctcccaaagtgttgg
|
1801gattccaggtgtgagccattgtgcctgccctcaaagcacttttgtgaacatccttattta
|
1861tacatgtagcatttcatgaacatgtattatataccaggaaatgggctctgtacaacccag
|
1921taaaaaaggtagcagggttttcctgttttacaaagaaaatcacctctcttgtctcaaaga
|
1981ggtgatttgacttatctgaggttatccagctactaaaacatcacttaatccatattgagt
|
2041tttttgacctaaaatttcacatccttttcaccgtgtctctctcttttgtgatcagtgcaa
|
2101Wccctggagaatagagctgtgtgtgttctttaagacaacactagaaggaagatatttggg
|
2161acctttccctagcctgagaaaccatcactgcttgcctggccacagcaaggaggcatgggc
|
2221agggaaggaccttgactttcctccctagggttcagcagggttggtagtaacctagtcagc
|
2281tctcaggaaccacacaggcttgtgctggttattcagacagattactaaattgttcattag
|
2341ctcccatcacagatagaatagtggctcctgatgacagggacctactcttgtagcatttaa
|
2401aaggctctggtttggccaagcaccagtggcttatgcctgtaatcccagcactttgggagg
|
2461ctgaggtgggaggatcccttgagcctaggagttctagaccagtctgggcaacattgcaag
|
2521accccatctctagccaaaaaaaaacaaaaaaaaaggccctggttccttcagggaaccatc
|
2581tttcttgctgagtctagtagctgggatccaccaattaggttgtacactgtcttcattggc
|
2641tcctggggcacactactcctccttcaggagcatgaacaaccccattctacttcaccacca
|
2701ccacacactttcatccaactcaaaggtacttcttaagtgcctctctcccttctccctcag
|
2761aagaaaattcatttcagaagcaaattcattacacatcatttctttcatttttggcctgtg
|
2821gataggagcaaagctgtattcagactaaccgggcccaggtacaaacaacctgtagctcat
|
2881tctacctctgattcatctcttgaattctgtttctgaacaactagccttccctgcctgtta
|
2941atcttctgagcatagttgtgtttaatactttttacttcctcatttgaggtgacatagctg
|
3001tctaaggtcagctgtgctccttctttgaggcagaaactgcctttttaggaatcttttcct
|
3061tggtctgaaaccatgaaaatacaaagcatagctgggtgtggtggctcacgcctataatcc
|
3121aaacactttgggaggctgaggcgagYggatcatgtggtcaggaattcgagaccagcctgg
|
3181ccaatatggtgaaaccccgtctctactaaaaaaaatataaaaattagccgggtgtggtgg
|
3241tgggcacctgtggtcccagctactcaggaggctgaggcagaagaatcgcttgaactcagg
|
3301aggtggaggttgcagtgagctgagattgtgccactgcactccagcttgggtgacagagcg
|
3361agactctcatctcaaaaaaaaaaaaaaaaaaaagaaaaaaaatacaaagccctagttctt
|
3421gagtatatggaggcatttctgcagttaagggagtgagcagctttggatagtaactgaagt
|
3481tgctcagtaagtcctgagcaaagaccctggtgtccccattgatgtgagaataaaggattc
|
3541tggtgatcaggaccattaaggccagaatctctgtgtcagctgcactaaccttctctcctt
|
3601tccccaggttggtttataagtggttcctgctaatctataaaatcagctatgccactggca
|
3661ttgttggctacatggctgtcatgtttaccctctttggtcttaacttattattcaagtgag
|
3721taccctttgtttttgtttttgctggagtttggggaggagtgactgttgagatgtacctct
|
3781tgttgcaagtcgtggttattaacaggagggacgtaatatccaggataggagacttgggtg
|
3841ctgtggggggatgggagaagacaggctctccatgatttgttctggcagaaagcaaggaat
|
3901gtctgaatatatacaaagtcagagtcctaaatcatattttccaaggctttatattttagt
|
3961ggaaaagtctagtaaccaaagtaagcataataattatcataacctgctatccataattct
|
4021atcaccttaacagagctgtttttctcgtcagtgtgtactgttcatttgcagcatccactc
|
4081tgcatgaatggccttacgttcaactaggccaggggttggcaaactgtgccctctgtgcca
|
4141aatcagcccacaacctgttattataaaatgaagttttactggaacatagtcatgcccatt
|
4201catttatatattgcctgtggctgtttttccactaaaacagcagagttgaatagttgtgat
|
4261aaagaccatatgggctacaaaacctaaaatatttaccatctggccctttataggaaaagt
|
4321ttgctgactcttgggctagaccgtctacctacatgaccgtggttggctacagctagcaac
|
4381aaattgacttagaagaatacaaaataaataatagagcagagtggtgtctgcaagtcttca
|
4441cagtagactcagagcttaggtgtgagggaatgagaYgacacagatgggtgtggaagccac
|
4501ctggcctaggagccccattcccccaggaacacatccagtttcaagaatgtcgcagtccag
|
4561atgtgttgtactaatcacaggtcataagcagtgttgcctgtaatatagctgacattcgac
|
4621aagatttctaaggaaacagttctggaaagttaacctgtggatgttaagtcctgcttcatt
|
4681gttgggcacttaggttgttttcaatttagtattatcccagataacgctgctctgttgctt
|
4741cctaagggtgcattcctagggatggaattttggctgttgcttcagttgtcataagccttc
|
4801caaaagatctttattagcttacaggtcctcccaccccgaattgagtcagatgccaagaaa
|
4861tcctgagctcagagactggagcatgcagtgagtcaatgaggcagatgagggtggaaataa
|
4921tgctttcctggatgaaatactggtggctgtgggctgtggatcaagaggagccctaagcct
|
4981acgacagtgcactgaagctagagatctaggattcaaatttaagataatgaatgggatgat
|
5041cactggcctcttccctgagcctagttatattgtaggcaggagtctctgaaaggagtttat
|
5101tttaggacaagtaaaaataaatcctggccaggtgtggtggctctcacttgtaatcccagc
|
5161tatttggaaggctgaggcaggaggactgcttgaggccaggagttcaagaccaagctgggc
|
5221aacatagtgagactctcaactcttaaaaaaaaaaaaaaagaaagaaagaaagaaaattag
|
5281ctgggtgtagcagtgtgcacctgtatccccagctactcaggaggctgaggtgggagaatt
|
5341gcttgagcccagaagttcaaggctgcagtgagctatgattgtgccactgcactccagctc
|
5401aggtgacaaagggagacccccatctcgaaaaaaataaaaataaataaatcctattttata
|
5461tagtgagagtgcactcatgaaattctttcttctaggggtagtacaggctgaaggaataaa
|
5521caggctcctgaagggtttagaggaattcatcactgtagagtcaaacacatcttgtcaaag
|
5581aaaacagatatctcctggtaactttctaacctgtatggttaaaaaataaaataaaaatca
|
5641agattctgcattatgggattctgcattatggttttttgtttgtttgtttgtttgtttgtt
|
5701tgttttgagatggagtcttgctttgtcgcctaggctagagtgcagtggctcactgcaacc
|
5761tccacctcccgagtagtggggtcaaatgattctcctgcctcagcctcctgaatagctggg
|
5821actacaggcatgagccaccacacccggctaatttttatatttttagtaaggatggggttt
|
5881caccatgctggcgaggctggtttcgaactcctgacctcaggtgatccacctgccttggcc
|
5941tcccataagtgttaggattacaggtgtgagccaccacgcctggcctctgcattaagtttt
|
6001aaagataattcttctataattacagtttctttttacttgcctgaactctacaatgaggaa
|
6061aacagaattgagaatcttgatcatttttgtgctactgatcaaattaagtggtgtaagatc
|
6121aatRatttctagtgagttaaatattcagggttcataagcaaatgcagctttgtatataaa
|
6181tataatttataactaagcacatacatacggttctttgtacaaatattttaacagataatt
|
6241ttctataacaaagatttatagactcaaggttgcaaattatcggtccttggaattattaaa
|
6301acaaaccttctgatgttataggcaagatctttatccttcttgttaaatagacttggacca
|
6361aaatttaactttgatgatatgatacagattatttatatttgtagtttataattttatagt
|
6421aactgctatatattaataaatatttactaattttatctttttttcttaaacctgtgtttg
|
6481acaagctgtttctgtaaaggtccaaatagtaaatattttaggtcttatgggacaataggc
|
6541caaatctaggatatcatgtaggtacttatataacaagagaaaaaactcctaccctgtccc
|
6601accctctttgcctggggaaggggccaggtctcaggtagtgggcatgctttgtgctctgtt
|
6661gtcataagctgagacaatctcagaaagaggggcatgtggccaccggagtaattttcagYc
|
6721tctgcaccagtgacacccagattctggcatgccctttcctccttatggatggctcagctg
|
6781tttcaacttgagtggctagctggaagagagacagctcagcaaggcagctcacttagtgtc
|
6841cagaagttaccaacagtggagtccccactatgtaggtcccgatgagcataggtcctgggt
|
6901agctgcaagtcattgtcaccagttRggggaggcaaggactaagagcagagtgaggaaaag
|
6961gggtaggaggggatactgtagcttggtcttcacagcctacagtgctagctagcctcctca
|
7021agaggtgttcatgggccatataaaaatagacagcagactSgatttggtcatagtttgccc
|
7081RcacttgctYtagcctttgggccttctcgctttgggccctgccttgtgtgtcccagagta
|
7141gtaatccatagaagatatgtctcagggtgggtctttctagctctaatgcttcccttgcag
|
7201gatcaaaccagaagatgccatggactttggcatctcccttctcttctatggcctctacta
|
7261tggagttctggaacgggactttgcagaaatgtgtgcagactacatggcatctaccatagg
|
7321ggtaagttcatccgggttcttaaatactgcttcttgacacctccaaattgctcaagttga
|
7381tgtcacttgtttaatggaagagaaaggcactagggtgagataagccacataaaatccttc
|
7441aagatgtgcatatgcatggacattccttccttaaagtttggaaagcaacacagccataaa
|
7501aaaagataaaaccatgtgcgttgcagcaacatgccagctggaggcctttatcataagcca
|
7561gttaatgcaggaacagaaaaccaaatactgcatgttcttacttataagtgggaactaaac
|
7621attggatattcatggacataaagatggcaacagtaggcactggggactacaagaggagga
|
7681gggagtggggacaacRgttgaaaaactatctgttaggtaactgtgctcattacatgggca
|
7741acaggatcattcgcaccccagacctcagtatcacgcagtatgcccatgtaacaaacctgc
|
7801acatgtaccctctgaatctaaaataaaagttgaaattattaaaaaaaaaattagccagat
|
7861ctcagatgtaccctataatttttctctttagggccattataggaaagagccactttatcc
|
7921agcaggaagttaacattcattcagtagatactttttaatgcctgctatgtgtctagacac
|
7981atagctatRtgccagaattacaaaagtgtacaaaaataaacatggtttttgcccagataa
|
8041actttactcttaggtgggagagatggctattacagtaacaaacacagataaaaataaaat
|
8101tacaactttaataagcattatgtaggaaaggttcatgatgctgtaaacacatgtagtagt
|
8161gtcatttgacctagtcttggggctcaaagatggcttccttgaagaagtgactatggagct
|
8221gacttgaacaatgaatagcagttaagtggatgaagtgagaaccaggcagaggaaagagca
|
8281ttcataagagtcctgtcacgggagaaagtgtgggtgtttttgaggaactaagaccattgc
|
8341ggttgtatggccaagaagtgcctggagaagtagtgactagactagaaaaaagcctgtggg
|
8401ccaaattaaagattttgatttttatgctaaaaatcctgggaggggccgggcacagtggct
|
8461cactttgggaggctgaggcaggcagattgcttgagcccaggagttcaagaccagcctgag
|
8521caccatagtgagaccccatctctacaaaaaaatgagacaaaaaaaaaaaaaacctagccg
|
8581ggcgtggtggcacatgcctgtagtcccagctactttggagaccaaggtgggaagtcactt
|
8641gagccttgcagtgagcttgttcatgccaccaaactccagcctgggcaacagagcaagacg
|
8701ttgtctctaaataagtaaaaattcacaaaatgtataataatcatgcaaaggcacaacaat
|
8761aaatgatggggcacaaaagtgcttagtccatattggtaattgtttttgaactgcacagtg
|
8821gtaggagttgctccttacaatttttactttgtgaactcttattccttgatttaacccaca
|
8881gccgctacaacaacagccactgtcacttactgctttaccaaaaattggggaagctttcat
|
8941acttgctttgttaatctttaactgtatgtgtaaagctacacatttcatttcaacatttaa
|
9001tattaaaagtgttttgagtctttacttaagagacaatttggtgtctcttaaatagaggtt
|
9061tagtgatgtctttgtgacagaaatatgacacaggaactgaactcttgtttctatcaatta
|
9121gcctgtggtaaaattggttttgttatatgtcgtttcatttaaagtcacagtttccaagaa
|
9181actgtcagtgaagtgaggacatactgtatttgagaagtattttggacttagatatagttt
|
9241ggttctgaagactgaagggaaaaatacaaaggaaatataggtttcaaagctgagatttct
|
9301gattcggcaactgcttggatggtagtacctttcactgagataggaaatgctgcaagagca
|
9361gcaggtggacatcacggagagatgcttaaatatgggtaaattaacaRccaatctgagaaa
|
9421cgcaagtaaatatttctattttttttttcagaatggaaatatatctttattgttttgctg
|
9481tttataaaagtagtatgttctctttgtaattatttaaacaacacagaagtgctccctgtc
|
9541tcagtgtcatcccccaagaccccaccccaagaaggaatatttccatcaccttgggtaact
|
9601ttaatctagtaccgtttaaggccagggactttgtccctcagtatcatgggaatattctaa
|
9661ttttttctctactggatcaaattgaaaacagtacattgKatcactttattgacagtttat
|
9721taggttcctttttgaacaactgtcttgtgctttaccttcatttccctcttacctatttgt
|
9781gtagacattggatcttcctttaaccagtttactccccagaagagatttctagaccatgtc
|
9841accattttgaccattttgaagtatacaattcatgcattaattacatttgcagtgttctgc
|
9901aacaWtttcactgtctaattccaaaatttttcttcatcccaaacagaaactctgcccatt
|
9961aagcagtaactcattaccccttcYcacagccctggtttacctctaatatactttccatct
|
10021ctgtgaacatgcctattgtagatatttcatgtaaatggaatcatacaatatttgtccctt
|
10081tggcttttttcacttagcgtagtgttttcagagttcatccatgtatagaatgtatcattc
|
10141ctttatatggctgaatagtattccattgtgtgtgacaccgcatttggtttattcattcat
|
10201ctgtggataggcacttgagttgtttccactttttggctactgtgagtaacgctgtgagca
|
10261ctggcgtttaagtgtgtttagtccctagtttcatatcttttgggtttataccgagaatgg
|
10321aattgcttggtcatttggtaattttatgtttaactttttgaggacatgccaaactctttg
|
10381ctttcttaattatgataatgcttaagtgaatatctgtattcatgaagcttctttgacact
|
10441tcctctttttttttttttttttgagatggagtctcggtctgttgcccaggctggagtgca
|
10501gtggtgcgatctcggctcactgcaagctctgcctcccgggttcacgccattctcctgcct
|
10561cagcctcctgagtagctgggactacaggcgccccccaccatgcctggctaattttttgta
|
10621tttttagtagagacggggtttcactgtgttagttaggatgctctcgatctcctgacctcg
|
10681tgatccgccctccttggcctcccaaagtgctggggttacaggcgtcagccaccgcgccca
|
10741gcctcctcttatttctttaaattccttgaagtgaaattaatgggtcaaaaggtgcaacaa
|
10801tttgagataccatgctaaatcctatctgaaaggcttgaaccccttttgctgctgccacaa
|
10861atgtctgagaatgcccttgtcaccaaaccaacatggcacttaatatttcactgttttaaa
|
10921tgttggagaatattgttgtccatttctggtggaaccatagtctggcgacagaatggcttg
|
10981cctgacacagcttttgatcaccagccccaagtccttctccctccccttccccttatcctt
|
11041tggtgctgatccagcccagtttataggttctgttacatctaacttcccaactgtctctag
|
11101tctggtcacttctccccatctgcccagcaaagatgaggtcgatttgacttgtaaaagatt
|
11161accttttctaaacagtttaaaaaaaaaaagatgtcctctaactctgggcctcccgctgcc
|
11221actgtgcctcttctctagaaggcctgaggtctctgtggagcttcctactttggctgcttc
|
11281tcacatcttttcctatctttccttcctgctattctccttcagttctacagcgagtcgggc
|
11341atgcctaccaaacatctttcagacagtgtgtgtgctgtgtgtgggcagcagatctttgtg
|
11401gacgtcagtgaagaggggatcattgagaacacgtataggctgtcctgcaatcatgtgtat
|
11461cctgcctcgagctcctgggccacatctctcctgcaatctgcacactgtagtgagagagag
|
11521aaagagggtggtcatgaccctaggcatgctgtccagacccttgagtgtaggagagccaca
|
11581agagggccaccttccctaccctttcccacagatcagagccactcttaggtaaacagtggt
|
11641tacaacctggctgggtctgagaggaacctgaggctgcagctagtgaggctgtgctagcag
|
11701acctgagatctgaccagtcacaggggaagaggaccctctaatgggatccctcagtttagc
|
11761atcatcctctgttctgaataacacttgtaatatttatcatgtatttacccagctcccatt
|
11821ctctgcctatgttgggaaagccatgtattgtctccattttgccccataacagtcttgtga
|
11881gatagggatcattatccttacttcacatgtgaggaaacaggttcagacacagggacttgc
|
11941ccaacattacagagctgataaagagcgaaggcaggatttgaacctttcaaagactgtctg
|
12001gggctggagtgccgccctggctctcaccatttcccttgaccagcggtgctcagcttccac
|
12061gagttctgcatccgtggctggtgcatcgtgggaaagaagcaaacgtgtccctactgcaaa
|
12121gagaaggtagacctcaagaggatgttcagcaatccgtatcctttattggggtcgttgttg
|
12181ggagtgggctgtgggaagaaagtactggccagtgtgacctgcatttgggtcctcctgggg
|
12241ccctcacttctgcccccaaccagaacatgtcaaaccatggtgggaagctgagctgctagt
|
12301cctgcccccatgatacaaccccagtttccctattctaggattattgcctattctcagcct
|
12361ccttgcagccattgtcacggatagatagacttgtgtcagcctcaggctgtgttatcttac
|
12421actggcagttccttcttagagaaggtgttacaggaggccctccctgcatgttagtcatgg
|
12481ggaactaggatttatctctatacctctctcagggctgccctgcctccagtaccagtcccc
|
12541tctatctgcctcccaccttctctgcattcagctctttaccccaacagacaggctgtgagg
|
12601aggaagaggagggggagggcaaagttgggagggctgcctgagtaggaagtgaggctgggc
|
12661ccttccagaaagcagcctccattcctctaggctgtggagcagctggaaagtggggcagac
|
12721ccagggagccccaccacccatgctagatcactcctggcagctcttgcacagagtctcttt
|
12781tctttaacacactgacagctgggagaggcctcacgtcatgtatgggcaactgctggactg
|
12841gcttcgatacttggtagcctggcagcctgtcatcattggtgtagtccaaggcatcaacta
|
12901catcctgggcctggaatagtgatgaagagcatcagtggaaaacccaccccacacgccatg
|
12961gacctcagggcactctcctccctgcccacaaagacctcctgggtgggaaagactcaaagg
|
13021ggYgcttgggccactcaggacccctcYggctgtgtcggactggggagggatatgatggag
|
13081agccagccagtggggctgtcagcagtggggggctttttaaaagaaaactattttgatgaa
|
13141tatatttaaaaaacctttttttattgtggagcataggaattgcccccctccaggcttcac
|
13201cctccctgcctaagcagggtgggggcagagccatgacatttttggtttaaaggagccttc
|
13261tcatctctggccgagaacactgctgggctcccaggtagctgaaggcctcagcccacccac
|
13321tcccttcttccctgtgtggggctcaagcctggtgcacttagtatagaagagctaacgtac
|
13381tcaggcttgtgccacgggtgagcactgaggccccaggtgtcctccctcccccactgtctg
|
13441ggacacaggacaggtgttgcgtctgactctgtctccccctgtccaagagctataggctgg
|
13501ttgaggcaagtggaaccttatcagtgacttggccaacaagggaagccttggggcctcaga
|
13561attcattgaaRatttgttttgggacaactggaagaatcagcaccatggatactcgcccgt
|
13621gggcagggctgtggtcagccaagaatagaggtcatatagttgggccatggggcaattgtt
|
13681ggcagccatgactgacggccccttgtgcaagctcattcttcagtggatccttcagtggag
|
13741tggtgacacgtgccagcggtcactctgccacatcacttccttcttgaaagcctaagagtg
|
13801cgtatgcgtgtgtgtgtgtgtgtgtgtgtgtacgtgaggcagaagaatatgacagatgtc
|
13861agcttctccctgtgtcagatgatatgtccttgaagctggcaggggattcccagtccaggg
|
13921aatatccctacatgatttttgtcattcatgggtcctccctgggcctgacaacgggagtgg
|
13981tgggtgggtgagaacaggttctgagagggggcttctaggaaggccccagccctagtccta
|
14041ggcgacttgaataaagtgggaggtcaaacatgggccttcggcattKggtttctagggaat
|
14101atggctcagtagggcctgccccttcaagggcagcaagaacgaagcaggatgttgtcactc
|
14161ccgtctgaataaagctccatgagctgggttggaaagctgaacatttatcttgctttcttc
|
14221ttcccacctctttccctggggtccccaggggtgtcttgcctttgttaacccccatcggag
|
14281acctgagggtctgggggtggttgggcctgcctttctgctgttcccagctgttccccWgct
|
14341gacatccctaggagtggtggaatgccaggctcctgtcctgtggcctgggggcctggggca
|
14401tcattgggcctgccttcagactgaggttgctctatgttctcactgcctgaggacagtgtc
|
14461cYgccaccacctgccttcctgaggaccacactcaggctcggcttctcttccccagctRtg
|
14521gcttcccatggtaccctgctgcttatgccacctgtggggctgttcccctcctcagagagg
|
14581ggaatggggctggtcagaggacctagggatcacccttccttttactttttccccccaccc
|
14641ccctgtcaggctcaggtgagaagccgaggccaggctgtccaaagctcttttcatRtgtaa
|
14701cagttctgagtcccttgacctccccccttggcctgactctggtctcggttccactaagac
|
14761agagtcctgtcatctttccctaccatcccccactggactgtctctctcagaaaccccagg
|
14821cagccttgcYtcctgacctaactcctggagatgctggtgttcttgggaggaatttctcct
|
14881gcatcttacatgctagaagcccctggggcaggaggtagggggaggaattgagaggaggaa
|
14941aaacatgaactagacacctagagaagaaggatgtgacttgtagtatcctatgtctaaatt
|
15001aggaatatgaatctggtttttctacaagaagtttgagatcacagctgactgtgttcctga
|
15061tgcatccaccaaacccagttccatctgtgggcctccctggctctgtcaccagccgttgca
|
15121ccctcccaatcacaggagtcacaaacctcagacatgcagctcctgtccacacttaatata
|
15181tgcatgcattggatcacccagccctggtctttctgcctccatggataactgcatgaccct
|
15241gagagaaaacctccttagatttagcatcctaggttcctcacMcgcctcaccctgaatcct
|
15301ggccctcccgcagccccagcgccatttgtcccatcagtgacaagattcatattctgatgt
|
15361agactctgttgccagagccagtgttgagccagtccgcctcttccccgggaagtgcctgcc
|
15421cttccctcctgttagRgttggctctcgagcttgtgtgccagttcctgggttggccgtgag
|
15481agttctacagacaaggaggaagtgctctcggtgtatttcctgtggtgggttcacacgcag
|
15541ctagacacagctaacttgagtcttggagctcctagagggaagcttctggaaaggaaggct
|
15601cttcaggacctcttaggagccaggtaggagtctgggactactagtgaacctagacctgtg
|
15661gctctggccagaggggctaggatgagagacagagggtgtgatggtgggtgctgggagatg
|
15721tagccgaccttggggctggtggctRggKgagtgggtagcctgggaaaggccaggatgtgg
|
15781acggactggtatggcaYtgagcctgaagtggtccaacttggggttccccagtgcctagga
|
15841aagttgtccccttgaatgtcagtgtgaaggtgaaggaggaagcagatgcctgttcatatg
|
15901gaaacaaagacctggctgtgaagaggggaggcggacaccaaagtcctgacacttgggcgg
|
15961gacagaattgatctgtgagagactcatctagttcataccctaggtgaccctgggggtggc
|
16021atgggggtagattagMgatcccagtctggtatcctctggagagtaggagtcccaggagct
|
16081gaaggtttctggccactgaactttggctaaagcagaggtgtcacagctgctcaagattcc
|
16141ctggttaaaaagtgaaagtgaaatagagggtcggggcagtgctttcccagaaggattgct
|
16201cggcatcctgcccttcccagaagcagctctggtgctgaagagagcactgcctccctgtgt
|
16261gactgggtgagtccatattctctctttgggtctcaattttgccttccctaatgaaggggt
|
16321aagattggactaggtaagcatcttacaaccatttgtggtcatgagagctggggtggggaa
|
16381ggattgtcacttgacccccccagctctgtttctaagtgctgaaagagctccaggctatgc
|
16441tacgggaggagaagccagctactgaggaaaagccagctactgagaaaaagcgggagtggt
|
16501ttaccattctcctcccccacctttcaccagagaagaggacgttgtcacagataaagagcc
|
16561aggctcaccagctcctgacgcatgcatcatgaccatgagacacaactggacaccaggtag
|
16621gccttggggctacgcatgggcaggcRgggtagggtgaggtctatgaacagaatggagcaa
|
16681tgggctaacccggagccttcactccaaggcaaRccacccagcgcacctggtgctgttgct
|
16741ttaagaacctgggcagatattgtagctctggctccagtctaaagcttctctgtactctgt
|
16801tcaataaagggctaaggggtgggtgctgaggggtccctcttcccgctctgattccctgRc
|
16861tagaacccagacatctctgggctggagttacatccttacccgggcagcccactNtgtctc
|
16921cagagccgctgacctgtaactgtcctttcctcagacctcagccctttgtgggtcctgctc
|
16981ctgtgtgcccacgtcgtcactctcctggtcagagccacacctgtctcgcagaccaccaca
|
17041gctgccactgcctcagttagaagcacaaaggacccctgcccctcccagcccccagtgttc
|
17101ccagcagctaagcagtgtccagcattggaagtgacctggccagaggtggaagtgccactg
|
17161agtaagaagcacagtggtggagggtgggctatgggcacagaggttcccagggtcgggttg
|
17221actcctgagcgccagtccccttctgcccatgtaccaccagctgagccagctgggctgagc
|
17281acgcaccattctccctccccaacccagtgtcatgggtgcaggcttggcgcagctcccaag
|
17341atgctccctatcaaataggacagagaactcaagacataagtaatggtcacaggacctccc
|
17401agagccttggttgcagtggacYccaaggccagcccctccacccagagcctgctggcctct
|
17461ggccatctcagaggagcagcagccatccagcactgcctYtgtcacctgggctcccaagtc
|
17521accgaggctgggcactagaaaaggtcatcctgaggagacaggttcagaagaggattcatc
|
17581acgtgaaccaaggaccattcctcacattccccgtgtttagggctagggcctctcggagac
|
17641aactgSacttctgtaacggacgttcccacctaggtggtgtRcagagcagttctctaggtt
|
17701ccagatgcatggggactggggggagctggcagRgagggcacagcagagcagggtagggga
|
17761agggcctgctcttctgaagagctaactgctgcctgtgtccctagatggaacgctgagctt
|
17821atcctgtgtggcctgcagccRcttccccaacttcagcatcctctactggctgggcaatgg
|
17881ttccttcattgagcacctcccaggccgactgtgggaggggagcaccaggtgagggtcgca
|
17941gcagccaggtgggtgggaaggaRgccttctgcggccttctcatgacctttccttcccttc
|
18001cgctccagccRggaacgtgggagcacaggtacgcagctgtgcaaggccttggtgctggag
|
18061cagctgacccctgccctgcacagcaccaacttctcctgtgtgctcgtggaccctgaacag
|
18121gttgtccagcgtcacgtcgtcctggcccagctctgggtgaggagcccaaggagaggcctc
|
18181caggaacaggaggagctctgcttccatatgtggggaggaaagggtgggctctgccagWgc
|
18241agcctgtgaactaatgcccagcattcctcaaggtcagccagacaaaaaggaacttaggtc
|
18301ttgggcagaggaggtgtagcctggggcaaagtgatgagatgtccctcctttccttggcct
|
18361gatccttgtctgccttcacttccctaggctgggctgagggcaaccttgccccccacccaa
|
18421gaagccctgccctccagccacagcagtccacagcagcagggttaagactcagcacagggc
|
18481cagcagcagcacaaccttgaccagagcttgggtcctacctgtctacctggagtgaacagt
|
18541ccctgactgcctgtaggctgcgtggatgMgcaacacaccccctccttctctgctttgggt
|
18601cccttctctcaccaaattcaaactccattcccacctacctagaaaatcacagcctcctta
|
18661taatgcctcctYctcctgccattctctctccacctatccattagccttcctaacRtccta
|
18721ctcctcacactgctctactgctcagaaaccaccaagactgttgatgccttagccttgcac
|
18781tccagggccctacctgcatttcccacatgactttctggaagcctcccaactattcttgct
|
18841tttcccagacagctcccactcccatgtctctgctcatttagtcccgtcttcctcaccgcc
|
18901ccagcaggggaacgctcaagcctggtYgaaatgctgcctcttcagtgaagtcatcctctt
|
18961tcagctctggccgcattctgcagacttcctatcttcgtgctgtatgttttttttttcccc
|
19021cttcactctaatggactgttccagggaagggatgggggcagcagctgcttcggatccaca
|
19081ctgtatctgtgtcatccccacatgggtcctcataaaggattattcaatggaggcatcctg
|
19141acatctgttcatttaggcttcagttccactcccaggaactttgcctgtcccacgagggag
|
19201tatgggagagagggactgccacacagaagctgaagacaacacctgcttcaggggaacaca
|
19261ggcgcNtgaaaaagaaaagagagaacagcYcataatgctccccgggagcagaggccacta
|
19321atggagagtgggaagagcctggaaagatgtggcctcaggaaaagggatgagagaaaggag
|
19381gtggtatggaagactcagcaggaacaaggtaggcttcaaagagcctatattcctcttttt
|
19441cccacaccgatcaagKcaactcagtactcacgggagaaaaatagactttatttacaagta
|
19501ataacatttaRaaaagatccatccccggcccttaaaaaccttcccatcactccaaatccc
|
19561accccagtgcaagtYtggggaaggtagggtRtgagctgctgctgaaggctgtcccccaac
|
19621cccactcctgagacaYagggcccatccgtcctgggaaagagcatcctctggcaggtgctc
|
19681ccaccaggtcagacccagtcctggacttcaagagtgagggcccctgctgggcccagccac
|
19741caggacagcaggaaccagggcctactcctYttatggtcccttctagatccagaggctaag
|
19801aggaagactggccaggcccaaggacccagccatcaaaaccagcctcaaatctggttgtga
|
19861tggagaagtgactttgctttaagaaaaaaggaggcaaggtagggagagcgcccacactgt
|
19921ccatgctccaggccccctgggccagctccgagaaggcgccagtgaaggaccagggaccag
|
19981gccagggtgcgggcaggcatcRctgtctctaggggtttggctactgttggcctgggagct
|
20041gagagaaggcactgagagggacagtaggcggaggaccaggtgaSgKcagcatcggggaca
|
20101caggtggggccactcactggtactggccctttagtgctttgcctgaaagagacacagtca
|
20161catggccagatgagaacttgcgatactagcctgcacccactggctgggaagatctcttcc
|
20221tgctcccacgcccctgtctggatccYctccctYgtgagccccagggttatcagttgctgg
|
20281ctgtgcctgagcagctctgRgtgctctccatgagaatggggccatctgtcttctctcctt
|
20341ggagaggagctaccaggacagggacacctcttaccccacaccctccagcagcctggcgtg
|
20401gccccatcttggatgctacttggtggggcggtctggggggtgcccatgctctcatcgggt
|
20461ttccctcccccatcctgccagtgcctctaccttgcccttggctcgaggggtggcaccaat
|
20521ggcggcagcagtggcggcRctggctgtggtggtggcaatgcgcggagaacggcgggttcc
|
20581actgcgagtgttgggggaagccttggacagggccttctttgaggctccccgccgcagaag
|
20641gctgttccctagcttcttgggtgtgttgaggatgctgaaggYcatcgactggcgccggtc
|
20701agcctgcaaggaagggctgtcagaccgggagacccaatgctgccttcccaggccagcgtg
|
20761ctgtgccacgctStaYcagcaaggtcccgccagggcgtcgcttcatcccccttcagcccc
|
20821agcctcacctgtttagtagaagctggagctgctttcttctgggcctcagtagtgctctgt
|
20881ttgcgcccttcatgtcggtctcgKggagtcatggggcRtgggaaacagctggtggccttc
|
20941ttagactatggagaagaggacagttaggcagacagtaRcaagaggagtcacatctgaagc
|
21001caggtgtcttgtcctctcagagctgagtggaccttgtaagtcaacgtgcaacctgctccc
|
21061cttcccaactctgggccagatccttcccttcccaacagttcccatccatgggtcaggccc
|
21121ttggagagagggaaagagagggggaagtgagggaaggagagagaaggctccctttagtcc
|
21181ttggtgagctgggcctgacctgagcacagtgctggagtaacacccaggagccaccgcgcc
|
21241tacctcaggagttccagggccctggtggKgctctagggagacccgtttgcgctgctgccg
|
21301ggtggtgatgccagtgccctcggctatctggattggctgcatgctggctcggcRcagggt
|
21361ctcttgggggtctccagttttcatctcctcatctgtgatggtgcccaggctcagggaagg
|
21421ctgcatgggtggaagaggtggtcagtggaccatagctgtatggagatggaggaggacctg
|
21481gggctgtYccagaactctacactcgcccgacacttatggtcgggacccttcctgcctcac
|
21541gaggtagaaagacacaaggcctcctttcctgttctgctttctacctaagccctgggcaaa
|
21601tggccacaagcagtgcagtcctgaccagattcctctctgagctcctgcctaccccMaggg
|
21661acttcacccctgagtgccctcccagctgtctgttccacctggaaacatgagaaggtcacc
|
21721ctccccctcctcggccagtcagtgatccagggccctagtgctcaggctagatcagcaggt
|
21781gggattccaaggRagggcagggatgggaggccctgcacagtgaccccaggcctcaccctg
|
21841gactccaggggatagcaggtcttcagatgtggggggcacactcgattgcgctgctgcagc
|
21901tctgcaatgcggttccagtcatccagctgctcaggctcatcctggcaagtgcccatgtag
|
21961aagctgttccttcctgtggaaggcagggaagtgggaacaaatgagcctggagtcggcagg
|
22021tcacctcctggccctggcatcttgccagcctttgctgccacctaccccataaacttgaag
|
22081cccRgcacaccagtctgattcagtgccgcaggtgcaggagtacggcacacagactatttc
|
22141tatcctaggggcttgctcaccaccttctccctggagagggcagaagaggtcacacgcaga
|
22201gactgctactacatcttaYtcacctgccaaggcttggtggccaacacccagaggaacaaa
|
22261ttaaggaccgggaattaattcccaggggctccctggtgcccaaaggacaagagcttccaa
|
22321gaagagtctggccagcctggcctttccagcagcccatcaccgcctgagaagggcatggag
|
22381gactccccacagctaagtgtcacaattgtgctgggaatcccgggcccttaactctggcta
|
22441agagtgcccccaacacagccagcccctagatgggcaggtaaggaaggccctgaggctgca
|
22501ggaaggaggggcaggtggagctggatggtagcaaggaggccagccttggatttttaaaaa
|
22561gctttcctcttttccctgtgccacgatccaccttccagtctaattttggggtatagtaag
|
22621tccctgtagtcccctcacctggaggggccccactggacaccccggcctgggaacgacgag
|
22681cagaactgcgagtggtggggcggtagccaggcaagctgagcagggctgagttgccataat
|
22741cgggagaacccaggcgagctagagactgagtagaggaggtggctcgcaggctagcctggg
|
22801aagcaggagcagacMgcgtgctgtagaacgatgagttggcgctgtctggctcttccaYat
|
22861ctagcttctggaagacagagtgaatctgttgcagYgtacagtccctggcactgtacagaa
|
22921gcttcccattcccttccgaagccctcagatcccacggcacatccatgtattcccaactgc
|
22981tttgcaaaggtccttaaagtgtgtgtctgcaagaaatgggccttgtcgacagaagccctc
|
23041acaaggtggtgctgatgttgtcaagactcttctacgcatttttttcatggagtctattca
|
23101taatgctttgaggtagggaatgcagagtgtttatcggcccattttggagatgaagtgcaa
|
23161agaaataaagtgactagccccaaatcacactgctaggaagtatcagagctggggctaggc
|
23221cccatgtctcctgactagtcaggctcatcccacagcctctgctgtccctcagtccaaact
|
23281tccagggcccttaccatgttccagaacttccccaacttcttggtagcagggggcacccta
|
23341aacacacaggtcccccctgctgtaccaggggcccctctcccctcctcccaaacctcccct
|
23401tcaagatgtggaaacaaaggcaagggcctgYagcctgtcaggcagtccactgggcagcaa
|
23461caatgcctctcagctgcatggggcatgctgggaggcacaggatgggctgcagcttcgcca
|
23521cgttctctcccttcaccctgcacaggctcagtgctacgcatggagagaatgctagcctta
|
23581gtcaggaggcagggatctaatcctagccctgcctttttcttcagaagtgcccttaaccaa
|
23641gtcactgccctttttaagacctctcagctttcccactgtaacatggactggctgctcatc
|
23701cctccctgctcctgactgagtgcccagtgcaaagatgcccttgagaggaagtgggaattg
|
23761ctgccctgcagcccctgtcccagcagcctgaccttggtcatggtgatgttgatgatctgc
|
23821gtggtgcgccgacgagcggagcgggtcttacgacccgagtccaggaagacgtctcccagg
|
23881gagtccaggctgctctccaggggggcctgactccgagcagggatgggagtgaagtagaga
|
23941ctctccagggattctaccttggggggcRggcgctgggagataggtgaggctggttctcca
|
24001gggacgctggtgccgtctggctgggtacgaggcagcttgctatggaaaggaaacctgctg
|
24061aggtacagtccttcacgctagaaggcattttgtccagccctttttgaaagtgaccatttc
|
24121ccatccttactacaagcagatgaggtcaagcagcccatctctctgatttttcagaggtac
|
24181caaggaaagcacttgacctgggccttcctttcagtccactcccctggcttctcctaatag
|
24241ctcctcatagtggcaatgcccagacccagatgtcccatccccaccagatgcccatggctg
|
24301cttcacagcaaacacgtcccaatctaagcccacttctctgttcttcctcctgcatctccc
|
24361atttcagtgaataggaacgccccccactcaggcccccaagccatgaacgtgggcataatc
|
24421caatgtcgtcctgcttggcgagcccaatcaccaagcttcctgaacagcWMctaaccacac
|
24481cccactccatgctcatgtcctttccctggtctgcttcatctcctctcacctagactcatc
|
24541atggcactgacagaggaagatgagtggtgacaagccaagaactcaggccaggctgcccag
|
24601ggtcaaaccccagctctaccactggggaaccttgggcaagtgactgcccctctatgcccc
|
24661agattcatctgttaaaggagacagaataaacctacctcagagggttgttgggggacaaat
|
24721caggtataattgtcatgagtgctttatgtctagcacaaaataagtaaatgtaagtgttta
|
24781ataaaaacatttttccagtcttaacttctatactagctattagaataatctttttaagat
|
24841gcaaattaaccaYgtactcttcagtttcaaattcttccaaggttcctttttttttctcct
|
24901aaacctttcaattacagccaccaaggtttcctcaatgcctttaggatcaagtcttaatag
|
24961Ycggtctccaatgggccttcctggcctcacatctcagcttagtcaggctctttcacagcc
|
25021tctgttcacactgctcttctcgtcaacctggcacacacacctatggatgctttcaagact
|
25081cagcaggagcgatagcttccacgaagcctttcttgaccacttgctttttattccaactgt
|
25141gccctaaatagatatctggtataatacccgtttttcKttattcttctctaagaataaatt
|
25201tagatcacatcttatttatctcactaggatacagcctgataaacagcaggcactccataa
|
25261acagacatagggaggaaggctgcctcctgacctggtgatactgagtggggtcccctcctc
|
25321gcagctcagatccaggctgtcaatactcaagtccagctggggcttagcctggggctcacg
|
25381gctctttaaagcatcagttgccacctggaatttgcccaggtctcgaagctgctggtctgc
|
25441atgggcaacctgagaaggagagggccagggggagagtgaagaaaagcctaaggcagcagt
|
25501ggcctaggaggagagggcacaggggtccagtggaataggagtgaggtgagtctgccagcc
|
25561aaattcttacctgtgcctccaggctgcgcacctgggcagtaaggtggcggcaggtctgtt
|
25621cagcctccttggtcttcagcccagcctgctgtagctcatggcccagccgttcagcttcag
|
25681ctcgcagctctttgttttccttctgcagctgctccaggctccgcagctgctcctgcagct
|
25741cttggttctgctgcttcttggcatcataatgtgttttggctttctccatctgtgggcaga
|
25801gagggtgggtgggtggggtagaggttgaagggcaggaggaaggtggcatgggctggggct
|
25861gggctccttacctgcagcttatagtgctcagctgcctgctccttctggctcaactgggct
|
25921tgcagttcattcagctgggcctggaggcgctgggcctcctgctggctctcgcctccctga
|
25981gcctggacagcctgagaagaaaggccactcaggaaagctggtctggccgctctacccaag
|
26041tccgcttatctgcaccagccactggggctccacaggtgcttcagactcctgcactttctt
|
26101aggaagcggaagaaaaccacaccaccccaaatactctctgcccgactacagtctactaaa
|
26161cctgaagcccacaYgcccttcagtccacatccgtagtggcctttccctgaccagctcctg
|
26221ccctatctttgccttctttgagaccagacacaaagtgtcacaccctctttgcatgcacaa
|
26281tctcccgtaggaggaagggaaccaatcctcagggaacacccaggtgcagagccNtaSWSt
|
26341aaggcacttggcatgtgagctctcttaggacaggggaacttgtttctcctcaaagccact
|
26401ctgagaagtcacttcaccctcttttcagaggaggaaactgagttcagagatttaagcaaa
|
26461ttgaccagagtaacagtgactaaatggcagagtaagatttggtccacctaactccaaaag
|
26521cccatgggggcttatttatgatgcccacactgcctcctgtccagaccataactccttaag
|
26581agcagggcctgattctctgtccatctgcaaggccaacaagtgctttgctgtagatagaag
|
26641catcccccctttgcctctcctaacataggacaggccccacaaggagtagaataaacattt
|
26701gtttattgcaatcaagacatgctgtggcaccatggtatgaaggtgagcaggagaaatgaa
|
26761gctctgagctcccaacaactcctaggagccaccagggctttagtgagtcccaatgccact
|
26821ggtgcccaattcctttgcccctgactgaaggctgtgaagcctagaactgcaaaaagcaag
|
26881tattaaaccaaagaaggtgacacagttgaaagcattaagaatgttattaaactgcactgt
|
26941aatattcaacactggtgacactctYgttctttccctgcccagactatctagacttacatt
|
27001gtccaaaagaactttatgcaatggtggaatgttctgtatctgcgctgtccaatacagcag
|
27061ccactaaccacatgtagctactgaacaggggcacagtgtagctagtgtgattgaagaact
|
27121ggatttactttaataaatttcaataaccacacgtgactagtagctgctgaagtggacagt
|
27181gacagttgagagatgggaaccaccctggttgtctctcgagagctcccagaagacacatgc
|
27241aggggcttctaagccacaggcttcctaggagggctacStggaatgcagggtgcccctctt
|
27301ctgccccgacaccccccacggccccagagcttagagaatagcttccctcccttgtccaga
|
27361ggccagacccattcccccagctgccccaccttcagcttctgctgctgcaccttgctggct
|
27421tggtcagagtcagccagtttcttactcagttcttccacctggggagggaagaggaggaca
|
27481gaagactcaggaggacttcccctggatgttcatcctggatgtccacccatcatggggttt
|
27541cccagaccaggatccccagtgttcctagaataaactcaggccctttctctggcctccaat
|
27601tacggaacagcctgctgcccaggctgcttggcagggcctgaatgaggcaacctaacacat
|
27661agatgttgccagggccaactgttcttgcgtctaccctgagcctgcagagacagaggcctg
|
27721cccaacccccgtcacctccaaaatcaggagaattgactctggggagccgacacctcacca
|
27781ccaccttgctgccgccacactctgcagccgcaaccttcccaggacctagtctgtaattct
|
27841agtagacatactcaatgaattcccatgcctccctcccagaaactgccaaagcccaagccc
|
27901acagatgctcagacctcttcccaacatccacaggccgttagggctggtgctagcagcatg
|
27961gctgctgtggttagcattggggaacagattgctggaagacaagagcaggggcagcacatg
|
28021tactccaaagcccaccccactYctacaaagaggaagagcacagggagtaggggaaaagag
|
28081agaacataacagccccatgcacccttggctgctccaagcattctgggagttcaagcatga
|
28141ccaggcagcacaggggagaggcaagggctccattgctaactgtttgctattcactttgat
|
28201tgtcccccactatcacaggctccttagaggagggcccaatttttcagcagccctggggtg
|
28261gctgggtaggagagtgatggagaaagggtgctctatagcctcgatgtctcagaaacacca
|
28321gctctatagcctcgatgtctcaggcaacacagagatgattcccatgagaaagaggcagcc
|
28381agaccatgtgacccccactcccccgcccccatctggtatagacccctcctgctccttcac
|
28441cctcggtcttcctgctacagacatctctatgctgtgctcggggttagagccccagaaagt
|
28501gatgggcaagtgtcctaagMccacaatcctccMtaacctgtgggggctgcctcgcatatc
|
28561accttcaaggcttccataaagctgtactctgggaaaaagggacaccatgttaaacaaggc
|
28621cgacacggtaattctgctgttcctcttagtcgggtatccttaactagacacagtacttgg
|
28681gaagttctcgaatcccaaggattgtgtctgtcattggttcagggtgggaaagatgaagcc
|
28741agtgctaccccttgtccctgataRgcaaatgagagaaggtgcagaagggtggagaggccg
|
28801acctgggatgggtgggatgaggcctgagagagcccagcacaccacactcctgggcagcct
|
28861gggcctggattccatggcttgaccctgcccccttcacaaacagttcacaacaggagctgg
|
28921cggaggcaagctgcagccgggctcatgcaccaagactggtcaccgtttaagcagccagca
|
28981tttagcgaggacctcaggcattacctgcttagtttgctctctctgaaatacctctagctg
|
29041ctccacctgtacatgggggaggagcaacagagacagagtgagatgaggccaaagaagcac
|
29101cagccctgctgccaggctgacctcactgaggctctgatactttcccctaaggagctagat
|
29161tgacagtaagtttaaaaatgccagttaggctgattctaatccccagtggctcctgaggca
|
29221tccagtgcaggtgtgcctctgaacaggctggtggtcatcacaacttgactctctagtgac
|
29281agagccttcaggggaggggaggccactgacattttctttaggatgacaggggcaacagac
|
29341ttgaactccaccagccacctctccttttctgccacccagtgaatgaggaaaggcaagaca
|
29401ctccagtgtaggagctagaggccctggacacagaggatcgatgtccccgcgctctcagct
|
29461cctgatctttgggagggtggttgggctgagtaccttacctgggcagtgagtttctgcctc
|
29521tcttcctggaaccgctgcctctcctccaggaccttgaccttggcaccctcatacttggca
|
29581gtcatcacctccagctcccgggcagtgctctgtgcttctcgctgcacctcagccagacgg
|
29641gtctcagcatcagcacgtacggctgccaactcttggacatacttYtcccgggcctggtcc
|
29701aactccacttccagaaactgccggccaaggttggcccgctcacccagcccccggttctcc
|
29761tctgccagcaggccatgcgccttcttcagcatgctcagctgctctgcatagctggccttc
|
29821tctgcccgcagctgctgagctgttcgctcctgctctgccaccttctgccgcagaggaatc
|
29881agctccccaagctcccgctgggcccgcagcagctctgcccgcagtcccccagcggcctgc
|
29941ttgctctgctccagctcctcacggtggcgtttctcggcagcggcctgctcggcctgcagc
|
30001tgctggcagaggtgcttagctggcagcagctcactcaccagggcctgtgtgctggtgtgc
|
30061tcgagctgcagggtggagagggcctgctctttctggaagaacttctcctgccacgccttc
|
30121aattcttggcccagctcctccgcacgctcagcctgtgaggtcagctcctgccgcaggttc
|
30181tctgaagccacccgctgtttctcagcctcctcccggaggctctgcacctcctcccgcaga
|
30241gcagagctgcgttctgcagctctggcactgttgctggctgtctctgcctgcagcaggcgc
|
30301agcctctcctccagcttctggctcttctctgactcggccatcaccagccgcttcaactcc
|
30361ttgctctccccctccttctccaggacctggcgattcaggatggacacctcctcctccaag
|
30421ctgctgatgaggctatttttcctctcagcctcttgccggccccgggccacctgggccttc
|
30481cactcatcttcagccttgctgtggtcttgtaccttggtgcggaaggcagccaactcccgt
|
30541tgggccgaggctaaggcactctgactgtgccctagctcctgggccttctcctctaactgg
|
30601ccctgcagagtctccagagcactgtcccgctcagcccgggaggcccgctcagcctcgagg
|
30661ctgcgttccaggctgtcagcctgctcctgctgcttctggcattgctgttccagcttgctc
|
30721acctctgcccgcagtgcYtccagcttggggcctgttggctctgtcctgccagcagcctca
|
30781gattgggctcctgagccagatgcgtgctccttttctttcttagccagctgttccttcagt
|
30841tgcttcacggtttgccgaagttcctccagctcttttatctgggctgcctccagaccacga
|
30901agcttggccaactcctggtccttgccttccttttccgtcagggcatgagccagtgcctct
|
30961tgcagggtagcgaactccacacgctgctcgttgagggcgttctgcagccgcatctcaagc
|
31021tctgctctggccgccttctccagggcaaggtcagcctgggcacggccccgctcctgggtc
|
31081agccgcgccacctccctttcctgctgcccacgctcctcctgctgctgcccctggctctcc
|
31141atcagcgcggcccgcagccgttccagctcattgcYcatctgctctgcctcccgctccata
|
31201gcctgcagcgctgcctgtgtgctgcagaactggcgtccctgttgctcttccagccactcg
|
31261ggctgtctgtctcctgccctcgcaggctccttgactaactcccgggaggctgtttcctgc
|
31321tgctcacctgccttgcgcaccaaggtctccaagcgggccacctctttgctggtggcagcc
|
31381atcttttcctgcagagtggagaggtcatctgcaagcttctgggccctgacttccttctct
|
31441tggacctgctggagtgctctggccaggttggcatggagctcagctagttYgttctgctgc
|
31501cggcttatctggagctcgctgtgggattctatgcctgccaccttctcctttgcctcctgc
|
31561agctcctggcgggccttctcacattcctccttcaaagtcatcagctgttcctggaacatg
|
31621gcgccatactgtgcctcctcttgctggctatcctcataccgctcacgccaggcagctact
|
31681tctttgacgagctgctcacactcactctcagctgtgtgctgggcaSccatggcctctgcc
|
31741agctcccgccgcaggacttcagtctcagcYtgatgggcctccccaagctgcWgtaatcga
|
31801gcctccagccccttgcgcccagccctctcttcttccagctcctttcgttcccgcttatgc
|
31861tgctccaccaggcttcgggtctctgccttcagctcagagatacaacgctgctgctcttcc
|
31921agggcatctgcagccctgcgcttctcctcttcaaggctgcccttggtgaccttcaaggac
|
31981tctttgagggcctggagctgctcctggagctggtccttctcctgggccaccctttctttc
|
32041tcagttgctttttgctgctcagaccgcagctgcaactctagctctgcaacctgggcctgg
|
32101gcctcatgctgttcctggcgggctgtctcaacacaggcctggagttcctccaccttccgg
|
32161ctcagctctgccttctcccgctgggcctgtgtcactgaggtctgggcactgtcccgggct
|
32221tcattagccacctgaagttgctgctgcagaatctccagcttggcagccttctccttctcc
|
32281agtgcctccagctgcttgagagccgcatcccgctcccttaaggaggcctctcgctcctct
|
32341gcagcagtggccagttgctgggcatggtcctgcctagttgcctcctgcttctccgctacc
|
32401tccttcaactgctgctccttctgcttcaggctactgcttagctgctccacctggtggcgg
|
32461aggccctgggaggcctgttcttgctgttggagggtctgtgctagctgggcctgcttctct
|
32521ttggcctgctgcttcaggccagccagttcttgatcctgttgctggatggtggcattgagt
|
32581gtggtgagctcagaggtcagagaggccacctgggcagtcaaccgggccccatgagcctgg
|
32641gaggcctgctccagctcttccttggcctggctgaggttggagatggagctctgcaggtca
|
32701gtgatcaggctagacagctgctgcttttcttcttcgaagtggccccgctcagcaagcagc
|
32761ttggcttcctgctggcctcgctcagtctccagcatctctaccctggcttggagctgtgtg
|
32821ttgtttgcagcaagagtggctgcctcttgcttcaaggtttccagctggtggtataaagag
|
32881acaaactgggatcagcatgactcctcagtcatcaagactcctctggaaatggaggaacac
|
32941caggaacccaaatgtactgaatgtgagtccacaccaaccMgcagcacacaggtctttctg
|
33001tgcattcctacctgcaagacatcacccagcacctcgcccttctcctggggtgggttatcc
|
33061tgcagctgggacaagtgttcttccagctgtgaaagttttccctgaaggatttcgttcttc
|
33121tcttcaaggcatttctgggagtaaatgagacccatgtgaacagagagggggaacaggcac
|
33181cagattaccacacaagccctcataaacatcagcaaacatggggcccatcatcttgttacc
|
33241aagatctccttttgccctggcctagaaaaaagcagaaaccatggaactgggagcatgagg
|
33301gacctgattctctagacctagttctaaggcacaataaagtcataatgtaacctgcttact
|
33361acttccccaaggctgctgagtttacttcaaatttcctYaccgtatacccttcctcagata
|
33421agtcttgagtcctagattatccaaatcaccaccagctgcccaccatcctctgggcagcaa
|
33481taccactggcagcagctgcagcaacccccagtcccaaacccacttcttcaccactgttca
|
33541ctaagcacctacaataggctatgctgggttcatccctaaWtttttttttttttttttttt
|
33601ttttgagacagagtctcgctctatcgcctaggctggagtgcagtggcgagatcttggctt
|
33661actgcaacctccacctcccagattcgagagcttcttctgtctcagcctcccgagtagctg
|
33721ggactacaggcatgcatcaccacacccagcttatgtgggaggcagctactaccattcctc
|
33781ttacagagcaagaacctgaagcagatgctaagtgccttgatcaagggctacatggttatt
|
33841agtaagtggccaaattgggttcttaccaatagtaacaatcacaactggttcactgagagc
|
33901ttactttacactacacgatgtgtgaagtgctttacatacgttttctcataataggtgatg
|
33961aggcagctactcgttactactcccattttagggaaaggatgcttagaaaaacagactgat
|
34021taacttgtccaagatccacatcttgtgaacagcagagataggattgaaaggtgtactata
|
34081aagtgagggcattgactggggaaaaaaaaaataagttaaaaaaaaaaggtgtactagact
|
34141gaagcccacaatctttcaattacagcacactattgaaccttgaagagaaagcaacttaat
|
34201acccaaaggcccagaagagcacagtggtaaactggactcagctttgcacatgtggtcaag
|
34261actgtggctgtgaccccagcagagggttaccttgtcctgcagggctgcgctgagctcctt
|
34321ctccagctgggcctgcttctctagccactcctgagtggccttgctgtgctcctccgtcag
|
34381ctcattgagggcatcctgtagctgctgcagatgactggcaaactcccgcagctgagacgg
|
34441gcaagtgagaatccccatcacccagaNNNNNNgctgaccccaccactgctgtctgctccc
|
34501agaaccccaggggctggatgcctccaattatcctgccaaccctctacaaaccaatcacag
|
34561ccatcacacctctaattcagaactacaaatcaacatttagggtcacagcccagtacccgg
|
34621gaagccgccaattatgggataaggaaaggggcaaaatatgcaggtctctggagagactga
|
34681agcataagacaggtgctgggacattcttctcaaccctctcttggggagccttccagacca
|
34741cctcagccctgaggggcctccatgcacacaccaccttaacacccaccttaaaggaaaggt
|
34801ctccattctcctccgaaagctggttgattttgcgatccatctggctcttctctgtcttca
|
34861ggtcctggcactgcttcagggtttcatgcagccgcatggtaaggctgcgagggagggaag
|
34921cagtgagaagagagtatgggYtcctggctgggtgaggggaggggctggggcctgggaagg
|
34981aatgcagggagagctgtacctctcattcttgtcacgcagctcctcaagctccttgggctc
|
35041cagtgggctggccgcctgcttctcattcagcagggctaggcggtcaatgcgctgctgcat
|
35101catggctatctgtgcatctgcccagagtggagggaggaggagaggagaatcagaactatg
|
35161tgcatgagcggaactatgtgcacagaactatgtgcacaaggggaagggaggagRcggcat
|
35221agggaagaggaggaatatggtatccaatctaagggaaagagaagatggggacaaagacag
|
35281aacctagcttccaggaggtcagcctgaccacaggcccagggctgagctctcagctccagg
|
35341ggccagcagaggggacaacatgggaggccaggggacatccttccggcaagtctattcaca
|
35401catctgccagtgtgccagccacctacccttctcggtgaggagcttgcggttctcagctag
|
35461ctccagctccagctcatccctattacttctctcatcagcaagctgcttcttcagccgtct
|
35521catctggaactgtggggtctgcaggatatcacccatgggagaagctggagaacctgagag
|
35581aaagctgaggagggagaaggcccatatgcattggtaagcgcctaagatStgaagcaatca
|
35641gcaacaggcagcagtaagggagcggggtctatggaagtgcgcactagcagctgggaggcc
|
35701tgtgcacctgggttgtttgcagtgctacctcaagcctcatgacatgatcttgggaaaact
|
35761tttcttctcactgccttaatttctttgtcagaaaaaaaaaaagtgatatattctccttgg
|
35821ctctgcagagatgtgctaagagaagagacttcattgtagtctcYgaggaagaagggtatt
|
35881ccataaacagggaacagcttttgagggaggccttctgcacatgacaaatcccaaccactt
|
35941cccccagttaatactgggtgaggtgaggagatcccagatctaccggatactctaagcact
|
36001cccagaggctggttaacatcttaactctagaagttaggaatgtgaggaatggatggatgc
|
36061tgaggccctatcccaggaggagaggcccagaacatacttgttcccactggaagaggaggc
|
36121aaccttctgtagctctaggaagcgaatctccctcttggcctggtggctaggtggggagag
|
36181ctcttcagggaatgtgctagaacaggtagaaggcacaggagctgggggtaagaaatagac
|
36241aaaataaatcaacaaaggttagtaagaaggtgWaaagatttgcacctttatgcaatttga
|
36301gaactcgccttagtgggagtatatccatggatacttatatgtaaactaccaaggaaggca
|
36361ctgggcagaacctgaaacctggtgcctgggttatccagagttccgtgtctctaaccaaaa
|
36421tgaagtgcagggcttccatttctacagagcatcattactcagagcacagtggagtgacgg
|
36481tgtcctctggctcagaaactgcaccaagtgctcaagctttttcctcgagtccacactgca
|
36541gagacggcttggggagccctgagcaggatctccttgcagcccccaacaacctttcctatc
|
36601agagccattggccaccatttggaattcatcccccctgaagccttgcacctccaaaatgcc
|
36661ctcctcctcaaaacccttctctttccgtggtttccgtgaccccttttgtaggactctcct
|
36721acctctaatcacccattcttaagtctcctcatctgctcctccctcctctacccaccctct
|
36781aagctcccagagatctgatggggcctcttggctctgcccatagtgcccacggcttcagtg
|
36841gccatccaatgctgacttgcaaacctatcttctggtccagagcctgctcctgaattctgg
|
36901actcacatttctaacatctccacctgaaggtctcatgaggaacctgaatacaaggaacat
|
36961caaactcaacggctagaactcgcctagacctccttcttacattcctatcatccaccagct
|
37021gacctcttcatcagaagaccagcagaacgatcactctttctactgtagtaccagccgagg
|
37081ccattgatatattccgtacttagattccttatcattatttcctggtttatgtatctgcct
|
37141ttccacctagaacatgcactacatgacgggaaaaacattttttaaaagactgtgggccgg
|
37201gcgcagtggctcatgcctgtattcctaacactttgggaggccgaggcaggtggatcacct
|
37261gatgtcaggagttcgagaccRgcctaatcaacatggtgaaaccccgtctctacaaaaaat
|
37321acaaaaattagccaggtgtggtggcatgcgcctgtaatcccagctactcgggaggctRag
|
37381caggagaattgcttgaacacgggaagtggagattgcagtgagctgagatcgcaccactac
|
37441actccagcctgggcgacagagagagactctgtctcaaaaaaaaataaaaataaaaataaa
|
37501aagactgtattctcagcttctaagcctagagtaatgattgtttaaaaaataaaaaacaaa
|
37561agtaggtatgatcacttgtaaatatcctacataactgctgccaggcagcaaggaggagct
|
37621ccataggaactgagatgatacaacatggcccagaaatcgacctactccattacacacact
|
37681tttcctgagcatcaactctgccttgtgttggggacagaaacaaacccccaccatacttga
|
37741caactcaggatcctagtattccccatttcagagatgaggggattctcaggagtgtgtacc
|
37801tacttacctttctgtaggaagttctctaggtcctcattaaggtttagcccgtcctcatgg
|
37861tccagcacaaatttaagaatgacagccaactcagcctgggccacagggagaaaaagagca
|
37921tcacttaggtgttaggcctctgaagggatggctgccaggagctccaccctggcagtgcca
|
37981gtccccggctccctcatgccctaggagcctgctggatcccattctccctctcagagctga
|
38041ggtcctatgacccagccaacaacattcaactagagatatgttcaccccacttgtcccctt
|
38101ccctcccacctcccctcaagatgtaccgaagtcagagttcctgactgacttaactcctga
|
38161ccacaagtgaagtgactgttaaggaaagtaacacaatcagaaagttgcttttattgttat
|
38221tgttgttaagaaacaagatcttgctctgtcacccaggctggagtacagtggcacaatcat
|
38281agctcactataacctccaactcctggagtcaactcctcctcctcagctccccaagtagct
|
38341agaactaSagacacacactgccacacccagctcattttttttaaaaaaaatattttttgt
|
38401tgagacagggtctcgctatgttacccaggctgatcttgaactcctggcctcaagcaatcc
|
38461tcctgtctcggcctcccaaagtgctgggactataggcgtgagccaccacgcccggccagg
|
38521aagcttttatatataactatgttggcctcttccagatgaccctaccagaggaaaggatga
|
38581gataaatgaagtgaaagttctgtggggRaaaaaaaacacacacacaNNgaaacacatata
|
38641ggaacagagaataatttctacgtattatcctaaaacacattacagttaaacatatgcaca
|
38701taaaaaaggacttgaaagtacatcctttaaaaagttagcaaactctgggaatgagtttat
|
38761cggcaactgttatttcctcctgcatgcttttcaacgtttcccagactttctatgatgaat
|
38821ggcaataattgctataactgtatttttaaaaagtccagtatctgctgttcaaagaaaaac
|
38881aagtcaggtgaggtgaagcatgggctaggcctgctaggtggcatggaggcacaagggctt
|
38941acctgaattttatattcaaactgttcccagtccctgggacttttggagctcatggtagag
|
39001tggtataagagcagcatggtcatctagaagccaaacaggaggcagtcaMtgagtggggct
|
39061gtctctcttctcagtgYccccattctgggctgttctggggactctgagctattccggtga
|
39121ctcttctaaaagtcctggaattcagcaatcccaggccaccatccttaacagctccaggaa
|
39181acactttttttttttttttttaattaaggatagtgtacactgtacaaaaagctgagcgcc
|
39241aagattcctgcatggctcaattcctggactcatggaaccctgggtgtgaagctttaggta
|
39301ccctctataggccagcacccagaaagagcagagggaatgacttaagactgagctataata
|
39361aaaatatggtgatagccgaatgagacctgatttctgccaggtctccaccgaggcccacag
|
39421taatggtctagtaaaccattgtttgtttcataatctctgtcataagatcatgggctccta
|
39481gaatccttgggctaaattagcctctgtctcaagacaggtggctgcctggttctacctcca
|
39541acgtactagagccccagaaataaagcacccatcatctccccttgggttaagagaaggccc
|
39601tgcagggtccctcaggtaccatcaccccaaccctgccctgcctccccagtctggtattcc
|
39661ataggtaccttcgccagttccagctctgatccctctagcaccttctgtgcagataccagg
|
39721cattctggggaagagggatgttttcgattttctgcaatgacaacaacgYagaaaacaggg
|
39781tgaacttcctggaaaccatacctgagatcccagaacactgaaatctggggagcagaatgg
|
39841ctatctctggtggggctatgagatgtaggcctccttactcctatggcctctttcccctgc
|
39901cttacaattttccatctgaagtcagttctatcctgggtcaatccaagggctacagggata
|
39961atggaagaagaaagcagcctcggaattcacagcaactctgggtcatgatgttgcactctc
|
40021ccacccactcaccaactctcagcaccacagaggaagagcccagagatgccaggtcacttt
|
40081agaatcctgttccaactgaggtcacagagtaaacctatagctgagtcagaaaaggacaac
|
40141tagggatacgtgactcttatactgcccgagggtctgggctcaaattactaacaccttact
|
40201ttatctaaataaagcctcacctttcctataattctctaggggtggagatggcagctagct
|
40261ccccatgtcaaagacgaggactctgtggtctaaggctggacaaggggaggggaactgaaa
|
40321agcactgtactagaagctttgcatgtgttcttatttaatccacccatccacttgaagagc
|
40381agttatctccatattatagatagggaacctatgtccagaaaggtcacacaagcagtgagg
|
40441ggggtcaagatcaaccttaatgtgcctctgcccctacacctatcgcctaagcaattaatt
|
40501caaagttatctgggaaaaacagtttttcttgcaagggaaagagactcattctctNttctg
|
40561tctccttgaagttcggggaaacagaaacttaaggtgctcaaagagttaaaagtgacaggt
|
40621cccaaaaagtaaccttctggctccacctagatctccgagaagggctctgggactgaaggg
|
40681acactcttcttacaccaactgatgaaggcatcacaagacccaggggatctgaaccagctg
|
40741ttttcatctttgtgttaaagagtggggagccttgaaatttttctcctccagacacccatg
|
40801aactagttcctctggactctccaatcccacgagctgaggaagcagcttcttcatagctgg
|
40861ataagaaaggtgcttactctgcagaaaactgcacacaaagtccagtctctctgacaccgg
|
40921ctgcttcaagatttgctgtccctcttcagtgccatggctagaaaaagagcaagtattagg
|
40981accagagtattcagcaatctttgcctccttgctgctgcatttcatagtacctccccattc
|
41041cttccagtcttgatctctgctggatctggaagagatccagatcagatcctggaggcaggt
|
41101gacagataccaggacaccatttatccagatggaactgtgtggtgggtgggaagaggggac
|
41161ttgaggcatggggttcttctggaaaagatggcactctgccaccctatttgcaaacataaa
|
41221aaagctctgtggaaaggggccgagaggagaYggaggcagcacagatgaaYgggaagctat
|
41281attacaccatctggaatggctcaactctaaactgtcaggaagcctggagaacacacctag
|
41341gttaagagtgagagaagaccatggggagggaaaaacatccaagaactgaaagaacaggag
|
41401gaaacaaggctctgaagtgacagggtgaagttcccccactaggctgaaggctgagatggc
|
41461aaaagcctcccagaggaggatcccagggactagagtgttgtttgtttgtttgtttgtttg
|
41521agacagaatctcgctctgttgcccaggctggagtgcagtggcacgatctcggctcactat
|
41581aacctctgactcctgggttcaagcaatcctcctgcctcagcctcccaagtagctgggatt
|
41641acaggcatggaccaccacgcccggctaatttttgtatttttagtagagatggggtttcgc
|
41701catgttggccaggctggtctcaaactcctgacctccacccacctcagcctctcaaagtgc
|
41761tgggattacaggctggagccactgcgcccagctaggactagtattcttgattagtggttc
|
41821ttgtctgtacttgcttaactggaagagcgggcagtgtgaagagagccatgaggagaggga
|
41881gacagcagggggagctctcacacagcccaggaggctgaggcaggagaactgcttcaaccc
|
41941aagcgacagagattacagtgagctgagatcatgccactgcactccagcctgggcaacaga
|
42001gcgagattctgtctccaaaaaaaaaaaagaatactagtccctgggatcctgctctgggag
|
42061gcYtttgccatctcagccttcaacctagtgggggaacttcgctggatcccctagctaact
|
42121gcagttccattttcagaagcagcaggtgaaataccacttcaagttagaaagctgaattct
|
42181ctaggctacagtgggagatcctgattagtgggccccttgcttctcagaatctacactcct
|
42241agttcttagccaactttctggagggcagggcaggcccagaaccttccaatgccagagaca
|
42301tcctgcaagcataagcatcatccaagccaagactatgagtgtacctccccccatacccca
|
42361tgtgattacacaggcttcttccaagtgaatccctcccagaagcactctgtctggatagtt
|
42421ggtctgagatcagagactcctacaaagtcttgaggagatgctaatctcttacagactccc
|
42481aaatgagccattttccctacccacccacaatctggaatgttgtgactccttggctcagtg
|
42541tagagcaatatttacctcagagtattccattaaYtaaaataaaaagaggttctcaggtga
|
42601aatgtttaaaaaatgctgggttaaactgaacattttttatagaagaagatacaacatgca
|
42661ttatttcctaaacctatttgaccacaaaacccttttcccccaccccctacaaagcctggt
|
42721gtaagtaaagctgcatggagcatactttggacaacagtagtcctagagaaatccagccca
|
42781tcctttaagactgtgttgaagtctcatctctgtcaggaagccatccacaactcctgccag
|
42841tcatgcctcggctgtcctccaggtcttcctgcagcactcatgaatgcaactgcaccattt
|
42901acaactgcccaYtccaactgcactagctgaaagccaggaataaagtaggtgctcaataca
|
42961tatgggctgactgacaactgagggatgctttttactgagaagagcagaaataaaagtcag
|
43021caagacaaaaatgtcagaMctStaagttttctggcaaaatgcctccactatactctgtta
|
43081ttcaagcttcacagctatcaaacagacgggacagccttttttgctttagactattcacgc
|
43141acagaagaaccaaaagggaaacttgtcagaggggttgatcccagttaattttcccagaga
|
43201gaaggccaagtggccaagcaRttaaaccctcaactcccacagcttattttttttttaatt
|
43261ttttaaagaattatttttctcagggtgccccttgtccagtgtgcagacaggagccaccca
|
43321actcccacagcttctatctaccctccaaccttgccatcctctgctgccttctgctgagaa
|
43381ctaggctgctgatttaggttggcaccagtagcggtatcagaaatgtaagagccagaacat
|
43441attaactaagaacctccatttcccaaaaggaagctggtctgcattgtcctggatctgaga
|
43501tggagattagcattaacYtgggatttcaatatcgcctacctccaagccccacttctactg
|
43561cagcctaggttcaggcaacaccctagaagacaacttgcaaatgagcatcttgaatttttg
|
43621gcccttcctatgaaaatttcctaScaggttataaacctacagtggctaacccaaggacaa
|
43681cacacatccttactcttgggcacatctactgctcttgtcaccaggccaaggaaatttctc
|
43741tcttcaaaagcaaaagttccttgatctattttgaagtcaaaaaagcatgctgccccatat
|
43801tgtgtgttacaatacaaggcatattatacctggctgcttcacttttagtgaggttaaaat
|
43861taaacagagagttaggtattgccagactaatggttttaccacccattaatgtcaggtgcc
|
43921tggatctatcacttccttagggtttgcaaaataatgattttcaacagaagttgcaaaatg
|
43981ctgacttacaggtggtacacaaccccaactatgaagtatccttgacaaaaaaaaaaagtg
|
44041aatcaagcttagatctaattatcagtatataggcaacaaggggaatagtggaacaagtta
|
44101agccgtaccataataatgcaattaacaaaatccaggatttaaggatttctataagattaa
|
44161aaaaaaatgaggtggtgtcgagtggggagagaaaaaagcaggaaacaaaactggtgagag
|
44221gaaatgaccccctgatgaaagatcttaaacaccaggctgaagattttagatttctaccta
|
44281ttagaaatgaatattcactgaggtttgatgaagagtcactgaagtgtcacaaagaaaaca
|
44341agatttgagaaagattcttgagaactcgtgcataggaatgaactgcaataagggcagatt
|
44401agagaagaactaggccatgagggcctagtatccagaatgaggcagagggagggacgctgg
|
44461atgtgagcagagaggatgatgaccaattagagatcagcgccaaggagacagagaagtcaa
|
44521gatgatgttgaaatgtcctgcctgggtaactgggagagaaaatggtactgtctggaccaa
|
44581aataagaatagtgacttctttcagaggtactaaggcaggtcctggttagagccatatgga
|
44641atattaaaaaatcctgtaagataacccacgatcaacacacacttcaaataaaaaccactt
|
44701tagcagcagacccatctgtcctgggccacttggccccgctagaccttgctgatagagaac
|
44761accaactcatctcttcactcaacaaacattcactaaaacctaaacaatgtagcatcctaa
|
44821gctaggtagggaggaccccaagatgaatcagacacagttctagcctttgataagcttaat
|
44881tctaccttctttccctatcaatgagctgttacctatgaacaggtagctaaagtgcttgct
|
44941tcagagatatgagtccctgataccagttcctaactgccacRtatggcacataaacacctt
|
45001caacacttcagtYtatccttggcctggggcaaacaatYtaatgtgctttttcttaaaaaa
|
45061aaaaaaaaaaaaaaaaaaaaaagatgacaactgacctatgcttggtcccagaaaggtagg
|
45121atactgggaggaagccccactttattcatttccgagataactgtgacgttcaaaggaaat
|
45181gtgctaaagacacagaccaaaaggccaaactacaatccttgctgcatggtaacaacaagc
|
45241ttattaaatgctcatggacctcagaaatcaagttaattgaagcagtaaaaaccccagaag
|
45301tgtacttattttataatggcttagaaagaggcatatctgtactgtgctaacaagttagag
|
45361atgagatttctaggtgtttcttctttccttcagatgtgagagcttcccctttcttccctc
|
45421agaaggctgcaaagagggcttgtggcatagggtagggatgagtcaagaaaggagggttgt
|
45481agaagccttctggtgagacaagagatggggaacccaagagtgagcacttggaagaatgtg
|
45541agggcgtggagccttggaggttctcctgtgcaagaatgcagaagcctcaggatgggacaa
|
45601gcgtaaaacctctcccatggagtggtacagcaactggaagatgaggtcaatgtattcttg
|
45661cctttaggccccaccctggcttatgatgtcccaatccttcccctgatttctggtcatagc
|
45721catcatcaagtaaagagaacaagtacagcccccaccccagcaatcagctttgccttagag
|
45781gctagaaaggggtatggtgcgtactcacattctgtcaatgatcttgatgaagatgctgca
|
45841gtcctggagctgcagcacagcctccacagggtcagccacgtgtagactgttcacctgtaa
|
45901atcaaagggaacagcctagtgagaccgttagaagcaacatggtttgctccttttcccaga
|
45961ggcttaatgtgagtgcttacagttgtagactataggaatacaagaactgatgattctcag
|
46021gtttttaatttcaggaaggagtgccgttgcactcactcatccagttacagccacctgaWa
|
46081tgcaaccatcagagagcccttcctttggcttcaactaaataaaagcttaaactttcctaa
|
46141gatgttccagcactgggagtattttggaaggatacaccaataaattggtactaccactgc
|
46201ttctaaagagaggaacttgacagcagggagtctgaggtgggaaaagaaaggctcttacat
|
46261tataactctctgtagctcttgaatgtattatagctctttgtatttcttgaacgtttacat
|
46321tataagtttctgtatcccttggatttttatattatagtcctttgtggctcttgagttttg
|
46381aaatatctattcaaaacttaaatattacatatatgctatacactcccacaaacatataaa
|
46441atcttattaatacattttatattatagccctttgtggctcttgagttttgaaatatctat
|
46501tcaaaacttaaatattacatatatgctatacactcccacaaagatataaaatcttattaa
|
46561tacatttttattctttccacacataaagctttggctgaggggagaagggaaaaacaatag
|
46621gggaacaagatgattttttaaaaagggggtggagggagccaagcgcggtggctcacacct
|
46681gtaatcctagcactttgggaggctgaggcgggaagatcacttgagctcaggagttcaaga
|
46741ccaacctgggcaacatggtgaaaccctgtcctacaaaaaatacaaaaaattagccaggag
|
46801tggtggcacatacctgtagtcccagctacttagaaggctgaggtgggaggatcaccttag
|
46861cccagggaggtcgaggctgcagtgagctgggattgcatcactgtactctagcctgagtga
|
46921cagagcaagaccctgtctccaaaggaaaaaaaaaaagaaaagaaaagaaaaaaaaagggg
|
46981gcggtgggggatgaaagaataggagctgggaatttcaaagaaaaacttcttaattctaat
|
47041ttagttgcctgttcccattctttggcttcagataggcatacatttaaatcagtttttacc
|
47101actagaatattcaccaggggtcacacacatcaggtacacaggttattcaataagtataca
|
47161tggtcaacctctacaggaaaacctcatgaattccacaggcactacagttcagaagtagcc
|
47221tgggctgaagtttacgtttttattactataggaagaaagggtttgctaagttaattattc
|
47281acatattcaacactaagaggggagagagactgagcctgctttaagaaacaaggtatttta
|
47341aagaacttcagcatagtggttatgtgcagacaactagattctattgcttacaaatgtgtt
|
47401ctctatatttgggctgggagccagtacatacacactttgggcccagctcctccacaaact
|
47461tgccagcaacctttgttacaaactttatttctctctgcactagtttcctcccttgccaaa
|
47521tggatggaatccctactttatctacttcaaaggaccagtgtgagctcaaatgggattatg
|
47581gatgcaagaacacattaaaaaatataaagtaggccaggtgcagtggctcacacctgtaat
|
47641cccagcactttgggaggctgaggtagggggactgcttgaggctgggagtttaggaccacc
|
47701ctgggcaacataacaataccttgtctctactaaataaataaataagcaagcaagcaagct
|
47761ggacatggtgacatgtgcctgtaagtcctacctacataagaggctgaggtaggtggatca
|
47821tttgagcccaggagctggagaagttacMatgagctatgatagtgtccctgcactgtggcc
|
47881tgggcaacagagacatctcaaaaaaaaaaagaaaaaagaaaaactaataaacataaagca
|
47941ctattatggttaataaaattaaaataatgaagtagacataacatttgtatttcttaatag
|
48001ttaagttagctgcatgcactatagaattaagaggatttttaaaaatcaatgatttctcta
|
48061cagacatgatagtatttatttgagttaaaYactttcacatttaaaaacaacttttaggcc
|
48121aggcgcagtggcccatgcctgtaatcMcagcacttggggaggctgaggtggaaggactgc
|
48181ttgaggccaggagttcaagaccagcctgggcaacataaggagaccctggctctacaaaat
|
48241aataatttaaaaaaatttttagctgggtgaggtggcttgcgcctgtatgctcRcgtagtc
|
48301cctgctactcgggaggctgacgtgggaagatcgcttgagcctgggaggtcaaggctacag
|
48361cgagctatgatcacaccactgcactctagcctggccaacggattgagaccctgtctcaaa
|
48421aaaataaataaataaataaatacaacatttaggctaggtgtggtggctcatgcctgtaat
|
48481cccagtgctttgggaggacgaggagggagaatcgcttgaggccaggagtttgagatcagc
|
48541ctaggcaacatagcaagaccctttccccaaaaaattaaaaaaaaaaaaaaaaagagagag
|
48601aaaggaaaaatagcccagcatggtggtgcatgcctgtggtcctagctactcaggaggcta
|
48661aggtgggaggcagaggattgcttgagtgcaggagttccaggctgctgtgagctatgaagc
|
48721tgcaactgcattccagcctgggtcacagagcaagaccctatctcaaaaagMggaatcttt
|
48781tagatgaatcccagttaaaacagattaaaattttttttaacgtgaaataaaatatgactt
|
48841attgacgtcttaaagagtttgctaatatatttataatatatttttactgtcttttgaaaa
|
48901aagctcaatctaattggtcaggacaggtcattgtaagttttctaggaagaWtctgaaaac
|
48961ttcaggccaagattccattttacctgcagaaaatgaagagactgccaaggctaaaccatc
|
49021tcctatcaatacctgcaatctaggtaaaacattcaaggactatggatgcttgttcactaa
|
49081caagactaaaaaatcataccaattagctgatgtaaagtctcctaaggaatctggattcat
|
49141cacatataccaattaagtaataatccagccacagttcctttcatggatataaaaatattt
|
49201tttcttcctgtgagttatttttgctctcaagtgagaaatcatttaaaagttgaggaagta
|
49261gagaagttccttcatctctagtcagggcataaaacatgagagtgaggaccaggctcacca
|
49321cataactcaagagttgcctttaaggattgcaaggttgcttaaggttgtcaaatcttaaaa
|
49381taccctgtaacagtttattcattattaactgctgtttacagaatagtttcaagctataat
|
49441ttaagtattaataaaataaaccactaatttatttttatgttataaattactgaaaattca
|
49501gaagacaaaaaacagagctcccaataattctagtattttaatacaggtacttttagcatt
|
49561ttgatgtatttctttcgttttttctaggtaattttttttaaactgtagttggaattatca
|
49621tgtgtgtgtatgtgtatgttctatgccactcttctcactaacataacagatgcattattt
|
49681catgctactacagtttcataaaatttgctttagctccacaacttttgtttaaattgaaaa
|
49741cattctctatactatatttatatatatttttaagagacaggctcttgctatgttataggt
|
49801tggagtgcagcagctatttacagatgcaatcatggctaactgcaacctcaaactcccggg
|
49861ctcaagcaattctcccatctcagcttcccaagtagcagggactacaggtgtgcactactg
|
49921atcccagcacatataactatactttaacattttcatgcatgttctttgtttKtttttttt
|
49981tttttttttttttgacacaggctttcactctattgtccaggccggagtgtagtggcacga
|
50041tcacagctcactgcagcttcaacctccacagcctcaggtgatcctcccacctcagcctcc
|
50101taagtagctggaaccacaggagcacaccaccacacccagctaatttttgtattttttgaa
|
50161RaRacagggtYtcaccacgttgcccagggtggttgcaaacttctgagctcaagtgatcct
|
50221ccacctcagcctcccaaagtgctggcattacaggtgtgagccactgcacctggcctcatg
|
50281catatttattgtgacttttcagaaaaggatgtaagtagctgctataaataaaactagtct
|
50341taggccaggcgcagtggctcatgcctacaatcctaacactttgggaggtcaaggcgggtg
|
50401gatcactggagctcaggaattcaagaccagcctgggaaacatggcaaaacccagtctcta
|
50461ccaaaaatataaaacattgtattttttttgaggtcacattaaaattgaggtcagaagttt
|
50521gagaccagcctgggcaacttagcaagaccccatctctacaaaaagttttttaaaattagc
|
50581atggcatgtacccctgtggtcctagctacttggggggctgaggtagaaggatggcttgag
|
50641ccccaaagtttgaggttacaatgaactatgattacatcactgtactccagtctaggcaac
|
50701agaatgagactctatgtctattttttaaaaaaagaaaaatggttggctctccaattggcc
|
50761ctgattaatcagtactcagggtgaatactaaaatatcctgtgtcaactagcatgcccagg
|
50821aagtattttaaatgtcaagaactatgatttattgagataacatgctaaatgactgcatgt
|
50881atgtgggtacttgtgcacactatatgtatctcattatccttgtaattaccccatgagata
|
50941ttttattttattttttcatggtgccaagagaaattagaactttatgaggtattttaattt
|
51001aaaatcatccccattaaaaaaaatgatactggccaggcgtggtggctcacacctgtaatc
|
51061ccagcactttgggaggtcaaggagggcggaccacgaggtcaggagatcgagaccatcctg
|
51121gccaacatggtgaaacccgtctctactaaaaatacaaaaaaattagctgggcatggtggc
|
51181gtgcacctgtaatcccagctactcgggaggctgaagcaggagaattgcttgaacccagga
|
51241ggcagaggttgcagtgagccgagatcacgccactgcactccagcctggYgacagagcaag
|
51301actccatctcaaaaaaaaaaagatactgaagatactgagaggccaacttgccctgggtca
|
51361gagagaccagtgctgtgattctatgctgggcatgtgactctgagacccatatttatcacc
|
51421acactccatggtctcctctgtttctttagctttatttattatttttatatatatttttga
|
51481aacatggtctcactctgtcgcccacgctggaatgcagtggtgcaatcatggctcactgca
|
51541gcctcaaccttcagggctcaagggatcctcccaccttagcctgccaagtaggtgagacta
|
51601caggtgcacgacaccatgcccagctgattttttaattttttgtagagacaggtttttgcc
|
51661atgttgcccaggctggtcttgaactcttgggctcaagcRatcctcctgcctcagcctccc
|
51721aaagtgctgggattacaggtgtgagccaccacatccagcctctctagctttaaatatcca
|
51781atgcactctattattttttcatttgccactgtctctggtagaaaatgtatgaatgatcta
|
51841gcaaaagaattttgatgaagtaatcggcaaggcaacatttgctgatggacaatggcaaca
|
51901gacagaaaggtggtaagagagtgatgagaaccttgtcctagattaaaggcctttgaagac
|
51961caaagtccctgcatatgttgatcattaaggtcagcatttaccacYccccctttttttttt
|
52021ttaattttttagaccgagtcttgctctgttgcccaggctggagtgcaatggtgtgatctc
|
52081ggctcacagcaacctccgcctcccgggttcaagtgattctccggcctcagcctcccgagt
|
52141gactgggattacaggtgcccgccaccacagccagctaatttttgtatttttagtagagac
|
52201gggggggtttcaccagcttggccaggctggtctcgaactcctgacctcaggtgatccacc
|
52261tgcctcggcctcccaaagtgctgggattacaggcataagctccgcacccggcccacattt
|
52321acccttttattcagaaaaatacacacagagcagatgaaaatgcatttccatgctgtctaa
|
52381aggaaaactatttagtctagaaatgagaagactttacatagccctggctcctacaaaact
|
52441cctctcctaactctctcaagcttcctggagaagtatagccaacaaaagagaggaagacta
|
52501cttacccaagagaggagtgcagccccccgggtggcgtggagtgtcatcttggtgatgcca
|
52561gacagtcactccaatgcgcctggaacccaagagaggaagaaaagcagttaatcatatcag
|
52621atatccatgatcaagaaataaaggcgaaatggttcaatttgccaattctcaacacttaaa
|
52681tcactcttcactgaatccaccaagacaccatgggaatttttagaaagctgagtacacatg
|
52741acaattactatagagcttacatcagagacgacaggaaagaattgtgcatttaactcaatg
|
52801tctaccccatgtaatttttcagttccacagaaaatacaacatccaaagctggccttcaac
|
52861cctactctttgggacatgatgcccttaaatatggaacaaacatggttttcagacagacct
|
52921gggtctggatgctgatttaatgtgaccagggtcataggaccttagacaagcaacataacc
|
52981tctttYagtctttttctttatctgcaaaatgggatccacatacacctctctgggttattg
|
53041tgatgcttaaagataaagcaaatagtacggtgcctggcacatggtaggttgtcaataaat
|
53101aattactgttcttaagcagaaatgttgatttctagctctttctacaggtacccaaattgt
|
53161acctaacaatacctaagtccttggggaaactgttctagtttctggatttttatatcctcc
|
53221acagaaatgtctcacaaacacagttcaaatgggggattgagaatatccaaacttaggtct
|
53281ctggatgaggtcgagcccaattccggaggagatcccatgggacatttaatgaaaattaSg
|
53341cacctgtcctggtgttctcatccccaatttcctttcccattgagattctgccacctgcct
|
53401gccaacccacccaagagaccacagaccagattaactaaatattcaccaacacctcctagc
|
53461aacccttgcaattttcactaatctccaggggcacaatgagccctgcccccatctcctgcc
|
53521acacgtgctcagtctgtaattactctagaaggaggaacaagagtggtaagagccacatca
|
53581cttgtaagtctccccatatattagcatctccagagtgtgggctctgtggaaccagtctca
|
53641tgtatgcaagttggggataaagaaagacaccattcttgcccagaaggtgctcactgtcta
|
53701gtaMgggaaagagatacgaaaatctgaaaattcactccccattatctcttggtccttcct
|
53761atccaagtatactctatttatcagccaaccgaaaggtattttcttagttcctaaatatga
|
53821tcatcctcgctgggagcagtggctcacgcctgtaatcccagcactttgagagaccaaggc
|
53881gggtggatcgcaaggtcaggagatcgagaccatcctggctaacatggtgaaaccccgtct
|
53941ctactaaaaatacaaaaaaattagctgggcatggtggcgggcgcctgtagtcccagctac
|
54001tcgggaggctgaggcaggagaatggcgtgaacccgggaggcggagcttgcagtgagccga
|
54061gatcgcaccactgcactccagtttgggtgacagagcgagactccgtctcaaaaaaaaata
|
54121ataaaaaaaaagatcatcctgtgctagaagccacatggaaaatgggagacaatgacatgg
|
54181tccttgcctttgaggggcttatagcagggtagggagtaaaattaaacatatgtgaagcac
|
54241taacagaagaaaataattaaatgctaaatataactaaatgctaattacaattaagtgctt
|
54301cctgaccctgcaacatccaacatgattccacatgtcataccagcatcagtcttggaattg
|
54361agccaattcacctgggctttggcaagggcaaatgaaatggttaagagagctctcaggagg
|
54421gcagaaaagctaaggggcttatgttcctcagtcttggataattatcatcaagtataccct
|
54481atccatgggcaagattatgtagcccttgaggccaggcatggatggatgcagatagcccca
|
54541actactgcactgcaataaggcttttctgtggctgacaagactaaagctcgagggaccaca
|
54601cttggctctgtggtSgggcggcaacagccagacactcaactggggtttctttaaaaaaaa
|
54661ggcctctgagctattaaatcacaaggaatgaggctgagatcaccgctcccccatcctcac
|
54721tgctgcctatagacttgcagtccttttgatgaggcccaacacttcgaaattttatctgca
|
54781actgtaggcagatcttgccccctttgaaagactcacagctgtgctactaaaaatgtcctg
|
54841aggtttaaccaacctcttcatctcagaggcaaaacatacaaccctgaggtcctcccagga
|
54901gagcctgtctaaaactagttccactgttcaagaaaatgagtgtcaaggctaaatattctt
|
54961ttctgtgttccccaggcacagaaatacgaggaacccaatattcaccactaggaactcctg
|
55021aaggaccttgtctgctcttcagttctaagcctgtaaagaggtactttcctagagacagaa
|
55081catcagggtgagagaggcttcaggagagccccagccattccctcttctctgggtaaggaa
|
55141tgactgaagccaggagcacagctaagtcttctacattgggactatagctttaagcagact
|
55201ttggctgggaacccaagggctcccagccagagtaccatcctccccaccctccccctgaaa
|
55261tctgaggcaggccccacccagtacactgggtgatgctgatggaaaaMcagatccttgcga
|
55321ttgtagcctggaaccatttcacagaaggatctgctgagatccaccccagctggatcaggc
|
55381accccccgtcccccccacaaccctcactcaataaacaaagaaacaaaaggccaggccctc
|
55441tgagggcacctttggagttcccatctacctgattctctgagaaagaaattcccccagaat
|
55501ctaaaacagaggcctcaccgagctggtaaggcaccctctcttttccctggtctcaagaag
|
55561taaccaaggacacagaagcagttgcgttataaacttaaggccctgcatcctttttacatt
|
55621tcccaaactgacacaatgcagctcccccacatcaggacaaattcccacatttacagtaac
|
55681ccctgtttccagaaaataaatatcaagataaggaaagtgacactaaagagacacgcagcc
|
55741actctgcctgtaccctctctggaccttaaagagttaaagcctagccatgatttcctacca
|
55801gggctgaggctaatgtaaaccacctgctcagacRcaagaagcaggaccagagggtcaagt
|
55861tgctgagctctgaagtctgttctgaaaaagcttcagttttaagtacagaacaagtgatag
|
55921gccaaaggccagagggtctgagctgcagcagcactgctctccttaccccgcccttggcct
|
55981gggtgccagctcctttgagactgcctcttagccacttactgcccatcaagggaacaccag
|
56041acctacctcaagataacaccaaagtgacctttggtcccagagagttgttaaactataccg
|
56101atctctcagctcatgggcccttgcttctgctgaaccctcattctcttagtgctaactccc
|
56161actcccagaatttcagggcccaaagcccacacaagctcccacctcaaagggtccttccca
|
56221gaaccccacccccttctccacctgatagttccaaaggcctacagcctcacagctcacaaa
|
56281ggaaatggctgccccatctgtgcgccagtgctcacttgcaaaatttaccaccacttaccc
|
56341tgagacgctgcctgcctgtagcctaagaattccatgctctgtacccctttcttagaaaga
|
56401tactccccatctgagagacactcacatccaaagagtgaaaaccctgatcttggggctcct
|
56461cctcctccaactctRggacggataggccaggaggcacatgcaagcaaacaccgagatctc
|
56521acctggcaggttacccagaggggccaagccaccttgccctaggctaataagctataaaaa
|
56581cagcataggaaatactttgctggtacatcccctgcctctgagaagataaaaggcaagagg
|
56641accagtggctccaagagacgccatacagagaaaaacaatctttctcaattcctggggagt
|
56701cctgggtagaccgtctggtccaagtccaaagagtttcctgaggtcggggcaaaccagttt
|
56761ggtccatctaaagggactagcttgggctgaagcctcctcttcacacagaccactccatct
|
56821ttgtagcctagagtttggcacagaaccccaaagccctggagaggaacaagggagggatta
|
56881cagaggaaaccaagcttctctggtttcttcaaaagtggcttacagatgtctgccccttct
|
56941ccccgttctctggagggtccagatcaggatgatggcaaaagagctgcaatcaggaaccag
|
57001acctgcaaccaggcctgcagccatgtattgtactggggcgcgtacacatacaYacacaca
|
57061cacacacacacacacacacacacacacacacacacacacacacacacacacacactgacc
|
57121tgggccccccaccactatattcacacaccctggtccctatcagctgacaaaatgaacctt
|
57181ttttcactgcccaccaccgtgcacacacccacggcctcacgcagaaatggtgaagccctc
|
57241tcctgagctgtctctacagctcaacgtgcaggcaaacacgctttccttctctgaacaaaa
|
57301acatgctgacatctacgcaagggggaaagaaagcaaccctttgctctgaaaggcNccaac
|
57361tcccggatgttggcaagctctgctccacagcgcctgtttctgagtatgtttacttgctct
|
57421ccctcttctctccctcccctttaaggatggcgcaggaaagggaggtgaggggggagaatc
|
57481caccccaccccctcgtccatgtttgaacaaaaacccagagaaagagtgagggagaaaaag
|
57541tctcggtgcgggggggccttaccagactcctaaagccaaacgtatctacaggttttaatc
|
57601cgccattagcatttaaatcttgaaaggagaggaggaagggggggccagtggaaagtaacc
|
57661ccacacacaaaagaaaagttgttggttttcttctcagtctgcctggcaggagcgatcKtc
|
57721ctggctgacagccagaagtgcgtcacagccaggagtctgctttctttaaaggcacagcaa
|
57781gcttccccgatctgggagcgacagcaagcaggggactctcagtgggggtggggcccagag
|
57841ggagggggtgcactggagaggaggggctgcaaaggggaaggctggaggcttggtccacga
|
57901acaagaaaagcaggacgaatgggggcggcgggttgagggtgaaggcacaagcaggcaggc
|
57961aaaattactgaactccaacagcagcaagagccaaggcaaactgtggcataaacacacaaa
|
58021acacatcttacagtggcctgcctgacaaactgggatcaaccggacactcccccttcgctc
|
58081tgttttccacccagagtttaaggcagcagtaataatctgtccatctctctggacagcaat
|
58141ggaagggtaggacaagggctgtcctgataattagatcagcccctgcctggcggaccgcag
|
58201ggcaaggaggaagacccgggaacagaggctttgaagaacaagcaacatgcaggccctctg
|
58261atcgggggcaccttcctgccggccccagggcaggctgtgtctttaagtacaaccatgcca
|
58321ctcacacacaaagcgccctgccaccttccatgggcaccgcctgccctgctctgggacacg
|
58381gccacccactaaatccattccccgagggaatctctccagcccataccttctgcgtggcaa
|
58441ggccaggatgccgtgctgtgcccgctcctccccctccgccacccaaacaagaagcccagg
|
58501cagattctggccctggagtacaggcctgcgctgtcctgtgctgcgtgctattgtcggctg
|
58561tggaatggccgccaaaatcccagctgtgctgccagaacctaatcccctgttccgctgagc
|
58621atttatggggaggggctgaggggccaaggcacgagaccgagtacgccaggcactggctgc
|
58681agcccttaacagacgcaggcacSgggacttgtagactctgcttctcctacatggctgaaa
|
58741acaaaagatgtctgactcttagaagacaaaaYcacagcatttccccccactgaatagcga
|
58801acttcaccaaggctgaaagggaagcccaccagatggtcaacaggcaccccctaatcttat
|
58861gccacaaacatttactgagcacctactatgtgtaaggcactcctataggaaactgtagga
|
58921agtatacaaagatgaattaagcccagcatccgcactgaggtaggttgtaattcacaggag
|
58981ataagaaatatgacttgaagattaatttcaaactggtgtgctaacttccataaaagctgt
|
59041aaagaaaaattctaaccagtttagaatagggaaggattacgaaaatgaagtgccatttta
|
59101atttggaccttgaaacacacaggtagcatttccccagatRgaaacagagaggtgtgggga
|
59161ggaagagaaagcagagaggaggcatggaagcagtgggagaaagggcttgaagagtgaggt
|
59221ggggtcagagagctaggagaatcttgaacctcaaaccaaggaatcaaagacttgtaagtt
|
59281tgtttgttattaacacagagctgtggtatgacaaaaactgtgccccaagtttattctgat
|
59341atatacctgaatgagactagcagcaatgaggtgagtcaggaagctgcacagtcaggagac
|
59401aggtaatgagggcacacaagagggtaaggtaagaaagaatggaaaggggScttggcacga
|
59461Yggctcacacctgtaatcccagcactttgggtggaccactgaagtccgagagttggagac
|
59521cagccggggcaacatagggagatcccatctctacaaaaaatttcatgaataaaaaattag
|
59581ccgggtgtggtggcccgcacctacagttccagctacttgggaggctgaggtgggaggatc
|
59641acttgaacccaggtggaagctgcagtgagagacattgtggagacagggtaaagaactgat
|
59701aggaggcagagagaggaactgtacaggggaggaaagtatgagggatgatatgcagaatta
|
59761aactgaggagatgacaggatgtcagaacaagagagaaaacagagtataataaatagtagc
|
59821tggtggggcacggtggctcacgcctgtaatcccagcactttgagaggccagcctgggcaa
|
59881catggcgaaaccctgYttctaccaaaaaatacaaaaaaccacacaaaaaaacaaaaacaa
|
59941aaaattagccaggcggagttctttttttttttttttttttttttaaagcagggtctcact
|
60001ctgtcacccaggctggagggcagtggcgagatcatagttcactgtaacctcaaacttctg
|
60061ggatcaagtgatccatctgcctcagcctcccaagcagtgggagtacaggtgtgtgccacc
|
60121atgcctggctaatttttttttttttttttttctgtaRagacaggctctcactatgttgcc
|
60181taggcacagcattattttaaattcttctctaaaaattctatgcttctcccaaagccctgg
|
60241gatacaggcatgaaccaccacacctggcccacagttgtctttgtctttttctactaggag
|
60301ctatactatagaggtcacaatcattggctacagtttataatatataggctaaaatgtttt
|
60361acatataaRataaccagtaaaacttcatgatttaRaaacaaattagtgtcttttttagtg
|
60421tcaRaRtcccagctactcaggaggctagggtgggaRaattccttgaactcggaatgagca
|
60481gagatcatgccactgcactccagcctgggtgccagagcaagactctgtctcaataaatac
|
60541ataaataaatggacagatagataaacagagagacagaaagacatatagtagctaatgctt
|
60601actgagtgcatactatgtacRcgacactattctactgacctaatatgtacgaactcatta
|
60661atcttaaaaactcccttaatgaagtaggtaccattatcacccaactttagagaggaggat
|
60721attgagccacaagattaaataatttgccaagatcacatagcaagtaaatggcagaagtct
|
60781ctaccacatgctgctaactatttgacattggcaagaaacttctgaactttagtatcccta
|
60841tttgtaaaacaagaataaagacacctgttataaagcaatgaaaattaattcaataacacc
|
60901tataaggtgtccaacacactggctagcatgtaaggcataggatgggtgtttcctgcagac
|
60961taattcctacttggcattttggtcccttgtcaccaaggtgtccaagcagaagttggctca
|
61021ccaattgtttgggaagccagagagggtattctgcctggagcaggagactggatcctctgt
|
61081ctgtctgccttcttcccatcagtctgcctctctagattttactttagggtccagctcaaa
|
61141tatttaatatatttgatttaatattcctaactcctcaaatatttaacagttaacaggggt
|
61201tactttNgSgggggggaggagttagattgtagggaacattcacttggggacttYctatgc
|
61261tgtatgtttgcttttttttttttttttttgagatggagtcttgccctgtcacccaggctg
|
61321gagtacaatggcatgatctcagctcaatgcaacctctgtctcctgggttcaaatgattct
|
61381cctgccacagcctaccaagtagctgagattacaggcacctgccaccatgcccagctgatt
|
61441tttttatttttagtagagacagggtttgaccatgttggccaggcttgtctcgaactcctg
|
61501acctcgtgatccgcctgcctcaggctcccaagtgctggattacaggtgtgagccactgtg
|
61561cctggccttgcatttatttttaataatcttgtattacactggtgataagaaaaatgtaac
|
61621tacctcctactcttggcacttatgtgtatatgcatgaaaatcttgtcttcacatctagaa
|
61681tggaaattcctcaagggcataaccagttccacctctctctctctgtgatcccccataaca
|
61741cctagcacactagggctccttaaatctgcttctccaaactacatctggatgtcaggttta
|
61801caaattcaactttctggccaccagagaatgactgtggtgggtggttgggatgaSgtgggg
|
61861gtgggggtcagaccaaggctcattgctgtaggctccccatcacctgctgcttcttccagg
|
61921ccctgtaagctattcccactgtatcatttgtagtctgtagttagcaatcactattagtag
|
61981aaatggaagttcttatccaaaggagcaccatgaaagcaaaggcaaagcagataccaaaac
|
62041ttttacagaaaagcaaagtggcaaacataattgtttgggtttttgttgtttttgttttct
|
62101tgagacagtctcactctgtcacccaggcttgagtgcaagtggcacaatcatggctcactg
|
62161cagcctcagcctcctgggctcaaacaatcctcccacctcagcctccggagtagttgggac
|
62221cacaggtgcatgccaccacgcctgactaatttttgtatttttttgtagagacagaatttc
|
62281accatgttgcccaggctggtctcgaactcctgggctcaagcgatctgcctgcttcagcct
|
62341cccaaagtgctaggattacaggcatgagccatcacaggcctggccaaacttaatttaaag
|
62401actggcattatcaatgctccagaaaatgtataaggtgaaaataggagggaggcctgctaa
|
62461aactgccctggccacatatggcaatgcatcagccctgaagcttcctagcccagatagaat
|
62521tgatattgtctcaaaagcgtacaagaggtctccccagcctggccccttgctctaaactca
|
62581aggcaacagcttccagctgtgcagcttccgagaggctgaaccttcccctagaacccctct
|
62641gcaaagctgccaagtttctgggccagctcttcaggacagcccaaggagcctggccagttt
|
62701cgccaggctttccctcctcttcctccctcctgtggcagcagcagaatttccacagcccct
|
62761ctcacagcctagacaggcagcaggcggccacatggctcctgcctgattcttactgtcctc
|
62821agaagagcgggaaaggagtggtaaaacctttctagaaaaagagaagggccgggcacggtg
|
62881gctcacgcctgtaatcccagcactttgggaggccgaggcaggcggatcacctgaggtcag
|
62941gagttcgagaccagcctgaccaacatggagaaaccccatctctactaaaaatacaaaatt
|
63001agctgggtgtggtggcgcatgcctgtaatcccagctattcgggaggctgaggcaggagaa
|
63061ttgcttgaatcctggaggcggaggttgtggtgagccgagatcRtgccattgcactacacc
|
63121ctgggtaacaagggtgaaactccatctcaaaaaaagaagaaaaagagaagaaagaaaggg
|
63181gtggagagcggggagagggagagagagagagagagaaaggaacaaaggaaggaaaagaga
|
63241gaagaaaggaaggaaagaaattactttaaattcagtagggagggctgggcacagtggctc
|
63301atgccttaatcccagaactttgggaggtcgaggtgggcagattgtttgagctcaagagtt
|
63361caagaccaacctatccaacgtgacaaaatcccatgtctactaaaaatacaaaaattagct
|
63421gagtgtggtggcaggagcctgtaatctcagctacttgggaggctgaggcaagagaatcac
|
63481ttgaatccgggaggcggaggttgcagtgagctgagattgcgccattgcactccagtctgg
|
63541gtgacagagtgggactccattgcaaaaaaagagaaaaaaaaagaattttaaattaaaata
|
63601aataaataaatttcagtagagttcagatagaggttgaagcggggtggtgactggttagga
|
63661gcacaaaggttatttcaaagggtcaggtgatcctcctgcctcagcctcctgagtagctgg
|
63721gactacatgcacatgccatcgcatcaggatttacattatcatttttgaaagtttaaacaa
|
63781aaaaagactggagctgggtgtggtggctcatgcccgtaatcccagaactttgggaggcca
|
63841aggtgggaggataatttgagctcaggagttcaaattcctcaggagttcaagaccagcctg
|
63901ggtaacatagcgagatccccatctctacaaaaaataaaagaattagccagacatggtggt
|
63961gtgtgcctgtagtcctagctactcaggaggctgaggtgggaggattgcttgagtccagga
|
64021gtttgaggttatagtgagctatgatcatgccactgcactctagcctgggcaacagagcaa
|
64081gacacgtctcaaaaaaaaacaaaaacaaaaacaaataagtactaggagagttcaagtccc
|
64141cagtcatccccatgggatgattctcacacaaataattagcctggcactcaaggccctcca
|
64201tgacctgcagcttctagagttctagcttctagagtcgttattcccttacccaaaccctcc
|
64261actctgccaggcaggtctataaagttacagtttgtcctgagaattagacaagatgaccgc
|
64321aggggacaggctctggattagctacgaattacaacagtaacagcaacgataatgatagtc
|
64381tttactatgccaggatgtaagtgacagagaaaagactagaaggcattgtattgggcagtt
|
64441ttgtttattttactttatttttttaataaaattaaaaaatatatggaactcttcacaaat
|
64501ttgcatgtcatcctcgcacaggggccatgctaatctctgtatcgttcctattttattttg
|
64561ttccaattttagtatacatgctgccgaaccaagcactgggcagttttaaaaatgaagaaa
|
64621tctgaggctcaggaattaggtgacYtacgtgatctagtcatgtaagtagtaagttgtcta
|
64681ccttgtccctatattattcttttttgtttttttctttcaagatggagtctcgctctgtcg
|
64741cccaggttggggtgcagtgctgcgatctccgctcacYgcaacctctgcctcccgggttca
|
64801tgtgattcttgtacctcagcctcccgagtagctgggataataggcatgagccactgcacc
|
64861cagccagcctatattattgtctacagctgttaaataggcaatcattgagtgaatgaataa
|
64921aagctagcacattctcagcaaatcaaagaagccgtgtgcttttcctcatgaaaatcaacN
|
64981ttttttNattttttgagacagagtttgctttgtcgcccaggctggagtacaatggcacga
|
65041cctcagctcactgcaacctccacctgccaggttcaagcgattctcctgcctcagcctccc
|
65101gagtagctgggattacaggcgctcgccaacatgccggtctaattttttttatttttagta
|
65161gagatggcgtttcaccatgttggccaggctgggcttgaactccttacctcaggtgatcca
|
65221cctgcctgggcctcccaaagtgctgggattacaggagtgagccaccgtgccaggccgaaa
|
65281atcagcttcttaatcaaaataatcaaacagctccaatttcaaaattaatcactaaagaat
|
65341ttttttctgaggatccgagagctttacaaacactRaagggccaaaactcctctaaaaaca
|
65401gcaagcaccaagaaaagtcttgtactaggagggatgttggcagtgtctcaagggttagag
|
65461ggggaggctggaaggaaatgctggtgctaaagggaaggactgctgtttcaggagcctgac
|
65521cttgagcttatttaccatggcctcattgtccctctccagaRgataatggctgattaatga
|
65581ggcagtgttggtaagtctgaggcttcctggagagaaaagcagagggcaaatcaaaaccca
|
65641gagaggattcattataacatccaacaggcccactcagttctctctcaagaaggcctttct
|
65701acaaaacagctaagaacctctccaccctgtttcactgtcacagaggagtaaaatggctct
|
65761gtccctacaggcaacatatcaacatatctagcacaatgtttgctcacaaacacagaacta
|
65821attataagaaatgtgaaagaacctgaaacgcagggggaatactcttactggagacagcct
|
65881ccatagtggtagaaaacatagtagatctggtgttgaaagcccctggaggggtgatgggtc
|
65941acttactagctatgtggcttaatgcaagtcacagaggcaaattactgagaaccaagctag
|
66001ggtcggatcagctctaaagtaccttttcagggccaggcacagttgctcatgcttgtaatc
|
66061ccggcacttttggaggccaagatgggaggatcacttgagccaaggaatttgagaccagcg
|
66121tgggcaacatagtgagaacctgtctaaaaaaaaaaataataataatatatatatatatat
|
66181atatatagtgtgtgtgtgtgtatatatatatatatatttgcctattcatctatctataga
|
66241tagataaataaatagatatatatcaaaaaaagaaaattggctaggcatggcggttatgtg
|
66301tctgtagtcctggcaacttgggaggctgaggtgggaggatcacttgagcccaggagtttg
|
66361gggttacagtgagctatgatcatgccactgcactctagcctgggcaacagagtgagaccc
|
66421tgtctctaaaaaaataaaataaagtacctttccacttccaaaaattcccatgattctttc
|
66481cacaggataccattctcaacaacaaatcttgtagtagaacttgtctcctcagaatctggt
|
66541caaaacatcactagttagggtgttctttcaaaaaaaatagcaaatctcctagaaacaggc
|
66601acattgtgtgttaccctattaggacccatccccaaagcgaggcacatgtgggtgcttcat
|
66661taatactctgttgaaaggaggaggtccttggaaactggtagtaccaacttagcatggcat
|
66721acaatgaaaggtgattggagccacactcgaggaactacaaggcagcttttcataaataaa
|
66781agccacaaaatgcaatttataactacatctgtctaaacagactaaagaaaagtagctttc
|
66841tatacctaggtcttcaccccttctcctccccacctctctactttatcatccctgtcctac
|
66901acagcactgagacccgtctttctggttccaggtccacttttcctttttccacaccagaat
|
66961gcctttaatcactgatagaaatgaacaaacatgaatatgagttctaaacaggaagacaga
|
67021tagcctcaagaaccaacttgtcaatatgttactaataagtgaaataagtgggaatggtgt
|
67081ctaacatgggcatgataaaataaaaccctaaaatacatactgtgctagggatttgaacaa
|
67141acttcaggatttttaaggaaggctgtgtctcacatctcaattaatcttcccaaaagaacc
|
67201ctaagaggcaaggtttattccaattttataaattaggaacgtaaggctcagtaaaaagaa
|
67261aatacctgcctcaaggtcgactggtaaggctgcagagccagaactcaaagagatgtcttc
|
67321taaatccagtgctctctccagcacatctcagctacatcctctatctttctcatcagtata
|
67381ggtcttcatgtatacaaagcatttctgcattcattgttcacactgcttctgccacagctc
|
67441atgaaaaggacaatgcagatgtctaaatggcaccagatctatacccaccttttttttttt
|
67501tttttttttgagacagggtcttgctctgtcacccaggctggagtgcagtggcaYaatcat
|
67561agctcgctgcaacctcaaacttctgggctcaagtgatcctcccgcctcagccttacaagt
|
67621agctgctgctacaacaggcacgYgccaccacgcctggctatttttaatttttagtagcga
|
67681tgaagtctcgctatgttgcctaggctggtctcRaacacctgggctcaagcgatctgcctg
|
67741cattgacctcccaaagtgttggaattaaacggtgtgagccaccgtgctgtcctatccaca
|
67801cttttaaagatgctaataaataacgtgatcaccatcagagaaaataaatcctacgtatct
|
67861ggcatcactgagaagtacaaaatttcacacaagcaattttcctactaactgaaatttatc
|
67921ccttttaaggcaaagctctttctttatatcaaaacatattctccaaaatacataagatat
|
67981gttactctttacttagaattaatgaaatttaatcagggatattcgactataaacatgata
|
68041taaacatcctacatactgtgctaggaattcaaagatttttttttttttttttgagacaag
|
68101gtctcactctgctgcccaggctggagtgcagtggtgcaatctcagctcactgcaacctcc
|
68161acctcccaggctcaagtgatcctccctacctcagcctcccaagtagctggggctaccggt
|
68221gtgcaggaccatgcccagctagttttgtactttttgtagagatggagttttgccatttgc
|
68281ccaagctggtctcaaactcttgagctcaagcgatcagcccaccttggcctcccaaagtgc
|
68341tgggattacaagtgtgagccactgtgcctggcccaagggtaaatctttaaacttgagttt
|
68401ataatcttgtagaggaagagacacatctgtaaccataatatgaagccaaagaacatgggc
|
68461ttggggtgtgctgaaaggaaggtaagataacacaagcaaggctagtggggaccaacaacc
|
68521cagggtgacttactgaagagaagtgggaggcactgaaaagtcctgggcaggagaatggta
|
68581tactacttgtgctttttgaaaagatgactctagcacaacagtgaggccagaggcagaaaa
|
68641tggacttaggtggcagcgacagaggtagagagaaaactgcactgccagggcaggggcagt
|
68701aggaactaaaacaggtggctctgaaaggcattacagacgtagagacaatgctcttagcat
|
68761ataggggcgtgggaaaggtggggagctaaagagaacactaagattcttgctttcatggaa
|
68821agatttcagaaYgagaaaataagagtaggtactggtttaaaggagcgtgagggactaact
|
68881caggatgggatgatggggaatgctttatagaggaagtgacatttaagctagatattaaaa
|
68941tatgagcaggataagtagagtttcaccaaaaagtaaaaaagcattctaggcagagaaaac
|
69001agcacatgcaaagacagaccatattacagttgaacaatggcatgcagttttagggaggtg
|
69061catcagatgataagaagggtaataagtaaggccaggggcggtggctcacgcctgtaatcc
|
69121cagcactttgggaggccaaggcaggtggatcatgaggtcaggagattgagaccatcctgg
|
69181ccaacatggtgaaaccccgtctctactaaaaacacaaaaattagctgggtgtggtcacat
|
69241gcctgtaatcccagctactcaggaggctgaggcaggagaatcatttgaacccaggaggtg
|
69301gaggttgcagtgagccgagatcatgccactgcactccagtctggtgtgctccagtcagag
|
69361caagactccatctcaaaaaaaaaaacaagggtaagtaatattaaattgtgaggcacttgc
|
69421ctcatactaagaaattgtaggtgatgagaagacaatcaaggtttctaaaggaagagggta
|
69481aaggggagcagcatgatcagggctatgtttcagaagggaaactgtataaagtacagactg
|
69541gaatggtaagacacaggaggaaggcaatagagcataatggctaagattacaaggtctgaa
|
69601cttaagacaacctaatacaaattctgggtttatagcttaatagctctgcaaccttgggca
|
69661agttatttactctctctgtgccctcattttccccagctgtaaaatgggaataataatagt
|
69721actttatcaggcacaagccaccacacctggctattttatttttaatttttgtagagacag
|
69781gatcttgctatgttgtccaagctggtctcgaactcctcaactaaagtgaagctcccacct
|
69841tgtcctcccagagcactgggataacaggtatgagccactgtgcccagcccatagttccta
|
69901attacgcctttttgtattttattaatttatctttctcttactgccttaagttccatgaaa
|
69961tcacaaactgtgtgctcaccgctgaattcttagaaatcagcacaatggctggcacagcat
|
70021gagtgcttgataaatacttcttgaatgaatgaaaggttccaaactatatattttaaatga
|
70081actctatttaaatgtaacctttatatagaaccccaggacacacagaagaagacagtttga
|
70141agtaagggatatttggagacttgttccctctgcttccccctggKtcttaagtcagttcta
|
70201tagttctgtaaagctttacagaatgcagtgcaaaaaccattgtctgttacaagcaagaag
|
70261taatgtatgtctgaagtaaggcaatgacaataaagatgcaacaatagctttgagaactat
|
70321ttatgacaggccctgacaaccaattacagtaggccctctgtatccatgggttccacatgt
|
70381gtggattcaaccaacctgagatgaaaaacattttRgggaaaaaaaagcatctgtactgaa
|
70441gatgtataaacttttttttcttgtcattattctaaacaatacaatgtaacaactatttac
|
70501atagtatttacattgcattatataagtaatccaaggatgatttaaactatacgaaggacg
|
70561tgtgaaggttatatgctaatattataccattttatatagagacttgagcatccaaggatt
|
70621ttggtatctgtgtgaagtcctggaaccaatccccacagatgctgagggacaactgtataa
|
70681atgaagaatgagaaaaggaaaattcttgaagcacctctaaatttcctagcttgagtgaac
|
70741aaataaatgaacatgtgtgccaaaaagcaagataagaatgtaagagtggctgggcacggt
|
70801ggctcacgtttgtaatcccagcactttggcaggtcaaggcaggtggatcgcttgaggcca
|
70861ggagttcgagaccagcctggccaacatggtgaaaccctgtctccactaaaaatacaaaaa
|
70921aattagccgggcacggtggcaggcacctgtaatcccagctacgagggaggctgaggcagg
|
70981agaattgctcaaacccaggaggtggaggttgcagttagccaagatcacacaattgcaatc
|
71041caccctgggaaacaagagcaaaactccatctcaaaaaaaaaaaaaatgtaagagtaacaa
|
71101taacaatttccattcatttgaacatagtatcacccctatcaagcaaatactattaatacc
|
71161ctcaagttatagaataaatctttcacgatgttaagcaactgtcatgatcttcattagcaa
|
71221agatcatgaggctaataagtagcagaattaagtttcaaatccaagactgtcccactccaa
|
71281gcccaaaatctaaaccgtcttgctatattggcaagcagtttgagagttaggtcttagacg
|
71341tgagatatctactggatatacagttagaaataatcagtaactaatgaaaaatatgatttg
|
71401gggttagagataaggatctgggctccatttggaagactgaataaattcagaagagtgtct
|
71461atgagaagatcatgcttgcttgtaaggcctgtaaatgggtgatgtacgcatttgcgattg
|
71521aagtttgttgatttaccaaggtctctgccttgcatagatctagtgggcatcRgcattaag
|
71581agaggaagtaaaaaactttaggagaaattccagatctctggggattcctgttaggacctt
|
71641tatattatttttgttttgggagaatttaacagaaagacagtgacaccaatgtcaacaaaa
|
71701aaaaatgagacagcaaaggtgataaagagaaYagatttggggatcatcattttctcttct
|
71761gcttgagattccacagctctcaacaaaaatgactattatttgtgtatggctctttacaac
|
71821taacaaagtgtttcccatttacaaggtatttcctgtttaccaataatgtcagatgaacct
|
71881tacaacagctgtttaaggtgagggcattattattttcactttaccaaagaggaatgaagt
|
71941ccagaaaagttaagtttaccttgtctaaggtcatacagctaaaaagcaaccgggccacga
|
72001tgtaaccacggttttctggctcctaatctggggctctttccagaagactcacctgagata
|
72061acatgagccactcacttatgaaccaagagtcatcatccctatgtatagtttcactgtgtt
|
72121taaaaataaaacaatagggggatagtgactgggaaggggctaatggtatgctggtaatgt
|
72181tctgtttcttgatgtaggtgctagtaacacaggtgtgttcaccttgtggaaagtccttga
|
72241gctgtaaactttgtgtacttttctgtatatatgtcatactgtaattattaaataccaggc
|
72301aagccaggtcaggaggcttgcacttgtaatcccaatggctcaggaggctgagatgggagg
|
72361atcacttgagcccaggaattcaagaccagcctgggtgacaaagcaagacccccatctctc
|
72421aaaaaaaaaaaaaattcagctgggcgcggaagcttacacctgtaatcttagcactttgag
|
72481aggccgaggcagacagattacctgaggccaggagttcgagatcagcctgaccaacatggt
|
72541aaaaccacatctctactaaaaatacacatacacacacacacacacacacacacacacaca
|
72601caattagccaggtgtggtggtgcacgcctataatcccagctactcagaaggctgaggcac
|
72661aagaattgcttgaacctggaaggtggaggctgcagtgagctgagatcataccagttcact
|
72721ccagcctgggtgacagagtgagactctgtctcaagagaaacaacaacaaataaaaaaaaa
|
72781ttagccaggtatggtggcatgcctgaagtctcagctactcaggaggctRaggcaggagga
|
72841tcacttgagctcaggagtttgaggcttcagtgagctacgattgtgccactgtaccccagc
|
72901ctgagtgacgcagcaagatcccatctctctttttttttttttgagttggagttttactct
|
72961tgttgcccaggctagagtgcagtggtgtgatcttggctcattgcaacctccgccttccag
|
73021tttcaagcgattctcctgcctcaacctgccaagtagctgggattccaggtgtctaccacc
|
73081acccccagctaatttttgtatttttagtagggacagggttttactatgttggccaggctg
|
73141gtcttgaactcctSaccttgtgatccgcctgcctcagcctcccaaagtgctgggattact
|
73201ggcatgagccatcgcgcctgRccaagatcccatctctttaaaaaaaaaaaaaaaaaaaaa
|
73261aaaaggcaagccaaactgataatcaaaactcaggaacactaagttggatgcgtcacattt
|
73321tttactcaatttctcaaacagtagctacatataggacatctaccagttatataaggatgt
|
73381acaaaattcttgcacactcaaataacatatccacccaattgtcccaatccagactgtctt
|
73441agtgatgtgaaagaatctgacaggactggaagtaacagaagcccaggaaagggcggagat
|
73501ttttgttaatgaaaacaaaaatggcattgaaaatggaactatcctacatcatcatcaatg
|
73561atgagatatctcaatttcagagataacaaaaatgtgaaaaaaaaatggccagtgacaatt
|
73621ggaagatactatcaattgtaaaatacaccccaatttcagtgttaaaatattaaaaaagca
|
73681aaaaaaaaaaaaagaaagaaagcattttaaaacaaaggaaatatattctaatctcaaaag
|
73741gtagctcaattgtgggataacagatttgtgaagcacatctccttgtacaagctctttgtt
|
73801ttagagataaggacactaaagccttcatttaagttattaaataaccttactaaattaaag
|
73861ctcacacatcagaaagttgataactacaattacaaagctggttccttcaatgctcgttct
|
73921cctgccactacccagatgcctcctttaaatccaaaagaagatttacatattaattccata
|
73981ttaaaactctattttgactttcatatttctttacttcattaactcactaaaaaataataa
|
74041aagttaacctttaaaaatcaattaaagctgggcgaggtggctcatgcctataatcccagc
|
74101actttggaaggctgaggcaggtggatcacttgaggtcaggagttccagaccagcctggcc
|
74161aacatggtgaaaccccatctctactaaaaatacaaaaatcagttgggcatggtggcaggc
|
74221gcctgtattcccagctacttgggaggctgaggcatgagaattgcttgaacccgggaggtg
|
74281gaggttgcagtgagccaagattgcaccactgtactccagcctaagaaacagagcgagaca
|
74341ccRtctcaaaaaaaaacaaaaaaaaacaaaaaacaaaaaaacaaaaaactaagctgggtg
|
74401cggtggctcacgcctgtaatcccagcactttgggaggctgaggcaggtggatcgcctgag
|
74461gKcaggagttYgagaacagcctggccaacatagtgaaaccctgtctctattaaaaaaaaa
|
74521aaaaaatagctaggcgtggtagcaggcgcctgtaatcccagctactagggaggctgaggc
|
74581agaagaatcacttgaacccaggaggtggaggttgcagtgagccaagattgtgccactgca
|
74641ttacagcctgggcaacaagagcaaaactacatctcaaaaaaaaacataataataattaat
|
74701taagatgaaacgatgtttaggaaacttcatttcttgcttatacaagtttgttttccttgt
|
74761tcttcaaaaccagtgaagcaatacaaagttagataaaagacaaaattagtaatctcccag
|
74821cccctttccattcctctccaaggcctcctacaagatgagaaatggtaacatatttttgtg
|
74881tcccccaaaaacataaatacaaatatattggaaagggttttgttgttctctgtttttaga
|
74941aaactaggtttaaactttacacattgctctgcaacttatctcatctaacaatttatcaac
|
75001atctccccaagcatcaataactaaaattctaactcatacttttaaaaagctacataaaag
|
75061tccatataagggatatccataacgtgttcacatatttttctattgagggaatggctattt
|
75121tcagtgttaccatttcaaacaatgctgtaatgagtatccttgacgtatttcaagttaaag
|
75181aaaaaaaactatttctacacacatactttccttgttgtcccatgttttgattactcctgg
|
75241tctcatcatcatccctacctcccttgctcagagaatcatcctcagggtccagtgtgatga
|
75301cagagagcaaagtaacttggagaatgtcaagacaagacatgtgatagttactgttggtaa
|
75361attggaaatggcctgtcttggctgcctctctcagtcacttgcacatgctatccccctcct
|
75421ccccttacatgtgctccctgttctggtctcagcagctgcttccaactcaactgatgtgag
|
75481cacagctagctacYttgtcacactcctaaYcctggcaagtgcagacaggcccaggagctc
|
75541tccaaacaattggaaaggagaaggaatacattatcactgtgaaataatataatacggagg
|
75601tatctagagtaaaatgtaaaactccctcttcattaagcctcaacccacatttgccagtga
|
75661cactccccagctcagaagtgaccactgttagaagtctgttgtacaaccttttggattttt
|
75721cctaagcatgtacacatacaggtatatattcacatacaggtatgtgtgtttggtctacat
|
75781atctgtaatcataccatataatatgttctgcaacttgcccttttcaYgtaMaaatttatt
|
75841tgacatgtttccataccagcaaaaaacagattcctcacatttttaattaattttttttga
|
75901gacaaagtctcactctgtcacccaggctggagtgcagtggcaccatcatggctcactgca
|
75961acctcaaccacctgggctcaggtgatcctcccacctcagcctcctggtagctgggactaa
|
76021aggtgcRcaccaccatacccagctaatttatttgtagagatgggatttcaccatgttgcc
|
76081caaactgttctcaaactcctaggctcaaacaatccgcccaccttgtcctcccaaagtgct
|
76141gggattacaggtgtgagctRtcatggctggcaattccttaaacttttaaaagcttRaaaa
|
76201aatcctatgtaagaatgtgccacaactttattttcccattttgctacatctggacattta
|
76261ggttgttcacagtgttttgcatgtcaaagaatgctgtattgataacactggcagcacatc
|
76321tctaattttacacacaagctaatatttctctaggatatataccaataattagaattaWtg
|
76381ggttgaaaagcttgtgtattttaaatgtcaacagatattcccaaattaccatctaaaact
|
76441gtgtactagtttatagtctcaccaacagaggataaaaattcccatctacacccttctacc
|
76501aatatattttatcaatatataagatagaatatattattgttttaatttatatcttatttc
|
76561cagaaaagttaaacatctcctcacatatgcaactgttcattcttatttcttatgaaaggt
|
76621attaccattttgattttaaacatgagggttcagagatgctagagtgacacaaccagtaag
|
76681tccagacatcaaagctgtttttttaacaatttcccatcaaaactaggcctctttctgtca
|
76741agtgtaattccccctaccagcagccagcaaactatggcctataagttagcagcccatatt
|
76801ttgtaaatcaggttttactaaaacgtagccacgcccattcatttaagtattgtctatggc
|
76861tgcttttgttctccaatggcagaggtgagtagttacaaccacatggtctgcaaagcctaa
|
76921aatatttactactggggtctaaacagaaacaataacttgcctaagcacagtgactcacac
|
76981ctgtaatcccagtgctttgggaggctgaaggtggtggactgcttgctgtttgagcccagg
|
77041agttcgagaccaacctgggcaacatggcgagattccatctctacaaaaattagaaaaata
|
77101gccagttgtggtggcatgcacctgtaatcccagatactcaggaggctgaggtgggaggac
|
77161tgcttgagcctgggaggccaaggccgtggtgaactgccattgtgccaccacattccagcc
|
77221tggaagacagagtgagactccatgtcgaaaaaacaaaacgcacacacacaaaaaaaacaa
|
77281gagttaaaaactaaagaaaagctcaRgtctgggcacagtggctcatgcctgcaatcccag
|
77341tacttaggaaggcttagcgagaccccatctctacaaaaaataaaaaaaattaggctaggc
|
77401acggtagcccacacctgtaatcccagcattttgggaggccgaggcgggcggatcacgagg
|
77461tcaggagaatcgagactgtcctggccaacatggtgaaaccccatctctactaaaaataca
|
77521aaaattagctggccgtggtggcgtgtgcctgtaatcccagctactcaggaggctgaggca
|
77581ggagatcacttgaaccaaggagttggaggctgcagtgagccgagatcgtgccactgcact
|
77641ccagcctggcgacagagcaagactgtctaaaaaaatttaaaaaattaaaaattagccagg
|
77701cacagtgctgtgtgcctgtagttccagctacttgggaggctgaggcaggaggaccccttg
|
77761aaccaaggagttcgaggttgcagtgagctatgatcacaccacggcactccaaaatctggg
|
77821tgatagagcaagaccctgtctcaaaacaaaaaaagaaaagcttctcagtggggattagtt
|
77881atggtctaattggccacagccagagcatggctatgttacagtgtgtggctcattttcaaa
|
77941taactttatatgcagtataggtctggtatataatcccaaaggaaagagcccaaaacactc
|
78001aaatgaagtcaaaagacttatctttacttatgggttgcaacactaaaagattttctatgc
|
78061actactcttcgtcttccttgtttcttttctttttttttttttttttttttttgagacaga
|
78121gcctcattctgttgcccaggctggagtgcagcggtacaatcacagtttaccacagcctca
|
78181acctcccaggctcaagcgatcctccttcctcagactcctgagtagctgggaccacaggca
|
78241ggtaccaccacacctggctaatttttgtattttttgtagagacagggccttgtcatgttg
|
78301cctaagctcatctcaaactcctgggctcaagtaatcctgcctctgcctcccaaagtgctg
|
78361ggattataggcatgagccaccatgcctggccccttatttaatttcatctggttcctactg
|
78421tccttcaatgattttgacaatgtagttcctacccacacaccacaataatacaaaaccaaa
|
78481gcaaactccactatgtctgctgctaaacacccccaacaaacacacatacacatcacacca
|
78541caccacacaacacaacacaggtgtctccttcccttttgctagcagattcgctaggaagca
|
78601gctgcacatttccagcaagtcgaacaaactgctgagagctagggcccctgaccattgtgg
|
78661gaaaggaaggccaattctcccctctagattgtacccttctgaagatcctggccatgaaag
|
78721aagtcatttctccagagaattttaagccattcagttcctatacggcaggcaggaaaggtg
|
78781tcatcctccccatatcatcagtggaggaactcagtgtaacttgtttcatttcctcttact
|
78841tcaaaaSgtcattttaagtaatagggtcatttaggtaatatcagtgatctttttaatttc
|
78901tcctcgcattctctcccMaattttggttttacaaaataatggttaaaaaaaaaaagctat
|
78961catactctccacgaaatttaacttaatctagaattttgaatgagaaattaataatcaaag
|
79021aacagtgcattttaggccaggcgcggtggctcactcctgtaatcccagcactttgggagg
|
79081ccaaggcgagcagatcacctgaggtcaggagtttgaRaccagcctggccaacatggtgaa
|
79141accccatctctacttaaaatacaaaaaagtagctgggtgtggtggtacgcacctgtaatc
|
79201ccagctacttgggaggctgaggcaggagaatcgcttgaacctgggaggtggaggttgcag
|
79261tgagccgagatcgtgccattgcactccagactgggggacaagagtgagacttcgtctcaa
|
79321aaaacaaacaaagaacagtgcattttcttacacaaataagcaggtattaagtggttctct
|
79381ggataggaatttggcaatacaaatcaaaattaatgcctataatcctagcactttgggagg
|
79441ccaaggtgggcggatcacctgaggtcaagagtttgaaaccagcctgaccaacatggagaa
|
79501acccgtcttaaaaaaatacaaaattagctgggcgtggtggcacatgcctgtcatcctagc
|
79561tactcgggaggctgaggcaggagaatcacttgaacctggaacaggtggaggttgcagtga
|
79621gctgagattgtgccattgcactccagcctgggcaacaagagcgaaactccatctcaaaaa
|
79681caaaacaaaaccttgatatttgggccaggtgtggtggtggcacatgcccaaaatcccagc
|
79741actttgggaggctgaggtgaaaggattgcttgagcccaggagttcaagaccagcctgggc
|
79801aacatagtgaSacctcatctctacaaaaaataaaaaattagcYaggcatggtggtgcaca
|
79861cctgtggtcccagttactcgggaggctgatgtgagaggatcacttgaaccctgaaaggtt
|
79921gaggctgtggtgagctgtgatcataccactgcactctagcctgggtgacagagtgagacc
|
79981ctgtctcaaaacaaagaaacaaagaaacaaaaatgttcatatttggctgggtatggtggc
|
80041tcacacctgcactttgagaggccgaggcaggatgatctcttgaagtcaggagttcaagac
|
80101cagcaatcttctcgcctcagcctcccaaagtgctggtgctaggatgatgggtgtgagcca
|
80161ctgcacccagcctaagatagtaaattttgttacatacatcttaccaaaactcaaaaaaaa
|
80221aaaaaaaaaaaaaaagctggctgggtacaatggttgaagcctgtcatcccagcactttgg
|
80281gaggccaaggtaggaggattgcttgagcccaggagttcaagaccagcctgggcaacacag
|
80341tgagaccatgtctctacaaaaaatttaaaaattagccaggtgtggtggcatacacctata
|
80401gtcccagctactcaggaggctaaggtgggaggatcacttgagtctgaKcctgggaggctg
|
80461aagccataataagctgtgatcataccactgcactctagcctgggcaacagagtgagatct
|
80521tgtgtcaaaaaaaaaaaaaaaagaaacaaaaagaattaaaaaaaaaaaaatctcatgttc
|
80581tttcatcaaataattccaatcacagaaataaaagtttaggaaataatctgaaatacaaag
|
80641atatatggacattaatagaattatttatcattctgaaaaactgaaggaaaactaaatatc
|
80701taacaataacttaaattatggcaagaatatacatatgatgaaatcttatgcagtcactta
|
80761aaatgttttaaataagtttggctgggtacagtggctcacgtctataattccagcactttg
|
80821gaaggctgaggtgggatgattgcttaagcccaggagttcaagaccagcctgggcaacata
|
80881gtagactccacttctacaaaaaataaaaataaaaaaaatagctgggcatgatggcatgcg
|
80941cctgtagtYcagctacttgggaagctaaagcgggaagatcacttgagcccaggaggtcaa
|
81001ggctgcagtgagctaggattgcaactgtaccactgcactccagcctgagtgacagagcaa
|
81061ggccccgtctctggggaaaaaaaaaaaagttttaaataattttaatgacatggggaaata
|
81121ctcaagaaaKgttgaattttaaaagcaggatataggctgggtgcagtggcatatgcctgt
|
81181aatcccagccctttgggaggccaaggcaggtgaatcgcttgggctcaggagttcaagacc
|
81241agcctgggcaacatggtgaaaccctgcctctacaaaaaatacaaaaattagccgggcatg
|
81301gtggcatgcacctgtagtcctagctatttgggaggctgaggtaggaggattgcttgagcc
|
81361cagaaggttgaggctgcagtgagctgtgatcgtaccactgcactgaagcctgggtgagag
|
81421agtgagaccctgtctcaaaacaaacaaacaaNaaaaaggcaggataaaactattatggta
|
81481tggccccatttttgaaactatatatacaaatatttatagacagatagatatatcatatac
|
81541atatttatccctctccccacatacttgtgagtttgtatatgtgtatgtatacgtgtaagg
|
81601aagtataccaaataatgttcatttctgagttgtggaattatgggtgccttttactttccc
|
81661ccttaacacattatttttcatgttttctaaatagtaccatcatatacaattaggaaaaaa
|
81721ttactttcatattgtttaatctagtaatctatttgtagatatgtatcataagaaaataac
|
81781caaaaacgtagacaaaaacttatgcataataatgttcatataaagatacacagaaaacta
|
81841ttaataaataatggttacttctgcagggcagaattagggtaaagacttatttggggactt
|
81901atttgttatatctattacaaaaatgatttgaaaaaaattccattattatttgaaaaaacc
|
81961tgaaagcatataaaaatcctatatgatagactattatgcagccactacaaatatttatga
|
82021agagtatatataaatttatataatgaaaaaatggtaaatggggaaaaaagcagaatataa
|
82081aattttaggtaatatatgatctggaaattgcaaaaccagaaatatacaagcacaaaatac
|
82141tgaaagaaaataggctaaaataagaacagtagttttctccagatagtgggattacgggtg
|
82201atttcagttttcttccttatacttctctgcgtttttcacatatcctagaatgaatatata
|
82261ctatttttcaatcaggcttaaaaaatgtttttggtttctgccctataatgaaaagcctgc
|
82321tccttgtgtgaaattttatccacaaaggattatcagtagtaagcaacccactagcaagaa
|
82381gactgttcataatgtatatgcctaagaaaatcatctttggtgggtcagtgagctcagttt
|
82441aaagggacacagctctgaccacttcctgccttcttgcttttggagttgttttagtaaata
|
82501taactgaggaatcaagttctcaaacatgagatgcctgacaaacttaatactgtactgtaa
|
82561gaaccaggaccaccaccttctctcaacctaacctYtaagactttacacttaagaatagac
|
82621aagaccgggccgggcgtggtggctcatgcctgtaatcccagcactttgggaggccgaggt
|
82681gggcggattacctgaggtcaggagtttgagaccagcctgaccaacatggagaaaccccat
|
82741ctctactaaaaatacaaaaattagccgggcgtggtggcacatgcctgtattcccagctac
|
82801tcgggaggctgaggcaggagaatcgcttgaacccaggaggcgggggttgcggtgagccga
|
82861gatcacgcctatagcctgggcaacaagagcgaaactctgctcaagaaaaaaaaaaaaaaa
|
82921gaatagacaggacctaaataacatagattgggtcatgttagtctgtaaatcaaaaacact
|
82981taacagctaattacatgaagaataaaatccaaatttcttagcataacgcttaaggttctc
|
83041taagatccaaccctcaaatttccttcccagcctcatcttcagttcattccctaaaatatc
|
83101ctctacctcaggcacattttccccatacatgccaggcattttccaagctgtgtgcctttg
|
83161cccatggtgtgacctccattaaatgccctgtctcctaaacctactgaactcctattcttc
|
83221ctttacaacctggctcaaatgccttctcccaaactctccttatcgcccccaccatcagga
|
83281acaattgttctttcctctatgtgctcccatattgcttgttcctctacaaacttaattaca
|
83341atcctccctgggtggatgctagctgtaatacttgtttcattttactaaactcctggaggg
|
83401cagaaaccattttaaaatcatttccactccagcacactgcttgcacacagtaggtactaa
|
83461atatgctgcctgagtaaatgacagccaattggcccttatctgaattctttcagtggtaca
|
83521gccagggatggcaaattgtcaaagctagtccctctaattgcaagttatacatatagcatg
|
83581agtgaccagcagaaaatgccaagggcctgccactttaagaggactggcaagaYgactatg
|
83641tttacacaatcctaattaaaactaaagggcaatgagggaaagaagagaaatagggagatt
|
83701aagaggtgtggattctacaggtcacctcctcttcttagtgagcttgctaggcactaggct
|
83761ggaagatctgagctacaaagtagcctattttatctttggggtagcctgtaggatctaagt
|
83821attgaaaagcaactaattaggccactttgtcctccagcaactggccctgctcttgggcat
|
83881taacttccaactggtacacaaggctttttctctaaatgaatcccactgtaccaatcacta
|
83941ggagaatccctttaaaaaaggcttgaaattaataacagcaggaaacaaagtctctcaatc
|
84001ctctgaatcacaatatccacactgtccattttgatgaaattcacccccacctccttcaaa
|
84061caataggtcctaccaaggaatgacttctctcaggaccaacatgtcctgtgattgtttttc
|
84121tggagcaagcttccagtgcctgcttctcattaaatagctacttaatgtctgatcacccag
|
84181ctgtgactataagtagagagtaaagtaactataatttaggaRgtaaaaaagaaattccac
|
84241tcctaccccaagtccagtagtcaaacagcttagaatagacatttccctacctcaaacctt
|
84301cttaggcttatccaattttcagatctagaatttttagcatctcttaactctttcaatata
|
84361aaaatgaggaaaacaatRtYtagagtaagaaagagaattgcaaatgattatacagtaact
|
84421tagtcacagaatcttttgaccaggctgtctaacacctcatttaactgatgagttttcaag
|
84481accactgtttccaggaacaggttacagggcactacaatataatcagcttaatttgcatat
|
84541attcaagataacagcccctaggcttgaccccttcaccatcttcctgcctaccttttttca
|
84601aacccacaactgctaacaacaacaaaaaaatcaatgtagtgatttaatacatcatttctg
|
84661cctaaaaaaagactggagctaccaaaccatctgcttcagcctcaccacctgggattcatc
|
84721ttgattgatttgggtgtgttggtgggcagtggctgccacagcctgaagaactcttccaac
|
84781tctttctgggggtcttctggagatgggactgcaatggctcctcagctgcagtttcctata
|
84841gagcaacatgttgaaacacacttgttccctcaacacacttgtgtttcagccctcaacaca
|
84901cttgtgatttgggaggagtaccaggagaaagaccagtttttggcagggcgcggtggctca
|
84961cgcctgtaatcctagcactttgggcggccaaggcgggtggatcgcttgaggtcaggagtt
|
85021caagaccagcctgaccaacatggtgaaaccctgtctctactaaaaatacaaaaaattagc
|
85081tgggcatggtggcacatgcctgtaatcatagctactagggaggctgaggcaggagaatcg
|
85141cttgaacccgagaggtggaggttgcagtgagctgagatcccgccattgcactccagtctg
|
85201ggtgacagagagagaccctgtctggRaaaaaaaaagaaaagaaaggccagttttctccat
|
85261tatctagtcaccccaacctataagcaagcatatgcacagtcactataaaggaaagtgact
|
85321tgttttccagcagacatttctaatcttattaaatcaaatgaaaactgcaatcaaaatact
|
85381ctccttaggaagttatttacttattctaacaaaacacttctttgggagctgcctttaaag
|
85441tctactccatgtgagacaaacagaaaaattcggtgttactgttttatagtcacacctcat
|
85501ccttcaccaaaaaaggtattgccttgcatgaatctttggctcacggcatcttctggctgt
|
85561ttctaaaaattgaatccaccaagctaagagtaaagatttgctacctctgaggatattcaa
|
85621aagattggctcagaggcagtctgaggcaatgacaccatcaccaaaggaaatctaaaggct
|
85681gagaacacaattactttgaaggggtcaaacttaaaaacattctaattgccccataattac
|
85741aatcaagggggcaagacatgtacaatatctgtcacatttgttcaactattatatcacttt
|
85801ataattacacattaYataatgataaattttggccctggaagaaatcttcaagatcatata
|
85861atcctaactgtccctttttacatatgagaaaagttcagtccattgaggttaggcaatttg
|
85921tccctggtcacacatctggttagcaacagtcaggatgagaaacccagacacccaaactcc
|
85981cagcataatgcacccacacatacttatgtatacagctcctcctcccctgcttctcacttc
|
86041cttcactcccctgatcaaaagggacagaaataacttgggacactaaagcacaccaagaat
|
86101ggttctgaaacccagtagcagagaaatgatggcttaaaaaccaggacttctctgcagtgg
|
86161cctcaatggccaatgtttagtgtctggctcacaagagttctgggcaatctacctcagagc
|
86221aagggccaatgaaaacctctggacaccaccctcccacagttagaaaaatatctttattaa
|
86281acctctctgctctcctcctacagtaacctgtttgcctcaaataattgaaagacaaagaca
|
86341atcactttgaagaatctgggtcagggaaaaagtaaatggtagagatcctgctcaggacaa
|
86401agctgacctatSaaaaactagagggcagaaaccattttgacttacctcctggtggaagcc
|
86461tccacacactagaacagggtgatctccagcagtctggcttagaattagtttccacctagg
|
86521gaaggggcaaagggacaggaatgattattcattcccctaacccacccactcttagtgagc
|
86581tcagcctcacattatcctgggcaaccccagcgttctgtggatcagacagcaagcagaagg
|
86641gaagccatgcaggccaggtcaacggggtgagtcagtggcagagcaggaagagtcactggg
|
86701gcagaaattctggccttctgtggcaagactgccaagccacacccacacttggtcagcact
|
86761gtgaaggccctgccctgttaggatttcagtctttaagccagaaaRcttcttcctcaggag
|
86821gccccacaccactctcattttcaagtgtctctcctcctgctcaaaaatcttccagttttc
|
86881ttctccctaaagcatcatatctaaattctttggcttaactttccaaatcctccattatat
|
86941ggcctcaagtcatttattcaaccttatttcccactattctacagaatatactctgaattg
|
87001atcaagccagtcttcccacttctctctgcgtgagccaagccttttctcatttccctgctt
|
87061tcaattatccaggagtggtaaattcaaacatcttcaggggtcaggcaggtaacagaaaca
|
87121aattatccaggcaaggcccagtggctcacagcggtaatcccagcactttgggaagccaag
|
87181gtgggcagatcgcttgagctcaggagttccagaccaacctgggcaacatagtaaaactcc
|
87241gtctctacaaaaatacaaaaaattagcYaggtgtggtggagtgtgcctgggtcccaccca
|
87301cttgggaggctgcagtgagctgagaccgtgccactggactccagcctgggcaacagagcg
|
87361aaaccacgtatccaaacaaaacaaaatgaatgatccagtggggcacatggcagatctagg
|
87421aaacgctgcacccccctaaaggcattcaaatattttaattcaaatatttatgtagtgtct
|
87481cactgtgagcatcacgataaccttttaaatagttattaatactctatcttgcaaatgaga
|
87541aaacttccccaaggttaggtaactggcaaaatgctgggcacagtctctagacctgtctga
|
87601tgccaaagcaagagctctacaccattaggcttctagcagtgcaaacaccatggaagatac
|
87661agaaccctcaaagtcacttttcatgatacacaaccttaatagtaggatgggaagcccaaa
|
87721tcacagcttatctaaccatatcccaactgcctccaattctgttcattttccaaaccccat
|
87781ctttctgccaaagtatttcattcctagttatccaagtcctactgaattccttcttctgta
|
87841aattcctatagggtttatagattagacaacacaaataagtgctaaattatatactgtctt
|
87901gcaaaatcagatactgcttctatgtattttagtgtcagcctcatcaatcaaactattgta
|
87961ttaatctatatagttcttctaccaaaaatgcctaacctgaatctaatcaagaagaatcag
|
88021acaaatgctatgaaagacaaaaaggcattcagattaaaaaagaactgttcaaagttaaag
|
88081cagactaaagacatgatagtcatgacaactaagtgcataaatacatgcatgatccttcaa
|
88141tgaatcctgaattttaaaaaactcaataaaagacatcactgggaaaagatgagaaatctg
|
88201aacaagtattatatactggatgtattgaatcaatgttaagtttcctgagtgttaatagta
|
88261ctgtagttatataggaagatacctttttcttaggaaatacttgctgaaatagggattaaa
|
88321taacatgatatttacatctaacagtcaaaaagattcagaaaatgaaggaYaaatagacag
|
88381caaatttggcaaaatgttaatagtgactctaaatgagaagtatataagtatttgttacat
|
88441tattttgcaaaatatctataggtttgaaaattttcaaaataaaataatttagtaaggagg
|
88501gaaatcctgtattatatacttttttatatactcagctctgtgacagatataataggcact
|
88561cattactttaggtatctgctcactacctaaggaaactgggcatttggaggtcaRcaatca
|
88621gacagagtccactttgctgcagctcatgaggggtatagtaggaaattcttagggaataag
|
88681aggtttctccaaaactcacattgtcacaccacaggaaatctagaaaagcaggcaattacc
|
88741tcactcctcattgaggccatcacagaagtacaggcactgaacaaatgcccactcgctagg
|
88801cagaatgcagctgctgcccacacgttagtacccagtggtaaggtggatacaatgtgacct
|
88861cagaggaccaagagttgaggtcacattgcatccaccttgccaccgggtaccaaaaatttg
|
88921acaatctgcaaaacaagtgtctctggccagtcacaggaaggcactcaagtatcaaataaa
|
88981catgcctgaaatatatgcagtctttcctcctcaccagataaaccagtcctcagctgcaat
|
89041aaggcagaagaaatctgcaaggctgaatcactggtatttcctgtgcagacttcaaagaaa
|
89101ctggcccttcaataggacagaaagggcaggcgacacagctgccaacagaggcctcaaccc
|
89161aggagcatgctatgcaataatgccttctctcccttctacagccatcagatacctcatttt
|
89221taYttctgccaaatggccccttattaccgcgactgattacctaatagccaaccctttacc
|
89281ttggttctctcctcccctcaatgagacccaagatactggcctttctagacagctcctcct
|
89341ccaatttgccagaggaattgtcaaaactattcccctggccaggcRcggtggctcacgcct
|
89401gtaatcccagcactttgggaggccaaggcgggcggatcacactgtcaggagatagagacc
|
89461acggtgaaaccccgtctctactaaagatacaaaaaattaScYgggcgcggtggcgggtgc
|
89521ctgtagtcccagctactcgggaggggaggctgaggcaggagaatggcgtgaacctgggag
|
89581gcggagcttgcagtgagccgagatcgcgccactgcactcaagcctgggtgacacagagcg
|
89641agactccgtctcaaaaaaaaaaaaaaaaaaaagctgcctaggccaggcacaatggcttac
|
89701acccataaacctagcactttgcgaggccgaggcaggaggattgcttgagctcaggtgttc
|
89761aagactagcctgagcaacacagcaagaccttgtctctactaaaaatcaaaaaaattagcc
|
89821gggtgtagtcccagctacactacttaggaggctgaggtgggaagacagccactgcactcc
|
89881agcctgggtgacagagcgagaccctgtctcaaaaaaaaaaaaaaaaaaSttgcccacagt
|
89941aggaggtagaggagaggccattattaagcacactctcagtaaaccatgaatctgacagag
|
90001ctacccaaaacatcaatgcagtcttaagctgcattagtagaagatgactctatgccccac
|
90061ctttgaagagcaaagttagaggacttgcagaggaagaacaccaatgaccatggcaaaggg
|
90121tctagaagtatatcatttcaaatatggaggaagaactacacacttttagccaggggagaa
|
90181caagaaaacttttttcaaatatacgcatagctttcacatagatgaggagaaagacttatg
|
90241agtccactataagaatacaaaaccagaactaatgagtggaagttacaggaagactgattt
|
90301tggtttgccacagggaagaaatttcagcatgttgtagaagttcagaatgtgggatgtaga
|
90361acccagaatgcttggattaggatgtcaactccaccacttataaactgtgtggctttgggg
|
90421agattaatctacctgtgcctcagttgccttccctgtaaaagagaatagtaataatagaac
|
90481ttagctcacagagctttaagaagtagcttccgagRctggctgcggtggatcaggcctgta
|
90541atcccagcactttgggaggctgaggcaggtggatcacctgaggtcaggagttcaagacca
|
90601gactggccaacatggggaaacccgtctctactaaaaatacaaaaaaaattagctaggcKt
|
90661ggtggcgcatgcctgtaatcccagctactcaggaggataaggcaggagaatcgcttgaac
|
90721ccaggaggcagaggttgcagtgagccaagatcacgccattgcactccagcctgggcacca
|
90781ggagcgaaactccatctcaaaaaaaattaaccagacggtagtggtgtgcgcctgtaatcc
|
90841cagttactcgggaggctgaggcaggagaatcatttgaacctgggaggtggaagttgcagt
|
90901gagcagaaatcacMccactgtactccagtctgggtgatagagagaggctccatctcaaaa
|
90961aaaataaaaagaagtagtttctgtaaagtacttagaacagtgcctagttcacaatatacg
|
91021ctggaaaaaaaatgttacctattgctattactaaatgttgatacaacagaccaggctggg
|
91081tgtggtggtttgtgcttgtaatcccagcactttgagagaactgcttgagctcaagagttt
|
91141gagaccagcctgggcaacatagtgagacctcgtctctactaaaaataaaaagagttgcca
|
91201ggcacagtggcgtgcacttgtagttccagctactcagcaggctgaggtgggaggatagct
|
91261tgagtccaggagatcgaggctgcagtgagctatgatgacgccactgcactccagccagag
|
91321tgacagagcaagactctgtctcaaaataacaaacaggctgggtgcaatggctcacgcctg
|
91381taatcccagcactttgggaggctgaggcgggtggatcacctgaggtcaggagttcgagac
|
91441cagcctgggcaacatggtcaaaccctgtctctactaaaaatacaaaaattagctggttgc
|
91501agtggcacgtgcctgtaatcccagctacttgggaggctgagacaggagaatcacttgagc
|
91561ccgagaggcggaggttgcagtgagccaagactgYgcaattgcMctccagcctgggcgaca
|
91621gagtgagactccatctcaaaataaataaataaataaataaataaataaaataaaaataat
|
91681atacaatacaaaaaacagaccagataacctgaagcccttcctactaaatatgcctagaag
|
91741tgctcagaaaaatataataaacatccttYtagactgtgccagctattaaggtattgtctc
|
91801tcagctccaaatctaccctgttatgctccgctttgtgatgctggggcctggactccacta
|
91861aaccccatttcacatttgccagctggatccctgtcaacagggggtgctaaggggaaaaca
|
91921gaagacaagagaaggctacaagggacttcctccttcttgtagcctggtgtttcttgacaa
|
91981cagaagttggttcttcccagttgcYttctaaactcccaaaaccagcctcctgcccctcaa
|
92041aggcaccagcatcagctaagtaaggctcaacagaagccagctcctccaggttcctcctat
|
92101aagggcctgagaaaccagcagcaccaggtaacaccctctccagagaatctgggtacagct
|
92161attccagatccctctagacttctaggttctggtagccccaaccttcctccctttgttttt
|
92221cagtcctggatgagaaaaattctttatgcagttattatattgaagttactttaatattcc
|
92281ctttctgctttttcagccctccaccaagggtttaaatcaatctcctttatggagttcact
|
92341ctattgtgtggtttctgttttgctgattggatctgaactgacatatagataaactgagct
|
92401ctcaagaaagtaagaaaaatccccaggaaccagaaacaaattagtgaggaggattagcga
|
92461gctgatgacatagctgtcctagccgtgtatggaatttgtaacaccctcataggttcagaa
|
92521gacagatcttgagtccacaaaaggcactgagatccctgtgcagaggctgagattcttaag
|
92581tttatactcagtaagataatagactaggaaaaaaaatctgtccagagagaaataaaaaac
|
92641ttgccttgctcacctagtgagaaaggagggaaaaaccgtctaggaattcaaaacaggctg
|
92701ggtgaagtggctcacgccagtaatcccagcacattgggaggctgaggtgggtggattgct
|
92761tgagcccaggagttcgagaccagcccgggcaacatggcaaaaccctgtctctacagaaaa
|
92821tataaaaatttgccgggtatggtggtgtgcacctgtagtcccagctacttgggaggctga
|
92881ggtgggcggactgcttgagcccaggaggcagaggttgcagtgagccaagatcctgcaact
|
92941gcactccaacctgggcaacaaagccagacagatcctatctcaaaaaataaaataaaataa
|
93001aataaaattctaggaagcagacattaatatgtagtgaaaaacaaacaaacgatcagtggt
|
93061tcctggtatcagggtgaaaggaaaaacggactgtaaagaagtatgagagccgggcacggt
|
93121ggctcacgcctgtaatcccagcactttgggaggccgaggagggcagattacctgaggttg
|
93181gcagttcaagatcagcctgaccaacatggtgaaaccccatttctattaaaaatacaaaat
|
93241tagctgggcatggtggtgcatgcctgtaatcccagctactcaggaggctgaggcaggaga
|
93301atcgcttgaacccaggaggcagaggttgcagggaSccgagattgcaccactggactccag
|
93361cctggagaataagagtaaaatccatcttaaaaaaaaaaaagcatgagaaatcttttgggg
|
93421gtgagagaaatcctctgtatctKgattatggctgctgtttacaggtgtagacatctgcca
|
93481aaactcaactttcttgaaaattattacagacacaaaattgaaaacatgagacaaaaacaa
|
93541gatcacgaaaaacaagcagatttgaaaatgaaccaaagagcacttctaataaatgaaaaa
|
93601gttagctaataaaaataagaattcaaaaaacaaattagacctagctgaagagtaaactag
|
93661tatactagaagatagatataaggaaattatccagaagttaacacagaaagatagaaatgg
|
93721aaattatgaaagaaagaataagatgtagacRacagaatgaggaagttcaacataMgttac
|
93781gcatgagatctgagagaggtaaagaggtaatgattgggaatttttacacaattagtgaaa
|
93841agatatgaaatttcagattaaggaattactatatgcccccagtatatagtgatttaagaa
|
93901aattaaattcacaccatgtaatggaagtacagaacacaaatgacagcaaagaagatctta
|
93961aaaacaaacagaaagaaagacaggttacccacaataaaataagttaatttgcaagcatag
|
94021ttctcaagagtaacaacaaaaagccagaatttcaatgaaaaaacactttcaaagtgctaa
|
94081gagacaataattggaagcctagtacccagctaaactaccaatcaagactgaaagtgagct
|
94141gggcacagtggctcatgcctataatcccagcactctgagaggccgaggcgggaggatcac
|
94201aaggtcaggggatcgagaccatcatggctaacacaatgaaaccctgtctctactaaaaat
|
94261acaaaaaattagccaggcgtggttgcgggcgcctgtagtcccagctactcgggaggctga
|
94321ggcaggagaatggtgtgaacctgggaggcgKagcttgcagtgagccgagactgtgccact
|
94381gcactccagcctgggcaacagagtgagactccatctcaaaaaaaaaaaaaaaacaaaaaa
|
94441ctgaaagtgaaataaagattttttaaatgaagacagtgtttaccactaacagattcccac
|
94501tggacaaacatctgaaggatgtatgtatctatgcaataaaaaaggaaggaataaaatgca
|
94561aggaaaaatagtgaaaaagcaaacagtagacatacatgggtaaaatgaaataatcactaa
|
94621caatacaaaacaataaacatattttaattgtgttggggtctcactctgttgcccaggcta
|
94681gctaagaactcctgggctcaagccattctcccgcctgctcctcctgcctcagcctccaga
|
94741gtagttgggatgacagggcaagccaccatgcccagctacaaaataataattatcaattag
|
94801aattgttcaRcttagagatggattgactttgggaatgatctcattctagaaagtaYtcat
|
94861tttgagtctggacaacaccttttggtatgtttagtgtacactgggtaagaggctaaatta
|
94921aatgaccacaccatatattaggttaatgcaaaagtaactgtggtttttgccattactttc
|
94981aatggcaataactgcaattacttttgcacaaacctaatatcttctgatcatagttttatc
|
95041aattagacacagctgtccaaacagcccctgatcagctctgttcagccacctgagcagggc
|
95101tttgccctcatcctaaaagttctagaattcaagtcttatttcaaggcattcttcccactt
|
95161ccatgttccacatgtaaaaaagaattctacgtttcttaacgagctttcaggtaagatctt
|
95221taagcttttggaatgtaccgcttttcgctgtgaactaagagcttagacattacaattagt
|
95281catcccttgctagaacttaggctacgaaaagaatactttggaagctttcacaaaaaagta
|
95341tgtggttcttcctctaaagaagaaaataccacacagaaagagggactgaggaaacataaa
|
95401cccatctgtgctgacagaaagctaccttacatgatcctcatgttcgccccaggttcccat
|
95461atattcacagcagtaaagatctccacaaagcagagaggcccaactcccttaccattaaag
|
95521ctttaacgaccagacaacccagaagtttggaaacatagaaccaggcaacagatactagag
|
95581agagggaattatgtattaaagcaagaaaatatcatcacgttttcaagagggagtgccatt
|
95641ccagtaaagaggacagcttaatactgaggttcaaatgccactaaatgaaaacgggaaagc
|
95701gaaattcctgtgccctttcagcccaagaaattattccaaagcatacatttattcccatta
|
95761catgtcgcaaatcctgcctagccattaggatacagtgacgaaaaagtctctcgttatcta
|
95821gaagggcagacaaacacgcagacttttaaaataccagatggcaggccgggcgtgatggct
|
95881cacgcctgtaatNccaagcactttgggaagccgaggcgggcggatcacgaggtcaagagt
|
95941tcaagaccggcctggccaagatggtgaaaccctgtgtctactaaaaatacaaaagttagc
|
96001cgggtgtggtagcgggcgcctgtaatcccagctactcgggaggctgaggcagggaactgt
|
96061ttgaacccgggtggcagaggttgcagtgagccgagatcgcgccactgcactccggcctgg
|
96121gcgatagggcgagactccgtctcaaaaaaaaaaaaaaatgacaagtgctaactcagaggt
|
96181aagcaaaagagagtacccagaggcggcagcatcaacccagtgggctcccgcccacccaca
|
96241atcttcacacagtcacaccacttatagtcataaatttgtactctccgaggtgcgtgtatg
|
96301aaacatgttatctgtgagagtccatggatgaaaaacaaaaacaaacaaaaattaaaaaaa
|
96361aaaaaaaaaaagacttaacctgttttgaccaggacaaccaccccaggaagtaggtaaggc
|
96421aggtaaggtcattgtttacatatatgaaaagtgaggctcaaaatacactgaccagtccaa
|
96481gacaacgcgcgcccccacaMagcaccttccccgtccccatttatgcccaacccataaacc
|
96541caaagtagagccaacctcgcactggctacgtaacccgggccaagctaaacattataaacc
|
96601tcaggctccccatctttaaagtataacaggtggttagaagattaaaaagataaacatttg
|
96661gcaggtcattgtggacggtgtagctcagaaaatgctgactactgcactaccataactact
|
96721gctattgttaacgataaaaggcaaagactttccaggacccgacccctcgcttacaagcct
|
96781ttcgggaacttgccctatacccccgaccccagtcaccttcagatttaattccacagacac
|
96841gcccccaaacagaccctcccctttaaggcaccccccccccccccggctcctccctctcag
|
96901gcgcctctcctcacaaaccttacccccatagattctgccctttcggactcggttatggag
|
96961gaggccttccgctcgcagcggcctctccagcaccccttttaggcctgagcacccgcaggg
|
97021gtgcccaggccgcacgccaaacgcgggcccgcgccggttacctggctgcgcgctcccgct
|
97081ctgcctcgcgattctccggaatcgtacctcttcgtgggctcgcgccagcgctgtgagcgc
|
97141acaattagtttaaactatggccccgccccctcgcgctgccctctgattggcctctgtcgg
|
97201cggggcccgcttaaggacccgggaaaaggaagtttgagggccactgggaaagagaagggg
|
97261tatcaccgcttccggaccccggcctgtacttgaaggcaaagagaactacaaatcccagcg
|
97321tcacccgcggccttgaagccccgcccctgacaaactgaaggtcccggtaagcatcgcgtc
|
97381agtacttatggcgcctgccgggttgtggtgacgaaagcagttgccatggagttgctctga
|
97441gtaaccctgaggcagtgggacgccaagactggagaggaagcgactgcgggtgagtcgggc
|
97501gggaaaacaggaaacccgttctaggggacaagagatctatggagaagggaggggcactca
|
97561cagaacgactaagaaccttcctgctcSgggatctgagatttcccccaccgaccctcatca
|
97621cctttcacRgcgaacaagatacaacactcacatgggacagactgggcgagggggagcaga
|
97681gggagggataggcgttgagatataYatccatacagatttggggatgcttaagaaccaccc
|
97741ccagggccgggagcggtggctcacgcctgtaatcccaacactgggagaccaaggcgggcg
|
97801gaccacttaaggccaggagttcgagaccagcctgagaaacatggcgaaccctgtctctac
|
97861caaaaacataaaaaaattagccgggcttggtggcgcgctccagtggccccagctactagg
|
97921gaggctgaggtagaaggatcgcttgagcccggagattgaagctgcaRtgagccgtgatca
|
97981cgcaactacactccagcctgggctatagagcgatacctccatctcaaaacaaaacaaaac
|
98041gaaacaaaacaaaaacaaaacaaaacaacgaaccccgcccccaacgcaaacataaagctc
|
98101ccaaaatcggatgcttcaagttccaRgcataacctgggagatcagaaacgccctcagaaa
|
98161tggggttggttttcctctgaggaactgagaccctcttccaagacatgcggttagcattag
|
98221attgagtaaatcgcagtcgctaccctaattctagagatgtaggaaacttcctggggcgtg
|
98281aagtgcctcattccttcttcttccaaggagtaaaaccccttctcaatctgtccccagatt
|
98341cccttttctccccacaccttctccgtggtccgctactcaaagctctacagttagagcttc
|
98401attttttttagtactcacgacRgatctattacatttagtaacctacccagtgctttcaca
|
98461gtctctcttttgatactcttaacagctctgtgagtcaaggatatttatcttcatttcaca
|
98521gattggaaaactgaaacccagagaaaagggacttgcccaaggccacacaccaaattagtg
|
98581acagagctagaactagactccagttctccgacttccagctaagtctctttagcttcagcc
|
98641tactgcctctatagcggaaggacttgttccaaggaacaagttaaactgccccagggaaaa
|
98701ggaacctgtgtggcctactttgtattatttacacttcagctggaatgaatttcagatcct
|
98761cccctgaaaSttttaatggggaaaaggaactagagagactaagacaatgagacttgaaca
|
98821tttttaactaaacaggaaacagaagggctaacacagcacccatgtctgaagtgaccatga
|
98881ttagctggtttctagctggtgactagctggccctgactggtccacttactaccttaaagt
|
98941tctcccaggtttggtcctacgccctcttgccactgcactctatattctcttcttgggtac
|
99001ccctccacacccacaacttcattttccacctgtatgcaaatgtacacaagtgtgtatctc
|
99061aagcccagccctcatctctaagctccagatctatatagccaattgcctcaacatctcctt
|
99121taggatacctcaaaggcaacccaaactctacatttctgaaattgaaacaatctctgtgta
|
99181tcccaaccttttcctccaagcctggatctcttccagtgctcctacctttatccacaatat
|
99241acccaagcccaaaacccaagttagtacctcttccatttacttaatacctcttccatttcc
|
99301catctatcactaagtcttatcagctttacttcctgaatatcttttatataggtcctagct
|
99361accatcacatccttcctgccttccctcccagccatatttgcgcactgcaaccagagtgat
|
99421ccttcaaaatgcaaagctgatactRttcactctctaccccacccccMatttttttttttt
|
99481ctttttgagacagagtttcgctcttgctgcccaggctggagtgcaatggcgcaatctcgg
|
99541ctcacagcaacctccacctcccggtttcaagcaattctcctgtctcagcctcccaggtaa
|
99601ctgggattacaggcatgcgccaccacacccggctaattttatatttttagtagagacggg
|
99661gtttctccatgttggtcaggctggtctcgaactcccgacctcaggtgatctgcccacctt
|
99721ggcctcccaaagtgctgagattacaggcgtgagccgccacgcccagccagcccccattta
|
99781atattaatactatgtggtttcctattgctcccatctctccagcctccagtctaaccatac
|
99841atattcatccttctctccccttcagttatataacctttaaggtcttcaaaatttccaagt
|
99901acccttccaccatagaacctttgcatatagcagtcacatctgcctggaatgctcattcca
|
99961caccaccccctaccccataagttaatttgtacttatcctttagatttctctcagtcactt
|
100021cttcaggaatgtcttcctgtagactgttcagaccaggtcagatccctcaattacagcaac
|
100081ctcatggccctctcctttgtagtRttatttagttgcaattWttaatgtgtttgttaagca
|
100141cctactacttgccggcactatgagatacaactgtaagaaaaaatatggtttctgccctgc
|
100201tggtgtttatggacatacagatagtaagcagataattaYagtgttacgagtgctaccatg
|
100261gcaatcatagcactacaattacagatttgaggataaaggtagacttctcagaaaagttga
|
100321aacctgatctgagccctgaaataagaattagcaaagcaaaaggaggagagaaaaactata
|
100381ttccaagcagacagagctggaaggagacactgttccacttagaggcccagtggcaggtgc
|
100441agggaacttatggtgagtggttgcatttggctagactgcagaattggagttgaggatgag
|
100501atggtagtagaKgggggtggacaggagccaggttgaatcttggtcctccttttggcacct
|
100561gggaatataacctcccagaatatattagattatgtggcagatttttcttctttttctttt
|
100621gacagggtctcgctctgttgcccagactggagtgcagtggcacagtcatagctcactgca
|
100681gcctcgaactcctgggcttgagccatactcctacctcagcttcccaagtagctgggacta
|
100741taggcgtgagctgccatgcctggctaaatatgtggcagatttttcatagcagcctttgat
|
100801tttttttccaccatcagtccatcatcagaaactctcgggccaggctgttgaatctcctat
|
100861cagatttatgtgattattcctcaaagcttcctgtgttatcatgttgcaacttgcctgaga
|
100921gagggcaggaataggctagcaacaaatcaaattccaaatgttagtaatttcccaaaactg
|
100981aaaacagttttctgtcaacttgggattggttaaataaattaagtgaataacattaaagta
|
101041cgataYatagtataaaatactttgcaactattaaaaagggtaatagtctacaacaatttg
|
101101aaaattaaaaaataggtttacaaaggaatattgtttatttaaaaatatacataatctagg
|
101161ctgggcacagtggcttacacctgtaatcccagcactttgggaggccaaggtgagtgaata
|
101221gcttgagcccaggagtttgagaccagcctaagcaacatggcaaaacYgtgtctctacaaa
|
101281aaatacaaaaattagcagggtgtggtgacgtgtgcctgtagtcccagctactcaggaagc
|
101341taaggtggtgggattgcctcagcccaggaggcagaggttgcagtgagctgaggtagcacc
|
101401attgcactccagcctgcacaacagagcgagaccttgtctcaaaaaaaaaaaaaaaaaaga
|
101461aaaccgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaaaaccttatt
|
101521agctatacattctaggttatattcccaaactgttaatggagattcaaactttgagtttct
|
101581atttgatgtacttcttgtcatttcactttattcatctatcatattagcttttacagttaa
|
101641aaaacaaaacagttaaagatactgtcaatttggaaatgagaaattccagttccgaaacaa
|
101701ggcaggtatgcccctaaccctgtcattcatcaagttagtcagtctggacagatgaaggtg
|
101761ctggcatctgattacctcctggtcataagccagaatagcagatgggaaagactgactcca
|
101821aaaacacagccacaggagtaagcatggcagcatcaacactttgtcagttctccccagcag
|
101881tcaagctctctatgtgacaccttgaagactccattaattccttcatttcttctttcattt
|
101941ttccattgtccatccattttcatttgtccatcaaacctttagtgaatatggatttttttt
|
102001ttttttttggccaggctcaatgcagggtaatgatgagaagggagaaagaagtctgagtct
|
102061tgtccctgtcctcaagcttatagggagtaaacaaagttggttataatgaaattaacagag
|
102121aatacaactgcttccatttattgagcacctgatgccagatgtacaatagttctcaaggta
|
102181gggtttgtctccatttcacagatgagtaaacaagctgtaataaaattttgtttgaagtac
|
102241agtgggggcatgcagaagttagctattgccgtgtaataaaccatcccaaaacacagtggc
|
102301ttaagataataaacatttattattgcttctaagtcttagagtcagctggagggttcttct
|
102361gctttggctgggcttactcatgtgtcggcagtcatctgtgggttgggtgactctcctgat
|
102421cttgactgggggtaggctgactgtgggctagtctaggatggcttcagctggtatctctgg
|
102481ctctttYgcatgtctctcacctacacatctcataaccctccagctgatcagccatgttct
|
102541catggcactggcaaagagcaagagggcaggcctcctttaaagcttctgtttgcttcatgt
|
102601ttatcgacatctcattggctaaaacaagtcacatgtctggtcccagcatcagagtgagat
|
102661gggactacaatgttataggcaaaaagagatggatacaggggagaccatgaatagggatca
|
102721tcaaaacaatcagcctaacacaggacacattaaccaattttatctggaaaagaaaggctt
|
102781tatagaagaggctacactagaactgagtgttgaaacatgagagagtattcactaagtggg
|
102841cagctgttacttggaactggatgcaggctggtttaccacaatcaatagaaactcagcagg
|
102901tctttctgtgctcatgacagggttctattatttgtatcttggcttcatttcttctggtca
|
102961ggcacagagcagcaagcacWcaacaaatgtttgctgaattgaattgaatatcttactgtg
|
103021aacaaggtgtggactgaaacagctgaacctgggaaccaattgttagaaagaacagcttag
|
103081catcaactcttctgaaacagaaatcctcagaattggcagtttctcattcattcatcccac
|
103141aaacattttgagtgcctgttgtaaacctggttctatgttggataatgaataagatgcgat
|
103201actagctcacagcctgggctacagcttaaatgcagaaggctaaaaatttaaccagcttct
|
103261tggggctccatttttaatactaatYcattcagaaaatgcaacaggagctggtgctacaca
|
103321aaatcagaagtctttaggaactgcactgggttgctctgNcaagaaaactaacagtaaaaa
|
103381tctgcccttaagtattttaagttaaaatccatgttcagtggtgcataactctggggtacc
|
103441aacccagtatttactttgagaaaagtatccaatcttgctcaaaggtatcaaatctgYtgt
|
103501aggtgctgaagtgggatgagcttctRtctaagctaggttcctctagttctgtagtagaca
|
103561gccaggttcctctatttttacaaaagaataatgtgttctttgttgtctgcctgtagattt
|
103621aatatctaaaagattcaagtctccctaattgacaatccatgcccatgggaccagttcata
|
103681acagaattaagctgtgaagtgactcaatctgtcacctccccaaagctcagctggtactgc
|
103741tattttttcagaacaagacattcattttcctctaaacctactaaacttgatccatgtata
|
103801tgttaaattgccaaaaaaggaatttacatgaactgtattaggcttaaactgaattataag
|
103861atatcaggtccttggtttttaacagaaattcttttttttttttttttttttttttttttc
|
103921ctgagacagggtctacagggtcttgctctgtcgcccaggctggagtgcagtggcacaatt
|
103981atagctcactgcaacctccaacttctaggctcaagcaatccaactgcctcagcctcccga
|
104041gtaataaattccattttaaagttgtttgccaatttcattgtctctgcaaactaatttatc
|
104101ctttgaatccaatgatgagaactgcaatcccaaggtttctctttttgctttggctgccag
|
104161gaatttcagagctaaatgtaggcttagattcttaaagtgcctggcacatctctctcttcc
|
104221tgtaatctagtttctgatctttctcttccatttttaactttctaatctgcactgtccagt
|
104281atggtagccactagtcacgtacatttgacaggtaggctagtccaaattgggatgtgctgt
|
104341aagtgtaaaatatctcagtaagttttaatattgattacatattgaatgattttttgatat
|
104401attgggtaaaattaagttattaaaattaatttcaccacttcattttacttattttggcta
|
104461ctagaaaattttaaattatatatatggcttgcatttgtgacattatatttctagtggatg
|
104521gcactattctgcaaatcatctgttttatgactgtgttattattgtaaacctgaaatcctt
|
104581ttggaaagcaggtgaagtaatacaaataataatacaaaggtggcagcagtggatggaatg
|
104641agaaaggggaggtcgactgggRcaagttcttgtccttatccttgtcaatttgtcttttgc
|
104701ttgtgtgattcacatacaaaccccttggtaaagtgtgttgtcagctctcttcatcccagg
|
104761tgagtagtattctcatggctctcccttgtctccagaaaaacctcagctttactttagcta
|
104821acaaattggaaacgatctgataagacaattcacaccacattgcaagtgactgataacaac
|
104881attgtgttcatccctgtcagggagtatttccattttaaccggaaacaatccctgaaccca
|
104941caggaatgaatgcctaatggtggagtttcagccatcagtgacaggtgagtgagaggtaga
|
105001ctctggttttgtgtgtgtgtatgtttatatgtgtatggctacattcaggatagggctgaa
|
105061agtagggtatttggatggaaaggtaatggggctggcagagaagccaagcggagaaggtgg
|
105121caaatccccagctgggccagactgagaggggtggtgagacaccaaccagatgcggtgcag
|
105181gccctcaaggatttgttaagcaatagaatagcccagttgatgtcaMcagagggtgggtat
|
105241caagacagtctccacagtaactactgtagagtaacagaaaaggtctcagagtaggattca
|
105301ggagattatgactgcagtctacaactgactcactggcttaactctgggcaagtcctttta
|
105361ccccttgggtttcagtttcttcatctggcattttccagacaaagaaatgggtgttcgatt
|
105421ctcaaatgagttctaagagatgtgaaggtgctctgagaagtagaaagtgctctatacatg
|
105481caaggatgcaaggaagagtgatttcatatcttaaaatggaaatacagccaggcaggccta
|
105541gagtagtagaggacagaaagcagggatggaggactatggggaaacctgaaagccggtgta
|
105601cttgaaacactggtctttctctgtcctcccaggctgaacccagactcccagggcacctgc
|
105661ttgcacctttgaatgatggcctgaactatgaacaaacgggactatatgaacacttcggta
|
105721caggagccccctcttgactactccttcagaagcatccacgtcattcaaggtcagccccca
|
105781gagcacagtactccactcactaaggcagcaggcccagtgtggtccctaggaagaaaccat
|
105841aatctacttaaaagcctaaagagattcttcccatatgcttgcagatgtgttgttactgtc
|
105901ttttggagggtaggggagagtgagaggtttttttctgtctttttgtttgWtttgattttg
|
105961ccccgatacagccccaggagatcctaagaacatgtgcccctgtttgttttttttaagcag
|
106021caaatctgaaaggaaacagggggctatcacagtagttgatcatctttaaaagaagccagg
|
106081ctacagcaggaaagtcaagtggaagaaaactgggaagccagtctatcagccaatagtttt
|
106141attctcctgtttttacctgaagagaggaggaaaacacaggctcctgtggagtcccagcaa
|
106201gtaggcaaaacctttctcctctgtctgcagacacaagcctaatctgactggccaaacatg
|
106261aggggtcttatctacaaactggcatatttccagtttaaatacttactgacaaatttctta
|
106321cactcattccagccaaatccaagtttattccatcatcacctacacttattgcaggttcca
|
106381acactgtccacactcgctcccattttgccattcaatgtctttgtaaatgggtagctagtc
|
106441ccttcaggagggaacatagggaggctgtcagccatgtcatattcccaatgagtcatccgt
|
106501tcttcctagggaagttctgccatccctggcttttgttatctggtctttcattaaagcatc
|
106561agtccatctgtcctcacagaatacacgttaacatccactatctcagaactattatttggc
|
106621tttagtcttctctcaggcaactggtagccactgcctttaagctcgggaagctggcaaata
|
106681gcaccagtcttagattgggtttagggtctacttgggttatcatcagccacagtggtaact
|
106741cacgtttgttctctcacgagcacacagccacctgctgtgatctttattgtgcactgcatc
|
106801acttctgatgtaatccatgtttcacaaggggttttagctgcaatagtaactatctctaag
|
106861acaggtgcaatgacagaggtgggaaggaagtatacctcctacctatcatgggaatttcta
|
106921actctgatggaggaggtgtagctctgccctctatggagtcctcagaattgggagagagac
|
106981aagcagtaccaagggtaactctacatcacaaaacgtaaatggtacagatggcccatcctt
|
107041cattcaaccgttcaatatttactgagcacttactaaaagcatttatatatgtgtgtgtgt
|
107101gtgtgcgtcatatgtatatgccaggtattgtgctccttgctaggtatgtgaggcacatca
|
107161aaggcccaaaaggtcagagtcccttcagattccccagagcttctgaaacacttatttaca
|
107221gctggggttaagggatacaatagagtttgggggtacctggcacactatttggtgaatgaa
|
107281taaatattacagaatctgaaacggcagtgcctttggaaggcatctaatctgtgctaccat
|
107341caacccagttcctctaacttttcacaaacctagagtgttaaggaagtcccccaccatata
|
107401cacctaccaacaccttccagttggtggttgagggatgacacagggaagttcaatcaaact
|
107461aacttgtattctgacacatggcaagagctacatggcagcctttcagagagaggaaaacag
|
107521gaacatagtttcccagatcttcctggagctaaatgctccccagttcccaaagcattgata
|
107581tttgtggtccagcttccagacctgctttggcctactctgaacaaggaactttacagattc
|
107641ttaggcagtgtagtgcattggtggaatctgagaggagcagcaacctgtggcagcctggat
|
107701ataccactccatccttgRtaagagcagctccagccagcatcaagttttaggcaactctgt
|
107761cccaccagtgattccctctgagcttggcctccaccccatgcttggtggcattccccaagc
|
107821tgctaccttatcacatggggcactagttcatgtggggttattttgaccttaattttgatt
|
107881catctgtgtcattctgtttcagggttctMaggaggtRtggggagggaagcaggattagga
|
107941attcatgagctggggtacgccgttccagtaccctcctgcaaccccaggccccaattgtgg
|
108001gtcctgctcactctaggattaaggcagagagccatctggtggatgttgcctgacctgcat
|
108061ctgaggaggaggagaggtgggggtggaagggcaaagggtgtccttccagtagagagcaga
|
108121agagagtgaagaaagctggctagcttccgcaaatactaaatacttccttccccaggggtg
|
108181aactagggaaccaaaggcttagcagcaatgggaactggacctcattttgaaaaagtggga
|
108241gtgaggctttggggtgttccatacaccggggttctaacataatcctattccctattctct
|
108301ctcctcctcagccaaactttctgaggatgttgtttatgctaactgcttatatccattcac
|
108361tctttttttggtagagacggggtttcatgatgttgcccaggctggtctcaaacgcctagg
|
108421ctcaagcaatcctcctgtcttggcctcccaaagtgctgggattacaggcatgaaaccagc
|
108481ctccattcactcttgaactcactcacttcMatctggcttctgcctccaggcccttgccat
|
108541tccactgaagcagcccttaccaaggttaccagggacttctaagttgccaaaattactttt
|
108601cagtccttacctccctggaacttactactataaactatttactccctgaacatctttaaa
|
108661ctgtcctctcctgattttccctgatcatttaacttctctaatggattcttcttcctccct
|
108721gaccttcctccctaccctcactctccctgaggaatctcatctctttccctaacttgtatg
|
108781ccttctatgctaatgattctcaagtctgtgtctcctgagcttccgaccttcatctccaac
|
108841tgcctacttgacttctccacctttttgtacaggaacctcaaatacaccaaagctaagcct
|
108901gaactcatcacattcccaatgctatttcttcttctgtaattccttaccagttaatacaac
|
108961tggcaaccaccctttaatattcttctacctttacatccagtcaaccaaattatgttgatt
|
109021gtagggccctctcatgtcttgcttggatgactcaaacagccaaattggtcatttggtcca
|
109081actcactccctaaaatccatattccacactgacacttaagagtgatctttctgaaataaa
|
109141agatttgaatcatttgctttaaacactccagtgccttcccattacacacagggtaaagcc
|
109201caagatccttagcctgacatttgagacttttgactggattcctgcctccttttcctctct
|
109261gtcccccttgtgcagtgcgtgcaagcacttgtgcaggcacacaaacccgccccagactcc
|
109321ctggctgttctgtacctctatacctttcttcatgctgttccctgcctgtttacccttctt
|
109381tgcctgataaacatcccctaatccatggagattcagctcaggcttcaccttccctgggaa
|
109441acttccctgagctcccatactgggtcaatagcctctcttctgtgctgctacaactattat
|
109501atagcacttatcacaccatRttgccagcttgctcccatcttgcccatataagctcctcca
|
109561aggcacaaatgtctgctctctgccctattattcatacaaagtctggaacagactgtctct
|
109621cattttgtttatcactgtatatccagtacctggcatactgtaggtactcaacattMatgg
|
109681aaagagagacaggatatcaaagtgtattccaYtgaagtgaattctataggctttaccagt
|
109741agttaattcaggattttgtgctatcatctactcagctcaagcccaacaattctggttctt
|
109801agttttcctcaaccccacactggtttggtataaaaaagacccagtggtacagtggacatg
|
109861agaagtccatgtgacctggaaagccaagagcttgagatagaagtctctggcccttagtct
|
109921aaacttactgattgctggaagctgtgggacagggttgcactagactcaggcacagggcta
|
109981tggcccttccagaccctccagctacagcctggatggctaatctttccagctctgtccctt
|
110041cccaccccctaaagccaaaaaagcaaagatRatacccaagtctcactttgtccccacaga
|
110101tctggtaaatgaggagccaaggacaggactacgaccactgaagcgttcaaagtcggggaa
|
110161atcactgacccagtccctgtggctgaataacaatgttctcaatgatctgagagacttcaa
|
110221ccaggtggcttcacagctgttggagcacccagagaacctggcctggatcgacctgtcctt
|
110281taatgacctgacttccattgaccctgtgagttcctaacagtaggaatccagtcaggggag
|
110341cctgaagccactttgttcagcccccaacctctccactcctacatgttatcaaggaagtaa
|
110401tgaggcagcatggtacagtccaaagcacaaggctagggggccagacagatagatgtaggt
|
110461tcaaatcctgggtttgcctcttactgactgtgactttgagcaagctacctaacctctcaa
|
110521aactgcagcctccctgtcggaaaaatggggataatatgccagtatcataaaggttttgtg
|
110581aggattgaatgaaaatacatgaaaaccacYgggcacagcggctcacgcctgtaatcccag
|
110641cactttgggaggccgaggtgggtggatcacaaggtcaagagagatcaagaccatcctggc
|
110701caacatggtgaaaccccgcctctactaaaaatacaaaaaattagctgggcgtggtgRYgg
|
110761gcgcctgtagtcccagctactcgggaggctgaggcaggagaatcacttgaacccaggagg
|
110821cagaggttgcagtgagccgagattgcgccactgtactccagcctggcaacagagtgagac
|
110881tccgtctcaaaaaaaaaaaaaaagaaaagaaaatacatgaaaMccaacaaacaactggta
|
110941catcagaggctgaagtaaaattStaactgtcactgcgcacccactgtgacctgtgctggg
|
111001ttctcctgtggaagaggtagtcaataaagtacagcacttactttctgtgaactcagattc
|
111061aagttttaagaaataaagtttggccttttctagtccaagatccctaagaggggaaaggag
|
111121ctggagcatgacttggacactattcccctggtgtggtgatctcaatttaaccagtatttt
|
111181aaaagcttcttatgtgcctagcatgatgctctgtcttcctgttgcttgctgtgatagaat
|
111241cgtaKatcaccaaagctggaaaggtcttcagtgaaggggcaactaaggctgagagaggca
|
111301agtcagtggcagtgctggtacccaggcccacactcctgaccctcagatcacagctccttt
|
111361tcagtgtgatgccctgtatgtcttaaaacataaataaaagtaggttacagtcatacagta
|
111421tggctgtggagggttgRagtggagggcaggttgttccccacattcttccttctctgccca
|
111481cgagtcagccctgagcagagattcagggtcctgtcctgtctagcctggcttttggtttcc
|
111541ctccccaacaggtcctaacaactttcttcaacctgagtgtcctctatcttcacggcaaca
|
111601gcatccagcgcctgggggaggtgaataagctggctgtccttcctcggctccgtagcctga
|
111661cactccatgggaaccccatggaggaagagaaagggtataggtaagtgccctgcccctgga
|
111721ggtagcgtctagctgggctcccctaaaggaaaggaggaggagaaacaagaaatctacgac
|
111781cattcttctgccatgcttggacctgggaagggagtaacagacctctaagcattccttgct
|
111841ctcagtcaggataaacctaatctttcccaaactatgctcaagtccctccattccttgcag
|
111901tcagggaagacaacagcaactagtggagggggaaggggattctggtgggggtgctggccc
|
111961ccagcctaagtcttccccacaggcaatatgtgctgtgcaccctgtcccgtatcaccacgt
|
112021tcgacttcagtggggtcaccaaagcagaccgcaccacagctgaagtctggaaacgcatga
|
112081acatcaagcccaagaaggcctggaccaagcagaatacactttgaggctcccacgacccta
|
112141gtagtcctaaaggcctaagcatagacagcatggKttgacaataaataatttgagctgttg
|
112201agcagatgagaagtcacttacaccttgtagagatgttctctaactcaggcaactgcaagt
|
112261agctctagccttttcttttcttttttttttttttgagacggagtctcactctgtcacaca
|
112321ggctggagtgcagtggcacgatcttggctcactgcaacctcagcctcccaggttcaagag
|
112381attctcctgcctcagcctccccagtagctgtgattaaaggcgcctgccaccatgactggc
|
112441taattttgttgttgttgttgttgttttgagacggtttcactcgtcaccccagctggagtg
|
112501cagtggtgcgatctcagctcactgcaacctccgcctgctgggttcaagcgattctcctgc
|
112561ctcagcctcctgagtagctgggattacaggcgcctgctaccacatccagctaattttttt
|
112621ttttgagacggagtctcgctctgtcRcccaggctggagtgcagtggcacgatctcggctc
|
112681actgcaaactccgccttccaggttcacgccattctcctgcctcagcctcccaagtagctg
|
112741ggactataggcacctactaccacgcctggctaattttttgtatKtttagtagagacgggg
|
112801tttcaccatgttagccaggatggtctccatctcctgaccttgtgatccacccacctcggc
|
112861ttcccccagctaattttttatattttagtagagacaaggtttcgccatgttggccaggct
|
112921ggtcttgaactcctgacctcaggtgatccgtctgctttggcctcccaaagtgctgggatt
|
112981agaagcgtgagccaccacgcccagcctttttttgtatttttagtagagatggggtttcgc
|
113041catgttggccaggctggtctcaaactcctgacctcaggtgatctgcccacctcagcctcc
|
113101caaagtgctaggattacaggataagccactgcacctggccagctctagtcttattttgct
|
113161gaaaaagggaggcaattgagggaaaggcctgctggcctgggacactggagacgtgggttt
|
113221accacacagccttgggaaatttatctaactctctgggcccctttgtacttttcaRcttag
|
113281agatttgggggttaaagtagatcagtaatttccaaactcttcacagagtaccagggtctg
|
113341tagagatgcctcacaggcctccatgacaggccaagaagatggcctatgatctctgaaacc
|
113401agcccccacttcaatcagatcaaagtaattccattctgttttatatgctgggattctgct
|
113461taagatttcatttgataaaaagaatcttctgcttaaaaacatttgcttgctgactccata
|
113521ttaggtattcccagaagagcctggtctgctttctctctccaccccccaacccgccatgtc
|
113581tcccttcacccccaggggctgttggtaattccaYtgagtctgaggcagggcccccaagaa
|
113641tcaaagctgcctcagattcaggtctgttcagctttgacagtgttcccatcatcactggac
|
113701aagggacaagaacagtctcatccagtctgaggttagcccaagccaggtctcagctaagag
|
113761ctgacaccctaaacccttgtctcttgggttcatcttcaatatccctggaagatgtcccct
|
113821tccccccatcttactctcatagacctaagtaatcaaaagtagaatgggtagaacagaggg
|
113881gccagaaccagcacatggatgaatatacttcctttatcgagggtgacaaaccaaaacaaa
|
113941aaaagaccaaacatgtaaaaacccMgggttctagaaatacaaactcaattcattcaaatt
|
114001caagctcatccagaccctggtcacaaaccctagtgaggtgcatgtgagcaccaagtcagg
|
114061gagagggggcaggagtgactctgaggccaacagaRagggtgggaaggggatctccctagg
|
114121tcccYtggtgatcaccccccacccaaactggtatctccacattctcaatgactatgaaga
|
114181cataccaggctctgtccttttggcccccacccYatccctggccagagcttcaaaggccag
|
114241tcccaaaaggttctaccctcacttgctcaggcttctaRccttcctcttctcctccttctt
|
114301cacatttttctctgtgattaStagcaggttagggtactgtataagccgcagtgaggctgg
|
114361gggccaagggggtggggtagagatgggatgaagagaggagaagagctgtccaaggacccc
|
114421tctcttcatgggatcccaaactgtacaaccagctcctcttttgcRtccacacggatctga
|
114481gaaagtgcactgtaggcataagcagctatcctggagacctgagacagagaggggccgggg
|
114541aggagaggaacagagacaggtgaggagggcaatcaggaaaaatggggaggggagattaga
|
114601tggtgatggagaaggagggaatgaaggggaacaggaaggcaaagagaaagacagggatgg
|
114661gagagacagaaggaaaagaacaaaggggagtgaaacaataaaggttgcaggaaggagata
|
114721ggaaagacataaaaagttaagagaacgaggtgggagggagctggggcctacaaggctacc
|
114781aggctccctaactccaccttccctacctcctctgaggcagagtgggtgaaccctctgcca
|
114841taccctgggcagtgtgagaagggtgggcaggggcaggtgaggggtgtctcacctgctgca
|
114901aatcagagaacgggatgggctcactggccagcacttggtggggctggctggtaagagacg
|
114961gcagcggtggcagcttcttccaatgggtcaggctgctgctcagcacagccaagcgggtgc
|
115021tgaccaagagagagggggtgggggtaggcagttaagcYacagtctgccctgcccagccca
|
115081ggtaagcctcatcccctcaggccagagaagcagggtgtcgaggaggggtatctgggaggg
|
115141aaggtctcagctcatcacagactcaatctaggcccatctcccttggcctcagYgccctca
|
115201agagtgtcacagggtaaacagggctgacatgaataactactgaagcacccaagtgatctg
|
115261tggtcagtctccagggctgcaccaaatgagaagcttggactaggggccaggctccaaagc
|
115321tggaacagtgatggagggtgggagcccaagtagcctgagggacccacgctggccaggtgc
|
115381tcacctgtactgcctggcacggtccatgtactcatgctgctccatgccctgtRagtctgc
|
115441agcagacacatcaatgatgttgctatggggagaggagacagagatgacatgacaggtgct
|
115501tccgagaaggacaaacaggactcagtgccaggtaccaactccagggctatctgacaccag
|
115561tttccctcctgcctactggagcagggctggacatggaggcacctctccccagtgaccttg
|
115621tcccatcccccatgtcctgagcctggctccttctatcctagcctttaatatggatagagg
|
115681agctctgacccaggcctggtcctctgacacttacctggctgtcttggcaaggatggaaga
|
115741gagcagggcctgctcatcagtgcgagcggaaggcaggctgtggtagttgggctcggctcc
|
115801attgagagctttggtaggggggctgctagggtccagcagcagcttccgctcctctcggtc
|
115861ctagaagtggtcatgggagagaagtcagccccaggacccgtagatcctgcctttcacggg
|
115921tgctacccttagcccagctctgaccttaaacaccaaaaatgtttctataaggaatatcta
|
115981aagtgcccagctttatggaatgccagataagactcagttcctgcctatccttgggagctc
|
116041aactgagttggtgttctaggataaatgagagtggaaccaggcagtcctagaggccctgaa
|
116101aaaatggacagaggcacaaagcaggtagtcagcaacagccctggagcttgaaaaacattc
|
116161taggacctggcaaagaaaggatactagaggctggaagacagWggagctgagacatagcaa
|
116221gcactgggatctaaaggggaaatcagtgcaagtcaagagcccaagaacagccttcctcat
|
116281cccctaggaccaggccttccccagcaaagctgttcgcttccaagatgRaagccctggcga
|
116341gtccagacaaagccctaggccccaagagaaagcaagcccaacctctccatggccatttct
|
116401caaattatgtcagggcaggaatcccagcccagctctgggtcacacagtacaagtgtgttc
|
116461ccttcttgaaggcaggtcccttcgaaggtgttcaccctcctgtgctctggtgctcttttt
|
116521gtacgtgactcccagaaccaaactgagtgtacatggtgtatcctgatctgagcagtacag
|
116581ctgtagccatgtatggtgattcacaccagtaatcccaacactttgggagcccaaggcaga
|
116641aggattgcttgagtccaggagtttgagaccagcctgggcaacaaagcaagacctcgtctt
|
116701tgcaaaaaaaaaaaattagctggacttggtagtgtgagccctgcagtcccacctacttgg
|
116761gaggctgaagtgcaacgactgtatgaacccagggtttgaggctgcagtgagYtaggactg
|
116821tgccactgtactccagtctgggcaagagagcaagaccccatctcaaaacaaacaacaatg
|
116881gcgctgttccctcccttgctaaaccacctgagtagcccatgtaaattttcagcagccctg
|
116941ttcctgctggcctgtgctgataatcacaacccctgaactaatgtaagaccaaaccaagct
|
117001tcctcattggtttggtcttcctccttgtcctctttcagtcccctgttctatctactgtaa
|
117061tatttctggatttgaccctgccttgagaccatcagctgcaaatccttgcttgctgtatca
|
117121gcagtaaatgagaaaaacagacctgctgggtatctatccaacccataaagagcaagagtg
|
117181ccctgaacaaagccaaggatRggcccagggggacatcctggctaatgctgactcaccaac
|
117241cttcagtgccagactcctcaatgctcccctccaggcctatctcagttcctcagtctttcc
|
117301tgctgcaggccgcagctcccctgcccacaactccacaactctccttgtagagggctactt
|
117361cctcctgccctgcttagggaggcccagccttttcaccttactcttctttctcaaggctag
|
117421gttgcccaagtgtcctcaggcaatttgatccagttcccaacagcaagagacagaagctgt
|
117481gggctttgccccatcacctctataaactcccagacacccttcctccctaaatacataggc
|
117541tcagtattaaagagctaaaaagacNaaatgtttgccaaagataaaactatgtatttctaa
|
117601ggaaagctggctccataatgaggcccaagttagcttcctatgtgtctgtcctcccagctc
|
117661cacttcagacagatcttcctgcaggacagggtagtctcttccctatcaggggttcttcaa
|
117721gaagaaggttggctgatcacttctcagccttcagctaagatcaagtgaacaacaaggtta
|
117781ttttcttgaaacccagacttaaagaagaggccatgctacctacttcagagcagacaaaca
|
117841tcaccccactcccaaagtgcgagtggagcatgggttaggtttgtcacatcaaggtttgtc
|
117901tctgcattagtgtaacccaagaggcagggtttcactgtctaccttagcacagacatagca
|
117961gcctgcccRtgactggccacctggtctaggggcatggctgagacagcttggccccatgga
|
118021taaagtacatggcctagcgtcagaacacctgggcactagcacttctcagcttggccaaat
|
118081cacttagcttctctgaacttcttcctcacctttcaatagacataacccacactaatatga
|
118141cggatgtctRgcaagagtcaaattagataactgtgaaggccctttgtaaactgtaacgtg
|
118201ttgtatattttttattatgataaagagacagagatgagagtcggagaggggcctgcccaa
|
118261gaactcaaagagggactgtgggatggtggatggttatggcccttgctacatgaggcctca
|
118321aatcacccagcagtgattaagcaccttctctgggtgttaggaacagaaatgagagccccc
|
118381caaggagaaggtagagattcaggagagcagcaggcccagctctcccttccaagtagaagc
|
118441ttgtatcctttctcatacggcattaatccttcttgactcattccctgcaagagtccatat
|
118501tatgctttaagggacaatttcccactaggctacagctctcccagtaggcagggttattgt
|
118561tgtctctttctcaaaaaggtggaagtgaagtgagaggtattaggcacaacacatgcctaa
|
118621cacagggcaaaggaaatatgtgttcattgggtgtatggagaattgagaaccagaagccac
|
118681ccttgcttcccatacaaacgacattttcctaggcttaagcccttaatccaaaatacgttc
|
118741actgaagaacgaactacttcccaagtaccagtgatataatctatttttgtgaccatcttc
|
118801cccattagaccgtgagctacctgaaacctttctactctctcaggtctactatatgttcaa
|
118861atgtagaatccgggcttagagacgatcaaaaaaggagagtagacagcaacttgagacttc
|
118921atccttgaatgtcaggccaggcagggcagggattagagtgtggggagaagtgagaatgca
|
118981ctaagaggaagagggagaatttaaaactgtacaggtctccccagcctaaccctttctcca
|
119041aaggtatcagatctacagccaaattctcagaataggcatgtctccagctaaaggaaccct
|
119101caggccccaggcagactgcactgaggcaagccaaactcagaaccaaatgaacttcccgct
|
119161ccatttctcttttcccacaatctagccaaagctaaatcctctttgttgcttcccagacaa
|
119221tttcccacatgtcccgatgtcctcactgtatcgattaaatccttcattggccaattcaaa
|
119281ggccaccaacttccagagtcgtcccctggccctagactagcagcgaccttccttctgcaa
|
119341ccccagggactaagacgatacacgaattcctgattcatctcaggacagactaactcaggg
|
119401cctcagcttacccacccctaaaatggattcgcaaagcccactaatacacagaagacacag
|
119461gaagctggggaagggagtgtttcccggggacctagactgaggatccttgaatctgaaaag
|
119521ttttgaaggtaggagcaaacggaagtggtgggagcgagccggacaggcggctgcctgcac
|
119581accccgaggcggggactgtgtagaaatctggggctttaacaggggtaggagcccggcttg
|
119641gcgtctcctctgtaatctgtcccctccaggcctccgtattcagtgagccctgcagtccgg
|
119701ctgcccgtcctccgcaggtttctttctgggccccatgccccagtgtcttagccctcattc
|
119761ccgagccccgcctgccgcggccgcacctggtccgagtcctcgttctcgctgctgtagcag
|
119821caccccatggccggggtcgggccgggcgctcaggccgcgccgaggagggacggcgtccgt
|
119881gaggagcccttccggtcacatgacccgcggcggcctcccgcaggcaaccacccgccccca
|
119941ccccccgtaccccctgtcccggagccgcttggccgcctcagtcaataccccggcttccgg
|
120001tcccgcccgctagcgcgtgatcgttgtcaaccaatgggaaggcgtaaccgtacacgcaag
|
120061cacgtgatgcggggaaagggcggggcggatcacatgacttcatctttccagtctctaaac
|
120121tggcagtagtggccatcgtgaattgtgttatgcgttctcgtggccactaggccacttttc
|
120181tgggccattgagcgaactcgtaccaaatgccctcgtatgcccttgtgatatactcttcta
|
120241aatgccatgcgaggggcgactgggatccaggcctgatgctccagatcgtacggtctgggt
|
120301gcacacacacagatgatccagatgaccagtacctagtcggggaacacagagggtgtatcg
|
120361cccagctgggctgggggtgaatacacagagggtgtattctccacctgggctggggatctg
|
120421cgacttacaggaagaagggaccttatactaccttcacatgctgacgcgcagcggagataa
|
120481atcctggtagaggagatagaagccacctcactgacctctctgctttcaggcttttatctt
|
120541taattctgccttttttaacagcacccattgtaatcgaacgcacaaagctgaccatcagtt
|
120601ctcttttcctaacccccgctccatgtcttcccttgggccctgaacacaggtccaagtccg
|
120661tccaagattgtatagtgatccatttgttgttcatgagcgtgtgattgggtgttcaccagc
|
120721atgtatcaaatgtgccaccctcaaatcttgttttggcacattacccgtctgacataacaa
|
120781gagcctgacacctctcccactgcatgttctggggtgaggggtggaggggtcagcaatgtg
|
120841tttcactggacatagagaaataatgtagtttcctgattgatctactggactttgtacatg
|
120901cagcctggtctgcctactgtctttactgtcttcgagactcagtacaatgtcctcctgatt
|
120961accttctctgactccattctctggacatgcccagctccctatgcttaatcctcatccagt
|
121021gttaattcatgcatttattgaatcaacaaatatttgctgagcgtctactatgtgccacac
|
121081attgttatatctggatatgcagcagttcacaaaacagccaaagtccctgtagtcatggaa
|
121141catccaatagtgatcacactatattgtattctctgttcctgggtcagtctcacctaccaa
|
121201acttgggagttcctggagcacagtgacaggttctgactcttccctgtagcccaaggcatg
|
121261gccttgcttacagaaaacttgcatatcaatgagcatgttacagtcaccccatcaccttgg
|
121321ctcaccccatgccccatcttctgatccaaagtattggagaagtcaccagatctcatacct
|
121381cttataacccctcaaatcaagaccctgaggttctgtaaatcttttgaggttcctgaaggg
|
121441taggaggcagctcaagctcgtccctggggctggtaacttgaactgcaggtctcaggtgac
|
121501agcagcagcctcagcatgaataattgaaagccattccagcctcctacctcagggttatcc
|
121561cccgcagcaggccctggactccccgacctgtcctgtgctctggtcctccagcccaggtaa
|
121621gcagggccctggattgtgggttcccaagctcaccagttcaagcccaccgcatcactcacc
|
121681tattcacacccatccatacactctttcatttttactccccgccatcaccaggggccttgc
|
121741aagaaggccggcaaggaggtcagatctggatgaggaggagaatggtccaggacatgggag
|
121801gagaggcccattccccataggtccctggagagaagagctgagtagagggaaaatgtgtgc
|
121861tgtgtgttatgtgtatgtacacatttgtgaagggaattctgagacagcacaggagaagag
|
121921gggaatacagcggagaggagatggggctggagaattattaaagaatcaaagactcctccc
|
121981atcctcagggaagagcaggcagagggagagtcctggggtgggaaagaggacatctcactc
|
122041taacaccctatggggtattttgattgcattttactgaggcagggcacagtgatagtgaag
|
122101gtgtttttgactgcaaatctatgctcttttgctacacagcagtggtcagaggagaccagg
|
122161caggcagagggtaggggtgggggaagatatcccagaggtgaattagtgaaaggggtcctg
|
122221aagaaggggtgacttcaaggataaagagaaacaagtcaggggaacaatgtgaagatggga
|
122281ccaggggttgggaccgggaagaggtggtttggggctgggtgctgaaagtagacagtatag
|
122341agtccttgaaagtacacaggcttggaatcacactaacctggattcaaatcccagttctgc
|
122401tctgtgactctggacaaaagacttagcctttctgagccgtggtttgtgaaatataaggat
|
122461aataattgctactggcaaaagctacacaaataggcaaattgtgggtatgggattccctcc
|
122521ctacctccctccaccccagggcccaggtagggaccatgtcccctgccattgcattggcct
|
122581tcctgccactggtggtaacattgctggtgcggtaccggcactacttccgattgctggtgc
|
122641gcacggtcttgctgcgaagcctccgagactgcctgtcagggctgcggatcgaggagcggg
|
122701ccttcagctacgtgctcacccatgccctgcccggtgaccctggtcacatcctcaccaccc
|
122761tggaccactggagcagccgctgcgagtacttgagccacatggggcctgtcaaaggtcagt
|
122821gttccctagccttctgctccaagaagtacccccaagacagtgaaggaatatttgggatct
|
122881gttgctgcttaactggatgaattgggcaggttcttgatcctcttttagggcctctttttt
|
122941ttctcatctggaaatgaggagcttggactaagtcatttattcagcaaacatttattgcca
|
123001cctcttttgtattaggaatgtgctaggtgccagggagaggggtagaggccacagagatga
|
123061atgagccacaaatgctggcctcaaaggaaccataatacacagtggaataaccatctcagc
|
123121agataacccatagctttgtaattatctgtctccacatctttcctctccaccatggaggct
|
123181tccacataccatttagggtagctgtctgcctggatttatctcaatcccagcataagtgct
|
123241tttagggtcttatttaagaaattcggctgtgtggtggctggtgcctgtaatcccagcact
|
123301ttgagaggccgaggtgggcagattgcttgagctcaggagtttgagaccggcttgggcaac
|
123361atggcaaaaacccatctctacaaaaaatacaaaaattacccaggcatggtggcacatgcc
|
123421tgtggtcccagctacttgggaggctgaggtgggaggattgcttgagcccaggaggctgag
|
123481gctgcagtgagctgtgattgtgccactgcactccagcatgggtgacagagcaagaacctg
|
123541tctcaaaaaaaaaaaaaaaaagaaaaagaaaagaaaagaaattcactggctgggcatggt
|
123601ggctcatgcctgtaatcccagcactttgggaggccaaagcaggaggatcacttgagccca
|
123661ggagttcgagactagcctgggtaacaaagcaagacccccgtttctacaaaaaatttaaaa
|
123721attagccgggtgtggtggtgagtaactgtggttccagctactggaaatgctgaggtggga
|
123781ggattgcctgagcctgggtggtcaaggctgcagtgagccgtgatcatgctactgcactcc
|
123841agcctgggcaacacagcaagacttggtctcaaaaataaataaataaaagttcatccaatt
|
123901ccaagatcagaaatacatttgatgagcaataaaaggggaatgaaactacaaattctaaca
|
123961gagacctttcataaatctgaaagatagggtggttgtttctgcctgggacttcatggagaa
|
124021agagcaacatttgaactgaatctggaagttctgagttggccaggcagatggcgatggggg
|
124081tgggaagggcaaagccagccacatatacacatgtggcatgaaggaatgagacagcttgat
|
124141ggattctgggcacagttgtttgggatggctgtgatacaggccacaggtgggaagtactga
|
124201gagatgaacctggaaaggtaggataggatcaggtccaaggtcctgaatgccaggctgaga
|
124261atcccaagttcaatcccaaaggccttcagctcacaggagccaaggagtaataaggtcaga
|
124321tttgttggaaagattccagggctggtgtgaagactacactgtaggagacggggaccagga
|
124381gggcagctggggctatggtacaagagacagatgagaccccggctggttgggagctgcagt
|
124441gaggcaggtaggcatttgagatatcttttatcaggggccctgcatccatctcccatgtct
|
124501tctgcaacagccatctcccctcataggtcagatcctgatgcggctggtggaggagaaggc
|
124561ccctgcttgtgtgctggaattgggaacctactgtggatactctaccctgcttattgcccg
|
124621agccctgccccctgggggtcgccttcttactgtggagcgggacccacgcacggcagcagt
|
124681ggctgaaaaactcatccgcctggccggctttgatgagcacatggtcagcctcccatctcc
|
124741ccaacccagatttttgtcaccccaggccttgcccccagacatcccttgtgaaggactccc
|
124801atctaaggagaaggaagcacctccactctggggactgtgatgctggatggtgtgtgagct
|
124861cctgccctcctgtcccaagtcatctgcacattattttctgccggatgacgaaagaaacag
|
124921ctaagaggaaggtctctggaacccagcaaatttgggtccagctcttactctgcctcttgt
|
124981tagctacgtgaccttgagcaaagcatgcatcctctgaaccttagcttcttcagaatggaa
|
125041atcacaatactgatcctgacttcttaggttctgaggtcagaggaaatgtgagaacactca
|
125101tgggaagctaagccaggacctggcatgaagtaagccagatcctggtggggtcttgactgg
|
125161gagaacaattccccccaccctcacctccagctccccctatccccacaggtggagctcatc
|
125221gtgggcagctcagaggacgtgatcccgtgcctacgcacccagtatcagctgagtcgggca
|
125281gacctggtgctcctggcacaccggccacgatgttacctgagggacctgcagctgctggag
|
125341gcccatgccctactgccagcaggtgccaccgtgctggctgaccatgtgctcttccctggt
|
125401gcaccccgcttcttgcagtatgctaagagctgtggccgctaccgctgccgcctccaccac
|
125461actggccttccagacttccctgccatcaaggatggaatagctcagctcacctatgctgga
|
125521ccaggctgaggtccaggcccaggggtacttactgatgcccacccccacccccacccaagc
|
125581agggacctcaaaatcccctccctttcctgtttggggccttgacacacgctgggctcaggg
|
125641ctagggagtctctcttcccacctctgacctctttcagcctctacactgacctcaagtgtc
|
125701aagttctatcaggctgcttggtctcactaggccccctctttccagagagaaccatggact
|
125761gacagcaagaagcctgagctcccgacccagctctgtcactgatttgctgagtgactccaa
|
125821gggaatccccaccttgctctgagatttaatcttctctcttaacacgaaggaagctggatg
|
125881ggagagctccaggggcctcccagttctcggcctcagaaagccccccatcctcagcccatg
|
125941ccattctgggtgggatcagaggaagtggcaatgagttagacgccctgcaggaatagctgg
|
126001atgcaagctgggccagagaaaatggcacagaaccctggacccagggccagggatgccctg
|
126061gccttccctaactctggcccacctagccaattaggtgtggctgatgtcccttgagtgccc
|
126121tcttcctaaagcccaaaagaagatgctggactcctctgggccccaccaacaaatagggaa
|
126181tagacatgggtggaaaatcactcctttgtctttattaaagaaacttagaccagacctggc
|
126241aatcaaggggtgaggtactggccaggaaggtggagtaggtttcaggccctggggatttca
|
126301agtgcagactgatggcctgggaggggccaaagagaccagatcctggcagcagctgaggag
|
126361gtgcccaagggcactttcaggcactggggccatcagctggttctgtgggcaggggttggg
|
126421ggttgggatgcagggtagtttgggctggcctggaatctccctgaggccaccctgccttgt
|
126481ctacctagatcatccactggtcctgatcctgttcgttgccttccatgtccacctggagag
|
126541gaggctgggtgtgggtggggaggggcctcagccagcctcagccccagatcctgcccctgg
|
126601ctggatccagggtttctgtaccccttggccatcaactgggtcaggagcaagggtccagga
|
126661acagaggccctcccccataccccttgcctacctcattgacctctccatcatccggtgact
|
126721cattgtagtcattcatctcgtccatgtcctgcatatcctcatcatcctctgagtcctctt
|
126781cactatcctcatcatcttcatcatcctcttcttcctcgtcatcatagtgctggtgggcag
|
126841gacagagcctgtaagccctacaggcctgcatggaccagttcaagaactgacccacttgag
|
126901cctctctctagggccaatgaatgaccccctaccccgacactccctccttgagtctagcag
|
126961gctggtgcatgttctgcaggaccttaatgctaggcccaatgcccaccccttctatctccc
|
127021cttttaggcttttacccagatctgagaaccacaactgctctgggtcagagacaggacatt
|
127081cagaattagagcagagcctcggtccactgcggcccccacacaggccccacctgctagagc
|
127141cactcacctctgaggctggcttgccaataggaaccaggttgttgtctttctccgcgatgc
|
127201tttggagctgtgggcaaaggcacagaggaacaaggccagagcccaagtagggcaggtcag
|
127261gggcatgggactggcccattctgcccagaagacaacccacacgtgttggggagaagcttc
|
127321ctcccagttctcagggagatacaatccctttcttgtcatctgccatttatgaacttgatc
|
127381caaatacttaaactctctgagccttcttttttttgtataattatggtgaggatgaagtga
|
127441gagacttatcagcctagaaagcatcatctgctagatcctcaattaatagtcaaaattatt
|
127501tcctgtgctttagggaaaagagcttgggctgagtgtcagcagcctgggctctaatctggc
|
127561ccagaagtcacatggtacccctgtaaaatagggtaccacaagatgagaaccttggctccc
|
127621tggctcccagcccgattattcccagctcagggcaaaaagctcttcctgggtagatttctg
|
127681gagtaaggctgggtcatggcccactgaaggaggtctctgtctgtgctgRggtctctgtgc
|
127741tgtgctagctgctcactcacccaggcctgatgctgctgttcctgctgctgcagctctgtc
|
127801tcttccacacagggtcgatccagattaaaccacagagtctcagtcacacgagggaagagt
|
127861gaggggaacaaagtggacatggctcctagactgagggaaagggtcaagtgaatgtgtttt
|
127921gctttgtttttgtttttaatttggttgtaatttgatttRgggatagggtggaagacagca
|
127981ggaaagcagcccctccccctaggaatcagacagacctggctttgagtcctggctccacca
|
128041cttactagctgtttgaccttggctgagtcacttaacctctctgagcctcagtgtcttcat
|
128101ctgtaaaatggggataataacaattataccactgtcaaagttattctgataattaagtaa
|
128161ataatggatcaacaaagctgtttgcaggctgttcaaggagggatgagaatgggagtcaag
|
128221tgtagggataggaatccagaatgcagactggcattatgaaattatacaaaattagaggta
|
128281gcagggttctactgaaactatccctacctcctccacacactaaaacctgctttttgaccc
|
128341tttatgatggcccataccacacccacccagtgtcagaaatttaggacactaacgacctct
|
128401catgaatcacagccaaatgtcggggtggagggattgtagcatatgcaagcagggttcagt
|
128461aagacattctaggaggcatgaataagtggataaataagtagatggaagattgaatggatg
|
128521aactaacattataagggtacaatcagctttgagcggctgagggagccgaccaggagtgcc
|
128581agataatctgaattaaacttaggacaggcgaactgaggcccagcgacaggcagagactgg
|
128641ctttaggtcatacagtgtgtcggggcttagaattcctccgtgaaagggatRagcaggaga
|
128701aaataatcgatgcctggtcctgcttttgtcttaatttatctgaccgacccagggccagcc
|
128761gctgcccttccctgtatctcagattcccaacccgcgtaattaggcacgacggtaaacacc
|
128821ctcatgtccaagaagtactgacagaccagcgatctcggctccgaaagcccaacccaccgt
|
128881cgcaaagccaccgccctttctttgctcattacgataatgaccatgcagttgaccaacaga
|
128941aagaaagcagggcgggtctcagacagaaatttggccttatagggttgctaaacgcgaaaa
|
129001aagcggggcctgggtaggaccaattaactgaaagaaatgctgggtgacaggaagtgacac
|
129061caatgaatgacggaccttgtgtgacSgggtggggcttagtctcgaggaagcggccaatga
|
129121gctggagctctttaagggttaaggactctcaatatggagctcctggggagtcgggtcaaa
|
129181ggaaatgggtttctctgggggaaaaaggaatgaaggggcaaggagacggttgcagccttg
|
129241cgtctgtacttaccgcgccgggaggctgctgccggcggcgacccggaagcgcttcaccca
|
129301gcctgagcggaagaacccaccagaatccgggactcaccaaacgcatgcgtccttcgtctc
|
129361cttttgttttccccgctcccgcccactaaaccggatgtgacgttgacctaccttagtcac
|
129421attgttagggaaggaagtgtgccgcgcctacctatctgccccSccttgagtctcagccag
|
129481tcggcgtctccatcctggcgccagcactacggtctcgtttaaccactgccccgtttaacc
|
129541cctgcccttttgttgccagtcaccatttgcttgttaaccccttctgaagaagagctgaca
|
129601gcaaccttttagtgcgagggccattcgtcctgctgcatcccagaaaactaatctgttact
|
129661acttcagaattgctggttgatgttaggcccctcctatctgtgctctctcagctacagttt
|
129721cccgtttgagcatattcattcttttttatttttgctctgaacaaaaatattagagttaca
|
129781atattactatattccaggccttgctagaaactggggataaatctaggaatatggtcgctt
|
129841ccctggaagacctcacagtccagggaagccaaaccctgcagacatgcagtagacttagtR
|
129901gtctctcttaaggttgcttgttgagttttgacattggagattatgtacagacttgaatga
|
129961ctagttagcctcaggcacagcattctgttgctgggggaatcagctgccctcctcaggcct
|
130021gggccaagtacacttagagatcgccctcgtcacctctcccatcctttgctgatgcctctg
|
130081ttctagtaacctctgactcagcttcgcctttagagatactcatgctttctggcaacagag
|
130141gtccttcaaacccaattcctattaaactccatcacttaccagcctctttcagggacagca
|
130201gttatccgcatttccagtactgtcctggccagatgtgtgagttttggcaattccttttcc
|
130261tctctctggactcagcttctttgtcaaccagcatcataatctctgcccagccttccttct
|
130321atcctgggctgatgtgaagattggataagaattgttcaagaggtcgtgtactgtgcatat
|
130381tgaatgtgattatattgccaaatagcactgtttgttatagtttttcattaaagagtaaac
|
130441tttgcctcttggaaatgactacctttttcattcattcaacaaatacctactgagtgcctt
|
130501agtatatgtccatcactattcttagtagtgggtatacaatagtaaacaaaacagaccaaa
|
130561aaagtccctcttttcatgcagccttcattctgagagaggtaaacaataaagaagatagat
|
130621aaataaaatatgtagttgtaagattgcagtaaataagagaaaaaataaatctgagaagtg
|
130681ggaataaaatatttgcaggggaggtgttttatttcagactggggggccaaagtcactggg
|
130741aaggtgacttttgagtaaaggtctgaaggagcagagagccttctgatatttgtggaagag
|
130801catttcagagagagagaatacaagtgcagagggcctagaatggcttgggcatagtgtcct
|
130861ctagggagagtaataggtaggagatgaggagttggggagccagtggagggttgtgagcac
|
130921agggtccacacaatctgatttacagtttaactgagttactctggctgttctccaaataga
|
130981ctggggtaggggagacaatggcagaagcagggagaccatttgggagcctattatgataat
|
131041ctagaggtagtggatgagaagtggttgaattctgaatttatttagatggtagagactaca
|
131101aggtttgctaacagatggacaatgccagaataagaaaggagccacgatttttgggctgaa
|
131161cgactagaagattggtgttgccacttttttgagttgggaaggaatggggaggtgatgagg
|
131221ggtttggtttttttttgacagggagcttaggtttgagtgtgttgagtctgagatgcccat
|
131281tagagtagagatgttggggcggcaggaaggcatatgagtctgcaggtcagggcagagatc
|
131341tgggctggatagatcatttgggagtcattggcatgtagatggtgtttaaagtcatgagac
|
131401tggatgagatcaccaagggagtgaatgtagttggaaaatagtttcctccaatattcagaa
|
131461tttgaggaaactaggaaaagcagcaaaccagatggagaaggaaggccaaaaagataagta
|
131521gaaagctgggtgagttgatggtatcttggaagccatgtaaagaaagggtggtaggagaaa
|
131581atggtttactgcagcctcattctgtacaaaattgtgcttttgtttatttccccaacagac
|
131641catgagctccttgagggcagggactgaatggttactatgtccccagggcccagcatgacc
|
131701ttctcctggattcctcatcttccttctgtgacctgtgtctccatcagtttctcctccggc
|
131761atctttttcttacaggattcttacctcaggtaccatttgccccgtccttcctgataattc
|
131821cgcctgctggaaattccctagtaacagagtttcttttcagggtcatcagccaggctcagt
|
131881aagtaatgatgactggttagctggtgacatttattgagtaccaactgagtgccagacacc
|
131941tttctaggccctggggacagaggggaagcagaaataattcctgccctagagaaaaataga
|
132001gtatagtgagtactaagacaattatagacaattatagaggagggtaataaatgttaaaat
|
132061caatgtatgtagagaatacatgagaacacagaggagggattgatgaatgggttctgaaca
|
132121aactaagtttagacttttgttccagaaaaggaaacatttgagtgggccttgagggatgag
|
132181taggagttaagcccactggtaaataagtaggaaaagagggtgcacaaagaggcatatttc
|
132241attcaagggcatgtttggagaacattgagaatctgggcagaactagatatgtggagtgga
|
132301gaaagatgagaaagaatgataggggacccagatagggaaggtctttggtggccctatatg
|
132361gagtggatgggatgggatctgggcatcttgggtctcacctttgtcttattgccgacttgc
|
132421tggggaccccaggtagatgtctccccattcacaagcttccgtgttctctaacataatatc
|
132481taaccatgtcgccagctctgatgtgagtccctggaagggattcccctagcttgatccttt
|
132541ccattcttagatttttacatttgccttatttgtgatttatacaaaccagggcctaggaat
|
132601ggaaagcagggtcaggatggagatttctcaacagaaatcaataaatccagagcccagagg
|
132661ctgaagatggaaaccatgattctatgcagagaattctctaggatccaggaagggccagag
|
132721ttgagtggtgtgaattcagtgctagtgaaagctgcttactcattccttccataaaccttg
|
132781aggagcatggctgaccctggtaggggacaggggagaatgtaacagtcacagtcactacct
|
132841ttcatacatatggagggatagttggtctccagagagttttcccactcatagtctccactt
|
132901atccttagcccagccctggggattctgccttcatttagcagatgaggaacctgaggctca
|
132961ggaaagtaaagcggcttgtctgagttgaagctacaactcaagaatgtcaaaatcttgcat
|
133021tgttccacaaatcttccttatgggctgatatgtgcttgccgatggggactcacagaggaa
|
133081ttcgatttgagtcctagtcctctgcaactacccagtatggtgtggataccagactaacgc
|
133141aagtcattaggcccttgaggccagatctctgtgtgattcatctgtatttccccggcacct
|
133201tgcacagtgtctagcacagagtagccactcaacaaatgtttatataagatgggttttttt
|
133261ccttgggtctaatggaattatagttcacgtgatgaatggtataacagggataggttctaa
|
133321aaagagaaaagtgggaatgttaaaaagtgaagagcagtgtgggaggggaggtggagaagg
|
133381ctcctcagagaagatgagaccttgcaagaggagttaggaaagaatattctagtcaagagc
|
133441agacagcatgtgcagaagtgcagaggcctgaaagggtgtggtgtgcccaggacatggcat
|
133501tgaccgagggcctgttgtgtggccatcgtggtgatgtgcactgtgaaagaaacaggacca
|
133561ggagacagtaccctgtgctcaaaggacaaggcacagccttggaggaggacagggacatgc
|
133621tgagaaaggcttccttgagcaggggagacttctgctgggtcatgaaggatgcttcatagt
|
133681tcgagtcagagaggaggaaagaggaaacctcccaggtgtgaggggcctccttaggcaggg
|
133741gctgtggttggaaggaataaggagaatgcccaggcaggagagcatggtgtgtggagggca
|
133801ggctggtcgggtgggaggggctgcagagctccactgggtgggctagctgagggagtgcac
|
133861cttagcgtggagtataaggcttgttctgcctcatggtcactcaacacctcatttatttcc
|
133921catcattgtggcctccctggacctgactctgagtttgggatggatagatgcgttggaagg
|
133981gatctctgtgaattatcttccagttccctagaaagccagccccaggagaggtgctccagc
|
134041caggtccctatctgcatggtggttttgcgtatgtttgcttaccacaaatatatggtaagg
|
134101tttcctcactaaggtttaatgggctaaggtttcctcactctgactacagcaaaatagatg
|
134161caaagtttgaagagaggccctctgcattggaggcaaaggctgaggagacacagacctaca
|
134221cacacacacaccccccctcactttcatgcagaggtggtaggcagaatgaaggctccctgg
|
134281agatacccatgtcctaatcctatggtgtgtatcctacctggcaaaagggactttgcagat
|
134341gtgattaaggttaaggactttcacatggggtgattatccaggtgggcccaatctatttac
|
134401atgaatccttaaaatcagataaaactttcccagctgtggtcagaaaacaagacgtgacaa
|
134461ggaagaagcatcagagagattctacattgctgactttgaagatggaggaaagggccatga
|
134521gccaaggaacacaggtggcctctagaagctggaaaaggcaaggaaacggattctccccta
|
134581gggcctccagaaagacctactgtcaccctaatttttttttaattttttaatttttttgag
|
134641acagtcttgctctgtcccccaggctggagtgcaatagtgggatctcggctcactgcaacc
|
134701tctgcctcccaggttcaagcgattctcctgcctcagcctcccgagtagttgagattacag
|
134761gcgcccaccaccacacccggctaatttttgtatttttagtagagacggggttttgccatg
|
134821ttggtcaggctggtctcgaacccctgacctcaggtgatccgcctgcctcagcctcccaaa
|
134881gtgctggtgtgagccaccgcacccggcccctgacaccctaaattgagacgcatgttacac
|
134941ttgtaacctgcagaactgtaagttaataagcttgtgttgtttgctgggcacagtggcaca
|
135001ttcctgtagtcccagctactcgggaggctgtgataggtgtgttactggatagtgctctgt
|
135061aatttcaggctcttggtgtcctgaacaaagaactggaccagacacacacagatattaagc
|
135121acagtattacactcttagagggggagagtggactgacctctggcagatgagatcaacatt
|
135181agttttgtgtactctgggtctttgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtg
|
135241tgtgtgtgtgtgtgttctcttcccaaggctgcctaatctctagccagtgtctgccttttt
|
135301gattgatagatgtgttgcttagttactttggcccttgtgtgtcacctccatcccataatt
|
135361ttaagtacatgagtgatttgcagtccatatgcatgagcttcaatgagctaattaccaaac
|
135421ggggtcattttaaggatactttttctctttaatgtgcatgcccatctctgaggagctgcc
|
135481cgcaacaggtttggtccggatttagcccagatgggggcttctttttcacttttgttttgg
|
135541ctgttctggtttttatctcgcttcttgctcacctgccccttcacctggcttctgctccct
|
135601gcttttactcattctgcccttgatccaaattttaattccctttgctattctcctgctgta
|
135661ttttccctcttcccctgcttcaggaggatcgcttgaaccctgaagtttgggaccagcctg
|
135721ggcaacagagcgagaccttgtctcaaaaatcaattaattaattaatttgtgttgttttaa
|
135781gccacttagcttgtggtagtttgttatggcaccaacagaaaacaaatgcacaggtacaca
|
135841cgtatatcctcccaccctgatagacaaccacagtcatacacgctcaggcagatacaggca
|
135901gggagacccaggaacatcagctggccctaagtgggggctggggagaaatgaagcttcagg
|
135961tgtgtgctgcggggtgggtggtaaggcctgctccttggctggtgtggagaaactttgacc
|
136021acatttctcagtcttaactttgctctgcttcctctcagtccttacgtcatacttttagca
|
136081acctttacaacaacattttgtcctaaaccctgttgcaaatacatgtatgaacctcaaaga
|
136141ctatatattaaatgaaataagccagtcgcgaaaggacaaatactgtaggattccactttt
|
136201ctgaggttcctggagaagtcaaattcagagacagaaaataggatggtggtttccaggggc
|
136261tggggagtagggagttattactgttttggtatttttttgtttttacagatatcctgtttc
|
136321tacttaaagagttattaccgttgtcaagctgggcatggtggctcacgcctgtaatcccag
|
136381cactttgggaggccgaagtgggcagatcacgaggtcaggagatcgagaccacgctgaaac
|
136441cccgtctgtactaaaaatacaaaaaattagccgggcgtggtggcgggtgcctgtagttcc
|
136501atctactcgggaggctgaggcaggagaatgtcttgaacccgggaggcggagcttgcagtg
|
136561atccgagatcgcccactgcactccagcctgggcgacagagccagactccRtctcaaaaaa
|
136621aaaaaaagagttattaccattgaccatgaacaacacaggtttgaattgcatgggtccact
|
136681aatatgtggatttttttcaatcacagataaaaaatacagtattcagaggttgcgaaaccc
|
136741acatatatgaagggtgggacatcagtatgtgtggatttgggtatggggggctcctggaac
|
136801caatcccctacatctgttgagggaggattgtatttaatggatacagtttcagctggggaa
|
136861gacaaaaagtgttctggatgagcctggtcatggtggcttatgcctgtaatcccaccattt
|
136921tgggaggccgaggtgggaggattactcgagcacaggagctcaagaccagcttgggcaaca
|
136981tggcaaaactccatctctaccaaaaatacaaaaattagccaggtatagtggtgtgtgtct
|
137041gtggtcccagctacttgggaggctgaggtgggaggattgtttgagcccaggaggtagagg
|
137101ttgcagtgagacaagatggtgccattgcactccagcctgggtgatagagcaagaccctgt
|
137161ctaaaaaaaaaaaaaaaaaaagagttctggatggattcacaacaatgtgaatgtacttaa
|
137221tgtgagtgtactgaactggacatgtaaaaattgttaaaatgataatttttattatatgta
|
137281tgttgtcacaattaaaaaaaaaaacaacttgtagattaggcaccattttggagaatgggt
|
137341tcgggggagcctccagtcgaacttccccactgcagtgcagctggaaactcagtaactggt
|
137401tctctgacacctccccgccactcccaccccagtgccacatatccccatctccatgcccca
|
137461ctccagtccagagccatctatcgcctgggctactgcaataactggctagcttcccgccac
|
137521accacttcaaaccatacgtggctgcctaaaacctttccctggcttcccattgcttttagc
|
137581ctgtgagttgaagtccttgccaggcaagatctgcccctgccttcctgtccaccctcatct
|
137641agagccaacctcgtccttgctttctgcaccccaaccacaccccaacagttttgcagatct
|
137701tcagacccactaaaacatgttctgcctcagggcctttgcacaatgctcccattgcctggg
|
137761actctgtccttcttctttactgggtcagctccctccRttttggtctcaagagaggtcccc
|
137821cctgcagattagctctggtgcaaggagcactcttccatagcatcttctcttttcctcatg
|
137881gcatctcacctaatacatacactcacacacacatttatgtgtgtgtgtgtatatgtgtgt
|
137941gtatatatataaaacatatattttatatataaaatatatgttttatatatataaaatata
|
138001ttttatatataaaaaatattttatatatataaaacatatttttatatatatatataaaat
|
138061gtatggtaaaatatatgtaacaaaaaatttacaattttcacctttttttttggacactga
|
138121gtttcactcttgttgcccaggctggagtgcaatggcgcgatcttggctcaccacaacctc
|
138181cacctcctgggttcaagtgattctcccacctcagcttcccaagtagctgggattactaca
|
138241ggcacgtgccaccatggcctggctaattttgtatttttagtagagacggggtttctccat
|
138301gttggttgggctggtctcaaactcccgacctcaggtgatctgcccacctcagcctcccaa
|
138361agtgctgggattacaggcatgagccactgcgcccggccaattttagccatttttaaatgt
|
138421acagttcagtggcattaagtacattcacattgtgtgtaaccatcactacatccattcccc
|
138481agaactctcatctttcccagctgaaactctgtaattaaacagtagctccccacccagcct
|
138541ccccaagcccctggcacccaccattctacttagtctctatgaatttttactactccaggt
|
138601accttaaatggaatcatacagtatttttctttttgtaattggcttatttcacttagcata
|
138661atgtcttcaaagttcatctatgaagctgttgttgcatgtgtcagaattttcttccttttt
|
138721aaggctgggtaatagtcatttgtacatatcacatgttgcatatccattcatcttttgata
|
138781aacatttggattgtttccacttttgggctattgcaaatagtactgctataaaaatgattg
|
138841aacaaataccacctattttaactatacatctaattgtgtgcttattcgtttaaattgtgc
|
138901ctctcttcctcatctctgggcatcacaagtgttcaccagcatatcctcagcacccagcac
|
138961agtacctgggcatcagtattcaacaagtatctgttgaatgaatgaatgagacaccaaaat
|
139021atacctactggacatatacagtgtctgtagtgtgtaaggaagagcagaggacttgaatct
|
139081ggggcccagctcattgattcctcattgcgtgctctgaccttgaccaaggcccttcacctt
|
139141tgtaaaccaaagagtatctgagacaaatctcaaccaatttaggaagtttgttttgccaag
|
139201gctaagcatgcacccatgacacagcctcagggcgtcctgacaacatgtgcccaaggtggt
|
139261tggggcacagcatggttttatatattttaaggagacatgagacatcaatcaatatatgta
|
139321agatgtacattggttcagtctggaaaagtggaacagcttgaagtgggggtgggggtcttc
|
139381ctggtcataggtagttaagagataaccatttgcattcttttgagtttctggttagccttt
|
139441ccaaaggaagcaatcagatatgatatgcttttatctcagtgagcagagagatgactttga
|
139501gttctgtctattctttgtccacaaattatgaggaaggtgtgtagttttttttctttttaa
|
139561tcttagtagctatttttcttggaatagaatgtgaggcaggtttgccctaagcagttctca
|
139621gcttgactattccgttagtaattgacttggtcttagtaattgacttttcccatagtaatt
|
139681gacttgcccttagtaattttggggccctaagatttattttcctttcacaccttcaaacct
|
139741cagtttccccatgtgtaatgtaggggcactatcagccccacagagttcttgtcagggtca
|
139801aacgaaacaatacatgtgataaggttcggcttctgacccaaggaactgctcagtgaccta
|
139861atctagaggccttgatctaagtactgagggagagaggaggctccaactgggggagctgac
|
139921tgactggattcgaatccagcccaaggtctgttacccatcctctggggaccttggctctgt
|
139981attcatttcctgtagctgctataacaaattactacaaacttcttggcttaaaccacacag
|
140041atttgttatctttcaattctgaaggtcagaagccataaatcaatgtgtcagcaggactac
|
140101attccttgtggaagcttccaagaacaatcaatttccttgccttttccagcttccagaagc
|
140161cacctgcatgcctgggctggtggcctcccttccttgtgtccctctaacctcttgtttcca
|
140221cctttatgtgtcctactactctctctgagctcctgcctccctcgcatcaggattacatca
|
140281agtccattcagaaaatccaggatcatctccccatctcaagacccatttcttaatcacatt
|
140341tgcaaagtcccttttgccatataaagtagcattcagatgttccagagattaggacgtgga
|
140401cacaggtaccatctctctcccatgtgggcctcagtttgcattttaggaaaataagagcat
|
140461tggtcatgccctgtcctccctgtcacccttgctctgtggagttctacctgaggcaggaat
|
140521attgggtggaggccagagggttgggtcctgcctgcctgactaccctagcacccaaattct
|
140581cacaatcttgtcaccagcagttatagccccagggcctggctgtcccccaacccgtgttcc
|
140641agtgccccactgttcccttccatttcctgggtgcttctgattcaggactttttcctggac
|
140701ccttcactggactcacaagaggggtgccctgtttattcagtccaccacgctcaatctctt
|
140761gcaggagggagcacatgagtgagtgagtgcaggatctggttggctgatccaggtgctggc
|
140821agcagcaagctccatgcagggccctcggccagtctagatgtgagcgagcaagggcaggat
|
140881ccagccggctgctctgggcactggcaggagaaatctccatgtggggcctgcggcagtgcc
|
140941caggtgggggtgcccatgacccctaagccccagagggagtattacagtgctctcctagtt
|
141001ctgctgtccatggacggtggtgtgttagcagctcagttggccccttgcatcgtctcatgg
|
141061ggtggttgccctctgccagcaagggcaaagagccagtgtgacagcctttctgggtaccca
|
141121cacttggtgggtcccgagcccttggccagtgtccaagaagaatgaggttgtgcagacaat
|
141181tgaagaatgatgaaggtggagaattttattaagcaatgaaaacagctctcagcagaaagg
|
141241ggagctggagaggaaacaggaagggccagtcatcttcccccgaagtcaggccatctcttc
|
141301tgtagtccagccatctcttcctcaaagtccggttgtctcctcgaagtccagccatcttcc
|
141361catctactgactgagtctggggcctttatatgcacaggacggggagtgcatgctgattgg
|
141421tttgtgagtatgcaaaacaggttaaagtgaagacatcactcaaagatgggcatgacagtg
|
141481tagaaaaccaattaggaaagggtaagtatatgtaaaataggtgaagggtggggatcaatc
|
141541agaggaaagcacaacaaatgggaagacaagtcttcaatctggtctgaggatttagcttgt
|
141601agcttggctttcaggctttaaactggctttggcttggaagtggggtttcaccagggacca
|
141661gtccctatttgcctaggcatttggctgcctcctgtccctctcatttccccctctgaagag
|
141721gtacaactacctgttgttagaatagggacaaagacaatcttaactacttcctgctgacag
|
141781gggatgctgttttgagcaaacagcaatcagagctccctcagaggcctatctaagcgtccc
|
141841aggttaaagggagccatcattcaaggctctgttcggaatttgatggcctctaagtgagaa
|
141901gaaacagtttgggttattagatgacatggatcaaaatggaacaacaaggaggtaaagaca
|
141961gctcaaaaatcccaagtctgctgacatgcccagataactagtggctatagttatgcctgc
|
142021taagatttggatgcatggtgcttggctttggtttgctcccttgttttcattttcccaaaa
|
142081aaacctccagattatgagcaccacatcctatttactcctatcagctgcaggataattgcc
|
142141cagaactagaatattgattcatatttttacattacccatcccctctatttcttctgagct
|
142201acaaccagagatcactagttggttcacaggaataagcaggattaatctaaaatgtaggca
|
142261aaagcttaaaaacaactgaaactagaatttaatgacaagtgtatgataaattttgaaaca
|
142321taatttttctctctccagtcctcatttctgttaaaaataaaccatgataggactgagttg
|
142381tttgcaaaataaactttagtcttatacttggcctggtcatttgcataaagtgcagcaaga
|
142441ataatcattttcacataggcttttaaaattggctttgatggaactctgtttcacaaggaa
|
142501tctcaggtaggaccttttaaagctgagctcagccatgggtttgtaccctcaaatacctat
|
142561gagttgggtaaattcttcttttcttgaggtcccagataacacagggctcttgggcctgtt
|
142621agaaaatgacattctctactcaccacaggttaggaaccctgtccagggactgtgtagaca
|
142681aggtatgaggccagttttcccaaggggattttattggctctgcaagtcaagcttgattcc
|
142741ctaaaggaaagcataccattccagtcaaaaccttggtaaaataaccggtttctccagtta
|
142801tatcctgctgcaaaagaaaatagattcttattgcactgatgcaaataactatattgccat
|
142861aagttaagaatatttgcaaatagtttccaaattctagagaaaccaggcagagagaaatat
|
142921gctccaaattttcttcacaggagtataccttactcaattgttaaaagctgtagatagctc
|
142981aaaagaagtttccttgactctggaaaaaacaaaacaaggatcagcaatgttttaagcaaa
|
143041aagttaaaaaggattacttcagttttctattagttcagtttattcagttaactcttgttc
|
143101tgcttgatattcaggagaatttcagctctttatgactcctgtatgtttttcctctgttcc
|
143161aatgtcacaatctccaaagtcatcagaaacctgcatttgagggcacctttcaaagtccaa
|
143221tagctgtccacaaatcatcttttgaaaagggtcaaaacaagacaacaattgtctgtgaat
|
143281gacaaaatatccttgggtagtcacagtcaaaaacacaattgacaaagaaatttgtttttt
|
143341ctctgtggtttacaataacttaacacaataaccttaattattactgatagcatatactca
|
143401gacatttgagttttagaaggcccatacaattaggccgggcaccatggctcatgcctgtaa
|
143461tcccagcactttgggaggccgaggtgggtggatcatgaggtcaagagatctagaccatcc
|
143521tggccaacatagtgaaaccctgtctctactaaagtacaaaaattagctgggcatggtggc
|
143581acatgcctgtagtcccagctactcgggaggctgagggaggagaatcgcttgaaccctgga
|
143641ggcagaggttgcagtgagccaagattgtgccactgcactctagcctggtaacagcgcaag
|
143701actctttctcaaataaatcccatacaattttggaacatatattaatattattcactaaaa
|
143761tataccctgaagaaagtcatacattatttttattttggcaatcccatgtaactaaatgtg
|
143821ttaaataatcctgtttacctctcttttggatgctccaggggccttcagtagcatccaaaa
|
143881gttaggggttagaaaagacaaccttgaacctgaagtttgaatttgggaagtctatcaaac
|
143941acattaaagatttaaaacacttattattttgaaatagaactccagatcaccataagttat
|
144001ttattttagccaaaatgatgactcaaaaattttaaaacaaggcaaaaacctttcattatc
|
144061ctttattattacatgaaaatcttcttcgagagaaagtcaaatttcacccttgcatgtaaa
|
144121tccattttcagtagtctcaattacatgttgtaatggtaactcttagcaatttttaatttt
|
144181aatgtaaaacctggtaagtttttttaattatgtactaggcacagataaagtctgactctt
|
144241tacaacatagttaatggtgtggttaatccatatgaccccagaccttaccaaattgtaaag
|
144301ctggcaagtcaaacagttctcaaaagccaaagaagcagtttataaccttacaacatttag
|
144361caaacctagtatctgacctgcatacattagaccacatattttcattttgataacatttgt
|
144421attttaccaattatcttcaaaattgtttttctttctcaaagattaaagtcacatgaacta
|
144481aaaggcaatacagcttttgtttttccttcaaaaaatatttgatctaagcacttattttct
|
144541ttaagcaaattagagctctttttttatataaacatcacacacaaataacacatatgtgat
|
144601tacacagacagaagattcagtagttgtaagatttttcatttgccaatctcctaattggat
|
144661tattggcctcagggtggagcatttcaagaagcagagctaggaaagcatgcagtttccagg
|
144721gcctaataaacaggcatagctggaagacaaaaacagattttgaaaggggtctatctgctt
|
144781ttaattcctggggttctataagaaaaacagagtttttttttttttttccaaaatgggatc
|
144841cgtggtgacttctctgtttttcccaaggtgtcttatgctctcagaagttatcttagggcc
|
144901tctcatgcatgcgttaagagtgacaagacaaattggggaaaaataattcagttgactgag
|
144961aaaaaattgttttgcagagaaacaagatccatgaagaaaaaaacacaaaggccttttaaa
|
145021tatacctatagcttggatatccacttttaattaagctgagcactctttaagataaccctt
|
145081ttaaatcccttagtacccaactttagccatgccaagccacgaatatttctggcttttgaa
|
145141ctttaccatttctttcaacattttgcacagggagagagaggccagaggcccgactggcag
|
145201aaaacttttacccttctgtccacatgttcacaattctttccccttctcactccatcctta
|
145261ttccactctcagccttcctcatctcagtaaatagccaagcactcctctctaattgctcag
|
145321accaacacactctggagtcatcctaattcctccctttctctcatgtcctccatctcagca
|
145381aatcctatcaaaacatccttcaaaagacatgacattactcctcccttttcaccacgtcca
|
145441ctgccaccacatagccctggttcaagtcatggttgccttaaggctgggccattcacatag
|
145501acatctgtgtcaattgtttgctttcccttgtccctagagtcagatcagatgctgaactgg
|
145561aaaaagcaaataaagtttccatttcattcagagtaaaatcccccatctttgctgagtctg
|
145621aaccacggggccctgaagatctggcctggaccccacacctgccgctcccagctcactgct
|
145681ggccacactggcctcctcctcgctgtttgttcctgaaatgcactgagtacatttttgctt
|
145741cagggcctttggacctacgggtccctctgtctggagcactccttcctccatgttcacatg
|
145801actcccttcttacctcattatggtatcagcccaagcatcacctcctagatctttcctgta
|
145861gaagatagtagcccctgcttcatcactctctgtccccttagcctgcttcagttttcttca
|
145921gagcacaatcatcatctttatttgttttctgtcgtctctctctaacaacctcccaccccc
|
145981aaactagaatgtcagctctatgacagtagggactttttcttggtcacttctgtagctcta
|
146041gaacccagaacagcctagcacatggtagatgcccaataactaattctgagcttagttttt
|
146101gaatgaatccccacttctaccctcctggtcaaggcaccatcatcccaggcctggacttgt
|
146161gaaacagctttctaactggtctaccttgcccaattccagcctacacgtaatcccatctga
|
146221acacaccaagactgccaattgaactgtgacattcccctgcttaaaactctttcactgtga
|
146281ccagttgtagaaacaacattttgtttatccatttatccatccgtggacacttgggttgct
|
146341ttcaacttttagctatcgtgaattaatgctgctgtgaatatgactgcacagatagctgtt
|
146401tgcatccctgctttcaattcttttgggtgtgtgcgcacaagaggaattgctggatcatat
|
146461ggtaattctatgtttaattttttttcacagcatctggaccattttacattccccctccac
|
146521tagatatgttattatatacaaaggtggacggctatacaaggacattccctacagcattga
|
146581ctataacagtgaaatatgagaagccacttaaattcaatagaataatgaaatagaatcata
|
146641tagatctatgtacacagataagggaccatctatagtacattctgttaagtaaagcaagca
|
146701aagtgagctgggcacagtggctcatgcctgtaattctagcactttgggaggctgaggtgg
|
146761gaggatcacttgagcccaagacgtcaaggctgctatgacctatgattatgccactgcact
|
146821ccagcctgggtgacagagagagaccctgtcaaaaagaaaaagaaaaaagaaaagaaatca
|
146881aaatgcaagggaattaggggttattcttcttcctgaggactggtgccatggcatccagag
|
146941aaagaacattggtggggatactgatgaaaaagaataaagtttgtagattagttaaaagta
|
147001ttcccttaatgttaatttcctgattttttaagtaattgggctttggttttgtcagatgcc
|
147061aacatttggggaaactggatgaaagcatatgggaaacctctttactacttttgcaatttt
|
147121tctgttaagtctaaaattatctcaaaacactaagttaagaaaatcaaataaacttgatgt
|
147181cttaaaacaataccaattaggctgggcgcagtggctcatgcctgtaatcctagcaatttg
|
147241ggaggctgaagtgggccgataacctgaggtcgggagttcgagaccagcctggccaacatg
|
147301gtgaatccccacctctactgaaactacagaaattagcctggcatagtggcatgtgcctat
|
147361aatcccagctacctgggaggatgaggcaggagaatcactggaaccggaaggcagaggctg
|
147421cagtgagctgagatcacaccactgcactccagcctgggggacagagcaagactctgtctc
|
147481aaaacaaaacaaaacaaaaacacaatacttatttacttatacttcaagattttgtgagtt
|
147541taattatacttcaagattttgtgagattttgcccaagaatttgggcaagactcatgattg
|
147601gcccatcttggccgggcgtggtggctcacccctgtagtcccagtattttgggaggcctag
|
147661gttggaggattgtttgagcccaagagttgaagaccagcctgggcaacatggcgaaacctc
|
147721ctctctacaaaaatacaaaaattagctgggcgtggtggtgcgtgcctgtagtcccagata
|
147781ctcagggaggttgaggctgcagtgagccatgatggtgccactgcactccagctggggtga
|
147841cagagtgagaccctgtctcctaaaaataaaaaataaggtaaaataaagattggcccatct
|
147901accctcaacagttgcctggactccctggggctcagtgcacctagatgctggactcggata
|
147961accatctgatctttgatgtagtggacagacactttgttcttgccatcatctttggtacct
|
148021gagatagaaagccttaaagagaggccacgcccatgattaagtttcaggtcaaaacaacga
|
148081gcaaaaaggcaacggctatagttgtaggtgtagcaaatcagtgtgccttttatctagagg
|
148141ctactgaaaaccagacattcattaaagatattctggtcacttggatgaaggctggccttg
|
148201gcattcacctgaatctttagtagagtctttagcaccattggcaactcagccagacctggc
|
148261cttggccacgatagtggagcctgggattggagggcatgaattttatgaagcctgtaatat
|
148321cagaaattcgttggttgaggacatacctctttctttttggaccctgtgggcgtaatgcta
|
148381ttgatacatgtgcagaggaggaattaatatgactgtgattgacagaataattatgaagtg
|
148441caaagacctcagatctgtgatcagcttccatagaagtatttgctcagaagcttctcagaa
|
148501acattctcatgattgaagaagccttgaagagcccgtatttctgtctatgaaatctcctgt
|
148561ttattgtactatgaggacccatcagaaagtaactgaggtagtgctgatttcctgagcaat
|
148621tattcagtccactgtctcaaatccatcatgcagaatgttcacagagggtaaagtaagttt
|
148681gactattataactactcacttttataagtgatttaatttaaagattaatatgataagtac
|
148741tctgtttttcctgggaattttgttgtagaaagagtaactgctgtgtggctaaactaaggt
|
148801tataagccaaattgtttcctcagagtttaagaaacacaatactaactctcatgggtttac
|
148861tagttgtctgttgctgcataacaaatcattccataattttgtggtgtattgctgcagaca
|
148921atgttaaactaagtggatgaaaaggatattcacatagtctcagagtgtctccctacaagg
|
148981taggattactaacaaagggaaactaataattatatagtaaggaaatctccttaacccaat
|
149041aatcaccagcaataagatgcagcaaccctcatcatgtacctcttgatatgatgcactgac
|
149101aaaagcacctctcttctctaattttcttgccaaaatgcataagctcaagctaattacagg
|
149161aaaatatagacaaacccaaattgagggacattctgcaaaataactgaacagtaattctcc
|
149221aaaagtgtcaaggtcataaaagacaaagacattgaggaactgtcacagattggagggaga
|
149281ctaaggggacatgacaactacatgcaacctggaatcatggactgaatcctgggccagaga
|
149341aaggacattgggggggaaactggtgtaaagggcataaagcttgtagattagttaacagta
|
149401ttgcctcaatattaatttcctgatttttttaagaactgggctttggttacataagatgcc
|
149461aatatttggggaagttgcataaaaacatacgggaaatcttttgacgatgttttgcagttt
|
149521ttctgcaaatctaaaattatttcaaaacaaaaagtttaaaaatcaaatacacatagttgc
|
149581ttgaaatagtaactattttattatattccaagatgttgtgagtcaggaatttggccaaaa
|
149641ctcaggtgggcgattcttctgcaaagacccccacaacacattcaaagtcacaggcagagg
|
149701ttgttgggggagggcattgaaaagaagagaagagtcataggtgggtgcaatggagggagg
|
149761gcagagggctgctgactatggtgcaggactcatccataatggagccctggggaggcaagg
|
149821gcttcataactagacactggtcttgtcacctcagactcacctgtagcaggaccagatact
|
149881gaggtcagactgaaaacacaggctctgcctcaggagaggctctctactagctgagtaaat
|
149941gatgacagtattggaaatgttcccaacatcataatgggaaaacatcacttcacactacat
|
150001aagcaatacacaggggcagtgccggtcgtcttcccaggttagtagcagttctactgcctc
|
150061caagagtgttggagaaatacaaaccaagcattaggcacttttaacttgaaaacatgaagt
|
150121tctctttcctaactttctttgtttccttatttcttcttcttcttcttctccttcttcttc
|
150181ttcttcttcttcttcttcttcttcttcttcttcttcttcctcttcttcttcttcttcttc
|
150241tttcttcttcttctccttctccttttccttcttctttttttgctgagacagggtctcact
|
150301ctgacagtacagtggtgccatcacagctcactgcagcctcgacctccagggctcaagcaa
|
150361tcctcccagctcaccctcccaaatggctgaaactacaagctcgcaccaccatacgtggct
|
150421aatttttctatttttgtgtgcagatgaagttttcctatgttgcccaagtggtctcaaact
|
150481cctgggatcaagtgatccatccacctcaacctcccaaaacgctgggattacaggtgtaag
|
150541ccaccacacccagcccactaacttttttatatcggctaatgaaatagttttaagtttaga
|
150601ccctacgaggcataaagaaataattttagttatgttatcagatgtacagtaatactcaag
|
150661tgtgcaactgtggataacttgagttcatgaggtttttgtttttttgtcaaaagaataaat
|
150721ttatagtgaaactacccaaaaaagcaaagtacagaacagtatgctaccatttgtgcacag
|
150781aaatgggatatatatggtgtaactgcatcgaatttactggatgtatgtccagggaccaga
|
150841actcttggtggcttcatgttcatacttttgcaagcacatgtgtagtatccttaacttaaa
|
150901ggtactgttgtatacattctagtgttatcaaaatttacatacatattatcaagtcagaga
|
150961ggtcattctgtgtcttagtattttcacttcatatttggtatatttatgtatgtatacaca
|
151021catacctatatgtatttaaataagatttatagtcacatggtccaaaaatcaaaacaatgt
|
151081ggaaaggtttacagagaaaagtctcaagcctaatcctgttctctactgccaggtgaccat
|
151141gttattaatttcttttcataccttgccacagaattttcacctgcaaacacagatattctt
|
151201ttcttttttaatgacagagtcacgttctgttatccaggctggagtgcagtggcgtgatct
|
151261tggctcactgcaaactcctcccgggttcaagtgattctcctgtctcagcctcctgagtag
|
151321ctgggattacaggcatgtgccaccacacccagctaatttttgtatttttagtacagatgg
|
151381ggttttatcatattgaccaggctgatgtcgaactcctgacctcaagtgatccgcctgcct
|
151441cggcctcccacagtgctgggattacaggcgtgagccaccacgcccagtcaacacagacat
|
151501tcttactccttttttacagagaatttattattattattttttacatagcatttttctgca
|
151561cctttctttttccacttaacaatgcacttgaagatttttccatatttgtacatcaggagc
|
151621tttctctttctttgttaccacattaaattccactgggtagatgtaccataatttaactgg
|
151681gtccttattgaaagacaattgagctgtctcctagacaaagccttgtgcaccttcccKaac
|
151741agagggtctaaccaagcaggcaggatggggttataaagtaggtggggaggtgggagagac
|
151801tccaccttcccaggtgggctgagaatggaggtaaggccctgcaacaggacagagggaaaa
|
151861gtggggatgagaggtgggaggcgagatagcgcccactgttctcgctcagccccctcctcc
|
151921gtttgccgctgacctgttggcctcccccaacctctgagcctgcctctgcctaggtaattt
|
151981cccaagacccagaaggggtgaagggtgaggtgtgattgcccccacctccttgcctcccgc
|
152041agcatctgctccgggaccatgaacaatagctgacagctccatggcccttgctgtccccat
|
152101ctcagcttccctgggcatctaaacctcagYtgccatggggtaggaggacaggctgaggaa
|
152161gcagaagcctgaggctgtctagagtctcactcctgcatcagcaggccaccacctgtggtt
|
152221cctccttgtgcaaatttgaaaagaattgcataaaacactggagaaatccaagaggggaag
|
152281tccacaagggcggtggctccctacaaggtcacagagcaagctggtgtcagaRcctggacc
|
152341tacagcgctgttggtggaggtcctgcctccaggtaggggaagggctccctctcacctcta
|
152401cacgcagcgcatttcttggctcagctgccctgtaggggatgcagggtggggacagcagag
|
152461atctgggcctgggagggagagagtacacaatcacatggctgttgcccctgtctcaggcct
|
152521tgtctacctctgactgtggctctctggcaggaatagatggacatggcctggcagatgatg
|
152581cagctgctgcttctggctttggtgactgctgcggggagtgcccagcccaggagtgcgcgg
|
152641gccaggacggacctgctcaatgtctgcatgaacgccaagcaccacaagacacagcccagc
|
152701cccgaggacgagctgtatggccaggtgagggcagcctggtgtaggacagcatgcacacag
|
152761gtcagagggtgatggcacgagcaatggcaggtccagtgtggtcagaaccaagggtgccgc
|
152821tgctgacaaggaaggggaggggcggccagggccaccatgccacaggtaaggccactgagg
|
152881cagcttggggaatatgagctccaatttgaactccaggctcaggagtgtgcttgtatttca
|
152941ttcctctggtctcctggcctgctccctacaaggtttcacattcccagagggctggggatg
|
153001tgcctagggagagactgtggcgtggacacaatctgtgggttaaagcgaagacaggacagc
|
153061ctggaagccccatgacatctgagtcactcccaacattccatttgcttatttttaaatcgg
|
153121ggttaaaaaaaaaaaacaaatacataacatacattttccactttagccatttttaactgt
|
153181acggttcagtggcattaggtatgctcatgtggttgtgcaaccatcaccaccatccatctc
|
153241ctgacctctttcattctccaaaactgaaatggaaactctgtgcccaccacttcatttgct
|
153301tttcagaaccttctagagcacatcctccttgccaggaaatggtgtggatgtagacctttg
|
153361agagagacagatgactatcattctcagggccatgagctatatgagagtgatgatatttgt
|
153421tgagcccttactatagcaagggagttcttctcattgtactcagtaactcttttggaggca
|
153481acaacccttgaccctgacaggcaggacccatgtctgccaaaccctaagacccatgatgtg
|
153541caaggggtcttgcaggaagaccaagagttggaacatccaaggaaaagcaagtgtgaagtc
|
153601gggctggcagggaagcatgttctgtgtcagccggcactgggcgtgggccagggtgtggga
|
153661ggtgggtaggtctggctcccctcccatggatttccctattgtttctcctgggtgctcagg
|
153721cctgtcacgcctctgccatcacttgaccctaggtgcaagggttcagcccagaaattttat
|
153781gcaattgaYtcatgatttctcaggttttctgaRtcctggcctagagtgacttcccaagaa
|
153841aaaMctccaccatttctgcttgtcttacctgccttgtatttacctttctaggattgcctt
|
153901ttccacatttagtcaagtctaggttcagacccacgtgcaggctatagctccttcgttctc
|
153961caccactctcaggatctatctagagtctccccacctggacctccagaccctgggagagcc
|
154021agaccagccccttgacctccaccctcccccacaacctgggccaggttcctctcctccctg
|
154081tcctcagttataattttttttttttttaatttgaggcagagtttcgctcttgttgcccag
|
154141gctggaatgcaatggcatgatcttggctcactgcaacctctgcctcctgggttcaagtga
|
154201ttctcctgcctctgcctcctgagtagctgggattacaggcgcctaccactgtgcctggct
|
154261aattttttggtatttttagtagagacagggtttctctgtgttggtcaggctggtctcgaa
|
154321cttctaacctcaggtgatccgcccgcctccttaaatcttaacctcactgtttaccatggg
|
154381tgtagcttacttaaactctgtaaaaatgggggtaaggattcgtactgggttgttgagagg
|
154441ataaagcgcaaaagcctcagggactttgcacctatggttttctatgcctagagtgttctt
|
154501tgtctcccttctacacacagcccacccacccactaaaaccataccctccctgagggtaga
|
154561ggtgttatttgttttcttcactgtggtgttcctaggacctagcacagtgcctgatgtata
|
154621atcagcactcagttaatattggctggatgcaaaatgaataatataaataagctgaataac
|
154681atgaaataggccgaacgcggtgactcacgcctgtaatcccaacactttgggaggccaagg
|
154741agggtggatcacctgaggtcaggagttcgagaccagcctggcaaacatggtgaacccccg
|
154801tctctactaaaaatacaaaattagctgggcatggtggcacgtgcctgtaatcccagctac
|
154861ttgggaggctgaggcaggagaattgcttgaacccgggaggtggaggttgcagtgagccaa
|
154921gatcacgccactgcactccagtctgggcaacaggagcgaaactctgtctcaaaaaaaagt
|
154981tagtttaataacatgagatcactttttaaaccgttaagagctgtactactaataattact
|
155041ctctcagacagtggctctccctcatctcctatatcccgtggattaccctctgttaaaagc
|
155101caaaattaagcaggcatggtggctcacgcctctaatcttagtattttgggaagctgacat
|
155161gagccaaggagtttgagaccagcctaggcaacatagtgagaccccatctctacaaaaata
|
155221ctttatattagccaggcatggtggcatgtgcctgaattccagctcctcgggaggctgagg
|
155281tgggaggattatttgagcccaggatgttgaggctgcagtgagctatgatcacaccactgc
|
155341gctccagcctggtcaacagagcaagaccctgtctcaaataaataaatgaataaatagggc
|
155401ggaaagcaccaatattgtaattgcctccgtccccaggtgggagctcctcaagggccctcc
|
155461ccaggaagtgttcctctggatgacctacctggggcagaggagccagaatatggaggagat
|
155521ggctgtggtggggagagacttagtcctgtgtcttccccacccagtgcagtccctggaaga
|
155581agaatgcctgctgcacggccagcaccagccaggagctgcacaaggacacctcccgcctgt
|
155641acaactttaactgggatcactgtggtaagatggaacccacctgcaagcgccactttatcc
|
155701aggacagctgtctctgagtgctcacccaacctggggccctggatccggcaggtatgagtg
|
155761ctgttcccacaaacattaacctcagcagagggcggagcctgccagttgctggcagggagg
|
155821gcttggtccaggaattcgggtctgagggtggtggacgccctgccccctcccacagctctg
|
155881gtccccttcaagggtaaagctgctgagatacgtggctgacaggagtattctgtctcctcc
|
155941ccactcaggtcaaccagagctggcgcaaagagcgcattctgaacgtgcccctgtgcaaag
|
156001aggactgtgagcgctggtgggaggactgtcgcacctcctacacctgcaaaagcaactggc
|
156061acaaaggctggaattggacctcaggtgaggacctgaggagataagatgaggagtgggagt
|
156121ggggctttggggttgggaggggtgcggtctggcccagaagctaagggtcttacgttctcc
|
156181tccctcagggattaatgagtgtccggccggggccctctgcagcacctttgagtcctactt
|
156241ccccactccagccgccctttgtgaaggcctctggagccactccttcaaggtcagcaacta
|
156301tagtcgagggagcggccgctgcatccagatgtggtttgactcagcccagggcaaccccaa
|
156361tgaggaggtggccaagttctatgctgcggccatgaatgctggggccccgtctcgtgggat
|
156421tattgattcctgatccaagaagggtcctctggggttcttccaacaacctattctaataga
|
156481caaatccacatgtgtcttgtgtcttgtaatttcgggacgagtgggttggagggacacatt
|
156541gcttcatcttttccattgacaggccccaaattgggctggaactagcctaatgttcactgg
|
156601gaaggagggtgtgggggttgagctagaatccaggtatctgatccgttagtctgggtctct
|
156661tacccctgcactggcttccccctcatgccaagctcatcccaccggcactacacatggaga
|
156721aagacacagacggagtgaagaagggcagagatagccgatgagttattgggcttcaagttg
|
156781ggaagagagtttctttagtgatgtgggctgggtggagatattggtggggaggagggtctt
|
156841gatgaacacttgccttgtttccatttatttatttatttatttatttatttatttatttat
|
156901ttgcgacaggaatcttgatatattgcccaggctggtcttgaactcctgtgcccagacaat
|
156961actccctccttggcctcccagagtgctgggattataggcatgagtcactgtacctgacct
|
157021gctttttaaaaaaaaatgacaactaatgttgcaattaacaatcttttacttagtggaatg
|
157081ttatacttaaattccagaaaggattattgggtcaagagtacatataattttgagagttac
|
157141aactttatgggggttgtatcaatgtgcctcccccaccagcaaagtatgagagtgcctctt
|
157201tctccactgggtgtgatggctcatgtctgtgatcccagcagtttgggaggctgaggcagg
|
157261agaatctcttgagcccaggagttcaatatcagcctgggcaacatggtgaaaccccaactc
|
157321tacaaaaaactaaaaaatcagctgggcatggtggtgtgtgcctgtagtcccaactactag
|
157381ggaggctgaggtgagagaatcgcttgactcccagcaggctgcggttacagtaagctatga
|
157441tcatgccactgcactccagcctgggcaacagggcaagacattgtctcaaaaaaaaaaaaa
|
157501aaaaaagagagagagagagagtgcctgtttctccacaaccttgtcaacccactatgccat
|
157561taaactttggttttctgctcatcttacaggtggggaaagggcagctcagtgcagttttca
|
157621tctgccattgttctgagatctttccatattgacctattgatatgttaaattaccaggtag
|
157681taatccattctaggtgtacattacattgaattcagtctcctactgatgggcattggaagg
|
157741aatggggttcttttatgatcctgacattgctgaaagccacaggccagttatttagtagaa
|
157801tactcctccatttgggtttgtctgtttcctcatgattcattgaggttatgcgttttgggc
|
157861acaaataccctacatggttatcccgtgcatcataatgggaggcatgtggtgtggggtttg
|
157921ctcattcctggtgacgttaactttgatctttttcttgagattgtgtctgccaggtttctc
|
157981cactacactttcccctttgtaactagcaaatatgttgtagagagagactggagaactaga
|
158041gatactctattcatcagcacacttccacctatatgttctagtagctgatggaccttaaac
|
158101atgtcttactatgttacagctctttcaccaacccttcaatacttttcagtggtatcaact
|
158161gtaaaaaccaaacttcttcacaatagcacagaagaccatgcccctcctttgagccctcaa
|
158221gccaaatctctcccacaccaccccataaatgagctccagtcacatttctcatgttggggg
|
158281tctttgctccagcaactctttctctgcatgcctgaaatgttcttcattaatcctctgcag
|
158341cctagcactttgtggccacttagatcacaacctacaatccccccctaaaatgacttctga
|
158401ccactcaaactgacaaacccacccagctgatttctcatcacactactctatgtccttgtg
|
158461cagatttttatctactgtgtttgttgtcagccttttccctaacaaaacatactctcccga
|
158521aagcagggttgtgtctgtgtcattttatgctacatccccagggtctgggtcagtgcctgg
|
158581caccgagaatgtgctcagtaagttaaggaatcgctgcatccattctgtcagtcaacaatt
|
158641ccttctgagcatccagtccactggcccatgctggtctcagccaacagaaagggaattgag
|
158701ttccttgcaaggtctggtggggacagacagttctgagaaccagtgactcttagaacaagg
|
158761agatgaggctttcacagagggaagcacagagtgtggtattattctgctgaagcccaaaga
|
158821ggtcagggaaggattccaaaggagtaatgtttgccaagcacaaaacagcacagggaatgg
|
158881cattccatggacaggtctcagcaagtgcaaaggcttagaggtaatagaagtgcaagcaga
|
158941attccagggtggctaagagaggttgtgtggggaatgggcagcagttaaggccaaagaaga
|
159001aacactggatctgcattccttaggacggtgccctgtgggcccctcacagagcttctctcc
|
159061tgcaactgctaggtataagaaggcaggcttagaatcggactgagatcagtagtttctgca
|
159121gctgggaagatgagtgaggtgagattgcatgtgtgataggctggcactcagggaagacct
|
159181cagggttctctcctccccactctgaggcccctctcctgcttcctgaagcccagagtctcc
|
159241acctctgtgagccaaacaccttcctgttatctgcctggtcctagggtagccttcgggttg
|
159301gggttagaaggaatgccaatggttaaccttgtggtattaagcttccagctcaggcagata
|
159361ctctctggactggttcaagctgactgcctgactgtccctccctgctggccctagcaccca
|
159421gactccagataggcacaccacctcacccttcagagcagggctctgagactccacaagtgg
|
159481tgaggacttaccagaggaactgaacttgacctccaacccaaccttccatttgctggtatt
|
159541attctgaagccctcatggcccaggggcctgcctcaggtagcaggtctcactcctgcagtg
|
159601gaggggccataaagttcagttcatgatcagcccccaagccaggggcagcggatgacaggg
|
159661caggagttccatctagaggagctcctgtgttcaggcgttcctagacacctgcctgccctt
|
159721ctcccatcagcactggggtataaagaaggaaagaggcctgaggtttccagaggcctctac
|
159781ctgctgaggtcttaagaggactcaaccctctgggaaatacaaataaaatcctcaaccctc
|
159841caaacaactgaatggacacctcttggccaaagagaccccggaaaaactttaaaatccaag
|
159901tttcctggccgtgatgataggtcactcacacctcagcacacctgcttcctcacgaaccgt
|
159961taccaggcttctttcccaagagctaaacagaaaccagccctgaaaaccaagaacaggaga
|
160021ctccttcactgatttcaatttcaaccaattccgagactcccttccctttcctgattttga
|
160081catgacagctgatcagcttacaaaacattcctggctgatcaatgactctcaaccatggac
|
160141cagttctggctggtttacagaggcagcacacaaagtgctttgggtcctgtgtttcacatt
|
160201ttgacatacagagcctaattcaactgcattttaatgtctccaccccgaagtgaatatggg
|
160261acatatttaacatgttttattggtacacatgtgtgcaactctcatgaatattcataaatc
|
160321ctcttaaaacttattaaatatatatgtttagccaactgatttagtgtaaaacccctgtcc
|
160381cttcaattcctagcttgtaggttgcaacccatcaaaagaaataaagctctcttttccaaa
|
160441tgtaaagatcttatgattttaagccaatataattgaagacaagagtaggatccatggagc
|
160501agcccaggttcccccagcctaagtgaatgcacaggtgccaggtggagccattgacagctc
|
160561atttgtctccctgacagctttgggaggaaggtgggtaagctctccccgatctaagatctc
|
160621tcacttttgaattgagatctcgaggacttcatttttttaccctgatcccctccatccgga
|
160681ccctgcaagtgccatctttgttggtcccaggtttctagatggggaggttgggggcagtta
|
160741agcctgactcatccggcgcatcagcccatcaggtttggtgaggatgcttgccctctagtg
|
160801gcacacgaaggaatgtcttatgcttttctggggaatctagattctaaggagacagtccca
|
160861gaccagctgccatcaggaacatgcatgtttcagaattatgagaaaaagtcttgtgaatat
|
160921tttggatcctggaaaaaagctaacctggaacaatataaagatttataggccaaaatggag
|
160981aacttttggcagaatgtctgacatgcctaaattagtttatttgcatgcacaatagggttc
|
161041aggacctctcagaagcaatgggaggtcttttttttttttttttttttgagacagagtctc
|
161101actctgtcatggggagtggagtggagtggcacgaacatggctcactgcagcctcgacctc
|
161161ccaggctcaatcatcctcccacctctgcctctcaagtagctgggattataggcatgcacc
|
161221accacaccccactaatttctttattttcaatttttaattttttatagaccatgctggtct
|
161281caaattcctggactcaaggaatcctcccacgggagaccatttttcagtgttattatgaga
|
161341gctctaaacacagttgggagtctcagataacctccttaaatgagactaattcaaaactga
|
161401aggagtctaattcaaaacttgaccagcatattcaaacctatctgccactattggacaggt
|
161461agctgaagacactgcaaaaagccttatagcccaacaaattgaattccctggctcaagtag
|
161521taatagataatttaattgcttcagattttcttttacccaaacaaggaagagtctgtgcag
|
161581tggcccataacacctgttgcacttacatcaacacttcaggtgaagtagaaactcatatag
|
161641ggttgggcacagtggctcacacctataatcccagcactttgggaggctggggagggagga
|
161701ttgcttgagctcaggagtttgagaccagcctgagcaacatggtgaaaccctatctctaca
|
161761aaaactgcaaaaattaaccaggcatggtggcacatgcctgtaatcccagctatttgggag
|
161821gctgaggcaagaggatcacttgggcctgggaggcataggttgcagttagcctagatcacg
|
161881caattgcattccaaactgataaagcaagactctgtctcaaaaaaaaaaaaagaagaaaaa
|
161941ctcatacagaaagaatttccaaacaagctaaatgattacaagaaataaaactactgatcc
|
162001tatcaatgatctgttcagttggctttctaccaaacagaaattcctttcaagatgctattg
|
162061aaggctgggcgtggcggctcatgcctgtaatcccaacactctgggaggctgaggcgggtg
|
162121gatcatctgaggtcaggagtttgtgaccagcttggccaacatggtgaaaccccgtctcta
|
162181ctgaaaaatacaaaaaattagctgggtgtggtggcgacacctgtaatcccagctacttgg
|
162241gaggctgaggcaggagaatcgcttgaacctgctaggcggagattgcagtgaaccgagatc
|
162301acgccactgcactccagcctgggtgagagtgagactccatctcaaaaaaaaaaaaaaaaa
|
162361aaaaaggtgctattgaagtttttgttataattatagtctccatcaaacttttcttcataa
|
162421catttaaattacttataatatgggacaggcatgggggctcaagcctgtaatcccagcact
|
162481ttgggaggtgggcagatcatttgaggtcaggagttcaagaccagcttggccaacatggcg
|
162541aaacactgtctttactaaaaatacaaaaattagccgggcatggtggcatgtgcctgtaat
|
162601cctagctactcgggaggctgaggcaggagaattgcttgaacctgggaggcggaggttgca
|
162661gtgagccgagatcacaccactgcactccagcctcggcaacagagggatactctatctaaa
|
162721aagtaaatataaataaataaataacttataatatgtataaccaactgctgtaagtctgct
|
162781gctaaaaccagaattatgctggctcaatgcatagaacttatagacaagttaaattggtag
|
162841ccctaccttttggcctttatattgcttgatagaccttaggggttgatgagtacctgccca
|
162901cctctatttctgtctggccaagatgttcaattggctgtaagtctcttggccacaagggtc
|
162961ccaccaagggactggatggatctggagcaggtagcctcagcatcctggcaacgacatggt
|
163021acaaacaatttggccattgatgctgactgtggcagatcttggctaaaaggaagaaatgtg
|
163081gaataaaaagaaaatccaaagacccctcaactgactgaacaaacccctcttggccaagga
|
163141gaccccagaaaaactttaaaatctaggtttcctggctatgataagacaggaggctggtca
|
163201cacctcagtataccctcttccttactgttaccaggcttttttcctaagagttaagcagaa
|
163261tcctgtcctggaaaacagagaatggaagactcctccgctgacttcagcttcaactgcctg
|
163321atgccatggccagacttcactctctttttgtgatttgacacgacagctgaccagctcaca
|
163381aagctatccttcctgatcagttcctgttaaccatgggctggttctggctggtttacagag
|
163441gctgcacacaaagtgcctttgtgtcctatgtttcaccttttgatgtgtatggcctaagtc
|
163501tgcattttaatgttaagtctcagctgggtatggtggctcaatgcctgcaatcctagcact
|
163561ttgggaggccaaggcaagaggattgcttgagcctaggagttcaagaccagcctaggcaac
|
163621atggtgagaccttgtctctatttttttaattaaaaacaaaatacaaatataaaaataatt
|
163681actgttaactctccaccccaaagtgaacacaggatgtatgtaacatgtatgtttgcttag
|
163741tatacatgcatgtgactccctttcatgaatattcatagctcctcctataacttattaata
|
163801agtatactagctaacctatttagcataaaactcctgtcccacctctcctccctcaaagtg
|
163861cctgctttccatctcagccagaggctccacttcccagcctgcaggttacaacacaatatt
|
163921agtaaaagtgttctttccaagtgtatacatctggtgattttaagttgatacttcccaggt
|
163981tgtccaagattcaggtacagctcactattgcaggatacaagctgggatctcctgggagtt
|
164041ggtctctttgcaaatcgtattatctctgtatcaccttttatgaaatcctaaaagaattta
|
164101aatctgaaacatgtgactccaaagattttgaataaggaattgtgaacccatggtaaactc
|
164161ctggcttaagggtgtccaattttttggcttccctgggtcacattggaagaataagaaagt
|
164221ttaagaaagtctgtgaatttgttttggggcacattcaaagctgtcctggccacatgaggc
|
164281ctgagggctataggttggacaagcttctagctggctatttctgcattttgtccaaatcca
|
164341tcttttaattattatcattattattattattatttgagacggagtctcgctctgtcaccc
|
164401aggctggagtgcagtggcgcgatctcagctcactgcaagctctccctcccgggttcacgc
|
164461cattctcctgcctcagcctcccgagtagctgggactacaggcgcctgccaccacgcccgg
|
164521ctaattattttgtatttttagtagagaaggggtttcaccgtgttagccaggatggtcttg
|
164581gtctcctgacctcgtgatctgcccacctcggcctcccaaagtgctgggattacaggtgtg
|
164641agccaccgcgtccagctgaaacataatttttctctttttggtttcacatttttactaaag
|
164701acaaatcatggtaagactgatttgctttattatacttggcctgattatttgtgtaacgtg
|
164761cagcaagaatacttacttttcacataggctttttaagttggctttgatggaactttgttt
|
164821tgtagaagaatctcagattagactttttcttttaaggccgggctcaggggctcactcctg
|
164881taatcccagcactttgggaggctgaggagggaagatcacatcaggagttcaagaccagcc
|
164941tggccaacatggtaaaaccccgtctctactaaaaaacaccaaaaactagccaggcatggt
|
165001ggcaggtgcctgtaatcccagctacttgggaggctgaggcaggagaatcacttgaacctt
|
165061agaggcaaaggttgcagtgagccaagatcacaccattgcactccagcctgggcgacagag
|
165121cgagactctgtctcaaaaaaacaaaacaaaacaaaacaaaactttttttttaaagccgag
|
165181tttggccatgcggttgtaccatcaaatacctatgagttgggtgaattcctcttgagaacc
|
165241caagatgatttggggctcctgggtctgtcagagagtgacattctttacttgccacaggtc
|
165301agaaaccctgctcaggatctgtgtagaaaaggtatgaagttagttttcccaaggggctct
|
165361tatcagctctataagtcaagtttgattccttaaaggaaagcacaccattccagtcaaagc
|
165421cttggtaaaataactggtttctccaattgtgtcctgttacaaaagaaaacagattctggc
|
165481tgggcacagtggtcatgcctgtaatctcagtactttgggaggctgaggtgggcagatcac
|
165541ttgaggtcaggagattgagaccaacctggccaacacggtgaaaccccgtctctactaaaa
|
165601atacaaaaattagctgcttgtgttgtgtaattgggtaataagagattttaaagaattttt
|
165661tttgtagagcaccatggtttaaagtcagcttaattaaaattagatattcaagctctaaca
|
165721gcctgggactccttggggaaaacaggaggcgccagagacaccattttggaaaaaaaccct
|
165781gttttcctcttggaaccccaggaattgaaagctgataaattcctctcaaaatttaaggct
|
165841ttgttctgttttggattgcagtatctgaagtttttgacttttggtctatcagaaattata
|
165901tcgcattatgagagagttttggtgtgtaataactaggtaggaaatatactttaaggaatg
|
165961gctaatggaaattatagatgatcacgtagctctttgcatgtttggattagagaagcatgc
|
166021tcttggccacctggaaggtatggaaataccttttttttttttttttttttttttgagaca
|
166081gagtctcactctgtcaccccggctggagtgcagtggcaaaatctcagctcactgcaatct
|
166141ctgcctcctgggttcaaaggattctcctgcctcagcctcccaagtagctgggattacagg
|
166201cacctggcaccatgcccagctaatttttgtatttttagtagagacggggtttcaccatgt
|
166261tggccaggctggttttgaactcctgacctcaggtgatctgcctgcctcggcctcccaaag
|
166321tgctgggattataggtgtgagccaccgtgactggctggaaatatcttcttatctcccact
|
166381gagagataagacttccacagaagatgggctgattcccccttttttggggagggatccagg
|
166441gtctggtataaaatgggatcttcattttgggggatctgttttgccttccagctgtgcctg
|
166501cttattagggccaaaggtacttgggagtcccagctatttgggagactcaggcaggagaat
|
166561cacttgaatccaggagatagaggttacagtgagctgagatcacaccactgcattccagcc
|
166621tgggtgacagagttagactctgcctcaaaaaaaaaaaaaaaaaaaaaaaagaaagaaaga
|
166681aaaaagagacagattatttagattatttatttacttactttttttttgagatgcagtttt
|
166741gctcttgtcacccaggctggagtgcaatggcacgatctcggctcactgcaacctctgcct
|
166801cccgggttcaagtgattctcctgcctcagcctcctgagtagctgagattacaggcacaca
|
166861ccaccacacccagctaatttttatttatttatttttagtagagacagggttttgccatgt
|
166921tggccaggctggtcttgaactcctgtcctcaggtgatccacccacctcagcctcccaaag
|
166981tgttgggattacaggcgtgagccactgcgcccggccaagaaacagattcttattgcactt
|
167041atgcaaataactatattgctataagttaagaatactcacacctagtttcctaattctgga
|
167101aaaatcaggtagaaaaaaacaaatatgctccaaatatgttgccagaagtatactttactg
|
167161aattgtttttttttttttttttgagacggagtctcgctctgtcgcccaggccggactgcg
|
167221gactgcagtggcgcaatctcggctcactgcaagctccgcttcccgggttcacgccattct
|
167281cctgcctcagcctcccgagtagctgggactacaggcgcccgccaccgctcccggctaatt
|
167341ttttgtatttttagtagagacggggtttcaccttgttagccaggatggtctcgatctcct
|
167401gacctcatgatccacccgcctcggcctcccaaagtgctgggattacaggcgtgagccacc
|
167461gcgcccggcctactgaattgttaaaaggtgtaaatagctcaaaatttttcctgactctga
|
167521aaacaaaacaaagtttcagcagcattttaagcaaagtcaaaaacatttcttcagtcttct
|
167581atttgttcattccatgcagttaactcctgtcctgtttaatcgtcatgaacatttcagctg
|
167641tccatgagtcctgaaagtttttcctctattctgacgtcacaatctccaaacttatcagaa
|
167701acctgcattcaagagaacctgtcaaaatcctatagttgattataaaccaccttttgaaga
|
167761ggatcaaaataagaaaacaattgtctgtggttgacagaagtcttaggacagccactattt
|
167821aagccacaattgaaaaggaaatgtgggggtgggcacggtggctcacgcctgtaatcccag
|
167881cactttgggaggccgaggcaggcagatcacctgaggtcagggatttgataccaacctggc
|
167941caacatggtgaaaatccgtctctactaaaaatacaaaaattagctggggatggtggtggg
|
168001tgcctgcaatcccagctactgagagtctgaggcaggagaatcgcttgaacctgggaggtg
|
168061gagttttcagtgagctgaaattgtgccactgtactacagcctgggtgacagagtgagact
|
168121ctgtctcaaaaaataaaaaagaaaagaaaaggaaattttggttagttctgtgacaacaat
|
168181tttacataacaattatgactattaataacatacactaagttatcaaggaattatgggtgt
|
168241tttccataattttggaacatgtccaataacatatttatgcaaatataggccaaagaaagc
|
168301caaatactatttcacatttgacgatgcttcctttatggattttatactgaataagccaaa
|
168361tttcacctttacgttagtgtactattaatgttaaacccaattctttaataaaacctttta
|
168421gacaaatttatttaatcttaatcagtttgaccataaagtaagattcttataaacttttgt
|
168481ttcctcacctccccagaaaagtggatcctaaaccttttataaccctttacaatttttgtg
|
168541aacgagcagattaatgctctaagaaaaacctgttgtgcttttattccaatgtttgattta
|
168601tagaaaaaatgaatacccctttaactttagccaacatgttcacacagaatttcttttatg
|
168661acattaatttttcacaaacctcccacaatttgttcaagccttcagctttatctcatctaa
|
168721aacaatcctttaaccctttaatctaggcagaaaaatccacattcccatgacttcttataa
|
168781tcttttaccaaaaacacatttcactttccttacacaccttgcatgtaaaactgatgttat
|
168841ttcccaaagattactaaaggcatataaactaaaaggcatcacagtttttatttttctaat
|
168901aaaatatttgatttaagctcttattattttttaacctattaatcaaagctcttttatatc
|
168961tcacacacacaacatatataaatacacagaccagaagatccagtagttgtaagaattttc
|
169021atttgccagtttctttttctttctttttttttgaatcggagtcttgctctgtcgcccagg
|
169081ctggagtgaggtggcttgatctcggctcactgcaagctccgcctcccaggttcacgccat
|
169141tctcctggctcagcctcctgagcagctgggactacaggcttctgccaccacgcctggcta
|
169201agtttttgtacttttagtggagacggggtttcactgtgttagccaggatggtctcgatct
|
169261cctgacttcgttatccacctgcctcggcctcccaaaatgctgggattacaggtgtgagcc
|
169321accgcgcccggccatcatttgccagtttcttaattggattactgactttagggtggagcc
|
169381cttgggggaacaaggtcaggaaagcatgcagtttctacagcctaataagcaggcaagctg
|
169441gaaggcaagacagatcccccaaaataagggtcccattttataccagatcctggatccccc
|
169501ccaccaaaaaaggggaaatcagcccatcttccgtggaagtcttatctctcagtgggagat
|
169561aagcgggtatttccataccttcgaagtggccaagagcatgcttctctaatctaaatatgc
|
169621aaagagttaagtattcaccaataacttccactggccattccttaaagtatatttcctacc
|
169681tagttactacacaccaaagctctgtcataatacgatgtaatttctgataccaccaaaagt
|
169741caaaaacatcagatactgcaatgcaaaacagaacagagccttacattttgagaggaattt
|
169801gtcaactttcaactcctggggtttcaagaggaaaacagagtggtattttttttttttttc
|
169861caaaatggtgtctctggcacctcctgtttttcccagggagtcataggctgttagagtttg
|
169921aatatcctgctttaatgaagctgacttttaaccatagcactcttaaaaataaaaatcctt
|
169981taatgtctcttattacccaacttcagccatgccaaactaccaatatttctggcttctgaa
|
170041ctttaccaaaggcaaactcccaggtactcggagaaaaaaaattcaagacagtttgtggag
|
170101ggaaagagaatctacaaatgttcagacagatctcaaactagaaaggactcattccctaag
|
170161ctggggattgaaccctgaacctgggctgccactgtgaaaagacagtcttagctgctgagc
|
170221tacagcattgggcagtctccattgcccttcccagaaggaggctagagtcaccaattttga
|
170281gcttgcaaaggcttttatctgatcaagataatttttaggagtaactatggcatgaacccc
|
170341aaaactcctgtctgctggatggtagaaacgaagagaaagtatcgccacgtggttacaagg
|
170401tgaagctcccaaggacataaaacaagacgaaagagaaatttcatccagcttttcagggac
|
170461cttcagcaaagtttataactgatcagtttgcttggccattttgaacagcgggcttacagg
|
170521cgtcatagtgagagacaggactagctggatatcctaggcctactaagaatccctaagcct
|
170581agctgggaaggtgactgcatccacctttaaacacggggcttgcaacttagctcacacccg
|
170641accaatcaggtagtaaagagagctcactaaaacgctaattaggcaaaaacaggaggtaaa
|
170701gaaatagccaatcatctatcgcctgagagcacactgggagggacaatgataggatataaa
|
170761cccaggcattcaaaccagcaagggctaccctctttgagtcccctccctttgtatgggagc
|
170821tctgttttcactctattaaatcttgcaactgcacactcttctggtcagtgtttgttacga
|
170881ctcgagctgagctttcacttgccgtccaccactgctgtttgccgccatcgcagacccgcc
|
170941gctgacttccacccctccagatctggcagggtgtctgctgtgctcctgatccagtgaggc
|
171001acccattgccgctctggattgggctaaagtcttgtcattgttcctgcacggctaagtgcc
|
171061cgggttcattctaatcgagctgaacattagtcgctgggttccacagttctcttctgtgac
|
171121ccacggcttctaatagagctataacagtcactgcatggcccaagattccattccttggaa
|
171181tctgtgaggccaagaaccccaggtcagagaacaagaggcttgccgccatcttggaagcgg
|
171241cctgccactatcttgggaactctgggagcaaggaccccctggtaacagtaggcttgcatt
|
171301ctatcctaaggtacccttctttatggcagaacaatatagacacacaaagcacaccagatt
|
171361cgttacagcttaaggctagcctcacaagtcttttttctcattaaccaaaacttgcctgtg
|
171421gtaaggtggggaaagtgaagagctcaggaagaccagagaaagactcacctatcccagtga
|
171481cactgaatcaaaagttcaggcagccgctcattggttaagaagggatcttttccaggagtt
|
171541gcatcagctcttaagtgtccccgtttggggagcaaaaagctctcatgtcccaggatcctg
|
171601tacatacacaattctgtcacccacagccatcagcaaagatttcaaggtagattaatccaa
|
171661agagaatagcaattaatatcccatggtgctaaatccgttcttagccaagaggaactttac
|
171721tctgagaggggcttctaactccctaaatcttagaagggactctaacactcctgagttggg
|
171781cctcaaaccaaagttcagtcaagtgtccttgccttttattaagaggggcctttaacccac
|
171841tctgtcttaggagagactttaactcccctaagttgagcctctaacccaattccatccttt
|
171901acctgggtaccccgccacttaccctagatagccaattggtgctgcagtctatttcctttg
|
171961ggtagggtgtctcctcagggttcgacaggaagatgttaccagaaagggatccagatccag
|
172021accccaagagaaggttcttggatcttgtataagaaagaatttggggtgagtccatagagt
|
172081aaagtgaaagcaagcttattaaggaggtaaaggaatacagaatggctactccataggcag
|
172141ggcagtggcttgagctgctccactaaggatacttattgttacttcttgattatatgctaa
|
172201agaaggggtggattattaatgagttttccaaggaaggggtggccaattcccgtaactgag
|
172261ggttcctctcctttttagaccatttagggtaacttcctgatgttgccatggcatctgtaa
|
172321tcacggcactggtgggagtgtcttttagcatgctaatacattataattagcatataatga
|
172381gtgatgaggatgaccagaggtcactttggtcgccatcttggttttggtgggtttgggctg
|
172441gcttctttaccacaggctgttttatcagcaaggtctttgtgacctgttatcttgtgctca
|
172501cctcctagctcatcctgtcacttggaatgccacacctcctgggaatgcagcccagtaggc
|
172561ttcagcttcattttacccagcccctattcaagatggggttgctttggttgaaacgcctct
|
172621gacagacccaccagaggagcccttcagtttgtattaatatgatatgtgactacttatttc
|
172681acagacactgtgtgtcaaatgtcggtacaatgccaacaactcactttcttggttgttgag
|
172741tttccgcattacacaaataaggaagcaggcccagaggagagcctgggaaatgaagttgga
|
172801gagacccatcctggggttgcttgatttagggatttagactgggaatgactcctccataga
|
172861tctgaaagaagaaactgcacactgttcatagtggcttcttttctgccagccctaaacagc
|
172921tcaagaaaggagagtctctcagttatgaggctgggtgtgaagcattttttttttctttga
|
172981gagaggtcttgttatgttgcccaggctggtctccaaatcctgggctcaagcgatccttcc
|
173041accttggcctcccaaagtgctgggattacaaatgtgagccaccacatccggcctgaagca
|
173101tcttggttcatgcatctagcaaaccttcagtctgtgtctctcaatcccactggacatgag
|
173161gtctgcctataacaattatttggctacaacccctttaatatcctgaacttagctaaacag
|
173221ttattttaaaaatccatattcaaatataactaaagaagaaacagaggaaaagtaatttgt
|
173281aatatggatttctatttatattcgttttgactccattagcagatagcagtcactgccctg
|
173341tttgcacttgttttgaatcagtgagcctgtagctgccaagtgcagactaacaagaggtaa
|
173401ataacctgtataccttgagcagctctgactttaacttattcttttattttttatattttt
|
173461atttttttttatttttatctctttttagacatgaggtctcactatgttgtcccagttgac
|
173521ctcaaactcctgcactcaagtgatcctcccaccttggcctccaaagtactgggattatag
|
173581gtgtaaaccactgtgcctgggcttttatatattttttaagtgcacattttaatgtttagc
|
173641ttgtcagccttaagtaacgagatccagaaagcttgaggatagctacacagaagcatagat
|
173701tcaagttgtcctgaatatacacttcgattcacagcagttacaagtgagtttttaaggaaa
|
173761cagaatagttcctaagttgtttatcaagaatttaaaataaaataacataagcaattcatt
|
173821ggctatacattgttttttgtatcacaaattccaggaacagataacgggtgaggcagctag
|
173881tcagggacaaaacgccttggaacaattgtctctgggcatgggtggggagggtgtgactga
|
173941agttccatactcatgcctttctgggcctgataaattgggcatgtctcacatcatgagact
|
174001gctctgagctatttttcttttctcaagctttataccaaattctaggccgtgggctttcat
|
174061tcattcaataagtatgtattgagtgtttatgtaatcggaactcttctggggttacaattt
|
174121aacttactttctcacctccgaatggttatcacctcaacgaggactaaatccaatgatttt
|
174181tttttatcttgccaaaattcctatctaaggggtctggggagtcatgccctacaaatcata
|
174241aattctcatcagatgggttttatttaaccctatatatcatgacttactttccaacctgac
|
174301tctggcataacatgacgagacaaggaagaaaagcaaaatattttaatatttttacctcaa
|
174361aacatgtttctttgccatatcttgaaatggccctgctactgtcctttgtgggggaaaatt
|
174421ttcatctgtaaagaatctctattaacatagctggatctttttctaccaggcccttccaat
|
174481cataaagagattaactaagtgtagcaccttttatagatctgaataggaaacacttgtcat
|
174541ctgttgtttctaagggcagccactataagacttcaaaagaaccttggtctccacagtctt
|
174601ttatcttaacatttcttttctatcaaccccaggtctttagacaaactcaaccaattgtca
|
174661accataaaatgtttaaatttacgtatagcctgaaagccctgccaccccactttgaattgt
|
174721cccaccttcctggaccaaaccaatgatttttttttttttttttagatggagtctccctct
|
174781gccgcccgtgctggagtgcagtggtgtgatctcggctcgctgcaacctccgcctcctggg
|
174841ttgaagcaattctcctacctcagcctcctgagtagctaggattacaggtgcctgtcacca
|
174901cgtccagctaattttttgtatttttagtagagacagggtttcactatgttggccaggctg
|
174961gtctcaaactcctgacctcaagatcagcctgccttggcctcccaaagtgctgggattaca
|
175021ggcgtgagccaccgtgcctggccaatgtattccttaaatgcatttgattgatgtctcatg
|
175081cttccctaaaatgtatgagacatccttctcccctgattgttttcaaaagcagtgatccat
|
175141tgaggtgctcatttttgtaaccccagttactagaaaagtgcctgggtaagagtatgtagg
|
175201atctctataaaagctgaattaacgaattttgtaatgactgcacctccagacaggagctgt
|
175261cttccgggcttccacagtctctgacagccctctcccacaaagagtttaccaacagcaagg
|
175321actttcctggatgacttccactgggttggggattaaggattgaaaggggagaggctgggt
|
175381gtggaatattctggctgtgctggctgtggacttagtcctgtgtcttcccgcatccagtgt
|
175441agtctctggagaaagaatgcctgagctttaccagcaccacccaggaagcccataagaata
|
175501ttcccatctatatggattcaactggaaccactgtggagagatggtacctgcctgcaaacg
|
175561gcactttatccaggacacctgcctttacgagtgaccccccaacttggggccctggatcca
|
175621gcaggtacgcatggcttcctggcatccaagagctagcagaggagctgaattttccaggcg
|
175681tctctgcaggcagcaaccccagctccagttctattcagggctgggttcctgggattcttg
|
175741agcctgagcccttcttttctaccaaaatctcccaggtggatcagagctggcgcaaagagt
|
175801gggtgctgaatgtgcccctgtgcaaagaggactgtgagcaatggtgggaagattgtcgca
|
175861cctcctacacctgcaagagcaatgggcacaagggctggaactggacctcaggtgagggct
|
175921ggggtgggcaggaaaggagggatttggaagtgaaggtgtgtgggtgtggaacaggtgtgt
|
175981gacattttggggttgtagggctggcagaatcagagaccctttggggcccagtggctaaag
|
176041gtcttccctcttccctacagggtctaacaagtgccaggtggcagctgcctgactaccttt
|
176101ccatctctactttctcacacccactgctctgtgcagtgaaatctggactcactcctacag
|
176161ggtcagcaactacaaccgagggagcagccgctgcatccagatgtggttcgacctggccca
|
176221gggcaaccccaatgaggaggtggcaaggttctatgctgcagctctgagtggggctgggcc
|
176281ctgggcagcctggcctctcctgctcaacctggccctaatgctgctgtggctgctcagctg
|
176341acctccttttaccttctgatacttggacatccctgccctgtttagccccacagctcccaa
|
176401ctatttggttcctcttctatggtcttgtctctgacagccactttgaataaaccagacacc
|
176461acacatgtatcttgagaattatttgggtatgaatgggaatgtggctgttttgtttcccat
|
176521ttcttattgattgaagccagttagactgggctagttcccagctctgatgcttgctatgaa
|
176581ctagcctgatacttaagtattcttctaaggtaggagacatttgtagctctcgattttatt
|
176641attcactatagctccaatttagagccaagcccaggcatttttctttttttgagacagggt
|
176701ctcactctctcacccaggttggaatggagtggcatgatctcagctcactgcaacgtctgc
|
176761ctcgtgggctcaagtgatcctcccacctcagcatcccaaatacttgggactacaagcatg
|
176821tgccaccacacctggctaatttttcaattttttgtagagaggaaatcttgcaatgttgtc
|
176881caggctggtctcaaactactgggctcaagcaatcctcctacctcagcctcctgagtagct
|
176941gggtctacaggtgtgagcctccacattcagctaatacatataatataaaacatgtattat
|
177001atatgtaatagtagagacagggtctcactattttacccaggttgttctcaaactcctgcg
|
177061ctggagtgatcctcccaaaatgctgggattacaggcatgagtcactgcatctggccacaa
|
177121gtcatgtttatttcttgctcaagctacaatgctgaatgtgggttatcagggggattctgt
|
177181ttatttctcattcctggactacattagcagccagggggttctgcttctcactcaagaacc
|
177241cacgctgatggaggctccatcttccatgagacaggaagagggaacttggcaaattccata
|
177301aggctcttcaaatttccacccatcacttatttcattggccaaatcaagtcatgagcatgc
|
177361ctaaattcaagaaagccaggaaaacataatcctatcatgtacttgcaaggagaggggaat
|
177421cacaaggtttgcaacagacctaatcatgagtaaaaagacttcattattttctcgtagatt
|
177481tctgtttctggcatggtcatagttacaaatttaattttttggttagatcctagtaagaag
|
177541gaggaccaactctctatacatatgcaaataactacatcaacctgaaaagtggagcaatcc
|
177601actgatgaccgccctggctagtcttgtaaacaaggccaattgatgccttttcgcccttca
|
177661tttatttctatttattatttttattttttgagacagggtctctttctgttgctcaggctg
|
177721gagtgcagtggcacagtcatggctcactgcagtcttgacctcctgagctcaattgatccc
|
177781tcaactttagcctcccaagtagctgggactacaggcacatgccaccatgctgggcaaatg
|
177841ttttgtattttttttgtagagatggggttttgccatgttgcccaagctggtcttgaactg
|
177901ctgcgcccaagtgattcattcacccaccttgacctcctaaagtgctgggattagaggcgt
|
177961gagacacctctgccagcccactgatttcttttttgaaccgaaagcatagttgatcaatgc
|
178021aaaagctaataattggatattaacaaaattcaaaactcttgcactttaaaagacaccctt
|
178081aagaaaattaaaaaacaagcaacagactggaaggaaatatttgcaaacacatctgataaa
|
178141ggatctgtatccataaaatacaaagaacacttacaactcagtaacaagaaggcagacaac
|
178201ccaatcaaataatgggcaaaagaaatgaacaaatatgtcattaaagaaggtacacaaatt
|
178261atgaatagttacacgaaaagatgctcaacattattaatcattagaaaaatggaaactaaa
|
178321accatagtgatagacggttttatacctactagaatggcaataataataatgataggcaat
|
178381aacaagcattggcaaggatgtggagaaatgggaaccctcacacagtgctggtggggatgt
|
178441aaaatggtacagcccttcggaaaacagtgtggcagtttctcaaaaagttaaatgtaaaac
|
178501tgccatacaacccaaaattccactcccaggtgtctactcaggagaaacgaaaacaaacat
|
178561aacaaaacttaaatatgaatattaataataatcatatttatgtatgtaaatatgatgtat
|
178621catttatgtatgtaaatatgatatatcatattatgtatcattatatataatagccccaag
|
178681ctggcaataacctaaatttttagcagctggtgagtagatagacaaaatgtggtgaatcca
|
178741tacaatagaagactgtgcagcaatgaaacgtgatgacacatgctatgtcgtggatgagcg
|
178801tcaaaaacattatgttaagtgaaagaagccagacctaagaggcttcatgtggcatgattt
|
178861cacttacatgaaatgtgcagggaaggcaaatttatagaggcagaaagtagattagtagtt
|
178921gcctggggctggaagtgacaacagggattaattgtaaatgggcatgaggggggataagaa
|
178981ttgaggggatgattctgagtttctgtggggtgtatccatgagggaaagtattctaaggaa
|
179041attggcatgtggctccataaaaatctatcatctgagacaaactccattcccatcatgaac
|
179101tttaaaatattggttggaagccaagcatggtggctcatacctgtaattccagcactttgg
|
179161gaggccaaggcaggtagatcacttgagccagggattctagaacagcttgggcaacatggt
|
179221gaaaccccgtctctacataaaaatacaaaaaatttagcccagtgtggtggtccacgcctg
|
179281tagtcctagctatgcaggaagctgagatgggaggatctctttagctcaggaggtagaggc
|
179341tgcagtgggctatgactgtgccactgcagtccagcctgggttgatagagtgagaccctgt
|
179401ctcaaaaaaaaaaaaaaaaaaaaataggaattgctggatggtaatgttgtaggagtttct
|
179461cctcagttcagccaaagacagggtccttgtcacctggccatgaaatattaggcttgcaga
|
179521cactttgaagggtgagaaaaatggaatttattgggcaaaaaaaaaaagcggggaaacggg
|
179581gaccctcggcagagtgagagtcctgctagtacacgcttcccacctctcaggttgaatccc
|
179641aggttccaccctggaagaggaggggccaggctcctcagcacgaacttccagaggctccac
|
179701cccagtgcacattcctcccagtgtgcgggtttgtcagaggttctctggggacccctttac
|
179761acttggctgtctcattcccccctctcaagaagtacatcaaactactgttagaacaaggat
|
179821aggggtgaggacgaagaccgatctaaactgcttcctgctaacagggagcggtgttttggg
|
179881aaacggcagtcagagctccctcagaagcctatctaagggttcccggcagaaggcgccatc
|
179941ttccgaggctccggttgcacgaccatttggagtttgatggcctgaaggcaagaggagaaa
|
180001aaccaggttattagaaaacatgtgttaaaacgaaacaagggagggtaaggacagcttaaa
|
180061atccctaggccttttaccagtttgcacagggagagggaaaccaaaagcccgactggtaaa
|
180121aaaaactttacccttttgccagcatgtcatgcttgtgggttcccttcctctgagcccaat
|
180181cctaagccaaccagctgaaggtttgggaaattaactctttccagtttggaggatgcatct
|
180241gaggggagtgtcctatagtacaaagacacaattacctattagtgaagagaagacagtgga
|
180301gaagaaaggaaaaaaaggtgctttttaaaggagtcccaggggttcagcatgcattcaaaa
|
180361ggggtacagagtgaagatgaatggctacccatctagaaagaggggagcaggcatccctgt
|
180421ctcctatctctttctagcagataccaggggtacatgagggagagaaggaagagcgtcctc
|
180481tttccctcttctgtccttgcatacccaagtcctggtgaccttggcaggtgctgccatggg
|
180541tgccacagcagcttgcacccatgaagcagggagtacctagagaataggaattatcagcca
|
180601gactcagtggctcacgcctgtacaacccagcaccttgggaggccgaggtgggcagatcat
|
180661gatttcaggagtttgagaccagcctggccaacatggtgaaaccccgtctctactaaaaat
|
180721acaaaacttagctgggtgtggtggtgcatgcctgtagtcccagctactcgggaggctgag
|
180781gcaggagaatcacttggtcccaggaggcaaaggttgcagtgagccaagatcacaccactg
|
180841cactccagcctgggcaacagagtaagactccatctcggggaaaaaaaaagagagaatagg
|
180901aattatccgctcttacctatgtttctataccccctacagtcagtagtcttggagtttcct
|
180961agacctcatttatgctgtggggaaaagcaagagagatcagattgttactctgtctgtgta
|
181021gaaagaagtagacataggagactccattttgttatgtactaagaaaaattcttctgcctt
|
181081gagattctgttaatctataaccttacccccaaccctgtgctctctgaaacatgtgctgtg
|
181141tcaactcagagttgaatggattaagggcggtgcaagatgtgctttgttaaacagatgctt
|
181201gagggcagcatgctccttaagagtcatcaccactccctaatctcaagtacccagggacac
|
181261aaaaactgcggaaggccgcagggacctctgcctaggaaaaccagatattgtccaaggttt
|
181321ctccccatgtgatagtctgaaatatggcctcgtgggaagggaaagacctgaccgtccccc
|
181381agcccgacacccgtaaagggtctgtgctgaggaggattagtaaaagaggaaggaatgcct
|
181441cttgcagttgagacaagaggaaggcatctgtctcctgcctgtccctgggcaatggaatgt
|
181501ctcggtataaaacccgattgtatgctccatctactgagatagggaaaaaccgccttaggg
|
181561ctggaggtgggacctgcgggcagcaatactgctttgtaaagcattgagatgtttatgtgt
|
181621atgcatatctaaaagcacagcacttaatcctttacattgtctatgatgcaaagacctttg
|
181681ttcacgtgtttgtctgctgaccctctccccacaattgtcttgtgaccctgacacatcccc
|
181741ctctttgagaaacacccacagatgatcaataaatactaagggaactcagaggctggcggg
|
181801atcctccatatgctgaacgctggttcccagggtccccttatttctttctctatactttgt
|
181861ctctgtgtctttttcttttccaaatctctcgtcccaccttacgagaaacacccacaggtg
|
181921tgtaggggcaacccacccctacatatgccatggatactagcatgacctttatccatgaaa
|
181981tgggaggcttggcttgattggcaggaattagccatgctcacttgcacgcactgtgccttt
|
182041tttttttttttttttttttttttttttgagacagagtctcgctctgttgccaggctgaag
|
182101tgcagtggagtgaactcggctcactgcaacctccgactccctggttcaagtgattctcct
|
182161gcctcagcctcctgagtagctgggattacaggcacgcaccaccatgcccagctaattttt
|
182221gtattttttttttcgagatggagtcttgctctgtcgcccagtctggagtgcagtggcatg
|
182281atctcagctcactgcaacctccacctcccagttcaagcgattctcctgcctctacctccc
|
182341aagtagctaggattacaggtgcatgccaccatgcctggctaatttttgtatatttagtag
|
182401agacggggtttcaccgtgtttgccaggatggtcccgatctcctgacctcatgatctgccc
|
182461gccttggcctcccaaagtgctgggattacaggtgtgagccactgtgcccggccttgcact
|
182521gtgccttttaacccctgttatcatctgcctctgaatcccttagatccagttttctttcct
|
182581ggggctttgactcaaagcttggaatagaatttgaaacaaaaatatgtgtctaggaagggc
|
182641tgcatggactccttatcataagccaaatgctaaggaaggtgaagctgcagaattgagtcc
|
182701tcctccaacaagggagagaaaaagatgtcttgtgacatgcccagataattggtggctata
|
182761gttatgtaagctaggatttgggtgcatggtgcttggctttggttagctcttactttccaa
|
182821aaaaggaaacctccgattaatgggcatcctatttattcccatcacctggcaggatttgca
|
182881ggataattgctcagaactaaaatattgatccagatttttacattacccatcctctccttc
|
182941tttctgagctgcagctggagattgctggttggttcacaggaacaaggagtgttagcctaa
|
183001aaatgtaggcaaaaacttaaacactaatgactttagaatttattgacaaatgtatggtgt
|
183061tttgaaacataatttctctctctccagtcctcatttttgttaaaaaagcaaattatggta
|
183121ggattgagttgtttgcaaaatagactttagtcatatacttggcctgattatttgcataaa
|
183181gtgcagcaagaataactatttctacataagtcttttagattggctttgatggaactctgt
|
183241tcttcaaggaatttcagacaaaacgttttaaaactgagcccagccatggatttgtatcct
|
183301caaatacctgtaagttggatgatcttctcgtgttaaggtcccatgacaaatttggagctc
|
183361ctagacctgttagaaagtgacattcttggccaggcgtggtggctcacacctgtaatccta
|
183421gcaccttgggaggccgaggtgggcggatcaccggaggtcaggagttcgagaccagcctgg
|
183481ccaacatggtgaaaccctgtctctacttaaaatacaaaaaattagctgggtgtggtggca
|
183541agtgcctgtagtcccagctatttgggaaactgaggcaggagaatcacttgaacctgggag
|
183601gcggaggttgcagtgagccgagatcatgccactgcactccagcttggcgacagagcaaga
|
183661gtctgcctcaaaaaaaaaaaaaaaagaatactcacggataatttccaaattctggagaag
|
183721ccaggcagagagagagaaaaatatgcttcaaattttgttcacaggagtgtagcttactct
|
183781agtattaaaggccttaaagagttcaaaataattttccttgactctgagaaacaaaacaag
|
183841gatcagcaatattccaagcaaaagtcaaaaaggttgcttcagctttctgagttcagtcca
|
183901ttcagttcttgttatgcttgatattcgtgaacattttagctcttcatgagtcctgtacat
|
183961tttcctttattccaatatcacagtctccaaagttatcagaaacctgtatttgagagcacc
|
184021tgtcagagtcctatagcttattacaaaccaactttatttttttttgagacaggatcttgc
|
184081tctgttgcccaagctggaatgcagtggtgagatcttggctcactgcaacctccacctcct
|
184141ggattcaagcgattctcctgccccaacatcctgagtagctgggattacaggtatgtgcca
|
184201ccatgcccggctaatttttgtatttttttttttttagtagagatggggttttaccatgtt
|
184261gaccaggttggttttgaactcctgacctcaggtgatacccctgacttggccttccaaagt
|
184321gctgggattaaaggtgtgagccactgcacccagccggatcaggcacttttaacttgaaaa
|
184381catgaagttctctttcctaacttttttctttctttcttttttttttttttttccgagaca
|
184441ggatctcactctgtcacccaggctggagtgcagggatgccatcacagctcactgcagccc
|
184501tgacctcctgggctcaagcaatcctcccagctcatcctcccaaatggctgggactatagg
|
184561cttagaccaccatacccaactaatttttgtatttttgtgtgaagatgaggtctccctatg
|
184621tttcccaggctggtcttgatctcctgggctcaagcaatccatcagccttggcctcccaaa
|
184681gcactgggattataggcatgagccaccaaggacggccccctaatgttttttatattggct
|
184741aatgagctttaagtttatacatacaaggcataaagaaataactttaaagttatgttatta
|
184801gatgtacagtgatatgatttagctctgtgtccccacccaagtctcatcttgtagctccca
|
184861taactcccatgtgttgtgaaagggacctggtgggagatgattgaatcgtggaggtgggtc
|
184921tttcccgtgctgttctcatgataatgaatgggtctcacaagatctgatggttttaaaaac
|
184981gggagtttctctgcacaagctctctctttgcctggtgccatccacataagatgtgacttg
|
185041cttctccttgccttccaccatgattgtaaggtctccccagccatgtggaactgtaaatcc
|
185101aataaacctctttcgtaaattgcccagtcttgcatatgtctttatcagcagcgtgaaaac
|
185161agatgaatacagtaaatttgtactgggagtggggcattgctgaaaagatacccaaaaatg
|
185221tggaagcgactttggaactggggaacaggcagaggttggaacagtttggagcgctcagat
|
185281gaagacaggaaaatgtgggaaagtctggagcttcctagagacttgttgaagggccttgac
|
185341caaaagcctgatagtgatatggacaataaggtccaggctgaggtggtctcagatgaagat
|
185401gaggaacttgttgggaactggagcaaaggtaactcttgtatgttttagcaaagagactgg
|
185461cagcattttgtccctgccctagagatttgcagaactttgaactcgagagagatggtttag
|
185521gctatctggtggaagaaatttgtttattattattattattattattattattattattat
|
185581tttgagatagagtctcactctgtcacccaggccagaggacagtagcgtgaccttggctca
|
185641ctgcaaccttcgcctcctgagttcaagcgtttctcatgtctcggcctcccaagcagctga
|
185701gataacaggcatgtgcctccatgcctggctaatttttgtattttagaagagacagggatt
|
185761caccacattggccaggctggtctcaaactcctgacctcaaatgatccaactcagcctcct
|
185821gaagtgttggaattacaggcatgagccaccacacctggctgcggaagaaatttctaagct
|
185881gcaaagcattcaagaggtgacttgggtgtggttaaaggaattcagttttataagggaagc
|
185941agagaataaaggttcagaaaatttgcagcctgacaatgcgatagaaaagaaaagccaatt
|
186001ttctgaggagaaattcaagccagctgcagaaatgtgcataagtaacaagaggaacattaa
|
186061cccccaatacaatggggaaaatgtctccagggcatgtcagaggtcttcttggcagcccct
|
186121cccatcacaggcccagaggcctaggagaaatggttccgtgggccaggtccagggtccccg
|
186181tgctgtatgtagcctagggacttggtgccttgtgtcccagctgctccagccatggctgaa
|
186241aggggccaacatagagcttaggccatggctgcagagggtgaaagccccagtccttggcag
|
186301cttccacgtggtattgagcttgcaagtgcacagaagtcaagaattggggtttgggaacct
|
186361ccacctagatttcagaagatgtatggaaatgcctggatgcccaggcagaagtttgctgca
|
186421ggggtggggtgctcatggagaacctctgctagggcagggcggaagggaaatgtggggttg
|
186481gagctcccacacagagtccttactggggcactgcctagggcagctgtgagaagagggcca
|
186541ttgtcctctagccccaagaatggtagatccactgacagcttgcactgtttgcctggaaaa
|
186601gctgcagacactcaatgccagcctgtgaaagcagccgggagggaggctgtacactgaaaa
|
186661gccacaggggcggagctgccagagaccatgggaacccacctcttacattagtgtgacctg
|
186721atatgagagatggagtcaaaggagatcattttggagctttaagatttgactgccctgctg
|
186781gattttggacttgcaggggcctgtagcccctctgttttggctaatttctcccattttgga
|
186841gtggctgtatttacccaatacctgtactcccattgtatccaggaagtaactaacttgctt
|
186901ttgattttacaggctgataggcagaagtgtcttgctttttctttgctgagactttggact
|
186961gtggacttttgagttaattctgaaatgagttgagactttgggggactgttgggaaggcat
|
187021gattggttttgaaatgtgaagatatgagatttgggaggggacagggatggaatgatatgg
|
187081cttggctgtgtccccacccaaatctcatcttgtagctcccataattcactcatgttgtgg
|
187141gagggacctggtgggagatgattgaatcatgggggtgggtctttcccatgttcttgtgag
|
187201agtgaatgggtctcacgagatctgatggtttttaaaacaggagtttctctgcacaagctc
|
187261tctctttgcctgctgtcatccacataagatgtgacttgctcctccttgccttctgccatt
|
187321attgtgaggtctccccagccatgtggaactgtaagtccaatgaacctctttcttttgtaa
|
187381attgctctatctcgggtatgtctttatcattcctgaaaatggactaatacatacggcaat
|
187441actcaagagagcaagtgtggatagcttgggttcatgaggtttttggtttttgtcaaaagc
|
187501ataaatgtatactgaaactacccagaaaaagcaaagtataaaacagtatgctaccatttg
|
187561tgcccataaatgggatatgtgtagtgtaaatgcatagaatttgaccagatgtatacccag
|
187621agaccagaacactcagtggcctcatgttcatactttggcaaacacatgtatagtatcctt
|
187681aacttaaatgtaccattgttgtgtgcattctagtgttattgacatttacatatctattat
|
187741caagtcagataaatcattctgtgtctttgtattttcacttcctattttgtatatttatgt
|
187801atacatacacacataccaatacatatttaaataaggtataacttcacctggtccaaaaat
|
187861caaaacaacgtagaaaggtttacagtgaaaggtcgcatccctgatgctgtcctcttcccc
|
187921caggtgatcaccttattggtttcttttcatacctttcagcattttctcctgcaagcacag
|
187981atattctaactcctccttttttacacagaatttttttttacatagcattcttctgcacct
|
188041tccttctcccacttcacaatgcacatggagatttttccgtatttgtacatcaggagcttc
|
188101ctctttctttgttaccacattaaattccactgggtagatgtaccataatttaactgggtc
|
188161cttattgaaagacaattgagctgtctcctagacaaagccttgtgcaccttcccgaacaga
|
188221gggtctaaccaagcaggcaggatggggttataaagtaggtggggaggtgggagagactcc
|
188281accctcccaggtgggctgaggatggaggtaaggccctgcaacaggacagagggaaaagtg
|
188341gggatgagacatgggaggcgagatagcgctcactgttctcgctcagccccctcctccatt
|
188401tgccgctgacctgttggcctcccccaacctctgagcctgcctctgcctaggtaatttccc
|
188461aagacccaggaggggtgaagggtgaggtgcgattgcccccacctccttgcctcccgcagc
|
188521atctgctccaggaccatgaacaatagctgacagctccatggcccttgctgtccccatctc
|
188581agcttccctgggcatctaaacctcagttgccRtggggtaggaggacaggctgaggaagca
|
188641gaagcctgaggctgtctagagtctcactcctgcatcagcaggccaccacctgtggttcct
|
188701ccttgtgcaaatttgagaggaattgcataaaacactggagaaatccaagaggggaagtcc
|
188761acaagggcggtggctccctccatgatctcagagcaagctggtgtcagaacctggacctag
|
188821agcactgttgggtgggaagtaggaggagagtcctgcctccaggccagccggggaagggct
|
188881ccctctcacctctacacgcagcgcatttcttggctcagctgccctgtaggggatgcaggg
|
188941tggggacagcagagatctgggcctgggagggagacagtacacaatcacatggctgttgcc
|
189001cctccctcaggccttgtctacctctgactgtggctctctggcaggaatagatggacatgg
|
189061cctggcagatgatgcagctgctccttctggctttggtgactgctgcggggagtgcccagc
|
189121ccaggagtgcgcgggccaggacagacctgctcaatgtctgcatgaacgccaagtaccaca
|
189181agacacagcccagccccgaggacgagctgtatggccaggtgaggataaagtcgggtctgg
|
189241ggcaggggagagagctgcctttgacagagaaaagttagcagggtgaagtcagctgtggaa
|
189301ggtgatgaaggcagaggatgactgctgtgatcctggagggcctcccctgggaggacacca
|
189361aatctacaataataaaggaaccacatacctaacacccactatgagcctatgagccttgtg
|
189421ctttcactcatgccatgttagtgaatatgcccaaagggcagggtgggtgcgtggtagtct
|
189481ctacttacgcaaatgaggaaataggcccagagagggcgcaggtgcaagtgggaaatgagg
|
189541agagggactgtccatacctttcccagccttaattgtgtgccagcccacagagctcaatgg
|
189601cacagtagaagaggagctgggcccatcatggtcatggtgcagcctacatgtacaaacagt
|
189661ccaggtttccacccccattaggtactgaagagacaacgaccaatccaatatgctggggag
|
189721acttcccaggcaagagaccattggccttgacctgggaagatgagtaagagttttctagga
|
189781ggaaaaagcgggaaagggcagcctggtagaggacagcatgcacacaggtcagagggtgat
|
189841ggcacgagcaatggcgggtccagtgtggccagagccagcggtgccactgcccacaaggaa
|
189901ggggaggggaggccagggccctcatgccacaggtaaggccactgaggcagctcggggagt
|
189961atgagctccaatttgaattccaagctcaggagagtgcctgtatttcatttctctggtctc
|
190021ctggcctgctccctagaagggttcacattcccagagggtgaggatgtgcccagggagaga
|
190081ctgtggcatggacaggctccgagggctaaagcaaagagaggacagcctggaagccctgtg
|
190141acatctgagtcattcccaacattccatttgcttattttaaaatcagggtaaaatttaaaa
|
190201taaataaataaaataagttctccattttagccatttttaactgtacaggtcagtggcatt
|
190261aagtatgctcatgtatgccgggtgcagtggctcacgcctgtaatcccagcactttgggag
|
190321gccgaggtgggcggatcacctgaggtcaggagtttgagaccagcctgaccaacatggaga
|
190381aaccctgtctctactaaaaatacaaaaaaaaaaaaaattagccgggcatggtggcccatg
|
190441cctgtaatcccagctactcgggaggctgagacgggagaattgcttgaacctgggaggcag
|
190501aggttgcagtgagccgagatcgcgccattgcactccagcctgggcaacaagagcaaaact
|
190561ctgtcaaaaaaaaaaaaaaagtatgctcatgtggttgtgcaaccatcaccaccatccatc
|
190621tcctgacctctttcattctccaaaactgaaatggaaactttgtgcccaccacttcatttg
|
190681cttttcagaaccttctaaagcacctactctttgccaagaaatggtgcagatgtagacttt
|
190741gagagatacagatgattatcattctcagggccatgagctatatgagagtgatgatatttg
|
190801ttgggccacttctatagccagggagtacttttcattatattcagtaactctttcagaggc
|
190861agaaacccctgaccctgactggcaaaacccatgtctgccaaaccccaagacccatgatgt
|
190921gcaaggggtcttgcaggaagaccaagagttgggacagccaaggaaaagcaagtgtgaagt
|
190981tgtgctggcggggaagcatgttctgtgtcggccggcactgggcgtggtggcccagtgggt
|
191041aggtctggctccactcccatggatttccctattgtttctcctggttgctcagacctgtca
|
191101cgcctctgccatcacttgaccctaggtgcaagggttcagcccagaaatKttatgcaattg
|
191161actcatgatttctcaggttttctgcatcctggcctagagtgatttccaaagaaaaacctc
|
191221caccatttctgcttgtcttgcctgcattgtatttacctttctaggattgccttttccaca
|
191281tttagtcaagcccgggttcaggcccacgttcaggctacagctcctctgttcccccaccac
|
191341tctcaggatc
Following is a NUMA1 region genomic nucleotide sequence that includes the NUMA1 SNP “NUMA1-AA” (SEQ ID NO:).
|
TCTCTGCCCGACTACAGTCTACTAAACCTGAAGCCCACATGCCCTTCAGTCCACATCCGTAGTGGCCTTTCCCTGACCAGCTCCTG
|
CCCTATCTTTGCCTTCTTTGAGACCAGACACAAAGTGTCACACCCTCTTTGCATGCACAATCTCCCGTAGGAGGAAGGGAACCAAT
|
CCTCAGGGAACACCCAGGTGCAGAGCCT[-
|
/T]ACTCTAAGGCACTTGGCATGTGAGCTCTCTTAGGACAGGGGAACTTGTTTCTCCTCAAAGCCACTCTGAGAAGTCACTTCACC
|
CTCTTTTCAGAGGAGGAAACTGAGTTCAGAGATTTAAGCAAATTGACCAGAGTAACAGTGACTAAATGGCAGAGTAAGATTTGGTC
|
CACCTAACTCCAAAAGCCCATGGGGGCTTAT
Following is a NUMA1 region genomic nucleotide sequence that includes the NUMA1 SNP “NUMA1-AB” (SEQ ID NO:).
|
AAACCAATCACAGCCATCACACCTCTAATTCAGAACTACAAATCAACATTTAGGGTCACAGCCCAGTACCCGGGAAGCCGCCAATT
|
ATGGGATAAGGAAAGGGGCAAAATATGCAGGTCTCTGGAGAGACTGAAGCATAAGACAGGTGCTGGGACATTCTTCTCAACCCTCT
|
CTTGGGGAGCCTTCCAGACCACCTCAGCCCTGAGGGGCCTCCATGCACACACCACCTTAACACCCACCTTAAAGGAAAGGTCTCCA
|
TTCTCCTCCGAAAGCTGGTTGATTTTGCGATCCATCTGGCTCTTCTCTGTCTTCAGGTCCTGGCACTGCTTCAGGGTTTCATGCAG
|
CCGCATGGTAAGGCTGCGAGCGAGGGAAGCAGTGAGAAGAGAGTATGGG[T/C]TCCTGGCTGGGTGAGGGGAGGGGCTGGGGCCT
|
GGGAAGGAATGCAGGGAGAGCTGTACCTCTCATTCTTGTCACGCAGCTCCTCAAGCTCCTTGGGCTCCAGTGGGCTGGCCCCCTGC
|
TTCTCATTCAGCAGGGCTAGGCGGTCAATGCGCTGCTGCATCATGGCTATCTGTGCATCTGCCCAGAGTGGAGGGAGGAGGAGAGG
|
AGAATCAGAACTATGTGCATGAGCGGAACTATCTGCACAGAACTATGTGCACAAGGGGAAGGGAGGAGACGGCATAGGGAAGAGGA
|
GGAATATGGTATCCAATCTAAGGGAAAGAGAAGATGGGGACAAAGACAGAACCTAGCTTCCAGGAGG
Following is a NUMA1 region genomic nucleotide sequence that includes the NUMA1 SNP “NUMA1-AC” (SEQ ID NO:).
|
AGACGGCATAGGGAAGAGGAGGAATATGGTATCCAATCTAAGGGAAAGAGAAGATGGGGACAAAGACAGAACCTAGCTTCCAGGAG
|
GTCAGCCTGACCACAGGCCCAGGGCTGAGCTCTCAGCTCCAGGGGCCAGCAGAGGGGACAACATGGGAGGCCAGGGGACATCCTTC
|
CGGCAAGTCTATTCACACATCTGCCAGTGTGCCAGCCACCTACCCTTCTCGGTGAGGAGCTTGCGGTTCTCAGCTAGCTCCAGCTC
|
CAGCTCATCCCTATTACTTCTCTCATCACCAAGCTGCTTCTTCAGCCGTCTCATCTGGAACTGTGGGGTCTGCAGGATATCACCCA
|
TGGGAGAAGCTGGAGAACCTGAGAGAAAGCTGAGGAGGGAGAAGGCCCATATGCATTGGTAAGCGCCTAAGAT[C/G]TGAAGCAA
|
TCAGCAACAGGCAGCAGTAAGGGAGCGGGGTCTATGGAAGTGCGCACTAGCAGCTGGGAGGCCTGTGCACCTGGGTTGTTTGCAGT
|
GCTACCTCAAGCCTCATGACATGATCTTGGGAAAACTTTTCTTCTCACTGCCTTAATTTCTTTGTCAGAAAAAAAAAAAGTGATAT
|
ATTCTCCTTGGCTCTGCAGAGATGTGCTAAGAGAAGAGACTTCATTGTAGTCTCCGAGGAAGAAGGGTATTCCATAAACAGGGAAC
|
AGCTTTTGAGGGAGGCCTTCTGCACATGACAAATCCCAACCACTTCC
Following is a NUMA1 region genomic nucleotide sequence that includes the NUMA1 SNP “NUMA1-AD” (SEQ ID NO:).
|
GCCTGCTACCACATCGAGCTAATTTTTTTTTTTGAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCGG
|
CTCACTGCAAACTCCGCCTTCCAGGTTCACGCCATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGACTATAGGCACCTACTACCAC
|
GCCTGGCTAATTTTTTGTAT[T/G]TTTAGTAGAGACGGGGTTTCACCATGTTAGCCAGGATGGTCTCCATCTCCTGACCTTGTGA
|
TCCACCCACCTCGGCTTCCCCCAGCTAATTTTTTATATTTTAGTAGAGACAAGGTTTCGCCATGTTGGCCAGGCTGGTCTTGAACT
|
CCTGACCTCAGGTGATCCGTCTGCTTTGGCCTCCCAAAGTGCTGGGATTAGAAGCGTGAGCCACCACGCCCAGCCTTTTTTTGTAT
|
TTTTAGTAGAGATGGGGTTTCGCCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCTGCCCACCTCAGCCTCCCAA
|
AGTGCTAGGATTACAGGATAAGCCACTGCACCTGGCCAGCTCTAGTCTTATTTTGCTGAAAAAGGGAGGCAATTGAGGGAAAGGCC
|
TGCTGGCCTGGGACACTGGAGACGTGGGTTTACCACACAGCCTTGGGAAATTTATCTAACTCTCTGGGCCCCTTTGTACTTTTCAG
|
CTTAGAGATTTGGGGGTTAAAGTAGATCAGTAATTTCCAAACTCTTCACAGAGTACCAGGGTCTGTAGAGATGCCTCACAGGCCTC
Following is a NUMA1 region genomic nucleotide sequence that includes the NUMA1 SNP “NUMA1-AE” (SEQ ID NO:).
|
CACACAGCCTTGGGAAATTTATCTAACTCTCTGGGCCCCTTTGTACTTTTCAGCTTAGAGATTTGGGGGTTAAAGTAGATCAGTAA
|
TTTCCAAACTCTTCACAGAGTACCAGGGTCTGTAGAGATGCCTCACAGGCCTCCATGACAGGCCAAGAAGATGGCCTATGATCTCT
|
GAAACCAGCCCCCACTTCAATCAGATCAAAGTAATTCCATTCTGTTTTATATGCTGGGATTCTGCTTAAGATTTCATTTGATAAAA
|
AGAATCTTCTGCTTAAAAACATTTGCTTGCTGACTCCATATTAGGTATTCCCAGAAGAGCCTGGTCTGCTTTCTCTCTCCACCCCC
|
CAACCCGCCATGTCTCCCTTCACCCCCAGGGGCTGTTGGTAATTCCA[T/C]TGAGTCTGAGGCAGGGCCCCCAAGAATCAAAGCT
|
GCCTCAGATTCAGGTCTGTTCAGCTTTGACAGTGTTCCCATCATCACTGGACAAGGGACAAGAACAGTCTCATCCAGTCTGAGGTT
|
AGCCCAA
Following is a NUMA1 region genomic nucleotide sequence that includes the NUMA1 SNP “NUMA1-AF” (SEQ ID NO:).
|
TCCAAGGAAAAGCAAGTGTGAAGTCGGGCTGGCAGGGAAGCATGTTCTGTCTCAGCCGCCACTGGGCGTGGGCCACGGTGTGGGAG
|
GTGGGTAGGTCTGGCTCCCCTCCCATGGATTTCCCTATTGTTTCTCCTGGGTGCTCAGGCCTGTCACGCCTCTGCCATCACTTGAC
|
CCTAGGTGCAAGGGTTCAGCCCAGAAAT[G/T]TTATGCAATTGACTCATGATTTCTCAGGTTTTCTGCATCCTGGCCTAGAGTGA
|
CTTCCCAAGAAAAACCTCCACCATTTCTGCTTGTCTTCCCTGCCTTGTATTTACCTTTCTAGGATTGCCTTTTCCACATTTAGTCA
|
AGTCTAGGTTCAGACCCACGTGCAGGCTATAGCTCCTTCGTTCTCCACCACTCTCAGGATC
Following is a GALE genomic nucleotide sequence (SEQ ID NO: 5).
|
>1: 23536001-23622950
1ggcaacctag tgagaccttt tctctacaaa aaataaaaat
aaaaaaatta gctgggcatg
|
61gtggcataca cctgtagtcc caagctgagg caacaggatt
acttgagccc aggaggtcaa
|
121gactgacagt gagccgtgaa tgtgtcaggg cactccagcc
cgggcaacag agtgagaccc
|
181tgtctcaaaa aaaaataaag taagggctgg gtgcRgtggc
tcatgcctgt aatcccagca
|
241ctttgggagg ccgagacggg cggatcacga ggtcagaaga
tcgagaccag cctggctaac
|
301acggtgaaac cccatctcta ttaaaaatac aaaaaaaatt
agccgggtgt agtggcgggc
|
361gcctgtagtc ccagctactc aggaSgctga ggcaggagaa
cggcatgaac ccgggaggca
|
421gagcttgcag tgagccgaga tcgcgtcacc actccagcct
gggcgactga acgagactat
|
481actgagtaga ctatacttgc tgcaaaaatt caaaaaagtg
tacggagcag atgagagcct
|
541ccttgcccat cctcctcccc tagtatagcc ttgaattcat
ctcccaaaca gaataggatg
|
601ggtcttttag ttactctcgc agagggctct gtagtgctga
taagagagct gaggagcccc
|
661tcttaggttt tcagatgaca cgtcaggcta gccttatatt
taataattta aatttaataa
|
721taattatttc agttttcaag aaacttactg aatctcacct
atgtgctaaa tgttgctgat
|
781tgaagatggg taaatagcct ctgaccttag ggatctcatt
cctgtgttga acactcgtgt
|
841gtaaaccaag ggttacaatg gtaatccccc agtgaataca
tacagagtac caattttaga
|
901agtggttgaa aagttttttt aaaaaatcag agaattacac
atgtataatt agctgctcat
|
961cctagaagtc atatatccag accaggcgtg gtggctcatg
cctgtaatcg cagcactttg
|
1021ggaggctgag gcgggtggat cacttgaggt caacagttcg
agaccagcct ggccaatatg
|
1081gtgaaacccc gtctctacta gaaatacaaa aattagccga
gcgtagtggc gcatgcctgt
|
1141agtctcagct actcgggagg ctgaggcaga agaattgctt
gaacctggga ggcagaggtt
|
1201gcagtgagcc cagatctcgc cattgcactc cagcctgggt
aacagagtga gactctgtct
|
1261caaaaaaaaa aaaaaaaaaa agtcatatat ccaaatgtaa
gagtactttg caggtaagcc
|
1321tgactcagtc tgacataggg gtggctgtct gggagcagca
cacccactcc aggatccccc
|
1381agaagcattc gttgtttctt tctgtttttt tttggttttg
ttttttctgt tgcccaggct
|
1441ggagcagtgg tgcgatcatg gctcactgca gtcttgatct
cctgggctca aatggttctc
|
1501ctaactcagt ctcccaagta gctgggacca caggcacgca
ccaccatgcc tggctaattt
|
1561taaaattttt gtattttttg tagaggctgg gtcttactac
gttaCCCagg ctggtctcaa
|
1621actcctgggc tcaagcagtc ctcccgtctt gacccccaaa
gtgctgggat tacaggcatg
|
1681agccactgtg cccaacctca ttgtttcttt tcattttggt
tattgagctc tctctggata
|
1741acatctgcag aatgtttcat gtgtcccgag tatgtgccag
gcCaattact cagcaattct
|
1801gcttcaagaa tcagtctgta ttccattaca ccagtggtac
attttcaaaa tggaaggaat
|
1861ataaaatgta aaagtatttg ctacgcagag gagggagaca
ctactgctgg gactagaatc
|
1921gaagttttct cacacccagt tcaatgcctt ttctacaaca
tccctcagtt gagccttagg
|
1981gtaccaagtg gatggtcatt agtcttgtat ggactttaYa
tccaatgctg attataaggt
|
2041ctagatgatg ctaggtggca gagattcaaa gttggacagg
tcggttactg tacttgataa
|
2101ataaacagcc cagtggcaag acagataaat aaactgacca
tttacaccct gaaaaggtgg
|
2161tcagttgctt agggaactgg gggaggggcg ccaaatggag
gagtagggac atggtagaga
|
2221gggcttttca gcatagtgag tgaatgaatg ctcatttgaa
gaaacaactt gtgtttaaga
|
2281tgtttttctt tcttccagag ctagaatctg gaagaatctc
tgggctttcc tgctttgagg
|
2341gagagatcag gctaggtgca ttgccaattt gctgctgaag
atctgattag gttctgcttt
|
2401gatgtgatca aatgagatgt aatcagtgct ggtactttaa
gtgagtttgc aactatttag
|
2461ttgctctttt tagtagtagt attagtaatg gtaaaactta
gtgcttttag gatgagagta
|
2521gacggcctga agaataatat cttgggctct tctaatcaag
ccatacggct cattggcaag
|
2581tcatcagagg aaacatctat ctatctatac attcatgcaa
taagtattta tttagtgcct
|
2641atgtgccaga cactgtttgt ggggaaaaca agacacatgg
gctattattg cctcatggaa
|
2701ggaactaagc tgtttggatt ttgaaaaatc cctttctctg
ggcctcaatt cctcgacctg
|
2761ttcagaaatg tgcgctcaca atggtcctag acatcttaga
ttcaggttcc attttcagtt
|
2821ctttcctgtc ctgcggccat ctgcaagtta atttggtctc
cctgaacctc agtttcctca
|
2881tctgtaaaat gaagatcata caactcgttt catcaggttg
tactgaggct ggaaaagata
|
2941gtctaactac tgacgcatcg tgtgctcagc ctagggtggc
tgctaccgcg ggtgcctgcg
|
3001gactcctagg acgggcacca gcccgggacc cctgacaagg
tgttgattag ggtgtggcta
|
3061agccccaggc gggagaaagc gttggcattt ataaggccag
ggtctggcgc gstggcctca
|
3121ttccgtcttg aagtagaccc tggagaggtc ttccaggctt
gggctcagca cgcgagcaca
|
3181gggagcgggg gtgccggcgg cggaggcgcg tacggcccga
gcagccccca gcccccagcg
|
3241cgcacacttg ggccaggggc gcgaggagtg cgcggccgcc
gggtgggcgc tggggagcgg
|
3301gccctggggg cggagcctgc agcccaccgc cccccacaca
ccccagccga ggcccggaag
|
3361gggccaggcg cgcttccgtc tccgccgggg atgcacggag
ggcggagctg cggcccgagg
|
3421acgcgacgcg agcccaRttc cggcgaggag gccgcgccag
tgacagcgat ggcggcggag
|
3481tcggcgctcc aagttgtgga gaagctgcag gcgcgcctgg
ccgcgaaccc ggaccctaag
|
3541aaggtaagcg agggggcggc gcgtagcggg atgggcgttg
ggtcggtgag ggccccgtaa
|
3601cggtcgcggc ccgagcgtgg cggggttcgg gggctgggac
cctgagccag gccccgcggg
|
3661gctggggtcg tgaagttcgc ggccattgac cgctgcccgc
gcgttgggac cccgtgcgtc
|
3721gggcgtcggg acgcggggcc ccggccgctc cccctccctc
acgggcccgg gatgggggcg
|
3781cgcccggtgc ggacaccgcg tgcctagcgc ttcctcccag
aggcgctccg tggcgtcccg
|
3841agccagctgt ttcctgcggg agagcgtgcc cggggcggga
gggcgctggc cgccgcctcg
|
3901ttggcctccc ggtgcctgcg ctggtgcccg gctccccgcg
gagcggcgcg gactccccag
|
3961cgggtgcgtg ttcgctggga ggagaagacg ggcgcccgaa
cgctgcggag cctggactcg
|
4021cggtctggtc cgcgcctctc ggagacgcgg ttactactct
ccggctggat atcagagcgt
|
4081ggacctttcg ctttctcagt gaatcccttt caaaacagaa
taaagcctcg cgtcacctaa
|
4141gcatactcct gaaaacttag gttggaattg aaaaagaggc
gggggcccgg ggttggaagt
|
4201cgcagctagg tttccttttg gccattaata ggaaggtaag
agctaccgtt tctcgttgtt
|
4261cgagtgatgg acaaccattt ttaattgtag ttaactagtt
tttgttgttt attgtacaaa
|
4321ctgaaYatta agttaaacgc gttcttgtac cttttcatct
ttctgtcact cacttctctg
|
4381gtctccagga gacagtctgg tggttgtcag gatttttttt
tttctttttt ttttttgagg
|
4441cgagtcttgc tctggtcgcc caggctggag tacagtggcg
cgatctcggc tcactgcaac
|
4501ctccgtctcc cgggttcagg caRttgtctg cctcagcctc
ccgagtagct ggtattgtag
|
4561gcgcccgcca ccacgcctgg ctaatttttg tatttttagt
agagacaggg tttcaccatc
|
4621ttggccaggc tggtcttgaa ctcaRYtgtc aggatttttt
aagtggaagt acaacgatga
|
4681aaaagcactt atgtgtttgg cattctccgt catcattctg
gccggggcgg gcagttctag
|
4741gagttggaac tcagtcctgg tggaaaagga agtcgtggag
ggagggctag ggccgtgggg
|
4801gaactgctct gctgagcctc ttcctcacct gctgcttcct
aggactaacc tgaaaggcta
|
4861aggtaccagg ctgaaagtca gtgctcagaa aaccaatcgt
cattctttgg ggtttttttt
|
4921cttgaagagc cactttctct ttaccttgtt ctagcctgtt
ggaggtaggg tttctgcaat
|
4981tccaaaggcc gtacacagcc tctcaccatc agaccacttt
ttaaggctct tcgttcatac
|
5041ctagctcgaa gattcacttc ctcaggaagc cattttagtt
acaaatctgg gaaaacttaa
|
5101aatgctttca ttgtgccatg ttttctgttg cagcttcagt
accgtaccta gtggtcaggc
|
5161atacttacaa gtttcttttt acagtaaccc cttgtggaca
tctaataaat ggtcattatt
|
5221ttttagtact agtttgtttt cctgaacact gtaagatctg
tgactgacgt ttgatacctt
|
5281aaagcagtgc catataataa ctacccacta tttgttcttt
atttctgtca gataaaaatg
|
5341ttctatgtag tgtctacagt catttttttt ttaactagaa
tttagatttg gaagtagttt
|
5401ttctattagt tgatttgcat gaaatacaaa attaggaaaa
ggcttattcc acctcaacct
|
5461agttgaacta ttaatgattt tttttttttt ttgaggattt
gggctctttc tagatagaaa
|
5521atcaccctga acttctagct ttgcattgtg aagtgagcat
catgaagatg agaaaatgtt
|
5581gggagatcat ttttgcaaag ggcataatag tcggcattca
gatatgagtt aactgcagag
|
5641ggaaaattgc aagctgtcat gttggccttg ttcctctcaa
ccttctggta acctaacaag
|
5701ctcctacagg ttgtatgtga aattgcaaga tgattatata
gccctgttga atttacaacc
|
5761agatcttgct ttcaaaccat tattagccaa gggtttgatt
ccacacctgt gttcatggat
|
5821tttttggtaY tagacattgc tgtaactctg ttttcacttt
ttcatctgtt atcttggctc
|
5881acttaaggga gaaggtatca gcagcctagg accacttggt
ttctgttttt atgtttcata
|
5941gttcatggct gataaaaatt acctgtcctt aggccgagtg
cagtgcctca cacctgtaat
|
6001cccagcactt tgggaggccg aggtgagtag atcacctgag
atcaggagtt cgagaccagc
|
6061ctggccaaca tggtgaaacc ccttctctac taaaagtacg
aaaattagcc aggtgtggtg
|
6121gcaggcgcct gtaatcccag ctgctcggga ggctgaggca
ggagaacact cgaacccggg
|
6181aggcagaggt tgcagcgagc tgagatcgcg ccattgcact
ccagcctggg caacaagagc
|
6241gaaactccgt ctcaaaaaaa aaaaaacaaa aaaaacacac
acacacagtt ggccgggcgc
|
6301agtggctcac gcttgtaatc acagcacttt gggaggccaa
gaggggcgga tcatctgagg
|
6361tcaagagttc gagaccagac tggccaacat gatgaaaccc
catctctact aaaaataaaa
|
6421aaattagttg gtcatggtgg tggtgcctgt aatcccagct
actcgggagg ctgagacagg
|
6481agaatctctt gaacccagga ggcggaggtt gcagtgagcc
gagatggcac cattgcactc
|
6541cagcctggac aacaaKagca aaactccWtY tccaaaaaaa
aaaaaaaaaa aaaaaaggat
|
6601cctcgtcctg tgttacattt tcactgtgaa agctaccaag
aacattttga tggcaggtga
|
6661cattaaaaat attttttgct tttttgggtt gaaggattgt
acaggggaca actgagatgc
|
6721ctcaacatgt accttgcaaa tgtttgatat ttctcagttg
cctgttacca gttcttacaa
|
6781gctctatagt tggtatcttg tttgataaca gcaagtttcg
atccacctga ggatgcccaa
|
6841tgtgcctttg ccttgttatt gctttgttct ttcttgaaat
ttactgaaaa tagaggggtt
|
6901gtgaagtcct tttttctctt gtgttagact aaatgagtct
gaaaatcttg agggttttag
|
6961ttttgtctgc ttttaaatca cccctaataa cccaaagtaa
agcagaaaga caggatttgt
|
7021tcttccagtt agtgctaggc tttgagataa acacacccac
agtgacttcc agcctcatcc
|
7081ttatatgttg gctttgtaga ggtcctggga cacctttgtt
cccttggtga cctcctttac
|
7141tatgtgggtt ctgaactgtc taatgacatc acaggaggag
tttttctgct ttcttgcaag
|
7201tatgctaaga agtatatgtg ctgccgctct attttcattt
cctaaggaca gtgttctgat
|
7261gttggatgct tctcctggct ttacttaact gtagtagaca
catttgactt tccagcttgt
|
7321taagcaagtt acctaacctg attgggttca gttgcaatat
ctgtcaaatg gggagaataa
|
7381catccacttt atagagttgg ttagtgggaa tgaaatgagg
taacgtgtaa gagcttagtg
|
7441tagtagctga cacacaatag atggtatgtg aatattccca
acctacccct tccaaggaat
|
7501ggcattatga gagaaccact tgtttttgac cttttcagtg
atttaaaatt ttcctttaag
|
7561tgaaggaatt ggcattagtc tttgcaccca tagcttgggt
ggcaagaaac acaaaatttt
|
7621tcctgagttg gatgatggtg gtgataggat ttgaagtggg
ggataatttt cactcatcta
|
7681tgaaggtgag actccctaga tatgccactt ggcctcttac
ttgatctcaa gattatcact
|
7741tgtgatccaa ttgctctgtc tggtgaccat gttaagtaat
gattgaagta gaatgaccag
|
7801aaaaacagac ttgttactcc acctaatagc aatatggcat
accaattata gtctgggcca
|
7861cacatggtaa aagcagatct tgttatataa tatttaaatg
caaaggtaac cacagttatc
|
7921tattttaaac tacttgtatt ttgaagcact ccttgtatgg
taagtatgtt tagatacacg
|
7981tagacatttc ctagagaaag gtttggccag tcataacttt
tgttagagca agtaggaatt
|
8041ggctgaggaa tatctggttg aagatcaagg gcagaacgct
gaaagctgtc agtcgatgaa
|
8101tgaaatgata agtatttagt gagctttcat agtgttctag
acactatgac taaggactgc
|
8161acatggtttg tctctgaatc ctcatagttt gtgaagtaga
gacaggacca agttcctatt
|
8221ttgcagatga agtaactgaa gtttggggag gtttttgact
tattcaagat cactcatcga
|
8281gtgacaaagc cagattgtca agcctgtctc tgactccaga
actccatctt aacagctctg
|
8341ctgtactgat tttgacctag ttttaggaac tataggaagg
aaatgtgatc aaacccagat
|
8401cacttttcta atctacccag gcattttgtg tccaccgtta
acatccaagc tctgattctg
|
8461gcaacttgaa attactcttg gctttacact tatgtagaag
aaaacaattc tgttaaacac
|
8521tgtggccctt ctggaaacat gatggtcttt tcctgtagag
gccttttctt ccttttactt
|
8581cctctgtgcc aggtccatgg gtaattcccc taaaattggt
acctttctca taaattctat
|
8641caaaactagg gcaaaaatga tagttgttga tggcttttat
cagagttggt aagttttgat
|
8701tctcttctct acatcttatt tccccttggt gtagcacagt
ggttgaaagc agggaatcta
|
8761aagccacaga cctgagtgaa tcttgcccca cttgcatctt
gggacaagaa acataacttt
|
8821tatgagccta ttttcatact tgtaaaatag ggatattact
tactactgta aataggcata
|
8881atacttatac tcattactgt aaatggttag cactaagcac
ttaataatca gatattcttg
|
8941ttaaagtgaa tttgactatt gaaattaatg ttttcttctc
tgcagctatt gaaatatttg
|
9001aagaaactct ccaccctgcc tattacagta gacattcttg
cggtaagaac tgtgtgactt
|
9061taaatattat ataatgatat cccattccct tctcactgga
gagtgtgtag aataaggtta
|
9121caagtatggg ctttggaagt gaaagaaacc agacacaaaa
ggccatatat tgtctgattc
|
9181catttatatg aaatgtccag aataggcaaa tccatagaca
gaaagtagat tagtggttgc
|
9241caggggctag gagaattggg aggaacagga tttcttttta
gggtaatgta aatgttctgg
|
9301aattagatgg ttataatggt tatataatat tgtgaatgtt
ctggaaacca Ytgaattatg
|
9361tactttagtt aaagtggtga atattgttaa atgactttat
ttcaaaatta gaattaaaag
|
9421aacattgact ttggcatcaa ttagtcccag attcaaatct
gagttctatg actttaggct
|
9481gttcctatgt aaaatgggtc tgattcctgc ttcacagggt
tattgtaaag actgattcag
|
9541aactgtatgc aaagctctta tcttagtgcc taacacctgc
cctaatcact cttgttatta
|
9601aagttctgaa cttggtacgc tttgctactg tgtgtcatta
gagatttggg gcatagacac
|
9661aaagtaattt agtgttaaga tttgcagggt atgttgtagg
aaggaagtat tgcttgttga
|
9721gtttctcaaa gtagaaagcc ttatttcttt agaaaaacgt
tagcctagtt ccagacccct
|
9781ctaacaatta ctttgtcaaa ttttaggaga ctggggttgg
gaaaacagta aatagcttgc
|
9841gaaaacacga gcatgttgga agctttgcca gggacctagt
ggcccagtgg aagaagctgg
|
9901ttcctgtgga acggtaagaa catttctctt taggtttgtt
caatttcatg gttaaattta
|
9961cagatagaaa aggttttctt tattatttct cttttgcctt
ctgaaattgt tttgcctcaa
|
10021ttataaaaaa taatccatga tcattgtaga atattagaaa
atattaaaaa tagaaatcaa
|
10081aatttcctat ttctatcacg caaagacaaa cgttatgaac
attttggtac gtttcttttt
|
10141tttttttttt ttttttttga gacagagtct cgctctgttg
cccaggctgg agtgcagtgg
|
10201cgtgatctcg gctcactgca agctccgcct cccaggttca
cgccattctc ctgcctcagc
|
10261ctcctgagta gctgggacca caggcacccg ccaccacgcc
cggctaattt tttgtatttt
|
10321tagtagagac agggtttcgc cgtattagcc aggataggat
ggttttgatc tcctgacctc
|
10381gtgatctgcc cgcctcggcc tcccaaagtg ctgggattac
aggcgtgagc caccgcggct
|
10441ggcctggtat gtttctttct aactgctcct taaatggcat
ttttttaagt tgtgaactag
|
10501ataaatagtg agcagccccc attttatata acaaattaaa
catgtcccca tgttttaata
|
10561aatctccaca ttttcatgta tatgagatat ttgatctttg
catcttgtgg ttaaactcac
|
10621catttctcat ttgggttttc ccagttttaa gatttgagta
tctttaagca taacctactt
|
10681atcttcttct taagaccttg ttgtttctaa ctctgcatct
tcacttcttt ggtgagttca
|
10741gattctgtga ctttgtccct caagaagcaa gatttagacc
tactttgtct gctttttctt
|
10801ttattttaga aatgctgagc ctgatgaaca ggactttgag
aagagcaatt cccgaaagcg
|
10861ccctcgggat gccYtgcaga aggaggagga gatggagggg
gactaccaag aaacctggaa
|
10921agccaYgggg agccgatcct atagccctga ccacaggcag
aagaaacata ggaaactctc
|
10981ggagctcgag agacctcaca aagtgtctca cggtcatgag
aggagagatg agagaaagag
|
11041gtgtcacaga atgtcaccaa cttactcttc agaccctgag
tcttctgatt atggccatgt
|
11101tcaatcccct ccatcttgta ccagtcctca tcagatgtac
gtcgaccact acagatccct
|
11161ggaggaggac caggagccca ttgtttcaca ccagaagcct
gggaaaggcc acagcaatgc
|
11221ctttcaggac agactcgggg ccagccaaga acgacacctg
ggtgaacccc atgggaaagg
|
11281ggttgtgagt caaaacaagg agcacaaatc ttcccacaag
gacaaacgcc ccgtggatgc
|
11341caagagtgat gagaaggcct ctgtggtgag cagagagaaa
tcacacaagg ccctctccaa
|
11401agaggagaac cgaaggccac cctcagggga caatgcaagg
gagaaaccgc cctctagtgg
|
11461cRtaaagaaa gagaaggaca gagagggcag cagcctgaag
aagaagtgtt tgcctccctc
|
11521agaggccgct tcagacaacc acctgaaaaa gccaaagcac
agagacccag agaaagccaa
|
11581attggacaaa agcaagcaag gtctggacag ctttgacaca
ggaaaaggag caggagacct
|
11641gttgcccaag gtaaaagaga agggttctaa caacctaaag
actccagaag ggaaagtcaa
|
11701aactaatttg gatagaaagt cactgggctc cctccctaaa
gttgaggaga cagatatgga
|
11761ggatgaattc gagcagccaa ccatgtcttt tgaatcctac
ctcagctatg accagccccg
|
11821gaagaaaaag aaaaagattg tgaaaacttc agccacggca
cttggagata aaggacttaa
|
11881aaaaaatgac tctaaaagca ctggtaaaaa cttggactca
gttcagaaat tacccaaggt
|
11941gaacaaaacc aagtcagaga agccggctgg agctgattta
gccaagctga gaaaggtaac
|
12001cccttcagcc ccttggtggc ttcccaccca gagcacctgg
ccctgcagag ctcagaggat
|
12061tgccctgcca ctgttttcct tagcttgctt ttggggggca
tgttgaattt cagtgtgcag
|
12121taatttcctc tgggcttcac tggttgtcag ggtatatggt
accgcaaata agaattttct
|
12181gcattattct cttgtgatgg gctcatctgt atttatttcc
tgactgaggt ggtgtcagac
|
12241atgactgtgg ccccctccaa cctggatctt cctgtgcaag
atgtccagtt aatgctcccg
|
12301ggaatagact gtaggaaaga gagctgtgct tctactcact
gactctccac ccatgggtct
|
12361gtcccctgca ggtgcctgat gtgttgccag tgttgccaga
cctcccgtta cccgYgatac
|
12421aggccaatta ccgtccactg ccttccctcg agctgatatc
ctccttccag ccaaagcgaa
|
12481aaggtaattt tctatatctt ctttttctta atgggaaaaa
gatttaaaaa ttcattcaag
|
12541gcagggtaca gtggctcaca cctataattc cagcactttg
ggaggccgag gtaagaggat
|
12601tgcttgcggc caagggttct aaaccaacca ggcgtggtgg
ctcactcctg taatcccagc
|
12661actttggRag gccgaggcgg gcagatcacc ttaggtaaga
agttcgagat tagcctggcc
|
12721aacatggtga aaccctgtct ctactaaaaa tacaaaaatt
agccaggcat ggtggtgcgt
|
12781gcctgtaatc ccagctactc cggaggctga ggcaggagaa
ttgcttgaac ctgggaggtg
|
12841gaggttgcag tgggccgaga ttacgccatt gcactcaagc
ctgggtgaca agagggaaac
|
12901tctatttcaa aaaaaaggag ttctaaacca ccctggtcaa
cacagcaaga tgctgtctct
|
12961acaagagaaa aaaagtagcc aggcatggtg gcacatccca
ggtactcggt aggctgaggt
|
13021gggagtatca cttgagccca ggagttcaag gctgcagtga
gctctgattg catcactgca
|
13081ctctagcttg ggtgacagag caagactgtt tcaaaaacaa
acaaaaaaac tatcaccata
|
13141acatcagatt tttgatgcat ttcctaagtg catagactct
gaagtttgat ggcttgggtt
|
13201tgaatcccaa ctctggtttc tgcaagttat atgaccttga
gaaatatctt aatttctttg
|
13261gaccttagtt gtatatattg tgtaaatggg agttataatg
gtatctgccc catagggctc
|
13321agtttaatga attcagaagt gatgcctttt tgctctgggt
ttatcacata gtaattgttc
|
13381agtaaattgc tgctgctgtt attagcagcc ctttatccta
tgtgttacat aggatttttg
|
13441tctgaaagaa aaaaatgtct aattttcata gcaaaagaag
tagaagccac ataagggtct
|
13501atcagcagga gactaacaga taaatcatgg ttcatctaca
cagtggcatc ctatgccaca
|
13561gtaaaaaaaa aatgtggaaa gtctatgcac tgacatggaa
tgatctctca gatgtggcaa
|
13621atgaaaaaaa gcaatgtatg tagtgagtat gttattaatt
gattcattgg cttaaaagga
|
13681ataagataca tttgcttttt tttgttgttg ctgttgagag
tcttgctgtg ttactcaggc
|
13741tggagtgcag tagctccatc ttggctcact gcagcctcca
cctcctaggt tcaagcaatt
|
13801cctctgcctc agcctcctga gtagctggga ctacaggtgc
atgttgggca ggctgatctc
|
13861gaactcttga cctcagatga ttcatStgcc ttggcctcct
aaagtgctgg gattacagga
|
13921gcttattttt aaattctctg gaaggatcta caaaaatctg
tagcgtggat tgccattggg
|
13981aaagggaagt aggaggctga agggggtaga aggagagttt
tcactggatc acttagggcc
|
14041ttttgtgttt ttcttgccct atagcgttct cttcacccca
ggaagaagaa gaagctggat
|
14101ttactgggcg cagaatgaat tccaagatgc aggtgtattc
tggttccaag tgtgcctatc
|
14161tccctaaaat gatgaccttg caccagcaat gcatccgagt
acttaaaaac aacatcgatt
|
14221gtaagtcaca cgcttctctc tagctctcaa gcacattgta
gcacttggac cttatcactg
|
14281ggtggcttgg ctgctactca gtgtcttcac ctttggtttc
tctgcagcaa tctttgaagt
|
14341gggaggagtc ccatactctg ttcttgaacc cgttttggag
aggtgtacac ctgatcagct
|
14401gtatcgcata gaggaataca atcatgtgag tattctgttt
gggtgggaag agggcagttt
|
14461tctggcttgt acctccagaa atagctttgt ccctgtgact
ccgctgtggc tgaagggcag
|
14521atcagtggtc agagcattgt tctggatata tttggtttgc
cactgggcct ttaaacaagc
|
14581atgttattag cacttgctcc tggcacctta agtgggcctc
ttgggctagg atcagggtgg
|
14641gattcaaagg gagaagaaaa acacttaaca tctcccttga
gcttgcctag tcatgaaggt
|
14701aaagggagaa ttctggcagc agagtagctg ggacccaggg
cggggaaagc actttgtgtt
|
14761gacactctga catctggtga ttggctggat gtctcttaag
aaacatcaag atttatccag
|
14821aatcctcctt aggatgtagg gtatacacat ttgattgcat
cagctgtctc tctttaattc
|
14881tgaaagttct atgacctaac accttttttt ttttttttgg
agatagggtc tacctctgtt
|
14941gcttcgactg cagtacagag gcctaatcat ggcttactgc
atccttgaac tcctgggctt
|
15001aagtRatcct cccaagtagc tgggactaca ggcacatacc
accacagctg gctaatattt
|
15061ttatttttta gagagatgga ctctcagact cttggcctcc
tgaagtgctg ggattacagg
|
15121catgagccaa cgcgcctggc caataactta acatccttct
taggttgccc ctttgccatc
|
15181acagttcagc gtagtgttgg gaagtacctg atttgacttg
atcgcagttc taccctttgc
|
15241tgattttcta aaggaaaaga ctgatgttac acagattttt
gtgatattct gtcacagcca
|
15301ccaaaagcaa ctagcatagt gcctcacact tcgcattttt
aaaatttagg gagttatttt
|
15361tttcctagaa ttgtggtatt ttaacaWact actaagatga
agaccaaaaa atttttggga
|
15421aactggtcac tcctaggtaa ttaaataatc agaaaaagat
atgaggctgg gcatggtgac
|
15481acacgcctgt aatcccagca ctctgggagg ccaaggtggg
cggattatct gaggtcagga
|
15541gttcgagacc agcctggaca acatggcaaa accccatctc
tactgaaaat ataaaatagc
|
15601tgggcgtggt ggtaagcacc tgtagtcctg gctacttgRg
aggctgaggc gtgagaatcg
|
15661cttgaaccca ggaggcaagg gttgcagtga accaaaattg
caccactgca ctgcagtcta
|
15721cacgacagag caagactctg tctcaaaaaa aaaaaaaaaa
Watggaaaag tgcttgtaca
|
15781caaatgatgt cctggttctg gtttcaggta ttaattgaag
aaacagatca attatggaaa
|
15841gttcattgtc accgagactt taaggaagaa agacccgaag
agtatgagtc gtggcgagag
|
15901atgtacctgc ggcttcagga cgcccgagag cagcggctac
gagtactaac aaagaatatc
|
15961cagttcgcac atgccaataa gcccaaaggt aacagagacg
ggagagctgg gggagaactg
|
16021gcaggatgag tgttctggtc aatagcaggg tgttggtggg
cttggctggt gtaggactgc
|
16081ttgcccctac atcaggtagc agggtgggta tttcttctgc
caccgcccat tctaccctac
|
16141aagtggggtt tcagggcact caaaaagccc gtggattatt
taaataacag tagcatctct
|
16201gctcaagaag gcagatgttc atctccataa ttccacaggc
cgacaagcaa agatggcctt
|
16261tgtcaactct gtggccaagc cacctcgtga cgtccggagg
aggcaggaaa agtttggaac
|
16321gggaggagca gctgtccctg agaaaatcaa gtaagatctg
tgttcttacc tggcttttgt
|
16381gtgctatcaa cccttagagg tagccatagc ggcaggaagc
aaattgcttt tggtgaaagt
|
16441gaggcagtgc agactgtggg ctctggaggc agacctcatc
agctcagcac ttccctcacc
|
16501tccctcagcc tccgcttctt ggactgcagt gcaaggtgat
aattacccct gccctagggt
|
16561agtcaagatt aaatggagag caaagcctgg cttatgggaa
acattccctt atgctttccc
|
16621ttttcccatc taaacaaaaa acacatttct gcaatgattg
ttattttgtc taagccacat
|
16681tagccttttc aaaatacaga tttataccaa aacagtgaaa
agttagttga gattatcatt
|
16741ttttctgaaa ggataatgga gacatctctg agccaccacc
agaatccagg gtgatagggt
|
16801ccattggtca aagccacaaa cagggtgagt catcctcaca
caggccagct tcaggctgtt
|
16861catgctcagg gcagatttct tgtgctcatg cctaaccagt
gttgtcctgt gttgcaggat
|
16921caagccagcc ccgtacccca tgggaagcag ccatgcttcc
gccagtagYa tcagctttaa
|
16981ccccagccct gaggagccgg cctatgatgg cccaagcacc
agcagtgccc acttggcacc
|
17041agtggtcagc agcactgttt cctatgatcc taggaaaccc
actgtgaaga gtaagtaact
|
17101tggagttcct gctcaaatat tatYtcagca ctagttttta
actctcaatg tcattattca
|
17161ctgtattaca ttttgtggac tgcatgttgc atgtacatga
tgccttgcac atagctggtc
|
17221tgaatgtcag tccctccttc cccctgcttt gtccatagtg
cattatatct cttaaatagt
|
17281tatagtgagt ctgggtgcag tggctcatgc ctgtaatccc
agcactttgg caggctgagg
|
17341caggaggatc ccttgaatcc aggagttcRa gaccagcctg
gacaacataa tgagaccctc
|
17401tacaaaaaat taaaaaatag ggcatagtgg tacacacctg
tagtcccacc tactcaggag
|
17461actgaggtgg gaggattttt tgagatggag tctcgctctg
tcacccaggc tggagtgcag
|
17521tgScacaatc tcagctcact gcaagctctg ccttccaggt
tcatgccatt ctcctgcctc
|
17581agcctcccaa gtagctagaa ctacaggtgc ccaccaccat
gcccacctaa ttttttctat
|
17641tttttagtag agacggggtt tcaccatgtt agccaggatg
gtctcgatct cctgacctcg
|
17701cgatctgccc gccttggcct cccaagtgct gggattacag
gcgtgagcca ctgtgcccgg
|
17761ccgaccctgt ctctggaaaa aaaaaaaaaa aaaaagtgaa
agtagaaaat agtatctggc
|
17821caggcatggt ccctgtctct attaaaaata gaaaaattag
cccaccatgg tggcatgtgc
|
17881ctataatctc aggtactcgg gtggctgaga caggagaatt
gcttgaacct ggcaggcaga
|
17941ggttgcagtg agctgggatt gtgccactgc cctccagcct
ggatgacaga gtgagacact
|
18001gtctctaaat aaataaataa atatcattgt gaatgaccat
tttggcactc ttcttttttc
|
18061acctaaatat aaactgactt ctctaggcaa taccacagtg
ttcataatta ctaatattaa
|
18121cagctaaatg acaggccctc ttactgtttt tttatagWct
tataactcta gcttccaaat
|
18181atttattctt tatatctaat tgggtcttcc aatttatttW
tttWtttttt tttttttttt
|
18241tttttttttt tttttggaga cagagtctca ctctgtcgcc
tgggctggag tacagtggcg
|
18301tgatctcggc tcactgcaac ctccacctcc caggttcaag
cgattctcct gcctcagcct
|
18361cccaagtagc tgggattaca ggtgcccgcc actaagccca
gctaattttt tgtattttta
|
18421gtagacacgg ggtttcacca tgttggccag gctggtctcg
aacccctgac cttgtgattc
|
18481gcccgcctca gcctcccaaa gtcctgggat taccagcgtg
aaccaccatg cctggccRgg
|
18541tcttccaaat atttattctt tatatctagt tgcgtctatt
ttgtattttg ttaactttat
|
18601taccatagac tatccccagt atcctaaggg gatgtcctaa
cttaagtctt attctgtatt
|
18661aattgcaggg cccatgggag ggtgggagtc ctggcttgag
ctacagctat gctcagatga
|
18721accattcagg aggcaggctg gccttcctta ggcagtactt
gcatagccac cttagacctg
|
18781tttctacact ggacagattg ggggtagacS tgctgtttac
tggtttggct atttgtgagg
|
18841caaagttaag ttatgactga gtatggcctt tagagtctgg
caagggccgg ggcacagtgg
|
18901ttcacacaca cctgtaatcc cagcactttg ggaggctggg
gtaggagggt gcttgagccc
|
18961aggagatcga gaccagcctg agcaacatag tgagaccctg
actctacaga aaataaaaaa
|
19021aaattagcca ggcatggtgg cacactcctg tagtctcagc
tactctggag tctaggaggt
|
19081agaggctaca gtgtgctgtg attgtgccaa tgcaccctag
ccagggtgac agagtgagac
|
19141tctttcctta caaaaataaa aacaagaaag tctgacagag
attgaattgt aattctgtac
|
19201cttactgtac aaccatgggc aagttggcca ggctctctga
gccttggtgc aggtggttag
|
19261agagagtggt ggtcatgccc ctggcaggtc ctccgaaagt
gtctgctctg tgctgttgct
|
19321tttattgcat tgtgaacaga ggagatagtt actacttgta
tctctgcctg gtggtgcaca
|
19381gccaagaata gcagagctgg ctttgactgt aaactactgg
gggtgtgtct aagccgccac
|
19441agatctgaga cagctgcctt gtttctcttt tcacagaaat
tgccccaatg atggccaaga
|
19501caattaaagc tttcaagaac agattctccc gacgataaac
tgaggacttg ccttggaaat
|
19561ggaatctggg gaggcaggaa tacaaggaca gtgggggttg
gggaatggaa ttctacagga
|
19621gactggagtc ttgctttgtg gatccttttg gtctccgagt
cctgcagtct gcaggtgctg
|
19681cccctgggaa cctgcgtgcc acagccccgc ctccctgcct
ggagcacact ttagaattct
|
19741gaagatgtga agcctctgtc tcactgagga ttttaaaggt
caattatact tttgttgttc
|
19801attagcatct ttgtaaacta taagacgtag ttttaattaa
taaatattgc ccccagattg
|
19861tatttatatt atcccccagg tttgtttttg ttttttgtcc
tctaccacac atttagcctt
|
19921ttatcttcca ggtccttatt aaaatcagat gaaagcctag
tgaaagccag tctcctgccc
|
19981cagctcagct ctgtgtggac tctggtccag acagaggact
gggcatctcc agagcctgca
|
20041cagtacctgc tgcacgtagg gcaaggaatg agcactagac
cgcctgtccc caagggagcc
|
20101tcagtggggc gacagggtgc tcggcggact ccacctcagg
ccctccccac tgttgctgtg
|
20161cattcctgtg caggtgcatc tctttcttac taactggtat
ttattaaggg aggtgctctg
|
20221taggtctgga gcctttccct catccttttt gcgagtcccc
acctttttgt tttttttttt
|
20281tNctttgagg ctcactagag gacgcagaac cttgggagat
tgatttgcac agaactcccc
|
20341acctcccact tttacaattt ccagtttctg attgaaaatt
ttagggtttc tccccactgc
|
20401ccttccctat ctttccttcc cctcaacacc atgaaggaaa
aacacacacg gcagggcttt
|
20461ttgtagccct gaaggcaact ttagacattt aaaaKccagc
actttaatct cttgttctct
|
20521gtgaatcact atgagaagtg aatggtttta aaggctgtaa
tgctatgttg gaaattggtt
|
20581tgttttgcct tttattgaaa aggtaagatc atgtgattgg
aagaacacaa ctRttggctt
|
20641gggaagagga ctttgctgYt gaagtgtttt ctaccttctg
agtgtgttta aggcaggatt
|
20701tggagggaag gaccagctta gggagagtgt ctgagccaca
gcgtcaggat gggggaaacc
|
20761acatgggatc catcaagttc cagttgaaca ggagcaagat
cagaacttag gagggcagtg
|
20821tcagctccct tgttggctgt caaggaacac cgatctagta
gaaacccact tggttgtgac
|
20881ccaggtagag gtagatgcca tacatttgag atatgcgtcc
ttaaggaacc tgacaagcag
|
20941actgaaggga tggtaagtgt gacagcctga taagttttct
caaagcccag gatacagagc
|
21001cagtgttttc tgtaactgga gacctcagtt aggccaactt
cgaattccag agcaacgtag
|
21061gaagtctatt cagcagaaac tcgacattgt tcagtgtgta
ttgctgtgca gggtgcctat
|
21121tgtgacagga cacaaatgtt actatgtttt aatttgctat
atttttgaat gggtaaagca
|
21181ttactttact tctcttggtt acttgtacca ccattccacc
cctatcccta gcctgcccca
|
21241caaatctaat attaggaagc ctcttaactg aaaccaaatg
aacatttggg tcaggtgcca
|
21301gatgtctgct gcctagaata gctttttcta ggtgtctacc
accttgaatt tatctcttaa
|
21361ctgtgtgttc aagtctttgt cattgaaact agtttttcat
atcttagatt cagttgtgta
|
21421tgatttaatg tcccttatta ggagtcttta ggcagggagg
gaagaaaaaa cagatttgtt
|
21481catagcaatg tcagtatcca ttttggcaca taaagatttt
tgatgagccc tgtttgcata
|
21541gagccagatg ttttcccctc ccccaagagt atctacatca
gggatgtgac ttggtgcgaa
|
21601gaRtcagggg aaagaggaaa aacccaattt ctaaatgacc
tccttgccca gcttactaaa
|
21661atggctgcag agcagacaca ggatgaattt gaacctgaca
caggatgaat ttgaaccttt
|
21721ggtctcattt atggaaaaac ttgtgcaatt ttttttctgt
gctacactac atacaaatca
|
21781ccaaattaca aattaccctt ttgtgatcct tggtgtactg
agcagtttct ttggggcttt
|
21841ttctttctgg gaagcgggag ggaaaggagc aaggtgtcat
cctgctcttc atttgtattt
|
21901tggtcccaaa atgtaaatac aattttctat gttacttttt
tgtggtaact accgagatga
|
21961atattttaat tagataagtt atatgaaaag gaaaattcca
tgtctaaata aaaaacaaac
|
22021tccatatact gtgtcttcct tacttatagc atcagtggaa
agaagttaga aaatgcctga
|
22081ttcttggact gtttaaggca gagttttttt ttttgttttt
ttttttgaga tggaggaggc
|
22141aatctcagct caccgcaccc tcctaaggca gagatcttaa
tcagcatcct tgggctgggc
|
22201cttaaacgat gccgaattta gtagtaagag gaatttcaga
cggaaagaat tctgtgagca
|
22261aagggcggga actcagcatt tgtggggaac aggcactgtc
ccttattata cttggaaccc
|
22321tggtaacccc atcttaaaat tagaaactgg ttcaaagggg
tgaaatgggg ccgggcatgg
|
22381tggttcatat ctgtaatccc aacactgaag ggcggaggca
ggattgcttg agcccaagag
|
22441ttcaagacca gcctgagcaa catattgaga ccctgtctct
agaaaaagat taaaaattag
|
22501ccaggtgtga tggtgcacct atagtcccag ctatgtgaaa
ggctgaggtg ggaggatcac
|
22561ttgagcttgg gaggtcgagg ctacagtgag ctgtgattat
gctactgcac tccagtctag
|
22621gtgacagagc aagaccagcc tgggcaacat ggcaaaaccc
catctctttt tttgtctcaa
|
22681aaaaaaaaca ggggtagggg gttaggaggg actgtggctc
atgcctgtaa tcccaacact
|
22741ttgggaggcc aaggagggtg gattgctgga gttcaagagt
ttgagaccag ccttggcaac
|
22801atggcaaaac tctatctcta caaaagatac aaaactagct
gggtgtggtg gcacacacct
|
22861ttggtcccag ccactcggga ggtagaggtg ggaggatggc
ttgagcccag gaggttgagg
|
22921ctgcaataag ccatgattgc cactgcagtc cagcatgggc
gacagagcaa gaccctgtct
|
22981ccaaaaaaat aaaaaacaaa cggggagggg ggggaaagga
gtgaaattaa catggccaag
|
23041ttgcgtagct aataaagtgg caaaaggaag gatttgacac
cgtgattctc taactgcaag
|
23101gtttgtgcca ctctgccttt cagtttccac gggctgtgag
ggaccagtag gtctcagctt
|
23161acacgggcgt tctaatgagt acagaaggaa catgaatgca
ggaaagtcgt gccagcaaag
|
23221acttaatgag aacctgctgt ggtggctctg gctgacctgc
aggagcttta gcacttgcta
|
23281atggagccat ggatttggct tcaaccctgc atacagcaag
tggattggac cttccatcaa
|
23341acatacaaat ctgtccttta tcgattaatt aaacatttgc
tgagccagga cctgtattag
|
23401accttaggat atggagtaat agactctgac acttaacagt
tagggaggag taactgactt
|
23461tattgattat gcacctacta ggtgccacca ttccttcttc
tgtacactgc ctctgttatc
|
23521acaatgatcc tgtgaggtaa acagtcatgg ccccatttta
aaaatgacaa cttaatcctg
|
23581gtaaatccag gggattaaaa aataaaaatg agaacttaag
tcaccatagt gtctgtagaa
|
23641ataaatttta aaaaattgtt ttaatgaaaa tgagaaaaac
cgaagcacag agagatgaag
|
23701aacttgccta agttcacaga atcagtgagc agtggtgcta
tgtattggcc tgactccaaa
|
23761acacatgctc tcagtcacat ttaccatctc atacactgac
atgcataccc aatttggcct
|
23821ctgaagcaaa gctgacctcc aaaacaaaag atgcctgagc
caaggccaga gtcgtttctg
|
23881tttttttttt ttaaattctt tttttgtgat ggagtctcgc
tctgttgccc aggctggtgt
|
23941gcagttgcac gatctcggct cactgcagcc tcagcctcgc
gagtagctgg gattacagac
|
24001atgtgccacc acgcccagct aatttttata tttttagtag
agacagggtt tcaccacgtt
|
24061ggccaggctg gtctScaact cccaacctca agccatctgc
ccgctttggc ctcccaaagt
|
24121gctgggatta caggtgtgag ccaccgtgcc cagcctaaaa
attctttatc ctcaagttca
|
24181acagtcattt Ytaagaatga tatcttttgt ctgcttcatg
taactgatgc ccagcagaat
|
24241cctacctggc ttatcaactt gacagatgcc cccatcacag
ggtttctcat ccactttcat
|
24301ctcttcctgg ttatttgcta aatggtgaaa cagtttgtct
tcagaggccc ctgaacttct
|
24361ttctctcact ctttttgaga cagtctcact ctgtcaccca
ggctggagtg cagcggtggg
|
24421atcttggctc actgcagcgt caacctccca ggctcaagta
ttcctcccac ctcagcctcc
|
24481caagtagctg tgactacaga tgtgcaccac cactcccaga
taattttttg gtattttttt
|
24541gggagatgga gttttgccgt gttgcccagg ctggtcttga
actcttgagc ttaatcactc
|
24601taccttggcc tccaaagtgc agggattaca ggcatgaggc
acctcgcccg gccccctgaa
|
24661cttctctatg atgtctattg tctcaactct tttcaaagac
taaggaaagt tccagccatc
|
24721aaaattttat atcactgtat ctgtttctca agcacagagt
cttgggttgg ggcctcagaa
|
24781tatgcattta aaaagatgca actcaagtgt tatggactaa
atgtttgtgt ccccccaaaa
|
24841tgcctatgct gaaatcctaa gacccagtgt gacagtatta
gataggcctt tggaggtaat
|
24901taggtcacgt gggtagaggc ttcatgaata ggattctccc
tcataagaga aatgagagtt
|
24961gctcttgctc cttgttctcc accatgtgag gaaatgagag
gacggcagtY tgcaaaccaa
|
25021gaagagggcc ctcaccagac acagaattgg ccagcgcctt
gatcttggac ttccagcctc
|
25081tggaactgtg agaagtaaat gtttgttgcc taagccagtc
agtYtatggt aagttgttac
|
25141agtaScctga aatgactgag acactaagcg attttttttt
tttttttttt tttttttttt
|
25201tttttttttt tttttttgag gKgaagtctc actctgtcac
ccaggctgga atgcagtagc
|
25261ttgatcactc tcggctcact gcaacctYtg cctcccgggt
tcatgtgatt ctcctgcttc
|
25321agcctcccta gtagctggga ctacaggcgt gcaccaccaa
cttttgtatt tttagtagag
|
25381atgggtttca ccatgttggc taggctggtc ttgaactcct
gacctcaggt gagatcaggt
|
25441gagatccacc tgcctcgacc tcccaaagtg ctgggattac
aggcatgagc cattgtgcct
|
25501ggcctgacac taagcatttt ttttttgggg ggatggagtc
ttgctctgtt ccccagactg
|
25561gagtgcagtg gcgtgatctc agctcactgc aacctccgcc
tcccaggctc aagcgattct
|
25621cctgcctcag tctcccaagt agctgggatt ataggcatgc
atcactacaa cccggctaat
|
25681ttttgtattt ttagtagaga cggggtttca ccatgttggc
caggctagtc ttgaactcct
|
25741gacctcaaat gatccacccg cctctgcctc ccaaagtgct
gggattacag tcatgagcca
|
25801ccacgcccgg ccgacactaa gcaattctta aaatgtacac
tgaagtttga gaactgctcc
|
25861agagaatttg ccacagtgga atagctcttc acagcaggtc
cctaggtcag gactaggaag
|
25921cttgttgatt tagtagtaag caaatacttg cattgcttcc
cactctgtgt cactgactaa
|
25981gtcagacatg gcaggctggg gacagtggct cacagctgta
atcccagcac tttggggggc
|
26041caaggtgaga gattacttga gtccaggagg ttgaaactaR
cctgggcaac atagtgagat
|
26101cttgtctcta aaaaaataaa atattaggcc aggcgcggtg
gctcatgcct gtaatcccag
|
26161cactttggga ggctgaggcg ggcagatcac ctgaggtcag
gagatcaaga ccagcctgac
|
26221caacatggag aaaccccatc tctactaaaa atacaaaatt
agccgggtgt ggtggcacat
|
26281gcctataatc ccagctactc gggaggctga agcaggagaa
taccttgaac ctgggaggtg
|
26341gaggttgaag tgagccaaga tcatgccatt caaaataaaa
taaaaataaa acaaaataaa
|
26401ataaaatatt agttgggcat ggtggcatga acctgtagtt
ctagctactc aggaggctga
|
26461ggtgggagga ttgcttgaac tcggggaggt tgaggctgca
gtgagccaag atcatcccac
|
26521tgcgcaccag cccgggtgaa agagcaagac cctgtYtcaa
aaaagaaaaa agaaaaaaaa
|
26581aaaaaaggcc aggcatggtg gctcatgcct gtaatcccag
cactttggga ggtcaaggca
|
26641gatgaatcac ctgaggccag gagttcgaga ccagcctgac
ccacatggag aaactccgtc
|
26701tttactaaaa atacaaaatt agctgggcgt ggtggtgcat
gcctgtaatc ccagctactt
|
26761gggaggctga ggcaggagaa tcgcttgaac ccaggaggtg
gaggttgcgg tgagccgaaa
|
26821ttgtgccact gcactccagt ctggacaaga gcaaaactcc
gtctcaaaaa aaaaaaaaaa
|
26881aaaaaaagag acatggccct tgccctcatg aagctttcat
ctagtaggga gacagttatc
|
26941aaataactgc acaaataatt cttttttttt tttttttttt
tgagacaaag tcttgctcta
|
27001ttggcaggct ggagtgcagt ggcgcgatct tggctcactg
caacctccgc ttcccggatt
|
27061caagcaattc tcctgcctca ggctcccgag aagctgggac
tacgagtgtg cgccaccatg
|
27121cccagctaat ttctgtattt ttggtagaca cggggtttta
ccatgttggc caggatggtc
|
27181tcgatctctt gacctcgtga tctgcccgcc tcggcctccc
aaagtgctgg gattacaggc
|
27241gtgagccacc gcgcctggct tttttttttt tttttttttt
tttttttgag acggagtctc
|
27301actctgtcac cagggctgga gtgcagtggc gcgatctccg
ctcactgcaa gctccacctc
|
27361ccggttcacg ccattctcct gcctcagcct cccgagtagt
tgggactaca ggctcYcgcc
|
27421accacgctcg gStaattttt tgtattttta gtagagacgg
agtttcaccg tgttagccag
|
27481gatggtcttg atctcctgac ctcgtgatcc acccacctcg
gcctccaaga gtgctgggat
|
27541tacaggcgtg agccacggcg cccggccaca aataattctt
taaagtacag gtttctgggc
|
27601cctactgaag aaatatggtt gaataggtca aaggtaggat
ctggaaacag gtacgctttt
|
27661gtaggcttcc cccaatgaac tcgatgagcg gcctggtttg
ggaatgtcta gtgtagtgga
|
27721aaaagcatgc atgacctttg ggatgagacc caggttcaaa
tcctgcctcc accactccca
|
27781cacctctctg agcctcagtt tcctcattgg taaaatggga
attatgacac tctgcaggaa
|
27841ttcttataag gattcaatga cagaagggga gccacatttt
agtgtccctc cttctttccc
|
27901tctaaatgtg gaatgaaaga aaaaggtttt gttttttact
gatgggaatt caaacttcag
|
27961ggtcacaagc taagaactat tttgaggtca acaagtcctt
cctgataaat gaaatcttag
|
28021tgcctgcttc ctcagagtta gtttgacttt tctgttttgg
ggccccattc taattttttc
|
28081gggtccctta aactgcagct tctaacaacc actaaaaagg
aagaccacct aatttcttac
|
28141ggccacaaac tcaaatacca ggggtttggt atgtgacagc
aggctgtgat gggaacagaa
|
28201agaaaatgga gctattcaca cagctccact ttattgcttc
cgggttgaag acagggccca
|
28261gtgttgccac ctcttctgga tttaaagaaa atggccggcc
aggtgcggtg gctcatgcct
|
28321gtaatcccag aactttggag gtgaggcagg tggatcactt
gaggtcagga gtttgtgacc
|
28381agcctgccaa catggtgaaa ctccgtctct accaaaatat
acaaaaatta gccaggtgtg
|
28441gtggcgtatg cctgcagtcc cagctacttg ggaggctgag
gtgggaaaat ctcttgaacc
|
28501tgggaagcaa agtttgcact gagtgacaaa gctccagcct
gggtgacaaa gtgagaccct
|
28561gtctcaaaaa aaaaaaaaaa aaaaaaaagg aaaaaggaat
aggctcagca gtagttctca
|
28621actagaggtg actttgttcc cagtatgaca cttggcaaca
tctggagaca ttttggttgt
|
28681cgctgttgtt ggggagctat gggcatctag tgggcagagg
ccacggatgc tgctatccat
|
28741gctacaatgc acaagacagc gcccctcccc caacaaagaa
ttatctggcc gaaaatgtaa
|
28801atagagccaa ggttgagaag ccttggacat ggttctgttg
cagcaacaac cctcaaatct
|
28861cagtggcttg caacaacaga ggtctcaccg cctgtccatt
gtgagtctga cagggatctg
|
28921ctttatgtca tcctcactca ggggcccagg ctaagggagg
tgccattccc atgcttgtaa
|
28981gatcttcgag gcaagtagag aatattaata tattattaac
attaattata ataataaaaa
|
29041ataatattaa ttacaatatt gatataactg ttaagttttg
tctagaagtg acatctatca
|
29101ttgccatcat attgcattgg ctgcacctta attcatgggg
tcaaggaagc acaatccatc
|
29161catgttcctg gatgcagaga attgggaata tttgctaaca
gcattaaaga ttccaaaggt
|
29221tgggtgcacc aaaacctcag agatcaccac taaagaactt
attcatgtaa ccaaacacca
|
29281cctgttcccc caaaacttat tggaaaaaac taaaaatcca
gagaaaaatg tatgctgacc
|
29341aaaaaaaaca aaaaaacctc caaaggtaat catgacagcc
tgggctctag gtaatccaca
|
29401aggctcagag aagggcagct aagggcacag gctgtggagt
cagacgtcag acttggcttc
|
29461aaaccccaca ctttctagcc atgtggactt gagcatgtca
cttaatctct cagtttcttt
|
29521ctctaaaaat gaggaaaata ggctgggcgt ggtggctcac
acctgtaatc ccagcacttt
|
29581gggaggccca ggcaggcgga tcacgaggtc aggagctcga
gaccagcctg gccaatatgg
|
29641tgaaacccgg tatctactaa aaatacaaaa attaggccag
acgtggtggc ccacgcttgt
|
29701aatcccagca ctttgggagg tcaaggaagg cgggtcacga
ggtcaggagt tcgagaccag
|
29761cctgaccatc atggtgaaac cctgtcttta ttaaaaatac
aaaaattagc caggtgtggt
|
29821ggtgtgagcc tgtaattcca Rttactcagg aggaagaggc
aggagaattg cttgaacctg
|
29881gaaggtggaa gtcgcagtga gccgagatta cgccactgca
ctccagccta ggtgacagag
|
29941tgagactcca tctcMcaaaa aaaaaaaaaa aaaaaaaagt
ctgggtgctg tggctcacgc
|
30001ctgtaatccc agcactttgg gaggccaagg tgggcggatc
acgaggtcag gagatcaaga
|
30061ccatctctac taaccctgtc tctaataaaa atacaaaaaa
ttagctgggc gtggtggtgg
|
30121gcacctgtgg tcccagctac tcgggaggct gaggcaggaR
aatggcgtga acccgggaga
|
30181tggagcttgc agtgagccga gatcatgcca ctgcactcta
gcctgggcga cagagtgaga
|
30241ctctgtctca aaaaaaaaaa attaattaat taaaataata
ataataataa ttaSctgggt
|
30301atggtggtgt gcgcctgtag tcccaggtac tcaggaggct
gaagcagaag aatcacttga
|
30361acccaggagg tggaggttgc agtgagctga gattgtgcca
ctgcactcag cctgggtgac
|
30421agagcgaggc tccatctcaa aaaaaaaaaa aaaaaaaaaa
acaagggaaa ataaatcaac
|
30481cttgcagtgt taaaatgctt agaacagtgc ctggcacaca
gaaacagctc aggacatgtt
|
30541agccaggatg atgatgatga tggattaggc caggcgccaa
tcacggagtg ggcatttagt
|
30601aaacagttgt tgttataacc taagctctga ggaaaatgac
ttgtccaagg taacacagct
|
30661ggtaagtgca gcatggtgga gaagagccta agctctgggg
tctcagcctg gcacatcgta
|
30721aatcataaat attaaataat atttggagga ggttcagtgt
ggttaagaac atggactcag
|
30781gccaggcacg gtggctcaca cctgtaatcc tagcactttg
ggagcctgag gcgggcagat
|
30841cacgaggtca ggagatcgag accatcctgg ctgacacggc
gaaaccccgt ctctactaaa
|
30901aatagaaaaa attagcccgg cgtggtggcg ggtgcctgta
gtcccagcta ctctggaggc
|
30961tgacgcagga gaatggcgtg aacccgggag gcggagcttg
cagtgagctg agatcgcgcc
|
31021actgcactcc agcctgggSg acagagcgag actctgcctc
aaaaaaaaaa aaaaaagaac
|
31081atagactcgg tagctcacac ctataatccc agcattttgg
gaggctaaca ggggcgcatc
|
31141ctttgatccc aggagtttga gaccagcctc ggcaacatgg
caaaactccg tctctacaaa
|
31201atatacaaaa attagccagg catggtgatg tgtgcctgta
gtcccagcta ctcaagaggc
|
31261tgaggcagga ggatcactta agcctggggg tgtcaaggct
gcagtgagct gagatcacga
|
31321cactgcactc cagtctgcgt ggcagagcaa gaccttgtct
caaaaaataa ataaataaaa
|
31381ataacatgaa ctcccgaggc tgactgccgg gttcaaatcc
tagctctact actgaccacc
|
31441tgtatgaact tgagcaagta actcagcctc tctgtgccca
gttttctcat ctataaaatg
|
31501aagctaataa taaaacacct gcaattagga aaattaaaaa
ataacattag taaagccctc
|
31561gggacccata tggttgttag ctgctacagt attactatgc
cctcagttcg ccacaaagaa
|
31621gcattcaaaa gtaacagaaa ataattaaca gtatcatttc
acccacccaa ttgagatagg
|
31681agagaagaaa atggatacaa attcagcaat ccttgagcta
agaaaatgtt tacagccagg
|
31741ggtggtcgct caggcctcta gtcccagcag ttagggaggc
tgaggccagc agatcacttg
|
31801agtccaggat ttcgagacca gcctaggcaa tgtgatgaaa
ctccatctct acaaaaaata
|
31861caaaaattac ctgggcatgg tggcatgcac ctgtagtccc
agctactcag gaggctgaag
|
31921tgggaggact ggttgagccc aggaggcaga agttgcagtg
agccaagact gtgccactgc
|
31981actccagcct gggtggcaga gtgagaccct atctccaaaa
aaaaaaaaaa gtttataaat
|
32041ggagcaatgg gaaaaaactt ggatgctttt Yttacctgcc
ccagggtagt cctagaaatc
|
32101agtgagaatt cccatttgtc ctcagagatt cctgcaacat
aggagtgcaa gagaggagac
|
32161agtaagcaga ggcacaaggc attactccca aatcacagct
aagccaccct gcaaccctgg
|
32221ccggctcctt acaaacccag ctcccttagc aactgcagtt
tcccatccaa ccagacgagg
|
32281gcgccgagct gacagtcttg ctgctggcaa tagtgatagc
cgctgtgaaa gcacagtaga
|
32341tgctcgtcca cttgtcgagg agaatgctga attcttacca
cttttgcacc actgtaaagt
|
32401cacaaagtca taagtcgaac caccataaac tggggattat
ccgcagtccc cccttatctg
|
32461tgggcgatat gttccaagac cctcagggga tgactgaaat
agtactgaac gctatatata
|
32521cagtactatg cttttttcta tacatacata cctatgatta
catttaattt ataaattagg
|
32581cacgatgaga ttaaacaact aataataaaa tggaacaatt
atagcaatat gatgtaatac
|
32641agttatcagg cactgtgctc ataacttttg cagtttcatg
tgtggcagca aaactagcag
|
32701gtatttcttt ttccttcttc ataatttcac agatagaaga
ttcgttctta ctacagatct
|
32761tagcgacctc agcacacttt attttttctt tccttattat
aacttttacc ttttcattta
|
32821aagaaagaac tttatggctt ctctttgcca tatccaaatt
gctagcatga Ctactcttgc
|
32881actttggggc cattattaag tcaaataagg gtgacttgaa
cacaagcatt gcaatatcac
|
32941ggcagtcgat ccgataacga acagggcact tacttagtaa
gtgactaacg aacagggagt
|
33001gtatacagcg tggaggcact agacaaaggg acgattcagg
ttccccaggt ggacagagcg
|
33061ggacagcaca agacttcatc acgctactca ggacagcatg
caatttaaaa tttacagatg
|
33121gtttatttct gaaaatttcc atttaatatt tttggacagt
ggttgactgc atgtaactga
|
33181aaccacagaa agcaaaaccg agtcaggggc aggggagggg
ggcggctaca gtaatagcct
|
33241ttccctgtgg accagatgtt ataccaaaca ctttcatgtg
ttatttcaca ttactgtcat
|
33301agcactccac aacataggta ctgttatgat tcccatttta
tgtaagacaa atctgaggcc
|
33361tagaaaaata aataaataaa aagaaaaaag aaaaaaatct
gagacctaga gaggttaagc
|
33421aatttgccta gcaggccaaa cctaatattt gcaggacagg
agcaagaata cagctgaatg
|
33481catacttaaa aagttataaa tgaccctaat gaactattaa
ataaaagaca atctattctg
|
33541ctatgtcaat aaataaacct tcacaatgac ctggaagacc
acattcacat ttttgggcct
|
33601ctcagagttc tgtactagaa ggtggtgaga ggcagagaac
aggacoctag ccctgcccca
|
33661ttctctccat atctctaaat ctgtgtgcct ggaagggYct
tgtgtccacg catgcagagg
|
33721tcctaacctg tgtgctcaca ctttgttcta ggggttctaa
attgaaaagg tccctcaggt
|
33781atccagcaca atgaatgaca aaagagacca aagcacaaca
aaaatcatca cattctagaa
|
33841taccaagaga agatcttaaa agcttccaga aaacggggtg
gggtgggggg aaaacccata
|
33901aaaagaatca ggattcagaa cagcattgta tttatcaaag
ccagaagaaa accagagcaa
|
33961tttcttcaca attatgaaag aattctatcc acagccaaac
tactaattaa gtacagtaga
|
34021ataaagccat tttcagtgcc acttaacatg tatggcagca
tggtagccag ccactaaggt
|
34081ggcctctaat gatttctacc tcctggtatc tgcactctta
tgaagttccc gcacacactg
|
34141aatatggctg acctgtgaaa ccatgggatg ttgcaaaatt
gacaatatgg gacttctgtg
|
34201gctaggtcat aaaagacatt ggtggtttct accttgccct
tagatcactt gttctgctga
|
34261aaaccagctg ctgtatcatg aggacactca aacagtacta
ttgagaggtc catgtgttaa
|
34321ggaactgggg cctcctgcca agagcctgca caaacttgcc
agccggggct tctccagccc
|
34381tggccaagcc ttcatatgat ttcaggctca tgagagaccc
caagccagaa ccacccagct
|
34441aggacgctct caaattccta actcacagaa actgtgagat
gataaatgtt aattgttgtt
|
34501ttgaggagag aggccatttc tcttactgtc tctgaagaga
aggaagaagt aaaagctgaa
|
34561aaacaacagg aatgaagtca gtggcaagac caactgatgc
cacttaccag gcctgaggtt
|
34621aaagattaac gcccccaccc taaccacatg tgttacctat
agatcacttg ctcaatctat
|
34681cacaaccctt tcacgtggac ccccttagag ttataagccc
ttaaaagggc caggaacttt
|
34741ttctttggag agcttggttc ttgagacaca actctgccaa
cgctcctggc cgaataaagt
|
34801ctcttccttc tttaacctgg tgtctgacag gttttatctg
cagcttgtcc tgctacagtt
|
34861ttaagccatt aagtttggga ataatttgtt acacaacaaa
agacaactaa tacagaccta
|
34921ctgggagggg aggagccaca gtattttgca gttcttccaa
tcaggaggtg aagtctacag
|
34981tctagctctc cactctagaa tttggatttg gctgatgggt
cattatagaa agattataga
|
35041tgtaaggctt aaaaagtgct tgtgctggca gggcgcagtg
gctcatgcct gtaatcctag
|
35101cactttggga ggccgaggtg ggcagatcac ctgaggtcag
aagtttgaga ccagcctgcc
|
35161caacatggtg aaaccccatc tctactaaaa atacaaaaat
tagccaggcg tggtggcagg
|
35221cgcctgtaat cccagctact cggaaggctg aggcaggaga
atcgcttgaa cccgggaggg
|
35281ggaggttgca gtgagcggag attgtgccac tgcactccag
cttaggtgac agagcaagac
|
35341tccatctcaa aaaaaaaaaa aaaaaaaaaa gtgcttgtgc
aattgagtct tgccctctct
|
35401tgctcctggg aactctgcaa ttatcaccat gtaatttagc
taggcttgtc tgctggagac
|
35461acgtggtccc atcatcccag ctaacagcca gcatcaagca
gacgagagtg agaccatccc
|
35521aaactttcca gcccaagctg aactggccca gaaaMgctaa
tccacaggat catgcgaatt
|
35581aatcaatgtt tgttgtttaa agctatcaaa gttttagggt
aatctgttac acagcataag
|
35641ctaattgata cagcatattt actttgtgtg cacctcccgc
ctcaacctcc ccaccctaac
|
35701caggaaacta ctgatgtgtt acaagaacac tacaggatgt
gttcaaagcc tggttacctc
|
35761ctaactttac ctagtctcag acaagttagt ttgcctcttt
cagcctcagt tttcctcatc
|
35821ttcaaattgg agataacagt aggtaatagc acctagctct
cttttttttt tttttgagat
|
35881ggagtctcgc tctgtcgctc aggctggagt gcagtggcac
aatctcggct cactgcaacc
|
35941tctgcctcct gggttcaagc gattctcctg cctcagcctc
ccgagtagct gggattacag
|
36001gcacacgcta cgatgcctgg ctaatttttc tatttttagt
agagacgggg tttcaccatg
|
36061ctggccaggc tggtctcaaa ctcctgacct caagtgatct
acccgcctcg gcctcccaaa
|
36121gtgttacagg tgtgagccac cacacctggc tgtacctagc
tcttaaagtt catgtgacaa
|
36181ttaattgaga tgaactacat aatgtgctta gcacacagtg
ctcaaataaa tcattaatga
|
36241aggcaacagg aaaaagccaa aatgagtaga tctccggggt
aaggcctgag ttggttcttc
|
36301aaaaggacac tcttaccaaa gaaaggctac caagtatatc
agtcaagtaa acatttactg
|
36361tttgccacat tccaggtccc ttacctgaaa ctgtgaccta
aaagcaggaa taattcacgg
|
36421cactgagcta ttttgaaaca gaaccaagct tgcttattgc
acaagtaact aaaataggac
|
36481atcaaaatat ttttcttgtt tttatttttt tgagacagtc
ttgctctgac acccaggttg
|
36541gagtgcagtg gtatgattac agctcactac agcctcaccc
tcccaggctc aggagatcct
|
36601tccacttcag cctcccaaat agctgggacc acaggcatga
gccaccatgc tgggctaRta
|
36661tttttaatta tttttgtaaa gatggggtct ccctatgttg
cccaggctag tctcaaactc
|
36721ctgggctcaa gtgatcctcc caccttggcc tcccaaaagt
gctgagatta caggcatgag
|
36781gcactgcatg tggcccagaa aatatttctg aatggaactt
gaaaaaatgg atattttggt
|
36841ctatacttca ccagccccac tgagcactcc agagccagat
gtgaagggaa gagggtagcc
|
36901agggtatccc ataactctct ttctgtatcc tgtcttttcc
ccaccaggga gtaggaaaac
|
36961attctatcct gaaaacaaga ttatttcacc tctaaacagt
gacttttaat tattttgatc
|
37021tcaacccaca atatgaaaaa cacatcatat tgtgtctgaa
tacaaactca aaactgaaac
|
37081aaaagtttca tcaattgaga cttgaaatgt gtgatacatt
ctgggttttt ttttttttgt
|
37141attctatttt ttttttaaat gttgatcaca attctctata
aacggatttt aaaacctatt
|
37201gacaggccac aaccagctgt tcgaaaaaaa gtactttgaa
atatcacatg ggggaggaaa
|
37261cgcagagatc atctagtcca atcccttcac ttcacagggg
gtaaactgag tctcagaaga
|
37321tcaagtcact tgcccaaggc cacgcagcta gtaagttgct
gtggttggat ttgaccgtaa
|
37381taaccatcgg ctactgaatg cccatcatgt gtcagccatt
tgctgagttt tttctttttt
|
37441tttctttttg agacagagtc ttgctctgtc gccaggctgg
agtgcagtgg cgcgatgtcg
|
37501gctcactgca acctctgcct cccgggttca agcgattctc
ctgcttcagc ctcccgagta
|
37561gctgggacta caggctcgcg ccaccacgcc tagctaattt
ttgtattttt agtagagacg
|
37621gggtttcatc atgttggcta ggatggtctc gatcttttga
cctcgtgatc cgcccgcctc
|
37681ggcctcccaa agtgctggga ttacaggcgt gagccaccgS
gcccggcctg ctgagttctt
|
37741taattgcatt atttcattta atactcactg tgatcctatg
aaacagatac tattctttcc
|
37801accttacaga cggggaaacg gagtctcaga ataggggaaa
tgacttaagg tgtcacaatg
|
37861gccagtagca gacccaggag tagtctttag gtctggccgt
gcacaaagcc ccatgctctc
|
37921aagctgtaac cccgctatca agaaagtggt tatgcaagtg
ggcctgtgag ctctcaacgt
|
37981ctaagccgtg cgcatgtgag acagcgataa gctcgcgttc
tccagtctcc agggccttat
|
38041cattcctcac gctttccttc atcggctcgc aaagaaacgt
ggcgatcaag gaagacagcg
|
38101aaggctccat cctcgtcggg ggaggataat tcgaatctca
gcctgtgagt ttactcagca
|
38161cacctgttta atctcttggt ccttcagttt ccacacctag
gaagctggaa cagcagcagc
|
38221atccagcgcc aggactggag tcatatacga actctggcac
ctgggaggcg cgcgtcctac
|
38281gtcagttccg ctcgacccca cccYccccgc ccccccgcct
tctccccacg cgcatgcgcc
|
38341gcgcagcggc gctttttacg acgcggcagg cgcggcgcgc
ttagttgccg gagctgaacg
|
38401gcgcggagct ggtctgaggc gagccgagcc gagcgagcgc
ggcggtgggg ccgagaggac
|
38461gcgcaggtgg cggcgttgcc atgtcgcacg gtcacagcca
cggcgggggt ggctgccgct
|
38521gcgccgccga acgggaggag ccgcccgagc agcgcggcct
ggcctacggc ctgtacctgc
|
38581gcatcgacct ggagcggctg caatgcctta acgagagccg
cgagggcagc ggccgcggcg
|
38641tcttcaagcc gtgggaggag cggaccgacc gctccaaggt
gggccgcctg gggcttgggg
|
38701cgggcggggc agggtgcgtg tggggcctcg ggccgtcggt
ctactcattt ctgatgttaa
|
38761gaataacgac agcctggttg ccaagcgctt ttccgtgcct
gtctcctgcc agctctttgg
|
38821gaggcgagca gcgttgtctc cccattttgc atatagggaa
actgaggcct agagggaacg
|
38881gggacagttt tgtcaagcta cacagcctaa cgctctattc
cagggctgtg tgggctagag
|
38941aggatggtcg tgagggccgt tggaccattg gtgctaatgg
ctgcctcatc atattacctg
|
39001gtgaagaYga gcctagggag atgaaaggtg gttcccatat
agagcaaatg ttctttacat
|
39061tgtggggtcg caggcccctt tgctatctgt ttgaaagcag
tggaccttct tctcagaaaa
|
39121atgcacataa acacctgcct ttcagttcac acttcagaag
gctcttcgac cctggaaatt
|
39181cattcatggg ctttttgtta agaaccttcc agttgggtgg
cctgtggctg ttatgacact
|
39241ggataagact ggttagcttc aagttaataa gtcttggaaa
accaagggag agtgactctt
|
39301cccattgcac cccagttgta gagcagggtg ggagatgcct
gaaattgtag gctctcagca
|
39361aatatttgtt gctttctcct cccccctccc catcccctcc
agtttgttga aagtgatgca
|
39421gatgaagagc ttctgtttaa tattccgtaa gtatctcctt
ggtgcctacc tcaggctaaa
|
39481taggctgtac ccagttgcct cagatggatt cattcactgg
tgtcaagagc acacatttgc
|
39541ttctagaaat gggataaatt actttggtgg gtttgaggag
gaaagcatca tagctttctt
|
39601ggtgcagact ggaaacagat gtatttgtag aacaataact
gagaaattga ggtagatttc
|
39661ttagaattgt agaatgctag aggtagacag gatcttagaa
attatctagt acaagttgac
|
39721agatgagtaa actgaagccc atacagggga agggtcttgc
ccagggtcac acaactaaac
|
39781aggtattcaa actcaggttt gacaaccttc tcttttgcat
tctggcagat ttacgggcaa
|
39841tgtcaagctc aaaggcatca ttataatggg agaggatgat
gactcacacc cctctgagat
|
39901gagactgtaa gtggcaaagg cttaggccct caaaggagct
cctaattctc tttttctggt
|
39961aacattttat tccagaatag tatcNtttNc ttcttaccgg
gtttaatatt tcccctttta
|
40021aaatatcttg gtcctgttct cattctgcat tggaatacat
atatttcttc ctgaattaat
|
40081gactttttta gattaagcat ctttaggccc aacagcgtgt
ctcatatttc aaagtgctta
|
40141ctatgacatg attcattcag agagcattgt gtaaatgtca
cttgttgatg actctgcagt
|
40201tttcttaata actagctgca gatctcatat gatctttatg
gattctaggg gttagcttca
|
40261acatttttcc ttgctatttc atacagtaat gatcttatgt
gttttgttga catggaattg
|
40321ctccacctga ctttgcgtgg catttagtta gcaaagttgt
gtatacctct tgcaacactg
|
40381aatcttttgc caccagagct agtacccttt ttgacaactt
accttattcc agaacagcct
|
40441tcctaaaaga aggggaaaac tgctttctga gtgctggaga
aacatataag aagaacttta
|
40501catttaaaaa attcagtccg ggtgcagtag cttatctcac
aaaaccaata aaagatgata
|
40561tataggctgg gcacagtggc ttacacttgt aatcccagca
ctttgggagg ctgaggcggg
|
40621cggatcacct gaggttcgag accagcctgg ccaacctggt
aaaaccccgt ctctactaaa
|
40681aaWacaaaaa ttagctgggc ctggtggtgc gtgcctgtaa
tcccagctac tagggagggt
|
40741gaggcaggag aattgcttga acctgggagg cggaggttgc
agcgagccga gatctcgCca
|
40801ctgcactcca gcctggatga cagaatgaga ccccatctca
aaagtaataa taaaaacaaa
|
40861taaataaaaa attcaaatcc taaaggccga gcatggtggt
tcacacctgt aatcccagca
|
40921ctttgggatg ccgagactgg ttaggagttc aagaccagcc
tgaccaagat gctgaaaccc
|
40981cgtctctact aaaaatacaa aaattagccg ggcatggtgg
cacacgcctg taatcccagc
|
41041tacttgggag gctgaggcag gagaatcgct tgaacccagg
tggcagaggt tgcagtgagc
|
41101caggatcgtg ccactgcact ccagtctggg tgacagagca
agactccatc tcaaaagaaa
|
41161aaaataattc aaatcccagc actttgggag gccgaggcgg
gcggatcact tgaggccagg
|
41221agttcaagat catcctggtc aacatggcga aaccctgtct
ctactaaaaa tacaaaaatt
|
41281agctgggtgc ggtggcacag gcctgtaatc ctagctactg
gagaagctga agcatgagaa
|
41341tcacttgaac cgcggaggtg caggttgcag tgagccaaga
ttgcaccact gcattccagc
|
41401ctgggcaaca gagtgagact ctgtctcaaa aaaaaaaaaa
aaaattcatc tgaaaaattg
|
41461attaaaggac ttccagagat ttaagatata ttatagttga
gtattagaaa catgaatttg
|
41521aaagcaaatc catgtattta atcattttaa ggaaataata
cctttgatgc ttttggagac
|
41581tcatttactt ggaagttgat ggactgacct gagaatatta
ggcatccatg ctgcattgtg
|
41641atttagagtg tgggatctgg agtaaactgg gttcaaataa
tggctgtacc acttgttagc
|
41701ttcatgactt tgagacctta tcttctctat gcctggattt
tctatatcta acatgggaat
|
41761ggtaacagtg catacatacc tcataagatt gtggagaggc
ttaaatgaga taaaacatgt
|
41821aaagagctta gattaggtct ggaacacagt aagtgtccaa
ttttgggtga acagatacga
|
41881atacatagcc ctcagttcta agcacactac atatattata
ctttatcaaa tgtaagatgt
|
41941cattgattgt aaaatgtacc attatattca attaatacag
aaaaaatgct attgaactat
|
42001gacatgtcat tgacacatcc agaaaaatta gattgagagt
attaaatcag ggaagtttga
|
42061acacagatga ggtgttacat gttactaaag aattaccatt
cagccaggcg cagtggctta
|
42121cacctataat cccagcactt tgggaagccg aggcaggYgg
attacctgag gtcaggagtt
|
42181caagaccagc ctggccaaca tggtgaaacc ctgtctctac
taaaaacaca agaattagcc
|
42241agtcatggtg gcagtcgcct gtcatcccag ctattcggga
ggctgaggca ggagaatcac
|
42301ttgaacccgg gaggcggagg ttgcagtgag ccaagattac
tccactgcac tccaacatgt
|
42361gtgacagtgc aagactctgt ctcaaaagaa aaaaaaaaaa
gaattaccac tgggctgggc
|
42421acagtggctc atgcctcaat cccagcactt tggggaggcc
gaggcgaaag gatcacttga
|
42481gcctaggaat taaaggttat ggtgaattaa gatcgtaaga
tcatatactg gaccccagcc
|
42541tgggcaacag agcaaggctt aaaaaaaaat tatttatata
gtttgagata gggccttact
|
42601ttgtcaccta ggctggagtg cagtagtgtg atcatagctc
actgcagcct cgacctcctc
|
42661agttcaagca atcctcccac cgcagcctcc caagcagctg
ggaatacaga cgtgtgccac
|
42721cacgcccagc taatttatgt atttttttgc agagatgggg
ttttgttatg ttgcccaggc
|
42781tggtcttgaa ctcctgggat caagcaggct gcccacctca
gcctcccagt gtgctgagat
|
42841tacaggagct agccactgca cccagccaaa aaaaaattta
aaaaagtgaa ttgctgttaa
|
42901ttttgttatc tgttgatatt gtcaattatt gtaaaatggt
attaaatata tgtattttat
|
42961tttattttat tttatttttg agacagagtc tcactgtgtc
gcccaggctg gagtgcagtg
|
43021gcgcgatctc ggctcactgc aagctccgcc tcctgggttc
acgccattct cccatctcag
|
43081cctcctgagt agcggggact acaggtgccc gccaccatgt
ctggctaatt ttttgtattt
|
43141tttagtagag atagagtttc actgtgttag caaggatggt
ctcgatctcc tgaccttgtg
|
43201atccacccac ctcagcctcc cgaagtgctg ggatcacagg
cacatgtgtg tatatatata
|
43261tgtatatcta catatatacg catatatata tacacatata
tgtgtatata tacatatata
|
43321cgcatatata tatacacata tatgtgtata tatacatata
tacgcatata tacacatata
|
43381tatgcgtata tatacgtgtg tgtgtgtgtg tgtgtgtgta
ttttttgttt ttttaagacg
|
43441gcgttctgct ctgttgccta ggcttgagtg cagtggccca
atcttggctc actgcaacct
|
43501ccgcctcctg gggtcaagcg attctcttgc ttcagcctcc
tgagtagctg ggattacagg
|
43561tacacaccac caggcctggc taattttttt tttattttta
gtagagacag ggtttcgcca
|
43621tgttgaccag gcagctctcg aactcctgac ctcaagtgat
ccgcctgcct ccgcctccca
|
43681aagtgctggg attacaggcg tgagccacca cgcctggccc
atactggaat atttataggt
|
43741gaaatgatgt gtctgggatt gctttaaaat attgagctta
agcaaaatca ggctgatagg
|
43801caagatcaac aaaatgttga tcatcgaaga tgagtgaaaa
gtatgtggag attcattatg
|
43861taatctctgc ttttgtgtaa gtttgaactt ttccatagta
aagttttttc aatatatgcg
|
43921ttacttagaa tcgattcaat ttcatctcca taccaaccgt
gtggaatatg tactattacc
|
43981attcccattt tacagatgag gaaacagagg ttaaatcagg
tgcccaaatt tactcagctg
|
44041gtaagtgaca gagccaggct tgaatcctag aaagtctagc
tctagatttt aactacagcg
|
44101ctatactgct tctcattatg ccgctcataa atgtttacta
ttattattat tctgtggtgc
|
44161atcattctta gaaacacttt gaagtaaaca tttgctttct
tttttttttt tttttttttt
|
44221tttgagacgg agtctcgctc tgttgcccag gctggagtgc
agtggcgcca tctcggctca
|
44281ctccaagttc cgcttcccag gttcatgcca ttctcctgcc
tcagcctccc aagtagctgg
|
44341gactacaggc gcctgccacc acgcccggSt aattttttgt
atttttagta gagacggggt
|
44401ttcaccgtgt tagccaggat ggtctccatc tcctgacctc
atgatctgcc cgcctcggcc
|
44461tcccaaagtg ctgggattac aggtgtgagc cactgcgccc
ggSggctttc ttaaattaca
|
44521tgcattttgc cccagctaat atcgaggcct cttctgtgtg
ggtgtgtcaa taaaacaccc
|
44581tggaattggt ggggacatgt ggcttagtct ttgggaattt
gtgggttata gagacagctg
|
44641ctttttagat tactctttga aaaacatttt cttctctagc
agtttacttt ttatttattc
|
44701tgagacagag tctctctgtc acccaggctg gagtacagtg
gcgtgatctt ggctcattgc
|
44761accctctcta gcggtttgga tgtgagattg cagtcttttg
tgatctttca aaatggaaat
|
44821cctcatgtta taaatgtttt aagaactgta aggtgactga
gtgtatggcg tggtttttgg
|
44881acacaaaaaa atgcttgagc attgggttac ctgatctttt
atctcttaac tgtgtgtaat
|
44941atgtttctgc caaagtatgt atttttccca tgagtaagct
gttttattta ataacatcct
|
45001cagtttggtc tgaatgtgct gagttgttta ttttctccat
gcatttgctg catgtgacct
|
45061agtttgagcc gtctctttgt gtattgcttc tcatgtgata
ttaacccact caaagatgcc
|
45121atggggttat gttgcagatc tcagctcttt ttttgttgga
ttaaagatat ttgtaggcta
|
45181gacgcggtgg ctcatgcctg taattccagc actttcggag
accgacgtag gcggatcacc
|
45241tgaggttggg agttagagac cagcattgcc aacatggtga
aaccctgtct ttactaaaag
|
45301taccaaaatt tgccgggcat ggtggcgtac gcctgtagtc
ccagctactc aggaggctga
|
45361ggcatgagag tcacttgaac cYgggaggtg gaggttgcag
tgagctgaga ttgtaccatt
|
45421gcactccagc ctgggtgaca cagtgagact ctgtctcaaa
aaaaaaaaaa aaaaagatat
|
45481ttggagatac ttgtataaaa tgtcatttct aaaatatgac
ccccaaattc agtctcctat
|
45541tgatagaacc aaagccattt aagcagtcag tagaaaattt
tgaaaacctg aaacgtgata
|
45601atgcacattt cttgactttt ctttcctttc ctttctcagg
tacaagaata ttccacagat
|
45661gtcctttgat gatacagaaa gggagccaga tcagaccttt
agtctgaacc gggatcttac
|
45721aggagaatta gagtatgcta caaagtaagc actgggcctg
tcttccattc tctatggctt
|
45781cttatagggc ttgccattta tttttggcca gtctcctgct
ctcttagcat tggaaatgag
|
45841ttaaaacagt ggaggagact tgatctttgg cttggtcagt
ttttggcaga gattcagtgc
|
45901aagccacaga cttgttaact tgcaagcaat tggcagatct
gaatgaactc ctagggtggt
|
45961tttaggaaag atgtgtctcc cattagttta ggttaacact
aaatgtgctt tagaatccct
|
46021gctgggttat gcagcatttc tcattcctgt tccttgaggg
caggagcagt gtttatccct
|
46081actgccttgg acaggatctg gcaggtgctc agtaaatggt
cattgaatta attgcctgtc
|
46141caaaggagaa ggaagaactc aggagctctg Mctttgcctg
gcttttacaa gctggagctg
|
46201aattgttgtt tcacatggtg gtgagatact cattgaacta
taattcatac cttctttccc
|
46261tattcctgtc atcctctaga atttctcgtt tttcaaatgt
ctatcatctc tcaattcata
|
46321tttcaaaaaa cttcggagca gatacgacaa aggtctttta
tattggcctg agaggagagt
|
46381ggactgaggt aagatggggt tggaaaggtt ttcccctcat
gtctacatat ctgcacactg
|
46441tggtgatggg agcttccagg gaagggaaaa gagcaagtgt
cataattact cccagtttat
|
46501tatttttctt ggttttatca gtataaactt ttcgtctcat
ttgagaaact acaggtattt
|
46561ttaagggggt tgaaactgtt atttttatat aaataatata
tataatatat atatatatat
|
46621ctcagctcac tgcgacctcc gcctcccagg ttcaagtgat
tctcctgcct cagcccccca
|
46681agtagctggg attacaggtg cocactocca cgcctggcta
atttttttgt atttttagta
|
46741gagacagggt ttcaccatgt tggccaggct ggtctcgaac
tcctgacctc aggtgatctg
|
46801cccatctcag cctcccaaaa tgttgggatt acaggtgtga
gccaccttgc ccagcctgaa
|
46861attgtcattt atattaattc acagttttct actttcaaat
gctttcattg agtatttttg
|
46921ataatctttt ctattcatga accagggata agataatacc
atagacaagt tcctattctc
|
46981atggtacccc cattatagta gggagactga atcttcaaag
ttacagggtg aatcaatgat
|
47041aatgatcttt gcagctttct ggagttaaaa agtatcaaaa
ttgggagata ttagatgatg
|
47101acatctaagt attaaaataa ggagatatta aatgatgact
cctagaaatg aacctgaata
|
47161aggactaccg caatgtgtgt ggtgtgggaa aggacagttc
ttttaatggc tggctgaccc
|
47221agcctcaatt ttcttgcagc ttcgccgaca cgaggtgacc
atctgcaatt acgaaKcatc
|
47281tgccaaccca gcagaccaYa gggtccatca ggttacccca
cagacacact ttatttccta
|
47341agggctggcc aaggctccca tagaggcgct gtgtcagtga
agatgtacga ctacctgttg
|
47401ggaaggacaa agggatgagg ctccagagag agttggctgc
cacagcctct gccaagcttt
|
47461gtctttgggg cttgctgcag aaacctggcc tacggaagat
acgacaccac tgggagggtt
|
47521gtgtaggtgc caggggacca tcgtggttct ctagggcgct
gtggaaattg ggtcttgggc
|
47581tgggtggcat ctggcagtca tggRtaacac ttgcttttcc
agttaatgtg gccatgtgat
|
47641tccaagtgtc atgttgcttt gtggcaagat tgttgtgtga
cttgtttttt tgtttttgtt
|
47701tttgtttttt taaaggaaac tatttgtggg ctataggaaa
ctttctgatg cctccggatt
|
47761gtgttagtag tagccatcag gagggtctcc aactaaaaca
cttgttcctg cttgctcctt
|
47821tcccctctca ttgttcagca ttcttgtcaa gttgcccagc
ttggagttgt ctgtcacgca
|
47881catgtgtcct gtggttatag ctagaaggac aggagtctcc
tgctgatgcg tgatagctta
|
47941agcttgggga gaaggtcttt tccactgcct agctaagcag
tctggggaga gcatggggat
|
48001catttctatg tgtgtgggta atctggtcag taagattgag
acttagttaa gattcccctt
|
48061ggaaattcct taatgtttat tagcttctaa ctagtgttgt
aagtccgatg ccagaatttg
|
48121gagatttgag ttcttctttt catggctttt attcactgtg
actaataagc ttcctaataa
|
48181atccttgcca gacttaatgt ttgtattttc ttttgagttc
ttgatagcca ctgatgcaac
|
48241tttcatttca tggggaactg tactgaactt tgaaattttt
tgttgttgtt ttggactagg
|
48301tagattatag gaagtgccac aattaaatca agactggagc
cgggcgcggt ggctcacgcc
|
48361tgtaatccca gcactttggg aggccgaggt gggcggatca
cgaggtcagg agatcgagac
|
48421cacggtgaaa ccgtctctac caaaaataca aaaaattagc
cRggtgcggt ggcgggagcc
|
48481tgtagtccca gctactcagg aggctgaggc aggagaatgg
catgaacccg ggaagcggag
|
48541cttgcagtga cctgagattg caccactgca ctccagcctg
ggtgacagag tgagactccg
|
48601tctcaaaaaa aaaaaaaaaa aaaatcaaga ctggatcagt
ttctccagga atggtcaagc
|
48661ttaattttgt acagtaggcc aaaaacactc ctacacccat
atatagtaaa gaagaaggtg
|
48721gggttgaaaa cctgtatttc acagaaatta actgggcatg
gtggcgtgca cctgtagtcc
|
48781cagccacttg ggaggctgag gtgggaggat cactggagcc
caggaggtcg aggctacagt
|
48841aagccatgat tgcgccactg caccccagcc tgaggcaaca
gagtgagacc ttgtctcaaa
|
48901acaacaacaa caaaacccta tatttcattt tgcacaaaag
gaagtgattt gtagaatgac
|
48961atttacaaaa ataagggaga acagattttg gagctcatca
gaagaaatga gggtgaggaa
|
49021agtaattgag cagctcatgt ggtctccagg tagaccaaag
actttggact taaattttga
|
49081aagtcagttt agcaattgaa gagaatgtaa gtatctaaaa
aggggatttg atatggtcag
|
49141tattctctcc cttgcagaaa acaggaacag gtaataaagg
gaattagtgt tgaatctgat
|
49201ccttttggga gaattcctct gaggcattgg cccatgctgt
tgtttggagg atatagccac
|
49261tgtttctcca gcctgtccta ggaaaggtct gotaccacca
aaccttgttg gccctcaaaa
|
49321tttctaaaat gcagcctgaa ataaaccaga atgcaaatgc
tgttcttgaa aagcatgaag
|
49381ggtcctattc actcagccac agcctcttta tttcagttgg
atcatttttt ggagttaaaa
|
49441gaagggctat gtttaaattt ggagtagggg gaaaaataaa
gttaaaaatc ttagagcaga
|
49501ctagcccttc actaattcca ctaattaaag cattaatcac
agctcctggg actgagcctc
|
49561tgaatttgaa gcttcactct gaagaatttg ttttaagtgt
catggtgtct caggtgatcg
|
49621aggttgcagg aggaactgtt cattcttcca taagtgggga
cattaccctc cattttcttt
|
49681tgacattcag tcctgggtcc ttggcttgtg gtggtcccat
aggctcaaag gtttcctgcc
|
49741ccgaatcctg gtattgtagg ctccctgacc tgttgagtac
ttaggaccaa agtgcctctg
|
49801ggcctggggg aaagtgcttt gttgagcttc caactttgta
ctgttttctt tttcttttct
|
49861ttcttttttt tttttttttt tttttgagac agagtctcgc
tttgttgccc aggctggagt
|
49921gtagtggcac tatcttggct cactgcaagc tccgcctccc
gggttcacgc cattctcctg
|
49981cctcagcctc cccccgagta gctaggacta caggcgcccg
ccacagcgcc aggctaattt
|
50041tttgtatttt tagtagagac agggtttcac cgtgttagcc
aggatggtct cgatctcctg
|
50101acctcgtgat ccgcccgcct cagcctccca aagtgctggg
attacaggag tgagccaccg
|
50161cgcctggctg tactgttttc tttctgttca aagaaaacac
tagtataggt taggctggga
|
50221gagtgagtcc taagcggctg agggtcaagt gtgactcatt
tcctatttgc agatccccac
|
50281acattctcag ggacatgctc cttcaactca gtttgcctgc
cttctgactt ttctgtggtc
|
50341cctgatacct atttccactt cagcttgatg gcagcgtttt
gtgcactgtc tgcatgacat
|
50401tgcttgtgaa gggcagcgct aacactgcca gtgcctgtcc
agctctcctg atacggcctt
|
50461tgtatttttc ctaggtcctt ttttgcgtga ttaacacctc
acgctgtgat tttactgtat
|
50521aaaccatgtt cacacaacct catttaagcc taccaacaaa
gctgtgaagg aggcagggtg
|
50581gttattacca ttttatatat caggaagcag atccagagag
gcagaattta aatggaatcc
|
50641cgaggttgct gtttacatgc cttccttgag cctcagtttc
cccatcttca aggctggaga
|
50701actagatgat ctgtaaggtc tcttcggttc agagtgtgtc
attccattca tgatcctgga
|
50761atagggcatg aaagccagtg gcagaMaccc gaggccttaa
gaggtgtgtc ccatgaggat
|
50821gggaaggtgg taaagtttat gcaaacaata gtgtgaggga
tgcctctcct tccggtcggc
|
50881cctcctccag gaggcgcatg ggtggtggta gcaagtggga
gtcttgggtg ccctgtctcg
|
50941aatctacaag gtgggagcgg gtgagaaccc agcgactgcg
cggctgaatg acagggagta
|
51001gccccgccgc ctccaacatg gcagcttcta tccagcgaag
ccgggtcccc gcttccKggt
|
51061tccgtactgt cggccaggct acttccggca gcgcgatggc
tgggttcccg ggactcgaac
|
51121ggaagttccg gcgggggcgg ccgaggggga agagtgtgtc
tgcgggagaa agaggagaat
|
51181cgcccaagcg gcctcggaag tcccagggag tggaggtacc
cagccggcgg CtgCggagga
|
51241tgggcgtgta gggggaggtc ggcctcggga gggtcccgga
gagcggggag ggggaaccgt
|
51301gatggggggR atgggggtgg ggagtgaggt gcgaaggcgc
tgtccagtct tggggacttc
|
51361gggagtggag cggggctagg caagggggtg tctgagtata
aagagacaga cttcagggtc
|
51421ggaaatagaa gagcccattg tggggcgggg gcttccccag
agtcaaaggt acaaagcttt
|
51481attgtgggca ggtgggagtc ctgggtcagg gtagaaaatt
tcactgggta gggtgacctt
|
51541tggtcagaac agaagttccc attgtgggga gcgggagatc
ctgggtcagg gtggaagttc
|
51601tcaaggtgta tagagagaga caggtcaggg ggaaggcacc
cctccgagga gggagcctgg
|
51661gcgggaggtg caagtcccca cggtggagaa ggaagggaat
cgcagctcag ggcaggaggt
|
51721gcattcccca tgggaagagg aaccccgggt cacaggtgaa
cgatcccatt gtggggagct
|
51781gccctcaggg gtcagagatg gaaggtgagg ccagttggga
ggggtgggca ggcacttgag
|
51841gcaggtagtg gaagcttccg gcgagtttgg aggacgccga
ggatggggag gggccagcca
|
51901gcctgacatt cttttgtgtg tttgggagtc ccagagcgtg
gtcaagccag ggctcgtttg
|
51961cagtcagtgg cagcagcagc aggtagctcc gtttaNgggg
ggcgtggagc accagtttgg
|
52021gggtgggtgg agttcttacg ctttctgggg acatgggcag
ccccctgggg gtctgggaat
|
52081ggatgggcca gaaactgctg tgaaggctgg atgggggctg
ggtgggggga ggttgagatg
|
52141ggggttggag gcggcactga gtaggggatg gaagctcctt
tccctggcac ttttctctcc
|
52201atttcccata gggcccggag ttggggaggc agggacccag
ggatgattgg agaggagggg
|
52261gaaggcactc acccctgagg agttagaggg ggaatgaagc
aggcgtgccg ctgcctcccc
|
52321tctgccccct gccctacagt ccctatgccc tgcctctgcc
tgtctccagc aagctcaggt
|
52381cctgtggttg ggccagaacc agagacacat gttctgggcc
actagggagg ctgtctctgc
|
52441ctttcagccc tggaactgag gcagacttct tctcctgtgc
cctgggactt cttgcttgac
|
52501tattctttgt gcccaggaca gaacctgggt gctgtgtggg
gctgaKggcc tggtggcctc
|
52561ttgggccagg agtgtgtcct gtgcctggtt ttgctcttga
cYgccgcccc gatgtatgca
|
52621ggcccccgcc gtggagccgt gtggtgtatg tgtggtaaca
ccatgtctgt gcccctgctc
|
52681accgatgctg ccaccgtgtc tggagctgag cgggaaacgg
ccgcRgtaag ggtccccttt
|
52741cacccacggc cagacactgt gggagcagct ggaggaccgg
ctggaggggg tgtgggaaaa
|
52801tggaggtggc agtgatgagc agggagtatc ctgaggccag
caggctcggg gtagtaaMct
|
52861gtttggctgc tacctgggtt cccccaggtc cttgggggtg
ggggaggggt gggcagaagt
|
52921tggaggacct agggKaagcc ttcctgtYtc cccatttccc
atccttttcc aggttatttt
|
52981tttacatgga cttggagaca cagggtaagt gactgaggag
gggtgctcct taaggagggg
|
53041tcctggccca gcagcggact ggagaggcct tctcttccta
ccacatcgga gccttttctc
|
53101cYgtccctcc tacaggcaca gctgggctga cgccctctcc
accatccggc tccctcacgt
|
53161caagtacatc tgtccccatg cgtgagtgtc accccagcaa
gggaggggct gaggctgggg
|
53221atcatctggg ggtggtcctg tcatcccagg cctgttctct
cctgtcagtt gcatcctggg
|
53281gcttgggctc agggcagtca gaagtggcat tttcagcctg
agctcctgtg gagcccccag
|
53341gagtggggtc cagcaccagc ccccagccct agggcctcct
agacctgagc tctcctagaa
|
53401cccacacctc cctttgcccc ttccccaagt actcaccgac
tacctgggac cccgtcacac
|
53461caagcgctgg gctctgcttc tccattactg gcgctttgcc
ccaaccacag cctccagccc
|
53521cacgtggcag gttgcctggc aacaccttaa acacaggccc
tgcctgctgg gaggggccac
|
53581caggggcggc gcggccccac tccgggctct gagctctggc
ctcctcattc ctcctgagca
|
53641tgatgggccc tctggctctc tttccccagg cctaggatcc
ctgtgaccct caacatgaag
|
53701atggtgatgc cctcctggtg agtttgggag tgggggtggg
cagggggacg aggacacttg
|
53761ggctgaggga gccacagggg gctggctggg gttttctata
gctgccagtg cctctactcc
|
53821caaggtttga cctgatgggg ctgagtccag atgccccaga
ggacgaggct ggcatcaaga
|
53881aggcagcaga gaacagtaag accccagccc ctcctccaca
tcctccttcc cctgcccccc
|
53941aggaaagcgc tgggcggttc ctcagcctag ctcccttatt
gggccccttg gcagcttccc
|
54001tctacccact catgccccct cccccagtca aggccttgat
tgagcatgaa atgaagaacg
|
54061ggatccctgc caatcgaatc gtcctgggag gcttttcaca
ggtgagggga gaggggtggg
|
54121ggggtagggg gtaggggtgg ccggtgagtg agctgtgccM
tcatgacccc tctctctcct
|
54181ccctccaggg cggggccctg tccctctaca cggccctcac
ctgcccccac cctctggctg
|
54241gcatcgtggc gttgagctgc tggctgcctc tgcaccgggc
cttcccccag gtgaatgtcc
|
54301ccactgaccc ccccgccctt tgtgtctgca tcctcgtggc
ttggggactg ctgcagcact
|
54361agctttgccc tgagtcctgt ccggcctcca ggcagctaat
ggcagtgcca aggacctggc
|
54421catactccag tgccatgggg agctggaccc catggtgccc
gtacggtttg gggccctgac
|
54481ggctgagaag ctccggtctg ttgtcacacc tgccagggtc
cagttcaaga catacccggg
|
54541tgtcatgcac agctcctgtc ctcaggtcag tggggggacc
atttcccact cccacttctc
|
54601tgcctccagc caggtgcctc tcgtgatccc ctcttaatcc
cctcaggaga tggcagctgt
|
54661gaaggaattt cttgagaagc tgctgcctcc tgtctaacta
gtcgctggcc ccagtgcagt
|
54721accccagctc atgggggact cagcaagcaa gcgtggcacc
atcttggatc tgagccggtc
|
54781gagcccctgt cccYaccYtt cctgacctgt ccttttccca
caggcctctg ggggcaggtg
|
54841gcaaggcctg gcYgggcctt ccttcctggc cttagccacc
tggctctgtc tgcagcaggg
|
54901gcaggctgct ttcttatcca tttccctgga ggcgggcccc
cctggcagca gtattggagg
|
54961ggctacaggc agctggagaa aggggcccag ccgctgaccc
actcactcag gacctcactc
|
55021actagccccg ctttgggccc cctcctgtga cctcagggtt
tggcccatgg ggccccccca
|
55081ggcccctgcc ccaactgatt ctgcccagat aatcgtgtct
cctgcctcca ctcagctgct
|
55141tctcagtcat gaatgtggcc atggccccgg ggtccccttg
ctgctgtggg ctccctgtcc
|
55201ctgggcagga gtgctggtga ggaggtggag ccttttgagg
ggggccttcc ctcagctgtt
|
55261tccccacact ggggggctgg gccctgcctc cccgttaccc
tccttccctg caggcctgga
|
55321gcctgtaggg ctggactgag gttcaggtct ccccccagct
gtctcacccc cactttgtcc
|
55381ccactctaga gcagggaggc agtgggggag gagttgtgtc
tYgtcttctg tctccatgtg
|
55441gtttttgggt gtttttcttS ttgtgtcctg gattccgata
aaattaaaga aattgcttcc
|
55501tcaacgctca ggcctggctg attctattcc aggggtggat
agtgaccatc tgtgagaacc
|
55561tgccccagtg taagaaaact tgtttttatt tttaaatact
ttggaaagct ctttcagagc
|
55621aatataaatg agtgcctggg aggaKgaggt tttgtgccaR
agccttgccc cctcactcac
|
55681tcttgggggt cctgatgaac tcttggaccc tgtggaagat
aagagttaRa gacctMggcc
|
55741tcctggtcag tggagccctt ggcctcatgc ctggtgggct
aagcgggccc agctggggtt
|
55801tgaggtaggg gaggccttgg Yttggcccca gcagctccag
ggccctgagt tcctgccaga
|
55861ggctggagag caggcagctg ctgcttttcc tggtccttgg
taggggaggg tcctcaggct
|
55921tgcgtgccaa agcctgaagg attctgcttc tgccagcgcc
agagatcctM acctgcaaca
|
55981cggcgaggtg tgtgctcagg gcccacggtg gaatgcagag
cctcccccac cccacagccc
|
56041gccctgggtg ggcatgccca gatctgattt agcccctccc
tggcccctaa ctgcaggggt
|
56101caggccagca ctcacacatc ctgtccagcc ctaaggctgc
tgtccacccM agctcctctt
|
56161gggccaRgct Kgggttggcg taacaggctg ccacatcacc
ttcccgccgK gcMaccacct
|
56221tgtacgggat ctgcaagaca ggaggtagtt ggagcttaKc
tgagccggcc ctggcccagc
|
56281tgctggccag gtctttaaga agcagaagtg cagagcagcg
gctggcccgc aggcaccggg
|
56341tgctaggcag gctgaggaga ctgggcagtg ccaggtaccc
tccagagagg tgagtgggaa
|
56401gggccaaagc tgctctgttg ctgagagctg ggtggggtga
ggtgggtgag gtgggtgggg
|
56461Ygggggggcc taccttcttY ccagaRgcct tctccataRc
ctggaccatY tgcagcactg
|
56521aatagcctgt gcccgtgccc agKttgtaga tctggcccac
ggagaacagg gtttatggag
|
56581cgggctggac tgaccacgcc tctgggccgc tctgcctgga
tctggtccct cccctccctc
|
56641acttctccct tctcttccta cccggcagcc acactgttct
ttcagcttcc ttaaggctgc
|
56701aatgtggccc ttggccagat ccacgacatg gatgtaatcc
cggacacctg cagagaaggg
|
56761agtgtgttgg atggggagtc tgttccccct gactctcctt
cctggctccc actcctaggt
|
56821ccccctSgtc ctaggctcac ctgtgScatc ctctgtgtMa
tagtcattgS caaagacatt
|
56881cagggcctcM cgtcgcccga tcgccaMctg gaggtggaga
tcaggtcagt tcgtcccaga
|
56941tcccaggcac cagctttaac cccagggcca ctcctctgtc
ccttcccttt tgccttacct
|
57001gggagacata aggcatgagg ttgttgggta tgccctgggg
atcctcacca atgcagccag
|
57061aggcatgggc acctgtgggg ttgaaatagc gcagcagcac
tgcgttccaa gtctgtggga
|
57121tgtgggtcag gtggtgaggc cagaggcaca ggcagcgtgt
cccagctgaa cccagagccc
|
57181tcctcatgcc tattctgttt ttttgagatg gagtctcact
atggcccagg ctggagtgta
|
57241gtggcctgat ttggctcact tcaacctctg ccttccaggt
tcaagcaatt cttgtgcctc
|
57301agcctcccga atagctggga ccacaggcac acaccaccat
ggccggctaa tgtttgtatt
|
57361tttagtagag atgggggttt taccatgttg tccaggctgg
tcttgaactc ctgacctcag
|
57421gtgatctgcc cacctgggcc tcccaaagtg ctgagattac
aggtatgagc cactgcgccc
|
57481ggccagttgt ctatttatta tctttagaaa caagcagggg
atggggccct ccactgcaac
|
57541tgcctgagcc ttagcttcct ccttagtggg ggtgttcgga
atcccacccc tgggctcagg
|
57601gtgggccctg aggagtccat cgatcagtgg agccagggca
ctgtcaaggg ggccctcacc
|
57661ttgtctgcct ggcacaggtc ccggatcatt tcctcgatga
agaacttgga cttgccgtaa
|
57721gggttggtac aaccacccgt ggggtgggcc tcatcaaggg
gcaggtRctg ggggttcccg
|
57781tacacagtgg ctgagctgct gaacaccagg ttcttcaccc
cgtgggcctt catgatctgg
|
57841ccgtggagag atggcatcag tgacctctgc ctcacacatt
actcccaccc tgttactcct
|
57901ccacaggaga atggggctga ggtgatgagc actctcattt
acagatgggg aaactgagac
|
57961tgggaggtaa agacatgagt ccaggatgat acagcttggg
ctctgtgttt ggcactgcct
|
58021gccaggctgg ggtccagctg gacaccctcc tagtgtctgt
gccctgtccc atgcctctca
|
58081cctccagaag ctggatggtc ccggtcaggt taactctgta
ataatccaga ggcttctgca
|
58141ccgactcgcc cacggccttg agccccgcaa agtggatgac
cgccataaag ctgtactgca
|
58201ggggtgacat ggccagaggt tgctctactg gttttagtcc
ttggcaatgc cctcagcctg
|
58261cctgcctgca ctcacctttt tttttttttt tgacagtctc
gctctgttgt ccaggctgga
|
58321gtacagtggt gccatctcag ctcaccgcaa cctccacctc
ccaggctcaa gccatcctcc
|
58381catgccagcc tcccgagtag ctgggaccac aggtatgggc
taccatgccc agctaatttt
|
58441tgtatttttc tgtagagatg gggtttcact gtgttgagca
ggctggtctt gaacacctgg
|
58501gctcaagtga tctcctcacc tcggccttcc aaagtgctgg
aattacaggc gtgagccacc
|
58561gtgcccagcc tgcacccacc tttttgaaga gacgctgtag
ggctccctgg tccaaaatgt
|
58621ccatctcctc aaactccaca gagcggcctg tcagctcctg
gacccgccgc aggctctcag
|
58681gcagggagcc ccctcctggt agggtacatg taggccacat
catcacgaca tggggtgctg
|
58741tgttcccagg gactagccag acacacattc cccScccggt
ggtggaggtg gaacccaggg
|
58801ttttgcttct gccatcccct caagtagccc cagccccact
gccccgctca ccacggaagg
|
58861cattatggaa gttatcgatg accacaggca agtagccagc
ctccagcagc tccagcaccg
|
58921tgtggctgcc aatgtagcca gccccacctg ttaccagcac
cttctctgcc atggcacctg
|
58981gcccaggata cagagtctca gaggtggctg aggctgcctg
ctcagagctt ccttcccact
|
59041ggaatcctgc cccctaagct cgctttggaa ggaggcggca
gtgtgcccta ggtaccagac
|
59101tggctcagaa gtcagccctg gggcaagtct gggtaccatc
actttctggc cttaggcttt
|
59161ggaaattaat tagcctcttg gcctcagttt ctatctctgt
aaaacagagc taataattgt
|
59221ataaacttca tgaggcagcg tgagggttca gtgaggtgat
cttaagggcc cgccacagca
|
59281gagctgggga gacctgacac acaggcacct tattttctag
ttccacttgc cttggagttg
|
59341gaaaagatgg aatctgagga tccacacttc tttgtccaag
gtgactgagg actggagagt
|
59401cctgggcaga aggaaaatgg cagcacgatt gggactccag
ggtYgcagga aRgggttctg
|
59461tctgctcaga cccaggcttg tccaatgcct ccgccttcgc
taggtgtaaa ctggctcctg
|
59521ggcgcagtga ctaatacctc ctgctctagg cggcccccac
cccctttccc tcaagggtca
|
59581gctgggagga agcaggaaat agatcacatg gcctcaaggg
tgaggtcctt tgccaggcag
|
59641gctgaggcca gctcaggggc aaccacaccg tggttggtcc
tggagggggc cccaccccaa
|
59701cccccgctca gcctctgccc atgccagggc cagcccggtc
actcctggct caRagttagg
|
59761aatcccgccc aacttaggct actctgggtg ggccgtgtag
acgtggactt ggccaggtgc
|
59821gcacctccac cctgaacaaa ctctgcgggt agtacgggga
ggaagcccca gacactgagg
|
59881cctttcattc ccagcgaccg ggcccgctgc cgccttcctc
cacgctgcct ctatcccctt
|
59941ctgggctcac gcagctccaa cccacttgac caagagccct
ctgcgtgcca ggctccgtac
|
60001caggcacttt tgcatgattt tcctgaattc ccccagcatc
tcggtgagac aggtgttatc
|
60061actggcactt tacagataca gatactaggg ccagagaggt
gaaacagttg cccttcggtc
|
60121ccacagctgg cgacagcggg ctggaatctg gatcgccagg
ctcgcagccc ggccctctcc
|
60181ccaggcggct cgcccttccc ccaccgctgc ccgctggact
ctgcccgccg cgccgaagcc
|
60241gcccccgccc ccgccccgcg cctggcgcgg accccgaaag
tggtcgcaga gaggccctgg
|
60301gaagcacgaa agctggtctg aggccggctg cgcccccgac
agcggagtga ccttgctcag
|
60361ccgtcgccca ctcggttttc ccagtctgtc tgttggaggg
aaggggagct aggccgtggg
|
60421catacgaggg cggctgggtc tcaggctggg ctttgggctg
tagcgcggag cggggccgag
|
60481ctaggagtcc tcaggccggc aatgaatgaa ccccggccgc
cccagcccgg gcagcgggga
|
60541actgggacaa agggggcggg cctgccctgg agggacgctg
ccaggaacac gacccgcccc
|
60601tcggaaactc cctcgctccc cgcggactcc ccggcccctc
gcgagcccac ccggcccttc
|
60661attccgtctc ccgaacctgc tcgggttccc gcgccccacg
cttgctgcag aggcaccgcc
|
60721tcctacgccc gagccgcggg ccctttaagt gctgacggcc
cactcMggcc ccgaccccgc
|
60781ccctccacgc ccccaaggaa acatgtcact cgggttacgg
ccactacggg gagggcggga
|
60841ggacaaaagg cctccgcgct gtgacgaaga ctgcgcagcg
cgcgcccgcg gaaggcggaa
|
60901gtgggcggtg ccaccccgcg agaggcgccg ccggcgccag
gtcccagtag cgggtgggtc
|
60961cttgccggtg ccccgggtcc ccgcgctagc tcgtcccaac
ccctggaaga gggctgcgct
|
61021tccgaggggg cagggggcag agggtagggg gcccacgcct
ccgccccact ctgacccgca
|
61081ggttttcaga cttgccggtg tgtgccaaac catgaattca
aaatcttgaa ctacScgatc
|
61141ccacgggact aaggcaggag ggggtcgcag ggggcctggt
gctggaagtc cagtttgcaa
|
61201ataaaccaag gagctggagg aagctgtcag gccacactag
cggttccagc gctcttggct
|
61261ctcagccccc acctgccggg aagggtcggt ctgcactctg
ccttccacga cggcaggtta
|
61321gaaaatgatt gtttgtttMc aatgaaaagt agtagagcta
gagaataata tgcacaaaat
|
61381gtgacatcct gcgtgatgaa accagagcaa aggagcccta
aatgcaggag cgcacaggtg
|
61441tccgcgcagc cgggaatcag ccagcgcctg cccgcagagt
ccagggaacc gacaggtgag
|
61501cgctcccggg cccgggagcg ccagggagag gccgggccac
cgaggcccaa agcagcaagt
|
61561gtgtcctcag gggagcttgt gcaatagccc cagtcacaga
ggcaaagctc agaaacaacc
|
61621ccgtcgggtg ttctggccag caactgccgc aagcagcctc
ctgagtaagc ccaaaaccac
|
61681tgatttccag tcactatgga tttggggctc aggtggggaa
acagggagga aatccaaaga
|
61741ttaataaact agttcatagt ctccattttc ctctcagagt
gcaacatggt aaagtatttt
|
61801actcccccac gcgcatgtat acacacagct gcacaaccga
atgctggaat tatgatgtgc
|
61861cattcaacct ttaattacat aagctgtttt caaaaatcac
attcagcgtg gagattttcc
|
61921aRagatgctg gagttggcag aYggccacca cgtagctYtc
cactttccac aaatggcctc
|
61981tgccagcttg ggaagaacct ccatgacctg tgtcctgaga
agtcagagag caagggcccc
|
62041acggccatgg cagggtggag ccgtgtaRag ggtggccagg
tggccagctc gcggattcca
|
62101tccagagagg agactcaagg atcatgctaa gtagggaacg
gggttcccac acgtcctcag
|
62161gcattcaact cctgggccag ggtccgtaac aaagggagac
ttcagccctc aaagcctctc
|
62221actcctcagg tctgggcagg aggtccttct gccaagcagc
tcctcctgcc cttcgcctgc
|
62281tttctgccag gagagacctc tgtgtagagc tggctatgag
gtacctgcac catttaacct
|
62341attctcattt ccatgtcccc atccatgaat catctgtgtg
tgcccctatt tccacatcat
|
62401ccccagggct tcaggtgggc aaggggctca gagtttacag
gtagcctgag ccactttgga
|
62461gctagttttt ctgttcaggg cttgacagat aaagtttcca
gcttccagaa gcttctggag
|
62521attcacaccc tttgagaaac aagttagagg atgcggtaag
tcatggtatg ccctcaacac
|
62581cagggaaaac atcagcatgg Rcagacaact gtgatactga
aaagtaaagg tgaagataaa
|
62641caggcttttt ccttgacagc Rgggcaccag ctgcctgtga
gctcctgtct gtctggcacc
|
62701tgggttattc ctctgactcc ccctcatgta agatgcccaa
tctctgtcat ggtttgtagt
|
62761gccactacca gggcacagat cttatcagtc ttgttcagta
ctccctcttc agggcccagc
|
62821acagggcctg gcccacagag gtaaaaaact gatattcaag
tgacaattgt gaggcagaga
|
62881gKgagggata aaaacaccaa ctgaaagggc cagacagaaa
ccctctgttc atacagtagc
|
62941tcatatttgc tgaagtgcac tctgtgctca gctctgtgat
aagcattcta cataactttt
|
63001ctttcttttt ttttttggag acagagtttg ctcttgtcgc
ccaggctgga gtgcaatggc
|
63061acgctctcag ctcactgcaa cctctgcctc ccgggttcaa
gtgattctcc tgcctcagcc
|
63121tcccgagtag ctggggttac aggtgtgtgc caccacaccc
agctaatttt tcttttcttt
|
63181tttttgagag ggagtctcac tgtgtcgcca ggctggagta
cagtggcgtg atcttggctc
|
63241actgcaacct ctgactcctg ggttcaagca attctcctgc
ctcagtctcc cgagtagctg
|
63301ggattacagg tgcgtgccac cacacccagc taatttttgt
atttttagta gagatggggt
|
63361ttcaccatgt cggccaagct ggtctcgaac tcctgacctc
aggtgatctg cccaccctgg
|
63421cctcccaaag tgctgggatt acgggcgtga gccaccgtgc
ccagcaattt ttctattgtt
|
63481agtggagaca gtgtttcacc atattggcca ggctggtctc
aaactcttga cctcaggtga
|
63541tccacccgcc ttggcttccc aaagtgctgg gattacaggc
gtgcgcctgg ccctctacgt
|
63601acgttttctt acttaatcct cacaatggct ccatgagatg
gatggcatta ttattcccat
|
63661ttcttaggtt cagagagatg aaataatttg tctgaggtct
catagcctgg gagtggcagg
|
63721agtaggcttt aaacccagtt ccatctgatc tttaagcaca
gatgctattc tgcttccgtc
|
63781ccgccactga gggccctggt ggactctggc ggatccctgg
tgagctgtct aacgctactg
|
63841tcctcatttt acagagaaca aaacaaagcc aagagagaac
tgactcattt caggtcatga
|
63901acctgaccct tcccagggcc ccttccatgt tcctggtgtc
tcctaggaMt gaactgtcaa
|
63961agtcaccctg acactccagc cttcttatgc ccatgcgtgt
ggcctcactc aaccctactc
|
64021tcacaaacat taaaatatta gatcaaatat ccataatccc
caacaccctt cccctctttt
|
64081gttttgtttt gaagagatag ggtcttgctg tttcacccag
gctggagtac actggcagga
|
64141tcatagctca ctgcagcctc aaactcctgg gctcaagtga
ccctcctgcc tcagcctccc
|
64201aaagtgctga gattacaggc atgagccact gcgcctggct
aaccctttcc ctctttactc
|
64261ctcagcacct taacaacccc aaataccccc atccactttt
gttctcagct tcaggccccc
|
64321tggtcagttc ggggctgtcg ccaccagggg gtgggtgggc
ttaccgtgtg aatgcccaag
|
64381ccctctagca tgtagaccag gtcttctgtg gccaagtttc
ctgatgcccc ctgtgcgtag
|
64441ggacagcctc caagtcctgc cacagaagag tccacgacac
tcactcccat ctagaaacat
|
64501aaggatggtg aaacacagtt gttgctgggg acaagaggcc
acagagatga gccttgcaaa
|
64561cctcccaatc gtctgttgcc tgaaattcta gagtcattct
ttgctttggc ttatgattct
|
64621gttgacatga caatcccaca gaaagagaca gtgcttctcc
ttttagtttc tgttaaactg
|
64681tttcctctgc cagcagtatc tttcctttca tggtgaactc
tcattcttta gNttccagtc
|
64741tgaaagccac ctgctcaggg agaccttttc tgatcaccag
cctaaccccc tcccactgct
|
64801gagatttcag acccctgttg tttactgtga ttcatttatt
accccccccc cacttacccc
|
64861ccaccacctc caggctactc tcactcagtc agggccttgc
cacacgaggg ccacatccca
|
64921tcttcccagg tcagtcacct cccactatcc caaatgacta
tttcactttc tcctctcttc
|
64981ttaaacctct atcaccccct tccccatcct cattctcatc
tgctgcttta tggaaatgga
|
65041tgcaatcaag agatgtctcc attgattccc accatcacat
ctacccacct gcctacatct
|
65101gggcctacag acccactgtc cctcatgctg cctgagatgg
acccYgagct cctagccaag
|
65161gccaacccct ccaccttggc gtgaggccca ttcccacctg
cttcaggatg tgctccagta
|
65221agtctctccc tctctgctgc aacctgttac tcccctccac
tgggtcatct tcacacagcc
|
65281tgcgatctct cccatctttt acaaaccttt ttggaaccct
ctaacctcca atttctttcc
|
65341ccccattcaa agcaaagtcc ctcaaaagag ctgttcccat
ttaacatcta ccattctcat
|
65401ttgaacccat tcgaaacagg tttgcgtccc cacaactcct
ccactgaaac agctctagtc
|
65461aaggccactg gtggcctcca tgtagctaag tacaaaggtc
aagtctcttc atctttgcac
|
65521ttgactagcc gcatcatctt ggacaccttc tccatgtggc
ttccagggct ccacatccct
|
65581tggttttcct cctagtgctc tagcctctcc tgaggcctcg
atccagtctt tgctggctct
|
65641tcctcacctc cctgatctcg gttggagccc ttactgctca
ttcctcagac agcttctcta
|
65701tctccactca ctcccagtta actgcaccca ggttaacaca
cctgcctata gatgtctcga
|
65761gcttcacaga tcagaacacR aactgctgag atccggtcac
gcacctctgc cctccaggcc
|
65821tccttgccat gtctctcacc tggattgctg taggctccaa
actggttctt ctctctacag
|
65881tgtattctct acacagcacc cagaggagcc tctttttttt
ttttgataag aagtctcact
|
65941ctgttgccta ggctggagtg cactggcgcc atctcagctc
actgcaaatc actgcaacct
|
66001ccacctcccg ggctcaagtg attctcatgc ctcagcctcg
caaatagctg ggattacagg
|
66061ctcacgccac cacgcccagc taatttttat atttttagtt
gagacagggt ttcaccatgt
|
66121tggccaggct ggtctcaaaa ctcctgacct caagtgatcc
acctgcctca gcctcccaaa
|
66181gtgctgggat tacaggtgtg agccactgtg cccagccgag
gagcctctca aacggaacat
|
66241ttcagatcat ctccctcccY gcccctgctc aagactctct
gttagcttcc cagctcagtc
|
66301tgaaagagtc aaagtcctac aaggcccccg atctggcctt
cctctaaccc tgacatctct
|
66361gcccccctct cctcagtcac actgctcccg ccacatgcct
cctcctgatc cctgaacaca
|
66421gcaagcacac tcctccctca gggctctgcg cctgctttcc
tgggtggggc tcccttccct
|
66481ccccctccct gctagggatc cgcagggctc actccctcgc
ttccctcagg tctctctcaa
|
66541atgctacctt ctgagtgagg ccactctaca gaaaggcctg
gcactgcctt aacctgcttc
|
66601attttttctc cacagtgttt atgaacacct ggcctgctgt
atgtttgttt atttattatc
|
66661tgtctcatag tactagagtg tcagcctcat gagggcagag
actctgtttt ggtcacagct
|
66721gaatccttaa tgctgagaac agtgcctagc acactaggca
ccgttaggtt aggttttaat
|
66781aggtgaataa atggtcttac aatgtgctat ttacacgcct
gtaatcttcc atctgtcttc
|
66841cccacccacc ataacatgag ctcccagagg gcagggattg
ggtcttgtta ccattgtcta
|
66901agtcagcact taacctggca catcgatcca tatttccgaa
gtaactgatg gaagagggag
|
66961gtcagaggaa gctactgcca gacgtcacac agctcaacct
gttccctgat aaattttcaa
|
67021aaaggggatt ctgagatatc actgccatga aacagagaag
cacagaggag caggagtgtc
|
67081ctgagcRtga tcaggatgaa gttttgcctc agactcacct
cagctgtgca gaattcccct
|
67141ttacctgcct ggcaaggcat aggagaggaa gtcactcttc
ctgtctgcct ggctgggaaa
|
67201cgcatgagct gaaggaaagc ccaggaacca gggcagggta
tcacagtaag ctgaaaaatg
|
67261aggagaccac agaactacga accttaacct tgacagccac
aactctgagg aaaccgaccc
|
67321agaacataac agactcacct ggcttagaca cgaacctcta
ggggataatt gagaggaaaa
|
67381aaaaagtggc tggaactgcc atcactatcc tagagatgga
aggttaggcc aatgctacag
|
67441caaggtagct gtggtcagac actaagaatg ctccttctat
ctggctgcca gccaatggat
|
67501ctccattctg gaccagocca cgagaagcaa acctcaaagg
aaactaatct gaggtcttag
|
67561ctcaatctgt ggggaacggc attaaagcct ctccctctga
gtgacctctg ctagcttctc
|
67621tacctcctgc ttcctcatct gcttctgcta cacacccgca
cactgaaaac cctgtatatt
|
67681gtatgagtcc tccctgaacc ccacatcagt cctgaggtgc
aattctgcct agtcatcttt
|
67741cctcttccct caacagcagc ttactttatg ttcttcaagc
ttcactgagg cctcttttgc
|
67801aaatcctccc agatctcctc agctgggatg gggcccctct
aggcttcctg agccccatgc
|
67861ttcctccctt catggcatct gtcataatgc agtgggattg
ccatgtaact cccttgactg
|
67921tctccccaac acagagYtgt acacttcaca tctgggcagg
gtcaccatga ctgtgtccac
|
67981cattgccagc ttggaacctg gcatactggc atcagtaaat
gtttgctgaa agaataaatg
|
68041ataacaagct gtcctgccca ccgtgacctt tgggagaatg
ggcatatgct tttgattacc
|
68101tgcagggcca tcaaggtgtt ggccagggct tgaccatagg
tgtcatggca gtggacagcc
|
68161agggcagcca gaggcacttc ctgcatgaca gcagaYagca
tgtctttcat gatccctggg
|
68221gtgcccacac caatggtgtc ccccagggag atctcgtagc
agcccattga gtagaacttc
|
68281ttggtgacct aaggaagcaa gcaggcactt ggaggataca
gaatccacca gccaggggat
|
68341ccatgcactc agaagagggg gcctttgcct gggcagaaca
cttctgggta tgacgcactc
|
68401agttcctact ggattacatg ctcctcacca ctccaactgg
gaatgatgat cctcaatcta
|
68461tgatcaggag actgaggcgt aaggggcaga gccagccgct
ggagccagcc cacagtcctg
|
68521aagctccaac ccccgtgctt tcctccctac ctgtgcccct
cagacttcag tctcacttac
|
68581ggctgtcaca tcatactgtc agacccaggt gctggaatca
gtgaagttga ttccttccat
|
68641gtcgttttat cctcagcaat aaaatccatg aaatcatggg
tctgagatgc tagttatatt
|
68701ttttttcttt tttttttttt ttttttgaga ccgggtctca
ctctgtcatt cggctagagt
|
68761gcagtgKtgt gatctcggct tactgcaacc ttggcctctc
agactcaagc aatcctccca
|
68821cctcagcctc ccaagtagct tggaccatat gtataaaaat
gtatatattt tacatatata
|
68881tattttttga gacagagtct cactctgtcg cccaggctgg
agtgcagtgg cacaatctcg
|
68941gctcactgca agctctgcct cctgggttca agtgattctc
ctgtctcagt ctcccaagta
|
69001gctgggatca taggcaccta ccaccacgcc ccactatttt
ttgtattttt agtagagacg
|
69061gagtttcacc atgttggcca ggctggtctt gaactcctga
cctcaggtga tccacatgct
|
69121tcggcctccc gaagtgctgg gattacagtc atgagccacc
atacccggcc aatcaatagt
|
69181ccatatatat atatatatat atattttttt tttttttttt
ttagatggag tctccctctg
|
69241ttgcccaggc tggagtgcgg tggcgcaatc tcagctcact
gcaagctccg cctcccgggt
|
69301tcacgccatt ctcctttctc agcctcccga gtagctggga
ctaccggcgc ocaccaccac
|
69361ccccggctaa ttttttgtat ttttagtaga gacggggttg
caccatgtta gccaggatgg
|
69421tctcgatctc ctgaccttgt gatctgccca tctcagcctc
ccaaagtgct gggattacag
|
69481gYgtgagcca ccgtgcccgg ccaatagtta tattttttaa
tagaggtaca tcactattta
|
69541aatttttgga agcccatttg cacatctcta aaaccactgc
aaaatgggtc catattggaa
|
69601taggtccaat atgggtccaa ttggaataag ccatactgga
atagggtggg cccctaatcc
|
69661catacgactg gtgaacttaa aaaaagatgg cctcacccaa
ggagctgctg cccacacggg
|
69721gctgctggac aaggtgcaga gggatgtggc agggaaaggg
gaccagaaga caccagtgat
|
69781ctgctaaata aatgaaatgg tgacgtcgct tccccagtgg
ccctgcagag tgtggggcgg
|
69841cagtggctgg cctttagggg gcagcagggt gcaggggaag
gagcaggcct ttgaagtcac
|
69901gagatgctgg gttaaagtcc tagttctgct gttcactagc
tgtgggcctt ggcaagcaac
|
69961ttcacttttc tgagcttcaa tttctgcttc tgaaaaatgg
tgatgaccct ttggtcataY
|
70021ggcaaggatt gtggcaactg aggctaagac ctggagcagg
gcagctgctc tcaagaaaca
|
70081gttgctactg ttaccattcc acctatctgg atgccacaaa
gtatcctggg aagaagtggg
|
70141ctttggagag agaaaaaatg gggtttgata cctgatttca
ccatttgtaa cctgtgtggc
|
70201aagttattta gtgtcagttt tctcaactgt aaaagggaat
aataatacca aatttgcaca
|
70261gtggttttga ggactaaatg acataagttc ttgggctggt
caaactcaat tcccatgcca
|
70321tgttcttctc agtgttgacc tggtgactgt tcagaggaca
tcagggttgt ggcctttcaa
|
70381tcactacaag gaactatggg aactcctggg taaggagccc
ctcctcagag aatcacctca
|
70441acgaccagac tggaaactga attggaggtt ttcaggctgg
atagaggcca ggggcttcaa
|
70501ggactacatg ttcggctagg aggggggcct ctagggagca
agtgcagggc tgtgctcaca
|
70561gcaggagctt aatgaaggag ctgggtgaat gaatgaagtc
aggaacctgc cagaaagggt
|
70621ggggagagga acctatgcgc tcaggggcag acaaggtggc
caaccctcac caaacccccc
|
70681gccctgacac atgcacacac ctcagctact ttagctgggg
agatcttccc ttcataaggg
|
70741cagccaagag cacaggagac gtacctgtgg gaagacaggg
gaggaatgag gtcagtgtcc
|
70801tgagcttttt ggctagcaga actgaggcag ggctgtttaa
cacacatttc tgatcagtgt
|
70861gcaatcaaca cctgcagctg ggcggagtaa gggcagggat
ggtacaattc agtgccagga
|
70921ggaggcagta gagagcaatg gcagggaact gggggacaat
ggacctacaa ttgaggaagc
|
70981agaagttgca caggcctcag gagaggcagc caaggattta
caataagcgg aggaggagct
|
71041agagagggca aggagagtaa gcagctgggt tgtaaggtgg
ggagatggag caaaactacg
|
71101tgccagagga gctggggcca gtactccaaa aggagaccaa
agactgggta aaaccaaact
|
71161cagaacaaga gctgagttgg atatgagtca gtaacaggct
gggctggcct gaggaccaag
|
71221ggatgagctg ccccagtgag atgctagagg attcattcat
tcatttattc acctgatgtt
|
71281tactgagttg cctgctatgt gccaggcact ggcacagagc
agtgggcaag actgataagg
|
71341ttcctgccct ctcagagctt atctcaagtt agggagatgg
ccaataaaaa agcaaccaag
|
71401taagtaatgg agaaaatctc agaagtgatg tgccacagag
gaaagatggg aaatgatagg
|
71461aacaagtgga ggaggccaac tagtgagggt ccaggaaaga
tccctctgag gacaggatgc
|
71521tggagccgag aggagccggg ggtggtctgt gagaagagca
ttccaggcag agggaagacc
|
71581tgggcaaagc cctgagacag aagagccagg catgctccag
acagaacaaa ggacagctga
|
71641ggcagacaga gcaaggggaa aggaagtatg agatgaggag
gtcagcaagg tgggcacagg
|
71701tctgatcatg ggtcttaggg ctatggtaag gagggtggat
ttgggatgta ggtgacttct
|
71761attcccacct gcccttttgg gagctgtctt taaaaccctt
tagagtcaag caaattctgc
|
71821atattaagag gcataataaa tgttcaacag ataaataatt
tcagactcaa agatctcagt
|
71881gtacttttcc attttgatgc tcccacttat tctcdaacca
ctgctgagca agaaaaaggt
|
71941aagagagatg cttagaaaga cacagatctg ggagttgggc
caatgttact ggagcacctg
|
72001cttccccatt catccacctg cccgtcagtg actgagtgcc
cactgtggct aggccccaag
|
72061ctgggagagt ggagcacccc agggactggg agagatgtgg
gctttgccct catggagtgc
|
72121acggtctagt ggggtggggc agggagggaa tttaacaagc
agctaagtgc tacatttaga
|
72181ggatgtcccg acaccatggg gtcccagaga agggcactaa
ctccagctga aggactggag
|
72241cagcttctca gaggaactga ctcccacaag aagacctgaa
ggatgagcag gagttatccc
|
72301cgagaagcat gatgtggagg aagtgttctt tattttttgg
agacagagtc ttactctttc
|
72361acccatgctg gtgtgcagtg gcatgatttt ggctcacttc
agcttggacc tcccaggctc
|
72421aggtgatctt cccaccttag cctcctgagt agctgggact
acaggcacat gcaaccacac
|
72481ctggcttttt ttttgtagag ctggggtttc accatgttgc
ccaggcccaa gccagtcaca
|
72541aactcctggg ctgaagcaac ctgcccacct tggcctccca
aggaaggttg ttctgagtct
|
72601agagagagca cgtgcaaagg cccagaggca agagtggagg
catgtgacaa acagaaagaa
|
72661gttccagttg ggctggagtg taccatgaag aggaagcagg
ggccagaagg gaacttgaac
|
72721ggtacggcta cagaaaagag ccgggaccaa atcatgcaRg
gtttgtaaac ctcattaaaa
|
72781agtctgcact tgattagtca ctgaaagctt tttaaccagg
agggatgtga tcagatgtgc
|
72841acttttgtgg ggtttttttg gtttttgttt ttgagacaga
gtctcactct gtcacctagg
|
72901ctggagtgca Stggcgtgat cttggctcac tgcaacctct
gcctcctggg ttcaagtgat
|
72961tctcccgcct cagcctcctg agtagctggg attacaggtg
catgccacta cgcccggcta
|
73021atttttgtat ttttagtaga gatggggttt ccccatgttg
gccaggctgg tttcaaactc
|
73081cttacctcag gtgatctgcc cgcctcggcc tcccaaagtg
ctgggattac aggcatgagc
|
73141caccatgttc agcccagatg tgcacttttc aacgatcatt
ctggctgcaa tgtttttttt
|
73201tttttttttt tttttttgag atggagtttt gctctgtcac
ccaggccgga gtacagtggt
|
73261gtgatctcgg ctcaccacaa cctccgcctc ccagattcaa
gtgattctcc tgcctcagcc
|
73321tcccaagtag Mtggaattac agctaatttt tgtattttta
gtaaagacgg ggtttctatc
|
73381cactaccacg cccagctaat ttttgtattt ttagtagaga
tggggtttca ccatgtcggc
|
73441caggctggtc ttgaactctt gacctcaggt gatccacctg
ccttgtcctc ccaaagtgct
|
73501gggattacag gtgtgagcca ccatgcccgg cctctggctg
caatttgcac agcagtgtga
|
73561ccttacagta gagtattcgc ccttcctggg cctcggtttt
gtaatttata aagtgaggat
|
73621aacctactcc ctgctgggct attgtgaggt ttcaattatt
atagataata cacacacaat
|
73681gcctggaacc actgatatta gagatgtgat gttggaaaca
tagaagccta ggtaattctc
|
73741cagggatgtg tgaagagcta gtgataaagc caggactcaa
ctgacctcca caaacccgtt
|
73801agtgtcctgt cctgctagat tcctttagca tgatagcagt
ggtgctatca tggctcactg
|
73861cagcctcaaa ctcctggtct caagccatcc tctgcctcag
tctcccaagt tgctaggact
|
73921acaggcgcat gctatcatgg ctagctggta aactgaccca
aaattcaggt ttgagagaaa
|
73981gtacttccta ggatttcttc tgaccacact tatttgggaa
aagatgtcta ggtgtggagc
|
74041tcaggctgcc cccacccagg ataagaagtt tgtggcagga
ggaccacttg agtcagagtc
|
74101tagccccatt ccagaacggt acagaggaaa ggataccaat
gtgctctgac tcacccccgc
|
74161acagaaatat tggctgactg cgctgccttc aggattgcgt
caaacctctg aaaactctcc
|
74221tctatggaac aattgatgtt cttcttggtR aagagctctg
aggcagctcc aaagatgact
|
74281acttccttgg ctccagcagc aacctgccaa catccaggtg
aactcctttc agcacttttc
|
74341tctttttttg tttgagatgg agtcttgctt tgttgcccag
gctggagtgc agtggcatga
|
74401tctcggctca ctgcaacctc cacctcctgg gttcaagcga
ttctcctgcc tcagcctcct
|
74461gagtagctgg gattacagga gcccaYcacc acgcccggct
aatttttgta tttttagtag
|
74521agacagcgtt tcaccatgtt ggtcaggctg gtttcgaact
cctgaccttg tgatccaccc
|
74581acctcagcct cccaaagtgc tgagattaca ggtgtcagcc
atcatgcccg gccagcactt
|
74641ttctctttaa agaacactga cacagagtag caaaaaattt
ctcttaaggt aaattttatg
|
74701ttatgtgaat gttatgggtt gaattgtgtc ctcctaaaaa
tatatgttga aggattaaaa
|
74761cccagcacct cagaatgtga ccttatttgg aaacagcgtc
attgcagata tcattagtta
|
74821agatgaagcc atactggaat agggtgggcc cctaatccca
tacgactggt gaccttaaaa
|
74881aaagatggcc agccgggcgc agtggctcac gcttgtaatc
Wcagcacttt gggaggccga
|
74941ggcgggcaga tcatgaggtc aggagatcga gaccatcctg
gctaacacag tgaaacccca
|
75001tctctactaa aaatacaaaa aattagccgg tcgtggtggc
acacgcctgt agtcccagct
|
75061actcRggagg ctgaggYRgg agaatcactt gaaccYggga
ggtggagStt gcagtgagcc
|
75121Ragatcatgc cactgYactc cagcctgggY gacagagcaa
gactctgtct aaaaaaaaca
|
75181aaaacaaaag atggccaagt gaagacacag agacacagaa
aaggtggccc tgggaaaacg
|
75241gaggcaaaga ctggagagat gcatctacaa gccaggcaat
gccaaggact gctggccacc
|
75301accagacccc agcagagagg cataggacag attctcccag
aggcctcaga aggaaccaat
|
75361cctgctgaca ccttgatttg ggacttctgg cctccagact
gtgagagaat aaatttctgt
|
75421tgtttttaag ccacccaatt tgtagtgctt tctttttttt
tttctttttt ctttttttga
|
75481gacaaagtct tgctctgtca cccaggctgg aatgcagtgg
catgatcttg gctcactgca
|
75541acctccgcct tccgggttca agtgattctc ctgcctcagc
ctcctgagta gctRggatta
|
75601caggtacctg ccaccaagcc tggctaattt tttgtatttt
tagtagagac ggggtttcat
|
75661cgtgttagcc aggatggtct cgatctcctg acctcatgat
ccgcccgccc tggtctccca
|
75721aagtgctagg attacaggcg tgagccaccg cgcccggcct
gtagtgcttt cttacagtag
|
75781cactaggaaa caaacacagt aatttctctt aattaaaaaa
aaaaaaactt tgattttccc
|
75841caaggaaacc accaccactg ccatcaccac cctggaagtc
actcttgaga aaaagctttt
|
75901ttttttttct tgctgtgtca cccaggctgg aagagtgcag
cggtattatc atggctcact
|
75961gcagcctcga actcctagtc tcaagccatc ctgtgcctca
gtctcccgag tagctaggac
|
76021tacaggtgca tgccatcaca gccagctaat tgattttttt
tttttttttt gtagagacaa
|
76081ggtctcctta tgttgctcag gctggtctca agcttctggc
ctcaagctgt tctccggcct
|
76141cagcctccca aagtgctggg attataggtg tgagccactg
tgcccagcca aaaaaaggtt
|
76201tttgcctaaa tacagaacca acgcctccaa agatgttctt
gtctaaaatt gtaagaaagt
|
76261tggcagatgc cagcaactac tgttgaaact cttgtggaga
gtttggttac atttctctaa
|
76321agaagtggat aatcaaaaga gctaacattt attaagcagt
taccttttat ctggctcttg
|
76381ctaagcaatg tacatgcatc ctatcttctg aaatgctcac
aacttcaggt actatcattt
|
76441agccctattt tataggcttg tcaacttgtc aagatcacag
agcagtgagt ggcagggcca
|
76501ggtttgcccc agggtctggc tgacagacaa gctattcaga
tggacatccc aggacagggg
|
76561actgaggcgc caagacaagg cagggaccaa tgccatcaat
ctcatttcag gagcccccac
|
76621caacaagcta tcctcttacc gctgcctcga agcctttcaa
atttggggtc aggactgggt
|
76681agttgatgcc aggaaacttc tgaatgccct tcaagacttc
agtgtggtca cccatctagg
|
76741aaccaaggga gacattgcca agtcatcacc aagagcagac
agagagttca gttagagaaa
|
76801accttttcat cacaaaacct ctgttctcca gaactcttag
cgagtaattc cttctgcaga
|
76861gctgagtctc tccaatactt ttactgtttg tttgactgct
gatggctcag aagggccctt
|
76921ggtttggctg agatcccaat ttctccatat ggcccatact
gccagcttta catatgcaga
|
76981aacagcagga atactactac cagccattta ttgagaatgt
actctgggcc aggcactgag
|
77041ctcagctctg tgttaagcac tcctttgtaa caggatgttt
cttcttcact taactatctt
|
77101tgtgaagcag gagttgtcaK tcttcctctt ttacaaacaa
agaaaccaca gacaggcata
|
77161gagggtttta gactttaggg ctagaagagg tcatctctaa
cactgaggag gggaaggcct
|
77221tagcaatgtc actgagcaag tcagagcaga gccaagactg
aacccaaggc cctgaatcct
|
77281gggtcatgtt cttttgctgc aacacagtgc tatgaatcac
ctgagacctc tcaaagccag
|
77341gggcttggaa acctatgttc tcaacttcta cttgcttcaa
aggcaaatgc aaaacttttc
|
77401atccctRgag aaaggccttt cattgagggc tagggctcac
ctggggaacc cacttaggag
|
77461acacaaagct ggtggtttct ataacagaga gtcctgcttc
agaaagcatg tctatcagct
|
77521tgattttcac tggagtagat acgatattct atagtggaga
gagaaacacc aaggcagcaa
|
77581agttagtaac aaaacagcct caaaatgcag tacctgttag
ttcaagtact atagataatt
|
77641ttttgcagtg gatgcagctt ctcacctgaa aaggagttat
ttacatagaa acattattct
|
77701gccatgcagg ctttcccgta agtaaatgtg tgttaattta
taatcccatc ataaacaaac
|
77761tgagagcaat gtgtgatggc ctgaaagggc agagatgact
aaccctctgg ggagtatggg
|
77821atggggcccc caaagtatca caccctcctc gcttctgtct
cccaattggc ataggacttc
|
77881agcctcatgt gttcagcgta tagcttcttt atcttcctcc
ccaccatgtc cagtagctca
|
77941acagattcca tggattcctc tttccaaatc taccatcatt
atcctgtata taacatggca
|
78001tagtctcaag ccactaattc atcttacaca ggaatcctcc
taaaatgcag cttccaacct
|
78061tccattctct tgcatcaaaa gctttctatg gctccctaat
atttacagga ttacgcaaaa
|
78121aattctaaga actccaggtc caggcggaca cattggctca
cgcctgtaat cccagcactt
|
78181tgggaggctg agacaggcag atcatttaag cttaggagtt
tgagaccagc ctgggcaaca
|
78241tggcgaaacc ccctctctac aaaaaataca aaaattagcc
aggcgtggtg gcacgtgtct
|
78301gtgatccagc tactcaggag gctgaggtgg atcactggag
cctgggaagt cgaggctgca
|
78361gtgagcaatg attgtgccac tgcactgagt gacacagagc
aagaccctgt ctcaaacaaa
|
78421aagaacacac aaaaatactc caggtccttc tcgctaggtc
ctccccttgc ctgccttctc
|
78481cagtttctct cccactgctc taacttaatc tttccacaaa
aWtttttttt ttttgagatg
|
78541gagtctcact gtattgccca gagtggagtg cagtggcaca
atctcagctc actgcgacct
|
78601ccgccttccg ggttcaagcg attctcctgc ctcagcctcc
agagtagatg ggattWcaca
|
78661agcatgccac caccccagct catttatttt agtagagatg
gggtttcacc atgttggcca
|
78721ggctggtctc aaactcctga cctcaggtga tctgcctgcc
tcagcctccc aaagtgccag
|
78781tattacaggc atgagccatc atgcccagcc tgtcaaataa
tttttgaaag ccctccatgt
|
78841tgcaggcatt gtgctaggtg ccggggatat agcagtaagc
agaagcagaa cagacaggat
|
78901tYtgcccttc Rggaacttac acactattgt ttccaacaag
cactcactat taaagctagg
|
78961atggacgtgc taaaaaaaaa aaaaaaaaaa aaaaaaaaga
gaaaaagaaa aaagcttttc
|
79021ttattgaaaa aataatcaat atatgattct ttcagaaaaa
catgccaaaa acaaaagaaa
|
79081accaccctta gaatctccca gtgataacgc tattaacacc
ctggtgtgta actttctaga
|
79141tctgtgcagc ccaatatgtc actagtcaca tgtggttatt
taaatttaat aaaaattgta
|
79201taaaaataaa aatacaattc cttggccaca ctagtcacat
ctcaagttct caagggccac
|
79261atgggtatag tggccaccac atggaaaagc tcaggtccag
aatatttcca tcttcacaga
|
79321aagtgctggt ctaggtccta gtctagataa atgctcccat
acatatataa acttttttct
|
79381tacataaaag tgttaagatt aaaaaataca tggccaggcg
cattggctca tgcctgtaat
|
79441cccagcactt tgggaggctg aggcaggtgg atcacctgag
gtcgggagtt caagaccagc
|
79501ccggccaacc tggtgaaacc ccatctctac taaaaataca
aaaattagct gggcatggtg
|
79561gcaggggcct gtaatcctag ctattcggga ggctgaggca
ggagaatcac ttgaacccgg
|
79621gaggaggagg ttgaggtgag ccgagattgc gccattgcac
tccagcctgg gtgacagagt
|
79681gagatgccat ctcccaaaaa cacacacaca cacacgcgcg
cgtgcgtacg cgcacatgca
|
79741ctatttgttt ttgtttggag acagaatcgt gctctgcctc
agcctcctga agtgctggga
|
79801ttacaggcat gagccaccac catgcccagt cacatgtact
attttataaa ctgcttgagt
|
79861cactttatat atacctatgt tattaatggc ttcataatat
ttcattttat aaaaagtcca
|
79921tagtgtatct gacccaactt tcctcatact aaatatttaa
gttgtttcca actgttctgt
|
79981gcttaccaaa caggtttgta aggaacaccc ccaaggctaa
atctctacat ttggccttcg
|
80041tgacttgctt tggataaatc cccttacatg gaattgctgg
gtctacccca ccccactggg
|
80101ctgtggacct ggggacacca aacctgttgc accaccattc
agtttatata tatacatata
|
80161ttttttaata agatagagtc ttgctatatt gcccagactg
gtctcaaact cctgggctca
|
80221agccatcctc ccacctcagc ctcccaagta attagggatg
acaggcatga gccacccatc
|
80281cagcttgccc caccatttta gatcatttaa ctgtcacagg
tgtctgtccc tgtttggcct
|
80341cctctactct cccctaactt gtgcagagga atcacatctt
gcatagctct gtcaactgcc
|
80401attgcaccta tcacacgtaa tactcaaagc agatgcttga
aaaaactgtt tttttggctc
|
80461atttccaact ttaccttttc attttgtagt ccatctcggg
gaccaacttc cacaattttc
|
80521acccgctttg gtaaagtgcc catagatgag gtgctgacct
ttggtttaaa agaggaaaca
|
80581aaaagtatga ggaagagatt gccacaattc ccagggagac
caatatgaaa gaatggatct
|
80641atcttcacta ataatgagac aagaagaaat atttctcacc
atttaattca catttggtct
|
80701attttagaat taagaacaaa aagaatattt cacttagtaa
caggaacaag caagagattc
|
80761atccttccag taccggttct cccctgaagt ccagactcct
tttccactgc ctacctgaca
|
80821gctctattcg catctcttca tatagcagtc ccgaaacaga
actctaattt ctcctaaagc
|
80881ccatctgact ccatcctttc catctctgtc aaaggcatcg
catgtaccct actgcataag
|
80941ccagaacttc attgagccat ttcacctatt caccatggcc
tataggactc tgtatgctgc
|
81001tgtatgtatg ttagaagtag tttaaaaagg ccaggtattg
cggggggcag tggctcatgc
|
81061ctgtaatccc agtactttgg gaggccgaag cgggcgatca
cttgaggtcg ggagtttgag
|
81121accagcctga ccaacatggt gaaaccccat ctctactaaa
aatacacaaa aaatagccgg
|
81181gtgtggtggt gcacgcctgt aactccagct actcaagagg
ctgaggcagg agaattgctt
|
81241gaaccaggga ggtggaagtt gcaatgagcc aagatcgtgc
cactgtactc caccttgggc
|
81301gacaSaggaa gactccattt ccaaaaaaaa taaaaaaagg
ccaggcacgg tggctcatgc
|
81361ctgtaatccc agcactttgg gaggccaagg caggcagatc
acttgaggcc agaggttcga
|
81421gatcagcctg gccaacatga tgaagaaacc ccgtctctac
taaaaataga aaaattagcc
|
81481aggtgtggtg gaatggacat gtagtcccag ctactcaaga
ggctgaggtg ggagaatcgc
|
81541ttgagcccag aaggttgagc ctgcagtgag ctatgactgt
gccactacac tccagcctgg
|
81601gcaacagagc gagaccctgt ctcaaaaaaa aaaattaaat
gactctatat gtcacttgat
|
81661gctttccaat taagaaaaga aaagactgta tgagttgcct
cctctgacct cctggaWtca
|
81721tcactcgccc ctacYgtcca ctcccaacct ccacccaaca
ggttgctaag ctccctgcct
|
81781tctcttccct ctgccccagg gttcctcatc tggctttttt
taaaaaaact ggctgttctY
|
81841acatctctct ctcatctttc agttgcagag aggcttcctc
tgaccaccct ttgcaaagct
|
81901gccattcctc ccacccccat tattttcgct attgcagagc
tataattatt tccttcaaag
|
81961cacgataaag aatgcctact caatgtctct tccagtagaa
cataagctct ttgagggacc
|
82021ttgtctgtct caactccact tcatccctag tgtttggcac
cgtgtttggt acaaagtagc
|
82081cactctttaa agttattaaa ataacacata aaccatgaag
gacacagctg tcccagaaga
|
82141gagcaattac tgagtgtggg gaggagtagt cagtcctgga
cttttcgggg tatgggcgag
|
82201atgcaggagg gctctcttct gttacagtca taggctgggt
gatgacaagc atgggtctaa
|
82261ggggaggtga cacccccagt agctgaagac agtttttaca
aaatgccctg agtctcctct
|
82321atataaagtc agctcaaaat cttagtcttc cctatcaagt
aacacaatac tttttttttc
|
82381ctctttcctc tacctgtctt gatactgtaa cttttcaaat
caactttgtt ttacagattt
|
82441aatctggata aatatactac aacgaggcaa agcggaaggc
acactgtgtg atccgctaag
|
82501gatctcaacc Ycctgaagtc ccccaggaat tccctgctag
gaagcagctg gaacatgtac
|
82561aactcacctg actggccttg ttttagccaa caagctttct
tagagactaa ggcgatgagc
|
82621cattgaattt catgacgtca acaggctaag ttggaaggtc
cctgcaactt gaatctccct
|
82681ccaacaggga tgttcagcct ctgctagtat atcaccctaa
aactatctca ctggaacata
|
82741agtttcatga gacagggact ttgttttatt caatgctgta
tttctaaggM cctgggacat
|
82801aataggggct cgataaataa cagttgagtg ttgctgaaat
aatctaaaac ctgcttcagg
|
82861ccaagcgtgg tggctcacgc ctgtaatccc agcactttgg
gaggccgagg tgggcagatc
|
82921acctgaggtc agaagttcga gaccagccta gccaacatgg
tgaagcccta tctctactaa
|
82981aaacacataa attagctagg catggcagca ggtgcctgca
atcccagcta ctcgggaggc
|
83041tgaggcagga gaattgcttg aacccaggag gaggaggttg
cagtgagctg agatcgtgcc
|
83101attgtactcc agcctggggt acaagagcga gacttcttca
tctcaaaaaa aaaaaaaaaa
|
83161aaaaaagctt ctaaaacctg cttccaagct gcttttatta
gaacattata aactcaattc
|
83221cacttccttc cttccccgta acagctcttc acataataat
tcagttttta aacacttaat
|
83281atttgccagg cacatacaag agccatttac atatttattt
atWtatttat ttatttgaga
|
83341tacagtctca ttctgtctcc aggctggaga gcagtggcgc
gatcttggct cactgcaacc
|
83401ttcacctccc aggttcaagt gattctcctg cctcagcctc
ccgagtagct gggactacag
|
83461gtgYgcacca ccacacctgg ctaatttttt gtattttagt
agagacagga tttcaccagg
|
83521ttggccaggc tggtcccgaa ctcccgacct caagtgatcc
acccacctca gcctcccaaa
|
83581gtgctaggat tataggcatg agccaccacg cctggtgagc
catttacata ttaacccata
|
83641ctgtcctctc aacaatctta tcaggtagga actatcatca
tccccatttt actgtaagaa
|
83701atctaaggcc ccacttggga ggctgaggca gaagaatcgc
ttgaacctgg gaggcagagg
|
83761ttgcagtgag ctgagattga gccactgcac tccagtctgg
gtgacagatg acagagcaag
|
83821acaccgtctc aggaaaaaaa aaaagaaaga aaagaaaaga
aatctgagac ccaaagagat
|
83881taagtaatct tcccgaggtg acatggggag ttactNNNNg
aggcaatatc taaacctggc
|
83941agtgtggctc tagagcacaa gctcctaacc tctgggccac
tgttgcctct ttaccaccgt
|
84001tcgttcggtc cacagtcttc tcctggttaa acatcccgtt
cctcctctgt aaagctctgc
|
84061tcagagaggg tccccctaac cacacaagta ctgtgccaca
gtgtcctgag gtatggtgta
|
84121cctgcatcaa caccaacagc gaatactgac taaacccagt
gttaaactac aggccaggga
|
84181ctattattat cccaactccg taggtgaaga aactaagcct
cagaaaggtt acccaaaaat
|
84241cacaattaga aagtgacaga gcttggactt gaacccatat
ctaggcctaa tactaatact
|
84301ggttcctatg cttggaaccc catggagggc catctcatta
caccaaatat ttcttaaaag
|
84361cttattaata tctactattg cgtttaactt tccaagttgg
aattgccatc ttcattttac
|
84421acatgagcag gtggtgcagg tgaatggcca agtaaagata
ttaacgtggc tttctgagag
|
84481ggacccagtg ccaggagtgt atttttccct ctatacagtt
ataactcctt ctcaactccc
|
84541taaggtaaaa ataccaccac cgactgatca cttattagga
gccagaacac tgccagatgt
|
84601gttacttaca ttttctctaa tttccaaaac aaccccaagg
gaatgttgtc cgttttacag
|
84661acgaaagagc tgaggtttag agaaagtaaa taactatgtc
attaagtcta gaaagtggca
|
84721gaactattgg gacaccctag cttcagcttt tattttttct
gctccataca gctacgtctc
|
84781ccacactttt tctgcgctga gaatgggaga ggggaaaaca
tcaggatcga acaggatcaa
|
84841agtgcaattc caagggaatc acagcttggc tccaatcaac
gcaagtcccg ctcggtaggc
|
84901tgggatagtt ccccaagcat ctctaaaagc aacaacagtt
ggaaatggag acgaaggaaa
|
84961tggaagcgtg ttcttgattt tcactaatga agagttggag
aggtctgaag ttcaattaga
|
85021gggagaaagg ggccagggtc atcggaaagg gccctgggcg
gggaatcagg gcacctagga
|
85081tggcgtccca ggtctccatg acccagacaa gtcactccac
ctctccggac ctcagttttc
|
85141ccatcccctt caaaggattt gaggggaaaa gggagggtcc
aggactccaa cgccctcccg
|
85201actctggcct gagagctgtc cggcctcgcc tctaagagag
cagtcaccac gggccaagcc
|
85261cccaaccctg acagtcagag tgcctgcagg gccgccgcct
cggcggctcg gggcacttac
|
85321agcccggagg gacgccaagc ccaccagtcg ccgcggaagc
gccttcctca ttgctgccat
|
85381cttggcccag aatcccccgc ggcagtccag ctgggccccg
cgtgaccgat ggctcgtctg
|
85441gtgggcgcgg ccccgccccc gcccctccgc Mgtgacttcc
gaagctggct ccacccccag
|
85501cctctctccg ttttgattcc gagcgcctct tccatgccag
gccaagtgag acgctaggaa
|
85561tataaagatg aacagaatca gcctggacac catgtaatcc
tagcactttg ggagaccgag
|
85621gcgggtagat cacctgaggt caggaattcg agaccagcct
ggctaacatg gcgaaacccc
|
85681cgtctctMca aaaaatccaa aaaaaaaaaa aaaaaaaaaa
aaaaaaaaaa aaagccgggc
|
85741gtggtggtgg gcgcctgtaa tcccagctac ttgggaagct
gaggcaggag aattgtttga
|
85801acccgggagg cgaggttgca gcgagcggag atcgtgccac
tgcactccag cctgggcgac
|
85861acagtgagag cctgtccaaa acaaaaaacc caaaaccaaa
caaacaaaaa catgaaaaga
|
85921aattaaccaa attctgtggc ttcttgtgtt tagagtgtgg
gaggtgtgag gagacacata
|
85981ttaatagtta cacaaacagt tgtgtcattt ctaacttgca
ctataagaag caacgatttg
|
86041ctactcactg ttccgagttc ttagcacgga ttaactcacg
catcacgatc ttcaggattc
|
86101aaacacaggc aggcagctcc agagaggggg catccttaga
tttcatacct taaaaaaatg
|
86161attaagattt atctaggtgt actttctgaa gggctNaaaa
aaaaaaaaat ctatccaggt
|
86221gaagaggata caagaaaaac tttccagacg gtgtagcatt
cgcaatggcc ctgaggcaaa
|
86281gaaaatgctg agaacactgt ttttctctct tttgttttgt
tgKtttgttt tgtttgtttg
|
86341agatggagtc tcactctgtc acccaggttg gagtgcagtg
gcgcgatttc ggctcactgc
|
86401aacctccgcc tcccgagttc aagagagtct cgtgcctcag
tctcccgagt agctgggatt
|
86461acaggtgtgc accaccacgc ctggctaatt ttagtgtttt
tagtagaaac gaggtttcac
|
86521cgtgttggcc aggctggtct caaattcctg acctcaggtg
atccgcccgc cttggcctcc
|
86581caaaatgctg ggattacagg cgagagccac cgcccccggc
cagagcactg ttttcaaact
|
86641gtatgttgta ccccactaat tggtcacagt atcaatttag
tgggtacaaa ctttatttaa
|
86701aacaaRgaac tagaatttta tctatctatc atctatctat
ctatctatct atctatctat
|
86761ctatctatcc atctatattt atttattaag acgaagtctc
actgtgttgc ccaggctgga
|
86821gtgcggtggc gtgatctcgg ctcactgcaa cctctgaccc
cggggttcaa gcgattctcc
|
86881tgcctcagcc tccggagtag ctgggattac aagtgcccat
caccgtgccc agataatgtt
|
86941tgtattttta
Following is a GALE region genomic nucleotide sequence that includes the GALE SNP “HT014-AA” (SEQ ID NO:).
|
GATATCCTCCTTCCAGCCAAAGCGAAAAGGTAATTTTCTATATCTTCTTTTTCTTAATGGGAAAAAGATTTAAAAATTCATTCAAG
|
GCAGGGTACAGTGGCTCACACCTATAATTCCAGCACTTTGGGAGGCCGAGGTAAGAGGATTGCTTGCGGCCAAGGGTTCTAAACCA
|
ACCAGGCGTGGTGGCTCACTCCTGTAATCCCAGCACTTTGG[G/A]AGGCCGAGGCGGGCAGATCACCTTAGGTAAGAAGTTCGAG
|
ATTAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAGCCAGGCATGGTGGTGGACGGCATAGGGAAGAG
|
GAGGAATATGGTATCCAATCTAAGGGAAAGAGAAGATGGGGACAAAGACAGAACCTAGCTTCCAGGAGG
Following is a GALE region genomic nucleotide sequence that includes the GALE SNP “HT014-AB” (SEQ ID NO:).
|
TGTTACACAGATTTTTGTGATATTCTGTCACAGCCACCAAAAGCAACTAGCATAGTGCCTCACACTTCGCATTTTTAAAATTTAGG
|
GAGTTATTTTTTTCCTAGAATTGTGGTATTTTAACATACTACTAAGATGAAGACCAAAAAATTTTTGGGAAACTGGTCACTCCTAG
|
GTAATTAAATAATCAGAAAAAGATATGAGGCTGGGCATGGTGACACACGCCTGTAATCCCAGCACTCTGGGAGGCCAAGGTGGGCG
|
GATTATCTGAGGTCAGGAGTTCGAGACCAGCCTGGACAACATGGCAAAACCCCATCTCTACTGAAAATATAAAATAGCTGGGCGTG
|
GTGGTAAGCACCTGTAGTCCTGGCTACTTGAGAGGCTGAGGCGTGAGAATCGCTTGAACCCAGGAGGCAAGGGTTGCAGTGAACCA
|
AAATTGCACCACTGCACTGCAGTCTACACGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAAAAAA[A/T]ATGGAAAAGTGCTTG
|
TACACAAATGATGTCCTGGTTCTGGTTTCAGGTATTAATTGAAGAAACAGATCAATTATGGAAAGTTCATTGTCACCGAGACTTTA
|
AGGAAGAAAGACCCGAAGAGTATGAGTCGTGGCGAGAGATGTACCTGCGGCTTCAGGACGCCCGAGAGCAGCGGCTACGAGTACTA
|
ACAAAGAATATCC
Following is a GALE region genomic nucleotide sequence that includes the GALE SNP “HT014-AC” (SEQ ID NO:).
|
GTCCAATCCCTTCACTTCACAGGGGGTAAACTGAGTCTCAGAAGATCAAGTCACTTGCCCAAGGCCACGCAGCTAGTAAGTTGCTG
|
TGGTTGGATTTGACCGTAATAACCATCGGCTACTGAATGCCCATCATGTGTCAGCCATTTGCTGAGTTTTTTCTTTTTTTTTCTTT
|
TTGAGACAGAGTCTTGCTCTGTCGCCAGGCTGGAGTGCAGTGGCGCGATGTCGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGC
|
GATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGACTACAGGCTCGCGCCACCACGCCTAGCTAATTTTTGTATTTTTAGTAGAGAC
|
GGGGTTTCATCATGTTGGCTAGGATGGTCTCGATCTTTTGACCTCGTGATCCGCCCGCCTCGGCCTCCCAAAGTGCTGGGATTACA
|
GGCGTGAGCCACCG[C/G]GCCCGGCCTGCTGAGTTCTTTAATTGCATTATTTCATTTAATACTCACTGTGATCCTATGAAACAGA
|
TACTATTCTTTCCACCTTACAGACGGGGAAACGGAGTCTCAGAATAGGGGAAATGACTTAAGGTGTCACAATGGCCAGTAGCAGAC
|
CCAGGAGTACTCTTTAGGTCTGGCCGTGCACAAAGCCCCATGCTCTCAAGCTGTAACCCCGCTATCAAGAAAGTGGTTATGCAAGT
|
GGGCCTGTGAGCTCTCAACGTCTAAGCCGTGCGCATGTGAGACAGCGATAAGCTCGCGTTCTCCAGTCTCCAGGGCCTTATCATTC
|
CTCACGCTTTCCTTC
Following is a GALE region genomic nucleotide sequence that includes the GALE SNP “HT014-AD” (SEQ ID NO:).
|
AAGAGTTAGAGACCTCGGCCTCCTGGTCAGTGGAGCCCTTGGCCTCATCC
|
CTGGTGGGCTAAGCGGGCCCAGCTGGGGTTTGAGGTAGGGGAGGCCTTGG
|
[C/T]TTGGCCCCAGCAGCTCCAGGGCCCTGAGTTCCTGCCAGAGGCTGG
|
AGAGCAGGCAGCTGCTGCTTTTCCTGGTCCTTGGTAGGGGAGGGTCCTCA
|
GGCTT
Following is a DPF3 genomic nucleotide sequence (SEQ ID NO: 6).
|
>14:71066151-71351450
1tccaatctgt aggttctcct ggagattgtc acaatctgcc agctctctgg gaatcacaga
|
61accatcatgt ccccttagga tggcagaaga tgtggcacag cctcaatctc caacactgaa
|
121acactgagag agcttgatac gttccttagg cagggcagaa acatcacagc acttcacgtt
|
181aggaaccacg aaagagtggg aacctgRcac acgtgggaag ggcacatccc cagaggacag
|
241aggacaaggg tggcacacac acctacagag accgcaacca catcacagtg aaggaggagg
|
301acagctaacg gggtgggagg tgggagcttt ttgtttgtct gttgctgtcg ttgcttttta
|
361gagaagccag ggtgggccaa atggagatat tgtctcaaga ccattacaca cagcttccca
|
421aatctgtagc ccttttctgt aacctcatga aagctgtgtc agactcagtc ctggtctgaa
|
481gtaccMaagc agcccaaggc aaaacctcat ctgcaagagg caatgcggcg ttgggtccca
|
541aggatcagtg gggagggtgt tcaaaagagc aaaaagggaa accctctttc ataggcattt
|
601ctctcactgg agacccactc tcttggtcat tcctttatga ctgagagtct cagaaggagt
|
661tgtgagtgtg aggtaaaaga gacaagcaag cattttggaa tgatggggat aaaatgttgc
|
721agtggcttcc ctctctggtg cccatacctg gaagaagcaa tcccaggttt gcttcgtatc
|
781tgcaggtcta gagacatcaa tggaggcagc aattggagat ctcagtgtgt ttccagggtc
|
841tctgactcaa ctagagggca tccaaggcct ggtggagcct gtgcaggcct gagcttcctc
|
901gtggagcagc aggtaggcag ctcattccca gggacctggt catccttcct accataggag
|
961ccacctgcca aagcccaccc agaggaatcc cagcgttcac aaatggaggc gccctcacca
|
1021aagccactgg accagcctgt ccctgagaag agacacagag gggcttcagc aatgagaaga
|
1081agaaaaccaa tttcttttgg cttcttagca gagatgctcc atgtcttggc tgtcagagaa
|
1141attgagctta caaattgccc tcaccctgaa cccacttggc aacggggaga tgacctggtt
|
1201gaggtctagt tctggctttt gtgaatcgac cgtgtgacgt agacagcaca gcatcaggcc
|
1261aggaaggcgc ctgatgagac cgtgttctca gcctgagagc gcgctcaagg gcaggtggga
|
1321gatggagcct tctcagagct cagccactgg ctcttgggct cccaggttca tccctcaagg
|
1381agctggggac ctgagggctc agggcccacc actggctgcc tgggggaagt gctgccagtc
|
1441tggtgtggaa agggtccaag tcagaggcct ttgcctcacc ccttccacca gcagggccat
|
1501tcagagaagt cttggctcaa aagaacgttg cccacaggct ttcaagtagg tgagtggacc
|
1561aaacccctgc atgcttttca ggctgtcacg cactttaaaa ccagactcac agccaagcct
|
1621tgtgtccctg actacctcca cagagatcac cagaattctc ctcactggga gtcatgtgcc
|
1681atccagggcc ccagaggagc cttcccttgg gccacccccc acagagaagc tatagctctg
|
1741agccRacatc cacacatgga cagatacaca ccttccccca agcccaggca ttttgcttga
|
1801aagcaaggtt ggtgtggctt cttcagggaa taactcaaag ctgaaatctg gctgtgacac
|
1861gtgtggagaa aaggaaagat gaaacaaacg gtttattcct aatgctgtca acacaaacaa
|
1921cYgagagtct aagccagcac gaagctagga tctgacaagc acctggccaa aggtgagcat
|
1981ggaaggtttg ctgaaaacct ctctgatgct gggtttcatc cctgcacaca ccagcagtgc
|
2041cagatacagg cgtggggcag ctgaccttgc tggggtctgg tggagtgtgc ccaatctgta
|
2101cttgaagccc ccaccccccc agtcccgctc tctgctttct ctagcaggga aaagaccact
|
2161gtgggggtca ttttctgcct ctgatcaggM cctgccagtt gcacctccct gccttccacc
|
2221ccagaaaccc acaagcagct ctggggacac tggctgccca acacactcca ggccaggtga
|
2281cttcatcagt tcaccagttt taatgctgag gatgctgtca tccaagggca tccagtgctt
|
2341ggaaaagcag attaaagcaa ctaggctgag gtcatctgtt ttcttccccc gacccctcag
|
2401cctccacagg gtagaaatca ctggatgcct ccacctgctt gtcttctact gaggaacacg
|
2461catcctcaac agagaaacct acatatactt acaccttccg tgatggcgcg atacttgacc
|
2521tacaatcacg attgcttggc agagcttaat ttcatggctg aaaagcaact tgaaggctag
|
2581gccagcatgY ggtttatttt ccagccccta caggacctag agcattgcct cgcacaYagt
|
2641cgatgccctg ccaagggttt taatttagcc agtaacagcc tgccctgcaa tgattcatgg
|
2701caggcaaaag atgggttcat tttccttcag aggaaaaacc cccagggtgg acaaccatgg
|
2761cagatgagtg gggggcagct tggatggact ctgttccctt tccYgRccag aggagcacaa
|
2821atgcccccta agcatctgac cattcattgc aaaagcatga cccatctgct ttcccaaatg
|
2881ccatgtggac cagaYgcatt ggtgagccag ggacgccctg cctacctacc ccgcctctct
|
2941ccagccacct gctccccacc tcctctgctc tgagataatc attctatatt ttcatgctct
|
3001tgctcacata tcaggcagtg tttctgtcct tttttttttt ctagtaccta atttaggctt
|
3061cttcaactac atgttgaaaa tgtgcacggg gtatattttc tttttcctWt acgccactgt
|
3121tgcttcccac ttcccacctc caccccactc cttagcatct atcacggcag agggaaggga
|
3181ggaaNcagtg cagggaaggg agagggcagg aggagaatca gggtctcagt ggggagtaga
|
3241catggaaggg caaaccaagt ccgtataaac cacaaacccc attctagcca taaaagcttt
|
3301gcatcccttt gatagcagaa ttgagacttt tgaagtaccc aactattgcc aaatRtcttt
|
3361catgaaaaga agcataggtg aacgaaggga agagaaggag agaggtcgcg gagccagtag
|
3421ctttccaagc acaaggctcc ctttgcaacc ctggtggctg tgcagaggct gagagctgga
|
3481ggagcaggac tggagaagac ttcaggaaag atgcaccttg cctggcagcc cctggctctc
|
3541cctcttgtcc tggagcaaca tcaaagtttc cctttggttc attaagtagg gcgtgtgtgt
|
3601gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt atgtgcgtgc gYgcacgcac gcgcatgcac
|
3661atgggcattc ctgttctcat catcaatatt cataacattg aaatgaagaa cagagatgca
|
3721gagaggcgag caaatgagca aatgggatgc agtgagtgaa aatataacct gggagtctgt
|
3781agggttgtgt tgctgaggga atatRtaggc cccaggggct cacaggcctc tgccatttcc
|
3841tacaaggccc acttacctgc cctcccgtcc ccaccatggc cgcgtttatt tgctagacag
|
3901ggttggtgcc agcctacagg gccattttgc tcaatgcctg ggctagaggt catgataagt
|
3961aattatatct ctgtccaaga gggttctggc tgcctgccag tcctggttcc tgccttcctc
|
4021tggcctgccc tgggaaatgt cgccatcagc aaaatactcc cttctcctgg tggagccaaa
|
4081gaaggggaac tgtggaaggt ccctctctca aggccacctg ccctatgacc tgaggttggc
|
4141actggagcag agaaagggaa ggagtgggga cagaagctgg aacaaagggc cctggggagt
|
4201cacctcagga ccccctcaca gccagggctc actcaRaacc cagagagagc ctgttcccag
|
4261gaacccactc acttccaaat ctttcccctc atgcagggag ttccctgttc cttctagaaa
|
4321acccatggta Sggaactggc aagcccggac ccctcctcct cagagtttcc tgacagctct
|
4381tcctttgggc ctctcttcta gctgcctggg ctgcgcacat ggagggggcg cccgccgcac
|
4441agccaggcct ccccggggac agctgctgag aggctctaag gcagttccca ctcgctctgc
|
4501ctgggaggYt gtctatcctc ccacatcccg ggtgcccagc aggaagcacc cccatcttcc
|
4561tctcccctcc ttccccctgc cccactctca gctgtccact cacagaccag agggtctcca
|
4621gcctccctag gaaggggttc ccagctctcc aagacccacc accagctgcc caaaggcctt
|
4681gaaccaaccc atctgtccca ttgtttccac actcagggct ggtggccgtg gcctctggca
|
4741gagaatcata agcagactcc caaaccctgg gaatgctcag aaatggggga gggagcccca
|
4801acccccagac agctatggag cccaccttct gaccacggac cagttagact ctatggcaag
|
4861ctggggttca ggtagggaga ttcataggcc tgaggcaaat taaaacagct gttccccacc
|
4921atcaccatcc ttccccttca cctggtatcc aaaagcatRc tttggggatg ggagtaagat
|
4981ttcaaaacgg gcaacacaca gcaggaagRg gaggagctct gtccactttg cagaggggag
|
5041aggagcagga tggccagtcc ccctcttccc ttcccagcta ctggtgtcct gggcttgggg
|
5101gacaggggcc tgggggcctg acccctctgg tagcagtgcc tggaaatgct tcactcccca
|
5161aggctgcagg catgatccag ccctccctca ctgccttctc tccccagctg ggtgaggggc
|
5221ttactttgcc ctcagaagca tccctgaaac cccacacaac caacgggcgg cctcaagaaa
|
5281gagggagctg aatcagtgtt cagaactggg cagaggtttg gcctttttac aaaataataa
|
5341taataataat ctgttgccca ggatcacaag cctcagaaaa aaaaaaaaga gttacaatca
|
5401ctgttcactc ccacctgctg ccctccagct ccttagctcg aggatttctc cctgaggaca
|
5461tccagctctc tgcctttttc caccagagat cctcacccct cccaaatgcc ctcccaccct
|
5521cccttcccca ggcacccctg tctttctccc tccccaggaa tggaagcctg ctaaaaggga
|
5581caccaagtca ccactgctac caggagccag gcctgggact tgcggcatcc tgtgggagtg
|
5641tgagcgtggc tctggccaga gccaacttct ccctcRggct gagacatggg gaccccctga
|
5701agaggggcta ggaggggcag ccggggagtg agagaagaag gggctgcttc tgtcccagca
|
5761cttccacgac aggctaaaaa ccagcctggg gggcagggat gtggtcctca gggcccgccc
|
5821tgggccacgg gcggcgcaac accccctacc tcctcacaca cagacccaaa gaggagacta
|
5881taagcccctc ttctttgagt cctgaggcct gaggttgcca gcaacctttc ttcagcggca
|
5941taaaagagca caggtctcct ccacttgccc cgaaaggaaa agtaataaca atcatctcat
|
6001ttttcttcct taaaacatca aaacttttta agcggagggt tgaaaggaag cgggctgtat
|
6061tcaaagcacg aatacaaaaa tgcaccagga gtgtgcaacc ctccagggta tcatgaaacc
|
6121atcactgtga aacccaaacc ctcccccaac ttcaaaacct gttctcttcc ccagttctgg
|
6181aggaatctgg cctccttccc tcccttccac ccacccacag gctcttccct ggttccagtc
|
6241ggctgggctc agcctgccca ggcttccggc ttcctacctc gccctggggc agggacagga
|
6301gcaggggagc cttgggacct gctggctcct gcttcagggg cgatgagtca gtgaggggtt
|
6361ccaaaggaaa gccagaatgt caatctccta gcaggagccc tgtttctatt tccacataat
|
6421gttgcctgca ctggatttgc tacagatcca aaaagcaggg tttcaaaaat gcctacagga
|
6481aacaggattt ccacttccgg ttgggtStgg cagcctcacc tctctggttt gctggagcca
|
6541cagtacagag gggtgaagcc cagcaaagtt ctcctggctg ttcccagcat ttgagccgga
|
6601agacaaccac atcattatct ccatttggtg gcctctgcag aaaatgacaa tagctaccat
|
6661ggagtgggga ccatcatcat gccagacccg ggccRggatc tttaccaatg tcacctYgaa
|
6721tacctgcaaa gaccatgctg gataggccat gtttccccac cttacagaca tgtgaaatga
|
6781ggctcagaga gttgaagtca ttggcccaag gtcagtcagc tagaaagtgg cagtgttggt
|
6841cggaaagtga gcgttaccca tgaactgaaa caaatcatag ccctctctaa aagtcacctt
|
6901tccattctca actgcattaa tcttatagaa ggagtatcct gagtaccttc attttaaagt
|
6961ccccaacccc atgtacatcc ctcacctcca ccccacagcc catgcaagtc atgatttcct
|
7021tggtcgcagc ccagccctgg caatataaac tccctttggt cacaagggag atttgaagaa
|
7081gacgtctaac attggctaat gcacacaaga aggcggacat ggaaaacatc Yggagttctt
|
7141cccagacaag catggctctg cagtgcttgt ttatgtaaca tgatgcttaa gagtcccagt
|
7201gtcactctgg aataggcagg gcaagtgtta ctatctccac tttccaggtg ggcaattgag
|
7261gttcagggag gttaggtgac ttgcccagtg tcacacagct actccatggc agaggcaaca
|
7321caaaaactct gatccttcac atgcatccta tgattctatc tcattctctg gggttcaaaa
|
7381aaaagagacc aatttaaagt ttaccaaccc cgtcctcttt tgaacacaga ggtgataaat
|
7441gtgaccacgg agacttttgt ctgcttgtag taccctgaca gtgccagccc acaagctggc
|
7501ttgctatccc cgctttccag atggggaaac tgaggcctcc aaagatgaag aatgggttgg
|
7561gcccattctt cagggagtaa tgaagctgag aggggaactc cggggccatc ctaacgtcac
|
7621tccagagccc tgaccctcac cagtgcaggc aagttccagt gccctgcctt ggcctgggag
|
7681acccagctga ggctcagctt gtgtaggcag agcagacatg gggctgagat cgaacagggc
|
7741tgccctatca cctgcacttc tgtggaaaac aaatttgcac atactctgaa gaggacgtgt
|
7801gaagttgtag agccacagtt tggggtttcg gacttgcttt ttaaactttt aagctattgt
|
7861ggcacttggg aaYatttggg gaactttttt ttctaaattt aaattaaaat gacgctcaaa
|
7921aNcaattatt agcctttgga gacagcctgc tttgggtttt gtgggaagag agagagctgg
|
7981agtagtcagg agaaaaaatg tgcccctctg atggaatgtc accctcccta tccctccctg
|
8041ggccttcagg attcagacaa gctcaccgac cagcaggcgg aaggaaatta cttatgagga
|
8101agatgaaaat tccatccggt cgggggccct ttaaatgaga ccattatgta tgtgtgtgat
|
8161tccctctgag gccacaggcc cctgcaggag agtgaccccc atcgcttgcc acaggtcact
|
8221ctgctgaagc gtgggggaga cccacactgc ttggtttcat gccaggctgc cctgggtcca
|
8281ctggccaaga gcaattagcc tagagaggag cactcctgcc gagggacagc acaaatactg
|
8341cggccgggca gaggtggccc aactagcccg agtctccggg agcgtcctca ggagctgaag
|
8401aactaaaaat aacctgggcc tttgttgtga gcagccagac cacagagatg gagctgattt
|
8461cagagaagcc aagcatgcgc gagggttccg ctcaccgaga cctgcccttt gggcaaatga
|
8521tttttccaga aatatgtcag ttattgtgct gctgctgcga ttcaaagtca gcccaatccg
|
8581ctccagccct cggggctatc ttccaacaca cagagttctc ggaagctcag cctccccacc
|
8641tctttcttct aRacacattt ttttttgaaa acaagagtcc tgcatgtttg gggagcttag
|
8701gagacaagag cagcccccgc actgagagtt ctaaaatgtg gccaccctgg tcgtgaataa
|
8761tgaccatgtc accctaatta tttgtttaga taacaatctt ctctccccca tcctaaaatt
|
8821cccagtcagg tctcagtaga caatagcgaa caaacactac gtggaaggaa gaaattactt
|
8881ggaaaaagga attcagagcg tcgcatcaat actgaaggtt tctcaaagct gcagccccct
|
8941gtatccagca ttcggacaca tgattgggca gccttcgctc cccttcctgg ttcttcagtc
|
9001ccaccaggag aagctgaacc aggtctccag aaccaggtgg gctgagaggc agaggcttga
|
9061ccgtcttcct ctgtccatag gccatgactg gtctcaccta aaggatgccc cagctctgaa
|
9121ggtcaaggaa ccagcctggc ctcttgcaaa gtctctcccg atggataaca agtactgact
|
9181ggctatggcg gggccttggc accatttcca caatgtttcc tcccatgtct ctgcgcgtct
|
9241ccctccctcc ccgcccccat ctagtaactt taagcagtgg ctcaagacca ggctggctgt
|
9301ggatgccact gctggggttc tagaaggcaa ctctttgtct ccacagacac caaggaacaa
|
9361gaaagggttt caagacccca agtctagaag tttccagtga ggcttgccat aaacgacaac
|
9421ttctccacag ccctttgttc ctcaggtgag aatttcagga tgcagaccct aagctggggg
|
9481cacgggggct gtgccaagat ttcttggaac acaatagata aaaaaacacc acactacaca
|
9541caagtaatgg atgagtggtc aggaaatggc ttcccttaaa atgggaacca atgagagggc
|
9601ctcggtgcta gggtaaaagt gagaggggtt ccacagggct ggggccggag gtgttctccc
|
9661aaagtgcaac ttccttccgg tagagacaag gaggtgctgg ctgaagttcc gtacatatcg
|
9721ggggaggtca ggagatgcct caccctcttc gttccatgtg tccctgcccc tctgggacta
|
9781tttcttttcc ttgcagttgg tctggctgga tatgtgRgag gagggcgcgt tctggtttga
|
9841actgggctct gctttaggat ctccagcagc gagtcacatt ctgtgacctg gggccctagg
|
9901cctggcagcc aaaggctgag gctttctctt tgagcagttc ccagcataag tggcagctcc
|
9961agcttcctgc aagaaatgag acggctttag tagcagcccc tctgctaact ctggagcccc
|
10021accccactgg ccctaacttc ttgtaaatcc tgtttccttt gaactttggc aatgcagaaa
|
10081ccaagtccca ggcctgaaaa cgtgccagag tctgtggctc agcagaaagc aggtgctcag
|
10141aggagatggg ctcaactctt atcaagaccc tcactactag cgtcatgcct ccaaactagt
|
10201gtcgccgggc ctgcgccagt tctcctggaa gctcacacct cccggtcatc tccactgcat
|
10261gtctgggaaa aNcttccttg gccctcaagt tgaaatttca gctgcttgga ctgtgcctca
|
10321gtttcctcat ctgtaaaatg gcagtcgtcg tacctacctt gtggggttgt gatgattaaa
|
10381tgagacaaga catgaacatg taaacccatt agcataaggc ctgtaccata gtgagagctc
|
10441agtaagtgct agtagtagta gtatctgttg ctgttcttat tgttgacttc atcatcatta
|
10501ccttctgggg gctcagccac cgggggattt aaacagtaca tgtgatagcc tcggtcacag
|
10561tcatcgcaga agagtagctg gtcctggtgg aacacagagt aagcacagag gaggagagat
|
10621tccattattc ggggccaatg tctggccccc gcttacccat cagccttatt tccacgtcgg
|
10681tctcactgga tcccctttcc aggccccact tggagtcctc actgtcccct gaacacgcct
|
10741gtgcttttcc cacaactgga gtttccccct ctacctccca gcctatataa atcctacccc
|
10801cattttaggg ttctgctcaa ctYgtacctc ctccaagacg ccttctgtga ctaacacctc
|
10861acatccaaat ttaaagggat cccttattct tctgaacttc caaagccaat agctctgctt
|
10921ccaaagggca gaaaatgtct ctattctcca tgactttata tatttgaaga tcttaattga
|
10981attcttctgg actccactct ctccatctgt gaaatggcca acagctgtac tgggatgaac
|
11041ctcagaacct cttcagggtt tcattagaat gtagaaaaat gcaagtagcg ccatccctcg
|
11101gcttccagaa gcttcctcac tgtctggagg ctggagcccg ggtgagagca gggcacccca
|
11161gggttgtggt taacttcaaa ggacacaggc catatctttg cacctatggc tacttctgcc
|
11221tggaggctct cccaggccct gaccctttct ctgcatgtcc attccctgcc tgcccttcaa
|
11281gtacgtcttc ttcaagcact tcttttccac aaagtctttg ctaatctacc tcaactggaa
|
11341gttgtctctt ccctcgtgca gccctgtggt actttccctt tctgtgacat ttaaatgcat
|
11401tttcctttac gttacatgcc tggcatgtgg tagacatcta atcacgtttg ttttcttggc
|
11461tgggYgctgt ggcgcatgcc tgtaatccca gcacttaggg aggccaaggc gcgtggttca
|
11521cttgaggtct ggagttcgag accagcttgg ccaacatggt gaaaccccat ctctactaac
|
11581aatacaaaaa ttagccaggc atggtggcgt gcacctgtaa tcccagctac tcaggaggYt
|
11641gaggcaggag aatctcttga acccgggagg tggaggttgc agtgagccaa gatcgcacca
|
11701ctgcactcca gcctgggcaa ctgagtgaga ctctgtctca aaaaaaaaaa aaaaaagaca
|
11761tctacatgtt tgttttcttg aatagttcat ttggaacatg cctctttttt ccacccttta
|
11821tcccctttat ggactataaa gcccttgggg gcaaaatctt gttttcctca tcactgcatc
|
11881cactgtagag acttccttgc atacaggagc tgctcggaaa ctgtttgtga tctggcccca
|
11941ccccctagtt tcagctctgt tctatttggt gattgttgaa actgtttgga tggcttatga
|
12001gcctttttca aaataaagtt ttatatcaaa tctcaccttg gcccccacca gtgcagaaat
|
12061cctggataaa attagatata gctgttggaa tccccaggga gcaagcaatg agggcttttt
|
12121ttgtcatgct aaaacccgtc agtggggcaa caggaaagct tttgaagagt tatcaaYagg
|
12181ggagtgatac gatcagattg cagtttagaa agatcttact agctgctatg taagagtaga
|
12241tacccagtgg gggagaggtt cattcaagag gcccggggac cagttaggaa gctgctatag
|
12301ctatccaggt gcgtgatgat ggtggcctga attacaattg cggcatggag aaagaaatgg
|
12361gtcttgctcc catttaagca tcattgatta gatggggaga gtgataggga agaagccaag
|
12421gatgccgtct gggttgtggc ttggtcagca agccagatga tacagccacc caatgggaca
|
12481tgggaggaag agcagactca tgggagggag agggcaacct cagctataga catgttctac
|
12541agatagggat gacctggagg ctgttgaaga gagcaggaga gaagtctggg cctgagatat
|
12601ggaYttggga ttcattgtaa ttagatggca agtgaaggtc ctaggagagg aagcccagaa
|
12661tgtgtgagag caaatgtctt tgaccttgtc ttcatggaga agtgtccatg aaccccttga
|
12721aatgatacac acaattttgt acataggtag aaatgtacat ttttctatgg aaagagtaag
|
12781tccgtagctt tcattgaatt ctctgaaaga tcaaggaccc aaaagagttt actgagaaga
|
12841aggccaagag tttactgaga agaagtacac ttggggtact ccaactttac aggacaggca
|
12901gagaaaaaaa gactgaaaag gaacagtcag agaggtggga tgaagacgag cacactgtag
|
12961tttacgccaa aacagttaca tcattattgc agagccagca taagctacag gacaatttga
|
13021tttagggata atacaaggag aaacaagtta ggatggagac agaaaacaga caggacttgt
|
13081cagaaacagt gttattaatg ccttaaaaac agtaataacc cctactacag cagtgacatg
|
13141ggaaatacaa ataggtagaa tatcctggat tacaatttcc caaaggaaaa ctaggcatct
|
13201gagagtttaa gtgcattttg catgggttga ccactgtcta gcaccatatt ctcttctctt
|
13261ccaccaccaa gagcccccag cttatgctaa ctctcatgac aaacacaatt ttagtacctc
|
13321tcactaccaa ctatccagga accaggaatc acctattact acRgttccag cagaatggga
|
13381atcccattct cggatatcca gggtaaatcc ctgaccatgt gagaggaatc ctagtgcccc
|
13441aacaacctca cccSctgact cctcctcaaa ggctctgcca agtcaacaaa aaaatcctct
|
13501acatttacac tatctgtaaa gccaaagacc agcgtcaacY taaatgtcca tcaataaggg
|
13561aatggttgga taagtaaaaa ttatgcagct gtaggaagga atgaagaatg tctatatatt
|
13621cctccagatt aatctctaag atattcagag aaaacaagca agatggagaa aacatatata
|
13681cttgttacca tttttcatgg attcatatat acacacacat gtttacattt aaacaaaatg
|
13741gaaagacaaa tcatattttt tagtggttgc ctatatgcag agtgaaggaa tagtgtggaa
|
13801gaggtaagta gagagctaca tttctttgaa tataatgttt ctttataaat ttgattttag
|
13861aaccaataaa tattttacac agtcataaaa caaaatttaa atagcaatat gtccctaaaa
|
13921aaMacaaaag aaaaatgagg caaatgaatt tggttatgta tccaattggt agcataacca
|
13981cacagagaga aactattcca tctgactata aaacaattaa tttgacaata catccttagt
|
14041aggacatacc ttaaggtcat acataaatgc agatctgcat atatatgtgt gtgtgtgtgt
|
14101aatgttcagc aattatatta ttggtttaaa tattggaatc aatattctga gactgcttta
|
14161tgtgcatcaa atgagtaatt atgttggtat tattgaagag caagattttg taacatggtt
|
14221gaaagaaaat agaaatgtag gccaatgaag ttaagtcaaa agtcagtagt tggttctaag
|
14281tatgaactgg atgcatcagt ataaattcat ggtgtagtgt atctttaaaa caagcaaaaa
|
14341atattttcta cctctgtcca cagaaagtgc tccaaaacaa tgactaacag caaaattagc
|
14401acctctagca cccatattat gttctctaaa gaccattgcc cactaaaagg aattaggagt
|
14461cctgggagaa ataagtgatt ccaggtctgg agcataaaat gtataaRtat atttacatat
|
14521tacaaagtaa ggaagctatc aaatactatt aggattatgt caaaaggact caggatccaa
|
14581cctgaatatg ttaccactgg tcaaagatgg gacaatttta cctataatgg attataacaa
|
14641ataaaatatg tttaaaatct taagttcata aacatatttt ttaaaacctt agtcaccttc
|
14701agaagatgct agagaaacat cacactatat ttttatttat ttatttgaaa taattttaaa
|
14761cttagagaaa agtgcagaaa ttatgcagag aattgtactc actgtgccct aatattaaca
|
14821tattatatta ctatagcaga attacgaaaa tcagaaaatt accattggtg taatactgtt
|
14881aactaatcta cagactttat tttaatttct ccagttttcc cacctatgtc tctttttttt
|
14941tttttttttt tttctgagac agagtctcac tctgttgccc aaactggagt gcagtggtgc
|
15001catctcggct cactgcagcc tccttctccc gggctcaagc aattctcctg cctcagcgtc
|
15061ctgagtaact gggattacag gcatgtgcca ccatgcctgg ctaatttttg tatttttagt
|
15121agagacaggg cttcaccaag ttggccaggc tgttctccag cgcctgacct caggtaatcc
|
15181gcccgcctca gcctcccaaa gtgctgggat tacaggcgtg agccaccacg cccggccccc
|
15241aacctatgtc tctttaccag ggatccaatc caagatccct cattgcattt aattgttgtg
|
15301ttttctcagt atccttcaat ctgtgacagt tcctcagttt ctttgtcttt catgagcttg
|
15361acactttcaa aaaatccaag ccagtgattt tgtaaatgtc actcaatttc agttggatct
|
15421tttctcatga taagatccac atatgcatac attttttagc aagaatacca ctaaagtaat
|
15481gttgtgccct tcttggcgca tcatatcggg ggaaattgag gccagtacgt cttattactt
|
15541gtaatgttat ctgtgattat atagttaagg tagtgtctgc catttttttc actgtaaagt
|
15601tactgttttt ccctttgtaa tatactaata agtaatattg ttggggagat acttggagat
|
15661tatctcctca acaagagaaa taggatattt gagattatgt aaatatccta cttctcatca
|
15721tacttttgcc cactaatttt agcatcaatt gacagttcgt ccttataacc ataactgtga
|
15781agtgtgccca atgattattt cccctttccc tctacattta ctcattggaa ttctgctcta
|
15841aggaagagct taccttctcc tctgtttact tatttattca atttttatat tagtatagat
|
15901atttattttt tctttaggtt ataacctaat aatgtcatta tttttttgct caagttttcc
|
15961tagatttggt cattacgggt tccttcaagt tgcttcctgt gtcctctaga cgcatgaaaa
|
16021tatcctttca ttttttgaac acttccttac tttctgacac cacataatcc tccaggctta
|
16081tctggcatat tttgcatccc agccctggaa tcagccattt ctctaaggat ccatggttct
|
16141ttttatgaga gaatggtgtt tagaaaccaa ttccttgatg ccatgtgtct tcattgcttc
|
16201tgtgttgtca ttgcttctag gccctcccag ccaacacagc taggaaataa atgtatgtgt
|
16261aggtacacat gcatacatct ctacttattt ctgtctatta atatatgtgt acacatatgg
|
16321ctagatataa tatgtataaa ctatatataa cacattgtat gtaaaatcat gaattcatag
|
16381tgatacccac tattccaaac caatgccttc aatctagcct tccccccttt atttggttat
|
16441tctttttctg actttgagaa actagactct cattagtcac aatacacagt cattagttca
|
16501aatctagcat acgtagtttc agaattacta attcatatac ctatgaaaaK aaattaacta
|
16561gagtacagta tttgtggtgc agttatttct gtccttagct ttacaacaca cagtcaaaat
|
16621actgttttcc aaagttactt aggttattct tttcttcctc actcttcggt atagttacat
|
16681tatctattta cgttatactg tttatttgtt actgttttta tttcatttta gtttttccct
|
16741acatcttggt tgattttaag tatttatcta tttgggaggt atgtaaaacc ttatgatggt
|
16801tgtaagagtc aaagctatac aagaaagtat tctcaaagaa gtgttgtttc tcccttatcc
|
16861ctactatccc attttcattt tcccattttt ctctacccca ttctcccaga cccgtgtagg
|
16921taaccagtct cattagcatc ctgtttattc ttcttatatt tcttttacac aagtgagcaa
|
16981atgcatgtag gttttcttat gtctcttttt tcttacaata aggtcagcat actatagata
|
17041ttctatttta ctttgctttt ttacttaata tattctggaa atcactccaa atcaattcat
|
17101agacatctgc cttattcttt tttacagctg tatagtactc cactgtatgg ctgtgccatt
|
17161gtttattcaa caactactct tccatatatg gatatttagg ttgtttccaa tattctgtag
|
17221taatgaacaa tgctaccaca aataacctta tgcattccat catgttgcag gtatatcttc
|
17281aaggtagatt cctgtaggtg agaatgctta gtcaaaagtt aagtgcatat tagctctgtt
|
17341aggtattgtc aaatttccct ccccagggtt gtactaattt gtattcccac caacaatgta
|
17401tgaaggcacc atttttccca tagcttcatc aacaggatat attgtcatac ttttcaactt
|
17461ttgcccatct gataagtaag aaatgatatc tcagctttga gtttctttgt gagtgcattt
|
17521gaactttttt ttttttttgc atctttaagg gtcattttta tatcttttgt gggttgtctt
|
17581tcatgtattt ttctcatttc ctatcaggtt tctggtcctt tgtcctcaat ttttaacact
|
17641Yctttttata tagggaatta gcccttaaac tgtggtacat gctgccaaaa tttcctccca
|
17701gtttgtcagt tgtcttttga ctttatcatg tttttgacta tgcaaaatgt ttatgtagtc
|
17761agatatacca acattttatt taattgcttc tggattttga gtcacagttt gaaaaccttt
|
17821tcctgtattt agattaaaga ggaatttact tgtgctttct tctagtacta gcgtggtttt
|
17881actttgtaca tttagatccc caatgtattt ggtgattatt tttatgtatg gtgtaagata
|
17941taaatctaat tttgtctttt ctcaaatggc taccccattg tcccagcacc attcatttaa
|
18001aagtctgtct ctgacccagt aattttagat gtgaccctta ccctatactg tatttccata
|
18061tgtagttgga tctatttatg ggctttctat tctatctcag ctggtctatt tctctcctca
|
18121tgcatcagtg ccacactgtt ttatctatag aggctttaca gtatgtttta atatctggta
|
18181gggctagttt ccatcacagt ttgtttatca gtattttctt gcctattttt gcatgtttgt
|
18241ttcttcatat gaacttaagt atcgatttgt ctaactccat aaaaaaagtt tgttgatatt
|
18301tttattggac ctgagataaa tttataaatt aactcaggaa gaactgacat ctttataatg
|
18361tcaagtcatt ctatccaaga tcataggatg cctttcaatt tgttctttgt gtttttgaaa
|
18421agtgtttaaa agttttgttt atataggttt tgcacatttg ttgttaaata tatccctaag
|
18481tatttcttct ttgttgctat tataaatgga attatgttct ctaactggtt attgtttgta
|
18541tatgagaagg ctgttaatta tgtgtgttag ttttataatc tgttaccttt tatgtttgag
|
18601ttagcttatc attgattctc taaggttttc cagatatact atcatataat acaaaaatag
|
18661agttttatta ctttgttatc cattcttaca tctctaatta aattctcctg tctaattgca
|
18721ttaggtaatg tctctagaat agtgtcgaat catagttata gagatagtga gcatcctccc
|
18781ctggttccta atcttagtgg aattgtgcct agtgttttcc tcattaaata agatactggc
|
18841tttagttcta aggtacaaat actttatcat gttaagaaga tatcccacaa tcactatttt
|
18901taRtgttttt atcataaata gatattttaa ccacactgtt tttttaaaac tgacaaaggg
|
18961aaagaatcaa gcattttttt cctgccattt ctatatgatc tacacctgaa ggtaaccaaa
|
19021tgaaagattg ggcaagttta tcttcctgga attactccag caataaacaa aaaagaaatt
|
19081atccaataag aatatcacta ttttgcaacc cctaacaaaa tagtcaatcc agtcaaaggt
|
19141catcaataga tgctaccttt acaaaaagag aaacatcagg cattatacat cctgatgaaa
|
19201gtgtacacca ccatctatga agtagtcttg ccaaaagaga gagagagaga gagagatgga
|
19261gacagagttg gtgagaggag agagagagat aaagacagac acagaaaaag agacagacaa
|
19321tctgaatcaa gcctctagcc ctaacaattg acaagaaatt caagagacag aggaaaatgt
|
19381cagacagcac agagRtatac tcagtcaaat acagtcatga gaacttgaac aaatgatctg
|
19441atttcttcaa caaagaattt aagggaggaa gaaagagaat aagatggagg gaaaagtcta
|
19501tgtgttattt aaagaagcta tatgtaWgtt tatatgcacc tacagatatt taaataaact
|
19561tcaaagacat atcaactaat tgcaatgtat gggccttatt tgaatcccaa ttcaaataaa
|
19621caggctgtaa tagaaacatt tatgagacaa ctgaggaaat atgagacgac tggatgtttg
|
19681attgtactaa ggaattattg attttttagc tatgtaatat tttggttatt taggtataaa
|
19741agtaagtcct tatccttttg agatacatat gaagtagtta caggtaaaaa tgatattatg
|
19801acggagacta tggagaggga ggtcatggta tttatgaaat aagattggac gtgtactgat
|
19861ctttgtcgaa gctggtgatg gtttacatca attctattat tctctctgcc tttgtatatg
|
19921tttgaaattg cccataataa aaaatgttct tgaaaatttt gcacttatta tatttaacat
|
19981ttagaccaaa tgagatcata tactgtggaa tgtggtggaa acaatcaaat acatccctgc
|
20041cataagcagt gttaaccact gtcagtctct gagccctcaa gggctaatgg ccaggttgct
|
20101cccaagtgcc agggtaacag gccccagggg cctagtgaca agagtccttc cttcctcttc
|
20161acccctcaaa ggaccccagc tctgtggatt tctccctccc acagggaaag ccccaaactc
|
20221acatcattct ctgaggtccc acagaggata caggatttgc actctatgca ctgccacttg
|
20281taggtcttga cagcctcggt catgttcagg gtaaactgca ggcaggttgg gtgacctgga
|
20341ggaagccaga aacaacagca ttagggccRa agtatgaact gccacccctc aacaccactc
|
20401actggaaaca cattgatgcc cagtgtgcag gcagggcagg gtagcatgac gtagggaaaa
|
20461aaatggggac ccaaacaggg ccctacccac attcttcacc acccMgttat tcagatcaag
|
20521ggcaaaacag agatataagc acatccaatt ctgcttgcac tRagaccata ttccccagca
|
20581ggtgtaacca gttgatgaag atggaaaaca atgatcagag agaacgagag aggaaactgc
|
20641agagtacaca gcctggggca gcactatgag agacaccagt gggaccctcc aagccccagc
|
20701atcagctatg gcagcacaac aggtaagaac tatttggagc tgggccttct gatccaacca
|
20761gttattcaca ctgccttagg gtgcaaggga ggctatcaga aggattgtat gaggtttcca
|
20821gggtcagtgc tcagggatag gatgaggcat tgcactgtta cctaaagtat ccatgcccac
|
20881actcatgaga ctagcaaaag ttcataWcct gaacagtacc acggactaca gaaggaagtg
|
20941gcctggcaRg gatggcaaag aaatggagca tcagagcaaa tggccaggtc tatcctaaaa
|
21001ggactggttc ccggttctaa ctcttttctc catcccaagt ttcatgggag ccaacccaat
|
21061cacaagatga gagaagggac attaagctgt gaccttcaag cacagccccc gtgagccatg
|
21121cccaagactt ggcctgtgga actggactct gtcctcagac ctaggtcacc taaaagagag
|
21181atgcttgcag ggagaggacg gccatgaact gtagaatgca aagacccttg gccttctatg
|
21241tggcatggaa ggataacttg gatgacattc ccaagtcKcc cagtactgtg aaacagatca
|
21301gaatctgccc agaRcaccca gggcaaagcc aattactgac tctgtcacaa aaaacattga
|
21361cagctttgcc cagtgccgag cactcaccgt tctccagagc ttccagttct gccaaaccca
|
21421ttatatggtg ccttgtgttg cctctttcat ttgaaggatt atatgcttta aagaaggatg
|
21481ctagagacag gggacaccaa tcatggttag caccgccaac ctagtatcct ccacagacag
|
21541gatcccccat ggcgccacca ccccttggca aagccacatc ttaacaggag cccccatttc
|
21601ctccctttca aatcttcaga gagctgttca catcatgacc atttggatga aatactgtct
|
21661attcagccaa cataaggatc cttcacattt tgagctccac aaatagaaac catgctgagt
|
21721tatcttggag agggcgaggg gtgtagaaat gacttgttgg tggtggggag gggacactca
|
21781gtgaatacag gcagaagcag caaggagagg cctgatctaa aagcttttca aggacttctc
|
21841aggtaccatc caacttagag acttccgcag ctctgaacta ataaccctct caaggtgata
|
21901ccatSacagt ggccccaaag aaaaagaagc cttacattaa aagcctgtgt gaacagccag
|
21961ctgatattct tgaaagcatc tcaaagattg gtctaagaag aacattagcc agggttactc
|
22021cctattccag tctctcagag agaacactgg gatgggtaca gggtaggaaa tatctgtttg
|
22081ggactccatg tggtatgacc acagatgccc agtttctctg accaggcacc actgagagca
|
22141tgaacatgag gtcatggagc tgatgctcat ataggcaagt tgactttggc cagttctgtg
|
22201ccacacccca gccacaccca gccagcttag gataactatt cattaactta cSaagtactt
|
22261attgagcacc tacaaggcag gccattgtgc tagacagaaa agacacagtg gggatgagca
|
22321agataccttg agcccttcca gcctagccaa agaggcctca gattaatcag ctacacatgt
|
22381atctatcaac tacaattgta taattagtgc catgaaggaa aagcataatt ggccgtaaaa
|
22441acacatagaa gaacctaacc tagactgaga tgacaaggaa accttccctg agaaagatct
|
22501ttaagctgat atgtgtcaga tgagacgtta gctaggtggg aagaggagga ttccaagtaa
|
22561ggggaacagc atgggtggag gctttgagca gtgaagcagc ttagcaaatt acaaggaaga
|
22621gaaaggccag tgagcagagg cttgatgagc aaaaggaaag gggtaagagg tagctgcaga
|
22681ggtagctgga gaaggattac aggcatttgc agcccttatt taagaatctg ttttttaagt
|
22741cattaaaggc tattaagcaa ggcagtaagt gggtcacatt ttgtttttaa aggagcactc
|
22801tttagcatga gtgctattgg gatgaagtgg ttctgtatct tgattgtggt ggttacatat
|
22861gtgataagat tgcatagaac tgtacataca catacacata tgtatttgta catgtaaaac
|
22921tagtcacatc tgaataaagt Ytatgattgc attaatatca attgcctggt tttgatattg
|
22981tgctataatt acataagatg ttgcccttgg agaaaactga gtgacgagct caaggacttt
|
23041ttgtaatata ttttgtaact tcctatgaag ctataattat gtcaaaataa atagttgaaa
|
23101atatattttt aaataaggaa aacaaataaa aaattaaatc atcaaaaaga aaggaaggtg
|
23161gaaggcagat aagaaaaagg agagagagag gaaggaggga aggaagaaag gaaggaagga
|
23221aggaaagaag caggaggaag ggagggaagg agggagggaa ggaaagaagg aaggaaggag
|
23281aagggaagag atgaaaggga cagaagggaa ggaagggaag gaagggaaag aagggaagga
|
23341gggaaggatg gagggagggg aaggggagag aagaggggaa ggggatggga aggagagagg
|
23401aagaggaggg gaagggaggg gaaggggagg ggaaagggag aggggagggg gaaggacaag
|
23461agaaggggag gggaagggag gaaggaagga tgaaggggct gtacgctaag gaaagaattg
|
23521ttgaggggtg ggagggtaca gSaatgtaag aattgttgcc aggaagctag ttaggaggct
|
23581aatgcagcta ccaggagaga tacaagaatg attcaactaa ggtggaaatt tgagaaatgt
|
23641taaagaaata cttgacagga cttgactatt gtttgaatgt tgggaatatg ggaaaatgat
|
23701gagaaataat cccaagttct gacccatgaa actaggtaga ttgtagatta cagtgaaact
|
23761tagatgagaa agactgtaga aggattgcag ggaccacata gaggaagagg attccttctg
|
23821tgttgagcat gctgaaactg agaattctgg tggaaatgtt gagtggatag ttgaatgtat
|
23881gggtcgaaat tcagaagttt ttgctaaata ggtgataagt gaaaccatga gaattaatga
|
23941aattatctag ggaaaaggga atgaggaagt atctagggaa agaaaggaag aggagagaag
|
24001aaaggagaat agagaaaagg gtctaggact gagcttggag gagctcaagt cctccaagat
|
24061caaaagaaag aaccagcaaa ggaaagagag aaacatggca agaggtaaga agcaaatcgg
|
24121gtgagtatgg ggtcacagta accaaaagaa gaggtttcaa gaaggagaag gtggtcaact
|
24181gtgtttactg ccacaggttc tctagtttgt ccttgctcaa taaagacccc gagtgaggga
|
24241atgttgacag atcagggcaa aagctaccct actaataata acacgcttca gtcatgccat
|
24301cttcccaagg aaggaaagtc agcacattcc agagcatgac agaactcagc agccaaatgt
|
24361gcatctgagc tgtctctgtg aggaggggcc gggggtggcg tgtgctgcat gcatgtagca
|
24421acactccacc aatatttatc gagagccagc tctgtgtctt agttctctaa gactcctgtg
|
24481ctgagctatg aagacatttt ctgggatagc tttggacaat ggatggtagc aagtgggttt
|
24541tggaaatgcc tgttggaagt ttctgaaaca atctcatggc tttctctgtg ttcccatctt
|
24601gagaaagtca tcagcctcct gaagatcttc aaacccgaag caagggagct aagttcacac
|
24661agcctcaagc ccccgaYaaa atgcaggact aagatgggcc ttagcagtgg ctgcaggaac
|
24721tccttctcct ccacactcag gacatcactc aagcgcaaga agaaagtagg ggagggaaat
|
24781actattgtaa cttctcagcc agggagggtg agacacaaaa agtttaagtc atcagcaggt
|
24841gcaaaaactg tgcccagaac taaatcctcc tgtctggacc accataacag atttgctcct
|
24901gcgcctttct ccaaaaactg cagaaatcat ttgccagaca aaactgcaag aatgagactt
|
24961cttacctgcc acaaaaatta cttcaataat acacactgtt agacaaaaRg aagtgtctaa
|
25021ggaaagtaat agcagcttgt ttctaaggtt cactggtctt acttttgccc agaactaatt
|
25081cctaaatgct ttgaaagtaa gagaataaca aatacggtct ttccaattca aaggtgaaag
|
25141aaaaaaagag gcacatggct ataaggtaat ttgtaatact tatggtcact tgatatttga
|
25201ggatccctat cttaatctct tttgtaaagt taaccctcat tctctagggt attaggctgg
|
25261tgcaaaagta attgcagttg ttgccattaa tggcaagtac tgcaattact tttgcaccaa
|
25321cctaatactt gcttggaaat ctagattttt tcatagcccc agttttcttt agagcaagaa
|
25381atacccatat tgctatttaa atagcctact atagtggagg gaagacaacc cttcccaggc
|
25441ccccctgggt gccatgattc aacagagcat ttataagatt ccaattacca aaatgaattt
|
25501agaaaatggt gcactgtgca tgattcagcc cagccggatc attaaaaacc tagtccttcc
|
25561cggatgttcc tctaaatgta ttctatcagg agcattcagt aaatctcctg ctagcttRtt
|
25621gagctgggtc agtggtgaac ttggtgtgaa gagccattcc tgattcagcc ctaacccttc
|
25681cagaactgac ctcaatcctc cctagaggtt gacactgggt atgtcaccca tggccactat
|
25741gtatgggaga tctaactgct ggagtgggct tttgggagat cagcatttgg cttcagggtg
|
25801ctatttcagc agatggaggg aaagggaaac caatgggtta tgggaaactt ctcagacaga
|
25861tgataatcca tgaggctggg agtacccggt gtttctgaca ctacagccta ctgagctcag
|
25921taaaaaagga aaggcaggca tctgagagca gtgacagcag ccttggcact ggaaggacac
|
25981atctcatgtc tttacagaaa catgtgcaca gatgctgaaa atgttcaagg gacagcaaat
|
26041gggatttgtg gtatttgagt gagaaggcac acagataaat aYccaggcaa aactagtgtt
|
26101agtttcatat tcacagctgc caatttctat gcacgMtaat acacaactgc cccaacacaa
|
26161gggtatttcc agccttttag gggagaaaat atctaaatat accttgtgga ttaagctgac
|
26221attatgattg caacttaaaa gctaacctaa gtcacttact agtcaacctc ctctatagat
|
26281attcagtaca ttgagagaaa cacagttcat tttcaacaaa ccctgggcaa aagaaataca
|
26341caaactgcta tgacatgtgt ctcttacatt atgatcctta ttaaaagagt ttttatttta
|
26401ttatcaccgg tatttaattt ggactaggct aagccacatc actgattgaa ttagggctcc
|
26461aggaaaaaaa attatcttcc taggtatgca Ytgaaaacat aaataaaaca aatataaata
|
26521actttggaat cagcatggtc tattatttat tcattgtgaa attataaaca tctaattata
|
26581ctttattacc ttatttatca atgttgatct cttaaaagct aatttctcag gcaaagagaa
|
26641cttaaatatc catggttctc aggcaagtaa atgcaaaact caaattgtgc tccttattct
|
26701gatgcttggt ttacagaaat tgtattacat aaaatacata gaatcaattc caacccaaaa
|
26761tagcgccaaa aacaagtctc catgggcatt cattagaaaa taatttggct caaatttcaa
|
26821atagttctct atattctcat acacatataa aattcctggt atttacaaat tgcaaatgta
|
26881tatatgaagt tttagctaaa gcatttatgc aaagtatagt catatctgaa tcatcatgct
|
26941acagggtaat ttgagaagaa aaattattac tagttctctt tgggaagcca tctcattcaa
|
27001tcagatccat tcattttcat tctctcactc ctctcttctc tctttctctt ctctccctct
|
27061tctgtctctc tctctgcccc attccctccc cctctcttca tgctcctcca ctttgagacc
|
27121cagcttggca ggtggagaga aggaggctca gtcattatat tgaatctgta aaggggaaag
|
27181ggatggacca attctgagca atcaaaagtt caactccttt atgtatatac tatggcaagt
|
27241atgataactg ggcactgctg cttcacataa ttatttctca agccctgctt tgtaaacctt
|
27301ctgcaaaggt ctgcaggttc acctctatct gcccccagat gttacttcta atgctgaaga
|
27361cacctgcaaa tcgatgatca caatggcact ccagaggcat ctgaatggct ccctttttct
|
27421ctcaccattt ttattgcact tcaaagagga caaagaagag aaagagaatg gaaaggacaa
|
27481ataccaaaca aacaaaaatg cattaaaaat aaatgatagc gtgagctgtg tggctgccct
|
27541ttcttgggca aaacaccttc ctgtgcatcc agctccactc ctcttagagg tttgtttatc
|
27601ctctcctcca gttgtcaagg tctgtggcac ccaggaaaca catgggatgc aagccccagg
|
27661ggctattgca ccagtcattc ttataaataa ccatacaaag cacattcatg caagagtatt
|
27721acgggcactt ttaataggct aaacagccaa gggctcatgg cgccattctc aaatggtcct
|
27781agaaattccc caagttttcg tggtcaggtg tggtccaagg tggagtctct aggaagtgga
|
27841tctacacctg tctataagcc tgagggcata catcatggtt ggtcttctta aagtgaaata
|
27901atgggatagg gaagccttga cctggattta tacaatttac tcgactcaac ttggggccaa
|
27961tgcacagcac taggaatacg ttgagagtca tagtaatgac cccaaagccc ctaattagtc
|
28021actgcagctg aggatcaaaa ataatttatt catttattca ttcctttgac agtatttgtt
|
28081gaatatataa atatggcagg cactcttcca ggtactgggg atatagcagt gagaaaatcc
|
28141aaacccctgc cctcaattta caactgccac actttgagat atattacagc acctgagtcc
|
28201tttggacaag tcaattgact tctctagcat tagtttttca atatattaag ttaaagcatt
|
28261ggaatctgct atccatgaag ctgtagcttt gtctatgcca cccaaaaatg gtatttttaa
|
28321agatactact gatccccaat tgcccatctg cttggtggga taaacaagcc ttctaaagtt
|
28381tgccagctaa aactgaaagt taaaaaagaa aaaaactaag aaagaaatta aaatagccag
|
28441taagtccttc tagaattcat gtcaactttc ccatattgac cagcccagtc cgatccaatg
|
28501tcgacacaac aaaagatggc caagacagaa agcaaaagaa atctagaaat ctaaaggact
|
28561tttcatcaac cataccaccc accgccatgc aataagttag gcctatacag atgagctgtc
|
28621ataaactgaa ggtagacaga ggccttgggt aaggttccat cgatgaggaa tattagatct
|
28681gggatgagct aggttgagct gctgtgtgac agctgcagat attgccaggc aggaagtgac
|
28741taagagaaga gggtcatcgg tatgagcaac tctggatgac tttcctttta aatgcttctc
|
28801tggatttgta gattgcaggc aaccagctgc ccaaagtgat tcttgcccca caacagtgtg
|
28861tgaaggtcag gcNgctgaat cattgYccag agcccaacat caattttaga tgccaagcct
|
28921tgacatttgc tgtgcattcc aggcctctct ggacctcagg agcatccaac catgggacct
|
28981ggctaaaggc tctgtgtttt ctttaggaaa atgagcctga aaaagaaacc attgcttaga
|
29041ttggaaaccc tgtaatccct gtacttccta ctgtcctgag tacatccagg agaatttcaa
|
29101aatgNNtgta attgatgtat agctggtgga aaacagcagt gattggtcaa cacttgattg
|
29161cccatgatcc tccaactgct gatcatccat gaattagaag atgaattcat gagtggtcta
|
29221agttcttgag ttgcctgagg acctttgaag tagcattcta attttttctt ccaaaaaata
|
29281ttccacagag ttgtgctaag tcaaaaggaa aaaatgcttt cctatccttt tctacgtgag
|
29341cctgggaagc aatcatagaa gtacctagaa gtagaggact gacagtgtac tcatgacact
|
29401tagacacttt gttttacatt tttttttttt tttgagacgg agtcttgatc tgtcgtccat
|
29461gctggagtgc agtggcgtga tcttggctca ctgcgagctc tgcctcctgg attgacgcca
|
29521ttctcctgcc tcagcctcct gagtagctgg gactacaggc gcccgccacc aYgcctggct
|
29581aattttttgt attttttagt agagacgggg tttcaccgtg ttagccagga tggtctcgat
|
29641ctcctaacct tgcgatctgc ctgccttggc ctcccaaagt gctgggatta caggcatgag
|
29701ccagtgcgcc atttttaaat cattttagtc taattttgag tgttcttgtg gactttgcaa
|
29761tctacccaat tgtgatcaga ttctcataga aaaataattc cacttaattt ggcaaaattc
|
29821actgagcacc tgttcattgc caggaactgt acaaggtgct gaagtttcaa agaggaatga
|
29881ggcatgactc ctgccttgag gagctcagtt tggtaggtgt gctaggcagt ctctggcgtg
|
29941gctatcaatg aaggacacca tactcttttg tcattctccc cccttgagtg tgggctgcac
|
30001taaatgactc acctcaaact agtagaatat ggcagaagtg atgagatgtc acttataata
|
30061ttaggttata aaaagactgc aactttcatc ttccgaatcc tctcttatgc tttctcactt
|
30121acttgctcta agggaagcca gctgctatat tgtgagatgc cctacagaca ggtccatgtg
|
30181gcaacatatg aaggaaggcc tcagtgcagc agcccaaggg gaactgaatc ctgccagaac
|
30241ccacacgtgt gggcttggaa ttgaattatc tcccaagtga gccttcagat gagaccacag
|
30301ccccagctga caacttgact gcaacccaag ggaggccttg ggccagaggc acccagataa
|
30361aacacacata gattcctgac ccacagaaac tatgagataa taagtgtttg ttgttttaag
|
30421ctgttgagtt ttggagtaat ttcttacaca gataactatt atatatagag agagagactc
|
30481ttttaaatga ctataataca atgtgataag tgccataata ggagaatgaa tgaagttcct
|
30541acagataagg aagcaataaa taatgctgga gaggctcagg gaaagccact gagaggaggt
|
30601agctttcaag ctgggcctta aaggataaat aggagttttY taagtaaaaa aaaaaaaaaa
|
30661aaaaaaaaaa aaaaaaaaat ggaaacagca ttacagggaa aggcaacagc aggaaatata
|
30721aggtgcatgg tccactcagg caaagcagag tagctcaagg agagcaggga aaagaggaat
|
30781tgcaggagat gatgctagaa Rggtatgagg aaagattatg aagagcctct tatgtaggca
|
30841tgaggatctg aatttaattc tgtaaacagt ggggactcct cggaggtttt taagcaagaa
|
30901actgatgtgc ttgtacccat gctttagaga gatgagtctg gtgataggtc agaaggcaga
|
30961tRtgttggag atggctgggg aagggggacc agtcactaaa tccatctatt caatgagttt
|
31021gtattgagca cttgcaatgt gccaggtgct gtgatagatg ctgagcaatg gaaaacagac
|
31081aaaatcctac ccttctggag cttacactgt aatgaggggc attagtccag ggcagatcta
|
31141ataattgtgg ggatgaaagg aggaaacatt tgagaggtag aattggtcaa taggacgtga
|
31201tacctgcttg aatatgtgtg tgaggaagag gcagaagtaa aaaatggcat caagattcct
|
31261aggttgggcc acagagtaga tgataaaact gttagcagag atgcgacttg cagagtataa
|
31321caatggattc aaactgggca cattccatta attgtgcaga tgaagatgcc caggaattgg
|
31381tgtgaaaatg tgggtctaca ttcaggagac aagaccaggc tagagatata aatttagaaa
|
31441tcatcaggtt tgggtggtag atgaagcctt ggaagttggt gagacattca ggaagagacc
|
31501acagagcaca aaataaaaag gacctagtta ggggtagagg gaagagtaac cattggagtt
|
31561gaaagcgtta aagagcacca agaagagagt ccactgagaa agctggagac aatgtggtca
|
31621gaaagggaga agtatctgga gagaggcacc tcatgacatc cRaggaagag gaagggtggc
|
31681accaccatca agtgacagat gaagtaagat aagaaacaaa gagaacgtgt tgccctgggt
|
31741gagccattgg tgatgagaac taacacagtc actagtagca atgggccctc atgcctctcc
|
31801aaatcactga tggcttcagc agcgcagaga gaagaactca tacacagatg gcctcacaac
|
31861atgcttcttc tgccgcaggc tttgtccagc actctcaagc ttggaagcac cgtgcacaat
|
31921gatctcagga acattgtctt tacctaactc cattcactca tagcaggaat cattttctga
|
31981tgtagattct ggggccaaag ctaggccctg ccagcctcag tttctgtcct tcccccggcg
|
32041atgaatcaaa tcccactgga agccgtgcct ttctttctga ccttggatcg aagatcttca
|
32101gtcctaggtg actgagcctt gcccacaagg ctggggcagg tcctgatgga ggcttctccc
|
32161acagccccag agtctgatca agtggcagtg atgaaaattc tccaggaggg aagttggggc
|
32221caaaggtagg aggagcagca ctgggagcca aacggaatgg tgaggtgagg acagaaatgg
|
32281tggcaggcag caatgttggt ggctgcagtg ctttgcaaaa atgcccacaa attccttggt
|
32341cctcctcttt tcaagaagtg gaggctattc ccctcttctt gaatgtagac tgggtttaat
|
32401gacttgcttt taacaaacac agtaaagagg agtgacaata tgcagttttg gagactaagt
|
32461tataaaaggc actgtggttt ctgtcttgac tgtgcactct gtctctatgt ctctgtctgt
|
32521ctccgatcac tcactctgga ggaagccagc tattgtgttg tgagctgcct catggaaagg
|
32581cccacatggc aaggagctga gggaagcctc tgttcagcca gcaaagaact gagactctca
|
32641acgcagcagc tcatgaggac ctgaggccta atggcaacat gagagtgagc ttggaagtga
|
32701ctccttcagc cctgatggag ctttgagatg cctgcagcct tggccaacat ctggactgca
|
32761gcctcatggg acaccctgtg acacaccacc cacccaagcc attcccaggt tcccaaccct
|
32821cagaagctat gagataataa atgtttgcag ttttaagctg ccaagttggg ggataatttg
|
32881ttacacagca atagctaact aatacaatgg caaaggagga acagtaaggg gcctggctga
|
32941acaccagaca tttgacagaa ctcctgctta ggcagtgtct gcattgtgct cccagccaca
|
33001gtgaggccca gcactgggct ggacaatgaa ggagaggagc agggtttggg attttagatc
|
33061atttatctct tccatgctgt tattattttt tttcagtgaa tctcctttaa aagagctaat
|
33121agtgggaaca aagataattt cagtggcaat atgaatgggt gtgacccctc agcatttaca
|
33181gcaaggtgag tgcatctgcc ttcggtttcc tgggtccaac ttgtttccat ggcatggccc
|
33241gaggagactc actgcaccaa agagcctgcc gtcttcccct caggccttgc cctccatgcc
|
33301cctgtctcac tctcaccctg ctctgccttc cttccacctg cctgagcctc tctcacctcc
|
33361aacaagcctc ccctttaggt tccccagaac acaaccccag tgttagaaag tcagaggctt
|
33421cctagaagta agccaaactg atatgagcag aggaagaacc tgcagctagt attctggcct
|
33481aaagaaagcc atgtttggat actttaatga tccttataac ttttccaagg aagcaccttt
|
33541ctattgactg attttgtttt gattccccgt ggggatcctg tgaggtgggc agaacagata
|
33601ggaacattcc tgatttacaa atgaagaagt tgaggctcag aatggctcag gcagcccgca
|
33661agtaagtagt ggagccaggg ctagtggaac atccatgtct tcacattcta atcctttggt
|
33721ctctcactac accatgtcct aggatggcca acccaaaagt ggcaacccaa tggcatttca
|
33781gctccttgtt taagctgcta aatatagcaa cattttctcc ttgcatgcat aagaagtttg
|
33841ccagggcatg atgaaatatg tcactgactc tctccatgcc tcagtttcct ccatttgcac
|
33901cacataaggg tgaactagct gtcccctcag gcccctttaa gcctcaatgc tccatgcctc
|
33961tagcgaaatc cctcaagaag ccagacttgc ttacatgagg cagaggactg agtcctcacc
|
34021atctggcagt gactaatcct ggaaaaccct ggggaagaat tgctcaggag tgagccagtc
|
34081cagcccacac aaaggggcct ggaggctgca ggaagtaggt cagcagccta tggtggtgtt
|
34141actgggcttc ggctcctgac agaagctcct cagcccctgg ctggagtgag gaggggtcat
|
34201gccccccgcc acctcacagt cccactcaga cttgccaggc cagctattcc cacttgcagc
|
34261tgggtgtcca ggtcctccct agggctcccc caagtgaccg cccatcacca gctttccctg
|
34321tgaagcctct gagaggagca caaaagacgg ctggcatcca aagccaattt cacRccacac
|
34381ctccattaca ctgtcagtca agaaaggaca gaagtgttcc ccactcacct tgtctaagaa
|
34441aggaacaaaa gagcacacag gaaggatccc ctttttgtca tcacaagact ataYtacaat
|
34501Sgagacaccc acaaccccac ccccactgga gaccccaacg aagSctcact ggctcctttc
|
34561aatccttttc cccctttcat tctccacctc ccgatttccc caagtcatga attcactttc
|
34621caagttgcag tggcaggaga atggaaaatg aggatgatga tggtgacaac cagctttccc
|
34681tgaagtctct cacccaggtg tcttgagccc tggagacacc tgatgtcctt caacaccctc
|
34741aaaaagaaga aacagcaatt gcactgagcc aacactgcat acgggagaaa catccttgga
|
34801gctccatggg agtacaacaa aacccggcac catctggcgt cgtattacct ctgcatgcat
|
34861ttgcttccaa gccccaacat ccaggcagca ccgggtctgc actcctcctg tatctgtgat
|
34921cactaaaccc aactgataga tctgtttcca tcggccaaat tttcatctaa gattcatcca
|
34981cttttcctga caatcaaaca aatatttatc caacaaattc ctgaatgaga attgatctcg
|
35041ctgcttactt agaaagctag aggggatgat ttttacatgg gctttctttt tttcctctgg
|
35101agaaattaga gagttggaat agtacaagag aaagcaaatc aatggctatt tccagtgacc
|
35161agcatctgtc ttcaggttta atagaaatga tgccctaaga catatagtct atttggccta
|
35221ttcaatacaa aaacacccat caatattaaa gtagtgcagc aggagggcct ttcctggtac
|
35281tttgtaaggg tagacaagag cctcacaagt gttcaaagat tcacgaggcc cttctggata
|
35341agcagtgaca aactccattc cataatcaga gaaatgaaac catcaaccat ctctaaaatg
|
35401gctctggttc acctgagcat taggtgtgag agaattagga atacatcacc agaaatctga
|
35461cctcctttca gggatagcta aatatgtggc acRtatacca ccattctatc ccatacccag
|
35521ggcagacatt actaatcaat tcaacattgt cttccaatct gcatggataa gaccttatga
|
35581tccttttcag cacMgcactc caagtggctg tcactggtct agagtttgca tacaagaaga
|
35641aaccaacttg ccatccctga gctaggcact attaagctga ataggttaaa agtttcatgt
|
35701gagaattaag gactcacatc ttaagcaggt cactggtcag atatataact tctgttttcc
|
35761tttccatgag gcagaaactc tatcacaaca gctaagaccc aaaccaaatg gtggccatgt
|
35821tttgtggttg gactcaagta ttgctacggt cacatacttc tgtcttcaaa gcaaacagag
|
35881atgctaagaa gggatttttt Nttttttttc agagataggg tttcactctg tcacccaggS
|
35941tagactagag tgcagtggtg caatcttggt tcactgcacc tgccgcctcc ttggctcaag
|
36001caatccttcc tcctcagcat ccacgtcccc ctacctgcct cccccagtag ctgggactac
|
36061aggYatgtgc caccatgcct ggctaatttt taaattttat atagMgatgg ggtctcccta
|
36121tgctgcccaa gctggtaaga agggattttt taatgatggY Kaatattttt tctactccac
|
36181cagctagaag gcatcaaccc attcctcctt aagtaattcc tctgtctttc attgcctgca
|
36241gcatgaagta agcttcttag cattgcaagc ctctttgctg tctggccaca gctgcctttt
|
36301taagattYct cttcttttcc caccatggac cccaRcccca ccataccaca gaaaagtatt
|
36361tgccRcatcc cacaccctca acgctcctac accccccacc ccccaaaaaa ccactcttct
|
36421ttttgacttg cacttttgca cacaaaggtc tctcactatc tctcaactcc cattcatggc
|
36481caaacctNtc aaacaggttg tctacactcc ggctacacaa aagtgggccc atcgaccact
|
36541tgcatgagca tcccctgggg gctggttaga aatgcKcacc ccggatctga cctagggact
|
36601gcagttttaa caagatcccc aggtgattcg catgcacagg Rtattttgag atgcacttct
|
36661ctaaactcac tccctttctg ggacacccac tcagtcttca ctctctccac actgacttcc
|
36721ctcctctctt ttccaccaaa aaaactctca tcaaaggagt gaatgtgtcc atgcagatat
|
36781gaataaaaga ataataaact actacttcca ccttttgcct gtcctgggaa cttctattca
|
36841tcctccaagt ccagtccaaa agacctcact tctgtgatgc cttctctacc ctctaacgca
|
36901gataaggaaa ccaaagtcct gggaggatgg gaWatctgct tacagctctg cagcYactaa
|
36961gtggagWcca cctgactcca agcccatgag tgccctcagc atcgccagtg cactgccttt
|
37021acgaagtgca tccagaaaga tgcccacaac ctcagataaa agccctttgg ccactgtcag
|
37081ggacaggact ccaaggctgg aaccagtaaa acaagtctga ctttgctggt ggatgagacc
|
37141ccatggaggc tgctcataaa tcagattccc ttgtttaagt tcttagcccc tgatgactac
|
37201tgcttaccca ggcctctcaa tctccctgaa gacctttctc caYccccttc cttcaaacac
|
37261acatcccagg cacccatctc ttttgccctc cttgcctcca tgcggaattt ttcctttgga
|
37321gaacaaggac ctcagagtgg aaatgtccat cactggtctt ctcatttctc caagccacag
|
37381caatgccatt ttggcgaccc ggctgctctc aaacttcaga gttcagaaga attaccggga
|
37441gagatgtttt aaacatgcag attctcaggc cccaaagctt ctaattcccc tgccctggag
|
37501tgggtaggaa tctgcctgtt tagctagtgc cctgaggggg ctcagatgca gatggccctg
|
37561gacacacttg gagaccctct gctgccagcg tctcctgggg actcttgcac atcagcaagc
|
37621tgctctataa tgcagcgtgt ggaacctcag ccaagtcttc ccaccactct catcctgagt
|
37681cagccttgct caatgagggc tcgaaagcct ttcctgccca cctcatcctt cttctattat
|
37741gaggatcaag accatgggct atgtactact gctttgttaa gctggaaaac tttaaaagaa
|
37801caaaaggcca aggtttacca ctcttctgct ttgttttggc accactaaac ctctacgccc
|
37861attcccagaa attctgtatt tctttcaacc ccatagccca ttgtcgacat acccgtaagt
|
37921gtttcagaca ggcctgtgat tgttgcatgc aaaggacatc aatccatact ggcctgtatc
|
37981caggcacaag ctgtcttccc gatagcaatt ctccttgcca gagacctgtg ggtctcctgc
|
38041ataaacagga ggtcttagct tctctcagca acttgagaca ggcaccatat actctctccc
|
38101caagataaga tcttttagaa gacaaagcat ttagattatt tcctttgtag gattaaaaac
|
38161aaacacaaat gcccattcca gtatttgtag gactgattca actggagtag taggaaagat
|
38221ttaggataca tttaagacac ggtttccatt gtttcactat gaagctttga gtatctttgc
|
38281aacctaatta gattgcacct attaaatgat gactggattc aacagcccYa gaacaagcat
|
38341tacttttgat cattttctat tttagcKtct attcaactat tttaagagga atatacctga
|
38401gccaaaaatc acgaggaggt ggctagcagt agcaagattg gtcctaattt attgagggca
|
38461gtgaggcaga caccaYcaat tctttaatct cgccaggagc tccagtccaY ggacagtacc
|
38521acttctcacc atatctcctc tcacgtcgtc actgctcatg cacctatctt agattccaca
|
38581tccagccttg cacgtgtctg cctacccctc tacccctttt tcctacttac tcaacttcca
|
38641gttaatacca actcttcacc tactcttggc ctataccaag cacagaaaaa tacaccactg
|
38701tgctgagcag tcgtggtttc agtggtgacc acagatcttg tcattgtccc cgtatttcac
|
38761tagtcgaatt attctcccat ctctctctgt cttttcaaat ctcccatatc ttatacccca
|
38821tcctcacact ctccttattt agttgaaaaa tacataaaca atcagaataa aactattgcg
|
38881ccaggcgtgg aggctcacgc ctctaatccc agcattttga gaggtcgagg caggcagatc
|
38941acttgaggtc aggagttcga gaccagcttg gccaacatgg tgaaacccca tctccactaa
|
39001aaatacaaaa ttagccaggt gtggttgtgc atgcctgtaa tcccagctac tcgggaggct
|
39061gaggtgggag gattgcttga aaccaggagg cagaggttgc agtgagctga gatcatgcca
|
39121ctgcacactc cagcctgggt gacagagtga gactctgtct caaaaaagaa aaaaaaaaaa
|
39181aaaaaagaat aaaacgatcg catcttctcc atgccacacc cacccagctc cccgcctctg
|
39241tatccctacg cttgtctccc tcctattacc gggaatgaac ggtctcagct cctaacccaa
|
39301agccgactgg caccaggatc cctacctctc accctgagaa ttttgctcct gctgttattc
|
39361cctcttgcat cgtcaatgtc tctctctctc tctagYagac cattcagcca gcatacaaac
|
39421aagccataaa agctcccatc ttccaaagag atccttcctg accaagcatc cccctctgtt
|
39481gagcgtccaa tttctctgct ccttcttctt ttagcacaac tggaaagggc cagttctctc
|
39541catgcccctc ctttccacac tctcccctct ccacacactc gcctagctct cctcccacct
|
39601cgctggctgc cccttcttgg tcttctttgc tgaatcctcc tcttctccct ttctcccagt
|
39661tcttcctttt atgtggactc acttcccctc aatgtcttct atMcacttgt tattcccaat
|
39721ttatatctcc agcatgaacc tctttctgaa ttccagactc atatatccac ttgtcatggt
|
39781ggttgggaac ccgaagaata Raaagttaaa aagacctaag ttaggaaagg attttgtggg
|
39841aaaatcctca tcccaagggg tgatgagtac cctgccagcc aggaggggag ccttcagctg
|
39901gggggctgtg gagtctttat ggaggcagga ggtggaactc acagcaagca gaaaattagt
|
39961tgaatggcac cagctttagg aactgccagg atgcactttg gatcatgaat aagtaaagaa
|
40021aagaggtcat cacaggttcc agaagagtga ggacagagag aagcaacaaa gtgagaaRag
|
40081gaagaaggaa ggagacaaag aagacaggat acagagaaga agggggctgg aaggagtggg
|
40141tgaaagaata agaactcaga aaagagattt tggttcttgc ttattcagga gcttaaccag
|
40201aattctgtct aaactcttta aaagatgcag aaactcaatt gtctcactca tccctgggtN
|
40261ggggggggga ttaatgtatt agtactattg ctacaacttt atgaggcgct tcctatgtgc
|
40321taggcacttt gaacacactt ccttatttac ctcttaaaac aatctgtgac tcaggtatta
|
40381ttgtctccat tttatagaca aagaagctga agctcagaac agctaagtaa tttactcaag
|
40441acaacccagc caactgctgg cagagacagg atgaaaacac gtatcttatt ccaaccaaca
|
40501tccatgcaag taRccactac accgctcggc cacaggaaac aagcactggg aaagaccctt
|
40561cccctgacac aggaggccga gcggctgatg agcaaactcc agagagcact gggctCtgaC
|
40621catccggtgg cctcccctgc cagagggctg gggcaataga cacatcccca cctgtgctaa
|
40681agtcctgctt tcctctccac aaccctcccg ccccatccac actccacact gcccttgagg
|
40741gaaaaatgag gacccagagg atggcctggg gatgaggggg gactgctcat tagctaccca
|
40801gccgtggtag ctaatctaag atccgggaat aaaggccctc cctgaatgac cccagggcaa
|
40861aaccaggtca aggccacttc caaaccccRc cccgacagag ttaaaggcga ggatctagaa
|
40921aggctgaaaa cacaaagaag ttaatcagct ccctgaaatg aaaggggaga aaagagactg
|
40981gataaaggga tcagctgaag gaagcagcct ggcttgggag agaacactcc actcagccac
|
41041gagtccacag actcaggcca gcactgcccc gggggccagg agatcttggc Ratggctctc
|
41101tgctgtctgt ttccttctct gttagacaag ctctagggtc tttgcacctg acagctgagg
|
41161atagggcagc acctgtggcc aacacagcct catctggagt gggtccagcc aatgctgtga
|
41221ccagcggctc tctgtaggtg cacaccccat aggtaccctg gatccacaca gatgccccct
|
41281ctaattccat gctgcctctc catctgcctc ttcaaggtaa aaggtggatg gagctagggg
|
41341gtcagaagga gtcacaggga tgggtgagct aagaggacaa aggaggcgtc tccctccaag
|
41401acaggatcag cgtgtgtggg tgggaggtat acaaaacgcc atctctcctc cacagacacc
|
41461cgggaacact gcctgaaact tccaccactg atgtcgctcc agtggcttaa aaaccaccct
|
41521tccaaaaatc cccagttaaa atgcaaacaa ctttcttaaa gaggatagca ctatcatggg
|
41581ttcctcactt gatcaactca gacactgtca gaaccagagt gaatcttgga gaccaccaag
|
41641tccaacccct tctttagaca cagaaggaaa ccaagcctct aagaggtaaa gtgacttgct
|
41701cagggtacag gaagaggtgg cgcagagcta gaactgtaac caggtctcct aagtctttct
|
41761gcagcatggc cctggcccct gagggaggtg gcccaggatg ggggcgggca gggggtctgg
|
41821aatcttggca tcgtgctccg gggctgctcc ttcttcctgt tcagccacca cRgcaaacaa
|
41881gagcccctgg ggcctcagcc agcgactgac ccctccctga ccctgccttc cggaaggatg
|
41941aatgcacatc agaagccagg gccaaaatat tcctgggcac tgtctgctgt gcacccagct
|
42001ctctttttcc cagcctctta ggagggagaa gtttccaaaa gggacagctc caaaggcttt
|
42061cacagaaggg gagcctctct aagaagtgct cctgtgtttg ggcaatggag gYaagtcagg
|
42121aagacagggg gatggaagaa gaaagtaatt ttttgaatgt cacattttca ccaaaatggc
|
42181atctgggaac tttcaagatc atctgactaa taccaggttg tattcgttat ttgcaaagat
|
42241ggaggtggaa tctcctttga agtagtacaa ccaaatgatg tctgtagcct tMaaatgggg
|
42301taacaagagg caaagaaatc tggggagagg aaacgtgtcc tgccaggggc tgagggtctt
|
42361ttttgctctc ctYctgacag tctcacagcc agccacgtcg tggtagggtc ccacagagct
|
42421gcccagcatg gggcaggctg gccagagcag ctggctcttt gcaaccaccc agattgcctt
|
42481tgctgggaag ctcaggctca tttgcacact ggcataactc cacgtcactg accagcccat
|
42541gggcaacagg actcacagcc aggatgggtt ctccctgggg ctggcacgac tctgtcactg
|
42601cacatgtgca ttttcctgat cctgggcaag ttactgaaac tttctcaacc ccagttctcc
|
42661agctataaaa taggaacacc ccctacatca caggattgtc acataaggga aaatgaggct
|
42721agagaacctg gggtaacgtg gaattgactc tcagtgagcc tggttccctt tctctcgcaa
|
42781taaaagccgg caccacctgc tccaaaggta aagcctatgg ggaaagtctt tcccagtgag
|
42841ccctgaacaa gacagagggc ccttccccac aaagcttccc aggcttggag aggcgggtgg
|
42901tccccatgac tcattggtgg tggtgggctg actcatttgg ccaactgtcc ttaatttccc
|
42961tcctcccatt ttgggagtcc tggagcattc gttccccaaa tgaggcttgc agccagaatg
|
43021agctgtgatt agcacagcag agaccagaag gatggtgctg gggggaggcg gggtaagctg
|
43081cagagagttt cctgaaatta aggcaggaga agcagggagg caaggtcttt ctccctgggc
|
43141catttagcag acagagactt cctttagagc caaccttctc aacctctgct gggcaaaatc
|
43201aactcagagg actgcctgca atagccctaa tatggccctc agaggcagac ctggggtgtt
|
43261tatcacagag cacaccatga aatttcaaac cactatgtag gtaacatagg tgggtgcata
|
43321aaacagaaca ttgccccatt gcactgaatg cacaatgaac agtgggcccc agaatgcggg
|
43381ctgtaccaga tctacataaa tattacaatc tgaaggcaga tgaacaagag ggagtttgca
|
43441agggttgggt gagaccacgc tgtacaaggc ccaggtgctg tatagatgat gcagaggtgg
|
43501gtagggtggg aagagaggtc aatgtgaagg ctcacatcca attgtttttc ctttcctcag
|
43561gaggaggatg gatattcttc tgttgtgggt ttcaattcca tgctgtcaaa taacctcttt
|
43621agtccaatgc tctgccactt tcagccaggc ataagcaaga caattgtcac tgaacattat
|
43681tgggagtaac atgcaatggc acatgcacta atgcgaacat cagaaggaag acccggagtc
|
43741tagtctagcc ctatcacttc tgcacagctt tggcctgagt cacttaaccc ttccgagtgc
|
43801tggtctactc atctgctaag tgggacaatc acttctgaca aggctgctag gaagattaca
|
43861ttgagagtgc actggtgatt attcagcatg tcagggaggg cctaccactc cgggcctcca
|
43921cggagtggat ggctaagatc ccctgactcc cagtgcacac tcctcacaca tggctgcacc
|
43981tctttcggcc tcaggggcca gcgaggagcc taccgacaag gtgaggtgaa gagcgaagag
|
44041aatcagtgat ggaaatggaa gccagcagtc agggcttgca agctcagccc ttctcaggtc
|
44101ctccaagaag taaatcagct gagggtcaga ccccaaggag cttcacggcc agcaactcag
|
44161cctggtttcc tctcttttcc tcgcatcaca ttcagtgacc tatcagtcta gatagagggt
|
44221gctttttcaa ataaaccctt ttccaacttg tctaggagaa caatcataga ttttgatccc
|
44281aaagttaaat tggcctgtca gatacaaagc tttctggagc cagccagcat ctcaggatat
|
44341cccacactcc tcccaaatgc attaccaccc agcaggtagt gtcatcgcag tttctctggt
|
44401ttcagaataa taactggtgg gaaatgccca tggaattgac actcagcact ttgaagattt
|
44461tatcagttgg gtaaatatca cccagaagac aggagaaact ggggttctgt tacgacatct
|
44521acaactagaa ggagtgctga tcacttcttt tccccataag gtctaggatc ctataaccac
|
44581gacaggatca gaggcaacct ggtggtgaaa ggtagacaaa cccaaactcc ttacatgccc
|
44641agttcagctg tcctcacaat catcctacac atcacatgca tcctgctcaa gagctcgtgg
|
44701ccagcctcct ccttcctaca gtgccctaat gccctagtga atcaagcccc accacagtgt
|
44761ggacgctcgt aacatacctg tgactccccc cagcagcctg ggatcttcct tccactccat
|
44821tcacgctcat ctctgctcgg gctccaagcc tcctgggccc attcacacct ctgagcYttt
|
44881gctcaggtat ttcccactct tgctctcagt ggtctgcctt ctatttgtct accccaactc
|
44941tatgcctctt tctatacttc ccccgctact ccaacctgca ctggtccctt tcctgagcct
|
45001aactggcact cacattttgc accaagttgg cacttaattt taaatggtct tgtcttgaat
|
45061aatatgctaa ccacctcttt cacctcctcc agaacagaaa aggtgcctta cacagtggag
|
45121aagSctttag agccagaaaa atccttgatt ggaaaaatca gactttacca gcaatcacca
|
45181ctgcctttgt caactcaatc tctctgagcc tcagtttcca tctctgtaaa atacgaattg
|
45241taatcttaat ctcaaagggc tgttatatgg ctttaacaag ttaatatcta taaaaagcct
|
45301agactcagta actaatgcat agaaagtaac ccccaaaagg ttattccagt tcccctttgt
|
45361ttcttttatg tcttgcagaa cctagcacat tatggcaaca caagacattt ggtatatgtt
|
45421tgattcattt ataagtagta taaagaaaac cagtaactgg agggtcatta tacaaagtag
|
45481cagcatgcgg tcaaaacaca tggatctatt tttcaattac ggacaaaaag ttgagatcta
|
45541tggagggtaa aacagtctac tttaactaaa gaagttttca ggattacaaa ctgccagtct
|
45601ctctgtactc atcactcagc caagcagaag tttcagcaca aatgttcatg ctggcaattc
|
45661atactacatt ctttcttaca taagttgtct ccatccccaa actccataat atgtatggtc
|
45721cacagaaagt tcacttcacg tgctaaatgt ggtacaatcc ttgctacttc tttaaatcaa
|
45781acacagagca aaatttttct ggagttcttt ttaaaattat ttagaaagaa Ygccgatcac
|
45841ttcttttctg aagcagaatt tttgtcattt atctatatat gtaacatata taaatataat
|
45901tgtatatata attaaattcg tcttctaata agacctttcc tccccagatt ggagacaaca
|
45961tagtagacaa ccatgaatat tagtgaggtc attcaaccaa aatcatgctg agaataatat
|
46021ccaagtcctR tgagcaatta tgaaatccat gcaccaaaga tgatgttgga tgtggtggtg
|
46081tccagtgaga tgaaaactgg agtggaattc agatggagtt tcagcagaac cattttcacc
|
46141tggtggcctt ttggccttac tgttcttaca gtttcttctc actgtctctt tttcacatac
|
46201ttggcatttc tctggaggaa aatgtgtctt gccactgcat tcacttttca gctcgtggct
|
46261catgctaccR aaacaatgga agtcaacaaa aggcttgaga cattgcttYa gtgtgaatat
|
46321aaacaagcct agaaatgtaa ttttagttag tgatcagaat acatatccgt gaaactaatc
|
46381ttctccacgt ctccccactt cctggtggtg agttaggcac caactcttcc aggtcatcta
|
46441gctataatgt aaaacattac agaactaaat ggggacccca agaggtcatc taacccatgc
|
46501ccccaactct atgcaagaga aatgcttggc tatcagtgag ttccScatca gcctcgacag
|
46561tctaaaatgc ttggtgtcaa aagaactgct tgtctatttg ttttaggcac caaggtgttt
|
46621ctcctgtgct ccctggagac caaatgtaac tggtcagtgc ctttatctca gtgatacaca
|
46681taacaacagc tattaagtga cccctaattc ttttccccaa gttaaacaac cccaaatcca
|
46741caaacctttc cttaaagggc ttattgttca tcctgttaaa catattgtta ataagctttt
|
46801ctgtactttt tggatttccc acagtctttt tccgctaatt caaacacagt ggtgtcaaat
|
46861attaaataga gctgaagcat tgcttcccag accttccaca tcattcctag tttaacgcag
|
46921cttggttatc atgctttctt aaaaataaac aacacaatac tcctccagct tgtgatccac
|
46981tacgacttcc agatctatct cagctataat tgtgccttgc caggtgatgg ccaataatac
|
47041aatcaacata atccagtcaa gcagattgat gctaaaccat tgatgaccac tgtcatcacc
|
47101tctcaaaaaa gtatttccta gtctggtgta aagaaagatc aggtaaccaa acgatgtgtg
|
47161tYgttcacac aatgtttaat aaaatacaaa gcatagcatt ttctaacttt tagtttgaag
|
47221actctttctc ctcctggtct atgcctgaaa actaacttct gggtgaYttc atatgtgatc
|
47281acagggtaga acttggagaa aatgaaacag atatttaacc tgcttatccc aaacactgcc
|
47341ccttttcagg aaacttggag gtaactgggg taacttagca ataaaccccg ctgaaagtta
|
47401tcctgaggtc tgaaagtcac tgatcctctc agcacaatgg agtatccact aacaatggct
|
47461aaagagcatc tcttcaataa acttagcttg actactacca cctatcatga ctagctcatc
|
47521gaccaccctt caggatcatt tcatgtgcaa ctagtaagaa ggtttcaatt cagtagtagg
|
47581tctggcatca gtaatcttct ccaccatcca aggaagaaca tgttatctta ctggttgttt
|
47641tgggaggtga agtaagaagt tgggaaagtg tgattctgaa tatgaagaat ctgagtactt
|
47701aggaagaaat atatctcagc aacatcctca acattccata attaaccact ttaaggagcc
|
47761acagccatta aagaatctgt gctgacccca aagagaccat ttctctaatg gcaacaactc
|
47821cacatctccc aagttgggcc ccactcattg tctcctatca tttgtctcat acagatgaaa
|
47881ctctaccatc tatgttcact taactcataa gacccaagtt gctagagatg aataatatta
|
47941gtcatgatgt ccacaatgga gagtcgctgt tatgcattgc tggattattc atagacactt
|
48001ctggtaaaca tggcactact gcagtttgga ctctgtacca aaactagaaa aactagtaaa
|
48061cagctttcca aaatcttgtg gtgagatttt tctggctgtg aaacatttgt tgcatttggc
|
48121catgaaatag tttacagtac tgatcatgaa atgcatcagt agcctttcac ctggtaatgt
|
48181gaaattctct ttccatagtc ctgaagctta gaaaatgccc tattaccacc accaccacca
|
48241cccccaactg agcagtgcaa tactctcatt tctaaattag ggatcagcaa actatgtctt
|
48301gtgggccaaa tctggccaac tgcttatttt tgtaaataaa gttttattgg aacacagcca
|
48361tgcccattcc tgtacatatc ctctacagct gttttcatgc ttcacccaga gctgagtagt
|
48421tgtgacagat gtttgcctta caaagcctta aatatttact atctggtgtg ttacaggaga
|
48481aatttgctga tccccattat aaatgataag gcaaaaaaat ttcttattca gaataacctc
|
48541ctctccaacc caacaaaaga aaacaaaacc agaaaacaac catgacccca gcgagtagtg
|
48601ttcgcatact taaaagccag cctaactctc ttacaaagta tactctgaaa taagatgcat
|
48661acaaaacata aaatactatt tgatggcaca gtagggtgac tgtagtcagt ggtagcttaa
|
48721ctgaatattt taaaataatg taaagagtgt aatcagattg ttcataactc aagggataaa
|
48781tgcttaaggg gccggatacc ccattcttta tgagtgctta tgttcacatt gcatgcctgt
|
48841atcgaaacat ctcatgtacc ccataaatat ctacatctac tatgtatcca caaaaaattt
|
48901aaaaaatttg taaaagtcta tatataaaat acttacaagg ttaatttaaa ttaaaattcc
|
48961ggaaggattt ttttaatgaa aggaagttct gaaactgatg atttagggat ataataaaac
|
49021tcaaatatgg ttctagttac atggagtgat ttgggtttct tagaaaagaa gggtaaRagg
|
49081aatgtgatgt aatagacaac tggtcatcaa taagaataaa ctgaattttt taaaaaatct
|
49141ctaaactgta caactctacc cagagttcta aagagaaggt cttccaggta catgcagagg
|
49201aaaaagaaat ggatagggga atgttttctg gtggagccat atcttgaatc atccctaaca
|
49261tgtgctgaat aatgacctag ctccatccag agaccaaccc agggacccat tcccaccaca
|
49321taacaatcct aagtcaggat actgctagag gcatccatag attaaggcaa agatccRctg
|
49381ttatgagaat ctgaacaagg catgccaacc tcaacttcca ccttacccag actggcagcc
|
49441cttgggaaaa gctgccccaa agccatctaa gtgtgcccag taggcacatg gtcatgttca
|
49501gttagggcac tcaaagctga tcttcagttt tcatttttca tttatcacca acactgaaaa
|
49561atggggagat ctcatcaaaa tgtttgaatt gtgacctccc ttgaaaaaaa aaaagatctg
|
49621ggaaccctgg gcccacctcc tgcaggctgc atcccctgag ctgagtcacg gctgccccat
|
49681tggaagcaca ggtgcttcct ggtttgagac actccctacc actcctgttg tctccctgtg
|
49741acctgagact gagcctcaag ggctgttcca catctctctg gcattgtcat ttatgtcaca
|
49801cctgccctgc ttcattcacc aaagatacct gctctgtcag catcggattg gcaaccccag
|
49861agctaaccat ctatggtaac tacatgtttc cgagtggatg aggaacatga tttctttctc
|
49921tctttttcat tctctggccc atgtgtgtac ttttgccctc cctcttggtc agtgaccatc
|
49981tatagacaga aagcacatca ttcttggcct acaacccatt atcagacacg tgaaaaagtc
|
50041agtccctgtc ctcatggccc actattatgg acatttgatc atcctggatc tcctctatcc
|
50101ttagttattt acatggatag tacacSttca tgccagacct ctcatccctg tgagcagccc
|
50161aaagatagta tatgcaaaga aagcccgagt catgaggaaa gacacactct aggtagaaag
|
50221cactggccca tcagaatcaa ggtcctcttt tctagagagt aaattagagg gtgcaatcgc
|
50281ttcccatgga agaagatatt ttattcctta ggtgacttct taattgaacc taatgtctca
|
50341aattttgagt cactatagga agtgggtgat gtgtaataaa tatgKgaaac ttcattttac
|
50401tcWgtgttca tcaaaagata cRtggataag ctaaatgcgg tttacacatg caatgaaata
|
50461ctatttagcc ttcaaaagta gggaaagttt gacacatcta cgtaaataat ccttgaagat
|
50521attacactaa atgaaataag tccgtgacaa aaggacaaat gctgtatgat tccatttata
|
50581caaggtactt agaggagtca aattcagagg gacagaaagt agaatggtgg ttgccaggag
|
50641ctggggaggg aatggggagt acgtgtttaa atggtacaga gtttcagttg gagaagatga
|
50701aaaaatccta gagatggatg gtgatgatgg ttgcacgaca atgtaaatgt acttaatgac
|
50761acagaactat atcttaaaag cggttagaaa ggcaaatttt atgtaatgca tatttcatca
|
50821caataaaaag gaaaaaaaaa accctaagga gggcaccata ctggtgtggg gctttctttt
|
50881tactgctagg aaWacttaca aagtccataa tgcaaggcat aacgtgatat tcagtctaaa
|
50941gaaagatgga gtacactagc agcagcatta cagtgtcatg ttcatctcca cttggcccca
|
51001ctgggggcca gcaatgctca aaggtcaaga cctggcctga catgctcacc tggttctgtc
|
51061tgacctagag gacccctcag ataagagggc ccatcttcac acacaaggaa agcctacccc
|
51121gggggttcca gctgacagct gcaccaaccg gcagcttggg aggctacacc aacagcacct
|
51181tccaggcaat gaaaatttta acctcccacc tattctaagc acacattaaa tcttgcattt
|
51241ttgtgcaaaa cttctattct tggcacaggt gtgacagcaa ccttggacag gtatactaag
|
51301tcggttcaca taatcaggct ttcaatccat caattttggc catggagagg gtgatgatgg
|
51361tgatggtgat ggtgatgggg gagtgggtga cagcaaccct ggctcagaga atgaacgctg
|
51421gcaccaaccc tgggcattgt tcactttcca ggccaccatc tgtcagccaa gccagtggca
|
51481actgctgttc tagaccatgc ttgtaaataa aacaacaagg ttcaacaaat cttggcatgg
|
51541aagtgggaag aatcatctca ggagtccctg ccgcatgacg gcgtgaaagt gaactcacac
|
51601aggatgagct tggttggtca agcaaatttt acagagatgc tataggagca ttggaaacag
|
51661actttttatt taacagaaac ttacacacac ttggtacaaa ccctacatta tgcaaacctt
|
51721tatcacagtt ctacacaggt tgtcacttgt gggagttggt tggaaagcag attattatga
|
51781taattattag cattttgaca agggacattt tctaccagaa aacgtcagag aaaagggcta
|
51841caaaatgata cagacactct cggtgatccc ctccaccaac aggactggct ttgaacagga
|
51901aacctgaaag gactggcagg aagtcggtgc ccacctgccc tgccctttca gaggccaaag
|
51961agattctcag gctcagaacc atttcagtaa cactgtgact caaggacctc tgctgaccag
|
52021aatacccagc Sttagactat tcgtgtgtta ttatgactct gcttacaagg gagggaaacc
|
52081caagagcatg gctgtgtgaa agcccagtgc agtggggagc ctgcgggtag aacccagtgg
|
52141ctcagccagt cagccctgca cctttgctgg gccacagaca cagcgccgag atacatccca
|
52201tcggccaaaa cgcccacttc cgccagctca gccagaaagg gccaYgttag aacacccgcc
|
52261gtcttccttg gctcccacca gcaactgaat ttgaggttct catccttcag gtcggccttc
|
52321ctagcccttg gggacagctc tggaagctca ggccccagaa gccagctcag cagaaggttc
|
52381cctttcctca tctcttctag gagttgttag gtgactgaac taatatcacc tcagctgatg
|
52441cttttatttt tgcttttttt tttttttttt ttttgctgca ttattttaaa caaagctctc
|
52501tgtgttcgaa tctattgaac ttgaggggat atattccatc aatagatgga attccttcct
|
52561gagctagacc tcatcagaca tgataactag gagNcaggct gcttctgaca ttcagataaa
|
52621aggggcttgc ctggggtgag ggggcaatga gggtggggga aactgctgat ttgtggctaa
|
52681gttatttcag tcaaatctta acacacaatc atttaacatc accaacactt tcaatagact
|
52741tttgaaggag gaaaaaaaaa ctgagcactc ctcacttacc acatccaact cgcagaaata
|
52801aaaataccta aagcacatac atgaatggct ttttaaaaag cctgagagag cagagttgat
|
52861ctttattttc ttaYttaaaa tgtggggcat ttttctttag agttaatatg cagtctttta
|
52921ttttacatta agtactctta tgatttcatg tcttcacaaa attgcgctta acttttgaag
|
52981taggaggtac tttaaacaaa aatactgtgc Matgtcagca cttttttcct tttaaatatt
|
53041gaaataaata aaatagttaa ctcttttttt ccatcagttt gtttgtgttc agttatttct
|
53101actgtagagt aattccaggc ggacctgggt actttctcac agacaatcaa agaaaatata
|
53161atgaagattt aaaaagaaaa aaaaaatctt cttattgcac aaactgaggc cattcccaag
|
53221gcttctgtgg gctgagctga gttgcgctgc aggattttcc actcctgtgc tggctcctgt
|
53281gttgtctgaa acacacgcac aggagggggc tgggcaaggg aagaggaaga agaggaggag
|
53341gaggaggagg tgccaatcat cctggcttct tttcaccttc ttcggaaatg gcttgcttga
|
53401aggatgctgg agtccccagg tcataatgtt gactgcagag ggaaaggcaa tgaaagataa
|
53461aacaaaaaac aacagcatgg aacaactact taaaaaagaa agatgaaaat taaggggtga
|
53521cagaaatgaa atgaattaaa aaaaaaaaag aagaagaaag aaagaaaacc accaactaat
|
53581tgccaagtta atgaggctag gccaggtgca acaaaaatca gggtagtgtg tccagcgcct
|
53641tgaacttcag cagcaWgaga tSagccagga atagggcagg tcagttgcta ctgggccaga
|
53701ggcagagaga Rcacagctgg atggtcaatt cccaggtggt gtagcaggca gaactgggtg
|
53761ttagcaaaaa aaaaaaaaaa aaattcccct ccacttaRaa accaaacaaa ctgaatcttt
|
53821tcacagttaa aacaccccaR aaaggacctt tatgatgtca tctctctccc tgYcatccaa
|
53881gtaRaaatga gtagttctat ggtatagaac caattcagcc acagaaaacc ccatcaRatg
|
53941cctcatttgg cctaagccca aaaggacact gcttccttca caagcactca cactcagccc
|
54001caaccctgcc ccaagtgatt caagtgtgtc aRagttactc ggagacagtc cccaaccaag
|
54061agaccagttc cagtcctcta ctagcacagt gatccctttg tcagccttgg aacctggtgg
|
54121tggttcacac aggtgggccc ttttgcctgg atagccacgc atagcttttg cttctagctg
|
54181aaatgaaatc tgccattttg gtctttggaa cggagtagtt gacacaaagg agtgagcaat
|
54241gaaaccaagt actgccacat ttcaccccgg aagcagtttc tgaaagcaga gatgggtgtc
|
54301ccaacagtgc ctagatcaca ttaagctgag cgataaggga gggagaagag gSagaatggg
|
54361cctaaatgga aaatggccaa gccagcaagg aaaaaagctc aaaagcaaat gagcagctca
|
54421gcctcttcca agttgaaagg cccctcccct gccccacctc tcctggtacc caagcatcac
|
54481tcaatggcca ggtgcacagg cctggattag atgctcttcc aaagctgaga ctccattcat
|
54541ccaactttcc tccttgacca agtcctccct ccacacctgc tcctgttcct tgcctctacc
|
54601ccatcccacc ccactgtctc cctttctgat ccgctttgct ggtgcaccct acccccactt
|
54661ccctcatgct ctttgctgtc accacctgcc tctagctcct tcccttgact gatcaaaccc
|
54721aggtgacctt tcctgggacc tcccacagaa cgcctgccga ttgttctctc catgggcatc
|
54781tgtcatcatt tcactccctg ccaggagtct ttctgtccct ctcccagtgc cctgacccct
|
54841ctggtcagat gttacctgcc actctgtagt gagtctgtct cataagctta ccccacacct
|
54901ttcagtttct tcaaatttcc accccgacct cccaacacac acacacatgt atttttcctt
|
54961tgccccacta aagccaccta gaaaatcatg cgtgagtccc aacttggcac tcctaacttc
|
55021cattttctct tttgtttcct ctggtcaggt caactgcagg ccacaaaaat gaaacaatgt
|
55081gcagctgtgt tcttagtctc ctgctctcaa tcccctgcaa gaaggcatag ttttctaccc
|
55141ctccacacac atggtcaacc cctccccacc cctgtcctga catccccctt ttctctcctt
|
55201tacccctcac caccacctca ccacctccca cctgccccct ctgacttaac cactggatgc
|
55261tgtgtccaga gacttctcca ttctttctgt caacaatatt tattaagcat cctctatgca
|
55321tagagtgaga tttggtaaga cttccactaa ttatctcaga aactgctcag ttctcagttt
|
55381atttcaacaa ataattatgg cacactggtg tcaggcactg tctggaggaY atgagtgata
|
55441tcacctttgc cctcaaggaa cacgccatct gtttgagaag gactacaagc aaacatgatg
|
55501tgttgtgata agcacaggag cggcaggaac aaaatgctat ggaatggtac ttaggcgggt
|
55561tttcaaatgg tgatttttgc cattttacat gggttaggtt gtgattccca gctttgcttt
|
55621ttgttcgaat attatctcca ttgtctctga caatagacat tcttgcctac agattcaaca
|
55681gcaacggtcc atctggagct ctttgttgat ctagatggct tcctccaaga aaatcttctt
|
55741gtctactgag atccatggca aaaataatca catactaccc catgacagct cttacatgat
|
55801tttaactatt tgtgaatttc tagtctgatc cactaggtca caaaataaat ccaatggcca
|
55861ataaattcat tgccccatgt ttaattttat cctatccttg acagtgctga gcagtcacaY
|
55921gcatactgtt attactcagt ccctagttgc caaatgaacc gaggtatatc tgaatgaaaa
|
55981tgttatcatc caaggtctgt aaacagaata gcctgaaatc tcagctgaaa ggccaaatgt
|
56041ctgagtcacc agtaatgggg taaatcaatc acatacctcc Kgatgtaatg cactgagaag
|
56101gatacaacat catttctaag gtattctaac caaaatgcac aacttcagtt tagtcattag
|
56161aaaaacagca tccaagcctg aactgaatgg cttttgctat gaaatgacta accagtatcg
|
56221aggttgWgaa aaacaagatt gtagtactaa ctattccaga ttaaaggact tgtaagagga
|
56281catggcaacc tgtgagccca gactggatcc tggaccagaa aaaggacact agtgagacaa
|
56341ctggcagaat ttgcataagg tctgtaggtt atagcattgc atcgatgtga atttcctgat
|
56401tgtgatcatt gtactgtggt tatttgaaga atctgggtga aggacatatg ggaattcttg
|
56461gtaaaatctt tgtaagtttt ttgtaagtgt aaattatttc agaagtaaat tttttaaaaa
|
56521gccatagtta ttggttgagt tccagtggtg agatactttg aaaacctaat tgccaatgtt
|
56581ttttatctaa taattcagtt ctgacaggaa tcttccatca ttcccattta ttttgtaaac
|
56641caatcatgca gaatggcttt tcctatattg ctattttgaa taggtgatca gaaatcactt
|
56701ttattaaaca ccacaatatt atataattca atgtttttgt gttagaagca attgggtttg
|
56761tgaccagggc ccaaaatgtt cactccctgc caccattact cccgctacca ctggcaccac
|
56821aaaaacagtg accatttagg aagctcaact ttagttctcc cagaaagttc atgaggactt
|
56881agacattgct acttctcaga aagattctaa tgtgtcatag tttcatttgg ggtttctgtt
|
56941gtttcagttt tttcttttac agaatcaaat acctcctttt catccaataa attcttgaat
|
57001aaaagaccta caggcatttt actgatttca ctcaagaaat cttccaaaga tgatctttgg
|
57061ggaagtcagt atagacttag gaaagattat tagaagatcc atacatcatt tactgagcct
|
57121ggaactttag acaagtcatc aaacaggatc aaatctcagt ttcctcatca gtaaaacggg
|
57181aataaataac atctacccta cctcatagag ttaagcatca tcatgaaata atataagcta
|
57241catattctaa tagggaaaga aatgtccatt tcctctctca gaaactgagg cagagatccc
|
57301tgtcaacaaa ttcacacagg gagctgagcc cagagcccag aacttgtcaW ctccactcta
|
57361ggcttccaca caccagatca aagacacctc actcagaaaa tacacaacac aagtcacttc
|
57421tcctccaaag gctgagcaaa atcccctgag gaaaaattcc taacagatga gtctgctcca
|
57481attttaagta caYgttcaag atcatattca tcagatgtaa caggaggtat actgggataa
|
57541aattaattaa ttttattcca ccatgaggtg agaaccccca aacacccttt agttctctcc
|
57601ctgagtaatg atcttgcatt ccctccagtg ctgtataaag cagtatcagt ctgtagccca
|
57661ttagatgcag agagagatgc aSagtaagca ggaaccctta aagggatgct attgatgtga
|
57721acatcacatt tttttttatt aaattcttct ctctaaaata ccggtagcaa attggattac
|
57781tgtctttata gtacctctaa aaaattaaat gcatatttct aattcccagg gtcatagtga
|
57841ttatagtgtc tgatctttac atagtctctc agtaacagaa ataaaggatt tgattgttct
|
57901aggtagggaa aaaaatcagc tagaccataa caattgtcac ctttaggtca acagcccccc
|
57961tccccagggg attaaaatgt tgtaacaaat ttagaaagtt ctatatcttt ggttcccctc
|
58021tctttggcct gggactcaga aaactcaggg tggtacttta ctgagctgag ggcaaaggaa
|
58081gctggccaga tYgttttcat cttgatgact ctaatttctt ttgtatttta aattttgagt
|
58141agtgatactt atttaacaaa agcaacaaca gaaaggtgtg ttgactgttc acacagctcc
|
58201tacaattcct aaggtcacaa aaaaggtgat ctctttgtac attgtctaga agtgatgatt
|
58261aagaaggtaa gttatctaca atattccgca gagaatctga attagaactc tcttttacag
|
58321gatctaattg cttactcttc cgttgttgaa atttctttta atgacgttac cttttaaaag
|
58381ctatattcat tacaaaaacc cttttcttca gttggaattg agaaacagca aagtatgtat
|
58441acatgcatgc atatatattc cttaattata gactatgcaa ggggcaatgc aggcaacgat
|
58501agagtatagg ctctacaatc aggttgccag ggatcaaaac ctggctcctt cctaggtgta
|
58561catttcttaa ccttattact aacctcagtt tccgcaaact ggggattaat ataaacacct
|
58621atctcatggg agtagtcatg aggattaagt gaaatattcc aaggaaagcg cccagaataa
|
58681tgcctcacac aaaaatgtag atgactgcta tctagaaaaa gggagataaa Katatcacat
|
58741ccaccactaa agtggttgga aaccaaggac agccagcttc ctcatccgac accttctctc
|
58801tcggagcttc cttcctttgc cttaaWacat ttccctccaa tgcaatgccc atcccagtcc
|
58861ctccaactta actcacttaa cctctctggg tcaacttttc tcaactgaaa agtgaaagat
|
58921ttgaacttga tcatcttaaa agtcccttcc agtttttaag ggtataaatc ttgagtccgt
|
58981tcaaagactc tataagcaag gtgagacaag atggtctggc catgctaaga aaccttacta
|
59041tgcttctatt accccaagga agaaaagtga ggatatcaac tacctccaag aagagaaact
|
59101gaagatcaaa tatcaagcta tactattaaa tataaaatag acaagcaata cccattctca
|
59161gataaacatt ctcctgggag tttgccttgt tagttctaaa tggttagttt ctctgttaga
|
59221ctccaagcta gactctgaaa ttaggtagcc ttttataatt tgctttaaat atgtggatta
|
59281aaaaaaaaaa cacctcaagt gtaaaggcaa attgtcattg agaattctgg gactatgagc
|
59341aactagacag aattcaaatg agagtgtaga ttggttgaac atatgtttat taacatagaa
|
59401gctcacattt tatcaatgaa agcaagttgt aatcccatga atccaatatc tgagtcaaag
|
59461gtacagagta aagaggtgga aaatgacagc aagtgtacat tgtatccccg tagcagaaac
|
59521ctactggaac aaactctatt ggctgacgtg tgagcatgca gaatatgaca accttggagg
|
59581tttatgccat atttcctagg aacaggccac atatagatta gacagaacaa cccaaaagtg
|
59641gttgggattg ttactttcat tccctcaaaa ctgagaataa atgcccaggc gatcacatac
|
59701acatctcaag catgagaaaa gtggaagccc tttctgtctc aggctaccag gaaagcacaa
|
59761aggtctcatt tctgggtttc ttggcttgtc cttgtgtttt aggttggttt gttattttaa
|
59821ggagcggtct aattcatgag gatctgcagg ggctggactg tcaaagtaga tcttcccaga
|
59881gacactgata agcagtctgt taaccaggca gctacttggg tctcccaacc catgtcaaat
|
59941ggttctgcct gtgtttccag aactgtgcac tcctggaggc aagagaccct ggccaacctt
|
60001aaagggagtg cagaatcttc caaacagcca agttgagttt tgtgcctaat cagggatctt
|
60061ctttaatttg gactcatccc cttggttttg aaattggtac cgagagtaag aaataccacc
|
60121tagacatgca gtgccctgtg gccacaacct ccctattcct acccaaatcc agcagccaac
|
60181tccaacttca gttccctgga tttcacttcc aggtttagcc aagggaggca gagttagcca
|
60241agcacttccc cagccatttt ctcttgtagt tgaagccaga agcctgccat tctccacact
|
60301gagcccctcc catagtccaa gcaagactca gatcacacac ctatgccagg gcccacatga
|
60361gttcacatgc acacacaggc cacagagggc cagggggaga cactccagca gccactctta
|
60421cactaagaag ggagtccaaa cccaggaaaa caaaaaagca agctggggga aaaaggaaaa
|
60481agaaaaagaa aactaaaaaa tagatatgat ggttttgccc acattgcaag acaggttagc
|
60541caagacatac cttttgacta ggacctcgca gccggtcatt cttgggactg tcagtgaggt
|
60601gggtggcctt ctccatcgcc ccaggggcct tgagcagtgt tgctttggtt tatttcagga
|
60661agtgctattg gaaacataaa acaaagtgcc tggcaggcac tataaaaaaa aatagaagaa
|
60721atacggtagc cttgatcatc caatgggtat tgatacgttt cttaacaggg gcaaggggag
|
60781gggaaacaca cgatgatgtc tccttctatc ttccagaagc acggcctcgg cctcgggtgg
|
60841tggagtcact gctgagccca tgacgttctg cttatattcc atccctgcat ttggaagtcg
|
60901ttctttgcca ggaggRaagt gaggaaaaac cagcaataac aaaacagcag ctctactgac
|
60961ggaggaggag gagcccagga ggcggctggt cagggcccag gtgtggaggg aggccaggca
|
61021taggcacccc gacttctctg gaactactga cattttctcg caagcagaga ggaagatgga
|
61081aaggtcaggg aggagaatga gggaggggtc tgccgcgggg agccgcaaac tccgtggggc
|
61141acagaatagt gcaaccgtct cccattgagg aaattctccc caccgggcgg cttgcctcta
|
61201aacaggatat tgcttcgatt tctttgattt cccttctctc tctctctctc tctctctcgc
|
61261aaaaaaagtc tgattctaat aacagctaga atatataaat aataatgttt taatgttatt
|
61321ggttctttgt ttccaaccca aagttcctct tctcttcctt ttgccaataa atatgaaaat
|
61381tgaggacatc aactctgctc ctgtcaaaaa gaccccctcc cctcagaaaa gagacaatcc
|
61441gtctaacttc ctatttctat ggaaaataaa tagcgcatca cgatgccatc tctcggaaga
|
61501acgctcattc tgctgttttg ttttgtttca gtagtttgtg cttctgttgt acatacccaa
|
61561aacagagggg tggggggagg gatggaggga cacgtgggag gtgaagggaa aaaaagcaag
|
61621gatagaggga aaatctaaag ttgcctttca ttaaaaaaaa tatatatcag aaccagcaca
|
61681atgaccaaag tcagaggggg atggctaatt gcccagagag tctgttccgt gggtttagca
|
61741actgcccttt ttatctgctg tgggcgaacc ccggccactg cggcgtcctc gacaggagcg
|
61801aggctcttcc aaatcgtcct catcaaagcc gtggaaagtt gacgtgtcac tttctgacgt
|
61861ggaaccgaat aagtcctccg tggtacgtgc tgcggccgct gcctccttct ccttcctgcc
|
61921ttctcctccc aaatgagctg acatgtatga tgaatatatc agcacatggg ttaagcaaca
|
61981gacagcatta ttaatattct cattacatta ttacaatgct attcttaata gcaagatata
|
62041aaaccaYttg cacaccaaag ggattaaccc ggtgcatcaM ctggtgacgg ggatttggga
|
62101caaagcaaac atttccaggg aagaggcttc ccccactccc cgaaaaggca tcatctctac
|
62161catagtacat atgtccacag cttccgacag caaaagattc aaccatgatc tttcttctgt
|
62221tgtgcataca cacaggcgct tgcacgctca ctcaaccctg ccccagacaa tgattttcat
|
62281tggtggtttt taagcctggt tgggatttct ttggtgtttt ctgttggtgt ttctttgaac
|
62341aatgtttgtc cttcactttg acagtcagct gtacaaaggt attactgtca gataacccat
|
62401tcaaggtggt taagcctcca tctatttcat ttttatttta cccgcttcta atcccattct
|
62461ttcagaaccc tttcaattct ccccttacgc catgtcgttc atttgcactg aaagcaaaag
|
62521gaagttggaa agtctgataa gtggtaggtg ataaaatagt ttgtttcctt taaccacagg
|
62581aggaaatttc tgtgatctgc atccacatac atgtgcacgt gtgcacacca cacacacaca
|
62641cacacacaca cacacacaga cacaSacaca cacacacaca cacccagcca ccagccatgc
|
62701ccaggtatcg gttactccag aaagttcagt tgtcaaatct cattcagggc actacaaagg
|
62761tgagaaatag gagtagaaaa gccctaataa atcagagcat cctgaaatYt gtaaaactca
|
62821ggtttaaact tttttgcatt ctaaatgagc cccaggactg ctcttgtata aaggaatgat
|
62881acatccctca tggtgccaat ttcaggaacc tcactttctc ccaggaaaca gcagtggtag
|
62941ggtagatggg aggggaagga agctcttcca agctccatac tcttctctgg aaggaccgta
|
63001gggaggctcc agagaagtat tcgcccacct gccttaacaa gcacatctca tctcatgggc
|
63061caatgacacc tgtttcttcc catggtatca actatttcag gaacattaga gtcagacctt
|
63121gactaaatca tctaccaaaa ccaatccttg gcaaatgcag tgagaatacc taggctggta
|
63181gaaaatggct ccctgagcca catagcagac agaaccttgg agggaaagct gagggaaggt
|
63241tgtggaaaga ggctttgcat agaaaaaaac aacttcccac tcctgacatc ccatggcttc
|
63301gattctagca cccctctttt gtaagaaagg aaggggagaa attacagcag tttgcaatga
|
63361gaattctgaa gctgccccct ctaacccatc caaacctaca gcagtccata acgtgttgct
|
63421tagaccatca cttcaagtga ccttgcttct ggaagtagag atttcatctg attgcttgct
|
63481tttaaaaaaa cactgcattg aatttcatct gtttttttta agtatcttaa aaaaacagag
|
63541tccgctatca caagggccct gtcttctacg ctagcatcca tagaataaaa aattcaatgt
|
63601taggtaccat gtttggaaag taaatgaaYt gacagaattg cacaaatgga ccacccttga
|
63661gagtcacacg ttgagggttg tgtgcagcag aaaccacagt ccttttaaaa ttactgattt
|
63721gctactcaag ccagccttaa gccctaaaca gccctaccat caaaatataa aagggctaaa
|
63781gctaaggttt gcagacagag caaggaaaga gctgagttgc tacagtcaac catgatgggg
|
63841tcatctcagt tcttctctgg ggactgggag tgaaaaagac actggataga aaggtagaaa
|
63901ggagaaatga ctcctcattg ctggaacaaa gcatccaacc aaactgtttc acctactcat
|
63961atcaggggct gatgagacta aaaatggggt tgaaattccc tcctccctgc ctcacactgt
|
64021ggtctagtgc tgacataata caatatgaaa aataggtagt accaaccaac catggccagc
|
64081caaaaataat ggtttggtta gaactaaaaa acaaaacaac catttgaaca taacctgaag
|
64141acctgaattc attttaagaa tgaaggaaca agaccaaaag tctctttctg ttattttagt
|
64201ctttggatag gttaaaatat aaacatatac accaaatcaa ctgcagatta gccctaggaa
|
64261tgcctgtcct tttgcctcat tgatctatcg gggtctcttc tgttctgttt tagaaaatga
|
64321gattagtggc caatggcggt ggtgtttatg cagctagcca ggagcccggg gatctctgac
|
64381tcccacaatt caagatgtgg ttgctctccg aatactcatg tttccacacc acaccacact
|
64441cttcgggttt gccctaggca cttccacaga acaaactcat ctttctgtta catgtgcatc
|
64501atccactaca agaaagcacg ttgccttctc tccaggtttt tccactctac ctcgctgtgg
|
64561tccgtaaaaa cacgcacaaa gaaatatgca cctcatggaa aggccagaca caaacccaaa
|
64621acttctcttt gccctttccc ccggatccta gggcataact tttggttctt gagacccaaa
|
64681gaagaaaaat atcagaatga gctgaaaact cctctccact cgaaagcatt gccaccatcg
|
64741cttccctctc cagtctccag caccacaaga tggaagagga atgcaagagg agcattcctg
|
64801gtctacgggc acccggtgtg ggaaggggcc acactcacca gagcgtccac agtctgcgca
|
64861ggacaccagc tcttcaggcc gcccactctt cttgttcatg ttggagcccc ccaagcagaa
|
64921gtcacagtag ttattgggaa tgactgttcc atccggtcct ttctgggctg tgggaacatt
|
64981taaaacattc caatttcagg cttacatgag tttcaactgc cccttcttct cctcctacag
|
65041tgtggtagaa tctgctccag aaggaatctg aggttttatt ataaccaagt tggcaaattg
|
65101ggctacgctt tcttttggat ccttccgggt ttaatggtac taataatatc ttgcaagtca
|
65161cccagagttt aatttttaga gtattcccca gctctgtgtt gttgcagaaa tcaccctgct
|
65221cctctgattg catccttaga tgatcaaacc atccagaaga ggtactggtc aagtgaacta
|
65281ctctcagccc taaacaatca gccctgtggg cccaggcccc aggcatcaga tggaaaccac
|
65341acaccatggt gtgaggacag ggagaggaaa gagccagtgc ctggaccttg ccattgggaa
|
65401cagtgctctt gtttaggaga tattcttcct gYccctgaaa tggaaaacaa agaagcactg
|
65461atgggaggtc atttccagga ataacaccaa agatgctctt ggggacttgg acaaacaact
|
65521tggtggagta tcaatctccc tgaaggggag tctcatctcc ctgaagtcca gacccattga
|
65581tcatggaaaS tgcccaagac cccaagtgcc taaaatcaga actagaccca ggcttctagg
|
65641cacttggctc agcctcatgc cagagatgga ttaaacggtg agttactgag catgtcttta
|
65701ggcttaagac cgtcacgaat aactgaacac actaacttca aaacccactc ctgctggagg
|
65761tccttaaaca aaagcaaaga aaaatcttag gacatgactt tgaaaacaaa gcctgtgagg
|
65821agaatagcac ctgtccttat gcaccaaaat cattccattt ccaggggctg cttgaRaagc
|
65881cttgaacaga ttatttgcat ggagagaaat acttcccttt ttctgtttct ccctccctat
|
65941tgcgggcatt tctttgtcat attcacactc cctgtttgta actaagaaga aaagtctttc
|
66001tgtttatggg atcagcccta accacccaag tatcttcctc ctcaccagac ccagtgtctg
|
66061ctgctgcctt tcattattca ctggctaacg ttaatcaggg tcccatacgg tacaaatctg
|
66121aaaaaggaag cagagatgtg agcagaaata ccatccagac agtaagtgat aaacggattc
|
66181acccacttta atgtgattcc ctctggcctc cacttcctcc atgcctctgc tttgcctcca
|
66241ggaatagaaa acctacctgg ggaaggcgga agacaaaagc tagaggaatt tcattataga
|
66301gggttaatcc atttatcagt tgctatttgg attgtttaat tggtttctaa gtcattgatt
|
66361tccatcttca gggaggcaga caattctctg caagaagtgt tagctgtttg ggggacacag
|
66421aggagctggc cacattctgg ggtctgttca gtgtaggctt gtcttcatca gtccctggat
|
66481ctcaaacaca tttgcatggc atacagaatg cttttgcaaa taatctccaa aaagcagtat
|
66541atctgcaaat attttactct gcctataaat tttcattgcc caaatccaga agtaccagag
|
66601tccccttctc ccttctccct caattgccat cttagtcatt tttagaactc tcctaagaaa
|
66661atccaagcat ctctatgaag caaataaact cagggtttcc tcaacaagat atggatggaa
|
66721aactatcaaa tggtgaacag aaagaagaga tagggtatac taaatttagg ggctgagggt
|
66781aaaccaaagt taagtgtcat gattgatatg agctagatat aaaatgtgga gatgccagtt
|
66841gttacttagg tagcttcctg tatggaaggc aatcagagaa tcccatatat atcattcata
|
66901aaaacttaca gggggcctag tctcctcagc tgtctctctc ctatactctt agggacttcc
|
66961tataattttc aatttcctcc ccattcacaa gatctttaag caactaaaga atctgatttt
|
67021ctccaacaca ctgtctccct catgacgtat gaggatgagt aagtaaaata tagagtataa
|
67081aagcttgcag attaattctt gatatggttt ggctgtgYcc ccacccaaat ctcatcttga
|
67141attgcagctc ccataatccc cacatgtcat gggagagact gagtaggata taattgaatc
|
67201atgggggcag gtttttccct agcagctctt gtgatagtga ataagtctca tggcatctga
|
67261tggttttaaa aggggcagtt cccctgcaca tgctctcttg cctgctgcca tgtaagatgt
|
67321gcctttgctc ctcctttgcc ttctgccRtg attgtgaggc ctccccagcc aggtggaact
|
67381gtgagtccat taaatctctt tgtctttata aatcacccaa tctcgggtgt ttcttcctag
|
67441cagatgaaaa tggactaata caattctaca cagcattcac taccaacaga ccattggtag
|
67501aacaccctat tgaatcagga actctaatac tacaagaaat aaaaaattag aaatgatcta
|
67561gtagagctaa gcaggcagtg atggaagaat tcagccttcg taaaaagacc aaaggaaaag
|
67621aattgaattc atctgaaaaa gggaagcttc tgacgagatg gagtctgagc agcatcctgt
|
67681tggccataca gagttcctgt ccaaggggtg agggaggtcc taaaatccca tgtataggcc
|
67741ccggtatgtg caggagtgac atgccaggcc agctggggtg tggaggtaca tttttagtct
|
67801ggcaatggcc cagtatagaa agtgatcatg cacagctgtt ttatttttca gagaaatcat
|
67861ttttgcttca gtttctactc tttcttacaa cagtgagctc aaagcatcct tccattgtgg
|
67921tcagatggtg tggaatggac taattgctta tgcacctgat tttcttaaac attttggtac
|
67981ttgggattag tttcagagca agggttctcc catggagctc tcccaaactt cagctaaaac
|
68041atatcagtca tgccctgggg agggtactgt tgatatcacc attatgaccc ttgtttatat
|
68101tgagtctgtg tgcctcctct ccccgtttca cattatcatc tctccatatt aaataggtct
|
68161actccttcag gttggagacc aggtctaacc cgttgttgga acccctacaa tctgtgggat
|
68221gagtgacttN agagagggat ggcagggatg ttagtgggtg gYacagtgat gccctgggag
|
68281caccggatat cattcactgc ccctggttta tttccctacc agaggagagc tggtccatgt
|
68341gtgcatgaat tggtctgtca cctggtctca tggccagctc ccagagtaca cagaagtcgg
|
68401tagccaatgg ccctgagtca ctggaagaat aatactgtac ccctcctgtg ggaggcgaga
|
68461catcattctg caccaaacac acaagaacat agaagacaat gattcattgt ctcttgagaa
|
68521gaggatacct ggtcatgcct atccactcag cttccctttt gttcaactgc gtattgaaag
|
68581gagaagaaaa ggaagcagac atttatcaca ccacaaaact gtggcaaatc ttttgctgga
|
68641tgctttatat atgttatttc attgattctt gcaaaaactt tgtgaagtag ggaatttttt
|
68701gacagatgca gtaactgaaa tccaaagaga ttaaagcgct ggctccaagc ctcggttggg
|
68761ctcttcgaag gcaggtttca cccccagttt gtctgtgtcc ccagagattg tgcctctaat
|
68821cacacttctc tgcctcctgg gaagtccaga ggtaaacact ttgcagccat accttgcata
|
68881taaaatattt cataaatctc tttagagtca aYctgattcg cccaatatga tatttacgaa
|
68941gcccaaagct ataaaaatta ttgagaccgg cctgataaaa gtggaaattc cctttgaact
|
69001taaatttaat gtccctacta cagtaatcca tcctgggtga tcctgtttat tgtcatctac
|
69061tctatgaaaa cacttctctg gagaattcca gaggctcatg aaggaatttt tttaagtaaa
|
69121gctcacatca tggctaggtt ggcctatggc ctgacccagc catgagcaat ttcctggtac
|
69181tgtatatgag atcattataa aaaagatttt actacaaata ggaagctcgc ccagaccttg
|
69241taagtgggat ttaaatagag attttgcttc tgcttatggg aaattgagtc ccgctttata
|
69301gaataagatg acggggaggg caaagacccg actggcatct ctatggcagc atctgcgatg
|
69361atggatgtgg ttttctgttg attaatgttc atgggctgag atcatataag agatacaagt
|
69421aagttgctga gaaaataaag tgagccttaa gagtttagaa atctacctga gggagataac
|
69481tctaaaaagc tcaaaggaaa aaaaatggaa atcaggaaca aagttcatga agaaagtaga
|
69541agaaaaataa cagaaggcag ggaagagcat tcagataaat caaagcaaga aaaatgaaaa
|
69601gtgaagcttc acacagcccc atcaccacgc tcagggaagc gagagcaggc attctggaaa
|
69661ggtatcagtg ctcgctacag gatttttgag ttaaatcagg ttttatgtct atggcaaaca
|
69721aggccccaaa tcttccataa aactaccgcc caggcagcac cgcctctccc cctcccagtc
|
69781ggatctccgc tgtggtgtRc ctgccactca cagaaagaat gactggcagg gacaaaccag
|
69841ccgtcggcaa cagccactcg tctgggttct gctgagacca gagctgcgtc ccaagcatcc
|
69901tagggaacag gaaactggcc agaagttcag gctcctcctt ggcacgtgca caaaagcatg
|
69961gcctcacatc ctgagcagac gctctgacca cctgccaggg cctggtgtgc acaaatgcgc
|
70021ggccacNctc ggtgcccacc acccaccacc cagccccagc cccagcccca gctgagcagc
|
70081tccatttctg gagcctgcta gcctgggaag ttggggtgca cagcccttgg ggaattcggg
|
70141ggcagtgagc agagccctct gggaagagat gcgcctctcc tcgcccctct cgtttgttcc
|
70201ccccgccacc ctccacaggc tgacagttcc cgtgtccctc tacaggtctg acatgtttcc
|
70261atggcaaccg gaatcctggg ctccggcagc ctccgctctt gccacctgtt atgacttcat
|
70321ctctcaagtg taaagcatgc tagccccgtg ccacttggct gtgcagagcg catcttcaga
|
70381ggacgacgga gggaaggaaa ggggagagga aaggagggaa agcagacagg cagcccaggc
|
70441cggccaggcg ggacgtgctg gctaggccag tccagaggag gaagcttggg ggccggagat
|
70501gagagggtgg ggagtaaggg tggaccccga cgtgccttcc ctgcagaatc aggagcaagc
|
70561ctcagctgga ggccactgcc acagcctgct acctcggcct agcctttaat gagggctgcg
|
70621ggaggaggga gaggcgggct ggggagacaa ggcgcctgcg aggagctccg gcaggcccag
|
70681cgtgaagcag agccaggaga gggttaaaag tggcgtgata gagactgtgg ggaaggctgg
|
70741accagagggc aaagggagca tcaaagccgg gataaatggc cttaattctc atgctcccac
|
70801tcgctggtcg tgtttactca tataaattat cccccaggcc tgacaccttt tttcactgct
|
70861tccctagaac tgatgaaaaa ataaatccca cagatcccag gaataaaaag tgtggggctt
|
70921tcattcaggc tggttctcct tggccactaa tagcaactca ggtcccgccc cagggctcca
|
70981ggaggaagac aaaggaaggc ttcatcccaa atgtggaggg gcagggggcc tggaagcctg
|
71041gcggggaagc agacagtagg gcccgctccc cacaggaccc tccaatcgtc agagccctcg
|
71101acggcagaga actcgctctc cccacaggcc atcttgccac cagctctgag gacaccgtga
|
71161atatatggga aagtaaaggg gactacgctg gagcggatgc ggaaggcgct gaggccaggg
|
71221ctgctgtcat gagtcctcac atttatggat ggggctgata aactgtcaca ctccgcaccg
|
71281tcaaggacaa ggtgagaaga tgagctggaa tggcagcaca tgccacagga gagctggaaa
|
71341ggcaggtggc taacaacgaa agccatggcc agagggcggg cttctctgga gaggcctctg
|
71401cacacaggga agggccccta ggcccggggt tttgactgcg ttgccgatct agaggcaaga
|
71461gaacacgcta ggtgatgtcc tgaggtccct ttcaggccta ttattcaagc attataatca
|
71521ggtgaagaaa gagacagaaa agccaagttt tccacaccca gaggaaccca gcctttcatc
|
71581actgttctat actcatgtaa atgcctcttt gcctgttacc catgtgctac ctgagggcac
|
71641atgagtaaca cctgagggca ggaaccatgt ccttcactgc ggtatccctg gcccctggcc
|
71701agcagtgagt gacacagagc tgacaatcaa tgctgagtga aaggatggac aaatcatcac
|
71761agaggctttt tgaggggaaa aaaaatctgc caggcaaagg gaagttaatg actaggaatt
|
71821gagtggacgg agagtccccc gagcacaggg tgaccatcct aagtccctct tatatcgggg
|
71881cacagaagaa gtgggaagga gaaatattgg agccccttgg agagaagaaa gctgtggtgt
|
71941ggaaagccac tgcatctacc tcccccagga atcctctctc ttaggcattt cttagtcaac
|
72001cagaatggaa ggcatcaaga atccccaggc tcagctggcc ccagagtctt gagactcatt
|
72061ctgtctctca ccagggactc agcaggagcc agtgagaaca gaggccccat cttgctgcgt
|
72121gttttggtga ctgtagaaat aatataaata tttcaaaatg tggcgtcaac cctccaccct
|
72181tcctatgcct gccttctttt cctccatctt tatccaatac ttacatcttt agatacaaac
|
72241ctggtgaata tttactccca aaaactgtgc cataaaagca gaaaacatat ccactcacac
|
72301tgatgtctcc atcctgagat ggatatattt ggtgagagtt gtaatttgcg gtttgccaaa
|
72361aggccacaac aatttgccag cagtgtgtgc accatgtcac cagctctggg gctagatggt
|
72421cacacggccc ccaaggaatg tcctttgtgc tccagcttta ggtgggcaac cctaggtctg
|
72481ccattaatgc ttcggaatag taagaaaaag accaagtaaa gcttaggaat gggtcggata
|
72541tgctggctca cgcctgtaat cccagcactt tgggaggcca aggcaggtgg atcatgaggt
|
72601caggagttca agaccagcct ggccaacatg gcaaaaacct catctctact aaaaatacaa
|
72661aaattagcca ggtgtggtgg cacacacctg taatcccagc tattcgggag gctgaggaag
|
72721gagaatcact tgaacctggg aggcagaggt tgcagtgagc caagattgtg ccactgcact
|
72781ccaggctggg caacaagagt aagactctgt ctcaagaaaa aaaaaaaaaa aaaaagctta
|
72841ggaatgttct cagtgttcat gacactgaga tgaatatctc attacgtgac acgtaatgag
|
72901atatttcagt tttccagtgt ttggtgatat gggtcagttc atgccctggt gtggcaactt
|
72961gtgattgcta ccaaatgagt ttgttgaagg agaaaatgtt aatttgagag caactatatc
|
73021aaccaggctc tgaacaaagt gatgtcactc cccttaatga attccagaca gcttggtgtg
|
73081ttagagctgg atgagttttg tctgtttaag ttgtcgggat attattatcg acataattag
|
73141gattcaacaa gccccttgtt ttgctttgcc cagccgtgcc ctctcaaccc tcttcactag
|
73201caccactgaa ctctgtctgc aaggggacca gcattttctt tgttcttcag acagaaagcc
|
73261gtatttaaga aaagggaaag catgagcctt ctgctttaga cctgaggatt tggaaggaat
|
73321caagagacca cagaRtcttg gggcagcaca gcctgaggat ggtggcacac gcaggggcgc
|
73381actccaaaag caggccggga agttggtgct gagagtcaga gacgtctgcc ctacatggga
|
73441tagagcatta ggaaaagagc aaaaaccaag gctgcccctt caatttgaca gtacaaccta
|
73501actcctggcc agttacctgg ctcagtgcat ccaaaagaaa aaaggaatta aaaggaagtt
|
73561gactgactga acatcagtct tggaaagcta gatttctgta aggtagtggt ttacctggga
|
73621acttgtcaaa aatgcaaatt cccagtcagg cacagtggct catgcctgta atcccagaat
|
73681tttgggaggc caaggcaggt ggatcacttg aggtcgggag ttcgagacca gcctggctaa
|
73741catagcaaaa ccccgcctct actaaaaata caaaaattag ctgggtgtgg tggtgcacac
|
73801ctgtaatccc agctactcag gaggctgagg caagagaatc acttgaaccc aggaggtgga
|
73861ggttgcagtg agccgagatc gcaccactgc actccagcct gggtgacaga acaagacccc
|
73921atctcaaaaa aaaaaaaaaa aaaagcaaat tccagggcct gaattgctga atcagaaact
|
73981ctgggggtgg gatccagtgg gtgggctgtg ctttaacaaa tgctccaggt gattctgatg
|
74041cagcctcaag cttgagaaac atggctttaa ttggtgtgac agtcatgtca ccYggaagtc
|
74101attcacttaa tctKcatcat agcctatgag atagatgcca ttaatgatct gatgttacat
|
74161agtgatccat gaggcatatg gaggctatgc agctcagcta aggtcacacg ttagtcagtg
|
74221gctcacttgg ctctgaaccc aagcaaccgc gcacctgagg ggaggtgagt cggagaggtg
|
74281gacacgcagg gcctcacagg ctagggcttc ccagattttg ctgtgcaaat catttgggga
|
74341tctcattaac aatcaggttg gaattcatag atccagggta cagcctgaga ttctacatgt
|
74401cttaaaagct cccctggtag ggtggccacg catccaggtt tgactgggac agagggttct
|
74461agggcgtggg gctttcagtg ctgtagctgg gcaaacctgg acaagctgtc accaagcccc
|
74521aggtgcttct gaccacactg tcagatgcaa aacacagacc cacaagatga ggagtttggg
|
74581ttgtattcaa aYgtgatgaa agtgttgaga gcatgagagt gacatcatct gctttatatt
|
74641ttacatatat atatattttc ttagaaacaa gatctctctc tgtctcccag actggagtgc
|
74701agtggcacaa tcatggctta ctgcaacctc aacctcctgg cttcaagcaa ccctcccacc
|
74761tcagcctccc gagtagctgg gattataggc atgcaccacc acacctggct aatttttgta
|
74821tttttagtag agatggggct tcaccatgtt gaccaggctg gactcgaact cctgagctca
|
74881agaaatctgc tcagctcagc ctcccaaact gctgggatta caggtatgag ccacagcctg
|
74941ctttagaggc tgggagacca atcaaaaaag ttttaacaac ccaggcagaa gccaggggtg
|
75001gccagaagat agagagaggg agaaaatgta gggtatattt tggaagactg aaggaaaacc
|
75061Ragaggcaag gatgaatcct aatatttcac ttcaggctca agcttttttt tttaaaagag
|
75121caagtttaga agaaaaaaaa aatgagagcc aggaaagaca gtgagacaca gaatgagaga
|
75181gaaagactca ggaaaattat tgaatagaat gatgtgtgat ttttttttct gtaggaaaaa
|
75241aactcattta ccaattaaag tatgacctag aatttgtaat gcaggggtgg ggtctctaaa
|
75301acatcccaaa cagcctaagt tagtaaagag ctttgaagag taaatgtgcc tactatggac
|
75361tgaagtgtgt ccctcatccc caaaattcat atgtcagagt cctaaccccc aaagggatgt
|
75421tatttggaaa agggtctttg gaaggcaatt aggttcagtg gggtcatgag ggtggggtcc
|
75481tcgtaatgaa attagtgccc ttattagaca ccaaagagct tgtttctctc tctccacccg
|
75541tacacaccaa agaaaggcca tgtgaggaca caatgagaaa gcagctatct gcaatccaag
|
75601gagagagccc tcaccacact ctgaccctac cagaaccttg atcttggact tccagtctcc
|
75661agaattgtga gaaataaatt ccKgttgttt aagccaccca gtcgatggaa ttttgttaag
|
75721acagtgccta ttaacatgtt catctctttt gaaaagccac aatgcagcat gatgcattag
|
75781acaactggtc ttgaggcaaa agttaaggga catcggtagg accatgacaa agatccaagc
|
75841cttgggacta gggcccRtca ctcagggttc caaagtcctg acataactga atggtatcca
|
75901actcaagccc attcacatct cagcttccca ccttgctgtc tgttactcaa cctctctgag
|
75961cctcagtttc cttgtctgta aaatgagaat aataacatgt ccctaatgga cttatgatca
|
76021taacatgagg tgatgtgtgt aaaatgcctg acacttacta gttgttccgt catctctttc
|
76081cctctttcct cttctacgtg caagataatt ttatttctaa caaggcagga aaaatcaaag
|
76141acctaaataa gtaaactctc ccaataagtg gtacatgact catgaattca cattcatcct
|
76201ccctgaccat ggatacatga cttggtcttt gtgtgccttg ctgtcctctg ggggatacag
|
76261cacctgcctt gcagggttat tgtgaggaat gaatgagata catgtggcat gcttagcacc
|
76321atgtctgaca cacttaagga atgcaagcaa gtaccattgc cactgttgct gtttggtatg
|
76381tgggtctttt caatcctgca catttctagg taattaggcc caaaatgcga gagaaataaa
|
76441agagattcag agacagScaa gagacacgtg gagccccaat cctagggcaa tggcttggca
|
76501aataaaaggg tgccacactt gtctagattg ccctccacag ctttctctgg ctgggtttta
|
76561tgactctgtc ttatttccac aattgcacca gaagttctcc cagggctgag accacgttat
|
76621ccctttctgg aggcccagtt acacttctcc caacaactgg gtgcatgtac agtaagtgct
|
76681taataaatat tcataatgag cctgttcaga aggatctgtg tcccatatct aagatttagc
|
76741caaggatatg ccagggccag gtcaggctct gatagttact gctgatgcca atgacacccc
|
76801acaggcagtt agcttcacag tggtggcaaa gtcccatcac atgggctcag atggaaccat
|
76861gattcagatg agtcatctgt ggtcacagac atgcctgtgg gcccaaatgg gacagagatg
|
76921ggacattagt gctcacaggc atggtgccaa acattcacat tatctcattt aagactcaca
|
76981gcaatcccat gaagtcagga ggattattac ccccgtttta tagatgaggc aactaagaag
|
77041cagaagtgta ggtaagtggc ccacatttgt accactggaa gatggcagat tgccagggtc
|
77101accattcaca ccctggactg accaactccW cagccattcc ctcagccaca gggtcaagga
|
77161tgtagatgac ctttgaggcc agaaaatgag ccccaagtat cccctgcaag gaccagagca
|
77221actctatgga ttctttgcta tataatctga aaactgtcta gttaaataat aatttctcta
|
77281aagaacacct gttactagtt tccaaattta ctctttgaga aggaagaagc agcccaattt
|
77341cccagaaaga gctctgtatc taaactttcc tctgtctccc ctaataacaa aggctggatt
|
77401tctggtgtca agtttaggta cgcagttggc tgtgtaggct ttatggcttt tcagtcacct
|
77461ttcagagtaa tctaaaattt ctaagcttgt ttcaaaggta attttcactc tatctcttaa
|
77521agcttttggc cgccctcaag ccatatgtta gaggacaaga gatgtcagaa gactaacatc
|
77581tgttagatct ttcccaacag tgtggcaatg acatcatatg cttcttttag ataatttgca
|
77641cattatcaga ctaattttca gattatctaa tcagcagaca ttacccttaa tcaacttggt
|
77701tctccccttt cagctctgca gagtacaaca tgccctccaa aggcgtgcta gagctggggc
|
77761tcttttttct ctcaacagag gtgaaaagcc taactttgca ccaggcatac cacccttgca
|
77821caaaaggctg agacctccag gaacctagaa gaacccatct tcaattccac agacttgaaa
|
77881aatcagctgg aaatacattt tatagactca tattttttta aatttccctc ttaggagctc
|
77941tgagtaYgct atagagagta tgttatattt acttatgcta ttaaataaaa gagatacaac
|
78001atataacaat aagactccaa acagatgttt tttaagttat ttgtttttgc cttctagtaa
|
78061ttgctactct ggcttcccac tgtctatagg aataaagact acacagaggg gcatagaaga
|
78121cgcttcccac tgtggcccct gattacattt ccatctttcc tctgcatccc ctaaatccaa
|
78181cattactatc agacccaaag acttccaatt gtctgaatgt gccatgctat ctcatacctg
|
78241cctgccttca tgtacagttc cctctacctg ggaagccctc tccctcctaa gaaattcctt
|
78301ctcattctcc aatggctaac ttgaatgtca cctcttcRgt gaagcctttg caaaccccct
|
78361aatgcagtag tcctaaagct tgagtatgca ccagaatgcc ctggagagct ttgtaagacc
|
78421cagactgctg gcccccatcc ttggagtctc tgtttcagga catccagtag aacctgagaa
|
78481tctacatttt caacaaggtc ccaagggatg ctaatgccac acttggaata ccactgccct
|
78541aaggcataga aagtaccctg tgcccttgag tcctgaactc cctcacggtt ctgtacacac
|
78601cccattgcac actcccactc aagactgtga gctcaaagac agggctgagt cctatttatg
|
78661cctgtcctcc ctagtcccag catatagaca atattcaata catggttatt acatggatgg
|
78721gtggatggat agatggacag atgagatgga tgatggatgg atggatggat ggatggatgg
|
78781atggatggat gggtgggtgg gtgggtgtgt gggtggatgg atggatggat ggatgggatg
|
78841gatggatggg tggatgggtg ggtggatgag tgggtgggtg ggtgggtgga tggatgggtg
|
78901ggtgggtggg tgggtgggtg ggtggatgga tcgatgacgt atacacggat ggatggatgc
|
78961atggatggat iagactgaat ttatttacac agcttttcat ccaggcccag gacttcataa
|
79021atgtctatcc tcactctaaa aattacctca aaaacatcat ctataatcaa ttcccactgt
|
79081gcagagaagg taaaaagaag ttcaaagagt ttaacatcac aagcctatgt taagggggtt
|
79141ttgaattcta gtccagagct ctttctgcta ctctacccca ctggggctcc ctaccaaggc
|
79201tgcatttaag tagtcacaat ggtatgcttc tgagtgtatc tttcagagtc ctatcctccc
|
79261cagctgccct cccttcattc atgtatgtgt acatctatgt gtaggtgtat gtgtgtgtac
|
79321atatgcatgt gcacacacac agtcatttat ttcatttgca aaaagtaggt gaaggtggta
|
79381aaagaaatgg aggccgaaga ggcacccagc ctcatgcagg gagagggtgg gatgcagccc
|
79441acatgcagag gaccccatca gaaaagcact atttcccaga ggggagtgtt tgagctccaa
|
79501gcatccctgg cttcctgtag ttgaggcaga gaggcaaggg cacacaggaa aggggacaaa
|
79561cgtacaggaa acacaagaaa tgtatactca ggagaaaatg agagactgag ggagaaacaa
|
79621aggcgYgaga gcatcagctt gggggccagg cgatcaggag tggcagtgga ttgctgagct
|
79681tgcagcacag ggcagcatgg gcgggggcgg ggaaggtcag cgccggctcc agcagtccac
|
79741tctgcccttt cagcagcagc accaggcgcg ggatgagcca tgggctctgc tgaagacaaa
|
79801gctggggggc gatagagcaa gcgacagcag gaggaccaaa gtcaaaaggt cgctactgct
|
79861gcaggtggtg caaacccagc tgcccttggc cctgcaaacc ctgtgtctgt aaggctgttt
|
79921ttccattagg cctccgctca catgcagctt gggtcaccct gcagctctgc taaaggggga
|
79981aaaagtcagc atttccactt cactggtgtc cagaccttct cctgggggag ccgcagatta
|
80041gcctcttgga ttaagctctc ctacctgccc ctcccctcca aaagcctcac caagggagga
|
80101tcacgaagct gagaccttag gatgctgccg agctgtcact tccaattcag cacacagccc
|
80161cagtagcatt taggggcagg atggatggga gccaccccct atccccaaac agtgggagca
|
80221gctaatgact aggtattaat gatgctggca attagtgctc acaagaaaat agtcgggggg
|
80281ctgctcacca ggggaatgtg ggagggagca gagcacacat tcggggcggc gagcaagtca
|
80341gcggcgtgtg tggtgcagag aacctgggac gaccagctgc ctcatgggtt tgtccagaga
|
80401aattgggggt gggggaaagg atgttttctg caggcactaa aagcctttct gctgtaccct
|
80461ccccactagc aaaactgggt taatcacaga gttttcRagg agggcactgt gagatgtcac
|
80521taaaaaggtg tttgtgagga ttctggaacc ttcttcgtgt ggggaggccc cggatccRcc
|
80581tgggaatacc tattattttc taggaggttt taaacccttg gccaggcaaa tgatcctttt
|
80641tgaagagccc actttctcat cagcagggtg agaaagagaa aaaggggagg gggagttgga
|
80701gtgtgtgcca ctcactgaca agcccacaga ggtgagaaca agccacccat gaaatttcgt
|
80761aggcagacgt ctccacatct ccacgtaggg cgaggggaga caggcacagc ttctttccca
|
80821agcaaggctg tgtggcctca aggggagaac actagaaggc caaacacacc cgcccacgag
|
80881ggctcgtgag aagatccaca cccgagtgct tgtctcagaa gtcaaccaac cctgagggga
|
80941ccacagggat cactggggag actgcctcct tctacttcgg gtctgcagca cacctccccg
|
81001tgcagccaca aacaccaagc acatggacgg acacatatgc acatgtgcac acacgcatgc
|
81061acacatatac aaaaacacac acacacgcag gtacacacac aatacacatg cacacaaaca
|
81121agcacacaca tgcacaaaca acacgcacac acatgcacgc acacacacaa Mgtacataca
|
81181caacacgtat acacacgcac acacaacatg cacgcacaca cacacacata cacgcacaca
|
81241caSgcataga cacacacaca cccggctcat aatgaggcta caggagaacc aaggaaaatg
|
81301agacacagac agacaagaag Mattccaaac cccagggcat gaataaagga acaaaatggc
|
81361ctgacatttg agaagagata taaggagata agctagcaca ggggagtgag aaataaggtt
|
81421accaagctaa taaacacttt agagagcgcg acaatggcga agaaacactt ttcagggagc
|
81481aaccaaaatc aaaggagatt cttctcagcc tcctcatggt gggagacaac agctccgtgt
|
81541gacctcttgg tcacttagac cagggaaaag aggagagaaa gggaaatgca agtattggct
|
81601gcctcagtac aggtcagtat cttttccttt ttgaaagaca agggtgactg gaccaaggaa
|
81661agctcttccc agagagaaga cctcagtgtt ggagctcctc aggccctggc aaggagaggc
|
81721gggcaaggct cggggggcac ctcctgctct gctgttcagg ttctgtccag gtgacaacag
|
81781caggtgagaa agcaagggtc tgtcgcacta aaggcttgca ccttggaagt gagcaaaaat
|
81841tcaagaaggt gctgaaggct gaattgcatc ccctccccac tcccaaattc ctatgttgaa
|
81901agcgtaaccc atggtacctc atactgtgac ttggtttgga agtagggtcc tcaaagaggc
|
81961atttaaagag gtaaagttaa aatgggcttg tcaggataga ccctaatatc caatctgaca
|
82021ggtgtcctta caagaagagg aaatgggctg ggcgtggtgg ctcacaccta taatcccagc
|
82081cctttgggaa gccaaggcag gcggatcacg aggtcaagag atcgagacca tcctggccaa
|
82141cgtggtgaaa ccctgtctct actaaaaata caaaaattag ctgggggtgg tgatgagtgc
|
82201ctatagtccc aactgcttgg gaggctgagg caggagaatc gcttgaacct ggaaggcaga
|
82261ggttgcagtg agccaagatc acgccactgt actccagcct ggcgacagag aaagactccg
|
82321tctcagaaaa aaaaaaaaga agaagaggaa atgtggacac aaaagcagat gccacagcac
|
82381gcatgcacag agggataact gtgcgagcgg acaggagaag gcagcatctg caagtcaagg
|
82441agaggaaacc aaccctgcca gcaccgtgac cttggacctc cagcctccag aactgtgaga
|
82501aaattaattt ctgtggttta agccacccca tctgtggggt tttcttatga gaaccctagc
|
82561aaacccataa agaaggcaat attacgaggg gaaagtgggg tggaggttaa gggagacccc
|
82621acactaatct gaaSaatggt cttggccaca ggtgtgttct ttatttcaaa tctttggtga
|
82681aagtggccag tggacatcag ttgactaagt cgttggctaa cacgcatcct ctaatcctag
|
82741agtctgaata ttttaaacgt ctgatccctt tcactgcatt gagttgttca ctttcagaac
|
82801acctaccacc aaatcttctg aacaaaatga aaaacacatg gcctgtccac gaatattctt
|
82861cactgagaga tctcagtgtg gcccacatct tcaagcaggc tctaaagatt ccattatccc
|
82921atttccatgt tgagatttct gcaggcccag agaccataag ggatgttcta gaggaaagtc
|
82981aaatggaaaa tgctaagccc ctttggattc cctaattcat aattggaagt tgaggtaaga
|
83041aagcagagaa acggaaacac aaaatcttca ggatcatttt gggtcttgag agcccaacat
|
83101cccaaacgac aaatccaccc agatcacatt tgccatttga atgctgaagc aaagaacatg
|
83161gggtctccag gcagcatttc taaggcagga gagccctgta ccaaaatgtg atcccctccc
|
83221ctctacaaca aaaccacagc aatagataag aatattctaa ggcacttcRt agccaagcag
|
83281gcatttcgaa tgtgtgtctg aactgacaca cctattacct atgcccaacc cagtctgagt
|
83341ggctggctct tcaggagtga gggaaaagag ttgtaggtct ggcatctgac agtggccagg
|
83401taaggacttt ctcttctgct taacactcac cttccttcct ctgggagcag agcagggtgt
|
83461gtgagcccag ccctgctatt gctaagccta gggttgggct gagctgcagg ggcNgctggc
|
83521tggctggctg aaagggccaa cacactacag cacattgaga ccactcaacg gttgctacca
|
83581gaagatgcca gcagtgagaa aaaggaacaa ggaacgctcc ccagcctgtc taacccactt
|
83641cttcactgcc ccaacctaac aagtaggcac tcacgcctgt ggttctcatt tctgtggttg
|
83701ggtggggacc gagtctcctg gtcttgagct tcatccccct cctcgctggc caggtgagtg
|
83761tgagcatagt ggtagctgag ccccggtcgg ttcttgtagc gcttgccaca gactagagag
|
83821gaaaagagga aaaaagggag agatacaaat attagcaacc tgtgcagcca ccgctatcat
|
83881tctcccagac agtgatccca tccatccacc ccagagccag gcttccctta aaactgtctc
|
83941ccatcccaac atccctttcc cccacccaac agaaccaaca cccttgtaac aactcaggtc
|
84001atggaaagaa aaactgtaaa agtaaaatat gaggttaaga gctgtgtgag cactccaccg
|
84061tttctagctg tgagacccag ggcaagtcac ttgacctctc tgtgcctcag tttcttccga
|
84121gataaaatgg gaacaataac agtacttacc tcacagggtc attgtgataa gtttatctct
|
84181atgcaaagta cttaaaacaa tatcaggcac tttgtgaggg taattgttat gacgttgaat
|
84241tcaaagggca ctgggaatct acccaatcca acatcccatg acacagatga ggcaagtgag
|
84301acccagcaac accaagtgac ttgcccagga gcacacaact agtgtggcag agccaccaga
|
84361acccatgtct cctgggttcc tgtgcactgt cccttccacc accccatggt tggcctctgc
|
84421aagaagtaga aaagttttat ctggataatc cttttgatgt ctcacccagc gattttgtgc
|
84481cagaaacaca tgctgcactt ctaccatgaa cgccatggag ttaaagcatc cttggtgagt
|
84541gtagtcacca agagcttgtg cccctgatgc cccagggcag ccaaatctgt aaaaggtgct
|
84601ctcacaagta ctacctctca aatggggcag tttgagccaa gggcagcgag caatcgaaat
|
84661gtgccttctt ggagccagga agaaagggca gcagttctgt tggttagatg ctcagttcct
|
84721gggaagcaga agtctggcta aatggctcaa ggtcacacta ccaccctcaa cctccccaca
|
84781tagggatcat tatctcggcc cctaggggga cggcattgct ggtagcagaa acctcgagag
|
84841tcttcccagt gaaatgtcca tgccaacctt ctatgcttgt cccccagcct gggtccccat
|
84901cagagcaaac caacctgctc tctgctggag tgcctgaaag ttacaaattc taaaagactt
|
84961ctcccttgtg ctgacatgac cacgtcatac aaggaagcat aaatgcttca caaggtggga
|
85021agagcacaac tttagcatca ggcctgggtt caaatcccag ttccagctgc tgaggttcac
|
85081tggctgtgtg gtcctgagag tatacagaag tgctgtcatc cagtcatctt atccaatacc
|
85141cttattactt ctgatagagt ttctcttcct accagattct cttggggttt ttcagtagac
|
85201aaacattggc caaaataatg tcacctcttc ttccccatat ttacataaac tattttatct
|
85261tagcttagat catttgtaag aaccaccaaa acaatatctt caaatggcaa aagcaagcat
|
85321ttccaatgtt aatgaaggtg gatttagtgt ttcactgttt agaacgRtgt atctggctaa
|
85381tttttagtct ttaccaaatt taagtagttc ttcttattcc tgYtatagag ttttattata
|
85441ggagaatttt atcaactacc ctttcagcat ctactataat atgattctcc tttagttggt
|
85501tgataaggta aattacgttg atttcctaat atttcctatt attgaaccat tcttgcattc
|
85561ctagaatgca ctccatttgg tcagagtata ttatttattt gatatactgc tgcattctgc
|
85621tttctaatac tgcatcttga atctgtacta agacttgagc tcaatctata atttttggac
|
85681tatcttttat taggtttcaa ttttatggtg atgttgattt ctaaaaatta actgaagagt
|
85741tttgctgcat gaaattggac aagctgcagc tctgtgcctt ttcttttatc tgaaaatgag
|
85801gataacagta cttatcttgc aggatgggta aaggtattat aaatagcatt tgcaagcagc
|
85861tctctcaata cccagcacat aatagatgtt caataaatgg taaatgaggg gcaagggctg
|
85921tcagcatttt ttgctgcatc ttaggtactg gatcttcctg aaaagaggga ctttgaccct
|
85981tgcctcatat tataaaatct ggcaaYtggt tggacttctt tgttaaggta agatgagagt
|
86041ctgaaattca agttggtgac ccagtgacta taaattcaag gcccaatgtt tagctcccac
|
86101ttataagtag aacatatggt atttgatttt ctgtttctgc attaattcac ttaggataat
|
86161ggcctccagc tgcatccatg ttgcaaagga catgattttg ttctttttat ggctgtgtaa
|
86221tattccacgg aatatcctga acactgggta cacacagacg taaagatgga aacaacagat
|
86281gctggggact ccaaaagggg gaagggaagg aagagggcaa ggcttgaaaa cctacctatt
|
86341gggtactatg ttcactaatt ggatgatggg tttaatagaa gcccaaacct tagcattatg
|
86401taatatatgc atgtaacaaa cctgaatcta aaaaaataaa aaattaaaat aaataggcct
|
86461atcattggct acttacattc atatattctc tcttcctctc tctcataaat attgKaaaaa
|
86521aaataaaatt aaaataaaat aaaatagtgc tatgcatctt aattccatgt gactcaggaa
|
86581gctggaccca aagaggcccc tgaggtgcac tctggatctg cttgtggctt tttctattta
|
86641gctttttaga taatctgaag ttaatacaca gcaaattatg gggtcattgc atataaatcc
|
86701atttagttgc caggcatact gttagtaagg aataaatgct tattaaaagt aatgataatg
|
86761atatcagtat ttacacaaag aggcctcagc cacctctgca gatccccagt ataaactcac
|
86821agcatttcac ttgtgccatt ttgttatgtc aatcatcact gttgcttaat cacacaattt
|
86881caggatctta atggtcattt tgtctatcta gagaagtgtt ttattcccaa taactStaga
|
86941aggctgttct ggacaactcc attgataggg aactcactac cagtcaaagc aggcatttct
|
87001cctttagact ccttgaatta tggctatgtc tgcactatgt ctcttaagga cagtttcata
|
87061tcaatttcat cttgatatca acaactccac cttatatgtt gacatataca tactacgcct
|
87121tcaaaacata tttgttgagt ggctcatgaa tgaatacaga accattttgt gggaaggcca
|
87181ggagatgggc gaagaggcaa RttgYagaat ctaatccttc tacccacatt aagctcagac
|
87241taattgttct taaaagtcta caaaaccaaa cctaagcaaa aagctccctc tatctccttc
|
87301cccaacatgg tagaaagtaa taatgtttag agcaaatcct tttgctagaa cagagattct
|
87361caaacagtgg tccccagacc agcaccatcc acatctcctg gcaacctgtt agagatgcaa
|
87421actcttgggc tccaccccag actgactgaa tcagaaactc tgggggtggg gcccagtgat
|
87481ctagattttt aaaagccctc taggtgattc tgatgcacac taaagtttga gaaccactgg
|
87541gctagaaggc tggatctatt taggcttggc tccaccaacc ctatgtccac atgcccttct
|
87601tgatggatgg ccgtagcagg caggggcagg ataggcagcc ttgagacctt tgttcagtta
|
87661ttagcagtta ttagcagaat caggaccaga caatacatgg aggtcccaga agccagactt
|
87721cttcatgaag agccctctgg atggagctcc atttttaacc gggtatttgt accatgtcat
|
87781tcttctatca ccaggtcttc aattcaagaa atatttatta gacacctaat atgtgcccca
|
87841ccctgtgcca caagaaggac aaaaatgaac aagccccaga cccctccatg gaggaggtcg
|
87901cagtctagca gagatctgca tgtaaacaag ccagggggag gtgggttgga tacagggtga
|
87961gaccgtgcca ggcaaagagg gacatcaaag aggggacagg aaactggctt gagtgagtag
|
88021ggtagggctt cccagagaag gagcccctga catgagcagg acttcagcag gcaaaggggg
|
88081ctcaaagcac atgcagttat cacctctgca aactgcgaga agtctaacaa agttgaagag
|
88141gtggagcggt gggggtggat gtgaggaaga ctaacaggag aggaagctga gcaaggcttt
|
88201atcctgacaa tggggcagcc aggagaggat tctatcctga ggaccaagtt aagcagactg
|
88261acatgttaga aatactgctt aagattgtag ggcagaatat ggatttgaag gtRgcgaggg
|
88321gctatttcaa ttgtttacct gtgcaacaat gaggacttgt gcatggagag gaaaaatggg
|
88381gtgggagagg ggttaatgag agaacttggt ggaaaaggga gtgagtaaga aagcaaggag
|
88441gaacccagaa agactaacat ggccttcctg gccaggcctg acccagcccc acccacctct
|
88501ccagcctctt ctgacaccac gttctgcctc cacacagccc ttctgctcgc tggccttttc
|
88561gtttattata gatttctctt cccaccacag agtcttcaca caagctcttt cctctgccta
|
88621gaatgtcccc atccccaatt tgcctgatta aggtctaatc atccctctga tctcagttca
|
88681aatgtcctcc cccagggaag tctttcaaat caaaattaca accttagttt tttgccttcc
|
88741taggactaat cacgtgtcaa tacagacagt ccgcaattta caatgctttg acttttgatt
|
88801tttcagcttt acaatggtgt gaaagcaata cacattcgat agaaaccata cttcaaggac
|
88861ctatacagct gttctgtttt tcagttcagt attcaataaa ttacatgaga tattcaatgc
|
88921tttattctaa aataggcttt gtgttagatg atgttgccca actgtaggct aatgtatatt
|
88981ttcaaagtag gctagggctg ggcatggtgg cttacacctc taataccagc actttgaggg
|
89041gccaaggtgg gaggatccct tgtgcccagg agttgaagac cagcctaggc aacatggtct
|
89101ctacaaaaaa tacaaaaatt acaaaaaata caaaaattag ccacgtgtgg tggtgcgcac
|
89161ctatagtccc agctactcag gaggctgtgg tgggaagatc acttgagccc aggaagcaga
|
89221ggttgtagtt agctgagatc acaccacggc actctagcct gggtgacaga gcaagaaaaa
|
89281acataaaata aaaaagtagg ctaggctaca ctatggttta gtaggtttgg taggttaggt
|
89341gtaagacatg cattttcgac ttaggatatt ttcaacttat gatgggtttg ccaggacata
|
89401gcactaccat aagtggatga gcatctgtat gcatctctcc cactggcagc aagcatggca
|
89461ggtcctgtgt atccgcNgtg ctgtgtcccg atgaccagca cagggcctca cttgtggcag
|
89521gtgctcaatg tcagctacgg aaagcaaaga gatgcacatg tttctgacgt gggcaactgg
|
89581gtagaaggat gaaggaggaa aaccagattt aaagaaggaa gaaaatgagt tgagttcacc
|
89641taaagcttgg gaaagagacg tagattttgg agctggcagg gtggcaatgg atgttataag
|
89701tatggggaaa agtgtcagga agagactgtg gagagagaaa agaggtgcct acacaggata
|
89761gaactcagaa aacaccagga tcttaagaaa ctggtggaaa aagagaaact gattttttaa
|
89821aaatttgttt agaaagggtt gagtgtggtg gctcatgctt ataatcccag cactttggga
|
89881ggctgaggca ggaggatcac ttgaggccag aagttcaaca cccatctggg caacatagca
|
89941aggccccatc tctgcaaaag acaattcaag attagccagg tgtagtggca tgctcctgta
|
90001gtcccagcta cttaagaggc tgaggtggga ggatcacttg agcccaggag gtcgagggtg
|
90061cagtgagcca tgattgtgcc actgcactcc agcctgggtg acagagattc tgtctcaaaa
|
90121aaaaaaaaaa aaaaaaaaat tagtaattgt taagaaaaac tcacacagga gtgagcaaca
|
90181taagccaaag gaacagggtt tcaagacgac agtaacaatg acaccaccag tcacaggtcc
|
90241tgYcaacagc tattgagtgt ttaccacgga ccaggcccac tccaagtgct tcaagtaaat
|
90301tgactcacag caacctgcat ccccatttta aagaaagatg aggagattct gcaccgaggc
|
90361agagccacag taataaatta atcagatgcc tgagaagggt caagaaggtt ggagactaag
|
90421agaccactgg atttggaaat tgggaagttg ccttagcaag aagagaatcc acaaagtcga
|
90481ggagcacaac tgcagggtgc tccaagaaat gaggaagtgc tgatggggcc agctgtggga
|
90541ggaggaaaga gggaggttgg tgggtggagg ggagcttagg atcagggcag accagggtgg
|
90601agcctgtgtt ttaccagcct attctgactc ccaagtctta gtccttggaa tgatttcatc
|
90661ataggggcaa gaggaagagt gaagacttcc aagagttatt ttggttggat tgcatcagga
|
90721tgaaactgct tcatYacaat ggaaagaaac gtcttgaaat cctgctttga ctggcttaga
|
90781aaagccagca ctgtttctcc ttctgtgttt aatcatgtct tcctgtcact gcaaacacca
|
90841tgggccagct tcgtgagcct gtgacctgtg cttccagaca gggtccgagt tcagaaaggc
|
90901cccacacttg gtttaatgcc ctgctgttgg catcttgaaa ttcttaatat ttattgaaca
|
90961agggcccccg cattttcatt ttgcagtgga ccctacaaat cacgtagcca gttctagaag
|
91021tctgttgggt tcagagtgga gatctgagac taagttactc caaatagctg acctgatagt
|
91081ctgagagctg ccaaggtgaa cccaggtccc aaccagtcct gagtcaggca taaaattccc
|
91141ttctgagata atcttgaaag tctggccaga gtgattagct gctcagtagt catcatctca
|
91201gtgccatcaa ccacccaggc ctggcttcta gatcggctct gccctcagag aggcagaatc
|
91261tgcagcaggt aagtgggcag gctggatctg aactgcctgg gttcaagtcc cagctctgct
|
91321gttgactctg tgatcttggg caagttacta atcctctctg tgcctcagca tcctctctgt
|
91381aaaacaaggt ggatcatgac agcacacctg ctccccgcgg tgagacccat atgagagaat
|
91441gtatttaaaa caaagcccag ctcatgggga gtcgtggctg ttctcagctg ctctcatcac
|
91501cactgctgtc aaagtggccc aacaaagaga ataaacccca aagtggggag ttatttctcc
|
91561tctgaagtct ggagtggaat agcaaggaaa agagggtggg aaaagaaaca ttttgaaaat
|
91621aaagtactgg aaccatctgc tctcctttta tcatgtcggc attctcactc tggaaatatc
|
91681tgtcgtgcgg aatcagcctg agccccagga gcgctgaagc agcagagagg gtcatgcccc
|
91741atcttcccac tccagtctcc ttccccgggg gcaagcgctt ttgcaccatg cacctctgaa
|
91801gccaccaccc ctgggaccag tcagccctgc ctgtgcacga cctaaggtcc ttcttttcac
|
91861cttggcaagc gtgcacctgg attttgtgtt cctggcatgg tgcacatgga gagcagtggc
|
91921tgtgacaata agggaggtcc agcttgcctt ctctttctcc ttccccctgg ggcggatcca
|
91981tctgtcaagS tgcagaagga gtgtttgccc acttcccaat ccagaactgg attctgcatg
|
92041caggacctcc tgtctggagt tatggatgcc ttcagtgccg ctccaaaata tttactgcac
|
92101gccccctgcc ctccttcaaa cctaccccac tcctagtctg ggcgggggtc ggggggagca
|
92161gggaggagga ggaatcaggg gcagcttgtg tgaacaaagc cgctgcagca gacagcagaa
|
92221tccttcctgc cggggagaag cggctgcctt ccccactgat aacttaatga ctctggcaca
|
92281ttttcatcag cccaacttgg agcacacagt gggaatctga gccagtggtt tccgagagac
|
92341tgaaagcagt gactgaaggc aattacagga tgagcatccc agagacaaag cctgggccct
|
92401gggagtcacc agccagtcac cagccacagc tcattcccgg ctctgccccg tggcactgac
|
92461atacaaccct gaggacaccg cttccttctc tctgcagctg gacttcctca tctgtcaccc
|
92521agaccccacc atgcctgtca tctgccgatg cctccaaggc atcacaccta ccatcaggca
|
92581gcacccattc ccatgcagaa tctcacagct caggaggcaa ggatccccat tccacagatg
|
92641aagaaactga gtctggggga gtttaagcaa ttctctggat ggcacagcca gagtttgagc
|
92701cctggtctgt ctgcccttga agcacgtgac tgaaaggtgc gctggtgagt ctctgcttgg
|
92761cactgcctcc ctccccaccc accccaacgg cctggggctg actggcgtgg cctgcttcac
|
92821ccatgctccc ttgctctcgg caagaaggag gcaccagcag gagaacggag ggtgggaaRR
|
92881aaaacacgtg gggacttggg ccctgccctg cctgggcact gtgctataca ggggctgtat
|
92941aggggcccac ctccaagact ccagtcctgc ctggctctgg gaaccccatg tctcccctgc
|
93001tccttggagc tggggatagg gagggcttcc cgctctccct gtcagcacct tcatcttgcc
|
93061cacaccttca taatcactct ggcatcaaat tcccttccat ccagcccttc tgagtggaat
|
93121cccacatcct gccggatacc atttggacac atattcacac cctaccagac cggctcgtag
|
93181aagtttgggg ccaccaacac ctcccaacga ccctccatct tctctctgca gaaccatctg
|
93241ggggatggag gcattcctac aaccaattcc cccgagcagg gagaagcccc aactgagaaa
|
93301agccctgtgt gactcccaga tacaaactca gatcgggata aagcccagga ggtacttcca
|
93361aaagccacct gctcagactg ggtacRcagg gtacagKtgt tcatcccaca gccacttcaa
|
93421ctggccaggc ttttctcaaa agccaacggt ggatccaacc cccaggtggg cttctcctcc
|
93481ctcccctgcc cttgaagttc gaggccagca gactcggtgg ccttctagag accgggggtc
|
93541tggctctggg tctgatacta acccgctatg cacccttgga caaattcata cctttctggg
|
93601tcttgatttt tcttatctgc agaatatggg ggttggatca gatgatctct aagtcctttg
|
93661cattctagca cttcacaacK ctctgtaggt cctgaagcta ttatctcctc aactgtgata
|
93721ggaaaatgat gaggctccca gaggctggct acatccacct ccccccaccc caccctgcac
|
93781gattggcagc tgccgtcccg tggcttcata ccttctttca ggccaccctt gatgcttatt
|
93841ttaagctgaa ttcctttgga tggagacaca ggggattggg ggtaggggtg gggtaaaaca
|
93901ccctgatttt tcacagccac atttcttggg gcctggtggt gacccaggat ctatcaaact
|
93961ccagtgaccc aaaagtcctg tgtcttcatc aagggagagt gtcctgctta ttttgggaat
|
94021ttactagatg tgaggaagaa cagagacaag caaccagact ctcgtttcaa aatattctat
|
94081cacctgattt ctggatcctc agcagggaaa tgcagaaacc ccccaaaacc aaagcactcc
|
94141atgtgttatg ggaatgtttc ctgccctgct gagaagccgg gtaacagaat gcaggtgaac
|
94201tcgggagtct gccttcttgg gtcagctgat ttgcaatgtg accttgggca agtgacttag
|
94261tctctctcag cctcggtttc ctcgtctgta aaacaagggc aataacagtt tgtagctcat
|
94321gggggaggtg tgagaactgc aggagttcat cttcttacaa tgctcagccc agtgcctggc
|
94381acacagcaca tgttcaacaa acatcagcta tttttgatca ttcatttaac ttgatcagac
|
94441aactccctta gatcctgcag cagctagggc acagaacaca actggggccc cagcttaggt
|
94501gttaaataag taccttttct tgattcagta taaagaaaat aaacatttat tgaaaatatc
|
94561tatgaaccaa gcagtgagct aattgttttt acacaatttc tcattgaacc ctcttggaaa
|
94621cccactaagg ttaatattat tgtcctcacc taacagacca gaaaacaaag gctcaaagtg
|
94681gttttgtgat ttgcctgagg tcatggctag gaagtgacct ggtaaagatt caaatcctag
|
94741ctttctgact ccggagccac cttcttccaa ctggcatccc tttcagggtg gtgtctttga
|
94801ttcctgattc tagtgagtcc tgcgttagca tgtccttaat gagcttaaat taagagtgaa
|
94861actgaattct cttttcaatt gtacaataaa aataatttaa ataataaatg tcattgtcaa
|
94921catttctggg gaaggtaaaa agagaaaggt caaaaatcag acctgattac cctaagctga
|
94981ggcagccccc aggcatctgg gaatcctgct agcatcctct ctctcaatat ctctgtacac
|
95041ctcccatgcc aggacatcag tgcggcctca aatgctgagc aggttttatt tgtgagttcc
|
95101aggctatcca gtgtgattcc ccaccccctg cctgaggtag gccttcttcc acctacaatg
|
95161tcagtgtaag ctcctcagtg ccttagagga aacaacaact gtccattagc atctgttaag
|
95221acgtttctgc ctggattcct gccatttcca ccaactcata tgtcagtttc atcacactcc
|
95281caaaattact tcccctttta ggatattcca gttaagctac cccttttgtc tcaatgaccc
|
95341aagtgcaaga tgtcaagagt catcactgcc acctccctct ctcctctcct gctctccaca
|
95401tcctgtccat catctgccgg gttctgtgaa tttctctttc attaagtctt cttcatctgc
|
95461cccgtctatt tcactgctgc tatcaccacc atccagattt catgtcttct cctagctgac
|
95521tagaaaaggc tcttctcggt catcaggctt caggctttcc tccctgaaca ccgaatccta
|
95581cagaYcaacc ttcctagaga tgtccctagg attgtcatga attaccacgg accatgcagg
|
95641ccaacctcta agccaggggt ccccaacccc ccgggctata gactgacacc tggactgcac
|
95701agcaggatgt gagtggcggg caggcaagag aaacttcatc tgtatttaca gctgctcctc
|
95761atcactcgca ttaccacctg agctccacct tctgtctgat cagattagat gtcacacKgg
|
95821attctaacag gagcacaaac cctactgcaa actgcacatg caagagatct aggttgcaca
|
95881ctccttatga gaatctaatg cctgatgatc tgtcactgtc tcccatcacc cccagatggg
|
95941accatctagt tgcaggaaaa caagctcagc tcagagctcc cactgactct acattatggt
|
96001gagctgaata attatttcat tatatattac aatgtaataa tcatagaaat aaagggcaca
|
96061ataagtgtaa tgtgctcaaa tcatcccaaa acctgccctc cgcccctggt ccgtggaaaa
|
96121attttcttcc atgagtccct ggtgccaaaa aacttgggta ctgtggctct aagcacctca
|
96181gcctgatgtt cccagcaacc ctSgtctaac tctgtgcccc caatctccct acccacatgc
|
96241tctgggttag tcgagctgag ccttcttctt ccctggtatg cacatcccac attcccttct
|
96301ccagacattc atcaacagtt tggaagcacc actgtgctgg ggctgggctg caagttgatt
|
96361ctggcctggg ccctgccctc agaaggctca cagtccagcc tgagggagca gagaaacaaa
|
96421ctgtcatcac acaatgtggg aggcagccta ccaggaggta ggcacaaggt accagcagct
|
96481tccagaaagg gacagtgata gtgtgtgtgg tgggggaggg aaggagaatg agagagagaa
|
96541aaaaaaagag agagagagag atgaatgact gggatcaaat cttggctcta gcatttattc
|
96601actatgtgac ctcaggaaag ttaattaacc cttcctctcc ccagtttcct tatctgtagg
|
96661atagagatga ccaaagcatc catttcatag cacttttgtg ggagttaaag agttaatata
|
96721gatgaagcca acagaatatt ccaggtctat aatataagtc aacaaacttc agcattatca
|
96781ttattacctc ttccccctac ccctgggcac acccatccac ccctgggggc caatatcaat
|
96841tccatccatg cgccctaagg gccttcttgg catcccgggg ctgcactctc tgacacagca
|
96901gcccctcttc Rtgtgaccac tccctgccct gttccttcag tgctcactgt cccctcaatt
|
96961aaataccgcc ccggcagtgt gctatctcct gcacaatatc agcctttctc cttccaagca
|
97021tattggagaa agagaaaata agaccaaggt gggggaaacc tttgtcaagc acatgccacg
|
97081tgcaaagctt tttacataca tcatcacagt cagctttccc actgtgcccc atccccacca
|
97141tacaccggag gacatggaga ctcctacagc aaaatgactt tctcgatgtc acagataaca
|
97201agcagcagaa ccactccaaa gtcagggcac atcctgcttc acccagctct ctgcaacctg
|
97261gcagacccat caggctcctt gctttcctat actccccacc atgactcaaa ataagagaga
|
97321tcaaaggcca tgcaccaggc cctgcagcct cacaactgta cttctaggaa acaataaagc
|
97381attatgcaaa ggtatagctg gaacagtgct tttttttttc ttttttcttt tattattatt
|
97441atactttaag ttttagggta catgtgtaca atgtgcaggt tagttacata tgtatacatg
|
97501tgccatgctg gtgtgctgca cccattaact cgtcatttag cattaggtat atctcctaaa
|
97561gctatcccta ccccctcccc caaccccaca acagtcccca gaatgtgatg ttccccttcc
|
97621tgtgtccatg tgttctcatt gttcaattcc cacctatgag tgagaatatg cggtgtttgg
|
97681ttttttgttc ttgcgatagt ttactgagaa tgatggtttc caatttcatc catgtcccta
|
97741caaaggacat gaactcatca ttttttatgg ctgcatagta ttccatggtg tacatgtgcc
|
97801acattttctt aatccagtct atcattgttg gacatttggg ttgattccaa gtctttgcta
|
97861ttgtgaatag tgccgcaata aacatacgtg tgcatgtgtc tttatagcag catgatttat
|
97921agtcctttgg gtatataccc agtaatggga tggctgggtc aaatggtatt tctagttcta
|
97981gatccctgag gaatcaccac actgacttcc acaRtggttg aactagttta caggggcagt
|
98041gcttttaata gtaaacagat attagactgt ctaaacatct aacagtagaa cattgagcaa
|
98101attacgagac atgtccataa gctgtggcac atctgcataa tggaacacta tatagcccta
|
98161aaaactatgt cataaaatct atttattgac acagaaagat gttcctgatg tatcactgag
|
98221tggggcagMg gggcKttaaa atggtacgta tcatttctta gtcgtcttct gtgtgcgtgt
|
98281gtgtgtgtgt gtgtgtatgt gtgtatagac agagacagaa ttaatcctag aatggaatac
|
98341agcaaaacaa atacagcaaa aaattatctc caaggagtga gattatgggt catttttgtt
|
98401ttttcctcta tttttttttt tttgagactg cgttttgctc tgtcatccag gctggagtgc
|
98461aatggcgcaa gctcagctca ctgcaacctc tgctttgcgt atctgtaatt cctgattatt
|
98521ctgcaatgaa caaatactat ttccatagaa aaagttattt taaaaaaata atgaaaagca
|
98581cctctacaat ggttaatatc taccctatta tgggtcatct acacagaaat aggaattgtc
|
98641atgaagtgtg catcaagaaa cagttagtgg agagcaaggt tgtgactgaa tagaaaataa
|
98701ctccagaggg tgtgggtcac agcccagaga aggcaggtgt aggttagaag gtcaaatgcc
|
98761aagatgcgag ccctggagga gaggaggcag agacaggagg gtctagggac agcaaagaga
|
98821aacttcaccc tctccccagc cctgcctctg gccagtcctg ccggaacacc tgcaacctgt
|
98881gtccatgaca caatggcatt taaatattta aacagaccca gctttgctgg aacggcgcac
|
98941tcagtctcca gggatcaatc ccatgccaca agccccgctc cacaaatcaa gtttctgggg
|
99001gcaccgagcc tttcctcccc tccccgatcc tacccccatc caaggacctg caagacaact
|
99061gagtgatgag cccagcttcc cttccgcgac aaaggcagtg agcctgaagg ccgcgttatt
|
99121ggcttttcca ctgcagcttg aagcgaaaag cacgtgagcc ttaaagaata tgYgccttaa
|
99181tgccctcaaa aaaatttttt tcttagcaaa actgcaagag tcatctaact ctccctgctg
|
99241cactcaggta ggggtaaaac cagggtagtt tgaaagaggt tgaggtcaag cagattttct
|
99301gggactgcct tgggctcaag cttttgtctg tccagtcagc agatccaccc atcccatcgc
|
99361acctcttggc ctgtggcaca gtttcccgtg gtattcccca atccactgct cccttcatgt
|
99421cctccagaca tcttgcctcc ctagtaaaga gcatcattgt taagctgctg cctgggaaga
|
99481aaggcgccac tgtgtgggga aggagtgctg atcagggcag tccggaggcc caaaggagga
|
99541gccatcccct cacggacaaa ggaggaaacc agtgccatag caactgaggt gtagaaccag
|
99601gactaaacgt ccagcctgct cctcccatca gcctgatacc cttctctctg aagtacacca
|
99661ctgccaagaa acaagagact ttagaacggg aagagaccct agaccctatt ctgatactac
|
99721ccccactggg tgtggcaaca cactccccga ctgggtttct agaagggagg caacagggtg
|
99781aagcggccac acagctgaag acgcacatct gtagggtgga ggtggtagag aacagagact
|
99841ttgctgagac agaggtggcc ttgagagggc ccgctcctgg tgtgtgacac ctgacgtgac
|
99901tcaggagtga gtcatgcttc taggagggct ttagccatgt ctatttgcct tttgtcacta
|
99961atctagccta atgccgtagt tggggggcag tgattttaat agatttaaat ttaaaagact
|
100021ggaaatcata taattccttc catcctactt caattgtaac tactacctga ctccagcctg
|
100081cccgcctgat gcctagaaat tgcccatcga cagcggccag ggcttcacct cataagtaag
|
100141ttgtgcgttc tcattaatta actttgaaaa tgctttttcc gcagccttca agagaatgaa
|
100201actccagggt aggagagcat atgtaagggg cagttagtat ggaagatgtc ctagggtatg
|
100261gcggttctag agttgaggac gctgggatca tatcccactg ttcgcatcct agatcccagc
|
100321tgtgtgacca tggacaaggc cctacacctc tctgagcctc agtttcttca cggtaaagtg
|
100381aggtcaactg tccctgcctc tccaggttgg tgtgggggtt tacagaaata atccatgtga
|
100441aacacttagc ctagcgctct acacacccta agcacctact cacaggaatt aagaccatga
|
100501ttcaRaaaac acttcgagga aaaaagaaaa cttcctacac tgcttccctt gtgtctagca
|
100561aaagggcata tgcctgcttt gctcctccct gcatggctaa tgcttagaga caaaatgttc
|
100621tccctgaata tcacaacgtc atcaccaact tctttgctat gatgtttctt gaacaaagaa
|
100681aatggaaaag tgggtctctc atcaggagtc tgctccaatg acgctaacag aaaaattcgg
|
100741gcttgggagc aattaggaag agaagaggca aactcttgaa atgactttta aaactttcta
|
100801gcagcccaaa cccaaggatt ccttccacct gcctgtcccc agttatcatc ctgcctacaa
|
100861aatggggcta aggatactgc taggatttaa agcgattaag tgaattaaaa atcaagcgct
|
100921ggatagctga gttgtatatc aatgtgaaat aaatggaaag aatagattct aaggagacca
|
100981actaaaacac tgatgcaagc cagtggcaac ctgcctggag aattcctgga gactccagaa
|
101041tgtccagatg caaaaagcag aaaataataa gagctgagca gtcaggagcc agaagccttc
|
101101atgtttaaat gaagtagact tgtcactgtc aaaagccagt atacacaaga atcccctgaa
|
101161gagcgctcag aaaatgcagg ccccttggcc ttccctccag tgattctgat accggaggtc
|
101221tgatgtggag cccaggagtc tgaattctaa gaagcgtcta ggcattgctg tgcagctggt
|
101281ccgggcctac actttcacaa acaccaacag acttttccac aatgtcctat tcagttgctt
|
101341tttttgtgca taagaaacac ttttccttaa gcaagagatt aaaagggaag aaacagaact
|
101401ttaaccctta agcttggtaa actttcaagg taattaaaag agactggtta cttgctggaa
|
101461aacaaagtat tcatacatcc atacaccatg gattgggtaa aacataaatc atgttcaggt
|
101521gatttaacat ttctctgaga cggaagaaat tcaatgactg agtaaaaggc atcaagcaaa
|
101581ctctctatca cctgcagtta gcagctacaa taRtattcaa gccacccatt ttgcaaagga
|
101641agcttggagc aagaacacaY aggaccacta tattcaggaa Kgcattccag gaagggttaa
|
101701ataaatcaca tcagaatata gcttattacc actacacata aacccagaaa ggggttgggg
|
101761tccaaggtga tctaatattt tcataaataa cttgaaagat ggagtgggaa ttatgcaaat
|
101821cacaccatag atgatacaaa aatggcaggg acggcaaatc tgtggagaat gaaatttaac
|
101881tactgggcaa tgtctttaaa tttgccttta ttgaatcttg tatattgaag tcacatatta
|
101941ttggatctgt ttattgagac tcaatgggac caaatgcaga ctgatttatg gaagaaggaa
|
102001taatcaaacg cataagtaga aaagagcatg cacctggaga ggcatcgaca ccgaggctgg
|
102061gacaggctcc gactagtaag ctgttgagag ggtggacagg gcataagtaa ggagatatgt
|
102121ccgctgctct ttgagccaca tggacttgat gctacttctt aggaRtgcca tgcttaagtg
|
102181tagacctgga agggaattcc aagcagggtg ccatagagac tatggggtgg ggccctaagt
|
102241caaccaagaa tatatgggat gttcagaagg tctcccagac ggacaaagcc ctaatgtgcc
|
102301tattcgtagg ggaaagatgc gcaaacgaca aggggacctg taggagagaa aatcttcagc
|
102361tcctattaag gaaaaacact cattcgaagc acagctggca tcatggaaga aagggcagct
|
102421tatggtaaca ccatccctag ggacgctcga ggaggtggcc agacacctct ctacttagga
|
102481tgcattagag attattaaaa gcactccttg cccagtttgg gggtggtggg ggtgggcctt
|
102541gtgacctctc caaaggtcat ttctatccca aaggatcaca tgtctgaagg gcaccagata
|
102601aaaataaagt ctattaatca ccgagctgcc acacaatttc caaagagagc cagaacagag
|
102661aagggcaatc gacggtggcc cctgctccac cgagagaggg agaggaggca gcacgcatgc
|
102721ggacagagcc aagaaagcag ccgctgagac ttccagaaag cctgccgtca ggcctcccag
|
102781gcactacagg gcacacagaa ggtgggagag agcctgcggg gagggcatcg agagaagcaa
|
102841acgtcactga gagtcccgaa acaaagccat ggggactcag gagacagtgt gtgatgcaag
|
102901cactttgcag aaagaggggt gcccagtaag agagggatgc ccacaaacag cacttcatgg
|
102961agatgatcca caaggaggca gaagtcagag gcaaaggtgg gaggagagga actgggaggg
|
103021gatgaagtca gagaaaaggg cacacaggtg tgtgtgtctg ggagtccatg ggattatgat
|
103081gggctgggaa tccaatgaaa gctgcagaga tagagcaaaa agggatccca cggtctatag
|
103141tagcagacaa ttacatacga agataaagca ttttaaaaga ggaacaaatg gctgggtgca
|
103201gtggctcaca cctgtaatcc cagcactttg ggaggctgag gcaggaggat cacttgaaac
|
103261caggagttca agaccagcct gggcaagacc ccatctctac agaaaatttt aaaaacttag
|
103321ccaagcatag tggcatgggc ctgtagtcct agctactgcg tatgctgagg caggaggatg
|
103381gcttgagtcc aggaggtcaa ggctgtagtg agctataatc ctatgattgc accactgtac
|
103441tccagcctgg gtgacaacgc aagagcgtct cttaaaaaat taaataaata aaaatgaata
|
103501aacgaagaat atagtagcaa tgccccagtt ccaaagcagt tgttggcatt cttgatagat
|
103561gtgctggtca agccaaacac agctagaaag cccaagacgg tctgagggcc cttcccagcc
|
103621catggcttac agccagtctc tcaagggtca gcatgctggg gcttctatgt atcagagtga
|
103681aactgaacgc catgtaggaa gcaagaccca ggccaaggca ggcacctcct ggtgctgcca
|
103741aaaggcatca gaccccatgc ccYgctcctt cctcatcctg gactagaact gctttggggt
|
103801ggagacgtta cctgcaggag tcatctcagg aatggcatct gcatggagta ttaagcagcc
|
103861aaatgggagt catggagttt gagttcttct agcaaaatgt tctccaacca gctgtcaccc
|
103921cattggacac agaacaactt tttgaaatca aaagaggcca gtgaaggggg agacaaaaga
|
103981caccaccccc agggtgctcc ctgggcccca cccctacccc gccttgccag ctctctccct
|
104041gccttcaggg agactgcaga ccctggcgag atgggtggga cacccagagg gagacccgtg
|
104101ccagggtcca gcctcgactg tttcactgcc atcctcgctg cagcctcttc cctcctatgg
|
104161cgaagctctg catcctcaga gaggagaaga cggcaagtga agatcattag gagtgtggtg
|
104221gtgagggctg ccctcccata gaatgagcaa atggtacccg gtacagtgag aagatgacta
|
104281gggcacaggt tttcaatctg cctcccagtg ctctgctgtc tggagctgac cacctccctc
|
104341atcaagctgc aggtttcccg aggtccaccc actgccctgg ctccctgcga ctcccctccc
|
104401gtgggctccc tagctctgtc tgcacgccct aaactcagga gccagccagg cagtcgcttg
|
104461tccaaaagat gtttctgaag caagcaagaa aggctggaga tagattgagg gccatttatt
|
104521aaagtaagtc atcgtcatag aaagattcat aacttgccct acctaggaca ggagaggaag
|
104581agggaaagga aattaaaggg aaacaaatga aaagccatgg cgagccaagt acctttgtcg
|
104641gagggttttg agttatgctt ttgtttgtaa ctctctgaaa tacagaaaga aatagaggat
|
104701gaatcttaaa ggagacagag cgcgtgagag agagagccgg aggagagcca cacaggaggc
|
104761atggcaggag gtgggggtgc agaactgagg gtgggggcca ccccagctgg cttcccctct
|
104821gcagaaaccc cctggggcag cagaggccca aggaagtggt gactgcggtg gaggcggcag
|
104881gcgagtaagc tggggtgcag acagaggaag aggagagcac acactgaggt tggcaggcgg
|
104941atggccaagg aagcacaggg aagaggggcc ctgggggcag gcgcacaggR aggaaggaag
|
105001gtgggaccgg cccatactta ctgtcacaga cgtaaggttt gtcgtggtct tcctgagagg
|
105061cggcgtcgtg cctcctcctg ccccctgcag agccgcgagc ctggggagac attggggtac
|
105121aggatgcttg ttaccatggt catcactaca gctccggagc atgcgctctg cgagctcctt
|
105181acaccgtctt catcccaact tttgtgccaa caccagtccc atcttacagg ggaggaaact
|
105241gaggcccaga gaggtcagga gacatgcccc caaatcactc agttgctcac ctgtatcacc
|
105301tcattaaatg ttcacaacKc caagaggtgg tttctactag ggtccccatt ttacaaacca
|
105361aaggactgaa gccatagaga ggttaagtag cttgcccaag gtcgttcggc tactcagggc
|
105421agctgtactg aaaagccctc ctctacMaaa ttcccacaca ctaccgtgcc Rctgaggccg
|
105481cttcctcctg ctccttagcc tcctagcttc actgRcacag ctgaggttga caaccccagg
|
105541cccctcagca gaccagctga tgcacgtatc aggagcaagg cctgacgggg gcaaggcWag
|
105601gcttctgtgt ccatccccgc agtgtcgcaa gagccagaca gtcctgacat ccaggcccag
|
105661tgcacgagtg tagMtacagg ggagctcccg ccaccagccc atgcttggcc tactcagtag
|
105721gggtgggctt tggctaaggc ctccctgtgt ggtctgcctt gggccttcag ccagtgacga
|
105781agaccttgac ccccatggtc tcctgggctg gacttctgat accaccaccc tgtgtgaatc
|
105841tcccagggtg gcggtggaat gagctctacc ttcaagaatc aaagagccca gtcagagagg
|
105901ttgctggcag ctctgcagcc ccagggcggt ggtgacaaga acacagcgag gtttattttt
|
105961aaacctttgt aagtcccaca ctggtcacgt gtatagcacc ctcgcctctc caggtcattc
|
106021tttggtaatg agtagcagtc aactcccaac caaggaaagg gcctgtcggg gtctttgggg
|
106081acagagagga aggggcagca ggtgaggaat aagacctggc agcagcctgg ggtgcagggg
|
106141aaatggggca gcccctgggg cctggcttgg aaaagtggcc atggggactt gatggtggaa
|
106201aggccttgga tactctcaca cacacactca cactctgtgc acacacacac tccatgtaca
|
106261cactcaccgg ggacttcaca gtggaaaggc ctgtacccta ggcctgcaac acacccactc
|
106321agaaaacaca cccacttccc aatcaacacc acctgccaag ctaccacctc tgccacctcc
|
106381tcagcttgtc tctctccaaa acaaattcca cttcctccct ccctcccacc aStctccctc
|
106441cccaccccac ccctgcagcg ctgacagcca gcagccctcc tcccctcgcc ctcattactc
|
106501agagttgacc ccaagaagga tctgtaggtg ctggcagtca ccccgggcac tgacaggcct
|
106561cctgcctgcc cgcactgccg agggtggtca ccctcagctg ccctccccct ccacacccct
|
106621ctgtgaagcc agggacagct tgacatgtag cctgcagccc tgtcacagcc gcctctgagc
|
106681aggtgaaagc aagtcaagca gaatgacgag gcaacagcag actggggaag gggctctggg
|
106741agactaaaaa tacctccatg gggaagggga ggagtcgagc agaactggat gtacgagggc
|
106801ttctggggga gctgccagca ggaaagggag ggtgctgtgg gagccaggtt ttcatctcct
|
106861acagcagggc tgaccagcag agtgactctg tgccacactc gctttgcctc agtttcctca
|
106921attgcaaaat ggggatcgtg tctatagggc acttcagggg acatgcaagg gactcttcct
|
106981gaggcagYag cactcttagg gtctcttaga agatctcagg tttggaaact cagaatccta
|
107041cttggccttc tcaaatgtca cctcctcaga gaagcYctcc ctgaccaact tacatccact
|
107101cacaccctct ccattgtttt ctttcccctc ccatttcatc atggcactga gcgctgtctg
|
107161gcattagatt atacctgtgt tggtttacaa gttgattttg tctcccctac atggagagac
|
107221aaacatggtg gagaccatgt ttattttggc ccccactagt ctcagaacct ggcacagggc
|
107281cagccacata agaagcactt aataaacatt cgccaaatgg atgaatcaat caggcaggca
|
107341gcgagtcagt catctctggt tcttctcctt cattctctgt atccaaatgt tattgcttct
|
107401tcctccaaag gccatctagg ctttgcattt cctttccatt gcacacccta atccaggagc
|
107461tcatcgactg acccctgagc tgttcaaaga acccactaag ggggatctac ctccacattg
|
107521cccccctagt ccaccctaac gggggatcta cctccacact gcccccctag tccatcccaa
|
107581gggactttca gaccattaga caaagggatg aaagacagga gcccatggtc ataggttcac
|
107641gcattcacac gttcattcat tcattgccat ctacaaccca cttacacagc cagtggcaac
|
107701ctagtgctga tcccctcggg ttcaccccat gattgtgctc tcctctgccc atgcacatct
|
107761gatccaggct ttgcccttgc taacctccac tcctccaaga atcttcctct tgccacacta
|
107821aggagtgaaa agagcatccg cttaaagtca gatagacaca ggttgaaaca ccagctatgt
|
107881gtcttgggca agttacttct ctaactttta gttttctcaa ctgtaaaatg agcacaccaa
|
107941cacctatata gcagagctgt tgagagagtt tgagctgaga gtgtgtgaaa Scacagggga
|
108001cagcactaag tccacaggaa gcactcaaca catcatttcc cccctccttg cctaggctga
|
108061tctctctcct ctgaactcct gttgcctttg gttagtgcac agtcaggtgc ctgctgtttc
|
108121taatggtatc atgggtatta gcatcttctt cccagtttga ttcgaaggtc cttgagggca
|
108181aaaatggcat tctatacttt attatgaccc cctaacactt Rgcacatagc gtgcaaagct
|
108241cttttgcata tagtaactca gttaattcct acaataaccc tatgagttag accaagcagt
|
108301gttatgattc ctagctggcc cttgatgaag caggttctca cctgtccaca gtcccagggc
|
108361cagcagaagg agcaggacct aggtctccag gctctgttat agaaagcttK gaaggtgacc
|
108421agccaaagga agccaatcct tcttccccaa gaactgccca ccctacttca ttcctctcta
|
108481ccagtattcc cacactgctg ggccatggca gccatgagtg taccacatgg ccctgtccca
|
108541ctggccacag ttgattggct ggctcgggag tagtcacctg attcaagctg ggccaatcag
|
108601atcctacctc caaggggttt ggaattagaa aacagtgacc ctagctagta taggccactt
|
108661gaactgaggg cccatacatt caggagcctt atggggccat gtacacatgg aagcaggaag
|
108721aatgaaggag ggagaagtag aggccagaaa ccacctgggt tNctgtttcc caatgctaag
|
108781tccctgccat gttcctgctc ttcctgtggt ttggatcttc aaaggttgct caaatttggg
|
108841gcagtggcct ggcagctttt caaatccttc ccatttttat tgaagctgaa agacccttga
|
108901ctaggacaga ctcggtccca agcWgagagc tagatcttct ataccagttg ttctcaaaca
|
108961gtgtggccca ggaatcctgg gggatccctg agtgtccttt cagggactct gcagtgtctg
|
109021aactattttc ataggagtcc taaaacgtga tctgccttgt tcactctcac gctctcacag
|
109081gcatccagtg gagtcttcca gaggcgacat gacacgtgac gatgctgtca ctgtgtgtgt
|
109141attctctagt ttaaaatttg ttttattttt cttgtaaatc ttttttactg ggctacctct
|
109201taaaccacaa taggttcaga gagacaacct ttttaatttc taaaatggca aatatcatta
|
109261gtggtatgaa tattactggt tataacctga ataacagcct ttgggggctc tcagtgtaag
|
109321gaattcctga gatcaaaaaa attgagaacc actgctctac acccttgcta tttttttNtt
|
109381ttttgagacg gagtcactct gtcatgcagg ctggagtgca gtggctcaat ctcggctcac
|
109441tRcaacctcc gcctccgcct cccgggttca agtgattctc cgcctcagcc ccctgagtag
|
109501ctgggattac aggtgcatgc cggcatgccc agctaatttt tcatattttt agtagagacg
|
109561gggtttcaca ctgttagcca ggatggtctc aatctcctga cctcgtgatc cacccgccYt
|
109621ggcctcccaa agtgctggga ttacaggtgt gagccaccgt gccaggcctt tttttttttt
|
109681ttttttgaga tggggtctca ctctgtcact agggctggag tgcagtagca caatcacagc
|
109741tcaatgaagc cttaaccact caggctccag tgatcctccc acctcagcct cccaagtagc
|
109801tgtaaccaga ggtgcacacY gctctgcctg gctaattttt tcagagatga gttctcacca
|
109861tgttgcccgc aggctggtct caaactcctg ggctcaaacc atcctcccac ctcggcttcc
|
109921caaagtgctg ggattacagt tgtgagccac cgcacccagc ctacaccctt gctatttaaa
|
109981gtgtggtcct gacaccagca gctccagcat cacttgggag cttattaaaa aggcaggagc
|
110041tcagccccca ccccatggac ttactgcatc agaatttgta ttttaacaaa atcctcaggt
|
110101gctccatatg cacataaagt ttgagaggca cctgaacacc acagtacata aataaatact
|
110161tcatgattga ttgataattg attaattggt aatactcaca tggatgactc acaagaatct
|
110221catgaatttt aaagagcttt gacttcttgg gctgaagtta ccaaagacac aattattaat
|
110281tgttgggctc ccctcaccac tcagagaata cccattatca aaattccaag agttattccc
|
110341tttgcttgcc ccctcctgat aatatctagg cagtatgaag cactcaaaac ttactgatga
|
110401agaaactgag gcccagggta cttatacaat ttgcccacca tcacagaggt tacataattc
|
110461atccaacgtg tagtaagtgg tagagctgga atttgaactt gcaaggtcta agttcaaata
|
110521aagcagagcY tattctgtaa tccctacctt agccctggcc tcctcagtga gcacacaaag
|
110581cacctggggg cttgtcaaag tgcagactct aattctcatt aatctagtgt ggagtctggg
|
110641cttctgcatt cctaatgagc tcccagatga tattaatgcc accatccaga gaccacacac
|
110701agaggtgtca agacitagac tgcctctagg ttctgacaag acaaatgggc atagttgttc
|
110761tccagtgcca gcagcagctg gaatatacca ctttaaatgg tgggcaatga gctgggtatg
|
110821gtggctcatg cctgtaatcc cagcactttg ggagacccgg acaagaggat cgcttgaggc
|
110881caggagttcc agatcagcct gagcaacaga gtgaggcccc catctctaaa acataataat
|
110941tataaaaaat aaagcWtggg caaaacagct gaactgaggc tgtgagtgca gcagcttcac
|
111001acaccccagc acaggaggct tgcccacagc cttctgggtc cttccatggc tccgtgcatg
|
111061ggtaacatgt ccacagtatc actgtacaac atggaaccat tcagctgctg cttggccagt
|
111121atctggtggg cccagagcca gtctaggctc catccagccc cctcactgtg ttcaggtgtc
|
111181tctcatctcc cctacagctg aaatacgact tttctttctc ttttccatca ttcaatcatt
|
111241cattcgacaa gctaatcatt ggctatatgc tgggccctgg gccaggcatg aactcagagg
|
111301agaaagcaca gacctgtgtt caaatcttag cctcttcctt actaggctga gtgaccttga
|
111361acaaattgct taacccccct gggagcaata gtaccagctt gtggaaatga aagaagttct
|
111421gaccaataga aatacaatgt gagccacact catcatttta aaatttccag cagcacattt
|
111481tttttaaaaa aatagatagg tgcaattaat tttaataata tattttattt aacaatatat
|
111541ccaaaatatg atagttttat aatttaatat aaaaattaag aatgagatgt tctgcattcc
|
111601tttttcatac taagtcttca aaatttcata tttattttat atttacagca catttccatt
|
111661aggactagac acattttgag gactcagtag ccacatgtgg ccagcagctg ccataatgca
|
111721cagtgcagaa atagagatag gagtctaaag cacctggcac aaaggcatca ctctctatgt
|
111781ggtagctctt gttatacaga gcccatcaca ttgcctggtt tacaggaagt acacagtaaa
|
111841tatacatggt tgcactgact gctgatgttt tcacagacac ccaattcata tccactgact
|
111901gcaagctcaa tcttctaaat gtaggttggg gagaggtgtg aagaggacca tttcccacac
|
111961ttgcRtcagt ttggttgggg tgagagaagg aaagSaagtg ggtctggaca tgcacagctc
|
112021tttgggagtt caccaaaggY ccaggaagtc caagctcRaa agtctccttt aataatggaa
|
112081ttcaattttc tttttaatac cctcccctcc gtgaatgggt ctaggccagt ttatcaatgg
|
112141ctgcaaaaat cattaagtaa aaacttgatg aggaactgta taagggagag atcaggctga
|
112201caacactcaa atctactgat caattaaaac accacccaaa gcagaactgg acagggtatg
|
112261cccctgatgt gatacgagaa gaacctatca ccacctagga aggattctta cctccccaca
|
112321agaaatgttt gtacacacat acacaaacac acacacacac aagcacacac cttgaatcta
|
112381agcaagtttc taatcaaact accagttttc aggaaacaca gaggatggag aaagacatta
|
112441aataccaccc tcccaccact tctagaatgt gagaagttcc acaagacaaa caacccaaat
|
112501tcttcaacaa attaatggca tggagaaaaa aaaatgtgtg tggtggggtg caatacagaa
|
112561gagaatacag aagaggtatg ctgtggaatc cSggagactt cagtttcaaa caaaccaact
|
112621ataaaatggc attttttgac aaaaggggaa atgataaggg actagatagt aggtattata
|
112681actattattt tattggatat gataatgata tctgttaaag acacacactg agatatgtgt
|
112741cagttaaatg ataagatgtc tagaacttgt tttcaaatac tccagaaaaa aaatcaaaca
|
112801aacacaaatc aacaaaaagt aggagaaaag aagagacgag dcaagatagc caaaatcttg
|
112861ctaagtgatg aggctggtcc cagctgtacc agaagtgcac catcagagag ctgcccgccc
|
112921agcccctgca caggctgcac agccccacat gcgacaggct ggagcatctc agctcagtgt
|
112981gtgccgcgct ggccgatgtg cagcggccgc ctgggaactt gcttctaata tagtataaag
|
113041cccYgcccca gagctcctaa agcagaattt ctgagtgggg tcctgggaat ctgcattcaa
|
113101taagctctct cagtgatcct aatgtctgct gaggcatgag aaccacaaga gtggagagcc
|
113161ctgccatggt tatcattggc agcaaaccca cagaatgcct gggactaagt gcttatccgt
|
113221gggaggggta agagtcccgc ctagagcctg aaggggtgag atYctcaagc ctgagagtcc
|
113281attttccagg tggacagcag Yagtttactt ctggaggtcc ctctccacct ggttattgtc
|
113341acatgccctt gcagacccca gacggccacc acagaaagcc ccttcgggcg tgaactctag
|
113401attcaacctg aatgcctgga agtgcctgac cagtctcttg tttttattcc ttccacctgg
|
113461gttttttccc ctctgccctt ccccaggctc tggctttttc cttgtcccat ccRaggaccc
|
113521ctgggatggt ctcaagcctc cagagctcat gccaaaccca ctgggagcca ccagctgcag
|
113581ccccctgcta ccccggcaaa cttctttttt tttttatagt catgattatg gtttatttNt
|
113641tttttttatt atactttaag ttttagggta catgtgcaca atgtacgggt tagttacata
|
113701tgcatacatg tgccatgttg gtgtgctgca cctattaact cgtaatttaa tattaggtat
|
113761atctcctaat gctatccctc cccccagccc ctatctcaca acaggcccca gtgtgtgatg
|
113821ttccccttcc tgtgaccatg taccccaaaa gcaggtaccc tgactctgtc attctggcac
|
113881agcaccaggg acaaggcagg aaatgtccag ccttctttag taaccaagca gtggtgacaa
|
113941caggcacatt ctccttatct tccaccctca ccctgatccc acccttcagc cctccccaga
|
114001cctcaccacc cactcagggt accccctctg cctcctctcc tccctcttgc cagctctgaa
|
114061ctcttccagg ctacgacctg ggatcagagc tSttctggag ttttctcctt tgagcgttct
|
114121ccatgtaaga ccatggccat gatttccatc tagctgcagt ggagatcaat cgttggccgg
|
114181gcaccccagc ctccctcatc tctttcctcg ctcatgtcat ccccaactta cccgtcctct
|
114241agtcctgttc tttcgcttgg gaatatcctc ttccaaatcc tcttcttcat tcccttcttc
|
114301tacattttca tcattttcca aaaccctctg aaatgaaaaa aaaaaataga aaaggtgaga
|
114361aacgaaatgc aaagggaaaa accatcagag agtaatttta agggtgttct gatttgttgt
|
114421tattttttaa cMaagtgaag acgctgcctt tgcttgggca gttgggccct ctgaaatgct
|
114481gtctggagtt tgaactcttg gcactaccga ggctctccta agcccttggg ccccttccag
|
114541acaagtcctc ccagaacact gacctttttc cattcttttt gcccaagaag agttttctaa
|
114601caagagacta tgctggtagg ggcccttttc tatgtggggc caWaatgttt acttttgtaa
|
114661atgtaatgtt tctttttgct cccaaagggc cacctcagaa atatgaaaat gtttctcctt
|
114721tccctgccat tctggaaccc tgccctgtct gatgaaagca agtaacttcc tgttcatctg
|
114781accagattta acacgaatgt gctgttcata ataagccact gctttttttt cttttttttt
|
114841tttttaagaa aaatagactt tcatttagta cccgacttgt catggagctt aaagataatg
|
114901aattttaaat tatctctctc cagcagcccg ccagtcacat tgcaacatag aatccaattt
|
114961ccattttgca ggtgaatacR ctgaggctga aaacagtttt gagtgctcca gatcatccag
|
115021tgaagccatg accaaagcaa ggtcaggttc atcggctcag ggttccccat tcatttctca
|
115081gcacagtggc tgagaattcc agatgtaatc tggcatactc tccatgtagg ggcctaagca
|
115141cgtcactccc tttagaggaa ggaaggaggt aggatgtgtt cctctgggct taagggaggg
|
115201ataaaagact gtagcagagg acccagcccc acaatgggag taggaaaaga gggaaggggc
|
115261atggagctca ctgggctcca tgtcaggggg cccagagggg tttttgtttg tNttNttttt
|
115321tttctgagac agggactcac tttattgccc aggctggagt gcagtggcac aatcacRgct
|
115381caatgcagcc tcaacctccc aggcctaagc gatcctccca cctcagcctg ccaagtagct
|
115441gggactgcag gcacatgcca ccatgcctgg ctaatttatt ttttgtagag atgggggtct
|
115501cactatgttg cccgggctga cctcgaacac ctggtctcaa gtgatcctcc caccccagcc
|
115561tcccaaagtg ctaggattac aggcatacca tgcagatgag ctaccacacc tggccacctg
|
115621ggggKttctt tatgggctca ctgtgtgatc tagggcaagt catcatctct tcatccttca
|
115681gtttccccaa ttatacaata ggaattcatt cattccatct acaaacattt atctagtgcY
|
115741gactacRtgg caggctccat gctaggcaag ctgcaaaatg gctacagtcc cagccccaaa
|
115801tggactttcc agtctaggaa agggagaaca gatttaaaca atgtgcatat gtcaccatat
|
115861aattacaact cttctcaaaa cagtggtagS caagttcaaa gtgctatgag agggtgttag
|
115921gagggagttt tccctaatcc aagggccagg ggaggcctac atgagaacat gagctgagaa
|
115981gttgagatgt ggaggatgag caaagactgg ccttgtgaat gaggacagag gggagggagg
|
116041gaaaaggttc taggcagagg aaacagcata agcaaactcc ctgaggcagg gagaggaaca
|
116101cggcttgtcc aaggagcaga aaggccagtg tgaccagtgc ttagtggctc aaggagagat
|
116161ggcataagat ggagctagta aggggaacaa gtaccatact acacagggta accccatctc
|
116221ctcttccttg tggtgatggg tcaaagatca caaatatgtt gagaaggctg agacagtggc
|
116281acacactgca ctgttgtctg ataaccatcg ctgtttaagc cgcctcctgg atgacacctc
|
116341tggcctgtcc tcaaagcagg aagcccgggg tgagccacca ggcagtgatc ttccaccact
|
116401gcccctggct agaatgttct gctctaaatc acagggatca ggacacttct agtcacccaa
|
116461tccatccaaa gaactcaaaa caggtctagt aaattcttct ttgccttttc tactaggttt
|
116521atttgggaat ccaccagctg acagcactta aagggtctct gagccagcct taaccatcta
|
116581acagagaaga agcattgtct gctggacatg acctctggcc cataactagg aaacgtcagc
|
116641ccccattcac agtataagtc tcttgagttc ctgacctgta ggtgggaaca ctagcaaaag
|
116701ccgactgaga cagtgacagg tcaaatgctc tgcagccttt ggggcaaaga catagtataa
|
116761atataaggtc tggttatgac tgttgttgct gttcgtagaa ccatcttgca aactttccag
|
116821gtcttgaagt cacttaatca tggtaagttc caagtgcctc gaatttaaag gtcatagcct
|
116881ctggcatctc agtacaactc cgactctcat ttttcattat aagggtattt attacccgca
|
116941atatggactc tgggttggaa ggtgaaagac tggtagaggc agctgagcta gtccccagag
|
117001tgtcacatgg cctccatatc tgggagtaaa ctgacttctc ttctccctga ggctccatcc
|
117061tccctctgcc catcagcttc cctgtgactc taaagcctct gtctatgccc tgggcctcag
|
117121atgtgatggc ggcagaccca gtgtgtctgc atttcctgcg atgcggccct gacaccagaa
|
117181gcctctcgac ataattcagg aggagccagg agtttctaac aaacaaagct tgtttcagac
|
117241ctcaggaagc ggagggggag tcctgcatca ggagtcgcYg acgggggtgg ggtgtccaac
|
117301tacaaagtca gctgaccccc cagtaacaga catgcattcc ttgtccaagg acattatctg
|
117361gaaaataaac acattttaaa ataacttttc tccctgttac tctaaacagt ctttatggtg
|
117421ataacagcgg tttgtggttg tgtttaaaaa aaaaaaatcc tttttaaaga ctacattatc
|
117481tctggcctgg aatactgcaa aaatctcctg atttccctcc tKccattgct ggccccacat
|
117541ccaatctcct ctccatgcag caggcaacag gatctttatg aaatacaaat tcacggccct
|
117601gatcaaaatc ttccaaatgg cttccttctt tatatcacat ggaaccaaaa gccacttccc
|
117661tgtcctgtgg gaactaggtg gtctggtctc ggcccacctg tcaaactcct gggctctttt
|
117721ttccctggca caatactccg gccacacagg tcttctgttc tctcaacaaa accagctctg
|
117781acctgtcttg gggccatcac acccactgct cctctgccca gaaagctctt ccccaggacc
|
117841atcactttcc tgactcttct catcccatag ggttgaggtt aaatccctca actcgaccag
|
117901atgcggtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcagg cggatcacga
|
117961ggttaggagt tcgagacgag cctggccaat gtggtgaaac cccgtttcta ctaaaaacac
|
118021aaaaaatagt tgggcgtggt ggtgggcacc tgtaatccca gctactcaga aggctgaggc
|
118081aggagaatcg tttgaacctg ggaggtggag gctgcagtca gctgagattg taccattgca
|
118141ctccagcctg ggtgacgagg cgagactcca tctcaaaaaa aaaaaaaaaa tccctcatct
|
118201tcctcaggaa ctctactctg atgctgaatc ttcatactgt ttgttctcat ggattttatc
|
118261ctaaaatgca cttattttat ttgtattcct tgtttcctgc ctgtgtgtca cattcgaata
|
118321tgagtagaga ggataggtat ctcttggtct ctgtgtccct agcacccagc acagtgcctg
|
118381cacagaggaa gccctcatga aactttggtc aaatgaatga atgaatgaaa aagcataatc
|
118441cattcgctac atgtgtattt taataatgca aagtcaataa aaacacgtaa actcatttga
|
118501cttatggtcc tggctttgtc ttctagcaca gtagacagca gacccatgcg ctgcactcag
|
118561cagaccttca gtttacatag gagatgatgg tgacatgatg acgacaatac agcaccagcc
|
118621cagtgctgca tgagaagaac tcaagcccac caccagcttt aaagggaaag ggacccacat
|
118681acccagagca tcaaggctct gggcagtggc tctgccccat Kcattgattc tgtcaaatta
|
118741catgaactaa gcaaaaaaat actctagcaa gtaacacaga gatgacagac cttgacttca
|
118801aaatctgaaa gtcacataca cacacacaag gaagaaagca gtaggtggct taaacaccaa
|
118861aggcaagaag agatccctct ggctggaggg gagatcaaga aaggcttgat ggggaaggtg
|
118921gcactggggt tgagtctaaa agatgagtga gatttgtaca catggagatg gaagaaaagg
|
118981catgccagat aaagggcaca gcgggaccaa tggcatggag ggaagaaggc tgaagaacag
|
119041agcggcgaaa ggagtagtgg aaaataagcc tgaaaactag gttaggaatg gagaggacac
|
119101gcccaggaag gtcacgctca tccttttcga tttatttagt gggaaacaac agttttttag
|
119161cagagttttg ctctagaaca aaaggacagc tagcaaagta ggacatgtca gagacgggaa
|
119221gaactgggga cagggcgatt cctggaatct gttccctcat gtgtccattc aacaaatatt
|
119281tatgttgcac ctggtaagca ccaagcactg tttgggtgct tatgagatat aagcaagcaa
|
119341aactggcaac ggatcctgcc ctcgaggagt ttacattcta ctggaagaaa acagacaata
|
119401aacaataaca taataagtaa gtaaattaga aagtacatta gatgatgata agagtgatgg
|
119461aaaagaacaa gaaaagcaga gtggaatcgg gaggcagggg cagtcagggc aagggtgtga
|
119521gatgaagtac ggcacggtca gggacatctt tgagagaaga ggaaggccag gcaccgtggc
|
119581tcatgcctgt aatcccagca ctttgggagg ccgaagtggg tagatcacct gcagtcagga
|
119641gttcgagacc agcctggcaa acatggtgaa tccgcgtctc tactaaaaat acaaaaatca
|
119701gccagaggtg gtggtgcgca actataatcc cagctactca ggaggctgag acaggagaat
|
119761cacttgaacc cagtaggcag aggttgcagc gagccgagat tgcaccactt cactccagcc
|
119821tgggcgacac agcgagactc tgtctcaaaa ataaataaat tcataaataa taaaaaataa
|
119881aaattaaaaa atgaagaagg tgagggtgag agacaagtgt acatcYgggg aaatggccag
|
119941ggcaaaggcc tgaggtctgg gacaggcctg gcaWgttctg ggaggaacag aaggagattc
|
120001ttgtgcctgg agtggagtgg gtgaggaaaa gaggaagagt ggagtcagag aggggtgaga
|
120061aggccctgaa tttcactctc agatagcagg ggcggtagcg ggttctgagc acagaaatga
|
120121taagaataga cttaaatttt aaaaagctcc ctctcctgtg gtgtatctag acaacagaat
|
120181attattcagc attaaaaaga aatgagctat ctggccatga aaagacatga aggaacctta
|
120241aatgaatgtt actaaatcag agaagccaat ctgaaaaggc Racatactgt gagtccaagt
|
120301atatgacatc ctggaagagg caaaactatg gagacgggga aacggccagt ggttgccagg
|
120361cattaggacg gagggaggga tgaacaggtg gagctcagag gatttttagg gcagtgaaac
|
120421ttctgtatga taccgtaaga gtggacagat gccattacac atttgttcaa acccattgaa
|
120481tgcRcaacgc caagagtgaa ccgtcatgca gactttgaac attgggtgat aatgatgagt
|
120541cagtgcagct catctattat agcaaatgca ccactctagt ggaggatgtt gatcatgggg
|
120601gaggctatac caggggtaca caggaaatct ctgtaccatc ctcttcattt tgctgtgaac
|
120661ctaaaactgc tgttaaaaaa tatttttttt taaagactgc ccctcaagca ctatcaggga
|
120721gaccactgag aagacaaccg cagcagttca cacaaaagat gagagcagct tgggccaggg
|
120781tagcagtggt gggtgcgggg agaggggatg cgggagaact gggcttatgt tgaaggcaca
|
120841gtcgacaagg ctcctgatga gcaggatgtc aggtgtgaga gacaagcagg agtcaaatat
|
120901gaccccaagg tcccttagac aaataaaggt gacagttaat gaggatcttc actagggctg
|
120961cagctcgtgg aaaagagagg agggaacaaa cacaagccat gttgtggcaa ctcaatggaa
|
121021aagatttgac aattcatctt aacacgggaa tggcggagaa gaaggccaaa ttctgtgatt
|
121081cattcaatgc ctttatcgag actcaactct acccagcttg ggaaaggccc cggggacact
|
121141ggtgagcatg accgcattgg ccctggctat cgatggaact taccaagcca accagcaatg
|
121201tattattcca ttattattaa tttaattgta gttttaataa attaatatat aaattaataa
|
121261atttattgaa tattaaatat gcacaatagg tatagcataa aatataaaca tttaatatgt
|
121321aatataaatt taatagaaat acaatttaat tttaataatt taatattaac taccaatgct
|
121381attatttcat aataggatca attcatatta caatactcaa tggcaaacat tgtattagac
|
121441aatgaggatt ccagacaaat aacaaataag agatggtagg tgtgaagtca ggtgcagtga
|
121501ctcacgcctg taatcccagc actctgggag gctgaggcag gcgatcactt gaggtcagga
|
121561gtttgagacc agcctggcca atatggtgaa accccatctc tactaaaaat acaaaaaaca
|
121621gccagatggt ggcacatgcc tgtaatccca gctactcggt aggctgagac acaagaatca
|
121681cttgaacccg ggaggcagag tttgcagtga gccgagatcg agatcatgcc actgcactcc
|
121741agcctgggtg acagagcgag actctgtctc aaaaaaagaa aaagaaaaag aaaaagaaac
|
121801ggtaggtgtg cacccttata atcctattca gtgagagttt tagaagtggc atggatagag
|
121861ggtagtggac ccatggggac agagcagcca tccgcctgaa gggtgaggac ggcatgggct
|
121921tgagggatgg ctgggcactg ctgggaaacg gagtgtgcag tcatggggac cggtgaggct
|
121981gggtgtgagg gtggggggtg ggcaagccgg actcacgtgg ccgtagctgg agcagacgct
|
122041cccacgtttc aagcctagac aatggactct tggttccatg gggacaagga ttcagactgt
|
122101tttgtccact ctgtgtccct gggaccctgc acagtccctg tgttcactag gctcaacaaa
|
122161ttcactttgc atagacagac agaagagagg gaagggaacc gaggtgaagg caataatgac
|
122221tccttcggaa gataggttaa gtcagaaaag aatttgggag cttcctggcc accatagaaa
|
122281caaggcagtc tgagactgag ccccggccct tgaggggagg atctggagcc aagccggtgc
|
122341tggagttctg gaagcgctat ggtgacagga acactctgtg gggtccccag caggtgYggg
|
122401aatacctgta tttcctggat gctttcctcc tccctggcat ccaccttctt ctcaaccccc
|
122461tcgccacgga gcaaggcttc cagcgtggtg ctctctgagg tgaacccatc cttcttcagg
|
122521ggaagctcca cttctgaaaa acaaagatag aaaggcaggt caggccacta gaagcaggca
|
122581gggcaggagg gacagtcctg gaggacacgc agggcccagg gctcctgagg aggactcggg
|
122641gcctgtgctc tctcctcctg gagggagagg aacactggag ccctgtccag cttttccatc
|
122701tccatttcat aatccagaga cagattccga ccatgcccac acccccagag gaagctgagc
|
122761cagagcagaa agggtgcggg gtRgatgtgg gctcacacgg ccatgcttct gcctctccag
|
122821ccatgacatc ggacaaggca ggcgtcagga gcgtggagcc cttattgcat ccacaaagca
|
122881ggggtaacaa tacccaaccc cacaggtggt tttgtaaggg gacatgtgtt catttgcggg
|
122941aaagtgtttc aaaaactcaa gcaatgcaca atgctggcaa ccaagtatgc tcattccctc
|
123001ctatcccagc tcttgtctgt caaccccaYg acctcctcat ggccatgctg gctgcccagc
|
123061tctgctttcc tccatgaaaa gctagttcag cctcagaaag gttgttctct tcaacccagg
|
123121gggaagtgag agcttcaaaa gccacgggaa gaggagcgac ggcgaatgcc tcacaagccc
|
123181cggatgagca gagtggccac tgcacagcca cgccacgacc tttttttctg aaggtatcag
|
123241gagtttgatc agctacctgg ggcttgagaa gagaagccct ggggttgcca gcagagaagt
|
123301ggcaacccga gccagccctg cccagaagag acaccagaga gaagctgaac cccttcctcc
|
123361aggtgtccca aactcctgac ctgacagagg gttggtgtgt ttctttcttt tctttctttc
|
123421cttccctcct ttctttcctt tccctccctc cctcctttct ttctttccat tctctctttc
|
123481tttctttctc tctcccttct ttctttctct ttctttcttt ctctctctct ctctYtcttt
|
123541ctcttttaga gacagggtct tactttatca cccaggctgg agtgcagtgg cactatcata
|
123601gctcactgca gcctcaaact tctggcctca agcaatccat ctgcctcagc ctcccaaagc
|
123661actggggtta taggcatgag ccaccatccc ctgctgtttt tttaattaaa gatgcaaacc
|
123721taaggtacag gagatcattc tgatttacta aaatatttct tcaacctctc ctctgatcct
|
123781ggacctcata cccccacact gccacagttt gatatgtggt ccttaccatt gcaccaggta
|
123841agctgggggc aggaactatg atgcagtggt gtcccagaaa acaggagaga tgaatggcct
|
123901gctcttttgg gggtattgag agtttagtgt agggactatt tacagagatg gggagaggtg
|
123961attaagggat ctgacaaggt aggttaaagc atcccaggtg ggttttgggc aggggtgagg
|
124021gtggagaggg gccattaccg ctgctgctat ttttggaggg acagagggag agtgcttgca
|
124081agaacctgga gatagcacca ttagcaSagc cecaggacag gagctatggc ttgcagaagc
|
124141caggaaccaa gggaagaaac aatccaacca ccctctccat ccatcctcca tcagcctgct
|
124201gcgtcctctc ccaagggcca accttaaaca gaagcgagag gggaagggag cccccttcac
|
124261acagcctacc gagctccgag cagggtgaag acggaaaagc atggatctgg aggggcaaat
|
124321ggaaagagca gcaccaccga gcctgctcca ctgggctctg tcctgactcc aacagaatcc
|
124381tacctgcact ttccacttcc tccaccagaa acagagggag tctgacYaat ccatgaggaa
|
124441gcggcaagcg ggcatccatt aaaactgaac aaatgcacac ctgtgggtga ccggccccca
|
124501gaaaaagaag gtgggaagga gaaacagcat ctaaaatctc ttgagaaaca aagtctttgg
|
124561gatttttcct accaaaaaag gagagcaaag gatccacttc ccatcaagga gcgctaccac
|
124621gaaatcagcc acctctgaat ccatctatcc attcaacaga tatttactga gcacctgcca
|
124681taggaccacc actgtgctgg gactagggac ataggaggtg aaccaaataa agacaggYcc
|
124741tgcctttagg aggcttacag tccaaagaga cagatagtaa atgcaaaata caaaatcaaa
|
124801atgcaattac gaattgtcgt aaatgttagg gaggaaaacg acagaatgaa atgtgaaaga
|
124861atataggtaa cggggtctac cttagatcag ggagtcaggg aaggcctgta tgatgaagtt
|
124921acatttaagg agagtgtcag acaaacagcc aactgtctgc tttaatgagt tcatggagta
|
124981catctccata gcctgctctg atgacatatt actctttctc ccaagtcaga aaagtcttcc
|
125041aaatgtctac tctaaagcaa ttagtgtgtg ctgtctcatg tcctgtcctc agtcaaaaga
|
125101gaacagctgg tcacaacccc tcaaacttat aataatcata tatacataga gttgaagttc
|
125161atattttagt atccccctta gccttcgcag cactaaataa atcctattta ttagtgttat
|
125221ttcccagaat ggtacagcat tttagagcta gaaaagacct tatagatcat ctaattcaat
|
125281catctcattt tgtagatgcg tcacccgaga ccctgaaaag ttaagtaaMc accaacagcc
|
125341acacagcagg atgagaatgc agctgaatga tatttccaag ttgccactga aatcacgaca
|
125401atggccccct ctcattgtat tcttattagt ggttgacagg cttaggctga gccctgaatg
|
125461agctttggta catccgtgta catgcagagg gcttggcaag cagcaaacat tcaaaactta
|
125521gcagctgtta ctgctacgta tcaatcccca ctacacccaa gagcacagtt attaacccgt
|
125581tttacagatg agggcagtgc agcttataga ggttgagaac ttgcttgata tcacacagct
|
125641ggtaaggggc aaagcccggc cttaaactca atctgccttc agacccagtc acctaattag
|
125701gctgcatgga ctccaccctg tctctctgtg gtccttcctt gaaaagtctt tttccaaacc
|
125761tttatgcatt ttcattacat tctgagactc actccRtagt tttcatattt caggataaaa
|
125821ggcagatctt taactgagga tgagggcagg tttgtgccat ggttttgggt tctgctctat
|
125881acgatcatcc ccgtgcaatg ttcaccattc tgcgacagta tctacccact atagaatgtt
|
125941ccatcaatag tgaacttgcc cctctcttcc ttctcctgct cttccttcct cctctgataa
|
126001atatgcctcc atcctgcttt cccataattg aatctactct cttggtcctc tttaaccaaa
|
126061ctttaccaga taggcacagt agaagaatca agagggaaaa cagaaccaaa tgggaaaagt
|
126121gaaatggaaa aagcaagaag ggatctccaa tagcatcaag agtccaatcc cttaaacagg
|
126181aaagtgaagc acagaaagat atagagattc ccccagggtc acagagacat gtagtggcat
|
126241cttgcttccc taattaccac aataRttgat ttgctcccat aggttctgcc ttcagacagc
|
126301cctggagtca atccctagcc ttgccacgta ttagtaaagg gaccatgggc tagctacgta
|
126361acctaagcct ccatttccat atgtggtaaa tgggtgtggt catagtatct atttcagtgt
|
126421tggcgaatca aacatggcaa tgtgctacat aaagaaacgc taaaagaatc cacacacaaa
|
126481aaaactagtg tgataaatag ggtagaagat gaggcttatc aacttttgtt ttattctatt
|
126541caaaacttag attcaaaatt agatcatata cgtaaagaat ctacaacatg gtaagtatcc
|
126601taaaaatgct agatgttatt ccctaagttt gaatagtttt gatttcaatg gtacagctgc
|
126661actgtccaac agaaatgtaa taccggccac ttatgtaatt tttaacttac tagtagtcac
|
126721atgtagaaaa aggaagaaag tcaggtgtca ttaattttaa taagataWtg tatccgatct
|
126781ggtatttcta aaacattacc attcaacatg aaatcaacat aaaaatatgg acgcaaaatt
|
126841ttacattctt ttatctgcat tgtcttcaaa gtctggtggg tattttccat ttagagcgta
|
126901tctcaattca gactagccac atttcaagag ctccatagcc acaggtggct accagctacc
|
126961ataatggaca gtgcagattt gcagcattaa aaataacatt aactatgact ttgcttccaa
|
127021aaaatggaaa gaattttact gtggttctta atgttgtcca cgtaatagct gccgagtgcc
|
127081attccaagag cagagttcta gcggatcact gcaaaccctg gttgcaaagc atgatgggta
|
127141aggcctgcaa ggtcagagtg aaagggtagc catccctccc tacaaacaaa cacagggtgc
|
127201actctgcctc ctgaccacag gaggtcccag aatgaaggag gaagaaaggt aacaggtcca
|
127261agcccttgca caatgtatgt cctaaacaca cttctattga gccctYaggg atttcattta
|
127321tccaatttta tttgaatatg gcccatctgg atataggatt taataattct ttgaaagtgt
|
127381actcattttg aacctcacac aaacttgggg cccacataac ccgacaggag ccattgaacc
|
127441tttaacatta aaagaaaatg gtccaaaaca cacacataat tcatctttaa attagcctga
|
127501ttttatacac atggatataa acccatggat cgttactctc tccRgagcgg cagcagctgt
|
127561cacccaagcc agccgcctcc ctgggccccc gtaagcagct ctgcctctac ttctaattgg
|
127621gaacagagat actccttggg tgacttccag cacgatccat cacaccagag acagcttctg
|
127681tgcaaaccga agcaaatcgg tttctaaata agaaaaaacc tccgagacaa acaaggattg
|
127741aagcatagaa agtcttttaa aaacaaccaa aaaaagcaca aataaaagca aaaaaacaaa
|
127801caaacaaaMa aaaaaaNcca cacacacaca cagaaatttc cagcaaagag caatggcttc
|
127861ttctctttag ggctacagac agggcagcca tcctcttggg tgcagatcaa agccacaagc
|
127921ttttgacaca ggtgccccaa gcctgccacc caatgcactg aaagcaaagc ttccactggg
|
127981ttgttggagc caccgagctc attaacagga tgcaggcgag atgagtctga aagtgcaaca
|
128041tgggagcaca gtgagtaatt aaatcccagg tcatttaaaa atgcaaacgc cacgaatgtc
|
128101atgagctccc caagcctctg actccttctc cttcgttatt tggctcagga tgaaggactg
|
128161gaaacctgca agtcgtatat ggattataat aaaatatgcc atatagaaaa cagattaaga
|
128221cagttcttct ttggggaaat atacaaggag aggagctgtc tgttagctgt cgagtttgca
|
128281agagatacca tctttcggga ggcagtgtgt tctgccaaca gacagactgc cccaagggaa
|
128341attgtggtga aacaccccga caaggcgcat ccatccgtcc atccatcatg ggctccctct
|
128401gatgcagggg cctggagata gagttatggt gcaaaaggga gggagaaatc ccacagacaa
|
128461tggcaaagaa tcctcctgct agatcatgag tgctcaattt tttttttttt tagctgcctc
|
128521tagtttttct tcaaaaatac aaacatgcag ttttctcgtc tgggtgctta ttatattgag
|
128581gagttaagct catcatattt ccttggattt atacatcaaa ttacacgaag gagaaaagag
|
128641cttaagaatc attatttcat ttatccccat cagactgtca gactcgtgag gagggagaag
|
128701ggagggaggt attgttatct ctcacctcac aggggaagag actggggagg gggatcagag
|
128761acctgatttc ctaagatggt ggcaggccca gggatccatc tgctcattcc ctaggggtgc
|
128821cactttcttg gctgcctttg actccctgtt ttgtgactca taaagctcga aatagatgag
|
128881gttcacattg aggacccatc acccaggctg caccctgcag gccctattac cacttgcttt
|
128941agaatctcag gatatccata taacaggagg actcatccct cccccatatg gcctctgctg
|
129001cacctaccct ctcaccccta agtagacacg ccaggatggg ttacggcatc cagatatcag
|
129061gaccacagat aagcattccc ccaccccgag atacagaaaa acacccacac tgcccaagga
|
129121agctcaccac tgagctgcca gcagaccagg taaatgcagc taccaggagg gtgagacggg
|
129181gagggtggtg ggagtggaca gagtgcgggc agcatttcca aaggcaaggt cggggaatca
|
129241ggagaggctg gtcagatggt acagagtgtc agtcagacag gatgaatatg ttctggagat
|
129301ctgttgtaca gcatggtgac tccagttatt agtaatgaaa attgctaaga gagtcaatct
|
129361taaatgttct catgcacaca caaaaaatga caagaatgtg gagtgataga tacattaact
|
129421agcttcattt agtcatttca caatgtatat atatatttaa acatcacact gtatgccata
|
129481aatatatata acttttattt gtcaattatg ccttaataaa gctcggaggg aataaaaaag
|
129541taaataataa aaatgcaggc tgggagcagt ggttcacacc tataatccca atattttggg
|
129601aggcgaggtg ggtggataac ttgaggtcag gagtttgaga ccagcctggc ctacatggtg
|
129661aaatcccatt tctaccaaaa aaacacaaaa attagccatg tgggatcgta cgcacctgta
|
129721gtcccagtga ctcgagaggc tgaggtggga gaatcgcttg aacctggaag Sgggaggttg
|
129781cagtgagcca agatcatgcc actgcgctcc agcctaggtg acagagtgag actctgtctc
|
129841aaaaaaaaaa aaaatgcata gtgcaaagaa atacagacaa ccagaaagtg caaaaagctg
|
129901ctctggggtg aactctcagc tccattaccc taaagcacac acttggcctt gatctcctta
|
129961tctgtaaacc tgggagaaca aaacccactt cccactgttg ttatggggcc aaaggagata
|
130021atacatatga agtgtctggc acaggtgaga tgctcaataa Statgagctc ccttctttcc
|
130081acctcctaca gtttccctct ccttgtgctt ttcagcaaaa aaaccctcac ctttctgaca
|
130141ctctaagacc accagatgtg gtgagtgagg cacagctaac cccaccatgg gcatgagccc
|
130201agggaggatg gaaacaaacg gaatctgagg caggtaacag gatggaagag gccaagaatg
|
130261agacgcagct ggaaagcaga cgctggtgct gctccaagtc cagggtggcc attgctcctg
|
130321gagcttcggg ggRaaaatca tggcagagcc acagtggaag ataccctgct ttatcccttc
|
130381atttggcaag taattatcaa gcacctacta tgtatcgact ctgttctagg tgctggggca
|
130441atgactctga agaaaagaga caaaaatccc ggccctcata gaatttatat tctagcaaga
|
130501gagaaacaat acatgaagca aacaagtgaa accttcagtg tgacagatgg taatcagtgc
|
130561tttggaggaa aaacagagcc aaggaggaga agttggagtg tcagggtgat gggagggggg
|
130621ttacactttt aaatgtggcc aggaaagtgc aagcctgaag gaagagaggg agggggctac
|
130681gctgacatcc aggcaaagac gttccaggca aaggggcctt cagcacaaaa gctctgaagc
|
130741cggcccatct gcctggagca cggtgagcca gggggatggt aggagaccag cttggggagc
|
130801tacaggggca ttgaaggcca tgtaggcacc tgcaagaatg ttggcgtcca ccccaaatgc
|
130861aatggcaagc cgctggaggt gttgagcaaa gcatgatata atgatgccta catgttaaca
|
130921gaatcactct gagaataagt gaagggggtc ggagcagatg tggggtgacc agtgaggagt
|
130981tactgcaaaa tgtatgtcgt ctcttaatga gtttggtgct tggggaggga gctatgcacg
|
131041atatggacag agctctgtcc tcatggtact aatattgtgg ttctcagatg tgtcctgggg
|
131101gcagtaagca ctggggagca gtgccctgag cagggggctt ccccaccagt gaaccaggat
|
131161ggaggccaag tggagaggct ggtgtcaatg caaagtgggc aaaggtgtga agccacacca
|
131221gggtgagtcc acggaggaat ggctcttcaa gaagaaagtg gaccagccca ggccaagggc
|
131281agggaaaaag atctagccac atgggcctgg cctggcatac catggtttaa caggtgtagt
|
131341aaaagcagag aggaggcctt cccagttcat ctctgtgccc tgggccatgg gtgcctcggg
|
131401gctgagttct gggacatagg agtgaggtcc tgcaagctgt ggttctggta aaggtgggtc
|
131461ccacggccaa gttctaggtc atctatagac tggggccttt taaaaggcta taagacagag
|
131521ctgggcatgg tggcgcatgc ctgaattccc agctactcag gaggctgagg caggaggagg
|
131581atcacgtgaa cacaggagtt caaatatagc ctaaggaaca cagcaaggcc cgtctctaaa
|
131641aataaataaa taaataaaat aaaatgaata gactctaagg cagaatgagt tgccattctg
|
131701ggccagatgg cacacacttt tccagcgggg cagYgagctg tctgcagcaa attcattttc
|
131761ggtgttgggg acgggaactg tgttgcRgag acccacccag cagtgcagtg tggaggtaga
|
131821atcacagtgc ctcctcacac ttgccaagtc ctccaccctc catcccacac gcctctcaga
|
131881ataaccccgc aaaatcacca tgacccacat ctcacagatg aaggactgag gcaggagtgg
|
131941ttaggaaatt gtccaaaatc acacagccag tggctggagg gatctagact tgaacctagg
|
132001cctgtgatcc ctgtttggtg cctgtcctcc tgcagagcaa ggatatttgg acagggaagg
|
132061cccctacaac ccaaaaccaa acagccaaga tggcaacact tgggcccccc aggccaggct
|
132121gggaaccaca agggaagcca agctcagcca ccccaggcct ctcctctctg gcggagcctc
|
132181cctcatctgt gaagcagaga tgatgagagc taagtcatgt tctccaaggt taagatcaaa
|
132241caccagacat gtctctttcc ctcatccctt tagaaatctt tactgcccat gtactatgtg
|
132301ccaagcctca tgctgggtgc tagggataca gatgaagaaa cagatgggcc ctcgccgtca
|
132361agttgtccac ctcccagtgg gcagaggtac aggtgagcag gcaatggcat aactgggtga
|
132421tccctcagac tcacaactca tgctctacac gtggctctgc caggtcccac tgcaaaacat
|
132481gaccgtggac actcagcagc agccgtgcca ctgtcctgcc cactgcctgc tgccagccca
|
132541cctcctcggc cagcccaagc tcccagagcc ctgcagaaca ccagcagagc tggggaacac
|
132601gagcagagct gaagtcacac agacttcgtc ccYcagtccc tgctcctttc ctgagacgga
|
132661caggaaggca aaaggagcag gtcccttcca gcacgtaata gccacagcct gagtgggggc
|
132721tgcacgccct gcccacctcg ctccagctcc ccttctcatg aggccaacca gagctgacga
|
132781agctgccggt gcaggcctcc agatggatgg ctgcaggctc tgacactgca ggaaagagat
|
132841aaatgactgg tcatttcccc ctgatgcact tgaaggcatc cattctccca gccgtaccaa
|
132901gctcaggcaa cccccaccgc ccagagacag ataagcactg acagatgggg gtgggagccg
|
132961gagcgtcctt ccccctcgga aggacacagc cagactcctc tgcaggccgg gagaaggtcg
|
133021cgttgtccat tggctcacac ctggctcgag gctccgcggg tcccttcctc catctccccg
|
133081ttcttgccca cccccgcctg gctcatccat ctgaagagca cacggcagag ggggaaggct
|
133141gggggcagaa ggagccgctg acaggctcat caatctcagg ttacatgctt ggcacctcgg
|
133201cgttccttaa gttgttcccg gattgggagg gtgtcgcagg agccaggggc actgtcttga
|
133261ggagaagaga aatcgcaccg aacatcagag agcaaatggt ggagaagcct ggagactatt
|
133321aaaatgtggg ccatgtacaa aagcagtagg gaactaatta agatgcagga ttttcaaaag
|
133381ctggggaagt tggccgcagc ctgctcccat ctgtagagtt ctggcagttc agcgcagcag
|
133441ggacagcacc ctgggtgggt gaagtaggcc tcaccacccc tgctcgagct ggccagactc
|
133501aagtccctcc gcctggacca cccctttggg agatacccct ctgcaggtcc ctacgacttg
|
133561cttgttggcc agcctgtggc cctctctgct ttgggacacc ttaagccact gtcgtcttcg
|
133621gggtgcatgc cctcttgtct gagtttcccc caacgacatg ggatgggggc gatcatcctg
|
133681gtcgttcatc cccagtcatt gaaggactgc caaaaacaga aaaaatacaa gagaaagaac
|
133741actatccctg gctgccctcc ctcccatcac cctcggaatt cggcaagggt ggcaaagagc
|
133801caccctgctc cccaagagtc ctggagcaga agggatcgac aaggcctcag gtgcattcca
|
133861ggtacaggag gagcgtcaac tgtaaagccc ttttcatctg cgggtccagg ataagtgagt
|
133921gtgtcgggcc ttcaagcaac atggcagcag ctccagcagg ctccccatag ggagcatcac
|
133981caggatcctg gcatcaccag gatcccctgg gaaattagct tcctaattct gtgccgcagt
|
134041ttcccaacct ctaaaatgaa gataatatct gtcctagacc atggggaccg aaggtctggg
|
134101gttgaaagat gctaaattga tctaagcaga ctatctgggc atttacttca aggggacaca
|
134161agtaaaagtt tgttcccagc ctttgtcttt tcttcattca aaaaaaaaaa aaaaaggaaa
|
134221agaaaaagaa agaaagtgaa gttaaaggcc tcttttttaa tcagctggct tttgcccaac
|
134281atctgctgtg ctcccaggcc ttctggtgga tatttactct ccacctttct cttctgccag
|
134341ctccactccc ccttcacaag gacagagccc ttttcctggg gagatggtcc gggggaggcc
|
134401ccttgctggc accaggcccc tgcccaagtc tttgtgttgt agaattgtga tgtctacatc
|
134461atgaaacacc ttgcattcgc ctctgtggcc aagtgcaagc tgcagagaac actgaactca
|
134521attgtcagtc actggggaga aataatgttg tgtgtgttgt ccttcagatg cccaggcaag
|
134581taggaggttg caagatgttt attcaagact gactagaggg gtgacatttg gcaggagaaa
|
134641cacataggtc cagggacact gagaacactt gcaaattcca aagagttctt cccagatctc
|
134701aggcccttcc tatccccatg cagacagatt tttattttca gcaaataata aagaaacaga
|
134761agagggatgg tgcatttacc acactgaagg ggtgaggaca gcaggactgg gagtcactcc
|
134821aggagggaat aatttcaccc aggaacaaat gactcgatgt cagccaagac ccagctcccc
|
134881actttttttg agccagggcc tccctctgtc acccaggctg gagggcagtg gtgcaatcat
|
134941ggctcactgc agccacaacc tcgcggactt cattgatcct cctacctcag cctccctagt
|
135001agtgtcaccc tacaggtgcc caccaccaca cctggctaat ttttgtattt tttgtagaga
|
135061caggttcttg ccatgtcacc caggcccagc tccccacttt ccagcctgaa aggtccactc
|
135121atcccacatg agcaaagtgc ttcgggggac tgaatcagaa aaggatggtt ctgtggcact
|
135181gtcctcagat cttctccaac agccctcaag attcttgaac gtgcaccccc cactctttgc
|
135241cctgacctgg tttcctgaca cagctccgca gacctgagSt cagagaaaac tctgaccctc
|
135301gttacccctg gacttcgttg ctgaaacctg cccatcactg ctggactcag gcagggacag
|
135361aaaggaatac aggagggaca agctgaatgt tggcataaat tttttgtgac atctcctcac
|
135421tgtccatagg agagtctgac gtggaaagaa actcatgcct tgagacaatt ctgctccagg
|
135481ccagtggccc ctcagtctct tgaagagcag gcagactatt ctccctcttc ccggaggaga
|
135541tgaggacatg tcagggtgtg ctgacggcag aacccaggtg ggcttcaaca gtactaggca
|
135601aaactagatt cctgagcatc ctctgtcaag gggaggtcac accaggaggc tgggagggaa
|
135661gatgaggaaa agacaggcat cctcaggggg tgggtgtgga ggggcaccWt gggtgggtgg
|
135721gttggttggt tgggttcttt ccaacataac tcagccttcc agtttccata aatttaaaga
|
135781gatgcaaccc aggatggaca aattatcgtt cttcagcaag ttttgcccag aggattatat
|
135841acaatgttgt acaatttgct ttttgttgtg caatttgttt tttttcgcca cttagcaata
|
135901tatctttaac atctctccat atttttttta ctcattcttt taaaggacaa aataatattc
|
135961cattcataga atatacaagt actatatatt taactagtcc tcatcaatgg atcttctgga
|
136021agtttccatt ctttgttgtt attacaaacc atgccacaat aaaaaatata tacccaatat
|
136081atattatatg catatattca tttatagaat aagttcctag caatagaatg tctaggtcaa
|
136141agagcatgtg tgttttaaat actggtaggt actattcatt gtacctcaaa aaggtcatac
|
136201caattccRtt gcaatgtgta aaaaagagcc tctccctcca tctccatctc tgtttccctc
|
136261acctgctccc ctctccttgg gaaggtcagc ctcagtccac ccagctaatg atcctcacct
|
136321cctaggaatt tgcagcaaat tctccagaga ctctggccaa tgactctatc ctgagtcacg
|
136381cgcgaagtat cagccaaaaa actgagctct ccttgagccc aaatcaaatg gaataaaaat
|
136441aagagatagt tattttaaaa tactgtccga gttagccctg ttaaccctcc tgagggagga
|
136501cataccccca aaaaagggag gagtcctctc aagtggaaac tgcattttat gaatgatgag
|
136561ggcagagcct ctggaagttg ggcaggttgt gccctcaaag ggacccccac caggtgcaca
|
136621gaagaggggc tgagatctag ctcgtgctct actaacccac cagaaagggc atcatacgtt
|
136681ttgtaaacgt ccacccccca gggggcacca ccctccactt ttgcacaaac aaaaccatat
|
136741gtgctagtca aggccctgga tgaagtcact cttctgaaat tttggcctgt gcaaaaaatt
|
136801caaatgcaaa cttgcatcac ctctgggaag acagtgggta catttctttg gctgcgctgt
|
136861ttctcattct ctagatgggc cctggctgct tggaggtacc aggctgaggc tcgttaccac
|
136921tgactccagg gcactccgac ggcctcttca ttcaccaccc gcagctgcag gctggcatgg
|
136981tggtacattc tgggagccag gtgcagcccc ggctgttcag actcagaaga ggattgggaa
|
137041atgacaagca tctgccctag ggtttgtggg ggttgtttct gtgtttttag Yaggcctagt
|
137101agtaggtctg tttacccaaa gaggggaaca agttcctctg agaaggtgct ctgccatgtg
|
137161acagtcacgc attccagccc cggctgttca ttgcttctca gcatctgggg gctggtgtgg
|
137221aggaataagc ctgccttggg ggaacccaac ttttcccccg agggcggata attgcaaagg
|
137281ccagcacctg tctctgcaga tggggtcctt ccccgggacc ctgcccatcc ctggggtgga
|
137341ctttcaccac tggaaacctg gtctagccac ttctgcctca tgcttgggca gaggctgaag
|
137401aagcctctca aatgatcaca gatacaagac gccatgtgca ggtggggact tggctatggc
|
137461aaaccgctag ccctaggttc ttcctttccc ttcccctcRc atgttacggc aggcccgaca
|
137521acggggcatg gccaaagcag gctgtgaact cagctgctcc acgttcaccc acaggccagg
|
137581cataaacact ggcaggcccg tgtgcccaaa gtaaatgttt ttaggcagaa ggcacaaaca
|
137641ctcaagaaat agctgcctgc ctcagtccca ccaacatggg ctcctcagat acatgagcag
|
137701cacaRcaaat tcttcttggc tctgtMcaca gtctgatttc tctcacctct aaaatgggct
|
137761cacaaccctc ttacctcttc cttccctctc taccttccag ggctatggta gggaccaagg
|
137821agctgacatg aaagaaaatg ctgcatgaac tacagcatgc tcttcggact ctggttatga
|
137881tgatgatgat taaccagagt gtcccatccc ctgggtggca gcaattggtt gtgggggggt
|
137941aatRacccca gccagctaat ctgtccttcc taggtcttct ctgccacagc tgttgagggt
|
138001gactgccttt ctgctgggtg tggtatgtgc tgagactgga gctgctggca gccccctcac
|
138061ttaccctatg aggagaagag agtgttaaag gtacagagag actggctggg tgtgatggct
|
138121gatccctata atcccagcat tttgggaggc ccgaggcagg aggattgctt gaggMcagga
|
138181gtttgcaacc aggctgggca acatagtgag acccccgtct ctaNaaaaaa aaaaaaaaaa
|
138241atagctaggt gatatggttt ggctctgtgt ccccatccaa atctcatctt gtagctccca
|
138301taattcccac gtgggaggga cccagtggga gatgatcaaa tcatggggga gggtctttcc
|
138361catgctgttc ttatgatagt gaatgggtct cacgagatct gatggtttta aaaacaagaa
|
138421tttctctgca caagctctct ctttgactcc tgccatccat gtaagatgtg gcttgctcct
|
138481ctttgtctcc ccagccatgt ggaactgtaa gtccaataaa ccagtttctt ttgtaaattg
|
138541cccagtctca agtatgtgtt tatcagcagt gtgaaaacag actaatgcag taaattggta
|
138601ccagtagagt ggggcattgc tgaaaagata cccgaaaata tggaagcaac tttgcaactg
|
138661ggtaacaggc agaggttgga aaagtttgga cggctcagaa gaagacagcg aaatgtggga
|
138721aagtttggaa cttcctagag acttgttgaa tgactttgcc ccaaatgctg atagtgatat
|
138781ggacaataaa gtccaggtta gggtggtccc agatggagat gaaaaatttg ttgggaacta
|
138841gagcaaaggt gactcttgtt acattttacc aaagagaatg ggggcatttt gcccctgccc
|
138901tagagatttg tggaatgttg aacttgagag agatgattta gggtatctgg tggaaaaaat
|
138961ttctaagcag caaagcattc aagaagtgac ttgggtgctg ttaaaggcat tcagttttat
|
139021aagggaagca gagcataaca gtttggaaaa tttgcagcct gacaatgaaa tagaaaaaaa
|
139081aaatccattt tctgaggaga aattcaagct ggctacagaa atttgcataa gtaatgagga
|
139141gcccaatatt aatccccaag acaaagggga aaatgtctcc agggcatgtc aagggtcttc
|
139201acggcagccc ctcccatcac aggcctggag gtttaggaga aagaaatggt tgtgtgagcc
|
139261aggctcaggg tccttctgtt atgtgcagcc tagggacttg gtgtcctgtg tcccagctRc
|
139321tccagctgtg gctgaaaggg gccaacatag agctcaggct gtggcttcag agggtgcaag
|
139381cctcaagcct tgacaaattc catgtggtRt tgagcctgtg agtacacaga agtcaagaac
|
139441tgaagtttgg aaacctctgc ctagatttca gaagatgtat ggaaatgcct ggatacccag
|
139501gcagaagttt tctgtagggg tgaggtcctc atggagaacc tctgctaggc agtgtgaaag
|
139561ggaaatgtcg ggtgggagcc cccacacaga gtcccaMctg gggcaccacc tagcggagct
|
139621gtgagaagag ggccaccatc ttccagatcc cagaatggta gatccactga cggcttgcac
|
139681cttgcacctg gaaaagccgc agacactcaa tgccagccca tgaaagcagc caggagaaag
|
139741gctatactct gcaaagccac aggggtggag ttgcccaaga tcatgggaac tcacctcttg
|
139801catcagcatg acctggatat gagacatgga gtcaaaggag atcattttgg agttttaaga
|
139861tttgactgcc atgctggatt ttgaacttgc atggggcctg tagccccttt gttttggcca
|
139921atctctccca cttggaatgg ctgtatttac ccagtgcctg tacccccatt gtatctagga
|
139981agtaactaac ttgcttctga ttttacaggt tcataagcaa aaggacttgc cttgtcttgg
|
140041atgagacttt ggactgtgga cttctgagtt aatgctgaaa cgagttgaga ctttggaaga
|
140101cggttaggaa ggcatgattg gttttgaaat gtgaagatat gagatttggg agggggcaag
|
140161ggcagaatga tatggcttgg ctctgtgtcc ccaggcaaat ctcatcttgt agctccccta
|
140221attcccacgt tgtgggaagg acccggtggg agatgactga atcatggagg tgggtctttc
|
140281ccatgctgtt ctcattctag tgaatgggtc tcacaagatc tgatggtttt aaaaacaaga
|
140341gtttctctac acaagctatt tgcctgctgc catctgggga agttgaggct gcagtgagct
|
140401gtgatcgtgc cactgcagcc agggtgacag agtgagaccc tgtttaaaaa aaaaaaagaa
|
140461aagaaaagaa aaaaaNgtaa gaaagagaga gagaggtaaa gagagacatg tagccctcac
|
140521tacgctcact atgcttgagc acctggatgt agctatgcct gaagccagat aaaccctggg
|
140581atttactggt acatgagcca actttccttt ttctgcttaa gatagtttga cttgagcttc
|
140641caatgtttat gactaaagga attccaacta tctcttggtt attttaataa tttatatatt
|
140701agttttatga tcataaaata aagtttttaa gagaagaagc ctggctaaag tttctttaag
|
140761ttagtatacc tatcaatagt atgaggaagc agaaaaagta ttgaacaRgg aaatcaggca
|
140821acctagattc tctgctggac ccacaaaaat tgctgtatga ctttgaacaa gtttcttaaa
|
140881ctgtctagac tccaataaaa taaagaatca gagttagtga tatctaaggt atcgtatagt
|
140941gctaaaagtc tttgcttcta taaaagaaga cctaattagt ctgatataaa ttgttcttaa
|
141001ccaagacttt ttatagaaat gttaagaata aagactaata atttaaaaca tgtcaagcac
|
141061ttataataaa accctttaaa ttgacaactt acatatgaga cgtcctcata tatacatgca
|
141121aaatattcat tgcatcactc actggttaaa ttggaaaatt tagaaacaaa aattgagaac
|
141181agcccggtta gacaaattca tacaatggaa tattatgtaa ttacaaaaac gaaatgaaga
|
141241aactttatat tttgctgtgg acaatatcta aggcacattt ttaattgaaa agtgcaaaat
|
141301ccaaagtggt tgtgctgtgt aaaaagagga gggaaagtca gatagattta attcctggtg
|
141361caWgcatgga ttatctcttg aaagaatctc aaaaaaaaaa aaaaaaaaaa aaaaaacctg
|
141421ctaccactga ttacctttgg agagactggg tcttattttt catgatacag tatatccttt
|
141481tatcttttga atgtcaaaat atgtgactgc caggcacagt agctcctgcc tgtaatctta
|
141541gcactctggg agaccgaggc aggaggatta tctgaagcca ggagtttaag actagcctgg
|
141601gtagcatagt gagaccctgt ctctacagaa aagacaaaat tagccagaca tggtRgcatg
|
141661cacttgtagt ccccacacac tgaggaggcc aaggtggaag gagtgcttga gctcaggagt
|
141721tggaggctat agtgagctca ttgcaactac tgcacaccag actgggcaac agagcgtgac
|
141781cctaccctct aaacaaaaat taaaaaataa aattaaaaaa actgtacatg taactgtatt
|
141841acctactcaa agtcaaataa attttggaag tttttaattt aaaaattaca taaggctttt
|
141901ttggtactta tggtcatgtc agggtgacat gtagcctagc tacctgtaag tcttcgagac
|
141961cagcatttct cacacttcat cgtgcattct gaggatgcac tccaggggat cgtgataaaa
|
142021tgcaggttct gatgcagcag gtctggagca aggaccaagc ttctgcacgt ctgacaagct
|
142081ccaggtgatg ctgccgctgc aggccaggac cgcactttga atgtaggtct agaaccacac
|
142141tgatcaatac ggtcaccact agccacctgt ggctactgag tgcttgaaat gtggctagtc
|
142201caaaaagaga tgtggggatg tgtaaaatac acaatggaat tgaaaaagag tatcaaaaaa
|
142261gatcataaat gattttatat cgatgacatg ctgaaatgat gtttttgata tgttgggtta
|
142321aatggaatat attattgaaa ttcatttccc ctgtttcttt ttcctttttt taatgtaacc
|
142381actagacaaa gtaaaacaac acacatggct tgcattatat ttctattgca tcatgctgtc
|
142441taggagaacc tgatctccta caacctgcaa caaggcaggg gttgggacaa ccttgtcatc
|
142501accctggagt atttgcaagg gtctgtaaat tggtataagg acactggaga cttgggagag
|
142561agcacattga agaatctggc acccactcac ccctaacaaa taaaacttct atttaagtga
|
142621aatacggatt gaagcgaaca atcaaagcag tcgtaaccct ggaactgtag gtagagcttt
|
142681tgcagagcag agtcagccta agggaccagt gttgMaagga aggagtgagg tacctttgcc
|
142741aggcagccag gcttgacagt ctgcaatgct gtggtgacag tgggaggaag tatgtcaact
|
142801ctacttgcac cactgaacag cactgtccct accaccctga gtcacatccc agcctggcac
|
142861cctcaaaaac aaagatgcgt ttaaagctaa gggcctgggg taatcacttg gcttgctgca
|
142921acacagacac aggtctgaag acagccaaat agtcagaagt gtaatattag atcagcatag
|
142981gccaggcatg gtggctcatg cctataatcc cagcactttg ggaagccaag gcaggcagat
|
143041cgcttgaggc caagagttca agaccggcct ggccaacatg gtgaaacact gtctctacta
|
143101aaaacacaaa aattagctgg gagtggtggt gcacatttgt aatcccagct actcgggaag
|
143161ctgaggcagg agaatcactt ggactcggga ggcagagtct gcagtgagcc gagattgcac
|
143221aactgcactc cagcctgggc aacaaagcta gaYtctgtct caaaaacata tatatattag
|
143281attagtatag acataacgcc accaattcct tctgtgtggc cacagagcaa tctgcatcac
|
143341acgggtaaat tgtaatctca aactcttcca tcctcatcca aggtaagtgc aatttttagt
|
143401gaattggccc ctttttgtgt aagatgctcc aaagctcata cagggtaagg ggtagagggt
|
143461ccacggtgta ttatcttctc cttagaaaca tacaaactgg gccaagattt ctttacttga
|
143521ggccacaaga aaagtatcac atgacccgaa agagctgcac atccttcagt tctgttggga
|
143581aattcatcct gcacctgggc tggggtgcag cctttctttc ctccctgggg tggcaaaggg
|
143641aaggcatgag acacccagag gggagaaaag ctcaggtgga cacgtggtca tgtttctact
|
143701cagcaggcac agaggtgcac ccttaagcat gatgtgggca tgttccctct cccagaaaac
|
143761ttagctctat ggacaaagga gcaaaccaac cttgtcctgg gcccagccca gtcctcccac
|
143821ctttcccatc acagacccag ccaagctcca gagggcactg accaggtttt atctccagca
|
143881gccgcagttt tggatcttca ggtgggtgca Rtcgtctctt cttgcgccag cagcgggcag
|
143941ggtatgtata cagctggccc ggggcaaggc ctgtggacag agacaatata aagattaaag
|
144001gctccaggct ggaaggggcc ttggaaacta ccctgactaa cccYgtcatt cacaaggaga
|
144061ggaagctgaa gcccagagag aagtgacttg tcaacatcac aaagctgatt gctagtggtg
|
144121gcaaggctga atctaggtca tctgacccca ggaccctggc tctgtcagct ccaccatgct
|
144181gttcagcaag cccatgccaa cgagagccat tgccttcacc aaaaccaatt ctgctctcct
|
144241gcctggagag atcaccaact ggaccttcag acaagaagga cctttgcagt gtctccaaag
|
144301cagtggatct ctatccactg cccctctatc ctgatccagg ttaagcaggt tcccttcaaa
|
144361acggagcagc agtcagttgg cctactgtat ggacagcctg ggttgagaag catcgcaaag
|
144421agacagaacc aaaaacacta gatctactca aaggcgtctc ccacccactc ccagctgctg
|
144481gcagctcact gtaggcaaat ggaggcttgt gtagccccca tgagaacata aacccactct
|
144541ggtgaccagg ccacatgacc tgcagagccc gcacacctct atatccccgc ctacatgcct
|
144601gggccttaca aaaaaaaaaa aataggcagg aggccagggg ctgggcttac gtgccaccct
|
144661gtgtgtgtgK cctttgacac caacagcatc actgtcatgc caagcaccat gaggagcctt
|
144721cctgctcacc cgacaacaat tgtgtgtggc tctggtggca gccacgggcc ttagaggaac
|
144781agggacttct ccatgccagg tcacagacta ttcccaggga aatggggcgg ggaagaggct
|
144841gaggggtgag gaggcaggta tttgagactg gctaggtaat tttcagactg gctaggtgat
|
144901ttgtagtcct gaagagagtg tctgataccc cccataataa accagcaagc caacaaatcc
|
144961Ytaataggaa gaaaagccta atgaagacag ggactttttt gtcttgttct tgtcagaagc
|
145021cccagaatca gaactgtgcc tgacacagag cagaaccaaa ctaaatactc attgaattaa
|
145081tgaatgaata tattgcagct tcctttaaaa tcacaactct gtcttctgca ggtaaatgtg
|
145141gcacatggca gctgttggac gcaggcggcc taccacaaaa gtgtcactgt gcacacctag
|
145201gaccatggat tcagaaaaca tcagcacctg attcccatct gccgtcttcc attttagggc
|
145261ccttaaaagt taagaaggga aactggcttc atttttcacc tttgcagaga aaatctatgt
|
145321aactttcatt gctatatact cattcattca ttttcatttt taccagtcaa ctctacccat
|
145381ttattgggat ggggccaaaa caaagtcaat tatcccagca ttaaaggaac caaaatactc
|
145441aggtctcttt atgtttaatc acacagctgc tccacaggtc acaagattgt gaacaagttg
|
145501gaggttctga ccaccccacc cctttggttc ttagaaacta gaactgacct ggactcagaa
|
145561atgtcagaat tgaatgacca ttggccctgc tgttcctggc tccaggggac tcatccaccc
|
145621agatccaaag catccaagag ggactccaga agtggaggcc caggcctgag gccagagccc
|
145681cctgcacccc ctctcccacc atggccatct ctgggcctta ggtttccttc gttccccagt
|
145741ggctgcttta cggtgcttcc aacctaatca aacacaggta agtaagagtg agctggcccc
|
145801caccagcacc ctccaaaggt ctacgtggca agagtgcaaa agtgtccaca cttgtccagg
|
145861tcctacaccc tccctgagac agcagtcact gtgcttggtg gtcagcggta ccagagaagc
|
145921cccaggccac tctgcttgga gctttagacc cattcttctg ggagaattca ttttagcaac
|
145981tagtttgaat ctccagaaga aggggctgtt tttgttccat tctttctctg ctggattgga
|
146041gacactctgc agtgcaaagg aagagcacgt gagtcctggg aagcatccta acacctttct
|
146101gagcctattg cctcacctgt aagataaggg cattgataac attaatacct acctcctggg
|
146161gctgttatgg ggatttgctt atattcaaga gaaagctctc tatatccaca aagatgacaa
|
146221atgtcagttg ttaattgtca tgagttagct gacctagtct tggactccac actcatgcaa
|
146281catgacagac cccctgcccc atccaccatg ctgccacttg gttctttagc catgaaggtg
|
146341gaaacaggct tctttttgat gtctgctttg aatccacctc atcacaacaa gcaaatggtc
|
146401gcaagagctc tcttggagct ccctggcccc ttccttgccc tcctcaacag gctgacaggc
|
146461accagggttc ctttatagga aaaacacgtt cagccctgga gttccactta cagagggaag
|
146521agcagggccc catgagactt atgttgttta tctcagaaca ggaggcagat aactcaaagc
|
146581atgtgtgtgt gtgcatatgt gtgcgtgcat gtScatgtgt ggtagatgga ggtggggaag
|
146641gaggatggag tcacagctgc tgtcagggaa attaaccttg gggagtgagc ctagggctgg
|
146701ggaggggaca tgaaggaggg gaaacaagtg gccaaagaca agaggggaaa ccagtcctcc
|
146761ctggtaacca aggccactgc cacccctcac ttcacatacc ccactgagca aactactttt
|
146821ctgttacttt gagctgcaac tcgagctaca acattcctgc ccatgtgtaa gcacaaatgt
|
146881gatgcacaaa gacacacaca cacaatcaaa aactcacaca cttgctggga gaactggctc
|
146941catggaaata cctggcattg aaaggcttga tgcctttatg gttagcagac tccagacaaa
|
147001tacagctggt tatgcacatt gcacaagttc agcaggtgga tcctgagggt tctgggcatc
|
147061tctcacagac aaagcatgag ctattcagaa tttagaagat gaaatgggag agaaaagaga
|
147121gggaagagtg gccgggtaca gtggctgacg tctgtaatcc cagtactttg ggaagccaag
|
147181gccagcagat cactgaagcc caggagttca agaccagcct ggccaacatg gtgaaacctc
|
147241atctctatca aaaatacaaa aattagccag tatggtggcg catgcctgta atctcagcta
|
147301ttcgggaggc tgaggcagga gaattgcttg aacccaggag gtggaggtta taggagctga
|
147361ggtcatgcca ctgcactcca gcctatatga cagagcaaga ttctgtgaaa gaMagaaaga
|
147421cagaaagaaa gaaagaaaga aagaaagaaa gaaagaaaga aagRaagRaa ggaaggaaRg
|
147481aaggaaaNaa agaaagaaaN gaaaaaaaga aagaaagaaa gaaagaNaga agaNaagaga
|
147541agagaaaggg agagggaaag agggggagag agggaaagag ggggagaagg ggagagaggg
|
147601agagaggaga gaagagggga agaaggggag agagggagag agggacagag ggggagaaag
|
147661ggggagagga aggaaggaag gaaggaaggg aggaagggag agagggaggg agggagggag
|
147721gggagaagaa tgatatggga taggaacagc aattgaaatg gggaagaaaa aaactgaagt
|
147781agtttcatct ttccccatcc agagctgaac tgtggcagtt caagcccccc agggaaaggc
|
147841tctctctctg caggatctca gagaggtgga cccacagctg cccctgaaac ttcctttcaa
|
147901tggagaattt attatgtcac aggacacagt gtcccactgt cggccaactc ttactgtgat
|
147961aaagagattc accatgacct tattttgaat caaaatctat ctccctataa gttataccaa
|
148021tttgtccacc ctctgttcca acagcaaaca gctacatccc aatcctgcat cccatatatc
|
148081tgcttgggtt tgaagggcag ctaaccaaga agccgaggaa ctaaagagga ataagagttg
|
148141taggaaagag ttagtgacta cccctgctca gaaccgggta acaggatcaa agtttccaaa
|
148201tagaaaatga caatacaaca atttaaaata caatttaaaa aaatacaata taatacctat
|
148261ttacatagca tttacattgt attaggtatt ataagcaatc tagaaatgat ttaaggaata
|
148321tgggagaatg tgtgtaggtt atatgcaaat actatgccat tttatataag ggacttgagt
|
148381acccacagat tttggtatct tctggggtcc tagaaccaat tcccagtgga tactaaagga
|
148441tggctgttat gtatataaca tactatcatt tatttaacaa atggggatac acacatattc
|
148501agacaaatat atgtgtgtgg tgtgtttgca tgtttttttt tatgggggta taagccaaaa
|
148561gctaaaaaaa attacctaga gagagagcaa aaataaaata atagtagcaa gaaaaagaga
|
148621aggacgaaga ggaaattgcc tatacgaaaa agaaacaggg taaaagtgaa gatacagtta
|
148681gactttctca taatatacca ttggaacaat gcaaatattt tacacaatta taaagtaaaa
|
148741ttaaattaaa ataaaaagca tacatccgtt tctgactaaa atggagtata aagaccagat
|
148801ttagctccca cctaaaacca aaagagagga agaaaaaaat caacaacagt tttgaagaca
|
148861atgaacatca ggcattgaag gacagtgatc cctgagacac tgaaaacaag caagataagc
|
148921cctgtgattg ccccagctta cagccttaag agagtctcca gactggaaca caaggaggag
|
148981gaatacaggt ggagacctgc agattcccca cgtttgagtt gaagagaaaa tgccaagagt
|
149041ctgaggagac cacagtgact agaacccaag gaactgaagg gtaaacaaaa gagagctgca
|
149101cagagaatgt ggagatccag agggtccctt tcaagtattc agcttagcgt tgatccattt
|
149161atgcctgtga ggaaactaga taggactggg aaaagaacta cccaaaaaga ttagaggtaa
|
149221cagcgctcgg tgtgcacaag ggggcggaaa tagtctgttt ccaccagcca atatggaaaa
|
149281ctgtatgatt cccggggtac tgggtagagt acagtagaaa gatcttgcct cactaatagg
|
149341gaatacttag ccctagacta agtactgctc tggctccacc taacaaatct taaaagcaag
|
149401acaagaaaac atcaaactgt tttcaaataa cttaaatatg tcccaaaaca atgttcaaga
|
149461acatttatag gaataaaata tatctacagc attcagcaag gtaaaattca caatgtgagg
|
149521cacccaaccc aaaattacaa ggcatgtaaa gaagctggaa aatatgactt atMataagga
|
149581gaaaaatcaa tcaattgaaa ccaacccaga actgaaactg atattagaat tagtagcaag
|
149641aacattaaaa cattatttgt atgctctgtg ttcaagttta gtaaaaattt gggagataca
|
149701tatgtatttt taagactcaa atttaacttc tagaaatgaa aactataatg tgcaagatga
|
149761aaatcatatc agagggagtt aatgtcagat tagatattgc agaagaaaag acagataaac
|
149821ttgaaaacac agcaatagaa actattccaa aatgaaaccc acaggaaaaa acagaaaaga
|
149881aaaaaaaata atggcataaa tgagctgtgg ggcaacttca aacagcctaa tatatgtgta
|
149941attgaagaaa gggaagaaaa aatatttgta gaaataatgg ctggaggctg ggtgcagcgg
|
150001ctcatgcctt taatcccaac actttgggag gccaaggtgg aagaatgcca taagcctggg
|
150061agtttgagag cagcctgggc aacatagtaa gatcctgtct ccacaaaaga gagagagaga
|
150121gagagagatg aaagagagac agagagagac agagaaaggg aggaagggag agagggaaga
|
150181aagggaagga aggaaggaag aaagaaagaa tttaaaaaga aataagggct ggaaatttct
|
150241gaaatttgat gaaaactata aacccatagg tctaagcagc tcaataaagc taggtacaat
|
150301aaacattaag aaaactacag caaagtatgt cataatcaaa actgctcaaa aatagtgata
|
150361aagagaaaat attaaaagca accagagaaa ggaaacatgt taacatatac aggaacattc
|
150421ttatctttgc aatgcaagca agaaaagagt ggttcaacat ccctacaata ctgaaaggga
|
150481aaaaaaaact tgtcaaacta gaattctata cccagctaaa atatctttca agaactaagg
|
150541caaactaaag atagtttcag atatacaaaa gctgaaataa ttcatcatca acaaacccac
|
150601actctaagaa atgttaaaaa gaagtacttt aggcagaagg aaagtaatac cagacctaaa
|
150661tttggatcta cacaaaggaa tgaacagcat cagaaatggt ctagtacatg aataattata
|
150721cgagatgttt ttcttattat tttaaactca ttaaaagatg atcaactatt tttaaaaata
|
150781caatgatggc cgggcgcRgt ggctcatacc tgtaatccca acaatttggg aggccaaggc
|
150841aggcacatca cctgaggtcg ggagttcgag aaccgcctga ccgacatgga gaaaccccat
|
150901ctcgactaaa aatacaaaaa ttagccaggc atggtggcgc atgcctgtaa tccatcaaca
|
150961catctactct gactctgaac tcctcctgcc ttccttttat aagaaccctt gtgattacat
|
151021taggcccacc tggataatcc aagattatcg caccatctca aaatccttaa tcctgtcttc
|
151081gaagtccctt ttgccatgta aggtaacata cgcacagatt tcagtaatta aaatgtggat
|
151141gtctgaggtg aggaggggcc ttattctatt aatcacagta ctattgtaga ctccttatac
|
151201tattcatgaa atagaataat ataatttgaa agttaactat aattaaagat gtacactata
|
151261aacactaagc aatcactaaa ataacaacaa aacaagagtt atagttaata aaccaacaaa
|
151321aaagagagaa aacataatca cattaaatgt aaattgccta aataccccta cttaaaaaag
|
151381attgtcagat tacatgtaaa aagcataaca caactatatg ctgcctatta aaaaactact
|
151441tttaatataa agatgcaaat aggcaagaag taaaagaatg gaaaaagata tttcatgtta
|
151501atattaatca aaagagagct ggagtggcta tattggaatt agacaaagga gatttcagat
|
151561aaaataatat taatagagat taagaggatt attttataat gataaaggaa tcaatttatt
|
151621gaggatataa caatactaaa tgtttataca cctaataaca aagcttcaat atacatgaaa
|
151681caaaaagtaa tagaattgta aggagaaata agcaaaccca caattatagt cataagtttc
|
151741aataccctac ctctcaatga ttcatagaat aaatagaaaa taaggatgta gaagatttaa
|
151801aaaacattat caaccaattt gacctaattg atatttatag aacattccaa acaacaacag
|
151861caaaacacaa ttcttttcct gagcaaacag aatatttacc aaggtagacc acatttggtg
|
151921ccataaaaca agttgcaata aatttaaaag aatttgaacc ataaaaatta ttctctgacc
|
151981atttggaatt aacatggaaa taaataatgg gcacaacttt ggaaacgtcc caagtgtttg
|
152041gaaactaaac aatacagttc taaataatcc atgagtaaaa gaagaaacca aacagaaaaa
|
152101tattttgaac tgaatgaaac taaaaaccct atatcaaatt ttttaaatga ggcttacata
|
152161gtatttatgg ggaaattata tcagaaaatg atgtagtaga aaagaaatat cttaaatcaa
|
152221tgacctgttt acaccttaag aaatagataa acctactatg taccataaaa attaaaaaat
|
152281taaaagaaat aagaaacaga agagcaaatt aaatccaaag taaatagaag gaaatataaa
|
152341gatcagagca gaaaaaacaa ttctaccaaa agctatttat ttgaaaagat caataaaatt
|
152401gataaacctc tagtcagaat gatgaggtaa aaaataacat tcaaattaac aatataatga
|
152461gtaaaataat atgccaccac agattctaca tatattaaaa gagtaatgca gcaatattat
|
152521gaacaacttt gtgcaaccaa ttaggagaat gtagataaaa gaaacaaaat cacatactaa
|
152581caaagcttac tcaagatgaa atagataacc taaatagccc tatatctata aaataaatta
|
152641aatttataat taaaaacatt acctcaagga aactgccaga tccaaatgga ttcactggta
|
152701aatgttataa aatatttatg gaagaaataa taccaattct atataaagtt tcagaaaagt
|
152761aaaaatgaag aaatacttcc caactcatta tatgagacca gcatcaccct gacacccaaa
|
152821ccagacagac attacaagaa aactatagac taatatctct cataaacata gatgcaaaaa
|
152881ctctaataaa acttgagcaa catgaatcta acaatacatt aaaaagataa aatagcataa
|
152941caaagtgggg tttatcctag gaatgtaatg ttggtttaac attcagaaat caatcaatgt
|
153001aactcattat gttaaatgta aacttaagat attaaattta atcaaccatt cctacataat
|
153061gaagcttcca tgaacaaaag aaaaaccaca tgatcatctc aatagacaca gaaaatcaga
|
153121tgacaaaatc aaatatccat ttgtgattta aaaaaaaaaa ctctcaaact agaaatagaa
|
153181gggagcatcc tcaatctgat aaagaatatc tacaaaaaat tctacagcta atgtcatact
|
153241taataacaaa aaaataaata aatgctttct ctttaagatc aggaacaaca taagggtgtc
|
153301cagtctcacc acttttacct aatattatgt tggagagtct agccagtgca agagacaaat
|
153361aaaataaata aaagttattc atattaaaag aaagaagtaa gttttcttta tttactattc
|
153421aggttatcta ctagcaaact aacagataat caactatata gaaaatgcta cagaatctat
|
153481agaaagctat tagaactaat gagtttagca aggttgcagg atataggaag aatatactaa
|
153541attaattgtt tttctatata ttagcaaaca tcagaaatta aaatgtataa aaatttattt
|
153601ataatagtat caaaaagtat taagtgctta gagacaaatc tgacaaaaat gttaaagatc
|
153661tatacactaa aaattaaaaa tcattgatga gaaaaattaa agaagatatt aataaattga
|
153721aagatatgcc atattcatgg gttgcaagac tcaatactga aaattgtcaa ttttccccaa
|
153781atggatctat agatgcaaga caatcccaac caaactccta gccagttttt tgtagaaatt
|
153841gacagactga ttataaaatc catatagaag tgcaaaagac ctagaataat caaaataact
|
153901aagaaaatca agaacaaatt tagagggcta acaccacctg atttcaaaca ttataaaact
|
153961ataataatca agacagtgtg gtaagagtat aaagatagac aaataggtca ataaaacaga
|
154021actgagagtc cagaaataaa cacacatata tgtggacatc taatttttga caagccaatt
|
154081aagtggagaa agacgagtct tttcagcaaa ctatgttgaa acaattgaat atccatctgc
|
154141aagaaaataa actaatgcat actttgtaYc atatacaaaa ttaactcaaa atgaatcata
|
154201gacctaaatg tgaaacctaa aattataaaa ttttaggaaa aaaaaataag agaaaccctg
|
154261accttgcatt aggtagtaat ttctcagaca taacatcaaa agcacaattc atgaaagaat
|
154321aaattgataa actggatttc accaaaattg aaaacttctg ctctttgaat gagactgcta
|
154381agttaatgaa aatacaaacc acagattgta aaaaaaaatt tgcaaagcat aggtctgata
|
154441aacttattgt atctagaata tataaagaac aatcaaaatt caataataag caaatagctc
|
154501aattttaaaa tggacaaaag atttgaactt taccaaagaa catatatgga tggtgtaata
|
154561ttgtgatata atgagaaatg tatattttgg tcttaatccc cacttcctgg cacacagttc
|
154621ctaaaacccc tggcatctcc aagtgatgtg tctttttata tgctaatgag atgaccctgg
|
154681ctgggacctg ctggatagcc tctggataag ggattataaa cagcggagcc aaccacaaga
|
154741ttagcaggct gtacctttta gccccaactc taacttccca cctctgacct ccaggaagaa
|
154801aagaggcact agtagttgag ctagtcacta atggccaatg atttaatcaa ccattcctac
|
154861ataatgaagc ttccatgaaa atccaaatgg actagattca gagatctttg ggttgatgaa
|
154921catgtggggg tgctgggagg gtggctcacc tggagaaggc atggaagctt catgtctctt
|
154981ttccccttac cttgccccgt gtacctcttc catttggctg tttcagatac atgtccttcg
|
155041taataaactg gcattYtagt atgcaaacta ttttcctgag ttgttttttt tttttttttt
|
155101tttttttttt tttgaggcgg aatgtcgccc aggctggagt gcagtggcac gaactcggct
|
155161cactgcaagc tccgcctccc gggttcacgc cattctcctg cctcagcctc ctgagtagct
|
155221gggactacag gcgcccacca cgcccagctt attttttttg ttgtattttt tagtagagat
|
155281ggggtttcac cgtgttagcc aggatggtct cgatcttctg acctcatgat ccacccgcct
|
155341cagcctccca aagtgctggg attacaggcg tgagccaccg cgcccggcct gttttcctga
|
155401gttccagcaa atgatcaaac atgaggggca gtcatggaaa cctccattta tagcccatag
|
155461gtcagaagca cagctgacaa cctggacttg aaaYtggcat atgaagttga ggcagtgctg
|
155521tgggctgagc ccttagtctg tggaatctga cgatatctca cagtagatag tgtcaaagtt
|
155581gagttaaact gtggaacacc cagttggtgt ccgcagggaa ttggagaatt gcttggtgta
|
155641ggggaaaaga catccacaca tctgctcaca gaaatattga gtaaaagtat agagaataaa
|
155701acagtttatt ttccctcaca gatggcaaat aagcacatgt gaagatgctc aaaatcatta
|
155761ttaactaggg gaatgcaagt tgaaactgca atgaaatact actatatatc tattagaatg
|
155821gctaaaaaaa ttttcaaact gaccacacca agtgttggca aggatacaaa ggaagtggaa
|
155881ctctcatata ttgctggagt caatgtaaaa tggtacaacc actttggaaa agagcttggc
|
155941agtttcttta atagtgaaac atctatctct cttatgatct agttgttcta ctcctaggta
|
156001gttaacctct caaggagaaa ggaaagcata tgtccattca aaaacttgta cacaaatgtt
|
156061catagtggct tgatttatag tagtcaaaga ctgcaaacaa atccaaatgt ccatcaacag
|
156121gtgaatggat aaattaactg tgatacagcc atgcaatgga ctactactca gcataaaaag
|
156181gaattattga tatagtatta attagtaatt atgctaagtg aaagaagcca gacatgccct
|
156241tgtccctaaa aaagggagta cacaggccgg gtgcggtggc tcacgcctgt aatcccagaa
|
156301ctttgggagg ccgaggcggg tggatcacga ggtcaggaga tcgagaccat cctggctaac
|
156361acggtgaaac cccatctcta ctaaaaatac aaaaataatt agccggggag gctgaggcag
|
156421gagaatggcg tgaacccagg aggcggagct tgcagtgagc agagattgcg ccactgcact
|
156481ccagcctggg caacaaggcg agactccatc tcaaaaaaaa acaaaaggga gtatacagtg
|
156541tgtgtttctg gtatagaaag caaatcaatg gcttctctgg ggagggagta aagaagggta
|
156601gaggcatgga gaagcgcagg aaggatagat ttctaaacac ataggaaacc tttgcgagtc
|
156661atggatatgt tcattatctt gattgtggta atggttccac aggtgaatat atgtcaaaac
|
156721ttatcaagct ggacacatta agtatgtgca atttattgta tgtaattata cttcaataaa
|
156781gctgttaaac ttttttaata acaaggcaat ctcagggact tctgcttctg gaaagatgaa
|
156841atagatacac ttttttatat tcctctcact aagcacaact aaatatcctg gacattattc
|
156901atagaacaga cataagaaat aactgaaaga tgaagggaac cagtcagacc agctagggac
|
156961tttgggacct gagaaacaac agggtgggtg gtgagctccc tgggtattat tttatctatc
|
157021tacctatcta tctagctatc taactatcta gctagctagc tatttattga gacaaagtat
|
157081cactctgtag cctgggctgg agtgcaatgg cgcaatcctg gctcactgca gcctcaaact
|
157141cctgtgcttg agcaatcctc ccacctcagc ctcccaagta gctgggacta caggcacgca
|
157201ccaacacacc tggataattt tttaaatttt tatagagaca aggtctcact atgttgctta
|
157261ggctagtttc gaactcctgg gctcaagcaa tcctcctcct ttggcctccc aaagtgctgg
|
157321gattacaggc atgagcctgt gtccagcccg atcttgggtc tcctttatgc ctcatatatc
|
157381ctggactgga ttctggaaaa gctgataacc cagaaacacc aacaaatgaa gaccaaaaaa
|
157441gacctcaaga aaatcctgct ctctctagcc agagaaccag gaaaggacca gcctagcaag
|
157501acaagcaggc atcccaatag ctttgctggg ttggtgtcag agaaggccaa gggaagagct
|
157561ggtgccttgt ggtatcagta gaggccctcc tcctcccaag taggataata ccagtagagg
|
157621cctagtgggg agcctgaact cccacctcca ctcagcaaca acaaggtgtt cttcccctgt
|
157681taaagaggat gtcaacagaa gccaagtaga gaagatggat ttccacatcc atctgacagt
|
157741aataagggga gcctcRcctc ccctactagc atagcttgaa aggagacctg ctaatataga
|
157801agatttaaat aatatctagc gtctcataaY ataacagcca aaatgtccaa gattcagtca
|
157861aagccactca tcttatgaag aaccaggaaa atctcaaatg aggaaagaca cagacaccaa
|
157921caagaaaata acaaaaatgt tagaattatc tgacaaggat cttaaagcag ccatcattaa
|
157981aagtgtttca acgagcaatt atgaacacat aaaacacatt cagcaaagaa atagaaaata
|
158041tgaagaacca aatagaaatt tgaaaactga aaaaaattgt aacaaaaaat aaaaaagctc
|
158101tcaatggatt ggcttaacag cagaaggcag aggacagaat aaagaagcaa tgaacttgaa
|
158161gagagaacta tagaaatcac ccaagctgag caacagagag aagaatttta aaaataaatg
|
158221aacacagcct cagggactta tgggactata acaaaagatc taacatttgt gttgttgaag
|
158281tccgagaagg agaggggaaa gagggttgaa ctgaagaagt attcaaagaa ataatggctg
|
158341aaaaattccc aaatttggca aaaaaaaaaa aaaaaaaaMc ccataaaccc acaggttgaa
|
158401gaagctgagt aaactcaaac agaataaacc caaaaaatct atggcaaaac acatcaaaat
|
158461cacgtttctg aaactaaaaa caaagaaaaa acttgaaaac aatgagagag aaatgacacc
|
158521ttacttataa gggaaaaaag catttaaatg acagcagatt tctcatcact aaccatcaga
|
158581aagaagtggc aaaacctttt tcaactgcta aaataaaagg actatcaact cagaatttta
|
158641tatccagcaa aaatatcctc caggaatgat ggcaaaatca agacattctc cactgaagga
|
158701aaactaagaa gttgttacca tcagatttac tctaaaagaa tggctaaaga aagtactaca
|
158761tcagaaagta aatgctaaaa gaaggaatct tggaacttca gtaagtaaga aaaacaacga
|
158821aggagtaaaa atatgagtaa atacaataaa cgcttctctt acgttttcta aattatgttt
|
158881gatggttgaa gtaaaaatta taacactggt atggttttca atgtatgtaa aggaaatgct
|
158941taagacaact atattataaa gggaggaggg taaaaggatt taaataatga gtgttgggtg
|
159001gtaatagaat agttttgtat cttgattgta gaagtggtta cacaaatcta gacatgtgat
|
159061aaaatggcat aaagctacat atacacattt taccaatgtc agttttttgg ttttgatatt
|
159121gtaagatgta ttaatcttgg aggaaattgg atgaagaaga taggggatct ctattatatt
|
159181tgcaactgca aattgcaaat acagtcacaa ttgcaattat taattatttc aagataaaag
|
159241ttgatttaat aaagaagaaa ttatatgaat cccctcccca ctcaaaaagc aaaccctgat
|
159301aagtgaaagc aaaatgaaac aaataaatcc aactgtgtat tgagttagtg gcacaatcac
|
159361acagaggaac tatctcagtg accttaaagg agagtaattt ggctgcacat gtttaatgga
|
159421atatacccta aggacaaaaa gacttgcaaa aaaaagaaaa tatcttaaac ctttttcagt
|
159481aatcttattg ttaatagtca tattgtttgt tctgatactg tgtgtgagtg tctgtgtgtg
|
159541tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg taaaataaag caaataagta attacatcaa
|
159601tatcatttct aggatttttt ggtgtaggag aaaggagata cagaattaag atacttaagt
|
159661aaaaactgtt taaatctaaa ttgaatggga tgtatcaaca taatttcata atgtattttc
|
159721tcttaaaaag aaaaagaaaa aaacaaatga atactatttc ttagttctag tcactgataa
|
159781ggcctagaaa caatgaccaa gccaggagca atgaacagca ctgcggtctc taagtaactt
|
159841ttcctacaaa caggagccag gatttcttca agaaatagct gatttCagtc ctggagagga
|
159901ggaagYgtac aggatgagct tgaaatattt catcctaata ttaggatggc Wagaaggcca
|
159961tcagaaacta ctggggttgt ttcaaaacac cagcactggg ccgggcacgg tggcttacgc
|
160021ctgtaatccc agaactttgg gaggccgagg caggcggatc atgaggtcaa gagatcaaga
|
160081caatcctggc caacatggtg aaaccccatc tctgctaaaa atacaaaaat tagcYgggtg
|
160141tggtggcatg tgcctgtagt cccagctact cgggaggctg aggcaggaga atcgcttgaa
|
160201cccgggagRc agaggttgca gtgagccgag atcatgccac tgcactccag cctggctact
|
160261gagtgagact ccatctcaaa aaaaaaaaaa aaaaaaaaca catcagcact ggccagaatc
|
160321ctgaatggcc agagatgagg caagataagc Ytcataagaa taatagctac actggattaa
|
160381aatacatcaa atatgtttaa atctgtgagt tcctggtggt attcaaaaaa ataattatta
|
160441ttatattgat cgtctttgga gaatgctagg gaaccaactc attattttga aaactggtaa
|
160501atagagggga aaaaagtcat ttatcctgcc tttcatatgt gaactgtatc tcacaataac
|
160561taaaatttta atgagggaat gtttttcttt atagaagttg tagagctaac aaatgaagat
|
160621ataatgatag tcctggattg aatattaact ttttgcaacc cttaatggga taaagaatct
|
160681aggcaattat catgaagggc tgctaacatc agtaaaagag gtaaccagac tgtatgagcc
|
160741tcttgatgaa agtacacact accactcagg agttgttctt accaaaaaaa aatggaacct
|
160801gaataaatct ctagacctaa ctaccaattc acagKaataa caccatggga acgcaaccaa
|
160861atccttctgg gaaaccctac agcgtaagca acccagtgtc ttcaacaagt aacatgcaag
|
160921gaggaaagag agagaggcag agacagagag aaacccagag atgttaaaag acacattaac
|
160981cagttgcaat gtagggttcc catttggatc ctgatttaaa ctacaggggg aaaaatgaat
|
161041gttggccaaa tatttgatga tattaaagtc ttattgctaa ttatttgagc tctgatagtg
|
161101attgtgagtK tgtttgtttg tttaagttct ttaccattta gagatacata acaaaatatt
|
161161tacagatgaa atcacgtgct tttgtggatt tgcttcaaaa taaaatgagg tcagggagaa
|
161221aagtaaggag tgcgtataga tgaaacacga ttgaccatga gttgaacatt gttgaagcag
|
161281ggctacatgg ggatgtgttt tactattgtc ttcagtttta tatgaaggtg aaatttttcc
|
161341aaatgWaaca tttttaaaaa catatccagg cagagccaga aaaatcacat tcctgtagct
|
161401gtctccctaa taaaaaggtc tttattctgt tctttgcagc ctagaagact agtgtcactg
|
161461tagctgtagt aataacagta atatcaataa taataggcca ggtgcagtgg ctcacgcctg
|
161521taatcccagc actatgggag gcccaggcag gcagatcatg agatcaggag ttcgagacag
|
161581cctgaccaac atggtgaaac cccgtctcta ctaaaaatac aaaaactagc tgggtgtggt
|
161641ggcgcacgcc tgtaatccca gcgactcagR aggctgaagc atgagaatca cttgaacccg
|
161701ggaggcggtg agtcgagatc gcaccactgc actccagcct gggcaacaca gcaagagtcc
|
161761atctcaaaaa aaaaaaaata acaataataa taataatacc cagcattttg gaagcacata
|
161821cttgctatgt gctaaactca tttaagagtt tttataaatt ttctcattta attcagacga
|
161881aatcttatgt ggtaagtact attattattc acattttaca gatgaggaac ctgagggaca
|
161941gaagtttggt gacaaaggta agcctcacac ccagatctaa tggcagattt ccggcttgta
|
162001accaacaccc aaaggtaaaa gatgaagatt gctgtcatgt cctcagtctt gccttctttg
|
162061ggataaacac ctttagctct ttcactcccc accccacccc acccctgcca catggcttca
|
162121atgccccaca ccatccttgt cacattcctt gaaacacctg ccaggagcca taaaagtagc
|
162181tgagcttctt taaggtatct cagaggccca tgtgcagctt gccccacccc gatcctaccc
|
162241aggctgcctg gtttcccaga caagctgcgg tcctcctccc tccaggctgg gagcctgcac
|
162301atgcgcatgt cccaggagtg gcgcagctca cctgggcctc ggtgcctctt ctccatccag
|
162361atgtagcagt tgttctgggc caccccagtc tgtgagtcca ggaagggaag acgcacgctg
|
162421cgctctgcac acagccgtga gttgtaactc cggcagtgct caatggcttc cttgtagaac
|
162481tggtccccga gcctgccaga gtcagagagt gaaggggtga ggccagggaa gactgaaaca
|
162541cacccagagg gaaacacacc cagagggaaa cacacctccc tggaaagact gaagacctcc
|
162601cagttatgaa gaccaaggca atgagcacca agagccttgc caatgagcag aatgcaactc
|
162661aatgtcaggt cttgactaga ttttattttc tatcccaaat ccaccaggca acttagaaac
|
162721tcctttaaca aagagcatgg gcttccaagg atgaatcacc agtaagagag agctgtccat
|
162781gttctaggaa gcatgaggtc ccactccaga agggaagtag ctctggaaca accttctgca
|
162841tggaatctag aggacatcac acttctagaa cctcctcact catattagct acattttatt
|
162901ctcagaggtc accagcaaag gcactctagg tgaacccaaa tcaccagcaa agatactcag
|
162961ttttccatta caacagaaga gaaacactcc atataaacaa aaactaggac agaaaaaaca
|
163021ttctataaaa gtagggaaat tgcaggaaga agggggtgta gaggaacagg caccaatctt
|
163081ttaaaaccat attacttaaa gaaaaataac tttccgatag aaaacaaaca gaattcaaca
|
163141attttaaatt caaaataatt caactcatgg agtttaaaaa acaaatagaa agacctttct
|
163201ggtttgctag actgagaatc tgattaagca cagtatattt tacgttcctg actctttggt
|
163261atttttggac acgtggtgat gctactaatt ttaaggtagt gtccttttca aagaccaaaa
|
163321atggagcatt gatataattg atcaaatgca aagcactaaa ataatcaatg agatcaaata
|
163381cctaccaaat aaaacatagg cacaggttaa taaatgcctc aaagaaatac aaatgtaata
|
163441acataaStta tgccaggtaa attcaagcct cttactggRg tcggggggca gtggacgcaa
|
163501aggagtggag tgtgggaaga agaagtagga agggaaggag ccacagagtt cacaggggca
|
163561aaagggagaa tcaagtgttt attctgaagc aacattatga tatctttttg ttttggttct
|
163621atgtagattt cagaaagcca aaatgagagg ggaagtctct aaaaatatca tttcttaacc
|
163681aaagtattta gaggaataaa aaaagcaaaa ttggggtgtt gggttttttg ggtttttttt
|
163741tttttttttg agatggagtc tcactccgtc gcccaggctg gagtgcaacg gtgcgatctc
|
163801agctcactgc aacctccacc tcctgggttc aaacgattct cctgcctcag cctcctgagt
|
163861agctgggatt ataggtacct gccaccatgc ccggctaatt ttttatattt ttagtagaga
|
163921cagagtttca ctatattggt caggctggtc tcaaactcct gacctcaggc gatccacccg
|
163981cctcagcctc ccaaagtgct gggattacag gcgtgagcca ccatgcctgg cctcaatttc
|
164041ttaattgtgg taaaatacac ataacataaa atttcccatc ttaagtgtac agtttaagtg
|
164101tacagttcag tggcattaag cacatgcata ctgttgtacg accaccacta ctatccattc
|
164161ccagaactct tttcatcttg caaaactgaa acactatacc cattaaacaa taactccccg
|
164221ttccgcctct gcccccatct ccagcaacta ccaatctgct ttctatctct atgattctga
|
164281ctactccaag tacttcataa aagtggagtc atacagtatt tgtctttttg tgactggctt
|
164341atttgactta gcataatatc ctcagggtta acctatRtta tagcatatgt cagaatttcc
|
164401ttccttttta agtcagaata atattttaag tcagaataat attttttaag tcagaataat
|
164461attccattgt atgcatatac cacattttgc ttatccattc atctgtcagt ggatatctgg
|
164521gttgcttcca cattttagct attctgaata atgctgctat gaacatgagt atacaaatat
|
164581cttttcaaaa ccctgctttc aggctgggcg cagtggctca tgcctgtaat cccagcactt
|
164641tgggaggctg aggtgggtgg atcgcctgag gtcaggagtt cgagaccagc ctggccaaca
|
164701tggtgacacc ccgtctctac taaaaataca aaaattagct gggcctggtg gcagacgcct
|
164761gtaatcccag ctactcaaga gtcgcttgaa ctcagaaggt tgtggtgagt tgggattgtg
|
164821ccactgcact ccagcctggg cgacagggtg agactctgtc taaaaaaaaa aaaaaaaaaa
|
164881aaaaaaaacc tgctttcagt tcttttaggt atatactcag gagtagaatt gctgagtcat
|
164941atggtagctc tagttttcat tttttgagga accaccatac tgtttttcat ggcagctgta
|
165001ccattttcca tttctaccaa cagtgtacaa gggttccaac tactccacat tctcatcacc
|
165061acttgttaga aagcaaagtt ttaaatgcac ttttctatac tctttttaaa aagtcaacgg
|
165121gtcaggttct aacaaagagc ttaaagcaaa tatcttactg tgggaaaaca caaccctgga
|
165181agcttctgag gcatcatttg gaaattactt gttgacaagc atccaaaaaa aaacaaacaa
|
165241caaaacaaaa accctttgct cctttttcac ctctgaacat cttcacattc ataagggagg
|
165301cataatacgc tcagaaagtg tcctggcagt tgcaaaacca aactgtaatc aaattgtaat
|
165361agtcacgcag ctggaaatga attggggagg ggagatgaaa gcccattaca atgctataaa
|
165421actgaatggc acataagctg atgtaatcaa agctggtaac aaggatcatg agattgatca
|
165481aaaataaaga accacttttt acaaagtgtt tgtgtcacac cagcttaaat gcttccttct
|
165541gctatggcga tgtagctcag tggaacagaa ctttcacagg cagcttggcc cagacaagat
|
165601gacccaggct gttcagggta tcctggatgc tccagccccc acccatgaaa cagcaagcag
|
165661ccataccaca tcgatagaga actgacaaga acatttgaca gagaggtgtc caacgtgaga
|
165721gcagcaatct gttttcccag gaccttctga cagactgcca aaaaaaaaag atgttaatta
|
165781tcccaacctc agaaattctg ctgaaaagag aacccataaa atcaggcccc ccaaaaaaac
|
165841aaaatgaaaa attgtatagc aaaactcatc tactggagat gatcactttc aaaataaatt
|
165901tctggaaacc aatacaaaag aaatctacac agtaggattc caaattggac ttgtcctaat
|
165961atgctagtaa ctcacttcca acagcgtcaa tccagacaag aggaacaaga aactgaactt
|
166021gctaaaaatg caaagtgagg ttggccaaca ctggtgctcc acaccaactg gatcgagaat
|
166081gtcaaacaaa gtggcacact gggcgaaaat taatttcatc ttaaatactt tctactttca
|
166141taacatgcaa tgttattagt tacaagcatg ctgggggaaa atgtatattt ctaaatataa
|
166201tctttgtgtg aatgatacct gtcttatgta aacagaaaag actttctgtg gactggaaca
|
166261actgtattaa agatcgaagc tgcaaaaaca tgacattcaa cagcccctct accatcatct
|
166321ccagggaRgt ccttttaaac agaccaggtg ttggcagaga Ytcggaacca aaatttaaag
|
166381cctttttcaa gatataagag gagaaaagag atttcatcct ccctgataaa ttcaagaagc
|
166441acttctccaa aagttaatta gccaaaatcg tcacagggct tgctatgctc tctagaagaa
|
166501aatcaatgac tagttctccc taacccgtag aaagcaattt aaacagcaga ggacaaatgt
|
166561cctttccaac atggtatttc tgccaaaaaa aaaaaaaaaa atcccacaat gatgggatcc
|
166621caggagtgac atttacatta aagttgaagg cgtcagatgg agcagggaaa ggctggcagc
|
166681aaatgactca tctgtggagt ggtgaccagt gtaccctggg ttggatcaca catgggacag
|
166741tcccagccat cacctgcatg caccaaactg agggggctgg atccccaagg gatgattgat
|
166801gtcttaggct agaggaagct ggcacaaggc agggtagaat gatgttctta tcaacaactg
|
166861acttcaggct actcaaggct gcaatcagaa ataggaaagg caagggaaac aaattgctgg
|
166921gctccccagg ctccccagac agcattctgg ttgcagcagt gctggctgcc tagttctagg
|
166981gggctttgtg agtgatggag gtMcttctgt gatcccatct gaattgagaa gccagMccag
|
167041ctctgagagc tgagtgtttc tacatgagat ttccagcaac cctccttgag cctatctgtg
|
167101gagatggact ccagggggcc aaagaagact cagaatggga aagatgagac ttctccaaag
|
167161tgactgccaa ccaggctcca aatgtgattt ttcagagccc atcaatcaca acccctctaa
|
167221gaccctctgc tcctcttcct ccaacctcct gctctcaaga ccacacctgc ttgctccgat
|
167281ttctcagatc actctcaggt ccagccagac acctgggctc ctccctttca ctgtctctct
|
167341ggttctgtgc tctgacctga ggacaggtgt cctgccatac cagaaatgtg agtccaatag
|
167401caagtttctc atcttctgcc agaagcctgc tcccgcccac tcaagtctca atcctcctag
|
167461gggcgggggt gggggtgggg gccgaggcta tgctgccctc cctctcccta gcaacttggc
|
167521cttgactctc cccttgcctt caaaccatct ggaactgagt tatttcattt atcaggaagt
|
167581cgtcctttct ctccactccc cctgtgtggc cccaagtccc ctttgctgtg taaacaggac
|
167641cttggcccat cactactatc tgtgcacaga agcagagata agcagagctg aagagaagcc
|
167701ctggcctgtg gcaggattgt gggggctctc cttcccccag aggcgcctct tcctcactRt
|
167761gggcaccaag ttttcctgct gtctcactca gctgttcaca ccgccagagc cgcccacaaa
|
167821cacacacgRa agctcatcta caccaatatg ctaacttcct gctatttgca tttaaacatg
|
167881tttaactcaa actgttcatg gaaagctccg tctcccattt agtcttttag aataactggc
|
167941acacaggggg caatatctgg caaggtgcgg gaaagttttt attttccttg aagtggtcct
|
168001gttcctaatg catctcttga aagaagacca agtttagtgt ttgttacaga ctgaattgtg
|
168061tcgttcctcc tcacagaaaa aatccacatg ttgaaggcct aaccctcaat gtgatggtgt
|
168121ttggagatgg agcatttggg aggtgatatc atttgatatt tacccctgcc caaatctcat
|
168181gttgaattgt aatccccaac tctgggggtg gggcctagtg ggaggtgttt agatcatgtg
|
168241ggcacatccc tcatggcttg gtgctgtctt cgtgatagca agtgagttct tgcaagatct
|
168301ggtcatttaa aagtgtatgg tgcctccctg ctgactctct ctctcttgct cctgtttttR
|
168361tcatgtgaca tgcctcctcc ccctttgcct tctgccatga ttgtaagttt cctgagggct
|
168421ccccagaagc caagcagatg ccagcactgt gcttcctgta cagcctgcag aacgatgagc
|
168481caattaaacc tgttctttat aaattaccaa atctcaggta tttctttata gcaatacaag
|
168541aatggcctaa tccaggaggt aatcaggtca ggaggatgga gMcctcatga tgggattagg
|
168601gcccatataa ggcagagaca tgagcaagct ctctcactct ctcaatctct gccatgagag
|
168661gacacaaaaa ggcagctgta tgtgagctat aaggaggact cttacctgga atctgaccct
|
168721gctagcaccc tcatcttgaa cttcccagcc tccagaactg tgacagacaa ttatttaagc
|
168781caggggtccc aaacccctgg gccacagagc agtaccagtc catgcctgtt aggaactggg
|
168841tggcacagca ggaggtgagc tgtggggtac aagtgagcat tgctgcctga gctctgcctc
|
168901ctgtcagatc aatggcagca ctagagtctc atagaagcgc aaaccctact gtgaactgca
|
168961catatgaggg atctaggttg cccactcctt atgagaatct aatgcttgat gatctgtcac
|
169021tgtctcccat caaccccaga tgagactgtc tagttgcagg aaaacaagct cagagctccc
|
169081actgattcta cattatagtg agttgtaaaa ttatttcatt acatattaca atgtaataat
|
169141aacagaaata aggtgcacaa taaatgtaat gcacttgaat catcccaaaa ccatcccctc
|
169201cccgacccca gtcggtggaa aaatgatctt ccatgaaacc agtccctggt gccagaaagg
|
169261ttggggactt ccggtttaag ctacccagtc tatgccattt taatacagca gctggacatg
|
169321actgaggaag tgtttctgga tgtttcccaa aaaagggcta aggaggacag gtgagagaga
|
169381ttccaatccc ctttccttcc acattttttc ttcttctaac aaagacaaca ataataacac
|
169441tataatatca atttcaactc aWttcaatgt ttagtatttg tcttctctac tagactataa
|
169501actccatgag ggcagaggcc acatctgcag agccactgca cacagacact caggctgaac
|
169561aactccagca agtaccattc acatcagcgt caatatgaag gccaccccct ggagtggtgg
|
169621agcccagcac tcctgcatac ctgcctggcc ttcttgctga tttacccgca gtgttcagca
|
169681cagagcctgg cacataacag gtgcccagta agtctccatt gaaaagcatt tgacaactca
|
169741cattccactc acctagggca ggcatttaaa ttacagcagg aaggctaatg tggcatgctt
|
169801gtgcacagtc tgcagagtct gtgactggca atttaaactg gatggctgtc cacttgcagc
|
169861ttcagaaaaa cattgagaga atgtctgcat tcactctcct gtagtcctca tcacccagca
|
169921cctgggacat tgcagcactg ggtggcctaa ctgcaagcgc tatagcccta ctcttaccca
|
169981tcctgacaaa aggaattctc cctgaaactc agtgtttagt ctttcaaact cctcagtgta
|
170041gaacccaaga tggctcccaa tggtgcccag gttcctctgc tgggctgggg atgcacccgg
|
170101aaaaactatg tattggggta aagtggaaaa tcaagacttg gaattggtca tgtctgagtc
|
170161cagctccacc tcttaatagc tacacaaccc tcagcaagtt acttaccctc cctgggccta
|
170221aattctacta ctcacaatat gggtaatata atctctactt cagacctgag aaaatttaat
|
170281aagctagaac ctctggcaca cagacataaa agtctgMaat caatagccat tcctttctcc
|
170341ttccccaaag tgcagtactt gctgccactt tgtggcatga ccctctgcct gagcaggctg
|
170401atacccacca tgtgatgcaa cactcactat tgcggtgtcc ttgaggctgt cggggaccca
|
170461ctcaaacctc tgtcccagga cagaaggcct ctgggtcacc aaggctgagc ctcaggcatc
|
170521caggagagca gggcagctga tgcatggtga ccccagcaat ccacccaagg actgccctaa
|
170581gcacagagac cacatctggc ttgtttactg ctctctccca aagcctagta catgctgggt
|
170641catgcctgcc acattgggta aatgatgaRt gaatgagtga atgaatgaat cctcctctga
|
170701cccccctgca tatatgaaac agacagccct acccctgaat ctcaacaaaa cactttactt
|
170761atatccttcc tcccacctgg aatttttgta ttctgtcctt gtcctggctg atcttagcct
|
170821agtcaagagc tggctgaaaa cttgcttctt ccaggaaggt tcacaggtta tctctaccag
|
170881tagggtttgc tctctggctt ctctgagcta ccttatctgt cttactttat ttttgatggt
|
170941ctttgccacc ttccttatct ctgctcactt aattagattg gaagtatctt aaagacagga
|
171001actgagagct atgtgcttgc atgctaccca accatgcaca gtactgggaa tgtagaagca
|
171061tgtgatagat acattgcttg actgaactat catgtcatcc tcagcaaact aatgaaagct
|
171121tcacagttga gaggtgcttg gaacgttcta actttctcca tgggaacatg aggtgagcct
|
171181gaagttatct ggctacttct ccagagccca ggattaggca tctgaaaata gatatcctcc
|
171241aagttcaaat cctattgagt tttttcccat atccttaaaa aaaggtcact tcagYtcctg
|
171301agattttcat ttctccatgt gcaaattcat gctaccctgc aaggtgccac agaactgaca
|
171361ttctccttct ctgaacttta caagaagctc actgNttctc aatgctgctg acatcagacc
|
171421tatgccagga Raaccagctc cttctctgca tgggtagaaa tgcccttctt gtgcttagtg
|
171481agaatgccat caccacatgc tccaaaagaa tgctctcaaa ctcaggattg tgaaagaatc
|
171541gctaaggggt gggaagctgt gcaattctga ttctagaggc ttgggatgtg atccagacat
|
171601cagctcccca gtgatcctga gaaatWtgag actagctgat ctaaagatag ctccccaacc
|
171661tctaaaacaa gggcatgaat gagaggggac ttgtgttgct cctcagccac catgtttgaa
|
171721tggcagagct ggacRgccca gttagcagac tttgtttcat tcagctggtt ttgtttctgt
|
171781gggaaaactt ctttcaggca gctggcatgg attaccctgg cagcactaac ctgcagcaga
|
171841ctaatcccac aaaagtcctc atccctaaca aaattgccaa aagccctggt caaggcaaat
|
171901gtatgaagat ctgacatcct tagtcattct gtgggtggct ctgaccttca aaacatctca
|
171961ggaagggcac aYtggggaca aaggtatccc ttgggaaagt tatgtccgac aaacagcttg
|
172021aaccctaaaa catccatcat gacttcgatg tggctcagtc tgatgttcag gcccagtaga
|
172081cccaataaat cccttttcca gcatctaccc tggtgaagac ttttcaggga cttattatgc
|
172141aaagctgcct aagcaagaca gaatttatat tgaacctggc catgatttct gagccgccac
|
172201tgggtgttct gatgacatac acatctcgag gttgaagtca aggagctgcc aaggacaWga
|
172261gactggtggc aggataaaag cagtgtgatt ccttccagta aataatggtg gggtggcggg
|
172321ggaggtggga aggggacgct ccggggagga agaggaccgt agcttttctt gtacccaagg
|
172381tttgcctttc aaatggcatc cagacgtgac caaataaatc tctcctctgg aggctaaaga
|
172441atgtgtaSaa tgcaacaaaa gtgaggtggt ggagaagcct gctttatcta gggtgaatca
|
172501tacctagaaa gaaaacatgc atccgtcaca gaaatttcat tgattgagaa aatattttta
|
172561gtttcctggt ccacagactg agtccttcct gaaactctca ctatgagctg ggcactcgga
|
172621tgttgcctcc tgagtgtgat cgcctataga agcagactat tgattagaga aaattcttag
|
172681acaaacagat ccccagccct catctttgcc actggaatgc aaagggtgct gccctcccca
|
172741gtaaagggaa tatcggtctg gtatttaaca cggccacaaa gaacatgttg ttctatagtc
|
172801aattctctat acagcagccc aagtgatttt tttttttttt tttgaaacaa ggttttgctc
|
172861tgttgcccag gctggattgc agtggtgcag tggaggagtg tagcctccac ctcccagMtt
|
172921caagcaatcc tcccacctca gcctccagag tagctgggac tacagacaca cgccaccaca
|
172981cttggctaat ttttgtattt ttttatagag gcagggtttt gccatgttgc ccagcctggt
|
173041ctggaactcc ggggctcaag cagtcagccc gtctcagtct cccaaagacc tgggattaca
|
173101ggtgtgatcc actataacca gccccagtga tcttttaaaa acagaaatca gggctgggca
|
173161cggtggccca cgcctgtaat cccagcactt tgggaggctg aggtgggtgg gtcacgaggt
|
173221caggagttcg agatcagcct ggccaacaca gtgaaatccc gtctctacta aaaatacaaa
|
173281aattagccag gtgtaatggc ggacacctgc agtcccagct acatgggagg ctgaggcggg
|
173341agaatcactt gaacctggaa gacagaggtt gcagtgagcc gagattgcac cactgcactc
|
173401cagcctgggc gacaRagcga gactccatct caaagaaaaa aaaaaagtgg aaatcaggcc
|
173461atggcaKtct ctcctactaa cacctccaat gtcttctcac tgcactcaga gcaaaatcca
|
173521aactccttcc catggctaca ggtccccagg ctggctgggc tcacctttcc tgcttcatcc
|
173581tgtcccctgc ctccttcccc gctgggctcc atcctcactg cactcctttc tgttcctctt
|
173641ctatactaag ggtatctcac ctcaggacct ttgcatatgc catctcctct acctggYatg
|
173701acatgcttct cccagatctt cttgtagctg actgctcctc tgagatgtct tcttaggttc
|
173761accctatctg gaagtagccc accccacccc aaccctgccc taccctttgc tatctcatat
|
173821actttatttt tttcataaca ccactatcaa agtttttctc tttgcctact gatcatctat
|
173881acacaactaa attgcaagtg ccacgagagc agcgtccttg tctcatcaga ttcccagccc
|
173941ccaacgcaag acttggcaca taggaaatgc tcgacacata tcactcaaca Raaaaatgaa
|
174001agctctaggc ccacctgcaa ctgacagctt gaatgatacc gaatcctggc cttgtagaag
|
174061gctggaagtc agtgctggca ggagaccccc Wgcacaggga ataagaatca cacagctgcc
|
174121accacctgat tcctggccct ttctgcccaa cacaacataa atgacagcag gtcagtggca
|
174181cagtccacag tccacactca aatcttgatc atggccaccc acatacccca aacctggaga
|
174241gagactgggg tgaggtagat aaacgatgcc attcaagaca tcagacattg ctttciatgc
|
174301ccaaaaggca cattccaggc ctgatattgg caccggaaac tagcagtgcc agaagatggt
|
174361ctccaacata cccatcccat gtccctcaaa gggcctctct ctggactaac ctcttctgca
|
174421tggtctttcc tgcagagctg atccgtgtcc tcctgcagag ccctgggccc acgggtggtg
|
174481ccaggggcag cggcaggatg ggggtggggc tgcttgacag gaaatcaatg ggaactgaag
|
174541gtcatccgga gggcgcagtc tccccatcac Kcacctgctg gcatgggatt tgtggtcctg
|
174601acctcgcttg ggggcctctg ccctcctgtc agagttggtt aaaatcagcc tgcagaagca
|
174661aatgtcctgc acaccaaatg atctccaggc agcccttcta agggacatcc agccaaacaa
|
174721agaagcactg agtctcattt cacccgccgc aaagttgaga gtcaccccaa tctctcttgg
|
174781cagcctccta ggaaaactgt ctcagacctg ccatttttgg aggcacatac ttgtaaatag
|
174841aacaaagcca gactgaccaa gaggctggtt atgtccccaa acttaagttg cctggtggtg
|
174901gaggaagtaa aaatacactg ggaaccaaga tgactgaaac tgaaatcttg agtgcaccct
|
174961agaaatgcct aaatctgccc tcaacacctc tacatgccag gataacgaca aaggatacca
|
175021aaacctctgt actgccggag ggaaatctca ttttcttctc atcccaaaaa atactgggga
|
175081gcttggctga atctagaatc tgattttcct tcccccacta tacttatttt cccaggttcc
|
175141cattctccct tgcttcccag acctttcccc tctaccatct tctttcccaa ttcgtccacc
|
175201tcatcaagag tcatttatca tacaggccag gagcaaagcg gtcagcctaa gtctccaatt
|
175261caaaagttga aaatgggcca ggcacagggg ctcacgcctg taatcctaac actttgggag
|
175321gccaaggtgg gaagactgct tgagaccagg agttcaagca ccctggccaa cttggtgaaa
|
175381aaccgtctct actaaaacta caaaaattag ccaggcttgg tagcaggtgc ctgtagttcc
|
175441agctacttag gaggctgagg caggagaatg gcttgaaccc agaaggcgga ggttgcagtg
|
175501agctgagatc gcaccattac actccagcct gggcaacaag agcaaaacac cgcctcaaaa
|
175561aaaaaaaagt tgaaaatgaa tatggtatga aaataaagaa aaggccaggc acagcagctc
|
175621atgcctggaa tcccagcact ttgggaggcc aaggcaggag aatcacttga ggccaggagt
|
175681tgaataccag cctgggcaac atagtgagat ccccgtctct acaaaaaaat aaaaaataaa
|
175741aaaatgtttt aatgaagaag agacaccctg gacatattta cagaaggata acaggatgct
|
175801ggttatagta gcaatagtgg catagctaat atttattgag catttactat gtgtgccagg
|
175861cactgttcta agcactttac atgtattatc cccatacaac ttgtaattgt attattccca
|
175921tacaactcca tgattttata cccaccccct cacacacccc actttacaga ttggcaaact
|
175981gaggcacaga gagtcttacg tgatttgcta aggatctatg tggccttgtt aatacattac
|
176041agtcttgcca gaaccttact cttggccact gcactgtcag cctcttacaa gggcgccatt
|
176101accccctcac aatgagtttt gcctccagaa ctagaataac ctgaacactt cctttcttgg
|
176161aggcactaga acacttcctt tcttggaggt ttctatcagc atcaccaact tgctagctaa
|
176221tcttagctat ttcttttctt tgtgcctcag tatcccaaac tgccaaatag cccagaaata
|
176281aaccttctta tcacagagcc acctctcagt aactcaaaaa aagttaatat ggggcttcct
|
176341gaaaatatgc catcagagaa atacaaaatg tcattatgca gtttagaaac caaatccatc
|
176401ccaaatgtga gcaaggggcg atggacttga agaggccctg tggttctgaa catcaactaa
|
176461ggcagaaaaa gagaaatgcc agaaagtcat aaactaaagg gtcagattaa agaatcccag
|
176521aatgttagac actgtctagt ctggtgcctg gttttattgc aaaggaaatc aataaccagg
|
176581ccaggtgcag tggctcacgc ctgtaatgcc aacattttgg gaagccgagg cgggtggatc
|
176641acctgaggtc aggagttcga gactagcctg gccaacttgg tgaaactcca tttctactaa
|
176701aaatacaaaa aattagccag gcatggtggt gcatgcctgt agtcccagct actcaggagg
|
176761ctgaggcagg agaatcgctt aaacccggga agcggaggtt gcagtgagcc gagattgtgc
|
176821cattgcactc caacctgggc aacagagcga gactccacct aaaaaaaaaa aagaaaaaga
|
176881aaatcaataa ccacagaggt gaggtgacgt cctcgggaca taccgaggca gagctgggat
|
176941cagatcctca gtccagactc ctagttcagg gattcctcca tcgtttatgg caagggtcaa
|
177001caaactacag cccctcggcc aaacatagcc caggactaat ttttgtaaat aaagttttat
|
177061gggaggcaag ccatgcccat ccgtttacat attgtctgtg gcagcttttg tgctgaaatg
|
177121acagagtcga gtagttccaa cagagaccat gtggcctgca aagcctaaaa tatttaccat
|
177181ctggaccttt acagaaaaag tttgccgact cctggttttt aacataagcc ttgaataatg
|
177241aaaagcctcc accctcagaa tacaaaataa tagaatagga aacctaagag tcacacagct
|
177301taagcagata gttttacaat tatctcagct tggtacaacc taataaaaac ccataaatac
|
177361agttaataat aaggaaaaca agcactagct caccctacct atttaataat tattgttaac
|
177421tacagcaagc aaaactcata gctgaaaatt cgtttgtttg cttttttcta gcctcccttg
|
177481aaagccctgt ttcatctagg aaatgctgtt ggccaatggg cgaaaggaca catcctagag
|
177541gcgcacagcc ctaatttcct cctgttgagt tgcaggctgc tgctgaggca gctgaagact
|
177601tgagagcatt gccctctctc cagagcggac tcagagagag ttgattttct ctgtcaaagg
|
177661cgatggcgcc aaaaccctcc tgtgcccctc actccagata gaaccctcag gaacagccag
|
177721gcatggaaga gactgtcttt atggcttcct ctccctactg ggcctccatg ccctgcttaY
|
177781acccctttcc tccccagaaa gtgatcagga tatgcacacg gcccacagaa gcccagccca
|
177841cagctatgcc atcattctat catcccatgg aatagggaaa agcgggtctg cccctgttag
|
177901gctgatgtgg gaatcaagag acctggattc cagattggag ttggaactta gtcactttgg
|
177961gtttttggca aatctctcaa gccctctggg cccaggtctc ccacgtcaaa tggagagatc
|
178021gtcttcacat attccaaatg atggaacacg ggcagagcca aattaagggg tggggcaggc
|
178081caaccacgtg gcacccgggc tccagtctct aatcacacta agtcattaSc aggaacatag
|
178141aaaggtttac tagtgtcact caggcagaga actttgagaa ataggacctg gctttcatgg
|
178201aatagtccag ttcgcatcaa ggtcccactg taatgattat tacacttttc cctctcaaaa
|
178261gcgcccttgc ttggctgata aatgataaag tcaccctact aataagctgt ttgtggtggg
|
178321agtgaggtga gacacgtggc ccaaggcacg gacagtaatg gcaatacatg ggcttctaag
|
178381gaagacaagt tcagtttggt caagaggtgg ggtgcaggtc cggggccaga actgagctgc
|
178441taaggacaag agaggagagg ctgcctctgg tggcccggct tctccatttg ccatgcacac
|
178501agcctttgcc tcttctttta tttgtcaaat atttagagaa tattcgccaa agtgtgagct
|
178561ccccaggagg cccacaggtg ctggagagaa gagagggctt tggagagtac tgtaaggtga
|
178621aagaaaccta ccaacaggtg cctaactgcc tggccatgct aagcgcctga gccctgggac
|
178681agggtatgat ccMagccctt cacagtgcct gaccctgacg ggcatgcact tggtaagtgt
|
178741tcattctggg gacctggaac aagcgaagct caagccctcc ttctgttctt ggaaaactcc
|
178801tcctccccat ggcagctgca tctcgaccac caatcctact ggaccacagg atgcaggagg
|
178861actacactgt gtcctggatc tcgtcattac aagagcagga ggtgagcact gagaaagatc
|
178921cagaagaact catgcaagca gaggctgtgg tctgtgggga ggagggccgg gcagggcagc
|
178981ggaccagagg aagaagcaac aaagaaggaa ggggaagagg aggaggagga ggaggggggc
|
179041cgcagagtca ctgtgggtgg agggagagca ccgccagcac atgccccaca gccatcaata
|
179101tctcttcgga ggacagatta tctggggaat ttatgctctc taataattac cttgcagagg
|
179161gttccactta tcttaccaga ggaatctgcc agttgccaga cacacaggat tctagtcaat
|
179221tccatccaca ctgccctccc cctctgccct cctccccacc tccctggctc ctgacttctg
|
179281acctctgaat tctaaccttt ctttgcctct ccagtctagg gggaRgttga tggtggaagg
|
179341gtcacaacaa cttttaacag atgtaaaggc caacaaaggg gttggtgggt tgtcccttat
|
179401cagtagatat gagagttaac gtcccaaagt tgaggccagg cctgaggaag tataggctct
|
179461tgccaaagac agtgtgtgaa gggccaagca atgctttggg gcagactgac Wtgattattt
|
179521ttgtcttcac ctgatgccat cagacctggt taggattaat tttatcttct agtcttcaca
|
179581tccctcctca aagccttcct atccccaStc cagccctcca gtgaggcctc cctccaataa
|
179641tggYgtggct acttattcga aaaccatcac gtgttgcttt gggttgctgt ggtttcttta
|
179701aacgcacgtt gcagtcctgg ctgtgagctc ctggagaaca tgggtactgc atccgtactg
|
179761aatcaggact acctgagcaa cagtaacaac atccagatgg ccctgacRgt gggcgggaca
|
179821gtgccctccc tgcttagaaa caggaaccac atttcatctc cacaacaacc ctatgaaaga
|
179881gatgctacta ctacccctca ttatacagct gaggacctgg gagctcagac agcttcagtc
|
179941acaggcccac ggtcacttgg tcagtggcca agtcaggatt tgaaccaggt ggtcttgttt
|
180001cagagtctgg gctcttaacc actccacacc acgctgcctc Ygtaggagag gtttgctgac
|
180061tgattcggac attttgtgtt gtatctatcc gcttatttaa gtcatccttt tctaaaataa
|
180121taattttttt tgagacatgg tctcgctctg tcactcaggc tgtgcaggag ctctgtcact
|
180181caggagtgca gtggcatggc tcactgcagc ctcgatcttc agagctcaag caattcacct
|
180241acttagctac cccagtagct aggactacag gcatgtgcca ccattcccag ctaatttttt
|
180301tttctttttt taagagagat cgtgtctcac tttgttgccc aggctggtct caaactcctg
|
180361gactcaagtg atccacctgc ctcagcttcc caaagtgctg ctgggattac aggcatgagc
|
180421ctgggtgcac ctgggctggt gctcctcctc cttaggactc cactcactgc tccctcctca
|
180481gggggcctcc cccaaactcc ttagctctgg cactcattct ttttccatca ctctggcacg
|
180541atgccaacta tcaaaaatta ttttataggc taggtgtggg tggctcatgc ctgtaatccc
|
180601agcactttgg gaggccaagg caggcagatt gcttgagccc aggagttcaa gaccagcctg
|
180661ggcaacatag tgagacctct tccctactta aaattaatta attggccagg cacaatggct
|
180721catgcctgta atcctagcac tttgggaggc cgagatggga ggactgcttg agaccaggaa
|
180781ctcgagacca gcctggtcaa caaagcgaga ccccatctct taaaaaataa taataaataa
|
180841aaaataatta attaatgtat atgtttattt actacctgct tttctcaata gatataaaag
|
180901cttcctggga gaaagactgg tctaatttgt tcacccctct atcaccagtg cctaaagctg
|
180961gtccctagca tatagtaggc actatataaa tatgagttgg atgaatgaat tgtctgatgt
|
181021ccccactgag cattccataa tacatgatgg ctacttaatt ggacacttta ttttatgcaa
|
181081actcatctat ctgttcttta tttattagac tttacagtgt accaggcacc ttgctgagta
|
181141ggttaggatt tcactgtacc ctgatatgag gtagagaata ttgtctttat cattctcatg
|
181201ttacagatga ggaaactgag actcagaggt tacacagctt gcccaagacc atacagaaat
|
181261agggtaagac ttaaccccca ttctgtcagt ccccctgagt ccatgatatt aagcattctg
|
181321cctcattgcc tctggctggg tcccctcagt aacatgattc tctttacccc tgaacctcta
|
181381aaatgtcccc agccttactt ctcccccctc aagagccccR tcRcctcttt ctctggcctc
|
181441tgtgtgctgg ctctcctcca ttggtccctc cagattctct ctctgccatt cttttccctg
|
181501ctgggtgctg cggaagtctg tcctgtatgg tcagccattt gccctcttcc ctctgctcct
|
181561ggtggtctgg gtcaatggca ggtgccgaga gagggaagag agacagggga tttcctctcc
|
181621ccgccccttc ctgctgtgga gtgtctgcat ctgcccactg aaggtcacag ctcctgtggg
|
181681ccagccctct tcatacagct acctctgcaa tctggtgacc ttccccactc ccccgaccta
|
181741gccctaggct gctgcactag ccccccacca tgtgagtccc tgcccgcagt tttgaaacta
|
181801gacatgttac taaacactcc tcagtttact tcgtgtggag ctgctgcttt gctggaaccc
|
181861tgcctctcgg acatatgagt gctacatggc ctctgcccct cccccaggtc ccccaccact
|
181921gccgctgccc cYtggtcact gcagctgcct caccaggccc ttctttgctg ccagggtttg
|
181981ttctctgtct cYaagaccta taaataaatg ttgatttgct ggcttgaagg tttgccctgg
|
182041cagccccacc agggagagca gtgccctggg gagcccagca agcccacagc aagctgtcct
|
182101cccaagacta ggagaaagca gagagcatcg ggtccaatgc aggggtcccc tatgctcgga
|
182161gcttccccct gtgcggggtg ttaagggacc cctcagatga tgtcctggtg cctcaaacaa
|
182221agccgccatc acagcttcaa aatcacaRta tcatttgttg agcaactact atgtggcagg
|
182281ttctgggttg ccatttgcat acattcactt tcatgttaaa agacgagaaa aacaRgttca
|
182341cagaggttaa ggaatttaac caaaacctca aaactactaa gtggatgaac tggaattaga
|
182401tcccaggtca gcccaaatct ataaggcctt aattccccac cagtacatgc tgcctcatga
|
182461ccgatccctt tgaatgacag gaggcccaca gactcgaacc tagtccaggc aggcagctca
|
182521gagatgccag ccacccatgg ctgggaggag atcaggtgga gcaggatgac agttaggata
|
182581aagggcacag agggctccat gctgcctaga gtcactttgt ccaaggacca tggcacagtt
|
182641tggccatagt gactgctgag cagccagggg gctggaacat gccccccacc cccgccccca
|
182701accccgaccc actgctcctt cctgcagagc cagccaggag ccatcactcg tccttgggca
|
182761cacaccagca tttcaagaaa acaagcctgc aagcacagac ccctctgagt caggcccagg
|
182821actgtcacga ggagactctg aaggggaggg gagggacagg gtgacacaaa gagggggaag
|
182881gcctcctgcc gctggacctg gagccgactg tgcttcccta agtcctttct gcagccaaaa
|
182941ggcacattcc ctgagaacac cgctcaagat ccaaaggctt tcgcttttta ttttttagga
|
183001agcaatggca aaaaaagaaa agaaaaaaag aaagaaaaga aaagaaaaag aaatccacat
|
183061ttctagtgtt gggagcgatt cttggaggca aacacactct cttgcacaca cacaccccac
|
183121agcgcttccc ccacacagcc caaaatagtc cacaccatgg actcctggag aacccggctc
|
183181agcacagcct cccgaccttg gtccacatga ctgctggcca gctctcagtc cccagggtaa
|
183241caaagtactc caaggacccg Sagtagcagc gcctgctcct acagaccatt tcacccctcc
|
183301cagcgaagtc ccatctgctg tgtctcgatg gagccaggtc cagttagcag aggccacttc
|
183361caatgaccca gtgtggccca aatctccaga gctgacctga acctctctcc ctcaacccct
|
183421ccaaatctta gattgctgct gctgcttctc caggggaatg gctcccacaa cattttatag
|
183481actgcaagga aaatatccag aactgagacc gttcttcaaa ataataattt aaaaaaaaaa
|
183541aacactgctg aaacacagaa ctgggtgtta tcttaaaatc tctgcacaaa tagaatttga
|
183601atgctctcac tccaatcaaa atcattctcc gtccctccct ttaaacactg aaagttcaat
|
183661tccccctaaa gacaggattg caaacatgat taggtccaat taatttatgg agaaactcag
|
183721aatgaaagga gagaaatcaa tagaactgcc ttgttctgat cactaccgca aatgaagtaa
|
183781taatttgaag gagatctgga aagaaaggaa accaaaagtg tcacaccgca gccattggcc
|
183841atttaacaag gcagcattgc cccatgtgga ctggctgggt ggagaagacc actcaagctt
|
183901acaagacact cctggggaca gagggagggg agagacagct gaggtcactt gctttctctt
|
183961cattgtacag catgaggctc actggtggta aattctcctc tttctcacaa aagcaagacg
|
184021taaaagaaag taaaaggcaa aaagcatcca cacaagctgc cagtctaata aggacactgg
|
184081taatctccag gcaggccaag gccatatggg ctccccctgc agcttcatgc taagtttatc
|
184141tccatcctca cactctacct ccatctctct tccatatcca ggaaggaaaa aaggaaatta
|
184201acaagccggc atccaacatc catcctgaat caccagctgg gccatgtaga gcatccaaag
|
184261atggggtRgg gaagccccag gggagagaga gacattgaca gatcaccgtc cccacctctc
|
184321acttgcctgc agctcccttg catagatgat gctggcaaat tcaacRtgat tttcattgga
|
184381cctgcccagc agtccagatg tgggagccta ataacaaata acaatgccag ctccatgtga
|
184441tccttgcacc ttcaagagaa aatgccttgc tggccagctg ggttctctgg ccaccctcca
|
184501gcccaccttg ctgcttctgg atggaggttc gtgaagctgc tcctggccta tccaaatggc
|
184561cagtaaacat taacattcat ccagtcaggc aacatccatg gagtgcctat tccatgccat
|
184621gctgccccat gtgggaggca gcaaagcgct tcagtgaaag gctggggcac tggcatgagg
|
184681acaccaggtt tgagtcccag ctccttgctt acttgctgtc tgagctgttg aactctgtga
|
184741gcttcactac cctcagctgc aaaatgggta tgataataag acccttctca tggcttcact
|
184801gacaagaaca aatgaggtga cctcactatg ggtgatcagt aaatattagt ggttRttacc
|
184861acaatgtggg gtcctaccct ccactcattg ccaccaccag tgccagaaaa agccagctca
|
184921tgagttaact cccaggcagt attatccact ccaggggcct ctctgtccac acagatgagc
|
184981agaagcagaa tgcatgaaaa aataaaatag ctcaatgcca ttgctacaga ttgccccacc
|
185041accaccatct caccagtcag cttcaagcca gcggggtcag cagtcagaag cacagccaag
|
185101agtgtgggga tgattccgtg acaaaccatc cccagcagca gaaacctatc tcacagcaca
|
185161catcctccca gaagtgggtc aagggcatcc attgcctttg tttaaaggca ctgggtcaca
|
185221aaggaggagg agccttagca ggttggaact ttgggatatt ccacaggaca ggtagaaggg
|
185281tgctgtgttg gttttctatt gctgctgaga caaattacta caaactttgt agtttatgaa
|
185341aacacaaatg tacgatttta cggttctaga ggtcagaaat ccaaaacgag tcctaaggct
|
185401aaaaatccag gcatcagcag ggctgtattc cttttggaag ctctaaggga gcagtttctt
|
185461ccttgacttt tccagtttcc agcagctggt ggcctcttcc tcccatgtgt cacttctacc
|
185521tccacttcca aYgtcatatc tccagctctg actctgaccg tcctgtctcc ctcttgcaag
|
185581gacccttgtg attacactgg actcacccac ataagccagg ataatctcct caYctcaaag
|
185641tccttaactt aatcacacct gcaaaatccc tcataccatg taaggtaaca tattcatagg
|
185701ttccaaggat taggacRtgg acatctttgg gggtaaggtc acgcttctat ctaccaaagg
|
185761cgtgttctgc tgctgctgca aggtacactt gaataccgtc aaagcaatgg tgaagaattg
|
185821aaagaaacgc agttatgtcc taagcccagg aatattgaag ctgtcctctt tttgacaaaa
|
185881aaaaaaaaaa aaaaatatat atatatatat atatataagg cagatggtgc ctaagagcat
|
185941aggatttgga accacatcgc tctgggttca aatctaagct tcaccaccag tcccagctga
|
186001agctattcaa gaccagaagc tcatctgtgt gaacttccat tttcccaaca ttgtagggtt
|
186061gatgtatcct aaggaataaa gaacaaaatg cacgcagaat ctttcacacc atgtctggca
|
186121cacagtgaat gcttagtaaa tggcaactaa gaaattgctc ggtactgtta ttctattagt
|
186181ttggttctat cagacccagt cactaaataa accagtttga cgtgaagtac ttggctatca
|
186241gcaaatacta ccaggccctg tcaagtccca ggaatcagag gggctgtttg gccaatgcag
|
186301actgaccctt tcatgctgac gtcagggagc cccagcagag acaaccaaag atctagagac
|
186361atgatcaaaa tttccctgtc aggacatggt ccagaaccat ggatctcagt ttactttccg
|
186421cagaaagaag aagaaaaggt gaagcccgca cacttctctc ttccacaaac tcaggcccca
|
186481ttcccttgta cgtctttctc ttataaacaa ttgcacttta ttttcaattg tgttgtgata
|
186541aatttgagct atagcttaca gtcaacaatt tctatcacaa atctttctgc cttccaattc
|
186601tgtgtatgta caaactgagg ctaggaccaa aggaacRaag actttatctt acatgaatca
|
186661tttgattcca ttactgaaat ctctcaggtg aagttaaaat atatatacac tgggtctata
|
186721ttagaatata tgagacttga atttgatctg ctaattagct gggtgacttt aagaaagtat
|
186781gtaacttatc tgagcatccc tttccccatc tataaaagga ggcagaggcc aggtgcagtg
|
186841gctcatgcct gtaattccag aaggcggagg caggcagatc acttgagctc aggagtttga
|
186901gaccagcctg gacaacatgg cagaacccca tctctaccaa aaatacaaaa aattagccag
|
186961gcatagtggc atgggcctgt ggtcccagct actcaggagg ctgaggtggR agaatcactt
|
187021gagcccggga ggcggaggtt acaataagcc aagatcatgc cactgcactc cagcctgggt
|
187081tacagagtga gatttattta tcactaaata aataaataaa taaatggaga caggaaaatc
|
187141tgcctcttaa gactacagca tgggttaaat agcatgtaaa acctttggca tgttggattt
|
187201ctagagcatg tactatgtct cagacactac aataaacatt gtatgtgcat taattcattg
|
187261aatcctaata acaactctat gaggtgctgt ttattattcc tattttccta gaaagtagac
|
187321ctcttggggc cagggatagt ttttttcatc ttcaactccc aactcaWata ccctgtgagt
|
187381ggtaaatgca agctacaact atcattgtcg atagttgagt ctggaatcac cgcagacgat
|
187441tttataaaga tggaccccaa gaggtaggga ggtttagaga aaaggaggaa ggagagtgtg
|
187501caggtcttcc caatggggta aggYRaggca tgaggaagtg acaagaaatg ccaagccagt
|
187561aagaagacag gacgaagcat cgcacctgga tagaagacta agtaaaacta ccttcctgtg
|
187621gctaaggggt ctactaggat acactcattg acttgctttg gccaacagaa tacagtggaa
|
187681gttagattac accagttcca agctcaggcc tcaagaggcc ttgcaagctt cccttctgct
|
187741ctccgggaac cctgcctagt tgcttagcat atgaatacgc ttgggctagc ctgctggaga
|
187801atgagcagac acagaacaca aacaagctat cctagatgaa gctattcatc taggacaagc
|
187861tgactgcaga cacataggtt aaccagccca aatcagaaga accagctagc tgagcccaaa
|
187921tcgaattgcc gacccacgga atagtaagca aaataaatgg ttgctatttg aagccattaa
|
187981gctttatggt gttttggtat gctgcaaaac taacagaggc aggagtcaat gtctcattca
|
188041tctttatatc ttcaacagcc aataaaagtc ctggcatgta atagttacac agtaaacgct
|
188101tcatgaataa agtattgaac tgatatatca atacagctgt gaataaataa atgtcatatg
|
188161ctggaaaact gaaatcatgt aagatcgcat aattctattg agatacttca gcttaaagaa
|
188221tatttttaaa tggggttggc tgctacctaa ttttaaaatc cattttcttt tttcttccta
|
188281gccaacatcc ttttccacaa agtttagtca aatagaaaag aaagtttcac atgaacatac
|
188341aacgtaggat gYggtgatcR aaaactagac tggttgctta gagatccgag ttctagactc
|
188401aactctccca ataactggga gaccttgcta attctcttaa ttaccatttc tacgtctata
|
188461aaatagatat taaaaaatta cccttccctg tcaacctcac agggttgttg tagcaaataa
|
188521gacagcatgg gaaggctctg agcacttttt accgtcaatg attctacttc cagccaggct
|
188581cagtggctct tgcctgtaat cccagcactt tgggagtctg aggtgggtgg atcacctgag
|
188641gtcgggagtt caagaccagc ctggctaaaa cggtgaaacc ctgtctccac caaaaataca
|
188701aaagtagttg ggtgtggtgg caggcgcctg taatcccagc tactcaggag gctgaggcag
|
188761gagaattgat tgaacccggg aggtggaggt tgcagtgagc caggatcgca ccacggcact
|
188821ctagccaggg aagacagagc tagccttcat ctcaaaaaaa aaaaaaaaaa aaaaaaaaaa
|
188881aagattctac ttcctctata agcagaactt tactttttga tggtttctag tgtttttata
|
188941atatatcctc ttaagagccc catttatcct tttgctgtct tccttttaat attctgtatc
|
189001ccagtagcca tattttcaac atacatacat aYatacatgt atgaaaccaa gataggaaat
|
189061ggttaaaatt atccttgata gtggagaaaa ctattgctct atccaaagag agctggtatt
|
189121tctggcactg aggattacat gtgaccaagg tcagacatga tacctgcaag atgtatcctc
|
189181tagctccaga gttcccatgg agaactcggg gtccctagtt ggctgcagca ggggctgcca
|
189241gctgctaagg atgcagccag atccctttcc ctttccagag acttctgccc agtatgggaa
|
189301gtcagaagct ccacactcca agtatggctc ttccacaacc tcagttcctg ccttgggcca
|
189361agtcttgaga tcagtgtagc tgagctccga gcccaggtct ggcactgcta aatggaaatc
|
189421cttcatcttg gcaactcctt ccaYaatggY agaaccaggt tggaagttca caaggtgctc
|
189481caggcatatc agggcttact gccctctcct aaagctcccg aaacctttgg aagtcacagt
|
189541tctggagtaa acatcaggtg tcctcatacc caagcatctc aggagtgtgc aggaggcagc
|
189601agaaggtagc ctgtgtcctg aggcagtgca ttctccccat cccatgaatg atggggctgg
|
189661acagaagaca tcagggacag caactcaaac cactgggcag gtggggctga atggatgggc
|
189721aacactggcc gtgctcaggg ctctgggtct tccttgacag tgcaattgta atacctccat
|
189781ccttccatca acccatcctc cctatggtgg acataggttg tctgcctgcc cagataccat
|
189841tctacctcct tctagtaaca atacctccat tttctacctc tccctcacta tcagttgtgt
|
189901aaaatcaacc ccactctacc ctccaacttc agagacaggc ttgtgactag gcctggccaa
|
189961taagaaaacc ggccatgttc tagccagcca tggtgactca cacctataat cctagcactt
|
190021tgggaggctg aggaaggagg attatttgag gccaggagtt caagaccagc ctgggtaaca
|
190081tagtgagacc ttgtctctac aaaaattggc caggcatggt gatgcacacc tgtagtccca
|
190141gctactctag aggctgaggt aagaggatcg cttgagccca gtgagccacg attgcaccac
|
190201agcactccaa cctgggcaac agagcaagat catatatgta tatatatata tatgagaaag
|
190261agacccacat cccttagtga tccgttcaag agtgatcagt tcaagggtga aaatgtggtc
|
190321tgaggcaggc aaattagagt caatcctgga acttctgggg gaaagaggca ctttctttct
|
190381cttagtatgg aaaggcagat aacaatatat acctgaagca gctgggagcc Mcccatcaag
|
190441caggcctgtt tacaaaggat gccaatgtaa agaaaagtgg agtttagaga tgaaggagag
|
190501atggagggag tcaagaggac cttgctgagc ccctagaccg agtcacgagt gaagaagata
|
190561cactcacgag ctgttagtta catgagccca cacattcctc tgtgtgctta agcactatga
|
190621gttgagtttc ttgccatttg caaccttaaa aagccctgcc tgatgcacat cccaccattt
|
190681gatgttacca acagactcta ataaggctga ggaagaaccc aggggcccca tccaaatacc
|
190741tctaggctgc ttgaactcaa atgcttttga aataaggatg gttcactgtg gctgtcagat
|
190801gccacacatc aaWcctgaaa ggaaattcta gccagggaat gctacagatg gcagctcacc
|
190861acggccccca ccactcctta ttgtctttgt caagcccatt tcctcattta ctttacctgc
|
190921ctggtccctt taaatacata agtttaccat cccttattag atggataaat agataaatgg
|
190981atRgatggat ggatggatgg atggatggat ggatggatgg acggacacat ggatggatgc
|
191041atggatgcat ggatggatgg atggacacat ggatgcatgg atgcttggat ggatggatgg
|
191101atgcatggat ggatggatgg ttgcatggat ggatggatgc acagatggat gtatggatgc
|
191161atggatgcat gcatgcatgg atggatggat gtgtgcatga atgaatgcat gcatgcacag
|
191221atggatgcat ggatgcacag atggatgcat ggatggatgc atggatgaac ggatgcatgg
|
191281atggatgcat gaatggacgg atgcatggag gaatggatgg atggatagat gcatgggtgg
|
191341atgcatggat gggtgcatgg gtggatgcat gagtggatgc atgggtggat gcagggatgg
|
191401atgcatagat ggataggcag acaagcaagc agttatgtag ttgcaagttg aacctacaca
|
191461caaataggca tgatacaact aaagaattaa aaYggcagcc cactgcagtc agggggccat
|
191521ctgacaatat aggaaaggag ataactatag gcttacttct gtatggtttt gggtgtctgg
|
191581aataacgRga gatgactctc tgggtagcac tcaccctgta gttgtgctcc tccctctcaa
|
191641gccacagtgg ttaacaccac cttaccaata gtgcagtaca aagagaagcc agtcctggca
|
191701ttcacaggta gctgtgaaaa gctggcccta aaaggcagtc tcgctcaatc cccagcatct
|
191761actYggatct gggcaggcag ccacagaaac agaagaagct acagaggatg Saggcactgg
|
191821gttttggtgt ctggacatgg aagaattgca ggccaatatc cacaaatgta tccgtgaggc
|
191881tctggtcttg aaacaaggat gtgaggaccc caggatggct ggtgagggac actaagtggc
|
191941tcaaagaact gagaaaaaaa taaaaacata gcagcaatag agaccagagt ccgagccagg
|
192001acaaggcctg tccctcagcc acctggctga aggcatcatc atgacctcaa ggaggtaact
|
192061ggtgagtcat acagaaccac actgtgcact cttcaccatg gtttatatgc tcacagttca
|
192121ggcaaYtgct tagaaaactg catatcgttc atgcccctat gaatcacttt cctccttttg
|
192181ttgtctttgt gaagtcatca caaagttctg agtggaagaa ttcttccagg gactgccaag
|
192241gagtgacact gtagccaggt gggttcagct ctcactttgc tcaggatatg ggtgtccagt
|
192301ggcgacagat caggaaaata gccccatact aaatggtgcc tggacaaggc ccataMacac
|
192361ttggatatgc tgtcctgaac acaaggcaca agacacaaca cgggaggacc tttcatctca
|
192421tgtctcttac agccagggac tgaaggtgta ggacagtagg agaaaataga gtttcacata
|
192481aaacacccca aggacatcaa agaaggctag ctgccaagag gtaggaagaa ctagattctt
|
192541agggacttat ccttggggat tgataccacc cctgccaggc atccaccttt ggggtgactc
|
192601agagccaaga aaacaaaggc atgggataag ccatggaaaa caaattcctg ctgagtagca
|
192661aagagagtgg caccaacaag tggcaccatg tgagtgacaa gagcaagcaa atgctcacac
|
192721agggacagct gggtgtgcag ggccatcaca gctcccccta cccccaccac ctgaacacta
|
192781cgagacaaat gggactcctg gtttctgccc tcaacatgct tatatttgag agaggccaca
|
192841ggaccagcga gtgcagagtc atggcgaact gtacacaacc tggagtcagg agacccatgt
|
192901tctcaccctg ttctgttgcc tcgggggccc tgaagcccat cgctaagtgt ttKgggctcc
|
192961agtttgctca tctgtcaaga gagaaccctt cacacagctc ctaagtgctg tgagtccctg
|
193021tctctcagac tggctaatct ccaagggcct gccaggtccc acatgcatgc tcttgagagt
|
193081cacatagata tcaaagctca aaattagctc ctgggagtgg gagcaaagct tctgagcccc
|
193141cagcccctcc tgtgagcaca tacctcaagg cacatgcccc caacagccca gaactgacac
|
193201atttttgata gttcctgagt acatggattt ccagccctgg aaatgtttgt tttaacttac
|
193261caggagaaaa gaatttggat tcttttttaa atatacacaa agggaataca tttgtatatt
|
193321ttcagataca aagtggatgg gaagcaaggc taaagactgt tcttttccct tagctcatgt
|
193381gagtgctatt cctcacggtg aattctccaa agaccatgaa tggcagagat ctttgatctc
|
193441ccttctagcc tgtctcgatg tgatagcctg gacatgggca gctatcacgc cacccttcag
|
193501aacctcagca cttcaatgac cacatcctgc catcatcacc cccatggagg tccagggccc
|
193561ctgccccact gcctacctct ccacctgtgc ccacctctcc acctacccgc cccttgtcac
|
193621attgacagat aaaatacagg actcccagtt aaatgcaagt gtcagatgga gaacaaataa
|
193681tattttagta taacatgtgc cttcctaggc agcacaactg aagcaggccc cttccaagga
|
193741tagaaaagtc ctcctctctt cctaagtttg tgtccataga atctcatcca gtggcctttc
|
193801tgtcccctgg cttcaaatga aacctgccac tgcctctctc tcagggtgaa gtgtgaagac
|
193861cgtggcttcc aaggccaata ggcatggagg tagtcatccc attcagacgc caatggttct
|
193921tagtcaaaaa agctgcttat ggctggagtc aaaaacatgt ctaagcgtga ctatcagccc
|
193981cagtgcagaa gagtctgggg agagggagaa acaagaaaca gatattacca caaaacactc
|
194041caagggaaat ctcactacaa aaaaagaggt tgttgcctgg tgatggctgg caatgggcca
|
194101tgaaaaccta gttctgattt ttagatacaa gaSacaagcc caacgtgtca cccagcctgg
|
194161atcccataga ggtcacatgg acaaaacagt acttgaagat ctttgacctg cctaggtggg
|
194221caactggagt ggaagctcca caagggtatg aatgctgtct tttgttttcc tcatctctat
|
194281ggactagtcc atctagtcca ggactagcct cagagtgagc atccgatgat cgtaggaaga
|
194341ctgaatgaat gcgtgaacac atgaatgaat gcctacattc tccaatatgt cccagaaagt
|
194401gtcaagagct ttgtaacgca aaaggctctg aacaactcaa ataagaaaca caaacatgtg
|
194461cagtgaaagg gctaggcctg gatggcctgt gaggtcattg gcaatgtggt gagcccttga
|
194521gcctgtcata cacaggcaaa taacttcact gaaagaattt taaacgctac ctccaacacc
|
194581ctagctcagc atctatggtt gaagccacca tgcccagtca tggtgataac cccagaaggg
|
194641aagggtgcag agacgccaag aaacaagaac ttggagagga caatgaggac caaatgactg
|
194701gggaaataag ggatgagtgg gtaggaatcc aaagaacaga ataggaaaaa taactcaaga
|
194761tccagcactg ctttccagga cacacacaca cacacacaca cacacacaca cacacacaca
|
194821cacgcagaca aagattcccc ccttccagat ccacactgcg tgcctcctgc cagccccatc
|
194881ccatcatcct gtgacagtgc ttctttgtgg aatagaacaa taggtacatt atgccaacct
|
194941ataattatcc taggagaagc gatggcgaag tcaaggcatt atgtgaacac tggaatactg
|
195001gataccaccc caccaggagc aaacaacaac aaaaacaaca acaatccaca aaatctctaa
|
195061cgcagataaa gactgaaagc tgcctaagcc agtgcccttt cacattcata tgagggtggg
|
195121attttttcct tttcacatga ttatttaagc acaaggcctt ctttcatgga attgatagag
|
195181tattggggga aggggctgag aggttgggtt tgtttgtgtt tttgtttttt ttcccaataa
|
195241ggaggcagaa agtagaggag gtcgtgagca cgagaaagtg ccactgctag ggtatgacac
|
195301atagagccct caaaggtagt tgaatctgat tcWactgagt gaaatcattt cattaataga
|
195361gattccttct cactactcct gtgaaactac tttccaggga cgttggtata aaataggctg
|
195421agtcctggga ggtgtcatgg aagacagaga caagaaatca gaatatctga attcttatat
|
195481cacagccact aactagctgt ttccttgatt tattcaagag gtatgtgttc cctatctgcc
|
195541acatgctagg catcaagcta gcaacagaag gaaaaaacaa agcagtagtc actttcctct
|
195601cggagcttca gcttcctact gtgtaaaacg agggagtccc acagccctgg acacacNcac
|
195661acacacaMac acacaSacac acacacactt ctaaatacaa ggtgcagccc cagcctccca
|
195721caggacctgc ctatacaggc catgactgaa gaagggggaa acctgcagct tctaaaactg
|
195781cacagaaggc tgggcacagt ggctYacacc tgtaatccca gcactttggg agggcgaggt
|
195841gggcagatca cctgaggtcg ggagtttgag accagcctga ccaacatgga gaaaccctgt
|
195901ctctactaaa aatacaaaat tagccgggca tggtggcagg taactgtaat cccagctact
|
195961caggaggctg aggtaggaga atcacttgaa cccaggaRgc agaggttgcg gtgatctgag
|
196021atcacgccat tgcactccag cctgggcaac aagagtgaaa ctctaYctcc aaaaaaaaaa
|
196081aaactgcatg gaagcccaaa cccccagggc aaatggaaca gtcacagcat gccatgcacg
|
196141cacagggtca gagcaagagt atggccaggc gcggtggctc acacctgtaa ttccagcact
|
196201ttgggaggcc gaggtgggca gatcacttca ggtcaggagt tcaagaccag cctggccaac
|
196261aaggtgaaat cccgtctcta ctaaaaatac aaaaattagt tggacattgt aatgggcgcc
|
196321tgtaatctca gctacttggg aggcctgggt attagaatcg cttgaacctg ggaggcggag
|
196381gttgcagtga gttgagattg tgccactgca ctctNcNtgg gtgacagagc aagactctgt
|
196441ctcaaaaata aataaataaa ataacaaagg tgtgaaaagt aggatgggtg tttcctagca
|
196501catctctagt ttctgagggc tctctctaat ggggaccYtc ctcttgaatt gtggtcccat
|
196561gggttccaYc tcttctggga tccagtcagg gcttcttcct tcattctcag gcaccttcag
|
196621Mcttgaaact ccttggcctc ctttcccttc accttcctgg tgaaacataa cagagggtct
|
196681tcgagacaat tcctttaaat catcaaaggg cctatctagc aatgtctaac tccattcctt
|
196741aacgtttact gaaaagctcc tcaaatacat gatcctcccc tctacccgtt cccctcagct
|
196801cttagYcatc cttcctcaga tgStactttt tcatagggac taatttcttc cttcttgcca
|
196861aatccagtgg ccacccgtgg gtggtcctgc tgctcaacca acgtatgaca gtattagcca
|
196921tgcgctcctt gaaacactca gagccttgat tctactcatt catttagttc ctccccaaaa
|
196981gttccctgag cccctgctag gcagtgggga tttggcaata agacccagtc cttagtcctc
|
197041tgctcatctc tccacactcc gctcttatgg ctccaactct cacatcagca aagggctttc
|
197101aaagactcaa agcacctcca cactcattac ctcttgtaat aacaaaattc aactctgcaa
|
197161actttgcaaa acactttata tcgtaatcct tttttcccca cccScactgg gcgaaagaac
|
197221ctattcttgc aaccaacact atcctgaaaa tgtggaaaac ctctaatgga agtgcaacca
|
197281agtgctcctg gaattcgaca tgctttttta tgtccttccc acccctagtt ctcccctccc
|
197341tgcccactct cccttcgcac ttcgcttgcc taccttacag cagagttcat tttgtcggtc
|
197401tcttctaagt ggtgggctcc tggagggctt ccaaYggact gatctctttg tagactccat
|
197461attactcggt gcttaaatat ttgttgaaat gcagcaagat cagggagtaa ttcagcacca
|
197521attgtttacc tgatcctgga aacctcatct ctgccccctc cattccccag gagagtctgc
|
197581ccatttgaaa actgttcctg ggtttatttc tagcatggcc ctggagaggg ctgccctacc
|
197641ccgcagggtc agggaggtga gttttctctc accttgggta ctgcagagcc caccaccagt
|
197701ccaccctgaa acctcaaagc aggcccacag ggtagatatc tagggacctt gaagcaaaca
|
197761tttcacctat tcaggacaca aactaaataa gcttgtgtcg cttagtaatt ctgtaatgtc
|
197821ttacttatgc ccttgggcaa actccttaaa ataYttgttt ctgttttccc atcaataaaa
|
197881tgagaattga agcacctatt tcttaggatt attgtgaaga tttgatgaat taacactagg
|
197941aaatgtgcct agcactgttt aatatgtggc agaggctcaa taaatacatt attattatta
|
198001ttactattat tgacaggtta aaggcctgtg atgatactga ctccagcata actctgatac
|
198061tgcccctttg actcggctag ttttgacaga gggccctttg acaacaccta aaaaacaaac
|
198121cactaaactt tcagttttta aaaaaatacc aggtaagctg ggtacagttg gctcacgcct
|
198181gtaatcccag aacttgggga ggccaaggct agaggatgat aggaggatct cttgaggcca
|
198241gtttttaaca accaactctc cagYgaacta atccattcct gccagaacaa atccagtctt
|
198301acaagagtat gaatattaga gctacaaggt accgccaaga gacagggttt tgctttgttg
|
198361accaagacca gcctggtcaa cataggaaga ccccatctct acaacaaatt taaaaattag
|
198421ccaggcttgg tggcacatac atagtcctag ctactcagga ggctgaggca ggaagatcac
|
198481ttgagccctg gagttggagg ctgcagtgag ttatgatcac gccactgcat tccagcctgg
|
198541gcgacagagc aagaacctgt ctctaaaaca acaacaacaa caacaacaag taatgtgaga
|
198601aacaaatgcc ctccctccct ccctgagggt cacccccagc ctgacctgat ggatgggaaa
|
198661agataagctc agagatgggg taaggataag gtgggagtta ggaatggggt agaggtcagg
|
198721gatggactga gaactaggaa agggaaggat caaagatgga ctggaggtct ggaagcagga
|
198781agagagaaat ggagtaaggg tcagggctgg agaccagcag aaccgaggtg aaatKtagga
|
198841ccatctgatg gatggtcaca ttaataactt taatttttca ccaccagctc ccactacagc
|
198901atccaaacat cctgctctga aggagtggga gcagggacag ggaagaagaa gaaaccttaa
|
198961ctgagtgaac attttaaaac aagcaggaca tttcgaactc aaatagtaag agtcactttg
|
199021ctgtccaaat cccaccagtc cttggtgtaa tactacaagt gggacttaca agcaggaccc
|
199081gcaagaaggt tctagtaact acctcagctt gcaggacgta aaatgcctgg cgaactttgc
|
199141attccaagga caggagtctt ccaaattaaa attttaatag tgtgtgaaaa tagttcgcca
|
199201tttactctta ggatgaggta gtgtttagaa agtcagcctg gaaatccagg ccaacatttt
|
199261cagggatgcc tcctRttctg ggaggagaaa aaccagcttg ttgcttccct ccagtagcac
|
199321aaagcagcag ggaacYggaa agagagaggg gtctgaacag cttcttctac caggaaacca
|
199381gccaaaggtc tccgggcatg taaggacatc tgttttcaga agctatggtt tggattttgg
|
199441cattcttagg agtctaggag caatcctact aatttgggtt ctagctccaa ccatactacc
|
199501tacctgctgt gcgaacccag gcaagtgatt ttacctctct gagcctctgt ttgctcatct
|
199561ggccctctag acaagattaa cttggcagtg ccttgtagct ctaatattca tactctcata
|
199621agactggatt tgttctcaca ggaatgaatt agttccctgg agagttggtt gttaaaacac
|
199681cagggccccc ttgggtttcc ccatcttcac acgtgtctac tttccctttg accttccctg
|
199741ccatgttgtg atgcagaagg aaagccctcg ccagaggaca gggccatgcc cttgaacttc
|
199801tcagcctgca gaaccataag ctaaataaat ctcttttctt tataaatgat ccagttcctg
|
199861gtattccatt acagcaacac agacagacac tcccacatca tcRtcacaca gggcttgggc
|
199921tgcctggccc tggccactgc ctgccaacac caggcctggt ccctccatca tctaggacct
|
199981tggggaacat ggcaccggtg aagggcatgg gggttaYcag aaagagtgag aagtcggcag
|
200041gtcagcacgg ccacacaagc caccctctcc caacttatgt gcaggcatga tggctcccca
|
200101tccaccagca ctcctgaggc cactacacca gggaggaaag Wagtgcatgg ggaggcctgg
|
200161tcacacctgc ccttcctttc agaaccctgc atgtggctga tggcaggtcc tcggcgcctg
|
200221gtggaagaga aagggaaggt ggcactgggc tccacaggca gtgattctca gccctgcttg
|
200281tcactgggag ctggttcctg ggtcccaccc caatctctta tgattccata gatcaggagg
|
200341agacccaaga acccaacttt tcacttagct ctccagggaa taccaatgca aacggccact
|
200401gaccacccct tgagcgccct gtggatgaga gggtggaact agaggttcta gaagcaagtg
|
200461cttgagtccc ctcactagct gaatgactct gggcagttta catctccttt caaaccctca
|
200521actgcccatc tgagaaatgg ggatataaaa gYgtctgctt cttggggtta tttagagaaa
|
200581tacatgagaa aaaggatgga aagcacttag cactgtgcct gtacatgttg agaatctata
|
200641agagaagatc ccctcttact attcaggggt gacttgtaca aatgccttct tccatagcaa
|
200701tcccttacta aactggagca tttcataggg aagatgcgaa taagggcaat gaagcctcag
|
200761atacagaggg cagcggagtg ctgagacacc tccgtgccct cccacaacat cccagtgctg
|
200821tggtccagca acatacccgc cccatccctc caactcagaa catgctcRtt gatgtgcctg
|
200881aacccaggct aaatgggagc acacctatag tgggggttcc cctgtcagag atatgcactg
|
200941caagggcctg cggtccagga cacagaggaa ggaagagacg ggMggagaaY gtgaatcaca
|
201001ttcatgccag ggtgtgttct aatacgtcag caaatgtgta ccgaScttcc gggctgcaga
|
201061ggaaggtggg cgtgtgtggg gttagtgact tgaagggaaa gaggggcatg aaaaagaagg
|
201121gggtgaagag ttagaactgg tgcagcagct gggtctcaca cacaaatggc atgactctac
|
201181ttcacaggaa ctactcagaa agggaaaaga ataactctaa gaaacaaaga tctgcctcca
|
201241aatccaagaa tggcagtaga aaatagggtc ccccacccag caagcaccca catcacgttt
|
201301catcagaaga actctctatt ctcagccagg cctggcacac tgccttgacc ttcccgatcc
|
201361tggagctggg ccctgggctc agaagacccc agactgtcat tgctggaaac agaatcattg
|
201421cagatatagt tagtcaagat gaagtcacac tggaatagag tgagccctaa tcttacagga
|
201481ctagtgagtt agtccatttg tattactata aaggaatgcc taagacttgg taatttgtaa
|
201541agaaaagagg tatatttcac agttctgcag gctgtagagc aaccacggtg ccggcatctg
|
201601cttctggtga ggcttcagga agctacaatc atggcggaag gtgaaaagga gagcaggcgt
|
201661gtcacatggt gagagcaaga ccaaggcagc aagggtggga agtcccagac tttcaaacaa
|
201721ccagatcttg tgtgaactaa ctgggtgaga cttcactcat caccaagtgg acggtgctaa
|
201781gccattcgtg agagatccac cctcatggtc taataatctc ccaccaggcc tcacctccaa
|
201841cattgggaat cacatttcag catgagcttt gcaggggaca aacattcaaa tcatatcaat
|
201901tagtgtcctt ataaaaaagg gaagtttgcc ccatgaagga agagattggg gtgatgtgcc
|
201961tacaaagcaa ggaatgccaa agataagact gccagccaag ccccagaagc cagcagagag
|
202021gcctggaaca gattcttcct cacagccctc agaaggaacc aaccttgcca acaccttgat
|
202081cttggacttt tagcctccag actatgataa aataaatttc tgtgaagtta cccagtctgt
|
202141ggcacttaca gccaccctaa caaactaata cacccagaac cttactatcc ttcaccacac
|
202201cgatcaccaa tgaggcaagt cagaaatttc caaaaagtct ccacatttat ttttctaccc
|
202261aataaaccag acatgataga ggaattcaaa tataaacaag acataggccc tgccttccag
|
202321agctcctagg cacacaaatg ttagtcactt tacactttgc aaaacacttt cacatatatt
|
202381gtctcttgta gatcccccca tctcacattg agatgggaag ggcaaSctgt aggttactcc
|
202441cattctgcag atgagaacac tgagttttgg agagttggtg gcttgctcca gggcacccag
|
202501ccctggagcg gcagagaggg agctgcagta aagtcttgag tccaagacaa cattggtgtg
|
202561gctgttttct ttcagcctgt cttgctgcct ctcctgccgt cttggaacct cttgcctcct
|
202621tcaaacagaa gcccctgcac tgaggtctct tgtatctaag atctgcccca agtgagctcc
|
202681aggaggcaag gagggaggcc agccatgtta aagaccaagt taaagaccaa agtggctgca
|
202741gcaccatgag ataccagtgt agtcccccac cttctctcat agtcccttac cctgaggctg
|
202801ctcccaccag ccccgcttac ctttttccca tccccacccc Mggcccccag cctctcccat
|
202861cccacaggca gggcaggttc ctggtaacag cattgcccag tgttgtcaaa atagcgagga
|
202921gctggaaaga attccagaat gaaatctatg tgcctctgca gcctcccaac tgactgCCac
|
202981tgtggcagct aaacccgcta atgtgctaag cgttttctgg cagggccagg aggcagggtt
|
203041ggtattttgg gagctgggag gggcttggag gcaacatcct cggcaagtct gggaaggagg
|
203101tggaggcagg gaggcaaagg gaaccgaccc agaacacttc ccatgacgtc accgagagcc
|
203161acctgagctg cacctcagga ttcctgaaac actgctggcg gagcggagag tacggagagt
|
203221acgctgggcc cggtgggcag ggctcagcag ggcatggagg ctttgtagct aggcctgggg
|
203281ggagagggcg ctctagtatg ccacttgtca Ygtacacttt ttctgctgac acagagcagt
|
203341gtgcaatgcg tccgggaggc tgggcagccc agggctggcc caagctctgt ttgcctgagt
|
203401tggcagtggc agggcccatg gtgaccaaac aaaagacggg aagccaaacg cccagaggct
|
203461ggcgggtgag gctccctgag agggctctga ggatacaggc actggcgaag aagggccagg
|
203521ggctcatagg gataggaatg ggKttggggg caatgggaac ttgcaggcag ggtcccctct
|
203581ggtttcccag acacaccgca tcgcctctgg gcatcagcct ctccacactg tccttgcttt
|
203641tcgggggctc cttcgaaaat gcttcaaacc atgacaccag gaaggggagc aaaccaccaa
|
203701atctgagatc caaacaaggt cccagcattc ctttgtccct gatgggctYg gctccaaatt
|
203761ctgggagaaa ccagagggtt ttgagagagt caggagaggg gttcagggga caaaaaatag
|
203821ggctggtgaa gaattccttc cgggagccgt ctggtagcag ggagtaccgt gggtggcaag
|
203881gccgtgctgc tcaggtgagg ggacatggtg tcattctggg aacagatgag ccagtaaaac
|
203941cctgacagga ttcaatctgg aggaaaaaaa tcccagctga taggaactgc tgagcgcttg
|
204001cagcttttaa agcccctcta gcaaaaggat ctgcaaaagY tttgcaaact ctgaccacgc
|
204061agccagtcag ccacttccca gcccacagca acgagagagt ttttgctaca tcagaacaaa
|
204121cccactcaca aatatctcat cctggcctcc cccccggcac ccattccttt tgggtctgtg
|
204181tgcctgcctt cctcagaaat gacattttgt cagagcagtg agagatagtg ttgcaggggc
|
204241caaaggcagc cagggggctg gactgcaaMt aggctcccct gctcactagc ggctgacccc
|
204301aggcagggYa cttaaccttt atgaatctca ttttttaatc tgcaaaaatg caaataatga
|
204361agctgctctt acagagttgg tgagaggact aaatgagatg atggatgctg gggctcgagc
|
204421acagaRatga ggggctccat gacggctggt ccccctcctt cccaccttcc tctccagggc
|
204481cctccggcac cataatcagt gtgggaagga tgcagaacaa tgggagttta attcagaggt
|
204541tggcgaggca aaggcatact ttaatagaat tctctctcgc ccagtacatg gtttcttgtc
|
204601caccccaccc acctttcccc atctctaccg gctgatagtc tctcagctag tagacctttt
|
204661cttgtttagc agggccactt tttttaaaaa ctccagacgg gtaccctcca tgttgcaggc
|
204721gacgtggccc tggatcactc aactgactgt catttgaatg gtgcccccag agtgaggcaa
|
204781tggtgcagcc ctcctaaggc ccttcctgag tgtccctcct tcatgaagat gattctgagg
|
204841cttcccaggc cttcaccctt ctttgaaagc ccatagcagt tcatatgcac ttctcttcta
|
204901tgctcaccaa actctgcctt catcatactt gggggatgtg tgtgagagcg agagagagag
|
204961tccagcaggg attagatctg acttttatat tctctacagt gcctggcaca atgctaacac
|
205021atttgatgag gccagaatta ccctgatacc aaaaccagtt aaagacatta ccaaaaagaa
|
205081ctttttcaat attttaattc ttacctcata ccctagataa aaattaactt gagcSgggtg
|
205141tggttgctga cacctgtaat cccagcactt tgggaggctg aagcagacgg atctcttgag
|
205201accaggagtt tgagaccagc ctggccaaca aggtgaaacc ccgtctctac taaaaatata
|
205261aaaattagYt ggtcatgatg gcaggtgcct gtaagcccag ctacttggga ggctgaggag
|
205321aaYtgcttaa ccgggaaggc agatgttgca gtgagccgag atcRcgccac tgcactccag
|
205381cctaggcgac agagcgagac tccgtctcca aaaaaaaaaa aaaattaact cgacatggat
|
205441cgtagagcta aatggaagac taaaactttc aaacttcaga aagaaaactt ggaagaaact
|
205501ttttctaacc ttgggttaag caaaaatttt cttaaatagg acataaaatg catgagtcgt
|
205561aaaggaaaaa aattgataca ttggacttca ccaacatttt aaatgtctac tctttgaaag
|
205621gcactaatat gaaaatgaaa acacaagcta cagactgaga gaaaatattt gcaaaacata
|
205681tatctgataa aggatgttta gtcagaatat ataaagaact cctaaaactc aataagaaga
|
205741caaatgactc catttctttt aaggtcaaag aactgaacag acatttcaca aaagaaaaga
|
205801tacagatggc caaaaagcac atcaaaaaaa aaaggttcaa cattattagt tagcagggaa
|
205861atgcaattaa aatcacaatg agataccgtt aaacatctat tataatggct aaaatttaaa
|
205921aggctgacaa tgccaagctc tggcaaggat atagaataac tacgactctt acacactgcg
|
205981tgtgggaatg ctaactggta cagccacttt ggaaagcagt ttggcaattt cttttaaagt
|
206041taaatataca attatatttt catttctccc agagatttgc tcaaaagaaa taaaaacata
|
206101tgtctacaca aagacctata aataggaata ttcatagcag ctttctgcat aatggccaaa
|
206161acttgggaac acccaagtgc tcatcagttg gtaaatgaat aagcaagttg ccatgcagcc
|
206221acacagtgga acgcacccat acatgcagta acatggataa gtcttaaacg catggtatca
|
206281gttcctattg ctactctaac aaattactaS aaactcagta gcttaaaaca acacagattt
|
206341actgtcttac agttctggag gtcagaacgt ccgaaatcag tctcactggg ccagcatcaa
|
206401ggtcagtttc cttatctttt tcagctccta gaagccacct gcattccttg acccatggcc
|
206461ccttcctcca aagccagttg tgttgcatct tctatctaac tgcttaaggg aacaggactt
|
206521tatcaaggca cagagccaca gcaagtatgg gaaacatata agtagttcca tatttccagg
|
206581gtgtgtaatg taacatttcR aagataagga aactgagatt cagagagatc caatatctta
|
206641cccaaggtcc aggacacagt gaaaatcatg ttcaacccta aggcctctga atccaaatcc
|
206701agagtccacg tgagccctca gacttccctg ccttgaccgt ggatagtcat ctccaccttg
|
206761tctcagagcc ctgcactccc accctWgtac actgcRccag cagctaagcc tgtggagcca
|
206821ggcagaaccc tgggcctccc cacctcccca ccctgggacc aacagattcc cagctccagc
|
206881aggataacat cataacctta ataagattga catttgcatc ctgttttata ttcatcagca
|
206941ttcttacact tacgttatgt tatctggcct tctccatcgt atgagtctaa tggtgcagat
|
207001attctccacc ccacattctc caaccctcag aaagctgagg tactttctta tacagcaagt
|
207061gggtagaagc caagatcaga accttacccc caacccaccc cttgatacca gaagagccta
|
207121ttgactcaga acaaaactca ggcaaacccc ccacctagct gagcttcccc tccttcatct
|
207181gcaggatgga aaacagggta atacctgccc tgcctatcct gatacatcag gcataaatgg
|
207241aaaaaaaaaa aaggaagtag tatgtaaaag cactttggaa atgttaaaat gctatgcaaa
|
207301ttataaggaa ctgttctgat tatactctca agaaatgtca caaattttct ccaaaagtga
|
207361ataattgtca ttacttttca acttcatccc cttgaaaagc cagtttctcc tcctgtcatc
|
207421ttttatttct ggttaaagca gagatgttat actcaacatt ccaactggaa tatcaagatc
|
207481aatctttaat tcctccttcc agcttcaccc tttctgaaat caagaacagg caattctcta
|
207541ctccacccac catctcatcc tcagtttctc ttgccatctg cccccctctg aagctagaaa
|
207601tcaccagcaa ccattttcat tcctcatccc tcYggtctct cctcagtcag agccaaccta
|
207661catgatgcaa aagcaccact ccaatcacct ctctcagagg ctcacagccc cggggggaca
|
207721gcRtccaggg gtcctccacg ggctgcccca gtgaagctct ccagcttgtc tcccatgact
|
207781caccaaccca ggtaagccta aatggccctg tttcccaaaa ctcaactctc ttcccacttt
|
207841tatgtcccca ctatatctgg aactcccttt cccactattt aattagctat gggggtagga
|
207901agaatcaaac tagaccccca gctcttacat caacctaaat atattccaag tgaatcaaag
|
207961aattgtggtt aatggctggg cacggtggct cacacctgta atcccagcac tttaagaggc
|
208021caaggYgggt ggatcacctg aggtcagagg ttcgagacca gcctggctgg gtaacatggc
|
208081aaaaccccgt ctcaactaaa aaataataat aataatacaa aaattagcca ggcatggtgg
|
208141cgcaagccgg tagtcccagc tacttaggag gccaaggcag gagaattgct tgaacccacc
|
208201cagcagatgg atgtttcagt gagccaagat tgcaccattg cactccagcc tgggcaacag
|
208261agcaagacac cacctcacaa caaaaaccac acacacacaa agaattgagg ttaaaaaaaa
|
208321tccagattat atagatgaat atctatctga tagctgaatg gggctggaat ttctaggcta
|
208381catagcaatg gagtaaatca gaggagaata aaatgaataa tagttaacat ttacctattt
|
208441tcacttcttt taactggata tccatatttt aaaagtaaac atacccttta cttcatgttg
|
208501tacacaaaaa ataacaaaat ggatcacaga atgaaagaaa tgctaaaatt agaaaaattc
|
208561cagaagaagg ccaagcacgg tggcctgtaa tcccagcact ttgggaggcc aaggtgggca
|
208621gatcacYtga ggtcacgggt ttgaaaccag cctggccaac aYggtgaaac ccctattaaa
|
208681aatacaaaaa ttagctgggc atggtggtac acacatgtaa tcccagctat tcaaatggct
|
208741gaggcacaag aatcccttga acccaggagt cagaagttgc agtgagcagt gatcgagcca
|
208801ctgcactcca gcttgggcaa cagagcgaga ctctgcctca aaaaaaaaaa caaacttcca
|
208861gaagaaaaca tggggaaaat cttcataacc ttggtgtagg caaagattct taggacacag
|
208921aaaataagaa tcacaaaagg gaaaaataac ctggacttca aaattaaaaa tttctgctct
|
208981tcaaaagaca ttgttatgct gggtgtggtg gctcatacct gtaatcccag cacactggga
|
209041gaccaagacg ggaggatcat ttgagaccag gaattccaga ccagcctggg aaacacagaa
|
209101agaccctaWc tctacaaaga agtttattaa ccaggtgtgg tggctcatgc ctgccgtccc
|
209161agctacatcg caggctgagg cgagaggact gcttgagccc acgagttcga ggttacagta
|
209221agctttgatc atgccattgc actccagtgt gggcaacaaa gaccttgtct ctaaaaagat
|
209281aaaaatttaa aaattaaaaa gacattgttt aagataggag atatggttgt acaacaatgg
|
209341gagtataatt cacaccacta aatactcaac atgattccaa tggcatcttt tatgttacgt
|
209401atattttact acaatttttt taaaagatgt tgttaagagg atgaatagac aagccacaga
|
209461ttgggagaaa tgattcatag tacatatatg tacatagtat agtcatacag tatatagata
|
209521catgtataca cagtacatat atagcacata catgtacata catacatata tgacaaagga
|
209581tctatatcca gaatatataa agaactctag caatttagta ataaggcaaa caacacaaca
|
209641aaagatttga acagaccctg cacaaaagaa gatagccaat aagcacgtga aaatatgctc
|
209701agcatcatca gtcattaggg aaatgcccac taaaactaca gYaagctacY gttcacaccc
|
209761attaaaatgg ctaaaattca aaagactggt aatgtcacct gctggtgaga atatatRgca
|
209821accaaaagca cagccactgc tgacgggaat atgcaatggt gcaaccactt tagaaaatag
|
209881tatggtagct gcttattcta aaaacatgca tttaccatat gattgagaag tttcactact
|
209941aagtatttat ccaaaagaaa tgggggaaaa tggtatgtca aaaaagagac atacacagat
|
210001gctcgtggca actttattca taatagccaa aaactggaaa caacccaaat gtccatcaac
|
210061tggtgaatga ttacaatatt ttggaaaatt catatgatga aaaactcagc aaaaaaaaag
|
210121atgttactgc attggtatca ggactgaaaa aaataaaaat aaaaattagc tgctaatgta
|
210181cacaacaatg Yggataagac ttttttttta aaaggccgag tgaaataagc tagattcaaa
|
210241agagtagata gtggtcaggc atggtggctc acatctataa tcccagcact ttggaaggcc
|
210301tggggcgagt ggattgcttg agcccaggag ttcaagacca gcctgggcRa catgggaaaa
|
210361ccccatctct actaaaaata caaaaattta gccaggtgtg gtgatatgta cctgtggtcc
|
210421cagctactag ggagactgag gtgggaggat cacttgagcc caggaggcaa aggttgcagt
|
210481gagctgagat tgcaccacta cactccaacc tgggcgacaa agtgagaact tgtcttatta
|
210541aaaaacaaaa ggtagatagt gtatgattgt gtttacatga actcttagaa tcagcaaaat
|
210601taatctacag ttacagagag ggggtgagta caaagaggca ctaaggaact tttggggata
|
210661ataataatat tctattgtgg ttacatgggt atacacattt gttaaaattc atagaactat
|
210721ataYtttgaa tgagtacatt ttattgaatg taaattatac catagtttta aaagaacttt
|
210781ttaaaagtca agatgcaaac tggggaaaat atttgccaca tgtatgacaa attaatattc
|
210841ttaatataca aaatgtcatg caaattgata taaaaagcat taagacctca acaggcaaat
|
210901ggccaaaaga cacagaaaag ccacaaaaga ggaaataaga atatctaata aacaggttaa
|
210961aattaaagca atgaaatact gtatttcaca aaccaaatga gcaaatttca cctatcaaat
|
211021gagttttttt gtttttgttt tttgctttga tgataatttt tgttttgttt ttactttaat
|
211081gataatacta gtattgtagg acaagatgag cactcttctg gtaaaaatat aaattgatac
|
211141atttctagaa cacaatttgg aacactatta tataagcttt agcaggaaca ttaaagttaa
|
211201gacccaaaac cttaacaatt ttcagattat ttgacccact tctagaaacc tgtgctaagg
|
211261aataaacaaa gatgaatgat caaaattaga gatttacagg caagagtttt cagccaggca
|
211321ctgtggttca cacctataat cccagcactt tgggaggtca agctgggagg atcacttgag
|
211381gtcaggagtt cgagaccagc ctgggcaaca tgatgaaact ccatctctac aaaaaatttt
|
211441aataattagc ccaggcacag tggctcactc ctgtaatccc agcactttgg gaggctgagg
|
211501caggcagatg acttgagacc aggagttcaa gaccagMctg gacaacatga Kgaaacccca
|
211561tctctaccaa aaatacaaaa attagccgag tgtggtggca catatgtttg taatcccagc
|
211621tgcttgggag gctgaggcat gaaaatcgct tgaacctgRg acgcagaggt tgcagtgagc
|
211681tgtgatcacg ccactgtact ccagcctggg caacagagtg aaactctatc tcaaaaaaaa
|
211741aaaaaaaaaa ttagcgKgcg tggtggcatg cacactactt gggaggctga ggtgggaggc
|
211801agagcctggg aggcagagtc Wgcagtgagc tgaggtcaca ctactgcact ccagcttggg
|
211861caacagagta ggactgtgtc tcaaaacaag aaaaaacaag tctggccatg gcggctcagt
|
211921cctaiaatcc cagcacttaa caaggtagag gcaggaggat agcttaagcc caggagtcca
|
211981agacctgcct gggcaacata gcaagacccc attctccacc aacaaaaggg acaaaaaaga
|
212041atttttatta ctgaccttgt ttctagcaag aaacaatcta ggataagcca ctaggttgag
|
212101taaacgctgg catcaatatg atgaactatc gaatattgtc catggtacaa acttaataaa
|
212161tatttctcaa atatactcaa cgtatacact atataagaac cttagaaagg agtgagatgt
|
212221gtagatgact tacacNNatg ggtagagaaa cacataaaca aattgtttca ttgcagcaaa
|
212281tattggaaat catctaaatg ttcatcaaga gaggtgaaat taggccgagt gtacttgctc
|
212341atgcctgtaa tcccagagct ttgggagacc aaggcaggag gactgcttga ggccaggagt
|
212401tcaagactag actgagtaac atggcgagag ctcatctcca cNaaNttttt ttttNaatta
|
212461gccaggcact gtcgtgtgta cctgtagtcc tagctactca gaaggctaaa gtcagaggat
|
212521cacttgagcc caggagttca aggctgcagt aagctatgac acgccactgc actccagcct
|
212581gggtgacaga gtgagatctt gtattgaaaa aaagaggtga aattaaataa atcatggtat
|
212641gtccacacaa tgaaatgcta tgcatctgtt aaaaacaggc cagatctaat ctatgtccta
|
212701ggctgggcgc agtggcttgt aatcccagcR ctttgggagg ccaagRtggg tggatcacct
|
212761gagatcagga gttcaagatc agcctggcca acatggtgaa accccatctc tactaaaaaa
|
212821tacaaaaaaa ttagcYgggc gtggtagcac atgcctgtaa tcccagctac tcgggaggct
|
212881gaggtRggag gatcacttga acctggaagc cagtggaggt tgtggtgagc caagattgct
|
212941ccactgcatt ccagcctggg caacaagagt gaaactccat ctcaaaaaaa taaaataaaa
|
213001taatctatgt cctagattgt taaaaaaWWt ttaaaggtgc agaacagggc acttggaatg
|
213061ctactatttg aagggagaaa aaaataaaag gacaSataaa tatttatgtt tatataacat
|
213121caccagaaag atacagaaga aaaaacaaaa caggtaagtc tatactgaaa gactagggtc
|
213181tgaggatgtg aaaacagggg tgacagagac ttagatttac tttttgctct caattacttt
|
213241ctgtagtgtt taaatttttt accatataca ggtttttctt tttcaaaaaa acaccaccaa
|
213301aaacaaaaac acagattttt ttttagaagg aaggggagtg ttatggattg agtttcttag
|
213361aaggaaggag agtattatga gttgagtttt ttagaaggaa agagagtgtt atacgttgca
|
213421ttatatcccc tttatatgtt gaagtcctaa cccccctaca ggttgaacat cccaaattca
|
213481caaatctgaa atgcaaaatc ctccaaaatc caaaactttt tgagcatcaa catgactcat
|
213541gaagatctca cccaatttcc cagaagccct cgctcccatc ggactagaat cttcttttga
|
213601gaggcctttc cttttctcat ccctattgca accagtacaa aaagcaaaac agaaagacac
|
213661taaagcaaaa ccaaagtttt agtcacaaaa accaaatggg ttggcgaggg aaggtggtgg
|
213721ttacagggaa ggttttaagc tcaccaggcc ctgtagctga ggtttcaaaa tggcagctag
|
213781ctggacgcca tctggtctaa atctgctcac ccaaacctcc ctccagttct ccaagggatg
|
213841tccctaatta ctagcacagc cagctgccaa catggaatct aggtctccct tctttcaaat
|
213901attagagatg tgagaccaga aagattactt cccaatacca gagaaaaggc tacgagggag
|
213961gaacaaggga gagaaggaga ccttcactgc agcatgcaag gacatggcgg acgcgtccca
|
214021tcccatatct cagctattat gcattcccaa ctggcttggc caacatccag agagactcca
|
214081ggctggtgag tctgtgaatg tgaagtagag ataagcaagg cggcgagggg gagctcgccc
|
214141actgttatat acgggctgca gcattgcgtg gcgaggagtc aggggaatct tccatttcca
|
214201agacatttct gcactcgatc ctgctcccca agactaagaa ttctttMttg gcttcctccc
|
214261actccctgga atgtaactaa gcagttacct tgagaacaag gaaaaattgg gggctaggga
|
214321ggtgtatgag tgttttaatg tgttaaaaat cacatttacc ctggatactt gtttgcaata
|
214381aaacagagag taggaaactc cattcttacc ttcatctatg ggacaggcac ccagtggcaa
|
214441tcattgtgag aaatagggag aggctgatct atgcttaggg agctcagaaa atgctatgct
|
214501tccttccagc tgtagggaag ctgagccact ggggaagagt ggatgcattt ggacaaacag
|
214561gaatggatgg aaggctttct aggagagggg accacatgag caaagcctga agaaggggtg
|
214621gttcttatct agcaatgagg aagtgtgagg agaggcaaag aaatatcttc tagaagctga
|
214681gggatcaggc actggaagct tatctacctt ctccaactcc agggtaccac caaggagagc
|
214741aaaatccaga aacaaggggc acctgcaaag tggtggagga aagaggagga aaggaatgtc
|
214801tgccccRagc ccagccccag ggtcagatgc cgggaaaaat tcctgggatt atttggtgct
|
214861gtatgagatg gatctggagc caccctggct ccaagaggga tgtgggtttg gactggggct
|
214921Kccaggactg gtctggggca agctaaggac actttcacgt gtccacactt ttgtacttgc
|
214981tgttcaccag tatctccttt ccccccftct cctccctgtt catggaaatc cttaaaaatc
|
215041atctcctctg ggaagttctc ctgatgctct cattcagaat taacccacca ttctttatgt
|
215101cgcttcaaca agttgcttgt atctcttttt ccatttacgt tttctttttc tttttttttt
|
215161ttNgtttgtt tgtttgtttg ttttgagaca gagtctcact ctatcgccca ggctggagtg
|
215221taatagcgcc atcttggctc actgcaacct ctgcctcccg ggttcagttc aagccctgct
|
215281cctcctcagt ctcccaagtg gctgggatta caggcacctg ccatcacccc tggctaattt
|
215341ttgtattttt agtagagatg gggtttcacc atgttggcca ggctggtctc gaactcccga
|
215401gctcaRgtga tccgcctact tcagcctccc aaagtgctgg gattacaggc gtgagctacc
|
215461acgaccagcc tacgctttcc tatatgcctt tttttttatt ttttgagatg gagtctcact
|
215521ctgttgccca ggttggagtg cagtggctca atcttggctc actgaaacct ccacctcccg
|
215581gattcaagcg attctcttgc ctcaacctcc caagtagctg agactacagg cgcatgccac
|
215641catgcccaac taatttttgt atttttagta aagatggggt ttcaccatgt cggccaggct
|
215701ggtcttgaag tcctgacctt aggtgatcca cctgtctcag cctcccaaag ttctgggatt
|
215761acaggcatgg gccaccgtgc ccagcctatg ccttgtctta taattagtct ccctctcttc
|
215821taaatgtaaa ctctcagatg tcaagaacta gatcttatac atctttctga ccccatcccc
|
215881cagcaccagc tcttccccag agcagacact cagtaaatac ttattgaatt gaatatacag
|
215941acccacaagg agcaacctgg tactggcgga catttttgat tcctgcatcc attcattcat
|
216001ttgctcaaca accatgtgag tgcctaatac ctgccaacct ggctcacact ctctcacaga
|
216061gcacactcRa attgtttcat caaccagcta aaagtaagtt cagtatcaat tcagggcttc
|
216121ttttcagttc tagaacatag aaaatttcac aggatcacct gaacaccgca gggcgggtgc
|
216181agcctacatc ccattgcctg tttctgtcca gatggaaagt cacaccctca agaaggcccc
|
216241tggggaagac agattgtctg ggatgtggat gagggccccc acaggctctg cccagcccag
|
216301cccagcccag cccagcccag cccacccagg ggaaccctag atacacctat cacaggagat
|
216361ggcagttaag ataactctat ctacatacac agtaccctgt ggatactaag taaggagctg
|
216421gtcatttgga atgaggcagg agagctctag gaagtcctct ctgcagagta gatgtggcca
|
216481tggaggtggg aggattaact gaaggtcata agaaaagtct gcccttctca gagatcaata
|
216541agtgcaaatt acttgagagt ccaggaactg ctctgccatg gaggaaaaat acagatgggg
|
216601gcaggggcgg gaaaggaagg gggcaggtta gggacagtca ttgatctcgg cgggctcttc
|
216661caagtctaaa attgtaggat tctaacctga acctcccctg ccaacaactt gaaagagttg
|
216721tcttgagatc agggacatgt ggagagaaag ttgaatagca tgtcagataa taaaccaaga
|
216781agaaattgtg aagtcaaaac aagggataaa ttttccttat ctctctaaga catgcatcaa
|
216841agcagctgRc tgctgtctgc ctggcctggg aagatgataa tggtttttaa tggcccgtaa
|
216901acaataggac cagcctttgt aataaagttt aaccaattaa tcctctaggc ttcctccctg
|
216961cactctgcct actctccgct cctcctttct gtgatggggc aaccttcagg ggtctgaaaa
|
217021gcaagggatc cagcccctag acgcaaacct ataggtgaca ataagagttg cccagaggaa
|
217081gtgctaaaga aaattgcctc tatcctgatc tggctaaaag gaggaagaaK ccctcttttc
|
217141agSgaaaagg agaggagaga tgatgcatca aggaatttgc acaagaggta aacttcattc
|
217201ttattcagga gctcattcat tcattcagca aacattcatg aacacctact atgtgcaagg
|
217261catctgcaga gggtgcaaaa atatacaaag aaaatacctg cccaagatgg aattaaagcc
|
217321tggagggggt ggtactggga acaagacaca ttcacagatg gccgggcgcg gtggctcacg
|
217381cctgtagttc cagcactttg ggaggcagac gtgggtggat cacgaagtca tgagatcaag
|
217441accatcctgg caaagatggt gaaaccccgt ctctattaaa aatacaaaaa attagctggg
|
217501catggtggcg cgtgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatcgcttg
|
217561aaactggaag gtggaggttg cagtgagcca agattgtgcc actgcactcc agcctgggca
|
217621acaagagcga aactccatct caaaaaaaaa aaaaaaNgac acattcacag atatcaatcg
|
217681taaaagttag tacaatagcc tctgcaaacc actgtataag tccaNcttct ttttccattt
|
217741cttctttcat gtgccatgtt ccgcttgggg tggttacgac agacaatatt cagaaaatgg
|
217801aagaatcaga aagagaagaa agtggaacac acaagagaaa gaaaaccaag gccctcctcc
|
217861ctcctgccat ggccctctct gtcttcagcc ctagttctgg aaaagaaaag ggtgtgttgt
|
217921cactagaggc ctccaggcag gtccatgcca ctgagtcaca tttcaagctg tgtttgcttc
|
217981ctacaccaac aaggcatatc ttttctgaat tgtgcaatat tctggccacc tgggtttttc
|
218041tacttggtat accaactcct agtactcaac aaccattccc tttactcttt tttttttttt
|
218101tttttttttt tttttgagac agagtctcac tctgcacaat ctcggctcac tgcaacctcc
|
218161gcctcccaag ttcaagcgat tctccctgtc tcagcctccc aagtagctgg gactacaggt
|
218221gcccaccgcc atgcccagct aatttctttt ttacttttag tagagacagg gcttctccat
|
218281gttggccagg ctggtctcaa actcctgacc tcaggtgatc tgcctgcctc agcctcccaa
|
218341agtgctggga ttacaggtgt gagccactgc gcctggcccc cctttactct taaatacagt
|
218401gtgtgccagc tgtagtagtt tatgcctgta ctccRagcat ctcaggaggc tgaggcagga
|
218461ggatcacttg agcccaagag ctttaggctg tagtaagcca aggtcacacc actgcattct
|
218521agcctgggca acagagcaag accctgactc ttaaaaaaaa atacaatgtg taatggtgat
|
218581ataataattc aaaggttaat catctctact tttgaaaaca ataatgaata ccttgctttg
|
218641catttgttta gcctcacatt tttttcagag ttcttcaaaa aatattatct catgttcatg
|
218701ctacaagcaa ccttggRtgg taacaaaggt taaacatcat tatttccact ttaaattttc
|
218761cctcctttct ccatttgttt tctactcaac aaacagtggt tgagtacctg cYatgtgcta
|
218821agcacYatgc tgggtacagg gtcatgcaac atagcagaaa aacagcagat cMtgccttca
|
218881acaggttcaY agagctatgg ggaggagaag tgaggacgtg gtccctgtct ccagggtctg
|
218941gggSatcttc tagaggagaa gattgagaca agcattaaaa gattatcatg ggccaggtgt
|
219001ggtgctcaca cctataatct caacactttg ggaggccaag gcaagaggat cgcttgagcc
|
219061tgggaggtgg aggctgcagt gagccatgat ggtgccactg cactgcagcc tgggcaacaa
|
219121agtgagacca tgtcttaaaa aaaaaaaaaa acttaatatg attttaccag gtagaaaaga
|
219181gaggaaaggg gattccagag agtgggccag caatctatgc acagagaaRa gtgagccatc
|
219241tggggcatcc agaccatggg gtgaggagca atgaagggca aaggctgaga aagactgaaR
|
219301agggaggctg ggcccaaaca acggagccaa gagtgccttg ccaaggagtt tggactttat
|
219361cctgggggca atgaggaaat cactgaaggt tttaagcaga ggtgggtgac gtgatcagat
|
219421ttgtgtttca gcaagattac cctggccacg ggatggagaa agcactggac tgggaagaga
|
219481ctgggcagac tctagaaaca ttcccaaaat agaattcgca ggactgggtg tcccactgga
|
219541gataggagga aaaggagata atagaaacag ccttctcact tgggcttgag gggccctcgt
|
219601ccaatatagg agaccagtaa gaaagccttg cccaaggtca cctcaagtta cttgatggct
|
219661aactcgaatc aagaagctca agttccttct ggtagaaacc tcttagtctg cctcattcac
|
219721attgatcagc aaataaattt aaccatcatc tgccagRctt tccttgtttt ccactttata
|
219781catgtgcact ttttgtccta tggagattat taagatcatt agggcaaaat tccttttgac
|
219841ctcccataag gcctctcaca gtacaagaca atatgtggtc aataaatatt tgttattaaa
|
219901tcaaactcca ggagccccaa gaacccatca ccaggcattg ccttacttac aacatgagat
|
219961atttgccttc tttaatccct aataaacagt tttttgtttt tgagacagag tcttgctctg
|
220021ttgcccaggc tggagtgcag tggcacggtc tcggctcact gcaacctctg cctcccaggt
|
220081tcaagtgatt ctcctgcctc agcctcccaa gtagctggga ttacaggtgc ccaccaccac
|
220141gcccagctaa ttttttgtat ttttagtaga gacagggttt caccatgttg gccaagctgg
|
220201tctcaaactc ctgaccttgt gatctgcctg cctcagcctc ccaaagtgct gggattacag
|
220261acgtgagcca ctgcatctgg ccaacagtat tttttattta attcctagat aaagtaattc
|
220321ctagatgctt gaatttcaca atccaagata attttttttt gagacagagt ctcgctctgt
|
220381cacccaggct ggagtgcagt ggcgtgatct ctgctcattg caacctcacc tcccaggttc
|
220441aagtgattct cctgcctcag cctcccaagt agctgggatt acaggcgcct gctaccacac
|
220501ccagctaact tttttgtatt ttttagtaga gaYggggttt caccatgttg accaggctgg
|
220561tttcaaactc ctgatctcaa gtgatccgcc cacctcggct tcccaaagtg ttaggattac
|
220621aggcgtgagc caccatgccc agccacagtc caagatattt ctaacaacaa caacaaaatt
|
220681ggagcgttca atgtggtctt gccaactttt gttttaacac cattgtttct taaaagaaag
|
220741aacattgaat acatatcccc aaagtcagga taatataatt ttaagatgaa ttttccaaat
|
220801taaatcagag ttcctcaacc tcagaccaat taacactgga ctgaagaatt ctttgctatg
|
220861gcagtggagg ggaaggagaa gggggagctg tgggcaaaat tgcaccagtt cagaaccact
|
220921gaatttttta aagtacgctt tcttaaaaat ccagttacac tgtccttata ttttggatca
|
220981gtgaaaacta tcacagactg ccaccagtcc ataaacagct tttgggaaca agagactcag
|
221041aggtgaagaa tgtggaattt gaaatcagac ttgaactcaa atcccagttc cacctctcct
|
221101cattccctga ccttgagcaa ggcactgttc caagcctccc tttcctcccc tgcacagcga
|
221161ggacaatacc accccatccc agttgtgggg aggattcaat ggaatagatg tgacgcactt
|
221221agcatgtgac catcgggaac ggaagtatga cattattaac attatttcta ccacttctat
|
221281aacatatgtg gtatctaata caaattaatg actgctaccc aaatttcaga ctttctgggt
|
221341caaaaggacc ttacacataa tatagtggac tttcaataaa cacttaccaa atggacaaat
|
221401gaaccccttg tcaccccgat ctcactagtt ccttccctga aacccgacac atctgagtcc
|
221461ttttctcctt tactaaccct ttctccaatc ctgctcatgg gaattaaagc tgtaaaataa
|
221521gcctggcgca cctYgggcct ctgccctggg ctctgtgggt gggagcactg tggaagccgt
|
221581atcaatcgcc cccacctatg agagcctttc ttcagggcca gccatgaacg tYccccatgt
|
221641catcagcatc ttcaggctac tgctgtcctt cttggatatt taacctggag gcgggccagg
|
221701gacagaaaaa ggaggtggca agatccttga acaaaaggag ctataaaagg gcgttggggg
|
221761aagcaaggca aacggcagat taaacaagca ggcacctcaa ggaaacgtga cgcgggaggg
|
221821gattccgagc ctctctgtct gcttacttga cagcaagcag gtcagagttc ctgccatttc
|
221881cttctagtag aaaccccacc aagaccacct ccccgccttg gcaggcaaag cactggtagc
|
221941tctcccaagg gaaaaaaaaa acaaaaaaca cacactcctt gttacaaacc agacacagtc
|
222001ctggacagag cccagctaac aataaatttc tggggttcat ctcacaagta cattaagtat
|
222061cttctgacaa tctcccaaag ggctgggttt ttctggccat cacagggctg tagaatattg
|
222121agtacaagga gagggcttca agaacagggg atccaagccc tcgtttcatt gatggggaaa
|
222181ctgaggctca gagaggggga aggaacttgt tcaggatcat ccaagtatgc tccYgtcagt
|
222241Rgcagcactg agccaagaac tcaaggcttc agttttggca ctgggttttg ccagaggctt
|
222301gaaaacatac caagaagtgg aaggtgtact atgagctaaa tctcactttt cctgaaaata
|
222361tagatgtgtg ctcacacagg cacacatgtg cataaaaggt agggaaagag gaaaacaaat
|
222421gtagcaaaat gctagtaaat ggtgaatcta agcaaagRgg atattggtgt tcattgctct
|
222481attttcacaa cttttcagaa ggcttgccat ttttccaaga aaaatctgag gaagggctag
|
222541gtgtggtggc tcatgcctgt aatcccagca ctttgggaag ccaaggtggg aggatcgctt
|
222601gaggtcaaga atttgagacc agcctgggca acataacaag accccatctc aacaaaaaaa
|
222661ttaaaaattg ccaggcatgg tggctcacac ctgtagtccc agctactcag taggctgaag
|
222721caggaggatc gcttKagccc aggagttcRa ggctgcaatg agctatgatt gcactactgc
|
222781actctagcct gggcaacaga gtaagaccat gtttctttaa aaaaaattaa aattaaaaaa
|
222841taaaaaattt tgagggagaa agataaagca ctaactagca atctaagata aaaaattttt
|
222901ttaaaaaaat cacttggaaa agagtaggaa ttcctccttc aatttcattc agtttcccta
|
222961gctagggact aatatcctta gaaaaagtta taagaaatcc agaggttaaa ggggtgggac
|
223021tccaaacaag taagagatcg ccagtattca tagcagtccg cagctacagc aatcttagaa
|
223081tccaaatacg atttcagata ttttgtccca tcagctccta aaatacatat attctggtca
|
223141caccatgtat cctctgttgt ttttggtgca aaaagtaaag taaccaYgaa ctacagatag
|
223201ggcaaatgtc agaatttttc caggggactt tatcaccttt gcaatacagg tagtttataa
|
223261atgcaataca atatagttta atttctattc aatttgcaaa ttctttcaca tgagtaaatc
|
223321atttaatcaa aatccacatc caacccacac tcaccatgtt ctctatccat attagtattt
|
223381ggtttgggcc atactgggtc cataatccag ccctgaaaat ctatcctggg ccacatatat
|
223441aactcatacc aatagcaggg cactcaaggc atgaagattt gagggaacac aacctatcca
|
223501agaaacctca aggaattcct tatggctgaa gtaaggtctg aggaaaccat gagcagggga
|
223561atatgacttg gagagaaggt agaggttaaa tccaggaggg ctcatacacc caacaaagga
|
223621gttggaagtt tatccttcag aaaacaagga gtcactgaag ggttttaagt aggcagtgat
|
223681ataattggat cattctggca gagtacagat ggatgaaagt aactcaaagc taggaagact
|
223741atcggaatga caaagacctg aactaaggca gtctgagcgg gagtgaactg ataacacatt
|
223801aggaagagct attgaccaca gcaaatggac aaaactgggt gggaagaggg cagatgtgtc
|
223861tgagagagac agaaaggatc ccagatgacg tctagcttgg ccaactaggt agacgatgac
|
223921aacactcacc ctgacgggga atccgggagg aggcgaaggc ttggcagagg aacgtggtga
|
223981gttttgaacg tgttgaggtc ctggttggat atacaaatat ggagctccag aaagaagccc
|
224041aggatgaata tgtgcattgg gagtaaccaa cattaatgta cggggatgga tgccaagggt
|
224101gcagaggagg tcagccagag aattgggggc aaaacaagaa ctgagtcaag gacagaaact
|
224161ctgggggaaa aaaaaaattt aagggcagtc agggaagaag agaccccaaa aaacgttgag
|
224221gagtagccaa agaggtaaag acctaggcct gcttttaagt gacccactaa actcctccat
|
224281ctccacaggc tggtcacacc atgctggggc tggggaagga ataatcatgt gttaaaataa
|
224341actcatttct caatgaaaag acaaacagcc caatttaaaa atgggcaaat aacaaataga
|
224401catttctcca cagaaaacat acaaatggcc aatagacaca tgaaaacata ggaagtatca
|
224461ttcggtcatt agggaaatgc aaatcaaaac cacaatgagg ccgggcatgg aagctcacgc
|
224521ctgtaatccc agcactttgg gaggtcgagg caggtggatc acttgaggcc aggagttcga
|
224581aaccagcctg gctaacatgg tgaaactcct tctctactaa aaatacaaaa attagccagg
|
224641tgtgctggtg cacgcctgta atcccagctg ctcaagaggc tgaggcacga gaattgaacc
|
224701tgggaggaga aggttgccgt gagccgagac tgcgccattg cactccagcc cgagtgacag
|
224761agtgagactc tgtctcaaaa caaacaaaca aataaacaaa aaacccacaa tgaggccagg
|
224821catggagtct gacgcctgta acgccaacac tttgggaggc caaggcgggt ggattacttg
|
224881aggtcaggag tttgagacca gcctggccaa tatggtgaaa tcccatctct actaaaaata
|
224941caaaaattag ctgggcatgg tggcaggcat ctgtaatccc agctattcgg gaggctgagg
|
225001caagagaatc acttgaaccg gggaggcaga ggttgcagtg agccgagatc gtgccactgt
|
225061actccagcct gggtaacaga gtgagactgt ctcaaaaaaa aaaaaaaaaa aaaaatcaga
|
225121taccacttca cacctggtgg gatggctaga gtcacaaaga ggtagaggaa ctggaccccc
|
225181catacatcac tgattggaac acaaaatgcc acagtcactg tggaaaacag cttggcagtt
|
225241cctcaaaact tcaaacacag agttattata tgacccagaa actcctcccc taggtatata
|
225301cccaaaagaa ttgaaagcat atgtccacgc caagacttgt acatgaaagt ttgtgttagc
|
225361attcttcata acagccaaaa agcagagata aagcaaatgt ccatcaacag atgaataggt
|
225421aaatcaaatg tggcgtattc atacaaggga ctattattca gccataaaaa ggaagggagt
|
225481actgaaacat gcaacaacat ggctgaacgc tgaaaacatt atgctgagtg acagaagcca
|
225541gatacaaagg ccacatgtgt tatatgattt catctctatg gaatatctag aatagggaaa
|
225601tccaaggaga caaaaagcag attagtggtt accaggggta gaggggacag gggagtgggg
|
225661agtgtctgct tcctgagtgc agaatttctt ttttcttttt ctgtcaccca ggctggagtg
|
225721cagtggtata gtctaggctc actgcaacca ccgcctcccg ggttcaagca attctcctgc
|
225781ctcagcgtcc tgagtagctg ggattacagg tgcacgccac catgccccgc taatgtttgt
|
225841atttttagta gagacgggat ttcaccgtgt tggccaggct ggtctcaaac ccctgacctc
|
225901gtgatcctcc ctcctcggcc tcccaaagtg ctggaattac aggcatgagg ccaccatgcc
|
225961aggccaggat ttctttgtag ggtgatgaaa atgttccggc atcagatgtg gatgatggcg
|
226021gatgtactaa ccaccactga attacgcact ttcaaatggt tagaatggtg aattttatgt
|
226081tgtgtgaatt ttctctcaac agaaaaattc aatcatcctt tacaaagtga cccacagcca
|
226141caaggagctg gggaagcagt ttctccagct tgcagcagga gctccagata ttctgagtaa
|
226201agaagccaaa cagcctgctt cccgggagac ccttaaatgt cttcacacat ccacagctgg
|
226261gggaggagac gctgatgaac aggagaagat ggagcatcgg cctcccctgg ctactcactc
|
226321tgtgctcggg ccgcctcgcc cacttgtaaa accccaaatg ccagggtggc agcaaggcat
|
226381acatgcaact atgacttgac ccgcagcgag gcagcaacca ggtctcacct gggcatagtt
|
226441accccacaag gacaggaaag gagaaatggt ttccaggccc aggacaccca gaagccacca
|
226501aaaaccaacc tcatggttca tcccccttat ttgactcttc gacacctaaa acctgtgcgt
|
226561tgtgttcaag atacacccgc cggagaccac attcccagac atcccgaggg ccagccgtca
|
226621ccacaSgggt gcctcgggga gatgctggag acacaagtgg ctttgaaatt agcacaactt
|
226681acatggcctc caggtctgct gtggaaatcc aggtccaaag aagaagccag tgaggaacag
|
226741gaggctgatc attgtgttct cagaaggggt tggagcctct ggggaggggg cactgaggac
|
226801agagcacggt gttctgcaga tcatatcaca tctctacttc cctctccagt gatatgcttc
|
226861cctcRctctc ccattttgct ccctctctcc tgccaaactc ccagggcaac cctggataat
|
226921aaagtgaccg aatgtgaatg cttccaggtg gcacaccagc actccagaga aactgtcaga
|
226981gcagggggca aacccctggc ctactccagc cactggataa gcgcaccctc ctccatgcct
|
227041ccctgctcct gcctgccctg aagggagaag gagcgcaatg aaactaggtc ttcccttggg
|
227101gttctgacca cctcgtgggg agattatgat tgccctgtgg ttgccatgcc tactgtgatg
|
227161tcactccttt tatcagtcta tctggatgaa tttttccccc ttttctctga aggaaacctc
|
227221ctacccagtg cttaggagcc cattgggagc tcccgccctt gtcttatctc gatctgggac
|
227281ctcagaagac tccacattcc taacaggact agctctcagg atgaagaaaa tctctctcaa
|
227341gctggtcaat ctactcctag atttaagcag aaccaaacag aacctatttc aacatcccct
|
227401ctcagaatgc aaacaggaga cggctgtgtg gaaagatcca atcaccttta cttaattggt
|
227461cagaataaaa tcactttttt ctttttaagg cagagtttcc ttctgtggcc cacactggag
|
227521tgcactggcg caatctcagc tcactgcMac ctccacctcc caggttcaag caattctcct
|
227581gcctcagcct cctgagtagc tggaattaca ggcgcgcacc accacacctg gctaattttt
|
227641gtgtttttta gtagagacag ggtttcacca tgttggccag actggtctcR aattcctgac
|
227701ctcaagtgat ccacccgtct cggccaccca aagtgctggg attacaggca tgaaccacca
|
227761cacctggcca gaatcacttt ttcagtaaaa taagtgcaaa gaagaatgag ggtgKgggaa
|
227821aggtttactg atcccacact ttgtcatgca cagaggaagg caaagaaaga aagaaaactc
|
227881tttcctaaat gatcacttgt ctccagcagg tgtatcttga ccattccagc catggatcta
|
227941tagggagttt catgccaatg aaaagcattt ttttggggtc ctactatgca tcaggcactg
|
228001tggcaggtac tggagactta gtcccagccc ttaaagaact aataatagga tcatggccag
|
228061gcgtggtggc tcacgcctgt aatcccagca ctttgggaag ccgaggcggg tggatcatca
|
228121gaggtcagga gttcgagacc agcctggcca acatggtgaa accccatctc tactaaaaat
|
228181acaaaaatta gctgggcgca gtggcagtca cctgtaatcc cagctacttg ggaggctgag
|
228241gcagaagaat cgcttgaacc tgggaggcag aggttgcagt gagccaagat tgtgccattg
|
228301cactccagcc tgggagacag agcaagactc catctcgaaa aaataaaaaa agaaaagaaa
|
228361gaaaaaaaag atcactgttc acaatcacaa catttacaca gcctccttca aaagaatttc
|
228421ttctctagaa agataagctg agagaccaga cagttYgtct gcggccttca tgaagtgaaa
|
228481ggaggcagag aagaaaggag ttggccatgg acaggttttg ccccagatcc ttgagtgaag
|
228541accccagcct gctgcaagct ttttcctcat tctgtcctcc cctcctggaa tctgtggcag
|
228601cttccacagg cggtgaaaga aggcagcaag cagtggctcc agtgccagct gcagcaacca
|
228661caccagggga atggggccat ctgacacaga gagggtgtga gggccaggga gactgtccct
|
228721gtagccagct aacccctcca gtcaagtcga ctttcacaaa atgggcctgc tcctggaagt
|
228781cattgatgcc attgttaaaa cacagcacca ggccgggcac ggtggctcac gcctgtaatt
|
228841ccagcactct gggaggccga gacgggcaga tcacttgagg tcaggagttc gagaccagcc
|
228901tggccaacat ggtgaaactt tgtctctact aaaaatacaa aaattagctg ggcgtggtgg
|
228961tgcacacctg taatctcagc tgttcagaag gctgaggcag gagaatcact taaacccagg
|
229021aggcRgaggt tgccatgagt cgagatcgag ccactgcact cctgcctggg caacagagtg
|
229081agacYctgtc tccaaaaaac agcaccctgg agaagacagc agtccattca cactggaaac
|
229141atccagactt attacataaa aatggcaatt agtggccagg cacagtaact cacgcctgta
|
229201atcccagcac tttgggaggc cgaggtggcg gtgtaatccc agctactcgg gaggctgagg
|
229261caggagaatc gcttgaaccc aggaggtgaa ggttgcagtg agctgaaatc acaccactgc
|
229321acttcatcct ggatgacaga acgagactcc gtctcaaaaa aaaaaaaggc aattactgtt
|
229381ggcatcagca gcacagttgt tttcagccaa aacttaagac acagaactag ccttatcttt
|
229441ccagtatatg gtatgtctct tgctattttt tgcaaattat ctatcatata tattatcata
|
229501tatattcttt tttttttttt tttttttttt ttttttttgg agacagaatc tcgctgttgc
|
229561ccaggctgga gttcagtggc atgatctcgg ctcactgcaa actctgcctc ccgggctcaa
|
229621gcaatttttg cacctcagtc ccctgagtag ctgggattac aggagcacgc caccacaccc
|
229681agctaatttt tgtattttta gtagagacgg ggcttcgcca tgttggccag gctggtctca
|
229741aactcttggc ctcaagtgat ccatctgcct cagcctccca aagagctggg attacaggtg
|
229801tgagccaccg catctggcca tatatattct tttaatggca agcgggaaca aaatcgtatt
|
229861cccattttct gaatgagaaa accaagccta aaagagggac tcccaagtaa tatcaacttg
|
229921caaacctatg aatttttatc ttaaatactg gctttgaggg acctttggca acagcaaagg
|
229981cattcggcaa tttgtgtgga agtcacatta ccagcccacc gaataagcca caactatgag
|
230041ttcttccgtg attagcgggg ctggggatgt ggcaggcagg cgtggaagtg agatccacgt
|
230101gaaagaccta agcactgact ccccgaggga ctggcgaaat gacgcagggg ccagatagat
|
230161gtcagatttg gccaaagtgt cctcctttct cacaagcccg tctgcctttc acctgtcctg
|
230221aggtaggaca accggatgcc ctactttgct gtgcagcccc actctcttgg ggacagtagc
|
230281ccaaacaggc tgctcttgct acacacagat aagaagcttt gccacccaaa accaagaaag
|
230341gggccggtga ggacacacag ggaatgctca ctcagtggtg gctgagtttg tggaagtagc
|
230401aaaacctgca ctgtaggacc cacacctgtg agagagggcc ccacgggaat ctcagcttgg
|
230461atcaaagcag gcgggtgctc actccactga gggcagcaga gcccagctcc aggtgcgatc
|
230521aggaagtgac ctgagaagct ggagttctgg actcacagac ccaggcttga atttcagcac
|
230581cactcagtca ctgtgtggtc ttgagtgact tgcccttgtt tttcctcatc cataaaatag
|
230641ggataaaaat acctgacctt gaaaaattat acgaatgcca gcacacagta catacgcaca
|
230701gcagagacag gagctagaat tattgatttg ccaaatgcag cagtgtctgg actcagccgc
|
230761ccacttctga ccaatggcct tcacttgtaa cacagctgat ctggagggta aagcctgcag
|
230821ccgtggaacc aagctctcgc caaggtaact gacccatgtg gggctcagag ccttgttctt
|
230881actagaacca ctctagtttg tttgattttt tttatttatt tatacacata attctgtgca
|
230941ttcctttatg catatgtata catatatatg catatgtata atttattcaa atagcatcat
|
231001atcactgata ctattctcct acgccctacc ctcccacatg gctactcaca gcccctgcct
|
231061ttccaggcgg cccgtgttaa catcttagtt tgtatccttc cacaattctc cccatattca
|
231121tgtaatttta cacacacaca cactgaatag tgaagttttg gacagtgtgg gggcgttatt
|
231181gtttaacaaa aatggaatta tacatcatac acagtctctc cctctttttt tattctacca
|
231241taatttgcca aaatcctttt aatggttctg ttataattca tgatataaag gtgtcaaagc
|
231301tattcagcca ttcctctact gatgggaatt cactcagttt caacttttgg ccactaccaa
|
231361caaaaaagca ataaattcct tgacagtatg tcctaaccaa agaccatttt ccaaccagac
|
231421aaaaggccag gtcccaggat gtgagggtca cccatgaaaa ggacctcatg atgaactcct
|
231481gattcagcca catcatcctt aaaattctcc ttagaagaga gaccctctgc tcctagaaat
|
231541acaaattccc aggcatgggt ctggcttcca aactctagct cctccagttc ttactgcatc
|
231601aagtcaattc tgcaggtctt cattttccca tctgtaaaat aaaatcataa ctgccttagg
|
231661cggcaggatt tgagagtgct ttagcaaggg atttttatga gggagcagtg tgtgaaataa
|
231721tatttttgct gtaattctgt gagatgttgt ttctagNttg tNtgggggtc agggaaggga
|
231781gggcaaaaca gaactaacag attcaattaa gttccctctg agactcaagg tccctattta
|
231841taaggtacct ggggctggat gggaaggcac ttctatcttc tgcatttctg aaacacctgg
|
231901tactgtggtt gtttacaagg aaaacttagg aactggacag gggagctttg gagtgtctac
|
231961ttgcccagtt ttgtcagatt ccaaagaggg gcaactataa ttgaaattat aagaagaatg
|
232021gtccaatcag caaattttgg aaaatctgta atctcactgg tgtttgattt tcactcaaaa
|
232081attccctaag ctctacattt cattcagtaa aaagttgggg ttaggggaga gatggagaac
|
232141ttcttttgca ggggtatagt gatttatttg gtctattctt gaaaaaaaat gagaaatttt
|
232201gggaaaacaa tcttaaaatt tccatttcga gtagcagttc taaaagactt tcaagagcct
|
232261ctctgaaaag aagcagttac agcaacttga atgaatttac ctggttatca tatggctcac
|
232321atgcatgaga gtgggggaga agacacggta aaatcaacag agttcgtgtc atgatattct
|
232381gctttaaaac ccaaatcaag gccaggcaca gtggcttatg cctataatcc cagcactttg
|
232441ggaggccaag ataggatgac tgcttgaggc tgggagtttg agaccagcct ggaaaatatc
|
232501atgagactcc tctctctaca aaagaaattt ttttgtaatt agctgggtgt ggtggtacac
|
232561ctgtaatcct agctattcag gaggctgagg taggaggatc gcttgagccc aggaggtcaa
|
232621gcctgcaagg agctatgatt ataccactgc actccagcct ggatgacaga gtgagaccct
|
232681gtctctaaga aaaaaaaaaa aaaaacctca aaacctgact atagaaKaat tttcttcatc
|
232741aaaatcgaat caagcagata attggcaccc ctttggaaaa ggattcagca gcctctactg
|
232801aacatacgcc tgccccatga cccagtaact cccctgcaag gtgtatatac ttaaggtctc
|
232861caaaagacaa gtaccagcat gttcccagca ccactactca tggaagaccc agaccaaaaa
|
232921ctaccacatg ctcatcaaaa gtaaaatggg aaaaKaaatc atggtgaatt tacataacag
|
232981agcactatat agcgatgaga atgaatgatc tacaaccaca gccaacgctg ggtgaatctc
|
233041acaaacgcaa tgttaaaggg gaaatccagc tagtaaagtg aacgtgctag aagattccgt
|
233101tcgatggggt tagactcaga atagtcaccc ttggtgggat ggggtaggga gcgttggggt
|
233161gcctggaagg ggcacggcta ggcttctgtg atgtttcttc atctgggggt ttgtgacaca
|
233221agcatgctca acttgtgaat tttgggtggt gaacatatgt gcactttttg gtatgtatgt
|
233281tatacttcag tttttaaaac tKaagaaatt agccaatgaa caaaaataaa catgattgtg
|
233341agctgggcat ggtggctcac actggtaatc ccagcacttt gggaggccga ggcaggcgga
|
233401tcacgaggtc aggagtttaa gaccagcctg gccaacatgg cgaaaccctg tctctactaa
|
233461aaatataaaa aattagccag gcgtggtggc agacgcttgt tatcccagct actcaggagg
|
233521ctgaggcaag agaatcactt gaacccagga ggcagaggtt gcagtgagcc gagatcatac
|
233581cactgcactc caacccgggt gacagtgtga gactccatct caaaaaaaWa aataaataaa
|
233641taaacatgat taaggataaa gcaatccagY ggacaaggct cttggagcca tattttattt
|
233701gKcatgtatc attcYgggga gctctcctct gtcaatgcca agactagcta gtcgagtgtg
|
233761gagaaaaggc attctgtgag aacagatgaa agggaacaga gaaactggca ctttctttgg
|
233821aaaagagttg tttccaaaac ctagatgtgc agcctctacc ccaggtaatt agtccaacac
|
233881actatccatt acagctgagt ccgggtttgc ttcaaaagca tcgggggttt tttgggtttt
|
233941gcttccctta aaaaaaaact tgttttgaat gaggggaaaa aggcgtagtt aatttttata
|
234001cagaaatctg ttaaagagat ctgatcaatg gtgacaaaat ggaagccaga gatggaaaag
|
234061attcactgtg aggctctggc actgaaggcc aacttgggct tccattcagt tcaataataa
|
234121tatttatcat agctgctaac aatttttttc tcttttttga gatggagttt cactctggtt
|
234181gcccaggctg gagtgcaatg gcgtgacctc ggctcactgc aacctccacc tcccgagttc
|
234241aagtgattct ccggcctcag cctcctgagt agctgggatt acaggcatgt gccaccatgc
|
234301ccagctaatt ttttattttt agtagagatg gggtttctcc atgttggtca ggctggtctc
|
234361aaactcccaa cctcaggtga tccacccgcc tcagcctccc aaagtgctgg gattacaggc
|
234421gtgagccacc acacccagcc aatagctgct aagacttacg caggtttaca tatgctaggc
|
234481attgctctct gagcttatat atattaactc attccatctc tatctatgag gttgggattg
|
234541atataatccc cactttacac ccagagaggg taataacttg cccaaagtca cacagctaat
|
234601aagtgacaaa gctaggcagt ttggctagag tctgtgctct taacaattat accatattgt
|
234661ttcctagtaa gcatttctta tgcccgtact atgtgctggg caccatgctg gacaaaagga
|
234721gtactgagat atataaaaca cgggtacaca cataacaggt tctagtccat gcaatgatga
|
234781gaatcataca ggcattctga ggtctaattt cagaacaaaa cgttagaaaa ctgcctccac
|
234841acatctggac attaagacta aaatgcagtg cctgttttct cattggtatt attctattca
|
234901atagagtcaa ttttaagact aagcattcct tgacacccca cccatccttg ggtcatgaaa
|
234961ctcaataaag ctctcttcat tttgattgga ggggggaaaa ttccccgtaa atatgtttgc
|
235021ttctttttcc tgaatcaccc tcttgtgtga aaaggattgc ttaccactga tctaacaggg
|
235081tcttgaatac agggtccctc agagggtaca agaagcccag gtgttcaggt tattaaaaaa
|
235141tgaagaaatg caaagcagga ttacaacatt tttggcacat tatagatcct cacacaacaa
|
235201atttacattt tcacacacac tcacgcacaa acacacatac aaagtcaaat acacaatgta
|
235261aaataattat gatcacaaga ggatgatagg ctctacattt ttaaatattg actcagaatg
|
235321ccctgggaat gacgtggtca aggcacagac tgtgcatttg acactttgtg atgaacatct
|
235381tggtgcacat ataatctagt gcacagataa tgtcaaagtc tcattagaat cctccatgga
|
235441accaggtatg gtggctcata cctgtaaatc ccagtagttt gggaggtcaa ggccagacga
|
235501tcacaaccag gagttcaaga ccagcctggg caacatagtg agtccctgac tctacaacaa
|
235561atttaaaaat tagccaggcg tggtggcacc cgtctgtagt ttcagctact tgaggatcac
|
235621ttgagcccag gaattggagg ctgcagtgag ctataatcgt gccactgcac tccagcctgg
|
235681gtgacagaga aagaccttgt ctctaaaaag aagcctccag gaatgggaaa cccaagttaa
|
235741atcagctccc actccaccct aactcccttc ctaagccttc cttaagggaa aaagaacaaa
|
235801atactgagcc cagtagtaag gaaagaNcag tgaaagcccc agttaggaaa ccatgaaaga
|
235861gaagaaatga ggtacacagg gagaaaacgt ggatgaaaac cctagactat ggccaccaac
|
235921agacccaagc tagccaggtg tagacctctg tgacacctag aggtcaagtc caagaggtca
|
235981gctgaagtta cgaaaggcag gcaggaactc aatcagctac ctacttgtcc acgagctagc
|
236041cctccccagg cctggcatct atgcttacct cctggcccac tcctgctggc ctctccacag
|
236101gcacaggtga ggccctaaac accaggaatc ttctaatgtg tgctgccttc tcccacgtct
|
236161gtcccatttc ctaggagtta atcatggtgc ccattgcaac atggcaccca atgccacttt
|
236221ccagagtagt gtgacgtcca attccaagac ctggaggata aaaggtatta aagctcctgg
|
236281gaccacagaa gagacagggc agaaagctgg tggaaaacca tctccaacat ctgtttcttt
|
236341ttctgttaaa atctatccac tgtgtgaatt gccaaggaaa gttaagattc ctgttctgaa
|
236401acgagaaggg ttctcttttc acatgacacc tgcagaagat gggaaacatg ataccccctg
|
236461cagatcagag gacaccggct ccctgtaaga ggatacccca acccttgtca gtgcagcacc
|
236521cggcagggcg atttttacat ttttctcctc ttgctgaagg gcctccagaa aggccaccag
|
236581ggctttcccc aagagtaaaa ttctccccag ctccctagga ggtctcactg cccaccaccc
|
236641ctttatttag ctaagtagca gagtttttat tttactgttt attttatttt attttatttt
|
236701attttatttt attttatttt attttatttg agacagtctc cttctgtcac ccaggccgga
|
236761atacaatggc atgatctcag ctcactgcaa cctctacctc ctgtgctcga gcaattctca
|
236821tgtctcagcc tcccgagtag ctgggattac aggcacgtgc caccacaccc agctaatttt
|
236881tatattttta gtagagatgg ggtttcacca tgttggccag gctagtcttt tttttttttt
|
236941tttttttttt Ytgagacgga gtctcactct gtcgcccagg ctggagtgca gtggtgcgat
|
237001ctcggctcac tgcaagctcc gcctcctggg ttcacgccat tctcctgcca cagcctttgg
|
237061agtagctggg actacaggcg cccgccacca cgcccggcta atttttttgt atttttagta
|
237121gagacgaggt ttcaccatgt tagccaggat ggtctcRatc tcctgacctt gtgatctgcc
|
237181cacctcggcc tcccaaagtg ctgggattac aggcgtgagc caccacgccc agcctaggat
|
237241agtcttgaac tcctggcctc gagtaatctg cctgcctcag cctcccaaag tgctgggatt
|
237301atgagccact gcacccRgcc agtagcagag tttttaaata acttccagag ccctttactg
|
237361gaRacacacc caagaagatg ggctcttatt cttcccacag aggactatag accatcaact
|
237421aaattcactg gctcctactc aagctataga aagctgagga ggaccttgga acatcctctc
|
237481taaattcctc ccctagttcc agtccaggta aacaaaaatt gattctattt tttcaaaaca
|
237541ccagcccctt cagatggcct ggttaatctt cattaacatg ttatcttcat taacatgttt
|
237601atcttcatta acatatttct cagtgataag aagggcccag ggttcaacat cccactttgc
|
237661atccatgcag acaagggctg tgggaagctg taaaactgaa gaggcggtga atccaggagg
|
237721gattccccag atatccgtga gttggtgttt gactttcttg aacacgtctt tcctttactt
|
237781tacacttaca cttactgagc attcactctg gaccagaccg cgtcctaaga gcttcacgtg
|
237841tgtggtcatt caatcctcaa accaatccta tggggtaggt actggagtta agtgatggcg
|
237901ctgggatttt aacccagaag tctgattgca aagcccaact taccatgagg gccacgacat
|
237961atgtctctac ttacggattc caccagtact cttgacagga gcatttacct cactatatta
|
238021taagccttga tctacttttc tatctccctg aagcataatc agccataatc tgctaaccgt
|
238081gcctcagttt tcattctcct ttctattttt ttttcagcgg gggcagggga gacagaatct
|
238141tgctctgtca cccaggctgg agtgcagtgg ctcaatctgg gctcactaca acctccgcct
|
238201cccaggttta agtgattctc ccacctcagc ctcccgagta gctgggatta caggcacgta
|
238261ccaccatgcc cagctaattt ttgtattttt agtagagacg ggctttcacc atgttggcca
|
238321agctagtctt aaactcctga cctcaggtga tccacccgcc tcagcctccc aaagtgctgg
|
238381gattaaaggt gtgagccacc gcccagcctc attctccttt ctttattttt atgatagcct
|
238441ctaccttgag tttcacccaa gcctatggcc atctgctcca aactacattt cccaacatcc
|
238501cttgtggcca ggtgtggcca tgggcctaag ctaagccaat gggatatgag tggaagctcc
|
238561ttaatgacaa gctacttgcc tttggatttc acctcctgct tctcacatcc tgaaatacag
|
238621acttaaggat acaaaataga ctaaaacctg ggtccatgaa tgatgacttt ctggacctac
|
238681cttacctgcc tggtgtgctc gccaaacgac ttatttgaca aataaataaa cttctgtctt
|
238741atttagcttt tttaattttt tttatttttt tttggacaca gagtctcgct ctgtcgccca
|
238801ggctggagtg caagtgcaat ggcgcgatct cggctcactg caacctctgc ctcctgggtt
|
238861caagcKattc tcctgcctca gcttcccaag tagctgggat tacaagcatg caccaccatg
|
238921cccggctaat ttttgtattt ttaagtagag acagggtttc actatgttgc ccaggctggc
|
238981ctcaaattcc tggcttcatg tgatccgccc gccttggcct cccaaagtgc tgagattata
|
239041ggcatgagcc actgtaccta gacttatgta gccattctat ttggggacct ctttgttata
|
239101gcagcttagc ctgtatgctg gattcagcac ctgaagtccc acagcttgtc ttattctatt
|
239161caacatctcc agaacccttt cttagggctt ggaacatagt agttgctcag taaatatttg
|
239221ttagctgaat gaaaacacca ttatgtaaag caggtagtac cagggctaaa caaactgatt
|
239281tactcaagct gtgcaggtgt cccgtatcca ggtgactaca atgtttcctg ctttcctgga
|
239341aaacaggagt tcaggacaga gagagtaggt ttaggaaagc atttgcaata ggaaaggggt
|
239401aagctttcac tgcatctgtt gttggctctc tgctgagaca acagattttg ggcttaatca
|
239461aaagttagct gaggttactt cttgtctgat aaaaataatg ggctccattt gagcacttac
|
239521tgtgtgccag gttctgtact aagcgcttca catacattat ggcattcatt ttcattcaat
|
239581tctcacaata accctacaag gtagaaaata ttaatatctc cagatgaaca aaccaggccc
|
239641ccaaaaaagt taaataactt gccctagctg catggctcgt tagtgacaaa agtaaaattc
|
239701aaacccaagt tgtttgagcc taaacttact ctcttcataa ccaatctgcc actctgcttc
|
239761tcttcctgtg tgacaagcca atattcccMa ctatggttat aagtttcaag ggctggacca
|
239821cgttttgtgc ttatctcaat agacgccaca ggcacggagc ttccactggt ggctgtgaca
|
239881cttcttctct gtgcatgatt ggtgaggggt tgcacacacc caccaggaga catgacggca
|
239941gagggcaaac actctgagac ccagggtcca cccagctctc ttttgccctc tcctctccct
|
240001gggctgcccc ggctgcctcc ttgacctctg cactcttctg cccacgctgc tgccgcccac
|
240061atcttggaca gcatcccccg gggccgcctt cctgcctgtc tttgtgtaca attcctgcca
|
240121ggcccggcag ttctcctagc taaagccggc aaggtccaga cctgcccgtY tggcctggta
|
240181atggtgtggt ccacatttca cctcccacct tcaccctaac ttcatcctca tggccattct
|
240241ttatccacaa caactccttc ctccccattc cctagactca gcaaagcagt caggagctag
|
240301gcaaggtggc ctttatccca gaggttggga taaacctagg gctcataaat ctagggctgt
|
240361gagccaaata cggcccctgg gattgctttc tggttgtgca ctatgctttt tgaaaactga
|
240421gttagctagK tttaggctgg gcacagtggc tcaYgcctgt aatctcagca atttgggagg
|
240481ccaacctggg tggatcacct gaggtcagga gttcaagacc agcctgacca acatggtgaa
|
240541accacatctt tacttaaaaa atacaaaatt agccaggcat ggtgtcatat gcctgtaatc
|
240601ccagctcctt gggaggctga ggctgaagaa tcgcttgaac ccaggaggtg gaggttgcag
|
240661tgagccgaga tcataccact gcactccWgc ctaggcgaca gagagaaact ccatctaaaa
|
240721aaaaaattag ctaggtttaa agtcattaga ggtcatataa aaatgcaaat ttcaaacttc
|
240781tctcagaaaa tcaggagccg tgacaacact gggctcacct ccccatgtgg caaatggctt
|
240841gggttgaatg tgaacatcct ccctggaagg gcataaactt cccagttgac cacagtacag
|
240901tcccccaacc cccacctccc accaactccc tattcttcgt ctcctacagg tttacatggc
|
240961ctgactagcc cccagaggca ttggagtttg acacgcccac agcagtgcct ccattttgcc
|
241021gatgagcaaa ctgagaaaag gcaaagagaa attagtcccc cagatctcca agtgagttca
|
241081tcagcaaatc cagggctggc aatcattaga caatatttat ccagctccca gatgtccccg
|
241141cccctgctct gttcagtcac tgcactcatc catgtggctg ccccaatgcc ttgggcatgc
|
241201cagagagaca cctcattctt tcaacacaca ggtcacaaac atcttttgtg ccatgacaat
|
241261ctgattctcc tcacgtcacc ccaagattaa ctcttttcaa atctgtggtt cagattatac
|
241321accctgaagc tgctgagggg tgacctctca ataaggctaa tctcccctgg acctaaatac
|
241381tggtggggcg tgtgtgcatg tgtgcatgtg tgtNtgtgtg cgcRcgcgca tgtgtgtacc
|
241441catgtgaact cgctcatgca tgtgcttcta gattaacact ctttcttctc attaacttcc
|
241501cagacaggtg agaagtcaac atttgcccca gttagagaac cagaaagtat cagtcccact
|
241561gccccatcta aaggggcagc agctgctgat ggttgccata gtggaatgaa gattcagggt
|
241621tgccagatct ttcaactttt caagaagcca ggaatataac ttagaagagg ggagcaatgg
|
241681tctctaaaga cctgtgctga gaaacaagtt cctaagtgct tgggagaatt tatgaggacc
|
241741Rggtgctaga gaatgccggg aaatgaaYgc tcccctttga acgtcccatt ggtgaggtca
|
241801gaactatgtc ctcaatccct catcagccta tcccaggact ctgaagagga ccccagggtg
|
241861cttggctggc tttgccttcc agcctaagaa tgtctttgac taatattttt cttaatccct
|
241921gtttgctctg tcctcaaaac aagccttttt ctctttttct tatccatctt ctccatagag
|
241981ccctcaggtt cttaactcac acggcactat ctggatcttt ccagtaagta ggttgccgtt
|
242041tccatttctt tgattaaaca actctaacaa agaattcatt gagatgaaaa tgcttatcat
|
242101gaagcaggta acatcctttt cctccccaaa ccacaagcaa ttaacatata aatggcctgg
|
242161caaagggact tctttgagag gtggcagatt ataactactc ttgctcctac acggataaag
|
242221ctttttttta aagacaggaa agaacaattt acaaatgaga aaatgtcaca gatggccaca
|
242281aactaacttc ccgagggatg agtattttga tgcagatact tcttcaagtg aaaaatgtac
|
242341aatgtacaaa atgtccactY gaggatctgt tcctccccgt gtgggtaatc gccctcctac
|
242401cacgggcaac gggtaggcaa ccgatatgcc cagaaaggcg gccaatggga ggacagctcg
|
242461cccagcctcc cgattggcca ggcccgccac cagctggaac catggcgagc tttgaggaca
|
242521gcagagccac ttgatgggat tctctctctc ttcaaagcat agagcaaaca tcaattaatc
|
242581ctcaaaagac gctttcaaga agaacattat cccttttgga gacgcagaag ctaagaggtg
|
242641ccgcaggtag gtgaagggaa ggcaggaagt tgaagaggag aggagaaagt ggagcaccgg
|
242701gctttcagcc ccagttctgg ttctcctgag agagtcaagt tgcaggagaa gaatgaacct
|
242761gcagaagccg ggcagggaga ggtggtggag aagccgctgc tcttgggtgc gcccctcaag
|
242821gcttcccact gccccatccc ctaggagacc acggagtgaa aaaagttgga ggcctaagta
|
242881cagccgtgtg tacccagccg ggcaccagag ttaagacaac tggacttgtg ctcaaaaacc
|
242941cttctttagt aaaacaWccc gtaggagtct gtgggaggag gaaaaattga agtctggatg
|
243001caatttgcca cactgagtct gttctggtaa ccgcccccaa cacactcaca cccccttgcc
|
243061tgaaatgggg agaggggtgg gatcggtgtg tgtaaacaga ggcactgccc tgcctggctg
|
243121ctctttccat cttaggagaa ccaatccaga actttctacg gctcacactc tgatcacagc
|
243181ctgtcgccat gattggcaat aaacgtcaca cattctcacg ttatacattt attcgacctt
|
243241taatattgtg ctctgagatt cctggaaaac ttgtatgtca ttggtcaaac gttataaaaa
|
243301cagcccacta ttttttcccc actcacatcg tccgtgttga ctgccttaca caccRatttc
|
243361tacatggaat gtttttagcc tgcattttaa cacttagaat aactttcttt gccacacact
|
243421acatacatac tgtttgcatc aataaacaga gcccgtgcca catgcaagtt ataggtttat
|
243481tggagacatt taagtgttta tagaaaggac ttttctaaag aatctgaatg ggagttctct
|
243541caatttacca atagtcaaag aaataaagaa aattacccta cagctgattt tttttWaatt
|
243601aaactaccaa caactattct gccatagcct tgcgtgtgtg tgtgtgtRtg tgtgtgtgtg
|
243661tgtRtgcatg cttgctgagg catagaaaat atctggaagg atttacaaaa actccttagc
|
243721tttggggaac agaatggaca gacagagaga aaacctcttt ttttcttgtt ttatgttctt
|
243781taYtgtgcat tgtttacaat cagcatgttg ttgtttttYt ttttaagact agtcaagagc
|
243841agcagtgaga aagggggaag gaaagaacaa ggagttcaat ctgtaactgt gaacaatcaa
|
243901ttgagataac tcactaccct cagactagcc accatgttgc tttttaaatg tttcaaatca
|
243961caaaatgaaa aagttactct aagatcatct attttttccc caggtgtggt attttgtccc
|
244021catgcctgtg caaagtaagc cagtagaatt tagaaatagc ttgctgcctt tttttttttt
|
244081tttttttttt tgagatagaa gcttgctcta ttaaccaggc tgcagtgcag tggcacgatc
|
244141ttggctcaac acaacctctg cctcccagat tcaagtgatt ctcctgcctc agcctcccaa
|
244201gtagctggta ctacaggcgc ggaccaccat gcctggctaa tttttagtag agacggggtt
|
244261tcactatgtt ggccaggatg gtctcaaact cctgaccttg tgatctgcct gccttaggct
|
244321cccaaagacc tgggattaca ggcatgagcc accatgcccg gcctgctacc ttttttacat
|
244381acacaaaata attgcaaact ttcactgcag tactgccaac cctcatgtca ccatctacaa
|
244441tgtaccacgt caagaaagga caatatcttc aaacccactt accagaagaa aaggttgaag
|
244501ctgtatttgg caggatactg acatacaaac ctccaagatc tgggaaacaa ctcaggctcc
|
244561ttgacttgac ttccttaacg atgacttgag aaacaccaga aagtccagaa cacataaact
|
244621catgaaacca accaatagac tggaatctct cctgttatta aagtcatctt tttggccagg
|
244881cgcagtgcct cacacctgta atcccagcac tttgggaggc caagatgggc ggatcacttg
|
244741gggtcaggag ttcgagacca gcctggccaa catggtgaaa ccctgtctct actaaaaata
|
244801caaaaattag ccaggcaagg tagtgcatgc tatagtccca gctactcttg aggctgaggc
|
244861aggagaattg cttgaacccg ggaggtggag gttgcagtga gccgagatca cactctactc
|
244921tctctactct actccagcct gggtgataga gtgaaatcct gtgtcaaaaa aaaagaaaaa
|
244981acaaatcatc ttttattctc ttaaagaatg aatttttcat gggccatcaa cttcttcagt
|
245041catttaagta tttgtttaga gaatatttca gttagaaact caggaaatgg agacctgacc
|
245101tcaaagggcc ctttccagtc ataaagtaat tagaaataaa ataaaaacag gttgaagtga
|
245161taagctgata agaaaatcca atttgtttcc aaaattgttc acttacagct gtttttctca
|
245221tgaatatagc tatagttgtc atcagcaaat cagtggcttg gaattcgaaa ggagtgaaaa
|
245281tatacatcct gggtctcttg aactcctagt gtttgccaga gctaggcagc aggatcaaat
|
245341ggtcaatttc agcctggccc tgaaatcaaa accctctaac agtcacagaa gttctgcagc
|
245401tagtcagtta cttactgccc acacttcact cagcacaatc cttaaagtca ccagagggag
|
245461cccaaatttg cgacaaacca gaatgctttc cttttagggc atagttgtcc ttctgattct
|
245521acttttgccc tctcctttcc aagactaatt tagaaacgaa gggaagtagg ctaagaaaat
|
245581cctcaccttt aatattaata agacttgtgc agtccccgga tgatcagagc ccagactaca
|
245641taggacttga aagaaagaat gagactttga tatggaatat gaaaaagtaa caggtaggag
|
245701gggtggagag accaaactga gaggcctagg gcccagcttc tgcagctctg tcactgactg
|
245761gcccRgtgac gatcacgcct atttactaag cagggatgac ctacgcttac ctgtctacat
|
245821ttttatctgt gagatgaacg aaatgaaacc tccaatggtt tatttgccat gacaattttt
|
245881aaaaatcagt aggaatgagg gaattaggaa ttgagcccat gctatacctt cttttcaaaa
|
245941gagatttcac atgtaccatc tcatctgtat tcctggagag atagtagccc attatgagtg
|
246001gctccaattt acagaaaaag taactaaggc acagagtggt gatctaccca ggacagcatg
|
246061gtctgtagaa gaagcattgg tctgtttaKt gcattgaaat gtattccaga gatattggtc
|
246121tgtaaagacc ttcccagaat gtgtctagaa ggttcaacca cctggtggaa gacatagaac
|
246181gccttgtcat gccttcccca ttccagcctg gagttctctc catggtctca gcctgcttct
|
246241atgaagctta gttttatagg gagcctttta accaagccaa cctcagagtc ccactggcca
|
246301aggggatggt gggggaggca aaggattcta ctggggcagt atgtaaccca catataagtt
|
246361ccatccaaag caacgcttcc aaacctagct caccaggaca ggagaaaggt taccatcagg
|
246421gtactcttag ctgagaactc atacctttcg ggctttYatt ggcttgaggc atgagtgatc
|
246481agcaRagccc cacatcacaa tccctgtact cagatataaa ttatattagt gggcaKggaa
|
246541tgtcaggaaa cttaggttgt agaatctaga tcaacaactg cttacYgagg agctgggtga
|
246601attgtaaaga aagaaagaaa caagtgttga atgactgtgg cctcattaaa catttctgtg
|
246661gcctggcctg tgctttgggc tttcccagag ctgtttcatg caatagcttt gggcagggca
|
246721cttctttgga cttactccaa ctacacaagg aggaggagga tgtctatggt tctttccacc
|
246781ccagacacag tatcagtcac agccccacct taattccact actccaattc tgttctgagg
|
246841gtatcacagg atgctgtggt gggttcccca gccccacaaa atccttttct cctctaaaac
|
246901aggagaacat ctttccttcc tttctgatca tccatcttgc agccagcagg actcccagcc
|
246961agaacattgt caatttactc agggatccat gaggcacctt ttggaagatg agaggggttg
|
247021ggtgaaaaaa ggaagaggaa gtggggtgct ggtacttctg gaaacaagcc atttctcagc
|
247081ctgctctgtg aaggtccccc aaaccctaca cagatctagg aagggaaact gcattccaag
|
247141aatgcatggg ggctagaagg acccgctgga gcatggatcc cacccacagg agataatatt
|
247201ttgaaaagag cacacattta accagggaag aagagcccat gccctggctt aagagcatag
|
247261ctgtttcctc ctccatctgc ccccattttc ccaggcctga ctagagcaag tagttaagcc
|
247321aacccaaatc cagaagtatg aataatgcgt gaagcMcagg aggacaggca gatggccttt
|
247381tcacctgcgc aggctatata gctctgtgcg gaggggctga gagtccagcg cggcccctgt
|
247441gcccctcagt aactgtgcaa gaggaagtgg gcctcccctg cgggggtatg aaatgtgggg
|
247501cgaggactta ggagttcacc gggaagtgcc agccatcctg gggcagacac caagagctgg
|
247561agtgatttgt ttWccctttt ttcatgagtt aatttgcttc cagcagattc cattagtgac
|
247621ctgacagacc aagggcctgg aggaggtccc tggaagagct gctgaatcag cagactaaag
|
247681gggcgaccag gaaggccaga cgtcttgcac cgagcccttt gctcagagtt tctatttgaa
|
247741gagcttagaa taactatttg ctaagctctt gtcaaggcag cacctctaaa ccatgtatgg
|
247801agagaagaca cacaaacctt gaccaccaaa tgtgaatggc caatcagaag ctgacacaat
|
247861cagctgctga ctgaggaaaa atgattttat gggggaaaag aattcccaca tgaaataata
|
247921agcaaaagtt ataaacttat taaaaagctt gttaaaaact tacttaaaaa gcaaaagttt
|
247981aaacatggtt ccatctgcaa ctaggaactg gtcggggagg gagggtttga acttcctttg
|
248041agtttcaatt gataatcccc gaagattaag aaaatagtga tactattact actgctgctg
|
248101ctattattac aaataataat aactacaatt aacatttatt tggcacctag tacatgctag
|
248161gaagtaggca atRagttttt ttgtttgttt gtttgtttgt ttttgagatg gagtctcact
|
248221ctgtcaccag gttggagtgc aggggcgcaa tctcggctca ctgcaacctc cgcctcctgg
|
248281gttcaagcaa ttctcctgcc tcagcctccc gagcagctgg gactacaggc acacgccacc
|
248341atgcccagct aatttttttg tatttttagt agagacggcg tttcaccatg ttggccagga
|
248401tggtctcaat ctcttgaccc tgtgatccgc ccacctcagc ctctcaaagt gctgggatta
|
248461caggcgtgag ccaccacgcc tggcctgcaa ggagttcgtt atgcatgatt tcatttactc
|
248521cttgcaacat ctctttgagg tagggaaact gtgtgggtga gaaaagtcac atagctgcta
|
248581agtcatagaa aacgttcaga gcaaaatcaa acccaggtgt aggccaggtg cagtggctca
|
248641tgcctgtaat cccaggactt tgggaggctc aggcaggcgg attacttgag gccaggagtt
|
248701caagactagc ctgggcaaca tggcgaaacc ccatctctac caaaaatatg aaacaaatta
|
248761gccaggtatg gtggcataca catgtggtcc catctactca ggaggctaag gtgggacgat
|
248821tgcttgagcc tgggaggcgg aggttgcagt gagccaatat cacaccactg cactccagcc
|
248881tgggtgacag agttaagact ctatctcaaa aaaaNaaaaa aaaacccagg tgtgtccaac
|
248941tccaggcttg tgcacttacc cactctgcta tatggctaaa tcccacaggc tacagagaga
|
249001gcagggaagt aggactcagg agaactgcct ccagccccac aggcaccctg actagctgtg
|
249061ggatcttagc aagtgatttc aacttgtggg ccatcgtatt ccatcagatg attgatgtct
|
249121tagggacccc ttcaattcaa accacagtta ttggtggact gcctgagtgc caggcactaa
|
249181gatagggggt gggggaatgt ataaacaaaa ctaaggcgtg gtccttccct ccaggagttt
|
249241acagtctagc cctgccttat gcaaaagcca aagagcctta ggtgtccctt caggtctaaa
|
249301atactactca gagattcctt ttgaacatgc aaagtatttc tgaYagcatt catattcatc
|
249361ttctatttgt tctgtgtgga catttgcatg gagaggtatc tgaaattatg ttcgtccaat
|
249421ggatttgggg tgataatttt gctctcatct ttttactttt atgtgttgct tgaattttta
|
249481gtaacaaata tacatcattt ctataaaaac aaaggcattt ttaaaatact gctaaataac
|
249541actatatatg ggtgtatatg tatatgtata tatgcacaca catacctata tacacatata
|
249601tatttaaaca gtaactggat atttaataat actgtggaat tattgttaac tcagataaga
|
249661ttgtgactag gtttccagaa agaatcttta ttttttgcag atacatactg aaataattta
|
249721cagataaaat gatgtctgag atttatttca aagtaatctc tagtgtgaga gggtaggagt
|
249781aggctataga tgagacaacg ctggctctga gttgcaagtt gtggaagcaa tttgggtgct
|
249841aggtgatggg tataagagtg ttcacgatac tacataggtt tgaaattttc catactatac
|
249901agtaaaaaag gaactccttt caaggccaac agggaagcaa catttcccca aagctaagct
|
249961aagcacccag ctggcagcat ttctacctgg ggtttctacc acccttggct tcctctcttc
|
250021tttgactatc tatcacagtt taacttcatt ggttctctgc agcttcctcc ccccccccNN
|
250081NNacaccatt cccccctaac cttctggaat cacgtgttgt atctatttgt acattccagt
|
250141gcccaggcca tccctcttcg accttaccct ggcccagggg acagagcggg tgggcctgag
|
250201caatgctccc acacacctcc gctcaaagtc agctgtttgc tgtagaggta gaacagcttg
|
250261actactgggg gcgagggtca cagttcactc attcccccag caaatacgga gccagatgct
|
250321ggggactcag cagtgaacaa gaccaaattg ctaccttcac agagttttca tgctagagaa
|
250381ggagccaact ataaatgtta tctcccatcc ctcccagatt tagggccagg ggtatattca
|
250441ccaagacatt cctgaatcac ctgggatctt gtcccaaata atttaaacct gaaagacatg
|
250501atctagtgcc aagagctaga ataccaccca actacccatc ccaatccagt tccccattta
|
250561actgacaaaa aaaaNaaaaa acagaaatgg tgtaagccca ccatgtaagt aaacataagt
|
250621aaacagtggc agaggaaagg gtacccagac ttcactgtgg caggcccacc tgggaccaca
|
250681ttcagaattt ttacaagctt Wgctgcgatg ttgaccaaag ttctccccac tttttttcat
|
250741ttgcttgaat ttcactttta tttttattaa catcttttgt tttgttttgt tttgtttttg
|
250801agacagggtc tcaccctgtt gcccaggcta gaatgcagtg gcacaatcat agctcactac
|
250861aatgtccacc tcccaggctc aagtgatcct cccacctcag cctcccaagt agctaggact
|
250921acaggcacaa gccaacatgc ctgtcttatt ttgttttact ttttgtagag acaatgtctc
|
250981actatgttgc cgaggctatg cttgaactcc tatgctcaag cgatcctacc acctcagcct
|
251041cccaaagtgc tgggattata gtcatgagcc accacacccg gccctttatt aacatcttaa
|
251101atttcgtgtt ataaggcttg ttatacaaaa tagtggtcca ctgcagctta attctttttc
|
251161tttttctttt tctttttttc tgagaaagag tctcactctg tcgccaaggc tggagtgcaa
|
251221tggcacaatc ttggctcacc acaaacctcc acctcctggK ttcaagcaat tctcctgcct
|
251281cagcctcccg agtagctgag attacaggcg tgcaccacca tgcacagcta atttttgtat
|
251341ttttattaga gatggggttt caccatgttg gccaggctgg tctcgaactc ctagcctcag
|
251401gtaatccacc cacctcagcc tcccaaagtg ctgggattac aggcatgagc caccacgccc
|
251461ggcagcttaa ttcttttaat tgaagattgt gatatttacc tacacatctc taaataacat
|
251521gtttttaact gttgtttctt gatttttcag ttttaggctt ccccaagtag gaaagagtgg
|
251581atttaccctt tttgtagcct gtgctttctt atctgttctc actatacaca cacacacaca
|
251641cacacacaca cacacacaca cacacacaga cacatacaca cttcctttct ctccatcccc
|
251701ctatgctcca tctgtctgcc tgcctgctta ctatctatca tctatctgtc tgtctccttc
|
251761ctccctccct ctctcgctca ctctgtgtat gtatgtactg gtgaatatat atttttattt
|
251821ctcaatgatt accgttttta ttgctatgat tatgtaaRct ctattcagaa ctgtgacatg
|
251881tagtattctc tagttacatt tcctccactg gataacttgc attcctggaa ttaataattg
|
251941tcttatttaa ttcatttgct tagtattgta tgtactcacc RctaattcaR acccctagct
|
252001ctccttaagt tgtgtatatt ctctctcaat atgttgagta tgtttctcac ccacttttga
|
252061gggtgaattt ggtcattttg ctagcaaaca tgattgtagc agttttaaaa aacaaaactt
|
252121ccctgccaga gataacttat acaccttgct aatataacca gtgacctcct atgtgagtgc
|
252181ttgatcatgg aaaacattta gccatgtttg gctaatccta acaaagacta catttggtgc
|
252241acgagaactt ccaaatcacc tttcttagca aaagaaagag agaaagaaaa gaaagaaaga
|
252301gagagagaaa gaagaaagag agagaNagaa agaaagagaa agaaagaaag aaagaaagaa
|
252361agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaggaaag aatttggaaa
|
252421aacagcattt tcaatttttc ttactttatc acaataatgg aaatggtgtc ataaggtttt
|
252481aatgcattca tcaaaataca gcatgttcta tattacttgt ggatttacca ttgttctaac
|
252541aaaaaagtat gtattatatg ctttcaccca tagactgtaa gctctaagaa ggcaaaccgc
|
252601ttcagcccta cttttctgaa atatcctcat cacctagcac aatgcctccc atgtaattag
|
252661agctaataaa catttcttga attgaatccc aatgtgcttt aagaatggga gctcagtggc
|
252721acacgaYctg agttagttcc ctgtgccttt atagcaacca gtttgcatcc aggtcccagt
|
252781gaggcccact ggacagttcc ctaacccccc ctgcatgcta tcaacaatgc acctgctctt
|
252841ggccatttcc acctggaagt tgaattggcc tctcaagcct tccagacgaa gtggagccca
|
252901cacacacctg ctgccctcac agtcctcacc atcacaacaa tccacYgtct catcttccac
|
252961ttgctcaggc caaatggatg cctctcttgt tgtcacatcc tactttcaat tccatcttaa
|
253021tcccatcatc tctaccttca aaatgtactc agaatcagct acctctcacc acctttgctg
|
253081ttaccacgtg gtccaagtca ctgcctcctc catctactct caactcagca gccagagtga
|
253141tgctgtaaaa ccttctggta ggtcccaact ccaaggataa gccaaagtgc tcctattcct
|
253201cccactccct ctcactctgc accagccaca tggcttccct tgctgttctt caaaacatca
|
253261gccatgcctc cacctctgga cctttgcacc tgctgttccc tctgacttga atcctcttct
|
253321cctggatgac cctcaaatgt tgcttctcag ggagcttttc ccccaacact cctggtccca
|
253381actccccatt ttagttacct ccataaactt ctcaccatct cacttcttta cttagttaca
|
253441ttatcatctg ggtgccccca ctagaatgca agctccatga aggcaaggat tttgcccaat
|
253501ttgttcactg ctctatgtct agcacccaga atagtgtgac taattcaaca ataagtattt
|
253561gttgaattaa attaatccta ggacacctgg aaatattttt atatccccat tagggaggaa
|
253621aaattacaga atctccttcc agatatatta ttccatttat atatatatat atatatatat
|
253681atatatatat atatatatat gtgtgtgtat acatatatgt gtgtgtgtgt gtgtgtatat
|
253741atatatgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtat ccccaggcct ttctcaagca
|
253801aataaataag ctctaatgaa tttcaaaaga caaagaaatc tcatttcatt ttaacttttt
|
253861ctcacccttc ccaagtcagg gaccacctcc tctcctcccc ggcccaaagc tggaaactgt
|
253921gtgctcagtg gactcaggag gagttgcagg tgccaccgac ctgaaggcaa ttaccaccca
|
253981caagtttcag gggaagagaa gattaccgag aaagggaaga gaaattagca catagatgag
|
254041aaacacatgt ttaaaaactc cttctgaggt catgagtaag ctgattgaag ctggcaccag
|
254101agtgacaaat taatttcatg accctcttgc tttcattggg aaatgtagga ttctaaaaaa
|
254161aaaaaaaaaa aaagcaaccg atgtgtagaa aagggcacRt gtgtctgccc acatgcctat
|
254221atagagtggt ctggtaagaa aacaagctgt tttccagtgc atttgttttg aatgtgcatt
|
254281gagccaccta ctgtgtgccc agcagaccag agatagctaa ggctcaattc ctttactcaa
|
254341ggaactccag caggtgagag tggctagcat agacacagcc caccagaagt cactatgcca
|
254401ctgtgcaaat gttctgctgg caggaattaa gcactagggg cagctgttct gcctagaaag
|
254461aagtctcggg ccttgaagtg tgcatagaca ctggaagagc tcatcaagta gagacctggg
|
254521ggtcggggaa gaagtcctgg cagagaaggt cacagaagca aaggcctgga ggtgggaagc
|
254581ccatggtggg atgtgattca agctcagagt ctgccaaaag gtggtggaat gggaggctga
|
254641aatgtgaatg ttggtctagg gagtctggca tcctcctctg gtaagtgcgc cctggtccct
|
254701ccagagagaa ttgatccctc ccctcctttg catcccaccc acccccatac acactcccca
|
254761gggctcacac ccagctcagg gcctgggcac agggcatcac ctgctccctc ttcatggact
|
254821gcttctcctc ccgacaaatg cctctccctc ccatccagca ggtctctgct caatcaccac
|
254881cttctcagtg aagccacctc tcgcaccccc tacaagggga caaacccaca catacgtgtc
|
254941cctactttgc tttattttct gccacagcat ttacacttgt gtttYtggtc agtgtcggcc
|
255001tcctccactg gactgcgggc tccatgaagg cagggacttt gttttatcga ctgccatatc
|
255061cccagcacct acagtgcttg gcacttagtg agagctcaat aaatatttga caaattaata
|
255121aaaaatgcct gtaacacttg agtgacttgg gttgtttatt tcttcccctc ctacaagatt
|
255181gaaaatggat atgaaagcaa agcttgagct ttcagctctc taccccggcc ctgtgcatgg
|
255241tgctgcccag gttggcactc agtaattagc ggatggatgg atggatggat ggatggatgg
|
255301atggatggat ggattctata atcWgtagga gccatcaaaa gtataaagaa actgaactgt
|
255361gcaatgcctt tcctgtgggg aaaagtggcc tgatggggta gaagcactgc aggctgggag
|
255421gtcaacgagg aagctcctgc cagtgtcccc acaagccaca atgtggcctg aatgggaggt
|
255481gaacagagta ggggacagag tccagagaca tacccaaggt taagccaata tgactcggga
|
255541ccaagtgtaa gtcaggacga ggggagggag gagccaaaga tgatgctcag atttttgctt
|
255601agatgacagt gaactccaag gggaataagc agctttaagg gaagaagttc aattcattca
|
255661ggatggaagt gtgagggagg acatcMaggc agtagaatgg tcaggaggag agagggaRat
|
255721tgagtcacgg gtgctggctg gagtcatggg aatccactca ttcatttatc tttttgagcc
|
255781catgccaggt cccaggcatt tactctgcta gagactatgg acgctgcagt gcccaagaca
|
255841ggcaaggtct gtgctctcat ggaacttact ttcggagagg aaaggcagac aaaggaaaag
|
255901tgagcaaaca gatccataga gataatttct gatattgtat gcactgtgaa gaaaataaaa
|
255961ccaggccatg ggagcatgat gcggggacaa tattagatag gttgggccag gaagggcctt
|
256021ctgaagaagt ggcttttgcc acaatgaggt agagaatggg gatgacgacg aagttcctgc
|
256081ttcttggctt caattttctt gaacaaatct ggggtgaaat catcggctga gagcagagag
|
256141atggaaaggg ttttcaggta aatggaaaaa cattggacta ttctctgcca taggaagaaa
|
256201tggaaagggt gagaagagat tatgatggtg caccgaggac ctcactgacg gctgaaacca
|
256261caggggggta aggagcccat caatgcaggg cgtgtgcaag tttcacaggt ctcatatatc
|
256321Ratgaagctt tatgtccttg ccactgaatt gacatcagca ctaggccggg tgcatcggct
|
256381catgcctgta atcccagccc tttgggaggc agaggcaggc agatcacttg aggtcaggag
|
256441tttgagacca gcctggccaa catgatgaaa ccccgtctct actaaaaaca caaaaattag
|
256501ctgggtgtgg tgatgtgcac ctgtaatccc agctacttgg gaggctgagg caggagaatc
|
256561acttgaaccc agaaggcgga ggatgcagtg agccaagatc actccattgc actccagcct
|
256621aggtgacaga gcaagactca gtctcagaaa aaaaataaaa aagaaagcag cactaatgcc
|
256681ctggcagcaa tgtggaagct ctgtctccac tttgtatgag atgggcttgc cggcttgttg
|
256741atttgatggt aatttagttt gatgggctat gagggttttc attacttggt tttaccaggc
|
256801acattcccac caccacctct tccacagact gaggtcacct cagtctgttc ctgccacagc
|
256861ctccacgcac aagccatcct gcaaattaat caccctcaac attcatcgtg ccaaacctta
|
256921agtaactccc cagcacctgc aggatcagtg ccaaactttt cgcccaagta tttataatca
|
256981ggtccttcgt gacctgtcca gcttctctct cccagtgacc tggctggtgt tctcactgct
|
257041cctttctgaa cccaagctta ttcgaatgca caggctcagg tacccgcctc tgCtccatcg
|
257101ataccagcca tggagtcttg ggcaaatctt gggcaactcc ttggagtttt ctcatcgata
|
257161aaaaagttaa tatggctggg tgtggtggct cacgcctata atcccagcac tttgggaggc
|
257221cgaggagggc ggatcacctg aggttgggag tttgaaacca gcctgaccaa cacgaagaaa
|
257281ccccatctct actaaaaata caaaattagc tgggcatggt ggcacatgcc tgtaatccca
|
257341gctactcggg aggctgagac aggagaatcg cttgaaccca ggaggtggat gttgcagtga
|
257401gcgaagtttg caccattgca ctccagcctg ggcaacaaga gcgaaactcc atccgactcg
|
257461tgatccaccc gactcggcct cccaaagtgc tgggattata ggagtgagcc atcatgccta
|
257521gcccactggt actcattttc taagggtatt cttttctaac cRgaccacga aatctccagg
|
257581ctacctcaag ggtcttacaa ggaggaagca aaggcctagg tgcccaaata ctggtatttc
|
257641aacaggacgg cttttatttt taataaaata atttttatag agatggggtc tcactgtgtt
|
257701gtccgggttg ttctcaaact cccgggctcc aacaatcctc ccacctcagt ctcccaaagt
|
257761gctgggatta caggtgtaac agctttttat aggagttctg cctcctacag cttcatactg
|
257821gaaaatacga gcaaaaaatg ttgagcacat ctatgatgag taagggagat gagttgcact
|
257881gtatggagaa cctgatccca ggcctggccc cacctttttt taactgtgag gcctgaggac
|
257941tatcccaggc catccaggcc tctggtgtca cgtctagata gtgaggaaga acccccttcc
|
258001atggtctcta aggtggttcc tagatctatt attccaagca ctagctctcc tatgagctgt
|
258061actgttgagg ggcagagggg tcaaaagaac cttctccctc tctggccgat agatggttgg
|
258121ggtactctga aagcttctct gttccctctg cccattctcc tctaaggtgt ttcattcaat
|
258181agacataaaa acaagagcat cacactgcaa agtctgaaca attgaagaga tgccccgccc
|
258241tccatgacta tcaaagttgg gggatggata cttgggggtt ctttatacta ttctttctac
|
258301tgttgtataa gcttgatatc ttccacaata agtttgtttt ttgttttttg ttttattggg
|
258361agattctcac tctgttaccc aggctggagt gcagtggcac aatctcggct cactgcaacc
|
258421tctacctccc aggctcaagg gatcctccca cctcggcctc ctgtgtagCt gggaccacag
|
258481gtgtgtgtca ccatgcctgg ctattttttt gtattttttt ctggagacgg catttcacca
|
258541tgttgcccag gctgatcttg aactcctgga ctcaagcaat gtggctgcct cggcctccca
|
258601aagtgctgga ttactgagcc accacaccca gccagaagaa gtgagaataa cagcaataaa
|
258661ctcacctgat tccacccttt catgtactaa ctagatatgg atcttttgag ccctcaaaaa
|
258721ggtactgatc tttttttaaa ggaactacat ctgaacatcg taagattcaa tgccttttta
|
258781accttgcaca ttggagaaag aggtatgaag gaagaagggc aaagggtacc tgggagtcag
|
258841acRtctctct cctcccacca actccatcac tttgtaatgK tctctactag gatgcccaag
|
258901ttcccagagc cctagtctcc tcaattgcat ttttgagggg cctaaaggag accaccttgc
|
258961ctcaaaagca cttgttccgg ttataaccac tcccacacac atttaaagca tccctttgtt
|
259021gttgcatatg cagggctggg aggaacaatg gtgctgaaaY tttccaggac atgaaaatcc
|
259081gattgcatgg cctcacccct agggattttg attcagtggc tccagcggag gaggcccagg
|
259141aatctacctt tccatcagtc acacaggtgc ccctcctgta ggtagtcctc agaggacacc
|
259201ttgagaaaac caaaggaaaa gcagagggag gcaaactgct cagtgctacc tgggaggaaa
|
259261acaatctacc tatagcatgg aaaacctcca aggagcaggc agggagtgtc catcagaatg
|
259321acaggaagga gcgaggcagt taaagggaaa gcaccatcat caaagccttc tccagctaat
|
259381accttgtcct tcctgcatat gctcctatct catttttatt ttctaaattt tacccagaca
|
259441agcttcccca aaacccactc atcctgacct tcccgggctc catcactaaa tctccccatg
|
259501gccaggggaa cttttagaaa gtgtactgga tcaagtccct ttcctaactt caatccttcc
|
259561atggctgctt actgccctta ggataaagta cacagccctc aaacttctcc atcaaggccc
|
259621ttcatgacca ggcctctcct gacctctctt accatctcat ccctctccag tgctgcagcc
|
259681acagtggcct tccatgggtc ccccaacatg cacaggacct tggcacatgc tattccctct
|
259741gctgggatca aatgtttcct cttcaaggaa attttccctc aatgccctag accagaaaag
|
259801gtccccctac tatactcttc tatcttcctg gactttccaa cttaacactg atcccacatt
|
259861tacttacata tttgtgtgat tatatgatta acatctgtct tcccaagtgg accataagct
|
259921tcataaagat agggtctgtg ttggtttggc tcaccatcat gtacccaggg tcacagtagc
|
259981tagtacattg tatgtgttca ataatacaac ataaatgccc agtgcactgt ggtctgggga
|
260041gacatggatg aagaaaaaaa gtgagacgca tgcttgaaaa attcataatg caaatgacag
|
260101gccagtgtga gacggtgtgc ttctcctggt catggccact gaaaatcttc tcgactgtca
|
260161cacggatggc gtcactggat gccacaagat ctcaggctct tcccagtaag agcatctctc
|
260221tgggactgtc cccagaggac aatgagaagg tggcttacct cctggggaat gtggggacgg
|
260281aaaaagaggg ctgggagaga gagagtgcca acctcctcaa tccccttctt gttatctcct
|
260341gaaaatgtag cttagtccct cactatcagg actcagagag agaggtgggg aagagaaggt
|
260401cacagacaga aacgatcttc ctccctccta tctggagcca cagaaacagg catacccatg
|
260461ttatctttga gcttgctttt ttttccctag agatgatggg gggtagggtg agcaggaaga
|
260521ttcagagcag tcagttcaga aaacagggtg tttttctgct tggttatcag acccatgccc
|
260581attcaaggga tgcaaaatag gctgaagttt agattctctg actcggctat tgagtcccat
|
260641caattacaac acatggaaaa aactttggac agttaaaaat aacatagggg cctggtgttt
|
260701ggaagatctg gagtttggaa tgccagcttg tcaagcacag atccctgcct accaaaaagc
|
260761atgtgctggg aactcacata cacaccaacc agcacaagaa ggtcacagat gagcaaggtg
|
260821cctgttacct accaccctga caacagtgtg tcaggccaac ttggaggaca aactctcagt
|
260881cctcagccac tttggtctaa aggacttcca agccctcttc tagctgtgga aagggcagag
|
260941ctcatccagg aaagaagtag tctccttccc cttagaggag gtagccatga atggaattgt
|
261001gggctgagtc cagtcacctt acagagacac ttcacctctg tgtgctgtgt ttctacatct
|
261061gtgaacttct tgttctttct cagaaggacc caatatcagc accaattaaa tagtatgcaa
|
261121taagctgtgc tcctggacaa agcatgccat agataaatct ttcttgaaga ctctttaaca
|
261181catttgttct atgagtaaaa caataaattg ataaaaataa taatgccata gatttctaga
|
261241acttctttct tctaggaaaa ccagtgcttc tcctacttat catttcattt ttttaaagat
|
261301gccagtgtaa ggaaaatatt ggctagtgtg tctcctcatt ttacagatgg aaaaacaggg
|
261361tcactgcaaa cacccattaa aagggtaacg aggctgggca cagtggctca tgcctataat
|
261421cccagcactt tgggaggctg aggcaggtgg atggcttgag gccaggagtc caggaccagc
|
261481ctgggcaaca tggcaaaacc ctgtctctat ttgtattagt ccactttcat gctgctgata
|
261541aagacatacc caagactggg aagaaaaaga ggtttaattg gacttaaagN cctcagaatc
|
261601atggcaggag gtgaaaggca cttcttacat ggtggcagca agagaaaatg aggaagaagc
|
261661agaagcagaa accccagata aacccgtcag atcttgtaag acttactcac tatcacgaga
|
261721atagcccagg aaagaccagc ccccatgatt cgattacctc cctctgggta cctcccacaa
|
261781catgtgggaa ttctgggaga tacaattcaa gttgagattt acgtggggac acagccaaac
|
261841catatcattc tgcccttggc ccttccaaat atcatgtcct cacatttcaa aaccaatcat
|
261901gccttcccaa aagtccccca aagtcttaat tcatttcagc attaacccaa aagtccacag
|
261961tccaaagtct catctgagac aaggcaagtc ccttctgcct atattctata aagtcaaaag
|
262021caagctagtt acttcctagg tatgcaattc caagtgggag aaattggcca caacaaaggg
|
262081tttacagSgc ccaggtaggt ctgaaatcca gcaaggcagt caaacattaa agcttcaaaa
|
262141taatctcctt tgactccagg tctcacatcc aggtcacgct gatgcaagag ctgggtcccc
|
262201atggtcttgg gcagctccgc ccctgcaaac acccattaaa atggtaatga ggctgggcac
|
262261agtggctcat gcctgtaatc ccagcacttt gggagggtga ggcaggccct acctccactt
|
262321tgcagggtac agcctccctc ctgcStactt tcacagtctg gcattgaRtc tctgcagctt
|
262381ttccaggcac atggtgcaag ctgctagtgg atctaccatt ctggaatctg gaggatggtg
|
262441gccctcttct cacagctcca ctaggcagtg ccccagtagg gactctgtat ggaggctcca
|
262501accccacatt tcccttctgc actgccctag cagaggttct ccctgagggc cccgcccctg
|
262561cagcaaactt ttgccagggc atccaggcgt ttccatacat cttctgaaat ctagaaggaa
|
262621atcccaaacc tcagttctag atacctgtgc accctcaggc tcaacaccac atagaagctg
|
262681ccaacgcttg gggcttccac cctctgaagt cacagcccga gctatatgtt ggcccctttc
|
262741agccacagat ggcccctgga gcatctggga cacagggcac caagtcccta ggctgcacac
|
262801agcatggaga ccctgggcac ccacgaaact tcttttacct cctgggcctc caggcctgtg
|
262861atgggagggg ctgccgtgaa ggtctctgac atggcctgga gacattttcc ccagggtctt
|
262921gaggattaac attaggatac ttgctactta tgcaaatttc tgcagccgac ttgaatttct
|
262981ccccagaaaa taggtttttc ttttctatca cctagtcagg ctgcaaattt tccaaacttt
|
263041tatgctctgc ttcccttata aaactgaatg cctttaacag cacccaagtc acatcttgaa
|
263101tgctttgctg cttagaaatt tcttccacca agctaccaat gactttcttc acggaattgg
|
263161aaaaaactac tttaaagttc atatggaacc aaaaaagagc ccgcattgcc aaggcaatcc
|
263221taagccaaaa gaacaaagct ggaggcatca tgctacctga cttcaaacta tactacaagg
|
263281ctacagtaac caaaacagca tggtactggt accaaaacag agatatagac caatggaaca
|
263341gaacagaggc ctcagaaata atgccgcata tctacaacta tctgatcttt gacaaacctg
|
263401acaaaaacaa gcaatgggga aaggattccc tatttaataa atggtgctgg gaaaactggc
|
263461tagccatatg gagaaaaatg aaactggagc ccttccttac accttatact aaaattaatt
|
263521caagatggat taaagattta aatgttagac ctaaaaccat aaaaacccta gaagaaaacc
|
263581taggcaatac cattcaggac ataggcatag gcaaggactt catgtctaaa acaccaaaag
|
263641caatggcaac aaaagccaaa attgacaaat gggatctaaa taaactaaag agcttctgca
|
263701cagcaaaaga aactaccatc agagtgaaca ggcaacctac agaatgggag aaaatttttg
|
263761caatctactc atctgacaaa gggctaatat ccagaatcta caatgaactc aaacaaattt
|
263821acaagaaaaa aacaaacaac cccatcaaca agtgggcRaa ggatataaac agacacttct
|
263881caaaagaaga tatttatgca gccaaaagac acatgaaaca atgctcatca tcactggcca
|
263941tcagagaaat gcaaatcaaa accacaatga gataccatct cacaccagtt agaaWggtga
|
264001tcattaaaaa gtcaggaaac aacaggtgct ggagaggatg tggagaaata ggaacatttt
|
264061ctcactgttg gtgggactgt aaactagttc aaccattgtg gaagtcagtg tggcgattcc
|
264121tcagggatct agaactagaa ataccatttg acccagccat cccattactg ggtatatacc
|
264181caaagggtta taaatcatgc tgctataaag acacacgcac atgtatgttt attgcggcac
|
264241tattcacaat agcaaagact tggaaccaac ccaaatgtcc aacaatgata gactggatta
|
264301agaaaatgtg gcacatatac accatggaat actatgtagc cattaaaaat gatgagttca
|
264361tgtcccttgt agggacatgg atgaagctgg aaaccatcat tctcagcaaa ctatcacaag
|
264421gacaaaaaac caaacaccac atgttctcac tcataggtgg gaactgaaca atgagaacac
|
264481atggacacag gacggggaac atcacacacc ggggcctgtt gtggggtggg gggaagggga
|
264541gggatagcat taggagatat acctaatgtt aaatgacgag ttaatgggtg cagcacacca
|
264601acatggcaca tgtatatata tgtaacaaac ctgcatgttg tgcacatgta ccctaaaact
|
264661taaagtatga taaaaaaaaa aagaatctag aaaaagaagt acaaattcaa cctaaaacaa
|
264721gcaggagata ggaagcatta taaagattaa agcagaaatc aataagaaaa aaaaaaaaag
|
264781aaatttcttc caccaagcca ggtggagtgg ctcacaccta taatcccagc actttgggag
|
264841gccaagatgg gcagatcacg gggtcaggag ttcaagacca gcctggccaa catagtgaaa
|
264901ccccgtctct attaaaaata caaaaaaatt agccaggcat ggtgatgcac acctatagtc
|
264961ccagctactc gaaaggctaa ggcaggagaa tcacttgaac ccaggaggca gaggttgtgg
|
265021tgagccaaga tcctgacact gcactccagc ctaggcaaca gagcaagact ccgtctccaa
|
265081aaaaaaaaaa gaaaaagaaa gaaatttatt ccaccagata acctaaatca tctctctcaa
|
265141gttcaaagtt tcacgaatct ctaggggagt ctctagggga gggggcaaaa tgccRccagt
|
265201ctcttcgcta aaacataaca agagtcacct ttgctccagt tctctacaag ttcctcatct
|
265261ccatctgaga caacctcagc ctggatttta ttatccatat cgctattagc atttgggcaa
|
265321agccattcaa caagtctcta ggaagttcca aactttccca cattttcccg tctgcttctg
|
265381agcctttcaa actgttccaa tctctgcctg ttgcccagtt ccaaagtcac ttccacattt
|
265441tcgggtatct tttcagcaat gccccactct attggtacca attactgtat tagtccattt
|
265501tcacacagct gataaagaca tacctgagac tgggaagaaa aagagtttta attggactta
|
265561cagttccacg tggctgggga ggcctcggaa tcatggcagg aagtgaaaga cacttcttaY
|
265621atggcagcag caagagaaaa tgaggaagaa gcaaaagctg aaacccctga taaacccacc
|
265681agatcttgtg agacttattc actatcacaa aaatagcatg ggaaagactg gcctccatga
|
265741ttcaattacc tccccatggg tctctcccac aacacatggg aattctggga gatcaatgca
|
265801agttgagatt tgggtgagga cacagccaaa ccWtatcact actaaaaata caaaaattaa
|
265861ctgggtgtgg tggtgcacac ctgtggtccc agccacttgg gaagctgggg tgggaggatt
|
265921gcttgagcct gggaggtcga ggctgcagtg agccatgatt gcgccactgc attccagcct
|
265981gggcaacagg gcaagaccct gtctcaaaaa aaggatattg tgtgccgact ctactaagca
|
266041ctttacatac attaacttgc ttaattcttc caacaacccc ataaagacaa aaactattag
|
266101tcctacttta catatgagga aactaaggca tagatgttag gaatcctacc caaggccata
|
266161gggcttgaac ttgaacccaa actctctggc tccagaggct gcacccaagc cgtgggtcac
|
266221acagcaactg ctcccagcct cctgctcccc accatggagt gtctgagctt acaaagtgtg
|
266281caaagcttac aaagtatgca aggaacgaac cctaaggact tgtgtaaccc ccagcctccc
|
266341cgtgaaaact aggcccaggg catttctgga aggaagtggc cagcacRcag gtagacagct
|
266401gcagcagtgg caggggtgtc tgggtgggaa ccaggcagca ctaccatcag aataaaccac
|
266461cccgatcccc ctaggaggaa acccactgtc ttagagacct gcagcctcac tctcccctat
|
266521ttgaatcatg aaactaatcc tcagggcacc atgctttaag ctacacaggt tggcatttac
|
266581attttcctcc ttggattgga tttatatatt ttatttacat catttattgg ttgttgttga
|
266641agaagaagaa gaagaggagg aggaggaaga gaaggaggag aaggaggatt aaagtacaga
|
266701aagggaagaa gtcatttggg tccactgctc aggtgggctc tgcccacaag tctgcccagc
|
266761gttgcaaatc ggcccttgca gctggacaga gctggcctgt agctgacagg attgatggct
|
266821cacaccagtg tgggccccac agggtgtctc cctcacccca cccctctggg tggtcccctg
|
266881gaaagtatcc aaaatgcata acaaatgaaa ccaaggacgg ggtccagttc aaccccttag
|
266941tgagagggaa gactggagac agacaatccc ccttgctgga ggacacagga tgaccacccc
|
267001accctccccc tggagcctct cttttggacg atgaggagta tgagtctccc caaacagtga
|
267061ctgccaaacc gggactctgc tcagaccaac ctggcccagg cttatttctc atttttccct
|
267121tctgttcacR gacacecccc acctactccc aaccagccaa acagatctgt gtgctctcct
|
267181ccatgcagtc cttcccatct ggccttcctt ccctcagaaa ggaagggtgt ccccaaagga
|
267241atcgctcaaa cgcctcacgt ctttgttcac ttccctttgg tgactaaagt tccccagcct
|
267301caccctcccg agcctaacca gaccccactg tccttctgaa ctcagctcct ctctgaagca
|
267361tcctctgtca tcccagccac aggaactgct gtctgtcttc caatttcaag gacccctggt
|
267421ggcctaggct gatcgtttag cgcagctatt caccacctgg aacctcaYgt gaagcagctt
|
267481ctctcaggaa tgcatgctct gctgcctgta agctttgtcc ttttcctcct tccctctccc
|
267541cactcccata ttcatgagat tgagtgggcc ctccttgggg acaaagccag aatactcttt
|
267601ccttcYtttg tgccccttca gtgctttttg atcaaggtgc aattcatgga ggaaaggaga
|
267661aagacgtaaa tagtgaatga aggaggggac agggatcaga aggaaaccta ggctggaggt
|
267721gcaaactcag ggctctgagg gccttggggc agcttagctc ttagtcaaga aatgaaataa
|
267781gcagcagaaa gcaaaagaaa aaggaaaggc tttccagcgg gctttttctt cccaaggatt
|
267841tgaaaagcta cagtagagcc tggaggagag tgggctgtcc agggctgccg gctctgagtt
|
267901ttggagagag gtggagatgc tgtggagctt ttatactatc cagaccagtt cctctgggca
|
267961gcaaaggagg cacacaccca ggacaatgtt gggcaataaa gattattcca tcatttggga
|
268021gcaggagcgc cttttgttct gcatttctca gggaatcaac acattccaag caggaaaggg
|
268081atgagaacaa atgaccagca ggatggggac tgatagtatt gggtcctctt cattcagcag
|
268141attataaaat aataaaacaa gcatcctact gctgcaagga tagcaagagc tagcaaggtc
|
268201tcaaaaaggt ttcagaattc agactcacaa gccaggcagc ctccatctct cctctgacac
|
268261tcgctgggat cttcagcccc tgagatgaca aacaatgtcc ccctggtgtg ctctggactg
|
268321aggaactatg agaacttcct aaatctcata aaactataga ttagcgttca tccctgctac
|
268381cctgtgcata agtgacctaa aattgaatgg tccgaacctg tttcccatcc cccagagaca
|
268441tgtgtaatta gataaaatga ggacagaata tgtataagta tctgttatac tcagatggct
|
268501gcccagaaag aaaatgagtg ccaggaaccg gacagccctg tgtcaccctc tgtcctgaac
|
268561tgggattgag ggagacttac ctttgtgagt aggttgctag tgcaatatga cctctctgag
|
268621ttaacgaata tttttctaca attcggctcc tgcagcccat atttggcaca ccatcagcat
|
268681tttctctggc tttccatgtt gaaggatgtc tttcagacca ggatctgaac tgaaacttga
|
268741ccctgggagt ccgtgtccac cttgggactt cctcttcctc cttcaggcct ctttctggtg
|
268801gtaccctctt ccaaaaagcc cccaacacag aattatttgg aggacataca aaagttaYaa
|
268861tgatacgctg gtatctctat ctctctcaat acaagagaga aaggccctca cttgagccct
|
268921aggccatcct ttttgaagga tgaatgaagt gatctgctat acttggttgg gacacagagt
|
268981cgtagggaaa atcattctct ctctaggcat tgatactgtg aaagtataca aaaggcattc
|
269041tctcaaagaa gatgtatcca aaaacagtga ctggactaaa gctccatgga acagacagca
|
269101gatgttcacc agaacccagc cttgggttta aaccattaca gtgctttgca tcttctggtc
|
269161ttctctatct taaaaactca aaagaaaaaa gaRtcctcca gtataaataa agctaaagga
|
269221aatcccacac acagctaagc atagaggagg cactgaataa aaatgaagtt gatttatcag
|
269281tggctatcca taagccagag gttacttact cccctgaaag aaagcaaagc aaaaaggttt
|
269341gtctttattt ctcaagacca aagggagaaa gccaagcttt ttaaagtgac caagaaacaa
|
269401gaggctagaa tgagcgaggc tgccacatgt cataaatgca catcctacat gcaagcaagg
|
269461ccaaacctgc atctgtttcc caactcctga aactgaaggc tctttgggga ggaattctgc
|
269521ctttttcaga ttcctgccgt gaaggcagag aatgagaaac atgtcaactt tctagagtgc
|
269581taaaagcaaa cttgggcagc agagcagggt atctgcctgc aggcttcgct cactcaacta
|
269641ttccccacac gtttcctacg tgcctgctag gctaggtcct tgggacagaa aggcacatgt
|
269701ggccaggctt ggtggctcat gcctgtaatc ccagcacttt gggaggccga ggcgggtgga
|
269761tcactggaag tcaggagttt gagaccagcc tggccaacat ggtgaaacgc catctctact
|
269821aaaaatacaa aattagctgg gtatggtggt gtgcacctat tgtcccagct actcaggagg
|
269881ccgagatagg agaatcgctt gaacccagga ggtggaggtt gcagtgagcc gcaccactgc
|
269941actccagcct gggtgagaca gagagagatt ccatctccaa aaaaaaaaaa Raaagaaaag
|
270001aaaggcatat gtggctactg tccctgcctt ccacgccctt actgctaact aactcctgtc
|
270061aattatttca gtgactgaga gagaagagta tgttcagctc tgcatggccc agggcaggtg
|
270121tggccagttc tacctgaggg tcagcaaggg ctccaccagg gagagggacc acttaaacca
|
270181tccagaagat gacagatgtg catcaagtgc gcccagggac agggtggagg tggaggacaa
|
270241tcaaaccgcc tgcccagagg aaaccgcctg cccagaggag ccacaagcag tttgctcaga
|
270301caccagggga atgtgtgaca agagtcgtct ctctgggcag ggacacagag catcccctca
|
270361gactaacaag ttcacacacg tctctcacac tgaggttctt accctagagc ccatgggcct
|
270421ccagggcatc cagagatggg ctcttccagg tctgtgaacc ccataaaacc ataggcagat
|
270481gttcacatct atatgcgtgt tttccgggga gatgatccac aactttcata ggattcttga
|
270541aagggcctgt gattgccaaa gaaaggtgaa aaagaaacac ccatcaagac tgagtagcct
|
270601gcacactaga ctgtggtata gaatccagtt tctccctgtc tgtctcctgc atatggctca
|
270661gtaacagaca tagtaagttt tcagaactag cagaactaaa gggatgagaa gagcattcca
|
270721gtataagcag atggaaagaa attaccattg gcatcaccaa aacaaatacc tgtgtgtact
|
270781gactgtgtgc caggctctgg gctagacttt aaaaaccagt atctctttcc ataaagccac
|
270841atggaagagt gtcttctcag cctcctgttc ctggagccaa tattgcatat tggagtccct
|
270901aaatgtggat tcaagtcacc cagagcaatt cactgcaatc gccagatcag gctcaaactt
|
270961tagttggcag ttgcctagca acgagtaacc ctgaagacac atcaccaaac ccagatgcca
|
271021aaaagggcat tttgtggaca agctagttct gaaaccagcc cctcataagt ctatttgtca
|
271081ggcctccctg gggctgttgg ggtaaggagt agactttgca gccaaaggta ggctgagagg
|
271141agaaagatag aaaggcattg ttttttgttt tttcagacac ggtctcactc tgttgcccag
|
271201gctggagtgc agtgacacaa acacggctca ctgcagcctc aacctcttgg gctcgggtga
|
271261tcctcccacc ttagcctccc aaataactgt gactaaaggc gcgtgccacc acacccaact
|
271321agtttttcta tgggattttg ccctgttgcc caggctggct cgaactcctg ggctcaagcg
|
271381acctgcccac ctaggcctcc aaaagtgctg ggattacaag tatgagccat tgcacccagc
|
271441tggaaagtgt tctgctggtt gtatgttttc ccacctctag ggaataggca tgagaagggg
|
271501aactgagggt taaaggagaa ggcagcctcc agtggagaag gcagcctcca gtagagaagg
|
271561caattggtgc ctcttcactt cctctttcag attgtaccta tggttactct tccaagaagt
|
271621tgcttaacag atgccaccca cacctaaaga cgcataaagc agcaggaaga cttgactgaa
|
271681cgtacatcca gtccttccct aaagccatca tcctcctgca gctccaaaaa ccccactgaa
|
271741ctatggaagg ctggggtgag caggatgata gacctcaaac tacttcaaca agtgaaactg
|
271801gggaagcagt ttttaaccaa ctctccaagg caactcactY ccttacagag gcatgaaaga
|
271861ggcaaagaga tctcattctc taaaattcag agctgttgtt gttgttgttg ttgttgttgt
|
271921tgttgttgtt gttgctgttg ttgttgtttt taacacaaag ctcagaaact ccttaagcta
|
271981agaggcaggt gagactgggt ttcccaagac aaagtttcca gtccaaacca tcacataagg
|
272041ccaacactgg gtattctccc tgtgtcgata gtgggaagcc tgggaagacg gccttcttcg
|
272101gaatccaccg tcccttccct tgaaaggtct tgggggtagg aggaaaaggg gcaaataaat
|
272161atatcagtct ggaggtgatt caggaagaac aaatgcggat gtcaaacaac aaataaggca
|
272221gatataaatc caaataaaat attaaaatca ttaaagggct gctgctccct gaagattggg
|
272281aaaaatgaag agagttaatt aaaagcaatc tccatgcact gctgagccgg ccagccctga
|
272341taaatcaaca gctggggctg ctgtggaggg caggcaaggg gcttcaggag ggggtgggcc
|
272401agctggggga agggggtctg ccactgagat ggctgtgatg gcaaattgaa cacagtgact
|
272461taagtttcat gttttattaa atattttatg accactgaat aaagttattc tttggagagg
|
272521gagaaaatga tgagctgggt aagtgaaggg ggggaagata aggatgaaga ggtattgtct
|
272581gattcaaaac aYacttagga ctgtgacgtt ggaacctctg atatcgcccc caaaggccga
|
272641agctttgggt tttttttctt tctacttgat ctgcaaaggt agctgtgtct tcgtcttcta
|
272701aaatctctct acaaaacttg ggttatgttt atctgaggga ccagggaagg cagtgcagag
|
272761tcagggaaag taatgaagag gaagaaaaga cagaaaagat cctcaaaatt gtcattgctg
|
272821atcaaagcca gacttttaac acaaaactaa aaggtcagca gaaatggtgg gaactctttt
|
272881ttctttcttt acttctttcc ttctcccttt tttctgcagc tagtttttgt gtgtaaaatg
|
272941aaaaagagct ccaaattttg gggctcaatc taagtcaaaa gccagctatt tcagaagtgt
|
273001tagaagaaca ggcccttctc tattctaagg ggaaaccctc cagttcttcc ttgatgaaaa
|
273061tataatcaag agaaatgatt gggggaaagt gtttttttct cctccataga actgggattg
|
273121gaaggggagt gtgtgcatgg ggaaacataa ggaattatgc atttggatat gcattttaat
|
273181taggtggaca gaagcagccg cctgttaatt tttcttgctt gtttccactt agcattcatc
|
273241acaggcagaa ctaccataga gcgctcccac gataatagat ggttctgcat tggctaagtc
|
273301ctcagggaaa ataattagca ggagagaata tattctctcc cctcccactg ccccatccac
|
273361cctgccctcc ccctatcacc agcaccgcgt tgccgcccSt ctccccactc ccctcaccta
|
273421tagtggtttt cctaggaaaa gccgagggca gcagtcagcc tcctggtttg ctagcactta
|
273481ctttgccctg ccaaaaaaca aggRtctagg agaagaaaca gacagatcag aagtctctat
|
273541tggagtggaa gctcctcgat gtagggaggg agtcaggtgg ctgtgctgat tagttctcag
|
273601gggcaggcag gcaatccatg ttggttgtgg gatgaaggaa ctccaaagag gatgagagag
|
273661ttctcgttgt gctcaactgg cagccaaaga tgtatcgaga gttgctggtt gaggacagca
|
273721ggagtaggga tgatgttttt tgcttcattt gctcttgtaa aggaaagttg cagggccaag
|
273781taagtgcagt ggttttcacc tgcaatccca gcattttggg aagctgaggt aagaggatca
|
273841cttgaggcca gaagttcaag accagcctgg gcagcacagt gagaccccca tctctataaa
|
273901aaaattaaaa attaagtgtg gcagtacgca cctgtagtcc cagctacttg ggaagctgag
|
273961gtgggagatc acttgagtca aggagtttga ggccacagtg agctgtgatg gcaccactgc
|
274021actccagcct gggtgacaga gtgatcgcaY tactgcactc cagcctgggt gagagtgaga
|
274081ccctatctcc aaaaaatata tgagaaaaga aaataaagaa agttgtagct ttgcagcaag
|
274141actgaatctg aaccacttcc aaggctggca accaagacat gYatgtaact ctgagatctg
|
274201accccaccgc aatgctctct ggtctacttt tctataaaga atctggcctg gcatggtggc
|
274261ttacgcctgt aatcYcagca cgtggggagg cccaggtggg cagatcactt gaggtcagga
|
274321gatcgagacc agcctggcca acatgataaa acccgatctc tactgaaaat acaaaaatta
|
274381gctgggtgtg gtggcatgtg cctttaatat cagctactcc tgtgtctgaa gtacaagatc
|
274441acttgaacgt gggaggcaga ggttgcagtg agccaagatc acgccactgc actccagcct
|
274501aggegacaga gtgagactct gtctcaaaaa aaaaaaaaaa agaaaaagaa aaagaatcca
|
274561ttcttgccac tgacctccaa tgccaacagc tcactctcct tattcacaag cagatctaag
|
274621cccctgcccc gcctccactt cttctctctc cctcagtcat ctcagttgaa ggaggagcca
|
274681gagaccaggc aaggaccaaa ggcccaagtt cccagaagag caccccactc taccaaccgc
|
274741gcttctgctt cctctggttt ggtgggtgaa ctcaggtcag ggctatgacc ggaaatgaaa
|
274801tgagggtttc ccctgagctc acattctcac ttatttcaaa cccagacaat aggaaaatcc
|
274861cactgagatc ccagggctat ttacacagcc tggatgagta gaccttgcat ttcctgagaa
|
274921acaatgatta gatgtgatgg gtaatgccag aaacatttat ttttgtttta atatttaaaa
|
274981taatgtttaa tatagtaggt attattgact gcctgaggag gccatgatca gctacaggaa
|
275041acttttagtt ctcatagtaa cacctcacat ttgcactttc caccttctga aatgtttcca
|
275101catccattat ttcatgtggg ccgctgcggg gaagccaggc tggaggaagg ggaagggagg
|
275161agaagggaga cacaagctct cctggctgtt tggaaggaca ggcctgactt gctaactcct
|
275221gccccccaag ctatcctgtc atcaccgtgc ttccacccac ctcctgttgt cagacatcac
|
275281atctccatcc acctaggaag ccttcactcc aagcctcacc aggtaactgc tagtgctaca
|
275341gcccctggaa ctgcctcaaa cccaaaccct gacccccacg aggagtccct gccctcaaag
|
275401gaagggggat ataggctggg cacggtggct cacgcctgta atcccagcac tttgggaggc
|
275461cgaggcgggc ggatcacgag gtcaggagat cgagaccgtc ctggctaaca cggtgaaacc
|
275521ccgtctctac taaaaatact atatatatat atatatatat atatatatat tagccgggcg
|
275581taaggcgggc gcctgcagtc ccagctactc gggaggctga gcccggggaa tggggaatgg
|
275641cgtgaacccg ggaggtggag cttgcagtga gccgagatcg cgacactgca ctccagcctg
|
275701ggcgacagag cgagactccg tctcaaaaaa aaaaaacagg aagggggata tgaggggaag
|
275761gcaatccctg tggctgggga tgggagaatt gagtctctgg gttcctagtt cccagtgtgt
|
275821ttatcccaga acgcaatgga ctaccaatag agggagaggc agagaggttg aattctgtaa
|
275881tactattagg tttgggtttt tttgtttgtt tagtttataa ggtggagaat gcctatatta
|
275941tctagaaatg tagccgctaa ttttttgggt ttgtttgttt gtttgtttgt ttgtttgttt
|
276001gtttgttttt tgagataagg tcttgctctg tcacccaggc tggagtacat ggagtacagt
|
276061agcgtgatca cagctcactg cagcctcaac ctcccgggct caagccatct tcctgcctta
|
276121gcctcccgag tagctaggac cacaggtgta caccaccaca cccggctttt ttttttattt
|
276181tttgtagcga cagggtctca tgatatgtcc aggctggtct tgaatgcctg agctcaaggg
|
276241atcctcctgc ctcagcctcc caaagtgcta agattacagg catgagccta gcYtagtccc
|
276301tagattttac agtccaaaaa tgaaggagac ctaggcatag tgaaaaccca aaagaaatga
|
276361aaatggggac tcaaaaacag ccaaaaggtg aaacaaccca aatgcccatc ggcagttaaa
|
276421caggtaaaca aaaagtgggc tatccataca atggccatag aaaggaatca agttctgact
|
276481atgctacaac atggatgaac aaacattgaa gacattatgc taagtgaaat aagccagaca
|
276541cagaagaaca aatattgtat gtttcccctg atatggggtg ctaagaatgc agaatggtgg
|
276601ttcccaggga tggtaggaag caggggatgg aaaagtattg tttaRtgcat acaaagtttc
|
276661tctccgggat gatgaaaagg gtctgggcag ctgggcacgg tggctcatgc ctataatccc
|
276721agcactttgg gaagctgagg cgggtggatc atctgaggtc aggagttcga gacgagcctg
|
276781gccaacatgg tgaaatgctg tctctactaa aaatacaaaa attagccagg tgtaatggcg
|
276841catgcctaca gtcccagcta ctcgggagac tgagacaaga gaatcacttg aacctgggag
|
276901gcggaggttg cagtgagcca agatcgcgtc actgcactcc agcctgggtg acagagegag
|
276961actccatcta aaaaaagaaa gaaagaaaag ggtctggaaa ctgatggtgg tgatggttgc
|
277021acaaggtggg aggatccctt ggggccatga tttcaagacc agtctgagca acatagcaag
|
277081acctccatct ctactaaaga ttagaaataa atgtacttaa tgccactgaa atgcacactt
|
277141taaaatggct aaaatggtac actgtRtgtt atgtatattt tagcacaata aagaaaaatt
|
277201gagggaatgc ctctctctgc tggaggtcag ggtgaccatt ttgttttctc tttaaagtct
|
277261cagaatttac acaccagctc ctgtgtagac tctgatgagt tctgcaacct cctccccctt
|
277321ctctttatgc ttgcaaaaaa actgccatgg aagctttcca ccaaagaaaa gcctgataat
|
277381aatgtcccca ctgaaatctg agatgttctg gagacatgtc actgaagggg aggcatgaag
|
277441tccagtctag tcttggctaa tacccactca ggtaggggct agttccacac aactgctggg
|
277501cacctccatt tcctcagcag taacacaggt atgctagagg aagctcagtg agacatcagt
|
277561acaggtccac ttacttcagc tcactaaaca tccaggtatc tgtggctgcc caaattaaaa
|
277621taaaataagc actttatttt cagattaatt gggataggtg ccatggtaga ggagaaggcc
|
277681agagagatca tggacaaata aagtccagac cggaggactg gctggaaaat tggttaccct
|
277741tctgcctcca aacacacaca cacacacaca cacacacaca cacacacaca cacacaaaag
|
277801gaagcaaaat acagatgttc tcagtgattc cagtctttta accaccaaaa actgagtgct
|
277861tatccacgtc aaaataggcc aattggtctt caagttcctc attctcatca gcttctggat
|
277921gggatgctag tgagaagaaa atcactgaaa aggaagagcc agaggaaaag cccacattct
|
277981aaatggccca ccacctggtc ctcagcctca gaccttgaga agggatagga agttccaccc
|
278041agcttagaac cccaagaagg gagcaccatg tagcaagact gaatcagaga ataagaaact
|
278101gtggaagtct ccagtcttaa atgttctctt tagagccaca ctttaaaaat aagaaaaaat
|
278161cagaactctg gcccctagct gtcctctctg tcctaatcca ccataataag agccagaaag
|
278221ttgttggctt gaaaggaatt tggggaatca aagtacatca ccatcataaa gacaaggaat
|
278281atgcggctcN aagttctgtg tcccagatca caagctagtt gcctgtagct ctggaagcgg
|
278341agctcaaggc ttgggattcc tctcccagag ctttttctcc tccattactc tgaagtcact
|
278401aaggctacaa aaaatcagcc actggtgaga aatgaacatg gaagaggaaa agaggttgag
|
278461acgggtttca tcaatagcag gtgaaagtgt gaggatggga aaaactttct ggtggagctt
|
278521ccaagtgcag atcattcaaa cagcagattt tcaaggtgaa taacaacaac taaaaaaaaa
|
278581ccttttatca gcaacctgag atgatcacag tccccagatt cagagaggga ggagagggtg
|
278641caaagKgggg attagacatg tgccagcatt gttccgcagg ctcagaactg aggcctggct
|
278701ggtgaggact caatgcgggc tatttgaacc ccattattag gagctctgaa cctaatcctc
|
278761tcacccctcc ctgcttccac acattgcccc taaattgtaa cctcttcagg gattctctcc
|
278821cttcccttgc cactgcctgc cacactaata ttcacaaaca cacagcctag aaattctcca
|
278881gtctgctcct cttccctctg ccccaccaac acctcctaac cactgctttt aaaactctaa
|
278941tgcaaatcac aggcttcaaa aaccttccct cagtgacagt tttacgatgc tagctccatt
|
279001catccatatg gtttgacaga cYgtgaaaca ccagtaaccg gaccaataag aaaaacaaat
|
279061tacaaaaaca ctRcaacacc tcatctctcc ccagtcactc aaacaactag aaaactttgg
|
279121aatttgcaat ggatcacaat atcagtctct cttgcagttc aacaacaatc tttgcagagt
|
279181tccataccac acagtggttt tacccactcc tccatcctcc ccctacccaa ggccactctc
|
279241catctttcct tgttaactac cttcatattt aaagactatt taaaattagg gccatgctta
|
279301caaattcccc tgttgggtcg tagctgggca aaaaatattt cagtggttgt gggatttttt
|
279361tggccagagg tttgcaacat ttggctacat ttctgttttc tagtgacttt caaaacactc
|
279421aaaaaccaca aaagttactt tgcagaggtt gggataataa acaggcctgg attctggtgc
|
279481ctctttatga cccagccccc atcgccacta ctgtcagcat agctgcctta gaaaactgaa
|
279541acatcagcct cagtttccat tctttttctg gtgcatgatc aaaacaaaac atgctgacca
|
279601tgacatttta ttttttgcat tgatctgaac agatggctct gaaacagctt tagacattat
|
279661ggtctttctc agatgtatcc aaattccagc tacctgcatg attccaaaaa gaggaggatg
|
279721agaggtctcc aactcagctg tctctgaatt caagcccacc ttatgtgact aagcagctcc
|
279781cattcaactg gcagtcttca atgtctcccg ggaggcctgc agaccaggct attttcagag
|
279841gtttaccctg tgacaatgcc tccacttggg ttctcgcaga cattaatctc catcataggt
|
279901gtctcatcaa aagcagacat ttacccattg aaaaataatg tgtgctaatg aggtttggag
|
279961aatttagggc ttttttatag tggcaaccag aagcagatgg agaacaggtt cttgggaatc
|
280021tgttggctta caacgtccga gggtcctttt tcataagaag ctaaaacaat gtccataaaa
|
280081ggcagcaagt tcacaaagtc ccggcctcaa tgctgtctac ttagtaccta cccacatccc
|
280141cccaacctcg acagaaagag ctaagaggag attagaacca ggaatgtgac ccccaccMct
|
280201tcccctctga tatctaaact gagtgccaca gcaagagtga ggtctggctt ctaactttca
|
280261catgcacaaa accactttag attagaatac actaatacag gtcatagaat gcacaaagag
|
280321atctagattt gacgttcatc tacacacatg acctgctgtt tgacttggct aagtaagttt
|
280381attttcttct cccagagtag tgttcttaac aacaaaacag ggacataaac acatacctcc
|
280441aagcaaggtt aactccttac aaaagaaagt ttcaatacaa tcacgtatat gtgtgtgttc
|
280501acagttataa gcatgacaaa atagtttatg ggtctcttta taaataatta cttaaggtaa
|
280561agccctgttg gttcatatgg aatttaataa taataatttt tttctaagta ggcaattata
|
280621ataatagaca tatatgtgta taatcaagtc tggcagaagg tggcagacat tctcagttaa
|
280681atgcatacca accaggattt tgataataca agagtaagtt gtttaaagta ctgattgcag
|
280741atttggggga aggtggttta tctgaactag aatattaaga ttcaaattta tattaaaagc
|
280801attatgtggc cagacatcgt ggctcactcc tataatccca gcactttggg aggccaaggc
|
280861aggcagatca cttgaggcca cgagtttgag accagctggc caagatggag aaaccccgtc
|
280921tccactaaaa aacacaaaaa ttagccaggt gtagtggtgc gcgcctgtaa tcccagctac
|
280981tctggaggct aaggcacaag aatcacttga acccaggagg cagaggttgc agtgagccaa
|
281041gatcctgctg ctgcactcca gcctgggcaa cagagcaaca ccctgtctca aaaaataatR
|
281101ataataataa taataataat agcattatgt ttcccaggta tgcaSaaatc aaccagaacg
|
281161tgactaatct acatgcaggc ctttatcaaa tccatattta tgttacctgc atgtgtttac
|
281221ttcactacct gggccttatc tcgcttgtat atgtaagaaa tgagggtaac tctcatacat
|
281281ctttgctcag acaatgtagc tgctaaatta aataatatgt aatacacatt tacacatcat
|
281341acatgtccac cagtgctttt gaattctatt tgtccagatg tgactgcttg gttgtggggg
|
281401ccacctgccg tgtccccttt gtgatctgat cagtgcaggc ggctcctatt tctgcctcta
|
281461acaccctgtt gggcagtaat aagatgttaa aggcgacaac agagagagaa gctgggctgt
|
281521cagcttcaga gaggaagggg gtgaagggta caacaaggaa gaaaaagaaa gggagttgag
|
281581gggagatcaa agacaggcag gaagaaagcc aaattgctaa gagaggagat gtggcttcag
|
281641gagcttggga ccctaaggaa aaccccaaag caatgagatt caaaattgtg ccatcccatc
|
281701accccagcta attgaattat tgaatgtccc acgtggaaaa agctagtaca gtgaaaaata
|
281761gcccatactc agcgtaggca gagccctgca taggtgctgc tggaaatctg agcttgtttc
|
281821ttcccaacac attaactacc accactttat ccccccatcc tgaggaaacc tttgtgtgac
|
281881cattttctgt aggagacgtc cgtggtgttg gctttttttt ttttggaggg aagagagaga
|
281941ctcagaacgc acacagagaa aatgctaatg tcgttcagct ctgtttcatt gtcaggaggg
|
282001acacatgagg ataaaaacat agctctccaa accattctcc ccgctacccc tcctccctgc
|
282061accaccacca tcccttcggc tggatgtgtc tctgcacttt gttctaattt atcccatgca
|
282121taatttattc acgtgtgtat tgtttcctga tcagcaactt ttaaaaacaa atgaaatata
|
282181taagatgttt tattaaacaa gttattttta aaaaaataaa ggcagatggt gtccctctcc
|
282241caataacaac gtgtgtgctc ctgcgttagg agttgtcaaa aactgtccag ggtgtgagag
|
282301gctgggctgg tcagtggtat tgtttatacc cctttactca cagggaaagg gtctgggaag
|
282361cagaaaggaa tagctaatta taaatgacca agcaactccc acctagaaaa agcaagcagg
|
282421ggcgttgtgt gtatgctagt gtctgcatgt gggtggcaac acaattacaa atacatcacg
|
282481ttgcaactgt ttctaattat acaaagtaca attcagaact aattccacta accggccaga
|
282541attccgccac cttctttccc gcgtctgtcc cttcccccac ccttaacccc accctacaca
|
282601gactccctcc ccaaacacgc accctactgt gatccaaaaa accctggagc gagtNgggga
|
282661acacaagctt agagatactg cgcccgcccg cgcgaaagcg ggctcccggg taactagggt
|
282721acggctttcc caggaggaaa caaacctggt gcacatgtga aataggttct ctaacttgag
|
282781tttaccaggt ggcatcagcc cggttatgtg atttcggctg gaaatgggga aactgMaaat
|
282841cagttgtggg ttcggtagaa acagcatcag cggtgttgca gcgaaagcaa ccggcagcga
|
282901ggatgcggcg aagttacgcc catttattct gccataaaac attttctttc ttgggtgaaa
|
282961cgctgtggcg ttcaagcgca gtgtatccga gcttccgagc cagaactgaa gccaggagct
|
283021cctatctgat cagcctcagc ttccaacgtc ctcttaacgg cagctttcat ataaatatat
|
283081ttgaaacctg gggccttcct acccctttcc ctatttctga tgggcgacga gctggcgcaa
|
283141acacgtccga ttctccctgt gcattccttt gcgttaggaa ccccctaccg tccccgggag
|
283201cgaacctggt tttcaactcc aggagtggcc aggggtgaag acgagaatgc gctgaattaa
|
283261aagaaccagg gtcgacagcg gccacgcacc agggagaatt cggcatgaac cgccccccac
|
283321ccgacctgca cctccctctg ccacttcgcc tgcggcttcg tccgggcggg gaagtcccgg
|
283381tcgaaggggt gaggaccccc cagcccacct cggatacgga gggagccacc ctctgccgac
|
283441atcacccaat agcacccctt tcagagcgac actagttttc cgaggccacc cctggctccg
|
283501cgatcgcgag cggacttggc ggcttaacag ttccacYgac tggaaggaag gaaggaagga
|
283561aggaaggaag gaaggaagga aggaaggaag gaaggaagga aggaaggaag gaaggaagga
|
283621aggatgaaaa ggaggaggaa ggcaggcagg cagaaattgg ctgttggacc cggggctggc
|
283681ccccgcgagt cctcgcccgg cccgccccac tctgtccagg atctgggcaa gcgctcaaag
|
283741tctccccgag gcggccagag gcacctgccc ctcgcccggc cgggagcaga cgctgccccc
|
283801tcgggccagg agccccaaaa ccgcctctcc gcctgcctca gcgcctcacc cagaggtggc
|
283861gagaacacca ttcataagac ctgcggcttc cctgcctcca aatccacccc aagttaaccc
|
283921gagtcgttaa tccactaaag ccagctcgct cgcaaataca cgagcagaca cacgcKcgat
|
283981cgcccggagc gcctccgaga tccgggggct gccggggaaa gcccggggcg accacctggg
|
284041ccccagcacg cccgggaccc gctgcttccc ccgcggtgct ccaactccgg aaggtttgca
|
284101caaactcccc gcgagcgatc ggaaggcgaa gagcgccctg caaactccRg agcctccgcg
|
284161gtccgtccgc tggacccagc ggacccagcg gcggggcggg ggccgcgggc tcgggggcgc
|
284221ggggctcggc caagtacacc gaggcggcca ctgcccgacg ctcgcccccc gcccagcagc
|
284281ccccgaagcc gcgctccctg cccgcgaggc gggggactcc ggggaccgcg ccgtccccga
|
284341gctcccgcga ccctcctgct gtagagcgct cgagcgccgg gcttctccgc ctgcaacccc
|
284401tatatctggc tctctctgca atttagcaga acacaaatgt aacaattttc ttcttgttaa
|
284461ttgcatctcc tgacatttct gcgcgttggg ggaaaaaaag aagatgaaga agtaagagct
|
284521gaaagaagag agaagccccg ccgcggctgg aggcgcctgc aagcgcaatg ctctggcagc
|
284581gctcgccacg cagaaggcgc cttttttttc atattgaaac cacgcggaat atgtacattt
|
284641tttagtctta cttacgcttt cagggggttg tgaatgacag tcgccatttt gctacaatgt
|
284701aacagaatat tgtctcagag ttctaaaggt tcgctcaggg gMagcgacgg gccaatcaca
|
284761gcgcgggata ccggcccgcc ggccaatcgg cgctgctggt agctaggtgg gcggggcctg
|
284821cgccgtggta gttattaggR gagctgtcaa agcccagagg tcactccctt ttgtagagcc
|
284881cgagagccag caggtcttaa aggggcagta cMgcgctggt agctcctttt cgggctgggg
|
284941aaagtggaga cgcacgggag agtattatag tttggtttaa ctccctactt ttctaaataa
|
285001ctgcagaaga gtttgcgctc ccggacagaa atatttaaat attgccagca agccactgaa
|
285061tcctattcat tagcctttgg ctttgcgtat Yaacattttt aatcccccaa agggtaaatc
|
285121cccgtgtttc agtgcaaaag ttggaaggct gccgtttcgt gttaacaaat tactacatgt
|
285181gctctgccgt ttgctaatgc tctgggtcct gccgcttttt aatattctta ttcccgaagt
|
285241gttctcttta tctcggccac cttcctctct cgcttcttgg aactgtcgct gctgttcctg
Following is a DPF3 genomic nucleotide sequence that includes the DPF3 SNP “DPF3-AA” (SEQ ID NO:).
|
AACGGCAGAGCACATGTAGTAATTTGTTAACACGAAACGGCAGCCTTCCAACTTTTGCACTGAAACACGGGGATTTACCCTTTGGG
GGATTAAAAATGTTGATACGCAAAGCCAAAGGCTAATGAATAGGATTCAGTGGCTTGCTGGCAATATTTAAATATTTCTGTCCGGG
AGCGCAAACTCTTCTGCAGTTATTTAGAAAAGTAGGGAGTTAAACCAAACTATAATACTCTCCCGTGCGTCTCCACTTTCCCCAGC
CCGAAAAGGAGCTACCAGCGCTGTACTGCCCCTTTAAGACCTGCTGGCTCTCGGGCTCTACAAAAGGGAGTGACCTCTGGGCTTTG
ACAGCTCTCCTAATAACTACCACGGCGCAGGCCCCGCCCACCTAGCTACCAGCAGCGCCGATTGGCCGGCGGGCCGGTATCCCGCG
CTGTGATTGGCCCGTCGCTTCCCCTGAG[C/A]GAACCTTTAGAACTCTGAGACAATATTCTGTTACATTGTAGCAAAATGGCGAC
TGTCATTCACAACCCCCTGAAAGCGTAAGTAAGACTAA
Following is a LOC145197 genomic nucleotide sequence (SEQ ID NO: 7).
|
>14:99854151-99949200
1tccgtgttgctgcgtgagtacaatctctctctctctctctcttttttttttttttttttt
|
61ttttttaaaaacagggtttcactctgtccccaagctggagtgcagtggtgcaatctaggc
|
121tcactgcagcctcgacctccacctcccccagctcaggtgattcccccaccttaatcttct
|
181gactagctgggaccgaccacaggcatgcaccaccacgctcagctMatttttgtattgttt
|
241ggtagagataagttctcgctatgtcacccagcctggtcttgaactcccgggctcaagcac
|
301acctccatccttggcctttcaaaggtctgggattacaggcatgagccactgcatctgcca
|
361cagtccccagtctgaatgcctccctctggtgggctggagctctgctccgagatggcatcg
|
421agtcatcctttctgcagaggttgacgacggggcacccgcgtggagcactgtgggtcactg
|
481tggcagaggccaggcagggccagcRgggctctggcactttgcgcagccaccgggaagtat
|
541ctggcatcacccccactcacattccacgaggcatagcaagcctagtagaataaacgtctc
|
601cttgcaaagatgactttcatctcccgtttcattccattttcctaacggagagaaagtaga
|
661gaaaggcaatcccactgtgtgtccaaagagagccagacatatttggtggccagtcctgaa
|
721gactggcacgttggacagcagctgtcctcgagtgaggaatgggacatgcatctagtcaac
|
781tacaccgcctgtgtcctttccactacgccgcagaaactgtgcagccgcactgctgttttt
|
841aattacaaagtttaagtcgtatgtattttaacactctttcaaaagttaaaagactgaggc
|
901ataaaacctcagtatctcttaatctatgccttgttttaatgaatgtctattgagtcctct
|
961cagagagaagttgctggagaatatacagtagcaccccattatctgtgggatacgttccaa
|
1021gacccctagtggatgcctgaaaccatggatagtcctgaaccctatatataaatatttgca
|
1081catatgtctatatctacacacatgcatatacatacatgtatatacaccatgttttttttt
|
1141tttcagtctgatcaccgagacagctactaagtgactaatggatgggttggatgagtggcg
|
1201tctacagagtgaatatgttggacaaagggatgattcgcacccggggtgagatggagcaag
|
1261atgcagcaagatggcacaagatttcatcatgctactcagactggcatgcaatgtaaacct
|
1321tatgaactacttatttctgaaatgttttcatttaatattttcagacctcggataaccaca
|
1381ggtgactgaaaccacagaaagcaaagccataggcaagagggggctactgcacggggcact
|
1441gggtgacatctgaaggtcagatcacacacagactttagtgtgagtgtgtcccaaatggtg
|
1501cagggagccgacttatacgaaaaaaattactcattacttatctgtcattcaaatttaact
|
1561agcatgctggggggagggtgtggtctgttggtttgtttttgctaaatctggcaaccctac
|
1621ctcaaagggggaggggctcattctaccaaacaatgcatcaaagcatgggttttgtaaaat
|
1681ttaaattataggaaaacgtttaaggcaaaaggtgctctaatctctgtaagggaggcagag
|
1741ctcattccctaataacactgcatgcacactcgaaggaagatgtagtgagataatttctgt
|
1801gttcatcccagctccttgcccaacatgcacccccaaagaactctggttggttggatctac
|
1861tgcacctgcttctgaagaaatctccaattttggtggacaccctccctctacattacccgc
|
1921ctgacctttcagaacccagcgggccgggtctcagcacattacctgggataaagaagacct
|
1981tgatatgtgttcattaagcaaaactgaattggaaggaagaaaacagagagggagggaagg
|
2041aaaaaaggaaggaagggagggagggaaggaaggggaagggagggagagagagagagaggg
|
2101gcatggagagaaggaagaaaagaaggaagtaggaagggaggaaagaaagggggaaagagg
|
2161gcagaagagaagaaaggaagggagggagggagaaaggaaagaaggaaggaaggaaagaaa
|
2221gaaggaagaagagagggagggagggaggaaaagagagggaaggaggaaagggagggagag
|
2281aggagaggagggagggaggaaaggaaggaaggaaagtgatagtatgggatcccattttga
|
2341ctggacatctctgaaaatgcccctgtatgctcaccaaggccctcaagaaggcactcaaca
|
2401aatgctaatcaatgaagcctgttccctttctcagagccaccatcagcccctacagcacct
|
2461gcatgggaatcaggacaggtgtccccttcaggtaagcacagctcccagatgcagaggtca
|
2521gtgagcggacaccacctgtggcttgtgccagttggaacacggccccctttcccctggaag
|
2581aagcaccgccaggtcccacagcctggccagcagagtaggaggctgcgccccagcccttgc
|
2641ctgcactcttcacatccgctccctgctcctgatggaaaggctaaagcattgggaagtgct
|
2701ctcagagctggactttcaccccttgtagaaaatgtcttctgcccagattacccacaccca
|
2761ccaaagagaggcagaattgaaagaaagagaggaaatctcccatcagcgcgtgcaggcaca
|
2821cccacgcacaccccagtgatcgccaggtgtgaactgtatgtaaggtaaacaattccactg
|
2881gagtggtgagtgaatggagctcatccaattcgatattttctagatggagcgaatggtgtc
|
2941tacattctcctcacttgtttttacttttttagccgtctacttggtgtttttggtgctgct
|
3001taaaaatgatttaaagaaacaaaaaaggcattagggggttgcacataatgaaatgaggac
|
3061gactgcaaccaaggctgacacttattctttagttaattcaattgtgcctaattatcttgt
|
3121tgctttgcaatccagcctctcccccaaccagcaagagcctccggaacattccttataatt
|
3181gcagagcagcccgagagctgagatgagtaatcctcagcgttctcattctctgtcctgtcc
|
3241ccgaatgcctctcaggatgtggaggagaaaacttcggaatccagatctttctctgagctt
|
3301tgtgaggagtctctgcctgcgtttccctcaggcgtcatcgtgaatggccggcagaccctg
|
3361tgcacgtagaatttcctgtctggctgtaggggaaaccactctgacagccaggcagagatg
|
3421aaataacccaactgaaaattaattaactccaaaacctccgcagaaaataaaacacaccaa
|
3481gacatatatgggccgcgagcaactttcagctttgggaagggatgggatgtgattattcaa
|
3541tttttctagtccttgactccaggttcttacacattttcttctgtgcctatgctgcgttct
|
3601gtaattagaaatttttccaacactctaaaacttcaaaattataccctaaagtcaagtttt
|
3661caacaaaagcaggacttctttggcttaccttcactgtaatttggtttgggaaagtgtggt
|
3721tttcagccatagcaaagaaaatggtcttcagaactcgaactgtctttagtgaaatgttat
|
3781ttttcaccaaatatgtgttcccacaaagtgttttctagcagctgggagaggtagccagct
|
3841gagctctgtgttgaaacgcatgccctgatacccccccgtgccccatcctgcagcgaattc
|
3901ttgggacccatgcttcttaggacctttggtcctcaagctatttagagatccatggaaact
|
3961gcccaatgaacaaggacaggaaacagggaaaggctgccgcagcggattcttcttcttctc
|
4021cttccccttccccttctccttctctttcctcttcctcttccctcctccctcttccctctt
|
4081ccctcttcttcttcgtgaatgagcgcactgatgaatagcagaggatgagaaccctgcagg
|
4141ccaggcacaggcagcatcaaagaaacagagggtggagcacaggtgcccagcccaggagat
|
4201ttaaaatcagatcagggacgggcgcgatggctcacgcctgtaatcccggcactttgggag
|
4261gctgaggtgggcggatcatgaggtcaggagatcgagaccatcctggctaacacggtgaaa
|
4321acccatctctactaaaaatacaaaaaaaaaaaaaaaaaatcagccgggcatggtggcggg
|
4381cacctgtagtcccagctacttgggaggctgaggcaggagaatggcgtgaacccgagagac
|
4441agagcttgcagtgagccgagattgtgccactgcactccagcctgggcgacagagcgagac
|
4501tctgtcaaaaaaataaaaaataaaaataaaaataaaatcatcagatcaggcagaccaaaa
|
4561ggccaagtcaggatattttgaagttgtaccccctcctcggacttcacctaatgctcccaa
|
4621tgtacacagaatgttctgtccctggatggaaggtgacccaaaatagagaagaatcatgga
|
4681aagacgaaggcggcagcctttttgccgccccacaacacctgacacccgagtgatgggtgt
|
4741ggccctcaagccaggaggcctgcgtttgggtcctggctctgccgcttaatggctgtgtga
|
4801tgctgagcaattacttagcctctccatgcctcagtttcctcccttgtaaatggatctaat
|
4861gaagacacctacttcccttactcttcgtcgtgggaaccaagtgaactaatgcatgcagca
|
4921tgctgaaccctgcagccgctgtggcgaaaacactcattgagatgcaagtctccacgcaac
|
4981agcaggtaaagccccattggaagtcatcgtttataatctcaattatttccttgacctaga
|
5041attgttcaatattaacagaaatgagatcagaattctttcagccaggcatggtgccccaag
|
5101agtgacagtcctgaagccactgctatttatggagccctttccacagaacacttccatgaa
|
5161gcacggttaYcattcccattcaYggaagaggaaactgaggcacaatgctgtcacgtaatt
|
5221tgcctacacagccagagagcaactgagccaagattcaagccctccgtctgtccacggcct
|
5281gccctctcagccactgtgcaatgctgactgcagaccagccacaactgttctgccagggct
|
5341ctgagtaaccggaacatggtgatttaatcaggaggagatatttgcagagatgttgaaatg
|
5401ggggacatccataagtgaaagcagtgatttgcaaaaataatctggctgctgctttcccaa
|
5461gcttcctcctatggaagcctcccctgtaacaccgagtggcacaccttctctgccctggcc
|
5521ggagccgagggcacagtccctgacagagctcagcacccacctccaagacacacagggaga
|
5581cagtcttggggtcagcgaatctgcacattccgccggcactcgcagggccagacaagctgc
|
5641tctggcccaatcttctcattctgtggtcgacacactgcggcccggagggagcagagggtg
|
5701gaatttcccagggtcaccctttggaaggatgccggagccagaccctggcctccccgaagg
|
5761aaaataaagcagtggccctgagccggggccacagagctccatgtggccggagcagggctg
|
5821cggtgggaaggggaaggatggagactggggcaccctcatcaccggttaaggggctctcct
|
5881gccaggcgcacgagacagaacattcatgatgctctgagacagaggaaagaaggtacggac
|
5941agcagggaagactctctgctcagccatctttccaacatattgtatttaaactatcaaatg
|
6001ctttagccaatctgcaaaaaataaattctttgcacaggggggtgaaatctggctctctcc
|
6061tcagcagaaggcccttctccacggctccccttggctcccacagaaaacacagggcagctt
|
6121ctgcagcttctccacaccatatatctagaatttacataatcacaggcaaataaaacgata
|
6181aaagcacactctttcataacaggcacattgttactattattattcttaaggcaaattagc
|
6241ttctgattatagagattagtcaaaaccatgattctgttgattgtgaggtagaactgattt
|
6301tcttttctttctttttttttttttttcaacaaggagaagagctgttgtttcgatgtcaga
|
6361aaattacataaaatggtactcagagagaaataaagtttctgaaagtcatttaattatcag
|
6421ttctcttggaagcgtttaggcattccagcctttcggttgttgtctgtctagccaaacatt
|
6481ttaccctcaagtttattaactgtttgattttattttatttaacctctttcttttaaaagt
|
6541ttctccaatttaaaataccaatattttagatatttgtatgtgtttattgggctttcttca
|
6601tcactgaaataattcatacctcttttgaaccaaagagatgcttgttctttcaccagcatt
|
6661tttgatcaaagacaaccaggaaggaagcatctcctccctgggcaaaatggaggatccaaa
|
6721accattaagagtctgctgcaagatgtcaccactcagactcagagagcttctggctcctca
|
6781gggcagcgccaggcaccagaggctccgtgaaagcccttggcaggagagcagcactcacRt
|
6841tgctcctccctgccccctacctgttttaatcattagtcctcagttaggtccagtgtctga
|
6901gccctgcctccagagttgagtcccgcctcctacctcacctgaactaactctgaggttcca
|
6961acctgggggtgattttgccctctaggggacatctcacaatgtgtggagatggtggRggtt
|
7021atcagaatagtggggaggtggtgggaagaggcagcgtttgagccacagggcagtcccacc
|
7081acaaagaatgatctggcccccaatgtcagtagggtccctgttgagaaaccctggtctaat
|
7141tgatcagaaatggtgggtgaactttgaacagataacaccagggagtcgtgcagctctagg
|
7201ggaatcctctcggaccctggagtgcccgatagaagcRgcgtgcacatggggactctgccc
|
7261agatccgagtccttttgtccatcatgatgtcccagattcctgctgtcattttgcatagaa
|
7321ttagactggaacatgcaaaaatatatacaattgttgataccaagatgtctgaatttagga
|
7381agaattcccaaacagaaagatccctcccccaaaatgtatgcatataaacttttaaggatg
|
7441cagataaaattgccagatgtctttcaatctgattacctcacatgctggcctgtatcccag
|
7501atgtgagatccagagaaacgtgatggaatgtgtcactgtcttcttttcacatcctctccc
|
7561agatttcattaatctgctgataggtactcattaaaatactagtattcgccctgggacaca
|
7621gtttcatgagattacttcacgaccgttacaggacatattacagtaaatgaattttccttc
|
7681ttttagcatggtggattaaaaaaatacataattttgtgccccagtcctcaaagaattaaa
|
7741catttcagcatatcttacgacaggatattggcaacgttttctgtaatgggtcagatagta
|
7801aatattttgggctttgcaggtcacgtggtctctgtcgcaactactcaacagtgctatggc
|
7861aggacagaagcagccatagatgatgtgtaaatgaacaagcttggctgcattccaataaaa
|
7921ctttatttacaaaaacaggctgtgggaaggacttggcccgcaaccctggtttgcctacct
|
7981ctgtcttacaacatagatttcctgaaaataatgcatctaggcagaaagaataggggaaag
|
8041ttcagagtaagacgttgtaaaatatcggcaagagttctcatcgtcttacaagaagtagcc
|
8101tgtgtacaacttaatatcaatccaaggaggaccaagaggcatgccgaaatgagatttaaa
|
8161ggttaaacagaaatctggagggaaaggaaRaattgcaaccacactggccaatgatctagt
|
8221gttgttactctcatttatttgctaagtttccctttcagtttaaagcacggcatttaattc
|
8281agacattgtccttcactccccatgagccaatgaaagaggagatgcgtgggctgtggaggg
|
8341gctgagatgcttgtggRcacctggggcagcggctgtgggctgtggtctcccgggctgtgc
|
8401aggtcaggaggtcaggaggtctctggagagaggcatcatcatggagctgggcctgctgga
|
8461gaaaggagttggccacggacaccccaaacaccccgatttgatcatgacactttctgtgca
|
8521tggaaccccacatgtaccccttaaaattttaccctgtaaaatattatgtatcaataSaag
|
8581agagcaccaaagcaatcatcctactagccaccatatgccatcctagcttctccacagtaa
|
8641cacgtcatttactcctcagagcggctcagcgaggtagggcctgctgatggtccctttcac
|
8701aggtgagaacacagaggccctgggaagctgaggggtttgctagagatcaggaagccagga
|
8761ctcgggcttgggtgctgggctctgggcctgtgtgtctgacttctccgagggggtgctgcc
|
8821ttctcctttcctctctttctccctaacccccccacactcagccactaagtatttttagaa
|
8881ttattactatttaggtatcatctataaaacatgacatttaccattttaaccatgttttca
|
8941tgtatactccagtggcatcaagtacattcacaccattgtgcaaccatccccaccacccat
|
9001ctccagagcccccattcaatagaaacccccccttctcccctcccccagctcctggccacc
|
9061accatcctgctttctgtctatgaatttgactgctcagggtgtctagagtggagtcctgca
|
9121gaatgagcccttttgggtagaggtgatttcattcagcacaatggcctcaaggttcactgg
|
9181tactgtagcgcgtgtcagggtttccttccagtttaaagtagaatcctctggttgtttgtc
|
9241cattactccatggacacctgggtggctgccacctgtgccctggtctctaagagctgctgg
|
9301cactctcgctcctccctggtccctttccttgctcacctgccctcccctggctcggctcct
|
9361cctcccaggcctccagcctgccttcccggcaccccacgcctgctgcctcgggaatcttgc
|
9421ccaaactccaatctgcttgggcctctcttactggtaaacccacaaggatccccaccttca
|
9481gcaaaaaagagttccaaaggctccatgtaggagcccaggcccctcactgactgccctggc
|
9541cagcctctccagtgttgccccaacggagccctgccctatgtacctacccttgttttcctg
|
9601aaaaccacactctttcctgcctggaggacacccttctcaccctggagagattacccttct
|
9661agaaacaaaccaaacacaccctctgcagaggctctgccagccgccttctccaggcaaggc
|
9721aggctgcctgcccccacgctcacggcagctctcctggcatacttgctgcctcggtttgtgc
|
9781aaaagcaaacctgcaagtcgcatacttaggggatggcccgggaagcccataaggatgtgg
|
9841gagaacaagacagggagggcaagaaggacaatcacagactcatcctggagcacattcaac
|
9901tgtgggacacaggaactcatccctgagactgcctggaatgtagctcggaactgtcccaac
|
9961agctcctaaccttccgaggttgatggtccctcctggttaactccgtggccagcaagaggt
|
10021cccaggaggccatcactgcacacagcaaccatccaccatgcctgcatgcaggtggcctct
|
10081gggtggaacagagggatgtgggcaaaaatctgggatgaccgcaagggcgccaggcacaca
|
10141gtgggtttgcgactgtggtatctgcctctcccacgggaggcagaccccatcaccaatttc
|
10201tctctgtacccccagcccatggcaggttggagacatctgaaaaaggtagcaaatgagtcc
|
10261atgagtggctgtgtgggaatgagatggactgggtcttgggagagaggaggcaggagtgga
|
10321tgttggaaagacaggctgctgagaggagaacacagtggcagggcaggtgagcagcggcca
|
10381ggggctccctcacacacttcaccccagcccctgcgccagcctcatctgcctgtctcccac
|
10441ctgacccttttgccgttcacctccgtcctctctctgctgggttctcaaggcaatcgcacc
|
10501ttgcctagcaactgttgctaccgaaagccaacgtccctggtattccaacaataaagcaca
|
10561gcgctccgactacaactcccagatattattgaaaagaaaggcaggtttatttcaaggcca
|
10621ggaggggagaggatctgcgtgttggaggctggagcagcagcgcattcgatggccggcctg
|
10681acagcatggcgagcagcttgtgctggtgcgtcctccagaaaaagaatgcgcgctctccag
|
10741gaggtgatggtccctgttcataaactccctgttgctccctgttcccattcagctgggtca
|
10801acatgtgcctgtaaattcctcccgaaagggaaatcataacagcatcagcagccccagaaa
|
10861tgacaaacaactcaagtatggaaagccagctgccaagtattcaacagtactcatgttgca
|
10921ccagaaacaaaaaaaatcagataagaaaaataaacccagttgtgtgcatagttccttaaa
|
10981tatgtatcccattttgtggttccttccagtcttcggtgtaatgaatatatccattggtta
|
11041ggggtcacggaatggcaggtcctaccaggctgccttggattggcgaactgtgatgttctg
|
11101ctttctcccttctctgaagcatggagcggtgcgagacgttcagaacagacagccactgac
|
11161attaattttcctgctggcctccttgctaaattgttttatgacttgtttgctgtgtcttgg
|
11221ttgccctattgtgttgagttgatttggcagtggttatttaaaacatgctttgtcatcctc
|
11281aggatgagtggaggatcccgggggtcacttttgcacaacaaatggtcattgagctgaaga
|
11341actgtcagagtcaccacctccacagtcaagtggcaatggaatccgaagacagggtcagct
|
11401cggtacaccacgagccgagatccacgggacggacggtgtgcaggcaccaaagcgtggaca
|
11461ggccatgctttgcttaacagcatggggctggccacggcaccagggcctctgccagcctca
|
11521cgaggcccctcctggcgtggccataaaagccacagctgcaaacgctgacacggcaagaaa
|
11581agaatatggtgagaaaccagcttttgcctttgcttctcagactcctcggaagatccgaag
|
11641ggcactttcccatccccaggaatgagaggccagattcctccatggtccagtcaggaaatg
|
11701taatcaagcatcaacgcggagccaggatctgtgcctcaaacttgaaacgtggccctatct
|
11761tcaagggtgctcacactcagatgacttaaaccaaaaatgacacggtgtggcctgcacttg
|
11821cccatgccatagtcaggaaagcctagtcaaggacaacgcaagcccagaggaagagggtct
|
11881aaacccagccgagaacagccacccagagcagaggccctcccctgagagaaagccacctgc
|
11941tctcagccatccctcttctttccctacgagctccaggagacagaaaccatgatgcttagg
|
12001tagacatcaatctgttatggcaggcaccagaatgtttcttctcctgtgtcccatcaggag
|
12061tcaaaactgatctcagcctgggcaatgtagcaagacctcatctctacaaaagataaaaag
|
12121gttagccgggtgtggtggggtgcgcctgtagtcccagctactctgggggctggggtggaa
|
12181ggatcgcttgagcctgggaggttgagactgcagtgagccgaaatcataccactgcactcc
|
12241agcctgagtgacagagcaagcccctgtctcaaaaaaaagaagaagaaaagtgatatctct
|
12301gctactgaggacaaacatcatgcaccctttcttcttaaagaggagcaaatttcccacttc
|
12361caagtcctgttagtgaaagtcccggaggagccccagcctgagccatagcaggagagtcgc
|
12421agagagatgaaagggtctgtccccagcccactgtggcctccagaggtagcatcttctgct
|
12481cagcagcagaacaaacatttccatggagcagctaagttgaaaagcccccaggaggcaagg
|
12541gtaggagttacaagaaaccagaaagtctacggcaaggtcagggtgactcgggtggggttt
|
12601ctcttgcttcccctttcaatagcattcatgaagtggctgaaagtcttcatcttgttatta
|
12661gctttgctttctggcctcgtttatctctaattgttttcctaagccttgaagaggaaattc
|
12721tgttttctttctggtcctgcttacatttaaatccacttaagtttctgtctgtggctttct
|
12781tctcaaaagggccaccggctccctgggggacaagcatcctccttataaagttgaagggaa
|
12841ctgggaagatcttgaaagacttctctattgttcatgcagacaagttgtgggaatttattt
|
12901ctgtgggtctgtttcctctttgttcagggggccccattcttctccaattatctgcctata
|
12961ccagagagtattttcagaatctgtgcaggatgttttagactgaataaggacaagcattga
|
13021gggaggttgatattttgctaataataacagtggaaaaaggtaccatttctgaagcaccta
|
13081ctgtgtgctggaaccttctgtgtgcatcacattttaaccctctcaactctccaggaatgt
|
13141attatgacacctactctatagattcaaaaactgaagggcagagatgtaaagaacttgcca
|
13201gagttaccagcagtgagagaaccaggggtcaaacccaagattgacccaagctcctgctga
|
13261ccccacgatttcacgtggcgcccagtgaaactgtaagcaaagcaccactccacaaatgcc
|
13321tcactcatctccacacccacctgacacagtcattggattttaggacacgcatccttcttt
|
13381caaagttcaggaatgttcacaagcaagtcaaaattcattttgaaagctcctttgacttga
|
13441ccgaagacgccccaagatgtcaccaaaagccaaggatgggaagccctgttctatcaaggt
|
13501gctgaaacccagtcctggggagtgtttgacttgggaagtaggctgccctccttctgctca
|
13561ccgtgggcagggaccagagagagggtctgggattcaatacgagcctgatgggggttctgc
|
13621catggggtgttggacgggggcgttcgacaaaccagtgcaggctcaaaccctgctcctctt
|
13681gcccccagccccaagagtcaccgagaaaacaaacacagtaagtctttcttaaacctccca
|
13741ccaagcaagggtgcaaaggaagaccatgggcctcagcgtgaatgcccacgcaccacagct
|
13801cttggcatgggtccccctgcctgccacatgttaccaccactcgctttgaagaacagcgtg
|
13861ttcatcagcactcacgaggcttaacagccacagtttaacctagtaatgcccagcccccac
|
13921agcaggctagtcatcatggtcagtgagaaacagccagacttttcacgcagatgggcattt
|
13981tcggggccagtctctgcactctccaagcaggagctggttggagtctctgcaggctcaggc
|
14041ccaagacgggtggccttcccagcagcttcgccatatcagctgccacgtgctataccgatg
|
14101tccttcgaggctcatcctaggacttcatcaaaaccgtttttgcagatgccaggactgtaa
|
14161tattcaccacttcccccaaccagcacatgaccttgatggagctggaatcagccagatcca
|
14221aacaaactgggcgcaacgtctgctctccagctgcactgtgcttggggtgcactcaggggt
|
14281ttgttcagctcccccgccaaagaattggagaagtcgtatttcacatataaatatatttta
|
14341cttctcagttcactaacatcagcctctcataaactcactaaatgaaaagctgcaagaatc
|
14401actttgttatggatatgtaaaatgacatattgcattggctaattatttctctatggaatg
|
14461aacagccccatgactttcaggggccccaaaagagaacgctctacaacagaagcacaaggt
|
14521cattctttagtgggcaggtaattgggaactccatgctaggctgtggcttattagggattt
|
14581gcggttcccctcaatgcacattaactgaaaagctggacagtatctagagcaggcgtgcct
|
14641tccatggcaacagcatctccgtcttcccagtgcatatggctgtcaaagtccttgtcaggt
|
14701accagttcagaaacacataacccatcctggtatttttgtagtttcacacatctagtggac
|
14761tacttgtttgcaataacatcatctggtgagcttttgaggatttgattctgtggcacttct
|
14821tgaggaatacattttttaatatcctttaatttttgcctaaggacttggctgaatccaagt
|
14881tagatccacatgtaacctttttaaggaaggctaaattgagacagaaaggccaagattttt
|
14941ctccgagtagaaatggatatttattacttaagaaattgcctaaatgttgctatcgaggct
|
15001ttataaagactcacttggtgtactggggaaaaaacacacaaagcaaaactagtccactga
|
15061ttctgtaccaattacaatgtttgccttaggtgaattgccaatctatgagtcatatttgtc
|
15121tatatcactctgcccagggtcaagagaagtgtctcaaataagcaggatgtggaaaagcgt
|
15181ttgatcacggtggcgatgccgaggtggggaaaattccagtgataacctctgaggaaaata
|
15241agccatttcttacaactaaatcctttctgtcatttctaaaatgaaaattaggagcttatc
|
15301aaaatgtaacatagcttaactatcaagatcaattagagatggaaataattgggtagctag
|
15361tgttctctacagaaagccagtgtgtaaggaaacagtagtgttatttgtaggaggcattta
|
15421attatttccaagttgtgggacaagtaataaacaagggtacatttctggctgtagaatttt
|
15481gatctataaatgtcctttgaggaatcagcttgttaggtgtattagtctgttctcacactg
|
15541ctgataaagacatacccgagattgagtaacttataaaggaaagacattaaatggactcac
|
15601acttccacgtggctggggaggcctcataatcatggcagaatgtgaatgagaagcaaagtc
|
15661aggtgtcacatggcggcaggcaagagagtttgtgcaggggaactcccctttgcaaaaccg
|
15721tcagaccttgtgagacttattcactatcacgagaacagcacaggaaagacccgctcctca
|
15781tgatttaattacctcccacgtggtccctgccaccacatatgggaattatgggagctacaa
|
15841ttcaagatgagatttaggtggggacacagccaaaccatatcattagcttttcaaagattg
|
15901tactttcaattatgatcaaggttccatcttagaaaaagaaagcaaatgaataaaataatg
|
15961gtcttaaaaccaaattccaaattttggttgcttcaaggYgtaaggtcttacaaaccatgt
|
16021ttggaacgatggtggatagttctttgatgactgacaaagagttataaatttcttctgtca
|
16081ccttacagtagaaggagaatcagaactgatttttttttccttcaaaaattccccgctggg
|
16141gacaatgacctcttccacagctttagtgtgcacactcatgtacaatttgaacaagcaagc
|
16201catgccttctaccccccagtggcatccctgcattcctcaacacaccaaagggatctggag
|
16261acaacaaaggggtcagcagatacaggtctttctataacttagtgatacgtgtaccaagat
|
16321agctgttttttcaggggaggaggaggatatttaagatattttaaacatctttttaaaaaa
|
16381ttggatggtaccaaaagatagagaattgtatcttccctatccctagagactcatgccttc
|
16441ttccagaatgtcatgttacctgattttctgtttgcaccgggttgaatagtaaccccaaaa
|
16501ttcatgtctatctggaatctcagaatgtgactttctctggcaatagggtctttgcagatg
|
16561caattagttcagatgaggttatagtgggttaggtcagaccccaaatccaatgactggagt
|
16621ccccataagtagaagagatagacacagggagacagaggcacagagggaagaaggtggcgt
|
16681gttagtggagccaaagaccagagctgtgaagctgaggagcactgaggcttgctggcaatg
|
16741ccggaaactgggtcgaggcgtcctcagggagcacagccctgctgatgccttgacttcaga
|
16801cttctggtctccagaactgtgacaatatccatttctgtcgtgttcagctcccagtttgtg
|
16861gtcatctgtcacggcagccctcggaacctaatccgctgctgaaaacatgccccttactga
|
16921tgtgctgaaccctattcccatatttggacaaagaaatggaatcatgtggcatgaccaaaa
|
16981ccatctgcatctttagcaggggcggcatcctaggctgcatgttaggatctcctggggttt
|
17041ttttaattttaaatcccactgcccaagctgcaccccaacccaattaaatcagaaactctg
|
17101gaggtagactcagacctgggtatttttaaccctccctgggtcattccagtgtgcagccaa
|
17161gaccgtgagaaccactgatctctaggatgcagcagcgtggttttctcacaaaaccactgg
|
17221cttcagagttagtcaagttttgggttaatttcttgttttgctacctcctagctgtgtcct
|
17281tgggcaagtcatttaatgtatctgatatttactttctcccatctgcaatgagattgtgag
|
17341gatccgtctttttaagcatgtaaaatatctgaaaatgcctggctcaaagtagacagcaaa
|
17401taaatgtcattttcttttcattctcccgacacatagagggacaatttcaaaggacatgta
|
17461agaatccaggctgtagagtgaggctgtgagaatcaaatcctgactccaccacctactagc
|
17521tgtaaaaccatgggaacttctcagtgcccagtttcctcacctataaaatggggcctcaga
|
17581gagccattatgaggtttacatgggataataaggtaatttgacccaggtaaagcacttaga
|
17641atagtacctggctcattgaagcattcattaaatgttagctcatattgtagatttacatta
|
17701tagacattatctgacaacactYtgcacagcccgcccccccttggaaatgtgaacttcatg
|
17761tggtacattttagcattgcttctcttcgccgtccagagcaacatgatatacacaaaagag
|
17821tcagtagacagcagtccggagacttgagctctgagctccgctgagatgccactaagcttc
|
17881aggatggaagacaacacttttctctatgcctcattccaggactcaaattataaaagaaag
|
17941ggtttactaagctgatccctatggttccttctagcatataaaagttatgatcatctgaat
|
18001attataaagcaatagatgaagtttgggctgtgtttagtaaacaatctctatgtttttatg
|
18061gttaggattttattctgaggctagaattcacacaaaaacgtccagtatcgacagagaagg
|
18121aatccaatccatttcattggaacaaagaacagccttagagatttttcaagaagtttcagg
|
18181ccgagtcacccagtctcccagtctaccgtataactgctggttgaagctggagagaagaca
|
18241ttagtggctcatgcacaaactttaaagcttaatttatgtgagaacataaattgatacaac
|
18301ctcactactatgagattaaataatatgtatcaatagtctaaacaatacacagtaattatg
|
18361tttctaggaatctctcctgaggaaatacaattaaagtgggaaattagataatagggatta
|
18421gtagtctacaatagtctaaactatacaaagtaattacatttctaagactcctgaggaaac
|
18481acaattaaagtatccttttttcatgcttttgggaccagcaattggagaatctgcccagct
|
18541caNtgaaaagccagttaaatagggaaatcttaaacaatggtgcaaatataccataaatac
|
18601gttgttataagttacaatataaaaatatgaattttctcaccagtcttgcaataaaggacc
|
18661aaggctcttctctgagtatcactcatgttctgattggaattatgtgccctctttcttgca
|
18721caaaacacgcctatataattcatgctcttaattttgagttttggtttctttaaagtggaa
|
18781cacaaacttaaatatttggaggacaatgtgacagtagacactttctccattttaccattt
|
18841tattttctcaaattgttcagtttcctggctcataatctagttttatagcaactgtattat
|
18901tacttcactttattgcatctccccaaagcattctacttagtttttatagtttatatggaa
|
18961gcaaccaccctctttcttttctcactcatatttcacaggttagtattccaaccaatgaca
|
19021tcacaacaactgtcataaacaggtttgagaacaaacacggtaattaactcttggtaagcc
|
19081catattccaaatagtgggagaaggaagactgaggcttcccgatgcaagcggcatatttac
|
19141cgaaggcatagaagacgtcagcgaatccagcaaaacaatgcagggaaacagtgattatga
|
19201gggttccttctgtagtcaaatatgtcatcaaaggtttatgtttaaagatgtttgaacatc
|
19261tggaatagtaactgatgctggcagaaatatagaaactatataagtttacaatgagaaaat
|
19321agctaagtaacataaaacatatgatgaaatggtatgtagacatcaaaaactgcattttaa
|
19381aaactattttatgatatagaagatgcccatattatgatctaatgtataattcaataaaga
|
19441tttaccaagcaatagaaaattttgtaaattctgaaaaaaaagtctattttctatctttct
|
19501tataaaaaccaaagtgggccaggacttggaaaacgggactgatgtcatgttgaactcctc
|
19561gcttcctttgaccttgatctatttggagtttaggcattgtttttaagaagaaaacatgcc
|
19621gcgcaggttctctaataataaaatgcacataacctcaagaaaaggtggggtcatttttct
|
19681tcttatatggccaagtaagcttctcctagaccttcctgcagataaccactatcaactttg
|
19741gataaaaatataaaataaggcttctgttcactagactgtgagtaaaaagcaggaagactc
|
19801tagcagcaagctagaggaaaaaaaatgccaagaggtgaaattcccatttttatagctttt
|
19861agcctgagggcatgtcaaagttgtcaccatgtaagtgagtgaatctctaaaagaaaacgt
|
19921tttgtttttctgggctgaagacaacagagttcagaacaactagggtcactggaggatgag
|
19981ggagtaattctggaaaagagacaagcacagaagaagcaccccaaattttctaagtgaaat
|
20041ctgaaccttatatgtgagaggtggattcaaagcagctaaactaagtgtaaaaaactgaac
|
20101taaaattcaaactgctccaggggaaagagttttcagtttgagtccaatcaaattaattat
|
20161ctgccctttgaaaaaatcagtgttcttccgagaaatataacagaatccagatggcattca
|
20221caatgtccaggatacgatccaaaattacacaacagaggagagacaagaaaatgacctatc
|
20281cacaagggaaaaataatagatgaagaccaattctaaaatgacccaaatgtaaaaattatt
|
20341aaacgagaatttaaaagtaaggacagaagtgaaaatatgttctccatgcctgtaaagatg
|
20401gaaagcatcatcagataaatagaaattataaaaaggaatcaaatgaaaattctagagcat
|
20461caaaatacatgtatgatattataatgttagacacatgtccttgtacatttgtccaaatcc
|
20521atataatgtacaacactgagaatgaaccttactgtaaactatggacttaggtgatagtga
|
20581tgtatcaatgtaggtttatcaattgtaattaaagtaccactgtggtgggagatgttgata
|
20641acagtggaaggtatacatgggggtggagggtgggcagggagtatatggaaaatctctcta
|
20701ttttgctctgaacgtaaaactactctaaaaagataagtattttcttaaaatgcaacttaa
|
20761aaaattcttcatatggacccaatagcagaatggatatgataaaagagtctgtgaacttga
|
20821atataggccaagagaacttactcaatctgaaaaatgtaaagaaaaaagattggaaaaaat
|
20881taacagagcctcacaaacccctgtgacaataccaacaatctactatcagtgtaaatggta
|
20941gaatggagggaaaagtgagaataggaaaagagggaaacattttgaaaaaataaggaccaa
|
21001aaagtttcccaaatttaatgaaagacataaatttacagataagaaagtcagaaagcctcg
|
21061agcagaaaactacagagaaaaccacacccaatcacccatagtcaaacagttccaaagcaa
|
21121agagaaagagaaaatcttgaaagcaactggagaaaaacaaaacataatggacagaagaac
|
21181accacatcaaatgacccagtttatcattacagaaggccagaatatactagaacaatatat
|
21241ttaaagttctaaatgaaaaactttaaaaacctattaacccagaatctgataccaaatgaa
|
21301catatccttcaaggattaagacaaaataaaaacaagttcatataagagatagctgacaaa
|
21361tcactgacagcagatctctacaggaagttctttattctgaagggaaatcatatcacatgg
|
21421aaattcagatcttctgcagaaaaggcaatctactggaaatggtgaatatataaaatacct
|
21481gggaagtatagaaaacttttcttcttgatttgtttaaaaatatgcacaactggccaggct
|
21541tggtggctcacgcctgtaatcccagcactttgggaggccaaggtaggcagatcacttgag
|
21601ctcaggagtttgagaccagcctgggtaacatggtgaaaMctcgtctctacaaaaaataca
|
21661aaaatttgctgggcatggtggcacaaacctgtagtcccagttactcgggaggctgaggca
|
21721ggaggatcgcttgagcccaggaggcagaggttgcagtgagccaaaatcacaccactgcac
|
21781tccagcctgggtgacagagtcagaccctgtctcaaaaataaaataaaataaaataatata
|
21841tatataaaattaaataaaataaaacaaaattttatattatataaataatataaaattata
|
21901ttttatattatataaataatataaaattatattttatattatataaataatataaaatta
|
21961tattttatattatataaataatataaaattatattttatattatataaataatataaaat
|
22021tatattttatattatataaataatataaaattatattttatattatataaataatataaa
|
22081attatattttatattatataaataatataaaattatattttatatataataaaataaaat
|
22141atatataaaatagcttatatatataaagctatttaagtgaaaattatagcattgtcgggt
|
22201tgggtttacactgtaaatgtaatgtgtacagtaactacagtatgaagtaaatggagataa
|
22261atgaagcaatgtagctgcaaagtttccacattttacatggtgagctacaatattaacact
|
22321aagtggactgtgataagttaaggaggcatattgtaatctttagagaaatcattaaaaata
|
22381cagaaataaatggcttaaaagtcaatagataaattaagctgaaattatttttaaaaatca
|
22441aataatttaaaaagaaggctgaagagaagactggaggaacaaaaaactacataggacaaa
|
22501aaagaaacaaacaaaaatggtagacctcaatccaaccatataaaaatactttaaatgagt
|
22561aaataattagaaggcagaactagaatagaaggaagaactagaatagaaatagaattttaa
|
22621aaggaaaaaatcctggacccatctataaaccgtctgtaagagaagcacatttttaaatat
|
22681aaagatacagataggttgaaagtaaatgagtggaaaaaatctacattattatatggaagc
|
22741ataagaaggctggagtgaatatgttaatatcagataaaataggcttcaagaattgcggcc
|
22801ggatgtggtggcttatgcctttagtcccagcactttgggaggctgaggtggatggatcac
|
22861ctgagatcaagagttcgagaccagcctggccaatatggtgaaaccccgtctctactaaaa
|
22921atacaaaaattagccaggcatggtggtgggtgcctgcaatcctagttacttgggaggctg
|
22981aagcaggagaactgaggaggcggaggttgcggtgagctgagatcatgccactgccatcca
|
23041gcctggctgacaagagcaaagctccatctcaaaaaattaaaaaaaaaaaaaaaagaattg
|
23101aatattttacagacaattacaccccaaacctggagaatatatttcttttcaaatgtacat
|
23161ggtatattcatcaatacataaaacataagacaagtctcactagaatcatatgaagtatgt
|
23221tctctgactacaaacgaattagaaatcaaacaacaataaaatatctagaaaatcccaaat
|
23281acttaaaaactaaacaacacacttctaaataatgtatgggtcaaagaataagtcacaaga
|
23341gaaatggggaaatatttgaacggaatgataataaaaacacataaaaatttgtggaattga
|
23401cctagatctgtgcttaggaagaaattaatagttttaaatgtttatatttgaaaagaagag
|
23461agatctaaaatcaagaatccaaggttccaactaaaggcactagaaaaagaggagcaaagg
|
23521aaactcacaaagttagtagacagaagtaaatactaaacataacagcaggaatcaatgcaa
|
23581ttagaaaacaaaaagtaccaaaaaatgtaatcaaaagcttgtttttgaaagataaatatg
|
23641agttgtatacctctagttattctgatcaataaaatagaaagggcacaaattaacaatatt
|
23701aagaatgacatgggagacatccctgcaggtgccatggatattaaagatatagtaaaagac
|
23761tatgctaactttaaattaacacattggacaacttagatgaaatggacaaattctttaaaa
|
23821cagaaaatctcaatactcatatatttatcaagaaattagcttctttatcaaaaacatctt
|
23881cacaaagaaaacttcagacccagatagctttattagttaattctatcaatacttaaggaa
|
23941ataataacaccaaccacataaaattcttcctaaaactagaggaggaaacctttcctaact
|
24001tgttttatgaggccacagaaaccctaaaatcaaagcctaacaaagatgttacaaaataaa
|
24061agaaaattataggccaatatcattcacgaacatagatgcaaaatgcttaacaaaatatta
|
24121gtaaacagaatacaatatgtaaaaaagatagtatatcatgatgaagtggggacatatccc
|
24181agaaatttaaggttaaattaacattcaaaaatcaatcagtgtaattcatattattaacag
|
24241acggaaagagacaaaccatatgatcatttcaacagatgcagaataaacatttaacaaaac
|
24301tccacattcatttatgagaaaaattagaaataacgttatacatagggctatcatatttaa
|
24361tgatgaaagatttcaacttctcctgttaagatacggaaaaaggcaaggatgcccacttcc
|
24421accattcttactcaacattgcactggaggttctagccagtacaataagatgacaaaagta
|
24481agtaaataaacaagtaaacaaagtcatccagagtaaaaaggaagaagtaaactgtatcta
|
24541tttttagataacataattgtttacatagaaaaatccaatagaatcaaccaaaccaccact
|
24601agaactaattcatgaatttagcagtttggtagaatctatccttctaccaaaggatagaag
|
24661gtaaacatgcaaaaatcaaatttatttaaaaaataaatttaaaaaataattccacttata
|
24721atactatcaaaaaacttaagatacatagggacMaatttaacaaaatatgttcaagactag
|
24781tactctgaaaattacaaaacattttggaagaaattatagaaggtataaataagtggagag
|
24841atataccataataatgggccagaagactaacatgtcaattctctccaaattgatctatag
|
24901attcaatgtgatcccaattttaacctgcacctgttttgtgggaattaatacgtttattcc
|
24961aaaaatctatatggaaatgcaatgaacctgcagctgcaccatacattatggtggccaata
|
25021actacatgtggctacttagatttctacgtaggttaatgcaaattaaataaaattaaaaat
|
25081taagttcctccaccacactaaccacatttcaagggctaaatactcacatgtgactagtga
|
25141ttactcttcttaaatggtgtagatgtgtaacatttttatcactgcagaaagttctgttgg
|
25201acagcactgacctcaaatagccaaagcaaccttgaaaaaaaccccaaaaacaaaaaacta
|
25261gaggacttacatacactacctgacttcaaaacatactacaaatctacagtggtccagaca
|
25321ttgtggaatcacatagacacaggagaaaatgttcaggacttaagaataggcaaaggttta
|
25381tttcacaagtcacatgaaacaaccataaaagtagaggtagacttcatcaaaattagaatc
|
25441ttctgctcatcaatagacattctaaggaaaatgaataggcaagccacagtctgagagaaa
|
25501atatttgtaaaacaagcatctgacatagcactagttcccaggaaacataaggaacccctc
|
25561caacccaaaaataaaagcataaataacccctctcctcaaaaaactggagtgagcaaaggt
|
25621tttaaaaagaaattttccaaaagaagatatgcaaatgttcaatatacacaacaaacagtt
|
25681ctcaacatcattagaaatcaggcatatgcaaattaatcaggcatatgcaaattaaaacca
|
25741caatgataataccactacacatctattcaaataactaaaattaaaaacaatgaaaacacc
|
25801aagtgttggtagggtgcagggcaactggaactctcatacattgttggtgagaatgtaaaa
|
25861tgatacagccactttggaaaaataccttgcagtttcctaaaaaactaatcacacacctgt
|
25921gacccagtaagtccacaactagatttctacttaaagaaaataaaaacatacactcattca
|
25981caaaaagacttatgcaaaagaaaatagcagatttattcataatggcctgaaattgtccct
|
26041gtgttctttaacagaaaaacagacgaacaattttttttattattatactttaaattctgg
|
26101ggtacatgtttaatatattcataaaacagaagaagatttagcaacaaaaaagaccaacta
|
26161ttaatacatggaacaagatggatagatctcaaaaatatgctgagtaaaagaagcaagacc
|
26221aaaaaaggggcatatactgtatggttccatttatatgaaattttagaaaaggcaaaacta
|
26281agctatacRgttagttagcagcgtcagaagaattgttgtctctggggatctgaggatggg
|
26341aacaacttgggaagtagcatgaggaaagtgtctaagtgatggtaatgttctacatctggc
|
26401taggctttggattgcagagtatgaacttgtcaaaattcagtatattcatttactactgtt
|
26461gcataacaaattaccacaaatgtagagacttaaaacagcacacatttattatctcatagt
|
26521ttttgttagtcagaagtccaaacacaacttccttgggtcctcttctcgggatctcacaag
|
26581cctgcaatcaacatgataaccaggctgtgttctcacttgaaggtttgactggggaaaaat
|
26641cttccaagttcattcaggttgtcagaagtcatttccttgcagctactaggctgaaggcac
|
26701tagcttttagctgggtatcatctggagaccatacttaggttctagagcccacagttccta
|
26761gaaagtgccctccatcctttgcaatccaggtttctcccagaaggccacttttttcaccaa
|
26821actcgcaaaagtctctggtcttgtctgctagcaagatggaggtgctgatggacagtgccc
|
26881ttagaccttctagaggtcctctggtttgattgagaggatctgggaggcatgccctcttaa
|
26941aagatacctttttgtgactaaatatgctcaccttttgatctttcagattttagcaaaggg
|
27001ttgcaaagtcacaccctctaatttttctctagaccacactgtcttaatttgagaatctat
|
27061tgccatctggagaggcttaaaattttcaaaatcatccagtcctagttcctttctgtttaM
|
27121gaattctcttgatttatctttctctcctctcacattttactgtaaacagccagaagagac
|
27181tgggatgccttcaacacttttcttggaactctcctttgctacataaccaagttcatcacc
|
27241tacaagttcaactttctacataactgcagacaacaatgttgctaagctttctgtcactgt
|
27301ttaacaaaggttctcccttctgtcagtttcccattacgcattcctcacttcctcctgagc
|
27361cctctcctgcagtgtccttaaagtccaggcttctattactatcagtcttttcaggaagac
|
27421ttaagctttctctattctactcccctgcccactgctgagtttcaaaaccacccaacgttt
|
27481tcagatatttattaacagccacaccccacttccaggtatcaacacttgtattagttttct
|
27541attgctgtgtgacaaattctcatagatgcatttatgatctcatagcttctttagagcagg
|
27601agtccaggtacgacttagctgcttccctgctcagaattccacaagtcttcactctcctct
|
27661gaaggctccactgggggagaatccatgctggagcctactcttacagttgttttgagaatt
|
27721atttccttgcagctgtatgacccaggaccccagcattttgctggctgttggttggaggct
|
27781aacctcaggttctgggggcaagacacagttccttgctacatgggcttttccaatatggtc
|
27841acttacttcatgaaggccacaaggagtctctagctccagcctaccagcaaaagggagtct
|
27901tacaaaatgttaacataaccataggagtgacatcccagcacctctgccatatgcatctgc
|
27961tactggttatgagcaagttataagggattacccaggatgtgagtatcatcaggggtcacc
|
28021ttaatgtatgtccaccgtactcagagaatgcacacttcagatttgggcattttacataaa
|
28081aaggaaaaggtagattggactctagatatgcatgctaaattgtttagggagaagtacacc
|
28141gaaatgcatcagtaaaaaagatgaattgatggaaggatagagggacagatagatgaataa
|
28201atatataatgacacaagtgtaataaaatgtcaatggaagaatctaggtgtgggtatctga
|
28261gtatttgctgaaaatttagttcaatatttctgtatatttaaaaattttataacaaaatat
|
28321tagaaaagtaaatgtatacttattaaaaagagcacagacataaatgagtcatctatttct
|
28381ttatacttttcagcattttctcactttactccaataatcatgaattttgtgtataatcaa
|
28441gagttgggggccgggcacggtggctcacacctataatcccagcactttgggaggccaagg
|
28501tgggcggatcacgaggtcaggagatcgagaccatcctggctaacacgatgaaaccctgtc
|
28561tctactaaaaaaaaaaatacaaaaaattagccgggcatggtggcgggcgcctgtagtgcc
|
28621agctactcgggaggctgaggcaggagaatggggcgaacctgggaggcagagcttgcagtg
|
28681agctgagattgcgccagtgcactccagcctgggggacagagcgagactctcaaaaaNaaa
|
28741aaaaaaagagttgggaaaatgcatttagtttataaagcagtcaatatatcaagccagcga
|
28801tctctccagtccattactgagtctttccctgctttcccatgaatcagtcaccaagagaac
|
28861agaaagttacccccacctccaaacattcttgaggttttctactagccagctgtggagtga
|
28921ttattcctctgttcacctaaacctctgaaattgcacatttttaggatgcattatctcttc
|
28981gacataacagttgcataatagtaccacaagttgcatacaattgctcttctatttatatat
|
29041tataaaactgcctccttaatattttagattctcccctctggttctaatatttttaaattt
|
29101ggtaaataaattgaaattcacgctaatcctagtgattcagattctaccataaaaatcaat
|
29161actatgtaaaactggagtgcttaaggctaaatcaacaacatatgtagtcatacctattag
|
29221tgtcctgcgtttgtaggtaaattaattagtattacttggaccacatcataccacagccaa
|
29281taaaaataacagatgtttggagaatgaagtaactggtgtatacaggcctagacattggct
|
29341tttttgtttttgctttttacaagagagaatggttctgtccagtcaagcacattattaagg
|
29401cattcatatttaataagtgggtcctaacataggaaggaaagttctaaggctacttattgg
|
29461cattaatatattatctatgctcccctcaaaattatttaatcaataagtatcagtcacctc
|
29521ctctgtgttaagtctattctagagaggatatagaaaaggagWgagagtaaatacacaaag
|
29581tcattagcaaagaatacaatacagtatctagctatgtgctaaaatcactaacagttcaat
|
29641acagcatttgttaggctagatactaagaaattagcaacagaatacaatcttcctcctgcc
|
29701ttaaagcactcctggttctctgcagaacagagctgagatgtaggacatcagtaaatcaga
|
29761cctagaaaagtcaaggggtttacagagatggcaggaattcgtgggaaagaaagccaagat
|
29821cttcaggatgggttggctttagacggcatcagtaaaaccaaggaccagccttcagtatca
|
29881tctttagttgtggggtaaaacaactgcaaccccaatgttactgcctgaggacttaacagt
|
29941taacctggctgccactgggatgggcaataagctcaaaccacagcatggagttttgggggg
|
30001accatgtctctcgggacctggccaatatgatgaggataaaggatgaataagtaaaccctc
|
30061aatgatgattctctcaaYactctcaaccagtgttctcagtgaaggttggggggcatcgtg
|
30121gaaagctagggggaaacgattttgctgatcacattatttgagaggtgctttttgaatttt
|
30181caactgtattcacctaaaataaatacatgataaactgcatatatttaagtgtactatatg
|
30241cttatttaagtgttttttccacacgcacacacagacacacacacacaacaaacctgcaag
|
30301accatggctacactgaagatgataaaaatattcctcactctccttcacaaaggtctcatg
|
30361cccacttgtgatgcttgcatgcccctcccctcttccatcatcctcaggcaaacattgatc
|
30421tgctgtccttatagattactttgcattttccagaatgtcatctaagtgaactcatattgt
|
30481atgtattctatttgtctggcttctttccctctgcataattatttcgagattcatctatgt
|
30541tgcagcacgtgttaatagtctatttctctttattggcgagtagtagtattccactgtctg
|
30601gatataccacagttattctattcatctgtgaataggcatttgagttgtttccagatattg
|
30661gcaattacaaataaagctgcaatgagcatttgtgtccaggtctttgtatggatgtatgtc
|
30721catacataaatcatacacaaatcatttctcttagatgaaatggaatggctcgcactgttt
|
30781tccaaagtgtcttactcatctcacaagcccacctacagagtttcagatgagccacatcct
|
30841tgccaacacttgctatggtcagtctttaatttatccatttcaactggtttaagtgctatc
|
30901tcactatgtttttaatttacagttccttaataactaatgacactgagcatcttttcctgc
|
30961ccttatttgtcatYcatatatcttctctggtgaagtgtctattcaaattgtttgcctaat
|
31021tcttttttttttttttactttaagttccaggatacatgtgcagaacatgcaggtttgtta
|
31081catagatagacatgtgccatgtggtttgctgcacccattgacccatcatctgggttccct
|
31141cccctcactccccatcccccaacaggccccggtgtgtgatgttcccctccctgtgtccat
|
31201gtgttcatattgttcaactacctcttatgagtgagaacatgctgtttggttttctgttcc
|
31261tgtgttagtttgctgaggatgatggcttccaacttcatccatgtccctgcaaagaacata
|
31321atctcattcctttttatggctgcatagtattccatggtgtatatgtaccacattttcttt
|
31381atccagtctatcattgattgggcatttgggttggttccatgtctttgctattgtaaatag
|
31441tgctgcaataaacataaatgtgcatgtgtcttttttttttttaagttggagtctcgctct
|
31501gtcacccaggctggagtgcagtggcacgatcttggctcactgcaYgctctgcctcctggg
|
31561ttcatgccattctcctgcctcagcctcccgtgtagctaggactacaggcgcctgccatca
|
31621cacccggctaattttttgtatttttagtagagacggggtttcattgtgttagccaggatg
|
31681gtctcgatctcctaacctcgtgatctgcctgcctcggcctcccaaaatgctgggattaca
|
31741ggcgtgagccactgcacccagcccacatgtgtctttatWgtagaatgatttatacccctt
|
31801tgggtttatacccagtaatgggattcctgggtcaaatggtatttctggttatagatcctt
|
31861gaggaatagccacactgtcttccatgatggttgaactaatttatattcccaccaaccgtt
|
31921ttaaaagcgttcctatttctccacagcttcaccagcatctattgtttcttggctttctaa
|
31981taattaccattctgaccggagtgagatggtatctcattgcggttttgatttgcatttctc
|
32041taatgatcagtgatgttgagctttttttcatctgtttgttagctgcataaatgtcttctt
|
32101ttgagaagtgtctgtttataatctttgcccactttttgatgggtttttttttcttgtaaa
|
32161tttgtgtaagttccttgtagattctggatatcagacctttgtcagatgggtagattgcaa
|
32221aaattttcttccgttctgttggttgcctgttcactctgatgctagtttcttttgctgtgc
|
32281agaagctctttagtttaattaggtcccatttgccaattttcacattttttgcaattgctt
|
32341ttggcattttcatcatgaagtctttacccatgcctatgtcctgaatggtattgcctaggt
|
32401tttcttctagggtttttatggtttggggttttacatttaagtctttaatccatcttgagt
|
32461taatttttgtataagatgtaagaaagaggtccagtttcagttttctacatatggtttgcc
|
32521taatttttaattaaattttttatcattgagatttagagttctttatacattctggataca
|
32581agtctttatcagatacataatttataaatattttctccagccttgtcattttcctaagaa
|
32641tatcttttgaagagcagaagtttttaattttgataaagttcaatttatcaatttgttatt
|
32701ttatggatcatattatggttgttctaactaagaaatatttgtctaacccaagtcataaag
|
32761gttttcttctataagttctacagctttagattttatattttggactagggtccattttga
|
32821attaatgttttttatatgcttagatcaaaagtcccagcacaaactgttgaaaagaatatt
|
32881cttcctccattgccttggggagttgtctgtataagtgtgggtttgtttctgaactttatt
|
32941ctgttccactgatatatttgtatattttaagccaatactgcacagggttgattaccatca
|
33001gtctatgataggtgttgaaatcaagtaatgctaatcatttttaaagttgttttggctatt
|
33061ttaggtcctttatagttccaaaggaattttagaatcagtctgtcgagtgctacaaaaaaa
|
33121aaaaaaaaaaaaatacttgctcggattttgatgaggattgtgttaaatccatatagcagc
|
33181tttgggagaactgacatgtgaatagtaagaacgcttcagatccatagacatactgtatgt
|
33241cttctccacttgacgtcttctttgatttatctcctcaatgttttgtatgtttcagtgcat
|
33301acaacttgcacatcttctgccaaatttatccttacatattttatattttggatgctgtta
|
33361taaatgatattcctgaatttcaatttatgatcttttttattcttaatatatagaaatgca
|
33421attgatagctgtgttttgattttgtataatgcaaccttgctaagctatttgttctggtag
|
33481cttttattgtagattcatataatttttcaagacaaccacatcatttgttcataaggtcag
|
33541ttttacttcttcttttcctatcaagttgtctttcgtttctttttcttgcctgattgtctt
|
33601ggctaggatctctggtatgataatgaatagaaataggaagagaacatatctgtgtcttgc
|
33661tcttgaccttagagtaaaaacattcagtctttgacacaagctaaagaatttatgtagatg
|
33721cccaatatcacactgaggaaatcccctcgattcctagtttgctgagagttgtttttagaa
|
33781atggatattggattttgctaaatatgtttttgggtaaagagaaggagggtgtctattgaa
|
33841atgaccacttggtttttctttctcagtttgttcatatagtgtgtatatgtgtatctacta
|
33901tacacatatgtatagtgtatctactatacaatgtagattgattttccaatgtaaagtcaa
|
33961cattgcattcctgacaaaccacacgtggtcataatgtgctatcgtttttgcatattgttt
|
34021cattcaatttgctaaaatttcatttagcatttttgtatccaYgtttataaaggacacttt
|
34081ctgtgattcccttttcttacaatgtctttgtcttattttggtattaggatagtactagcc
|
34141tcacagagtgagttgggaaaggttccttcctcttcaatttttaaaaaatgtttgtagaga
|
34201acaagtattatttctcccttagatgtttggtagaattcacctgtatagccatttggcttg
|
34261acatctcactgtgggaaagtctttaacaacaaattccatttctacagtagacatagtgtt
|
34321attcaggttatttaacttttaattggtaagcattgatgatttgtatctttcaaggtattt
|
34381gtccatttcatctaagttgcaaatttattggcataaaatttttcatatcattcccttatt
|
34441gtattataaataactggacaagctatagtgatatcacctttctcactttttttttttttt
|
34501tttttttttttttttggaaacaggttctcactctgtcacccaagctggagtgctgtagtg
|
34561caatcatagctcgctgcaggctcaacctcctagtctcaagcaatcctcctgccttagccc
|
34621cctgagtagctgagagtataggcacaggccaccacacctggctaattctttatttttaat
|
34681ttttttgtagagactggattttgcagagactgtgttgcccaggctggtcttggactcctg
|
34741ggctttagcaatcctccctccgaagcctcccaaagtgctgggatacaggcttgagccact
|
34801gctcccggccctttctcatttttgatactgKaatttgtttcttcttttttcctgatcaat
|
34861ctgtatagagttttatcaattttattgatttatttaaagaaccagSttttgggttcattt
|
34921gttttctctattgKctgKttttattttttcattgacagccactctggtcttttttatttc
|
34981ctttcttctacttactttgagtttactttgcccttcctttttatatttgttaatgtggaa
|
35041agcgagatctttcttttttcttaatataggcatttcatgcaacaaaattccgcttaagtg
|
35101ttcctctagcagcatcctacaaattctgatRtgtagtgtcttcattcagctgaacacgat
|
35161cccaatggtgggagctagaacaattggagcaacaaaacaaataacacagtattggcttac
|
35221agcccaaagcataagataaatatccatgagtctatcctgatagaaatagatgattgagta
|
35281aataactaaaggaggacagaagagctgagtctcccatgcagaacaactccaaatacttta
|
35341tgtagattctctgccagctaggagacagagcctagctccctgctcacgtgggagctgtgc
|
35401ctagagacttccatccaaagatgatggcattggaaaggggtaatgagtgactgtccagag
|
35461aagaaggctgacaaacactacgtccgtctggtgatgaaggtcaacattaaYggtgataag
|
35521ccatgttgatggtgggcacccttgggtgggatgtgatgagaatggattttatctctgtag
|
35581tcttccttccaaaacccgtaagcccatataatcacaagaaaaacatcagacaaatccgat
|
35641ctgtgggatattccacaaactacctgcccaggactcctcaaaactgtcagggtcctcaaa
|
35701aataaggRaagtcagagaaattgtcaaagccaagagaagctgagagagacatgatgactg
|
35761aacataacatggtgtcctggatcctaaagagagaaaactaaaacaacaggaataaagtat
|
35821ggactttagtttaaataatgtgctcatattggtgcattaattgtgatgagtatgccatac
|
35881tattgtgagatgttaatcttaggggaaactgggtgggggtagatgggaactctgtgctat
|
35941ttttgaaaattttctgtaaatctaaaactattctaaaatgcaagtttcttttcttttttt
|
36001tttttttttttttttttgaggtggagtcttgttctgtcacccaggctggaatgctgtggt
|
36061acgatcttggStcactgcaacctccacctcccaggttcaaatgattctcctgcctcagcc
|
36121tcccaagtagctgggattacaggcacccaccaccacgccgggctaatttttttattttta
|
36181gtgaagacggggtttcatcatgttggccaggctggtctcgaactcctgacctcgtgttct
|
36241gcctgcctcggcctcccaaagtgctgggattacaggtgtgagccaccgtgcccagccaca
|
36301agtttcatttttaaaaaaatctatgggatatgttgaaaagaaatataaggggaaaaataa
|
36361aaatttgagaattagaaagagacgtatatatttctaaaattattgacattaggtatcgtt
|
36421tcatttaagtagtcaatttaattgtgttatgtaacaactctttttaaaagtcaatattat
|
36481aatgtcaagacttatatattgaatcttatgatgaaactttcaaataacttgacaatgttg
|
36541caaaaggaacagagtttttcattccaaaaacatttaggaaatgaaagaaaagtcatttga
|
36601gtctagtggtagagaggacctgagagaagagattgcacactccaccccagttccccatgg
|
36661ccatttagacagggagagatggacatataagtgattcttacagctccctaaacttgtgtt
|
36721tgaaaactggagaagggataagaactctagtgttgctacctccctggacccctacctgga
|
36781tggagtactggtgaggcacgcatccaattcagctgatgatcccWtttttttttttttttt
|
36841ttttttttttttcagacagagtctcactctgacaccaggctggagtgcagtggcacgatc
|
36901tcggctcactgcaacctctgcctcccgggttcaagcaattctcctgactcagtctcccKa
|
36961gtagctggaattacaggcgtccaccaccacgcccatctaatttttgtatttttagtagag
|
37021acggggtttcaccatgttggccaggatggtctcgatctcttgacctcgtgatcctcccgc
|
37081ctcggcctcccaaagtgctgggattacaggcgtgagccaccgtgcccagcctgatgaccc
|
37141ctttcttaaggcttcctcagagacagccgagagccaggatgatgctgcataaacagccca
|
37201agagaactagtcaactcaggcaatcaaatgccaccattccagcagagattgccagcacta
|
37261gcatgaaactgaccaaaccagagttggaataagactacagagactccagcatctggggga
|
37321gccctggtctcttcWcgctgaaRagcctgaccactgcaacagtcctgtgtggctggaaat
|
37381ctgaggtctctggagaaggcttgaggaaaccacagaggctctctcggaatggcacgattg
|
37441cattttacgttttctgaatgtgtggggcacatatgctcttaataaaatattcatatctgg
|
37501aaaaaacctaagtaactgcctataaacatgtatctatctaaaggtactaaaaagaaatgt
|
37561ttttcaagttattaaggtgagccgatcctgcttacgttgttagttattaaagtaagttta
|
37621atttaaattttattatttttataccatatatattctatctgcaaaggaaaggtaacatca
|
37681gtgccagcaaaaccctgaacctcatttcacgattgactaacactcaaacactcaccacat
|
37741ccatagatgattctgtgcccctgttggcatcaggagctgtcctgtgccctgcaaggtgtt
|
37801tatcagtattcctggcttctacccactatacgcaagtagcacccgctccttgagtggtga
|
37861cacaaaaacatctccagacactgccaaatgtcctgcggggagcagaatcaccactggttg
|
37921agacccagggtctgaaaactacaaccgtagaaatccggctcactgcttgcttttgcaaat
|
37981aaagttttatcagaacacagccgtgcccattcatttctgttttgcctgtggtcccttcca
|
38041caccacagtggcagagctgagttcatgcaacagagacagtgtagcccacaaagtccaaac
|
38101tatttaccatctggcgccttatagaaaaagtttgccacccgtactctagtttctacctcc
|
38161taagtctcttctagatccatatttacctgtctcctgcctcgctgttgccacccagcccac
|
38221ccggatcaactgccacctggatttctgcaaaactcccagggcactcctgcctctggtctg
|
38281gctgcccttcagttcatgcttcacagagcatcctgggggacattttccgaaagcacaagg
|
38341ttcatcatgtcacttccctgtttaatgcctttgggtggcctcccctgtgcttaagataac
|
38401atgaggccccttcacatggcctgtgaaattcaaagattgaccccatcacattccagcctc
|
38461taaaaggtgtccatgagagacttccttctgtcctgcaagcagggaaYacaacaaaaccca
|
38521gctctgacctccagacacgaatattcccatggaMctgtgagcctgggtttaccctctgca
|
38581ccgtgtggcatggcatctcacctgcgacaggtgctccgccagaYgtcaaacagccacaca
|
38641gctgcccctgtgctgttagcttctcatacatattcagttaatgtgtcagYtactccactc
|
38701aaccccaacattaaccataggagactctaaaatttagtgtttgYtgaatagtctcYgcag
|
38761cagggattttccagttttttgataatgacccaaaataagaactgaatatacaaaacatcg
|
38821taatctagtacacacatgcttctgtgtgtgtgtgaacacatctgagacatacatttcatg
|
38881atagaatatttacctttaggccgggcacggtggctcacacctgtaatcccagcactttgg
|
38941gaggccgaggcgggtggatcacaaggtcaggagatcgagaccatcctggccaacatgatg
|
39001aaaccccatctctactaaaaatacaaaaattagctgggcatggtggcacgcacctgtagt
|
39061cccagctacttgggaggctgaggcaggagaatcgcgtgaacccgggaggcggaggtaaca
|
39121gtggccgctgcactccagcctgacaacagagcaagactccatctagaaaaaacagaaaaa
|
39181aagaatatttacctttactagtaatgttttttattgttttctatttcattgtttaaattt
|
39241tggtcacaactcactaaattacttcaattaacctactaatgtgttgtgatgtacagtttg
|
39301agaagcactgccctgcagcttctagcaaggtgacttgatgaattaactaagtgatgagct
|
39361ggttatgagaatatccaagaaacagttggaagggcctggatctttagctctgggtctttg
|
39421gactttccaatttgttagactttgtggcaaatgacccgatcctccctcacaaatgccgaa
|
39481tccctcaaaagggccccggcagaaagaggaatggatacaaaggtRctgttgcgagtgtgt
|
39541ttacccaaatccttgggctcctgcaaaaaccctgtggattgacaacttcaagggagccag
|
39601aaatgaccaaagattagctcaaagtaatcctccagaaaacgactgccaagagaggctaca
|
39661aatgtattcccccaaaaatgagaatacatggataaaagcagaaaaatttttaaaacttag
|
39721aatctgtaaaaaacagcgtggggcactgtgcattggttaccactgaatgcacggctgtag
|
39781ggatccggtgggctcaagtgggatctggtgggttccggtgggctctggtgggctccggtg
|
39841gggtgggcacaaggtaccaactaccttccatcctgctgaccttggctggccatctcaagt
|
39901taggcttaccccgctggccagcctaactcctgagcagtccccaagcttccctgccctgtc
|
39961cccttacacaccaagatttgactttataaattatcaactcacattccccaaatgaagcaa
|
40021acttaactttgacctgttagtagataccatatgcctcaaggtggtttgtaaacttgaatg
|
40081ggaaaaaaatttctacctttattttcaatactttctaacagacatttagaacacttgctt
|
40141caattataaacgtaggcaagaaacctcagtggtatttgctgttcctgtgactttgctgtc
|
40201aatagaaatcacaaatgttttcacacattaaagctgttgcaggtatctcgaaatatcact
|
40261cgcactcatcactactccgaaatcgtggtagttgttagatttataccactcgatcttatt
|
40321taagatattaataaagaagcacatatgaatatacatcacaaatgtggcttttgatatatt
|
40381gtcaccttatttcaatagaacaggtttcctttgtgactcttggtacttcattcatttaaa
|
40441aacattagtctgagaaagggtctgtaggcttcaccaggccacaaaacggcgaccgtgaaa
|
40501tgggtcacaacagaaaaaggaatctttgatgaatgcctccataggccaagcaatttgcaa
|
40561aaaaaattatttcttcttatttcagctactttattttttaatttttaaaaatatttattg
|
40621acttgtattctccaattcaaaaaataatttgatcttattataacaagtgaaacaatgcaa
|
40681gRaaaagatatacaaaggcagtctatcttggaagtttgatacacacatcacaatggactg
|
40741cataacaacatagattcaaataaagtgttaggaagccagctcagagaaagacagtgaggc
|
40801tggcaggtagaagaattgctagtgatggtgtttccattgtggaccaagtaagcagtcatt
|
40861cccataagatgtgagcaggcgccctgtgcaaaaggattctgtggtcacagtggatgagaa
|
40921aatgctcggttaatcaaaggcacactgcattttttttaatacactaaaatgcactgagaa
|
40981tctccaaaggagaaaatataatatgcaaggtttctgaaatacagttgtctacaaaatctt
|
41041cctctctcctccccaaccctccccaagaactttcttatattccccagaacatggtttggg
|
41101aattgctgaaacagggtaatgtaagtttcatcctgacctcagccatttaaaacatgcagc
|
41161caacaatggctacatcttttRtttttctctccttaggtcagtaaggagatatgagatttt
|
41221ttgtcttgccagaattctttatttatttacattaaaaacgagaaaaaatatataaccacc
|
41281aacaaaggtttcactcttttttttttgtactaatatacttcagactcagcttttaccttg
|
41341ctggagggagaacttaattacttacaggtttttctagaacagtccttagttcaaccctac
|
41401cacagtttacactScagcccacattacagaattccactggcatttggctctccagtctcc
|
41461ctctttagagtggtaatacagtgctctcagggttatacacagagaagtttagaaaatacc
|
41521agccagttgagactagttggcccctccactcagaaagctgcagaatgcctttcacccagc
|
41581cacaccaaaagatgtaaggagcaaagagctcccaccagccacgcacacaaaggacgtgta
|
41641tgctcacctggaaatcRgtggctaaagaggtagcacccttgcggggaccagaagggaccc
|
41701aaagaggcctgaggaaagtgaaggaaactagaaaagacagcagagtctcactcctataag
|
41761taaacttcaaacttgcttttaaaatgattagcaacacattctggtttgtttatagtctat
|
41821acatgatctcgcagagtcaagaaaagacagacttccctctgtaacctttccacttgcacc
|
41881aatgatttccagatcatcggtgcctgaagccaatcgcctgcttcaaagaggcatcctttg
|
41941caagagcacttgtgcgttcagagttccagtggtaccaaggatgacagtgaggcttttgat
|
42001agtgataggcggcttaatgaagagagccaggacagcatgcttgctctgcccccactcgtt
|
42061cacttgctccctaacagtgaatcgggggatggtctgaggctctccactccctaaccagag
|
42121cccactgagcccagactgccacctcgaaaatgggtgatgaccatcgtttccttgaccaga
|
42181caggcctcgacatcagcctttctatagaatgccagaaatggcagagcctgcccttgggcg
|
42241aaaacactttttagataactaatcagcaataatgctgcaactgacctgcctgcaggcttc
|
42301agcggctccagatctaaattaccctaatttttctcccccaaaattaggcataatattata
|
42361atttcaaggaacgcaagagccatttctcccatcattggataccaagctcaagatgttaca
|
42421ggaaaaagaaatagcttttactgctgatatgagaattttaaaagagagacaagtgtgagc
|
42481aaacaaaacctgtcacatcaaatactctggcaaaaaaaaaaaaaaaaaaaagctagaaaa
|
42541aaaatgccagaaatgctgaaatctaaataaagtcatttatttgttattttaaccccttca
|
42601ctgtcagagctactctggcataaggctagttaattctccagaggtgagctttattaagga
|
42661cagtgcccttattcttgcagccattgttttcttgtcacacagttctcttgattatctggt
|
42721cccttcaaggggttccacatacaaatggggtgctgttgatgctccttgggccgtacctcc
|
42781ttttaaagtatgattttttcagagaatttgattttatccaRtttccaccatgctaagcaa
|
42841aaacactagactgtgagatcccgaagggcagcagccccgtgaccctcatggttctggcac
|
42901atggaaggtattcaaagcatgagatggaaattgctttttgaactctgtgccttaggcagt
|
42961taacatgcaagcaaagataagatgccttcggcaggggaggctatgacaaccaacgagaaa
|
43021aatggaaaaacaccaattggatgggtctgcagttgatcacttgctcttccttggtcaagt
|
43081tcatgagcctgtctcctgtttcgaggatacatgcttttataaatgttaaataagctaaca
|
43141ctgctgaaagggcattgctaatggaggtctgtggaaatagagggaaatatttctaattag
|
43201aaggtatggattgggcactcactgtgtgccaagcactacagtggaccctgaaatgagtca
|
43261gccacagactcggtcctccaagatccccgctcctccagctccattcattttagcccgatg
|
43321caatgaggcttctttctgccttcaggaattgcttgggcaatggttcccaggaccttctga
|
43381ctcagaggattccacagacttttcagccctttcttctgggaggtctccgtggccttccca
|
43441ccactgcctcagtcttgtggtggtgccgctccccatgggggcttctcccaccctcccggc
|
43501tgctcctcccccacctcctgagcccacctctagaggctgggtcatctcgggctgttcctg
|
43561cggtctcttctgctctctaaatacccactgtccaggaacgcccaccctgcggtggcctca
|
43621gctcccacctacaagcccaggacttttctcccaagtcctaatcttattaaatatgctgcc
|
43681tgcctgcaggctgtattcaccagccatcttctcgccttcgcccaggagttgataccacca
|
43741ctgagagggcactgccaagcacctatgcagggaggcccgggtccctctgggccctgtccg
|
43801ggccacatcctcagcatttctctccgtctcaacagctcaagccctgtggtacctcttgct
|
43861gagcctctggggttctcccagaaggccagccccaccctcgtctgaccccacagtcctgcc
|
43921tctccagtgcggctagactgtcttccccagctgacgcccatctgcggttccccacggcca
|
43981gtctcaacagtctcctgcctgcacccactcctcagccttctccattggaggctcccctcc
|
44041tcagacacacaggcctgtctgctgccccatcgtctctgcgcaggctgctctctcggtgtc
|
44101cctggcccatgcccactccacgctccagggctcagcctcctctcccgctctccaccccac
|
44161ccttcgtctcctgccctccaccccacccctcctttcccgccctccaccacacccctcctc
|
44221tcgggctcctgggcacccccccgccacctgcgtctcctgtcgtcagcaaaatgcactatt
|
44281tgctcatccagtgcccacagtttgcccaccggacggccctgctaggtgggaagctccttg
|
44341caggcaggaaccccatctccttgactttactttggaatccccgcagcctcatacggggct
|
44401gaggcaggtccttccgtaaaatggaactgaatgagcggcgcttaatccatccgccaaagg
|
44461ccagtctcccttgggttttcaacaggtaacatgagcttttaaaaatgagtcttgttaaat
|
44521gaagtgccctgattttcaaagttatgcccacacagaacgacagggcaggggctcccttcc
|
44581agaatgacagagccctggggctcgtctgaccacttctccacccccagattcctctcatca
|
44641cccgatgcctttactttgggactcttccaggtcgttcctcacctcgtgcagcattgctgt
|
44701gagtgggcgacaaggaacctcgtggtctccgtgtgctttgcggggaccacctcttcgcag
|
44761gggccgccacctgcctctccggcgctgcatccttagcatccccactgcccccggatctcc
|
44821ttcagggaggtgcggcggcagagcggccccagcagcctcctcctgtggcccaggcgcacc
|
44881aaggcgagcgcggccacgagttccggcccagcgccacccagactctttgatgtgggtttg
|
44941tgtgtgggagagtaaaagatgcacacaccctccgcaagtctagaatttgtggtttttgtt
|
45001atctcacaacttcatatttggaagaagtattttaatgtcttatgagttgtgaataattat
|
45061gtaattctgccactttctcaaaaccaagatttttcaaacggactgctctagtctggagct
|
45121gacatccttaagagaactttgctttttttcctgtgggttttaagcaagagtgtgccaaat
|
45181gaattctttcgtccgcttaaaacagttcattagggggaaccatcctgtaaaaggaaagga
|
45241aaggaaaggaaaatccttccttcttcaaatgaattctcaaaaattacttctgagatgcaa
|
45301atgctgcctgagtgtttgagctccgtgagagagtccacttcccaacttgttttcagtctg
|
45361ctgttgggtgctactgaatttcttaaacattgtgtttctcccttatctgtgaattagcca
|
45421tgtgttctttggaatctcttcctgggtcttcgttattcttcctcagttatttaaRaacct
|
45481agggaaggcccggcgtggtggctcacgcctgtaatcccagtactttgggaggccgaagcg
|
45541ggcggatcacctgaggccgggagtttgagaccggcctgaccgacatggagaatctaaaaa
|
45601tgcaaaattaSccgggcgtggtggcgggcgcctgtaatcccagctactcgggagactgag
|
45661gcaagagaatcgcttaaacctgggaggcggaggttgcagtgagccgagattgcgccattg
|
45721cattccagcctgggcaacaagagcgagactccgttaaaaaaaNaaaaaaaagaaaagaaa
|
45781aagaaaaaaccctagggaaagggtcacgaagactgcatcatcaaatgacaccatgaactc
|
45841ctcaagggtctacccattgttttaacttactgcccaaaaggtacttctcattcgaatagc
|
45901ccccattctacagtcatctctatcaatcatcatgtcacttgatcatgacatcgttctaag
|
45961cacctgtaacatcccagaccctgtctgaagcaccaggaatgctgggtgagcgggacagaa
|
46021gggaccacagatcctcaYgttgccttatcaagtttagactctagtggtcccgatggctga
|
46081tctcatgacattcaaataggaggcgatcatttccttaaatacaaacacgagattgtcaat
|
46141agttaggatgtgcttatttttcctccagggcataagattttttttcttgtatgtatttca
|
46201tatccctagctggagaaatatcaaaagaatctgaatatcaccatctggaagttgtgccat
|
46261ggactccagtgggcaggattcgagctgggattctcttcttcctctagcagtgtatttctt
|
46321ctgcttaaaatgagcacaaacacRtctaattccctaatggaccaactcagacctaaaagt
|
46381ctcttattctttgcccgccttcctctacccacatggattcctgggattctctaaatgcag
|
46441atggcaatggggagggctggggattcccatcaaggatatttgatcatcggtgacttcact
|
46501taaccaataaatcaaacgtgttgaaatacacacatgtcagaaatgtggtatgctgttact
|
46561cactcaaaagtctgttggtctgtcttggttgcgattgggcaatgaagccctagggactta
|
46621tttcggcttcaatagtctgtaaccctcaatcaatatttcgttaagtgtYagtattcattc
|
46681ctagtatttccccaagtttaacttgttccttttgaaacgactggtattcttatgagccag
|
46741aagactgttatttgaaaatgtttccttttttttttttttttttttttttttttttttttt
|
46801gagacggagtttcactcttgttgcccaggctggagtgcagtggcacgatctcggctcatt
|
46861gcaacctccatctcccaggttcaagtgattctcctgcctcagcctcccgagtggctggga
|
46921ttataSgcacccgccaccatgcccagctaatttttgtatttttagtacagacggggtttc
|
46981accatgctggccaggctggtctcgaactcctgacctcaggtgatctgcccgccttggcct
|
47041cccaaagtgctggcattacaggcgtgaaYcaccatgcccggccaatgtttccttttttaa
|
47101accttcattatatatcactttcacatttagaactctcttcgcctccatctagaaatattt
|
47161tcgttttctctggatgtgcttctgtctcccgctggacaagcctggcactccgggaagagg
|
47221accctgtgtatcacgacacctggcacacagaagaagctcaataggcactgaatgattttt
|
47281ttttaacattgaRgttgtttttagctctcccctattagccgttagttagcagttcacatt
|
47341gtatgtggagtctgtatttataatataacattagttctgccctaaaattccacaggacaa
|
47401attccatttggaaacgtcctctaattgtcatgcagtggttctgttcaaactgcgggaaca
|
47461tttctaaatcccacagctctaacaggctgcctgcccattacagaaggagacttcaggcgg
|
47521aaattcaaaacacttgctactgtgacatctgcccagcagtactaatttacatccatttgt
|
47581atttattattgtatagtttggRatgtaataagatgctgccatcacccccacaagcctctg
|
47641gaatactgaggagtggtattgcatgtcatgaagcacgcaggctcttcgagtttgacctct
|
47701gctttgaattcccacttgacccaggatgaggaagtctgactgagcagcggtttcctcatc
|
47761tgtaaaatgggtataacaccagcacctatcttgctggattggcacctggaataaatgaga
|
47821aagcacaggccaagccctccagcattggacacagtcagcatgtaattaatgctagctctt
|
47881cttattaaattcctttagcttaaagacaaagtaatcagagacacttacagaattacagaa
|
47941gagtttatcatgccgttctctttgaggaaaacagttaagcagttttaatccattttataa
|
48001taatgtcttacataatccttactcagagctttaatcaaaaaggttgtcttttaataaaca
|
48061agattcacatttagactctgtctacacacacaagccagttttaaatgtcacccagattaa
|
48121gtcaaacaaccgataattaacaatgttttacatgtaactggttttgtttgtggacccagt
|
48181cctaaacatttttttaccaagtaaccttaaatatgtcatcagatgggtttttagtagaca
|
48241tatctgaacctaattttgtagcttaaaaatagtatattttattcactttttttaatatta
|
48301aatatgtaggatattttaatacttggccaattcaagtgttgataagtaacatctgtcaac
|
48361atttacaatattatctagctcagttatccagaataaactgagaatcttctggatttttaa
|
48421aacaattctcaggccctgatttactaggagagtttgggaggacctttatgcagacaaaca
|
48481actcatagtttaagttggcttccgctcctttctaacacaaagataaccgcgaggtggaaa
|
48541aatatcactttgtgaaaacgacatcttagcaaaacagatctgtacaaggcagaactggac
|
48601aaaatatgttgattcacattaccactgacttatatcagacattctatcattttatctgcc
|
48661tcgagcatttatcaaagtaaactgctgcagagtgcaactgcctccttgtcggccgggaca
|
48721ggtgttaccacatctatcgcctcgcctgcttgtaaatggggatagcccgttcctacagct
|
48781aatcctggcaacacaagctcaccttcacacagcaggattgggaggctctggaaggttcta
|
48841aggccaaagacagagccaggtctgcttggaagccatctgtgatccccgttcctacccctc
|
48901caccttgctcatgcctccctctgcagcgaccagcctggcaccaaaacagcacctgccagg
|
48961ggaacttgaggatttggctggcctggggctagagctgtccattcccaccaagaggaagag
|
49021gcccacaaccccagtggcctctgaggccagcagagcctgtggtgccacaagggaacagcc
|
49081tgtgagcctgtcctccactgcgccctgcgcttctgactcagactaacacaccaggatttt
|
49141ccatttcaacagcagtgtctgtggtcctcttttctaagtgaaagagtccaagctaaggtt
|
49201ggctagagggatccttgcagctccggagcaggtgtagggctgataccagccctctgctgt
|
49261tatttgacagcttgcaaaatgtacaaactggccagatacaggtgtgtgcttgcatgtgtg
|
49321tgcatacacacacatatctgaatatatatgtgtgtgtatctacacatcatactaataaac
|
49381taataacttccatgggcaataaattttcaaatttcttaaggattcagataaggagaatgt
|
49441atataatcaacacattaattattatgcatacataaacatactaatactcttaatacgccc
|
49501tttgaaaaaatatattcaaccagcttaatttttctaattttgtttttgttaaatcctgtt
|
49561ttcttattaactattgattgctaagcagcaggcagtgtgctaagtatgttacctggatta
|
49621tctggttaatccttccaatagctacacggtgaagacacagatgtccacatcttctgcaga
|
49681taaggaaactgaggggtaataataaataatttgcacaacacagcacaaagctgaggagcc
|
49741aacactggacctgacgaagtcccattctggaagccaaactcccaactgctaagctctgct
|
49801tgaattctcattgagcatctYgcttcttaaaagtttcaacaactcagcagtctataatcc
|
49861aactcgccttctccRcaatgccaaaaggtagaagtgacactttcttttttttctttcttt
|
49921tttttttttttttttgagacagagtctcattctgtcacccaggctggaatgcagtggcgc
|
49981gatctcagctcactgcaacctctgcctcctgggttcaagcgattctcctacctcagcctc
|
50041ccaagtagctggggctacaggcacacaccaccacacctagctaatttttgtatttttagt
|
50101aaagagggggtttcatcatgttggccaggatggtctcaatctcttgaccttgtgatccac
|
50161ccgcctcggcctccgaaagtgctgggattacaggcatgaaccaccaagcctggcagtgct
|
50221ttcttataagggaggtgctttccctatccatgagggtatttagggaaccatataaaaata
|
50281tatatgtaagttgtataatggtaattgatagacataacacagttagttaaaaatggcgtc
|
50341aaacaatagaataactactttccatccttcatagattcaatactcatttagctgaggttt
|
50401atcattggccaacatcagggttgagctctgggagggagaataaaaagtagtaggcaccct
|
50461cttctccccaagaactcacactgatcatacagataagatgtgtgtggtataacacttgct
|
50521ttccatgaaaataaattgattaatcacatcgaaaatagaggaacaaataatgaaagtgtt
|
50581tcttagggcaaaaaataagagcgctgggggttttcataccctaaaggtagtcctttttct
|
50641aacaaccaaagaattggccatgtctactcctgacatatagccgtcctcctttgctaccag
|
50701gaataaacaacaatttgactgagccaaatagcagatgcaattttgcatgaagctagtaat
|
50761actgtttatgctttactatttttaatatgctataaaaactatttgtcttttcaaaaaaaa
|
50821attttttttacagatttaatgccactgccttaactttaaaccaatggggtagacatttct
|
50881ccttctcttttcaggggcaaattttggaattattttaaaatcagtctgatgcctcacaca
|
50941tcacggctgctaaacttgggtatttgtttttcagtgcaatgagcttcatgctgaatactg
|
51001atttgaagtgtggttcaccacacagacttaaattgtccttcccacaactttatctgagaa
|
51061gcatgacaacggtgacaatcacaggactagttttattgggtaagactattctatgtgcaa
|
51121tttattctgacaggctccacaatttttaagtgcaattaaatcctaagaatttgcccaNaN
|
51181aaaaaaaagtctaccactttttaaaaaaaattttttttgaagaaagcagaaaaaacagtt
|
51241gaattgaacaactaattactaactggttgctctcttgaaaaaaaaaaaaagatatttgac
|
51301agagcctcaaaatcgatttcattatctagacaggcaactttctgggtctgagaaagagaa
|
51361ggcttccaggaggtctgcagccacctgcttcagccactgctggtatccacatcttcaaag
|
51421cggaggtttagccacacccagaggggggaataacacttgcagaaaacaacgctcagaaat
|
51481tggcgtcacctgattccccacagcagagcagaccagctgtctcctgtacaggtggaagca
|
51541gcttgcacgcttcctgccatccgcatgctcactcctccctcacagtcccagaaatggaat
|
51601cccaagaggccgctcaggcaagccagatagagccacccatgtgatcaagcattcagggca
|
51661tgagggcccccactaccatggcccggaaaatacatgcatcaacatgactcatgtcatttg
|
51721cttgcccttggtgaatttcacgttgcatttctaacccgaagctagggtcgcRattgtctg
|
51781gggcgtagagtccctaccacttctaggtattccacattcccagtctctattcaacaagag
|
51841gctaggctgacactgaagcagctatccaggttattcttcagaaatcagatatttttaaag
|
51901tgatgccaagtKacacctaacatcatagaatattctcttcatgtgaacttaattcagtag
|
51961aaaacatcttcggccagacacctgcagctggcataatctggctatctggtgcctgctgct
|
52021ccctctacccttgctgctgccccgacctgccccataccccagcccccattggggtcgacg
|
52081gtttcccagagatactcagccttttggtgctcctctctcctcctggtataccccatgcat
|
52141taagcattgatcctcccatcttgtgtgcccccaagacatctaccactgttaacactaaaa
|
52201tggccttgcctgtctcacccaatttggctccgaactcattgaggaccacctYacacactc
|
52261cccagcacctcacacagttactggtacagagcaRgctcccggggatgtttgctgaaRgtc
|
52321tttttttcccttctgagctgctaaaacaacaggcattaaacagtcacctgggccacattg
|
52381ttgctgtgaaatgtccttctctgcagatcgtaagccccgtgacgtgatggcagaaaccgc
|
52441gccctccttttgtgccctaatacctgggccagtgctctgggcctattagatgccaataaa
|
52501tgtttcttgaataaatgaattaaagacaatactgatacagacatcctgagagaaagccga
|
52561aaaggtctaaaaatgaaggcattccaacatccatgtgcacagaacattgggaaagctgtc
|
52621catcagcgtctctcttttgtgacttcctattaaggtgctccgcagaacttgaactgacct
|
52681attgcagtacagcacagtactagggacacaggccaggtggaaagagattacttcatctgc
|
52741ttgccatgcaaagcagggctgaggatccgaggcctcaacatggagagtgggaccccaggg
|
52801ccctcacccctcccttctcaggccatttgttcctttttcctggatgaccacctcccacct
|
52861gtcaccccctgcctttgccttccacttggccaatgctaaatcaccctctcagactcatct
|
52921caggtaccacctctccaaggacgcgttccctgacccctctgggcctggcctggtgtgaat
|
52981gcatactatactgttaccctcactggacagagacactctcttcctttttttttttttttc
|
53041agacagggcctcactctgtcgcccaggctggcgtgcagtggtgcgaacctccacctccca
|
53101ggttcaagtgattctcctgcctcagcctcccaagtagctgggactataggtgtgctgcca
|
53161ccacatccagctaatttttgtatttttagtagagacagggttcctctatgttggccaggc
|
53221tggtcttgaactcctgacctcatgtgatcctcccacctcagcctcccaaagtgctaagat
|
53281tacaggtgtgagcagccacgccaggcctggtcacttcctttctgagtatctccaccgcta
|
53341ctgagtgaggaccttgagcagtgccaggatttgctgttgctcctgcctcccaccctctct
|
53401tgaatcctgctccctttccccctgcctgggcctttgccacttccccagattttaattatg
|
53461caaaattaaatagctgcttcataggcgaacagctggatacaacaccttgcagtcttcagg
|
53521ggaaatggtgcaagcataaaaaacaggaagagcaatttaagattaaaatactgctttgag
|
53581gctggtgtgggcactgtctccaacagaggctgacacttgcctgctggatttaaacctgcc
|
53641catggtcaggcatcaagccccccatgccaggcctaggggagacagaggaggtgagatggc
|
53701cacaccctcagccacctttcctactacttttggcagctccacgattggcaccagaatggc
|
53761acttattggagggttttctccctcgcagccctcctaagaatcgcctgctgcctttcctcc
|
53821tacccattctaacccttcaaacccaggggatgctgggcttccgaccctcttcccctttta
|
53881taagtgtaaggtgctatccctgggaggccaatgctgttggctgcacacttatagaacccc
|
53941aagttatttccaggaccccctaaaaatgtgcaatgctgaaacaggactgttttactttga
|
54001gcaccagatgaattctggaacagtcaggtgcaaaactgaatcctggcatggcgaatcatc
|
54061ttccccatggcttccattttaatttcagaagtgcattagtggaggctgagaacttgcatc
|
54121caacacaacatgaaatctaatgaggaattccgacattgcctgagagtgcacacagcccat
|
54181gtgcatttcatttgcctgtatgtgccctataaaaaattcaaccactttgggaggccgaga
|
54241tgggcggatcacgaggtcaagagattgagaccatcctggctaacagggtgaaaccccgtc
|
54301tctactaaaaatacaaaaaattagctggtcgtggtggcaggtgcctgtagtcccagctac
|
54361tcaggaggctgaggcaggagaagggcgtgaacctgggaggtggagcctgcagtgagccaa
|
54421gatcgcgccactgcactccagcctgggcgactgagcaagactctgtctcaaagaaaaaaa
|
54481aaaaaaaaattcaaccaaattcaaacgcaccatcttttataataaaaatctctctaatat
|
54541ttaaaatRtacatcatactcccatttaaatcacaatgcttactatttttacccaaagtgc
|
54601ttctatttcttgaaagagctgatgtttactagaattgaacatgggtcatgcaagaagcac
|
54661tgagtcaagattggctgggactgcggaatcctctctctcctgcaggaatcccatccacac
|
54721gctcctggttcactttcatcatctgaaggacctcttcgtacctagattctacttgttatg
|
54781tgcagtttattttggttctaaaggtcagaggcaaatattaataaaggcatttgcagcctt
|
54841ttaagcttggaagatattcctggcagggcgaggggcaagacatggcatYagaggtcattc
|
54901accatccccggcactgtgtcccgccggccacaggacccctgcattcactcccttacctag
|
54961tagtaggatatatggaaattagcctgggaaatgttgtatgttagcatagttcatgtttaa
|
55021tatactaaagcatggcctttagtccataaggttttatgaattacccgaacatatacaagc
|
55081attctttaaacaaataacacttaaataccagagcgacaattaaaactgaccaatggaaag
|
55141gatctggaaggccctggaacaagtgccttttcttttttgttgtttttgggtttgtttgtt
|
55201tttgagggaaacaggagaggctctgaaatccaagtctacggtctcttacatgaaagtgca
|
55261aaactccaaaaagctctaaaaaccaaaagttgttactcaaattttgcaacccaccctgac
|
55321atgcggatatctaaggtcttcctgtcactccacttagagtgaccattcctatgttcMcta
|
55381tccaaatgcccatgcaattgggaagaaaggaatcccaggctggagaagtctagaatatcc
|
55441cattacagtcttgatactgtattcattttctattgaaagaaaaaaaaaatctcaattYtg
|
55501aaaaacatccaaccacgcaggttttgcagactggtactattagagtctgacataaacagg
|
55561ggcctggcatgtaattaagtgagaaggtacccaagctacattgaagaaggacggtgactc
|
55621gYagggttaaaactgagagcctggctctgatccaaagctgtgtttaaagacgtgcaaaca
|
55681taccacaccggttcaccgatcatcagccgaagctccaatatcaattctgtgttaaaccat
|
55741caatctaaagtggatatttttgttattttgtttatcttttttcccccatcaggacaccYa
|
55801gtgaaccaatttcaaatgacacctgaacctacatatttttcttaaactactgaactggaa
|
55861caaaatcaaaacatcaaaatattctccaaaagtggcgggaatggaatcgggatttcattt
|
55921cggtttaagtcccaggttgaaaagacacaagatggtcaggtcatctcatggatggaaaga
|
55981gcttaaaccacccaYccatttttgaaaccttgacctcgagaagaaagagagaaagctttt
|
56041aMgtttttaaaacagctggaaaatcataccatctgtgcatttttacccagccatactcca
|
56101aacccagctctctattttatatacctgtttttttcttgtgattatctcactgttccttgc
|
56161aagaatgagccgataatttgatactccagagggaagttcaatttctcagctgaagatgaa
|
56221gactcaggggtggcctccttcaggaattgtaaagttcaggggagaacggcaatccatttt
|
56281tatatgctaatactttgtatttagttaatttgattaagtggtaggaaatgataccttgct
|
56341cRtagatggatcgttcgcacatttgcagtaaaacctaaatgccaaattttcctccttcaa
|
56401gttcttgagagagttattttcatcactttcatttcttcctgtaccacagccattgctcat
|
56461ctctttgttccctgaagagctttaaaagtagctgtgttcatgtcatttttatcttgttac
|
56521tttaatcatgtgcttattgacaagagcggaatttgtcatcctcttccaagcaagccctgt
|
56581caccagtttttcagcgtgattcagcataagtcatgctcccctgaggaagggacactaacc
|
56641caacccacccaggaacacaaggacgtcactggagaggaacttttcccaaaatccccagga
|
56701cctgccttggtgcagggcaacttcaaaggagagggtcttgtgtgaccaggaacagataac
|
56761ctgaggaggcatcatcctttccaggagccttcgccatgacatggcagcactgttagaatg
|
56821tcttgtttgtttctccagagtctgttccttttcttaggcaagtccagaatatccaaagca
|
56881gacagaactgtttggatttctggatttgcttttgtttgtgttttctctactttctattgc
|
56941agtccaactgagtcacattcattttttaaacaacttaagattccatgtcatttaaatagt
|
57001gttatgttgtttgagaaagtccagtggcaggtccggtgagttcagtgaagaagcatgccc
|
57061actgctggcctgtggcttcggtgaacgggtgcattctttttttttttaagacaaagtctt
|
57121gctctggcaccctggctggagtgcagtggcactatcttggctcactgcaacctctgcctc
|
57181ccagttcaagtgattctccagcctcagcctcctgagtagctgggattacaggcatgcatc
|
57241accacgcccagctaatttttttatttttagtagagacagggtttcaccatcttggccagg
|
57301ctggtctcgaactcttgacctcaggtgatccgcccgcctccacctcccaaagtgctgaac
|
57361gggcgcattcttaactgtgtttctccttccgacttgctgaaatatgagtgatttataact
|
57421cagcatcctattgactgacggatggcctggtttctgtgtgctgggtgctgacagagcccc
|
57481cagaagtgcgtaaaatgatacttgctcaccaggggttcccattattttctcctcaaccag
|
57541aaacattcccagagacatgccacacagtgagaaataaacatggtgcaataaaacacagac
|
57601ggtaccgcgaggatcctctgtgaggagcaagaggtggagacagtcccaggggagtccaca
|
57661gtgggtggggtcaaagtgggtctgagtggtgatgggagagctgggtctgagaggtgccat
|
57721ctggacaggtggaaagaagggtggaaggcatttcaagcagggaaaaggaggtaagggaag
|
57781Yccagagacagtgggggaaaggctggttagggagtcagggaagaactcagtgcagtcaag
|
57841gaggaggattttgaaggcagggctgagaagtgcctgaggttggatgtggagttgggagtc
|
57901ttgacctttcccacccaggccttgatgtatcccagctgagaagatgcaaggtcagcaggc
|
57961aggctagggtggcagatggacaMaaaaccagagaccagggaccaaggagtagatccctgc
|
58021gacagcaggaccaggacaggcaatgaaatttgagaaaaatttcaaaataattgatgacta
|
58081agagaaagcagtctaaactccaatattcagtttttgcacacctatctttaatgatctcct
|
58141tacagttagaaaacagtccattttccccataatcggtagtcgtttcattagcatctaaat
|
58201tataattccttaattataagcctatcacctattctgctttccaaaaattaatccagaagc
|
58261tgtcaaatacaaacttatgtttaataaaatgaacatctgtgatcacacaccaggagcaaa
|
58321atcctaattgttctaaacccggcactttgctttgacaaccaagtaccttttttttaaata
|
58381ctttatttctttaaaacacctgctttctttacatactgacttttaaaggaagagattaaa
|
58441ttttattggcaggaacagaagttagtctctaaaatagcaaaggaagaactatgctttata
|
58501gaaaagttgcctgctacattaaaaataaaccagaatatgaatcaaaatccacaaatccaa
|
58561caggggccaatccccaattttcccacaaagagagccgacagtctgataacctcagctctt
|
58621tggaattaggctgttggtggcggctgcagtccttgttccgatggtagccgcaccacccca
|
58681gcccaggatggctgtatttccattagaattggctgtcctgccctctctgccttcgccacc
|
58741ccccttcgcccaagtccggttattcagtgagttataatttggcactaaaactcaattaag
|
58801ctgaaacgttggtcatacgtggtgtttttcccagcaaagcataatttctttgacccattt
|
58861tccaaatgtcagtagatcgattttaaagcacagagaggtaaaagtYtgtttaaaaatcca
|
58921gctcgcatttctagaaactggctggaattttttttttttaatttcaaataaacagtcagg
|
58981atgtggtgttactatattaaagcgcttcaagttttcatagcgctcgtcaaacagagacct
|
59041cggaacgctctgcagacattaattaatgttcgctccggccctggaagccatttcaccaat
|
59101ggaaattccgatgagaaaggaagaaacgaggggttcaaggccgcgccgttgtgagtccgc
|
59161tgcggaactaggaactgaaaccccgtggttcccaatgagccagcgaaagtctgtcgaagt
|
59221attgagcacccctattgaagactgtgggagttttggYggcttaatgggattgtgttcggt
|
59281ccttcaggctctcctttaaaagattccatggcaccaacgagactccaataaaagggcctc
|
59341tctaattgctttctgactttctatgaaactttctaagctatgctgacatcctcgaataca
|
59401actatggaattaaagaggagagaaaggcgaggcacagtgggtgcgcaaagaaaaagaggt
|
59461tctcagcggagcgtgtgtgaggcggggggttacgggggaggggagacggggcgggtgtga
|
59521agtctgtgccgggaaaagaaaaatatgagtgttctcttttgtgtgcgcacaaacagccga
|
59581gcgcggggaggtcgggcccggggtcacgcggctccgggctgcagctgccgccgtggggcg
|
59641gggggtcccaggcggccaccgggcgtcgcggccgcctgcggcatcagcattccggcggcg
|
59701cgggcggccgctgtcctcgcgcgaccccagcccgtccagagcgcgccccggcaccgaccc
|
59761tcggggcgaggcgagcgcagcccccgctggccaacaaggtaagcgcggcgcggggagcgg
|
59821tggccgggagcctgggcgccaggcgacccctcgacagggcgcacggaccggttctccgcc
|
59881gcgcgggtcgatgaccgacggggaggcccgagtctggccccgacgccctggcccggtgtc
|
59941cccgacgcgcctggagcccgggagggaggcgcgggcctggcctgggcccaggaggatgga
|
60001gcccgactcagggccgtctctccccgcttgggggtgctcaggagggcccagggtacctgc
|
60061gcgggcaccttggcggcgggtcaccctccctccgagccactccgtccgtgggcagcggcc
|
60121ttaccaggtccgagccggacgctcagcgttgccctccgcgagcccccagcctcccctcga
|
60181gcgccgcgggagccccaggtgcacacacgcaggcctgggccgggcctccaggcctctgtc
|
60241cttcgggcgggctgggaggtggcctggcgatgcccgccgaggggtggagagggcgaagcc
|
60301agggcggcgtcggcgaggccatcaaaggccgggggtggcggcccgccgcgttgcccatga
|
60361ccaggccgagggcatgaaaggatctttatcctccagtgacattgccaggccggcgctttt
|
60421ctgcggcctccccctcccgcggccctaattggggccggctgctaatgtgattaaaggcca
|
60481gttaaacgtttctccgagcagggggtgggaagaggccgagacccctgccccctccccagg
|
60541gtcacgccaggcccgtggtcgggggtcggcgacggtgccagcctgggacggcctggccag
|
60601gtgcctgccgattgttcacccccaggcgggcgggccggcgggctcccggggctttatgta
|
60661agccggtgggctttgggcccgaccggatttagggattcttttcgcacagtttccattttc
|
60721tggcctttggaactgcgccctaagccctcggggccctccccctccggtgcccggcgctgg
|
60781cggggcccagccacgggggcgggctgggggtgccaggctttgggggtctggagggcctga
|
60841agcaggtcgcgttgggggtctcactacctaagacagtgactcaggacagtgggacctggg
|
60901tgctgtgctgcggccaggcagagccKgcgacccgcggcgccccccgcggcctcggcgaca
|
60961gcccggttcccacgtcggcgacggcgtgggtggtcccgcccgcccgggagggctccgagt
|
61021cttggccgcccggggcgcggggcctgagagcgagtgtctgcgccgcgctgcccgccgcgc
|
61081cagtttccgaggtcgcccgcgggctcatgccctgcgccctggggccccggggaccttctc
|
61141caagccggcctgacctggtggaggctgtgcgctgcgctcggggaaggccgggctggtgcc
|
61201gggggcagcgggtcccagctctgaagtgccagcgccggcgccccactccccgcctgctac
|
61261ggtgctctcgcccggaaaggcccgaggccctggaaggagccccgcgggggggcgccgtct
|
61321ggagcagccctcaggggcgccgggctgccgcgacgcagtggctgtaattgcttcggggta
|
61381cctggggatcgatggcgtggcccagccgggtgtctgcgcctctgaggttgcaaatctgga
|
61441accagttaggatgcgggaggcRgataataaaaagccaaatgggcgccaggtggaggagtg
|
61501agctccgcacgttccatcaggtggcccgggccgcgcgctcgggcggcggcagagtctctg
|
61561gggcactcggggcgggcggcagcaggtgggacccgcggcccgacccgcgctagggccgcc
|
61621caccccctcggaccccggccgggtctctccacagcctccgtgcgcgtcccagaaggaaaa
|
61681tgctagcaaaccggaaggccgcacggggccgagccggcctcagcccggccaggagaggcc
|
61741gtcggtgccccgaggaggaaggggacccggcccgggacggccgccccgcggtacccagga
|
61801aggacgcccgccgttcccagcaccccagcgtctgaaaaatgaatgtgaactccgcaagcg
|
61861tgctcccgcggacattttacatgtcggttgttcacattttaaaaatattctctgaaatag
|
61921tctgcagaactttttcacatctaacaaatgtcagattgaacagatcagaagataagaaat
|
61981gaacatgacattttaattcaagtagagagaaagcagacggtatttttaaaataatatttt
|
62041tgtaaaaacgtattgtggatctaagattttgtcatgttcaaaatgtataattttttgata
|
62101tttaaaatacacattttgtacattttcaaccaaaaagacagggaaaaatttaaaaagcaa
|
62161aagctggaaaccaagaaaagcctggagagaaaatgggccgtaaggaaccagagcccgtct
|
62221ttctccacaccattttttttNccttcctaatagccagaaagaaaaagaaaaagaaaaaaa
|
62281aaagtgaaaataaaataatttcatattaaactaacacagagaactaattaatttctttcc
|
62341agatgggttgaagggacctggctgttttagtgtgctcagaaaatgctagactcaagttgg
|
62401ttttctttccttctgctgctcagagaatcttacgaaaaagtaaacaaccccagcctaacc
|
62461atttttttatcggcttattgaacacagataaaattagaatccttttttatttgagataaa
|
62521agacacacaggaaaagactaNttttttttttaaccaagggaatatctggggtttttttgt
|
62581atgaaactgtaacatttaactaacatgtaatgagctgaacgaccttgggtttgtttcact
|
62641ctagctcctcctgaaatcttccatttttttctgagatggcttttccagtgatcttgtgtc
|
62701agtaagagaggaatatacagtgcagcaaataatttgtgcattcgtggtcaatacatttct
|
62761cagtcaaaaaatcaaaaacaggtcaatggctggttattaggaataacctttgaaccgaac
|
62821aggaaatggggaaaatacctgtttgttgacgcttgcacgcccaggaggagaattgaggtg
|
62881cagttagtttcactgtgtgagggagagatgccgctctgtccagagggtttattggaatgc
|
62941caggccccaggtgtttgggtgtgtctatgcagacagttagtgctgacccctgaggatttt
|
63001gatgtgtataatcatgccataagaggaaggcaggtgggtcaattgtcagtgggagcacag
|
63061gagatgctggggcatgccggagcctgggcagtttctatcctgataccttccgtgtccatg
|
63121ttttagtcccatattgaggacatgaaaggtccattttatgtttctctcctttaaaaactc
|
63181cccagtggcctactcggcagcattgctggggacccactggtcatttttcataaaaataag
|
63241accacagtgtggaccaaaacttgggatctgagatgtccttgagctcacctgtcacatcga
|
63301gtcaccacctggagaagaaagatttgctgacctcctacagagccaggcaataggacgttc
|
63361agcctcagtcctgattacgggtgggcagttgggtttatgtgtgtgtgtttgggttttttg
|
63421ttgctgtttttgttttgttctgtttttctgggaaaacaaaggtccctttgggggtacctg
|
63481ggctggccggtacggcaaacaggaaagccagccaggtcaggaggagacgtggcttcacgt
|
63541tggaatgccagtttgctttgtgattgtttattacaactgaaggttttgtgtcatctagcR
|
63601ttgcccaaagtagaagcccattcccaggatggatgaatctgtggtaagagataaacacaa
|
63661gaaacaaatgcccaggggaggaggagaagcagattgcctggggcaggtaagagggctaca
|
63721cctggaaatgcatctgctggggttctcacccacaccagaatctctggtcagagcagctct
|
63781ctttgaagaatgccagacaaacagaaacctggccacacccccaccagagttacctgattg
|
63841aaacacgaatctgatcactgaaagccttcctgcatccgtctgctgcacgcaggaggcagc
|
63901tcggcctccttccccagtggcctcccagccctacctctagaatttcctggcccctgccct
|
63961cctgccaccctgatatcYcttaStccctaagacacttgYccttgtcgccgacacgggccc
|
64021agcggtgagagaggcgctctcNgcccattgcccgtgaacacactgcgttcagggcttctc
|
64081agagcaggccagcctggtggagctgctttggggcctagctctgggggtctcaggagtacc
|
64141ccagcctgcagataaggaaccctatgcaatgtataaggaaaggaaagcatggcccatgtg
|
64201agcacagcattagggccttggaactccgtgtttagcaccccccatgctgcagccaaacat
|
64261tgacaccccaagttcYaggaccccatgagatggtgccttgcctagccagctgcgttgatg
|
64321tgtgggaaggggcatgttgcggaaatcctccagcaggtcctggctcctgtcctgtgccca
|
64381gcactggcgttcttgttcagagaacaaaggcccggaggcccctgcagaaccaagaaagcc
|
64441tgaaagccgtggctttcaaagcttgctgaccgtggctggggtaagaaatacattgtgcat
|
64501ctcagcccacggcaagccagacaactatgtataaaataattaattaactatacctagata
|
64561accaaaacacaatttttgcaaaagaatggttctcttactagacgtcatgaatgctgatct
|
64621ctgttcatcctatttcttttttccaaataatggctgccacccctgaaacaatcccatgat
|
64681cctaatgggctgcagcgtggagcttgcagaccaccctttagagctgaggttgtgtgggtt
|
64741aagcctgagtggagggagacccgcagttccttcctgctgcatctcctgcccccacttcca
|
64801gccctggagtcagaacctcctgctggaatcctagccaccacttcctactatgacattgag
|
64861aggccacctcccctcctgagctggagcctctgcttcttcctcttagaatgaggaggacaa
|
64921ctccctgctagggtcttagagaggattcagcgagatcatgtaccagatgaggtcttgact
|
64981caatgtgtctgcccaggctagcacctgacagtcatctgtcacttttgatcctgtgcctcc
|
65041ctggggcccaagatgtcttctcccctaccccccagtagccctccagtaaaatcctcctcc
|
65101ccccttccaattccactccagtcttctccttgggccagctcctcctcaagccccactgca
|
65161gattttgggactcacagatctgtgcagcgcggattaaggcctgccaccctggtggactct
|
65221caggcctgggctctgcctggctcgccggcatttatagacacatgtctgattgccagttag
|
65281ccccgatccaacctcaacagcactgtggacacagaggctgtgcttcttcccatttgcaga
|
65341taaagtatatggggcccaggaggtatcatcatgtgaccgtgagtcgcacagttagtggca
|
65401gagctggggtaggctagctctcctggccttcaaagaccatcatgctcatggcccagagtc
|
65461cttcctcctggcagggcactagggccctttctgacaggctcgcagcaaccagatttgttc
|
65521cctggctgcccacctccacgtcctccaccctgggagagctgagttcgttttcctttgact
|
65581gtttttttaatgcttccctcaggaggcaggccacagtcttcctgcaccaccctcacgggc
|
65641tctcactgctggagcaatgattactcacagatttacccaaggagagtgtgtacttggaat
|
65701ggctgtccgtgtgttccctgtgcacacacacacgcatacccgcacatacactgtggtgac
|
65761ctgacacacacacttccgtgatctcacacactcgtgcacacacacacactgccctgatct
|
65821cacacaaacacacaaacactgccctgatgtcacacacacacactaccctgatctcacaca
|
65881ctcatgcacacacacacacactgccctgatctcatacacacacacacacactctgcccta
|
65941atctcacacaaacactgccctttgccctgatctctctctctcacatactgtcctgatctc
|
66001acacactcatgcacacaaacacacactgccctaacctcacacacagacacacacacactg
|
66061ccctgatatcatacacacacacacagacacacacatactgccctgatatcacactcatgc
|
66121acacacactgccctgatctcacacactcatgcacacagacacactgccctgatgtcacac
|
66181acacacacacacgcacactgccctgatctcacacatacacatacacactgccctgatctc
|
66241tctcacacacccactgccctgatgtcacacacacacacacacacacacactaccctgatc
|
66301tcacacaRtcatgcacacatacacacacttccctgaccctatcactctgcacattggagc
|
66361taagctcatgaaggctgctcatgcattttatttggcaagtctctctcacatctttaatca
|
66421cactagcctgcccactgccaatcaataaagattaggaaatcgattgctaacttactcttg
|
66481ggttagataataaaattgtttgaaacatgcacctggaggaatttatctgtgaagagtcct
|
66541ttcagagtttgtttcaagctttgcaagtctctcatggctctgaggtcggggaggctgtga
|
66601gggatcctccacgcccagcagacgtggaaggagccgacgttcttacgggagatggacaga
|
66661cggtcagcatgtgaatagtcccctgcatgcaggtgaggactggggcagtgcagagccgca
|
66721gcagggatgggctatgcctgggagccgccagctctggatcaggtggccagggacggtcat
|
66781gctgaagaggaaggctccagtgaagctctggaagaatgttctggtgcctgtatgtacaaa
|
66841ggcccccctaattcaggacctggccctgtacagatgaggagcaggaaggagccagtgtaa
|
66901ctgaggccagtgtggctgcagcaaggggctggaggcgtgagaagaaacagaaaagaacgg
|
66961agggccatttctgcctccccagtccggatcatcctcctcctccaccccagagccccaggg
|
67021tgctgagccttgcgcccctgcccctcaaggctatggaatgtcattgccactcagcgtgaa
|
67081ggttctggaggggacctcaaacaccaggcccctctgcccagagagccccagtggacccgc
|
67141tgagccagggacctgctccttggagccaaccaccttgtgacttgtgaattgtgttgagtc
|
67201ccgtttcctttttcccttttgtttattgctttgtgtatctggcagctttatcccaaagct
|
67261gctctcacgtggtccctctgtcccatcctgccattttcctccctctggggccccttgcat
|
67321gggagactgggagcagcgtccacccgccacccagcagaggctcaggtcctggagttaaaa
|
67381gagaagcacaggcaggggaYgctctccaaactgccttcagcccgcatctttgaactctgc
|
67441agtaggaagactcctgggcccccatgtccccatgcatatgcacctgcatgcatgtgacac
|
67501acttctcggcccatggagaagactgtccgcacgggggtgtgagctgcccagcacccactg
|
67561atcaattgctgcattcccagctgcctttaagctggcatggggcgccctctgaggcacgcc
|
67621cagcccctggggcctagactctggtgttctctaggaactgtctatctctgtgtgtgggag
|
67681ccacagacttgggctttcagacccccacaatggatggctcaggcctatggctcaccccca
|
67741gcatctgtgaccaccaccactgcccaccttctttgcctaagcattacttctggggggcag
|
67801ttcttcacttatgtgtgcaagccagccttctagaaaactctttgctctcatgaccaggca
|
67861ggccttgcacagtccagatggtgaagcccagttcctaccttccagtgaggagcacctgac
|
67921ccttcaggggcgatagacggggccctgcacagatgggacaggacaggtggggtgcacaga
|
67981ggatggcaggtgccctctgagaggcagggtcggggcaggtcgggcaggagcctggcatct
|
68041gtggctgactgtttggcccctcaaggcctgttttgctcacagttttgcttcctccttgct
|
68101ctctgttttccctgccacctgaacttggttgcatgctgctttctgtccattgccctcagc
|
68161ctctcacctcagtcatgacccttaagccagcacctcccccatgcgtcttactctgaggtt
|
68221tcccaggagcatgagcctcctccagtgtcattgcggctgctttgatctccttaatggttt
|
68281tgcttgagtgtggattcatattcagactcttttagggacacaaagacccccaaagtggat
|
68341gaatgccctatggaggcagatgcccagttgggggcccgaggtctggctggcctgtcctcc
|
68401ctgcccagggtttgctgaacaccccagccacatgctccaggcacacaccgaagcttcagc
|
68461tcaagattcacctcggaggagggcatctagtccaagccacttcgtctaagaggcgaccaa
|
68521ggtggccaggacttacttgccatgagaccttggcaagtggacaagtgctgagagtggtgg
|
68581gaggtgacaggcttctctaccagcactggcaagcacttaatccaagccccgaggctccag
|
68641ctgcaaactgggacgggaatctgatgacacccaccctagagggatgggggtaaatgtaga
|
68701cgacataatttccatatgtctgcattgagcgttcacatacatgagcgtcctcagaagcat
|
68761tatctcctcatgcttctccaaggaatgtgcccttttcttaaccctggttgactgagtcct
|
68821accgaggaaggaagggtttcaggccacaccccagggatagcgctggatgcccccagccag
|
68881gccaaggtggtcagatttccttgcaagagtttgagcaaagacacagagattgaattagac
|
68941tgagctgggcctggaggcttgaggtcctgtcgacgaggagagcgatatctcagtgtatga
|
69001atctgtgggttttctgtgtgcccttgcagtcctggggaccctcatggcccttggtgagcc
|
69061cacattgaaggagaagaaccaagaggcggcagagaatctagattcaggctgcagaaagtc
|
69121ttgctactgcagaggtgagacgaggccagggcaggaagggagcaggggtggggtgcagga
|
69181ccctgagtcccctagaggccacggtaggacatcagcagcaccagggggagtcaccaaagc
|
69241taagtgccaagatgYggtcgacYgaggacctgctcctggtgcccgccccttcagcccaga
|
69301gacggtgtgtggtccgtctccacccagcacaaccgtcctaaatacctgaatgagtttcct
|
69361tgagctcctgcagcagagacccataaaatgcttaaaggagcagaaatctactcccttgct
|
69421gatctggagcccagaagtctaaagtcaaggtgtcgacagtgtcgtgctccctctgaaggt
|
69481tcctgggggtgcccttcctcacctcctcagctcctggtggccctggacatccgatggctt
|
69541gcggctgcatcatccactctctgcctttgtctttccgtggctgccctccctctgcatctg
|
69601tctctgtgtccactcctctttttataagatcgccagtccttgggtctaggccttgggtct
|
69661agggcccaccctaatgcagcgtgacttcatcttaactaattacatctgcaaagaccctgt
|
69721ctccaaataaggtcatattttgagcttctgagtggaagtggatttgggggacagtcatca
|
69781acccagcacaatgcccctcctccccatgctctctaaagagagaaggatcttggacatctt
|
69841gattggacacgatgacacgaagacaaaagtttctgactagctaggccaagggtggacaca
|
69901ttgtccctggagtgacaagtcgggccagtgatcttgtagggacaagcctacatccagagc
|
69961agtgctggtataggggcaagccaacatccgtggcagtgctggtataggggcaagccaaca
|
70021tccatggcagtgctggtataggggcaagccaacatccggggaaaaccaaaggcctgtagg
|
70081aaaagcctatggggaggatggagagaagagggatggagccctggatgtaacggggacctg
|
70141catcctgtatccctgtccctatgatgctgtgatggtgcctgactttctgtagaccaaagc
|
70201tctcctttttttttttttttttgagacagagttttgctcttgttgcccatgctggagtac
|
70261aatggtgtgatctcagctcactgcaacctccgcctccgggtacaagcaattcccctgtct
|
70321cagcctcccaagtagctcagataacagtcatgcaccaccactcctggctaatttttttgt
|
70381atttaatagagacggagtttcaccatgttaatcaggctggtcaagaacttttgacctcaa
|
70441gtgatccacatgccttggcctcccaaagtgctgggattacaggtgtgtgccaacacaccg
|
70501ggccccaaagccctccttttactggagctattttgcacgggatcaataggcttctgcagt
|
70561ggtgctggccatcctagcatccctggctttccttccctgctgtggtctatatagtttggg
|
70621tggagctgaacccatagagttgccggctgcacatgggaccagtgccctccctttggacgc
|
70681tgcaatcagcttgggagtttactcacagctgaatttgagcaacatgaggaggggagattc
|
70741ataaactggtagaatgaaccatagagctgacagtcacctggccactttgaggagaaggcc
|
70801tgctggagaacgaagacctggaggaagctgaactcagacagatggacagacagacttggt
|
70861gacgtcattggaggcaccaggtccagctgaaccttgaactctgtcatcacaggaaccagt
|
70921aaattcacctttaagcccaagttgagtttctgtcactcacccccYaaaaaagtgctgatg
|
70981ggagggtgtctgggtaacaactgcatgccagttgaccacatccatgccgctgccagcccc
|
71041ggatctggggtagagtctagccgcctgagggcatcaagtttgtggcccatgagggtcgta
|
71101gccatgctacagggcagaggacaagaaccgggtccccatgagaccaaaaggagacaatag
|
71161gtggaaaggatggcctgcactgaagccggggccaccaggcttgtcgcccctcactctgtg
|
71221gacagactgggttgcaccatttctgagggaatctccatgactcagtcctgggcattgcgg
|
71281ctggggccagtactcaaaatggcagcagacgcagtcggcctgccagcccctgctagctct
|
71341tgtttcaggtcagaggaagaaagtactggtggcctctggggatccagaaaggactggtgg
|
71401cctccaggtgtccaagagtcttctcttcaacgaacatggtgagggggagcattgtgctgg
|
71461gttgatgagtgtcccccaaaccaacttccactcagaagcccaaaatatgaccttgtttgg
|
71521agacagggtctttgcacacRtaactagttaagatgaagccatgctgcattaggccagggc
|
71581cctgtgtccagggccttccctgtgaggtggccgccaggaggccgacctcagggacacaag
|
71641gactggaatgtgggggtctttggagaggcatgacgccccctctgtgagtggacagacatc
|
71701aagaatgaagggagccctcaacggggatggagcagcccctgagacctgagggtcccaccc
|
71761tgggacaaaggtgccctgagctcaagccaggacacccagcagctgccggccaggctgtgc
|
71821ttcccccacagcctctccacaccctcgctgtgtcttctgtaagatgaggtcccctccatt
|
71881accctgggccagggatctcaaaacggaaggccgccaaccagtcagcggccaggggctgga
|
71941gcccatggtttcccatggctcccactaggacacttgccagagagggggtgggtgagctgg
|
72001ttcccatggagacaggctcaggatccccagaggccaccagtcctttcttcgtctgacctg
|
72061aagcaagagcaaggccaggggcttacaggctgaccgtgtctgcctccgtctcaagggctt
|
72121agactgagtgagactggcagaggccctccaggtcactcccattgtttcacagatgaggaa
|
72181accgaggcctaccgggagggagggccttccgacaagtcacggaactgatcgggggagagc
|
72241tggatgcctgctacaccgtggctctgctgtctcccgtggaaacccgggcctctgttcgag
|
72301cctgaagtggcctctctgcaccaggctgctgggagacctgcagtcaccaatggcaacgtc
|
72361actcttgcaacagccagtggggtgtggggcagcagacgaagctcgagtaccgcctgggtt
|
72421ccaagacagaatgagacaaagtgaggggtcatatgggtgcctggcctcccaggcagatgt
|
72481ttctgttaccaggtggtctttgaattctgtcctggactaaatatagttccttgggcattt
|
72541ttgatcttggtaatcatgcaaccatggtacagaaataattggtccgctctcatcttttcc
|
72601agattacagttcggggcagctgagtaggccctgggtagagggcacagaggtatggctcgg
|
72661gtgcaggcgggaccctgggtgacacccacgcagggtagagcccctcccccggcctcggtc
|
72721tccccacctgtgtaacgaggaagtggactggacatgactcacggttcttccatgtccagc
|
72781attctgctttcagcatcacgggaacgagaggtgatttccgtaagcaggctccaaggtgcc
|
72841accaccaagcccagaagtatctttcccactttgcagatttcctacagacccagtattctc
|
72901tcttccatgggttgagtttctaaaatcacatgactgtatttttcttttaatacagaaaag
|
72961cataataaaggcataaaagcccatgcccctctgcagagcaccctgttgacattttctgaa
|
73021agtaagtcatctatgcacctgggaagaaagcacagaggactcagaaaggccaaaaacaaa
|
73081aacaaaaaagccccacctcagcccctgcccctctcccggagaagccggagttgtcagccc
|
73141atgcagcagagttggtcaggagctcaagttcacatcccccaaccgccacatactacctgt
|
73201atcacctgggcaggttctcccaatacctcagtgtcttcatctgcaacgtgggtaagatgg
|
73261gaatgcccacctcctggggaactcaggactcgctgagttaactgcattcagggacctgaa
|
73321agagactcgccaggcagtaaccccagtccacttgttccatgctggtgtgagcagtgactg
|
73381catattcttccaaaagcatctaccccatctattttttttttttttttttgagacagggtc
|
73441tccctctgtcacccaggctggagtgcagtggcatgatctcagctcactgcaacctccacc
|
73501tcccgggttcaagcgattctcccgcctcagcctcctgagtagctgggattacaggcgtgc
|
73561accaccatgcccagctaatttttgtatttttagtaaagacagggtttcaccatattgctc
|
73621aggctggtctggaactcccaacctcaggtgatctgcccacctcagcctcccaaggtgctg
|
73681ggattacaggcgtgagccaccgcgctgcctatactatctatttgttaagccccaaatgga
|
73741tcatactttggttcagcctcttgcgttctttgccttgtttattttagagacctgtctatc
|
73801tcaatccatgcagataaatgccttgctctttcttaggtgccaccaagcatagacacagac
|
73861ctccccaatgccccatctttcgccattaatcaacagtgttgggatggtaggacaccagga
|
73921gttagacacctcaaagcaccggttctggccacactggttatgcatattgtactcgactga
|
73981ttcacactctcatggccctggatgagtgtctctggccatcccgcaggctgggtgcttccc
|
74041agtctgagcgtggtggcctgttcttctcatggctattaccccgggcctctgtgggtccac
|
74101cagccagagttctgatgcccggcgcgctcacaggagcctgacttggggacagctttatga
|
74161ggcagtgcagggaccttgaggccatagtggtgcagcagagaggtggggatgaggaggggc
|
74221cgccagggcccagggcagctcctggactcactgggagagccgaagtccacaggcagctcc
|
74281tcacgccttgtcaggcctgccctgcactcagctcccagattttatagaaggaagtccctg
|
74341cctttaggcccagtcaaaaaaaattggactgggatattaacaaccaactttccctggtgc
|
74401tttcctgagtcaacctctgcagccggggctggctcagatgcctgccttggggccctctgg
|
74461ggcagcgtgtggagtcagggccatctgtgatctcctcagcaggttccatcctgaccctgg
|
74521agagccagctgacttgtggaaacagcaggatgccattctgagccaagcccagtgggtagg
|
74581tacacagggccaacccaggtcacccatcaagtgaccacagagcaatgacacccatctgcc
|
74641ccatactgtcactcgcttagagaaagttccagaagaggggctccaagcatgtgtcccRtg
|
74701ataaagaggcggcctctgcgagggttaatttcagtgtcaacttggYggggccacagcgcc
|
74761cagatatttgaccagacatcactctgggtgtttctgtgaggggcttggggatgagactca
|
74821cattggaatcagtgggccaggtaaagcagtttcccctccctaatatgggtgggcctcatc
|
74881caatcagttgacagcctgaataggacaaagggggtcccgtcccctgagtaagatagaatt
|
74941cctcttgcctgccagcctttgagctgaatgtctagctttttcctgcctttggacttgaac
|
75001tgaaacgtccgctctgtctaagctcgggctgctgtagactgtgtggcttaagcatcaaat
|
75061attcatttcccaccattcaggaggctggaagtccagcaccacggtgctgccaatttgatt
|
75121ttggtgagggcccacttactgctggccttcctctctctacgtcctaatgtgacagagatc
|
75181agagagagagagctgccctgtctcttcttataagggcactRatttcgttcattagcgctc
|
75241caccctcctgacctaatcaccttcaaaacaccccacctcctaagaccatcacattggagg
|
75301ttggggtccaccatatgaattttggggggacatgtctagtccctagtagcctcttctggg
|
75361tctccagcttgctgactgaaaatcttgggacttatcaattcagttattccaggagccagt
|
75421tctttacaataaatccctgtttgtgtgtgtgtgtgtgtgcgtgtgtatgtgtgtgtgtgt
|
75481gcatgtgtatgtgtgtgcatgtgtgtacattctgttggttctgtttctctggagaacctt
|
75541gactaataacattctccaaggtgacaaggagactgacagggggagagtgaagtttaacac
|
75601atcggttaaaatagtcacaagattctcatcaactgccacaaatggcatctggccacagcc
|
75661actgagcttggccacttctccggctttgcaaacgccgctggatgcgcccggcctgctgtc
|
75721ccacagtcccaccctgccttctcctacgtgtcctttctgaactgccttccaagctcctcc
|
75781caaccccgtagggtccacctcattgtgcctcctttgtctcctcctccgcagctcccctcc
|
75841caacactgggttcctagctcctagaggtcagaggtcacacttttccctctctctgtctcg
|
75901gtaggtgaaagcagtaagtggcacctaacgggaagtgatggggttggtggggaagagaac
|
75961aaagtgtggatcagtcctgaggaggctgtgcaaagacccagtgctgggtccaaggcccaa
|
76021ccccaagaaccaggatcttgtgcctcagtttcctaactgtaaaaggggatgttggaatca
|
76081cgtgtgtcaaagatcccttccaattctgttctttgtgggttttctcatgtctagagctgg
|
76141aagagggcaagcagagaacgcccccgcctccaggccccgagcactgtgagctgtctgcct
|
76201gcacagggctgcctgaccccaccctcctgaccacgtccccactcctggggacggttcccg
|
76261gcctccacggcatcccggggaaggcaacagagatggactggagggcacgggaggacacgc
|
76321attcactgaccgtccagcccagcaaagcaagaaaccgtcaaaaactaaaaattccatttg
|
76381taaacaagatcgaattatttgattgtgaaaccagggtccatggaatttaaaataatttaa
|
76441tatgaaacaatatcatttgaaatgctggccagccaaggacctggacggggagggggactc
|
76501tgtcctcctgtgcccagccacgtggaaacccagcctcagagaataataacaaatcattct
|
76561acagcaagtgtggctgagattcagctacgtggcagccccaggccaggcccggggggcagc
|
76621cggcgaagactcctcgtcctctcagagtttacggtctaactgagcagaccagggttggac
|
76681aattaaataacgatgccagaaagcaggagaggagtgagtgggtggcactcaagccaaaag
|
76741ggaggcctgatagagccaaggggagtgtgctgtgggccatggcactgccagaggaggctc
|
76801ttgggtgctctggcaccgcagtgagcagctgggggcttggtaagtagggaaagccagcac
|
76861tcagaggagaaggtggcagaaaaagaaatattcagaataggaagcgtgatcatttgcaac
|
76921cccagctttgtcttgtactgcccatgccaacttgggcaagcacgttatcccaagcctcag
|
76981tcttctcatctacagaatgggaacaatcccagtccctacttcctggctgttgtgagggtc
|
77041ggaaatcattcacgtgcagccctctgggagcccgtgtccctgacagacagtggtgctcca
|
77101ggtggagcacgaggcaccgctggcgctgtaagcagatgcctgtggagggaggggaggagc
|
77161aggtttcctagaggcctgggaggggctgatgcctctgcagtgggctctgcactcagctgc
|
77221cttgaaatcccagcaacagtgcctgcctggagtgacgggagcaggctctttggggaccgg
|
77281ggggtcaggagggcacatgcacgtgccttgcagctggtgcctcttggaaggatggggagg
|
77341cggggacccggcagaccctggtgcaccgacactccacagccatgtcttctgcctcaacat
|
77401aaacacgattgggaatagttcaggactgtaagagcaagaaaaacaaacccagggaaacca
|
77461aagagcgcgcaaatgctaactttcatgtcacatccagaaaccacatgttcatcaagccac
|
77521ctgcgggcttgtaactcagtggggagacacagggttgttgtccttagaaaaatcaagcta
|
77581tccttacagctgcaaggggaaaagtccagttgctgcctcccctccatcatcctggaccag
|
77641gtccccccacagaacagccctttgaggcagccagggagcttcccgtcgctgtggccacct
|
77701ggggcatggcccctaaacctttccgtgcacagggggttggggaaaagccccggacctcca
|
77761ggctgatgagtggcaggcccagaacccccatcagggtgcccagctccccagtctccctgt
|
77821ctcaccaccaccccaacctgggctcagccgcccccgttcagggcaggcaggacttgtcct
|
77881ggcctcggggaggggccggggaagaggagagaagaccccagtggggccccccaggcccgc
|
77941acatgccgcccgactacctgtgggcttggggagggctccagatcactcctgccctcagag
|
78001acggcgatgctgagaagtgttatttttattcctccccaagccttgccagattacattgtc
|
78061aaggccagcactttggagatatttccttggtttcgcaattcacacagtgactaacacatg
|
78121ttacattttgaaaacttctctgggtaaaaatttaagctgaattgtaaatacataaaagtc
|
78181tcaacgttaatggggtacatgatatctcagtgactattgtgtaacaccaagattcggaaa
|
78241ggatgtggaattccatatagtcgggtgaggatgccgtcccagagccgccctgtgaaagca
|
78301tcattgtgagcagcaaccttgcctttctctgcggttatgtaagttacaaaaccctttgcc
|
78361tcttggcctcgtgaggcatcaggaccctcaggaggctggaactgcagagctccgcccgcg
|
78421atgatgaatcccctccagggggcatgtgcacacgtgcccggcacaccctgccaggggctt
|
78481catgcttgtgacctccttggcaccatgaggcactgggctacaggtgacaaaactgaggca
|
78541catgcatgttaagggacttgcctaaggacatcccctgacagaggcaagcaggactcaatc
|
78601ccagatggaatgctcactgctatgcccatcaccccctcagcccctggtgctgggcagcta
|
78661tgagccatgctgtgccgtgtcatgcacactgcaccccccccccaatgatggcacaggatg
|
78721gcccccaccaggacaggcgatgcatgggcggtcacctggggtcactgtcagagcatctgg
|
78781actacgaaatgaaggggatgggccacttggcagtgtccctacgcaagccagagctacagg
|
78841agcacctgggcataggtgtgggaaggaggcagggagagaaggaaggaagcagagaagcca
|
78901agagtggttggggagtggctgtgttgggagccagtccccccactgcccaggctcctgccc
|
78961agccgagtgcccagagccctgcccatctgcagcagccctgcccagccctcccgagcctcc
|
79021acctgcctgttcattgctttgctggatgacgcttatcagcctctacttggccagttttct
|
79081gtttcatttccccgttcaacattgatctccacacaggactgtagactccatgcaggcagc
|
79141acactgtctgccgggctcctggccgcatcaccagagcctggccccaggactgggcatggt
|
79201gggcattgagtagttatttgttgaatgtatgcacctccgaaagaaagagggagccaccat
|
79261cctcgcctcgctgctgtggctcactgagtggctttaccacctaagatgcctgctgccttt
|
79321ctcctgctccttctgtgacctcagacaggcagtgcaggggaggggtaggcagggcagctc
|
79381tctcctcagcagagctcaccttgggccactcaggggccaggaagtggcagtgcaactcga
|
79441gacgtttatgacacaatcaactccctgctgaatattgatttttcttcaaagctcagggcc
|
79501tatctgtctgggctcctcccagcgccacccccagccctgcctggcgagcctggagactcc
|
79561agcagcaaggcttcatgctcccagacgctgcaggtccccctactccgccctggtcagggc
|
79621cctccccaccgacatcctggtaacttagacattgcaagccacagctgccgcagtgtgcca
|
79681gaaaacgtccctccaaagacacaggatttatgaaggactgttctctgctgtgtcaggaag
|
79741ggtattcacacaggttgggaagcatctcatgtgctcctttattgactgtgctgggaaata
|
79801ctgaagtgggcaaatgccgtccatctgagctctcaggacacgtaggggataaaggggagt
|
79861tgaggctgaccaggaggctatcacaggtcagtgtgataagcacaaaaataaaagtatgcc
|
79921cagggcaccaggacggcaggatccgctcgaagtggggtcgacagaggcttcccaaagaaa
|
79981ggaagtttccaccatctcttgcgattttcatttggcatctccagaatgcctgttctatta
|
80044gaaccaactaaggccttaatgggattactcagctttcagtcataacaagtttgtctaggt
|
80101catgtagggaggtactttaaagtcattcttccttctcttttattatagcaatgacttaca
|
80161atgcttgaaaaaacattttccttaattcaattaccaagtgagctaaatgcatttgctgga
|
80221gataattaagaatctttacaaatataaaacaattatcccatcaaaatacagtgctggatg
|
80281ctattattcacgctgggttttcaatcagagccccctctccccttttaaagcaattccaaa
|
80341gccccctgtgcctgcctttgctggccgtccctgtgagcccaggccatttgtcctgccagc
|
80401tctccagcaccatggaagggcgccctgtctgcccgacccctggcccggagccaccagagc
|
80461tctcttcgctcacctctctggtcctagtcttggcccagagcaggtatcaaaaacaacgtg
|
80521acacagaccagaggagccgggggagacgtgacaactaaatgcaatgaagtcccctggcgt
|
80581gggtcctggaacagagacaggacattaatgggaaaactagcgaaatccaaataaagtctg
|
80641gaattgagttaacaatggcccaatgtcagcttctgagtgctggcaaatgtaccacggtaa
|
80701tgtgcgcggttcacaaagggaagaccgggtggggggcgaacgggaactctctgtactatc
|
80761gtaacttttctataaatctaaaattgttccaaaataaaagtttataaaaacaaagcaaaa
|
80821caacaaatgggactgagtgggcaaaagagaaggcagaatgtctccattgctgaagtgagt
|
80881attcctggtcttcagaaacccgcctggcccccacacccaccccccacctccagttgcagt
|
80941cccgtctcagttccctctgaagacaagtctcagggaccagctgcctgcggttgctgcctc
|
81001cacttcaacactatctctccccacgctatttgtcctgagccacaaagtgaaggtgaggtg
|
81061tcaaagtgagcacctgcaggacggcaccctggatgtttagcctaagaaagctcccccgtc
|
81121ctccttagagaagcccccacattgcacaccaaggagtgaggctgaggcagtgctgctgtc
|
81181agtattctccaaggccgctaactggacctctggacaacctgctcttcacagggccccctc
|
81241agtccctcctgtcctggccacaggccacagcctccctcagacaggctggaatgaaggaac
|
81301acactgagcctggtctgcaaaccctggcgggggcttgtactggacagcagtgctgatatg
|
81361gggtgggctgagtatagcagaggcataacttccatcccccaggtctgggtacagacacag
|
81421gcatgacttccatcccccagggctgtgaaaaggagacgctgtccaaggcacctcatctga
|
81481cggtgcttgcgatgaccgtgcaggacatcagaggggccagaagcacccacggccctgcgg
|
81541tcggtcgtatttacctcatcattgccatgcctttgaggagctttcctgggccttctgagt
|
81601gcctgagcttgggaagtaaccagtggctctatgagatttcccccagagggcactacgatt
|
81661ttcatgggcctctcccaccataaaaatacctgtatttaaaaacgtgtttaaggaatacaa
|
81721atccttctaccataaagataggcatgtgtccttgcggcactattcacaatagcaaagaca
|
81781tggaatcaaccttgatgcacctcagtggtggactggataaagaaaatgtggtacctatat
|
81841accatggaatacgatgcagccataaaacagaacatcagacatcaggtcctttgcagcagc
|
81901acggatggagctggagggatggagctggaggccgtcatcctacgcgaattaacgcaggca
|
81961cagaaaatcaaatactgcatgttctcacttataaatgtgacctaaacactgagcacacat
|
82021ggatacaaaggaggaaacagggaacactgggacatactctagggtggagggaggggagag
|
82081gctgaggatggaaaaactacctttcaggtattattcggatgacctgggtgacaaaattat
|
82141ctgtacaccaaaccccatgacatgcaatttacccatgtaacaaacctgcacatgtacctt
|
82201tgaacctaaaataaaagctggggggaaaattgtagtaaatgtccctaagtatgaaataaa
|
82261taaataaaatttaaaaataaaaaaattaataaatcttcaaatgcttccacatattttttt
|
82321ctggtttaagcaaagttagagagatgttcttgggcccctaaaggtatcaggttgagacag
|
82381acatcctcgccctgggcctgcggagcttaatggacaggccgggtccccgggccacactta
|
82441ccagttaagtgacctggggcaagttacttaaccaccccatcttcaatccctcatctgcaa
|
82501aacagggataatgatacctgctctgcagagcttttatgaggattgcttaagctaattggt
|
82561gtaaaagcattaattccagcctggcccccaggaggcgatcaataaagaagcattactctt
|
82621gtgaaatactctagccatcagagcaggcaacaatgtttctgtcttctaaaacgttcccaa
|
82681gagagcctcggctttactctacaaataagacctcttgattttattctgcgagcttaaata
|
82741tctttgactctctcattacctgaaactcaaggtccttaaataggtctgaggcccctaaac
|
82801gttcctctaagtgccctgtagagccatcacttagtggctgagacacactcgctggctttc
|
82861ccatcgacagatgcctcggtggccctttctggatcatctaatccctgctccaggccactg
|
82921gctcaagttccctcattgtaataagtgcaagggagggtgtttatgaaggaaagcgggttt
|
82981gactgaagtccaggctgaactcggaatttccctgtttgctttctcttcctccccgggcgt
|
83041gctgatggaccagacctgcgggagctaactcaacaggcctccagctgccagagatttgag
|
83101atgttagtcagggctcaggggcggggggctccgggagcagggagcagggagctggagccc
|
83161tgaaaagacctcagcgtctccttgtcaggactgaacttccaccttgggtcctcgctgagt
|
83221cttattttgctaatgagatcagacaggcttgtaattttaggtaactgcaattgctaagac
|
83281tggaagagagactcattctctggcattcccacaaattcttcccagtttgtttagcttagg
|
83341aaattaggcaagagcaggtagaaaaacggcaggtcaaacacaagccattgcaagaaactg
|
83401actcatgctttaccaacagcgttattcatcccccccgttcctctccctggctatgtattt
|
83461attcgtttattcagcaaacattgattgagcacctaacatgtgtctctgccttttcacacc
|
83521ctcaggcccttgcccaggctgcatcctccgccatgtcctcccgttgacccactgtgtatc
|
83581cttctagaccaggtcaaaggctacctcctctgggaagcctgccccaaagttccatgccag
|
83641acccaatccctgcctctctgtaggaaggagactaccatggctcccaagaggagcactggc
|
83701tgccgagtcagaagaggttggctgagaagcacggctccaggacatccctgatgtgtggct
|
83761tgggcaaggtactgaggctttctgctttctttcctcttctataaagtgtgaatactaata
|
83821cctcccaaaactaagtgcccagggtgctacataaaatacactacacatcactttccacgt
|
83881ggaactgagcttacaagaaaggcaaggagtttcccagaggccaaaggcaggggaaagcca
|
83941agagcgagagtgataagtcggtgctggcatgaagccacctcaggtgtcaggcagtcccag
|
84001tggctttcagtggccatccaggggcagagagaaggtgggatggcaggattgccatccttg
|
84061caccaaaccagaacctcagaggttctaacgccagtggaggggcaacttgagaaaaccacc
|
84121tgctgcatgtggaggcttctactgcttacccatattaaatgctcttcttcctccaggcga
|
84181cagatgaacacagtctctgaccccagcaattagcctgggcttgggactagctctggccaa
|
84241agggctctgagaggaagcgatgtgaatcgctcctagactaaagccattgacaccaccaga
|
84301ctcggcagcgccatctctctcctgtggcacgtgtggaggctgagcctgaaaatggtaacc
|
84361tggacccaggctgctccagggaagacatttccctggagagttactcaagtccccagcaaa
|
84421ctttgcaggagccataaaagcaagaaataaagcatctgttgggtttagccagtgagagag
|
84481ttcctttgttgctgcagcagaacttaggctatcctgactaattcagctagtaaaagaagc
|
84541agcaggagcacttgtctgtctctctctgggatccaggtggaggacaagtctcccctgaca
|
84601atcacagccacagacctcacttcacaggagggtggggttcgaattcatactccctttgtg
|
84661ttcaaggaaactccaaaccataaaattaaagatatttcaggtatgtagtgttccgtgact
|
84721agaagcaaactcagatcccccaacctgacctcacaggattcccacaaataaagactcacc
|
84781agaacaggcagtcgaaatcccaaattcaaaccccaagaacttcaaacaaaaattactcac
|
84841tagggaatttttaaaaataattttaatgcataaagaaatgaattgagagccaaaactatg
|
84901ggcaattagcaaagtactatcaaaagtgactaaataaatttgaaagagaaccaaacagaa
|
84961ctatgaaaatcttattaacgatatgaaaacctatttggtaaaactgcagattcgaactgg
|
85021ctcaacacagaattagtgaaatgaaaggtagaattgaagcaattacccagagaatcacag
|
85081agagaaacgctgctggagaaaaaaaaaaaaaagaggtgaagaggcatcgaggcagagtga
|
85141gtagcgtgatagctaattaacgttctggaagaggacagtagaaataacagggctgggggt
|
85201gcatgcctaaagctataatggctaagaatgctccaagattgacagtagatgtgaatcttt
|
85261agattcaagaatactagtgagtttatagcaggataaataaaaatatgccttgagatatca
|
85321tagtagaactgcaggataccaaagacaaaaggaaagcatatgcttattataaattcatca
|
85381gatttattaatttgtaagagaaaaatgtatcaagcacctgctaggtgccaggcagtgttg
|
85441tagacacttgggatatatccgtccagaaagagacagaatttgtgttcattgtcaccagga
|
85501agacaggtgacaaaaaataaacataataaataagtaaattatacagtgtgttagatattg
|
85561gcaaatgctatcaattggaatatatggaaaaagaaacaaaaaaggatgaggagactctga
|
85621gtatgtgtgtggttgggagaggctgagccagggcaccatatttaataaaatgtcagggga
|
85681gttaacaaagggaagagataacctacaggataggagaaaatatttgcaaactctccatcc
|
85741aacagggggttaataagcagaatgtataaagaacgcaatagcaaataataacaatctgtt
|
85801tttaaaatggacaatagacctgaatagacatttctcaaaggaagacatacaaatggccaa
|
85861cagggatttgaaaaaatggtcaacatcactaatcatcagggaaatgcaaatcaaaaccac
|
85921aatgagacagcatctcaccccagttaaaaatggatattagcaaaaagacaaaaagtaatg
|
85981gatactggtgaggatgtggagaagaacactgttggtgggaatgtaaagtaatacagtaat
|
86041tagggaaaacagtatggaggttcctcaaaaacctacaactagaactatcacatgatctag
|
86101aaatcccactgctgggtatgtatcctaaagaaaggaaatcaatatgtcaaagtggtatcc
|
86161gcactcccatctttattacagcactattcataatagccaagatgtgggatcaacctgagt
|
86221ccatcaacagatgaatggataaagaaaatgtggtatatgtatgcaatggaatattattca
|
86281gccataaaaaggatgaaatcttgtcatttgcggcaacgtgggtggaactggaagtcatta
|
86341tgctaaatgaaataagccaggcacagaaagataaatatggcatcacatgttctcagtcgt
|
86401atgtgagagctaaaaaaagtggatttcatggggagtggaatggtggttactagagctagg
|
86461aagggcaggagggagggagagaagttggctaatgggtacaaaaatacagttagatggaag
|
86521gagtaagttctagtattcaatagtatagtacagagactatagctaacaataagttattgt
|
86581acatttcaagatagctaaaaaagaagaactggaatgttcccaacacaaagaaaagataaa
|
86641tatttgaggtgatagatattccaattactctgatttgatcattacacattgtatacagat
|
86701atccaaatatcacaggtactcccaaagtacacacagctactacatatcaatttttaatat
|
86761tacacctgaaaacaatttcaagagaggcttcattgagaaggtaaaatttgggaggggaat
|
86821tgaaggagaggaaggagttggtgagaccgagatatggaagagtgtctctcaggaagagaa
|
86881gcagctagggcatcctggcaatttgtgtatcttcatttacaaagtgtctgtccaaacctt
|
86941ttgtccaactctttaattgttgcatatattatattattgagttgtaagaatttcaaatat
|
87001attctggatataactctgtatcagatatatgtattgcaaatattttctccctgtctgtaa
|
87061cttgtcttttcgttttcttaacaggtcttttcaaatgtagacattgtttattttgatcat
|
87121gtccatttttatctatttttagttttatgcttgtgggattgttgtgttctgttaagaaat
|
87181atttgtcttcctcaatgtaacaaagtgtctagaagttttacggttttggctttgtttagg
|
87241gctgtggtccatcttaagttaatttttctgcattgtgtgaggtagggttgaagtttatat
|
87301ctttatggatgaatagctaattattccagcaacatttgtttaaaagtcttcccttttccc
|
87361aataatttagcttggcccttctttcaaaagtcaattgaaaaaatatatatcatataaaga
|
87421cttattatactatatgtatttttccagactctttattctgttccattgagctgttcttac
|
87481actaccacactaccttaattattatagctttatcatgagttttaaaattgaatactgtaa
|
87541gttcccctcactttttttaaattgctttggctattctatgcccactgcatttctatataa
|
87601attttacaatcagcttgtccatttctacaaaaaagacagatgtgattttagttgagatta
|
87661agttgaatctatggatcactgagggctgaatagacatttaacaatattgaggcttcagat
|
87721tcatgaacttggtatatctcttcgcttatttatgccttctttcatttccctcagcgatgt
|
87781tttgtagtttttagtgtacaggtcttgcacatatttgtgagatttatctctaggcatttc
|
87841ataccttttatgctattgtaaggggtattgtttttaaatatctttttatttggaggtaac
|
87901gttaaaatatcgaaagagtcacatccacagtacagagactccctgtatattattcaccca
|
87961gcttgccctcgtgctaacattctacataatcacaatctaatcatgaaaactaagaaatta
|
88021atattggtacaatactattaactcaactacagactttatctggattctactagttttcca
|
88081ctcatgttatttttcacttccaggatcccatccaggatcctacattgtatttagttggca
|
88141tatccccttagtcttctacaatctatgacagttcttcagtattcctctctttcatgactt
|
88201gaagatgctttcatggcttgatggtctgtcagatattttgtagagtgtctctcagttggg
|
88261tttggtttgatattttctcacgactattcatggtcacgctttatcaagaatactactgga
|
88321gttttgtacccttctaagtgcatcaaactaggcagttaccttatttattactggtgatgt
|
88381gagccttggtaacttggtaaagagagtatctgtcctattccttcactgtacagttactat
|
88441ttttctttttgtaattagtaactcttgggaaagatactttgagactgtgcaaatgtcctg
|
88501tttgttaaacttttgcccactaattttagtatttggtgtttaacttgcctccagcaatta
|
88561ttgctgtggaatttcaatgatttttctattttcctcatttcttctacatttgttaatagg
|
88621aattcttctttaatgaggtgttgttccttttctcccatttatttattgatacttataatt
|
88681taatattatatattgcacattatttttataatgtaaaatataaaaattatatatttatta
|
88741tgtatatgtgtgtgtgtatatatgtaaaataacctgaggaaaagattttattattttggt
|
88801tataatccaatattattactatttattttgttgctcaaattgttccagctttggccattg
|
88861ggagctctttcaaattggttcctgtgtcctttcagtacccatgatccttttggtttttga
|
88921gtatatggtttatcatatggtattattttttatttcaatcaccaactgttctttgttagt
|
88981atatagacatgcaatttatttatgcatatttaaaatgagtttcttacagacaacaggaaa
|
89041gtgaaccttgtttttttatccagtgtcacaatctctgccttttattggagagtttagact
|
89101tttacgtttaatacaattaatcagtatcattggatttaagtttaccatctagctatttgt
|
89161tttttatttatcctatctgctctctgttcctttttctcttttttccttgcttctttaagt
|
89221ttaattgagtatgtttttaggattttatttcttcactagtatctaacaaactatctcttt
|
89281gttctaatttttagtgtttgctccattatttaaaatatacatatttaatttatcacaatc
|
89341taccttcaattgatattatattatcacttcatgtatgatgtcatattcctgctacagtat
|
89401atttcaatcttaccccacccatccttcatgtttttgttgtcatagatattactttttaat
|
89461atatcgtaagcccaaagtacatggttgacattctgtttaaaacagtcaattgtcttttaa
|
89521agacattaaaaagcgagaaaaaagtcttttaatagatatttttaaatgcatgtagcacaa
|
89581taatgtaaacagttcatgtaaaacaccaatttataatattctatatatatatatatatat
|
89641atatatatatatatatatatatatatatatatatatatatatagtttccttcaggtaata
|
89701ggttggaagggtttagaataaaatgaacatgcatcacatctgttattttaaaatatttaa
|
89761tcaagtttttaaaatgtttatgaaccaccagaatgccactgccacaaatatcattaccaa
|
89821taaccagtcttttttttttttttttttttgtgagacaggatctcactctgtcacccaggc
|
89881tggagtacagtggcatgatcatggctcattgcagccttgactttcgcagactcagatgat
|
89941actcccacctcaacctcctaagtatctgggactacaggcaggcacaccaccatgctctgc
|
90001tattttttactttattttattttatgtatttttgtagagatggggttttgccatgttgcc
|
90061caggctagtctggaacttccgggttcaagcaatctgcccagctcagcctcccaaagcgtt
|
90121aggataacaggtgtgaaccaccacactgcctacaaataaccattctttaagtgggctttt
|
90181atttgtttaaaaaacttttttgtgtttatctacataattgccattctcacagtcttcatt
|
90241ccttttcagagagccgggtttctatctggtattgttttctttatgcttgaagaacgttct
|
90301ttaacatttctggtagtacaagtctgatgacgtcttaaaatgtttattttgccttcattt
|
90361ttaaaagatattttcgtaggatacagagttctagattaacagcttctttcttgcacttct
|
90421tttgagatgttaccccattgacttctggcttacattgtttccaaaaagaatactgttttc
|
90481attttcaccatgttcctgtgtatgttacacgtctcatttttctctggctgcttctaggat
|
90541tttctccttaacgccggtttcagaaaactgcttatgatgtggcttgctgtggttttcttt
|
90601gtatttatcctgcttggtcttcattgcacttcttggatttatagatttatggttttcttc
|
90661aaatttggaaatttttcatccattatatcttaaaacattttttgtcctctccttgctttc
|
90721gaagacttcaatttttccataccttagatgacttactattgccccatagtcactgcgaat
|
90781ctgtttattgttttccagtctcttttctctgtgtgctgtgtctcagatcacttatagaac
|
90841tatgtcttcaagttcactagtctttgaaccagctgtcaagcttatccagtgaaatttgca
|
90901ttttagacatagctctaccagttccacatagtttctttttatatcttccatttattttct
|
90961cactatggttatcttttcatttaagtacttgaacatagttataataattgtttttaacat
|
91021tgttgcccggcatttccgttgttcgtatcatcctttggtctgtttctattgacggcctta
|
91081ttccctggctgtggttcacattttctggctttttggcacatggattttgatcagatgctg
|
91141aatgttgtgaatgtttcattgttgagtgtctgtaatttgccatcctcttttaaggagctt
|
91201tggggtttgtcctgcttggcagtttagttacttccagttcagttacacactttctaggct
|
91261cgtttttagctttataggacaggtctagWggatcctttgttctagagatagtttgggccc
|
91321actgctaaagtgtggctcttctaaggtgtctaccgaatgcccggtgatcagcaagaagga
|
91381attctgaactgcaattgcaattgagaacttgaacgatcccatctccacatggactttatg
|
91441aacgaacagttcaacgcagctccagtgaattactctttgactgacctggtgagttttacc
|
91501tgactcaggctttttttttttttttttttggtattcagcaaagattaaagaggacccctt
|
91561tgctcctattctgtagctcttttttgcaaagatctttcctttttgtaagtatgacccccg
|
91621gcttttggtgacccccctggagaagcctcagtgctctgcttagcttcccacccccacccc
|
91681gagtcccacacagcagcatggaaacctccaagcagaaagtcaggcaaagaaagggctcct
|
91741tcctatctcccgcttatctcctcctgggagcgcagttgtttgtctctcttgcccaRtgta
|
91801aagaggaaggtcagtgcagcccctgttgctccatcatcatggttgggagcagacatctgt
|
91861cccaccacatggttttgagctgacaattgaaaagaaactgacaattgaaaagaaacactc
|
91921tggcttctgaactgagaacagacaataggagtgcaagggcagaagcaaggagacttccta
|
91981gggggctatcgcatcacagccatccagaaaatgaatggttgggttcaaaatgaatggtaa
|
92041cattttgaatgcaaagcttacagaaatccctgatagattggatgtaaggaaacaagacac
|
92101tttgggaggccgaggcgggcggatcacgaggtcaggagatcgagaccatcctggctaaca
|
92161tggtgaaaccctatctccactaaaaacacaaaaaattagccaggcgtggtgggggacgct
|
92221tgtagtccaagctactcaggaggctgaggcaggagaatggcatgaacccgggaggcggag
|
92281cttgcagtgaggcgagatcgtaccactgcactccagcctgggtgacagagcgagactcca
|
92341taaaaaaaaaaaagaaagaaagaaagaaagagagagagagagagagagagagagagaaag
|
92401aaagaaagaaagaaagaaagaaagaaagaaagaaagaaagaaagaaagaaagaaagaaaa
|
92461gaaagaaagaaagaaggaaggaaggaaaggagaaaggaaggaaggaaggaaggagaaaag
|
92521aagaaaaaagtcaagatgatacaaggtttgggtctgagcaactagaataatctcgttgcc
|
92581atccattgagatgctgcagtctgtgggtggaacacgtctggggctattggggaattgttt
|
92641ggaggcatgagcttaaatgtctacgaggcacacacacgtggaaatgtcaagctgggactt
|
92701taaatatacaattcctgagcttgtgcagagtttagggttggagatataaatttggggtga
|
92761gtgtaggataaagagaaagaacaaaatctaacactgagaggctggggcatggaggaccag
|
92821gagggctcaaaggagacagaaggagcagtcaaggaggagtcaaggaggagtcaagggccg
|
92881aggaccaggagggctttgagtcctgaagcagaacagtgcatgtcagaaaggaggatggac
|
92941tgcagcagctttgtaggtcaagaagaacagggcatagtagacaaccgctgggtctgacag
|
93001cgtggtggtccctggtagaatcatgtcgctaagagcctgactttggggtaaagaaaaagg
|
93061aggaaaaggaatgggagacagagactacagacttactccttaatgaagctgtgctctaca
|
93121aagaggagaaaaattgggacggtagctagcatgggaatatccaatgactgatccacgtgg
|
93181atgcaaacgcctgccccctggcctcaattcaggacaccttggcatggccaccccaagtcc
|
93241agggatctctgtgggctccgccaagattctggttgcagctgtactactgttgaactcctc
|
93301cggctgctcaatcctgctcctctctctccccagcaagtacacacaactccgagttgaacc
|
93361ccacccaagacacttcccttccccgcacccccaaataaaccacttccattggaatcctgt
|
93421ctcagaatctgtttctggggaacccaaacttagcccaacagcaggtctcaaggctgacag
|
93481gaatgtgggaaattgagggaaagtgtgggaaccagaggaagatgggctgtgggatgccac
|
93541taagcaggtgggggggcctggatccagcgcacaaggcgagggcctgccttaggaaagggg
|
93601cttgtcacttgcagcacttggtgcaggattcaggtaggtggcatctgcagaagatccctt
|
93661ctgaataattctattttgtcagtgaaccagaagcaaggttactactaagcatgaagactg
|
93721gggagaagtggggtttggagaagaaaggagactggtttgggSgcggggggttgcagggaS
|
93781gaaagtgaacagactagacagtgagtcacaggacaactgcgggaggacatcctcaaggtg
|
93841cctaagaaaacaatagtcaatctggacatatacctggtgaaactgtatttcaaggagaaa
|
93901ggtaaaataaagatatttttagataaacacaaaaggagagactgtcccaccaacaactct
|
93961cacaaaaggacttttgaaatggatgcatttcaggaagaaagaaagtgatcccagacggaa
|
94021gatctgggcaggaaaaaggagtgagaatcttacagaaggagacagggagttgtggatcca
|
94081tcaggcctgaaatgtgatggtcagttggtcagtttttgtgagtcaacatattgctctttt
|
94141ttctctctctttttttttttttttttttttggattggtgaggtctggctatgttgcccag
|
94201gctggtcccgaacccctgagttcaagcgatcctcccacctcKgcctcccaaagtgctggg
|
94261attacaggcatgggccaccacgcctggctcaacacattgctctctaatgttattgttgct
|
94321tgccccaagttccgtggagtcttctatcacttgcagctgagcaccctgacggatctacgc
|
94381agccacttgagagcgcgctttgccgcgtgcttggcgagaaggcgccaatcaaccctttaa
|
94441tccaatcatgcaatgattagggccttccaggtggaggtggagctgaggtccttccgggag
|
94501agagaaaaagcctcacagcaggcttactcctataaggtgacacagacacaatctcgtcac
|
94561aggatgaggagtagggaaatctcccaacttgggcacacagcgtgtgatctcgccttgctt
|
94621ttctccctggaggtgcagcatcatcacaggtgttggatggacagctggcaaccaatgtaa
|
94681atgcctgtttccccagctctaataaacgggcttaacagcacatgccctcgtgcaccttag
|
94741gaagccacatgtattgcagctgggccactgggaaaaggcacttctttctttcagaataag
|
94801ggccaactRatgtatYatgaatgacccaacaaccctacctcttaaaacgctgtctgagag
|
94861cctgagcaaactggacctcgccagtggctggtgagagctctgtgttaatggtgctggatt
|
94921cctgcgggggcctgtgattccccgctccgtagagagtaggacagcaccccgcctcctccg
|
94981gacattgctgcacagtgggtgagccacctgctgccctgaacaggaagggaaggaggagcc
|
95041gtcggagctt
Following are ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 complementary DNA sequences (cDNAs; SEQ ID NO: 8, 9, 10, 11, 12, 13, 14, 15, 16 and 17, respectively). Following is an ICAM1 cDNA sequence (SEQ ID NO: 8).
|
|
NM_000201 [gi:4557877] Homo sapiens intercellular adhesion molecule 1 (CD54),
human rhinovirus receptor (ICAM1), mRNA
|
|
gcgccccagtcgacgctgagctcctctgctactcagagttgcaacctcagcctcgctatggctcccagcagcccccg
|
gcccgcgctgcccgcactcctggtcctgctcggggctctgttcccaggacctggcaatgcccagacatctgtgtccc
|
cctcaaaagtcatcctgccccggggaggctccgtgctggtgacatgcagcacctcctgtgaccagcccaagttgttg
|
ggcatagagaccccgttgcctaaaaaggagttgctcctgcctgggaacaaccggaaggtgtatgaactgagcaatgt
|
gcaagaagatagccaaccaatgtgctattcaaactgccctgatgggcagtcaacagctaaaaccttcctcaccgtgt
|
actggactccagaacgggtggaactggcacccctcccctcttggcagccagtgggcaagaaccttaccctacgctgc
|
caggtggagggtggggcaccccgggccaacctcaccgtggtgctgctccgtggggagaaggagctgaaacgggagcc
|
agctgtgggggagcccgctgaggtcacgaccacggtgctggtgaggagagatcaccatggagccaatttctcgtgcc
|
gcactgaactggacctgcggccccaagggctggagctgtttgagaacacctcggccccctaccagctccagaccttt
|
gtcctgccagcgactcccccacaacttgtcagcccccgggtcctagaggtggacacgcaggggaccgtggtctgttc
|
cctggacgggctgttcccagtctcggaggcccaggtccacctggcactgggggaccagaggttgaaccccacagtca
|
cctatggcaacgactccttctcggccaaggcctcagtcagtgtgaccgcagaggacgagggcacccagcggctgacg
|
tgtgcagtaatactggggaaccagagccaggagacactgcagacagtgaccatctacagctttccggcgcccaacgt
|
gattctgacgaagccagaggtctcagaagggaccgaggtgacagtgaagtgtgaggcccaccctagagccaaggtga
|
cgctgaatggggttccagcccagccactgggcccgagggcccagctcctgctgaaggccaccccagaggacaacggg
|
cgcagcttctcctgctctgcaaccctggaggtggccggccagcttatacacaagaaccagacccgggagcttcgtgt
|
cctgtatggcccccgactggacgagagggattgtccgggaaactggacgtggccagaaaattcccagcagactccaa
|
tgtgccaggcttgggggaacccattgcccgagctcaagtgtctaaaggatggcactttcccactgcccatcggggaa
|
tcagtgactgtcactcgagatcttgagggcacctacctctgtcgggccaggagcactcaaggggaggtcacccgcga
|
ggtgaccgtgaatgtgctctccccccggtatgagattgtcatcatcactgtggtagcagccgcagtcataatgggca
|
ctgcaggcctcagcacgtacctctataaccgccagcggaagatcaagaaatacagactacaacaggcccaaaaaggg
|
acccccatgaaaccgaacacacaagccacgcctccctgaacctatcccgggacagggcctcttcctcggccttccca
|
tattggtggcagtggtgccacactgaacagagtggaagacatatgccatgcagctacacctaccggccctgggacgc
|
cggaggacagggcattgtcctcagtcagatacaacagcatttggggccatggtacctgcacacctaaaacactaggc
|
cacgcatctgatctgtagtcacatgactaagccaagaggaaggagcaagactcaagacatgattgatggatgttaaa
|
gtctagcctgatgagaggggaagtggtgggggagacatagccccaccatgaggacatacaactgggaaatactgaaa
|
cttgctgcctattgggtatgctgaggcccacagacttacagaagaagtggccctccatagacatgtgtagcatcaaa
|
acacaaaggcccacacttcctgacggatgccagcttgggcactgctgtctactgaccccaacccttgatgatatgta
|
tttattcatttgttattttaccagctatttattgagtgtcttttatgtaggctaaatgaacataggtctctggcctc
|
acggagctcccagtccatgtcacattcaaggtcaccaggtacagttgtacaggttgtacactgcaggagagtgcctg
|
gcaaaaagatcaaatggggctgggacttctcattggccaacctgcctttccccagaaggagtgatttttctatcggc
|
acaaaagcactatatggactggtaatggttcacaggttcagagattacccagtgaggccttattcctcccttccccc
|
caaaactgacacctttgttagccacctccccacccacatacatttctgccagtgttcacaatgacactcagcggtca
|
tgtctggacatgagtgcccagggaatatgcccaagctatgccttgtcctcttgtcctgtttgcatttcactgggagc
|
ttgcactattgcagctccagtttcctgcagtgatcagggtcctgcaagcagtggggaagggggccaaggtattggag
|
gactccctcccagctttggaagggtcatccgcgtgtgtgtgtgtgtgtatgtgtagacaagctctcgctctgtcacc
|
caggctggagtgcagtggtgcaatcatggttcactgcagtcttgaccttttgggctcaagtgatcctcccacctcag
|
cctcctgagtagctgggaccataggctcacaacaccacacctggcaaatttgattttttttttttttttcagagacg
|
gggtctcgcaacattgcccagacttcctttgtgttagttaataaagctttctcaactgcc
|
Following is an ICAM4 cDNA sequence (SEQ ID NO: 9).
|
|
NM_001544 [gi:12545400] Homo sapiens intercellular adhesion molecule 4,
Landsteiner-Wiener blood group (ICAM4), transcript variant 1, mRNA.
|
|
ctttttgccatggggtctctgttccctctgtcgctgctgttttttttggcggccgcctacccgggagttgggagcgc
|
gctgggacgccggactaagcgggcgcaaagccccaagggtagccctctcgcgccctccgggacctcagtgcccttct
|
gggtgcgcatgagcccggagttcgtggctgtgcagccggggaagtcagtgcagctcaattgcagcaacagctgtccc
|
cagccgcagaattccagcctccgcaccccgctgcggcaaggcaagacgctcagagggccgggttgggtgtcttacca
|
gctgctcgacgtgagggcctggagctccctcgcgcactgcctcgtgacctgcgcaggaaaaacacgctgggccacct
|
ccaggatcaccgcctacaaaccgccccacagcgtgattttggagcctccggtcttaaagggcaggaaatacactttg
|
cgctgccacgtgacgcaggtgttcccggtgggctacttggtggtgaccctgaggcatggaagccgggtcatctattc
|
cgaaagcctggagcgcttcaccggcctggatctggccaacgtgaccttgacctacgagtttgctgctggaccccgcg
|
acttctggcagcccgtgatctgccacgcgcgcctcaatctcgacggcctggtggtccgcaacagctcggcacccatt
|
acactgatgctcgcttggagccccgcgcccacagctttggcctccggttccatcgctgcccttgtagggatcctcct
|
cactgtgggcgctgcgtacctatgcaagtgcctagctatgaagtcccaggcgtaaagggggatgttctatgccggct
|
gagcgagaaaaagaggaatatgaaacaatctggggaaatggccatacatggtggctgacgcctgtaatcccagcact
|
ttgggaggccgaggcaggagaatcgcttgagcccaggagttcgagaccagcctggacaacatagtgagaccccgtct
|
atgcaaaaaatacacaaattagcctggtgtggtggcccgcacctgtggtcccagctacccgggaggctgagttggga
|
ggatcctttgagccctgaaagtcgaggttgcagtgagccttgatcgtgccactgcactccagcctgggggacagagc
|
acgaccctgtctccaaaaataaaataaaaataaaaataaatattggcgggggaaccctctggaatcaataaaggctt
|
ccttaaccagc
|
Following is an ICAM5 cDNA sequence (SEQ ID NO: 10).
|
|
NM_003259 [gi:12545403] Homo sapiens intercellular adhesion molecule 5,
telencephalin (ICAM5), mRNA
|
|
ccgtcctctagcccagctcctcggctcgcgctctcctcgcctcctgtgctttccccgccgcggcgatgccagggcct
|
tcgccagggctgcgccgggcgctactcggcctctgggctgctctgggcctggggctcttcggcctctcagcggtctc
|
gcaggagcccttctgggcggacctgcagcctcgcgtggcgttcgtggagcgcgggggctcgctgtggctgaattgca
|
gcaccaactgccctcggccggagcgcggtggcctggagacctcgctgcgccgaaacgggacccagaggggtttgcgt
|
tggttggcgcggcagctggtggacattcgcgagccggagactcagcccgtctgcttcttccgctgcgcgcggcgcac
|
actacaggcgcgtgggctcattcgcactttccagcgaccagatcgcgtagagctgatgccgctgcctccctggcagc
|
cggtgggcgagaacttcaccctgagctgtagggtccccggcgccgggccccgtgcgagcctcacgctgaccctgctg
|
cggggcgcccaggagctgatccgccgcagcttcgccggtgaaccaccccgagcgcggggcgcggtgctcacagccac
|
ggtactggctcggagggaggaccatggagccaatttctcgtgtcgcgccgagctggacctgcggccgcacggactgg
|
gactgtttgaaaacagctcggcccccagagagctccgaaccttctccctgtctccggatgccccgcgcctcgctgct
|
ccccggctcttggaagttggctcggaaaggcccgtgagctgcactctggacggactgtttccagcctcagaggccag
|
ggtctacctcgcactgggggaccagaatctgagtcctgatgtcaccctcgaaggggacgcattcgtggccactgcca
|
cagccacagctagcgcagagcaggagggtgccaggcagctgatctgcaacgtcaccctggggggcgaaaaccgggag
|
acccgggagaacgtgaccatctacagcttcccggcaccactcctgaccctgagcgaacccagcgtctccgaggggca
|
gatggtgacagtaacctgcgcagctgggacccaagctctggtcacactggagggagttccagccgcggtcccggggc
|
agcccgcccagcttcagctaaatgccaccgagaacgacgacagacgcagcttcttctgcgacgccaccctcgatgtg
|
gacggggagaccctgatcaagaacaggagcgcagagcttcgtgtcctatacgctccccggctagacgattcggactg
|
ccccaggagttggacgtggcccgagggcccagagcagacgctgcgctgcgaggcccgcgggaacccagaaccctcag
|
tgcactgtgcgcgctccgacggcggggccgtgctggctctgggcctgctgggtccagtcactcgggcgctctcaggc
|
acttaccgctgcaaggcggccaatgatcaaggcgaggcggtcaaggacgtaacgctaacggtggagtacgcaccagc
|
gctggacagcgtgggctgcccagaacgcattacttggctggagggaacagaagcctcgctgagctgtgtggcgcacg
|
gggtaccgccgcctgatgtgatctgcgtgcgctctggagaactcggggccgtcatcgaggggctgttgcgtgtggcc
|
cgggagcatgcgggcacttaccgctgcgaagccaccaaccctcggggctctgcggccaaaaatgtggccgtcacggt
|
ggaatatggccccaggtttgaggagccgagctgccccagcaattggacatgggtggaaggatctgggcgcctgtttt
|
cctgtgaggtcgatgggaagccacagccaagcgtgaagtgcgtgggctccgggggcgccactgagggggtgctgctg
|
ccgctggcacccccagaccctagtcccagagctcccagaatccctagagtcctggcacccggtatctacgtctgcaa
|
cgccaccaaccgccacggctccgtggccaaaacagtcgtcgtgagcgcggagtcgccaccggagatggatgaatcta
|
cctgcccaagtcaccagacgtggctggaaggggctgaggcttccgcgctggcctgcgccgcccggggtcgcccttcc
|
ccaggagtgcgctgctctcgggaaggcatcccatggcctgagcagcagcgcgtgtcccgagaggacgcgggcactta
|
ccactgtgtggccaccaatgcgcatggcacggactcccggaccgtcactgtgggcgtggaataccggccagtggtgg
|
ccgaacttgctgcctcgccccctggaggcgtgcgcccaggaggaaacttcacgttgacctgccgcgcggaggcctgg
|
cctccagcccagatcagctggcgcgcgcccccgggggccctcaacatcggcctgtcgagcaacaacagcacactgag
|
cgtggcaggcgccatgggaagccacggcggcgagtacgagtgcgcacgcaccaacgcgcacgggcgccacgcgcggc
|
gcatcacggtgcgcgtggccggtccgtggctatgggtcgccgtgggcggcgcggcggggggcgcggcgctgctggcc
|
gcgggggccggcctggccttctacgtgcagtccaccgcctgcaagaagggcgagtacaacgtgcaggaggccgagag
|
ctcaggcgaggccgtgtgtctcaacggagcgggcggcggcgctggcggggcggcaggcgcggagggcggacccgagg
|
cggcggggggcgcggccgagtcgccggcggagggcgaggtcttcgccatacagctgacatcggcgtgagccgctccc
|
ctctccccgcgggccgggggacgccccccagactcacaogggggcttatttattgctttatttatttacttattcat
|
ttatttatgtattcaactccaagggcgtcacccccattttctacccatcccctcaataaagtttttataaagga
|
Following is a MAPK10 cDNA sequence (SEQ ID NO: 11).
|
|
NM_003259 [gi:12545403] Homo sapiens mitogen-activated protein kinase 10
(MAPK10), transcript variant 1, mRNA.
|
|
gagaaatggcgtggcaggggacccagcgagcccagagggattttgccgctgcttcctctacccctgtatttcacgca
|
gctctctaaattgactcagctccaggctagtgtgagaaacaccaacagcaggcccatctcagatcttcactatggca
|
acttatgcaagaaactgttgaattagacccgtttcctatagatgagaaaccatacaagctgtggtatttatgagcct
|
ccatttcttatactactgcagtgaaccaacattggatgtgaaaattgccttttgtcagggattcgataaacaagtgg
|
atgtgtcatatattgccaaacattacaacatgagcaaaagcaaagttgacaaccagttctacagtgtggaagtggga
|
gactcaaccttcacagttctcaagcgctaccagaatctaaagcctattggctctggggctcagggcatagtttgtgc
|
cgcgtatgatgctgtccttgacagaaatgtggccattaagaagctcagcagaccctttcagaaccaaacacatgcca
|
agagagcgtaccgggagctggtcctcatgaagtgtgtgaaccataaaaacattattagtttattaaatgtcttcaca
|
ccccagaaaacgctggaggagttccaagatgtttacttagtaatggaactgatggatgccaacttatgtcaagtgat
|
tcagatggaattagaccatgagcgaatgtcttacctgctgtaccaaatgttgtgtggcattaagcacctccattctg
|
ctggaattattcacagggatttaaaaccaagtaacattgtagtcaagtctgattgcacattgaaaatcctggacttt
|
ggactggccaggacagcaggcacaagcttcatgatgactccatatgtggtgacacgttattacagagcccctgaggt
|
catcctggggatgggctacaaggagaacgtggatatatggtctgtgggatgcattatgggagaaatggttcgccaca
|
aaatcctctttccaggaagggactatattgaccagtggaataaggtaattgaacaactaggaacaccatgtccagaa
|
ttcatgaagaaattgcaacccacagtaagaaactatgtggagaatcggcccaagtatgcgggactcaccttccccaa
|
actcttcccagattccctcttcccagcggactccgagcacaataaactcaaagccagccaagccagggacttgttgt
|
caaagatgctagtgattgacccagcaaaaagaatatcagtggacgacgccttacagcatccctacatcaacgtctgg
|
tatgacccagccgaagtggaggcgcctccacctcagatatatgacaagcagttggatgaaagagaacacacaattga
|
agaatggaaagaacttatctacaaggaagtaatgaattcagaagaaaagactaaaaatggtgtagtaaaaggacagc
|
cttctccttcagcacaggtgcagcagtgaacagcagtgagagtctccctccatcctcgtctgtcaatgacatctcct
|
ccatgtccaccgaccagaccctggcatctgacactgacagcagcctggaagcctcggcaggacccctgggttgttgc
|
aggtgactagccgcctgcctgcgaaacccagcgttcttcaggagatgatgtgatggaacacacacacacgcagacac
|
acacacacacacaaatgcagacacacaacatcaagaaaacagcaagggagagaatccaagcctaaaattaaataaat
|
ctttcagcctgcttcttccccagggttctgtattgcagctaagctcaaatgtatatttaacttctagttgctcttgc
|
tttggtcttcttccaatgatgcttactacagaaagcaaatcagacacaattagagaagccttttccataaagtgtaa
|
ttttaatggctgcaaaaccggcaacctgtaactgcccttttaaatggcatgacaaggtgtgcagtggccccatccag
|
catgtgtgtgtctctatcttgcatctacctgctccttggcctagtcagatggatgtagatacagatccgcatgtgtc
|
tgtattcatacagcactacttacttagagatgctactgtcagtgtcctcagggctctaccaagacataatgcactgg
|
ggtaccacatggtccatttcatgtgatctattactctgacataaacccatctgtaatatattgccagtatataagct
|
gtttagtttgttaattgattaaactgtatgtcttataagaaaacatgtaaagggggaatatatggggggagtgagct
|
ctctcagacccttgaagatgtagcttccaaatttgaatggattaaatggcacctgtatacca
|
Other isoforms are isoform 2 (NM_138982); isoform 3 (NM_138980); isoform 4
(NM_138981)
|
Following is a first KIAA0861 cDNA sequence (SEQ ID NO: 12).
|
|
KIAA0861 Coding Seguence (cDNA) Corresponding to SEQ ID NO:2. (cDNA from
positions 94 . . . 3189)
|
|
cgctgaattctaggggaggatggcgcccccatcatcacgttcccagagttttcggggttcaaacacatcccagatga
|
agacttcctgaatgtcatgacctacctgactagcatccccagtgtggaggctgccagcattggattcattgttgtta
|
tcgacagacgaagagacaagtggagctccgtaaaggcatccttgacacgaatagctgtggcatttccaggaaactta
|
cagctcatattcatccttcgtccatctcgctttatccagaggacattcactgacattggcattaaatactatcgaaa
|
tgagtttaaaacgaaagtgccgatcatcatggtaaactctgtctctgaccttcacggctacatcgacaaaagccaac
|
tgacccgggaattaggggggactttggaatatcgccacggtcagtgggtaaatcaccgcactgccatcgaaaacttt
|
gccttgaccttgaagaccactgcccagatgctgcagacgtttgggtcctgcctggccacagcagagctgcccagaag
|
catgctatccacggaagaccttctcatgtcccacacaaggcagcgggacaagctgcaggatgagctgaaattacttg
|
gaaagcaggggaccacattgctgtcatgcatccaagaaccagcaaccaaatgtcccaacagcaaactcaatctcaac
|
caacttgagaatgtaactaccatggaaaggttattagttcaactggatgaaacagaaaaagcctttagtcacttttg
|
gtctgagcatcatctgaagcttaaccagtgcctacaactacagcattttgagcacgatttttgtaaggctaagcttg
|
ccctggataatttgctggaagagcaagcagagtttacaggcattggagacagcgtgatgcacgtggagcagattctt
|
aaggaacacaaaaaactggaggaaaaaagccaggagtccctggaaaaggcccagctgctggcactggttggggacca
|
gctcatccaaagccaccattatgcagcagatgccatcaggccccggtgtgtggagctcaggcacctctgtgacgatt
|
tcatcaatggaaacaagaaaaaatgggacattttaggaaagtccttagagtttcatagacagctggacaaggtcagc
|
caatggtgtgaggcaggaatctacctcttggcttcccaagctgtagacaagtgccagtctcgagaaggggttgatat
|
cgccttgaacgacattgcgacattcctgggcacagtcaaggagtacccgttgctcagccccaaggagttttacaacg
|
agtttgagttgctgctcaccctcgatgcaaaggccaaagcccagaaagttttgcagaggctggatgatgtccaggaa
|
atatttcacaagaggcaagtgagtctgatgaaactggcagccaaacagactcgtccagtgcaacctgtggccccaca
|
tcctgagtcttcaccaaaatgggtgtcatcaaaaaccagccagccctccacctcggtccctctagctcgtcctctga
|
gaacgtctgaggaaccttatacggagacagagttgaactcccggggaaaggaagatgatgagactaaatttgaagtc
|
aagagtgaagaaatctttgaaagccatcatgaaagggggaaccctgagctggagcagcaggccaggctcggagacct
|
ttccccccgcaggcgcattatacgtgacttgcttgagactgaagagatttacataaaagagattaaaagcataattg
|
atggatatatcactccaatggattttatttggctaaagcatctaattccagatgttcttcagaataacaaggacttt
|
ctctttgggaatattagagaactttacgaatttcacaacaggacttttctaaaagagttggaaaagtgtgctgagaa
|
ccctgaacttctggcacattgctttctcaagagaaaagaagatcttcagatatattttaaataccataagaatctgc
|
cccgagctagggcaatctggcaagagtgtcaagactgcgcctactttggggtatgccagcgccaactggatcacaat
|
ctccctctttttaagtatctcaaaggaccaagccagagacttataaaataccagatgctgttgaagggtctgctgga
|
tttcgagtctcctgaagatatggagatagacccaggtgaactaggaggctcggctaaggatgggccaaagagaacca
|
aagattcagcattctcaactgaactacaacaagctttggcagtgatagaggatttgatcaagtcctgtgagttggct
|
gtggacctagcagcagtgactgaatgtccggacgatattggaaaactaggcaagctgttgctgcacggccctttcag
|
cgtctggacaattcacaaggatcgttataaaatgaaggatttgattcgatttaaacccagccagaggcaaatctacc
|
tatttgaaaggggaatagtgttctgtaagatacgaatggagcctggggaccagggattatctcctcattacagcttc
|
aagaaggccatgaagctgatgacactttcaattcgccagcttggaagggggagccatagaaagtttgagattgccag
|
tcgaaatggacttgagaaatacatcctgcaggcagcttcaaaagaaatcagagactgttggttttcagaaataagta
|
aattattgatggaacaacaaaataatatcaaagaccaaggaaatccacagtttgaaatgagcacgagcaaaggcagt
|
ggagcaggatccggaccatggattaaaaatatggaaagagctaccactagcaaggaagacccggcctccagcacagg
|
agggattaaaggctgctccagcagggagtttagctccatggacacctttgaagactgtgaaggcgcagaagacatgg
|
aaaaggagagcagtgctctgagtctcgcgggccttttccagtcggacgacagtcacgaaacctgttcctccaaatct
|
gctttcctggagaggggagaaagcagccagggagaaaaagaagaacgcgatgaggaggaaacggcgacccgcagcac
|
cgaggaggagcgcgctggggcgtccacgggccggctggctcctgcgggggcgacggctggtttccaggcgagggcgc
|
tgcgcccgaggacctccgcccaggagagctga
|
Following is a second KIAA0861 cDNA sequence (SEQ ID NO: 13).
|
(4772 bp)
ttgggcggagatgcctttaaaaaatcatccaccgcagcggtagaaacagttttgtttggctttatttatacggaatg
|
gtttttcagtgaaatgctgtcttgcttaaaagaagagatgcctccccaggagctcacccggcgactggccacagtga
|
tcactcatgtcgatgaaattatgcagcaggaagtcagacccctgatggcggtggagataatagaacaacttcacaga
|
caatttgccattctttcaggaggccgaggggaggatggcgcccccatcatcacgttcccagagttttcggggttcaa
|
acacatcccagatgaagacttcctgaatgtcatgacctacctgactagcatccccagtgtggaggctgccagcattg
|
gattcattgttgttatcgacagacgaagagacaagtggagctccgtaaaggcatccttgacacgaatagctgtggca
|
tttccaggaaacttacagctcatattcatccttcgtccatctcgctttatccagaggacattcactgacattggcat
|
taaatactatcgaaatgagtttaaaacgaaagtgccgatcatcatggtaaactctgtctctgaccttcacggctaca
|
tcgacaaaagccaactgacccgggaattaggggggactttggaatatcgccacggtcagtgggtaaatcaccgcact
|
gccatcgaaaactttgccttgaccttgaagaccactgcccagatgctgcagacgtttgggtcctgcctggccacagc
|
agagctgcccagaagcatgctatccacggaagaccttctcatgtcccacacaaggcagcgggacaagctgcaggatg
|
agctgaaattacttggaaagcaggggaccacattgctgtcatgcatccaagaaccagcaaccaaatgtcccaacagc
|
aaactcaatctcaaccaacttgagaatgtaactaccatggaaaggttattagttcaactggatgaaacagaaaaagc
|
ctttagtcacttttggtctgagcatcatctgaagcttaaccagtgcctacaactacagcattttgagcacgattttt
|
gtaaggctaagcttgccctggataatttgctggaagagcaagcagagtttacaggcattggagacagcgtgatgcac
|
gtggagcagattcttaaggaacacaaaaaactggaggaaaaaagccaggagcccctggaaaaggcccagctgctggc
|
actggttggggaccagctcatccaaagccaccattatgcagcagatgccatcaggccccggtgtgtggagctcaggc
|
acctctgtgacgatttcatcaatggaaacaagaaaaaatgggacattttaggaaagtccttagagtttcatagacag
|
ctggacaaggtcagccaatggtgtgaggcaggaatctacctcttggcttcccaagctgtagacaagtgccagtctcg
|
agaaggggttgatatcgccttgaacgacattgcgacattcctgggcacagtcaaggagtacccgttgctcagcccca
|
aggagttttacaacgagtttgagttgctgctcaccctcgatgcaaaggccaaagcccagaaagttttgcagaggctg
|
gatgatgtccaggaaatatttcacaagaggcaagtgagtctgatgaaactggcagccaaacagactcgtccagtgca
|
acctgtggccccacatcctgagtcttcaccaaaatgggtgtcatcaaaaaccagccagccctccacctcggtccctc
|
tagctcgtcctctgagaacgtctgaggaaccttatacggagacagagttgaactcccggggaaaggaagatgatgag
|
actaaatttgaagtcaagagtgaagaaatctttgaaagccatcatgaaagggggaaccctgagctggagcagcaggc
|
caggctcggagacctttccccccgcaggcgcattatacgtgacttgcttgagactgaagagatttacataaaagaga
|
ttaaaagcataattgatggatatatcactccaatggattttatttggctaaagcatctaattccagatgttcttcag
|
aataacaaggactttctctttgggaatattagagaactttacgaatttcacaacaggacttttctaaaagagttgga
|
aaagtgtgctgagaaccctgaacttctggcacattgctttctcaagagaaaagaagatcttcagatatattttaaat
|
accataagaatctgccccgagctagggcaatctggcaagagtgtcaagactgcgcctactttggggtatgccagcgc
|
caactggatcacaatctccctctttttaagtatctcaaaggaccaagccagagacttataaaataccagatgctgtt
|
gaagggtctgctggatttcgagtctcctgaagatatggagatagacccaggtgaactaggaggctcggctaaggatg
|
ggccaaagagaaccaaagattcagcattctcaactgaactacaacaagctttggcagtgatagaggatttgatcaag
|
tcctgtgagttggctgtggacctagcagcagtgactgaatgtccggacgatattggaaaactaggcaagctgttgct
|
gcacggccctttcagcgtctggacaattcacaaggatcgttataaaatgaaggatttgattcgatttaaacccagcc
|
agaggcaaatctacctatttgaaaggggaatagtgttctgtaagatacgaatggagcctggggaccagggattatct
|
cctcattacagcttcaagaagaccatgaagctgatgacactttcaattcgccagcttggaagggggagccatagaaa
|
gtttgagattgccagtcgaaatggacttgagaaatacatcctgcaggcagcttcaaaagaaatcagagactgttggt
|
tttcagaaataagtaaattattgatggaacaacaaaataatatcaaagaccaaggaaatccacagtttgaaatgagc
|
acgagcaaaggcagtggagcaggatccggaccatggattaaaaatatggaaagagctaccactagcaaggaagaccc
|
ggcctccagcacaggagggattaaaggctgctccagcagggagtttagctccatggacacctttgaagactgtgaag
|
gcgcagaagacatggaaaaggagagcagtgctctgagtctcgcgggccttttccagtcggacgacagtcacgaaacc
|
tgttcctccaaatctgctttcctggagaggggagaaagcagccagggagaaaaagaagaacgcgatgaggaggaaac
|
ggcgacccgcagcaccgaggaggagcgcgctggggcgtccacgggccggctggctcctgcgggggcgacggctggtt
|
tccaggcgagggcgctgcgcccgaggacctccgcccaggagagctgacctccctgcggacgcccccgctcctcggct
|
ccagagcgcccgcattcccgggagaggcggtgtgggggcccgggccctgcccagctacgcagaaagcagccggagcc
|
tcggcggcggcagaaaggggacaaccagggcctcctccgaggagcccgaggggtgtcctgggtgcgcgcctagctcc
|
gcacgggggacctcggagctgctctaaggcgcctgcagaggcgagcagagcccgcagcccacgccttctcgaccgcg
|
cacttcgacattcggagccgggcaattctttgctgcgtgggcttctctgtgctcccacggtaggatgtttagtagca
|
cccctggcctctacccactaggtgccaggaatgcgccaccccatcctccaccccgcccccaaatcgtgacaatcaaa
|
aatgcctgcagacacgcccgcatttctccagggcggggtgggaatcggttgagagccgcttagcccgagccttggag
|
gagccggagccgctcaaacccggcgggggccgcagactgggagctcccggtccgcctcccagcatccctgcgagcgt
|
tcatggggtgttcgtgttagtgccaagattgcttcgttgtagagagagttcgttccaagttactttctgaggtattt
|
tatgtatcgatttattagtttttaaatgagttttgttagtttcagttgtattttatttttagttttattagttgatt
|
ttcatttctttgtagctttctggttatttaattttatagtttcagttactggtttatagttactttattttcaaagt
|
tatttagttgttcattttcagttatttatatgtagttgttttgttttaggagttacagatgttcaaattaatttgct
|
tggaatttatttatttatttatttatttatttttcgagacggagtctcgctctgtcgcccaggctggagtgcagtgg
|
tgtgatctcggctcactgcaaaccgcctcccgggctcacgccattctcctgcctcagcctcctgagtagctgggact
|
acaggcgcccgccaccacgcccggctaattttttatttggatttttagtagagacggggtttccccgtgttagccag
|
gatggtctcgatctcctgacctcgtgatccccctgcctcggcctcccaaagtgctgggattacaggcgtgagccacc
|
gcgcccagccggaatttatttttaattatctttacaattattatctgagttatttaccttcatagttatttcacttt
|
atcttattggagtttttgagttatttatttttacagtaacttatttgactattaaacactcactggaagttcatg
Following is a NUMA1 cDNA sequence (SEQ ID NO: 14).
|
|
NM_006185 [gi:5453819] Homo sapiens nuclear mitotic apparatus protein 1
(NUMA1), mRNA.
|
|
gcccacgaagaggtacgattccggagaatcgcgaggcagagcgggagcgcgcagccaggtggaaactaattctaagc
|
cagactgctggagatcaccctgttctagtgtgtggaggcttccaccaggagtctggagtgcaatggcacgatctcgg
|
ctcactgcaacctccacctcccaggttcaagcgattctcctgcctcagcctcccaagtagctgggattacaggcgca
|
ttggagtgactgtctggcatcaccaagatgacactccacgccacccggggggctgcactcctctcttgggtgaacag
|
tctacacgtggctgaccctgtggaggctgtgctgcagctccaggactgcagcatcttcatcaagatcattgacagaa
|
tccatggcactgaagagggacagcaaatcttgaagcagccggtgtcagagagactggactttgtgtgcagttttctg
|
cagaaaaatcgaaaacatccctcttccccagaatgcctggtatctgcacagaaggtgctagagggatcagagctgga
|
actggcgaagatgaccatgctgctcttataccactctaccatgagctccaaaagtcccagggactgggaacagtttg
|
aatataaaattcaggctgagttggctgtcattcttaaatttgtgctggaccatgaggacgggctaaaccttaatgag
|
gacctagagaacttcctacagaaagctcctgtgccttctacctgttctagcacattccctgaagagctctccccacc
|
tagccaccaggccaagagggagattcgcttcctagagctacagaaggttgcctcctcttccagtgggaacaactttc
|
tctcaggttctccagcttctcccatgggtgatatcctgcagaccccacagttccagatgagacggctgaagaagcag
|
cttgctgatgagagaagtaatagggatgagctggagctggagctagctgagaaccgcaagctcctcaccgagaagga
|
tgcacagatagccatgatgcagcagcgcattgaccgcctagccctgctgaatgagaagcaggcggccagcccactgg
|
agcccaaggagcttgaggagctgcgtgacaagaatgagagccttaccatgcggctgcatgaaaccctgaagcagtgc
|
caggacctgaagacagagaagagccagatggatcgcaaaatcaaccagctttcggaggagaatggagacctttcctt
|
taagctgcgggagtttgccagtcatctgcagcagctacaggatgccctcaatgagctgacggaggagcacagcaagg
|
ccactcaggagtggctagagaagcaggcccagctggagaaggagctcagcgcagccctgcaggacaagaaatgcctt
|
gaagagaagaacgaaatccttcagggaaaactttcacagctggaagaacacttgtcccagctgcaggataacccacc
|
ccaggagaagggcgaggtgctgggtgatgtcttgcagctggaaaccttgaagcaagaggcagccactcttgctgcaa
|
acaacacacagctccaagccagggtagagatgctggagactgagcgaggccagcaggaagccaagctgcttgctgag
|
cggggccacttcgaagaagaaaagcagcagctgtctagcctgatcactgacctgcagagctccatctccaacctcag
|
ccaggccaaggaagagctggagcaggcctcccaggctcatggggcccggttgactgcccaggtggcctctctgacct
|
ctgagctcaccacactcaatgccaccatccagcaacaggatcaagaactggctggcctgaagcagcaggccaaagag
|
aagcaggcccagctagcacagaccctccaacagcaagaacaggcctcccagggcctccgccaccaggtggagcagct
|
aagcagtagcctgaagcagaaggagcagcagttgaaggaggtagcggagaagcaggaggcaactaggcaggaccatg
|
cccagcaactggccactgctgcagaggagcgagaggcctccttaagggagcgggatgcggctctcaagcagctggag
|
gcactggagaaggagaaggctgccaagctggagattctgcagcagcaacttcaggtggctaatgaagcccgggacag
|
tgcccagacctcagtgacacaggcccagcgggagaaggcagagctgagccggaaggtggaggaactccaggcctgtg
|
ttgagacagcccgccaggaacagcatgaggcccaggcccaggttgcagagctagagttgcagctgcggtctgagcag
|
caaaaagcaactgagaaagaaagggtggcccaggagaaggaccagctccaggagcagctccaggccctcaaagagtc
|
cttgaaggtcaccaagggcagccttgaagaggagaagcgcagggctgcagatgccctggaagagcagcagcgttgta
|
tctctgagctgaaggcagagacccgaagcctggtggagcagcataagcgggaacgaaaggagctggaagaagagagg
|
gctgggcgcaaggggctggaggctcgattactgcagcttggggaggcccatcaggctgagactgaagtcctgcggcg
|
ggagctggcagaggccatggctgcccagcacacagctgagagtgagtgtgagcagctcgtcaaagaagtagctgcct
|
ggcgtgacgggtatgaggatagccagcaagaggaggcacagtatggcgccatgttccaggaacagctgatgactttg
|
aaggaggaatgtgagaaggcccgccaggagctgcaggaggcaaaggagaaggtggcaggcatagaatcccacagcga
|
gctccagataagccggcagcagaacaaactagctgagctccatgccaacctggccagagcactccagcaggtccaag
|
agaaggaagtcagggcccagaagcttgcagatgacctctccactctgcaggaaaagatggctgccaccagcaaagag
|
gtggcccgcttggagaccttggtgcgcaaggcaggtgagcagcaggaaacagcctcccgggagttagtcaaggagcc
|
tgcgagggcaggagacagacagcccgagtggctggaagagcaacagggacgccagttctgcagcacacaggcagcgc
|
tgcaggctatggagcgggaggcagagcagatgggcaatgagctggaacggctgcgggccgcgctgatggagagccag
|
gggcagcagcaggaggagcgtgggcagcaggaaagggaggtggcgcggctgacccaggagcggggccgtgcccaggc
|
tgaccttgccctggagaaggcggccagagcagagcttgagatgcggctgcagaacgccctcaacgagcagcgtgtgg
|
agttcgctaccctgcaagaggcactggctcatgccctgacggaaaaggaaggcaaggaccaggagttggccaagctt
|
cgtggtctggaggcagcccagataaaagagctggaggaacttcggcaaaccgtgaagcaactgaaggaacagctggc
|
taagaaagaaaaggagcacgcatctggctcaggagcccaatctgaggctgctggcaggacagagccaacaggcccca
|
agctggaagcactgcgggcagaggtgagcaagctggaacagcaatgccagaagcagcaggagcaggctgacagcctg
|
gaacgcagcctcgaggctgagcgggcctcccgggctgagcgggacagtgctctggagactctgcagggccagttaga
|
ggagaaggcccaggagctagggcacagtcagagtgccttagcctcggcccaacgggagttggctgccttccgcacca
|
aggtacaagaccacagcaaggctgaagatgagtggaaggcccaggtggcccggggccggcaagaggctgagaggaaa
|
aatagcctcatcagcagcttggaggaggaggtgtccatcctgaatcgccaggtcctggagaaggagggggagagcaa
|
ggagttgaagcggctggtgatggccgagtcagagaagagccagaagctggaggagagctgcgcctgctgcaggcaga
|
gacagccagcaacagtgccagagctgcagaacgcagctctgctctgcgggaggaggtgcagagcctccgggagggag
|
gctgagaaacagcgggtggcttcagagaacctgcggcaggagctgacctcacaggctgagcgtgcggaggagctggg
|
ccaagaattgaaggcgtggcaggagaagttcttccagaaagagcaggccctctccaccctgcagctcgagcacacca
|
gcacacaggccctggtgagtgagctgctgccagctaagcacctctgccagcagctgcaggccgagcaggccgctgcc
|
gagaaacgccaccgtgaggagctggagcagagcaagcaggccgctgggggactgcgggcagagctgctgcgggccca
|
gcgggagcttggggagctgattcctctgcggcagaaggtggcagagcaggagcgaacagctcagcagctgcgggcag
|
agaaggccagctatgcagagcagctgagcatgctgaagaaggcgcatggcctgctggcagaggagaaccgggggctg
|
ggtgagcgggccaaccttggccggcagtttctggaagtggagttggaccaggcccgggaaaagtatgtccaagagtt
|
ggcagccgtacgtgctgatgctgagacccgtctggctgaggtgcagcgagaagcacagagcactgcccgggagctgg
|
aggtgatgactgccaagtatgagggtgccaaggtcaaggtcctggaggagaggcagcggttccaggaagagaggcag
|
aaactcactgcccaggtggaagaactgagtaagaaactggctgactctgaccaagccagcaaggtgcagcagcagaa
|
gctgaaggctgtccaggctcagggaggcgagagccagcaggaggcccagcgcttccaggcccagctgaatgaactgc
|
aagcccagttgagccagaaggagcaggcagctgagcactataagctgcagatggagaaagccaaaacacattatgat
|
gccaagaagcagcagaaccaagagctgcaggagcagctgcggagcctggagcagctgcagaaggaaaacaaagagct
|
gcgagctgaagctgaacggctgggccatgagctacagcaggctgggctgaagaccaaggaggctgaacagacctgcc
|
gccaccttactgcccaggtgcgcagcctggaggcacaggttgcccatgcagaccagcagcttcgagacctgggcaaa
|
ttccaggtggcaactgatgctttaaagagccgtgagccccaggctaagccccagctggacttgagtattgacagcct
|
ggatctgagctgcgaggaggggaccccactcagtatcaccagcaagctgcctcgtacccagccagacggcaccagcg
|
tccctggagaaccagcctcacctatctcccagcgcctgccccccaaggtagaatccctggagagtctctacttcact
|
cccatccctgctcggagtcaggcccccctggagagcagcctggactccctgggagacgtcttcctggactcgggtcg
|
taagacccgctccgctcgtcggcgcaccacgcagatcatcaacatcaccatgaccaagaagctagatgtggaagagc
|
cagacagcgccaactcatcgttctacagcacgcggtctgctcctgcttcccaggctagcctgcgagccacctcctct
|
actcagtctctagctcgcctgggttctcccgattatggcaactcagccctgctcagcttgcctggctaccgccccac
|
cactcgcagttctgctcgtcgttcccaggccggggtgtccagtggggcccctccaggaaggaacagcttctacatgg
|
gcacttgccaggatgagcctgagcagctggatgactggaaccgcattgcagagctgcagcagcgcaatcgagtgtgc
|
cccccacatctgaagacctgctatcccctggagtccaggccttccctgagcctgggcaccatcacagatgaggagat
|
gaaaactggagacccccaagagaccctgcgccgagccagcatgcagccaatccagatagccgagggcactggcatca
|
ccacccggcagcagcgcaaacgggtctccctagagccccaccagggccctggaactcctgagtctaagaaggccacc
|
agctgtttcccacgccccatgactccccgagaccgacatgaagggcgcaaacagagcactactgaggcccagaagaa
|
agcagctccagcttctactaaacaggctgaccggcgccagtcgatggccttcagcatcctcaacacacccaagaagc
|
tagggaacagccttctgcggcggggagcctcaaagaaggccctgtccaaggcttcccccaacactcgcagtggaacc
|
cgccgttctccgcgcattgccaccaccacagccagtgccgccactgctgccgccattggtgccacccctcgagccaa
|
gggcaaggcaaagcactaaagggccagtaccagtgagtggccccacctgtgtccccgatgctgccgtcacctggtcc
|
tccgcctactgtccctctcagtgccttctctcagctcccaggccaacagtagccaaacccctagagacagtgatgcc
|
tgcccgcaccctggcctggcccctggtccttcactggcgccttctcggagctggcccagggggcctggagcatggac
|
agtgtgggcgctctccctaccttgcctccttttttcttaaagcaaagtcacttctccatcacaaccagatttgaggc
|
tggttttgatggctgggtccttgggcctggccagtcttcctcttagcctctggatctagaagggaccataagaggag
|
taggccctggttcctgctgtcctggtggctgggccagcaggggccctcactcttgaagtccaggactgggtctgacc
|
tggtgggagcacctgccagaggatgctctttcccaggacggatgggccctgtgtctcaggagtggggttgggggaca
|
gccttcagcagcagctcacaccctaccttccccagacttgcactggggtgggatttggagtgatgggaaggttttta
|
agggccggggatggatcttttctaaatgttattacttgtaaataaagtctattttt
|
Following is a GALE cDNA sequence (SEQ ID NO: 15).
|
|
NM_000403.2 [GI:9945333] Homo sapiens galactose-4-epimerase, UDP-(GALE),
mRNA.
|
|
gactctccagtcctcagtcaccttggacaaagaagtgtggatcctcagattccatcttttccaactccaaggtgcca
|
tggcagagaaggtgctggtaacaggtggggctggctacattggcagccacacggtgctggagctgctggaggctggc
|
tacttgcctgtggtcatcgataacttccataatgccttccgtggagggggctccctgcctgagagcctgcggcgggt
|
ccaggagctgacaggccgctctgtggagtttgaggagatggacattttggaccagggagccctacagcgtctcttca
|
aaaagtacagctttatggcggtcatccactttgcggggctcaaggccgtgggcgagtcggtgcagaagcctctggat
|
tattacagagttaacctgaccgggaccatccagcttctggagatcatgaaggcccacggggtgaagaacctggtgtt
|
cagcagctcagccactgtgtacgggaacccccagtacctgccccttgatgaggcccaccccacgggtggttgtacca
|
acccttacggcaagtccaagttcttcatcgaggaaatgatccgggacctgtgccaggcagacaagacttggaacgta
|
gtgctgctgcgctatttcaaccccacaggtgcccatgcctctggctgcattggtgaggatccccagggcatacccaa
|
caacctcatgccttatgtctcccaggtggcgatcgggcgacgggaggccctgaatgtctttggcaatgactatgaca
|
cagaggatggcacaggtgtccgggattacatccatgtcgtggatctggccaagggccacattgcagccttaaggaag
|
ctgaaagaacagtgtggctgccggatctacaacctgggcacgggcacaggctattcagtgctgcagatggtccaggc
|
tatggagaaggcctctgggaagaagatcccgtacaaggtggtggcacggcgggaaggtgatgtggcagcctgttacg
|
ccaaccccagcctggcccaagaggagctggggtggacagcagccttagggctggacaggatgtgtgaggatctctgg
|
cgctggcagaagcagaatccttcaggctttggcacgcaagcctgaggaccctcccctaccaaggaccaggaaaagca
|
gcagctgcctgctctccagcctctggaggaactcagggccctggagctgctggggccaagccaagggcctcccctac
|
ctcaaaccccagctgggcccgcttagcccaccaggcatgaggccaaggctccactgaccaggaggccgaggtctcta
|
actcttatcttccacagggtccaagagttcatcaggacccccaagagtgagtgagggggcaaggctctggcacaaaa
|
cctcctcctcccaggcactcatttatattgctctgaaagagctttccaaagtatttaaaaataaaaacaagttttct
|
tacactgg
|
Following is a DPF3 cDNA sequence (SEQ ID NO: 16).
|
|
NM_012074 [gi:13442997] Homo sapiens D4, zinc and double PHD fingers,
family 3 (DPF3), mRNA.
|
|
acattgtagcaaaatggcgactgtcattcacaaccccctgaaagcgctcggggaccagttctacaaggaagccattg
|
agcactgccggagttacaactcacggctgagtgcagagcgcagcgtgcgtcttcccttcctggactcacagactggg
|
gtggcccagaacaactgctacatctggatggagaagaggcaccgaggcccaggccttgccccgggccagctgtatac
|
ataccctgcccgctgctggcgcaagaagagacgattgcacccacctgaagatccaaaactgcggctgctggagataa
|
aacctgaagtggagcttcccctgaagaaggatgggttcacctcagagagcaccacgctggaagccttgctccgtggc
|
gagggggttgagaagaaggtggatgccagggaggaggaaagcatccaggaaatacagagggttttggaaaatgatga
|
aaatgtagaagaagggaatgaagaagaggatttggaagaggatattcccaagcgaaaggacaggactagaggacggg
|
ctcgctgccctctcccttccctgcactgtttttcctcccttccctctgccgtgatagatgctaaggagtggggtgga
|
ggtgggaagtgggaagcaacagtggcgtataggaaaaagaaaatataccccgtgcacattttcaacatgtagttgaa
|
gaagcctaaattaggtactagaaaaaaaaaaaggacagaaacactgcctgatatgtgagcaagagcatgaaaatata
|
gaatgattatctcagagcagaggaggtggggagcaggtggctggagagaggcggggtaggtaggcagggcgtccctg
|
gctcaccaatgcgtctggtccacatggcatttgggaaagcagatgggtcatgcttttgcaatgaatggtcagatgct
|
tagggggcatttgtgctcctctggccaggaaagggaacagagtccatccaagctgccccccactcatctgccatggt
|
tgtccaccctgggggtttttcctctgaaggaaaatgaacccatcttttgcctgccatgaatcattgcagggcaggct
|
gttactggctaaattaaaacccttggcagggcatcgactgtgtgcgaggcaatgctctaggtcctgtaggggctgga
|
aaataaaccgcatgctggcctagccttcaagttgcttttcagccatgaaactaagctctgccaagcaatcgtgattg
|
taggtcaagtatcgcgccatcacggaaggtgtaagtatatgtaggtttctctgttgaggatgcgtgttcctcagtag
|
aagacaagcaggtggaggcatccagtgatttctaccctgtggaggctgaggggtcgggggaagaaaacagatgacct
|
cagcctagttgctttaatctgcttttccaagcactggatgcccttggatgacagcatcctcagcattaaaactggtg
|
aactgatgaagtcacctggcctggagtgtgttgggcagccagtgtccccagagctgcttgtgggtttctggggtgga
|
aggcagggaggtgcaactggcagggcctgatcagaggcagaaaatgacccccacagtggtcttttccctgctagaga
|
aagcagagagcgggactgggggggtgggggcttcaagtacagattgggcacactccaccagaccccagcaaggtcag
|
ctgccccacgcctgtatctggcactgctggtgtgtgcagggatgaaacccagcatcagagaggttttcagcaaacct
|
tccatgctcacctttggccaggtgcttgtcagatcctagcttcgtgctggcttagactctcagttgtttgtgttgac
|
agcattaggaataaaccgtttgtttcatctttccttttctccacacgtgtcacagccagatttcagctttgagttat
|
tccctgaagaagccacaccaaccttgctttcaagcaaaatgcctgggcttgggggaaggtgtgtatctgtccatgtg
|
tggatgtcggctcagagctatagcttctctgtggggggtggcccaagggaaggctcctctggggccctggatggcac
|
atgactcccagtgaggagaattcaggtgatctctgtggaggtagtcagggacacaaggcttggctgtgagtctggtt
|
ttaaagtgcgtgacagcctgaaaagcatgcaggggtttggtccactcacctacttgaaagcctgtgggcaacgttct
|
tttgagccaagacttctctgaatggccctgctggtggaaggggtgaggcaaaggcctctgacttggaccctttccac
|
accagactggcagcacttcccccaggcagccagtggtgggccctgagccctcaggtccccagctccttgagggatga
|
acctgggagcccaagagccagtggctgagctctgagaaggctccatctcccacctgcccttgagcgcgctctcaggc
|
tgagaacacggtctcatcaggcgccttcctggcctgatgctgtgctgtctacgtcacacggtcgattcacaaaagcc
|
agaactagacctcaaccaggtcatctccccgttgccaagtgggttcagggtgagggcaatttgtaagctcaatttct
|
ctgacagccaagacatggagcatctctgctaagaagccaaaagaaattggttttcttcttctcattgctgaagcccc
|
tctgtgtctcttctcagggacaggctggtccagtggctttggtgagggcgcctccatttgtgaacgctgggattcct
|
ctgggtgggctttggcaggtggctcctatggtaggaaggatgaccaggtccctgggaatgagctgcctacctgctgc
|
tccacgaggaagctcaggcctgcacaggctccaccaggccttggatgccctctagttgagtcagagaccctggaaac
|
acactgagatctccaattgctgcctccattgatgtctctagacctgcagatacgaagcaaacctgggattgcttctt
|
ccaggtatgggcaccagagagggaggccactgcaacattttatccccatcattccaaaatgcttgcttgtctctttt
|
acctcacactcacaactccttctgagactctcagtcataaaggaatgaccaagagagtgggtctccagtgagagaaa
|
tgcctatgaaagagggtttccctttttgctcttttgaacaccctccccactgatccttgggacccaacgccgcattg
|
cctcttgcagatgaggttttgccttgggctgcttgggtacttcagaccaggactgagtctgacacagctttcatgag
|
gttacagaaaagggctacagatttgggaagctgtgtgtaatggtcttgagacaatatctccatttggcccaccctgg
|
cttctctaaaaagcaacgacagcaacagacaaacaaaaagctcccacctcccaccccgttagctgtcctcctccttc
|
actgtgatgtggttgcggtctctgtaggtgtgtgtgccacccttgtcctctgtcctctggggatgtgcccttcccac
|
gtgtgtcaggttcccactctttcgtggttcctaacgtgaagtgctgtgatgtttctgccctgcctaaggaacgtatc
|
aagctctctcagtgtttcagtgttggagattgaggctgtgccacatcttctgccatcctaaggggacatgatggttc
|
tgtgattcccagagagctggcagattgtgacaatctccaggagaacctacagattggaagcagcccacacctgatgt
|
ggactcctgtcccgggactcactcttcattcagaagactggtggcccacgtgccaggaccaccccacctctcttgct
|
gccttttctcctgtcctgatggggttctgggagggagacctgtcgctgatgagatgaagaatgtggggatcgagcag
|
ccttcttctttgggacccctcgatatcccatggaatgctcgcacgttctcaaagactgagtcacaagcccctacccc
|
ttccttgctgtggttagtatcttgttctgtgattggttagcaatgttgactacccacgtagtgaatcttttgtctgc
|
aatttagagaatgtgtaaacaaataaaaggctttaaaactc
|
Following is a LOC145197 cDNA sequence (SEQ ID NO: 17).
|
|
XM_096734.1 GI:18582778: Homo sapiens hypothetical LOC145197 (LOC145197),
mRNA.
|
|
agtgcaatgagcttcatgctgaatactgatttgaagtgtggttcaccacacagacttaaattgtccttcccacaact
|
ttatctgagaagcatgacaacggtgacaatcacaggactagttttattggtcaggatgtggtgttactatattaaag
|
cgcttcaagttttcatagcgctcgtcaaacagagacctcggaacgctctgcagacattaattaatgttcgctccggc
|
cctggaagccatttcaccaatggaaattccgatgagaaaggaagaaacgaggggttcaaggccgcgccgttgtgagt
|
ccgctgcggaactaggaactgaaaccccgtggttcccaatgagccagcgaaagtctgtcgaagtattgagcacccct
|
attgaagactgtgggagttttggcggcttaatgggattgtgttcggtccttcaggctctcctttaaaagattccatg
|
gcaccaacgagactccaataaaagggcctctctaa
|
Following are ICAM, MAPK10, KIAA0861, NUMA1, GALE, DPF3 and LOC145197 amino acid sequences (SEQ ID NO: 18, 19, 20, 21, 22, 23, 24, 25, 26 and 27, respectively). Following is an ICAM1 cDNA sequence (SEQ ID NO: 18).
|
NP_000192 [gi: 4557878]
intercellular adhesion molecule 1 precursor;
CD54 [Homo sapiens]
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCST
|
SCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQ
|
STAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVL
|
LRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELF
|
ENTSAPYQLQTEVLPATPPQLVSPRVLEVDTQGTVVCSLDGLEPVSEAQV
|
HLALGDQRLNPTVTYGNDSPSAKASVSVTAEDEGTQRLTCAVILGNQSQE
|
TLQTVTIYSFPAPNVTLTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPL
|
GPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDE
|
RDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRD
|
LEGTYLCRARSTQGEVTREVTVNVLSPRYEIVIITVVAAAVIMGTAGLST
|
YLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
Following is an ICAM4 amino acid sequence (SEQ ID NO: 19).
|
NP_001535 [gi:4504561] intercellular adhesion,
molecule 4 isoform 1 precursor; Landsteiner-
Wiener blood group protein [Homo sapiens].
MGSLFPLSLLEFLAAAYPGVGSALGRRTKRAQSPKGSPLAPSGTSVPFWV
|
RMSPEFVAVQPGKSVQLNCSNSCPQPQNSSLRTPLRQGKTLRGPGWVSYQ
|
LLDVRAWSSLAHGLVTCAGKTRWATSRITAYKPPHSVILEPPVLKGRKYT
|
LRCHVTQVFPVGYLVVTLRHGSRVIYSESLERFTGLDLANVTLTYEFAAG
|
PRDFWQPVICHARLNLDGLVVRNSSAPITLMLAWSPAPTALASGSIAALV
|
GTLLTVGAAYLCKCLAMKSQA
Following is an ICAM5 amino acid sequence (SEQ ID NO: 20).
|
NP_003250 [gi:12545404] intercellular adhesion
molecule 5 precursor; telencephalin [Homo sapiens]
MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGS
|
LWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCF
|
FRCARRTLQARGLTRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPR
|
ASLTLTLLRGAQELIRRSFAGEPPPARGAVLTATVLARREDHGANFSCRA
|
ELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPVSCT
|
LDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQL
|
ICNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGTQA
|
LVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSA
|
ELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGA
|
VLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPE
|
RITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLLRVAREHAGTY
|
RCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDG
|
KPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRTPRVLAPGIYVCNATNR
|
HGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGV
|
RCSREGIPWPEQQRVSREDAGTYHCVATNAHGTDSRTVTVGVHYRPVVAE
|
LAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLS
|
VAGAMGSHGGEYECARTNAHGRHARRITVRVAGPWLWVAVGGAAGGAALL
|
AAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGGAGGAAGAEGG
|
PEAAGGAAESPAEGEVFAIQLTSA
Following is a MAPK10 amino acid sequence (SEQ ID NO: 21).
|
NP_002744 [gi:4506081] mitogen-activated protein
kinase 10 isoform 1; JNK3 alpha protein kinase;
stress activated protein kinase beta; MAP kinase;
c-Jun kinase 3; c-Jun N-terminal kinase 3; stress
activated protein kinase JNK3 [Homo sapiens]
MSLHPLYYCSEPTLDVKIAFCQGPDKQVDVSYTAKHYNMSKSKVDNQFYS
|
VEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPPQ
|
NQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD
|
ANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD
|
CTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVG
|
CIMGEMVRHKILFPGRDYTDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
|
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISV
|
DDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMN
|
SEEKTKNGVVKGQPSPSAQVQQ
|
Additional isoforms are isoform 2 (NP_620448);
isoform 3 (NP_620446); isoform 4 (NP_620447)
Following is a first KIAA0861 amino acid sequence (SEQ ID NO: 22).
KIAA0861 Polypeptide Sequence Corresponding to SEQ ID NO: 3.
|
MTYLTSIPSVEAASIGEIVVIDRRRDKWSSVKASLTRTAVAFPGNLQLIF
|
ILRPSRFIQRTFTDIGIKYYRNEFKTKVPTIMVNSVSDLHGYIDKSQLTR
|
ELGGTLEYRHGQWVNHRTATENFALTLKTTAQMLQTFGSCLATAELPRSM
|
LSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLN
|
QLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQRFEHDFCKAK
|
LALDNLLEEQAEFTGTGDSVMHVEQILKEHKKLEEKSQESLEKAQLLALV
|
GDQLTQSHHYAADATRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQL
|
DKVSQWCEAGIYLLASQAVDKCQSREGVDTALNDIATFLGTVKEYPLLSP
|
KEFYNEFELLLTLDAKAKAQKVLQRLDDVQETFHKRQVSLMKLAAKQTRP
|
VQPVAPHPESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKE
|
DDETKFEVKSEEIFESHHERGNPELEQQARLGDLSPRRRIIRDLLETEEI
|
YIKEIKSIIDGYITPMDFTWLKHLIPDVLQNNKDFLFGNIRELYEFHNRT
|
FLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCA
|
YFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPG
|
ELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPD
|
DIGKLGKLLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCK
|
IRMEPGDQGLSPHYSFKKADKLMTLSIRQLGRGSHRKFEIASRNGLEKYI
|
LQAASKEIRDCWFSEISKLLMEQQNNIKDQGNPQFEMSTSKGSGAGSGPW
|
IKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFEDCEGAEDMEKESSA
|
LSLAGLFQSDDSHETCSSKSAFLERGESSQGEKEERDEEETATRSTEEER
|
AGASTGRLAPAGATAGFQARALRPRTSAQES (1031 aa)
Following is a second KIAA0861 amino acid sequence (SEQ ID NO: 23).
|
NP_055893: KIAA0861
MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFA
|
ILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGF
|
IVVIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGI
|
KYYRNEFKTKVPIIMVNSVSDLHGYTDKSQLTRELGGTLEYRHGQWVNHR
|
TATENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDKL
|
QDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDE
|
TEKAFSHFWSEHHLKLNQCLQLQHPEHDFCKAKLALDNLLEEQAEFTGTG
|
DSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRP
|
RCVELRHLCDDFTNGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQ
|
AVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKA
|
KAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSS
|
KTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESH
|
HERGNPELEQQARLGDLSPRRRITRDLLETEEIYIKEIKSIIDGYITPMD
|
FIWLKHLIPDVLQNNKDFLFGNTRELYEFHNRTFLKELEKCAENPELLAH
|
CFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQRQLDHNLPLFK
|
YLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKDSA
|
FSTWLQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVW
|
TIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK
|
KTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSETS
|
KLLMEQQNNIKDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASS
|
TGGIKGCSSREFSSMDTFEDCEGAEDMEKESSALSLAGLFQSDDSHETCS
|
SKSAFLERGESSQGEKEERDEEETATRSTEEERAGASTGRLAPAGATAGF
|
QARALRPRTSAQES (1114 aa)
Following is a NUMA1 amino acid sequence (SEQ ID NO: 24). NP13006176 [gi: 5453820] nuclear mitotic appratus protien 1 [Homo Sapiens]
|
MTLHATRGAALLSWVNSLHVADPVEAVLQLQDCSTFIKIIDRIHGTEEGQ
|
QILKQPVSERLDFVCSFLQKNRKHPSSPECLVSAQKVLEGSELELAKMTM
|
LLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLDHEDGLNLNEDLENF
|
LQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGS
|
PASPMGDTLQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQ
|
IAMMQQRTDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQ
|
DLKTEKSQMDRKTNQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSK
|
ATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDN
|
PPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKL
|
LAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQV
|
ASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLR
|
HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERD
|
AALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSR
|
KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQL
|
QEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH
|
KRERKELEEERAGRKGLEARLLQLGEAHQAETEVLRRELAEAMAAQHTAE
|
SECEQLVKEVAAWRDGYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQ
|
EAKEKVAGIESHSELQISRQQNKLAELHANLARALQQVQEKEVRAQKLAD
|
DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPE
|
WLEEQQGRQFCSTQAALQANEREAEQMGNELERLRAALMESQGQQQEERG
|
QQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQE
|
ALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE
|
HASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSL
|
EAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQ
|
DHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKE
|
LKRLVMAESEKSQKLEESCACCRQRQPATVPELQNAALLCGRRCPASGRE
|
AEKQRVASEMLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH
|
TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL
|
PAQRELGELIPLRQKVAEQERTAQQLPAEKASYAEQLSMLKKAHGLLAEE
|
NRGLGERANLGRQFLEVELDQAREKYVQELAAVPADAETRLAEVQREAQS
|
TARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEELSKKLADSDQA
|
SKVQQQKLKAVQAQGGESQQEAQRFQAQLNELQAQLSQKEQAAEHYKLQM
|
EKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGL
|
KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSREPQA
|
KPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSVPGEPASPISQRLP
|
PKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRTTQI
|
INITMTKKIDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARLGSPD
|
YGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQL
|
DDWNRIAELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQET
|
LRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPM
|
TPRDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLL
|
RRGASKKALSKASPNTRSGTRRSPRIATTTASAATAAAIGATPRAKGKAK
|
H
Following is a GALE amino acid sequence (SEQ ID NO: 25).
|
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLR
|
RVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQK
|
PLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPT
|
GGCTNPYGKSKFFIEEMIRDLCQADKTWNVVLLRYFNPTGAHASGCIGED
|
PQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKG
|
HIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARR
|
EGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
Following is a DPF3 amino acid sequence (SEQ ID NO: 26).
|
NP_036206 [gi:13442998] cer-d4 (mouse) homolog;
2810403B03Rik [Homo sapiens].
MATVIHNPLKALGDQFYKEAIEHCRSYNSRLSAERSVRLPFLDSQTGVAQ
|
NNCYEWMEKRHRGPGLAPGQLYTYPARCWRKKRRLHPPEDPKLRLLEIKP
|
EVELPLKKDGFTSESTTLEALLRGEGVEKKVDAREEESIQEIQRVLENDE
|
NVEEGNEEEDLEEDIPKRKDRTRGRARCPLPSLHCFSSLPSAVIDAKEWG
|
GGGKWEATVAYRKKKIYPVHIFNM
Following is a LOC145197 amino acid sequence (SEQ ID NO: 27).
|
XP_096734.1 GI:18582779: hypothetical protein
XP_096734 [Homo sapiens]
MSFMLNTDLKCGSPHRLKLSFPQLYLRSMTTVTITGLVLLVRMWCYYIKA
|
LQVFIAIJVKQRPRNALQTLINVRSGPGSHFTNGNSDEKGRNEGFKAAPL
Modifications may be made to the foregoing without departing from the basic aspects of the invention. Although the invention has been described in substantial detail with reference to one or more specific embodiments, those of skill in the art will recognize that changes may be made to the embodiments specifically disclosed in this application, yet these modifications and improvements are within the scope and spirit of the invention, as set forth in the claims which follow. For example, polymorphic variants disclosed in an international patent application filed concurrently herewith, having attorney docket no. 524592007041, are applicable to embodiments described herein. Citation of the above publications or documents is not intended as an admission that any of the foregoing is pertinent prior art, nor does it constitute any admission as to the contents or date of these publications or documents. Each patent, patent application, document and publication referenced herein is hereby incorporated by reference in its entirety.
Patent Application
20050272043
