Methods for identifying risk of melanoma and treatments thereof

Abstract

Provided herein are methods for identifying risk of melanoma in a subject and/or subjects at risk of melanoma, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating melanoma, therapeutic methods for treating melanoma in a subject and compositions comprising one or more melanoma cells and one or more NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 directed agents. These embodiments are based upon an analysis of polymorphic variations in a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid, exemplified by nucleotide sequences of SEQ ID NO: 1-17.

Description

FIELD OF THE INVENTION

The invention relates to genetic methods for identifying risk of melanoma and treatments that specifically target the disease.

BACKGROUND

In some parts of the world, especially among western countries, the number of people who develop melanoma is increasing faster than any other cancer. In the United States, for example, the number of new cases of melanoma has more than doubled in the past twenty years. The probability of developing melanoma increases with age, but this disease effects people of all age groups. Melanoma is one of the most common cancers in young adults.

Melanoma occurs when melanocytes (pigment cells) become malignant. Most pigment cells are in skin, and when melanoma begins its etiology in the skin it is referred to as coetaneous melanoma. Melanoma may also occur in the eye and is called ocular melanoma or intraocular melanoma. Rarely, melanoma arises in the meninges, the digestive tract, lymph nodes or other areas where melanocytes are found. Within the skin, melanocytes are located throughout the lower part of the epidermis, the latter being the surface layer of the skin. Melanocytes produce melanin, which is the pigment that gives skin its natural color. When skin is exposed to the sun, melanocytes produce more pigment, causing the skin to tan or darken.

Sometimes, clusters of melanocytes and surrounding tissue form benign growths referred to as moles or nevi (singular form is nevus). Cells in or near the nevi can divide without control or order and form malignant tumors. When melanoma spreads, cancer cells often are found in the lymph nodes. If the cancer has reached the lymph nodes, it may mean that cancer cells have spread to other parts of the body such as the liver, lungs or brain, giving rise to metastatic melanoma.

Melanoma is currently diagnosed by assessing risk factors and by performing biopsies. Risk factors for melanoma are a family history of melanoma, the presence of dysplastic nevi, patient history of melanoma, weakened immune system, many ordinary nevi, exposure levels to ultraviolet radiation, exposure to severe sunburns especially as a child or teenager, and fair skin. In a biopsy, a pathologist typically examines the biopsied tissue under a microscope to identify cancer cells. Depending upon the thickness of a tumor, if one exists, a physician may order chest x-ray, blood tests, liver scans, bone scans, and brain scans to determine whether the cancer spread to other tissues. Also, a test that identifies p16 nucleotide sequences is sold.

Upon a diagnosis of melanoma, the standard treatment is surgery. Side effects of surgery typically are pain and scarring. Surgery is generally not effective, however, in controlling melanoma that is known to have spread to other parts of the body. In such cases, physicians may utilize other methods of treatment, such as chemotherapy, biological therapy, radiation therapy, or a combination of these methods. Chemotherapy agents for treating melanoma include cisplatin, vinblastine, and dacarbazine. Chemotherapy can lead to side effects such as an increased probability of infection, bruising and bleeding, weakness and fatigue, hair loss, poor appetite, nausea and vomiting, and mouth and lip sores. Side effects of radiation therapy include fatigue and hair loss in the treated area. Biological therapies currently utilized for treatment of melanoma include interferon and interleuken-2. Side effects caused by biological therapies include flu-like symptoms, such as chills, fever, muscle aches, weakness, loss of appetite, nausea, vomiting, and diarrhea; bleeding and bruising skin; rashes, and swelling.

Certain melanoma therapeutics are in clinical trials. For example, canvaxin, which is a whole cell allogenic vaccine developed by irradiating tumor cells from two different patients, is under study. In addition, MAGE-1 and 3 minigenes and peptides and gp 100 peptides are being tested. Upcoming studies include testing of agents such as dacarbazine with a bcl-2 antisense oligonucleotide, and paclitaxel in combination with a matrix metalloprotease inhibitor.

SUMMARY

It has been discovered that polymorphic variations in NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO and/or REPS2 loci in human genomic DNA are associated with occurrence of melanoma. Thus, featured herein are methods for identifying a subject at risk of melanoma and/or determining risk of melanoma in a subject, which comprise detecting the presence or absence of one or more polymorphic variations associated with melanoma in a nucleic acid sample from the subject. The one or more polymorphic variations often are detected in or near a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence, which are set forth as SEQ ID NO: 1-17 respectively, or a substantially identical nucleotide sequence thereof.

Also featured are nucleic acids that encode a NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, and include one or more polymorphic variations associated with melanoma, and oligonucleotides which hybridize to those nucleic acids. Also provided are polypeptides encoded by nucleic acids having a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence, which include the full-length polypeptide, isoforms and fragments thereof. In an embodiment, an NID2 protein is encoded which includes a serine at amino acid position 656. In addition, featured are methods for genotyping a nucleic acid from an individual at positions described herein, methods for identifying candidate therapeutic molecules for treating melanoma and related disorders, as well as methods of treating melanoma in a subject by administering a therapeutic molecule.

Also provided are compositions comprising a melanoma cell and/or a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid, or a fragment or substantially identical nucleic acid thereof, with a RNAi, siRNA, a complementary or antisense DNA or RNA, or ribozyme nucleic acid designed from a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence. In an embodiment, the nucleic acid is designed from a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence that includes one or more melanoma associated polymorphic variations, and in some instances, specifically interacts with such a nucleotide sequence. Further, provided are arrays of nucleic acids bound to a solid surface, in which one or more nucleic acid molecules of the array are NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acids, or a fragment or substantially identical nucleic acid thereof, or a complementary nucleic acid of the foregoing. Featured also are compositions comprising a melanoma cell and/or a protein, polypeptide or peptide encoded by a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid with an antibody that specifically binds to the protein, polypeptide or peptide. In an embodiment, the antibody specifically binds to an epitope in a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 protein, polypeptide or peptide that includes a non-synonymous amino acid modification associated with melanoma, such as a serine at position 656 of a NID2 protein, polypeptide or peptide.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1A, 1B and 1C show proximal SNPs in and around a NRP1 region for males and females combined, females alone, and males alone, respectively. FIGS. 2A, 2B and 2C show proximal SNPs in and around a ENDO180 region for males and females combined, females alone, and males alone, respectively. FIGS. 3A, 3B and 3C show proximal SNPs in and around a CDK10 region for males and females combined, females alone, and males alone, respectively. FIGS. 4A, 4B and 4C show proximal SNPs in and around a PCLO region for males and females combined, females alone, and males alone, respectively. FIGS. 5A, 5B and 5C show proximal SNPs in and around a FPGT/CARK region for males and females combined, females alone, and males alone, respectively. FIGS. 6A, 6B and 6C show proximal SNPs in and around a REPS2 region for males and females combined, females alone, and males alone, respectively. The position of each SNP on the chromosome is shown on the x-axis and the y-axis provides the negative logarithm of the p-value comparing the estimated allele to that of the control group. Also shown are exons and introns of the genes in the approximate chromosomal positions.

FIG. 7A depicts effects of NRP1-directed siRNA on melanoma M14 cell line proliferation according to a WST 1 assay. FIG. 7B shows effects of NRP1-directed siRNA on melanoma A375 cell line proliferation according to a WST 1 assay.

FIG. 8 depicts effects of CDK10_siRNA on melanoma A375 cell line proliferation according to a WST-1 assay.

DETAILED DESCRIPTION

It has been discovered that polymorphic variants in and around NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequences are associated with occurrence of melanoma in subjects. Thus, detecting genetic determinants associated with an increased risk of melanoma occurrence can lead to early identification of melanoma or susceptibility to melanoma and early prescription of preventative measures and treatments. Also, associating NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polymorphic variants with melanoma has provided new targets for screening molecules useful in melanoma prognostics/diagnostics and melanoma treatments.

Melanoma and Sample Selection

Melanoma is typically described as a malignant neoplasm derived from cells capable of forming melanin. Melanomas arise most commonly in the skin of any part of the body, or in the eye, and rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. Melanoma occurs mostly in adults and may originate de novo or from a pigmented nevus or lentigo maligna. Melanomas frequently metastasize widely to regions such as lymph-nodes, skin, liver, lungs, and brain.

In the early phases, the cutaneous form is characterized by proliferation of cells at the dermal-epidermal junction that soon invade adjacent tissues. The cells vary in amount and pigmentation of cytoplasm; the nuclei are relatively large and irregular in shape, with prominent acidophilic nucleoli; and mitotic figures tend to be numerous. Other criteria for melanomas are asymmetry, irregular borders, heterogeneous color, large diameter, and a recent change in shape, size or pigmentation. Excised melanoma skin samples are often subjected to the following analyses: diagnosis of the melanocytic nature of the lesion and confirmation of its malignancy; maximum tumor thickness in millimeters (according to Breslow's method); assessment of completeness of excision of invasive and in situ components and microscopic measurements of the shortest extent of clearance; level of invasion (Clark); presence and extent of regression; presence and extent of ulceration; histological type and special variants; pre-existing lesion; mitotic rate; vascular invasion; neurotropism; cell type; tumor lymphocyte infiltration; and growth phase, vertical or radial.

Based in part upon selection criteria set forth above, individuals having melanoma can be selected for genetic studies. Also, individuals having no history of cancer or melanoma often are selected for genetic studies. Other selection criteria can include: a tissue or fluid sample is derived from an individual characterized as Caucasian; a sample is derived from an individual of German paternal and maternal descent; and relevant phenotype information is available for the individual. Phenotype information corresponding to each individual can include sex of the individual, number of nevi (e.g., actual number or relative number (e.g., few, moderate, numerous)), hair color (e.g., black, brown, blond, red), diagnosis of melanoma (e.g., tumor thickness, date of primary diagnosis, age of individual as of primary diagnosis, post-operative tumor classification, presence of nodes, occurrence of metastases, subtype, location), country or origin of mother and father, presence of certain conditions for each individual (e.g., coronary heart disease, cardiomyopathy, arteriosclerosis, abnormal blood clotting/thrombosis, emphysema, asthma, diabetes type 1, diabetes type 2, Alzheimer's disease, epilepsy, schizophrenia, manic depression/bipolar disorder, autoimmune disease, thyroid disorder, and hypertension), presence of cancer in the donor individual or blood relative (e.g., melanoma, basaliom/spinaliom/lentigo malignant/mycosis fungoides, breast cancer, colon cancer, rectum cancer, lung cancer, lung cancer, bronchus cancer, prostate cancer, stomach cancer, leukemia, lymphoma, or other cancer in donor, donor parent, donor aunt or uncle, donor offspring or donor grandparent).

Provided herein is a set of blood samples and a set of corresponding nucleic acid samples isolated from the blood samples, where the blood samples are donated from individuals diagnosed with melanoma. The sample set often includes blood samples or nucleic acid samples from 100 or more, 150 or more, or 200 or more individuals having melanoma, and sometimes from 250 or more, 300 or more, 400 or more, or 500 or more individuals. The individuals can have parents from any place of origin, and in an embodiment, the set of samples are extracted from individuals of German paternal and German maternal ancestry. The samples in each set may be selected based upon five or more criteria and/or phenotypes set forth above.

Polymorphic Variants Associated with Melanoma

A genetic analysis described hereafter linked melanoma with polymorphic variants of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 from human subjects. Genomic nucleotide sequences representative of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acids are set forth in SEQ ID NOS: 1-7, respectively, and are incorporated herein by reference from published database entries (see Examples section and http address at www.ncbi.nlm.nih.gov/LocusLink/). The following is a description of molecules encoded by such regions.

NRP1

NRP1 is known as neuropilin 1, NRP, VEGF165R (Vascular Endothelial Growth Factor-165 Receptor). NRP1 protein is 923 amino acids in length and the corresponding genomic nucleotide sequence has been mapped to chromosomal position 10p 12.

Neuropilin is a type I transmembrane protein and is an epitope recognized by a monoclonal antibody that labels specific subsets of axons in the developing Xenopus nervous system. Neuropilin comprises in its extracellular domain several distinctive motifs; its cytoplasmic domain is short (40 amino acids) and is highly conserved among Xenopus, mouse, and chick. An aberrant retinal pathway and visual centers in Xenopus tadpoles share a common cell surface molecule, A5 antigen (Dev. Biol. 135: 231-240, 1989). The gene encoding human neuropilin was cloned and the structure of the protein product was characterized (He & Tessier-Lavigne, Neuropilin is a receptor for the axonal chemorepellent semaphorin III. Cell 90: 739-751, 1997).

A VEGF receptor (NCBI MIM 192240) was discovered which reportedly binds VEGF165 but not VEGF121. This isoform-specific VEGF receptor (VEGF165R) is identical to human neuropilin-1, which is also a receptor for the collapsin/semaphorin family that mediates neuronal cell guidance (Soker et al., Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92: 735-745, 1998). It also was shown that when coexpressed in cells with KDR (VEGFR2; NCBI MIM 191306), neuropilin-1 enhances the binding of VEGF165 to KDR and VEGF165-mediated chemotaxis. Conversely, inhibition of VEGF165 binding to neuropilin-1 inhibits its binding to KDR and its mitogenic activity for endothelial cells. It was proposed that neuropilin-1 is a novel VEGF receptor that modulates VEGF binding to KDR and subsequent bioactivity and therefore may regulate VEGF-induced angiogenesis.

It was concluded that NRP1-mediated interactions are a necessary element in the initiation of the primary immune response and offer another example, like that of agrin (NCBI MIM 103320), of a molecule shared by neurologic and immunologic synapses (Tordjman et al., A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response. Nature Immun. 3: 477-482, 2002). It was shown that VEGF selectively upregulates NRP1 but not NRP2 via the VEGF receptor 2-dependent pathway. In a murine model of VEGF-dependent angioproliferative retinopathy, intense NRP1 mRNA expression was observed in the newly formed vessels. Furthermore, selective NRP1 inhibition in this model suppressed neovascular formation substantially. These results suggested that VEGF can not only activate endothelial cells directly but also contribute to robust angiogenesis in vivo by a mechanism that involves upregulation of its cognate receptor expression (Oh et al., Selective induction of neuropilin-1 by vascular endothelial growth factor (VEGF): a mechanism contributing to VEGF-induced angiogenesis. Proc. Nat. Acad. Sci. 99: 383-388, 2002).

Transgenic mice died in utero at embryonic day 8.5 when both NRP1 and NRP2, which they called Np1 and Np2, respectively, were knocked out. The yolk sacs of these mice were avascular. Mice deficient for NRP2 but heterozygous for NRP1 or deficient for NRP1 but heterozygous for NRP2 were also embryonic lethal and survived to embryonic days 10 to 10.5. Other details of the abnormal vascular phenotype resembled those of VEGF and Vefgr2 knockouts. The results suggested that neuropilins are early genes in embryonic vessel development and that both NRP1 and NRP2 are required (Takashima et al., Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc. Nat. Acad. Sci. 99: 3657-3662, 2002).

It was shown in zebrafish the NRP1 protein was a functional receptor for human VEGF165. Whole-mount in situ hybridization showed that transcripts of the zebrafish NRP1 gene during embryonic and early larval development were detected mainly in neuronal and vascular tissues. A knockdown of the gene in embryos resulted in vascular defects. Embryos treated with VEGFR2 kinase inhibitor had a similar vessel defect, suggesting that knockdown of zebrafish NRP1 reduces VEGF activity. To determine whether NRP1 and VEGF activities are interdependent in vivo, zebrafish NRP1 and VEGF morpholinos were coinjected into embryos at concentrations that individually did not significantly inhibit blood vessel development. The result was a potent inhibition of blood cell circulation via both intersegmental and axial vessels, demonstrating that VEGF and NRP1 act synergistically to promote a functional circulatory system. These results provided the first physiologic demonstration that NRP1. regulated angiogenesis through a VEGF-dependent pathway (Lee et al., Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish. Proc. Nat. Acad. Sci. 99: 10470-10475, 2002).

NID2

The protein Nidogen 2 is also known as NID2 or osteonidogen. NID2 protein is 1376 amino acids in length and has a predicted molecular weight of 151,153 daltons (but see below). NID2 is a member of the nidogen superfamily and has EGF homology; LDL receptor YWTD-containing repeat homology; and thyroglobulin type I repeat homology. The NID2 genomic sequence has been mapped to chromosomal position 14q21-q22.

Basement membranes, which are composed of type IV collagens (see NCBI MIM 120130), laminins (see LAMC1; NCBI MIM 150290), perlecan (HSPG2; NCBI MIM 142461), and nidogen (see NID1; NCBI MIM 131390), are thin pericellular protein matrices that control a large number of cellular activities, including adhesion, migration, differentiation, gene expression, and apoptosis. By sequencing several overlapping cDNA clones in both directions, a cDNA encoding NID2 was obtained Kohfeldt et al., Nidogen-2: a new basement membrane protein with diverse binding properties. J. Molec. Biol. 282: 99-109, 1998). Sequence analysis predicted that the 1,375-amino acid NID2 protein, which is 46% identical to NID1, contains a 30-residue signal peptide, 49 primarily central cys residues, 5 potential N-linked glycosylation sites, 2 tyr residues in a potential O-sulfation sequence, and a YGD rather than an RGD cell adhesion sequence. Electron microscopy confirmed the presence of 3 deduced globular domains connected by a link and a rod-like region. Additional predicted structures similar to those found in NID1 include 5 epidermal growth factor (EGF; NCBI MIM 131530)-like modules, 2 of which have potential calcium-binding sequences; 2 thyroglobulin (NCBI MIM 188450) type I modules; and 5 low density lipoprotein (LDL) receptor (NCBI MIM 606945) modules. SDS-PAGE analysis showed that NID2 is expressed as a 200-kD protein, larger than the calculated mass of 148 kD, presumably due to oligosaccharide substitution as indicated by hexosamine analysis. Northern blot analysis revealed ubiquitous expression of a 5.5-kb NID2 transcript that was strongest in heart and placenta, moderate in pancreas, kidney, and skeletal muscle, and weakest in brain. Immunoblot analysis detected expression of NID2 in muscle, heart, placenta, kidney, skin, and testis, with weaker expression in liver and brain. Immunofluorescence analysis of mouse tissues showed staining of basement membranes usually in close colocalization with NID 1.

It was determined that the mouse NID2 gene contains 21 exons (Schymeinsky et al., Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice. Molec. Cell. Biol. 22: 6820-6830, 2002). The promoter region contains several putative SP1 (NCBI MIM 189906) and CAAT recognition sites, but lacks a TATA box. Mice carrying a phenotypic null mutation in the NID2 gene have been developed. NID2-deficient mice showed no overt abnormalities, and their basement membranes appeared normal by ultrastructural analysis and immunostaining. NID2 deficiency did not lead to hemorrhages, and NID2 did not appear essential for basement membrane formation or maintenance.

ENDO180

The ENDO180 nucleotide sequence encodes a protein also known and sometimes referenced herein as UPARAP (urokinase plasminogen activator receptor-associated protein), KIAA0709, MRC2 (mannose receptor, C type 2), endocytic receptor (macrophage mannose receptor family) and is described as a novel mesenchymally expressed member of the macrophage mannose receptor family of endocytic receptors. ENDO180 is 1479 amino acids in length and has a molecular weight of about 180 kDa. ENDO180 has been mapped to chromosomal position 17q24.1.

ENDO180 is a member of the mannose receptor family (East et al., Biochim Biophys Acta. 2002 Sep. 19; 1572(2-3): 364-86. The mannose receptor family comprises four glycoproteins each of which is a type I transmembrane receptor with an N-terminal cysteine-rich domain, a single fibronectin type II (FNII) domain and eight to ten C-type lectin-like domains (CTLDs). Characteristically, these proteins are able to recycle between the plasma membrane and the endosomal apparatus due to discrete motifs present within their cytoplasmic domains. The family includes mannose receptor (MR), M-type receptor for secretory phospholipases A(2) (PLA(2)R), DEC-205/gp200-MR6 and ENDO180/uPARAP. Despite their overall structural similarity, these four receptors have evolved to use different domains to interact with discrete ligands. In addition, they differ in their ability to mediate endocytic and phagocytic events and in their intracellular destinations. Together, they represent a unique group of multidomain, multifunctional receptors.

Members of this receptor family are unusual in that they contain 8-10 C-type lectin carbohydrate recognition domains in a single polypeptide backbone, however, only the macrophage mannose receptor had been shown to function as a lectin (Sheikh et al., J Cell Sci. 2000 March; 113 (Pt 6): 1021-32). Sequence analysis of ENDO180 reveals that the second carbohydrate recognition domain has retained key conserved amino acids found in other functional C-type lectins. The protein also displays Ca(2+)-dependent binding to N-acetylglucosamine but not mannose affinity columns. ENDO180 predominantly is expressed in vivo and in vitro on fibroblasts, endothelial cells and macrophages, and the distribution and post-translational processing in these cells is consistent with ENDO180 functioning to internalize glycosylated ligands from the extracellular milieu for release in an endosomal compartment.

The uptake and lysosomal degradation of collagen by fibroblasts constitute a major pathway in the turnover of connective tissue (Engelholm, et al., J. Cell Biol. 2003 Mar. 31; 160(7): 1009-15). It was reported that ENDO180 is a key player in this process. Fibroblasts from mice with a targeted deletion in the ENDO180 gene displayed a near to complete abrogation of collagen endocytosis. These cells had diminished initial adhesion to a range of different collagens, as well as impaired migration on fibrillar collagen.

CDK10

The protein CDK10 (cyclin-dependent kinase (CDC2-like) 10) is also known as cyclin-dependent kinase 10 isoform 1 (331 amino acids); cyclin-dependent kinase 10 isoform 2 (314 amino acids); cyclin-dependent kinase 10 isoform 3 (123 amino acids); CDC2-related protein kinase; cell division protein kinase 10; cyclin-dependent kinase related protein; serine/threonine protein kinase and PISSLRE. CDK10 has been mapped to chromosomal position 16q24.

The protein encoded by CDK10 belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites. Cyclin-dependent kinases (CDKs) are CDC2 (NCBI MIM 116940)-related kinases that bind to cyclin to form active holoenzymes that play a pivotal role in the regulation of the eukaryotic cell cycle. A 360-amino acid protein PISSLRE was predicted based on the amino acid sequence of the region corresponding to the conserved CDC2 PSTAIRE motif. PISSLRE contains all the structural elements characteristic of CDKs and unique extensions at both ends. Sequence comparisons revealed that it shares 41% and 50% protein sequence identity with CDC2 and CDC2L1 (NCBI MIM 176873), respectively. It was determined that PISSLRE was expressed broadly in human tissues as a 2-kb mRNA. An additional 3.5-kb transcript was observed in some tissues (Brambilla et al., Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. Oncogene 9: 3037-3041, 1994).

FPGT

The protein FPGT (fucose-1-phosphate guanylyltransferase) is also known as GFPP and GDP-beta-L-fucose pyrophosphorylase. FPGT contains about 594 amino acids. FPGT has been mapped to chromosomal position 1p31.1.

L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. FPGT participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose.

GFPP was purified from pig kidney and a partial protein sequence was determined. Human cDNAs encoding a region similar to one of the pig GFPP peptides also were identified. Using a PCR strategy with primers based on one of the ESTs, a cDNA corresponding to the entire human GFPP coding region was cloned. The predicted GFPP protein contains 594 amino acids. When expressed in mammalian cells, the human enzyme exhibited high levels of GFPP activity. Northern blot analysis indicated that the 3.5-kb GFPP mRNA is expressed in several human tissues (Pastuszak et al., GDP-L-fucose pyrophosphorylase: purification, cDNA cloning, and properties of the enzyme. J. Biol. Chem. 273: 30165-30174, 1998).

CARK

CARK is a cardiac-specific kinase gene localized on 1p31.1. Sequence analysis suggests that CARK is a distant family member of integrin-linked kinase. Northern blot and 76-tissue array analyses showed that CARK is highly expressed in heart, but is undetectable in other tissues. Immunohistochemical analysis predominantly localized CARK in the nucleus of cardiac myocytes. In vitro kinase assay showed that CARK is a functional kinase. The yeast two-hybrid system showed that CARK could directly interact with cardiac troponin I, results that were further confirmed by coimmunoprecipitation in vivo (Zhao Y et al. J Mol Med. 2003 May; 81(5): 297-304).

PCLO

The protein PCLO is also known as piccolo (presynaptic cytomatrix protein), ACZ, KIAA0559 and aczonin. PCLO contains about 1225 amino acids. PCLO has been mapped to chromosomal position 7q11.23-q21.1.

Synaptic vesicles dock and fuse in the active zone of the plasma membrane at chemical synapses. The presynaptic cytoskeletal matrix (PCM), which is associated with the active zone and is situated between synaptic vesicles, is thought to be involved in maintaining the neurotransmitter release site in register with the postsynaptic reception apparatus. The cycling of synaptic vesicles is a multistep process involving a number of proteins (see NCBI MIM 603215). Among the components of the PCM that orchestrate these events are Bassoon (BSN; NCBI MIM 604020), RIM (RBBP8; NCBI MIM 604124), Oboe, and Piccolo.

By screening human brain cDNAs for those encoding proteins larger than 50 kD, a partial cDNA encoding PCLO, referred to as KIAA0559, was identified. RT-PCR analysis detected PCLO expression in kidney, with little or no expression in all other tissues tested (Nagase et al., Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 31-39, 1998).

By searching EST and genome databases with a murine Pclo cDNA probe, genomic sequences and a brain-specific EST (KIAA0559) encoding human PCLO were identified. Sequence analysis indicated that the deduced 4,880-amino acid rat Pclo protein is 86% identical to human PCLO. In addition, PCLO shares significant amino acid sequence homology with BSN. BSN and PCLO share 10 homology regions, or PBH regions. PBH1 and PBH2 contain 2 double-zinc finger motifs. PBH4, PBH6, and PBH8 are likely to form coiled-coil structures. At the C terminus, unlike BSN but like RIM and Oboe, PCLO contains a PDZ domain and a C2 domain. The PCLO C2 domain contains all the asp residues required for calcium binding. PCLO also contains multiple proline-rich segments. Confocal microscopy analysis of cultured hippocampal neurons showed colocalization of BSN and PCLO at identical GABAergic and glutamergic synapses, of synaptotagmin (see SYT1; NCBI MIM 185605) and PCLO along dendritic profiles, and of PCLO zinc fingers and PRA1 (NCBI MIM 604925) at nerve terminals (Fenster et al., Piccolo, a presynaptic zinc finger protein structurally related to Bassoon. Neuron 25: 203-214, 2000).

Using cAMP-GEFII (NCBI MIM 606058) as bait in a yeast 2-hybrid screen, mouse piccolo was cloned from an insulin-secreting cell line cDNA library. Northern blot analysis of mouse tissues revealed high levels in cerebrum and cerebellum and moderate levels in pituitary gland, pancreatic islets, and a pheochromocytoma-derived mouse cell line. In situ hybridization of mouse brain revealed piccolo mRNA expressed in cerebral cortex, hippocampus, olfactory bulb, cerebellar cortex, and pituitary gland. The distribution of piccolo mRNA largely overlapped that of cAMP-GEFII and Rim2 (NCBI MIM 606630) mRNA in tissues, cell lines, and mouse brain. Mouse piccolo interacts with both cAMP-GefI and Rim2. In the presence of Ca(2+), the C2A domain of piccolo could homodimerize, it could interact with the C2A domain of Rim2, or it could bind the cAMP GefII-Rim2 complex. It did not bind cAMP-GefII directly. Treatment of pancreatic islets with antisense piccolo oligonucleotides inhibited insulin secretion induced by a cAMP analog and high glucose stimulation. Piccolo serves as a Ca(2+) sensor in exocytosis in pancreatic beta cells and that the formation of a cAMP-GEFII-RIM2 piccolo complex is required (Fujimoto et al., Piccolo, a Ca(2+) sensor in pancreatic beta-cells: involvement of cAMP-GEFII-Rim2-piccolo complex in cAMP-dependent exocytosis. J. Biol. Chem. 277: 50497-50502, 2002).

By comparing the human PCLO genomic sequence with the rat Pclo cDNA, it was determined that the human PCLO gene contains at least 19 exons and spans over 350 kb.

REPS2

The protein REPS2 (RALBP1 associated Eps domain containing 2) is also known as POB1 and partner of Ral-binding protein 1. REPS2 contains about 521 amino acids. REPS2 has been mapped to chromosomal position Xp22.22.

Small G proteins have GDP-bound inactive and GTP-bound active forms; RAL proteins (e.g., RALA; NCBI MIM 179550) shift from the inactive to the active state through the actions of RALGDS (NCBI MIM 601619). RALGDS interacts with the active form of RAS (see HRAS; NCBI MIM 190020).

Using RALA-binding protein-1 (RALBP1; NCBI MIM 605801) as bait in a yeast 2-hybrid screen of a brain cDNA library, cDNAs encoding REP S2, which is designated POB 1, were identified (Ikeda et al., Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. J. Biol. Chem. 273: 814-821, 1998). Sequence analysis predicted that the 521-amino acid protein has 2 potential initiator methionines in its N terminus, a central EPS 15 (NCBI MIM 600051)-like domain, and 2 proline-rich regions and a putative coiled-coil structure in its C terminus. Northern blot analysis revealed strong expression in rat cerebrum, cerebellum, lung, and testis, with weak expression in kidney and no expression in heart, thymus, liver, spleen, or adrenal gland. Immunoprecipitation and immunoblot analyses confirmed that the C-terminal 146 amino acids of REPS2 and the C-terminal 147 residues of RALBP 1 interact in intact cells. RAL interacts with a distinct region of RALBP 1, just N terminal of the REPS2-binding domain, and both proteins can interact simultaneously with RALBP1. Immunoblot analysis established that REPS2 is tyrosine phosphorylated in response to epidermal growth factor (EGF; NCBI MIM 131530) and interacts with the EGF receptor (EGFR; NCBI MIM 131550), possibly through the adaptor protein GRB2 (NCBI MIM 108355), with which REPS2 interacts specifically.

Using nuclear magnetic resonance spectroscopy, it was shown that the EPS 15 homology domain of REPS2 consists of 2 EF-hand structures, the second of which binds calcium (Koshiba et al., Solution structure of the Eps 15 homology domain of a human POB1 (partner of RalBP1). FEBS Lett. 442: 138-142, 1999).

As used herein, “polymorphic site” refers to a region in a nucleic acid at which two or more alternative nucleotide sequences are observed in a significant number of nucleic acid samples from a population of individuals. A polymorphic site may be a nucleotide sequence of two or more nucleotides, an inserted nucleotide or nucleotide sequence, a deleted nucleotide or nucleotide sequence, or a microsatellite, for example. A polymorphic site that is two or more nucleotides in length may be 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 or more, 20 or more, 30 or more, 50 or more, 75 or more, 100 or more, 500 or more, or about 1000 nucleotides in length, where all or some of the nucleotide sequences differ within the region. A polymorphic site is often one nucleotide in length, which is referred to herein as a “single nucleotide polymorphism” or a “SNP.”

Where there are two, three, or four alternative nucleotide sequences at a polymorphic site, each nucleotide sequence is referred to as a “polymorphic variant.” Where two polymorphic variants exist, for example, the polymorphic variant represented in aminority of samples from a population is sometimes referred to as a “minor allele” and the polymorphic variant that is more prevalently represented is sometimes referred to as a “major allele.” Many organisms possess a copy of each chromosome (e.g., humans), and those individuals who possess two major alleles or two minor alleles are often referred to as being “homozygous” with respect to the polymorphism, and those individuals who possess one major allele and one minor allele are normally referred to as being “heterozygous” with respect to the polymorphism. Individuals who are homozygous with respect to one allele are sometimes predisposed to a different phenotype as compared to individuals who are heterozygous or homozygous with respect to another allele. As shown hereafter, certain polymorphic variants of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequences are associated with melanoma.

A genotype or polymorphic variant may be expressed in terms of a “haplotype,” which as used herein refers to two or more polymorphic variants occurring within genomic DNA in a group of individuals within a population. For example, two SNPs may exist within a gene where each SNP position includes a cytosine variation and an adenine variation. Certain individuals in a population may carry one allele (heterozygous) or two alleles (homozygous) having the gene with a cytosine at each SNP position. As the two cytosines corresponding to each SNP in the gene travel together on one or both alleles in these individuals, the individuals can be characterized as having a cytosine/cytosine haplotype with respect to the two SNPs in the gene.

As used herein, “phenotype” refers to a trait which can be compared between individuals, such as presence or absence of a condition, a visually observable difference in appearance between individuals, metabolic variations, physiological variations, variations in the function of biological molecules, and the like. An example of a phenotype is occurrence of melanoma.

Researchers sometimes report a polymorphic variant in a database without determining whether the variant is represented in a significant fraction of a population. Because a subset of these reported polymorphic variants are not represented in a statistically significant portion of the population, some of them are sequencing errors and/or not biologically relevant. Thus, it often is not known whether a reported polymorphic variant is statistically significant or biologically relevant until the presence of the variant is detected in a population of individuals and the frequency of the variant is determined. Methods for detecting a polymorphic variant in a population are described herein, such as in Example 2. A polymorphic variant is statistically significant and often biologically relevant if it is represented in 5% or more of a population, sometimes 10% or more, 15% or more, or 20% or more of a population, and often 25% or more, 30% or more, 35% or more, 40% or more, 45% or more, or 50% or more of a population.

A polymorphic variant may be detected on either or both strands of a double-stranded nucleic acid. Also, a polymorphic variant may be located within an intron or exon of a gene or within a portion of a regulatory region such as a promoter, a 5′ untranslated region (UTR), a 3′ UTR, and in DNA (e.g., genomic DNA (gDNA) and complementary DNA (cDNA)), RNA (e.g., mRNA, tRNA, and rRNA), or a polypeptide. Polymorphic variations may or may not result in detectable differences in gene expression, polypeptide structure, or polypeptide function.

For duplex DNA, a polymorphic variation may be reported from one strand or its complementary strand. For example, a thymine at a particular position in SEQ ID NO: 1-17 can be reported as an adenine from the complementary strand. Also, while polymorphic variations at all positions within a haplotype often are reported from the same strand orientation, polymorphic variations at certain positions within a haplotype sometimes are reported from one strand orientation while others are reported from the other. The latter sometimes occurs even though it is understood by the person of ordinary skill in the art that polymorphic variants in a haplotype occur within one strand in a nucleic acid. Where a haplotype is reported from mixed strand orientations, a person of ordinary skill in the art can determine the orientation of each polymorphic variation in the haplotype by analyzing the orientation of each extension oligonucleotide utilized to identify each polymorphic variation.

In genetic analyses that associated polymorphic variations in NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 with melanoma, samples from individuals having melanoma and individuals not having cancer were allelotyped and genotyped. The term “allelotype” as used herein refers to a process for determining the allele frequency for a polymorphic variant in pooled DNA samples from cases and controls. By pooling DNA from each group, an allele frequency for each SNP in each group is calculated. These allele frequencies are then compared to one another. Particular SNPs are considered as being associated with a particular disease when allele frequency differences calculated between case and control pools are statistically significant. The terms “genotyped” and “genotyping” as used herein refer to a process for determining a genotype of one or more individuals, where a “genotype” is a representation of one or more polymorphic variants in a nucleic acid sample from an individual or a population. It was determined that SNPs associated with an increased risk of melanoma existed in NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequences at rs1360457, rs753050, rs729647, rs8404, rs2034453, rs1044639 and rs1904528. Another polymorphic variation associated with an increased risk of melanoma was identified at rs3742536, which coded for a non-synonymous amino acid change at amino acid position 656 in a NID2 amino acid sequence (a proline or serine is encoded at this amino acid position with serine being associated with an increased risk of melanoma).

Polymorphic variants in and around the NRP1 region were tested for association with melanoma. These include polymorphic variants at positions selected from the group consisting of rs7910405, rs5784331, rs6481845, rs2065364, rs10643659, rs7896887, rs7086456, rs6481846, rs7475391, rs7477281, rs7475393, rs7475394, rs7477282, rs7475396, rs2768420, rs9418057, rs7070290, rs1360457, rs1411924, rs5784335, rs2776925, rs2776924, rs1952983, rs869636, rs869637, rs2804470, rs2776928, rs999966, rs2804475, rs4934858, rs4934863, rs4934864, rs1331326, rs1331325, rs4934871, rs4277057, rs2776930, rs1331324, rs2776932, rs4934896, rs2776933, rs4934901, rs1015300, rs2776934, rs2776935, rs2776936, rs2804491, rs2804492, rs2804493, rs2776937, rs2804494, rs4934914, rs2776922, rs2804495, rs2804496, rs4934597, rs2804497, rs2804498, rs2026319, rs1888684, rs3750733, rs4934927, rs2776946, rs4934599, rs4934934, rs2776944, rs2776943, rs2804886, rs2804900, rs2804902, rs2768397, rs2768399, rs2776941, rs2804888, rs2804499, rs2804889, rs2804891, rs2776940, rs2804897, rs2804896, rs2776939 rs2804894, rs2804501, rs2183715, rs2254822, rs2150686, rs2804893, rs2804502, rs2804892, rs2183714, rs2804503, rs1320485, rs4934603, rs2804890 and rs1854145. Polymorphic variants at the following positions in particular were associated with an increased risk of melanoma: rs6481845, rs10643659, rs7475391, rs7475394, rs7475396, rs9418057, rs1360457, rs5784335, rs1331325, rs4934871, rs2776930, rs2776935, rs2776936, rs2804491, rs2804494, rs2776922, rs2804495, rs2804496, rs1888684, rs2804888, rs2804891, rs2776940, rs2804897, rs2183714, and rs1854145. Tables in the Examples section hereafter show particular polymorphic variants indicative of a higher risk of melanoma in males and/or females. In specific embodiments, ppolymorphic variants at positions selected from the group consisting of rs7910405, rs5784331, rs6481845, rs2065364, rs10643659, rs7896887, rs7086456, rs6481846, rs7475391, rs7477281, rs7475393, rs7475394, rs7477282, rs7475396, rs2768420, rs9418057, rs7070290, rs1411924 and rs5784335 were tested for an association with increased risk of melanoma. Polymorphic variants at the following positions in particular were associated with an increased risk of melanoma: rs6481845, rs10643659, rs7475391, rs7475394, rs7475396, rs9418057, rs5784335. In particular, the following polymorphic variants were associated with risk of melanoma: a thymine at position rs6481845, a guanine-thymine-thymine-thymine deletion at position rs10643659, a cytosine at position rs7475391, a thymine at position rs7475394, a cytosine at position rs7475396, a thymine at position rs9418057 and a thymine at position rs5784335.

Variants in and around the ENDO180 region were tested for association with increased risk of melanoma. These include polymorphic variants at positions selected from the group consisting of rs2429393, rs2429392, rs2465421, rs2465410, rs2460302, rs2460301, rs2465459, rs2429391, rs2014055, rs2252814, rs8079582, rs2429390, rs7209331, rs7405815, rs4968706, rs4968613, rs729647, rs8072984, rs9896444, rs4968617, rs7350907, rs2429389, rs2460300, rs2465454, rs2465452, rs7219711, rs2465440, rs2429388, rs3786130, rs2460289, rs2465428, rs740698, rs2465425, rs2460290, rs3826537, rs3169756, rs1558237, rs2429385, rs5821368, rs8072538, rs2251393, rs2251391, rs2068657, rs8072519, rs7220505, rs2460288, rs4968736, position 16727 in SEQ ID NO: 3. Polymorphic variants at the following positions in particular were associated with an increased risk of melanoma: rs2429390, rs7209331, rs4968706, rs8072984, rs9896444, rs4968617, rs7350907, rs8072519. Tables in the Examples section hereafter show particular polymorphic variants indicative of a higher risk of melanoma in males and/or females. In particular, the following polymorphic variants were associated with risk of melanoma: a cytosine at position rs2429390, an adenine at position rs7209331, a cytosine at position rs4968706, a guanine at position rs729647, a guanine at position rs8072984, a thymine at position rs9896444, a cytosine at position rs4968617, a guanine at position rs7350907, a thymine at position rs8072519.

Polymorphic variants in and around the CDK10 region were tested for association with melanoma. These include polymorphic variants at positions selected from the group consisting of rs460879, rs460984, rs2437957, rs3815949, rs2437956, rs2437955, rs2434872, rs467357, rs258337, rs258336, rs258335, rs164752, rs154663, rs164753, rs258332, rs2010623, rs187283, rs258330, rs258328, rs459920, rs166297, rs258318, rs258317, rs171805, rs2081984, rs464586, rs460319, rs447735, rs2377058, rs604868, rs2118193, rs467035, rs2115401, rs417323, rs2377233, rs9746114, rs3751700, rs2277905, rs397891, rs3794638, rs3794637, rs258324, rs258323, rs2075880, rs258322, rs258321, rs164744, rs3833829, rs164743, rs164742, rs187282, rs465507, rs2162943, rs1946482, rs8404, rs1045814, rs4247353, rs462769, rs3803690, rs3751696, rs9972864, rs10567226, rs417414, rs154661, rs4785704, rs4785584, rs4785585, rs4785705, rs4785586, rs4785587, rs2016968, rs3751693, rs3809646, rs4785590, rs2099105, rs4785708, rs4785710, rs4785591, rs4785592, rs4785593, rs4785711, rs4785712, rs4785713, rs4785714, rs4785594, rs3803689, rs4785715, rs3764258, rs4785716, rs4785717, rs2077001, rs2377049, rs2003522, rs1230, rs1800359, rs1061646, rs1800358, rs2286392, rs2074904 and rs2074903. Polymorphic variants at the following positions in particular were associated with an increased risk of melanoma: rs460879, rs460984, rs3815949, rs2437955, rs258337, rs164752, rs164753, rs258318, rs464586, rs460319, rs2377233, rs2075880, rs258322, rs258321, rs164744, rs164743, rs164742, rs8404, rs417414, rs4785708, rs4785592, rs4785714, rs4785716 and rs1800359. Tables in the Examples section hereafter show particular polymorphic variants indicative of a higher risk of melanoma in males and/or females. In specific embodiments, polymorphic variants at positions selected from the group consisting of rs9746114, rs3833829, rs8404, rs1045814, rs3751696, rs9972864, rs10567226, position 36589 in SEQ ID NO: 4, position 44544 in SEQ ID NO: 4 and position 48304 in SEQ ID NO: 4. A polymorphic variant position rs8404, especially a cytosine at this position, was associated with an increased risk of melanoma.

Polymorphic variants in and around the FPGT and CARK regions were tested for association with melanoma. These include polymorphic variants at positions selected from the group consisting of rs1412825, rs4422957, rs3835390, rs944795, rs792310, rs526736, rs9804006, rs577367, rs575754, rs573721, rs487917, rs792307, rs476350, rs9425023, rs9425024, rs571848, rs489941, rs491623, rs956, rs520806, rs522759, rs545664, rs545721, rs536355, rs553044, rs581353, rs496008, rs7366854, rs560808, rs485929, rs477134, rs505634, rs542136, rs545680, rs522042, rs575961, rs792321, rs524306, rs495027, rs525358, rs471496, rs504866, rs532396, rs533371, rs567060, rs4650251, rs3753183, rs518769, rs474215, rs500203, rs532221, rs539534, rs531412, rs9970514, rs568049, rs9727250, rs792323, rs3765651, rs3765654, rs481387, rs483259, rs2034453, rs7536997, rs792324, rs6660350, rs492302, rs10493539, rs496720, rs570631, rs4593767, rs576802, rs518574, rs524252, rs792327, rs792328, rs2039407, rs503770, rs503904, rs514012, rs1412827, rs473834, rs480267, rs572180, rs1333029, rs485414, rs1412823, rs2027013, rs548881 and rs792329. Polymorphic variants at the following positions in particular were associated with an increased risk of melanoma: rs577367, rs487917, rs792307, rs489941, rs491623, rs536355, rs496008, rs560808, rs542136, rs524306, rs495027, rs504866, rs4650251, rs3753183, rs474215, rs500203, rs532221, rs531412, rs3765654, rs481387, rs483259, rs2034453, rs6660350, rs2039407, rs473834 and rs2027013. Tables in the Examples section hereafter show particular polymorphic variants indicative of a higher risk of melanoma in males and/or females. In specific embodiments, polymorphic variants at positions selected from the group consisting of rs3835390, rs9804006, rs9425023, rs9425024, rs489941, rs496008, rs7366854, rs4650251, rs539534, rs531412, rs9970514, rs568049, rs9727250, rs3765654, rs7536997, rs6660350, rs10493539, rs496720, position 206 in SEQ ID NO: 5, position 9261 in SEQ ID NO: 5, position 37592 in SEQ ID NO: 5. Polymorphic variants at the following positions in particular were associated with an increased risk of melanoma: rs489941, rs496008, rs4650251, rs531412, rs3765654, rs6660350, and position 206 in SEQ ID NO: 5. In particular, the following polymorphic variants were associated with risk of melanoma: an adenine at position rs489941, a thymine at position rs496008, an adenine at position rs4650251, an adenine at position rs531412, a cytosine at position rs3765654, a cytosine at position rs6660350, and a guanine at position 206 in SEQ ID NO: 5.

Polymorphic variants in and around the PCLO region were tested for association with melanoma. These include polymorphic variants at positions selected from the group consisting of rs2158220, rs1024465, rs4732483, rs4732485, rs1859176, rs1859177, rs2074401, rs4299948, rs4348435, rs4348436, rs4413718, rs985199, rs7791413, rs2522830, rs2214414, rs2189246, rs5885312, rs3064840, rs2051791, rs6467914, rs2214415, rs2189247, rs3064869, rs2522831, rs2715147, rs3064870, rs2715148, rs2522832, rs1044639, rs2715149, rs2522833, rs2247523, rs2371214, rs2189248, rs2715150, rs2715151, rs2371215, rs2715152, rs2715153, rs972346, rs2715154, rs2522834, rs2023847, rs2715155, rs2715156, rs10715043, rs2301722, rs2257207, rs2715157, rs2715158, rs2715159, rs2522835, rs2522836, rs2522837, rs2522838, rs2522839, rs2522840, rs2522841, rs10555175, rs10592258, rs2522842, rs6956848, rs2522843, rs2522844, rs2522845, rs2715161, rs6972720, rs4377905, rs4579453, rs4260846, rs1986481, rs4628206 and rs2888017. Polymorphic variants at the following positions in particular were associated with an increased risk of melanoma: rs1859176, rs2522830, rs2214414, rs2051791, rs6467914, rs2189247, rs3064869, rs2715148, rs1044639, rs2522833, rs2371214, rs2715151, rs2371215, rs2715153, rs2715154, rs2023847, rs2715155, rs2715156, rs2715157, rs2715158, rs2715159, rs2522835, rs2522837, rs10555175, rs6956848, rs2522845, rs4579453 and rs1986481. Tables in the Examples section hereafter show particular polymorphic variants indicative of a higher risk of melanoma in males and/or females. In specific embodiments, polymorphic variants at positions selected from the group consisting of rs7791413, rs2189246, rs5885312, rs3064840, rs6467914, rs3064869, rs3064870, rs10715043, rs2522841, rs10555175, rs10592258, rs6956848, rs6972720, position 53843 in SEQ ID NO: 6, position 63624 in SEQ ID NO: 6, position 65039 in SEQ ID NO: 6. Polymorphic variants at the following positions in particular were associated with an increased risk of melanoma: rs6467914, rs3064869, rs10555175, rs6956848, position 63624 in SEQ ID NO: 6, position 65039 in SEQ ID NO: 6. In particular, the following polymorphic variants were associated with risk of melanoma: a thymine at position rs6467914, an adenine at position rs3064869, a thymine at position rs10555175, a guanine at position rs6956848, position in SEQ ID NO: 6 selected from the group consisting of a guanine at position 63624 and an adenine-thymine insert at position 65039.

Polymorphic variants in and around the REPS2 region were tested for association with melanoma. These include polymorphic variants at positions selected from the group consisting of rs1904525, rs5924557, rs5924616, rs5924617, rs7883612, rs5924618, rs5924619, rs5901596, rs7878645, rs5924564, rs5924535, rs6629197, rs7060904, rs4828523, rs5924568, rs5924569, rs1904528, rs5924570, rs1904527, rs2052763, rs1549529, rs5924573, rs5901600, rs2288304, rs4240072, rs3055191, rs6632943, rs5924580, rs4828544, rs1807412, rs2010456, rs5969758, rs1965051, rs9887218, rs1426800, rs5969759, rs6527766, rs1365529, rs5924582, rs2114458, rs5924583, rs5924545, rs5969761, rs6629201, rs6629202, rs5924584, rs5924585, rs933946, rs5969762, rs713355, rs1365530, rs1961490, rs6527769, rs2006847, rs2382813, rs2033120, rs2162394, rs1346246, rs1365527, rs1426801, rs5924546, rs5924547, rs1365528, rs4828524, rs5924588, rs5969764, rs5924589, rs5924590, rs5924591, rs5924592, rs5924548, rs5924593, rs4828547, rs714070, rs5969768, rs4828526, rs5969738, rs5924595, rs5924549, rs4828528, rs5969769, rs4007744, rs2891073, rs5924599, rs1549531, rs5924601, rs5901609, rs5969739, rs5924602, rs1426798, rs7891150, rs4828550, rs5924603, rs1807947, rs954253, rs2382814, rs1896178, rs1896177, rs5924605, rs5924606, position 10537 in SEQ ID NO: 7, position 25216 in SEQ ID NO: 7 and position 119368 in SEQ ID NO: 7. Polymorphic variants at the following positions in particular were associated with an increased risk of melanoma: rs5924619, rs5924564, rs4828523, rs5924569, rs2052763, rs1549529, rs5924573, rs4240072, rs5924580, rs4828544, rs5969758, rs1965051, rs1426800, rs1365529, rs5924545, rs5969761, rs6629202, rs5924584, rs1365530, rs6527769, rs2382813, rs2033120, rs2162394, rs1346246, rs1365527, rs4828524, rs5924588, rs5969764, rs5924589, rs5924590, rs5924593, rs4828547, rs5969768, rs4828526, rs5924595, rs5924549, rs5969769, rs4007744, rs2891073, rs5924599, rs1549531, rs5924601, rs5901609, rs5969739, rs5924602, rs1426798, rs4828550, rs5924603, rs1807947, rs2382814, rs5924606, and position 25216 in SEQ ID NO: 7. Tables in the Examples section hereafter show particular polymorphic variants indicative of a higher risk of melanoma in males and/or females. In particular, the following polymorphic variants were associated with risk of melanoma: a thymine at position rs5924619, a cytosine at position rs5924564, a guanine at position rs4828523, an adenine at position rs5924569, a guanine at position rs2052763, an adenine at position rs1549529, an adenine at position rs5924573, an adenine at position rs4240072, a guanine at position rs5924580, a cytosine at position rs4828544, a guanine at position rs5969758, an adenine at position rs1965051, an adenine at position rs1426800, a cytosine at position rs1365529, an adenine at position rs5924545, a thymine at position rs5969761, a thymine at position rs6629202, a guanine at position rs5924584, a cytosine at position rs1365530, a cytosine at position rs6527769, a guanine at position rs2382813, a guanine at position rs2033120, an adenine at position rs2162394, a cytosine at position rs1346246, a cytosine at position rs1365527, an adenine at position rs4828524, a thymine at position rs5924588, a thymine at position rs5969764, a thymine at position rs5924589, a thymine at position rs5924590, a guanine at position rs5924593, a guanine at position rs4828547, a cytosine at position rs5969768, a guanine at position rs4828526, an adenine at position rs5924595, a guanine at position rs5924549, an adenine at position rs5969769, a thymine at position rs4007744, a thymine at position rs2891073, a guanine at position rs5924599, an adenine at position rs1549531, a guanine at position rs5924601, a cytosine at position rs5901609, a cytosine at position rs5969739, a thymine at position rs5924602, an adenine at position rs1426798, an adenine at position rs4828550, a thymine at position rs5924603, an adenine at position rs1807947, a thymine at position rs2382814, an adenine at position rs5924606, and an adenine at position 25216 in SEQ ID NO: 7.

The embodiments described hereafter may be directed to any of the polymorphic variants described herein. Sometimes, embodiments are directed to any of the polymorphic variants described herein with the proviso that the embodiments are not directed to a polymorphic variant at one or more positions selected from the group consisting of rs1360457, rs753050, rs729647, rs8404, rs2034453, rs1044639 and rs1904528.

Additional Polymorphic Variants Associated with Melanoma

Also provided is a method for identifying polymorphic variants proximal to an incident, founder polymorphic variant associated with melanoma. Thus, featured herein are methods for identifying a polymorphic variation associated with melanoma that is proximal to an incident polymorphic variation associated with melanoma, which comprises identifying a polymorphic variant proximal to the incident polymorphic variant associated with melanoma, where the incident polymorphic variant is in a nucleotide sequence set forth in SEQ ID NO: 1-17. The nucleotide sequence often comprises a polynucleotide sequence selected from the group consisting of (a) a polynucleotide sequence set forth in SEQ ID NO: 1-17; (b) a polynucleotide sequence that encodes a polypeptide having an amino acid sequence encoded by a nucleotide sequence set forth in SEQ ID NO: 1-17; and (c) a polynucleotide sequence that encodes a polypeptide having an amino acid sequence that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence set forth in SEQ ID NO: 1-17 or a polynucleotide sequence 90% or more identical to the polynucleotide sequence set forth in SEQ ID NO: 1-17. The presence or absence of an association of the proximal polymorphic variant with NIDDM then is determined using a known association method, such as a method described in the Examples hereafter. In an embodiment, the incident polymorphic variant is described in SEQ ID NO: 1-17 or in the Examples below. In another embodiment, the proximal polymorphic variant identified sometimes is a publicly disclosed polymorphic variant, which for example, sometimes is published in a publicly available database. In other embodiments, the polymorphic variant identified is not publicly disclosed and is discovered using a known method, including, but not limited to, sequencing a region surrounding the incident polymorphic variant in a group of nucleic samples. Thus, multiple polymorphic variants proximal to an incident polymorphic variant are associated with melanoma using this method.

The proximal polymorphic variant often is identified in a region surrounding the incident polymorphic variant. In certain embodiments, this surrounding region is about 50 kb flanking the first polymorphic variant (e.g about 50 kb 5′ of the first polymorphic variant and about 50 kb 3′ of the first polymorphic variant), and the region sometimes is composed of shorter flanking sequences, such as flanking sequences of about 40 kb, about 30 kb, about 25 kb, about 20 kb, about 15 kb, about 10 kb, about 7 kb, about 5 kb, or about 2 kb 5′ and 3′ of the incident polymorphic variant. In other embodiments, the region is composed of longer flanking sequences, such as flanking sequences of about 55 kb, about 60 kb, about 65 kb, about 70 kb, about 75 kb, about 80 kb, about 85 kb, about 90 kb, about 95 kb, or about 100 kb 5′ and 3′ of the incident polymorphic variant.

In certain embodiments, polymorphic variants associated with melanoma are identified iteratively. For example, a first proximal polymorphic variant is associated with melanoma using the methods described above and then another polymorphic variant proximal to the first proximal polymorphic variant is identified (e.g., publicly disclosed or discovered) and the presence or absence of an association of one or more other polymorphic variants proximal to the first proximal polymorphic variant with melanoma is determined.

The methods described herein are useful for identifying or discovering additional polymorphic variants that may be used to further characterize a gene, region or loci associated with a condition, a disease (e.g., melanoma), or a disorder. For example, allelotyping or genotyping data from the additional polymorphic variants may be used to identify a functional mutation or a region of linkage disequilibrium. In certain embodiments, polymorphic variants identified or discovered within a region comprising the first polymorphic variant associated with melanoma are genotyped using the genetic methods and sample selection techniques described herein, and it can be determined whether those polymorphic variants are in linkage disequilibrium with the first polymorphic variant. The size of the region in linkage disequilibrium with the first polymorphic variant also can be assessed using these genotyping methods. Thus, provided herein are methods for determining whether a polymorphic variant is in linkage disequilibrium with a first polymorphic variant associated with melanoma, and such information can be used in prognosis methods described herein.

Isolated Nucleic Acids and Variants Thereof

Featured herein are isolated NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acids, which include the nucleotide sequence of SEQ ID NO: 1-17, NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid variants, and substantially identical nucleic acids and fragments of the foregoing. Nucleotide sequences of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acids sometimes are referred to herein as “NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequences.” A “NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid variant” refers to one allele that may have one or more different polymorphic variations as compared to another allele in another subject or the same subject. A polymorphic variation in the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid variant may be represented on one or both strands in a double-stranded nucleic acid or on one chromosomal complement (heterozygous) or both chromosomal complements (homozygous). A NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid may comprise one or more polymorphic variations associated with melanoma described herein.

As used herein, the term “nucleic acid” includes DNA molecules (e.g., a complementary DNA (cDNA) and genomic DNA (gDNA)) and RNA molecules (e.g., mRNA, rRNA, siRNA and tRNA) and analogs of DNA or RNA, for example, by use of nucleotide analogs. The nucleic acid molecule can be single-stranded and it is often double-stranded. The term “isolated or purified nucleic acid” refers to nucleic acids that are separated from other nucleic acids present in the natural source of the nucleic acid. For example, with regard to genomic DNA, the term “isolated” includes nucleic acids which are separated from the chromosome with which the genomic DNA is naturally associated. An “isolated” nucleic acid is often free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5′ and/or 3′ ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated nucleic acid molecule can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of 5′ and/or 3′ nucleotide sequences which flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived. Moreover, an “isolated” nucleic acid molecule, such as a cDNA molecule, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or substantially free of chemical precursors or other chemicals when chemically synthesized. As used herein, the term “NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 gene” refers to a nucleotide sequence that encodes a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide.

In particular embodiments, a nucleic acid comprises one or more polymorphic variations independently selected from the group consisting of an adenine at position 16727 in SEQ ID NO: 3, a guanine at position 36589 in SEQ ID NO: 4, a thymine at position 44544 in SEQ ID NO: 4, a guanine at position 48304 in SEQ ID NO: 4, a guanine at position 53843 in SEQ ID NO: 6, a guanine at position 63624 in SEQ ID NO: 6, an adenine-thymine deletion at position 65039 in SEQ ID NO: 6, a guanine at position 206 in SEQ ID NO: 5, an adenine at position 9261 in SEQ ID NO: 5, a thymine at position 37592 in SEQ ID NO: 5, a guanine at position 10537 in SEQ ID NO: 7, a cytosine at position 25216 in SEQ ID NO: 7 and a thymine at position 119368 in SEQ ID NO: 7. The nucleic acid often comprises a part of or all of a nucleotide sequence in SEQ ID NO: 3, 4, 5, 6 and/or 7, and sometimes such a nucleotide sequence is a 5′ and/or 3′ sequence flanking a polymorphic variant described above that is 5, 6, 7 . . . 50, 51, 52 . . . 100, 101, 102 . . . 500, 501, 502 . . . 999 or 1000 nucleotides in length. Other embodiments are directed to methods of identifying a polymorphic variation at one or more positions in a nucleic acid (e.g., genotyping at one or more positions in the nucleic acid), where the one or more positions are independently selected from the group consisting of position 16727 in SEQ ID NO: 3, position 36589 in SEQ ID NO: 4, position 44544 in SEQ ID NO: 4, position 48304 in SEQ ID NO: 4, position 53843 in SEQ ID NO: 6, position 63624 in SEQ ID NO: 6, position 65039 in SEQ ID NO: 6, position 206 in SEQ ID NO: 5, position 9261 in SEQ ID NO: 5, position 37592 in SEQ ID NO: 5, position 10537 in SEQ ID NO: 7, position 25216 in SEQ ID NO: 7 and position 119368 in SEQ ID NO: 7.

Also included herein are nucleic acid fragments. These fragments are typically a nucleotide sequence identical to a nucleotide sequence in SEQ ID NO: 1-17, a nucleotide sequence substantially identical to a nucleotide sequence in SEQ ID NO: 1-17, or a nucleotide sequence that is complementary to the foregoing. The nucleic acid fragment may be identical, substantially identical or homologous to a nucleotide sequence in an exon or an intron in SEQ ID NO: 1-17 and may encode a full-length or mature polypeptide, or may encode a domain or part of a domain of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. Sometimes, the fragment will comprises one or more of the polymorphic variations described herein as being associated with melanoma. The nucleic acid fragment is often 50, 100, or 200 or fewer base pairs in length, and is sometimes about 300, 400, 500, 600, 700, 800, 900, 1000, 1100, 1200, 1300, or 1400 base pairs in length. A nucleic acid fragment that is complementary to a nucleotide sequence identical or substantially identical to the nucleotide sequence of SEQ ID NO: 1-17 and hybridizes to such a nucleotide sequence under stringent conditions is often referred to as a “probe.” Nucleic acid fragments often include one or more polymorphic sites, or sometimes have an end that is adjacent to a polymorphic site as described hereafter.

An example of a nucleic acid fragment is an oligonucleotide. As used herein, the term “oligonucleotide” refers to a nucleic acid comprising about 8 to about 50 covalently linked nucleotides, often comprising from about 8 to about 35 nucleotides, and more often from about 10 to about 25 nucleotides. The backbone and nucleotides within an oligonucleotide may be the same as those of naturally occurring nucleic acids, or analogs or derivatives of naturally occurring nucleic acids, provided that oligonucleotides having such analogs or derivatives retain the ability to hybridize specifically to a nucleic acid comprising a targeted polymorphism. Oligonucleotides described herein may be used as hybridization probes or as components of prognostic or diagnostic assays, for example, as described herein.

Oligonucleotides are typically synthesized using standard methods and equipment, such as the ABI™3900 High Throughput DNA Synthesizer and the EXPEDITE™ 8909 Nucleic Acid Synthesizer, both of which are available from Applied Biosystems (Foster City, Calif.). Analogs and derivatives are exemplified in U.S. Pat. Nos. 4,469,863; 5,536,821; 5,541,306; 5,637,683; 5,637,684; 5,700,922; 5,717,083; 5,719,262; 5,739,308; 5,773,601; 5,886,165; 5,929,226; 5,977,296; 6,140,482; WO 00/56746; WO 01/14398, and related publications. Methods for synthesizing oligonucleotides comprising such analogs or derivatives are disclosed, for example, in the patent publications cited above and in U.S. Pat. Nos. 5,614,622; 5,739,314; 5,955,599; 5,962,674; 6,117,992; in WO 00/75372; and in related publications.

Oligonucleotides may also be linked to a second moiety. The second moiety may be an additional nucleotide sequence such as a tail sequence (e.g., a polyadenosine tail), an adapter sequence (e.g., phage M13 universal tail sequence), and others. Alternatively, the second moiety may be a non-nucleotide moiety such as a moiety which facilitates linkage to a solid support or a label to facilitate detection of the oligonucleotide. Such labels include, without limitation, a radioactive label, a fluorescent label, a chemiluminescent label, a paramagnetic label, and the like. The second moiety may be attached to any position of the oligonucleotide, provided the oligonucleotide can hybridize to the nucleic acid comprising the polymorphism.

Uses for Nucleic Acids

Nucleic acid coding sequences depicted in SEQ ID NO: 1-17, or substantially identical sequences thereof, may be used for diagnostic purposes for detection and control of polypeptide expression. Also, included are oligonucleotide sequences such as antisense nucleic acids (e.g., DNA, RNA or PNA), inhibitory RNA and small-interfering RNA (siRNA), and ribozymes that function to inhibit translation of a polypeptide. Antisense techniques and RNA interference techniques are known in the art and are described herein.

Ribozymes are enzymatic RNA molecules capable of catalyzing the specific cleavage of RNA. The mechanism of ribozyme action involves sequence specific hybridization of the ribozyme molecule to complementary target RNA, followed by endonucleolytic cleavage. For example, hammerhead motif ribozyme molecules may be engineered that specifically and efficiently catalyze endonucleolytic cleavage of RNA sequences encoded by a nucleotide sequence set forth in SEQ ID NO: 1-17 or a substantially identical sequence thereof. Specific ribozyme cleavage sites within any potential RNA target are initially identified by scanning the target molecule for ribozyme cleavage sites which include the following sequences, GUA, GUU and GUC. Once identified, short RNA sequences of between fifteen (15) and twenty (20) ribonucleotides corresponding to the region of the target gene containing the cleavage site may be evaluated for predicted structural features such as secondary structure that may render the oligonucleotide sequence unsuitable. The suitability of candidate targets may also be evaluated by testing their accessibility to hybridization with complementary oligonucleotides, using ribonuclease protection assays.

Antisense RNA and DNA molecules, siRNA and ribozymes may be prepared by any method known in the art for the synthesis of RNA molecules. These include techniques for chemically synthesizing oligodeoxyribonucleotides well known in the art such as solid phase phosphoramidite chemical synthesis. Alternatively, RNA molecules may be generated by in vitro and in vivo transcription of DNA sequences encoding the antisense RNA molecule. Such DNA sequences may be incorporated into a wide variety of vectors which incorporate suitable RNA polymerase promoters such as the T7 or SP6 polymerase promoters. Alternatively, antisense cDNA constructs that synthesize antisense RNA constitutively or inducibly, depending on the promoter used, can be introduced stably into cell lines.

DNA encoding a polypeptide also may have a number of uses for the diagnosis of diseases, including melanoma, resulting from aberrant expression of a target gene described herein. For example, the nucleic acid sequence may be used in hybridization assays of biopsies or autopsies to diagnose abnormalities of expression or function (e.g., Southern or Northern blot analysis, in situ hybridization assays).

In addition, the expression of a polypeptide during embryonic development may also be determined using nucleic acid encoding the polypeptide. As addressed, infra, production of functionally impaired polypeptide is the cause of various disease states, melanoma. In situ hybridizations using polypeptide as a probe may be employed to predict problems related to melanoma. Further, as indicated, infra, administration of human active polypeptide, recombinantly produced as described herein, may be used to treat disease states related to functionally impaired polypeptide. Alternatively, gene therapy approaches may be employed to remedy deficiencies of functional polypeptide or to replace or compete with dysfunctional polypeptide.

Expression Vectors, Host Cells, and Genetically Engineered Cells

Provided herein are nucleic acid vectors, often expression vectors, which contain a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid. As used herein, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked and can include a plasmid, cosmid, or viral vector. The vector can be capable of autonomous replication or it can integrate into a host DNA. Viral vectors may include replication defective retroviruses, adenoviruses and adeno-associated viruses for example.

A vector can include a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid in a form suitable for expression of the nucleic acid in a host cell. The recombinant expression vector typically includes one or more regulatory sequences operatively linked to the nucleic acid sequence to be expressed. The term “regulatory sequence” includes promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Regulatory sequences include those that direct constitutive expression of a nucleotide sequence, as well as tissue-specific regulatory and/or inducible sequences. The design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of polypeptide desired, and the like. Expression vectors can be introduced into host cells to produce NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides, including fusion polypeptides, encoded by NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acids.

Recombinant expression vectors can be designed for expression of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides in prokaryotic or eukaryotic cells. For example, NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides can be expressed in E. coli, insect cells (e.g., using baculovirus expression vectors), yeast cells, or mammalian cells. Suitable host cells are discussed further in Goeddel, Gene Expression Technology: Methods in Enzymology 185, Academic Press, San Diego, Calif. (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.

Expression of polypeptides in prokaryotes is most often carried out in E. coli with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion polypeptides. Fusion vectors add a number of amino acids to a polypeptide encoded therein, usually to the amino terminus of the recombinant polypeptide. Such fusion vectors typically serve three purposes: 1) to increase expression of recombinant polypeptide; 2) to increase the solubility of the recombinant polypeptide; and 3) to aid in the purification of the recombinant polypeptide by acting as a ligand in affinity purification. Often, a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant polypeptide to enable separation of the recombinant polypeptide from the fusion moiety subsequent to purification of the fusion polypeptide. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase. Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith & Johnson, Gene 67: 31-40 (1988)), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) which fuse glutathione S-transferase (GST), maltose E binding polypeptide, or polypeptide A, respectively, to the target recombinant polypeptide.

Purified fusion polypeptides can be used in screening assays and to generate antibodies specific for NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides. In a therapeutic embodiment, fusion polypeptide expressed in a retroviral expression vector is used to infect bone marrow cells that are subsequently transplanted into irradiated recipients. The pathology of the subject recipient is then examined after sufficient time has passed (e.g., six (6) weeks).

Expressing the polypeptide in host bacteria with an impaired capacity to proteolytically cleave the recombinant polypeptide is often used to maximize recombinant polypeptide expression (Gottesman, S., Gene Expression Technology: Methods in Enzymology, Academic Press, San Diego, Calif. 185: 119-128 (1990)). Another strategy is to alter the nucleotide sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in E. coli (Wada et al., Nucleic Acids Res. 20: 2111-2118 (1992)). Such alteration of nucleotide sequences can be carried out by standard DNA synthesis techniques.

When used in mammalian cells, the expression vector's control functions are often provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40. Recombinant mammalian expression vectors are often capable of directing expression of the nucleic acid in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Non-limiting examples of suitable tissue-specific promoters include an albumin promoter (liver-specific; Pinkert et al., Genes Dev. 1: 268-277 (1987)), lymphoid-specific promoters (Calame & Eaton, Adv. Immunol. 43: 235-275 (1988)), promoters of T cell receptors (Winoto & Baltimore, EMBO J. 8: 729-733 (1989)) promoters of immunoglobulins (Banerji et al., Cell 33: 729-740 (1983); Queen & Baltimore, Cell 33: 741-748 (1983)), neuron-specific promoters (e.g., the neurofilament promoter; Byrne & Ruddle, Proc. Natl. Acad. Sci. USA 86: 5473-5477 (1989)), pancreas-specific promoters (Edlund et al., Science 230: 912-916 (1985)), and mammary gland-specific promoters (e.g., milk whey promoter; U.S. Pat. No. 4,873,316 and European Application Publication No. 264,166). Developmentally-regulated promoters are sometimes utilized, for example, the murine hox promoters (Kessel & Gruss, Science 249: 374-379 (1990)) and the a-fetopolypeptide promoter (Campes & Tilghman, Genes Dev. 3: 537-546 (1989)).

A NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid may also be cloned into an expression vector in an antisense orientation. Regulatory sequences (e.g., viral promoters and/or enhancers) operatively linked to a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid cloned in the antisense orientation can be chosen for directing constitutive, tissue specific or cell type specific expression of antisense RNA in a variety of cell types. Antisense expression vectors can be in the form of a recombinant plasmid, phagemid or attenuated virus. For a discussion of the regulation of gene expression using antisense genes see Weintraub et al., Antisense RNA as a molecular tool for genetic analysis, Reviews—Trends in Genetics, Vol. 1(1) (1986).

Also provided herein are host cells that include a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid within a recombinant expression vector or NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid sequence fragments which allow it to homologously recombine into a specific site of the host cell genome. The terms “host cell” and “recombinant host cell” are used interchangeably herein. Such terms refer not only to the particular subject cell but rather also to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein. A host cell can be any prokaryotic or eukaryotic cell. For example, a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide can be expressed in bacterial cells such as E. coli, insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those skilled in the art.

Vectors can be introduced into host cells via conventional transformation or transfection techniques. As used herein, the terms “transformation” and “transfection” are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g., DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, transduction/infection, DEAE-dextran-mediated transfection, lipofection, or electroporation.

A host cell provided herein can be used to produce (i.e., express) a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. Accordingly, further provided are methods for producing a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide using the host cells described herein. In one embodiment, the method includes culturing host cells into which a recombinant expression vector encoding a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide has been introduced in a suitable medium such that a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide is produced. In another embodiment, the method further includes isolating a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide from the medium or the host cell.

Also provided are cells or purified preparations of cells which include a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 transgene, or which otherwise misexpress NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. Cell preparations can consist of human or non-human cells, e.g., rodent cells, e.g., mouse or rat cells, rabbit cells, or pig cells. In embodiments, the cell or cells include a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 transgene (e.g., a heterologous form of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 such as a human gene expressed in non-human cells). The NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 transgene can be misexpressed, e.g., overexpressed or underexpressed. In other embodiments, the cell or cells include a gene which misexpress an endogenous NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide (e.g., expression of a gene is disrupted, also known as a knockout). Such cells can serve as a model for studying disorders which are related to mutated or mis-expressed NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 alleles or for use in drug screening. Also provided are human cells (e.g., a hematopoietic stem cells) transformed with a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid.

Also provided are cells or a purified preparation thereof (e.g., human cells) in which an endogenous NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid is under the control of a regulatory sequence that does not normally control the expression of the endogenous NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 gene. The expression characteristics of an endogenous gene within a cell (e.g., a cell line or microorganism) can be modified by inserting a heterologous DNA regulatory element into the genome of the cell such that the inserted regulatory element is operably linked to the endogenous NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 gene. For example, an endogenous NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 gene (e.g., a gene which is “transcriptionally silent,” not normally expressed, or expressed only at very low levels) may be activated by inserting a regulatory element which is capable of promoting the expression of a normally expressed gene product in that cell. Techniques such as targeted homologous recombinations, can be used to insert the heterologous DNA as described in, e.g., Chappel, U.S. Pat. No. 5,272,071; WO 91/06667, published on May 16, 1991.

Transgenic Animals

Non-human transgenic animals that express a heterologous NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide (e.g., expressed from a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid isolated from another organism) can be generated. Such animals are useful for studying the function and/or activity of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide and for identifying and/or evaluating modulators of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid and NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide activity. As used herein, a “transgenic animal” is a non-human animal such as a mammal (e.g., a non-human primate such as chimpanzee, baboon, or macaque; an ungulate such as an equine, bovine, or caprine; or a rodent such as a rat, a mouse, or an Israeli sand rat), a bird (e.g., a chicken or a turkey), an amphibian (e.g., a frog, salamander, or newt), or an insect (e.g., Drosophila melanogaster), in which one or more of the cells of the animal includes a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 transgene. A transgene is exogenous DNA or a rearrangement (e.g., a deletion of endogenous chromosomal DNA) that is often integrated into or occurs in the genome of cells in a transgenic animal. A transgene can direct expression of an encoded gene product in one or more cell types or tissues of the transgenic animal, and other transgenes can reduce expression (e.g., a knockout). Thus, a transgenic animal can be one in which an endogenous NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 gene has been altered by homologous recombination between the endogenous gene and an exogenous DNA molecule introduced into a cell of the animal (e.g., an embryonic cell of the animal) prior to development of the animal.

Intronic sequences and polyadenylation signals can also be included in the transgene to increase expression efficiency of the transgene. One or more tissue-specific regulatory sequences can be operably linked to a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 transgene to direct expression of a NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide to particular cells. A transgenic founder animal can be identified based upon the presence of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 transgene in its genome and/or expression of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene encoding a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide can further be bred to other transgenic animals carrying other transgenes.

NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides can be expressed in transgenic animals or plants by introducing, for example, a nucleic acid encoding the polypeptide into the genome of an animal. In embodiments the nucleic acid is placed under the control of a tissue specific promoter, e.g., a milk or egg specific promoter, and recovered from the milk or eggs produced by the animal. Also included is a population of cells from a transgenic animal.

NRP1. NID2. ENDO180. CDK10. FPGT. CARK, PCLO or REPS2 Polypeptides

Also featured herein are isolated NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides, including proteins and peptides, that include an amino acid sequence set forth in SEQ ID NO: 18-27, or a substantially identical sequence thereof or variant thereof. In an embodiment, an NID2 polypeptide includes a serine at amino acid position 656. Isolated NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides featured herein include both the full-length polypeptide and the mature polypeptide (i.e., the polypeptide minus the signal sequence or propeptide domain). A NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide is a polypeptide encoded by a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid, where one nucleic acid can encode one or more different polypeptides. An “isolated” or “purified” polypeptide or protein is substantially free of cellular material or other contaminating proteins from the cell or tissue source from which the protein is derived, or substantially free from chemical precursors or other chemicals when chemically synthesized. In one embodiment, the language “substantially free” means preparation of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide variant having less than about 30%, 20%, 10% and more preferably 5% (by dry weight), of non-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide (also referred to herein as a “contaminating protein”), or of chemical precursors or non-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 chemicals. When the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or a biologically active portion thereof is recombinantly produced, it is also preferably substantially free of culture medium, specifically, where culture medium represents less than about 20%, sometimes less than about 10%, and often less than about 5% of the volume of the polypeptide preparation. Isolated or purified NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide preparations are sometimes 0.01 milligrams or more or 0.1 milligrams or more, and often 1.0 milligrams or more and 10 milligrams or more in dry weight.

Further included herein are NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide fragments. The polypeptide fragment may be a domain or part of a domain of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK PCLO or REPS2 polypeptide. The polypeptide fragment may have increased, decreased or unexpected biological activity. The polypeptide fragment is often 50 or fewer, 100 or fewer, or 200 or fewer amino acids in length, and is sometimes 300, 400, 500, 600, or 700, or fewer amino acids in length. A fragment sometimes includes a substantial portion of a domain, examples of which are described herein.

Substantially identical polypeptides may depart from the amino acid sequences set forth in SEQ ID NO: 18-27 in different manners. For example, conservative amino acid modifications may be introduced at one or more positions in the amino acid sequences of SEQ ID NO: 18-27. A “conservative amino acid substitution” is one in which the amino acid is replaced by another amino acid having a similar structure and/or chemical function. Families of amino acid residues having similar structures and functions are well known. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Also, essential and non-essential amino acids may be replaced. A “non-essential” amino acid is one that can be altered without abolishing or substantially altering the biological function of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, whereas altering an “essential” amino acid abolishes or substantially alters the biological function of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. Amino acids that are conserved among NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides are typically essential amino acids.

Also, NRP1, NID2, ENDO180, CDK10, FPGT, CARK PCLO or REPS2 polypeptides and polypeptide variants may exist as chimeric or fusion polypeptides. As used herein, a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 “chimeric polypeptide” or “fusion polypeptide” includes a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide linked to a non-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. A “non-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide” refers to a polypeptide having an amino acid sequence corresponding to a polypeptide which is not substantially identical to the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, which includes, for example, a polypeptide that is different from the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide and derived from the same or a different organism. The NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide in the fusion polypeptide can correspond to an entire or nearly entire NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or a fragment thereof. The non-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide can be fused to the N-terminus or C-terminus of the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide.

Fusion polypeptides can include a moiety having high affinity for a ligand. For example, the fusion polypeptide can be a GST-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 fusion polypeptide in which the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 sequences are fused to the C-terminus of the GST sequences, or a polyhistidine-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 fusion polypeptide in which the NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide is fused at the N- or C-terminus to a string of histidine residues. Such fusion polypeptides can facilitate purification of recombinant NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2. Expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide), and a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid can be cloned into an expression vector such that the fusion moiety is linked in-frame to the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. Further, the fusion polypeptide can be a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide containing a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), expression, secretion, cellular internalization, and cellular localization of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide can be increased through use of a heterologous signal sequence. Fusion polypeptides can also include all or a part of a serum polypeptide (e.g., an IgG constant region or human serum albumin).

NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides or fragments thereof can be incorporated into pharmaceutical compositions and administered to a subject in vivo. Administration of these NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides can be used to affect the bioavailability of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 substrate and may effectively increase NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 biological activity in a cell. NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 fusion polypeptides may be useful therapeutically for the treatment of disorders caused by, for example, (i) aberrant modification or mutation of a gene encoding a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide; (ii) mis-regulation of the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 gene; and (iii) aberrant post-translational modification of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. Also, NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides can be used as immunogens to produce anti-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antibodies in a subject, to purify NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 ligands or binding partners, and in screening assays to identify molecules which inhibit or enhance the interaction of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 with a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 substrate.

In addition, polypeptides can be chemically synthesized using techniques known in the art (See, e.g., Creighton, 1983 Proteins. New York, N.Y.: W. H. Freeman and Company; and Hunkapiller et al., (1984) Nature July 12-18; 310(5973): 105-11). For example, a relative short fragment can be synthesized by use of a peptide synthesizer. Furthermore, if desired, nonclassical amino acids or chemical amino acid analogs can be introduced as a substitution or addition into the fragment sequence. Nonclassical amino acids or chemical amino acid analogs include but are not limited to ornithine (hereinafter referred to as Z), diaminobutyric acid (hereinafter referred to as B), norleucine (hereinafter referred to as O), pyrylalanine, thienylalanine, naphthylalanine and phenylglycine. Other examples of non-naturally occurring amino acids and non-classical amino acid replacements are alpha* and alpha-disubstituted* amino acids, N-alkyl amino acids*, lactic acid*, halide derivatives of natural amino acids such as trifluorotyrosine*, p-Cl-phenylalanine*, p-Br-phenylalanine*, p-I-phenylalanine*, L-allyl-glycine*, beta-alanine*, L-alpha-amino butyric acid*, L-gamma-amino butyric acid*, L-alpha-amino isobutyric acid*, L-epsilon-amino caproic acid#, 7-amino heptanoic acid*, L-methionine sulfone*, L-norleucine*, L-norvaline*, p-nitro-L-phenylalanine*, L-hydroxyproline#, L-thioproline*, methyl derivatives of phenylalanine (Phe) such as 4-methyl-Phe*, pentamethyl-Phe*, L-Phe (4-amino)#, L-Tyr (methyl)*, L-Phe (4-isopropyl)*, L-Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxyl acid)*, L-diaminopropionic acid, L-Phe (4-benzyl)*, 2,4-diaminobutyric acid, 4-aminobutyric acid (gamma-Abu), 2-amino butyric acid (alpha-Abu), 6-amino hexanoic acid (epsilon-Ahx), 2-amino isobutyric acid (Aib), 3-amino propionic acid, ornithine, norleucine, norvaline, hydroxyproline, sarcosine, citrulline, homocitrulline, cysteic acid, t-butylglycine, t-butylalanine, phenylglycine, cyclohexylalanine, fluoroamino acids, designer amino acids such as beta-methyl amino acids, Ca-methyl amino acids, Na-methyl amino acids, naphthyl alanine, amino acid analogs in general and the like. The notation * indicates a derivative having hydrophobic characteristics, # indicates a derivative having hydrophilic characteristics, and #* indicates a derivative having amphipathic characteristics.

Polypeptides and polypeptide fragments sometimes are differentially modified during or after translation, e.g., by glycosylation, acetylation, phosphorylation, amidation, derivatization by known protecting/blocking groups, proteolytic cleavage, linkage to an antibody molecule or other cellular ligand, etc. Any of numerous chemical modifications may be carried out by known techniques, including but not limited, to specific chemical cleavage by cyanogen bromide, trypsin, chymotrypsin, papain, V8 protease, NaBH4; acetylation, formylation, oxidation, reduction; metabolic synthesis in the presence of tunicamycin; and the like. Additional post-translational modifications include, for example, N-linked or O-linked carbohydrate chains, processing of N-terminal or C-terminal ends), attachment of chemical moieties to the amino acid backbone, chemical modifications of N-linked or O-linked carbohydrate chains, and addition or deletion of an N-terminal methionine residue as a result of procaryotic host cell expression. The polypeptide fragments may also be modified with a detectable label, such as an enzymatic, fluorescent, isotopic or affinity label to allow for detection and isolation of the polypeptide.

Also provided are chemically modified derivatives of polypeptides that can provide additional advantages such as increased solubility, stability and circulating time of the polypeptide, or decreased immunogenicity (see e.g., U.S. Pat. No. 4,179,337). The chemical moieties for derivitization may be selected from water soluble polymers such as polyethylene glycol, ethylene glycol/propylene glycol copolymers, carboxymethylcellulose, dextran, polyvinyl alcohol and the like. The polypeptides may be modified at random positions within the molecule, or at predetermined positions within the molecule and may include one, two, three or more attached chemical moieties.

The polymer may be of any molecular weight, and may be branched or unbranched. For polyethylene glycol, the molecular weight often utilized is between about 1 kDa and about 100 kDa (the term “about” indicating that in preparations of polyethylene glycol, some molecules will weigh more, some less, than the stated molecular weight) for ease in handling and manufacturing. Other sizes may be used, depending on the desired therapeutic profile (e.g., the duration of sustained release desired, the effects, if any on biological activity, the ease in handling, the degree or lack of antigenicity and other known effects of the polyethylene glycol to a therapeutic protein or analog).

The polymers should be attached to the polypeptide with consideration of effects on functional or antigenic domains of the polypeptide. There are a number of attachment methods available to those skilled in the art (e.g., EP 0 401 384 (coupling PEG to G-CSF) and Malik et al. (1992) Exp Hematol. September; 20(8): 1028-35 (pegylation of GM-CSF using tresyl chloride)). For example, polyethylene glycol may be covalently bound through amino acid residues via a reactive group, such as a free amino or carboxyl group. Reactive groups are those to which an activated polyethylene glycol molecule may be bound. The amino acid residues having a free amino group may include lysine residues and the N-terminal amino acid residues; those having a free carboxyl group may include aspartic acid residues, glutamic acid residues and the C-terminal amino acid residue. Sulfhydryl groups may also be used as a reactive group for attaching the polyethylene glycol molecules. For therapeutic purposes, the attachment sometimes is at an amino group, such as attachment at the N-terminus or lysine group.

Proteins can be chemically modified at the N-terminus. Using polyethylene glycol as an illustration of such a composition, one may select from a variety of polyethylene glycol molecules (by molecular weight, branching, etc.), the proportion of polyethylene glycol molecules to protein (polypeptide) molecules in the reaction mix, the type of pegylation reaction to be performed, and the method of obtaining the selected N-terminally pegylated protein. The method of obtaining the N-terminally pegylated preparation (i.e., separating this moiety from other monopegylated moieties if necessary) may be by purification of the N-terminally pegylated material from a population of pegylated protein molecules. Selective proteins chemically modified at the N-terminus may be accomplished by reductive alkylation, which exploits differential reactivity of different types of primary amino groups (lysine versus the N-terminal) available for derivatization in a particular protein. Under the appropriate reaction conditions, substantially selective derivatization of the protein at the N-terminus with a carbonyl group containing polymer is achieved.

Substantially Identical NRP1, NID2. ENDO180. CDK10. FPGT. CARK, PCLO or REPS2 Nucleic Acids and Polypeptides

Nucleotide sequences and polypeptide sequences that are substantially identical to the nucleotide sequence of SEQ ID NO: 1-17 and the polypeptide sequences of SEQ ID NO: 18-27 are included herein. The term “substantially identical” as used herein refers to two or more nucleic acids or polypeptides sharing one or more identical nucleotide sequences or polypeptide sequences, respectively. Included are nucleotide sequences or polypeptide sequences that are 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95% or more (each often within a 1%, 2%, 3% or 4% variability) identical to the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence in SEQ ID NO: 1-17 or the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide sequences of SEQ ID NO: 18-27. One test for determining whether two nucleic acids are substantially identical is to determine the percent of identical nucleotide sequences or polypeptide sequences shared between the nucleic acids or polypeptides.

Calculations of sequence identity are often performed as follows. Sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). The length of a reference sequence aligned for comparison purposes is sometimes 30% or more, 40% or more, 50% or more, often 60% or more, and more often 70%, 80%, 90%, 100% of the length of the reference sequence. The nucleotides or amino acids at corresponding nucleotide or polypeptide positions, respectively, are then compared among the two sequences. When a position in the first sequence is occupied by the same nucleotide or amino acid as the corresponding position in the second sequence, the nucleotides or amino acids are deemed to be identical at that position. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, introduced for optimal alignment of the two sequences.

Comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. Percent identity between two amino acid or nucleotide sequences can be determined using the algorithm of Meyers & Miller, CABIOS 4: 11-17 (1989), which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4. Also, percent identity between two amino acid sequences can be determined using the Needleman & Wunsch, J. Mol. Biol. 48: 444-453 (1970) algorithm which has been incorporated into the GAP program in the GCG software package (available at the http address www.gcg.com), using either a Blossum 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6. Percent identity between two nucleotide sequences can be determined using the GAP program in the GCG software package (available at http address www.gcg.com), using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, 4, 5, or 6. A set of parameters often used is a Blossum 62 scoring matrix with a gap open penalty of 12, a gap extend penalty of 4, and a frameshift gap penalty of 5.

Another manner for determining if two nucleic acids are substantially identical is to assess whether a polynucleotide homologous to one nucleic acid will hybridize to the other nucleic acid under stringent conditions. As use herein, the term “stringent conditions” refers to conditions for hybridization and washing. Stringent conditions are known to those skilled in the art and can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y., 6.3.1-6.3.6 (1989). Aqueous and non-aqueous methods are described in that reference and either can be used. An example of stringent hybridization conditions is hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 50° C. Another example of stringent hybridization conditions are hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 55° C. A further example of stringent hybridization conditions is hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 60° C. Often, stringent hybridization conditions are hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 65° C. More often, stringency conditions are 0.5M sodium phosphate, 7% SDS at 65° C., followed by one or more washes at 0.2×SSC, 1% SDS at 65° C.

An example of a substantially identical nucleotide sequence to SEQ ID NO: 1-17 is one that has a different nucleotide sequence and still encodes a polypeptide sequence set forth in SEQ ID NO: 18-25. Another example is a nucleotide sequence that encodes a polypeptide having a polypeptide sequence that is more than 70% identical to, sometimes more than 75%, 80%, or 85% identical to, and often more than 90% and 95% or more identical to the polypeptide sequences set forth in SEQ ID NO: 18-25.

NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequences and polypeptide sequences can be used as “query sequences” to perform a search against public databases to identify other family members or related sequences, for example. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul et al., J. Mol. Biol. 215: 403-10 (1990). BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid molecules. BLAST polypeptide searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al., Nucleic Acids Res. 25(17): 3389-3402 (1997). When utilizing BLAST and Gapped BLAST programs, default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used (see the http address www.ncbi.nlm.nih.gov).

A nucleic acid that is substantially identical to the nucleotide sequence of SEQ ID NO: 1-17 may include polymorphic sites at positions equivalent to those described herein (e.g., position 32137 in SEQ ID NO: 1) when the sequences are aligned. For example, using the alignment procedures described herein, SNPs in a sequence substantially identical to the sequence of SEQ ID NO: 1-17 can be identified at nucleotide positions that match (i.e., align) with nucleotides at SNP positions in SEQ ID NO: 1-17. Also, where a polymorphic variation is an insertion or deletion, insertion or deletion of a nucleotide sequence from a reference sequence can change the relative positions of other polymorphic sites in the nucleotide sequence.

Substantially identical NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide and polypeptide sequences include those that are naturally occurring, such as allelic variants (same locus), splice variants, homologs (different locus), and orthologs (different organism) or can be non-naturally occurring. Non-naturally occurring variants can be generated by mutagenesis techniques, including those applied to polynucleotides, cells, or organisms. The variants can contain nucleotide substitutions, deletions, inversions and insertions. Variation can occur in either or both the coding and non-coding regions. The variations can produce both conservative and non-conservative amino acid substitutions (as compared in the encoded product). Orthologs, homologs, allelic variants, and splice variants can be identified using methods known in the art. These variants normally comprise a nucleotide sequence encoding a polypeptide that is 50%, about 55% or more, often about 70-75% or more, more often about 80-85% or more, and typically about 90-95% or more identical to the amino acid sequences shown in SEQ ID NO: 18-27 or a fragment thereof. Such nucleic acid molecules can readily be identified as being able to hybridize under stringent conditions to the nucleotide sequence shown in SEQ ID NO: 1-17 or a fragment of this sequence. Nucleic acid molecules corresponding to orthologs, homologs, and allelic variants of the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence can further be identified by mapping the sequence to the same chromosome or locus as the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence or variant.

Also, substantially identical NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequences may include codons that are altered with respect to the naturally occurring sequence for enhancing expression of a NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or polypeptide variant in a particular expression system. For example, the nucleic acid can be one in which one or more codons are altered, and often 10% or more or 20% or more of the codons are altered for optimized expression in bacteria (e.g., E. coli.), yeast (e.g., S. cervesiae), human (e.g., 293 cells), insect, or rodent (e.g., hamster) cells.

Methods for Identifying Subjects at Risk of Melanoma and Risk of Melanoma

Methods for determining whether a subject is at risk of melanoma are provided herein. These methods include detecting the presence or absence of one or more polymorphic variations associated with melanoma in a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence, or substantially identical sequence thereof, in a sample from a subject, where the presence of such a polymorphic variation is indicative of the subject being at risk of melanoma. These genetic tests are useful for prognosing and/or diagnosing melanoma and often are useful for determining whether an individual is at an increased, intermediate or decreased risk of developing or having melanoma.

Thus, featured herein is a method for identifying a subject at risk of melanoma, which comprises detecting in a nucleic acid sample from the subject the presence or absence of a polymorphic variation associated with melanoma at a polymorphic site in a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence. The nucleotide sequence often is selected from the group consisting of: (a) a nucleotide sequence of SEQ ID NO: 1-17; (b) a nucleotide sequence which encodes a polypeptide consisting of the amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1-17; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to the amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1-17; and (d) a fragment of a nucleotide sequence of (a), (b), or (c), where the fragment often comprises a polymorphic site; whereby the presence of the polymorphic variation is indicative of the subject being at risk of melanoma. A polymorphic variation assayed in the genetic test often is located in an intron, sometimes in a region surrounding the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 open reading frame (e.g., within 50 kilobases (kb), 40 kb, 30 kb, 20 kb, 15, kb, 10 kb, 5 kb, 4 kb, 3 kb, 2 kb, or 1 kb of the open reading frame initiation site or termination site), and sometimes in an exon. Sometimes the polymorphic variation is not located in an exon (e.g., it sometimes is located in an intron or region upstream or downstream of a terminal intron or exon). As used herein, “SEQ ID NO: 1-17” refers to individual sequences in SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 or 17, each sequence being separately applicable to embodiments described herein.

Results from such genetic tests may be combined with other test results to diagnose melanoma. For example, genetic test results may be gathered, a patient sample may be ordered based on a determined predisposition to melanoma (e.g., a skin biopsy), the patient sample is analyzed, and the results of the analysis may be utilized to diagnose melanoma. Also, melanoma diagnostic tests are generated by stratifying populations into subpopulations having different progressions of melanoma and detecting polymorphic variations associated with different progressions of the melanoma, as described in further detail hereafter. In another embodiment, genetic test results are gathered, a patient's risk factors for developing melanoma are analyzed (e.g., exposure to sun and skin pigmentation), and a patient sample may be ordered based on a determined risk of melanoma.

Risk of melanoma sometimes is expressed as a probability, such as an odds ratio, percentage, or risk factor. The risk assessment is based upon the presence or absence of one or more polymorphic variants described herein, and also may be based in part upon phenotypic traits of the individual being tested. Methods for calculating risks based upon patient data are well known (see, e.g., Agresti, Categorical Data Analysis, 2nd Ed. 2002. Wiley). Allelotyping and genotyping analyses may be carried out in populations other than those exemplified herein to enhance the predictive power of the prognostic method. These further analyses are executed in view of the exemplified procedures described herein, and may be based upon the same polymorphic variations or additional polymorphic variations.

The nucleic acid sample typically is isolated from a biological sample obtained from a subject. For example, nucleic acid can be isolated from blood, saliva, sputum, urine, cell scrapings, and biopsy tissue. The nucleic acid sample can be isolated from a biological sample using standard techniques, such as the technique described in Example 2. As used herein, the term “subject” refers primarily to humans but also refers to other mammals such as dogs, cats, and ungulates (e.g., cattle, sheep, and swine). Subjects also include avians (e.g., chickens and turkeys), reptiles, and fish (e.g., salmon), as embodiments described herein can be adapted to nucleic acid samples isolated from any of these organisms. The nucleic acid sample may be isolated from the subject and then directly utilized in a method for determining the presence of a polymorphic variant, or alternatively, the sample may be isolated and then stored (e.g., frozen) for a period of time before being subjected to analysis.

The presence or absence of a polymorphic variant is determined using one or both chromosomal complements represented in the nucleic acid sample. Determining the presence or absence of a polymorphic variant in both chromosomal complements represented in a nucleic acid sample from a subject having a copy of each chromosome is useful for determining the zygosity of an individual for the polymorphic variant (i.e., whether the individual is homozygous or heterozygous for the polymorphic variant). Any oligonucleotide-based diagnostic may be utilized to determine whether a sample includes the presence or absence of a polymorphic variant in a sample. For example, primer extension methods, ligase sequence determination methods (e.g., U.S. Pat. Nos. 5,679,524 and 5,952,174, and WO 01/27326), mismatch sequence determination methods (e.g., U.S. Pat. Nos. 5,851,770; 5,958,692; 6,110,684; and 6,183,958), microarray sequence determination methods, restriction fragment length polymorphism (RFLP), single strand conformation polymorphism detection (SSCP) (e.g., U.S. Pat. Nos. 5,891,625 and 6,013,499), PCR-based assays (e.g., TAQMAN® PCR System (Applied Biosystems)), and nucleotide sequencing methods may be used.

Oligonucleotide extension methods typically involve providing a pair of oligonucleotide primers in a polymerase chain reaction (PCR) or in other nucleic acid amplification methods for the purpose of amplifying a region from the nucleic acid sample that comprises the polymorphic variation. One oligonucleotide primer is complementary to a region 3′ of the polymorphism and the other is complementary to a region 5′ of the polymorphism. A PCR primer pair may be used in methods disclosed in U.S. Pat. Nos. 4,683,195; 4,683,202, 4,965,188; 5,656,493; 5,998,143; 6,140,054; WO 01/27327; and WO 01/27329 for example. PCR primer pairs may also be used in any commercially available machines that perform PCR, such as any of the GENEAMP® Systems available from Applied Biosystems. Also, those of ordinary skill in the art will be able to design oligonucleotide primers based upon a nucleotide sequence of SEQ ID NO: 1-17 without undue experimentation using knowledge readily available in the art.

Also provided are extension oligonucleotides that hybridize to the amplified fragment adjacent to the polymorphic variation. As used herein, the term “adjacent” refers to the 3′ end of the extension oligonucleotide being sometimes 1 nucleotide from the 5′ end of the polymorphic site, often 2 or 3, and at times 4, 5, 6, 7, 8, 9, or 10 nucleotides from the 5′ end of the polymorphic site, in the nucleic acid when the extension oligonucleotide is hybridized to the nucleic acid. The extension oligonucleotide then is extended by one or more nucleotides, often 2 or 3 nucleotides, and the number and/or type of nucleotides that are added to the extension oligonucleotide determine whether the polymorphic variant is present. Oligonucleotide extension methods are disclosed, for example, in U.S. Pat. Nos. 4,656,127; 4,851,331; 5,679,524; 5,834,189; 5,876,934; 5,908,755; 5,912,118; 5,976,802; 5,981,186; 6,004,744; 6,013,431; 6,017,702; 6,046,005; 6,087,095; 6,210,891; and WO 01/20039. Oligonucleotide extension methods using mass spectrometry are described, for example, in U.S. Pat. Nos. 5,547,835; 5,605,798; 5,691,141; 5,849,542; 5,869,242; 5,928,906; 6,043,031; and 6,194,144, and a method often utilized is described herein in Example 2.

A microarray can be utilized for determining whether a polymorphic variant is present or absent in a nucleic acid sample. A microarray sometimes includes an oligonucleotides described herein, and methods for making and using oligonucleotide microarrays suitable for prognostic use are disclosed in U.S. Pat. Nos. 5,492,806; 5,525,464; 5,589,330; 5,695,940; 5,849,483; 6,018,041; 6,045,996; 6,136,541; 6,142,681; 6,156,501; 6,197,506; 6,223,127; 6,225,625; 6,229,911; 6,239,273; WO 00/52625; WO 01/25485; and WO 01/29259. The microarray typically comprises a solid support and the oligonucleotides sometimes are linked to the solid support by covalent or non-covalent interactions. The oligonucleotides sometimes are linked to the solid support directly or by a spacer molecule. A microarray sometimes comprise one or more oligonucleotides complementary to a portion of SEQ ID NO: 1-17, or complementary to a variant described herein.

A kit may also be utilized for determining whether a polymorphic variant is present or absent in a nucleic acid sample. A kit often comprises one or more pairs of oligonucleotide primers useful for amplifying a fragment of SEQ ID NO: 1-17 or a substantially identical sequence thereof, where the fragment includes a polymorphic site. The kit sometimes comprises a polymerizing agent, for example, a thermostable nucleic acid polymerase such as one disclosed in U.S. Pat. No. 4,889,818 or 6,077,664. Also, the kit often comprises an elongation oligonucleotide that hybridizes to a NRP1, NID2, ENDO180, CDK180, FPGT, CARK, PCLO or REPS2 nucleic acid in a nucleic acid sample adjacent to the polymorphic site. Where the kit includes an elongation oligonucleotide, it also often comprises chain elongating nucleotides, such as dATP, dTTP, dGTP, dCTP, and dITP, including analogs of dATP, dTTP, dGTP, dCTP and dITP, provided that such analogs are substrates for a thermostable nucleic acid polymerase and can be incorporated into a nucleic acid chain elongated from the extension oligonucleotide. Along with chain elongating nucleotides would be one or more chain terminating nucleotides such as ddATP, ddTTP, ddGTP, ddCTP, and the like. In an embodiment, the kit comprises one or more oligonucleotide primer pairs, a polymerizing agent, chain elongating nucleotides, at least one elongation oligonucleotide, and one or more chain terminating nucleotides. Kits optionally include buffers, vials, microtitre plates, and instructions for use. NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 directed hits may be utilized to prognose or diagnose melanoma for a significant fraction of melanoma occurrences, such as in 50% or more melanoma occurrences, or sometimes 60% or more, 70% or more, 80% or more, 90% or more, or 95% or more melanoma occurrences.

Using a polymorphism detection technology (e.g., a technique described above or below in Example 2), mutations and polymorphisms in or around the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 locus may be detected in melanocytic lesions, which include nevi, radial growth phase (RGP) melanomas, vertical growth phase (VGP) melanomas, and melanoma metastases. The mutations can be detected within 50 kilobases (kb), 40 kb, 30 kb, 20 kb, 15, kb, 10 kb, 5 kb, 4 kb, 3 kb, 2 kb, or 1 kb from the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 open reading frame initiation or termination site. Therefore, provided herein are methods for genotyping NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mutations in melanocytic lesions and metastases (e.g., described in Example 2). Mutations in or around the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 loci present in later stage melanomas, such as VGP melanomas and melanoma metastases, are indicative of melanomas particularly likely to continue to progress and/or metastasize (e.g., from RGP to VGP melanoma or melanoma metastases), i.e., aggressive melanomas. Thus, provided herein are methods for identifying subjects at risk of a progressive or aggressive melanoma by determining the presence or absence of one or more NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mutations in the DNA sample of a subject that exist in melanocytic lesions and/or metastases. Identifying the presence of one or more of these mutations is useful for identifying subjects in need of aggressive treatments of melanoma, and once identified using such methods, a subject often is given information concerning preventions and treatments of the disease, and sometimes is treated with an aggressive melanoma treatment method (e.g., surgery or administration of drugs), as described in more detail hereafter.

Determining the presence of a polymorphic variant, or a combination of two or more polymorphic variants, in a nucleic acid set forth in SEQ ID NO: 1-17, or SEQ ID NO: 1-7, of the sample often is indicative of a predisposition to melanoma. In certain embodiments, nucleic acid variants of other loci, such as the BRAF locus described in U.S. application Ser. No. 10/661,966 filed Sep. 11, 2003 for example, are detected in combination with one or more nucleic acid variants in the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 loci.

The following variants are associated with an increased risk of melanoma: a thymine at the chromosome position indicated by rs1360457, an adenine at the chromosome position indicated by rs753050, a guanine at the chromosome position indicated by rs729647, a thymine at the chromosome position indicated by rs3742536, a guanine at position 32137 in SEQ ID NO: 1, a thymine at position 12008 in SEQ ID NO: 1, a cytosine at position 32720 in SEQ ID NO: 1, an adenine at position 43721 in SEQ ID NO: 1, a guanine at position 44339 in SEQ ID NO: 1, a thymine at position 45640 in SEQ ID NO: 1, an adenine at position 48768 in SEQ ID NO: 1, a guanine at position 74247 in SEQ ID NO: 1, a thymine at position 75828 in SEQ ID NO: 1, an adenine at position 76381 in SEQ ID NO: 1, and a cytosine at position 84909. An individual identified as being at risk of melanoma may be heterozygous or homozygous with respect to the allele associated with melanoma. A subject homozygous for an allele associated with an increased risk of melanoma (e.g., a thymine at position 45640 in SEQ ID NO: 1) is at a comparatively high risk of melanoma, a subject heterozygous for an allele associated with an increased risk of melanoma is at a comparatively intermediate risk of melanoma, and a subject homozygous for an allele associated with a decreased risk of melanoma (e.g., a cytosine at position 45640 in SEQ ID NO: 1, see Examples section below) is at a comparatively lower risk of melanoma. A genotype may be assessed for a complementary strand, such that the complementary nucleotide at a particular position is detected (e.g., if a thymine or cytosine is detected at position 45640 in SEQ ID NO: 1, the complementary strand would yield an adenine or guanine, respectively, where the adenine is associated with increased risk of melanoma).

Also featured are methods for determining risk of melanoma and/or identifying a subject at risk of melanoma by contacting a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or protein from a subject with an antibody that specifically binds to an epitope associated with increased risk of melanoma in the polypeptide. In an embodiment, the antibody specifically binds to an epitope that comprises a serine at amino acid position 656 in a NID2 polypeptide.

Applications of Genomic Information to Pharmacogenomics

Pharmacogenomics is a discipline that involves tailoring a treatment for a subject according to the subject's genotype as a particular treatment regimen may exert a differential effect depending upon the subject's genotype. Based upon the outcome of a prognostic test described herein, a clinician or physician may target pertinent information and preventative or therapeutic treatments to a subject who would be benefited by the information or treatment and avoid directing such information and treatments to a subject who would not be benefited (e.g., the treatment has no therapeutic effect and/or the subject experiences adverse side effects).

For example, where a candidate therapeutic exhibits a significant interaction with a major allele and a comparatively weak interaction with a minor allele (e.g., an order of magnitude or greater difference in the interaction), such a therapeutic typically would not be administered to a subject genotyped as being homozygous for the minor allele, and sometimes not administered to a subject genotyped as being heterozygous for the minor allele. In another example, where a candidate therapeutic is not significantly toxic when administered to subjects who are homozygous for a major allele but is comparatively toxic when administered to subjects heterozygous or homozygous for a minor allele, the candidate therapeutic is not typically administered to subjects who are genotyped as being heterozygous or homozygous with respect to the minor allele.

The prognostic methods described herein are applicable to general pharmacogenomic approaches towards addressing melanoma. For example, a nucleic acid sample from an individual may be subjected to a prognostic test described herein. Where one or more polymorphic variations associated with increased risk of melanoma are identified in a subject, one or more melanoma treatments or prophylactic regimens may be prescribed to that subject. Subjects genotyped as having one or more of the alleles described herein that are associated with increased risk of melanoma often are prescribed a prophylactic regimen designed to minimize the occurrence of melanoma. An example of a prophylactic regimen often prescribed is directed towards minimizing ultraviolet (UV) light exposure. Such a regimen may include, for example, prescription of a lotion applied to the skin that minimizes UV penetration and/or counseling individuals of other practices for reducing UV exposure, such as by wearing protective clothing and minimizing sun exposure.

In certain embodiments, a treatment regimen is specifically prescribed and/or administered to individuals who will most benefit from it based upon their risk of developing melanoma assessed by the prognostic methods described herein. Thus, provided are methods for identifying a subject predisposed to melanoma and then prescribing a therapeutic or preventative regimen to individuals identified as having a predisposition. Thus, certain embodiments are directed to a method for reducing melanoma in a subject, which comprises: detecting the presence or absence of a polymorphic variant associated with melanoma in a nucleotide sequence of a nucleic acid sample from a subject, where the nucleotide sequence comprises a polynucleotide sequence selected from the group consisting of: (a) a nucleotide sequence set forth in SEQ ID NO: 1-17; (b) a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-17; (c) a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-17 or a nucleotide sequence about 90% or more identical to the nucleotide sequence in SEQ ID NO: 1-17; and (d) a fragment of a polynucleotide sequence of (a), (b), or (c); and prescribing or administering a treatment regimen to a subject from whom the sample originated where the presence of a polymorphic variation associated with melanoma is detected in the nucleotide sequence. In these methods, predisposition results may be utilized in combination with other test results to diagnose melanoma.

The treatment sometimes is preventative (e.g., is prescribed or administered to reduce the probability that a melanoma associated condition arises or progresses), sometimes is therapeutic, and sometimes delays, alleviates or halts the progression of a melanoma associated condition. Any known preventative or therapeutic treatment for alleviating or preventing the occurrence of a melanoma associated disorder is prescribed and/or administered. For example, the treatment sometimes is or includes a drug that reduces melanoma, including, for example, cisplatin, carmustine (BCNU), vinblastine, vincristine, and bleomycin, and/or a molecule that interacts with a nucleic acid or polypeptide described hereafter. In another example, the melanoma treatment is surgery. Surgery to remove (excise) a melanoma is the standard treatment for this disease. It is necessary to remove not only the tumor but also some normal tissue around it in order to minimize the chance that any cancer will be left in the area. It is common for lymph nodes near the tumor to be removed during surgery because cancer can spread through the lymphatic system. Surgery is generally not effective in controlling melanoma that is known to have spread to other parts of the body. In such cases, doctors may use other methods of treatment, such as chemotherapy, biological therapy, radiation therapy, or a combination of these methods.

As therapeutic approaches for melanoma continue to evolve and improve, the goal of treatments for melanoma related disorders is to intervene even before clinical signs (e.g., identification of irregular nevi based on A—asymmetry, B—border irregularity, C—color variation, D—diameter of >6 mm as described by Friedman R J, et al. in CA Cancer J. Clin. 1985 May-June; 35(3): 130-51) first manifest. Thus, genetic markers associated with susceptibility to melanoma prove useful for early diagnosis, prevention and treatment of melanoma.

As melanoma preventative and treatment information can be specifically targeted to subjects in need thereof (e.g., those at risk of developing melanoma or those that have early signs of melanoma), provided herein is a method for preventing or reducing the risk of developing melanoma in a subject, which comprises: (a) detecting the presence or absence of a polymorphic variation associated with melanoma at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) identifying a subject with a predisposition to melanoma, whereby the presence of the polymorphic variation is indicative of a predisposition to melanoma in the subject; and (c) if such a predisposition is identified, providing the subject with information about methods or products to prevent or reduce melanoma or to delay the onset of melanoma. Also provided is a method of targeting information or advertising to a subpopulation of a human population based on the subpopulation being genetically predisposed to a disease or condition, which comprises: (a) detecting the presence or absence of a polymorphic variation associated with melanoma at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) identifying the subpopulation of subjects in which the polymorphic variation is associated with melanoma; and (c) providing information only to the subpopulation of subjects about a particular product which may be obtained and consumed or applied by the subject to help prevent or delay onset of the disease or condition.

Pharmacogenomics methods also may be used to analyze and predict a response to a melanoma treatment or a drug. For example, if pharmacogenomics analysis indicates a likelihood that an individual will respond positively to a melanoma treatment with a particular drug, the drug may be administered to the individual. Conversely, if the analysis indicates that an individual is likely to respond negatively to treatment with a particular drug, an alternative course of treatment may be prescribed. A negative response may be defined as either the absence of an efficacious response or the presence of toxic side effects. The response to a therapeutic treatment can be predicted in a background study in which subjects in any of the following populations are genotyped: a population that responds favorably to a treatment regimen, a population that does not respond significantly to a treatment regimen, and a population that responds adversely to a treatment regiment (e.g., exhibits one or more side effects). These populations are provided as examples and other populations and subpopulations may be analyzed. Based upon the results of these analyses, a subject is genotyped to predict whether he or she will respond favorably to a treatment regimen, not respond significantly to a treatment regimen, or respond adversely to a treatment regimen.

The tests described herein also are applicable to clinical drug trials. One or more polymorphic variants indicative of response to an agent for treating melanoma or to side effects to an agent for treating melanoma may be identified using the methods described herein. Thereafter, potential participants in clinical trials of such an agent may be screened to identify those individuals most likely to respond favorably to the drug and exclude those likely to experience side effects. In that way, the effectiveness of drug treatment may be measured in individuals who respond positively to the drug, without lowering the measurement as a result of the inclusion of individuals who are unlikely to respond positively in the study and without risking undesirable safety problems.

Thus, another embodiment is a method of selecting an individual for inclusion in a clinical trial of a treatment or drug comprising the steps of: (a) obtaining a nucleic acid sample from an individual; (b) determining the identity of a polymorphic variation which is associated with a positive response to the treatment or the drug, or at least one polymorphic variation which is associated with a negative response to the treatment or the drug in the nucleic acid sample, and (c) including the individual in the clinical trial if the nucleic acid sample contains said polymorphic variation associated with a positive response to the treatment or the drug or if the nucleic acid sample lacks said polymorphic variation associated with a negative response to the treatment or the drug. In addition, the methods for selecting an individual for inclusion in a clinical trial of a treatment or drug encompass methods with any further limitation described in this disclosure, or those following, specified alone or in any combination. The polymorphic variation may be in a sequence selected individually or in any combination from the group consisting of (i) a polynucleotide sequence set forth in SEQ ID NO: 1-17; (ii) a polynucleotide sequence that is 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-17; (iii) a polynucleotide sequence that encodes a polypeptide having an amino acid sequence identical to or 90% or more identical to an amino acid sequence encoded by a nucleotide sequence of SEQ ID NO: 1-17; and (iv) a fragment of a polynucleotide sequence of (i), (ii), or (iii) comprising the polymorphic site. The including step (c) optionally comprises administering the drug or the treatment to the individual if the nucleic acid sample contains the polymorphic variation associated with a positive response to the treatment or the drug and the nucleic acid sample lacks said biallelic marker associated with a negative response to the treatment or the drug.

Also provided herein is a method of partnering between a diagnostic/prognostic testing provider and a provider of a consumable product, which comprises: (a) the diagnostic/prognostic testing provider detects the presence or absence of a polymorphic variation associated with melanoma at a polymorphic site in a nucleotide sequence in a nucleic acid sample from a subject; (b) the diagnostic/prognostic testing provider identifies the subpopulation of subjects in which the polymorphic variation is associated with melanoma; (c) the diagnostic/prognostic testing provider forwards information to the subpopulation of subjects about a particular product which may be obtained and consumed or applied by the subject to help prevent or delay onset of the disease or condition; and (d) the provider of a consumable product forwards to the diagnostic test provider a fee every time the diagnostic/prognostic test provider forwards information to the subject as set forth in step (c) above.

Compositions Comprising a NRP1. NID2. ENDO180. CDK10. FPGT. CARK. PCLO or REPS2 Directed Molecule

Featured herein is a composition comprising a melanoma cell and one or more NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 directed molecules. NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 directed molecules include, but are not limited to, a compound that binds to a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid or polypeptide; an RNAi or siRNA molecule having a strand complementary to a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 DNA sequence; an antisense nucleic acid complementary to an RNA encoded by a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 DNA sequence; a nucleic acid complementary to a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 RNA, cDNA or gDNA nucleotide sequence, sometimes linked to a solid support or an array; a ribozyme that hybridizes to a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence; an NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, protein or fragment thereof, or a nucleic acid that encodes the foregoing; a nucleic acid aptamer that specifically binds a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, protein, nucleic acid or variant thereof; and an antibody or fragment thereof that specifically binds to a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, protein, nucleic acid or variant thereof. Compositions comprising an antibody often include an adjuvant known in the art. The melanoma cell may be in a group of melanoma cells and/or other types of cells cultured in vitro or in a tissue having melanoma cells (e.g., a melanocytic lesion) maintained in vitro or present in an animal in vivo (e.g., a rat, mouse, ape or human). In certain embodiments, a composition comprises a component from a melanoma cell or from a subject having a melanoma cell instead of the melanoma cell or in addition to the melanoma cell, where the component sometimes is a nucleic acid molecule (e.g., genomic DNA), a protein mixture or isolated protein, for example. The aforementioned compositions have utility in diagnostic, prognostic and pharmacogenomic methods described previously and in melanoma therapeutics described hereafter. Certain NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 directed molecules are described in greater detail below.

Compounds

Compounds can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; peptoid libraries (libraries of molecules having the functionalities of peptides, but with a novel, non-peptide backbone which are resistant to enzymatic degradation but which nevertheless remain bioactive (see, e.g., Zuckermann et al., J. Med. Chem. 37: 2678-85 (1994)); spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; “one-bead one-compound” library methods; and synthetic library methods using affinity chromatography selection. Biological library and peptoid library approaches are typically limited to peptide libraries, while the other approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam, Anticancer Drug Des. 12: 145, (1997)). Examples of methods for synthesizing molecular libraries are described, for example, in DeWitt et al., Proc. Natl. Acad. Sci. USA. 90: 6909 (1993); Erb et al., Proc. Natl. Acad. Sci. USA 91: 11422 (1994); Zuckermann et al., J. Med. Chem. 37: 2678 (1994); Cho et al., Science 261: 1303 (1993); Carrell et al., Angew. Chem. Int. Ed. Engl. 33: 2059 (1994); Carell et al., Angew. Chem. Int. Ed. Engl. 33: 2061 (1994); and in Gallop et al., J. Med. Chem. 37: 1233 (1994).

Libraries of compounds may be presented in solution (e.g., Houghten, Biotechniques 13: 412421 (1992)), or on beads (Lam, Nature 354: 82-84 (1991)), chips (Fodor, Nature 364: 555-556 (1993)), bacteria or spores (Ladner, U.S. Pat. No. 5,223,409), plasmids (Cull et al., Proc. Natl. Acad. Sci. USA 89: 1865-1869 (1992)) or on phage (Scott and Smith, Science 249: 386-390 (1990); Devlin, Science 249: 404-406 (1990); Cwirla et al., Proc. Natl. Acad. Sci. 87: 6378-6382 (1990); Felici, J. Mol. Biol. 222: 301-310 (1991); Ladner supra.).

A compound may alter expression or activity of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides and may be a small molecule. Small molecules include, but are not limited to, peptides, peptidomimetics (e.g., peptoids), amino acids, amino acid analogs, polynucleotides, polynucleotide analogs, nucleotides, nucleotide analogs, organic or inorganic compounds (i.e., including heteroorganic and organometallic compounds) having a molecular weight less than about 10,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 5,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 1,000 grams per mole, organic or inorganic compounds having a molecular weight less than about 500 grams per mole, and salts, esters, and other pharmaceutically acceptable forms of such compounds.

Antisense Nucleic Acid Molecules, Ribozymes, RNAi, siRNA and Modified NRP1, NID2. ENDO180. CDK10. FPGT, CARK, PCLO or REPS2 Nucleic Acid Molecules

An “antisense” nucleic acid refers to a nucleotide sequence complementary to a “sense” nucleic acid encoding a polypeptide, e.g., complementary to the coding strand of a double-stranded cDNA molecule or complementary to an mRNA sequence. The antisense nucleic acid can be complementary to an entire NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 coding strand, or to only a portion thereof (e.g., coding regions of human NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 in SEQ ID NO: 1-17). In another embodiment, the antisense nucleic acid molecule is antisense to a “noncoding region” of the coding strand of a nucleotide sequence encoding NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 (e.g., 5′ and 3′ untranslated regions).

An antisense nucleic acid can be designed such that it is complementary to the entire coding region of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA, and often the antisense nucleic acid is an oligonucleotide antisense to only a portion of a coding or noncoding region of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA, e.g., between the −10 and +10 regions of the target gene nucleotide sequence of interest. An antisense oligonucleotide can be, for example, about 7, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, or more nucleotides in length. The antisense nucleic acids, which include the ribozymes described hereafter, can be designed to target NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid or NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid variants. Among the variants, minor alleles and major alleles can be targeted, and those associated with a higher risk of melanoma are often designed, tested, and administered to subjects.

An antisense nucleic acid can be constructed using chemical synthesis and enzymatic ligation reactions using standard procedures. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. Antisense nucleic acid also can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).

When utilized as therapeutics, antisense nucleic acids typically are administered to a subject (e.g., by direct injection at a tissue site) or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide and thereby inhibit expression of the polypeptide, for example, by inhibiting transcription and/or translation. Alternatively, antisense nucleic acid molecules can be modified to target selected cells and then are administered systemically. For systemic administration, antisense molecules can be modified such that they specifically bind to receptors or antigens expressed on a selected cell surface, for example, by linking antisense nucleic acid molecules to peptides or antibodies which bind to cell surface receptors or antigens. Antisense nucleic acid molecules can also be delivered to cells using the vectors described herein. Sufficient intracellular concentrations of antisense molecules are achieved by incorporating a strong promoter, such as a pol II or pol III promoter, in the vector construct.

Antisense nucleic acid molecules sometimes are α-anomeric nucleic acid molecules. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual β-units, the strands run parallel to each other (Gaultier et al., Nucleic Acids. Res. 15: 6625-6641 (1987)). Antisense nucleic acid molecules can also comprise a 2′—O— methylribonucleotide (Inoue et al., Nucleic Acids Res. 15: 6131-6148 (1987)) or a chimeric RNA-DNA analogue (Inoue et al., FEBS Lett. 215: 327-330 (1987)). Antisense nucleic acids sometimes are composed of DNA or PNA or any other nucleic acid derivatives described previously.

In another embodiment, an antisense nucleic acid is a ribozyme. A ribozyme having specificity for a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 encoding nucleic acid can include one or more sequences complementary to the nucleotide sequence of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 DNA sequence disclosed herein (e.g., SEQ ID NO: 1-17), and a sequence having a known catalytic region responsible for mRNA cleavage (see e.g., U.S. Pat. No. 5,093,246 or Haselhoff and Gerlach, Nature 334: 585-591 (1988)). For example, a derivative of a Tetrahymena L-19 IVS RNA is sometimes utilized in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 encoding mRNA (see e.g., Cech et al. U.S. Pat. No. 4,987,071; and Cech et al. U.S. Pat. No. 5,116,742). Also, NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules (see e.g., Bartel & Szostak, Science 261: 1411-1418 (1993)).

NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 directed molecules include in certain embodiments nucleic acids that can form triple helix structures with a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence, especially one that includes a regulatory region that controls NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 expression. NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 (e.g., NRP1, NID2, ENDO80, CDK10, FPGT, CARK, PCLO or REPS2 promoter and/or enhancers) to form triple helical structures that prevent transcription of the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 gene in target cells (see e.g., Helene, Anticancer Drug Des. 6(6): 569-84 (1991); Helene et al., Ann. N.Y. Acad. Sci. 660: 27-36 (1992); and Maher, Bioassays 14(12): 807-15 (1992). Potential sequences that can be targeted for triple helix formation can be increased by creating a so-called “switchback” nucleic acid molecule. Switchback molecules are synthesized in an alternating 5′-3′,3′-5′ manner, such that they base pair with first one strand of a duplex and then the other, eliminating the necessity for a sizeable stretch of either purines or pyrimidines to be present on one strand of a duplex.

NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 directed molecules include RNAi and siRNA nucleic acids. Gene expression may be inhibited by the introduction of double-stranded RNA (dsRNA), which induces potent and specific gene silencing, a phenomenon called RNA interference or RNAi. See, e.g., Fire et al., U.S. Pat. No. 6,506,559; Tuschl et al. PCT International Publication No. WO 01/75164; Kay et al. PCT International Publication No. WO 03/010180A1; or Bosher J M, Labouesse, Nat Cell Biol 2000 February; 2(2): E31-6. This process has been improved by decreasing the size of the double-stranded RNA to 20-24 base pairs (to create small-interfering RNAs or siRNAs) that “switched off” genes in mammalian cells without initiating an acute phase response, i.e., a host defense mechanism that often results in cell death (see, e.g., Caplen et al. Proc Natl Acad Sci USA. 2001 Aug. 14; 98(17): 9742-7 and Elbashir et al. Methods 2002 February; 26(2): 199-213). There is increasing evidence of post-transcriptional gene silencing by RNA interference (RNAi) for inhibiting targeted expression in mammalian cells at the mRNA level, in human cells. There is additional evidence of effective methods for inhibiting the proliferation and migration of tumor cells in human patients, and for inhibiting metastatic cancer development (see, e.g., U.S. patent application No. U.S.2001000993183; Caplen et al. Proc Natl Acad Sci USA; and Abderrahmani et al. Mol Cell Biol 2001 November 21(21): 7256-67).

An “siRNA” or “RNAi” refers to a nucleic acid that forms a double stranded RNA and has the ability to reduce or inhibit expression of a gene or target gene when the siRNA is delivered to or expressed in the same cell as the gene or target gene. “siRNA” refers to short double-stranded RNA formed by the complementary strands. Complementary portions of the siRNA that hybridize to form the double stranded molecule often have substantial or complete identity to the target molecule sequence. In one embodiment, an siRNA refers to a nucleic acid that has substantial or complete identity to a target gene and forms a double stranded siRNA, such as a nucleotide sequence set forth in SEQ ID NO: 1-17, for example.

When designing the siRNA molecules, the targeted region often is selected from a given DNA sequence beginning 50 to 100 nucleotides downstream of the start codon. See, e.g., Elbashir et al,. Methods 26: 199-213 (2002). Initially, 5′ or 3′ UTRs and regions nearby the start codon were avoided assuming that UTR-binding proteins and/or translation initiation complexes may interfere with binding of the siRNP or RISC endonuclease complex. Sometimes regions of the target 23 nucleotides in length conforming to the sequence motif AA(N19)TT (N, an nucleotide), and regions with approximately 30% to 70% G/C-content (often about 50% G/C-content) often are selected. If no suitable sequences are found, the search often is extended using the motif NA(N21). The sequence of the sense siRNA sometimes corresponds to (N19) TT or N21 (position 3 to 23 of the 23-nt motif), respectively. In the latter case, the 3′ end of the sense siRNA often is converted to TT. The rationale for this sequence conversion is to generate a symmetric duplex with respect to the sequence composition of the sense and antisense 3′ overhangs. The antisense siRNA is synthesized as the complement to position 1 to 21 of the 23-nt motif. Because position 1 of the 23-nt motif is not recognized sequence-specifically by the antisense siRNA, the 3′-most nucleotide residue of the antisense siRNA can be chosen deliberately. However, the penultimate nucleotide of the antisense siRNA (complementary to position 2 of the 23-nt motif) often is complementary to the targeted sequence. For simplifying chemical synthesis, TT often is utilized. siRNAs corresponding to the target motif NAR(N 17)YNN, where R is purine (A,G) and Y is pyrimidine (C,U), often are selected. Respective 21 nucleotide sense and antisense siRNAs often begin with a purine nucleotide and can also be expressed from pol III expression vectors without a change in targeting site. Expression of RNAs from pol III promoters often is efficient when the first transcribed nucleotide is a purine.

The sequence of the siRNA can correspond to the full length target gene, or a subsequence thereof. Often, the siRNA is about 15 to about 50 nucleotides in length (e.g., each complementary sequence of the double stranded siRNA is 15-50 nucleotides in length, and the double stranded siRNA is about 15-50 base pairs in length, sometimes about 20-30 nucleotides in length or about 20-25 nucleotides in length, e.g., 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30 nucleotides in length. The siRNA sometimes is about 21 nucleotides in length. Methods of using siRNA are well known in the art, and specific siRNA molecules may be purchased from a number of companies including Dharmacon Research, Inc.

Antisense, ribozyme, RNAi and siRNA nucleic acids can be altered to form modified NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid molecules. The nucleic acids can be altered at base moieties, sugar moieties or phosphate backbone moieties to improve stability, hybridization, or solubility of the molecule. For example, the deoxyribose phosphate backbone of nucleic acid molecules can be modified to generate peptide nucleic acids (see Hyrup et al., Bioorganic & Medicinal Chemistry 4 (1): 5-23 (1996)). As used herein, the terms “peptide nucleic acid” or “PNA” refers to a nucleic acid mimic such as a DNA mimic, in which the deoxyribose phosphate backbone is replaced by a pseudopeptide backbone and only the four natural nucleobases are retained. The neutral backbone of a PNA can allow for specific hybridization to DNA and RNA under conditions of low ionic strength. Synthesis of PNA oligomers can be performed using standard solid phase peptide synthesis protocols as described, for example, in Hyrup et al., (1996) supra and Perry-O'Keefe et al., Proc. Natl. Acad. Sci. 93: 14670-675 (1996).

PNAs of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acids can be used in prognostic, diagnostic, and therapeutic applications. For example, PNAs can be used as antisense or antigene agents for sequence-specific modulation of gene expression by, for example, inducing transcription or translation arrest or inhibiting replication. PNAs of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid molecules can also be used in the analysis of single base pair mutations in a gene, (e.g., by PNA-directed PCR clamping); as “artificial restriction enzymes” when used in combination with other enzymes, (e.g., S1 nucleases (Hyrup (1996) supra)); or as probes or primers for DNA sequencing or hybridization (Hyrup et al., (1996) supra; Perry-O'Keefe supra).

In other embodiments, oligonucleotides may include other appended groups such as peptides (e.g., for targeting host cell receptors in vivo), or agents facilitating transport across cell membranes (see e.g., Letsinger et al., Proc. Natl. Acad. Sci. USA 86: 6553-6556 (1989); Lemaitre et al., Proc. Natl. Acad. Sci. USA 84: 648-652 (1987); PCT Publication No. WO88/09810) or the blood-brain barrier (see, e.g., PCT Publication No. WO89/10134). In addition, oligonucleotides can be modified with hybridization-triggered cleavage agents (See, e.g., Krol et al., Bio-Techniques 6: 958-976 (1988)) or intercalating agents. (See, e.g., Zon, Pharm. Res. 5: 539-549 (1988)). To this end, the oligonucleotide may be conjugated to another molecule, (e.g., a peptide, hybridization triggered cross-linking agent, transport agent, or hybridization-triggered cleavage agent).

Also included herein are molecular beacon oligonucleotide primer and probe molecules having one or more regions complementary to a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid, two complementary regions one having a fluorophore and one a quencher such that the molecular beacon is useful for quantifying the presence of the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid in a sample. Molecular beacon nucleic acids are described, for example, in Lizardi et al., U.S. Pat. No. 5,854,033; Nazarenko et al., U.S. Pat. No. 5,866,336, and Livak et al., U.S. Pat. No. 5,876,930.

Anti-NRP1. NID2. ENDO180. CDK10, FPGT. CARK. PCLO or REPS2 Antibodies

The term “antibody” as used herein refers to an immunoglobulin molecule or immunologically active portion thereof, i.e., an antigen-binding portion. Examples of immunologically active portions of immunoglobulin molecules include F(ab) and F(ab′)₂ fragments which can be generated by treating the antibody with an enzyme such as pepsin. An antibody sometimes is a polyclonal, monoclonal, recombinant (e.g., a chimeric or humanized), fully human, non-human (e.g., murine), or a single chain antibody. An antibody may have effector function and can fix complement, and is sometimes coupled to a toxin or imaging agent.

A full-length NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or antigenic peptide fragment can be used as an immunogen or can be used to identify anti-NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antibodies made with other immunogens, e.g., cells, membrane preparations, and the like. An antigenic peptide of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 often includes at least 8 amino acid residues of the amino acid sequences set forth in SEQ ID NO: 18-27 and encompasses an epitope of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2. Antigenic peptides sometimes include 10 or more amino acids, 15 or more amino acids, 20 or more amino acids, or 30 or more amino acids. Hydrophilic and hydrophobic fragments of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides sometimes are used as immunogens.

Epitopes encompassed by the antigenic peptide are regions of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 located on the surface of the polypeptide (e.g., hydrophilic regions) as well as regions with high antigenicity. For example, an Emini surface probability analysis of the human NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide sequence can be used to indicate the regions that have a particularly high probability of being localized to the surface of the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide and are thus likely to constitute surface residues useful for targeting antibody production. The antibody may bind an epitope on any domain or region on NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides described herein.

Also, chimeric, humanized, and completely human antibodies are useful for applications which include repeated administration to subjects. Chimeric and humanized monoclonal antibodies, comprising both human and non-human portions, can be made using standard recombinant DNA techniques. Such chimeric and humanized monoclonal antibodies can be produced by recombinant DNA techniques known in the art, for example using methods described in Robinson et al International Application No. PCT/US86/02269; Akira, et al European Patent Application 184,187; Taniguchi, M., European Patent Application 171,496; Morrison et al European Patent Application 173,494; Neuberger et al PCT International Publication No. WO 86/01533; Cabilly et al U.S. Pat. No. 4,816,567; Cabilly et al European Patent Application 125,023; Better et al., Science 240: 1041-1043 (1988); Liu et al., Proc. Natl. Acad. Sci. USA 84: 3439-3443 (1987); Liu et al., J. Immunol. 139: 3521-3526 (1987); Sun et al., Proc. Natl. Acad. Sci. USA 84: 214-218 (1987); Nishimura et al., Canc. Res. 47: 999-1005 (1987); Wood et al., Nature 314: 446-449 (1985); and Shaw et al., J. Natl. Cancer Inst. 80: 1553-1559 (1988); Morrison, S. L., Science 229: 1202-1207 (1985); Oi et al., BioTechniques 4: 214 (1986); Winter U.S. Pat. No. 5,225,539; Jones et al., Nature 321: 552-525 (1986); Verhoeyan et al., Science 239: 1534; and Beidler et al., J. Immunol. 141: 4053-4060 (1988).

Completely human antibodies are particularly desirable for therapeutic treatment of human patients. Such antibodies can be produced using transgenic mice that are incapable of expressing endogenous immunoglobulin heavy and light chains genes, but which can express human heavy and light chain genes. See, for example, Lonberg and Huszar, Int. Rev. Immunol. 13: 65-93 (1995); and U.S. Pat. Nos. 5,625,126; 5,633,425; 5,569,825; 5,661,016; and 5,545,806. In addition, companies such as Abgenix, Inc. (Fremont, Calif.) and Medarex, Inc. (Princeton, N.J.), can be engaged to provide human antibodies directed against a selected antigen using technology similar to that described above. Completely human antibodies that recognize a selected epitope also can be generated using a technique referred to as “guided selection.” In this approach a selected non-human monoclonal antibody (e.g., a murine antibody) is used to guide the selection of a completely human antibody recognizing the same epitope. This technology is described for example by Jespers et al., Bio/Technology 12: 899-903 (1994).

An anti-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antibody can be a single chain antibody. A single chain antibody (scFV) can be engineered (see, e.g., Colcher et al., Ann. NY Acad. Sci. 880: 263-80 (1999); and Reiter, Clin. Cancer Res. 2: 245-52 (1996)). Single chain antibodies can be dimerized or multimerized to generate multivalent antibodies having specificities for different epitopes of the same target NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide.

Antibodies also may be selected or modified so that they exhibit reduced or no ability to bind an Fc receptor. For example, an antibody may be an isotype or subtype, fragment or other mutant, which does not support binding to an Fc receptor (e.g., it has a mutagenized or deleted Fc receptor binding region).

Also, an antibody (or fragment thereof) may be conjugated to a therapeutic moiety such as a cytotoxin, a therapeutic agent or a radioactive metal ion. A cytotoxin or cytotoxic agent includes any agent that is detrimental to cells. Examples include taxol, cytochalasin B, gramicidin D, ethidium bromide, emetine, mitomycin, etoposide, tenoposide, vincristine, vinblastine, colchicin, doxorubicin, daunorubicin, dihydroxy anthracin dione, mitoxantrone, mithramycin, actinomycin D, 1-dehydrotestosterone, glucocorticoids, procaine, tetracaine, lidocaine, propranolol, and puromycin and analogs or homologs thereof. Therapeutic agents include, but are not limited to, antimetabolites (e.g., methotrexate, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-fluorouracil decarbazine), alkylating agents (e.g., mechlorethamine, thiotepa chlorambucil, melphalan, carmustine (BCNU) and lomustine (CCNU), cyclophosphamide, busulfan, dibromomannitol, streptozotocin, mitomycin C, and cis-dichlorodiamine platinum (II) (DDP) cisplatin), anthracyclines (e.g., daunorubicin (formerly daunomycin) and doxorubicin), antibiotics (e.g., dactinomycin (formerly actinomycin), bleomycin, mithramycin, and anthramycin (AMC)), and anti-mitotic agents (e.g., vincristine and vinblastine).

Antibody conjugates can be used for modifying a given biological response. For example, the drug moiety may be a protein or polypeptide possessing a desired biological activity. Such proteins may include, for example, a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin; a polypeptide such as tumor necrosis factor, gamma-interferon, alpha-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator; or, biological response modifiers such as, for example, lymphokines, interleukin-1 (“IL-1”), interleukin-2 (“IL-2”), interleukin-6 (“IL-6”), granulocyte macrophage colony stimulating factor (“GM-CSF”), granulocyte colony stimulating factor (“G-CSF”), or other growth factors. Also, an antibody can be conjugated to a second antibody to form an antibody heteroconjugate as described by Segal in U.S. Pat. No. 4,676,980, for example.

An anti-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antibody (e.g., monoclonal antibody) can be used to isolate NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides by standard techniques, such as affinity chromatography or immunoprecipitation. Moreover, an anti-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antibody can be used to detect a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide (e.g., in a cellular lysate or cell supernatant) in order to evaluate the abundance and pattern of expression of the polypeptide. Anti-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antibodies can be used diagnostically to monitor polypeptide levels in tissue as part of a clinical testing procedure, e.g., to determine the efficacy of a given treatment regimen. Detection can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance (i.e., antibody labeling). Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, 3-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include ¹²⁵I, ¹³¹I, ³⁵S or ³H. Also, an anti-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antibody can be utilized as a test molecule for determining whether it can treat melanoma, and as a therapeutic for administration to a subject for treating melanoma.

An antibody can be made by immunizing with a purified NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antigen, or a fragment thereof, e.g., a fragment described herein, a membrane associated antigen, tissues, e.g., crude tissue preparations, whole cells, preferably living cells, lysed cells, or cell fractions.

Included herein are antibodies which bind only a native NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, only denatured or otherwise non-native NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, or which bind both, as well as those having linear or conformational epitopes. Conformational epitopes sometimes can be identified by selecting antibodies that bind to native but not denatured NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. Also featured are antibodies that specifically bind to a NRP1, NID2, ENDO180, CDK10, FPGT, CARK PCLO or REPS2 protein or polypeptide variant associated with melanoma. For example, the antibody sometimes specifically binds to an epitope that comprises a serine at amino acid position 656 in a NID2 protein, polypeptide or peptide.

Screening Assays

Featured herein are methods for identifying a candidate therapeutic for treating melanoma and detecting occurrence of melanoma. The methods comprise contacting a test molecule with a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid, substantially identical nucleic acid, polypeptide, substantially identical polypeptide, or fragment of the foregoing in a system. The nucleic acid often is a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleotide sequence represented by SEQ ID NO: 1-17, respectively; sometimes is a nucleotide sequence substantially identical to the nucleotide sequence of SEQ ID NO: 1-17 or sometimes a fragment thereof; and the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or fragment thereof is a polypeptide encoded by any of these nucleic acids. The method also comprises determining the presence or absence of an interaction between the test molecule and the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid or polypeptide, where the presence of an interaction between the test molecule and the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid or polypeptide identifies the test molecule as a candidate melanoma therapeutic.

As used herein, the term “test molecule” and “candidate therapeutic” refers to modulators of regulation of transcription and translation of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acids and modulations of expression and activity of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides. The term “modulator” as used herein refers to a molecule which agonizes or antagonizes NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 DNA replication and/or DNA processing (e.g., methylation), NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 RNA transcription and/or RNA processing (e.g., removal of intronic sequences and/or translocation from the nucleus), NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide production (e.g., translation of the polypeptide from mRNA, and/or post-translational modification such as glycosylation, phosphorylation, and proteolysis of pro-polypeptides), and/or NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 function (e.g., conformational changes, binding of nucleotides or nucleotide analogs, interaction with binding partners, effect on phosphorylation, and/or effect on occurrence of melanoma). Test molecules and candidate therapeutics include, but are not limited to, compounds, RNAi or siRNA molecules, antisense nucleic acids, ribozymes, NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides or fragments thereof, and immunotherapeutics (e.g., antibodies and HLA-presented polypeptide fragments).

As used herein, the term “system” refers to a cell free in vitro environment and a cell-based environment such as a collection of cells, a tissue, an organ, or an organism. A system is “contacted” with a test molecule in a variety of manners, including adding molecules in solution and allowing them to interact with one another by diffusion, cell injection, and any administration routes in an animal. As used herein, the term “interaction” refers to an effect of a test molecule on a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid, polypeptide, or variant thereof (collectively referred to as a “NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule”), where the effect is sometimes binding between the test molecule and the nucleic acid or polypeptide, and is often an observable change in cells, tissue, or organism.

There are many standard methods for detecting the presence or absence of interaction between a test molecule and a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid or polypeptide. For example, titrametric, acidimetric, radiometric, NMR, monolayer, polarographic, spectrophotometric, fluorescent, and ESR assays probative of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 function may be utilized.

NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activity and/or NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 interactions can be detected and quantified using assays known in the art and described in Examples hereafter.

An interaction can be determined by labeling the test molecule and/or the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule, where the label is covalently or non-covalently attached to the test molecule or NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule. The label is sometimes a radioactive molecule such as ¹²⁵I, ¹³¹I, ³⁵S or ³H, which can be detected by direct counting of radioemission or by scintillation counting. Also, enzymatic labels such as horseradish peroxidase, alkaline phosphatase, or luciferase may be utilized where the enzymatic label can be detected by determining conversion of an appropriate substrate to product. Also, presence or absence of an interaction can be determined without labeling. For example, a microphysiometer (e.g., Cytosensor) is an analytical instrument that measures the rate at which a cell acidifies its environment using a light-addressable potentiometric sensor (LAPS). Changes in this acidification rate can be used as an indication of an interaction between a test molecule and NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 (McConnell, H. M. et al., Science 257: 1906-1912 (1992)).

In cell-based systems, cells typically include a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid or polypeptide or variants thereof and are often of mammalian origin, although the cell can be of any origin. Whole cells, cell homogenates, and cell fractions (e.g., cell membrane fractions) can be subjected to analysis. Where interactions between a test molecule with a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or variant thereof are monitored, soluble and/or membrane bound forms of the polypeptide or variant may be utilized. Where membrane-bound forms of the polypeptide are used, it may be desirable to utilize a solubilizing agent. Examples of such solubilizing agents include non-ionic detergents such as n-octylglucoside, n-dodecylglucoside, n-dodecylmaltoside, octanoyl-N-methylglucamide, decanoyl-N-methylglucamide, Triton® X-100, Triton® X-114, Thesit®, Isotridecypoly(ethylene glycol ether)_n, 3-[(3-cholamidopropyl)dimethylamminio]-1-propane sulfonate (CHAPS), 3-[(3cholamidopropyl)dimethylamminio]-2-hydroxy-1-propane sulfonate (CHAPSO), or N-dodecyl-N,N-dimethyl-3-ammonio-1-propane sulfonate.

An interaction between two molecules can also be detected by monitoring fluorescence energy transfer (FET) (see, for example, Lakowicz et al., U.S. Pat. No. 5,631,169; Stavrianopoulos et al. U.S. Pat. No. 4,868,103). A fluorophore label on a first, “donor” molecule is selected such that its emitted fluorescent energy will be absorbed by a fluorescent label on a second, “acceptor” molecule, which in turn is able to fluoresce due to the absorbed energy. Alternately, the “donor” polypeptide molecule may simply utilize the natural fluorescent energy of tryptophan residues. Labels are chosen that emit different wavelengths of light, such that the “acceptor” molecule label may be differentiated from that of the “donor”. Since the efficiency of energy transfer between the labels is related to the distance separating the molecules, the spatial relationship between the molecules can be assessed. In a situation in which binding occurs between the molecules, the fluorescent emission of the “acceptor” molecule label in the assay should be maximal. An FET binding event can be conveniently measured through standard fluorometric detection means well known in the art (e.g., using a fluorimeter).

In another embodiment, determining the presence or absence of an interaction between a test molecule and a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule can be effected by using real-time Biomolecular Interaction Analysis (BIA) (see, e.g., Sjolander & Urbaniczk, Anal. Chem. 63: 2338-2345 (1991) and Szabo et al., Curr. Opin. Struct. Biol. 5: 699-705 (1995)). “Surface plasmon resonance” or “BIA” detects biospecific interactions in real time, without labeling any of the interactants (e.g., BIAcore). Changes in the mass at the binding surface (indicative of a binding event) result in alterations of the refractive index of light near the surface (the optical phenomenon of surface plasmon resonance (SPR)), resulting in a detectable signal which can be used as an indication of real-time reactions between biological molecules.

In another embodiment, the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule or test molecules are anchored to a solid phase. The NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule/test molecule complexes anchored to the solid phase can be detected at the end of the reaction. The target NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule is often anchored to a solid surface, and the test molecule, which is not anchored, can be labeled, either directly or indirectly, with detectable labels discussed herein.

It may be desirable to immobilize a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule, an anti-NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antibody, or test molecules to facilitate separation of complexed from uncomplexed forms of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecules and test molecules, as well as to accommodate automation of the assay. Binding of a test molecule to a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule can be accomplished in any vessel suitable for containing the reactants. Examples of such vessels include microtitre plates, test tubes, and micro-centrifuge tubes. In one embodiment, a fusion polypeptide can be provided which adds a domain that allows a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule to be bound to a matrix. For example, glutathione-5-transferase/NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 fusion polypeptides or glutathione-5-transferase/target fusion polypeptides can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, Mo.) or glutathione derivatized microtitre plates, which are then combined with the test compound or the test compound and either the non-adsorbed target polypeptide or NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, and the mixture incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads or microtitre plate wells are washed to remove any unbound components, the matrix immobilized in the case of beads, complex determined either directly or indirectly, for example, as described above. Alternatively, the complexes can be dissociated from the matrix, and the level of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 binding or activity determined using standard techniques.

Other techniques for immobilizing a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule on matrices include using biotin and streptavidin. For example, biotinylated NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or target molecules can be prepared from biotin-NHS(N-hydroxy-succinimide) using techniques known in the art (e.g., biotinylation kit, Pierce Chemicals, Rockford, Ill.), and immobilized in the wells of streptavidin-coated 96 well plates (Pierce Chemical).

In order to conduct the assay, the non-immobilized component is added to the coated surface containing the anchored component. After the reaction is complete, unreacted components are removed (e.g., by washing) under conditions such that any complexes formed will remain immobilized on the solid surface. The detection of complexes anchored on the solid surface can be accomplished in a number of ways. Where the previously non-immobilized component is pre-labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the previously non-immobilized component is not pre-labeled, an indirect label can be used to detect complexes anchored on the surface; e.g., using a labeled antibody specific for the immobilized component (the antibody, in turn, can be directly labeled or indirectly labeled with, e.g., a labeled anti-Ig antibody).

In one embodiment, this assay is performed utilizing antibodies reactive with NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or test molecules but which do not interfere with binding of the NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide to its test molecule. Such antibodies can be derivatized to the wells of the plate, and unbound target or NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide trapped in the wells by antibody conjugation. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or target molecule, as well as enzyme-linked assays which rely on detecting an enzymatic activity associated with the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or test molecule.

Alternatively, cell free assays can be conducted in a liquid phase. In such an assay, the reaction products are separated from unreacted components, by any of a number of standard techniques, including but not limited to: differential centrifugation (see, for example, Rivas, G., and Minton, A. P., Trends Biochem Sci August; 18(8): 284-7 (1993)); chromatography (gel filtration chromatography, ion-exchange chromatography); electrophoresis (see, e.g., Ausubel et al., eds. Current Protocols in Molecular Biology, J Wiley: New York (1999)); and immunoprecipitation (see, for example, Ausubel, F. et al., eds. Current Protocols in Molecular Biology, J. Wiley: New York (1999)). Such resins and chromatographic techniques are known to one skilled in the art (see, e.g., Heegaard, J. Mol. Recognit. Winter; 11(1-6): 141-8 (1998); Hage & Tweed, J. Chromatogr. B Biomed. Sci. Appl. October 10; 699 (1-2): 499-525 (1997)). Further, fluorescence energy transfer may also be conveniently utilized, as described herein, to detect binding without further purification of the complex from solution.

In another embodiment, modulators of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 expression are identified. For example, a cell or cell free mixture is contacted with a candidate compound and the expression of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA or polypeptide evaluated relative to the level of expression of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA or polypeptide in the absence of the candidate compound. When expression of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA or polypeptide is greater in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA or polypeptide expression. Alternatively, when expression of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA or polypeptide is less (statistically significantly less) in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA or polypeptide expression. The level of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA or polypeptide expression can be determined by methods described herein for detecting NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 mRNA or polypeptide.

In an embodiment, binding partners that interact with a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule are detected. The NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecules can interact with one or more cellular or extracellular macromolecules, such as polypeptides, in vivo, and these molecules that interact with NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecules are referred to herein as “binding partners.” Molecules that disrupt such interactions can be useful in regulating the activity of the target gene product. Such molecules can include, but are not limited to molecules such as antibodies, peptides, and small molecules (e.g., siRNA). The preferred target genes/products for use in this embodiment are the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 genes herein identified. In an alternative embodiment, provided are methods for determining the ability of the test compound to modulate the activity of a NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide through modulation of the activity of a downstream effector of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 target molecule. For example, the activity of the effector molecule on an appropriate target can be determined, or the binding of the effector to an appropriate target can be determined, as previously described.

To identify compounds that interfere with the interaction between the target gene product and its cellular or extracellular binding partner(s), e.g., a substrate, a reaction mixture containing the target gene product and the binding partner is prepared, under conditions and for a time sufficient, to allow the two products to form complex. In order to test an inhibitory agent, the reaction mixture is provided in the presence and absence of the test compound. The test compound can be initially included in the reaction mixture, or can be added at a time subsequent to the addition of the target gene and its cellular or extracellular binding partner. Control reaction mixtures are incubated without the test compound or with a placebo. The formation of any complexes between the target gene product and the cellular or extracellular binding partner is then detected. The formation of a complex in the control reaction, but not in the reaction mixture containing the test compound, indicates that the compound interferes with the interaction of the target gene product and the interactive binding partner. Additionally, complex formation within reaction mixtures containing the test compound and normal target gene product can also be compared to complex formation within reaction mixtures containing the test compound and mutant target gene product. This comparison can be important in those cases wherein it is desirable to identify compounds that disrupt interactions of mutant but not normal target gene products.

These assays can be conducted in a heterogeneous or homogeneous format. Heterogeneous assays involve anchoring either the target gene product or the binding partner onto a solid phase, and detecting complexes anchored on the solid phase at the end of the reaction. In homogeneous assays, the entire reaction is carried out in a liquid phase. In either approach, the order of addition of reactants can be varied to obtain different information about the compounds being tested. For example, test compounds that interfere with the interaction between the target gene products and the binding partners, e.g., by competition, can be identified by conducting the reaction in the presence of the test substance. Alternatively, test compounds that disrupt preformed complexes, e.g., compounds with higher binding constants that displace one of the components from the complex, can be tested by adding the test compound to the reaction mixture after complexes have been formed. The various formats are briefly described below.

In a heterogeneous assay system, either the target gene product or the interactive cellular or extracellular binding partner, is anchored onto a solid surface (e.g., a microtitre plate), while the non-anchored species is labeled, either directly or indirectly. The anchored species can be immobilized by non-covalent or covalent attachments. Alternatively, an immobilized antibody specific for the species to be anchored can be used to anchor the species to the solid surface.

In order to conduct the assay, the partner of the immobilized species is exposed to the coated surface with or without the test compound. After the reaction is complete, unreacted components are removed (e.g., by washing) and any complexes formed will remain immobilized on the solid surface. Where the non-immobilized species is pre-labeled, the detection of label immobilized on the surface indicates that complexes were formed. Where the non-immobilized species is not pre-labeled, an indirect label can be used to detect complexes anchored on the surface; e.g., using a labeled antibody specific for the initially non-immobilized species (the antibody, in turn, can be directly labeled or indirectly labeled with, e.g., a labeled anti-Ig antibody). Depending upon the order of addition of reaction components, test compounds that inhibit complex formation or that disrupt preformed complexes can be detected.

Alternatively, the reaction can be conducted in a liquid phase in the presence or absence of the test compound, the reaction products separated from unreacted components, and complexes detected; e.g., using an immobilized antibody specific for one of the binding components to anchor any complexes formed in solution, and a labeled antibody specific for the other partner to detect anchored complexes. Again, depending upon the order of addition of reactants to the liquid phase, test compounds that inhibit complex or that disrupt preformed complexes can be identified.

In an alternate embodiment, a homogeneous assay can be used. For example, a preformed complex of the target gene product and the interactive cellular or extracellular binding partner product is prepared in that either the target gene products or their binding partners are labeled, but the signal generated by the label is quenched due to complex formation (see, e.g., U.S. Pat. No. 4,109,496 that utilizes this approach for immunoassays). The addition of a test substance that competes with and displaces one of the species from the preformed complex will result in the generation of a signal above background. In this way, test substances that disrupt target gene product-binding partner interaction can be identified.

Also, binding partners of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecules can be identified in a two-hybrid assay or three-hybrid assay (see, e.g., U.S. Pat. No. 5,283,317; Zervos et al., Cell 72: 223-232 (1993); Madura et al., J. Biol. Chem. 268: 12046-12054 (1993); Bartel et al., Biotechniques 14: 920-924 (1993); Iwabuchi et al., Oncogene 8: 1693-1696 (1993); and Brent WO94/10300), to identify other polypeptides, which bind to or interact with NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 (“NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2-binding polypeptides” or “NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2-bp”) and are involved in NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activity. Such NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2-bps can be activators or inhibitors of signals by the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides or NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 targets as, for example, downstream elements of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2-mediated signaling pathway.

A two-hybrid system is based on the modular nature of most transcription factors, which consist of separable DNA-binding and activation domains. Briefly, the assay utilizes two different DNA constructs. In one construct, the gene that codes for a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In the other construct, a DNA sequence, from a library of DNA sequences, that encodes an unidentified polypeptide (“prey” or “sample”) is fused to a gene that codes for the activation domain of the known transcription factor. (Alternatively the: NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide can be the fused to the activator domain.) If the “bait” and the “prey” polypeptides are able to interact, in vivo, forming a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g., LacZ) which is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene which encodes the polypeptide which interacts with the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide.

Candidate therapeutics for treating melanoma are identified from a group of test molecules that interact with a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid or polypeptide. Test molecules often are ranked according to the degree with which they interact or modulate (e.g., agonize or antagonize) DNA replication and/or processing, RNA transcription and/or processing, polypeptide production and/or processing, and/or function of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecules, for example, and then top ranking modulators are selected. Also, pharmacogenomic information described herein can determine the rank of a modulator. Candidate therapeutics typically are formulated for administration to a subject.

Therapeutic Treatments

Formulations or pharmaceutical compositions typically include in combination with a pharmaceutically acceptable carrier a compound, an antisense nucleic acid, a ribozyme, an antibody, a binding partner that interacts with a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid, or a fragment thereof. The formulated molecule may be one that is identified by a screening method described above. Also, formulations may comprise a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or fragment thereof and a pharmaceutically acceptable carrier. As used herein, the term “pharmaceutically acceptable carrier” includes solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like, compatible with pharmaceutical administration. Supplementary active compounds can also be incorporated into the compositions.

A pharmaceutical composition is formulated to be compatible with its intended route of administration. Examples of routes of administration include parenteral, e.g., intravenous, intradermal, subcutaneous, oral (e.g., inhalation), transdermal (topical), transmucosal, and rectal administration. Solutions or suspensions used for parenteral, intradermal, or subcutaneous application can include the following components: a sterile diluent such as water for injection, saline solution, fixed oils, polyethylene glycols, glycerin, propylene glycol or other synthetic solvents; antibacterial agents such as benzyl alcohol or methyl parabens; antioxidants such as ascorbic acid or sodium bisulfite; chelating agents such as ethylenediaminetetraacetic acid; buffers such as acetates, citrates or phosphates and agents for the adjustment of tonicity such as sodium chloride or dextrose. pH can be adjusted with acids or bases, such as hydrochloric acid or sodium hydroxide. The parenteral preparation can be enclosed in ampoules, disposable syringes or multiple dose vials made of glass or plastic.

Oral compositions generally include an inert diluent or an edible carrier. For the purpose of oral therapeutic administration, the active compound can be incorporated with excipients and used in the form of tablets, troches, or capsules, e.g., gelatin capsules. Oral compositions can also be prepared using a fluid carrier for use as a mouthwash. Pharmaceutically compatible binding agents, and/or adjuvant materials can be included as part of the composition. The tablets, pills, capsules, troches and the like can contain any of the following ingredients, or compounds of a similar nature: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel, or corn starch; a lubricant such as magnesium stearate or Sterotes; a glidant such as colloidal silicon dioxide; a sweetening agent such as sucrose or saccharin; or a flavoring agent such as peppermint, methyl salicylate, or orange flavoring.

Pharmaceutical compositions suitable for injectable use include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion. For intravenous administration, suitable carriers include physiological saline, bacteriostatic water, Cremophor EL™ (BASF, Parsippany, N.J.) or phosphate buffered saline (PBS). In all cases, the composition must be sterile and should be fluid to the extent that easy syringability exists. It should be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof. The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars, polyalcohols such as mannitol, sorbitol, sodium chloride in the composition. Prolonged absorption of the injectable compositions can be brought about by including in the composition an agent which delays absorption, for example, aluminum monostearate and gelatin.

Sterile injectable solutions can be prepared by incorporating the active compound in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by filtered sterilization. Generally, dispersions are prepared by incorporating the active compound into a sterile vehicle which contains a basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, the methods of preparation often utilized are vacuum drying and freeze-drying which yields a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.

For administration by inhalation, the compounds are delivered in the form of an aerosol spray from pressured container or dispenser which contains a suitable propellant, e.g., a gas such as carbon dioxide, or a nebulizer.

Systemic administration can also be by transmucosal or transdermal means. For transmucosal or transdermal administration, penetrants appropriate to the barrier to be permeated are used in the formulation. Such penetrants are generally known in the art, and include, for example, for transmucosal administration, detergents, bile salts, and fusidic acid derivatives. Transmucosal administration can be accomplished through the use of nasal sprays or suppositories. For transdermal administration, the active compounds are formulated into ointments, salves, gels, or creams (e.g., sunscreen) as generally known in the art. Molecules can also be prepared in the form of suppositories (e.g., with conventional suppository bases such as cocoa butter and other glycerides) or retention enemas for rectal delivery.

In one embodiment, active molecules are prepared with carriers that will protect the compound against rapid elimination from the body, such as a controlled release formulation, including implants and microencapsulated delivery systems. Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid. Methods for preparation of such formulations will be apparent to those skilled in the art. Materials can also be obtained commercially from Alza Corporation and Nova Pharmaceuticals, Inc. Liposomal suspensions (including liposomes targeted to infected cells with monoclonal antibodies to viral antigens) can also be used as pharmaceutically acceptable carriers. These can be prepared according to methods known to those skilled in the art, for example, as described in U.S. Pat. No. 4,522,811.

It is advantageous to formulate oral or parenteral compositions in dosage unit form for ease of administration and uniformity of dosage. Dosage unit form as used herein refers to physically discrete units suited as unitary dosages for the subject to be treated; each unit containing a predetermined quantity of active compound calculated to produce the desired therapeutic effect in association with the required pharmaceutical carrier.

Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD₅₀ (the dose lethal to 50% of the population) and the ED₅₀ (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD₅₀/ED₅₀. Molecules which exhibit high therapeutic indices often are utilized. While molecules that exhibit toxic side effects may be used, care should be taken to design a delivery system that targets such compounds to the site of affected tissue in order to minimize potential damage to uninfected cells and, thereby, reduce side effects.

The data obtained from the cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such molecules lies preferably within a range of circulating concentrations that include the ED₅₀ with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any molecules used in the method, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range that includes the IC₅₀ (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography.

As defined herein, a therapeutically effective amount of protein or polypeptide (i.e., an effective dosage) ranges from about 0.001 to 30 mg/kg body weight, sometimes about 0.01 to 25 mg/kg body weight, often about 0.1 to 20 mg/kg body weight, and more often about 1 to 10 mg/kg, 2 to 9 mg/kg, 3 to 8 mg/kg, 4 to 7 mg/kg, or 5 to 6 mg/kg body weight. The protein or polypeptide can be administered one time per week for between about 1 to 10 weeks, sometimes between 2 to 8 weeks, often between about 3 to 7 weeks, and more often for about 4, 5, or 6 weeks. The skilled artisan will appreciate that certain factors may influence the dosage and timing required to effectively treat a subject, including but not limited to the severity of the disease or disorder, previous treatments, the general health and/or age of the subject, and other diseases present. Moreover, treatment of a subject with a therapeutically effective amount of a protein, polypeptide, or antibody can include a single treatment or, preferably, can include a series of treatments.

With regard to polypeptide formulations, featured herein is a method for treating melanoma in a subject, which comprises contacting one or more cells in the subject with a first NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide, where genomic DNA in the subject comprises a second NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid having one or more polymorphic variations associated with melanoma. The first NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide comprises fewer polymorphic variations associated with melanoma than the second NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. The first and second NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides are encoded by a nucleic acid which comprises a nucleotide sequence selected from the group consisting of the nucleotide sequence of SEQ ID NO: 1-17; a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence set forth in SEQ ID NO: 18-27; and a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence set forth in SEQ ID NO: 18-27. The second NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide also may be encoded by a fragment of the foregoing nucleic acids comprising the one or more polymorphic variations. The subject is often a human.

For antibodies, a dosage of 0.1 mg/kg of body weight (generally 10 mg/kg to 20 mg/kg) is often utilized. If the antibody is to act in the brain, a dosage of 50 mg/kg to 100 mg/kg is often appropriate. Generally, partially human antibodies and fully human antibodies have a longer half-life within the human body than other antibodies. Accordingly, lower dosages and less frequent administration is often possible. Modifications such as lipidation can be used to stabilize antibodies and to enhance uptake and tissue penetration (e.g., into the brain). A method for lipidation of antibodies is described by Cruikshank et al., J. Acquired Immune Deficiency Syndromes and Human Retrovirology 14: 193 (1997).

Antibody conjugates can be used for modifying a given biological response, the drug moiety is not to be construed as limited to classical chemical therapeutic agents. For example, the drug moiety may be a protein or polypeptide possessing a desired biological activity. Such proteins may include, for example, a toxin such as abrin, ricin A, pseudomonas exotoxin, or diphtheria toxin; a polypeptide such as tumor necrosis factor, .alpha.-interferon, .beta.-interferon, nerve growth factor, platelet derived growth factor, tissue plasminogen activator; or, biological response modifiers such as, for example, lymphokines, interleukin-1 (“IL-1”), interleukin-2 (“IL-2”), interleukin-6 (“IL-6”), granulocyte macrophage colony stimulating factor (“GM-CSF”), granulocyte colony stimulating factor (“G-CSF”), or other growth factors. Alternatively, an antibody can be conjugated to a second antibody to form an antibody heteroconjugate as described by Segal in U.S. Pat. No. 4,676,980.

For compounds, exemplary doses include milligram or microgram amounts of the compound per kilogram of subject or sample weight, for example, about 1 microgram per kilogram to about 500 milligrams per kilogram, about 100 micrograms per kilogram to about 5 milligrams per kilogram, or about 1 microgram per kilogram to about 50 micrograms per kilogram. It is understood that appropriate doses of a small molecule depend upon the potency of the small molecule with respect to the expression or activity to be modulated. When one or more of these small molecules is to be administered to an animal (e.g., a human) in order to modulate expression or activity of a polypeptide or nucleic acid, a physician, veterinarian, or researcher may, for example, prescribe a relatively low dose at first, subsequently increasing the dose until an appropriate response is obtained. In addition, it is understood that the specific dose level for any particular animal subject will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, gender, and diet of the subject, the time of administration, the route of administration, the rate of excretion, any drug combination, and the degree of expression or activity to be modulated.

NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid molecules can be inserted into vectors and used in gene therapy methods for treating melanoma. Featured herein is a method for treating melanoma in a subject, which comprises contacting one or more cells in the subject with a first NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid. Genomic DNA in the subject comprises a second NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid comprising one or more polymorphic variations associated with melanoma, and the first NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid comprises fewer polymorphic variations associated with melanoma. The first and second NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acids typically comprise a nucleotide sequence selected from the group consisting of the nucleotide sequence of SEQ ID NO: 1-17; a nucleotide sequence which encodes a polypeptide consisting of an amino acid sequence set forth in SEQ ID NO: 18-27; and a nucleotide sequence which encodes a polypeptide that is 90% or more identical to an amino acid sequence set forth in SEQ ID NO: 18-27. The second NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid may also be a fragment of the foregoing comprising one or more polymorphic variations. The subject is often a human.

Gene therapy vectors can be delivered to a subject by, for example, intravenous injection, local administration (see U.S. Pat. No. 5,328,470) or by stereotactic injection (see e.g., Chen et al., (1994) Proc. Natl. Acad. Sci. USA 91: 3054-3057). Pharmaceutical preparations of gene therapy vectors can include a gene therapy vector in an acceptable diluent, or can comprise a slow release matrix in which the gene delivery vehicle is imbedded. Alternatively, where the complete gene delivery vector can be produced intact from recombinant cells (e.g., retroviral vectors) the pharmaceutical preparation can include one or more cells which produce the gene delivery system. Examples of gene delivery vectors are described herein.

Pharmaceutical compositions can be included in a container, pack, or dispenser together with instructions for administration.

Pharmaceutical compositions of active ingredients can be administered by any of the paths described herein for therapeutic and prophylactic methods for treating melanoma. With regard to both prophylactic and therapeutic methods of treatment, such treatments may be specifically tailored or modified, based on knowledge obtained from pharmacogenomic analyses described herein. As used herein, the term “treatment” is defined as the application or administration of a therapeutic agent to a patient, or application or administration of a therapeutic agent to an isolated tissue or cell line from a patient, who has a disease, a symptom of disease or a predisposition toward a disease, with the purpose to cure, heal, alleviate, relieve, alter, remedy, ameliorate, improve or affect the disease, the symptoms of disease or the predisposition toward disease. A therapeutic agent includes, but is not limited to, small molecules, peptides, antibodies, ribozymes and antisense oligonucleotides.

Administration of a prophylactic agent can occur prior to the manifestation of symptoms characteristic of the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 aberrance, such that a disease or disorder is prevented or, alternatively, delayed in its progression. Depending on the type of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 aberrance, for example, a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecule, NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 agonist, or NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antagonist agent can be used for treating the subject. The appropriate agent can be determined based on screening assays described herein.

As discussed, successful treatment of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 disorders can be brought about by tech niques that serve to inhibit the expression or activity of target gene products. For example, compounds (e.g., an agent identified using an assays described above) that exhibit negative modulatory activity can be used to prevent and/or treat melanoma. Such molecules can include, but are not limited to peptides, phosphopeptides, small organic or inorganic molecules, or antibodies (including, for example, polyclonal, monoclonal, humanized, anti-idiotypic, chimeric or single chain antibodies, and FAb, F(ab′)₂ and FAb expression library fragments, scFV molecules, and epitope-binding fragments thereof).

Further, antisense and ribozyme molecules that inhibit expression of the target gene can also be used to reduce the level of target gene expression, thus effectively reducing the level of target gene activity. Still further, triple helix molecules can be utilized in reducing the level of target gene activity. Antisense, ribozyme and triple helix molecules are discussed above.

It is possible that the use of antisense, ribozyme, and/or triple helix molecules to reduce or inhibit mutant gene expression can also reduce or inhibit the transcription (triple helix) and/or translation (antisense, ribozyme) of mRNA produced by normal target gene alleles, such that the concentration of normal target gene product present can be lower than is necessary for a normal phenotype. In such cases, nucleic acid molecules that encode and express target gene polypeptides exhibiting normal target gene activity can be introduced into cells via gene therapy method. Alternatively, in instances in that the target gene encodes an extracellular polypeptide, it can be preferable to co-administer normal target gene polypeptide into the cell or tissue in order to maintain the requisite level of cellular or tissue target gene activity.

Another method by which nucleic acid molecules may be utilized in treating or preventing a disease characterized by NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 expression is through the use of aptamer molecules specific for NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. Aptamers are nucleic acid molecules having a tertiary structure which permits them to specifically bind to polypeptide ligands (see, e.g., Osborne, et al., Curr. Opin. Chem. Biol. 1 (1): 5-9 (1997); and Patel, D. J., Curr. Opin. Chem. Biol. June; 1 (1): 3246 (1997)). Since nucleic acid molecules may in many cases be more conveniently introduced into target cells than therapeutic polypeptide molecules may be, aptamers offer a method by which NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide activity may be specifically decreased without the introduction of drugs or other molecules which may have pluripotent effects.

Antibodies can be generated that are both specific for target gene product and that reduce target gene product activity. Such antibodies may, therefore, by administered in instances whereby negative modulatory techniques are appropriate for the treatment of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 disorders. For a description of antibodies, see the Antibody section above.

In circumstances where injection of an animal or a human subject with a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or epitope for stimulating antibody production is harmful to the subject, it is possible to generate an immune response against NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 through the use of anti-idiotypic antibodies (see, for example, Herlyn, D., Ann. Med.; 31(1): 66-78 (1999); and Bhattacharya-Chatterjee & Foon, Cancer Treat. Res.; 94: 51-68 (1998)). If an anti-idiotypic antibody is introduced into a mammal or human subject, it should stimulate the production of anti-anti-idiotypic antibodies, which should be specific to the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide. Vaccines directed to a disease characterized by NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 expression may also be generated in this fashion.

In instances where the target antigen is intracellular and whole antibodies are used, internalizing antibodies often are utilized. Lipofectin or liposomes can be used to deliver the antibody or a fragment of the Fab region that binds to the target antigen into cells. Where fragments of the antibody are used, the smallest inhibitory fragment that binds to the target antigen often are utilized. For example, peptides having an amino acid sequence corresponding to the Fv region of the antibody can be used. Alternatively, single chain neutralizing antibodies that bind to intracellular target antigens can also be administered. Such single chain antibodies can be administered, for example, by expressing nucleotide sequences encoding single-chain antibodies within the target cell population (see e.g., Marasco et al., Proc. Natl. Acad. Sci. USA 90: 7889-7893 (1993)).

NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecules and compounds that inhibit target gene expression, synthesis and/or activity can be administered to a patient at therapeutically effective doses to prevent, treat or ameliorate NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 disorders. A therapeutically effective dose refers to that amount of the compound sufficient to result in amelioration of symptoms of the disorders.

Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD₅₀ (the dose lethal to 50% of the population) and the ED₅₀ (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD₅₀/ED₅₀. Compounds that exhibit large therapeutic indices often are utilized. While compounds that exhibit toxic side effects can be used, care should be taken to design a delivery system that targets such compounds to the site of affected tissue in order to minimize potential damage to uninfected cells and, thereby, reduce side effects.

Data obtained from cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such compounds lies preferably within a range of circulating concentrations that include the ED₅₀ with little or no toxicity. The dosage can vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used, the therapeutically effective dose can be estimated initially from cell culture assays. A dose can be formulated in animal models to achieve a circulating plasma concentration range that includes the IC₅₀ (i.e., the concentration of the test compound that achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma can be measured, for example, by high performance liquid chromatography.

Another example of effective dose determination for an individual is the ability to directly assay levels of “free” and “bound” compound in the serum of the test subject. Such assays may utilize antibody mimics and/or “biosensors” that have been created through molecular imprinting techniques.

The compound which is able to modulate NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activity is used as a template, or “imprinting molecule”, to spatially organize polymerizable monomers prior to their polymerization with catalytic reagents. The subsequent removal of the imprinted molecule leaves a polymer matrix which contains a repeated “negative image” of the compound and is able to selectively rebind the molecule under biological assay conditions. A detailed review of this technique can be seen in Ansell et al., Current Opinion in Biotechnology 7: 89-94 (1996) and in Shea, Trends in Polymer Science 2: 166-173 (1994). Such “imprinted” affinity matrixes are amenable to ligand-binding assays, whereby the immobilized monoclonal antibody component is replaced by an appropriately imprinted matrix. An example of the use of such matrixes in this way can be seen in Vlatakis, et al., Nature 361: 645-647 (1993). Through the use of isotope-labeling, the “free” concentration of compound which modulates the expression or activity of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 can be readily monitored and used in calculations of IC₅₀. Such “imprinted” affinity matrixes can also be designed to include fluorescent groups whose photon-emitting properties measurably change upon local and selective binding of target compound. These changes can be readily assayed in real time using appropriate fiberoptic devices, in turn allowing the dose in a test subject to be quickly optimized based on its individual IC₅₀. A rudimentary example of such a “biosensor” is discussed in Kriz et al., Analytical Chemistry 67: 2142-2144 (1995).

Provided herein are methods of modulating NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 expression or activity for therapeutic purposes. Accordingly, in an exemplary embodiment, the modulatory method involves contacting a cell with NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 or an agent that modulates one or more activities of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide activity associated with the cell. An agent that modulates NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide activity can be an agent as described herein, such as a nucleic acid or a polypeptide, a naturally-occurring target molecule of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide (e.g., a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 substrate or receptor), a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antibody, a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 agonist or antagonist, a peptidomimetic of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 agonist or antagonist, or other small molecule.

In one embodiment, the agent stimulates one or more NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activities. Examples of such stimulatory agents include active NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide and a nucleic acid molecule encoding NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2. In another embodiment, the agent inhibits one or more NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activities. Examples of such inhibitory agents include antisense NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acid molecules, anti-NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 antibodies, and NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 inhibitors. These modulatory methods can be performed in vitro (e.g., by culturing the cell with the agent) or, alternatively, in vivo (e.g., by administering the agent to a subject). As such, provided are methods of treating an individual afflicted with a disease or disorder characterized by aberrant or unwanted expression or activity of a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or nucleic acid molecule. In one embodiment, the method involves administering an agent (e.g., an agent identified by a screening assay described herein), or combination of agents that modulates (e.g., upregulates or downregulates) NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 expression or activity. In another embodiment, the method involves administering a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptide or nucleic acid molecule as therapy to compensate for reduced, aberrant, or unwanted NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 expression or activity.

Stimulation of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activity is desirable in situations in which NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 is abnormally downregulated and/or in which increased NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activity is likely to have a beneficial effect. For example, stimulation of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activity is desirable in situations in which a NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 is downregulated and/or in which increased NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activity is likely to have a beneficial effect. Likewise, inhibition of NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activity is desirable in situations in which NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 is abnormally upregulated and/or in which decreased NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 activity is likely to have a beneficial effect.

The examples set forth below are intended to illustrate but not limit the invention.

EXAMPLES

In the following studies a group of subjects were selected according to specific parameters relating to melanoma. Nucleic acid samples obtained from individuals in the study group were subjected to genetic analysis, which identified associations between melanoma and certain polymorphic regions in the NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 genes. Methods are described for producing NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 polypeptides and polypeptide variants in vitro or in vivo. NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 nucleic acids or polypeptides and variants thereof are utilized for screening test molecules for those that interact with NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecules. Test molecules identified as interactors with NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO or REPS2 molecules and variants are further screened in vivo to determine whether they treat melanoma.

Example 1

Samples and Pooling Strategies

Sample Selection

Blood samples were collected from individuals diagnosed with melanoma, which were referred to as case samples. Also, blood samples were collected from individuals not diagnosed with melanoma or a history of melanoma; these samples served as gender and age-matched controls. A database was created that listed all phenotypic trait information gathered from individuals for each case and control sample. Genomic DNA was extracted from each of the blood samples for genetic analyses.

DNA Extraction from Blood Samples

Six to ten milliliters of whole blood was transferred to a 50 ml tube containing 27 ml of red cell lysis solution (RCL). The tube was inverted until the contents were mixed. Each tube was incubated for 10 minutes at room temperature and inverted once during the incubation. The tubes were then centrifuged for 20 minutes at 3000×g and the supernatant was carefully poured off. 100-200 μl of residual liquid was left in the tube and was pipetted repeatedly to resuspend the pellet in the residual supernatant. White cell lysis solution (WCL) was added to the tube and pipetted repeatedly until completely mixed. While no incubation was normally required, the solution was incubated at 37° C. or room temperature if cell clumps were visible after mixing until the solution was homogeneous. Two ml of protein precipitation was added to the cell lysate. The mixtures were vortexed vigorously at high speed for 20 sec to mix the protein precipitation solution uniformly with the cell lysate, and then centrifuged for 10 minutes at 3000×g. The supernatant containing the DNA was then poured into a clean 15 ml tube, which contained 7 ml of 100% isopropanol. The samples were mixed by inverting the tubes gently until white threads of DNA were visible. Samples were centrifuged for 3 minutes at 2000×g and the DNA was visible as a small white pellet. The supernatant was decanted and 5 ml of 70% ethanol was added to each tube. Each tube was inverted several times to wash the DNA pellet, and then centrifuged for 1 minute at 2000×g. The ethanol was decanted and each tube was drained on clean absorbent paper. The DNA was dried in the tube by inversion for 10 minutes, and then 1000 μl of 1×TE was added. The size of each sample was estimated, and less TE buffer was added during the following DNA hydration step if the sample was smaller. The DNA was allowed to rehydrate overnight at room temperature, and DNA samples were stored at 2-8° C.

DNA was quantified by placing samples on a hematology mixer for at least 1 hour. DNA was serially diluted (typically 1:80, 1:160, 1:320, and 1:640 dilutions) so that it would be within the measurable range of standards. 125 μl of diluted DNA was transferred to a clear U-bottom microtitre plate, and 125 μl of 1×TE buffer was transferred into each well using a multichannel pipette. The DNA and 1×TE were mixed by repeated pipetting at least 15 times, and then the plates were sealed. 50 μl of diluted DNA was added to wells A5-H12 of a black flat bottom microtitre plate. Standards were inverted six times to mix them, and then 50 μl of 1×TE buffer was pipetted into well A1, 1000 ng/ml of standard was pipetted into well A2, 500 ng/ml of standard was pipetted into well A3, and 250 ng/ml of standard was pipetted into well A4. PicoGreen (Molecular Probes, Eugene, Oreg.) was thawed and freshly diluted 1:200 according to the number of plates that were being measured. PicoGreen was vortexed and then 501 μl was pipetted into all wells of the black plate with the diluted DNA. DNA and PicoGreen were mixed by pipetting repeatedly at least 10 times with the multichannel pipette. The plate was placed into a Fluoroskan Ascent Machine (microplate fluorometer produced by Labsystems) and the samples were allowed to incubate for 3 minutes before the machine was run using filter pairs 485 nm excitation and 538 nm emission wavelengths. Samples having measured DNA concentrations of greater than 450 ng/μl were re-measured for conformation. Samples having measured DNA concentrations of 20 ng/μl or less were re-measured for confirmation.

Pooling Strategies

Samples were placed into one of four groups, based on gender and disease status. The four groups were male case samples, male control samples, female case samples, and female control samples. A select set of samples from each group were utilized to generate pools, and one pool was created for each group. Each individual sample in a pool was represented by an equal amount of genomic DNA. For example, where 25 ng of genomic DNA was utilized in each PCR reaction and there were 200 individuals in each pool, each individual would provide 125 pg of genomic DNA. Inclusion or exclusion of samples for a pool was based upon the following criteria: the sample was derived from an individual characterized as Caucasian; the sample was derived from an individual of German paternal and maternal descent; the database included relevant phenotype information for the individual; case samples were derived from individuals diagnosed with melanoma; control samples were derived from individuals free of cancer; and sufficient genomic DNA was extracted from each blood sample for all allelotyping and genotyping reactions performed during the study. Phenotype information included sex of the individual, number of nevi (few, moderate, numerous), hair color (black, brown, blond, red), diagnosed with melanoma (tumor thickness, date of primary diagnosis, age of individual as of primary diagnosis, post-operative tumor classification, presence of nodes, occurrence of metastases, subtype, location), country or origin of mother and father, presence of certain conditions for each individual (coronary heart disease, cardiomyopathy, arteriosclerosis, abnormal blood clotting/thrombosis, emphysema, asthma, diabetes type 1, diabetes type 2, Alzheimer's disease, epilepsy, schizophrenia, manic depression/bipolar disorder, autoimmune disease, thyroid disorder, and hypertension), presence of cancer in the donor individual or blood relative (melanoma, basaliom/spinaliom/lentigo malignant/mycosis fungoides, breast cancer, colon cancer, rectum cancer, lung cancer, lung cancer, bronchus cancer, prostate cancer, stomach cancer, leukemia, lymphoma, or other cancer in donor, donor parent, donor aunt or uncle, donor offspring or donor grandparent. Samples that met these criteria were added to appropriate pools based on gender and disease status.

The selection process yielded the pools set forth in Table 1, which were used in the studies that follow:

	TABLE 1
	Male	Male	Female	Female
	control	case	control	case
Pool size (Number)	217	236	233	266
Pool Criteria	control	case	control	case
(ex: case/control)
Mean Age (ex: years)	48	51	47	49

Example 2

Association of Polymorphic Variants with Melanoma

A whole-genome screen was performed to identify particular SNPs associated with occurrence of melanoma. As described in Example 1, two sets of samples were utilized: female individuals having melanoma (female cases) and samples from female individuals not having melanoma or any history of melanoma (female controls), and male individuals having melanoma (male cases) and samples from male individuals not having melanoma or any history of melanoma (male controls). The initial screen of each pool was performed in an allelotyping study, in which certain samples in each group were pooled. By pooling DNA from each group, an allele frequency for each SNP in each group was calculated. These allele frequencies were then compared to one another. Particular SNPs were considered as being associated with melanoma when allele frequency differences calculated between case and control pools were statistically significant. SNP disease association results obtained from the allelotyping study were then validated by genotyping each associated SNP across all samples from each pool. The results of the genotyping were then analyzed, allele frequencies for each group were calculated from the individual genotyping results, and a p-value was calculated to determine whether the case and control groups had statistically significantly differences in allele frequencies for a particular SNP. When the genotyping results agreed with the original allelotyping results, the SNP disease association was considered validated at the genetic level.

SNP Panel Used for Genetic Analyses

A whole-genome SNP screen began with an initial screen of approximately 25,000 SNPs over each set of disease and control samples using a pooling approach. The pools studied in the screen are described in Example 1. The SNPs analyzed in this study were part of a set of 25,488 SNPs confirmed as being statistically polymorphic as each is characterized as having a minor allele frequency of greater than 10%. The SNPs in the set reside in genes or in close proximity to genes, and many reside in gene exons. Specifically, SNPs in the set are located in exons, introns, and within 5,000 base-pairs upstream of a transcription start site of a gene. In addition, SNPs were selected according to the following criteria: they are located in ESTs; they are located in Locuslink or Ensembl genes; and they are located in Genomatix promoter predictions. SNPs in the set were also selected on the basis of even spacing across the genome, as depicted in Table 2.

TABLE 2
General Statistics	Spacing Statistics
Total # of SNPs	28,532	Median	34,424	bp
# of Exonic SNPs	8,497 (30%)	Minimum*	1,000	bp
# SNPs with	26,625 (93%)	Maximum*	3,000,000	bp
refSNP ID
Gene Coverage	23,874	Mean	122,412	bp
Chromosome	All	Std	354,	bp
Coverage		Deviation
*Excludes outliers

Genotyping Results

The genetic studies summarized above and described in more detail below identified allelic variants associated with melanoma. The allelic variants identified from the SNP panel described in Table 2 are summarized below in Table 3.

TABLE 3
							Melanoma
SNP	Chromo-	Contig	Contig	Sequence	Sequence	Allelic	Associated
Reference	some	Identification	Position	Identification	Position	Variability	Allele
rs1360457	10	NT_008862	15592254	NM_003873	intronic	T/C	T
rs753050	14	NT_026437	32425413	NM_007361	intronic	A/G	A
rs729647	17	NT_010940	19400937	NM_006039	intronic	A/G	G
rs8404	16	89506442	NT_010542	1320117	NM_003674	UTR	C/T
rs1044639	7	82063609	NT_007933	7685796	XM_168530	UTR	C/A
rs2034453	1	74082116	NT_032977	36275269	NM_015978	intronic	A/G
rs2034453	1		NT_032977		NM_003838	intragenic
rs1904528	X	12970302	NT_011757	12970302	NM_004726	UTR	C/T

Table 3 includes information pertaining to the incident polymorphic variant associated with melanoma identified herein. Public information pertaining to the polymorphism and the genomic sequence that includes the polymorphism are indicated. The genomic sequence identified in Table 3 may be accessed at the http address www.ncbi.nih.gov/entrez/query.fcgi, for example, by using the publicly available SNP reference number (e.g., rs1360457). The chromosome position refers to the position of the SNP within NCBI's Genome Build 34 and dbSNP 119, which may be accessed at the following http address: www.ncbi.nlm.nih.gov/mapview/map_search.cgi?chr=hum_chr.inf&query=. The “Contig Position” provided in Table 3 corresponds to a nucleotide position set forth in the contig sequence, and designates the polymorphic site corresponding to the SNP reference number. The sequence containing the polymorphisms also may be referenced by the “Sequence Identification” set forth in Table 3. The “Sequence Identification” corresponds to cDNA sequence that encodes associated target polypeptides (e.g., NRP1 of the invention. The position of the SNP within the cDNA sequence is provided in the “Sequence Position” column of Table 3. In the case of rs2034453, genetic evidence suggests an association with a region on chromosome 1 band p31.1 that includes two genes: fucose-1-phosphate guanylyltransferase (FPGT) (NM_—003838) and cardiac ankyrin repeat kinase (CARK) (NM_—015978). Also, the allelic variation at the polymorphic site and the allelic variant identified as associated with melanoma is specified in Table 3. All nucleotide sequences referenced and accessed by the parameters set forth in Table 3 are incorporated herein by reference.

Assay for Verifying, Allelotyping, and Genotyping SNPs

A MassARRAY™ system (Sequenom, Inc.) was utilized to perform SNP genotyping in a high-throughput fashion. This genotyping platform was complemented by a homogeneous, single-tube assay method (hME™ or homogeneous MassEXTEND™ (Sequenom, Inc.)) in which two genotyping primers anneal to and amplify a genomic target surrounding a polymorphic site of interest. A third primer (the MassEXTEND™ primer), which is complementary to the amplified target up to but not including the polymorphism, was then enzymatically extended one or a few bases through the polymorphic site and then terminated.

For each polymorphism, SpectroDESIGNER™ software (Sequenom, Inc.) was used to generate a set of PCR primers and a MassEXTEND™ primer which where used to genotype the polymorphism. Other primer design software could be used or one of ordinary skill in the art could manually design primers based on his or her knowledge of the relevant factors and considerations in designing such primers. Table 4 shows PCR primers and Table 5 shows extension primers used for analyzing the polymorphism set forth in Table 3. The initial PCR amplification reaction was performed in a 5 μl total volume containing 1×PCR buffer with 1.5 mM MgCl₂ (Qiagen), 200 μM each of dATP, dGTP, dCTP, dTTP (Gibco-BRL), 2.5 ng of genomic DNA, 0.1 units of HotStar DNA polymerase (Qiagen), and 200 nM each of forward and reverse PCR primers specific for the polymorphic region of interest.

TABLE 4
PCR Primers
SNP
Reference	Forward PCR primer	Reverse PCR primer
rs1360457	TTGTCCCAACTGAGGCTTTG	AACAGCCTTTCAGCTTTGGC
rs753050	ACGTTGGATGCCTCTGTTTCCAACTCAAGG	ACGTTGGATGTTCACAGAGGTTACTAAGGG
rs729647	AACCAACCCACTGGGTTGAC	TGATCTGGGAGAGTTTGGAG
rs8404	GCCTCCTGTTGGGTCCTC	AAGGTATGGGGTGGGAGC
rs1044639	CGCAAACAAAAAGGACACAC	CTCCTTTGTTTCCACCATCC
rs2034453	TTGCTGGACAATAGAAAGAC	GTGACTGGAAACTGAGAATG
rs1904528	GAAGACTGAAAAAAATCCACG	GCTATCTCTTTCACATTGCTC

Samples were incubated at 95° C. for 15 minutes, followed by 45 cycles of 95° C. for 20 seconds, 56° C. for 30 seconds, and 72° C. for 1 minute, finishing with a 3 minute final extension at 72° C. Following amplification, shrimp alkaline phosphatase (SAP) (0.3 units in a 2 μl volume) (Amersham Pharmacia) was added to each reaction (total reaction volume was 7 μl) to remove any residual dNTPs that were not consumed in the PCR step. Samples were incubated for 20 minutes at 37° C., followed by 5 minutes at 85° C. to denature the SAP.

Once the SAP reaction was complete, a primer extension reaction was initiated by adding a polymorphism-specific MassEXTEND™ primer cocktail to each sample. Each MassEXTEND™ cocktail included a specific combination of dideoxynucleotides (ddNTPs) and deoxynucleotides (dNTPs) used to distinguish polymorphic alleles from one another. Methods for verifying, allelotyping and genotyping SNPs are disclosed, for example, in U.S. Pat. No. 6,258,538, the content of which is hereby incorporated by reference. In Table 5, ddNTPs are shown and the fourth nucleotide not shown is the dNTP.

TABLE 5
Extension Primers
SNP		Termination
Reference	Extend Probe	Mix
rs1360457	CAGCTTTGGCCAGGAGATG	ACT
rs753050	AGCACATAACACAGCATGGC	ACT
rs729647	GGTTGACGTCAACACAGGC	ACT
rs8404	CGAGACTACCAGGAGAGCCC	ACG
rs1044639	CATCCATCCAACCTGGCTC	CGT
rs2034453	AAACTGAGAATGTTGATGGACA	ACT
rs1904528	TCACATTGCTCTGCACTTTTG	ACG

The MassEXTEND™ reaction was performed in a total volume of 9 μl, with the addition of 1× ThermoSequenase buffer, 0.576 units of ThermoSequenase (Amersham Pharmacia), 600 nM MassEXTEND™ primer, 2 mM of ddATP and/or ddCTP and/or ddGTP and/or ddTTP, and 2 mM of dATP or dCTP or dGTP or dTTP. The deoxy nucleotide (dNTP) used in the assay normally was complementary to the nucleotide at the polymorphic site in the amplicon. Samples were incubated at 94° C. for 2 minutes, followed by 55 cycles of 5 seconds at 94° C., 5 seconds at 52° C., and 5 seconds at 72° C.

Following incubation, samples were desalted by adding 16 μl of water (total reaction volume was 25 μl), 3 mg of SpectroCLEAN™ sample cleaning beads (Sequenom, Inc.) and allowed to incubate for 3 minutes with rotation. Samples were then robotically dispensed using a piezoelectric dispensing device (SpectroJET™ (Sequenom, Inc.)) onto either 96-spot or 384-spot silicon chips containing a matrix that crystallized each sample (SpectroCHIP™ (Sequenom, Inc.)). Subsequently, MALDI-TOF mass spectrometry (Biflex and Autoflex MALDI-TOF mass spectrometers (Bruker Daltonics) can be used) and SpectroTYPER RT™ software (Sequenom, Inc.) were used to analyze and interpret the SNP genotype for each sample.

Genetic Analysis

The minor allelic frequencies for the polymorphisms set forth in Table 3 were verified as being 10% or greater using the extension assay described above in a group of samples isolated from 92 individuals originating from the state of Utah in the United States, Venezuela and France (Coriell cell repositories).

Genotyping results for the allelic variant set forth in Table 3 are shown for female pools in Table 6 and for male pools in Table 8. In Table 6, “F case” and “F control” refer to female case and female control groups, and in Table 7, “M case” and “M control” refer to male case and male control groups.

TABLE 6
Female Genotyping Results
	SNP			p-	Odds
	Reference	F case	F control	value	Ratio
	rs1360457	C = 0.869	C = 0.903	0.089	0.71
		T = 0.131	T = 0.097
	rs753050	A = 0.270	A = 0.210	0.021	0.71
		G = 0.730	G = 0.790
	rs729647	A = 0.578	A = 0.620	0.187	1.19
		G = 0.422	G = 0.380
	rs8404	C = 0.144	C = 0.094	0.016	0.62
		T = 0.856	T = 0.906
	rs1044639	A = 0.614	A = 0.528	0.006	1.42
		C = 0.386	C = 0.472
	rs2034453	G = 0.854	G = 0.901	0.023	0.64
		A = 0.146	A = 0.099
	rs1904528	T = 0.771	T = 0.838	0.008	0.65
		C = 0.229	C = 0.162

TABLE 7
Male Genotyping Results
	SNP			p-	Odds
	Reference	M case	M control	value	Ratio
	rs1360457	C = 0.876	C = 0.917	0.042	0.66
		T = 0.124	T = 0.083
	rs753050	A = 0.270	A = 0.190	0.009	0.66
		G = 0.730	G = 0.810
	rs729647	A = 0.543	A = 0.640	0.004	1.48
		G = 0.457	G = 0.360
	rs8404	C = 0.136	C = 0.098	0.071	0.69
		T = 0.864	T = 0.902
	rs1044639	A = 0.611	A = 0.551	0.072	1.28
		C = 0.389	C = 0.449
	rs2034453	G = 0.896	G = 0.890	0.767	1.07
		A = 0.104	A = 0.110
	rs1904528	T = 0.790	T = 0.822	0.396	0.82
		C = 0.210	C = 0.178

The single marker alleles set forth in Table 3 were considered validated, since the genotyping data for the females, males or both pools were significantly associated with melanoma, and because the genotyping results agreed with the original allelotyping results. Particularly significant associations with melanoma are indicated by a calculated p-value of less than 0.05 for genotype results, which are set forth in bold text.

The odds ratios were calculated for the alleles at each SNP and the results are shown in Tables 6 and 7. An odds ratio is an unbiased estimate of relative risk which can be obtained from most case-control studies. Relative risk (RR) is an estimate of the likelihood of disease in the exposed group (susceptibility allele or genotype carriers) compared to the unexposed group (not carriers). It can be calculated by the following equation: RR═I_A/I_a

• • I_A is the incidence of disease in the A carriers and I_a is the incidence of disease in the non-carriers.
  • RR>1 indicates the A allele increases disease susceptibility.
  • RR<1 indicates the a allele increases disease susceptibility. For example, RR=1.5 indicates that carriers of the A allele have 1.5 times the risk of disease than non-carriers, i.e., 50% more likely to get the disease.

Case-control studies do not allow the direct estimation of I_A and I_a, therefore relative risk cannot be directly estimated. However, the odds ratio (OR) can be calculated using the following equation: OR=(n_DAn_da)/(n_dAn_Da)=p_DA(1−p_dA)/p_dA(1−p_DA), or OR=((case f)/(1−case f))/((control f)/(1−control f)), where f=susceptibility allele frequency.

An odds ratio can be interpreted in the same way a relative risk is interpreted and can be directly estimated using the data from case-control studies, i.e., case and control allele frequencies. The higher the odds ratio value, the larger the effect that particular allele has on the development of melanoma, thus possessing that particular allele translates to having a higher risk of developing melanoma.

NID2 Non-Synonomous SNP

In addition, a non-synonomous, coding SNP (rs3742536) located at amino acid position 656 (P656S) of NID2 was genotyped and found to be significantly associated with the occurrence of melanoma. This SNP (rs3742536) was genotyped as described in Examples 1 and 2 herein using the following PCR primers, extend primer and termination mix: forward primer—ACGTTGGATGAGACCAACATTCAAGGCCAG; reverse primer—ACGTTGGATGAGTGGTACAGCTCCTTGTAG; extend primer—GGCTGTGAAATTTGCTG; and termination mix-ACT. The genotyping results for female (F) and male (M) cases and controls are shown in Table 8.

TABLE 8
Genotpying Results
	Chromosome						Odds
Rs number	Position	Sex	Alleles	Case AF	Control AF	p-Value	Ratio
rs3742536	50497467*	Male	C/T	T = 0.261	T = 0.192	0.0144	0.67
				C = 0.739	C = 0.808
		Female		T = 0.257	T = 0.205	0.0561	0.75
				C = 0.743	C = 0.795
*based on NCBI's Build 34

Example 3

Samples and Pooling Strategies for the Replication Cohort

The single marker alleles set forth in Table 3 were genotyped again in a replication cohort to further validate their association with melanoma. Like the original study population described in Examples 1 and 2, the replication cohort consisted of individuals diagnosed with melanoma (cases) and individuals free of melanoma (controls). The case and control samples were selected and genotyped as described below.

Sample Selection

Blood samples were collected from individuals diagnosed with melanoma, which were referred to case samples. Also, blood samples were collected from individuals not diagnosed with me lanoma or a history of melanoma; these samples served as gender and age-matched controls.

DNA Extraction from Blood Samples

Blood samples for DNA preparation were taken in 5 EDTA tubes. If it was not possible to get a blood sample from a patient, a sample from the cheek mucosa was taken. Red blood cells were lysed to facilitate their separation from the white blood cells. The white cells were pelleted and lysed to release the DNA. Lysis was done in the presence of a DNA preservative using an anionic detergent to solubilize the cellular components. Contaminating RNA was removed by treatment with an RNA digesting enzyme. Cytoplasmic and nuclear proteins were removed by salt precipitation.

Genomic DNA was then isolated by precipitation with alcohol (2-propanol and then ethanol) and rehydrated in water. The DNA was transferred to 2-ml tubes and stored at 4° C. for short-term storage and at −70° C. for long-term storage.

Pooling Strategies

Samples were placed into one of four groups based on disease status. The four groups were female case samples, female control samples, male case samples, and male control samples. A select set of samples from each group were utilized to generate pools, and one pool was created for each group.

Replication samples were obtained from QIMR (Queensland Institute of Medical Research) through Nick Martin. All samples are of Australian descent. Sample sources were as follows: a.) Queensland Familial Melanoma Study-702 cutaneous malignant melanoma cases plus 46 unaffected relatives; and b.) Twin mole study-2367 controls, consisting of adolescent twins and siblings closest in age that had nevi counted and other skin and pigmentary phenotypes assessed. The subjects available for replication from Australia included 702 mostly unrelated melanoma cases from the Queensland Familial Melanoma study and 2367 controls from the Twin Mole study with subjects organized into pedigrees with up to eight unaffected individuals.

To facilitate a direct comparison with the discovery study design and subsequent meta analyses, we selected a subset of the Australian sample to produce a research data set of unrelated cases and controls. For cases, this was done by selecting the proband from all families within the familial melanoma study. For controls, this was accomplished by selecting the pedigree founders from the twin study, usually the father and mother of the collected twins. The resulting data set consisted of 376 female and 300 male cases, and 640 female and 515 male controls.

Example 4

Association of Polymorphic Variants with Melanoma in the Replication Cohort

The associated SNPs from the initial scan were re-validated by genotyping the associated SNP across the replication cohort described in Example 3. The results of the genotyping were then analyzed, allele frequencies for each group were calculated from the individual genotyping results, and a p-value was calculated to determine whether the case and control groups had statistically significantly differences in allele frequencies for a particular SNP. The replication genotyping results were considered significant with a calculated p-value of less than 0.05 for genotype results, which are set forth in bold text. See Tables 8 and 9 herein.

Assay for Verifying Allelotyping, and Genotyping SNPs

Genotyping of the replication cohort was performed using the same methods used for the original genotyping, as described herein. A MassARRAY™ system (Sequenom, Inc.) was utilized to perform SNP genotyping in a high-throughput fashion. This genotyping platform was complemented by a homogeneous, single-tube assay method (hME™ or homogeneous MassEXTEND™ (Sequenom, Inc.)) in which two genotyping primers anneal to and amplify a genomic target surrounding a polymorphic site of interest. A third primer (the MassEXTEND™ primer), which is complementary to the amplified target up to but not including the polymorphism, was then enzymatically extended one or a few bases through the polymorphic site and then terminated.

For each polymorphism, SpectroDESIGNER™ software (Sequenom, Inc.) was used to generate a set of PCR primers and a MassEXTEND™ primer which where used to genotype the polymorphism. Other primer design software could be used or one of ordinary skill in the art could manually design primers based on his or her knowledge of the relevant factors and considerations in designing such primers. Table 4 shows PCR primers and Table 5 shows extension probes used for analyzing (e.g., genotyping) polymorphisms. The initial PCR amplification reaction was performed in a 5 μl total volume containing 1×PCR buffer with 1.5 mM MgCl₂ (Qiagen), 200 μM each of dATP, dGTP, dCTP, dTTP (Gibco-BRL), 2.5 ng of genomic DNA, 0.1 units of HotStar DNA polymerase (Qiagen), and 200 nM each of forward and reverse PCR primers specific for the polymorphic region of interest.

Samples were incubated at 95° C. for 15 minutes, followed by 45 cycles of 95° C. for 20 seconds, 56° C. for 30 seconds, and 72° C. for 1 minute, finishing with a 3 minute final extension at 72° C. Following amplification, shrimp alkaline phosphatase (SAP) (0.3 units in a 2 μl volume) (Amersham Pharmacia) was added to each reaction (total reaction volume was 7 μl) to remove any residual dNTPs that were not consumed in the PCR step. Samples were incubated for 20 minutes at 37° C., followed by 5 minutes at 85° C. to denature the SAP.

Once the SAP reaction was complete, a primer extension reaction was initiated by adding a polymorphism-specific MassEXTEND™ primer cocktail to each sample. Each MassEXTEND™ cocktail included a specific combination of dideoxynucleotides (ddNTPs) and deoxynucleotides (dNTPs) used to distinguish polymorphic alleles from one another. Methods for verifying, allelotyping and genotyping SNPs are disclosed, for example, in U.S. Pat. No. 6,258,538, the content of which is hereby incorporated by reference. In Table 5, ddNTPs are shown and the fourth nucleotide not shown is the dNTP.

The MassEXTEND™ reaction was performed in a total volume of 9 μl, with the addition of 1× ThermoSequenase buffer, 0.576 units of ThermoSequenase (Amersham Pharmacia), 600 nM MassEXTEND™ primer, 2 mM of ddATP and/or ddCTP and/or ddGTP and/or ddTTP, and 2 mM of dATP or dCTP or dGTP or dTTP. The deoxy nucleotide (dNTP) used in the assay normally was complementary to the nucleotide at the polymorphic site in the amplicon. Samples were incubated at 94° C. for 2 minutes, followed by 55 cycles of 5 seconds at 94° C., 5 seconds at 52° C., and 5 seconds at 72° C.

Following incubation, samples were desalted by adding 16 μl of water (total reaction volume was 25 μl), 3 mg of SpectroCLEAN™ sample cleaning beads (Sequenom, Inc.) and allowed to incubate for 3 minutes with rotation. Samples were then robotically dispensed using a piezoelectric dispensing device (SpectroJET™ (Sequenom, Inc.)) onto either 96-spot or 384-spot silicon chips containing a matrix that crystallized each sample (SpectroCHIP™ (Sequenom, Inc.)). Subsequently, MALDI-TOF mass spectrometry (Biflex and Autoflex MALDI-TOF mass spectrometers (Bruker Daltonics) can be used) and SpectroTYPER RT™ software (Sequenom, Inc.) were used to analyze and interpret the SNP genotype for each sample.

Genetic Analysis

The minor allelic frequencies for the polymorphisms set forth in Table 3 were verified as being 10% or greater using the extension assay described above in a group of samples isolated from 92 individuals originating from the state of Utah in the United States, Venezuela and France (Coriell cell repositories).

Replication genotyping results are shown for females and males in Table 9. P-values and odds ratios are provided in Table 10.

TABLE 9
Female and Male Replication Genotyping Results
	Allele	Allele
	frequency-females	frequency-males
dbSNP			Con-			Con-
rs#	Gene	Case	trol	Delta	Case	trol	Delta
rs8404	CDK10	0.87	0.91	−0.043	0.88	0.91	−0.029
rs1044639	PCLO	0.60	0.57	0.031	0.61	0.56	0.042
rs2034453	FPGT/	0.85	87.00	−0.022	0.84	0.87	−0.026
	TNNI3K
	(CARK)
rs1904528	REPS2	0.78	0.79	−0.005	0.77	0.82	−0.051

TABLE 10
Female and Male Replication Genotyping Analysis
	Replication F	Replication M	Summary
dbSNP		p-		p-		p-
rs#	Gene	value	OR	value	OR	value	OR
rs8404	CDK10	0.002	0.65	0.054	0.72	0.000004	0.67
rs1044639	PCLO	0.180	1.13	0.100	1.19	0.000290	1.23
rs2034453	FPGT/	0.170	0.83	0.150	0.81	0.014000	0.82
	TNNI3K
	(CARK)
rs1904528	REPS2	0.800	0.97	0.076	0.73	0.033000	0.80

Meta analyses, combining the results of the German discovery sample and the Australian replication sample, were carried out using a random effects (DerSimonian-Laird) procedure. Statistically significant associations with melanoma are indicated by a calculated p-value of less than 0.05 for genotype results, which are set forth in bold text.

The absence of a statistically significant association in the replication cohort should not be interpreted as minimizing the value of the original finding. There are many reasons why a biologically derived association identified in a sample from one population would not replicate in a sample from another population. The most important reason is differences in population history. Due to bottlenecks and founder effects, there may be common disease predisposing alleles present in one population that are relatively rare in another, leading to a lack of association in the candidate region. Also, because common diseases such as melanoma are the result of susceptibilities in many genes and many environmental risk factors, differences in population-specific genetic and environmental backgrounds could mask the effects of a biologically relevant allele.

Example 5

NRP1 Proximal SNPs

It has been discovered that a polymorphic variation in a gene encoding the receptor neuropilin 1 (NRP1 is associated with the occurrence of melanoma.

Ninety-five allelic variants located within or nearby the target gene were identified and subsequently allelotyped in melanoma case and control sample sets as described in Examples 1 and 2. The polymorphic variants are set forth in Table 11. The chromosome position provided in column four of Table 11 is based on Genome “Build 34” of NCBI's GenBank and dbSNP 119.

TABLE 11
					Allele
			Position		Present
	Chromo-	Chromosome	in SEQ	Allele	in SEQ	IUPAC
dbSNP rs#	some	Position	ID NO. 1	Variants	ID NO: 1	Code
rs7910405	10	33590041	2,141	T/C	T	Y
rs5784331	10	33590861	2,961	—/A	A	N
rs6481845	10	33596683	8,783	T/C	T	Y
rs2065364	10	33598008	10,108	C/T	T	Y
rs10643659	10	33599549	11,649	—/GTTT	G	N
rs7896887	10	33603031	15,131	A/G	G	R
rs7086456	10	33606418	18,518	C/T	C	Y
rs6481846	10	33606937	19,037	G/A	G	R
rs7475391	10	33606955	19,055	C/T	T	Y
rs7477281	10	33606956	19,056	C/T	C	Y
rs7475393	10	33606959	19,059	C/T	T	Y
rs7475394	10	33606966	19,066	C/T	T	Y
rs7477282	10	33606970	19,070	C/T	C	Y
rs7475396	10	33606978	19,078	C/T	T	Y
rs2768420	10	33609638	21,738	G/A	G	R
rs9418057	10	33612486	24,586	C/T	T	Y
rs7070290	10	33615210	27,310	G/A	G	R
rs1360457	10	33620935	33,035	T/C	A	R
rs1411924	10	33623568	35,668	G/A	C	Y
rs5784335	10	33626177	38,277	T/—	T	N
rs2776925	10	33718511	130,611	C/T	A	R
rs2776924	10	33718757	130,857	G/C	T	S
rs1952983	10	33719174	131,274	A/C	T	K
rs869636	10	33722278	134,378	C/T	A	R
rs869637	10	33722444	134,544	C/T	G	R
rs2804470	10	33723869	135,969	G/A	G	R
rs2776928	10	33724644	136,744	T/C	T	Y
rs999966	10	33724924	137,024	C/T	A	R
rs2804475	10	33724926	137,026	C/G	G	S
rs4934858	10	33728527	140,627	C/T	C	Y
rs4934863	10	33729317	141,417	C/T	T	Y
rs4934864	10	33729327	141,427	C/T	G	R
rs1331326	10	33730129	142,229	G/A	C	Y
rs1331325	10	33730408	142,508	A/G	T	Y
rs4934871	10	33733328	145,428	G/A	G	R
rs4277057	10	33736929	149,029	G/T	T	K
rs2776930	10	33738120	150,220	C/T	A	R
rs1331324	10	33739704	151,804	G/C	G	S
rs2776932	10	33742645	154,745	C/T	G	R
rs4934896	10	33743848	155,948	A/G	A	R
rs2776933	10	33745084	157,184	T/C	C	Y
rs4934901	10	33746285	158,385	A/T	T	W
rs1015300	10	33747483	159,583	G/C	A	S
rs2776934	10	33750081	162,181	G/C	G	S
rs2776935	10	33750537	162,637	G/A	G	R
rs2776936	10	33751120	163,220	C/T	T	Y
rs2804491	10	33751126	163,226	A/C	A	M
rs2804492	10	33752285	164,385	T/C	T	Y
rs2804493	10	33755915	168,015	A/G	G	R
rs2776937	10	33756428	168,528	A/G	A	R
rs2804494	10	33759655	171,755	G/C	T	S
rs4934914	10	33761218	173,318	G/A	G	R
rs2776922	10	33762121	174,221	T/C	C	Y
rs2804495	10	33762739	174,839	G/T	C	M
rs2804496	10	33764040	176,140	T/C	A	R
rs4934597	10	33764960	177,060	T/C	T	Y
rs2804497	10	33766276	178,376	G/T	A	M
rs2804498	10	33770946	183,046	T/C	A	R
rs2026319	10	33771741	183,841	G/C	C	S
rs1888684	10	33773216	185,316	T/C	G	R
rs3750733	10	33773490	185,590	A/G	C	Y
rs4934927	10	33778301	190,401	G/C	G	S
rs2776946	10	33782804	194,904	T/C	T	Y
rs4934599	10	33784201	196,301	T/C	T	Y
rs4934934	10	33785140	197,240	A/G	A	R
rs2776944	10	33785311	197,411	T/G	T	K
rs2776943	10	33786453	198,553	C/T	A	R
rs2804886	10	33787179	199,279	G/A	G	R
rs2804900	10	33787641	199,741	G/A	T	Y
rs2804902	10	33787672	199,772	T/C	C	Y
rs2768397	10	33788724	200,824	G/C	C	S
rs2768399	10	33788911	201,011	A/G	A	R
rs2776941	10	33790186	202,286	C/G	A	S
rs2804888	10	33791746	203,846	G/A	A	R
rs2804499	10	33791760	203,860	C/G	T	S
rs2804889	10	33792103	204,203	G/A	G	R
rs2804891	10	33792647	204,747	G/A	C	Y
rs2776940	10	33794228	206,328	A/T	A	W
rs2804897	10	33794781	206,881	C/T	C	Y
rs2804896	10	33795259	207,359	T/C	C	Y
rs2776939	10	33795324	207,424	C/T	C	Y
rs2804894	10	33797330	209,430	T/C	C	Y
rs2804501	10	33798562	210,662	A/T	C	W
rs2183715	10	33799002	211,102	A/C	T	K
rs2254822	10	33799071	211,171	G/A	T	Y
rs2150686	10	33799262	211,362	G/A	A	R
rs2804893	10	33799778	211,878	T/C	A	R
rs2804502	10	33800099	212,199	T/C	A	R
rs2804892	10	33800318	212,418	T/C	C	Y
rs2183714	10	33803309	215,409	G/A	T	Y
rs2804503	10	33804955	217,055	C/T	T	Y
rs1320485	10	33806274	218,374	T/C	G	R
rs4934603	10	33808882	220,982	A/G	T	Y
rs2804890	10	33808922	221,022	C/T	A	R
rs1854145	10	33809260	221,360	A/G	G	R

Assay for Verifying and Allelotyping SNPs

The methods used to verify and allelotype the seventy-six proximal SNPs of Table 11 are the same methods described in Examples 1 and 2 herein. The primers used in these assays are provided in Table 12 and Table 13, respectively.

	TABLE 12
	dbSNP rs #	Forward PCR Primer	Reverse PCR Primer
	rs6481844	GGAGAAAACCAAGATGGCAC	CATAATTGGCAACTCCCCAG
	rs7910405	GAGTCAGGACTTGCAAACAG	CAGACTGAGAACCAACTTAG
	rs5784331	GAATTGGGAGGCATGCTTTG	AGCAGATTTACTCCCTTCCC
	rs6481845	AATGCCATCAACTTGGGCTC	CAGCAGCTACCAAGCAGTAT
	rs2065364	AATCTTGCTGGTGCTCACTC	CAGAAGGAGACACTGTCTCA
	rs10643659	TTATTACGTAAGTTCCTTCC	CAGTCTACCTCTGAAAATAG
	rs7896887	CCTCTCCCACCACTGTTTTA	AAGTGCGGTGATAGGAAAGC
	rs7086456	CAGTCTACCTCTGAAAATAG	TTATTACGTAAGTTCCTTCC
	rs6481846	ATTGGAATCCCTCCTGGATC	TTTTGAACAGGGCACCACAG
	rs747539	TTTAGGAATGGAAATCCTGGG	CCTGGTTGTCAGGCTTTAAA
	rs747728	TTTATTACGTAAGTTCCTTCC	CAGTCTACCTCTGAAAATAG
	rs7475393	AAATAGCTCATGTACCCCAG	CCTGCCATAGAGCATATTAC
	rs7475394	TTATTACGTAAGTTCCTTCC	CAGTCTACCTCTGAAAATAG
	rs7477282	TTATTACGTAAGTTCCTTCC	CAGTCTACCTCTGAAAATAG
	rs7475396	TTATTACGTAAGTTCCTTCC	CAGTCTACCTCTGAAAATAG
	rs2768420	TTTCCTTGACAGATAACTGC	GCAGCTAAAAGACATCATTG
	rs9418057	TTATTACGTAAGTTCCTTCC	CAGTCTACCTCTGAAAATAG
	rs7070290	GTGGCACTAGTTTTCAGAAG	GCCCTATGAAAACCAGATTC
	rs1360457	CAGGATTATCTGACAGGAGG	TATTTTCCTTTCCCACCAGC
	rs1411924	TCCTTCCTCTCCTCCTTCTC	CCTACTTTTCCTTCAAACAC
	rs5784335	TGATTCACATTCTCCTCCCC	TAGGCATGAGCACTTTGTGG
	rs2776925	ACCACTCATGTCTGCCTGCT	TGAAGGATCTTTACTCAGGC
	rs2776924	CCCCAAGAATCTTGCACTTC	AGGTCTTCAAGACCTGTTCC
	rs1952983	GCTGGCACTCATTTTCTCTC	AGTTCCACATAGCTGGAGAG
	rs869636	CACACTCACTGAAGCGTTTG	CCAAATAACATGCTGATCGC
	rs869637	AAGTGTTCTTCTCCCACAGC	CCTTTAACCCTTACAGAGCC
	rs2804470	GGTGCAGCTAAAGAGAAACG	TGGCCGAGGGTTAATTTTTG
	rs2776928	GACAGAAAGATTTGTGACGC	CATTTGACAGCTGAGATCCC
	rs999966	GCAGTGGGCACTAACCTAAG	GGTTGCGGTTATCTTAGCAG
	rs2804475	TGTGGCATCATTTGTCTTCC	CATCATTCCCCCAGTTCTAG
	rs4934858	GATCATTGGTGGAAACAGGG	CCACCCATCATTACAATCGC
	rs4934863	GCTTCTATTAGGGTGTTGGC	CAGTGCTCACTCAGTTAGTC
	rs4934864	AGTCTCACCAAGACCTTCTG	CACCTAGGGATTTATAGACG
	rs1331326	TTTAAACATGGTCTCGTGGC	CTACAGTGGCAAAGAACACG
	rs1331325	CCTTCTTCATTCATCAGGGC	AAAACTGCCATTCCTCCCAC
	rs4934871	GGAATATAAGTCCTGCAGCC	TGCACATATAGACGTATCAC
	rs4277057	ACACCCTGCATTTTCTCTTG	GCAAATGTGCTAAGGCATCG
	rs2776930	CCTCTTCCAAAAGTAAGCCC	GGAAGAAACCAGTCCAAGAG
	rs1331324	GTGCTTATTACCCGAGTGAC	CCTGTACGTGTACAGGTTTG
	rs2776932	CTGCAAGAACCTGAACTCTG	AGAAATCGAGGTGTTGGCTG
	rs4934896	ACAGATATGCTGCAGTGACC	ATTACCCAAGTAGGCTTCCC
	rs2776933	CTGAGTATCTGGGACTACAG	TGGTTAACACGGTGAAACCC
	rs4934901	GCACTAGTCCAGCATTTTCC	ACTTTGCTTCATACCATGGA
	rs1015300	CCTCTTCTGTAATCTCTAGTG	AACGGACAAGTACTCTAAGC
	rs2776934	CTCCCTTTCTTGAGGTTGAC	CAAACACGAATCTAGGAGCC
	rs2776935	AATACTCTCACCACCACCAC	CCCAGCACAAATAAGTGCTC
	rs2776936	CAATCCCAGGGGATTATAGC	TGTTTACCGATGCTCGTACC
	rs2804491	AACTCCTGACCTCAAGTGAC	AAATGAACTCCTCTTGGCCG
	rs2804492	ATGCCTGAAATCCCAGCTAC	AGTGGCTCAATCTTGGCTCC
	rs2804493	TCAGCTAATTCCCAGCATTC	GGAGTTGACAGTTCAAATCCT
	rs2776937	GAAATCCTGTGGTAGGAATC	GACATCTCATTTTCTAGGTG
	rs2804494	CCTAGACCTTAGTCTTACCC	TCAGAAGACCACATTCTCAG
	rs4934914	TAAGTCCTGCAGCCACTTTG	GCATACACAAATATATGCAC
	rs2776922	TTGAAATCCTTTCCACTGGC	GTTCTGTTGCCTTCATGCTC
	rs2804495	GGAAGATCTTTGAGAGTTAGC	AGGAACAGCCACATTTTGAC
	rs2804496	AAAGAAGAAGGCCCCAACAC	TTCTTGGCCCTGATTTCTCC
	rs4934597	TTCTTGACCTCGTGATCCAC	AATTAACCCTCGGCCAGGTG
	rs2804497	AACTCCCTCCTTCCCTTAAC	CTCAGGGTGTATTTTACACG
	rs2804498	AGCACTTAAGACAGCCACTC	GTGGCCAGATTCTCTGAATG
	rs2026319	AATTGGCATGCTGATCTGGG	GGGCTTTTCCTTACCTCTGT
	rs1888684	AACAGCCTTTCAGCTTTGGC	TTGTCCCAACTGAGGCTTTG
	rs3750733	CTGCCTGTCACTTACCGTTG	GCTCCTCTGCGCCGTGCTC
	rs4934927	TTTATTCATGGCAGAAGGCG	ATAAAGTGCAGTACCTCCCC
	rs2776946	CCCATAAAGGAAGCAGAAGC	TTTGTCCCCTATCCTCTCTC
	rs4934599	TTTTCGAGACGGAGTCTTGC	GAGGCGGAGATTACAGTAAG
	rs4934934	GGATGAAATGAGAATGACCC	GAGGAGTCGACTGTTGAATG
	rs2776944	CATAAGGCCATTCATGAGGG	GAAAGAGCTTGGGATCATGG
	rs2776943	GGAGTTGACAGTTCAAATCCT	TCAGCTAATTCCCAGCATTC
	rs2804886	GAAAAGAACATTATTTGCAGC	CTCCCTTTTTCTTATTAGTC
	rs2804900	CTAATTTCACCTGTAGGATG	TTCACATGGTGAAAGCAGGG
	rs2804902	AAGTTTGAGAACCACTGGGC	CATGAATCCCTCTGCAACTC
	rs2768397	CACACCAGAGCTCTTTAATC	GAGAGATTGAACAGAGCCAG
	rs2768399	CAAGATGAGATTTGGGTGGG	TGGACTGGTTTCTTCCTCAC
	rs277694	TTGGTTTATGGTCTTGGCGTC	GGGAAGAAAAGACGACCTAC
	rs2804888	TAACATGTCCACAGCCTTCC	GGATGGTTTCACTACTGTATG
	rs2804499	TGGCTCACTCGCAAACATTG	ATGTTGGCCAGGCTGGTTTC
	rs2804889	ACACCCAACTCTCTATGAGC	AGGTCCTGACCATGCATGAG
	rs2804891	GTGAACAAAAGTAGACTCCC	GCACTCTCTGGGATAATTTC
	rs2776940	TACATGAAGGCAATCGCACC	TGGTGGTGGATAAGCCAATG
	rs2804897	ATCTGGTCAGGTTTGGTCTC	CAAATAGAACTGACATCTGC
	rs2804896	AAGACCCTCTTCCTGGTTTG	TGCTTTCTCTCTCTTCTCCC
	rs2776939	TTTCCAGCTTGCAGAACCTC	TAGAGCATGATCTAGGTCCC
	rs2804894	CATTAATATGTGGCCATGGG	AGGGGTACACAATTCAATCC
	rs2804501	AGTTCGTTGCACCTTGAGAG	GACACTACTAACTGCCCTAG
	rs2183715	ATGGATTGAGCCACACTCTC	TGTCTCTAGACGTGTGTTGG
	rs2254822	TTCAGTGAAAGTTGCCTGTG	AGAGGTGCAATAACTGGTGG
	rs2150686	TTCAGTGAAAGTTGCCTGTG	AGAGGTGCAATAACTGGTGG
	rs2804893	ATACAAAAATTAGCCGGGCG	CTCCTGGGTTCAAGAGATTC
	rs2804502	AATGTGGCAGCATTTCAGGC	CTGGGCTGCCTATATTGTTC
	rs2804892	TAATTTCCTCCATCCCTCCC	CCCATGAAAGACTTAACCTTC
	rs2183714	TTTAAACATGGTCTCGTGGC	CTACAGTGGCAAAGAACACG
	rs2804503	GTCCTCTCTCTGTTTTAGGC	AATCTGTTTGCTTACTTTTC
	rs1320485	ATGCCTGAAATCCCAGCTAC	AGTGGCTCAATCTTGGCTCC
	rs4934603	CTCTCCTCTGTGTAACCAAC	GTTACAAGTATGCGATCTTCC
	rs2804890	ACTTAAGTGGCATCAGGTAG	ATCACAAATTGGAAGCCAAC
	rs1854145	GGATCCTAATTTGCGCTGAC	TCTGGGCAGTAAGTTTCAGG

	TABLE 13
	Term
	dbSNP rs #	Extend Primer	Mix
	rs6481844	AACAACTGGAAAACCTTGGCT	ACT
	rs7910405	GATGTTCAGTGCTTGCTTTGC	ACT
	rs5784331	ATGATTCCAGGGGATTTTTTTTT	ACG
	rs6481845	AGAAGGTGAATGCTATAACTAAA	ACT
	rs2065364	TCTCCTCCCCATGTGCT	ACG
	rs10643659	CATATTATTTCAGAAATTATGGTTG	ACT
	rs7896887	CTGGGACTACAGACGCCC	ACT
	rs7086456	TCATGTACCCCAGTAATGTATA	ACG
	rs6481846	GAGAGAAGGAAGGAAGGAAAA	ACG
	rs7475391	TTCGTTTTCCTTCCTTCCTTC	ACG
	rs7477281	TCGTTTTCCTTCCTTCCTTCT	ACG
	rs7475393	TTTTCCTTCCTTCCTTCTCTC	ACG
	rs7475394	CCTTCCTTCTCTCTCTCTCT	ACG
	rs7477282	TCCTTCTCTCTCTCTCTTTCT	ACG
	rs7475396	TCTCTCTCTTTCTCTCTCTCT	ACG
	rs2768420	CACCATGAGATGCAGGA	ACG
	rs9418057	TGGTGCTCACTCTTTGCGG	ACG
	rs7070290	GATGGAGTTTAAAAGCACAAAG	ACG
	rs1360457	CAGCTTTGGCCAGGAGATG	ACT
	rs1411924	ATTTATAATCTACATTGTACACAC	ACG
	rs5784335	TTCCATGTTCATAATTTTTTTTTT	ACT
	rs2776925	CCAGTGGTGTGAGCTTC	ACG
	rs2776924	GAGGTTGACTCATGATTT	ACT
	rs1952983	CCTGATTGAAGCAAAACCAGAA	ACT
	rs869636	TGTTCAACAGACCCTTC	ACG
	rs869637	GTAATCTCTAGTGTTTATTGAAAG	ACG
	rs2804470	TTGCAGCATTTCCCTAA	ACG
	rs2776928	GTGGATCCTAATGATCAC	ACT
	rs999966	GGAGAACTGCTTGAACC	ACG
	rs2804475	AGAACTGCTTGAACCCG	ACT
	rs4934858	TGGGATTTCGTTACCTAA	ACG
	rs4934863	CAACCTGAGGATGTATAGAA	ACG
	rs4934864	GGATGTATAGAATGCCTATATG	ACG
	rs1331326	TTCCTTGATCTCTTTCTTC	ACG
	rs1331325	TTGCGCTGACAAAAACC	ACT
	rs4934871	GAGATATGTAGGACCCC	ACG
	rs4277057	AGAGGGTAGTAAATCCTG	CGT
	rs2776930	TGCTATTACTACTTCTACCTAC	ACG
	rs1331324	GTGTGTGCACATCTCAA	ACT
	rs2776932	CGTAGTTCTTCGCCCCT	ACG
	rs4934896	ACCCCATCTAAACAAAAG	ACT
	rs2776933	TAGCCGGGCGTGGTGGT	ACT
	rs4934901	TGGGATCATGAATCCTAG	CGT
	rs1015300	CTAAACCCTTGTGACATG	ACT
	rs2776934	TTTTACTGACTCTTCAAGTG	ACT
	rs2776935	TATCTTCATCTGCAGCC	ACG
	rs2776936	GACAGTTCAAATCCTTTTTTT	ACG
	rs280449	TTGTCTAGTATTTCTAAACACTG	ACT
	rs2804492	CTTAGTCTTACCCATGAAC	ACT
	rs2804493	GGAGTTGCCAATTATGTATAAG	ACT
	rs2776937	GGTGGGGATAAGGAGCT	ACT
	rs2804494	GGGTGTTGGAGTGGGTG	ACT
	rs4934914	CCCTCATTCATACAGTTT	ACG
	rs2776922	TTTGTGACGCAGCAACT	ACT
	rs2804495	GGTTGATTGGCCTGTAT	CGT
	rs2804496	AGGCAGGCATCACTTGA	ACT
	rs4934597	TTTTTCCTAACTCAGTGC	ACT
	rs2804497	GTATAGTCAACTTCCACC	CGT
	rs2804498	TCCATCATAAAATGTGACAAT	ACT
	rs2026319	TGACTTCTGAGAAAGTGA	ACT
	rs1888684	ATGCTGATCTGGGAAGGTAG	ACT
	rs3750733	TTACCGTTGCGAAAAGC	ACT
	rs4934927	TGAATCTTTGGTAACACC	ACT
	rs2776946	GTGCTAGGATTACAGGC	ACT
	rs4934599	CACAGAGCTCACCCACC	ACT
	rs4934934	AGGAAAAAGGCTTATCAAG	ACT
	rs2776944	ACTTGACCTAGCACCAG	ACT
	rs2776943	GGCTAAAAAGTGTGTCAA	ACG
	rs2804886	GATGTGCTCAGCTCTTA	ACG
	rs2804900	CTGTAATCTCCGCCTCC	ACG
	rs2804902	GGCTGGAGTGCAGTGGC	ACT
	rs2768397	CTGGCTAGCCTTTTAGAA	ACT
	rs2768399	ACAAAAACCACCATCAAA	ACT
	rs2776941	ATGCCAACTGAGAAGGA	ACT
	rs2804888	CTCCCTTCTGGGAGGAT	ACG
	rs2804499	CCCAATCCTCCCAGAAG	ACT
	rs2804889	GGTCTCCAAATGAGTGG	ACG
	rs2804891	GAAACAGGGATGGAGATA	ACG
	rs2776940	CAGCAACAGGTCTCACC	CGT
	rs2804897	GAGAGGAATGGAGAAAAA	ACG
	rs2804896	GTACTGGGATTACAGGC	ACT
	rs2776939	AAACGTCAGAGCCAGCC	ACG
	rs2804894	TCTCACTGGGGACCCAC	ACT
	rs2804501	GCATTTTCCTCTCTCTG	CGT
	rs2183715	GATAGAGGTCAAGGAGAG	ACT
	rs2254822	GTAAGCCCTACCTATGC	ACG
	rs2150686	GTTGCCTGTGTTCTGGA	ACG
	rs2804893	GCAATTCTCCTGCCTCA	ACT
	rs2804502	GTGAATATGGAAAAAACCAA	ACT
	rs2804892	TGCCATCTTCTCATTGT	ACT
	rs2183714	TTGTGTAGAATAGAGCCC	ACG
	rs2804503	TTGTCCTCTGTGCTAGA	ACG
	rs1320485	TGCTGGTGAGCAGGGAG	ACT
	rs4934603	GCAGAAGGCGAAGTGGT	ACT
	rs2804890	GTGCAGTACCTCCCCCC	ACG
	rs1854145	CTCATTTTCTCTCTATTCCC	ACT

Genetic Analysis

Allelotyping results are shown for female (F) and male (M) cases and controls in Table 14 and Table 15, respectively. Allele frequency is noted in the fourth and fifth columns for melanoma pools and control pools, respectively.

TABLE 14
Females
								Melanoma
	Chromo-	Chromosome		Female Case	Female Control	F	Odds	Associated
dbSNP rs#	some	Position	Alleles	AF	AF	p-Value	Ratio	Allele
rs6481844	10	33588137	T/C	T = 0.587	T = 0.612	0.440	1.110	C
				C = 0.412	C = 0.387
rs7910405	10	33590041	T/C	T = 0.926	T = 0.890	0.090	0.640	T
				C = 0.073	C = 0.109
rs5784331	10	33590861	—/A	— = 0.375	— = 0.386	0.725	1.049	A
				A = 0.624	A = 0.613
rs6481845	10	33596683	T/C	T = 0.329	T = 0.305	0.445	0.896	T
				C = 0.670	C = 0.694
rs2065364	10	33598008	A/G	A = 0.354	A = 0.396	0.192	1.197	G
				G = 0.645	G = 0.603
rs10643659	10	33599549	—/GTTT	— = 0.198	— = 0.125	0.006	0.582	—
				GTTT = 0.801	GTTT = 0.874
rs7896887	10	33603031	A/G	A = 0.631	A = 0.571	0.066	0.778	A
				G = 0.368	G = 0.428
rs7086456	10	33606418	C/T	C = 0.857	C = 0.853	0.870	0.965	C
				T = 0.142	T = 0.146
rs6481846	10	33606937	G/A	G = 0.849	G = 0.837	0.663	0.919	G
				A = 0.150	A = 0.162
rs7475391	10	33606955	C/T	C = 0.705	C = 0.608	0.014	0.647	C
				T = 0.294	T = 0.391
rs7477281	10	33606956	C/T	C = 0.291	C = 0.236	0.079	0.752	C
				T = 0.708	T = 0.763
rs7475393	10	33606959	C/T	C = 0.549	C = 0.486	0.159	0.777	C
				T = 0.450	T = 0.513
rs7475394	10	33606966	C/T	C = 0.729	C = 0.815	0.007	1.641	T
				T = 0.270	T = 0.184
rs7477282	10	33606970	C/T	C = 0.908	C = 0.899	0.738	0.903	C
				T = 0.091	T = 0.100
rs7475396	10	33606978	C/T	C = 0.209	C = 0.104	˜0.001	0.438	C
				T = 0.790	T = 0.895
rs2768420	10	33609638	T/C	T = 0.789	T = 0.791	0.925	1.015	C
				C = 0.210	C = 0.208
rs9418057	10	33612486	C/T	C = 0.865	C = 0.916	0.019	1.698	T
				T = 0.134	T = 0.083
rs7070290	10	33615210	G/A	G = 0.948	G = 0.941	0.725	0.879	G
				A = 0.051	A = 0.058
rs1360457	10	33620935	T/C	T = 0.278	T = 0.210	0.020	0.692	T
				C = 0.721	C = 0.789
rs1411924	10	33623568	G/A	G = 0.165	G = 0.126	0.110	0.729	G
				A = 0.834	A = 0.873
rs5784335	10	33626177	T/—	T = 0.219	T = 0.129	˜0.001	0.526	T
				— = 0.780	— = 0.870
rs2776925	10	33572278	C/T	C = 0.436	C = 0.452	0.608	1.071	T
				T = 0.563	T = 0.547
rs2776924	10	33572524	G/C	G = 0.755	G = 0.724	0.307	0.850	G
				C = 0.244	C = 0.275
rs1952983	10	33572941	A/C	A = 0.616	A = 0.553	0.081	0.771	A
				C = 0.383	C = 0.446
rs869636	10	33576045	C/T	C = 0.442	C = 0.444	0.949	1.009	T
				T = 0.557	T = 0.555
rs869637	10	33576211	C/T	C = 0.888	C = 0.914	0.225	1.338	T
				T = 0.111	T = 0.085
rs2804470	10	33577636	G/A	G = 0.181	G = 0.240	0.071	1.422	A
				A = 0.818	A = 0.759
rs2776928	10	33578411	T/C	T = 0.893	T = 0.920	0.177	1.385	C
				C = 0.106	C = 0.079
rs999966	10	33578691	C/T	C = 0.828	C = 0.828	0.995	1.001	T
				T = 0.171	T = 0.171
rs2804475	10	33578693	C/G	C = 0.035	C = 0.061	0.177	1.808	G
				G = 0.964	G = 0.938
rs4934858	10	33582294	C/T	C = 0.505	C = 0.525	0.552	1.084	T
				T = 0.494	T = 0.474
rs4934863	10	33583084	C/T	C = 0.190	C = 0.189	0.966	0.992	C
				T = 0.809	T = 0.810
rs4934864	10	33583094	C/T	C = 0.536	C = 0.508	0.426	0.892	C
				T = 0.463	T = 0.491
rs1331326	10	33583896	G/A	G = 0.437	G = 0.465	0.436	1.118	A
				A = 0.562	A = 0.534
rs1331325	10	33584175	A/G	A = 0.261	A = 0.189	0.009	0.660	A
				G = 0.738	G = 0.810
rs4934871	10	33587095	G/A	G = 0.769	G = 0.709	0.039	0.734	G
				A = 0.230	A = 0.290
rs4277057	10	33590696	G/T	G = 0.867	G = 0.860	0.747	0.938	G
				T = 0.132	T = 0.139
rs2776930	10	33591887	C/T	C = 0.210	C = 0.159	0.048	0.708	C
				T = 0.789	T = 0.840
rs1331324	10	33593471	G/C	G = 0.621	G = 0.611	0.764	0.960	G
				C = 0.378	C = 0.388
rs2776932	10	33596412	C/T	C = 0.189	C = 0.227	0.172	1.265	T
				T = 0.810	T = 0.772
rs4934896	10	33597615	A/G	A = 0.860	A = 0.829	0.219	0.790	A
				G = 0.139	G = 0.170
rs2776933	10	33598851	T/C	T =	T = 0.535
				C =	C = 0.465
rs4934901	10	33600052	A/T	A = 0.837	A = 0.804	0.199	0.800	A
				T = 0.162	T = 0.195
rs1015300	10	33601250	G/C	G = 0.948	G = 0.956	0.713	1.200	C
				C = 0.051	C = 0.043
rs2776934	10	33603848	G/C	G = 0.256	G = 0.293	0.222	1.204	C
				C = 0.743	C = 0.706
rs2776935	10	33604304	G/A	G = 0.459	G = 0.379	0.013	0.719	G
				A = 0.540	A = 0.620
rs2776936	10	33604887	C/T	C = 0.293	C = 0.213	0.006	0.654	C
				T = 0.706	T = 0.786
rs2804491	10	33604893	A/C	A = 0.236	A = 0.177	0.035	0.700	A
				C = 0.763	C = 0.822
rs2804492	10	33606052	T/C	T = 0.603	T = 0.627	0.492	1.108	C
				C = 0.396	C = 0.372
rs2804493	10	33609682	A/G	A = 0.234	A = 0.210	0.383	0.868	A
				G = 0.765	G = 0.789
rs2776937	10	33610195	A/G	A = 0.642	A = 0.599	0.269	0.832	A
				G = 0.357	G = 0.400
rs2804494	10	33613422	G/C	G = 0.381	G = 0.311	0.044	0.734	G
				C = 0.618	C = 0.688
rs4934914	10	33614985	G/A	G = 0.920	G = 0.926	0.720	1.098	A
				A = 0.079	A = 0.073
rs2776922	10	33615888	T/C	T = 0.293	T = 0.205	0.003	0.622	T
				C = 0.706	C = 0.794
rs2804495	10	33616506	G/T	G = 0.399	G = 0.323	0.031	0.717	G
				T = 0.600	T = 0.676
rs2804496	10	33617807	T/C	T = 0.364	T = 0.250	˜0.001	0.582	T
				C = 0.635	C = 0.749
rs4934597	10	33618727	T/C	T = 0.224	T = 0.197	0.334	0.849	T
				C = 0.775	C = 0.802
rs2804497	10	33620043	G/T	G = 0.968	G = 0.970	0.891	1.068	T
				T = 0.031	T = 0.029
rs2804498	10	33624713	T/C	T = 0.757	T = 0.770	0.644	1.077	C
				C = 0.242	C = 0.229
rs2026319	10	33625508	G/C	G = 0.901	G = 0.908	0.742	1.083	C
				C = 0.098	C = 0.091
rs1888684	10	33626983	T/C	T = 0.295	T = 0.228	0.051	0.707	T
				C = 0.704	C = 0.771
rs3750733	10	33627257	A/G	A = 0.177	A =
				G = 0.823	G =
rs4934927	10	33632068	G/C	G = 0.896	G = 0.906	0.608	1.127	C
				C = 0.103	C = 0.093
rs2776946	10	33636571	T/C	T = 0.375	T = 0.329	0.190	0.818	T
				C = 0.624	C = 0.670
rs4934599	10	33637968	T/C	T = 0.088	T = 0.074	0.479	0.834	T
				C = 0.911	C = 0.925
rs4934934	10	33638907	A/G	A = 0.917	A = 0.915	0.911	0.973	A
				G = 0.082	G = 0.084
rs2776944	10	33639078	T/G	T = 0.550	T = 0.520	0.448	0.887	T
				G = 0.449	G = 0.479
rs2776943	10	33640220	C/T	C = 0.314	C = 0.259	0.077	0.765	C
				T = 0.685	T = 0.740
rs2804886	10	33640946	G/A	G = 0.870	G = 0.909	0.077	1.495	A
				A = 0.129	A = 0.090
rs2804900	10	33641408	G/A	G = 0.754	G = 0.739	0.644	0.925	G
				A = 0.246	A = 0.261
rs2804902	10	33641439	T/C	T = 0.692	T = 0.680	0.694	0.945	T
				C = 0.307	C = 0.319
rs2768397	10	33642491	G/C	G = 0.904	G = 0.934	0.187	1.515	C
				C = 0.095	C = 0.065
rs2768399	10	33642678	A/G	A = 0.245	A = 0.202	0.172	0.782	A
				G = 0.754	G = 0.797
rs2776941	10	33643953	C/G	C = 0.697	C = 0.731	0.265	1.185	G
				G = 0.302	G = 0.268
rs2804888	10	33645513	G/A	G = 0.053	G = 0.072	0.290	1.392	A
				A = 0.946	A = 0.927
rs2804499	10	33645527	C/G	C = 0.796	C = 0.835	0.184	1.298	G
				G = 0.203	G = 0.164
rs2804889	10	33645870	G/A	G = 0.815	G = 0.859	0.083	1.380	A
				A = 0.184	A = 0.140
rs2804891	10	33646414	G/A	G = 0.303	G = 0.232	0.015	0.696	G
				A = 0.696	A = 0.767
rs2776940	10	33647995	A/T	A = 0.274	A = 0.197	0.009	0.654	A
				T = 0.725	T = 0.802
rs2804897	10	33648548	C/T	C = 0.842	C = 0.900	0.011	1.691	T
				T = 0.157	T = 0.099
rs2804896	10	33649026	T/C	T = 0.540	T = 0.495	0.193	0.835	T
				C = 0.459	C = 0.504
rs2776939	10	33649091	C/T	C = 0.400	C = 0.359	0.214	0.841	C
				T = 0.599	T = 0.640
rs2804894	10	33651097	T/C	T = 0.747	T = 0.797	0.078	1.328	C
				C = 0.252	C = 0.202
rs2804501	10	33652329	A/T	A = 0.381	A = 0.373	0.817	0.969	A
				T = 0.618	T = 0.626
rs2183715	10	33652769	A/C	A = 0.904	A = 0.907	0.884	1.037	C
				C = 0.095	C = 0.092
rs2254822	10	33652838	G/A	G =	G =
				A =	A =
rs2150686	10	33653029	G/A	G = 0.116	G = 0.126	0.632	1.105	A
				A = 0.883	A = 0.873
rs2804893	10	33653545	T/C	T = 0.173	T = 0.132	0.144	0.729	T
				C = 0.827	C = 0.868
rs2804502	10	33653866	T/C	T = 0.765	T = 0.814	0.070	1.347	C
				C = 0.234	C = 0.185
rs2804892	10	33654085	T/C	T = 0.871	T = 0.911	0.063	1.515	C
				C = 0.128	C = 0.088
rs2183714	10	33657076	G/A	G = 0.267	G = 0.185	0.012	0.627	G
				A = 0.732	A = 0.814
rs2804503	10	33658722	C/T	C = 0.416	C = 0.376	0.237	0.845	C
				T = 0.583	T = 0.623
rs1320485	10	33660041	T/C	T = 0.403	T = 0.392	0.745	0.956	T
				C = 0.596	C = 0.607
rs4934603	10	33662649	A/G	A = 0.585	A = 0.642	0.112	1.272	G
				G = 0.414	G = 0.357
rs2804890	10	33662689	C/T	C =	C = 0.559
				T =	T = 0.441
rs1854145	10	33663027	A/G	A = 0.042	A = 0.029	0.485	0.674	A
				G = 0.957	G = 0.970

TABLE 15
Males
								Melanoma
	Chromo-	Chromosome		Male Case	Male Control	M	Odds	Associated
dbSNP rs#	some	Position	Alleles	AF	AF	p-Value	Ratio	Allele
rs6481844	10	33588137	T/C	T = 0.625	T = 0.575	0.134	0.810	T
				C = 0.374	C = 0.424
rs7910405	10	33590041	T/C	T = 0.906	T = 0.872	0.129	0.703	T
				C = 0.093	C = 0.127
rs5784331	10	33590861	—/A	— = 0.386	— = 0.386	0.998	1.000	A
				A = 0.613	A = 0.613
rs6481845	10	33596683	T/C	T = 0.342	T = 0.252	0.004	0.647	T
				C = 0.657	C = 0.747
rs2065364	10	33598008	A/G	A = 0.397	A = 0.338	0.086	0.775	A
				G = 0.602	G = 0.661
rs10643659	10	33599549	—/GTTT	— = 0.185	— = 0.123	0.022	0.617	—
				GTTT = 0.814	GTTT = 0.876
rs7896887	10	33603031	A/G	A = 0.600	A = 0.560	0.256	0.845	A
				G = 0.399	G = 0.439
rs7086456	10	33606418	C/T	C = 0.838	C = 0.866	0.321	1.247	T
				T = 0.161	T = 0.133
rs6481846	10	33606937	G/A	G = 0.810	G = 0.863	0.059	1.474	A
				A = 0.189	A = 0.136
rs7475391	10	33606955	C/T	C = 0.675	C = 0.466	˜0.001	0.419	C
				T = 0.324	T = 0.533
rs7477281	10	33606956	C/T	C = 0.271	C = 0.238	0.300	0.840	C
				T = 0.728	T = 0.761
rs7475393	10	33606959	C/T	C = 0.502	C = 0.463	0.333	0.856	C
				T = 0.497	T = 0.536
rs7475394	10	33606966	C/T	C = 0.757	C = 0.835	0.006	1.630	T
				T = 0.242	T = 0.164
rs7477282	10	33606970	C/T	C =	C =
				T =	T =
rs7475396	10	33606978	C/T	C =	C =
				T =	T =
rs2768420	10	33609638	T/C	T = 0.780	T = 0.782	0.941	1.013	C
				C = 0.219	C = 0.217
rs9418057	10	33612486	C/T	C = 0.870	C = 0.917	0.035	1.654	T
				T = 0.129	T = 0.082
rs7070290	10	33615210	G/A	G = 0.941	G = 0.952	0.557	1.227	A
				A = 0.058	A = 0.047
rs1360457	10	33620935	T/C	T = 0.264	T = 0.204	0.081	0.716	T
				C = 0.735	C = 0.795
rs1411924	10	33623568	G/A	G = 0.134	G = 0.098	0.121	0.701	G
				A = 0.865	A = 0.901
rs5784335	10	33626177	T/—	T = 0.183	T = 0.113	0.024	0.574	T
				— = 0.816	— = 0.886
rs2776925	10	33572278	C/T	C = 0.440	C = 0.459	0.571	1.082	T
				T = 0.559	T = 0.540
rs2776924	10	33572524	G/C	G = 0.751	G = 0.726	0.470	0.881	G
				C = 0.248	C = 0.273
rs1952983	10	33572941	A/C	A = 0.613	A = 0.590	0.511	0.908	A
				C = 0.386	C = 0.409
rs869636	10	33576045	C/T	C = 0.428	C = 0.440	0.720	1.053	T
				T = 0.571	T = 0.559
rs869637	10	33576211	C/T	C = 0.944	C = 0.941	0.908	0.958	C
				T = 0.055	T = 0.058
rs2804470	10	33577636	G/A	G = 0.189	G = 0.167	0.415	0.858	G
				A = 0.810	A = 0.832
rs2776928	10	33578411	T/C	T = 0.918	T = 0.936	0.361	1.295	C
				C = 0.081	C = 0.063
rs999966	10	33578691	C/T	C = 0.822	C = 0.827	0.840	1.039	T
				T = 0.177	T = 0.172
rs2804475	10	33578693	C/G	C = 0.052	C = 0.032	0.435	0.598	C
				G = 0.947	G = 0.967
rs4934858	10	33582294	C/T	C =	C =
				T =	T =
rs4934863	10	33583084	C/T	C = 0.203	C = 0.236	0.294	1.207	T
				T = 0.796	T = 0.763
rs4934864	10	33583094	C/T	C = 0.572	C = 0.520	0.163	0.810	C
				T = 0.427	T = 0.479
rs1331326	10	33583896	G/A	G = 0.441	G = 0.420	0.586	0.916	G
				A = 0.558	A = 0.579
rs1331325	10	33584175	A/G	A = 0.205	A = 0.149	0.037	0.678	A
				G = 0.794	G = 0.850
rs4934871	10	33587095	G/A	G = 0.751	G = 0.754	0.921	1.018	A
				A = 0.248	A = 0.245
rs4277057	10	33590696	G/T	G = 0.843	G = 0.855	0.626	1.105	T
				T = 0.156	T = 0.144
rs2776930	10	33591887	C/T	C = 0.226	C = 0.170	0.056	0.702	C
				T = 0.773	T = 0.829
rs1331324	10	33593471	G/C	G = 0.631	G = 0.572	0.086	0.782	G
				C = 0.368	C = 0.427
rs2776932	10	33596412	C/T	C = 0.206	C = 0.175	0.328	0.816	C
				T = 0.793	T = 0.824
rs4934896	10	33597615	A/G	A = 0.841	A = 0.826	0.582	0.896	A
				G = 0.158	G = 0.173
rs2776933	10	33598851	T/C	T =	T = 0.495
				C =	C = 0.505
rs4934901	10	33600052	A/T	A = 0.812	A = 0.826	0.689	1.104	T
				T = 0.187	T = 0.173
rs1015300	10	33601250	G/C	G = 0.966	G = 0.936	0.124	0.519	G
				C = 0.033	C = 0.063
rs2776934	10	33603848	G/C	G = 0.256	G = 0.219	0.215	0.816	G
				C = 0.743	C = 0.780
rs2776935	10	33604304	G/A	G = 0.482	G = 0.387	0.006	0.680	G
				A = 0.517	A = 0.612
rs2776936	10	33604887	C/T	C =	C =
				T =	T =
rs2804491	10	33604893	A/C	A = 0.225	A = 0.167	0.047	0.694	A
				C = 0.774	C = 0.832
rs2804492	10	33606052	T/C	T = 0.635	T = 0.587	0.186	0.817	T
				C = 0.364	C = 0.412
rs2804493	10	33609682	A/G	A = 0.212	A = 0.210	0.935	0.986	A
				G = 0.787	G = 0.789
rs2776937	10	33610195	A/G	A = 0.621	A = 0.582	0.303	0.849	A
				G = 0.378	G = 0.417
rs2804494	10	33613422	G/C	G = 0.363	G = 0.314	0.138	0.802	G
				C = 0.636	C = 0.685
rs4934914	10	33614985	G/A	G = 0.930	G = 0.949	0.279	1.405	A
				A = 0.069	A = 0.050
rs2776922	10	33615888	T/C	T = 0.265	T = 0.223	0.164	0.796	T
				C = 0.734	C = 0.776
rs2804495	10	33616506	G/T	G = 0.350	G = 0.322	0.392	0.883	G
				T = 0.649	T = 0.677
rs2804496	10	33617807	T/C	T = 0.332	T = 0.212	0.001	0.542	T
				C = 0.667	C = 0.787
rs4934597	10	33618727	T/C	T = 0.192	T = 0.160	0.235	0.801	T
				C = 0.807	C = 0.839
rs2804497	10	33620043	G/T	G = 0.977	G = 0.995	0.108	4.348	T
				T = 0.023	T = 0.005
rs2804498	10	33624713	T/C	T = 0.768	T = 0.777	0.759	1.053	C
				C = 0.231	C = 0.222
rs2026319	10	33625508	G/C	G = 0.919	G = 0.949	0.310	1.636	C
				C = 0.080	C = 0.050
rs1888684	10	33626983	T/C	T = 0.245	T = 0.161	0.038	0.590	T
				C = 0.754	C = 0.838
rs3750733	10	33627257	A/G	A =	A =
				G =	G =
rs4934927	10	33632068	G/C	G = 0.908	G = 0.934	0.193	1.455	C
				C = 0.091	C = 0.065
rs2776946	10	33636571	T/C	T = 0.351	T = 0.315	0.326	0.853	T
				C = 0.648	C = 0.684
rs4934599	10	33637968	T/C	T = 0.084	T = 0.060	0.226	0.707	T
				C = 0.915	C = 0.939
rs4934934	10	33638907	A/G	A = 0.923	A = 0.935	0.552	1.191	G
				G = 0.076	G = 0.064
rs2776944	10	33639078	T/G	T =	T =
				G =	G =
rs2776943	10	33640220	C/T	C = 0.266	C = 0.235	0.307	0.849	C
				T = 0.733	T = 0.764
rs2804886	10	33640946	G/A	G = 0.905	G = 0.934	0.179	1.485	A
				A = 0.094	A = 0.065
rs2804900	10	33641408	G/A	G = 0.746	G = 0.738	0.810	0.957	G
				A = 0.254	A = 0.262
rs2804902	10	33641439	T/C	T = 0.710	T = 0.678	0.327	0.860	T
				C = 0.289	C = 0.321
rs2768397	10	33642491	G/C	G = 0.951	G = 0.945	0.753	0.892	G
				C = 0.048	C = 0.054
rs2768399	10	33642678	A/G	A = 0.200	A = 0.154	0.108	0.727	A
				G = 0.799	G = 0.845
rs2776941	10	33643953	C/G	C = 0.739	C = 0.731	0.836	0.963	C
				G = 0.260	G = 0.268
rs2804888	10	33645513	G/A	G = 0.034	G = 0.074	0.043	2.246	A
				A = 0.965	A = 0.925
rs2804499	10	33645527	C/G	C = 0.855	C = 0.856	0.993	1.002	G
				G = 0.144	G = 0.143
rs2804889	10	33645870	G/A	G = 0.854	G = 0.879	0.323	1.238	A
				A = 0.145	A = 0.120
rs2804891	10	33646414	G/A	G = 0.282	G = 0.240	0.167	0.805	G
				A = 0.717	A = 0.759
rs2776940	10	33647995	A/T	A = 0.235	A = 0.196	0.170	0.793	A
				T = 0.764	T = 0.803
rs2804897	10	33648548	C/T	C = 0.892	C = 0.924	0.170	1.467	T
				T = 0.107	T = 0.075
rs2804896	10	33649026	T/C	T = 0.453	T = 0.525	0.059	1.331	C
				C = 0.546	C = 0.474
rs2776939	10	33649091	C/T	C = 0.370	C = 0.349	0.535	0.913	C
				T = 0.629	T = 0.650
rs2804894	10	33651097	T/C	T = 0.779	T = 0.816	0.206	1.257	C
				C = 0.220	C = 0.183
rs2804501	10	33652329	A/T	A = 0.357	A = 0.374	0.625	1.072	T
				T = 0.642	T = 0.626
rs2183715	10	33652769	A/C	A = 0.921	A = 0.925	0.856	1.051	C
				C = 0.078	C = 0.074
rs2254822	10	33652838	G/A	G = 0.420	G = 0.419	0.979	0.996	G
				A = 0.579	A = 0.580
rs2150686	10	33653029	G/A	G = 0.106	G = 0.112	0.800	1.060	A
				A = 0.893	A = 0.887
rs2804893	10	33653545	T/C	T = 0.145	T = 0.127	0.515	0.857	T
				C = 0.855	C = 0.873
rs2804502	10	33653866	T/C	T = 0.799	T = 0.810	0.689	1.077	C
				C = 0.200	C = 0.189
rs2804892	10	33654085	T/C	T = 0.903	T = 0.932	0.174	1.465	C
				C = 0.096	C = 0.067
rs2183714	10	33657076	G/A	G = 0.219	G = 0.187	0.300	0.825	G
				A = 0.780	A = 0.812
rs2804503	10	33658722	C/T	C = 0.385	C = 0.380	0.871	0.977	C
				T = 0.614	T = 0.619
rs1320485	10	33660041	T/C	T = 0.411	T = 0.352	0.124	0.776	T
				C = 0.588	C = 0.647
rs4934603	10	33662649	A/G	A = 0.591	A = 0.620	0.420	1.131	G
				G = 0.408	G = 0.379
rs2804890	10	33662689	C/T	C = 0.476	C =
				T = 0.524	T =
rs1854145	10	33663027	A/G	A = 0.019	A = 0.067	0.007	3.680	G
				G = 0.981	G = 0.933

Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The assay failed for those SNPs in which the allele frequency is blank. The combined allelotyping p-values for males and females were plotted in FIG. 1A and separately for females and males in FIGS. 1B and 1C, respectively. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele frequency in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIGS. 1A, 1B and 1C can be determined by consulting Table 14 or 15. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.

To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line (or generally top-most curve, e.g., see peak in left-most graph just to the left of position 92150000) provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 1-8 were truncated at that value.

Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is placed at the 3′ end of each gene to show the direction of transcription.

Example 6

ENDO180 Proximal SNPs

It has been discovered that a polymorphic variation in a gene encoding ENDO180 is associated with the occurrence of melanoma.

Forty-eight allelic variants located within or nearby the target gene were identified and subsequently allelotyped in melanoma case and control sample sets as described in Examples 1 and 2. One of the SNPs, designated by SNP_ID “AA” in column 1 of Table 16, is novel and was identified through SNP discovery methods using dye terminator sequencing. Methods of diedeoxynucleotide chain termination chemistry derived sequencing are described by Sanger et al. (Proc. Nat. Acad. Sci. USA 74, 5463-5467, 1997). Briefly, terminators are labeled with fluorescent dyes for automated detection. Fluorescein is measured by an argon ion laser in the sequencing instrument, which transfers light energy to a rhodamine acceptor dye. Each acceptor dye emits light at a characteristic wavelength for detection, identifying the nucleotide that terminated extension of the DNA fragment. Novel SNPs are identified when sequence from multiple samples are compared on one or more strands. The forward and reverse primers used to identify AA are GGCTGACTCAACAGCAGAAG and GGAGGCCTGACAGCAAGG, respectively. All of the polymorphic variants from ENDO180 are set forth in Table 16. The chromosome position provided in column four of Table 16 is based on Genome “Build 34” of NCBI's GenBank and dbSNP 119.

TABLE 16
	relative_position			Snp	Genome	Deduced
SNP Id	in SEQ ID NO: 3	Chrom	ChromPosition	Alleles	Letter	IUPAC
rs2429393	224	17	61200674	A/C	G	K
rs2429392	1,874	17	61202324	A/G	C	Y
rs2465421	2,215	17	61202665	T/C	T	Y
rs2465410	7,585	17	61208035	T/C	G	R
rs2460302	8,025	17	61208475	C/G	G	S
rs2460301	8,687	17	61209137	A/G	T	Y
rs2465459	12,603	17	61213053	C/G	C	S
rs2429391	13,885	17	61214335	C/T	G	R
rs2014055	14,838	17	61215288	C/T	G	R
rs2252814	15,269	17	61215719	C/A	G	K
AA	16,727	17	61217177	G/A	G	R
rs8079582	18,388	17	61218838	C/T	C	Y
rs2429390	18,792	17	61219242	C/T	G	R
rs7209331	19,195	17	61219645	A/G	G	R
rs7405815	19,925	17	61220375	C/T	T	Y
rs4968706	19,949	17	61220399	C/T	T	Y
rs4968613	20,900	17	61221350	C/T	T	Y
rs729647	21,847	17	61222297	G/A	C	Y
rs8072984	22,454	17	61222904	G/A	A	R
rs9896444	24,193	17	61224643	C/T	C	Y
rs4968617	26,825	17	61227275	A/C	A	M
rs7350907	28,667	17	61229117	T/G	T	K
rs2429389	32,261	17	61232711	T/C	A	R
rs2460300	32,268	17	61232718	C/T	A	R
rs2465454	32,873	17	61233323	T/G	A	M
rs2465452	35,165	17	61235615	C/T	G	R
rs7219711	35,449	17	61235899	A/C	C	M
rs2465440	36,833	17	61237283	G/T	G	K
rs2429388	36,952	17	61237402	T/C	A	R
rs3786130	37,964	17	61238414	T/C	T	Y
rs2460289	39,654	17	61240104	G/A	G	R
rs2465428	39,707	17	61240157	C/A	G	K
rs740698	40,072	17	61240522	G/A	C	Y
rs2465425	41,164	17	61241614	T/C	A	R
rs2460290	41,767	17	61242217	T/C	T	Y
rs3826537	42,724	17	61243174	T/C	A	R
rs3169756	43,139	17	61243589	G/T	T	K
rs1558237	47,241	17	61247691	T/C	A	R
rs2429385	49,720	17	61250170	T/C	G	R
rs5821368	50,036	17	61250486	—/T	T	N
rs8072538	50,836	17	61251286	G/A	G	R
rs2251393	51,853	17	61252303	C/T	G	R
rs2251391	51,946	17	61252396	T/C	A	R
rs2068657	57,864	17	61258314	A/G	C	Y
rs8072519	59,414	17	61259864	C/T	C	Y
rs7220505	60,074	17	61260524	C/T	C	Y
rs2460288	65,721	17	61266171	T/C	C	Y
rs4968736	67,995	17	61268445	G/T	T	K

Assay for Verifying and Allelotyping SNPs

The methods used to verify and allelotype the seventy-six proximal SNPs of Table 16 are the same methods described in Examples 1 and 2 herein. The primers used in these assays are provided in Table 17 and Table 18, respectively.

	TABLE 17
	dbSNP rs #	Forward PCR Primer	Reverse PCR Primer
	rs2429393	GCCTTCTTGTCATTCTTTTT	AGCCGAGATAGTGCCACTC
	rs2429392	CTGGGGGACAGAGTGAAACT	CAAGTGTTACTTGAAAGACC
	rs2465421	AACAACTTAGATACCCCCCC	CTCAGGAACTAATCATTCTGG
	rs2465410	GACCATATGGTGATAAGGGC	GAGAATTTCATAGATGCCAGC
	rs2460302	AAGAGAAAAGGCGTCCTGAG	CTCTGCCCGCTTTGTATGTG
	rs2460301	TCCTTTGTCACATGAGGCAC	AAAGTTGGGTGGATTTGAAC
	rs2465459	TCCTGGGTCCAAATCTCAAG	TGACTGTCTTTGGAGAATGG
	rs2429391	TCTTTCCACCTATCTCCTCG	TCTGTAAAGTGGGTGTGCTG
	rs2014055	TGCAGTCCATGGCTGAAGAT	TGTGATGCCTTCGTGTCTTG
	rs2252814	AATCTGTCCCTCATGGCTCC	ACCTATGTGCTCTGCCCTAC
	AA	AGAAGGTCTCGCAGTCGTTA	TAGTGTAGCCTTTTGGTGGG
	rs8079582	TTAAGGGGTGGTGAGTGATG	CTACTGAGCTCAAGCAATCC
	rs2429390	GATTCAATTACTCTGGGGCG	AGTATGGTCATCCAACCAGC
	rs7209331	TGGGCAAGCAGCTTAGTCTC	TCACAACAACCTTGCAAGGG
	rs7405815	AGTGCAGTGGCACAATCTCC	GAGGCTGGAGCATGAGAATC
	rs4968706	TCTCATCTCCAGGTTCAAGC	GTGGCACACTCATGCCTATAA
	rs4968613	TTGCCAAGACCAAGTAAGGG	TTCAGGTTCACCTTCTAGGG
	rs729647	TCTGGGAGAGTTTGGAGAGG	AACCAACCCACTGGGTTGAC
	rs8072984	TAACTAGGATGTCCTTCAGC	ATCTGGGGCCCGGTGAGAT
	rs9896444	AACTGCTTGTGCTCTCATCC	TTCTGACATGTCTGTGTCCC
	rs4968617	TCCTCGCTTCACCAAGGCAA	GGATGAAGTCATGTACACCC
	rs7350907	TGAACAGGATTGTCCTTAGC	CTACTGCCTTTCCCACCATG
	rs2429389	TGTACATGACAGCCAGCCGA	ATGACTTCTGCCCAGGCTCG
	rs2460300	ACAGACTGATGACTTCTGCC	CAGAGTGCGCAGTCAGCTGT
	rs2465454	CACTGATCTAGAACACTCAC	TCACTGTAGTAGCACCTTCC
	rs2465452	TGATCTCAGGTGATCCACCC	TTCAAAAGAACATTACACGG
	rs7219711	TTTTTAAGGTAGAAGAGGTG	CAGCCTGGGCGAGAGATTGA
	rs2465440	AAGAGGCTGTCCCACAAACC	CTCAGGCTGTAATGCCCCTT
	rs2429388	CCTGCCATACCCCTTAATAC	TATTCAGCTCAGTCCAGCCG
	rs3786130	TAGTAGAGACGGGGTTTCAC	GAAGCTGCTGCTAATAGATC
	rs2460289	CCCAGACCAAGGCTTGGTAG	CTCCCTGTCCATTTGTTAGC
	rs2465428	AGGCACAAGGCCAGGAGAAG	ACACCTACCAAGCCTTGGTC
	rs740698	GTGGGCTCCCGACACTTTTG	AATAGTCAGGATAGGGTGCG
	rs2465425	GGGACAGGGAGTCGGTTCTA	AGGAAAGAAGGCACTGAGGG
	rs2460290	AGGCATGAGCCACCACATCA	GCCTCAGTTTCCTCGTATGT
	rs3826537	CATCCTGGTGTCAGACATGG	AACTGGACAGGCAGCTGGTG
	rs3169756	ACAGAGCTGAGGCTGCCAG	CTTCTTTGCAGAGCCCGAGG
	rs1558237	ACCACATGGCTCTCCTGGAA	TTTGCCTTGTGCCTGCAATG
	rs2429385	CCTGGTTGAAACTACTACTG	CGAGATTGCGCCATCGCACT
	rs5821368	CCTACTGGTTGGTTTTCAAG	TCACCTTAAAATCTGGTCCC
	rs8072538	TGGCTCATGCCTATAAGCTC	CTATGGCCCAGGCTGATTTC
	rs2251393	ACCAAAGCGTTCACAGTTAG	ATAGATGCTCAAGCCAGACC
	rs2251391	CTTGGGGACGTAGAAAGAAG	CATTTCTCAAAGCCAGGTCG
	rs2068657	ACCTTCAGCTAGGCTCTTCG	GATTGGATGAAAAGCGAGGC
	rs8072519	GTCTAGCGTCTAGTAGCTTC	ATTCATGCACTGCCCTGTAC
	rs7220505	CCTACTTTCATTTGGGTGCC	TGAGCCATGATTGGTGCCAC
	rs2460288	ATGCGGCGAGCCAAATAACA	GTGTAACCTGTGACCTAAGC
	rs4968736	AGAAAGCAGCAAGGAACGAG	TGCTGGTGGCTGATCCTTAG

	TABLE 18!Term? ? !dbSNP rs #? Extend Primer? Mix
	rs2429393	AGTGTCGCTCTATTGCT	ACT
	rs2429392	GAGTGAAACTCGTCTCC	ACT
	rs2465421	CAAACAAAAGAAATGTGTAGC	ACT
	rs2465410	CAATACCCTCAGTGCCT	ACT
	rs2460302	GCTCTGTGTTCTTTGTAC	ACT
	rs2460301	ACATGAGGCACAGCTTC	ACT
	rs2465459	AGTTCTCTCTCTTCCCC	ACT
	rs2429391	ACCCTCTGTAGAAGTCA	ACG
	rs2014055	GCTGAAGATGAGGAAGA	ACG
	rs2252814	TCCAGTCCCCTGGACAT	CGT
	AA	CAGTCGTTACCTGCCACCA	ACG
	rs8079582	GGCTCACACCTATAATCC	ACG
	rs2429390	CATTTCTAACAAGCCCTC	ACG
	rs7209331	CTCATTGCAAATGGAGAAT	ACT
	rs7405815	GTTCAAGCGATTCTCATC	ACG
	rs4968706	TCAAGCGATTCTCATGC	ACG
	rs4968613	CCTCAGCTGCCCTCGGA	ACG
	rs729647	GAGGTGACTGGGAGGCCT	ACG
	rs8072984	ATTTTGTGGCCCTGTGA	ACG
	rs9896444	TGAGGCTTATGGGTTCATCC	ACG
	rs4968617	CACCAAGGCAAGTCAAA	ACT
	rs7350907	TTGTCCTTAGCTAGCCT	ACT
	rs2429389	GCGCAGTCAGCTGTGCA	ACT
	rs2460300	CCAGGCTCGCCCAGCAT	ACG
	rs2465454	CCAAATTATTTGGACAACC	ACT
	rs2465452	CCAAAGTGCTGGGATTA	ACG
	rs7219711	GAAGAGGTGTAATTTTTTTTTT	ACT
	rs2465440	TCTTAGGAGGTGAGCAG	CGT
	rs2429388	CCCTTAATACACTTGCAC	ACT
	rs3786130	GCGCCCAGCCCTAGGAC	ACT
	rs2460289	GGCTTGGTAGGTGTCAG	ACG
	rs2465428	CACACCAGGCAAAGACC	CGT
	rs740698	CACTTTTGCCCTGGGCC	ACG
	rs2465425	AGTCGGTTCTAGAACAC	ACT
	rs2460290	CCACCACATCAGTCTGG	ACT
	rs3826537	CATGGAAATGAATGAGCA	ACT
	rs3169756	CAGGTGGGAAGAGAGACAC	CGT
	rs1558237	TCTCCTGGAACGGAGCC	ACT
	rs2429385	TTTTTTTGAGATGGAGTTTC	ACT
	rs5821368	CATCACTTTAACTGGAACATA	ACG
	rs8072538	GGCCAAGGCAGGTAGAC	ACG
	rs2251393	CACAGTTAGATTTTCACCT	ACG
	rs2251391	TAGAAAGAAGGGCTGGC	ACT
	rs2068657	AGGCTCTTCGCGGACAC	ACT
	rs8072519	TCCCTGATCCTCATCTC	ACG
	rs7220505	GGTCTCACTCTGTCACA	ACG
	rs2460288	GGATGAGGTGAAAACAG	ACT
	rs4968736	GCAGTGTGGCCAGGGTC	CGT

Genetic Analysis

Allelotyping results are shown for female (F) and male (M) cases and controls in Table 19 and Table 20, respectively. Allele frequency is noted in the fourth and fifth columns for melanoma pools and control pools, respectively.

TABLE 19
Females
								Melanoma
	Chromo-	Chromosome		Female Case	Female Control	F	Odds	Associated
dbSNP rs#	some	Position	Alleles	AF	AF	p-Value	Ratio	Allele
rs2429393	17	61200674	A/C	A = 0.754	A = 0.729	0.416	0.879	A
				C = 0.245	C = 0.270
rs2429392	17	61202324	A/G	A = 0.753	A = 0.703	0.089	0.775	A
				G = 0.246	G = 0.296
rs2465421	17	61202665	T/C	T = 0.456	T = 0.477	0.535	1.089	C
				C = 0.543	C = 0.522
rs2465410	17	61208035	T/C	T = 0.873	T = 0.862	0.619	0.905	T
				C = 0.126	C = 0.137
rs2460302	17	61208475	C/G	C = 0.500	C = 0.515	0.681	1.059	G
				G = 0.499	G = 0.484
rs2460301	17	61209137	A/G	A = 0.482	A = 0.508	0.456	1.106	G
				G = 0.517	G = 0.491
rs2465459	17	61213053	C/G	C = 0.688	C = 0.673	0.644	0.934	C
				G = 0.311	G = 0.326
rs2429391	17	61214335	C/T	C = 0.473	C = 0.437	0.304	0.867	C
				T = 0.526	T = 0.562
rs2014055	17	61215288	C/T	C = 0.807	C = 0.785	0.416	0.874	C
				T = 0.192	T = 0.214
rs2252814	17	61215719	C/A	C = 0.562	C = 0.541	0.562	0.917	C
				A = 0.437	A = 0.458
AA	17	61217177	G/A	G = 0.893	G = 0.922	0.247	1.416	A
				A = 0.106	A = 0.077
rs8079582	17	61218838	C/T	C = 0.902	C = 0.906	0.856	1.044	T
				T = 0.097	T = 0.093
rs2429390	17	61219242	CAT	C = 0.452	C = 0.415	0.272	0.859	C
				T = 0.547	T = 0.584
rs7209331	17	61219645	A/G	A = 0.226	A = 0.154	0.011	0.626	A
				G = 0.773	G = 0.845
rs7405815	17	61220375	C/T	C = 0.078	C = 0.054	0.214	0.676	C
				T = 0.921	T = 0.945
rs4968706	17	61220399	C/T	C = 0.165	C = 0.063	˜0.001	0.340	C
				T = 0.834	T = 0.936
rs4968613	17	61221350	C/T	C = 0.132	C = 0.100	0.157	0.731	C
				T = 0.867	T = 0.899
rs729647	17	61222297	A/G	A = 0.700	A = 0.711	0.035	1.053	G
				G = 0.299	G = 0.288
rs8072984	17	61222904	G/A	G = 0.216	G = 0.137	0.003	0.580	G
				A = 0.783	A = 0.862
rs9896444	17	61224643	C/T	C = 0.893	C = 0.932	0.059	1.649	T
				T = 0.106	T = 0.067
rs4968617	17	61227275	A/C	A = 0.695	A = 0.732	0.230	1.201	C
				C = 0.304	C = 0.267
rs7350907	17	61229117	T/G	T = 0.774	T = 0.845	0.014	1.586	G
				G = 0.225	G = 0.154
rs2429389	17	61232711	T/C	T = 0.011	T = 0.026	0.227	2.403	C
				C = 0.989	C = 0.974
rs2460300	17	61232718	C/T	C = 0.983	C = 0.973	0.385	0.609	T
				T = 0.167	T = 0.027
rs2465454	17	61233323	T/G	T = 0.186	T = 0.028	0.471	1.533	T
				G = 0.981	G = 0.972
rs2465452	17	61235615	C/T	C = 0.047	C = 0.039	0.671	0.826	C
				T = 0.952	T = 0.960
rs7219711	17	61235899	A/C	A = 0.809	A = 0.790	0.512	0.891	A
				C = 0.190	C = 0.209
rs2465440	17	61237283	G/T	G = 0.672	G = 0.653	0.568	0.918	G
				T = 0.327	T = 0.346
rs2429388	17	61237402	T/C	T = 0.030	T = 0.037	0.660	1.227	C
				C = 0.969	C = 0.962
rs3786130	17	61238414	T/C	T = 0.733	T = 0.749	0.660	1.090	C
				C = 0.266	C = 0.250
rs2460289	17	61240104	G/A	G = 0.045	G = 0.030	0.368	0.655	G
				A = 0.954	A = 0.969
rs2465428	17	61240157	C/A	C = 0.016	C = 0.021	0.685	1.353	A
				A = 0.984	A = 0.978
rs740698	17	61240522	G/A	G = 0.142	G = 0.113	0.291	0.766	G
				A = 0.857	A = 0.886
rs2465425	17	61241614	T/C	T = 0.027	T = 0.032	0.725	1.210	C
				C = 0.972	C = 0.967
rs2460290	17	61242217	T/C	T = 0.039	T = 0.028	0.553	0.716	T
				C = 0.960	C = 0.971
rs3826537	17	61243174	T/C	T = 0.644	T = 0.676	0.379	1.154	C
				C = 0.355	C = 0.323
rs3169756	17	61243589	G/T	G = 0.067	G = 0.042	0.125	0.609	G
				T = 0.932	T = 0.957
rs1558237	17	61247691	T/C	T = 0.070	T = 0.063	0.726	0.892	T
				C = 0.929	C = 0.936
rs2429385	17	61250170	T/C	T = 0.956	T = 0.952	0.811	0.913	T
				C = 0.043	C = 0.047
rs5821368	17	61250486	—/T	— = 0.375	— = 0.396	0.524	1.091	T
				T = 0.624	T = 0.603
rs8072538	17	61251286	G/A	G = 0.016	G = 0.022	0.619	1.379	A
				A = 0.984	A = 0.978
rs2251393	17	61252303	C/T	C = 0.222	C = 0.203	0.532	0.896	C
				T = 0.777	T = 0.796
rs2251391	17	61252396	T/C	T = 0.146	T = 0.099	0.078	0.648	T
				C = 0.853	C = 0.900
rs2068657	17	61258314	A/G	A = 0.061	A = 0.062	0.960	1.016	G
				G = 0.938	G = 0.937
rs8072519	17	61259864	C/T	C = 0.763	C = 0.828	0.032	1.496	T
				T = 0.236	T = 0.171
rs7220505	17	61260524	C/T	C = 0.714	C = 0.701	0.704	0.942	C
				T = 0.285	T = 0.298
rs2460288	17	61266171	T/C	T = 0.168	T = 0.198	0.250	1.221	C
				C = 0.831	C = 0.801
rs4968736	17	61268445	G/T	G = 0.302	G = 0.306	0.884	1.021	T
				T = 0.697	T = 0.693

TABLE 20
Males
								Melanoma
	Chromo-	Chromosome		Male Case	Male Control	M	Odds	Associated
dbSNP rs#	some	Position	Alleles	AF	AF	p-Value	Ratio	Allele
rs2429393	17	61200674	A/C	A = 0.705	A = 0.726	0.524	1.108	C
				C = 0.294	C = 0.273
rs2429392	17	61202324	A/G	A = 0.692	A = 0.720	0.412	1.142	G
				G = 0.307	G = 0.279
rs2465421	17	61202665	T/C	T = 0.490	T = 0.466	0.496	0.907	T
				C = 0.509	C = 0.533
rs2465410	17	61208035	T/C	T = 0.848	T = 0.875	0.263	1.259	C
				C = 0.151	C = 0.124
rs2460302	17	61208475	C/G	C = 0.545	C = 0.527	0.618	0.933	C
				G = 0.454	G = 0.472
rs2460301	17	61209137	A/G	A = 0.536	A = 0.489	0.178	0.830	A
				G = 0.463	G = 0.510
rs2465459	17	61213053	C/G	C = 0.659	C = 0.655	0.905	0.982	C
				G = 0.340	G = 0.344
rs2429391	17	61214335	C/T	C = 0.503	C = 0.437	0.063	0.768	C
				T = 0.496	T = 0.562
rs2014055	17	61215288	C/T	C = 0.812	C = 0.812	0.994	0.999	C
				T = 0.187	T = 0.187
rs2252814	17	61215719	C/A	C = 0.605	C = 0.539	0.064	0.762	C
				A = 0.394	A = 0.460
AA	17	61217177	G/A	G = 0.908	G = 0.943	0.067	1.685	A
				A = 0.091	A = 0.056
rs8079582	17	61218838	C/T	C = 0.908	C = 0.940	0.095	1.594	T
				T = 0.091	T = 0.059
rs2429390	17	61219242	C/T	C = 0.477	C = 0.390	0.011	0.701	C
				T = 0.522	T = 0.609
rs7209331	17	61219645	A/G	A = 0.167	A = 0.100	0.009	0.558	A
				G = 0.832	G = 0.899
rs7405815	17	61220375	C/T	C = 0.067	C = 0.045	0.212	0.658	C
				T = 0.932	T = 0.954
rs4968706	17	61220399	C/T	C = 0.096	C = 0.071	0.293	0.725	C
				T = 0.903	T = 0.928
rs4968613	17	61221350	C/T	C = 0.111	C = 0.081	0.155	0.706	C
				T = 0.888	T = 0.918
rs729647	17	61222297	A/G	A = 0.660	A = 0.740	0.033	1.472	G
				G = 0.339	G = 0.259
rs8072984	17	61222904	G/A	G = 0.161	G = 0.098	0.013	0.567	G
				A = 0.838	A = 0.901
rs9896444	17	61224643	C/T	C = 0.917	C = 0.965	0.024	2.511	T
				T = 0.082	T = 0.034
rs4968617	17	61227275	A/C	A = 0.681	A = 0.757	0.018	1.463	C
				C = 0.318	C = 0.242
rs7350907	17	61229117	T/G	T = 0.804	T = 0.845	0.165	1.326	G
				G = 0.195	G = 0.154
rs2429389	17	61232711	T/C	T = 0.055	T = 0.031	0.142	0.548	T
				C = 0.944	C = 0.968
rs2460300	17	61232718	CAT	C = 0.961	C = 0.974	0.339	1.571	T
				T = 0.038	T = 0.025
rs2465454	17	61233323	T/G	T = 0.056	T = 0.027	0.088	0.479	T
				G = 0.943	G = 0.972
rs2465452	17	61235615	C/T	C = 0.057	C = 0.032	0.117	0.545	C
				T = 0.942	T = 0.967
rs7219711	17	61235899	A/C	A = 0.789	A = 0.793	0.903	1.023	C
				C = 0.210	C = 0.206
rs2465440	17	61237283	G/T	G = 0.672	G = 0.625	0.173	0.813	G
				T = 0.327	T = 0.374
rs2429388	17	61237402	T/C	T = 0.053	T = 0.026	0.096	0.492	T
				C = 0.946	C = 0.973
rs3786130	17	61238414	T/C	T = 0.754	T = 0.796	0.272	1.270	C
				C = 0.245	C = 0.203
rs2460289	17	61240104	G/A	G = 0.039	G = 0.044	0.806	1.123	A
				A = 0.960	A = 0.955
rs2465428	17	61240157	C/A	C = 0.047	C = 0.028	0.236	0.590	C
				A = 0.952	A = 0.971
rs740698	17	61240522	G/A	G = 0.130	G = 0.083	0.081	0.602	G
				A = 0.869	A = 0.916
rs2465425	17	61241614	T/C	T = 0.040	T = 0.019	0.237	0.470	T
				C = 0.960	C = 0.981
rs2460290	17	61242217	T/C	T = 0.084	T = 0.048	0.105	0.551	T
				C = 0.915	C = 0.951
rs3826537	17	61243174	T/C	T =	T =
				C =	C =
rs3169756	17	61243589	G/T	G = 0.050	G = 0.031	0.250	0.619	G
				T = 0.949	T = 0.968
rs1558237	17	61247691	T/C	T = 0.071	T = 0.068	0.891	0.960	T
				C = 0.928	C = 0.931
rs2429385	17	61250170	T/C	T = 0.934	T = 0.950	0.366	1.342	C
				C = 0.065	C = 0.049
rs5821368	17	61250486	—/T	— = 0.399	— = 0.407	0.808	1.034	T
				T = 0.600	T = 0.592
rs8072538	17	61251286	G/A	G = 0.029	G = 0.023	0.646	0.786	G
				A = 0.970	A = 0.976
rs2251393	17	61252303	C/T	C = 0.215	C = 0.178	0.187	0.793	C
				T = 0.784	T = 0.821
rs2251391	17	61252396	T/C	T =	T =
				C =	C =
rs2068657	17	61258314	A/G	A = 0.072	A = 0.060	0.557	0.832	A
				G = 0.927	G = 0.939
rs8072519	17	61259864	C/T	C = 0.793	C = 0.848	0.042	1.457	T
				T = 0.206	T = 0.151
rs7220505	17	61260524	C/T	C = 0.710	C = 0.707	0.944	0.989	C
				T = 0.289	T = 0.292
rs2460288	17	61266171	T/C	T = 0.169	T = 0.187	0.505	1.131	C
				C = 0.830	C = 0.812
rs4968736	17	61268445	G/T	G = 0.277	G = 0.283	0.850	1.029	T
				T = 0.722	T = 0.716

Allelotyping results were considered particularly significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The assay failed for those SNPs in which the allele frequency is blank. The combined allelotyping p-values for males and females were plotted in FIG. 2A and separately for females and males in FIGS. 2B and 2C, respectively. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele frequency in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIGS. 2A, 2B and 2C can be determined by consulting Table 19 or 20. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.

To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line (or generally top-most curve, e.g., see peak in left-most graph just to the left of position 92150000) provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10⁻⁸ were truncated at that value.

Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is placed at the 3′ end of each gene to show the direction of transcription.

Example 7

CDK10 Proximal SNPs

It has been discovered that a polymorphic variation (rs8404) in the untranslated region of a gene encoding cyclin-dependent kinase 10 (CDK10) is associated with the occurrence of melanoma. See Table 3. Subsequently, one-hundred-three allelic variants located within or nearby the target gene were identified and subsequently allelotyped in melanoma case and control sample sets as described in Examples 1 and 2. Several SNPs, designated by SNP_ID “AA”, “AB”, and “AC” in column 1 of Table 10, are novel and were identified through SNP discovery methods using dye terminator sequencing. Methods of diedeoxynucleotide chain termination chemistry derived sequencing are described by Sanger et al. (Proc. Nat. Acad. Sci. USA 74, 5463-5467, 1997). Briefly, terminators are labeled with fluorescent dyes for automated detection. Fluorescein is measured by an argon ion laser in the sequencing instrument, which transfers light energy to a rhodamine acceptor dye. Each acceptor dye emits light at a characteristic wavelength for detection, identifying the nucleotide that terminated extension of the DNA fragment. Novel SNPs are identified when sequence from multiple samples are compared on one or more strands. The forward and reverse primers used to identify AA are TTCTTCTTGCCCAGATGGAG and GGCTAGCTTTGGGAGATGTTT, respectively. The forward and reverse primers used to identify AB are CACAGAACTGAGTGGCTGGA and AGAGCTGAGCCTGCAGTGA, respectively. The forward and reverse primers used to identify AC are GGAGGCTGTGTCCTGTGGAG and CTATGGGAGGCAGGAGCTGA, respectively. The polymorphic variants are set forth in Table 21. The chromosome position provided in column four of Table 21 is based on Genome “Build 34” of NCBI's GenBank and dbSNP build “119”.

TABLE 21
		Position			Allele
dbSNP	Chromo-	in SEQ	Chromosome	Allele	Present in	IUPAC
rs#	some	ID NO.: 4	Position	Variants	SEQ ID NO: 4	Code
rs460879	16	234	89456684	T/C	C	Y
rs460984	16	519	89456969	T/C	C	Y
rs2437957	16	2,993	89459443	C/T	G	R
rs3815949	16	3,261	89459711	C/G	C	S
rs2437956	16	3,596	89460046	G/A	T	Y
rs2437955	16	3,620	89460070	G/T	C	M
rs2434872	16	4,260	89460710	C/G	C	S
rs467357	16	4,742	89461192	G/A	A	R
rs258337	16	8,055	89464505	A/T	T	W
rs258336	16	8,176	89464626	T/G	T	K
rs258335	16	8,289	89464739	A/G	G	R
rs164752	16	9,735	89466185	G/A	G	R
rs154663	16	13,380	89469830	T/C	T	Y
rs164753	16	14,940	89471390	T/C	C	Y
rs258332	16	15,028	89471478	G/A	G	R
rs2010623	16	16,370	89472820	C/T	A	R
rs187283	16	16,681	89473131	G/A	A	R
rs258330	16	16,919	89473369	T/G	T	K
rs258328	16	17,659	89474109	C/T	C	Y
rs459920	16	18,172	89474622	T/C	T	Y
rs166297	16	18,530	89474980	G/A	A	R
rs258318	16	19,395	89475845	T/C	T	Y
rs258317	16	19,583	89476033	C/T	C	Y
rs171805	16	20,959	89477409	G/A	A	R
rs2081984	16	21,271	89477721	C/T	C	Y
rs464586	16	21,433	89477883	C/T	A	R
rs460319	16	21,438	89477888	G/T	G	K
rs447735	16	21,694	89478144	A/G	T	Y
rs2377058	16	22,176	89478626	T/C	A	R
rs604868	16	23,522	89479972	G/A	T	Y
rs2118193	16	27,248	89483698	C/T	G	R
rs467035	16	27,630	89484080	C/G	C	S
rs2115401	16	27,954	89484404	C/T	T	Y
rs417323	16	33,622	89490072	T/G	T	K
rs2377233	16	34,247	89490697	C/G	G	S
AA	16	36,589	89493039	G/C	C	S
rs9746114	16	38,672	89495122	C/G	G	S
rs3751700	16	39,539	89495989	G/A	G	R
rs2277905	16	39,846	89496296	A/G	A	R
rs397891	16	40,376	89496826	C/G	G	S
rs3794638	16	40,781	89497231	G/T	C	M
rs3794637	16	40,915	89497365	G/A	C	Y
rs258324	16	41,600	89498050	C/A	T	K
rs258323	16	42,039	89498489	C/G	G	S
rs2075880	16	42,561	89499011	A/G	A	R
rs258322	16	43,248	89499698	C/T	A	R
rs258321	16	43,818	89500268	C/T	A	R
rs164744	16	44,113	89500563	A/C	T	K
rs3833829	16	44,126	89500576	A/—	C	N
AB	16	44,544	89500994	T/C	C	Y
rs164743	16	44,776	89501226	A/G	T	Y
rs164742	16	45,070	89501520	C/T	A	R
rs187282	16	46,318	89502768	T/C	A	R
rs465507	16	47,837	89504287	C/G	C	S
rs2162943	16	47,997	89504447	G/A	C	Y
AC	16	48,304	89504754	G/C	C	S
rs1946482	16	49,755	89506205	T/C	T	Y
rs8404	16	49,992	89506442	C/T	T	Y
rs1045814	16	50,260	89506710	G/A	C	Y
rs4247353	16	50,559	89507009	T/C	T	Y
rs462769	16	50,608	89507058	A/G	T	Y
rs3803690	16	50,704	89507154	C/G	G	S
rs3751696	16	50,964	89507414	A/T	A	W
rs9972864	16	52,542	89508992	A/G	G	R
rs10567226	16	53,307	89509757	TTT/—	T	N
rs417414	16	53,493	89509943	A/G	C	Y
rs154661	16	53,916	89510366	G/C	G	S
rs4785704	16	59,715	89516165	G/A	A	R
rs4785584	16	59,729	89516179	C/T	T	Y
rs4785585	16	59,750	89516200	C/T	C	Y
rs4785705	16	59,759	89516209	T/C	C	Y
rs4785586	16	59,761	89516211	G/A	G	R
rs4785587	16	59,964	89516414	A/G	G	R
rs2016968	16	60,251	89516701	C/G	C	S
rs3751693	16	61,741	89518191	C/T	G	R
rs3809646	16	74,200	89530650	A/G	C	Y
rs4785590	16	77,512	89533962	G/C	G	S
rs2099105	16	80,900	89537350	A/G	T	Y
rs4785708	16	83,914	89540364	C/T	C	Y
rs4785710	16	84,101	89540551	T/C	C	Y
rs4785591	16	84,858	89541308	C/T	C	Y
rs4785592	16	84,860	89541310	C/G	G	S
rs4785593	16	84,972	89541422	C/T	C	Y
rs4785711	16	85,291	89541741	C/G	C	S
rs4785712	16	85,299	89541749	G/C	C	S
rs4785713	16	85,443	89541893	G/C	C	S
rs4785714	16	85,749	89542199	C/A	C	M
rs4785594	16	85,861	89542311	C/G	G	S
rs3803689	16	87,403	89543853	A/G	C	Y
rs4785715	16	87,480	89543930	G/A	A	R
rs3764258	16	88,359	89544809	C/G	C	S
rs4785716	16	88,472	89544922	T/C	T	Y
rs4785717	16	88,478	89544928	G/A	A	R
rs2077001	16	89,435	89545885	C/T	G	R
rs2377049	16	90,313	89546763	A/C	T	K
rs2003522	16	90,631	89547081	C/G	C	S
rs1230	16	92,200	89548650	C/T	C	Y
rs1800359	16	92,606	89549056	A/G	A	R
rs1061646	16	93,322	89549772	T/C	G	R
rs1800358	16	96,664	89553114	C/T	T	Y
rs2286392	16	96,894	89553344	C/T	A	R
rs2074904	16	98,891	89555341	T/C	A	R
rs2074903	16	99,008	89555458	A/G	T	Y

Assay for Verifying and Allelotyping SNPs

The methods used to verify and allelotype the one-hundred-three proximal SNPs of Table 21 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 22 and Table 23, respectively.

TABLE 22
dbSNP rs #	Forward PCR primer	Reverse PCR primer
rs460879	TCCAGCCTCTAACCCACAAC	CGAAACGCTGTGTCACCAAC
rs460984	ATGCTCTGGACAACAGGTGG	TGAGGGAACGAAAAGTGCAG
rs2437957	ATCCAGCTTCCCTCAACCTC	CAGCTCAGAGTTGACGGAAG
rs3815949	TTTTTCTGCAGAAGGGCCTG	CACACACCACCAAGCTCTTC
rs2437956	TCAACACTGGGCTCCTAGGG	TCTCCTGACCTCGTGATCTG
rs2437955	TCAACACTGGGCTCCTAGGG	TCTCCTGACCTCGTGATCTG
rs2434872	TAGACACCAGCTCTGTAGGG	ATTACAGGCATGAGCCACTG
rs467357	TCATCTCTGTGCTCTGGACG	TGTGTGGTGCAGCCCAGAAT
rs258337	TAGAATCCAAAAGATGGTGG	TGCTGGGATTACAGGTGAAC
rs258336	CTTTGAGGAGAAAGAGTCTG	TTAAAGCCAGGGTTTGAGGC
rs258335	TCCTGACCTCAAGTGATCTG	AAAGAGCTGATTTCCAGCGG
rs164752	AAGTGCTGGAATTACAGCCG	AAAATATGCTGGCCAGGCCG
rs154663	ATTGCTCGAACCTTGAACCG	GACAGAGTCTCACTCTGTAG
rs164753	AGTGAGAAGAACAGAAGGGC	GCCAAGCCACATCAATATCC
rs258332	TGTGTCCTCACCCAAATCTC	CCTGCCCCCATAATTCAATC
rs2010623	CCATGACGCCCAGCTAATTT	AACCAGGAGTTTGAGGCCAG
rs187283	CCGGGTTCAAGCAATTCTTC	AATTACCCAGGCATGGTGGC
rs258330	GCTTTTTTCACTCAGCATGG	GGTAGAGTATACTTAATTGC
rs258328	TCAGGTTTCACCATGTTGCC	CAGAACTTTGGGAAGCCTAG
rs459920	AACAGCCATGTGTAACCCTC	TAATCGCAGGAGAGACACAC
rs166297	ACTTCATTCCTTGAACCGGG	ACTGCATTCTCATGAGGAGC
rs258318	TGCGTCTGGCCTAATATTTC	CACTATTGAAATTTTCTAGTC
rs258317	TGAACTCCTGACCTCAAGTG	GCCAAGTGTAGTGATTCACG
rs171805	ACCATGGTCTGCTTGGCAAC	GCCTTTTGTTATGCCCAGAC
rs2081984	TTCCAAGTAGCTGGGACCAC	TATTACACTGGAACAGCTCG
rs464586	GACCTTCAAGATCCTGTCTC	ATAGCCTCATCTGTGTCAGC
rs460319	GACCTTCAAGATCCTGTCTC	ATAGCCTCATCTGTGTCAGC
rs447735	ATGGCTTGGCTTGTCTGTAC	CACAGCAGCTTCTGCTATAG
rs2377058	GGGTTAGAAGACTCAGTCAC	TACCAAGTGTCCCACAAAGC
rs604868	CAACCCTGGTGTACCCTCC	CTGCCCCCGCCGTGAGAAA
rs2118193	TTTTTGAGACGGAGTCTCGC	AGGAGAATGGCTGAACCTGG
rs467035	CGTGTCTGTTTCCACTCTTG	CCCTGTGTAGAAAAGAAGGC
rs211540	TTGGCATCTTTGGGCGTTTTG	CAACCCGCTTCAGCCTTGAG
rs417323	GAGGACTGAAGAAAGAATTTG	GCGAGACTCTGTCTCAAATA
rs2377233	TCTCTTTTTGGACTTCAGGG	TCCCACAGTGCTAGGATTAC
AA	GGTCCTGCAGATAACAATGC	AGCCGTAGGTATCAGACATG
rs9746114	TGAATGGAGTCTAGGTCTGG	TGTTTATGGCCAGTTTTGCG
rs3751700	TCAGGTCTTCCATGAGTGAG	TTCAAGCTTAGCTTCTGGGC
rs2277905	TCCTCCAGTTGGGAGTCCTT	CACCTGGAAGACTCTCTCAC
rs397891	CGGGAGCGTCTCTTGGTAAC	CAGGCGCGAAAGCTCCTTC
rs3794638	AGCCTGCTCTTCCCAAGTCC	CGGTCCCTGGAGATCTGAG
rs3794637	GAGCCTTCAAGCTCGAACTC	AGCCGCGAGCCACTTGTTTG
rs258324	AAGCAGAGGATGTGAGAAGG	AAGCATCTGGCCTGTCACTC
rs258323	CACGCCCAGCTAATTTTTTC	AGTCAGGAGATCTAGAGCAC
rs2075880	AAGTGCTGGGATTACAAGCG	AAAGCATTGGCCCAGTATCG
rs258322	TCTGAAACAGGGCAGAAACC	GGATGCTTACGTTTACCCAG
rs25832	TTTGGCAACAGAGTGAGACCC	AGCTTCCAGAATGACCTACG
rs164744	TCAGTCCCCACTCTGTGCAA	ACAGAGCAAAGTTGGGCACC
rs3833829	ATGCCCAGTGACACTCAGTC	CCTGCCCAGTTCAAATGAGG
AB	ATGGAGACTGCAGAGCCCTC	TGGTGTGGCCCAGCACATCA
rs164743	AAAAGTGCTTATTGGGCCGG	AACTGCCGACCTCAGGTGAT
rs164742	AACGAGCGAAACTCCGTCTC	TGATAGCAGGTGCTGCAGTG
rs187282	TGGGAACCCCTGAGCTTTTA	GTTGGAAGCACAAATTCGGC
rs465507	AAGCACCCACCTCAATACGG	TCCGAGTTGGGACAGGTTTC
rs2162943	TGAGCTCAGGAACCAGGTGAC	CAGCATCGACATGTGGTGAG
AC	TGACTGCAGCCAGACCTTTG	TGCCTGTCCTTCACAGTGTC
rs1946482	TCCTCGCTATGTTGGAAATG	ACCACAACTCAAAGACAGCG
rs8404	AAGGTATGGGGTGGGAGC	GCCTCCTGTTGGGTCCTC
rs1045814	AGAGGGGCTGTCACAGTGGA	TGGGTCCAGTGGTAATGGTG
rs4247353	AGCTGCTGTGACACCCAAGG	AAGCTCTGCTGGAGCCAATC
rs462769	AAGCCAGGTCAGCCGTGCA	TCCTCAAGGGCCTGTTGGTG
rs3803690	ACACTCGTGTGGAGAATCCC	TCCCTGCAGTACGGAGTACG
rs3751696	ATACAGAGAGTCCCACCTCC	TCTGGTTGCCTTGTCCCTGG
rs9972864	TACAAGCGTGAGCCACTGTG	ACTGTACTCCAGACAGAGCG
rs10567226	TCCATCCTGGTGACAGAGTG	ACAGCCGTGGGACGGTAGAA
rs417414	CCACACCCAGCTCATTTTTG	GAGATTGACACCAGCCTAAC
rs154661	CCCTTGAGGCCTCCCAGGG	GGCCAGGAAGCAGCAGAAC
rs4785704	CACGCCCGGCTGATTTTTTG	CACGAGGTCAGGAGATCAAG
rs4785584	TAATCCCAGCACTTTGGGAG	GGTTTCACCGTGTTAGCCAG
rs4785585	CCTGTAATCCCAGCACTTTG	AGGATGGTCTTGATCTCCTG
rs4785705	AGGATGGTCTTGATCTCCTG	CCTGTAATCCCAGCACTTTG
rs4785586	ATCTCCTGACCTCGTGATCC	AAATCCTACAAATGGCCGGG
rs4785587	AACAAATCCTGGCGTGGGAG	GGATACAGCTGAGCCAGGAC
rs2016968	GACACTTCTGTCTCCCTATG	AAAAGCAGTAGCTGTGGACC
rs3751693	ATCAGGTACCTGCATGGATG	GCAGACACTACCTTCTGGAG
rs3809646	AAAAATGCACGAACGCACGG	TAGAGGAGATGTAGCAGGAG
rs4785590	ACCTCTTGCTGGTGCTAGAC	CTAGAGCAGTGGAGACATTC
rs2099105	ATCAGAGGCTGCATAGCACC	GATGACTAGAAGGGAGACTG
rs4785708	TGTTCATGCTGAAGCTGCTG	GAAAAGAGAAACGGGAGCAG
rs4785710	TTGTTCCCAGGAGTCATGGC	AGGTGTCCTGGGATTCAGAC
rs4785591	ATTGGGTGGCCCCTTGTTTG	GAGGAGGTGAGTGGTCATTG
rs4785592	ATTGGGTGGCCCCTTGTTTG	GAGGAGGTGAGTGGTCATTG
rs4785593	CGCACTGAGAAGAACTGTTG	GGCTAGGTCATGAAAACCAG
rs4785711	TAAAGAGTGCATTGAGGCCG	AACTCCTGACCTCATGATCC
rs4785712	CAAAGTGCTGGGATTACAGG	AACAACATGAGACCCTGTCG
rs4785713	AAGTGAGCCTCTCACCTCAG	TAGTTTACACTGCCGAGTCC
rs4785714	CTGTGAAGGACTGAAAGCTC	TGAGAGCAGTGGTGAGAGAA
rs4785594	GCACTTGTGGTTCCTTTCTG	TATCGTGGTGAAGAAGTTCC
rs3803689	GTGTTTCTGCAGCCTAACTC	TAGGACTGCTTCAGGTCTCG
rs4785715	TGAAGCAGTCCTAGCCAGTG	AAGAAACTTCTAGACCCCCC
rs3764258	TTCATGCCTTCTGCCTTGCC	ATCTCAGCCTTCCAAAGTGC
rs4785716	ATGAAGGCACACCAGCTCTG	TAATGACACGACCTACACAC
rs4785717	ATGAAGGCACACCAGCTCTG	CGGTCTTAATGACACGACCT
rs2077001	AGGCTAAGGCAGTAGGATTG	TTTGGTAAAGACGGCCTCAC
rs2377049	CACAAAGTGCTCAATCCCAG	ACCATATTGATTGGGCTGGG
rs2003522	CTGAGATTGGGCTGTTGCAC	CTTGGCATTTTACTCTACGC
rs1230	TCTCCTCGACTGCTTTAGTG	CCAGTGGTTTATTTTCCCGC
rs1800359	AAAGAGCTTCTCACACGTGG	GGCAGCTGTCAATTCTCATG
rs1061646	ATAGGCAGAGATGTCCAGAG	AAAAAGCGAAAGGCAGCAGC
rs1800358	TTCTCTCTGTCCCAGTTTCC	AATCGCAAAGTGCAGTGCAG
rs2286392	CAGGTCCACGTGAGAGTGTG	CAGTCAGCAGCTCTCAGAAC
rs2074904	TGTAGTGGCCTGTAGGAGCA	AGATGAGGGTGGCTGAGATG
rs2074903	CGTCAATTAAGGCTCAAAGC	CCTTCTCCAAATTCCACGTC

	TABLE 23
	Term
	dbSNP rs #	Extend Primer	Mix
	rs460879	ACCAACCCCACGCTCTG	ACT
	rs460984	CTTGTGAAGCTGAGTGG	ACT
	rs2437957	CGGAAGGTGGATCAGCG	ACG
	rs3815949	TCCAGCTGCTTTCCCCC	ACT
	rs2437956	TCGGCCTCCCAAAGAGC	ACG
	rs2437955	ACAGGCGTGAGCCACCG	CGT
	rs2434872	GCGGATCCTATCATTTTTA	ACT
	rs467357	GTGCAGCCCAGAATGGTTTC	ACG
	rs258337	AAAGAATCCCAAGGGAC	CGT
	rs258336	CTGGGCCAATTTAAAAGT	ACT
	rs258335	TTTCCAGCGGTACAGTC	ACT
	rs164752	GCTCAGGCCTGTAACCC	ACG
	rs154663	GTGCGATCTCGCTCACC	ACT
	rs164753	TCCTAACAGCTGCCACA	ACT
	rs258332	CCATAATTCAATCACCTCC	ACG
	rs2010623	GCCAACGTGGCGAAACC	ACG
	rs187283	GGCGCACACCTGTAGTC	ACG
	rs258330	AAGAGAAATGGAACACTTC	ACT
	rs258328	CAGGCAGATCACTTGAG	ACG
	rs459920	CCTCCCTCTTCCTCATTCC	ACT
	rs166297	CTCTTCTAAGCCCATTC	ACG
	rs258318	GACTTATTTCATCTTCCTCA	ACT
	rs258317	ATTCACGCCTGTAATCC	ACG
	rs171805	AGGGCTCCTTGGTCTAG	ACG
	rs2081984	GGCACCTGGGTGACTTG	ACG
	rs464586	CTAAGCACTGAGCGATA	ACG
	rs460319	CTGCACTAAGCACTGAG	CGT
	rs447735	TTCTGCTATAGGTCTCTGACA	ACT
	rs2377058	CCACAAAGCTGTAAAACA	ACT
	rs604868	CGCCGTGAGAAACTGCAG	ACG
	rs2118193	GCAGTGAGCTGGGATCG	ACG
	rs467035	AAGAAGGCACCAGACTC	ACT
	rs2115401	CCTTGAGCACTGGAGTC	ACG
	rs417323	ACACTTTTTATATTTGACAAACTT	ACT
	rs2377233	GCTAGGATTACAGGTGT	ACT
	AA	TTGGCCTTTTGCAGTACCTC	ACT
	rs9746114	GGCTGTGGGCTGTTGGGAA	ACT
	rs3751700	CAGCTATGTCAGCATTC	ACG
	rs2277905	CTCTCACCTGGAGGACC	ACT
	rs397891	AAGCTCCTTCCCGGGCTTC	ACT
	rs3794638	GGCTCAGGGATGCCTCG	CGT
	rs3794637	TGTGGGGAGAATTTACA	ACG
	rs258324	TGATGGCCTAGTCTCAA	CGT
	rs258323	TAGAGCACCCTGACTAA	ACT
	rs2075880	CCACCTTTTCTCATCAGA	ACT
	rs258322	ACCCAGAAATGGTACAA	ACG
	rs258321	GTGGTGTTTTTGGTTTTTT	ACG
	rs164744	CCCCTGCCCAGTTCAAA	ACT
	rs3833829	CCGAGACGCGTTCCCCC	ACT
	AB	CCCTCCTGGCAGACAGCT	ACT
	rs164743	GTGCTGGGATTACAGGC	ACT
	rs164742	CCCCACCTCAGGGAGAA	ACG
	rs187282	CACAAATTCGGCTGAGGCCT	ACT
	rs465507	GGACAGGTTTCCAGGCCA	ACT
	rs2162943	CATGTGGTGAGGAGATA	ACG
	AC	CCTGCCAGTGTGAGGCAC	ACT
	rs1946482	CACCCACCACTCCTCCC	ACT
	rs8404	CGAGACTACCAGGAGAGCCC	ACG
	rs1045814	CTGTCACAGTGGATGCACC	ACG
	rs4247353	CTGACCTGGCTTCGGGG	ACT
	rs462769	ACCCCAAGCTCTGCTGG	ACT
	rs3803690	GAGTACGGGGCTCAGGA	ACT
	rs3751696	GGTTGGCCTGGACTCTCCA	CGT
	rs9972864	GCCACTGTGCCCGGCCTA	ACT
	rs10567226	GACTCCGTCTCAAAAAAAAAAAAA	ACT
	rs417414	CAACATGGTGAAACCCC	ACT
	rs154661	GTCCAAACCAGGGCTGTCC	ACT
	rs4785704	ATCAAGACCATCCTGGC	ACG
	rs4785584	GTTAGCCAGGATGGTCT	ACG
	rs4785585	CTCCTGACCTCGTGATC	ACG
	rs4785705	CAGCACTTTGGGAGGCC	ACT
	rs4785586	CCCAGCACTTTGGGAGG	ACG
	rs4785587	TGAGCCAGGACGTTCCC	ACT
	rs2016968	CTCTGTGCTTGCACCCT	ACT
	rs3751693	GTGTCCTTCTGTTCGTT	ACG
	rs3809646	CCAAAATCCGAGTGACG	ACT
	rs4785590	TGCTGAAAACCCTGCCC	ACT
	rs2099105	CTCAAGTTCTCCCCACC	ACT
	rs4785708	GAGCAGTGGAGGAGGCC	ACG
	rs4785710	GGATTCAGACTCAACCC	ACT
	rs4785591	AGTGGTCATTGTGGGAA	ACG
	rs4785592	TGGTCATTGTGGGAACG	ACT
	rs4785593	GGGACAGGGAGAGAAGG	ACG
	rs4785711	GGGATTACAGGCGTGAG	ACT
	rs4785712	AGAGTGCATTGAGGCCG	ACT
	rs4785713	TCATGTTGGCAGTCCCA	ACT
	rs4785714	GGTGAGAGAATCCGTAT	CGT
	rs4785594	GAAGTTCCTTTCTGTTCTT	ACT
	rs3803689	TCAAAGTGTCCTTGGGC	ACT
	rs4785715	CAAGTGAAAGTCTGGCC	ACG
	rs3764258	GATTACAGGTGTGAGCA	ACT
	rs4785716	GACCTACACACATGTGAA	ACT
	rs4785717	GACACGACCTACACACA	ACG
	rs2077001	ACGGCCTCACTATGTTG	ACG
	rs2377049	CTGGTCTTGAACTGACT	ACT
	rs2003522	TCTTGCTCTGTTGCCCA	ACT
	rs1230	CGCAAACGCTGAGTGACT	ACG
	rs1800359	CAATTCTCATGTCCCCCAC	ACT
	rs1061646	GGTCTGCAACACCAAGAA	ACT
	rs1800358	CCAGTCCGGGTTGGGTGC	ACG
	rs2286392	TCAGAACGCCAGGATGC	ACG
	rs2074904	CCTCCGCTGCCCCAGCC	ACT
	rs2074903	CCATGAGTGTGGGTAATAAACT	ACT

Genetic Analysis

Allelotyping results are shown for female (F) and male (M) cases and controls in Table 24 and Table 25, respectively. Allele frequency is noted in the fourth and fifth columns for melanoma pools and control pools, respectively.

TABLE 24
Females
								Melanoma
	Chromo-	Chromosome		Female	Female	F	Odds	Associated
dbSNP rs#	some	Position	Alleles	Case AF	Control AF	p-Value	Ratio	Allele
rs460879	16	89456684	T/C	T = 0.492	T = 0.595	0.037	1.520	C
				C = 0.508	C = 0.405
rs460984	16	89456969	T/C	T = 0.780	T = 0.846	0.043	1.552	C
				C = 0.219	C = 0.153
rs2437957	16	89459443	C/T	C = 0.501	C = 0.508	0.849	1.026	T
				T = 0.498	T = 0.491
rs3815949	16	89459711	C/G	C = 0.002	C = 0.043	0.001	18.006	G
				G = 0.998	G = 0.957
rs2437956	16	89460046	G/A	G = 0.754	G = 0.756	0.962	1.009	A
				A = 0.245	A = 0.243
rs2437955	16	89460070	G/T	G = 0.846	G = 0.753	0.016	0.554	G
				T = 0.153	T = 0.246
rs2434872	16	89460710	C/G	C = 0.530	C = 0.546	0.620	1.069	G
				G = 0.469	G = 0.453
rs467357	16	89461192	G/A	G = 0.649	G = 0.659	0.779	1.044	A
				A = 0.350	A = 0.340
rs258337	16	89464505	A/T	A = 0.571	A = 0.643	0.047	1.351	T
				T = 0.428	T = 0.356
rs258336	16	89464626	T/G	T = 0.618	T = 0.555	0.093	0.771	T
				G = 0.381	G = 0.444
rs258335	16	89464739	A/G	A = 0.769	A = 0.752	0.602	0.911	A
				G = 0.230	G = 0.247
rs164752	16	89466185	G/A	G = 0.128	G = 0.057	0.003	0.411	G
				A = 0.871	A = 0.942
rs154663	16	89469830	T/C	T = 0.196	T = 0.208	0.679	1.082	C
				C = 0.803	C = 0.791
rs164753	16	89471390	T/C	T = 0.864	T = 0.832	0.219	0.780	T
				C = 0.135	C = 0.167
rs258332	16	89471478	G/A	G = 0.950	G = 0.941	0.681	0.840	G
				A = 0.050	A = 0.059
rs2010623	16	89472820	C/T	C = 0.961	C = 0.978	0.473	1.810	T
				T = 0.039	T = 0.022
rs187283	16	89473131	G/A	G = 0.955	G = 0.973	0.470	1.690	A
				A = 0.045	A = 0.027
rs258330	16	89473369	T/G	T = 0.583	T = 0.626	0.244	1.199	G
				G = 0.416	G = 0.373
rs258328	16	89474109	C/T	C = 0.870	C = 0.906	0.340	1.430	T
				T = 0.130	T = 0.094
rs459920	16	89474622	T/C	T = 0.723	T = 0.687	0.254	0.841	T
				C = 0.276	C = 0.312
rs166297	16	89474980	G/A	G = 0.920	G = 0.908	0.574	0.864	G
				A = 0.079	A = 0.091
rs258318	16	89475845	T/C	T = 0.204	T = 0.250	0.116	1.300	C
				C = 0.795	C = 0.749
rs258317	16	89476033	C/T	C = 0.978	C = 0.981	0.853	1.123	T
				T = 0.022	T = 0.019
rs171805	16	89477409	G/A	G = 0.979	G = 0.954	0.239	0.450	G
				A = 0.021	A = 0.046
rs2081984	16	89477721	C/T	C = 0.874	C = 0.870	0.830	0.958	C
				T = 0.125	T = 0.129
rs464586	16	89477883	C/T	C = 0.354	C = 0.157	˜0.001	0.340	C
				T = 0.645	T = 0.842
rs460319	16	89477888	G/T	G = 0.166	G = 0.213	0.103	1.362	T
				T = 0.833	T = 0.786
rs447735	16	89478144	A/G	A = 0.699	A = 0.660	0.224	0.833	A
				G = 0.300	G = 0.339
rs2377058	16	89478626	T/C	T = 0.780	T = 0.796	0.609	1.100	C
				C = 0.220	C = 0.204
rs604868	16	89479972	G/A	G = 0.118	G = 0.116	0.912	0.976	G
				A = 0.881	A = 0.883
rs2118193	16	89483698	C/T	C = 0.814	C =
				T = 0.186	T =
rs467035	16	89484080	C/G	C = 0.647	C = 0.632	0.653	0.937	C
				G = 0.352	G = 0.367
rs2115401	16	89484404	C/T	C = 0.660	C = 0.660	0.999	1.000	C
				T = 0.339	T = 0.339
rs417323	16	89490072	T/G	T = 0.634	T = 0.641	0.877	1.027	G
				G = 0.365	G = 0.358
rs2377233	16	89490697	C/G	C = 0.891	C = 0.845	0.110	0.668	C
				G = 0.108	G = 0.154
AA	16	89493039	G/C	G = 0.077	G = 0.042	0.052	0.535	G
ds000175				C = 0.922	C = 0.957
rs9746114	16	89495122	C/G	C = 0.953	C = 0.948	0.763	0.897	C
				G = 0.046	G = 0.051
rs3751700	16	89495989	G/A	G = 0.974	G = 0.953	0.524	0.544	G
				A = 0.025	A = 0.046
rs2277905	16	89496296	A/G	A = 0.919	A = 0.886	0.160	0.687	A
				G = 0.080	G = 0.113
rs397891	16	89496826	C/G	C = 0.695	C =
				G = 0.305	G =
rs3794638	16	89497231	G/T	G = 0.924	G = 0.901	0.489	0.751	G
				T = 0.075	T = 0.098
rs3794637	16	89497365	G/A	G =	G =
				A =	A =
rs258324	16	89498050	C/A	C = 0.897	C = 0.891	0.777	0.934	C
				A = 0.102	A = 0.108
rs258323	16	89498489	C/G	C = 0.823	C = 0.779	0.225	0.760	C
				G = 0.176	G = 0.220
rs2075880	16	89499011	A/G	A = 0.623	A = 0.695	0.027	1.380	G
				G = 0.376	G = 0.304
rs258322	16	89499698	C/T	C = 0.909	C = 0.950	0.090	1.903	T
				T = 0.090	T = 0.049
rs258321	16	89500268	C/T	C =	C =
				T =	T =
rs164744	16	89500563	A/C	A =	A =
				C =	C =
rs3833829	16	89500576	A/—	A = 0.103	A = 0.140	0.123	1.411	—
				— = 0.896	— = 0.859
AB	16	89500994	T/C	T = 0.526	T = 0.465	0.064	0.783	T
ds000276				C = 0.473	C = 0.534
rs164743	16	89501226	A/G	A = 0.161	A = 0.244	0.036	1.681	G
				G = 0.838	G = 0.755
rs164742	16	89501520	C/T	C = 0.652	C = 0.700	0.128	1.247	T
				T = 0.347	T = 0.299
rs187282	16	89502768	T/C	T = 0.060	T = 0.036	0.226	0.588	T
				C = 0.939	C = 0.963
rs465507	16	89504287	C/G	C = 0.194	C = 0.151	0.112	0.735	C
				G = 0.805	G = 0.848
rs2162943	16	89504447	G/A	G = 0.796	G = 0.833	0.172	1.281	A
				A = 0.203	A = 0.166
AC	16	89504754	G/C	G = 0.238	G = 0.175	0.105	0.681	G
ds000173				C = 0.761	C = 0.824
rs1946482	16	89506205	T/C	T = 0.900	T = 0.892	0.714	0.915	T
				C = 0.099	C = 0.107
rs8404	16	89506442	C/T	C = 0.227	C = 0.141	0.006	0.563	C
				T = 0.772	T = 0.858
rs1045814	16	89506710	G/A	G = 0.659	G = 0.664	0.864	1.025	A
				A = 0.340	A = 0.335
rs4247353	16	89507009	T/C	T = 0.376	T = 0.418	0.341	1.193	C
				C = 0.623	C = 0.581
rs462769	16	89507058	A/G	A = 0.665	A = 0.687	0.540	1.106	G
				G = 0.334	G = 0.312
rs3803690	16	89507154	C/G	C = 0.668	C = 0.702	0.326	1.167	G
				G = 0.331	G = 0.297
rs3751696	16	89507414	A/T	A =	A =
				T =	T =
rs9972864	16	89508992	A/G	A = 0.048	A = 0.050	0.872	1.058	G
				G = 0.951	G = 0.949
rs10567226	16	89509757	TTT/—	TTT = 0.916	TTT = 0.930	0.430	1.233	—
				— = 0.083	— = 0.069
rs417414	16	89509943	A/G	A = 0.297	A = 0.273		0.886	A
				G = 0.702	G = 0.726
rs154661	16	89510366	G/C	G = 0.045	G = 0.081	0.148	1.838	C
				C = 0.954	C = 0.918
rs4785704	16	89516165	G/A	G = 0.058	G = 0.056	0.899	0.950	G
				A = 0.942	A = 0.944
rs4785584	16	89516179	C/T	C = 0.875	C = 0.860	0.577	0.880	C
				T = 0.125	T = 0.140
rs4785585	16	89516200	C/T	C = 0.797	C = 0.801	0.882	1.030	T
				T = 0.203	T = 0.199
rs4785705	16	89516209	T/C	T = 0.513	T = 0.482	0.383	0.880	T
				C = 0.487	C = 0.518
rs4785586	16	89516211	G/A	G =	G =
				A =	A =
rs4785587	16	89516414	A/G	A = 0.758	A = 0.714	0.134	0.795	A
				G = 0.241	G = 0.285
rs2016968	16	89516701	C/G	C = 0.655	C = 0.639	0.649	0.931	C
				G = 0.344	G = 0.360
rs3751693	16	89518191	C/T	C = 0.377	C = 0.367	0.816	0.960	C
				T = 0.623	T = 0.633
rs3809646	16	89530650	A/G	A = 0.779	A = 0.746	0.282	0.831	A
				G = 0.220	G = 0.253
rs4785590	16	89533962	G/C	G = 0.657	G = 0.621	0.333	0.856	G
				C = 0.342	C = 0.378
rs2099105	16	89537350	A/G	A = 0.439	A = 0.386	0.117	0.802	A
				G = 0.560	G = 0.613
rs4785708	16	89540364	C/T	C = 0.690	C = 0.640	0.117	0.799	C
				T = 0.309	T = 0.359
rs4785710	16	89540551	T/C	T = 0.553	T = 0.598	0.251	1.203	C
				C = 0.446	C = 0.401
rs4785591	16	89541308	C/T	C = 0.716	C = 0.755	0.200	1.225	T
				T = 0.283	T = 0.244
rs4785592	16	89541310	C/G	C = 0.031	C = 0.010	0.037	0.268	C
				G = 0.969	G = 0.990
rs4785593	16	89541422	C/T	C = 0.396	C = 0.355	0.218	0.843	C
				T = 0.603	T = 0.644
rs4785711	16	89541741	C/G	C = 0.977	C = 0.983	0.730	1.376	G
				G = 0.023	G = 0.017
rs4785712	16	89541749	G/C	G = 0.239	G = 0.223	0.584	0.914	G
				C = 0.760	C = 0.776
rs4785713	16	89541893	G/C	G = 0.581	G = 0.527	0.113	0.804	G
				C = 0.418	C = 0.472
rs4785714	16	89542199	C/A	C = 0.718	C = 0.631	0.011	0.673	C
				A = 0.281	A = 0.368
rs4785594	16	89542311	C/G	C = 0.708	C = 0.753	0.210	1.256	G
				G = 0.291	G = 0.246
rs3803689	16	89543853	A/G	A = 0.681	A = 0.623	0.069	0.776	A
				G = 0.318	G = 0.376
rs4785715	16	89543930	G/A	G = 0.631	G = 0.642	0.738	1.047	A
				A = 0.368	A = 0.357
rs3764258	16	89544809	C/G	C = 0.903	C = 0.910	0.760	1.077	G
				G = 0.096	G = 0.089
rs4785716	16	89544922	T/C	T = 0.859	T = 0.956	˜0.001	3.627	C
				C = 0.140	C = 0.043
rs4785717	16	89544928	G/A	G = 0.600	G = 0.571	0.367	0.887	G
				A = 0.399	A = 0.428
rs2077001	16	89545885	C/T	C = 0.412	C = 0.460	0.160	1.217	T
				T = 0.587	T = 0.539
rs2377049	16	89546763	A/C	A = 0.772	A = 0.792	0.541	1.127	C
				C = 0.227	C = 0.207
rs2003522	16	89547081	C/G	C = 0.387	C = 0.345	0.224	0.833	C
				G = 0.612	G = 0.654
rs1230	16	89548650	C/T	C = 0.645	C = 0.666	0.527	1.098	T
				T = 0.354	T = 0.333
rs1800359	16	89549056	A/G	A = 0.705	A = 0.776	0.015	1.448	G
				G = 0.294	G = 0.223
rs1061646	16	89549772	T/C	T = 0.387	T = 0.355	0.308	0.869	T
				C = 0.612	C = 0.644
rs1800358	16	89553114	C/T	C = 0.199	C = 0.199	0.987	1.003	C
				T = 0.800	T = 0.800
rs2286392	16	89553344	C/T	C = 0.266	C = 0.270	0.881	1.023	T
				T = 0.733	T = 0.729
rs2074904	16	89555341	T/C	T = 0.914	T = 0.919	0.807	1.063	C
				C = 0.085	C = 0.080
rs2074903	16	89555458	A/G	A = 0.921	A = 0.906	0.507	0.829	A
				G = 0.078	G = 0.093

TABLE 25
Males
								Melanoma
	Chromo-	Chromosome		Male	Male	M	Odds	Associated
dbSNP rs#	some	Position	Alleles	Case AF	Control AF	p-Value	Ratio	Allele
rs460879	16	89456684	T/C	T = 0.532	T =
				C = 0.468	C =
rs460984	16	89456969	T/C	T =	T =
				C =	C =
rs2437957	16	89459443	C/T	C = 0.541	C = 0.512	0.430	0.890	C
				T = 0.458	T = 0.487
rs3815949	16	89459711	C/G	C = 0.015	C = 0.002	0.207	0.108	C
				G = 0.985	G = 0.998
rs2437956	16	89460046	G/A	G = 0.780	G = 0.723	0.081	0.737	G
				A = 0.219	A = 0.276
rs2437955	16	89460070	G/T	G = 0.886	G = 0.825	0.037	0.605	G
				T = 0.113	T = 0.174
rs2434872	16	89460710	C/G	C = 0.544	C = 0.585	0.352	1.183	G
				G = 0.455	G = 0.414
rs467357	16	89461192	G/A	G = 0.654	G = 0.650	0.908	0.982	G
				A = 0.345	A = 0.349
rs258337	16	89464505	A/T	A = 0.577	A = 0.654	0.028	1.385	T
				T = 0.422	T = 0.345
rs258336	16	89464626	T/G	T = 0.588	T = 0.522	0.068	0.765	T
				G = 0.411	G = 0.477
rs258335	16	89464739	A/G	A = 0.777	A = 0.791	0.709	1.085	G
				G = 0.222	G = 0.208
rs164752	16	89466185	G/A	G = 0.101	G = 0.054	0.036	0.511	G
				A = 0.898	A = 0.945
rs154663	16	89469830	T/C	T = 0.172	T = 0.207	0.270	1.252	C
				C = 0.827	C = 0.792
rs164753	16	89471390	T/C	T = 0.902	T = 0.808	˜0.001	0.454	T
				C = 0.097	C = 0.191
rs258332	16	89471478	G/A	G = 0.952	G = 0.933	0.383	0.700	G
				A = 0.048	A = 0.067
rs2010623	16	89472820	C/T	C = 0.971	C = 0.952	0.535	0.590	C
				T = 0.029	T = 0.048
rs187283	16	89473131	G/A	G = 0.967	G = 0.971	0.904	1.130	A
				A = 0.033	A = 0.029
rs258330	16	89473369	T/G	T = 0.632	T = 0.606	0.456	0.895	T
				G = 0.367	G = 0.393
rs258328	16	89474109	C/T	C = 0.855	C = 0.782	0.062	0.610	C
				T = 0.145	T = 0.218
rs459920	16	89474622	T/C	T = 0.718	T = 0.686	0.317	0.857	T
				C = 0.281	C = 0.313
rs166297	16	89474980	G/A	G = 0.944	G = 0.916	0.171	0.643	G
				A = 0.055	A = 0.083
rs258318	16	89475845	T/C	T = 0.149	T = 0.223	0.027	1.633	C
				C = 0.850	C = 0.776
rs258317	16	89476033	C/T	C = 0.974	C = 0.978	0.820	1.176	T
				T = 0.025	T = 0.021
rs171805	16	89477409	G/A	G =	G = 0.964
				A =	A = 0.036
rs2081984	16	89477721	C/T	C = 0.860	C = 0.845	0.552	0.887	C
				T = 0.139	T = 0.154
rs464586	16	89477883	C/T	C = 0.304	C = 0.132	˜0.001	0.350	C
				T = 0.695	T = 0.867
rs460319	16	89477888	G/T	G = 0.156	G = 0.230	0.010	1.617	T
				T = 0.843	T = 0.769
rs447735	16	89478144	A/G	A = 0.686	A = 0.654	0.327	0.864	A
				G = 0.313	G = 0.345
rs2377058	16	89478626	T/C	T = 0.840	T = 0.840	0.609	1.000	T
				C = 0.160	C = 0.160
rs604868	16	89479972	G/A	G = 0.103	G = 0.109	0.791	1.063	A
				A = 0.896	A = 0.890
rs2118193	16	89483698	C/T	C =	C =
				T =	T =
rs467035	16	89484080	C/G	C = 0.662	C = 0.620	0.254	0.834	C
				G = 0.337	G = 0.379
rs2115401	16	89484404	C/T	C = 0.672	C = 0.651	0.564	0.909	C
				T = 0.327	T = 0.348
rs417323	16	89490072	T/G	T = 0.625	T = 0.663	0.444	1.183	G
				G = 0.374	G = 0.336
rs2377233	16	89490697	C/G	C = 0.899	C = 0.833	0.038	0.562	C
				G = 0.100	G = 0.166
AA	16	89493039	G/C	G = 0.049	G = 0.065	0.405	1.335	C
				C = 0.950	C = 0.934
rs9746114	16	89495122	C/G	C = 0.971	C = 0.942	0.166	0.471	C
				G = 0.028	G = 0.057
rs3751700	16	89495989	G/A	G = 0.987	G = 0.941	0.142	0.212	G
				A = 0.013	A = 0.059
rs2277905	16	89496296	A/G	A = 0.955	A = 0.934	0.332	0.663	A
				G = 0.044	G = 0.065
rs397891	16	89496826	C/G	C = 0.608	C =
				G = 0.392	G =
rs3794638	16	89497231	G/T	G =	G =
				T =	T =
rs3794637	16	89497365	G/A	G = 0.874	G = 0.832	0.189	0.716	G
				A = 0.125	A = 0.167
rs258324	16	89498050	C/A	C = 0.916	C = 0.893	0.334	0.770	C
				A = 0.083	A = 0.106
rs258323	16	89498489	C/G	C = 0.816	C = 0.785	0.300	0.824	C
				G = 0.183	G = 0.214
rs2075880	16	89499011	A/G	A = 0.596	A = 0.707	0.001	1.631	G
				G = 0.403	G = 0.292
rs258322	16	89499698	C/T	C = 0.908	C = 0.954	0.014	2.128	T
				T = 0.091	T = 0.045
rs258321	16	89500268	C/T	C = 0.606	C = 0.735	0.003	1.801	T
				T = 0.393	T = 0.264
rs164744	16	89500563	A/C	A = 0.715	A = 0.573	˜0.001	0.536	A
				C = 0.284	C = 0.426
rs3833829	16	89500576	A/—	A = 0.103	A = 0.143	0.152	1.451	—
				— = 0.896	— = 0.856
AB	16	89500994	T/C	T = 0.492	T = 0.425	0.078	0.764	T
				C = 0.507	C = 0.574
rs164743	16	89501226	A/G	A =	A =
				G =	G =
rs164742	16	89501520	C/T	C = 0.678	C = 0.760	0.015	1.501	T
				T = 0.321	T = 0.239
rs187282	16	89502768	T/C	T = 0.066	T = 0.048	0.625	0.713	T
				C = 0.933	C = 0.951
rs465507	16	89504287	C/G	C = 0.218	C = 0.171	0.106	0.739	C
				G = 0.781	G = 0.828
rs2162943	16	89504447	G/A	G = 0.822	G = 0.797	0.470	0.851	G
				A = 0.177	A = 0.202
AC	16	89504754	G/C	G = 0.253	G = 0.219	0.325	0.826	G
				C = 0.746	C = 0.780
rs1946482	16	89506205	T/C	T = 0.896	T = 0.878	0.512	0.836	T
				C = 0.103	C = 0.121
rs8404	16	89506442	C/T	C = 0.195	C = 0.121	0.017	0.567	C
				T = 0.804	T = 0.878
rs1045814	16	89506710	G/A	G = 0.637	G = 0.675	0.328	1.183	A
				A = 0.362	A = 0.324
rs4247353	16	89507009	T/C	T =	T =
				C =	C =
rs462769	16	89507058	A/G	A = 0.663	A = 0.719	0.103	1.300	G
				G = 0.336	G = 0.280
rs3803690	16	89507154	C/G	C = 0.687	C = 0.690	0.931	1.016	G
				G = 0.312	G = 0.309
rs3751696	16	89507414	A/T	A = 0.725	A = 0.698	0.480	0.877	A
				T = 0.274	T = 0.301
rs9972864	16	89508992	A/G	A = 0.047	A = 0.049	0.930	1.038	G
				G = 0.952	G = 0.950
rs10567226	16	89509757	TTT/—	TTT = 0.925	TTT = 0.936	0.609	1.185	—
				— = 0.074	— = 0.063
rs417414	16	89509943	A/G	A = 0.287	A = 0.235	˜0.001	0.766	A
				G = 0.712	G = 0.764
rs154661	16	89510366	G/C	G = 0.025	G = 0.017	0.728	0.655	G
				C = 0.975	C = 0.983
rs4785704	16	89516165	G/A	G = 0.049	G = 0.045	0.855	0.920	G
				A = 0.951	A = 0.955
rs4785584	16	89516179	c/t	C = 0.894	C = 0.869	0.336	0.780	C
				T = 0.106	T = 0.131
rs4785585	16	89516200	c/t	C = 0.810	C = 0.811	0.977	1.010	T
				T = 0.190	T = 0.189
rs4785705	16	89516209	T/C	T = 0.500	T = 0.481	0.621	0.930	T
				C = 0.500	C = 0.519
rs4785586	16	89516211	G/A	G = 0.804	G = 0.852	0.163	1.408	A
				A = 0.195	A = 0.147
rs4785587	16	89516414	A/G	A = 0.742	A = 0.689	0.097	0.770	A
				G = 0.257	G = 0.310
rs2016968	16	89516701	C/G	C = 0.667	C = 0.635	0.376	0.865	C
				G = 0.332	G = 0.364
rs3751693	16	89518191	C/T	C = 0.390	C = 0.382	0.853	0.970	C
				T = 0.610	T = 0.618
rs3809646	16	89530650	A/G	A = 0.786	A = 0.739	0.197	0.769	A
				G = 0.213	G = 0.260
rs4785590	16	89533962	G/C	G = 0.643	G = 0.605	0.280	0.852	G
				C = 0.356	C = 0.394
rs2099105	16	89537350	A/G	A = 0.420	A = 0.365	0.112	0.794	A
				G = 0.579	G = 0.634
rs4785708	16	89540364	C/T	C = 0.674	C = 0.600	0.025	0.725	C
				T = 0.325	T = 0.399
rs4785710	16	89540551	T/C	T = 0.572	T = 0.620	0.175	1.223	C
				C = 0.427	C = 0.379
rs4785591	16	89541308	C/T	C = 0.767	C = 0.768	0.954	1.010	T
				T = 0.232	T = 0.231
rs4785592	16	89541310	C/G	C = 0.022	C = 0.003	0.090	0.154	C
				G = 0.978	G = 0.997
rs4785593	16	89541422	C/T	C = 0.381	C = 0.340	0.221	0.839	C
				T = 0.618	T = 0.659
rs4785711	16	89541741	C/G	C = 0.982	C = 0.990	0.527	1.721	G
				G = 0.018	G = 0.010
rs4785712	16	89541749	G/C	G = 0.233	G = 0.186	0.129	0.756	G
				C = 0.766	C = 0.813
rs4785713	16	89541893	G/C	G = 0.548	G = 0.483	0.061	0.772	G
				C = 0.451	C = 0.516
rs4785714	16	89542199	C/A	C = 0.659	C = 0.599	0.070	0.772	C
				A = 0.340	A = 0.400
rs4785594	16	89542311	C/G	C = 0.729	C = 0.752	0.491	1.129	G
				G = 0.270	G = 0.247
rs3803689	16	89543853	A/G	A = 0.637	A = 0.614	0.526	0.906	A
				G = 0.362	G = 0.385
rs4785715	16	89543930	G/A	G = 0.641	G = 0.658	0.625	1.074	A
				A = 0.358	A = 0.341
rs3764258	16	89544809	C/G	C = 0.917	C = 0.912	0.804	0.936	C
				G = 0.082	G = 0.087
rs4785716	16	89544922	T/C	T =	T =
				C =	C =
rs4785717	16	89544928	G/A	G = 0.599	G = 0.539	0.075	0.780	G
				A = 0.400	A = 0.460
rs2077001	16	89545885	C/T	C = 0.461	C = 0.474	0.703	1.056	T
				T = 0.538	T = 0.525
rs2377049	16	89546763	A/C	A = 0.777	A = 0.800	0.467	1.149	C
				C = 0.222	C = 0.199
rs2003522	16	89547081	C/G	C = 0.355	C = 0.315	0.309	0.837	C
				G = 0.644	G = 0.684
rs1230	16	89548650	C/T	C = 0.663	C = 0.672	0.774	1.043	T
				T = 0.336	T = 0.327
rs1800359	16	89549056	A/G	A = 0.755	A = 0.805	0.085	1.340	G
				G = 0.244	G = 0.194
rs1061646	16	89549772	T/C	T = 0.375	T = 0.332	0.261	0.830	T
				C = 0.624	C = 0.667
rs1800358	16	89553114	C/T	C = 0.204	C = 0.176	0.362	0.835	C
				T = 0.795	T = 0.823
rs2286392	16	89553344	C/T	C = 0.268	C = 0.286	0.582	1.094	T
				T = 0.731	T = 0.713
rs2074904	16	89555341	T/C	T = 0.931	T = 0.919	0.537	0.839	T
				C = 0.068	C = 0.080
rs2074903	16	89555458	A/G	A = 0.915	A = 0.914	0.943	0.981	A
				G = 0.084	G = 0.085

Allelotyping results were considered significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The assay failed for those SNPs in which the allele frequency is blank. The combined allelotyping p-values for males and females were plotted in FIG. 3A and separately for females and males in FIGS. 3B and 3C, respectively. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele frequency in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIGS. 3A, 3B and 3C can be determined by consulting Table 24 or 25. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.

To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line (or generally top-most curve, e.g., see peak in left-most graph just to the left of position 92150000) provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10⁻⁸ were truncated at that value.

Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.

Example 8

PCLO Proximal SNPs

It has been discovered that a polymorphic variation (rs1044639) in the untranslated region of a gene encoding presynaptic cytomatrix protein (PCLO) is associated with the occurrence of melanoma. See Table 3. Subsequently, seventy-six allelic variants located within or nearby the target gene were identified and subsequently allelotyped in melanoma case and control sample sets as described in Examples 1 and 2. Several SNPs, designated by SNP_ID “AD”, “AB”, and “AF” in column 1 of Table 26, are novel and were identified through SNP discovery methods using dye terminator sequencing. Methods of diedeoxynucleotide chain termination chemistry derived sequencing are described by Sanger et al. (Proc. Nat. Acad. Sci. USA 74, 5463-5467, 1997). Briefly, terminators are labeled with fluorescent dyes for automated detection. Fluorescein is measured by an argon ion laser in the sequencing instrument, which transfers light energy to a rhodamine acceptor dye. Each acceptor dye emits light at a characteristic wavelength for detection, identifying the nucleotide that terminated extension of the DNA fragment. Novel SNPs are identified when sequence from multiple samples are compared on one or more strands. The forward and reverse primers used to identify AD are CGTGCCTGATGGGATATACA and TTGGCTCAAAGGCAGCTAAT, respectively. The forward and reverse primers used to identify AE are TGCAACAACAAAGAGAACCA and TTCTCAGAGCCTTGTAGACTTCC, respectively. The forward and reverse primers used to identify AF are GTGAACTCATGCAGCAAGGA and GGTGGAACCTTTGCCAGTTA, respectively. The polymorphic variants are set forth in Table 26. The chromosome position provided in column four of Table 26 is based on Genome “Build 34” of NCBI's GenBank and dbSNP build “119”.

TABLE 26
					Allele
	Chromo-	Position in	Chromosome	Allele	Present in	IUPAC
dbSNP rs#	some	SEQ ID NO: 6	Position	Variants	SEQ ID NO: 6	Code
rs2158220	7	220	82023020	T/C	T	Y
rs1024465	7	1,365	82024165	G/A	A	R
rs4732483	7	5,798	82028598	T/C	C	Y
rs4732485	7	8,877	82031677	C/T	T	Y
rs1859176	7	17,309	82040109	C/T	C	Y
rs1859177	7	17,446	82040246	C/T	C	Y
rs2074401	7	18,837	82041637	A/G	A	R
rs4299948	7	19,159	82041959	T/G	G	K
rs4348435	7	20,902	82043702	G/A	A	R
rs4348436	7	20,923	82043723	G/C	C	S
rs4413718	7	21,066	82043866	G/C	G	S
rs985199	7	21,147	82043947	G/A	G	R
rs7791413	7	29,008	82051808	T/C	T	Y
rs2522830	7	32,354	82055154	G/A	G	R
rs2214414	7	33,363	82056163	T/C	C	Y
rs2189246	7	33,623	82056423	A/G	G	R
rs5885312	7	33,669	82056469	CTTAAGAA/—	T	N
rs3064840	7	33,672	82056472	AAGAACTT/—	T	N
rs2051791	7	33,989	82056789	C/T	T	Y
rs6467914	7	34,596	82057396	C/T	T	Y
rs2214415	7	34,733	82057533	G/A	A	R
rs2189247	7	36,496	82059296	C/A	C	M
rs3064869	7	36,669	82059469	—/ACA	C	N
rs2522831	7	37,351	82060151	T/C	T	Y
rs2715147	7	37,656	82060456	T/C	C	Y
rs3064870	7	38,055	82060855	—/TAAG	G	N
rs2715148	7	39,286	82062086	A/C	A	M
rs2522832	7	39,615	82062415	A/G	A	R
rs1044639	7	40,809	82063609	G/T	T	K
rs2715149	7	42,063	82064863	A/T	A	W
rs2522833	7	42,959	82065759	C/A	A	M
rs2247523	7	43,655	82066455	C/G	C	S
rs2371214	7	43,923	82066723	T/C	T	Y
rs2189248	7	44,556	82067356	T/C	T	Y
rs2715150	7	45,146	82067946	A/G	A	R
rs2715151	7	45,914	82068714	C/G	C	S
rs2371215	7	46,745	82069545	T/A	T	W
rs2715152	7	46,917	82069717	G/A	G	R
rs2715153	7	47,109	82069909	T/C	C	Y
rs972346	7	49,786	82072586	C/T	C	Y
rs2715154	7	50,117	82072917	G/T	G	K
rs2522834	7	50,197	82072997	T/C	C	Y
rs2023847	7	50,544	82073344	G/T	T	K
rs2715155	7	51,305	82074105	A/G	A	R
rs2715156	7	52,085	82074885	A/G	G	R
rs10715043	7	53,523	82076323	—/G	G	N
AD	7	53,843	82076643	C/G	C	S
rs2301722	7	54,485	82077285	A/C	A	M
rs2257207	7	57,435	82080235	A/T	A	W
rs2715157	7	57,625	82080425	A/G	A	R
rs2715158	7	58,857	82081657	G/C	G	S
rs2715159	7	60,659	82083459	A/G	A	R
rs2522835	7	60,747	82083547	A/T	T	W
rs2522836	7	62,304	82085104	C/A	C	M
AE	7	63,624	82086424	T/G	T	K
rs2522837	7	64,633	82087433	A/G	A	R
rs2522838	7	64,808	82087608	A/T	T	W
AF	7	65,039	82087839	AT/—	A	N
rs2522839	7	66,899	82089699	G/A	A	R
rs2522840	7	67,666	82090466	G/T	T	K
rs2522841	7	68,445	82091245	T/G	G	K
rs10555175	7	68,577	82091377	—/TTAT	T	N
rs10592258	7	68,581	82091381	—/TATTATT	T	N
rs2522842	7	68,913	82091713	G/T	G	K
rs6956848	7	68,950	82091750	G/T	T	K
rs2522843	7	68,973	82091773	C/A	C	M
rs2522844	7	69,343	82092143	T/C	C	Y
rs2522845	7	71,160	82093960	T/G	T	K
rs2715161	7	71,532	82094332	C/T	C	Y
rs6972720	7	71,926	82094726	C/T	T	Y
rs4377905	7	83,562	82106362	A/G	A	R
rs4579453	7	83,972	82106772	T/C	T	Y
rs4260846	7	84,087	82106887	C/A	C	M
rs1986481	7	85,934	82108734	A/T	A	W
rs4628206	7	86,594	82109394	A/T	T	W
rs2888017	7	89,454	82112254	A/G	G	R

Assay for Verifying and Allelotyping SNPs

The methods used to verify and allelotype the seventy-six proximal SNPs of Table 26 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 27 and Table 28, respectively.

TABLE 27
dbSNP rs #	Forward PCR primer	Reverse PCR primer
rs2158220	GGGCAGGAGAGAGATTCTAT	CCACAGCCCTTATTACAGTC
rs1024465	AGAGATTGTGTTAAGGCATC	CAAGCAAAACTCTTCTAAAG
rs4732483	CCCACCAAGACTGTAAAAGC	CAGGAAACAACAGATGCTGG
rs4732485	AAGTTCTTCCTGACAGCTTC	AGGGAGTAGTGCAAGATAGG
rs1859176	GCTTATAGTGATTCATGCCC	GGACAAGTTGTTTTTCACTG
rs1859177	CTACCAAAAGGGCACTTGAC	GATTAGTTATTGAGCAGAGGG
rs2074401	CCAGCATTTGTCAGATGAGG	GGTTTAGGTTTCAATTCTGG
rs4299948	GAGAGAGGTTGGAATGACAC	GAGGGAGACTCCATCTCAAA
rs4348435	CTAAGGCTACTACGAGCATG	AAGGGTTAACAGAGTGCCTG
rs4348436	TTTTGGTTGAATTCTAAGGC	AAGGGTTAACAGAGTGCCTG
rs4413718	TGTAGCTTTTTCTCTAGCCG	GAGGACTGTAAGCTTAGAATG
rs985199	TTCCATCTTTTTAGAACGCC	GAGAAAAAGCTACATGGCAC
rs7791413	CCACTCTTTCCTTTACTTGG	TAAGATACATCTTTGGGGCC
rs2522830	AATGCCAAAAGGATATTTGC	TGTATGTAAAAATGATGACC
rs2214414	TTTCAGGGATCTGCAAGGTC	AAAACTCCACTGTACACTCG
rs2189246	GACAGTCACCTTAACAATTAC	GAAACAAGAAGCTTAGAGAC
rs5885312	GAGTTGTGAAGTTCTGAGTG	TCAGCTTTCTTGAAGAGATTC
rs3064840	CTAGAGTTGTGAAGTTCTGAG	CAGCTTTCTTGAAGAGATTC
rs2051791	GTCATTGGCAATGAGGATGC	CAACTACCTAATTCAAATGTC
rs6467914	GAAAATTCATGTGTTTTTGGC	GTATACTGAACAAGACCATG
rs2214415	TTCCACTTTTCATCCACATG	TCTTCCCCCAGATCATGTTG
rs2189247	TCAAACAAAAATAGCTCAGG	GAAGCATTCCTAAAACCTTG
rs3064869	ACCAAACCAACTAGCATGGG	GCCTAAACAACTCTCCGTAG
rs2522831	GTACAGAGTGTTTTGTCATCC	TGCTCACGCATAAAACAGGG
rs2715147	GATCCATGTATATTTCCAGGC	CTAGTTTTTCTCTCTGCACTT
rs3064870	CTCTCACCTTTTCTTCCATC	GGGAAGTGTTTGATTACTGTG
rs2715148	TACCAGTTGGAATGTGGATC	CAAGAGAGAACTTTCACCATG
rs2522832	AATGCCATGCCCACAAAAGC	AGCACACAGCAAGAACATCC
rs1044639	CTCCTTTGTTTCCACCATCC	CGCAAACAAAAAGGACACAC
rs2715149	AAACTGAGCTACTGCCTCTG	GTTCAGTATATCTAGGTAAGG
rs2522833	TACCACCTTGGAGTGTTATC	TTCCTTGGTTTATATCCTTG
rs2247523	GGGACAAAATGGAAAAGAATG	GGTAGTCATATCCCTATTTC
rs2371214	TTGATCCTAGGCAGGAGTAC	GAAGGACTTCAGTAAGTCAC
rs2189248	TACACTTACTATGTACTTGT	AGATTAAAAATCACAAGATC
rs2715150	ACCATAGCAGCAAATAAGGG	ACACTGGAGGTGACAGTTTG
rs2715151	TAATTTTTGCCTACAGTTAC	GGCATTGTGGTGCTAATCTC
rs2371215	TAAGTTGAATGCACAGTGAC	TAGAACACCTACAAGCATTTC
rs2715152	CATCTTTTTCTCAGTACACTC	GCCCCATAAACAATAATTTGG
rs2715153	AATGCAGATGTCCCAAGTTC	ATAAATTTTTGGTTTATGTC
rs972346	GGTGAGAAAACTTGAAGCTC	CCTATGTTTGGATCCTGGTC
rs2715154	GCGTAATTGTTCCACAACAC	CATCGTGAACAAGTTAGGCC
rs2522834	TGGAGAATCAAACTCATTAC	TGGCCAGATACATTTAGAAA
rs2023847	CAGCCTGACTTTATGCTCAC	CAAAATCTGTGGAGTTGAAGG
rs2715155	GAAGGCTTCTTTGGTGTATC	GTTTAGTAAAGGAAAACCAG
rs2715156	ATTGATCAGAGGGTGGGAAG	ATAAGAGTCCTGTTAGCTAG
rs10715043	AGGGACCAAGTTCAAACACC	CTGCACTCCAGCCTCAAAAA
AD	TATACACCTGCACTGGACAT	GATTTAAGTTCTCGAGTCTTC
rs2301722	AGGCAGCTAATAAGCTACCC	TTCCAAGGCCTTTGCTTGTC
rs2257207	GTACCGAAAGGTATCTATAGG	GCTGTCAGCACTGAAATGTA
rs2715157	GCACAATTGTGGCTGAATAC	GAAGAAAAAAATGCTTAACTC
rs2715158	AAGCAGAAGTGGAGTGTGAG	AGGTCATCAGGGTAGTACTG
rs2715159	CCACAAAAGACCCTAATAGC	AGTAGCATAATTCCTCTGGC
rs2522835	CCATTCCATATGTCTGTCTG	AGCCAGAGGAATTATGCTAC
rs2522836	ACAGAGTCTCACTCTGTCCC	TCACTTGAATATGGGAGGCG
AE	GAGACATTTTTCAAGTTCCTC	CTCTTCTGAGTACAAAACTG
rs2522837	AAACATAGGAAAAAGTGATG	CATGATGAGATAGATTTAAC
rs2522838	CCTGTGAAAGTAATGCTTGG	CTAAAAAGAATCAAGTACGC
AF	TGCAGAGGCAGATGTAATTG	GCTACAATGCCCTAGATTTTG
rs2522839	TACACCACTGCACTCCAGTC	CCACAATTATGTTGTTGAACC
rs2522840	TGTGCTCCTGCAGAAATGTG	GGAGGAAGAGTACATTAATA
rs2522841	CTGGAAAATATTACCCATGTG	TCTGTGTACTTTCATACCTG
rs10555175	ATAGTGCAAGACCCTGTCTC	TGAAAGTACACAGATGAGAC
rs10592258	ATAGTGCAAGACCCTGTCTC	TGAAAGTACACAGATGAGAC
rs2522842	AATCCTATCATCGATGCTAC	CCATGCCTGGCCTTTAATAG
rs6956848	CTTTTTCAGTGTTTAGTAGCC	GAGTTTTGCTGAATATGTAGC
rs2522843	TCGATGATAGGATTTGTTGC	TACTAAGTTCTTGAATTACC
rs2522844	CCAATTGTTTTCTAGTAGACT	TGGTAGGCACTACACAATTC
rs2522845	ATGTACACCAGTGGTTTGCC	AAACCAGTAGTGGATCAGCC
rs2715161	TAGCTCCTACATATGGAGTG	AACAGGGCTGGAATTGGAGG
rs6972720	TCTCCAGATCCTATTCTATG	CACAACTCATGTACATCAGG
rs4377905	AATGCAAACTGTCTAAGCAC	TATGGCTGTATCAATATCAC
rs4579453	TCTCAGCTCACTGCACTGTC	GACTGTAATCCCAGCTACTC
rs4260846	AGAGCAAGATGCCGTCTCAG	GGAAATATACCATATAAATG
rs1986481	AAGCATGACATTATGTTTCC	AGTACCCAGGTGTTCTTAGC
rs4628206	GCGTTAGGTACACATGACAC	CTTCACAGAAGAGAGTTTCC
rs2888017	CACTAGTCATCAGGGAAATC	CATCTCCTTGCCAGCATCTC

	TABLE 28
	Term
	dbSNP rs #	Extend Primer	Mix
	rs2158220	CTGAGGCCTGCCCCTGA	ACT
	rs1024465	TTAAGGCATCTCTGTATATACTAA	ACG
	rs4732483	CAGATGCTGGAGAGGAT	ACT
	rs4732485	GACAGCTTCAGATATTTCA	ACG
	rs1859176	CATGCCCAATTCATATAGATA	ACG
	rs1859177	TCTGTCTTGTTCCCATC	ACG
	rs2074401	CAGATGAGGTTTCTGAAG	ACT
	rs4299948	AAGGACTATAGGGCTACTA	ACT
	rs4348435	CATGCCTACCTGTTAATATG	ACG
	rs4348436	GAATTCTAAGGCTACTACGA	ACT
	rs4413718	AAGAAGTGGTCTACTGTC	ACT
	rs985199	GAACGCCTTATCTAAGCA	ACG
	rs7791413	CTTGGTACTTAGTAATACACTTA	ACT
	rs2522830	AGGATATTTGCAAACGTG	ACG
	rs2214414	TGCAAGGTCAAAATATTCTT	ACT
	rs2189246	ATCAAGTTTTCAGCTTTCTTGAA	ACT
	rs5885312	GTGAAGTTCTGAGTGAAACAAG	CGT
	rs3064840	GTGAAGTTCTGAGTGAAACAAG	CGT
	rs2051791	GATGCTTTAAAACAAAAACTACA	ACG
	rs6467914	ATGTGTTTTTGGCTTTTTAGTGA	ACG
	rs2214415	CCATAATATTTCACCCATTCT	ACG
	rs2189247	AAAATAGCTCAGGTTTTTCA	CGT
	rs3064869	CATGGGGAAAACAACAACAAC	CGT
	rs2522831	ACATTAAGTGGATGAGGT	ACT
	rs2715147	TATTTCCAGGCACTTCA	ACT
	rs3064870	TTCTTCATGTTATTCACGTTCTT	CGT
	rs2715148	GAATGTGGATCAGTGTTT	ACT
	rs2522832	AGACAATCTCTAAAAATTAA	ACT
	rs1044639	CATCCATCCAACCTGGCTC	CGT
	rs2715149	CCTCTGTGGGATAAAACA	CGT
	rs2522833	GAGTGTTATCGAGGTGAG	CGT
	rs2247523	TGAGTAAGTTGCAATTACAAA	ACT
	rs2371214	CAGGAGTACTCTAGATTAGT	ACT
	rs2189248	CAAATAATCATGAAATTGGTAGC	ACT
	rs2715150	AAATAAGGGAAAGGAAGTC	ACT
	rs2715151	TTGCCTACAGTTACTTATCT	ACT
	rs2371215	GTAGTTTTCTTTGCCCT	CGT
	rs2715152	CAATGTTTTAGTTTTGCTTTTC	ACG
	rs2715153	TTTGGTTCATCAATTGTAAAATA	ACT
	rs972346	GAAGCTCAGAAAAATTAAGG	ACG
	rs2715154	TTCCACAACACTCACTT	CGT
	rs2522834	CATTTTAACTTTTGTCCAATCA	ACT
	rs2023847	TAAGAATCCCCCTGTTT	CGT
	rs2715155	GGTGTATCTACTTTCATAAAATT	ACT
	rs2715156	AGGGTGGGAAGAAAAAA	ACT
	rs10715043	TCAAACACCTATTATCTTTTTTTTT	ACT
	AD	GCACTGGACATCCAGAAGAC	ACT
	rs2301722	GGTCTTTCTTTTAATCACAC	ACT
	rs2257207	CGAAAGGTATCTATAGGTTTAATA	CGT
	rs2715157	AACAAATATTTGAGAAAACTGC	ACT
	rs2715158	TGTGCAGAAGGTTGACA	ACT
	rs2715159	CCTAATAGCCAAAGCAATTTT	ACT
	rs2522835	CATATGTCTGTCTGCTTTTA	CGT
	rs2522836	CAGTGGTGTGATCTCTG	CGT
	AE	TTCAAGTTCCTCATAATAACTAC	ACT
	rs2522837	CAATGGATTTAACAAATTTGTAG	ACT
	rs2522838	ATGCTTGGAGCCATTTC	CGT
	AF	AATTGTAGATGAAGATGTAGACA	CGT
	rs2522839	GACAGAGTGGGACCTGT	ACG
	rs2522840	TGCAGAAATGTGACAATG	CGT
	rs252284	TTATTACCCATGTGAATTATGATAT	ACT
	rs10555175	GACCCTGTCTCAAAAAATAAATAA	CGT
	rs10592258	GACCCTGTCTCAAAAAATAAATAA	CGT
	rs2522842	GATGCTACATATTCAGCAAAA	CGT
	rs6956848	CCTATTAAGCAAAAGACTTTGC	CGT
	rs2522843	CAAAGTCTTTTGCTTAATAGG	CGT
	rs2522844	ACACCATAAAATGTTAGACATAA	ACT
	rs2522845	CTGCTGGCTTCCTACTT	ACT
	rs2715161	CTACATATGGAGTGAGAACA	ACG
	rs6972720	ATGGGTACCCTTAGACACAC	ACG
	rs4377905	AACTGTCTAAGCACTCTAAA	ACT
	rs4579453	TCTGCCTCCCTGGTTCA	ACT
	rs4260846	ACAAACAAACAAACAAAAAAC	CGT
	rs1986481	TTTTGCCAACTATTATCCC	CGT
	rs4628206	CATGACACAGACCACAT	CGT
	rs2888017	GAAATCCAAATTAAAACCACA	ACT

Genetic Analysis

Allelotyping results are shown for female (F) and male (M) cases and controls in Table 29 and Table 30, respectively. Allele frequency is noted in the fourth and fifth columns for melanoma pools and control pools, respectively.

TABLE 29
Females
								Melanoma
	Chromo-	Chromosome		Female	Female	F	Odds	Associated
dbSNP rs#	some	Position	Alleles	Case AF	Control AF	p-Value	Ratio	Allele
rs2158220	7	82023020	T/C	T =	T =
				C =	C =
rs1024465	7	82024165	G/A	G = 0.845	G = 0.845	0.987	0.997	A
				A = 0.154	A = 0.154
rs4732483	7	82028598	T/C	T = 0.112	T = 0.108	0.866	0.960	T
				C = 0.888	C = 0.892
rs4732485	7	82031677	C/T	C = 0.050	C = 0.047	0.868	0.946	C
				T = 0.949	T = 0.952
rs1859176	7	82040109	C/T	C = 0.647	C = 0.761	˜0.001	1.738	T
				T = 0.352	T = 0.238
rs1859177	7	82040246	C/T	C = 0.979	C = 0.981	0.655	1.291	T
				T = 0.021	T = 0.019
rs2074401	7	82041637	A/G	A = 0.620	A = 0.557	0.096	0.771	A
				G = 0.379	G = 0.442
rs4299948	7	82041959	T/G	T =	T =
				G =	G =
rs4348435	7	82043702	G/A	G = 0.735	G = 0.742	0.828	1.033	A
				A = 0.264	A = 0.257
rs4348436	7	82043723	G/C	G = 0.813	G = 0.821	0.782	1.050	C
				C = 0.186	C = 0.178
rs4413718	7	82043866	G/C	G = 0.960	G = 0.968	0.596	1.267	C
				C = 0.039	C = 0.031
rs985199	7	82043947	G/A	G = 0.244	G = 0.244	0.980	1.004	G
				A = 0.755	A = 0.755
rs7791413	7	82051808	T/C	T = 0.697	T = 0.650	0.195	0.809	T
				C = 0.302	C = 0.349
rs2522830	7	82055154	G/A	G = 0.630	G = 0.569	0.082	0.775	G
				A = 0.369	A = 0.430
rs2214414	7	82056163	T/C	T = 0.582	T = 0.651	0.049	1.340	C
				C = 0.417	C = 0.348
rs2189246	7	82056423	A/G	A = 0.160	A = 0.126	0.197	0.756	A
				G = 0.839	G = 0.873
rs5885312	7	82056469	CTTAAGAA/—	CTTAAGAA = 0.070	CTTAAGAA = 0.101	0.137	1.504	—
				— = 0.929	— = 0.898
rs3064840	7	82056472	AAGAACTT/—	AAGAACTT = 0.042	AAGAACTT = 0.050	0.624	1.196	—
				— = 0.957	— = 0.949
rs2051791	7	82056789	C/T	C = 0.449	C = 0.541	0.007	1.445	T
				T = 0.550	T = 0.458
rs6467914	7	82057396	C/T	C = 0.121	C = 0.204	0.001	1.852	T
				T = 0.878	T = 0.795
rs2214415	7	82057533	G/A	G = 0.576	G = 0.611	0.387	1.156	A
				A = 0.423	A = 0.388
rs2189247	7	82059296	C/A	C = 0.689	C = 0.607	0.027	0.697	C
				A = 0.310	A = 0.392
rs3064869	7	82059469	—/ACA	— = 0.555	— = 0.635	0.015	1.393	A
				ACA = 0.444	ACA = 0.364
rs2522831	7	82060151	T/C	T =	T =
				C =	C =
rs2715147	7	82060456	T/C	T = 0.597	T = 0.656	0.090	1.285	C
				C = 0.402	C = 0.343
rs3064870	7	82060855	—/TAAG	— = 0.279	— = 0.252	0.398	0.872	—
				TAAG = 0.720	TAAG = 0.747
rs2715148	7	82062086	A/C	A = 0.558	A = 0.463	0.004	0.681	A
				C = 0.441	C = 0.536
rs2522832	7	82062415	A/G	A =	A =
				G =	G =
rs1044639	7	82063609	G/T	G = 0.413	G = 0.485	0.026	1.339	T
				T = 0.586	T = 0.514
rs2715149	7	82064863	A/T	A = 0.927	A = 0.954	0.256	1.648	T
				T = 0.072	T = 0.045
rs2522833	7	82065759	C/A	C = 0.384	C = 0.523	˜0.001	1.762	A
				A = 0.615	A = 0.476
rs2247523	7	82066455	C/G	C = 0.633	C = 0.575	0.079	0.783	C
				G = 0.366	G = 0.424
rs2371214	7	82066723	T/C	T = 0.637	T = 0.569	0.042	0.752	T
				C = 0.362	C = 0.430
rs2189248	7	82067356	T/C	T = 0.276	T = 0.274	0.945	0.990	T
				C = 0.723	C = 0.725
rs2715150	7	82067946	A/G	A = 0.787	A = 0.749	0.205	0.811	A
				G = 0.212	G = 0.250
rs2715151	7	82068714	C/G	C = 0.632	C = 0.546	0.010	0.699	C
				G = 0.367	G = 0.453
rs2371215	7	82069545	T/A	T = 0.626	T = 0.536	0.008	0.688	T
				A = 0.373	A = 0.463
rs2715152	7	82069717	G/A	G = 0.680	G = 0.649	0.322	0.868	G
				A = 0.319	A = 0.350
rs2715153	7	82069909	T/C	T = 0.549	T = 0.604	0.168	1.254	C
				C = 0.450	C = 0.395
rs972346	7	82072586	C/T	C = 0.949	C = 0.957	0.631	1.182	T
				T = 0.050	T = 0.042
rs2715154	7	82072917	G/T	G = 0.652	G = 0.558	0.006	0.673	G
				T = 0.347	T = 0.441
rs2522834	7	82072997	T/C	T = 0.424	T = 0.424	0.995	0.999	C
				C = 0.575	C = 0.575
rs2023847	7	82073344	G/T	G = 0.464	G = 0.357	0.001	0.641	G
				T = 0.535	T = 0.642
rs2715155	7	82074105	A/G	A = 0.674	A = 0.592	0.026	0.701	A
				G = 0.325	G = 0.407
rs2715156	7	82074885	A/G	A = 0.496	A = 0.556	0.080	1.276	G
				G = 0.503	G = 0.443
rs10715043	7	82076323	—/G	— = 0.501	— = 0.558	0.082	1.258	G
				G = 0.498	G = 0.441
AD	7	82076643	C/G	C = 0.973	C = 0.965	0.582	0.773	C
				G = 0.026	G = 0.034
rs2301722	7	82077285	A/C	A = 0.966	A = 0.961	0.729	0.864	A
				C = 0.033	C = 0.038
rs2257207	7	82080235	A/T	A = 0.612	A = 0.557	0.123	0.798	A
				T = 0.387	T = 0.442
rs2715157	7	82080425	A/G	A = 0.614	A = 0.529	0.009	0.707	A
				G = 0.385	G = 0.470
rs2715158	7	82081657	G/C	G = 0.742	G = 0.680	0.048	0.740	G
				C = 0.257	C = 0.319
rs2715159	7	82083459	A/G	A = 0.726	A = 0.619	˜0.001	0.613	A
				G = 0.273	G = 0.380
rs2522835	7	82083547	A/T	A = 0.542	A = 0.685	˜0.001	1.840	T
				T = 0.457	T = 0.314
rs2522836	7	82085104	C/A	C = 0.532	C = 0.519	0.714	0.948	C
				A = 0.467	A = 0.480
AE	7	82086424	T/G	T = 0.957	T = 0.991	0.009	5.183	G
				G = 0.043	G = 0.009
rs2522837	7	82087433	A/G	A = 0.649	A = 0.564	0.019	0.700	A
				G = 0.350	G = 0.435
rs2522838	7	82087608	A/T	A = 0.458	A = 0.512	0.127	1.239	T
				T = 0.541	T = 0.487
AF	7	82087839	AT/—	AT = 0.668	AT = 0.592	0.028	0.721	A
				— = 0.331	— = 0.407
rs2522839	7	82089699	G/A	G = 0.650	G = 0.676	0.534	1.126	A
				A = 0.349	A = 0.323
rs2522840	7	82090466	G/T	G = 0.511	G = 0.555	0.288	1.193	T
				T = 0.488	T = 0.444
rs2522841	7	82091245	T/G	T = 0.422	T = 0.488	0.067	1.305	G
				G = 0.577	G = 0.511
rs10555175	7	82091377	—/TTAT	— = 0.623	— = 0.707	0.018	1.460	T
				TTAT = 0.376	TTAT = 0.292
rs10592258	7	82091381	—/TATTATT	— = 0.618	— = 0.682	0.073	1.326	T
				TATTATT = 0.381	TATTATT = 0.317
rs2522842	7	82091713	G/T	G = 0.648	G = 0.584	0.062	0.764	G
				T = 0.351	T = 0.415
rs6956848	7	82091750	G/T	G =	G =
				T =	T =
rs2522843	7	82091773	C/A	C = 0.567	C = 0.569	0.956	1.007	A
				A = 0.432	A = 0.430
rs2522844	7	82092143	T/C	T = 0.459	T = 0.517	0.109	1.262	C
				C = 0.540	C = 0.482
rs2522845	7	82093960	T/G	T = 0.657	T = 0.592	0.045	0.757	T
				G = 0.342	G = 0.407
rs2715161	7	82094332	C/T	C = 0.616	C = 0.558	0.083	0.786	C
				T = 0.383	T = 0.441
rs6972720	7	82094726	C/T	C = 0.777	C = 0.779	0.940	1.012	T
				T = 0.222	T = 0.220
rs4377905	7	82106362	A/G	A = 0.955	A = 0.960	0.760	1.123	G
				G = 0.044	G = 0.039
rs4579453	7	82106772	T/C	T = 0.954	T = 0.911	0.016	0.490	T
				C = 0.045	C = 0.088
rs4260846	7	82106887	C/A	C = 0.729	C = 0.709	0.510	0.906	C
				A = 0.270	A = 0.290
rs1986481	7	82108734	A/T	A = 0.437	A = 0.375	0.058	0.772	A
				T = 0.562	T = 0.624
rs4628206	7	82109394	A/T	A = 0.854	A = 0.846	0.757	0.941	A
				T = 0.145	T = 0.153
rs2888017	7	82112254	A/G	A = 0.868	A = 0.865	0.907	0.976	A
				G = 0.131	G = 0.134

TABLE 30
Males
								Melanoma
	Chromo-	Chromosome		Male	Male	M	Odds	Associated
dbSNP rs#	some	Position	Alleles	Case AF	Control AF	p-Value	Ratio	Allele
rs2158220	7	82023020	T/C	T = 0.740	T = 0.682	0.076	0.753	T
				C = 0.259	C = 0.317
rs1024465	7	82024165	G/A	G = 0.864	G = 0.878	0.622	1.127	A
				A = 0.135	A = 0.121
rs4732483	7	82028598	T/C	T = 0.115	T = 0.111	0.903	0.970	T
				C = 0.885	C = 0.889
rs4732485	7	82031677	C/T	C = 0.040	C = 0.030	0.572	0.741	C
				T = 0.959	T = 0.969
rs1859176	7	82040109	C/T	C =	C =
				T =	T =
rs1859177	7	82040246	C/T	C = 0.989	C = 0.985	0.743	0.716	C
				T = 0.011	T = 0.015
rs2074401	7	82041637	A/G	A = 0.633	A = 0.574	0.095	0.781	A
				G = 0.366	G = 0.425
rs4299948	7	82041959	T/G	T = 0.089	T = 0.337	1.332	5.184	G
				G = 0.910	G = 0.662
rs4348435	7	82043702	G/A	G = 0.760	G = 0.772	0.669	1.073	A
				A = 0.239	A = 0.227
rs4348436	7	82043723	G/C	G = 0.831	G = 0.864	0.205	1.293	C
				C = 0.168	C = 0.135
rs4413718	7	82043866	G/C	G = 0.959	G = 0.972	0.375	1.486	C
				C = 0.040	C = 0.027
rs985199	7	82043947	G/A	G = 0.224	G = 0.222	0.949	0.989	G
				A = 0.775	A = 0.777
rs7791413	7	82051808	T/C	T = 0.725	T = 0.698	0.396	0.877	T
				C = 0.274	C = 0.301
rs2522830	7	82055154	G/A	G = 0.659	G = 0.574	0.015	0.696	G
				A = 0.340	A = 0.425
rs2214414	7	82056163	T/C	T = 0.556	T = 0.632	0.054	1.369	C
				C = 0.443	C = 0.367
rs2189246	7	82056423	A/G	A =	A =
				G =	G =
rs5885312	7	82056469	CTTAAGAA/—	CTTAAGAA = 0.057	CTTAAGAA = 0.061	0.803	1.083	—
				— = 0.942	— = 0.938
rs3064840	7	82056472	AAGAACTT/—	AAGAACTT = 0.043	AAGAACTT = 0.039	0.859	0.919	A
				— = 0.956	— = 0.960
rs2051791	7	82056789	C/T	C = 0.469	C = 0.562	0.025	1.455	T
				T = 0.530	T = 0.437
rs6467914	7	82057396	C/T	C = 0.149	C = 0.164	0.569	1.121	T
				T = 0.850	T = 0.835
rs2214415	7	82057533	G/A	G = 0.623	G = 0.621	0.976	0.994	G
				A = 0.376	A = 0.378
rs2189247	7	82059296	C/A	C = 0.653	C = 0.626	0.408	0.886	C
				A = 0.346	A = 0.373
rs3064869	7	82059469	—/ACA	— = 0.553	— = 0.605	0.127	1.238	A
				ACA = 0.446	ACA = 0.394
rs2522831	7	82060151	T/C	T = 0.714	T = 0.699	0.709	0.932	T
				C = 0.285	C = 0.300
rs2715147	7	82060456	T/C	T = 0.572	T = 0.611	0.338	1.176	C
				C = 0.427	C = 0.388
rs3064870	7	82060855	—/TAAG	— = 0.231	— = 0.207	0.420	0.869	—
				TAAG = 0.768	TAAG = 0.792
rs2715148	7	82062086	A/C	A = 0.557	A = 0.502	0.141	0.802	A
				C = 0.442	C = 0.497
rs2522832	7	82062415	A/G	A = 0.662	A = 0.628	0.335	0.861	A
				G = 0.337	G = 0.371
rs1044639	7	82063609	G/T	G = 0.429	G = 0.488	0.090	1.273	T
				T = 0.570	T = 0.511
rs2715149	7	82064863	A/T	A = 0.907	A = 0.940	0.097	1.620	T
				T = 0.092	T = 0.059
rs2522833	7	82065759	C/A	C = 0.396	C = 0.503	0.003	1.543	A
				A = 0.603	A = 0.496
rs2247523	7	82066455	C/G	C = 0.646	C = 0.582	0.061	0.764	C
				G = 0.353	G = 0.417
rs2371214	7	82066723	T/C	T = 0.619	T = 0.592	0.471	0.893	T
				C = 0.380	C = 0.407
rs2189248	7	82067356	T/C	T = 0.246	T = 0.238	0.821	0.958	T
				C = 0.753	C = 0.761
rs2715150	7	82067946	A/G	A = 0.802	A = 0.778	0.441	0.868	A
				G = 0.197	G = 0.221
rs2715151	7	82068714	C/G	C = 0.631	C = 0.597	0.414	0.864	C
				G = 0.368	G = 0.402
rs2371215	7	82069545	T/A	T = 0.620	T = 0.544	0.025	0.731	T
				A = 0.379	A = 0.455
rs2715152	7	82069717	G/A	G = 0.718	G = 0.688	0.450	0.866	G
				A = 0.281	A = 0.311
rs2715153	7	82069909	T/C	T = 0.491	T = 0.595	0.016	1.523	C
				C = 0.508	C = 0.404
rs972346	7	82072586	C/T	C = 0.959	C = 0.970	0.485	1.362	T
				T = 0.040	T = 0.029
rs2715154	7	82072917	G/T	G = 0.632	G = 0.573	0.084	0.784	G
				T = 0.367	T = 0.426
rs2522834	7	82072997	T/C	T = 0.386	T = 0.428	0.222	1.189	C
				C = 0.613	C = 0.571
rs2023847	7	82073344	G/T	G = 0.467	G = 0.400	0.052	0.761	G
				T = 0.532	T = 0.599
rs2715155	7	82074105	A/G	A =	A =
				G =	G =
rs2715156	7	82074885	A/G	A = 0.411	A = 0.533	0.006	1.634	G
				G = 0.588	G = 0.466
rs10715043	7	82076323	—/G	— = 0.474	— = 0.533	0.092	1.263	G
				G = 0.525	G = 0.466
AD	7	82076643	C/G	C = 0.967	C = 0.977	0.506	1.410	G
				G = 0.032	G = 0.022
rs2301722	7	82077285	A/C	A = 0.965	A = 0.976	0.418	1.487	C
				C = 0.034	C = 0.023
rs2257207	7	82080235	A/T	A = 0.622	A = 0.582	0.234	0.843	A
				T = 0.377	T = 0.417
rs2715157	7	82080425	A/G	A =	A =
				G =	G =
rs2715158	7	82081657	G/C	G = 0.748	G = 0.682	0.091	0.724	G
				C = 0.251	C = 0.317
rs2715159	7	82083459	A/G	A = 0.733	A = 0.634	0.002	0.632	A
				G = 0.266	G = 0.365
rs2522835	7	82083547	A/T	A = 0.534	A = 0.651	˜0.001	1.630	T
				T = 0.465	T = 0.348
rs2522836	7	82085104	C/A	C = 0.570	C = 0.544	0.506	0.899	C
				A = 0.429	A = 0.455
AE	7	82086424	T/G	T = 0.940	T = 0.967	0.217	1.886	G
				G = 0.059	G = 0.032
rs2522837	7	82087433	A/G	A = 0.639	A = 0.606	0.341	0.869	A
				G = 0.360	G = 0.393
rs2522838	7	82087608	A/T	A = 0.451	A = 0.517	0.078	1.301	T
				T = 0.548	T = 0.482
AF	7	82087839	AT/—	AT = 0.676	AT = 0.592	0.028	0.721	A
				— = 0.323	— = 0.407
rs2522839	7	82089699	G/A	G =	G =
				A =	A =
rs2522840	7	82090466	G/T	G = 0.488	G = 0.550	0.101	1.284	T
				T = 0.511	T = 0.449
rs2522841	7	82091245	T/G	T = 0.411	T = 0.462	0.181	1.230	G
				G = 0.588	G = 0.537
rs10555175	7	82091377	—/TTAT	— = 0.620	— = 0.679	0.089	1.294	T
				TTAT = 0.379	TTAT = 0.320
rs10592258	7	82091381	—/TATTATT	— = 0.613	— = 0.670	0.090	1.283	T
				TATTATT = 0.386	TATTATT = 0.329
rs2522842	7	82091713	G/T	G = 0.647	G = 0.603	0.190	0.829	G
				T = 0.352	T = 0.396
rs6956848	7	82091750	G/T	G = 0.035	G = 0.150	˜0.001	4.818	T
				T = 0.964	T = 0.849
rs2522843	7	82091773	C/A	C = 0.576	C = 0.542	0.352	0.872	C
				A = 0.423	A = 0.457
rs2522844	7	82092143	T/C	T = 0.458	T = 0.501	0.219	1.187	C
				C = 0.541	C = 0.498
rs2522845	7	82093960	T/G	T = 0.677	T = 0.604	0.047	0.725	T
				G = 0.322	G = 0.395
rs2715161	7	82094332	C/T	C = 0.666	C = 0.591	0.051	0.725	C
				T = 0.333	T = 0.408
rs6972720	7	82094726	C/T	C = 0.796	C = 0.791	0.839	0.966	C
				T = 0.203	T = 0.208
rs4377905	7	82106362	A/G	A = 0.955	A = 0.975	0.180	1.828	G
				G = 0.044	G = 0.024
rs4579453	7	82106772	T/C	T = 0.959	T = 0.899	0.006	0.382	T
				C = 0.040	C = 0.100
rs4260846	7	82106887	C/A	C = 0.726	C = 0.707	0.590	0.912	C
				A = 0.273	A = 0.292
rs1986481	7	82108734	A/T	A = 0.485	A = 0.417	0.049	0.760	A
				T = 0.514	T = 0.582
rs4628206	7	82109394	A/T	A = 0.863	A = 0.858	0.826	0.954	A
				T = 0.136	T = 0.141
rs2888017	7	82112254	A/G	A = 0.902	A = 0.895	0.767	0.927	A
				G = 0.097	G = 0.104

Allelotyping results were considered significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The assay failed for those SNPs in which the allele frequency is blank. The combined allelotyping p-values for males and females were plotted in FIG. 4A and separately for females and males in FIGS. 4B and 4C, respectively. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele frequency in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIGS. 4A, 4B and 4C can be determined by consulting Table 29 or 30. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.

To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line (or generally top-most curve, e.g., see peak in left-most graph just to the left of position 92150000) provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10⁻⁸ were truncated at that value.

Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.

Example 9

FPGT/CARK Proximal SNPs

It has been discovered that a polymorphic variation (rs2034453) in an intron of a gene encoding cardiac troponin I interacting kinase (TNNI3K), also referred to as cardiac ankyrin repeat kinase (CARK), and near a gene encoding fucose-1-phosphate guanylyltransferase (FPGT) is associated with the occurrence of melanoma. See Table 3. Subsequently, ninety-two allelic variants located within or nearby the target genes were identified and subsequently allelotyped in melanoma case and control sample sets as described in Examples 1 and 2. Several SNPs, designated by SNP_ID “AG”, “AH”, and “AI” in column 1 of Table 20, are novel and were identified through SNP discovery methods using dye terminator sequencing. Methods of diedeoxynucleotide chain termination chemistry derived sequencing are described by Sanger et al. (Proc. Nat. Acad. Sci. USA 74, 5463-5467, 1997). Briefly, terminators are labeled with fluorescent dyes for automated detection. Fluorescein is measured by an argon ion laser in the sequencing instrument, which transfers light energy to a rhodamine acceptor dye. Each acceptor dye emits light at a characteristic wavelength for detection, identifying the nucleotide that terminated extension of the DNA fragment. Novel SNPs are identified when sequence from multiple samples are compared on one or more strands. The forward and reverse primers used to identify AG are GGGTGGCTCACTCTCTAGGAA and CCTAGCAGCTGCCATAGCC, respectively. The forward and reverse primers used to identify AH are AACTTGTCCACAACCCTCAGTT and TGAAGAGTTTGAATGTGAAGCTG, respectively. The forward and reverse primers used to identify AI are TGGCTTAGGAGAAAATGATCTTG and TTTTCTGTAACATTATACCAAGGAAC, respectively. The polymorphic variants are set forth in Table 31. The chromosome position provided in column four of Table 31 is based on Genome “Build 34” of NCBI's GenBank and dbSNP build “119”.

TABLE 31
		Position			Allele
	Chromo-	in SEQ	Chromosome	Allele	Present in	IUPAC
dbSNP rs#	some	ID NO: 5	Position	Variants	SEQ ID NO: 5	Code
AG	1	206	74033656	G/T	T	K
rs1412825	1	299	74033749	G/C	C	S
rs4422957	1	634	74034084	C/T	T	Y
rs3835390	1	990	74034440	AAAAG/—	A	N
rs944795	1	1,433	74034883	C/G	G	S
rs792310	1	1,978	74035428	G/A	G	R
rs526736	1	2,227	74035677	A/T	A	W
rs9804006	1	2,992	74036442	T/C	T	Y
rs577367	1	4,171	74037621	C/T	A	R
rs575754	1	4,313	74037763	T/C	G	R
rs573721	1	4,586	74038036	G/T	C	M
rs487917	1	5,381	74038831	C/T	G	R
rs792307	1	5,485	74038935	G/A	C	Y
rs476350	1	5,792	74039242	T/C	C	Y
rs9425023	1	6,396	74039846	T/C	T	Y
rs9425024	1	6,458	74039908	G/T	T	K
rs571848	1	8,004	74041454	A/G	A	R
rs489941	1	8,808	74042258	A/C	C	M
rs491623	1	8,959	74042409	A/G	G	R
rs956	1	9,125	74042575	T/A	T	W
AH	1	9,261	74042711	G/A	G	R
rs520806	1	9,826	74043276	C/T	C	Y
rs522759	1	10,067	74043517	T/C	T	Y
rs545664	1	10,262	74043712	G/A	A	R
rs545721	1	10,284	74043734	C/T	T	Y
rs536355	1	10,661	74044111	G/A	A	R
rs553044	1	11,058	74044508	G/T	T	K
rs581353	1	11,871	74045321	A/G	A	R
rs496008	1	12,291	74045741	T/A	A	W
rs7366854	1	13,150	74046600	C/T	C	Y
rs560808	1	14,718	74048168	C/A	C	M
rs485929	1	14,770	74048220	A/G	A	R
rs477134	1	15,399	74048849	T/G	T	K
rs505634	1	16,136	74049586	G/A	A	R
rs542136	1	16,345	74049795	G/A	A	R
rs545680	1	16,725	74050175	T/C	T	Y
rs522042	1	17,567	74051017	G/A	G	R
rs575961	1	17,695	74051145	C/T	T	Y
rs792321	1	18,453	74051903	A/G	A	R
rs524306	1	18,738	74052188	T/A	A	W
rs495027	1	18,744	74052194	A/C	C	M
rs525358	1	19,789	74053239	A/G	A	R
rs471496	1	20,391	74053841	G/A	G	R
rs504866	1	21,725	74055175	C/T	T	Y
rs532396	1	23,377	74056827	T/C	C	Y
rs533371	1	23,497	74056947	G/A	A	R
rs567060	1	24,849	74058299	A/G	A	R
rs4650251	1	30,033	74063483	A/G	G	R
rs3753183	1	35,584	74069034	G/T	T	K
rs518769	1	36,397	74069847	A/G	G	R
rs474215	1	36,736	74070186	T/C	C	Y
AI	1	37,592	74071042	T/C	C	Y
rs500203	1	38,136	74071586	T/A	A	W
rs532221	1	38,435	74071885	T/A	T	W
rs539534	1	39,222	74072672	C/T	T	Y
rs531412	1	39,270	74072720	G/A	A	R
rs9970514	1	40,243	74073693	C/G	G	S
rs568049	1	40,988	74074438	C/T	T	Y
rs9727250	1	44,065	74077515	T/C	C	Y
rs792323	1	44,079	74077529	C/T	C	Y
rs3765651	1	45,847	74079297	A/C	C	M
rs3765654	1	46,196	74079646	C/G	C	S
rs481387	1	46,935	74080385	C/T	C	Y
rs483259	1	47,114	74080564	T/C	C	Y
rs2034453	1	48,666	74082116	A/G	A	R
rs7536997	1	49,437	74082887	G/A	G	R
rs792324	1	49,556	74083006	T/C	T	Y
rs6660350	1	50,036	74083486	C/T	C	Y
rs492302	1	50,624	74084074	G/C	T	S
rs10493539	1	52,062	74085512	A/G	A	R
rs496720	1	55,198	74088648	G/A	A	R
rs570631	1	56,340	74089790	T/A	T	W
rs4593767	1	59,578	74093028	G/A	G	R
rs576802	1	60,781	74094231	T/A	A	W
rs518574	1	67,523	74100973	A/G	A	R
rs524252	1	69,082	74102532	C/T	C	Y
rs792327	1	70,006	74103456	G/A	A	R
rs792328	1	70,437	74103887	C/A	A	M
rs2039407	1	70,855	74104305	A/T	A	W
rs503770	1	71,931	74105381	T/C	T	Y
rs503904	1	71,990	74105440	A/G	A	R
rs514012	1	73,566	74107016	A/G	A	R
rs1412827	1	74,082	74107532	A/G	A	R
rs473834	1	79,519	74112969	G/A	A	R
rs480267	1	80,209	74113659	A/G	G	R
rs572180	1	85,684	74119134	G/T	G	K
rs1333029	1	85,807	74119257	G/A	G	R
rs485414	1	85,927	74119377	A/G	A	R
rs1412823	1	86,251	74119701	A/T	T	W
rs2027013	1	87,438	74120888	T/G	A	M
rs548881	1	95,030	74128480	C/T	C	Y
rs792329	1	97,175	74130625	C/T	A	R

Assay for Verifying and Allelotyping SNPs

The methods used to verify and allelotype the ninety-two proximal SNPs of Table 31 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 32 and Table 33, respectively.

TABLE 32
dbSNP rs #	Forward PCR primer	Reverse PCR primer
AG	ATTTGTCTGACTGTGTTGGG	TTTGTCACCCAAACTGAACC
rs1412825	TTGGCTGGCGCCCGGAAAA	TCCTGAGACCGTTGCTAGAG
rs4422957	GTTTGCTGGACTGTCACTTC	ATTAGCTAGCTACTCCTGGG
rs3835390	TGAGGGAGTAACAGAACATG	AGGGATTAAGTGTCATAGCC
rs944795	GAAGGGATCTTTGGGTTGTG	CCAGCTTTGCAAATCAATTC
rs792310	ACTGACCATAAAGCGCGTAC	AAAGGAGTTACCCCTTGGAG
rs526736	CCTTGAAAAACTTCCAGAATG	ACTGATAAGGTCCAAAGGAG
rs9804006	CACTAGTTATCTTGGGCCAG	AAAGTGCTGGGATTACAGGC
rs577367	TTTTTAAGCATTGTGGCCTC	TACTAGACTTTTGCCAGTAC
rs575754	GAAAAGTAGGAAGGACATGG	CAAAGGTTTTCATGTAACCA
rs573721	CTGGTTTGAAGCCTAAAAATG	CCTGGTATCTAATTTAATTTT
rs487917	TCACCTAGTGATGTTGGAGC	TACCAGCATCACCACTTGAG
rs792307	GGGACAACCTATGTATATGC	AGAGCCAGACTCCATCTCAA
rs476350	ATACCAACACTTTGGGAGGC	GGTTTCACCGTGTTAGCCAG
rs9425023	TATATGCCACTTGTTACTGC	TGGCAACAAGAAAATTTCTC
rs9425024	CCCAGGGTTTTATAACCCAT	GATTTGCAGTAACAAGTGGC
rs571848	CAGGGAACAAATTTTTCTAG	CTCAAAAAGGCAAAGTGTAC
rs489941	TTGTTTCTCAGCATCACCAG	CTCCTATCAGTCCTTCTAAC
rs491623	AGAAGCAGGCAGGAAAATGG	CATAACTTGAGATTCTAGCC
rs956	AGTCTGTGCTACTTTATGTC	CTCCTTGGGAAAAACTTTGG
AH	TGATGGCACTTCAGATTTGG	CCAAAGTTTTTCCCAAGGAG
rs520806	GTCAGAAAGAGATTTCTCACA	TTCAGACAGGTCACTTCTGG
rs522759	CAAAGCAACCAGAATCCATG	GCTCAATACTGTATTTTAACC
rs545664	CCCAGAAAACAGAATGTGCC	GACCAAGTTCACATGTGAGC
rs545721	GACCAAGTTCACATGTGAGC	CCCAGAAAACAGAATGTGCC
rs536355	ATAGCAGGCTTTTACACACC	GACCTACATGGATAAGTTTG
rs553044	CAAGTCCAGACGGCATCATG	CTGCCTTCTGTCACATATAG
rs581353	ATCACCTACCTGCACATCAG	CAATCAGTTACTTGCATGCAC
rs496008	ACCAACACATCATAGCTAAG	GAGAAAACAGTGGATACTGG
rs7366854	GGATATTAGCCCTTCGTCAG	CTACCATCAGAGTGAACAGG
rs560808	CAATGCCTTATTGTGTGCAG	AGGCTTTCTGCAACTTTGCG
rs485929	ACGCAAAGTTGCAGAAAGCC	TTCAATGCCTCATACACCCC
rs477134	CTGAATCATTGGAGCTAGGG	CTGTGCTCTGATATGTATCC
rs505634	AGGAGTGAATGTGGATAGAG	TTCTCCTCATCTTCCTCACC
rs542136	CTCTGTTATTGGAAAAAATTC	AAGCCAGCAGGATTATGAAG
rs545680	AATGAAAGTACACTCTACAG	CCCCCACAAATTCTGTAACG
rs522042	GAAGGAGTCTTGCTCTGTTG	AGGAGAATGGCCTGAACCTG
rs575961	GCACAAAATATACCATCGTC	GCACTGGACACCTGTTATTC
rs792321	GTTTCCCATGGCCTAAGATG	CTTCTCTGGTCTCCTGATAG
rs524306	TTGGTTTGGGATAAAGGAGG	AAGCCTCCCAAAAATATGCC
rs495027	CCTAATAATCTAAAGCCTCCC	TTGGTTTGGGATAAAGGAGG
rs525358	ATCTCTTAGTTTGGTACGCG	CACACTACACTTTGACTGGG
rs471496	TCATTTCCAAGAAATATGTG	GTTTATTTACTTTGAACCTG
rs504866	TCTAAATTGTGTCCAGACTC	TAAAAATCTTAGACAGTGGG
rs532396	TTCTAACTGTGGTGTTTCTG	CAAGACTTGTAATCAAATCC
rs533371	GGAAATTGTACATGCAAAGG	TTACTGGTACGGGAAGAATG
rs567060	ATAAACCAAGAGGCATGGTG	AACAAGAGCGAAACCCTGTC
rs4650251	TAGAGCAATCAGAGAAGAGG	GTGGAGTCTTTAGGTTTTTCC
rs3753183	AGCTTTGGCTTTCAAAGGTG	TGTGGGAGAATTCAACTGAG
rs518769	GGAAGCCTTACCTCTGAAAC	CAAACAACTCTCTTTTTGAA
rs474215	CAGTTCTGACCATGTGACTC	ATGGAAGGTGCATGAAAGAG
AI	CCAGTACAAGTTTGGGTTGG	GTCACTGCACTTGAACTTGG
rs500203	TCGAATGGGTTCTTCATTAC	GCAAAATGTAGACACAGATC
rs532221	CTTTGTATAAGTGTCTTCAG	TATGTCTGAGGTTCTACGGG
rs539534	GCAATGACCAAATGACACATC	CATGGGTGATTTTATTTGCC
rs531412	CCTTGTTACATCCATTGACG	GCAATGACCAAATGACACATC
rs9970514	TCCTACCATACCCTGCTTAC	TCTTGCCTACACACCTTTAC
rs568049	GATAAGGAAGCTGAGGAGAG	CCATTAACATAAGAGGCCCC
rs9727250	AATGGCGTGAATCCAGGAGG	TTTCAGACGGAGTCTCGCTC
rs792323	TTTTTCAGACGGAGTCTCGC	AATGGCGTGAATCCAGGAGG
rs3765651	CCCAAAGGTTACTTTCTTTC	TGGATCACAAAACTGCACAC
rs3765654	GGCAAAAGAAGAGAAAATGG	CTTCTAGTCAAACGTTTCTG
rs481387	AACCTGAAGTGAGCCTTAAG	CCATTCAATAAGTCTGGCAC
rs483259	CAGAACTGCACATGAGATTC	TTTGAGTCTCTCCACTGTTG
rs2034453	GTGACTGGAAACTGAGAATG	TTGCTGGACAATAGAAAGAC
rs7536997	AGGAATGAACAACTCCGGAC	CGACCTTCGCAGTGAGTGTT
rs792324	TGCTTCTCACTCTTTGGGTC	TGTGATCTTGCTGGCTTCAG
rs6660350	CTAGTAGATCCCACGCAGGG	AGTCCCATCCACCACCCAA
rs492302	TCTTATTTCTAATATCTCGG	TTCCTCCATATGTGGAAAAC
rs10493539	GAAGCACTTAAAGATTCCCC	GGCATTTATCACTTTTCCAC
rs496720	TGTGTCTAGCTCAGGGATTG	TGGTCCGTTTTACAGAGAGC
rs570631	TTGCATTTTGTCCCATTTCC	AAGACTGAAGTGGCAACAGG
rs4593767	ATTGATATATGAAGAAACAG	GTCCAATCTGCTGTTTTCAAC
rs576802	TCTACTTTTGCATTGCTTCC	GGCAATGGATGACAATAGTA
rs518574	GAGCTCCAGAGGAAAAATTG	AGGTGGTGGTAAAAGAAGGG
rs524252	TGGGAGATCTATTCTACCTC	TGGAAGAATGAGGCTTAGAC
rs792327	TGGTCCGTTTTACAGAGAGC	TGTGTCTAGCTCAGGGATTG
rs792328	TCAGCAGGCCATAGCTGCCTC	ATGCAAGAGCCCATGGCAGG
rs2039407	AATGACTATGTGCACTGGAG	TAAGGTGGTTACAATTACTC
rs503770	AATGCATCTTTGGTCCTGAC	TTGAGATGCCATTGATAGGC
rs503904	GAAGTCAGGACCAAAGATGC	CTAAGCTGCTTTCCCATTCC
rs514012	TCTTGTTCAAGCGGTAGAGG	CTCAGATGGTGGAAAGTAGG
rs1412827	GCTTTGGATAGTCAATTCAG	CCTCTGTATATCTAGCTACC
rs473834	TCTTGTGGGTATAAGCTGTG	CTACCTTCACATCTGTAGTC
rs480267	CATCCAAATGTTTCAGTAGAG	TTGGAGAGGAAACTAAAGCG
rs572180	AGCTTTTCTTGCTTATGCTC	CAGGTCTTTGGCATAGACTC
rs1333029	GGGATTTCTCATATCAGGTTG	GCCCTGGAAAATGATGGAAG
rs485414	GCACTGAATTTGCTTCCAAC	GTGTATATACATTATCTACAT
rs1412823	GTATTCCTAATTAAGGGGAAG	AAACCTCTGAGCTCACTATG
rs2027013	CTTCCCGTTTTTCTACCTGC	GAGCCAATGAAAGAAGAAAGG
rs548881	GTAGTTCTATAAGGTTTTGCC	CACCCTGGGAAACTATAAAC
rs792329	CACCACGCCCAGCTAATTTT	GTCAGGAGATCAAGACCATC

	TABLE 33
	Term
	dbSNP rs #	Extend Primer	Mix
	AG	CTGTGTTGGGGCTGGGCC	CGT
	rs1412825	GCGCCCGGAAAACCATGAT	ACT
	rs4422957	CCGTTTACTTCTCATCTG	ACG
	rs3835390	TGGAGGAATTATGGATTAAAAATT	ACT
	rs944795	CCTAACACCAAGTGTCC	ACT
	rs792310	TTGGCTCCAGCAGGATC	ACG
	rs526736	TTCCAGAATGTTACTTAAAAGA	CGT
	rs9804006	GGGCCAGTTACTTAACTCTTG	ACT
	rs577367	GCATTGTGGCCTCTGGCTA	ACG
	rs575754	GGACATGGTCTCAGAAT	ACT
	rs573721	GAAGCCTAAAAATGTGTAAAA	CGT
	rs487917	CCATTGTAAAGTCCTAGCA	ACG
	rs792307	GTATATGCTGTCCATAATTGAG	ACG
	rs476350	GGCAGGCAGATCACGAG	ACT
	rs9425023	TCAGGAAAGAATAATGAAATCCA	ACT
	rs9425024	CCCATAAGTTACAAATCAAAATAT	CGT
	rs571848	AAAAGCAGTTTGATGTAGAG	ACT
	rs489941	TAAAGTCAGTTCATCTGGTAATT	ACT
	rs491623	ACAGGTGATAAACAGTTTC	ACT
	rs956	GTCAATATAAAAATTGGTAAAC	CGT
	AH	GAATGACAAAGACATAACATCCT	ACG
	rs520806	AAGAGATTTCTCACAAATTGA	ACG
	rs522759	CAGAATCCATGCATTGT	ACT
	rs545664	GCTATTAGCCAGGCAGCAA	ACG
	rs545721	GCTGCCTGGCTAATAGCTA	ACG
	rs536355	CTGAGTATATGATGTAAG	ACG
	rs553044	GTATGTAAACAGCAACTCTG	CGT
	rs581353	GTCTAAAGATGTTCATCCC	ACT
	rs496008	TGCACATGTAAATGATTTTTTT	CGT
	rs7366854	CTTCGTCAGATGAGTAGGTTG	ACG
	rs560808	GTGTGCAGTAATAACAATGAT	CGT
	rs485929	AGAAAGCCTGCAAAGGA	ACT
	rs477134	TGGAGCTAGGGAGGAAG	ACT
	rs505634	ATGTGGATAGAGAAATTCAAA	ACG
	rs542136	TTTTCTTCCTTGTAGCATC	ACG
	rs545680	CACTCTACAGTGTGGGA	ACT
	rs522042	TAGCTCACTCCAAGCTC	ACG
	rs575961	CATCGTCATAGTAGAGATTC	ACG
	rs792321	AAGATGAATGGACTCTCCTGT	ACT
	rs524306	GGACATATTTACTTCTAGCTGAT	CGT
	rs495027	CCTCCCAAAAATATGCCTTTG	ACT
	rs525358	CGAGAGTGCTCGGTGCATA	ACT
	rs471496	GAAATATGTGTTTTAACGAGAA	ACG
	rs504866	GTGTCCAGACTCTTGATT	ACG
	rs532396	CTGTGGTGTTTCTGATGCCT	ACT
	rs533371	TGCAAAGGTGTTAGAAGCACCTC	ACG
	rs567060	AGGCATGGTGCTTAGAT	ACT
	rs4650251	GAAGAGGGAAAAAAGGACTTC	ACT
	rs3753183	CGATGAGTTTGAAAATCCA	CGT
	rs518769	CTGAGCAAAAATATATGGTGA	ACT
	rs474215	GTGACTCTAATATCCAAGCTA	ACT
	AI	AAGTTTCTTCCTTTCTCCAGG	ACT
	rs500203	AAACATCTGCATTTTAAAC	CGT
	rs532221	TGTCTTCAGTATTCACCTTA	CGT
	rs539534	GACCAAATGACACATCTTTAAAA	ACG
	rs531412	AACTATATTATACATGGGTGATTT	ACG
	rs9970514	TCCTGATTTATTCATTGATTTTTG	ACT
	rs568049	GAGGAGAGGATTATCCAGTC	ACG
	rs9727250	TCGCGCCACTGCACTCCA	ACT
	rs792323	AGGCTGGAGTGCAGTGG	ACG
	rs3765651	TTCCTAGCCTTTACCTTT	ACT
	rs3765654	AAAAGAAGAGAAAATGGAATTTCT	ACT
	rs481387	AGGCGTATAGTAGGTGTTTAG	ACG
	rs483259	CTCTTATTTAAACTTGATCTCTC	ACT
	rs2034453	AAACTGAGAATGTTGATGGACA	ACT
	rs7536997	AACAACTCCAGATGCGCCG	ACG
	rs792324	GTCCGCACTGCCTTTAT	ACT
	rs6660350	CACGCAGGGGCCGCAGG	ACG
	rs492302	TCTCGGATCTTCCATCC	ACT
	rs10493539	TCATCAAGCAGTTGCTTCACA	ACT
	rs496720	GTAAATGCACCAATCAGCACC	ACG
	rs570631	TCCCATTTCCATTATTTTTTTT	CGT
	rs4593767	GAAGAAACAGAAAAATGTGC	ACG
	rs576802	TTGCATTGCTTCCAAAATGATC	CGT
	rs518574	AGAGGAAAAATTGCCTATG	ACT
	rs524252	TTCTCAAGGATATAGCTGGAG	ACG
	rs792327	ATGCACCAATCAGCACC	ACG
	rs792328	GGGAAGCTCAGGCATGG	CGT
	rs2039407	GTGCACTGGAGCAGTTCTG	CGT
	rs503770	CTGCTAAGTCTGAGTCCCAT	ACT
	rs503904	AAGATGCATTTATCAGATTGTATA	ACT
	rs514012	GTAGAGGATTGATTAGAACTGA	ACT
	rs1412827	TTCTAACAGTGTATTTAATCATCA	ACT
	rs473834	CAGAAGAGTCTCTGGGGAG	ACG
	rs480267	ATTTTGTTTACCAAGAAGCCTC	ACT
	rs572180	CTTATGCTCTTCTACCTCA	CGT
	rs1333029	GTTGATTTGGTTAGCAATAAT	ACG
	rs485414	AACATCCTAGGTCCTCT	ACT
	rs1412823	CCTAATTAAGGGGAAGAAGAAG	CGT
	rs2027013	AAGAAGAAAGGTTGAAGAC	ACT
	rs548881	GGTTTTGCCTAATATATTTTGATG	ACG
	rs792329	GACCATCCTGGCTAACA	ACG

Genetic Analysis

Allelotyping results are shown for female (F) and male (M) cases and controls in Table 34 and Table 35, respectively. Allele frequency is noted in the fourth and fifth columns for melanoma pools and control pools, respectively.

TABLE 34
Females
								Melanoma
	Chromo-	Chromosome		Female	Female	F	Odds	Associated
dbSNP rs#	some	Position	Alleles	Case AF	Control AF	p-Value	Ratio	Allele
AG	1	74033656	G/T	G = 0.167	G = 0.106	0.027	0.593	G
				T = 0.832	T = 0.893
rs1412825	1	74033749	G/C	G = 0.539	G = 0.499	0.269	0.853	G
				C = 0.460	C = 0.500
rs4422957	1	74034084	C/T	C = 0.484	C = 0.427	0.089	0.796	C
				T = 0.515	T = 0.572
rs3835390	1	74034440	AAAAG/—	AAAAG = 0.580	AAAAG = 0.623	0.199	1.199	—
				— = 0.419	— = 0.376
rs944795	1	74034883	C/G	C = 0.592	C = 0.534	0.088	0.791	C
				G = 0.407	G = 0.465
rs792310	1	74035428	G/A	G = 0.508	G = 0.566	0.083	1.265	A
				A = 0.491	A = 0.433
rs526736	1	74035677	A/T	A = 0.637	A = 0.653	0.698	1.070	T
				T = 0.362	T = 0.346
rs9804006	1	74036442	T/C	T = 0.748	T = 0.700	0.112	0.785	T
				C = 0.251	C = 0.299
rs577367	1	74037621	C/T	C = 0.540	C = 0.460	0.025	0.727	C
				T = 0.459	T = 0.539
rs575754	1	74037763	T/C	T = 0.923	T = 0.938	0.414	1.257	C
				C = 0.076	C = 0.061
rs573721	1	74038036	G/T	G = 0.145	G = 0.151	0.861	1.050	T
				T = 0.854	T = 0.848
rs487917	1	74038831	C/T	C = 0.567	C = 0.642	0.020	1.369	T
				T = 0.432	T = 0.357
rs792307	1	74038935	G/A	G = 0.530	G = 0.617	0.002	1.431	A
				G = 0.495	G = 0.597
rs792307	1	74038935	G/A	A = 0.469	A = 0.382	0.002	1.431	A
				A = 0.504	A = 0.402
rs476350	1	74039242	T/C	T = 0.036	T = 0.042	0.729	1.192	C
				C = 0.963	C = 0.957
rs9425023	1	74039846	T/C	T = 0.595	T = 0.626	0.340	1.142	C
				C = 0.404	C = 0.373
rs9425024	1	74039908	G/T	G = 0.955	G = 0.954	0.976	0.989	G
				T = 0.044	T = 0.045
rs571848	1	74041454	A/G	A = 0.555	A = 0.607	0.116	1.237	G
				G = 0.444	G = 0.392
rs489941	1	74042258	A/C	A = 0.564	A = 0.465	0.003	0.672	A
				C = 0.435	C = 0.534
rs491623	1	74042409	A/G	A = 0.621	A = 0.528	0.008	0.682	A
				G = 0.378	G = 0.471
rs956	1	74042575	T/A	T = 0.613	T = 0.642	0.400	1.129	A
				A = 0.386	A = 0.357
AH	1	74042711	G/A	G = 0.976	G = 0.967	0.501	0.707	G
				A = 0.023	A = 0.032
rs520806	1	74043276	C/T	C = 0.586	C = 0.643	0.079	1.276	T
				T = 0.413	T = 0.356
rs522759	1	74043517	T/C	T = 0.691	T = 0.742	0.088	1.287	C
				C = 0.308	C = 0.257
rs545664	1	74043712	G/A	G = 0.562	G = 0.503	0.074	0.789	G
				A = 0.437	A = 0.496
rs545721	1	74043734	C/T	C = 0.510	C = 0.458	0.172	0.813	C
				T = 0.489	T = 0.541
rs536355	1	74044111	G/A	G = 0.534	G = 0.465	0.049	0.758	G
				A = 0.465	A = 0.534
rs553044	1	74044508	G/T	G = 0.503	G = 0.487	0.658	0.938	G
				T = 0.496	T = 0.512
rs581353	1	74045321	A/G	A = 0.604	A = 0.643	0.281	1.183	G
				G = 0.395	G = 0.356
rs496008	1	74045741	T/A	T = 0.864	T = 0.811	0.040	0.674	T
				A = 0.135	A = 0.188
rs7366854	1	74046600	C/T	C = 0.840	C = 0.851	0.677	1.089	T
				T = 0.159	T = 0.148
rs560808	1	74048168	C/A	C = 0.566	C = 0.640	0.033	1.360	A
				A = 0.433	A = 0.359
rs485929	1	74048220	A/G	A = 0.716	A = 0.718	0.943	1.011	G
				G = 0.283	G = 0.281
rs477134	1	74048849	T/G	T = 0.560	T = 0.624	0.056	1.306	G
				G = 0.439	G = 0.375
rs505634	1	74049586	G/A	G = 0.923	G = 0.945	0.251	1.447	A
				A = 0.076	A = 0.054
rs542136	1	74049795	G/A	G = 0.625	G = 0.525	0.007	0.661	G
				A = 0.374	A = 0.474
rs545680	1	74050175	T/C	T = 0.685	T = 0.719	0.276	1.175	C
				C = 0.314	C = 0.280
rs522042	1	74051017	G/A	G = 0.699	G =
				A = 0.301	A =
rs575961	1	74051145	C/T	C = 0.979	C = 0.948	0.116	0.390	C
				T = 0.020	T = 0.051
rs792321	1	74051903	A/G	A = 0.644	A = 0.675	0.384	1.148	G
				G = 0.355	G = 0.324
rs524306	1	74052188	T/A	T = 0.559	T = 0.468	0.005	0.693	T
				A = 0.440	A = 0.531
rs495027	1	74052194	A/C	A = 0.585	A = 0.499	0.011	0.707	A
				C = 0.414	C = 0.500
rs525358	1	74053239	A/G	A = 0.150	A = 0.141	0.731	0.930	A
				G = 0.849	G = 0.858
rs471496	1	74053841	G/A	G = 0.115	G = 0.123	0.743	1.078	A
				A = 0.884	A = 0.876
rs504866	1	74055175	C/T	C = 0.577	C = 0.465	0.002	0.639	C
				T = 0.422	T = 0.534
rs532396	1	74056827	T/C	T = 0.951	T = 0.955	0.790	1.102	C
				C = 0.048	C = 0.044
rs533371	1	74056947	G/A	G = 0.528	G = 0.484	0.184	0.840	G
				A = 0.471	A = 0.515
rs567060	1	74058299	A/G	A = 0.670	A = 0.707	0.248	1.189	G
				G = 0.329	G = 0.292
rs4650251	1	74063483	A/G	A = 0.571	A = 0.473	0.003	0.675	A
				G = 0.428	G = 0.526
rs3753183	1	74069034	G/T	G = 0.090	G = 0.053	0.046	0.571	G
				T = 0.909	T = 0.946
rs518769	1	74069847	A/G	A = 0.875	A = 0.875	0.996	1.001	A
				G = 0.124	G = 0.124
rs474215	1	74070186	T/C	T = 0.556	T = 0.452	0.002	0.658	T
				C = 0.443	C = 0.547
AI	1	74071042	T/C	T = 0.031	T = 0.041	0.551	1.349	C
				C = 0.968	C = 0.958
rs500203	1	74071586	T/A	T = 0.507	T = 0.425	0.016	0.718	T
				A = 0.492	A = 0.574
rs532221	1	74071885	T/A	T = 0.725	T = 0.783	0.043	1.368	A
				A = 0.274	A = 0.216
rs539534	1	74072672	C/T	C =	C =
				T =	T =
rs531412	1	74072720	G/A	G = 0.682	G = 0.753	0.034	1.423	A
				A = 0.317	A = 0.246
rs9970514	1	74073693	C/G	C = 0.421	C = 0.474	0.135	1.241	G
				G = 0.578	G = 0.525
rs568049	1	74074438	C/T	C = 0.783	C = 0.781	0.971	0.993	C
				T = 0.216	T = 0.218
rs9727250	1	74077515	T/C	T = 0.074	T = 0.057	0.336	0.758	T
				C = 0.925	C = 0.942
rs792323	1	74077529	C/T	C = 0.815	C = 0.817	0.933	1.014	T
				T = 0.462	T = 0.436
rs3765651	1	74079297	A/C	A = 0.666	A = 0.710	0.174	1.232	C
				C = 0.333	C = 0.289
rs3765654	1	74079646	C/G	C = 0.799	C = 0.686	˜0.001	0.551	C
				G = 0.200	G = 0.313
rs481387	1	74080385	C/T	C = 0.517	C = 0.447	0.048	0.755	C
				T = 0.482	T = 0.552
rs483259	1	74080564	T/C	T = 0.580	T = 0.665	0.015	1.438	C
				C = 0.419	C = 0.334
rs2034453	1	74082116	A/G	A = 0.208	A = 0.143	0.015	0.634	A
				G = 0.791	G = 0.856
rs7536997	1	74082887	G/A	G =	G =
				A =	A =
rs792324	1	74083006	T/C	T = 0.067	T = 0.053	0.496	0.779	T
				T = 0.038	T = 0.036
rs792324	1	74083006	T/C	C = 0.932	C = 0.946	0.496	0.779	T
				C = 0.961	C = 0.963
rs6660350	1	74083486	C/T	C = 0.191	C = 0.126	0.010	0.607	C
				T = 0.808	T = 0.873
rs492302	1	74084074	G/C	G =	G = 0.389
				C =	C = 0.611
rs10493539	1	74085512	A/G	A = 0.375	A = 0.330	0.175	0.821	A
				G = 0.624	G = 0.669
rs496720	1	74088648	G/A	G = 0.964	G = 0.977	0.394	1.598	A
				A = 0.035	A = 0.022
rs570631	1	74089790	T/A	T = 0.375	T = 0.392	0.688	1.074	A
				A = 0.624	A = 0.607
rs4593767	1	74093028	G/A	G = 0.231	G = 0.270	0.182	1.234	A
				A = 0.768	A = 0.729
rs576802	1	74094231	T/A	T = 0.860	T = 0.846	0.569	0.898	T
				A = 0.139	A = 0.153
rs518574	1	74100973	A/G	A = 0.972	A = 0.969	0.861	0.920	A
				G = 0.027	G = 0.030
rs524252	1	74102532	C/T	C = 0.828	C = 0.826	0.925	0.983	C
				T = 0.171	T = 0.173
rs792327	1	74103456	G/A	G = 0.957	G = 0.960	0.893	1.070	A
				A = 0.043	A = 0.040
rs792328	1	74103887	C/A	C =	C = 0.337
				A =	A = 0.663
rs2039407	1	74104305	A/T	A = 0.930	A = 0.962	0.049	1.924	T
				T = 0.069	T = 0.037
rs503770	1	74105381	T/C	T = 0.853	T = 0.816	0.137	0.764	T
				C = 0.146	C = 0.183
rs503904	1	74105440	A/G	A = 0.838	A = 0.809	0.269	0.820	A
				G = 0.161	G = 0.190
rs514012	1	74107016	A/G	A = 0.860	A = 0.811	0.062	0.698	A
				G = 0.139	G = 0.188
rs1412827	1	74107532	A/G	A = 0.385	A = 0.327	0.091	0.777	A
				G = 0.614	G = 0.672
rs473834	1	74112969	G/A	G = 0.142	G = 0.191	0.050	1.425	A
				A = 0.857	A = 0.808
rs480267	1	74113659	A/G	A = 0.317	A = 0.356	0.273	1.190	G
				G = 0.682	G = 0.643
rs572180	1	74119134	G/T	G = 0.868	G = 0.838	0.202	0.786	G
				T = 0.131	T = 0.161
rs1333029	1	74119257	G/A	G = 0.945	G = 0.971	0.088	1.948	A
				A = 0.054	A = 0.028
rs485414	1	74119377	A/G	A = 0.911	A = 0.906	0.824	0.947	A
				G = 0.088	G = 0.093
rs1412823	1	74119701	A/T	A = 0.774	A = 0.779	0.876	1.030	T
				T = 0.225	T = 0.220
rs2027013	1	74120888	T/G	T = 0.148	T = 0.075	0.005	0.470	T
				G = 0.852	G = 0.925
rs548881	1	74128480	C/T	C = 0.898	C = 0.862	0.176	0.709	C
				T = 0.101	T = 0.137
rs792329	1	74130625	C/T	C = 0.732	C = 0.744	0.688	1.070	T
				T = 0.268	T = 0.256

TABLE 35
Males
								Melanoma
	Chromo-	Chromosome		Male	Male	M	Odds	Associated
dbSNP rs#	some	Position	Alleles	Case AF	Control AF	p-Value	Ratio	Allele
AG	1	74033656	G/T	G = 0.136	G = 0.103	0.178	0.730	G
				T = 0.863	T = 0.896
rs1412825	1	74033749	G/C	G = 0.520	G = 0.518	0.947	0.990	G
				C = 0.479	C = 0.481
rs4422957	1	74034084	C/T	C = 0.462	C = 0.450	0.739	0.955	C
				T = 0.537	T = 0.549
rs3835390	1	74034440	AAAAG/—	AAAAG = 0.618	AAAAG = 0.599	0.588	0.924	A
				— = 0.381	— = 0.400
rs944795	1	74034883	C/G	C = 0.553	C = 0.540	0.707	0.948	C
				G = 0.446	G = 0.459
rs792310	1	74035428	G/A	G = 0.548	G = 0.564	0.630	1.069	A
				A = 0.451	A = 0.435
rs526736	1	74035677	A/T	A =	A =
				T =	T =
rs9804006	1	74036442	T/C	T = 0.724	T = 0.691	0.306	0.853	T
				C = 0.275	C = 0.308
rs577367	1	74037621	C/T	C =	C =
				T =	T =
rs575754	1	74037763	T/C	T = 0.929	T = 0.946	0.343	1.346	C
				C = 0.070	C = 0.053
rs573721	1	74038036	G/T	G = 0.094	G = 0.137	0.210	1.525	T
				T = 0.905	T = 0.862
rs487917	1	74038831	C/T	C = 0.629	C = 0.684	0.159	1.282	T
				T = 0.370	T = 0.315
rs792307	1	74038935	G/A	G = 0.591	G = 0.654	0.286	1.306	A
				G = 0.543	G = 0.583
rs792307	1	74038935	G/A	A = 0.408	A = 0.345	0.286	1.306	A
				A = 0.456	A = 0.416
rs476350	1	74039242	T/C	T = 0.052	T = 0.047	0.767	0.886	T
				C = 0.947	C = 0.952
rs9425023	1	74039846	T/C	T = 0.614	T = 0.594	0.577	0.919	T
				C = 0.385	C = 0.405
rs9425024	1	74039908	G/T	G = 0.953	G = 0.981	0.138	2.541	T
				T = 0.047	T = 0.019
rs571848	1	74041454	A/G	A = 0.600	A = 0.602	0.944	1.010	G
				G = 0.399	G = 0.397
rs489941	1	74042258	A/C	A = 0.500	A = 0.481	0.601	0.928	A
				C = 0.499	C = 0.518
rs491623	1	74042409	A/G	A = 0.577	A = 0.565	0.771	0.954	A
				G = 0.422	G = 0.434
rs956	1	74042575	T/A	T = 0.624	T = 0.627	0.939	1.011	A
				A = 0.375	A = 0.372
AH	1	74042711	G/A	G = 0.966	G = 0.961	0.762	0.878	G
				A = 0.033	A = 0.038
rs520806	1	74043276	C/T	C = 0.631	C = 0.664	0.324	1.155	T
				T = 0.368	T = 0.335
rs522759	1	74043517	T/C	T = 0.724	T = 0.752	0.361	1.154	C
				C = 0.275	C = 0.247
rs545664	1	74043712	G/A	G = 0.534	G = 0.524	0.794	0.961	G
				A = 0.465	A = 0.475
rs545721	1	74043734	C/T	C = 0.534	C = 0.479	0.182	0.803	C
				T = 0.465	T = 0.520
rs536355	1	74044111	G/A	G =	G =
				A =	A =
rs553044	1	74044508	G/T	G = 0.471	G = 0.490	0.594	1.079	T
				T = 0.528	T = 0.509
rs581353	1	74045321	A/G	A = 0.632	A = 0.647	0.666	1.064	G
				G = 0.367	G = 0.352
rs496008	1	74045741	T/A	T = 0.824	T = 0.822	0.947	0.988	T
				A = 0.175	A = 0.177
rs7366854	1	74046600	C/T	C = 0.847	C = 0.854	0.788	1.057	T
				T = 0.152	T = 0.145
rs560808	1	74048168	C/A	C = 0.593	C = 0.614	0.530	1.093	A
				A = 0.406	A = 0.385
rs485929	1	74048220	A/G	A = 0.692	A = 0.715	0.481	1.113	G
				G = 0.307	G = 0.284
rs477134	1	74048849	T/G	T = 0.587	T = 0.612	0.464	1.110	G
				G = 0.412	G = 0.387
rs505634	1	74049586	G/A	G = 0.939	G = 0.948	0.664	1.177	A
				A = 0.060	A = 0.051
rs542136	1	74049795	G/A	G =	G =
				A =	A =
rs545680	1	74050175	T/C	T = 0.707	T = 0.714	0.826	1.035	C
				C = 0.292	C = 0.285
rs522042	1	74051017	G/A	G =	G =
				A =	A =
rs575961	1	74051145	C/T	C = 0.979	C = 0.963	0.261	0.547	C
				T = 0.020	T = 0.036
rs792321	1	74051903	A/G	A = 0.667	A = 0.672	0.877	1.025	G
				G = 0.332	G = 0.327
rs524306	1	74052188	T/A	T = 0.517	T = 0.478	0.260	0.854	T
				A = 0.482	A = 0.521
rs495027	1	74052194	A/C	A = 0.562	A = 0.500	0.082	0.778	A
				C = 0.437	C = 0.499
rs525358	1	74053239	A/G	A = 0.127	A = 0.132	0.833	1.050	G
				G = 0.872	G = 0.867
rs471496	1	74053841	G/A	G = 0.097	G = 0.096	0.984	0.994	G
				A = 0.902	A = 0.903
rs504866	1	74055175	C/T	C = 0.604	C = 0.506	0.032	0.672	C
				T = 0.395	T = 0.493
rs532396	1	74056827	T/C	T = 0.960	T = 0.963	0.879	1.070	C
				C = 0.039	C = 0.036
rs533371	1	74056947	G/A	G = 0.510	G = 0.510	0.986	1.002	G
				A = 0.489	A = 0.489
rs567060	1	74058299	A/G	A = 0.699	A = 0.697	0.966	0.993	A
				G = 0.300	G = 0.302
rs4650251	1	74063483	A/G	A = 0.521	A = 0.477	0.213	0.839	A
				G = 0.478	G = 0.522
rs3753183	1	74069034	G/T	G = 0.080	G = 0.042	0.031	0.503	G
				T = 0.919	T = 0.957
rs518769	1	74069847	A/G	A = 0.873	A = 0.870	0.908	0.974	A
				G = 0.126	G = 0.129
rs474215	1	74070186	T/C	T = 0.485	T = 0.434	0.134	0.813	T
				C = 0.514	C = 0.565
AI	1	74071042	T/C	T = 0.048	T = 0.031	0.381	0.635	T
				C = 0.951	C = 0.968
rs500203	1	74071586	T/A	T = 0.453	T = 0.423	0.381	0.885	T
				A = 0.546	A = 0.576
rs532221	1	74071885	T/A	T = 0.722	T = 0.822	˜0.001	1.776	A
				A = 0.277	A = 0.177
rs539534	1	74072672	C/T	C = 0.536	C = 0.576	0.353	1.174	T
				T = 0.463	T = 0.423
rs531412	1	74072720	G/A	G = 0.740	G = 0.765	0.525	1.141	A
				A = 0.259	A = 0.234
rs9970514	1	74073693	C/G	C = 0.443	C = 0.462	0.576	1.083	G
				G = 0.556	G = 0.537
rs568049	1	74074438	C/T	C = 0.773	C = 0.777	0.914	1.023	T
				T = 0.226	T = 0.222
rs9727250	1	74077515	T/C	T = 0.073	T = 0.059	0.499	0.796	T
				C = 0.926	C = 0.940
rs792323	1	74077529	C/T	C = 0.820	C = 0.824	0.881	1.029	T
				T = 0.434	T = 0.406
rs3765651	1	74079297	A/C	A = 0.704	A = 0.704	0.996	0.999	C
				C = 0.295	C = 0.295
rs3765654	1	74079646	C/G	C = 0.745	C = 0.673	0.031	0.705	C
				G = 0.254	G = 0.326
rs481387	1	74080385	C/T	C = 0.479	C = 0.462	0.622	0.934	C
				T = 0.520	T = 0.537
rs483259	1	74080564	T/C	T = 0.636	T = 0.660	0.478	1.110	C
				C = 0.363	C = 0.339
rs2034453	1	74082116	A/G	A = 0.172	A = 0.150	0.463	0.852	A
				G = 0.827	G = 0.849
rs7536997	1	74082887	G/A	G = 0.947	G = 0.955	0.727	1.194	A
				A = 0.052	A = 0.044
rs792324	1	74083006	T/C	T = 0.070	T = 0.060	0.633	0.850	T
				T = 0.037	T = 0.044
rs792324	1	74083006	T/C	C = 0.929	C = 0.939	0.633	0.850	T
				C = 0.962	C = 0.955
rs6660350	1	74083486	C/T	C = 0.192	C = 0.159	0.259	0.792	C
				T = 0.807	T = 0.840
rs492302	1	74084074	G/C	G =	G =
				C =	C =
rs10493539	1	74085512	A/G	A = 0.385	A = 0.322	0.124	0.759	A
				G = 0.614	G = 0.677
rs496720	1	74088648	G/A	G = 0.960	G = 0.969	0.635	1.285	A
				A = 0.039	A = 0.030
rs570631	1	74089790	T/A	T = 0.384	T = 0.373	0.769	0.953	T
				A = 0.615	A = 0.626
rs4593767	1	74093028	G/A	G = 0.300	G = 0.260	0.236	0.821	G
				A = 0.699	A = 0.739
rs576802	1	74094231	T/A	T = 0.833	T = 0.865	0.209	1.282	A
				A = 0.166	A = 0.134
rs518574	1	74100973	A/G	A = 0.966	A = 0.968	0.880	1.069	G
				G = 0.033	G = 0.031
rs524252	1	74102532	C/T	C = 0.839	C = 0.840	0.966	1.008	T
				T = 0.160	T = 0.159
rs792327	1	74103456	G/A	G = 0.963	G = 0.978	0.477	1.720	A
				A = 0.037	A = 0.022
rs792328	1	74103887	C/A	C =	C =
				A =	A =
rs2039407	1	74104305	A/T	A = 0.945	A = 0.942	0.872	0.937	A
				T = 0.054	T = 0.057
rs503770	1	74105381	T/C	T = 0.824	T = 0.825	0.946	1.013	C
				C = 0.175	C = 0.174
rs503904	1	74105440	A/G	A = 0.814	A = 0.809	0.870	0.970	A
				G = 0.185	G = 0.190
rs514012	1	74107016	A/G	A = 0.821	A = 0.801	0.473	0.880	A
				G = 0.178	G = 0.198
rs1412827	1	74107532	A/G	A = 0.365	A = 0.387	0.544	1.101	G
				G = 0.634	G = 0.612
rs473834	1	74112969	G/A	G = 0.178	G = 0.185	0.803	1.046	A
				A = 0.821	A = 0.814
rs480267	1	74113659	A/G	A = 0.332	A = 0.364	0.439	1.153	G
				G = 0.667	G = 0.635
rs572180	1	74119134	G/T	G = 0.845	G = 0.850	0.816	1.047	T
				T = 0.154	T = 0.149
rs1333029	1	74119257	G/A	G = 0.961	G = 0.977	0.294	1.732	A
				A = 0.038	A = 0.022
rs485414	1	74119377	A/G	A = 0.897	A = 0.923	0.233	1.376	G
				G = 0.102	G = 0.076
rs1412823	1	74119701	A/T	A = 0.761	A = 0.761	0.995	0.999	T
				T = 0.238	T = 0.238
rs2027013	1	74120888	T/G	T = 0.093	T =
				G = 0.907	G =
rs548881	1	74128480	C/T	C = 0.920	C = 0.898	0.361	0.768	C
				T = 0.079	T = 0.101
rs792329	1	74130625	C/T	C = 0.754	C = 0.756	0.951	1.010	T
				T = 0.246	T = 0.244

Allelotyping results were considered significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The assay failed for those SNPs in which the allele frequency is blank. The combined allelotyping p-values for males and females were plotted in FIG. 5A and separately for females and males in FIGS. 5B and 5C, respectively. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele frequency in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIGS. 5A, 5B and 5C can be determined by consulting Table 34 or 35. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.

To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line (or generally top-most curve, e.g., see peak in left-most graph just to the left of position 92150000) provides a local test for excess statistical significance to identify regions of association. This was created by use of a 10 kb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10⁻⁸ were truncated at that value.

Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.

Example 10

REPS2 Proximal SNPs

It has been discovered that a polymorphic variation (rs1904528) in the untranslated region of a gene encoding presynaptic cytomatrix protein (REPS2) is associated with the occurrence of melanoma. See Table 3. Subsequently, one-hundred-three allelic variants located within or nearby the target genes were identified and subsequently allelotyped in melanoma case and control sample sets as described in Examples 1 and 2. Several SNPs, designated by SNP_ID “AJ”, “AK”, and “AL” in column 1 of Table 36, are novel and were identified through SNP discovery methods using dye terminator sequencing. Methods of diedeoxynucleotide chain termination chemistry derived sequencing are described by Sanger et al. (Proc. Nat. Acad. Sci. USA 74, 5463-5467, 1997). Briefly, terminators are labeled with fluorescent dyes for automated detection. Fluorescein is measured by an argon ion laser in the sequencing instrument, which transfers light energy to a rhodamine acceptor dye. Each acceptor dye emits light at a characteristic wavelength for detection, identifying the nucleotide that terminated extension of the DNA fragment. Novel SNPs are identified when sequence from multiple samples are compared on one or more strands. The forward and reverse primers used to identify AJ are GCTTTAGGATAGGGAGGAATGG and CCCAGCGCCAGGTAACTAAC, respectively. The forward and reverse primers used to identify AL are CCACCCTTCCTCTGACTGTT and ACAACCCCATCAAAAAGTGG, respectively. The polymorphic variants are set forth in Table 36. The chromosome position provided in column four of Table 36 is based on Genome “Build 34” of NCBI's GenBank and dbSNP build “119”.

TABLE 36
		Position			Allele
	Chromo-	in SEQ	Chromosome	Allele	Present in	IUPAC
dbSNP rs#	some	ID NO: 7	Position	Variants	SEQ ID NO: 7	Code
rs1904525	X	223	16315373	T/C	C	Y
rs5924557	X	790	16315940	C/T	C	Y
rs5924616	X	834	16315984	A/T	T	W
rs5924617	X	1,167	16316317	G/A	G	R
rs7883612	X	1,372	16316522	G/A	G	R
rs5924618	X	2,448	16317598	C/T	C	Y
rs5924619	X	5,291	16320441	T/C	T	Y
AJ	X	10,537	16325687	G/T	T	K
rs5901596	X	13,495	16328645	—/TGG	G	N
rs7878645	X	13,861	16329011	T/C	C	Y
rs5924564	X	14,299	16329449	C/G	C	S
rs5924535	X	23,962	16339112	A/G	G	R
AK	X	25,216	16340366	A/C	A	M
rs6629197	X	33,304	16348454	C/T	T	Y
rs7060904	X	40,831	16355981	G/T	T	K
rs4828523	X	41,424	16356574	A/G	G	R
rs5924568	X	41,898	16357048	C/G	G	S
rs5924569	X	41,984	16357134	A/G	A	R
rs1904528	X	50,013	16365163	C/T	G	R
rs5924570	X	50,632	16365782	C/G	G	S
rs1904527	X	54,491	16369641	A/G	C	Y
rs2052763	X	55,422	16370572	G/A	C	Y
rs1549529	X	62,416	16377566	A/G	A	R
rs5924573	X	64,172	16379322	A/G	A	R
rs5901600	X	69,271	16384421	—/T	T	N
rs2288304	X	70,244	16385394	T/C	T	Y
rs4240072	X	71,687	16386837	A/G	T	Y
rs3055191	X	73,571	16388721	—/	G	N
rs6632943	X	78,150	16393300	T/C	C	Y
rs5924580	X	80,031	16395181	G/A	A	R
rs4828544	X	82,908	16398058	T/C	C	Y
rs1807412	X	85,218	16400368	A/G	C	Y
rs2010456	X	85,269	16400419	G/A	G	R
rs5969758	X	87,416	16402566	G/A	G	R
rs1965051	X	89,285	16404435	A/G	T	Y
re9887218	X	89,644	16404794	T/C	C	Y
rs1426800	X	92,647	16407797	G/A	T	Y
rs5969759	X	102,294	16417444	A/G	G	R
rs6527766	X	103,071	16418221	T/C	C	Y
rs1365529	X	106,614	16421764	T/C	C	Y
rs5924582	X	107,231	16422381	G/A	A	R
rs2114458	X	109,076	16424226	G/A	A	R
rs5924583	X	109,520	16424670	T/C	C	Y
rs5924545	X	111,210	16426360	G/A	A	R
rs5969761	X	113,905	16429055	C/T	T	Y
rs6629201	X	114,439	16429589	C/T	C	Y
rs6629202	X	114,544	16429694	C/T	T	Y
rs5924584	X	114,886	16430036	A/G	G	R
rs5924585	X	115,261	16430411	A/G	G	R
rs933946	X	116,964	16432114	T/C	G	R
AL	X	119,368	16434518	C/T	C	Y
rs5969762	X	122,315	16437465	A/G	G	R
rs713355	X	126,768	16441918	T/C	G	R
rs1365530	X	127,291	16442441	G/C	C	S
rs1961490	X	127,365	16442515	A/T	A	W
rs6527769	X	128,866	16444016	C/G	C	S
rs2006847	X	133,171	16448321	A/G	G	R
rs2382813	X	136,375	16451525	A/G	G	R
rs2033120	X	136,531	16451681	C/G	C	S
rs2162394	X	136,895	16452045	A/G	T	Y
rs1346246	X	138,428	16453578	C/A	G	K
rs1365527	X	139,052	16454202	G/C	G	S
rs1426801	X	139,255	16454405	T/C	G	R
rs5924546	X	140,611	16455761	G/C	C	S
rs5924547	X	142,144	16457294	G/C	C	S
rs1365528	X	144,730	16459880	G/A	C	Y
rs4828524	X	147,464	16462614	A/G	A	R
rs5924588	X	148,435	16463585	C/T	T	Y
rs5969764	X	154,005	16469155	C/T	T	Y
rs5924589	X	158,068	16473218	T/G	T	K
rs5924590	X	160,286	16475436	G/T	T	K
rs5924591	X	163,778	16478928	G/T	T	K
rs5924592	X	165,697	16480847	A/G	A	R
rs5924548	X	165,741	16480891	G/A	G	R
rs5924593	X	165,785	16480935	C/G	G	S
rs4828547	X	167,511	16482661	A/G	G	R
rs714070	X	168,378	16483528	A/G	C	Y
rs5969768	X	175,465	16490615	T/C	C	Y
rs4828526	X	176,485	16491635	G/A	G	R
rs5969738	X	177,613	16492763	G/A	A	R
rs5924595	X	178,208	16493358	G/A	A	R
rs5924549	X	178,275	16493425	A/G	G	R
rs4828528	X	179,554	16494704	T/C	C	Y
rs5969769	X	180,382	16495532	G/A	A	R
rs4007744	X	182,507	16497657	C/T	T	Y
rs2891073	X	184,214	16499364	T/C	C	Y
rs5924599	X	185,900	16501050	C/G	G	S
rs1549531	X	191,011	16506161	G/A	A	R
rs5924601	X	192,972	16508122	A/G	G	R
rs5901609	X	195,135	16510285	C/—	C	N
rs5969739	X	196,266	16511416	C/T	C	Y
rs5924602	X	197,399	16512549	T/G	T	K
rs1426798	X	198,610	16513760	A/C	A	M
rs7891150	X	198,851	16514001	C/T	T	Y
rs4828550	X	199,052	16514202	G/A	A	R
rs5924603	X	200,639	16515789	T/C	T	Y
rs1807947	X	209,336	16524486	A/G	T	Y
rs954253	X	209,379	16524529	A/G	A	R
rs2382814	X	210,011	16525161	T/G	T	K
rs1896178	X	210,380	16525530	A/G	C	Y
rs1896177	X	210,400	16525550	A/G	T	Y
rs5924605	X	210,554	16525704	C/G	G	S
rs5924606	X	213,071	16528221	A/G	A	R

Assay for Verifying and Allelotyping SNPs

The methods used to verify and allelotype the one-hundred-three proximal SNPs of Table 36 are the same methods described in Examples 1 and 2 herein. The primers and probes used in these assays are provided in Table 37 and Table 38, respectively.

	TABLE 37
	dbSNP rs #	Forward PCR primer	Reverse PCR primer
	rs1904525	CAAGTTACTGTCTCAGCCTG	CAAGTTACTGTCTCAGCCTG
	rs5924557	ACACTCAGGCTACTTCTTAC	ACACTCAGGCTACTTCTTAC
	rs5924616	AGCACACGTAATTTGGGTCC	AGCACACGTAATTTGGGTCC
	rs5924617	AAAGAGCAGTTCCCCTACAC	AAAGAGCAGTTCCCCTACAC
	rs7883612	CCTCCATGATATGGTTTGTC	CCTCCATGATATGGTTTGTC
	rs5924618	TGATCCTCCCACCTCAGGTT	TGATCCTCCCACCTCAGGTT
	rs5924619	AGATGGCTGTTGACTGAGAG	AGATGGCTGTTGACTGAGAG
	AJ	CAGAGTGTTCAGGGTGGTAT	CAGAGTGTTCAGGGTGGTAT
	rs5901596	AAAGTCAGCAACCAGCAGAC	AAAGTCAGCAACCAGCAGAC
	rs7878645	TTGCAGTGAGCCAAGATCAC	TTGCAGTGAGCCAAGATCAC
	rs5924564	GATGAACCTACATTGACACC	GATGAACCTACATTGACACC
	rs5924535	AGGTTGCTATGGGAATGGAG	AGGTTGCTATGGGAATGGAG
	AK	GGGACAGTTTTCTTGATTTCC	GGGACAGTTTTCTTGATTTCC
	rs6629197	ACTTCCCAGACGGGATGGCT	ACTTCCCAGACGGGATGGCT
	rs7060904	CCAATTGGTAGACAACCAAG	CCAATTGGTAGACAACCAAG
	rs4828523	GAGTCTCCTGCTCTTGAAAG	GAGTCTCCTGCTCTTGAAAG
	rs5924568	GATGCGATCACTCACGTCTG	GATGCGATCACTCACGTCTG
	rs5924569	ACATAGGAAGACCCCCATCT	ACATAGGAAGACCCCCATCT
	rs1904528	GCTATCTCTTTCACATTGCTC	GCTATCTCTTTCACATTGCTC
	rs5924570	TCTAATATGTGTCGGCTCTG	TCTAATATGTGTCGGCTCTG
	rs1904527	TCCATCCAGATCATTGCATG	TCCATCCAGATCATTGCATG
	rs2052763	TGTTATGAAATGGAGCCACG	TGTTATGAAATGGAGCCACG
	rs1549529	AGGATAGTAATGGCCTGGTG	AGGATAGTAATGGCCTGGTG
	rs5924573	GGGAGTAGCTTACATCTTGG	GGGAGTAGCTTACATCTTGG
	rs5901600	CATACCAAGGATTACAATGTC	CATACCAAGGATTACAATGTC
	rs2288304	GGGAGTGGATTCTAATGTTC	GGGAGTGGATTCTAATGTTC
	rs4240072	AAGCTAGCCCCCTGATAAAG	AAGCTAGCCCCCTGATAAAG
	rs3055191	CCCTCCTCTCTTCTCTACTG	CCCTCCTCTCTTCTCTACTG
	rs6632943	TTGACAAAGGAACACTGAGG	TTGACAAAGGAACACTGAGG
	rs5924580	CCGCAAACTATTGCAAGGAC	CCGCAAACTATTGCAAGGAC
	rs4828544	TATGAGGCATCAAGAGTAGC	TATGAGGCATCAAGAGTAGC
	rs1807412	AGTTCGAAACTAACCTGGCC	AGTTCGAAACTAACCTGGCC
	rs2010456	GTGGCTCACTTACGCCTATA	GTGGCTCACTTACGCCTATA
	rs5969758	AGCTATACCTTGATGCCTGC	AGCTATACCTTGATGCCTGC
	rs1965051	TGGTTAAACAGCAGTGTCTG	TGGTTAAACAGCAGTGTCTG
	rs9887218	CCATGTTTCCAAAGACAGGG	CCATGTTTCCAAAGACAGGG
	rs1426800	GTGGGATTCACTTCCTAAGG	GTGGGATTCACTTCCTAAGG
	rs5969759	ACAACTGGCACCATTTTAGC	ACAACTGGCACCATTTTAGC
	rs6527766	ATTCCACCCGTCAGCATAAG	ATTCCACCCGTCAGCATAAG
	rs1365529	TTTGCATGCACCCTAAAGAG	TTTGCATGCACCCTAAAGAG
	rs5924582	ATGATCGTACCACTGAACCC	ATGATCGTACCACTGAACCC
	rs2114458	TAATGTGGAGAACTCACAGG	TAATGTGGAGAACTCACAGG
	rs5924583	GGAGTTCAAGACCAACCTAG	GGAGTTCAAGACCAACCTAG
	rs5924545	TACTTGAGTGGCAAGTCAGG	TACTTGAGTGGCAAGTCAGG
	rs5969761	CGTGTTTGTGTTTCAGTATT	CGTGTTTGTGTTTCAGTATT
	rs6629201	CACTCACTCTCTGACTTACC	CACTCACTCTCTGACTTACC
	rs6629202	CTCTGCCTTTTCTATGTTTC	CTCTGCCTTTTCTATGTTTC
	rs5924584	ACTATTGTGTCCCAACTGCC	ACTATTGTGTCCCAACTGCC
	rs5924585	GTATCCATCCCCTCAAGCAT	GTATCCATCCCCTCAAGCAT
	rs933946	CCTTTAGTTCCTACCTTTGC	CCTTTAGTTCCTACCTTTGC
	AL	AATACCTGCAGGCAGGTAAG	AATACCTGCAGGCAGGTAAG
	rs5969762	TTGGGATTGGAGACACATGG	TTGGGATTGGAGACACATGG
	rs713355	ATGTGGTCTATCAGAGCTAG	ATGTGGTCTATCAGAGCTAG
	rs1365530	CCTCTTCTCAAAACAGTTCTG	CCTCTTCTCAAAACAGTTCTG
	rs1961490	TAAAAACCCTGAGGGAGTTC	TAAAAACCCTGAGGGAGTTC
	rs6527769	TCTGAACAAAGCTGCAGCTG	TCTGAACAAAGCTGCAGCTG
	rs2006847	CACTGGAATCTGATCGTAGC	CACTGGAATCTGATCGTAGC
	rs2382813	ACCTAATTCAGCAGAGCACC	ACCTAATTCAGCAGAGCACC
	rs2033120	TTCTAGGACAGCAAAGGAGG	TTCTAGGACAGCAAAGGAGG
	rs2162394	TTTTTGCTGGTAGGGATGGG	TTTTTGCTGGTAGGGATGGG
	rs1346246	GTTTATATGCAGCACCTGGG	GTTTATATGCAGCACCTGGG
	rs1365527	ATGGTCTGTTTGAGCCTATC	ATGGTCTGTTTGAGCCTATC
	rs1426801	TGGTAGAACTGCAGTGTAAG	TGGTAGAACTGCAGTGTAAG
	rs5924546	ACCTCTGAAAACCTTCTTCG	ACCTCTGAAAACCTTCTTCG
	rs5924547	CACAGGCATCTGAGGAAATG	CACAGGCATCTGAGGAAATG
	rs1365528	CCTTTCTCACCCTTGCAAAC	CCTTTCTCACCCTTGCAAAC
	rs4828524	CCTGGAATGCAGCTGAAATG	CCTGGAATGCAGCTGAAATG
	rs5924588	TTAAAGTGCACAATTCAGTG	TTAAAGTGCACAATTCAGTG
	rs5969764	GGCAACCACTAACCTATTTTG	GGCAACCACTAACCTATTTTG
	rs5924589	ATTTTTGCCATCATCTTCCC	ATTTTTGCCATCATCTTCCC
	rs5924590	GCTGACTAGACAGATCTGAG	GCTGACTAGACAGATCTGAG
	rs5924591	GCACAACTTTCTTCCCAATAG	GCACAACTTTCTTCCCAATAG
	rs5924592	TAGCCAGGATGGTCTCGATC	TAGCCAGGATGGTCTCGATC
	rs5924548	CAGGTATGTGTCCGTTGTTC	CAGGTATGTGTCCGTTGTTC
	rs5924593	ATTACAAGCGTGAGCCATCG	ATTACAAGCGTGAGCCATCG
	rs4828547	AAGATTCTTCAGATGTGGCC	AAGATTCTTCAGATGTGGCC
	rs714070	GACAGCCAAGAGTGAACTAG	GACAGCCAAGAGTGAACTAG
	rs5969768	GATATTTGAAAGCTGACAAC	GATATTTGAAAGCTGACAAC
	rs4828526	CAGCAAGGACCTATAGTCCC	CAGCAAGGACCTATAGTCCC
	rs5969738	GTCAATTTCGTTGATCTTTGC	GTCAATTTCGTTGATCTTTGC
	rs5924595	GACACTTATTGATAAAGAGC	GACACTTATTGATAAAGAGC
	rs5924549	GAAGTACTCAGCATTTTGCTC	GAAGTACTCAGCATTTTGCTC
	rs4828528	TCCTATGACCCTGCCACATC	TCCTATGACCCTGCCACATC
	rs5969769	TCTACGCTTAAACCCATCGC	TCTACGCTTAAACCCATCGC
	rs4007744	CCCAAGTAGCTGGGACTACA	CCCAAGTAGCTGGGACTACA
	rs2891073	GACAGCAGAGAAGAGAAATG	GACAGCAGAGAAGAGAAATG
	rs5924599	CTCTGAATCCTTGTGTCAGG	CTCTGAATCCTTGTGTCAGG
	rs1549531	TTAGGAAACACTGCCTGGTC	TTAGGAAACACTGCCTGGTC
	rs5924601	ACACAGCACCTACTACAGTG	ACACAGCACCTACTACAGTG
	rs5901609	TGAATGAGTAACACTCAGGC	TGAATGAGTAACACTCAGGC
	rs5969739	CCCTTCTGATAACTCCTTCG	CCCTTCTGATAACTCCTTCG
	rs5924602	ACTTCAAACTGCACAGTCAC	ACTTCAAACTGCACAGTCAC
	rs1426798	ATTCACAGAGGCTTAGCAGG	ATTCACAGAGGCTTAGCAGG
	rs7891150	GGCTCTTCTTTCAGAGAGAG	GGCTCITCTTTCAGAGAGAG
	rs4828550	ACTCCAGCCTGGGCAACAAA	ACTCCAGCCTGGGCAACAAA
	rs5924603	GTTGCTAACATCTCCCACAG	GTTGCTAACATCTCCCACAG
	rs1807947	AACCATAGGGTGAGTTTGGG	AACCATAGGGTGAGTTTGGG
	rs954253	ATGTTCGTCTCACAGTGGAC	ATGTTCGTCTCACAGTGGAC
	rs2382814	TCAGCAAGTCCTACCAGTTC	TCAGCAAGTCCTACCAGTTC
	rs1896178	AGGTTCACGCCATTCTCCTG	AGGTTCACGCCATTCTCCTG
	rs1896177	AGGTTCACGCCATTCTCCTG	AGGTTCACGCCATTCTCCTG
	rs5924605	AGAGTGAGACTCTGTCTCAG	AGAGTGAGACTCTGTCTCAG
	rs5924606	GAGCCCAAUAACTCCAGTG	GAGCCCAATTAACTCCAGTG

	TABLE 38
	Term
	dbSNP rs #	Extend Primer	Mix
	rs1904525	TCCCAGCACTTTGGGAG	ACT
	rs5924557	TTCTATCCCCTTACTTCC	ACG
	rs5924616	GAAGACAGCAATTTCCT	CGT
	rs5924617	TAAGACGTGCCTATGCT	ACG
	rs7883612	TTTGTCTGTGTCCCCAC	ACG
	rs5924618	CTAGGACTACAGGTGCA	ACG
	rs5924619	AAGGACACGACAGAAAG	ACT
	AJ	CCTCGTCAGACATGGCTCA	CGT
	rs5901596	GGTGGTGGTGTGGTGGTG	ACT
	rs7878645	GAGCCAAGATCACGCCACC	ACT
	rs5924564	CTCATTATTCCCCAAAGT	ACT
	rs5924535	GGGAATGGAGATAAATTCAA	ACT
	AK	TTCTTGATTTCCAACTGATT	ACT
	rs6629197	ACGGGATGGCTGCCGGG	ACG
	rs7060904	GACAACCAAGATGAAAAAC	CGT
	rs4828523	AGATTAGCATATTGATAGATTGC	ACT
	rs5924568	AGGCAGGAGGATCACTT	ACT
	rs5924569	TAGCTGGGCATGTTGGT	ACT
	rs1904528	TCACATTGCTCTGCACTTTTG	ACG
	rs5924570	CACGAGTGTGTTTTTATCT	ACT
	rs1904527	ACTCCTTTTTACTGCTGGGTA	ACT
	rs2052763	GAGTGAGTCCCTGTGCA	ACG
	rs1549529	TTTGGGAGGCCAAGGTA	ACT
	rs5924573	AGCAAAATCTTGGCCGGGC	ACT
	rs5901600	GGATTACAATGTCTTTTTTTTTT	ACG
	rs2288304	TGAAAAGAGAACAGATTAGTC	ACT
	rs4240072	GATGACTGCCACCTGCT	ACT
	rs3055191	CACTGGTTTTTTGTTTGTTT	ACT
	rs6632943	GGGGGATTGGGTTGGAC	ACT
	rs5924580	GTTCTCACTCATAGGTGGGAA	ACG
	rs4828544	AAGAGTAGCCAAACTCATA	ACT
	rs1807412	CAACATGGTAAAACCCC	ACT
	rs2010456	AGGCGGAGGCGGGTGGA	ACG
	rs5969758	ATGCCTGCAGGGTACAC	ACG
	rs1965051	CAGCAGTGTCTGAGGATTCAA	ACT
	rs9887218	CTTGAAGCGTTACCGCCTG	ACT
	rs1426800	CTAAGGAAAGCTCATGAC	ACG
	rs5969759	TCTTTCCCTTGATCTCAGGC	ACT
	rs6527766	CCCAGCACTGCACAAGCTG	ACT
	rs1365529	TTTTGTTGGCTGAGCAGAGAT	ACT
	rs5924582	GAACCCCAGCCTGGGTGA	ACG
	rs2114458	CAGCCCTGACAGAAAGAGC	ACG
	rs5924583	GCCAACATGGTGAAACCCC	ACT
	rs5924545	GGACCACTGAACCTCTCATT	ACG
	rs596976	TTCAGTATTTAACCAAAAAGTTTAAA	ACG
	rs6629201	CTTCCAGTCCTGCAAGCTC	ACG
	rs6629202	CTTTCTTTCTTCCTTTCTTCCTT	ACG
	rs5924584	TATTCAGTACAGGAACATGCC	ACT
	rs5924585	CCTTTGAGTTACAAACAATCCA	ACT
	rs933946	GATGTTTTTAACAGACTACAGGA	ACT
	AL	AGGTAAGGCCTCACCATCAA	ACG
	rs5969762	AAGGGAATTAATAGCTGGCAAA	ACT
	rs713355	GTTATATTTAACAAGCACAGAAAA	ACT
	rs1365530	ATTAATGCCCAACTGATAAAAATA	ACT
	rs1961490	AATGTGATTTGGGGCCCTCA	CGT
	rs6527769	CTGCAGCTGATTTAGGTCTCA	ACT
	rs2006847	GGAAATGACAGGAAGCTGAAC	ACT
	rs2382813	GCAGAGCACCATGCACAATG	ACT
	rs2033120	GCAGGTAGGAGCAGGTAATG	ACT
	rs2162394	GGGGTGAGCCCTGCTGGT	ACT
	rs1346246	GGCTAGTACAGAACACATCAA	CGT
	rs1365527	GAGCCTATCTTAGTGCCCCT	ACT
	rs1426801	GATAGGATAACGAGGATACCAT	ACT
	rs5924546	TTAGAGTGGCATTTATGAAGTTA	ACT
	rs5924547	CTGAGGAAATGACAGACAGC	ACT
	rs1365528	CTCTCCACCCCGACCCC	ACG
	rs4828524	GAATGCAGCTGAAATGACAGAA	ACT
	rs5924588	TUCAGAATATTTTCATCCCCC	ACG
	rs5969764	CTGCAGATTTTCCTTTTCTGAA	ACG
	rs5924589	CATCATCTTCCCTCCCCCA	ACT
	rs5924590	CTGAGAAAGCAGGGAGTAAC	CGT
	rs5924591	TCTACATTTTTACAGCGTAGCA	CGT
	rs5924592	GTCTCGATCTCCTGACCTC	ACT
	rs5924548	GCCTGGCGCGATGGCTCA	ACG
	rs5924593	TATGCCAACTCTTACAATGAGA	ACT
	rs4828547	AGATGTGGCCAGATTATTTTAG	ACT
	rs714070	GTATGCTTGGTGGCTTATTGA	ACT
	rs5969768	ACAGGTTAAGTATCCAAAATCC	ACT
	rs4828526	GGACCTATAGTCCCAGCTAC	ACG
	rs5969738	CAACTTTTCAACTATTTTCTCTG	ACG
	rs5924595	TGATAAAGAGCAAAATGCTGAG	ACG
	rs5924549	TCCTAGTAACTAATTCAAAAGAAA	ACT
	rs4828528	GGGAACTCAGAGGCTGGCA	ACT
	rs5969769	GCGCCATCAAAACAGAACAC	ACG
	rs4007744	GCTGGGACTACAGGCGCC	ACG
	rs2891073	GAAATGAGGATTCCATTGCTCA	ACT
	rs5924599	ATCCTTGTGTCAGGATTCTAC	ACT
	rs1549531	ACTGCCTGGTCTATCTCCC	ACG
	rs5924601	ACTACAGTGGGCCTCCCC	ACT
	rs5901609	ACACTCAGGCCTGAGAATAC	ACG
	rs5969739	TAACTCCTTCGACCACAGTC	ACG
	rs5924602	AAACTGCACAGTCACCAGAAA	ACT
	rs1426798	CTTAGCAGGTGGATGGGGT	ACT
	rs7891150	CTTTCAGAGAGAGTGGGCC	ACG
	rs4828550	GGGCAACAAAGCGAGACTC	ACG
	rs5924603	CACAGAACCTGCTGCTTTTC	ACT
	rs1807947	GGTCCACTGTGAGACGAAC	ACT
	rs954253	GGACTCCCAAACTCACCCT	ACT
	rs2382814	CTACCAGTTCTAGATTCAAGATT	ACT
	rs1896178	AGTAGCTGGGACTACAGGC	ACT
	rs1896177	CTCCTGCCTCAGCCTCCC	ACT
	rs5924605	AACCCTCAATGCCATCCCC	ACT
	rs5924606	TAAGCTCAAATTGCAGAAGCC	ACT

Genetic Analysis

Allelotyping results are shown for female (F) and male (M) cases and controls in Table 39 and Table 40, respectively. Allele frequency is noted in the fourth and fifth columns for melanoma pools and control pools, respectively.

TABLE 39
Females
								Melanoma
	Chromo-	Chromosome		Female	Female	F	Odds	Associated
dbSNP rs#	some	Position	Alleles	Case AF	Control AF	p-Value	Ratio	Allele
rs1904525	X	16315373	T/C	T = 0.523	T = 0.575	0.129	1.233	C
				C = 0.476	C = 0.424
rs5924557	X	16315940	C/T	C = 0.654	C = 0.598	0.087	0.788	C
				T = 0.345	T = 0.401
rs5924616	X	16315984	A/T	A = 0.562	A = 0.505	0.095	0.797	A
				T = 0.437	T = 0.494
rs5924617	X	16316317	G/A	G = 0.730	G = 0.708	0.501	0.900	G
				A = 0.269	A = 0.291
rs7883612	X	16316522	G/A	G = 0.515	G = 0.520	0.897	1.017	A
				A = 0.484	A = 0.479
rs5924618	X	16317598	C/T	C = 0.339	C = 0.274	0.061	0.734	C
				T = 0.660	T = 0.725
rs5924619	X	16320441	T/C	T = 0.471	T = 0.355	0.001	0.618	T
				C = 0.528	C = 0.644
AJ	X	16325687	G/T	G = 0.059	G = 0.030	0.123	0.505	G
				T = 0.940	T = 0.969
rs5901596	X	16328645	—/TGG	— = 0.351	— = 0.350	0.979	0.996	—
				TGG = 0.648	TGG = 0.649
rs7878645	X	16329011	T/C	T = 0.400	T = 0.481	0.054	1.395	C
				C = 0.599	C = 0.518
rs5924564	X	16329449	C/G	C = 0.363	C = 0.260	0.002	0.619	C
				G = 0.636	G = 0.739
rs5924535	X	16339112	A/G	A = 0.687	A = 0.645	0.207	0.826	A
				G = 0.312	G = 0.354
AK	X	16340366	A/C	A = 0.744	A = 0.684	0.050	0.743	A
				C = 0.255	C = 0.315
rs6629197	X	16348454	C/T	C = 0.739	C = 0.758	0.525	1.102	T
				T = 0.260	T = 0.241
rs7060904	X	16355981	G/T	G = 0.478	G = 0.523	0.189	1.194	T
				T = 0.521	T = 0.476
rs4828523	X	16356574	A/G	A = 0.858	A = 0.906	0.040	1.592	G
				G = 0.141	G = 0.093
rs5924568	X	16357048	C/G	C = 0.825	C = 0.873	0.057	1.453	G
				G = 0.174	G = 0.126
rs5924569	X	16357134	A/G	A = 0.377	A = 0.266	˜0.001	0.599	A
				G = 0.622	G = 0.733
rs1904528	X	16365163	C/T	C = 0.254	C = 0.200	0.054	0.736	C
				T = 0.745	T = 0.799
rs5924570	X	16365782	C/G	C = 0.390	C = 0.390	0.994	1.001
				G = 0.609	G = 0.609
rs1904527	X	16369641	A/G	A = 0.543	A = 0.478	0.082	0.771	A
				G = 0.456	G = 0.521
rs2052763	X	16370572	G/A	G = 0.298	G = 0.219	0.006	0.661	G
				A = 0.701	A = 0.780
rs1549529	X	16377566	A/G	A = 0.437	A = 0.311	˜0.001	0.580	A
				G = 0.562	G = 0.688
rs5924573	X	16379322	A/G	A = 0.521	A = 0.413	0.008	0.646	A
				G = 0.478	G = 0.586
rs5901600	X	16384421	—/T	— = 0.849	— = 0.873	0.329	1.222	T
				— = 0.855	— = 0.885
rs5901600	X	16384421	—/T	T = 0.150	T = 0.126	0.329	1.222	T
				T = 0.144	T = 0.114
rs2288304	X	16385394	T/C	T = 0.729	T = 0.701	0.392	0.871	T
				C = 0.270	C = 0.298
rs4240072	X	16386837	A/G	A = 0.346	A = 0.229	˜0.001	0.562	A
				G = 0.653	G = 0.770
rs3055191	X	16388721	—/	— = 0.499	— = 0.488	0.770	0.959	—
				= 0.500	= 0.511
rs6632943	X	16393300	T/C	T = 0.461	T = 0.520	0.080	1.268	C
				C = 0.538	C = 0.479
rs5924580	X	16395181	G/A	G = 0.847	G = 0.794	0.049	0.693	G
				A = 0.152	A = 0.205
rs4828544	X	16398058	T/C	T = 0.783	T = 0.855	0.006	1.633	C
				C = 0.216	C = 0.144
rs1807412	X	16400368	A/G	A = 0.596	A = 0.620	0.506	1.107	G
				G = 0.403	G = 0.379
rs2010456	X	16400419	G/A	G = 0.022	G = 0.015	0.607	0.699	G
				A = 0.978	A = 0.985
rs5969758	X	16402566	G/A	G = 0.248	G = 0.192	0.041	0.719	G
				A = 0.751	A = 0.807
rs1965051	X	16404435	A/G	A = 0.341	A = 0.232	˜0.001	0.585	A
				G = 0.658	G = 0.767
rs9887218	X	16404794	T/C	T = 0.007	T = 0.043	0.069	6.157	C
				C = 0.993	C = 0.957
rs1426800	X	16407797	G/A	G = 0.752	G = 0.860	˜0.001	2.027	A
				A = 0.247	A = 0.139
rs5969759	X	16417444	A/G	A = 0.631	A = 0.681	0.124	1.245	G
				G = 0.368	G = 0.318
rs6527766	X	16418221	T/C	T = 0.801	T = 0.812	0.703	1.069	C
				C = 0.198	C = 0.187
rs1365529	X	16421764	T/C	T = 0.824	T = 0.890	0.008	1.738	C
				C = 0.175	C = 0.109
rs5924582	X	16422381	G/A	G = 0.800	G = 0.827	0.324	1.199	A
				A = 0.199	A = 0.172
rs2114458	X	16424226	G/A	G = 0.808	G = 0.852	0.081	1.366	A
				A = 0.191	A = 0.147
rs5924583	X	16424670	T/C	T = 0.701	T = 0.726	0.421	1.132	C
				C = 0.298	C = 0.273
rs5924545	X	16426360	G/A	G = 0.813	G = 0.868	0.029	1.510	A
				A = 0.186	A = 0.131
rs5969761	X	16429055	C/T	C = 0.760	C = 0.901	˜0.001	2.881	T
				T = 0.239	T = 0.098
rs6629201	X	16429589	C/T	C = 0.657	C = 0.625	0.339	0.871	C
				T = 0.342	T = 0.374
rs6629202	X	16429694	C/T	C = 0.704	C = 0.786	0.013	1.544	T
				T = 0.295	T = 0.213
rs5924584	X	16430036	A/G	A = 0.795	A = 0.873	0.001	1.779	G
				G = 0.204	G = 0.126
rs5924585	X	16430411	A/G	A = 0.870	A = 0.868	0.929	0.981	A
				G = 0.129	G = 0.131
rs933946	X	16432114	T/C	T = 0.835	T = 0.866	0.202	1.278	C
				C = 0.164	C = 0.133
AL	X	16434518	C/T	C = 0.820	C = 0.799	0.422	0.870	C
				T = 0.179	T = 0.200
rs5969762	X	16437465	A/G	A = 0.563	A = 0.577	0.731	1.055	G
				G = 0.436	G = 0.422
rs713355	X	16441918	T/C	T = 0.559	T = 0.559	0.995	1.001
				C = 0.440	C = 0.440
rs1365530	X	16442441	G/C	G = 0.798	G = 0.870	0.007	1.699	C
				C = 0.201	C = 0.129
rs1961490	X	16442515	A/T	A = 0.768	A = 0.722	0.121	0.783	A
				T = 0.231	T = 0.277
rs6527769	X	16444016	C/G	C = 0.388	C = 0.290	0.004	0.647	C
				G = 0.611	G = 0.709
rs2006847	X	16448321	A/G	A = 0.555	A = 0.556	0.981	1.003	G
				G = 0.444	G = 0.443
rs2382813	X	16451525	A/G	A = 0.876	A = 0.923	0.035	1.693	G
				G = 0.123	G = 0.076
rs2033120	X	16451681	C/G	C = 0.790	C = 0.864	0.008	1.695	G
				G = 0.209	G = 0.135
rs2162394	X	16452045	A/G	A = 0.310	A = 0.221	0.002	0.632	A
				G = 0.689	G = 0.778
rs1346246	X	16453578	C/A	C = 0.400	C = 0.303	0.002	0.652	C
				A = 0.599	A = 0.696
rs1365527	X	16454202	G/C	G = 0.817	G = 0.870	0.040	1.495	C
				C = 0.182	C = 0.129
rs1426801	X	16454405	T/C	T = 0.432	T = 0.477	0.321	1.200	C
				C = 0.567	C = 0.522
rs5924546	X	16455761	G/C	G = 0.366	G = 0.419	0.106	1.252	C
				C = 0.633	C = 0.580
rs5924547	X	16457294	G/C	G = 0.562	G = 0.541	0.519	0.917	G
				C = 0.437	C = 0.458
rs1365528	X	16459880	G/A	G = 0.221	G = 0.180	0.133	0.775	G
				A = 0.778	A = 0.819
rs4828524	X	16462614	A/G	A = 0.296	A = 0.205	0.001	0.614	A
				G = 0.703	G = 0.794
rs5924588	X	16463585	C/T	C = 0.676	C = 0.788	˜0.001	1.784	T
				T = 0.323	T = 0.211
rs5969764	X	16469155	C/T	C = 0.784	C = 0.861	0.003	1.720	T
				T = 0.215	T = 0.138
rs5924589	X	16473218	T/G	T = 0.340	T = 0.258	0.012	0.678	T
				G = 0.659	G = 0.741
rs5924590	X	16475436	G/T	G = 0.809	G = 0.869	0.016	1.572	T
				T = 0.190	T = 0.130
rs5924591	X	16478928	G/T	G = 0.844	G = 0.887	0.064	1.460	T
				T = 0.155	T = 0.112
rs5924592	X	16480847	A/G	A = 0.423	A = 0.422	0.980	0.997	A
				G = 0.576	G = 0.577
rs5924548	X	16480891	G/A	G = 0.748	G = 0.698	0.104	0.778	G
				A = 0.251	A = 0.301
rs5924593	X	16480935	C/G	C = 0.723	C = 0.782	0.051	1.380	G
				G = 0.276	G = 0.217
rs4828547	X	16482661	A/G	A = 0.807	A = 0.859	0.041	1.457	G
				G = 0.192	G = 0.140
rs714070	X	16483528	A/G	A = 0.566	A = 0.552	0.685	0.945	A
				G = 0.433	G = 0.447
rs5969768	X	16490615	T/C	T = 0.077	T = 0.078	0.959	1.014	C
				C = 0.922	C = 0.921
rs4828526	X	16491635	G/A	G = 0.221	G = 0.157	0.021	0.655	G
				A = 0.778	A = 0.842
rs5969738	X	16492763	G/A	G = 0.538	G = 0.566	0.431	1.117	A
				A = 0.461	A = 0.433
rs5924595	X	16493358	G/A	G = 0.772	G = 0.848	0.011	1.655	A
				A = 0.227	A = 0.151
rs5924549	X	16493425	A/G	A = 0.699	A = 0.777	0.011	1.502	G
				G = 0.300	G = 0.222
rs4828528	X	16494704	T/C	T = 0.317	T = 0.316	0.973	0.995	T
				C = 0.682	C = 0.683
rs5969769	X	16495532	G/A	G = 0.800	G = 0.878	0.003	1.801	A
				A = 0.199	A = 0.121
rs4007744	X	16497657	C/T	C = 0.532	C = 0.636	0.006	1.537	T
				T = 0.467	T = 0.363
rs2891073	X	16499364	T/C	T = 0.368	T = 0.172	˜0.001	0.356	T
				C = 0.631	C = 0.827
rs5924599	X	16501050	C/G	C = 0.531	C = 0.535	0.920	1.013	G
				G = 0.468	G = 0.464
rs1549531	X	16506161	G/A	G = 0.719	G = 0.819	˜0.001	1.774	A
				A = 0.280	A = 0.180
rs5924601	X	16508122	A/G	A = 0.148	A = 0.153	0.813	1.047	G
				G = 0.851	G = 0.846
rs5901609	X	16510285	C/—	C = 0.269	C = 0.175	0.001	0.578	C
				— = 0.730	— = 0.824
rs5969739	X	16511416	C/T	C = 0.297	C = 0.223	0.011	0.680	C
				T = 0.702	T = 0.776
rs5924602	X	16512549	T/G	T = 0.617	T = 0.603	0.662	0.941	T
				G = 0.382	G = 0.396
rs1426798	X	16513760	A/C	A = 0.337	A = 0.257	0.008	0.681	A
				C = 0.662	C = 0.742
rs7891150	X	16514001	C/T	C = 0.986	C = 0.966	0.227	0.409	C
				T = 0.014	T = 0.034
rs4828550	X	16514202	G/A	G = 0.758	G = 0.850	˜0.001	1.820	A
				A = 0.241	A = 0.149
rs5924603	X	16515789	T/C	T = 0.319	T = 0.238	0.011	0.665	T
				C = 0.680	C = 0.761
rs1807947	X	16524486	A/G	A = 0.347	A = 0.262	0.005	0.667	A
				G = 0.652	G = 0.737
rs954253	X	16524529	A/G	A = 0.701	A = 0.685	0.601	0.927	A
				G = 0.298	G = 0.314
rs2382814	X	16525161	T/G	T = 0.327	T = 0.224	˜0.001	0.595	T
				G = 0.672	G = 0.775
rs1896178	X	16525530	A/G	A = 0.553	A = 0.520	0.324	0.873	A
				G = 0.446	G = 0.479
rs1896177	X	16525550	A/G	A = 0.499	A = 0.503	0.917	1.014	G
				G = 0.500	G = 0.496
rs5924605	X	16525704	C/G	C = 0.805	C = 0.839	0.224	1.262	G
				G = 0.194	G = 0.160
rs5924606	X	16528221	A/G	A = 0.443	A = 0.353	0.008	0.688	A
				G = 0.556	G = 0.646

TABLE 40
Males
								Melanoma
	Chromo-	Chromosome		Male	Male	F	Odds	Associated
dbSNP rs#	some	Position	Alleles	Case AF	Control AF	p-Value	Ratio	Allele
rs1904525	X	16315373	T/C	T = 0.569	T = 0.597	0.487	1.122	C
				C = 0.430	C = 0.402
rs5924557	X	16315940	C/T	C = 0.592	C = 0.591	0.975	0.996	C
				T = 0.407	T = 0.408
rs5924616	X	16315984	A/T	A = 0.495	A = 0.456	0.292	0.854	A
				T = 0.504	T = 0.543
rs5924617	X	16316317	G/A	G =	G =
				A =	A =
rs7883612	X	16316522	G/A	G = 0.559	G = 0.529	0.371	0.884	G
				A = 0.440	A = 0.470
rs5924618	X	16317598	C/T	C = 0.386	C = 0.369	0.609	0.930	C
				T = 0.613	T = 0.630
rs5924619	X	16320441	T/C	T = 0.437	T = 0.369	0.047	0.753	T
				C = 0.562	C = 0.630
AJ	X	16325687	G/T	G = 0.038	G = 0.015	0.185	0.385	G
				T = 0.962	T = 0.985
rs5901596	X	16328645	—/TGG	— = 0.351	— = 0.340	0.728	0.950	—
				TGG = 0.648	TGG = 0.659
rs7878645	X	16329011	T/C	T = 0.452	T = 0.473	0.575	1.086	C
				C = 0.547	C = 0.526
rs5924564	X	16329449	C/G	C = 0.325	C = 0.258	0.042	0.722	C
				G = 0.674	G = 0.741
rs5924535	X	16339112	A/G	A = 0.634	A = 0.633	0.997	1.000	A
				G = 0.365	G = 0.366
AK	X	16340366	A/C	A = 0.687	A = 0.705	0.605	1.088	C
				C = 0.312	C = 0.294
rs6629197	X	16348454	C/T	C = 0.760	C = 0.761	0.969	1.006	T
				T = 0.239	T = 0.238
rs7060904	X	16355981	G/T	G = 0.479	G = 0.525	0.187	1.200	T
				T = 0.520	T = 0.474
rs4828523	X	16356574	A/G	A = 0.873	A = 0.903	0.191	1.367	G
				G = 0.126	G = 0.096
rs5924568	X	16357048	C/G	C = 0.847	C = 0.885	0.117	1.390	G
				G = 0.152	G = 0.114
rs5924569	X	16357134	A/G	A = 0.324	A = 0.266	0.088	0.756	A
				G = 0.675	G = 0.733
rs1904528	X	16365163	C/T	C = 0.244	C = 0.207	0.219	0.810	C
				T = 0.755	T = 0.792
rs5924570	X	16365782	C/G	C = 0.424	C = 0.409	0.665	0.941	C
				G = 0.575	G = 0.590
rs1904527	X	16369641	A/G	A = 0.500	A = 0.470	0.468	0.888	A
				G = 0.499	G = 0.529
rs2052763	X	16370572	G/A	G = 0.278	G = 0.214	0.034	0.709	G
				A = 0.721	A = 0.785
rs1549529	X	16377566	A/G	A = 0.396	A = 0.250	˜0.001	0.510	A
				G = 0.603	G = 0.749
rs5924573	X	16379322	A/G	A = 0.479	A = 0.408	0.057	0.751	A
				G = 0.520	G = 0.591
rs5901600	X	16384421	—/T	— = 0.831	— = 0.863	0.211	1.283	T
				— = 0.867	— = 0.890
rs5901600	X	16384421	—/T	T = 0.168	T = 0.136	0.211	1.283	T
				T = 0.132	T = 0.109
rs2288304	X	16385394	T/C	T = 0.676	T = 0.689	0.726	1.062	C
				C = 0.323	C = 0.310
rs4240072	X	16386837	A/G	A = 0.305	A = 0.227	0.018	0.668	A
				G = 0.694	G = 0.772
rs3055191	X	16388721	—/	— = 0.497	— = 0.479	0.621	0.933	—
				= 0.502	= 0.520
rs6632943	X	16393300	T/C	T = 0.504	T = 0.503	0.967	0.994	T
				C = 0.495	C = 0.496
rs5924580	X	16395181	G/A	G = 0.811	G = 0.775	0.264	0.803	G
				A = 0.188	A = 0.224
rs4828544	X	16398058	T/C	T = 0.797	T = 0.852	0.039	1.464	C
				C = 0.202	C = 0.147
rs1807412	X	16400368	A/G	A = 0.582	A = 0.629	0.202	1.214	G
				G = 0.417	G = 0.370
rs2010456	X	16400419	G/A	G = 0.023	G = 0.026	0.799	1.154	A
				A = 0.976	A = 0.973
rs5969758	X	16402566	G/A	G = 0.238	G = 0.200	0.193	0.801	G
				A = 0.761	A = 0.799
rs1965051	X	16404435	A/G	A = 0.305	A = 0.239	0.036	0.716	A
				G = 0.694	G = 0.760
rs9887218	X	16404794	T/C	T = 0.040	T = 0.038	0.946	0.959	T
				C = 0.959	C = 0.961
rs1426800	X	16407797	G/A	G = 0.798	G = 0.871	0.005	1.711	A
				A = 0.201	A = 0.128
rs5969759	X	16417444	A/G	A = 0.621	A = 0.672	0.165	1.252	G
				G = 0.378	G = 0.327
rs6527766	X	16418221	T/C	T = 0.787	T = 0.799	0.704	1.073	C
				C = 0.212	C = 0.200
rs1365529	X	16421764	T/C	T = 0.836	T = 0.874	0.131	1.359	C
				C = 0.163	C = 0.125
rs5924582	X	16422381	G/A	G = 0.780	G = 0.797	0.542	1.109	A
				A = 0.219	A = 0.202
rs2114458	X	16424226	G/A	G = 0.814	G = 0.838	0.381	1.186	A
				A = 0.185	A = 0.161
rs5924583	X	16424670	T/C	T = 0.715	T = 0.726	0.711	1.059	C
				C = 0.284	C = 0.273
rs5924545	X	16426360	G/A	G = 0.822	G = 0.860	0.141	1.333	A
				A = 0.177	A = 0.139
rs5969761	X	16429055	C/T	C = 0.811	C = 0.899	0.001	2.076	T
				T = 0.188	T = 0.100
rs6629201	X	16429589	C/T	C = 0.609	C = 0.632	0.486	1.103	T
				T = 0.390	T = 0.367
rs6629202	X	16429694	C/T	C = 0.733	C = 0.785	0.151	1.328	T
				T = 0.266	T = 0.214
rs5924584	X	16430036	A/G	A = 0.826	A = 0.878	0.039	1.517	G
				G = 0.173	G = 0.121
rs5924585	X	16430411	A/G	A = 0.851	A = 0.851	0.997	0.999
				G = 0.148	G = 0.148
rs933946	X	16432114	T/C	T = 0.834	T = 0.855	0.434	1.173	C
				C = 0.165	C = 0.144
AL	X	16434518	C/T	C = 0.765	C = 0.779	0.673	1.078	T
				T = 0.234	T = 0.220
rs5969762	X	16437465	A/G	A = 0.599	A = 0.564	0.308	0.866	A
				G = 0.400	G = 0.435
rs713355	X	16441918	T/C	T = 0.521	T = 0.542	0.551	1.086	C
				C = 0.478	C = 0.457
rs1365530	X	16442441	G/C	G = 0.816	G = 0.874	0.024	1.577	C
				C = 0.183	C = 0.125
rs1961490	X	16442515	A/T	A = 0.711	A = 0.723	0.701	1.061	T
				T = 0.288	T = 0.276
rs6527769	X	16444016	C/G	C = 0.353	C = 0.290	0.073	0.746	C
				G = 0.646	G = 0.709
rs2006847	X	16448321	A/G	A = 0.514	A = 0.544	0.410	1.128	G
				G = 0.485	G = 0.455
rs2382813	X	16451525	A/G	A = 0.893	A = 0.912	0.379	1.238	G
				G = 0.106	G = 0.087
rs2033120	X	16451681	C/G	C = 0.810	C = 0.851	0.161	1.338	G
				G = 0.189	G = 0.148
rs2162394	X	16452045	A/G	A = 0.295	A = 0.238	0.064	0.744	A
				G = 0.704	G = 0.761
rs1346246	X	16453578	C/A	C = 0.383	C = 0.312	0.031	0.729	C
				A = 0.616	A = 0.687
rs1365527	X	16454202	G/C	G = 0.830	G = 0.864	0.185	1.303	C
				C = 0.169	C = 0.135
rs1426801	X	16454405	T/C	T = 0.450	T = 0.461	0.791	1.043	C
				C = 0.549	C = 0.538
rs5924546	X	16455761	G/C	G = 0.419	G = 0.419	0.994	1.001
				C = 0.580	C = 0.580
rs5924547	X	16457294	G/C	G = 0.523	G = 0.551	0.437	1.115	C
				C = 0.476	C = 0.448
rs1365528	X	16459880	G/A	G = 0.206	G = 0.180	0.381	0.848	G
				A = 0.793	A = 0.819
rs4828524	X	16462614	A/G	A = 0.271	A = 0.211	0.049	0.719	A
				G = 0.728	G = 0.788
rs5924588	X	16463585	C/T	C = 0.713	C = 0.785	0.026	1.469	T
				T = 0.286	T = 0.214
rs5969764	X	16469155	C/T	C = 0.817	C = 0.877	0.066	1.605	T
				T = 0.182	T = 0.122
rs5924589	X	16473218	T/G	T = 0.319	T = 0.267	0.104	0.778	T
				G = 0.680	G = 0.732
rs5924590	X	16475436	G/T	G = 0.831	G = 0.871	0.121	1.369	T
				T = 0.168	T = 0.128
rs5924591	X	16478928	G/T	G = 0.850	G = 0.885	0.166	1.361	T
				T = 0.149	T = 0.114
rs5924592	X	16480847	A/G	A = 0.416	A = 0.413	0.938	0.989	A
				G = 0.583	G = 0.586
rs5924548	X	16480891	G/A	G = 0.697	G = 0.707	0.774	1.045	A
				A = 0.302	A = 0.292
rs5924593	X	16480935	C/G	C = 0.716	C = 0.815	0.010	1.744	G
				G = 0.283	G = 0.184
rs4828547	X	16482661	A/G	A = 0.810	A = 0.847	0.162	1.300	G
				G = 0.189	G = 0.152
rs714070	X	16483528	A/G	A = 0.525	A = 0.550	0.490	1.104	G
				G = 0.474	G = 0.449
rs5969768	X	16490615	T/C	T = 0.054	T = 0.166	˜0.001	3.445	C
				C = 0.945	C = 0.833
rs4828526	X	16491635	G/A	G = 0.211	G = 0.174	0.223	0.791	G
				A = 0.788	A = 0.825
rs5969738	X	16492763	G/A	G = 0.492	G = 0.545	0.136	1.237	A
				A = 0.507	A = 0.454
rs5924595	X	16493358	G/A	G = 0.782	G = 0.842	0.038	1.487	A
				A = 0.217	A = 0.157
rs5924549	X	16493425	A/G	A = 0.727	A = 0.774	0.129	1.287	G
				G = 0.272	G = 0.225
rs4828528	X	16494704	T/C	T = 0.182	T = 0.179	0.921	0.980	T
				C = 0.817	C = 0.820
rs5969769	X	16495532	G/A	G = 0.823	G = 0.874	0.061	1.494	A
				A = 0.176	A = 0.125
rs4007744	X	16497657	C/T	C = 0.597	C = 0.644	0.252	1.221	T
				T = 0.402	T = 0.355
rs2891073	X	16499364	T/C	T = 0.256	T = 0.099	˜0.001	0.321	T
				C = 0.743	C = 0.900
rs5924599	X	16501050	C/G	C = 0.479	C = 0.554	0.033	1.347	G
				G = 0.520	G = 0.445
rs1549531	X	16506161	G/A	G = 0.748	G = 0.821	0.010	1.547	A
				A = 0.251	A = 0.178
rs5924601	X	16508122	A/G	A = 0.132	A = 0.231	˜0.001	1.975	G
				G = 0.867	G = 0.768
rs5901609	X	16510285	C/—	C = 0.253	C = 0.190	0.032	0.689	C
				— = 0.746	— = 0.809
rs5969739	X	16511416	C/T	C = 0.278	C = 0.246	0.293	0.846	C
				T = 0.721	T = 0.753
rs5924602	X	16512549	T/G	T = 0.666	T = 0.588	0.020	0.716	T
				G = 0.333	G = 0.411
rs1426798	X	16513760	A/C	A = 0.336	A = 0.270	0.040	0.729	A
				C = 0.663	C = 0.729
rs7891150	X	16514001	C/T	C = 0.979	C = 0.970	0.622	0.674	C
				T = 0.020	T = 0.029
rs4828550	X	16514202	G/A	G = 0.763	G = 0.848	0.004	1.730	A
				A = 0.236	A = 0.151
rs5924603	X	16515789	T/C	T = 0.314	T = 0.241	0.019	0.692	T
				C = 0.685	C = 0.758
rs1807947	X	16524486	A/G	A = 0.340	A = 0.260	0.013	0.681	A
				G = 0.659	G = 0.739
rs954253	X	16524529	A/G	A = 0.659	A = 0.681	0.514	1.101	G
				G = 0.340	G = 0.318
rs2382814	X	16525161	T/G	T = 0.293	T = 0.231	0.059	0.726	T
				G = 0.706	G = 0.768
rs1896178	X	16525530	A/G	A = 0.541	A = 0.511	0.404	0.887	A
				G = 0.458	G = 0.488
rs1896177	X	16525550	A/G	A = 0.498	A = 0.501	0.931	1.012	G
				G = 0.501	G = 0.498
rs5924605	X	16525704	C/G	C = 0.802	C = 0.839	0.214	1.289	G
				G = 0.197	G = 0.160
rs5924606	X	16528221	A/G	A = 0.419	A = 0.340	0.025	0.713	A
				G = 0.580	G = 0.659

Allelotyping results were considered significant with a calculated p-value of less than or equal to 0.05 for allelotype results. These values are indicated in bold. The assay failed for those SNPs in which the allele frequency is blank. The combined allelotyping p-values for males and females were plotted in FIG. 6A and separately for females and males in FIGS. 6B and 6C, respectively. The position of each SNP on the chromosome is presented on the x-axis. The y-axis gives the negative logarithm (base 10) of the p-value comparing the estimated allele frequency in the case group to that of the control group. The minor allele frequency of the control group for each SNP designated by an X or other symbol on the graphs in FIGS. 6A, 6B and 6C can be determined by consulting Table 39 or 40. By proceeding down the Table from top to bottom and across the graphs from left to right the allele frequency associated with each symbol shown can be determined.

To aid the interpretation, multiple lines have been added to the graph. The broken horizontal lines are drawn at two common significance levels, 0.05 and 0.01. The vertical broken lines are drawn every 20 kb to assist in the interpretation of distances between SNPs. Two other lines are drawn to expose linear trends in the association of SNPs to the disease. The light gray line (or generally bottom-most curve) is a nonlinear smoother through the data points on the graph using a local polynomial regression method (W. S. Cleveland, E. Grosse and W. M. Shyu (1992) Local regression models. Chapter 8 of Statistical Models in S eds J. M. Chambers and T. J. Hastie, Wadsworth & Brooks/Cole.). The black line (or generally top-most curve, e.g., see peak in left-most graph just to the left of position 92150000) provides a local test for excess statistical significance to identify regions of association. This was created by use of a 1 Okb sliding window with 1 kb step sizes. Within each window, a chi-square goodness of fit test was applied to compare the proportion of SNPs that were significant at a test wise level of 0.01, to the proportion that would be expected by chance alone (0.05 for the methods used here). Resulting p-values that were less than 10⁻⁸ were truncated at that value.

Finally, the exons and introns of the genes in the covered region are plotted below each graph at the appropriate chromosomal positions. The gene boundary is indicated by the broken horizontal line. The exon positions are shown as thick, unbroken bars. An arrow is place at the 3′ end of each gene to show the direction of transcription.

Example 11

Inhibition of NRP1 Gene Expression by Transfection of Specific siRNAs

RNAi-based gene inhibition was selected as an effective way to inhibit expression of NRP1 in cultured cells. Algorithms useful for designing siRNA molecules specific for the NRP1 targets are disclosed at the http address www.dhramacon.com. siRNAs were selected from this list for use in RNAi experiments following a filtering protocol that involved the removal of any siRNA with complementarity to common motifs or domains present in any target as well as siRNAs complementary to sequences containing SNPs. From this filtered set of siRNAs, four were selected that showed no off-target homology following BLAST analysis against various Genbank nucleotide databases. Table 41 summarize the features of the duplexes that were ordered from Dharmacon Research, Inc., and subsequently used as a cocktail in the assays described herein to inhibit expression of NRP1, NID2 ENDO180, CDK10, FPGT, CARK, PCLO or REPS2, respectively. A non-homologous siRNA reagent was used as a negative control.

TABLE 41
NRP1 siRNAs used for cell transfection
	siRNA		SEQ ID
siRNA	Target	Sequence Specificity	NO:
NRP1_425	NRP1	AGAGAGGTCCTGAATGTTC
NRP1_1282	NRP1	GATTATCCTTGCTCTGGAA
NRP1_1910	NRP1	GCACCATACAATCAGAGTT
NRP1_2538	NRP1	GCCAGGCAATGTGTTGAAG

Two melanoma cell lines (M14 and A375) and a breast cancer cell line (MCF7) were selected for RNAi experiments. On day 1, cells were transfected with siRNA cocktails (18.75 nM) using LIPOFECTAMINE 2000 (LF2000™) Reagent. On days 1, 3 and 6, cellular proliferation was measured using the WST-1 assay (Roche, catalog #1644807). Briefly, the WST-1 assay is a colorimetric assay used to determine cellular proliferation by measuring the cleavage of WST-1 by mitochondrial dehydrogenases in living cells. By measuring absorbance, a highly accurate measure of cellular proliferation is obtained. On day 1, WST-1 reagent was added to each well and allowed to incubate for 3-4 hours. Subsequently, absorbance was measured at 450 nm and 620 nm using a Tecan Ultra plate reader. This process was repeated on day's 3 and 6. The extent of proliferation on days 3 and 6 were calculated relative to day 1, based on absorbance readings for each sample on each day. From the triplicate repeats of each time point, means and standard deviations were calculated and the effect of siRNA inhibition of each target on cellular proliferation was assessed and compared to cells transfected with a positive control siRNA (siRAD21_—1175) and a negative control siRNA (siLuciferase GL2). All experiments were performed in duplicate.

The difference in absorbance between these 2 wavelengths is an indication of the metabolic activity in each well that was measured. Metabolic activity is directly proportional to the number of cells in each well. Suppression of target mRNA levels correlated with decreased cell proliferation. The NRP1 siRNA suppressed proliferation of melanoma M14 cells and A375 cell (see FIGS. 7A and 7B respectively).

Example 12

Inhibition of CDK10 Gene Expression by Transfection of Specific siRNAs

RNAi-based gene inhibition was selected as an effective way to inhibit expression of CDK10 in cultured cells. Algorithms useful for designing siRNA molecules specific for the CDK10 targets are disclosed at the http address www.dhramacon.com. siRNAs were selected from this list for use in RNAi experiments following a filtering protocol that involved the removal of any siRNA with complementarity to common motifs or domains present in any target as well as siRNAs complementary to sequences containing SNPs. From this filtered set of siRNAs, four were selected that showed no off-target homology following BLAST analysis against various Genbank nucleotide databases. Table 42 summarizes the features of the duplexes that were ordered from Dharmacon Research, Inc., and subsequently used as a cocktail in the assays described herein to inhibit expression of CDK10. A non-homologous siRNA reagent was used as a negative control.

TABLE 42
CDK10 siRNAs used for cell transfection
	siRNA
siRNA	Target	Sequence Specificity	SEQ ID NO:
CDK10_59	CDK10	GATCCGTCTGAAGTGTATT
CDK10_149	CDK10	GAAGCTGAACCGCATTGGA
CDK10_175	CDK10	CCTACGGCATTGTGTATCG
CDK10_532	CDK10	ACTTGCTCATGACCGACAA

Two melanoma cell lines (M14 and A375) were selected for RNAi experiments. On day 1, cells were transfected with siRNA cocktails (18.75 nM) using LIPOFECTAMINE 2000 (LF2000™) Reagent. On days 1, 3 & 6, cellular proliferation was measured using the WST-1 assay (Roche, catalog #1 644 807). Briefly, the WST-1 assay is a colorimetric assay used to determine cellular proliferation by measuring the cleavage of WST-1 by mitochondrial dehydrogenases in living cells. By measuring absorbance, a highly accurate measure of cellular proliferation is obtained. On day 1, WST-1 reagent was added to each well and allowed to incubate for 3-4 h. Subsequently, absorbance was measured at 450 nm and 620 nm using a Tecan Ultra plate reader. This process was repeated on day's 3 and 6. The extent of proliferation on days 3 and 6 were calculated relative to day 1, based on absorbance readings for each sample on each day. From the triplicate repeats of each time point, means and standard deviations were calculated and the effect of siRNA inhibition of each target on cellular proliferation was assessed and compared to cells transfected with a positive control siRNA (siRAD21_—1175) and a negative control siRNA (siLuciferase GL2). All experiments were performed in duplicate.

Example 13

Cell Proliferation

The siRNAs from Example 12 were transfected in cell lines grown in 6-well plates. Cells were trypsinized on the following day and distributed into 96-well plates. Wst-1 reagent was added on the indicated days and the absorbance at 650 nm and 450 nm was measured. The difference in absorbance between these 2 wavelengths is an indication of the metabolic activity in each well that was measured. Metabolic activity is directly proportional to the number of cells in each well.

Suppression of target mRNA levels correlated with decreased cell proliferation as seen in A375 melanoma cells (see FIG. 8).

Example 14

Screening Assay to Detect Modulators of NRP1

The following is an exemplary assay for finding modulators of NRP1. Plasma membranes are prepared from cells expressing NRP1 by standard methods. The membranes are immobilized on wheat germ agglutinin-coated scintillation proximity beads (Amersham). Test samples and radiolabeled ligand, which is ¹²⁵I-semaphorin-3, are added, and bead-bound radioactivity is measured. The ability of a given sample to modulate binding activity is determined by comparison of bead-bound radioactivity in the presence of the compound with values obtained in solvent controls. The test compound optimally produces a result that differs by at least 3 standard deviations from a set of at least 30 replicate control samples.

Example 15

Screening Assay to Detect Modulators of NID2

The following is an exemplary assay for finding modulators of NID2. Plasma membranes as prepared are prepared from cells expressing integrin alpha-3-beta-1 or integrin alpha-6-beta-1 by standard methods. The membranes are immobilized on wheat germ agglutinin-coated scintillation proximity beads (Amersham). Test sample and radiolabeled ligand, which is ¹²⁵I-NID2, are added, and bead-bound radioactivity is measured. The ability of a given sample to modulate binding activity is determined by comparison of bead-bound radioactivity in the presence of the compound with values obtained in solvent controls. The test compound optimally produces a result that differs by at least 3 standard deviations from a set of at least 30 replicate control samples.

Example 16

Screening Assay to Detect Modulators of ENDO180

The following is an exemplary assay for finding modulators of ENDO180. Plasma membranes are prepared from cells expressing ENDO180 by standard methods. The membranes are immobilized on wheat germ agglutinin-coated scintillation proximity beads (Amersham). Test sample and radiolabeled ligand, which is ³H-mannose are added and bead-bound radioactivity is measured. The ability of a given sample to modulate binding activity is determined by comparison of bead-bound radioactivity in the presence of the compound with values obtained in solvent controls. The test compound optimally produces a result that differs by at least 3 standard deviations from a set of at least 30 replicate control samples.

Example 17

Screening Assay to Detect Modulators of CDK10

The following is an exemplary assay for finding modulators of CDK10. CDK10 may be screened using, for example, the non-radioactive IMAP system available from Molecular Devices, Sunnyvale Calif. 94089, according to the manufacturers instructions. The ability of a given compound to modulate activity of the kinase is determined by comparison of fluorescence polarization values in the IMAP assay in the presence of the compound with values obtained in solvent controls. Preferably, the test compound should produce a result that differs by at least 3 standard deviations from a set of at least 30 replicate control samples. More specifically, IMAP is a technology that uses the specific binding of metal (M III) coordination complexes to phosphate groups at high salt concentration and a fluorescence polarization readout. In a microwell assay format, fluorescently labeled peptides are phosphorylated in a kinase reaction. After the reaction, proprietary IMAP nanoparticles derivatized with metal (M^III) coordination complexes are added to the assay to bind the phosphorylated peptides. The binding causes a change in the motion of the peptide, and results in an increase in the observed fluorescence polarization. This assay, unlike antibody-based homogeneous kinase assays, is applicable to a wide variety of tyrosine and serine/threonine kinases. IMAP technology is largely independent of the sequence of the substrate peptides. In addition, the technology is useful in assays of phosphodiesterases and phosphatases. In a typical reaction on a 384-well plate the following would be combined: 10 ul of the kinase in question, 5 ul of test compound, 5 ul of substrate, such as Myelin Basic Protein Fragment 4-14 (MDL Number MFCD00133371; CAS Number 126768-94-3) or a similarly-sized peptide, at a concentration of 30-1000 nM; and ATP at a concentration of 1-30 ul. The substrate may be labeled with a fluorophore such as fluorescein-5-isothiocyanate (FITC Isomer I). These reagents would be allowed to react at room temperature for one hour. Then 60 ul of IMAP binding reagent is added and the fluorescence polarization is read.

Example 18

Screening Assay to Detect Modulators of TNNI3K (CARK)

The following is an exemplary assay for finding modulators of TNNI3K (CARK). TNNI3K (CARK) may be screened using, for example, the non-radioactive IMAP system available from Molecular Devices, Sunnyvale Calif. 94089, according to the manufacturers instructions. The ability of a given compound to modulate activity of the kinase is determined by comparison of fluorescence polarization values in the IMAP assay in the presence of the compound with values obtained in solvent controls. Preferably, the test compound should produce a result that differs by at least 3 standard deviations from a set of at least 30 replicate control samples. More specifically, IMAP is a technology that uses the specific binding of metal (M^III) coordination complexes to phosphate groups at high salt concentration and a fluorescence polarization readout. In a microwell assay format, fluorescently labeled peptides are phosphorylated in a kinase reaction. After the reaction, proprietary IMAP nanoparticles derivatized with metal (M^III) coordination complexes are added to the assay to bind the phosphorylated peptides. The binding causes a change in the motion of the peptide, and results in an increase in the observed fluorescence polarization. This assay, unlike antibody-based homogeneous kinase assays, is applicable to a wide variety of tyrosine and serine/threonine kinases. IMAP technology is largely independent of the sequence of the substrate peptides. In addition, the technology is useful in assays of phosphodiesterases and phosphatases. In a typical reaction on a 384-well plate the following would be combined: 10 ul of the kinase in question, 5 ul of test compound, 5 ul of substrate, such as Myelin Basic Protein Fragment 4-14 (MDL Number MFCD00133371; CAS Number 126768-94-3) or a similarly-sized peptide, at a concentration of 30-1000 nM; and ATP at a concentration of 1-30 ul. The substrate may be labeled with a fluorophore such as fluorescein-5-isothiocyanate (FITC Isomer I). These reagents would be allowed to react at room temperature for one hour. Then 60 ul of IMAP binding reagent is added and the fluorescence polarization is read.

Example 19

Screening Assay to Detect Modulators of FPGT

The following is an exemplary assay for finding modulators of FPGT. Incubate enzyme plus test sample plus substrates (fucose-1-phosphate and alpha-33P GTP (Amersham)) under conditions described (Pastuszak, I., Ketchum, C., Hermanson, G., Sjoberg, E. J., Drake, R. and Elbein, A. D. GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme J. Biol. Chem. 273 (46), 30165-30174 (1998)). Add to the reaction mixture streptavidin coated scintillation proximity beads (Amersham) precoated with biotinylated lotus lectin (Vector Labs, Burlingame Calif. 94010). Measure bead-associated radioactivity by scintillation counting. The ability of a given compound to modulate activity of the enzyme is determined by comparison of bead-bound radioactivity in the presence of the compound with values obtained in solvent controls. Preferably, the test compound should produce a result that differs by at least 3 standard deviations from a set of at least 30 replicate control samples.

Example 20

In Vitro Production of Target Polypeptides

Target polypeptides encoded by the polynucleotides described herein may be produced by the methods described hereafter. cDNA is cloned into a pIVEX 2.3-MCS vector (Roche Biochem) using a directional cloning method. A cDNA insert is prepared using PCR with forward and reverse primers having 5′ restriction site tags (in frame) and 5-6 additional nucleotides in addition to 3′ gene-specific portions, the latter of which is typically about twenty to about twenty-five base pairs in length. A Sal I restriction site is introduced by the forward primer and a Sma I restriction site is introduced by the reverse primer. The ends of PCR products are cut with the corresponding restriction enzymes (i.e., Sal I and Sma I) and the products are gel-purified. The pIVEX 2.3-MCS vector is linearized using the same restriction enzymes, and the fragment with the correct sized fragment is isolated by gel-purification. Purified PCR product is ligated into the linearized pIVEX 2.3-MCS vector and E. coli cells transformed for plasmid amplification. The newly constructed expression vector is verified by restriction mapping and used for protein production.

E. coli lysate is reconstituted with 0.25 ml of Reconstitution Buffer, the Reaction Mix is reconstituted with 0.8 ml of Reconstitution Buffer; the Feeding Mix is reconstituted with 10.5 ml of Reconstitution Buffer; and the Energy Mix is reconstituted with 0.6 ml of Reconstitution Buffer. 0.5 ml of the Energy Mix was added to the Feeding Mix to obtain the Feeding Solution. 0.75 ml of Reaction Mix, 50 μl of Energy Mix, and 10 μg of the template DNA is added to the E. coli lysate.

Using the reaction device (Roche Biochem), 1 ml of the Reaction Solution is loaded into the reaction compartment. The reaction device is turned upside-down and 10 ml of the Feeding Solution is loaded into the feeding compartment. All lids are closed and the reaction device is loaded into the RTS500 instrument. The instrument is run at 30° C. for 24 hours with a stir bar speed of 150 rpm. The pIVEX 2.3 MCS vector includes a nucleotide sequence that encodes six consecutive histidine amino acids on the C-terminal end of the target polypeptide for the purpose of protein purification. target polypeptide is purified by contacting the contents of reaction device with resin modified with Ni²⁺ ions. target polypeptide is eluted from the resin with a solution containing free Ni²⁺ ions.

Example 21

Cellular Production of Target Polypeptides

Nucleic acids are cloned into DNA plasmids having phage recombination cites and target polypeptides are expressed therefrom in a variety of host cells. Alpha phage genomic DNA contains short sequences known as attP sites, and E. coli genomic DNA contains unique, short sequences known as attB sites. These regions share homology, allowing for integration of phage DNA into E. coli via directional, site-specific recombination using the phage protein Int and the E. coli protein IHF. Integration produces two new att sites, L and R, which flank the inserted prophage DNA. Phage excision from E. coli genomic DNA can also be accomplished using these two proteins with the addition of a second phage protein, Xis. DNA vectors have been produced where the integration/excision process is modified to allow for the directional integration or excision of a target DNA fragment into a backbone vector in a rapid in vitro reaction (Gateway™ Technology (Invitrogen, Inc.)).

A first step is to transfer the nucleic acid insert into a shuttle vector that contains attL sites surrounding the negative selection gene, ccdB (e.g. pENTER vector, Invitrogen, Inc.). This transfer process is accomplished by digesting the nucleic acid from a DNA vector used for sequencing, and to ligate it into the multicloning site of the shuttle vector, which will place it between the two attL sites while removing the negative selection gene ccdB. A second method is to amplify the nucleic acid by the polymerase chain reaction (PCR) with primers containing attB sites. The amplified fragment then is integrated into the shuttle vector using Int and IHF. A third method is to utilize a topoisomerase-mediated process, in which the nucleic acid is amplified via PCR using gene-specific primers with the 5′ upstream primer containing an additional CACC sequence (e.g., TOPO® expression kit (Invitrogen, Inc.)). In conjunction with Topoisomerase I, the PCR amplified fragment can be cloned into the shuttle vector via the attL sites in the correct orientation.

Once the nucleic acid is transferred into the shuttle vector, it can be cloned into an expression vector having attR sites. Several vectors containing attR sites for expression of target polypeptide as a native polypeptide, N-fusion polypeptide, and C-fusion polypeptides are commercially available (e.g., pDEST (Invitrogen, Inc.)), and any vector can be converted into an expression vector for receiving a nucleic acid from the shuttle vector by introducing an insert having an attR site flanked by an antibiotic resistant gene for selection using the standard methods described above. Transfer of the nucleic acid from the shuttle vector is accomplished by directional recombination using Int, IHF, and Xis (LR clonase). Then the desired sequence can be transferred to an expression vector by carrying out a one hour incubation at room temperature with Int, IHF, and Xis, a ten minute incubation at 37° C. with proteinase K, transforming bacteria and allowing expression for one hour, and then plating on selective media. Generally, 90% cloning efficiency is achieved by this method. Examples of expression vectors are pDEST 14 bacterial expression vector with att7 promoter, pDEST 15 bacterial expression vector with a T7 promoter and a N-terminal GST tag, pDEST 17 bacterial vector with a T7 promoter and a N-terminal polyhistidine affinity tag, and pDEST 12.2 mammalian expression vector with a CMV promoter and neo resistance gene. These expression vectors or others like them are transformed or transfected into cells for expression of the target polypeptide or polypeptide variants. These expression vectors are often transfected, for example, into murine-transformed cell lines (e.g. adipocyte cell line 3T3-L1 (ATCC), human embryonic kidney cell line 293, and rat cardiomyocyte cell line H9C2).

Provided hereafter are NRP1, NID2, ENDO180, CDK10, FPGT, PCLO and REPS2 genomic sequences (SEQ ID NO: 1, 2, 3, 4, 5, 6 and 7, respectively). Polymorphic variants are designated in IUPAC format. The following nucleotide representations are used throughout the specification and figures: “A” or “a” is adenosine, adenine, or adenylic acid; “C” or “c” is cytidine, cytosine, or cytidylic acid; “G” or “g” is guanosine, guanine, or guanylic acid; “T” or “t” is thymidine, thymine, or thymidylic acid; and “I” or “i” is inosine, hypoxanthine, or inosinic acid. SNPs are designated by the following convention: “R” represents A or G, “M” represents A or C; “W” represents A or T; “Y” represents C or T; “S” represents C or G; “K” represents G or T; “V” represents A, C or G; “H” represents A, C, or T; “D” represents A, G, or T; “B” represents C, G, or T; and “N” represents A, G, C, or T.

Following is a NRP1 genomic nucleotide sequence (SEQ ID NO: 1).

>10:33587901-33809500
1	gcaatgggtc	tcaagcaaag	cattcttcaa	gtgccccaca	gttatcaaat	aatttaaaaa
61	tcttagattt	tcatttttgt	gattatcttc	taaaaatggc	agttataccc	attgtggagc
121	acctagacag	gtaccatata	aggagtactg	ccatgtcttt	ttgtagcaac	acatatgttt
181	gtgttgatga	ttgaatgact	gccaagtgcg	gtgataggaa	agcatgaatc	cctataYagc
241	caaggttttc	cagttgttca	aaaataaaac	agtggtggga	gaggtgagcc	atcacttggg
301	aacacaggag	taacatggat	ctgaactcga	aagaccccgc	atcctggcct	ttggcagcat
361	gttcaagtct	gtggacaatt	gataagcaac	agttcattcg	tggtcagtct	agacataaat
421	aggcagtgaa	gaactttcca	ttagaagatt	ttcttcccag	accaggtgca	gtggctcacg
481	cctgtaatct	cagcattttg	ggaggctgag	gtgggaggac	tgcttgagta	caggagttcc
541	agaccagcct	gggcaaaaga	gccagatcct	gtctctacaa	aacaattttt	aagttagtca
601	ggcatggtgg	tgcacacctg	tagtcccagc	tacttgggag	gctgaggtgt	gaggatcact
661	tgagcccagg	aggttgaggc	tgcagtgagc	catgatcata	tcactgcact	cagtgtgggc
721	aataaagtga	aacccagtct	caaaaaaaca	aaagattttt	ctccctgtat	tatattttgg
781	gggtacacca	ttagatcatt	tggcctgtta	gtagataaaa	caaattaaaa	gataaaaagc
841	aaatacataa	aaataaacag	caaaggcaat	aatgatggct	aaaagggctg	cctattatgc
901	taaaactcaa	ggaaattaag	ttaataacaa	gcaaagccta	aagtgcaagt	acgttctact
961	agtatattac	ccaataacag	gaattttgct	tctacaaaat	gccatcagtc	atcacaccaa
1021	attaatgttg	tcatctgagt	gtttgggttt	tgtagttatg	ttgggattag	tgtgtaaagt
1081	tgcttggact	catttgttgt	atgggaatac	taagggtaaa	aaaatgtgtg	agtgaatttt
1141	ttgtaggtat	ataataagat	tagaataaaa	gagtgatctt	caacaccaaa	gatccttgga
1201	aatgtttccc	tttaaaagag	ggtcatacat	tccttaagtt	ggggaaatac	tgtgttttct
1261	ttcagctcca	tcctcgggcc	tttcagtgag	gacaggaacc	cacggccaga	caggaaggcc
1321	tgtttgaagc	caggttgcct	ccctagtaag	tttgttctgg	agccttctgg	tctccttttc
1381	ttttagttac	tttaagtggt	tttaggaaaa	agtactcttt	tcatcttaat	cctgctcctt
1441	acacccaagc	cagcccagag	ccatctggaa	tcctcagaac	agacctattc	tttgaagaga
1501	agaaggacaa	gatgtttttg	gacccttgca	ggaggtctgg	atacagacgg	ggccctgggg
1561	agggttgatc	cccagcagta	actgctcagc	tggaggcatg	aggggtccct	tctgacctcc
1621	aagcttcaga	ggggatggga	aaaggtaatt	tggcagcttt	gtgttccaag	gcttcacccc
1681	tagattggtt	taggcaagag	tcagtgagtc	cctgggaagg	cactgggcca	gcagagccca
1741	gacatcaagg	ctagcatttc	agtcttaata	atccaattta	ggctgggcgt	ggttgctcat
1801	gcctgtaatc	ccagcaattt	gggaggctga	ggcagatgga	tcatctgagg	ccaggagttc
1861	aagaccagta	tggccaacat	ggcgaaaccc	cgcctctact	aaaaatacaa	aaattagccg
1921	agcatggtgg	tgcatgcctg	tagtcccagc	tacttgagag	gcttaagcag	gagaatcact
1981	tgaacccagg	aggcggagtt	tgcagtcagc	caagatcgtg	ccaaaagaaa	aaaaaaagaa
2041	taaaaaacca	atttaaacaa	agaaaaacct	ttcattgagc	tctttaaata	tcctaagaat
2101	tgattataaa	tcacaaattg	gaagccaaca	taagctgtaa	Ygcaaagcaa	gcactgaaca
2161	tctctctacc	tgatgccact	taagttatgg	taaatttagt	caaggctgtg	ggttggggtt
2221	gtgtgcctta	ttgcaggaag	cagcacactt	ctgagggata	aatattgcat	ttggaaccta
2281	tgagttggta	gtttttctcc	aaggatgttc	ttaaaagcca	tttgcaatga	atttgtcagt
2341	ttctttagat	ttggatggaa	tataacgatt	ctggaacatt	actggggcct	ctgaaaattg
2401	tatttcctac	cttatatctt	acgtggctaa	agtacatggc	tgggagcggt	ggctcacgcc
2461	tctcatccca	gcaatttggg	aagccaaggt	gggtggatca	cctgaagtca	ggagtccaag
2521	accagcctgg	ccaacatggt	gaaaccctgt	ccctactaaa	aatacaaaaa	ttagctgggt
2581	ttggtggcat	gtgcctgtag	tcccagtcta	cttggaaggc	tgaggcagga	gaattgcttg
2641	aacccaggag	gcagaggttg	cagtgagctg	agactgtgcc	actgcactcc	agtctgggag
2701	acagagcgag	actttgtctc	aaaaaaaaaa	aaaaaaaaaa	agtacatctt	gttccaagaa
2761	acctactttt	ccttcaaaca	ctttgaggtt	taaaggcagg	atttactacc	ctctgtcctg
2821	acggcagagg	gagaaggagg	agaggaagga	acagaggctg	tcaccccttg	atgattttct
2881	gggatcctac	agttagatgg	gggtatggtc	tcctgcccta	tgaaaaccag	attctaggat
2941	gctattctaa	gaaaaaaaaa	Ntcccctgga	atcatattat	cttctgaaaa	ctagtgccac
3001	attttcctgt	tgatactata	ctcatcaact	tcagttcaca	gtcaaaattc	agttatcctg
3061	ttaatcttgc	tcattttggc	aggcacgaaa	atacacatgt	ttgtatggag	ccaagcaagt
3121	ttttgagatc	ttgggatcct	ctggaaatat	tttttcagtt	gttgaaaagg	aacttgcaag
3181	aaagcatata	ttttcaacac	tcgtcccagg	aacagtgtgt	gaaagtgaca	ttaaacttat
3241	ttctacactg	ggtgactagt	gactccctgc	tgggtaatca	ggtagacctc	tgtcatctct
3301	gcttcactgg	ggtttactgc	cagggcgtag	agagtctcat	ctcatggatc	ggaagaatgg
3361	gctgtacaca	cagacagctc	tcaccctcct	gttctggcgc	tgggctattc	ttcacggcca
3421	ctctttacac	tgagaaacac	ctcatgaatt	ttcagcctgg	aagacgatgg	gcccatttaa
3481	tgttctaacc	atatagagtg	cctgaattcc	caagatctcc	aactgctttt	cacttactac
3541	cctggaaaga	accccagtag	catccgttat	gaagacaaga	actccgcaaa	tctcctcctt
3601	gctggctggg	gagcaggagg	tctcataatt	ctgtatctgg	ccaggcatcg	tccttggctg
3661	catgttggtt	ttggcatcag	aggcagctgc	ctctaagccc	ttgttctgcc	atttcaagtt
3721	atgtattctt	aggcagatct	tttcatcttt	ttatacttag	tttcctcctt	tgtaagatga
3781	gaaagatagt	atcttgcagt	gtacttgtgg	cgattaaaga	ttatatttac	acgcatacca
3841	ccaggcacac	cgtagacacc	acacgaattc	tagctgtcat	attccaggcc	taggctagaa
3901	tgttgtcaga	ataaaagttt	catattcttc	ccactaatca	aaatactctc	accaccacca
3961	ctactgctat	tactacttct	acctaccatg	cattgagcac	ttatttgtgc	tgggaacttc
4021	actaggtact	ttgctgcata	agcttggttt	gttttatact	ttaaggaccc	cacaaggtag
4081	gcactatttt	tagccccact	tggtcactga	gataaatgag	gcatgatgag	gttacattgc
4141	tcaaggtcac	agaggaagtg	tctaaccctg	gctctgtctg	acccaaagtt	actgatctga
4201	aaacgatgct	acgccttttc	tagaaaatga	gccaaacctg	caccccaccc	tacaaagcag
4261	tccctgcccc	cctgaccctg	ccccaatcct	tagaactacc	tatcttcttt	gtattcatag
4321	ctcttccaag	caggagtcca	tcagcactgc	aggctgagca	caacatacca	gcttttgggt
4381	cagacaccag	ctgctgaaac	aggcccttca	atctgttgta	ctccccagaa	ttgcctctga
4441	tccttgcctg	acaaccatcc	caggatttca	gatcaagatg	tctgaggcag	gcccacttct
4501	aggtattttt	tgaaaaaatt	tgttacaggt	gacagggcgt	ggtggctcac	acctgtaatg
4561	ccagcacttt	gagaggctga	ggtgggagga	ttgcttgcgg	ccaggaggtc	aagaccagcc
4621	tgggcaacat	agtgagaccc	cagtctctac	aaacaaataa	aatttaaaaa	tcggctggtt
4681	ttagtggcac	gcacttgtgg	tcccagctac	tgaagagtct	gaagcaggag	gctcccttga
4741	gcccaggagt	ttgaggctgc	agtgagctat	gattgcatca	ctgctctcca	gactgcatga
4801	cagagagaga	ccccgtctct	aaaaaaaata	aaccaattgc	tacaggtaat	tgattctgat
4861	gacgatgctt	gcttgagaat	cctggagaga	tcctcgctgc	cttgatagaa	gctggggact
4921	ttagggggac	cctgaactcc	atctgaactc	ttggttattg	actgctctct	acttctctaa
4981	agagacggct	gtaaaaaatt	gacttagaaa	gccactcgaa	aaagttcaca	ctctgaactg
5041	cctgctaact	cccatttcct	accaaatcaa	gatgaacact	ttgcttgact	ttcacaatgt
5101	ctagcatctt	cacagtcccc	tgtattcctg	tacaacctgc	tccttctctt	ttctttgcta
5161	tcacggggac	accctgtgta	catttaggcc	tagagttttc	ttctaacctt	ggtgtcaaag
5221	tgtttccaat	caccaacgag	ctttcaaggg	gacaagaaag	ttccttctct	cctattttca
5281	ttggtcttct	aacagcaata	aaatttctac	acacttcaag	agtgtccacc	tggaaggaga
5341	aacatagtga	aggatgcaaa	tgtccatcaa	caaagtgcat	ctgtgtcaga	aagaactcag
5401	gtacaaatct	gtcactgcat	caggtgggag	ctctaaggct	ccactttgga	cagcggccag
5461	gagaggattt	ccaaagagtt	cgagttcctc	ccgcccggcc	tggacagaat	caggcaggat
5521	tatctgacag	gaggatgctg	cagtggttcc	tgagtgtgtg	cacatctcaa	cccccaatgc
5581	tggtgggaaa	ggaaaataaa	tcttggggcg	cccaaatcac	taagctaaag	ggaaaggtga
5641	agctgggaac	tgctcagggc	aaacctgcct	cccattgtat	tcaaagtcac	ccctctgctc
5701	acagagataa	atgcttattt	gattgcctcc	tttggagagg	ctagtcagaa	actcaaaaga
5761	atgcaaccat	ttgtctctta	tctacctttg	acctggaagc	ccctcccctg	ctttgagttg
5821	tcccgccttt	acttcgagtt	ctcctgccct	ttccagactg	aaccaatgtt	catcttacat
5881	atgttgattg	atgtctcatg	tctccctaaa	atgtattaaa	gcaagctgtg	ccctgaccac
5941	cttgggcaca	tgtcatcagg	acctgtgtca	tgggcatgca	tcctcaacat	tggcgaaata
6001	aactttctaa	attaactgag	acctgtctca	gatttttggg	gttcatactg	gctgcacccc
6061	tttccatggg	gttgctgccc	cattctctcc	tccatgggag	ccgaacaaag	tccaaatcag
6121	gacgttgcca	cacaaaacaa	cacaaatgtt	gtattattca	aataggagag	aggctcggtg
6181	ctgtcctcat	ttgggttatg	cctgcagtcc	agaggagcag	agtttggtgc	atggggagaa
6241	ctgaatgtcg	agggcttgac	agcctgttcg	cttggctcct	ctgtcctgag	attacattca
6301	ggattttctc	tttggcctga	agttagggag	gtaggtggaa	caagggtgac	ctttggagtg
6361	gaattttcat	aaaataaata	aactggatga	cagcgtataa	aagttacaaa	cctctttaga
6421	atgccatatg	tgagcaactt	gtaaacagtc	cataaatatc	acctgcaggg	tggaagtcaa
6481	ggaggctgat	gcagaattct	gtaggaacac	attttctgca	acactgaacc	atctggtaac
6541	gacaatttat	tctctggttg	gcataggagt	acaatgataa	aacatgttac	tactgacttc
6601	tgtctggaaa	aagacgatca	cggtccactg	tgttgtgtgg	acatggggcc	agtgcgcgtg
6661	actctcagcc	actcatatgc	cctgtggtgg	tgtcaggaga	ggaattaaaa	aattaaaggg
6721	gtgttttttg	gacatcccta	ctccacaagc	aggatttcaa	cagcaaacaa	caccaagaaa
6781	aaaaagtttt	tggagaaaaa	ttgttccttt	cataataatg	ccactttttg	agcgattcgt
6841	tttttaaaaa	gttcacaaac	atctgtgtca	ttcttgggga	ataagtgtag	aaagaacata
6901	tggatagcaa	ctttaccctt	tataaacatt	gcttattttc	aatatcccaa	taattagttc
6961	tagaataatg	aattctgcaa	aggataacaa	ggtctttcct	aggttctatt	tcacatagag
7021	aatttataaa	aagaaagaaa	aagagagcaa	gagacagaga	gagagagaaa	ggagttttga
7081	ttttcctcca	aatagactac	ttagtacaga	gtctctgtat	aataaaaaaa	aatttccaat
7141	ttctccaaag	tgaagaataa	tgtaacaacg	gaaacgcaac	tgaaggagat	gggctaatgg
7201	ctttattata	acaaacacac	atacaaacta	gacgcatttt	aatgtcatta	tcccctaccc
7261	cacccaacac	caaccttcta	actgtgcttt	taatcaagaa	ttccttctta	tgttgttact
7321	tcctgccctt	ctgggttcct	atgatatgca	gtttccatcc	tggtctcatc	ctgtttggcc
7381	cctttgcgta	aaagctaagg	atggctggcc	cacagcctac	cagggctttc	aaagccccag
7441	aagtctgtaa	acaggaaaga	tttcctctga	ggttgtgggc	tcctccttga	tcaaaagatg
7501	gctattggat	aagaacttcc	cctaaattgc	cagccactct	tattttccag	atgagatcct
7561	ctgttggagg	gtacattact	aggtatctat	ggcagaggtg	acaggcaatt	tgccaggact
7621	ccatgaagtt	gcaggagaag	taagttgcag	ctgctctgct	gttaatgagg	aggtagggct
7681	tggagaaaca	caaagattcc	tctgagcaat	ggccctggca	ggggtcccct	cctggttagc
7741	agccagggag	ggtgagcgaa	gcaaacatca	gttcagaata	tgaaagaggg	acagaaggac
7801	tgcatgaaga	gccccagcaa	ccttgagggt	ctcagaggtt	ggaaataaga	ataatgactt
7861	ccaccaaaaa	agtttagttt	tatccccatg	gttggtaagt	ggcctgtttt	tgagaaatgg
7921	gaggatagtc	aatgacttcc	tagttggaga	catcattcca	tgtaaaagga	ctgcttaggt
7981	ctgtttttag	ggtcaacttt	agagtcacag	ctcataattt	caaagttggg	tacatctttg
8041	tccaaggcag	cgaatctttc	ccccgtgatt	tcattatgag	ctaaccagtt	caggcaaaaa
8101	gctgtccctc	aagagtcact	caagaatttt	gcatttattt	ctagttaatc	acacctgtct
8161	ctgaaccttg	ccatggaaga	gtgaagtgag	ggagagaaca	aagcttttcc	tctaccttct
8221	ttctaaactg	ggtgagtaga	tcaaagtgta	ccaaaacaaa	caaacaaaca	ttttcgaaag
8281	accttctttc	ctgaatgcat	cttatcttgg	aacacatcct	tctttgttaa	ttacctgaca
8341	agaagaaagg	atgctttgaa	ttcttatcgt	agatttctct	gcaccactca	gagggcactt
8401	aataaattat	cttcttccat	ttactatctc	attatttgga	taaacttcat	cttttgaaat
8461	agattataaa	cttttcaatc	ccaggggatt	atagcgtagt	tcttcgcccc	ttccttccat
8521	actttttagg	tacgagcatc	ggtaaacagt	ttcgtattta	aactctactt	tatttcattt
8581	ctaattgaca	atgacctggg	ccttacttca	ttgtaataag	gaaacaaaat	gatgaagcca
8641	gaacttgcag	atggctgttc	tgtctgtttc	agtgtctcga	agtcagaggt	tggtggttaa
8701	tgataagaaa	gtaaatgtta	aatgtgcttt	tgcacattta	gcaaacagac	tgagaaccaa
8761	cttagaaaac	attttattta	caYtttagtt	atagcattca	ccttcttaag	atataacata
8821	tctgtttgca	agtcctgact	ccccacttga	ccgtgacccc	ttcaaggaca	ataaacaagt
8881	cattgtccat	ctttctatac	ccgtgtagta	ctcactatga	tactggcata	tgatatacac
8941	tgatataagc	tccagtgttt	tctctgatta	acatcaaata	atattgtcat	gacaatgaga
9001	aataagaaat	gtaggttctg	attttttccc	aaatcttgag	aatctgtttt	tccttcaagc
9061	tataaattgg	ggattcaacc	aaatcacatg	aagcagcaag	tatttcctgt	gtggcactta
9121	gctgttctgg	gaaataactc	aatgtcattt	ggttaacaca	cacacccagg	ccaaatagtt
9181	gaaaataacg	gaaagacatc	atggtaatta	ggttaggagt	tgacccaaga	catgttctca
9241	ttaaaattct	ttctatttct	ggtctccatt	ccgtcttctt	tcactgattg	acttttcttt
9301	ctttgaatga	aattccctcc	cccagatgga	ctatttcacc	acagcaaaaa	attgagaaag
9361	ctaagaagac	aatggggagg	aaaaccaata	ctaccaaaag	gaaacctcgg	agagttttgc
9421	tttctgtgag	ttctctgtca	gtcaaccctg	tcctgttcta	taagaccctt	ctcatagacc
9481	cctctttcaa	gggttttcaa	aaaggaaagc	ctatttattt	acttattacc	aattatgacc
9541	tcactggtct	tcccactctt	tagcactagg	gcaccagaac	cccagtgtat	gatgatggtc
9601	ccctagcagc	cattccaatg	acattattca	actcaaacag	agctttgcaa	taagctgtgt
9661	ctttccttat	gttctctggg	ggatgaaatg	agaatgaccc	catctaaaca	aaagaccaca
9721	tggttggcat	tcaacagtcg	actcctcccc	atttatttgt	ggatccaatt	cagtctaggt
9781	ctgaggcttt	acagaaatgc	atggcactcc	tcacagatgg	catctggcca	ccccttgaaa
9841	gcttctggtg	gaaggggagc	tcgctgcttt	tcgaggcagt	ctgtcacacg	agtagaaata
9901	gcgtagaaac	ccatatgtct	tgagtctaag	caatgacatt	caaaaagcag	aagcatccat
9961	gcaaccagat	tgacttaaag	taatgtaaac	agtccaatcg	attctttgaa	attgaagaat
10021	gacttgctgt	agagcattgt	gctccatgat	ggtgtgttct	gccagcctag	gcatgagcac
10081	tttgtggtag	tacaataaac	tactccaYag	cacatgggga	ggagaatgtg	aatcaatgat
10141	ttagtgtgat	ctcattggta	actcagtgct	gaagatctgc	tatcatatat	ttaggtgaat
10201	aactattcca	atgtgctgga	tggcacttta	caaacatata	taatctacaa	aaatgattta
10261	aaaaattttt	gtgcaccttt	caagtcaaaa	tagctcaaga	tataatgtgg	acatcctagg
10321	aaaataataa	ttgatgcatg	ttggaaacct	tttcatggta	tattagggct	ataatttcta
10381	cccattggtc	cctgttctgc	ccttaaggat	gacacagcat	aagttataaa	cccctgaagg
10441	tctagctgca	aaatgggtgc	atgcactccc	aaacaccaga	tcgtgattat	gcattacctg
10501	gaaaagtaag	aagtagggaa	agcaatatgg	ctgaagacaa	gtgtgttcag	tgaggggatc
10561	gttgtctcgg	gaatcctggg	aaccaagttc	tcactgtgga	cccactcact	gggcaagtca
10621	cttcctgcct	aaactccact	ttctctaccc	atcaactaga	gaggtcagat	tctccgttag
10681	ctgccaaaca	gtacatgggt	aaaattctat	aggtttaaaa	aatcatatac	catgactaaa
10741	agtctatgat	aacgggaaca	caattttggg	atctctttgt	aaaaaaaaaa	aaaaatctgt
10801	tctttttttc	ttttttcttt	gagatagagt	ctcactgtgt	tgcccaggct	ggagtgcaat
10861	ggcatgatct	cagctcactg	caacttccgc	ctcctgggtt	caagagattc	ttctgcctca
10921	gcctcccgag	tagctgggac	tacaggcaca	taccaccacg	cccggctaat	ttttgtattt
10981	ttagtagaga	tggggtttca	ccatgttggc	caggctggtc	tcgaactcct	cacctcgtga
11041	tctgcctgcc	tcagcctccc	aaagtgctgg	gattacaggc	gtgccaccgt	gccaggccag
11101	taaaaaatat	ttctaaccaa	aattttcact	ccagctgtca	tacatgtagg	gaagtgattg
11161	tttatattaa	tttgcaaagg	ctaaatccat	ttttcccccc	aactctttgt	gacttgcttg
11221	ggctagcctg	caaaaacact	tctgttcatg	gcagagagct	gtctgcatcc	agctgacatt
11281	gtttctctgg	cttaaataaa	agaggcagga	caatgagtgt	taaaccactg	ccggactctg
11341	atgtagtgtt	tacgaaggca	gctgcttttg	cattctgcgg	gtcagaaggg	tgtgtgtgtg
11401	tgtgtgtgtg	tgtgtgtgtg	cacgctcctg	catctatgta	agatctgaga	atcactgaaa
11461	gcagcttcct	tcatcctcta	ttttgacata	aagattctga	attcaaagca	ccttcagaag
11521	caacaagaga	ttaagacagg	ccaggcaacg	acttaatatg	gtaaaacata	tcttatccct
11581	gtggtcagtt	tacaatttcc	ttgacagata	actgctaatt	aagacatatt	atttcagaaa
11641	ttatggttNa	tttcctttgt	tatttacact	tttgttaaag	gtagtcaatg	atgtctttta
11701	gctgctcaat	aaagggtcac	ctaaggaaaa	gcaactgtat	gcctaacatc	tgggaaaaat
11761	attcccaatg	gggtaggttt	catgagaaca	aagttatttc	tcagatgact	ctttccttgc
11821	agcttcaagc	tttgttttcc	taggaattgt	gtagaaatgc	tggaattaat	gagtgataga
11881	gactttgatt	gaatcaatat	tgtgtgaaat	taacttgcaa	acatggttgt	gattactttt
11941	gtgggagttg	gactgaattt	ctcaagaaag	tacacaaaga	aaagactcag	ggcagagcta
12001	cagctgcctg	acagaggcaa	acagaagcct	aactttatgg	acttttccat	actctgcata
12061	tgttgaaatg	acaggctgat	tcatagcttc	cttgcttagt	ttccaaatcg	ctttgcaaca
12121	aaagcagatt	tactcccttc	ccaagactat	aactaggatt	catgatccca	taggctcaaa
12181	tcttcataaa	gggaattttg	caaagcatgc	ctcccaattc	ttgacagtca	caattcaaat
12241	attttcacaa	aacaacagga	ctctcaatta	agacagaggt	cagcaaacta	tggcctgtag
12301	atcaaaccta	tctgactgct	tgtttttgta	aataaagttt	tattggaaca	caaccatgct
12361	cattcatttg	cctattgtct	atggctactt	tcacagtatg	acggacgagc	tgaacagttg
12421	agattgaggc	tgtcttgcat	gcaaagccta	aaatatttcc	tatctggccg	ttttcagaaa
12481	gtgtgccaat	tcctgattta	aaatatcaat	ttgtgccata	aaaaaaaatc	aatttctttg
12541	aaaacataga	tatagtttta	aagtaaacct	ccccaacctc	ccctacctcc	atgaattatc
12601	ttctaaagca	aattggagta	tatatcaaga	gtcttaatac	tggttttatt	ctttagttca
12661	gcaaccacac	ttctagaaat	ctcttctaaa	gaaatcccta	agcatacatc	aagatttatg
12721	catacagatg	ttcattccat	cataatttat	aattatttat	aatcttgaaa	aattgaaaat
12781	gtcctaaata	ttctaggcca	tttagataaa	aattatttta	gaaagatgtg	atttaccaaa
12841	tgcttgtttt	taaaaatatt	taaagaatta	ccatttgacc	cagtaatctc	attactgggt
12901	atatacccaa	aggaatataa	atcattctac	cataaagaca	catgcacaca	tatgttcttt
12961	atagcactat	tagcaatagc	aaatacatgg	aatcaatcta	caagcccatc	aatggcagac
13021	tgaataaaga	aaatgtggtg	catgtacacc	acggaatact	acgcagccat	aaaaaagaat
13081	gagatcatgt	ccttttcagg	aacatggacg	cagctggagg	ccatcatcct	aaatgaacta
13141	gtgcacgaac	agaaaataaa	atagtgcatg	ttctcattta	taagtgggag	ctaaacattg
13201	aatacatatg	ggcgcaaaga	acaacagata	gcagggtcta	cttgaggatg	gagggtggga
13261	ggagggaaag	gatcaaaaaa	ctacctattg	tgtactgtgc	ttattacccg	agtgacaaaa
13321	taatctgtac	actaaaccct	tgtgacatgc	aatttaccaa	tataacaaac	ctgtacacgt
13381	acaggtttat	atataaaaca	aaagttttat	atatatacat	atatatgtat	ataatatata
13441	tatttaagag	cctaatataa	tgttttacat	gtaatttcaa	gagaaaatgg	taggataaaa
13501	gctgtctata	gaaaataatc	tcattattct	ttttttttga	gatggagtct	cactctgtcg
13561	cccacgctgg	agtttagtgg	cgcgatctcg	gctcactgca	gcctctgcct	cccgggttca
13621	agtgagtctc	ctgcctcagc	ctctggagta	gctgggatta	tgggcatgca	tcactatgtc
13681	cagctaattt	ttttgtactt	ttagtagaga	tggggtgtca	ctatgttggc	ctggctggtc
13741	ttgaactcct	gacctcaaat	gatctgcctg	acttggcctc	ccaaagtgct	gggattacag
13801	gtgtgagcca	ccatgcctgg	cctcaatttt	tttaaaaaat	gcatatttct	aaatgcaaag
13861	aaaataagca	gaaagaatat	atgccaaaaa	tatatatttt	aaaattcatt	tcagataatt
13921	ttgtgctcaa	gaaaaataaa	tatacatgcc	tttttgttta	atttatgaaa	atgttagtcc
13981	caaataaagt	tcttcttaat	ttatagaaat	gttagcccca	aataaagtta	gtacccattt
14041	aaaaatgagt	attaacctat	ttccaaaaca	gtccactttt	taatgtaata	aaaattaaat
14101	attttctaaa	atattatttt	tatgaatcac	attatctttt	catagatgga	gcagagatgg
14161	cagttttggg	gcacttgtgc	tgccactttt	tcctcttgcc	cacactgaac	actgcaacct
14221	attaagccat	ttctttctaa	gaagtttctc	aaatgtacta	cagatggcca	ctactaatca
14281	gtcagaagta	ttaagtgata	tcaaacatat	ttgccctctg	tgagagggct	acataagttt
14341	tccaagttaa	ttccaccctt	cctcttaaga	ctacatggtg	aaatacattt	ttatcaccgt
14401	agatcttgat	catcttgctt	cgaatgtctt	agaatgttct	gcgtgtattt	ctttcaaatc
14461	caaagaaatg	cgcggtgtct	cttcatatgc	attcaatgct	gaatgtctgt	gttaggatgt
14521	actgccccaa	gggctgggtg	aagctgctgc	ctcaagggtc	ctggtgagcc	tagttactgt
14581	atcgcccatg	tccacaattt	cctgtatttc	tttctagcac	ctgacactgt	gaacaatgct
14641	tccgtttttg	aaatgctcac	atcagcagct	ttctgtagca	agacactgtt	gtaactggta
14701	cctctctcat	aacgccttcc	cattgtcctt	ggaacaccct	ctaaccttaa	tccatcccat
14761	caagggggct	ttttctcgag	acatttattt	cttttctttt	tctccttgcc	cttctacgaa
14821	aagtcaattt	ctacagcttt	agccaacaag	tgattcccac	atttctatgt	ccagctttgc
14881	ccagtttccc	gtttctcaag	ttcttttttg	cacatctcta	cctgcaatgt	ttaaaagcct
14941	ctcaaaatgt	tcgaaatagg	acctactctc	ttgctgtatt	tgcctttttt	tttttttttg
15001	agacggagtc	tcgctctgtc	gcccaggctg	gagtgcagtg	gcgcgatctc	cgctcactgc
15061	aacctccgcc	tcccgggttc	acgccattct	cctgcctcag	cctcctgagt	atctgggact
15121	acagacgccc	Rccaccacgc	ccggctaatt	ttttttgtat	ttttagtaga	gacggggttt
15181	caccgtgtta	accaggatgg	tcttgatctc	ctgacctcat	gatctgcccg	cctcggcctc
15241	cgaaagtgct	gggattacag	gcgtgagcca	ctgcgcccgg	cctttttttt	tttttttttt
15301	tcgagacaga	gtcttgctct	gtcgcccagg	ctagtgtgca	atggcaccat	ctcggctcac
15361	tgcaacctcc	gcctcccagg	ttcaagcgat	tctcctgcct	cagcctcccg	agtagctggg
15421	attacaggtg	tgcaccacca	cgcctagcta	atttttgcat	ttttagtaga	gacggggttt
15481	taccatgatg	gccaggctga	ttttgaactc	ctgacctcaa	gtgattcact	cgacttggcc
15541	tcccaaagtg	ctaggattac	aggagtgagc	caccgcgccc	agctgcttta	tttactctta
15601	gtgttactag	taccactgtt	ctttcggacc	caaagatgga	aacatttgta	tcatcattaa
15661	catcctggcc	tccatctcct	ctcaaattct	atcactggtg	gagtcctttc	catgtttcct
15721	tcaggacgta	cctttctttc	taattttact	gccgccagtc	accttcagag	agtggctggg
15781	gttctttcgt	gggaagaaat	aagcgtgaaa	tggaaagaca	aagcattcta	ctaatgtatt
15841	tagtttttaa	catttattgg	ataattatta	tttttagacc	ccggcttggg	atgtggggaa
15901	gaaaagacga	cctacagttt	ctatttattg	tttctgttca	atttgtgcca	cttgaagagt
15961	cagtaaaatg	acgccaagac	cataaaccaa	ttccaaaaag	tcagagctga	cttggttcag
16021	tcccctttga	agagataagg	cctgtcattc	cagagtatga	ggcacagcag	gctggtgagt
16081	gtaaaggggt	tgattgggac	ctagaattat	aggcaaagaa	gacaaacatc	taagttagag
16141	ctagcagagg	gtgtctaaca	tggagaatac	gcatatgcta	gtcaagtgtc	cagggtcggg
16201	ggattgagtg	accttgggaa	acaagagtat	tccagctgat	ggctgaatct	cagagggtct
16261	aggaccccag	cagagggtta	caagtagaga	gcaccagcaa	ccaggaacaa	acctgatcct
16321	cagccaacaa	ttgcctctgc	cagatgtttt	ttatatgcgt	cttgtttaga	gcatgatcta
16381	ggtcccaggt	gggcctgcct	tgggggctgc	agatgaagat	aatgaggttc	tgcaagctgg
16441	aaaggcatgg	aggccactcg	gagaacagcc	cctgagtagc	aggtctcttc	tacttgtcag
16501	tgtctttcta	gagaataaat	atcacaaggg	cagagaatga	tgcctgtttt	gttcactgat
16561	ctatcactgt	ctctatcact	atcgctatca	gctgtcacag	tgatcggcac	atactggttg
16621	gtcaataaat	atttattgaa	tgaatgaatg	aatgtggtag	taagcaacaa	atgaagtttt
16681	cagaagaaga	attctggtgt	cccaagaaac	aatgcttggg	aaagtgcctg	aatctccctc
16741	aatttctgag	tttgtaagtt	ctgaatttat	taccacttat	atatattttt	aagcacatgt
16801	tgtgatgaat	gtttaaccat	gacctcatgt	tcaacatcaa	tctcaggact	tgtataatat
16861	tccacatata	aaccaaaccc	taaaacaaca	ttgataagaa	acaggaacag	tttaagtcgc
16921	aaggccagtc	tcaggaaagg	tgtaatgaca	aaaataatgg	gagttgacag	ttcaaatcct
16981	ttttttctca	taacagtgtt	tagaaatact	agacattttc	caatgaatgc	tgggaattag
17041	ctgaataact	ttagaagtta	gtcctctgtt	gagcacttgc	tttaacaaaa	atatggctca
17101	ggaggaccaa	atggaggaga	aaagtgcaat	taatatattc	actcatttta	ggtcctgttt
17161	acatttgcat	cttgaaggaa	ttgcatttat	tattttaatt	attttttaaa	tcaagtttcc
17221	tgtctgtaat	tgaatcatta	atagggctct	ttagtcttta	ttggtgacaa	acacatctat
17281	gtttaaattg	ctcagaattt	tctagtcaga	tgtgctaagg	acacattcag	aaagaaaaca
17341	agtttaaaac	acatctgtgt	ccttgtttag	cctttgaaaa	gctactttat	cattatacat
17401	tttgggcatt	tcctttaaaa	atgggtctgg	tacaactaaa	ccatttccca	aggatgtgtg
17461	aattaaccag	tggttacaaa	gagcttcgaa	atgatgatgg	actatcagtg	ctaagtcaaa
17521	ttatgaaatt	gcacctttgc	aaaaatgcta	ttgtaggaat	aaatgaatct	gaacgtggta
17581	tttacagtgt	gatttgcttc	tgaaatagaa	tatttctaat	gggcctctgc	aggcaacaac
17641	aaagtgccat	cttatctcct	gttgatagac	cacaatttca	gaaaattatt	tttacaatgg
17701	catctgaata	agctccttaa	tttgagactg	ttttccaaat	agatacatag	cttattactt
17761	tgcttacgct	gcctttgaga	cacaaagagt	gaggtgggat	tcattaacaa	aatcgctgtt
17821	gtcattcctt	tgtggttttt	ttttcaaagt	aatttctctt	ctttacaagc	taatgttaat
17881	gagctatgtt	gaataaaaag	atcaggtaaa	agctactttt	gtgttagtga	tcaaatccga
17941	gtttgggtta	atactcaggt	tatcaattgc	acttaaagca	cacctcaaac	ttggtttgcg
18001	gctcctgtag	tttgaagacc	aaaccaatca	ctcatgtatg	gaatttctac	tgactgtgaa
18061	tgttatattc	aacaacagca	gaacaataca	tgtgtatttc	agaagaccac	attctcagtt
18121	cttctaaata	actgattaga	taaaatgcat	ctgttcatgg	gtaagactaa	ggtctaggtg
18181	aaaaagtagg	caattcctta	gaataaattt	tgccaaaaca	aggtctaaaa	cgtctgatac
18241	cacttagggg	ttgaaaactg	acataaaaca	tgtgtctcag	tgaaatatga	gtaggaagga
18301	agagaaggct	gtgttgcaaa	agtcaaggag	ggtctgggct	gggctggaac	agcagcttgg
18361	atctagggaa	gaagaaagca	aaaagtaggg	agggtcttgc	aaagaccaaa	gaaagcccca
18421	gggatcagga	ccagcctcag	ctgtcagaaa	agacatctct	gattattaca	cattgtaggc
18481	ctgtatcaaa	atagctcatg	taccccagta	atgtataYat	ctgctacata	cccaaaaatt
18541	aaaagttaaa	aaaaaaagac	atctttgtaa	tatgctctat	ggcaggagga	ttttttctgg
18601	agaattagaa	tcctgttact	ttagagacaa	aagtgcttaa	agagaagagc	ttcattcctc
18661	tcatttcaca	gatgaagaga	caaaggccca	gaaagtctca	atacttgagc	tcacagctaa
18721	ttagagctca	agtgattcct	agaactcagg	atcacaatga	gtacctgcgg	gcatcacaca
18781	tgaagaccgc	accgttaact	gagcaaattt	cttgagagag	ctacggacat	ggtccacaca
18841	ggacgggcac	caaggagaca	aagctgaggg	cacaatcaag	agaagcttct	gcctctgccc
18901	cagacagtct	tttgtctttc	atcccatgga	aatggaaatg	caaacgttta	ttagtttatt
18961	acgtaagttc	cttccttcct	tccttccttc	cctccctctc	tccctccttt	ctctctttcc
19021	ctccctccct	cctttcRttt	tccttccttc	cttcYYtcYc	tctctYtctY	tctctctYtc
19081	tttctttcta	ttcctccctc	cctccctccc	tccctcctct	ctctctctct	attttcagag
19141	gtagactgtt	gcactgtggc	ccaggctaga	gtgcagtggt	gtgatcatgg	ctcactgcag
19201	ccttgaactc	ctggggttac	cgtgatcctt	cctccacagc	ctcccgagta	actaagacta
19261	cgggcgcatg	gcaccatgct	tggctaattt	tttaaaagtt	tttatagaga	cggtattgcc
19321	caggctgttc	tcaaactcct	ggcctcacgc	catcctccca	tcttggtctc	ccaaagtatt
19381	gggattacag	gcatgagcca	ctgtgtccag	cgtcatgtaa	atcattcttt	tctatggttg
19441	cagacaaact	agagaggtga	gaaggaggga	gtgctttctg	tttgtttcta	aaatagacag
19501	ataacagaaa	catttggaaa	tattgcggaa	aactaagtgt	aagagagtaa	cattgaagag
19561	ctagtaagaa	agataaaacc	agctgtggag	gctgggtttg	cctgttgtag	gtgtcatcat
19621	acatctacta	ctttgcctct	tcctcttggg	ctggcatgaa	cacattgtgc	cacacgcctt
19681	aagaaacact	taggaaacac	tggtatggag	ggagagggga	gagcccaggc	agcagtggaa
19741	tcctctcatt	gccccctcca	gaaacaagca	ggcctgggct	agttcctcca	agtagcatct
19801	ttgtctagga	caggaggctt	gttatttttc	tggtggtatg	gactgacata	tttacaccat
19861	tcttcaagga	acgcatccca	tgttaacttc	tctaatgaag	aaattcactt	tctgcctctt
19921	ccctggcaag	cctgctgtga	agttaacatg	tgcatttact	ggggttgcca	gctggaacgg
19981	aagcaggctc	taaattattt	gtgtttaatt	tatgtaaagg	tggtttggac	ctgagcccag
20041	atgtgaatat	acaatagacc	aagtttacag	aattgtgaca	caaagtccca	agagttgtgg
20101	ggatgtcaga	aaacactcag	caatcaggac	gtatgcctac	aacattaata	cattttatgc
20161	gttcaactcc	aaaacagatt	atggagacga	ctgtaagaca	gaaagaaaaa	ctttcagcca
20221	agcactatct	ctgcagattt	tttgagatgt	agctagagct	actcaaatgt	aaaaattcaa
20281	gcttttaaaa	atagaggttt	ttagggggaa	tatgtaagtc	tgactcacta	cccaggaaaa
20341	tgaagggttt	accatgtaaa	tgagaagaat	aagtgagcat	tttacagtat	gattaagtta
20401	agcctttgtc	cagagagctg	acttggtctt	cctgtgctgg	aggaacacac	tggagaagtc
20461	taattggatg	tccattggct	aactggagaa	gactcattgg	ttgtcaattg	gccaattgga
20521	gaagactcac	tggatgtcca	ttggccaatt	caatttggca	aatacagcac	ctactatatg
20581	caaaacacta	aactcggctc	tgagcagtag	aaaaacaata	ctagtctctg	taactactgt
20641	atgatcttgg	gagaatagtg	gaataatatt	aatgattaca	acacaataca	gaatagcata
20701	aggaacatga	atgaagtata	aaaacggttc	tgagaagtgt	cagaggacgg	agaaagaaag
20761	accgcattta	cttggtggct	ggttatcaaa	aatggcttca	tgaaggaagc	atcatttcag
20821	gtagaactag	gatgataagt	aacattttga	catggagtct	caggtgtgta	aagggcattt
20881	acccccacca	cacctgtgaa	ggaaacatcc	tatgcacagg	catggggctg	ggaaaaggag
20941	gagtgagctt	caagaactag	aaagtgacca	tttttggcta	gaatagataa	gggagccaca
21001	ggggataagg	ccagagagaa	ggccttatct	gcccttatct	ccttatttgg	cctcctgtgg
21061	ctcccctact	tattctagtt	aaaaatggtt	acttccttag	ggaaagccaa	gaagcacaga
21121	ccgaggcagg	gaggaaacgg	ggaactctaa	atgcttctga	gcagagggca	agaaggagga
21181	aaacctcttc	tggaggctga	tgcaatcgct	ccagggatag	gttaaacagt	gtttgcattt
21241	ggcaaatagc	tgcagaaatg	taacagaaga	gataggagag	acatcgtaga	tagataattg
21301	agaggccttt	aaactgacta	gatttggggg	acaaatagga	atcaggagac	attccagagt
21361	ttcaaatttg	ggtaagtagg	aaatgaagga	atcagtaaaa	cagagacaag	gcagaagaga
21421	agtcatttgc	ataggaagct	gcaaagtttg	tttttgtttt	taattttagg	aaatggtcag
21481	ttctccaggt	ggtcaacatc	ctccagaaag	aatttgtaag	tttgaggcca	acgctcacgt
21541	cagattcagg	aagctaggta	ttatctgagc	ctagtggcta	agatcaaaaa	gcttattcag
21601	aggaaaaatt	cagggcaaag	gcaaaacctt	ggccaatgcc	tacatttcag	tgttggagga
21661	gaaatagagg	caaaaaagag	aagaggtcag	agaagtgggg	agaaaaccaa	gatggcacag
21721	caccatgaga	tgcaggaRag	aagaaggccc	caacactggg	gagttgccaa	ttatgtataa
21781	gattgcacaa	aagttggaga	aatcagggcc	aagaaatggc	caatgttttg	aagcattaga
21841	agagccactg	gggtatttga	tttgagcaaa	cattttcagt	ccactggagg	gaatgttacg
21901	ctgaagttat	gctgtcatgc	tgaagacagc	taagtaagaa	agtggagttc	tgaactgcag
21961	tcaccacttt	caataccttg	acagtaataa	gaaagagaga	gagagtgtga	gacagagtgt
22021	gagagacaga	gatatatgaa	atgtttgctt	gcaaggtaac	aaggtccaag	aaggattttg
22081	ctactcacaa	agaggtagat	cctacagaat	tcatttgacc	catagaggcc	cataacagtc
22141	ccacaaaaaa	gaaagccaat	cccttctatt	gggtctccca	gccacatctg	tagccatttg
22201	aaatgaagaa	gcgttgagag	tgcttttgaa	gagttgcaga	tatagtgtgt	atcacataag
22261	gccattcatg	agggtgaggt	ggggataagg	agctagaata	gtaacctctt	ctctgccatg
22321	atcccaagct	ctttcctgca	aacatgctct	ttggtgttgc	cactaagaac	caactcccct
22381	ccctactact	ggaaaatctg	tcataaccag	aaatgcagga	aggagatggc	aaggtcaaag
22441	gacaggggat	actagaaata	gaggggaaat	gatgtgaatg	gaccatcagt	ttaaaaacat
22501	ttatttccca	gctgcctttc	gctatggatt	tatgctacaa	aatccatatc	attttctctt
22561	tcttggaaag	gaacataatg	acactatttt	gttgaatgga	ttgtcaagga	ctggcaaccc
22621	tgtgtaataa	ccacaaagct	attggcttga	atactgctat	ttatgtatgg	gttggcttat
22681	ggtctgaatg	cactaaacat	atttacaatt	cctcaagcac	acatgaaaga	ataatttttt
22741	taagtcattg	atgctattat	catcaagttc	gtgacactga	aatagcatct	tctatgaggt
22801	tttccagaaa	ctccatccat	ctagatcttc	agaaggctgc	cattataaca	aacttaactg
22861	gtcaacttac	tagaacactc	agaaattctt	attggctgaa	tgcacactga	gcatagatac
22921	tatctctgtt	gtgtgtatgt	gcagtgcctt	ggtgcttttg	aaatatttat	aagtgtctcc
22981	tcctaaggat	gcagacgtta	ctgtttacag	tctgaactta	tttaaggaac	caaacctgcg
23041	gatgcacttc	ctgttatagt	aatacctagg	tcttattatt	tataaatatg	tatgtgtctc
23101	ttgtattcat	aagacacttc	catctacatt	agctcatcaa	cactgtgttg	ctgagatagg
23161	tagaggaagg	aaagcacttt	tgtttcggaa	ttaaagctgt	gtctaggtgg	cattactcag
23221	gcagactctg	atgtaggcaa	cctggtcact	gtcacatctt	cctgggctgt	actggttaac
23281	actgtcaaat	ccacgatgtt	aatggtgcca	taatgagcca	ttcacatatc	gggacccagc
23341	ccatatgacc	catctcctgt	ctcacagaca	agaatgaatg	gcagaggtgc	aattataacg
23401	cacatcccta	attcaccaga	actctttttc	acagggagct	gctaacagga	tcccctgaca
23461	atccaaaatc	cccagcttgc	gtgaatgaac	taacagacac	atcagtttgc	tagaacagct
23521	gaagagggaa	atggtgatgt	ctggaaggac	tgaacctatg	tattctaata	gttactcagt
23581	agtgtcccca	gacacgagca	aagaaattgg	catggggaga	aacgggaaga	agaatgcaaa
23641	gctgtttcct	aaggaaaaaa	gaaatgacaa	ttccaatcag	tagtaaacac	acaaacaaac
23701	aaaatccctc	actgtttcct	tagcttagtg	ccaatcgtca	ttgaaaaata	aaattatggg
23761	ctgccctttg	tattaggttg	gcgcaaaagt	tatcgtggtt	ttggtggcca	aaaccacgat
23821	aacttttgcg	ccaacctaat	agcattgagg	aaggtgctag	cacagctttg	gtaatataag
23881	gaactctaat	agagccaggg	ctgaaatatg	ttccaaacat	ctgcgtcagg	cttggcagcc
23941	tgttcccagt	gtaactgatc	atggaagagg	gtgagaggtg	aagccaactg	gacttccggg
24001	gtcgagtggg	gacttagaga	acttttcttt	tctttctttt	tttttttttt	ttttttgaga
24061	cggagtctcg	ctctgtcgcc	caggctggag	tgcagtggca	cgatatcagc	tcactgcaag
24121	ctctgcttcc	cgggttcacg	ccattctcct	gcctcagcct	ccccagtagc	tgggactaca
24181	ggcgcccgcc	accatgccag	gctaattttt	ttgtattttt	agtagagacg	ggggtttcac
24241	tgtgttagtc	aggatggtct	ttatctcctg	acctcgtgat	ccgcccgcct	cagcctccca
24301	aagtgctggg	attacaggtg	tgagtcaccg	cgcccagagg	acttagacac	cttttctaca
24361	agaggtttgt	aaaatgcacc	aatcagtgct	ctgtaaaaat	gcaccaatca	gcgctctgta
24421	gctagctaga	ggtttgtaaa	atggaccaat	gaacaggaca	tgggtgggga	caaacaaggg
24481	aataaaaact	ggccccctaa	tctctgctca	ggtccccttc	caggctgtgg	aagctttgtt
24541	ctttccctcc	tcacaataaa	tcttgctggt	gctcactctt	tgcggYggtg	ccatcttttt
24601	tttttctttc	tttctttctt	tctttttttt	ttttttttga	gacagtgtct	ccttctgttg
24661	cccaggctgg	agtgcattgg	cacgatctcg	gcttattgca	agctctgcct	cgcgggttca
24721	tgccactttc	ctggctcagc	ctcccaagta	gctgggacta	caggtgccag	ccaccatgcc
24781	tggctaattt	tttgtatttt	tagtggagac	ggggtttcac	catgttagcc	aggatggtct
24841	cgatttcctg	acctcgtgat	tcacctgcct	ccgcctccca	aagtgctggg	attgcaggcc
24901	tgagccaccg	cgcccggcct	gggtcggtgc	catctttaag	agctgtaact	ctcactgcga
24961	aagtccccag	ttccgttctt	ggtcagctag	accgcgaacc	caccggaagg	aataaattcc
25021	ggacacaagg	gggcgcgcgg	ggcatgcgta	aaagcctgct	ccggggccgg	gcgtggtggc
25081	tcacgcctgt	aatcccagca	ctttgggagg	ccgagatggg	cggatcacct	gaggtcagga
25141	gtttgagacc	agcctgacca	acatggggaa	accccatctc	tactaaaata	caaaaaatta
25201	gctgggcgtg	gtggcgtgtg	cctgtagtcc	cagctacttg	ggaggctgag	gcaggaaaat
25261	cgctggaacc	caggaggctg	aggttgcagt	gagccgactt	tgcgccactg	cactccagcc
25321	tggcgatgga	gcaatactcc	gtctttaaaa	aaaaaaaaaa	aagcctgcac	cgggacccag
25381	tctctctcca	gacaatccgt	agcccttaac	tgtgctgctg	ggaaccagag	gccccaaaat
25441	tcaaaatcag	gtgcctctga	ttaagctaga	gggagtgagg	aggagcggat	gtggccagat
25501	tctctgaatg	tggacatgca	ggcacccact	ccaacaccca	gggagtggct	gtcttaagtg
25561	ctttctgaaa	ggttgtcatc	cagacaaacc	acccacttca	gcagttattg	aaattgcccc
25621	tttcactctc	tctttgctga	atttttgctg	atctcttctc	catatgacct	actgtgggtc
25681	acagacgctt	ctcagggaca	cattgcggtt	tttcacctca	actcttcata	tacctcattt
25741	tgagttcaat	acaagtgtca	gctgtttaaa	ctagtgttta	catgtgcaaa	gcattctgtg
25801	ggacagcgaa	aggtagaaat	gtaagtaaga	catggttttt	gtcttgctgg	ggtctgccac
25861	ccaaacgaga	gatgaacacc	tgtacagtta	gaatgaggac	tctacggaga	tgggtgctgg
25921	aaggcaaaat	agagtgctgc	agtcagactg	tcacattaac	tggaatttgt	caacttgact
25981	ggctgccatc	tttccaaaag	agttgatcta	gaaatttaca	ttttatttat	ttatttttga
26041	gacagagtct	cgctgtgatg	tcccggctag	agtgcaatgg	cctgatcttg	gctcactgca
26101	atttctgctt	cccgggttca	agcgattctc	ctgcctcagc	ctcctgagta	gctgggatta
26161	caggtgcgtg	ccaccacatc	tggctaattt	ttgcattttt	agtagagacc	gggtttcacc
26221	atattggcca	ggctggtctc	gaactcctga	cctcactgat	ccgcttgcct	tggcctcgca
26281	aaatgctggg	attataggtg	agccaccgcg	cctggctaga	aatttacatt	ttattttatt
26341	tttaccatct	tttctgtgac	caaatgtgtt	aacaaacaaa	tgcccacttt	ttcactttat
26401	tggagaataa	aaaggacaga	caactatgaa	ctgagatttt	ttttaaaaga	taaaacagtg
26461	atcttagtta	gccaggggtt	accacatcta	aaacagccta	atctcttatc	agaccaagtc
26521	agccttagct	cctccaggtt	tgtagagact	tgtgtctgtt	ttttaatctt	taagtcaaga
26581	gtgtgttcct	tttttcttta	aatgtaagaa	tgtatgcctt	taaatatttt	gaagtgatct
26641	atgtaagatt	atgattttga	ccccgtctta	attctttcca	tgccacttcc	tgggttgctt
26701	gtatcttgca	taatagctgc	cctgctggta	gcgtccaaca	gttaagagag	tcagacaagg
26761	acttggaatc	gtgactatat	tgactggcct	ttgctatctt	cggctattct	ggagaaatat
26821	gagaacttga	attgagagac	agttagcatc	ctctttcagc	ccgggactgg	aagctctctc
26881	cgtgacatag	cagtctatca	tagaagcagc	aggccatcac	ctccaacctg	gctggctgct
26941	tgtacaaagt	atccacccag	ataaaacgaa	atacactgga	gcatctgttt	cttctcagaa
27001	aactcttcca	tttctcctag	gaacccagtg	cctgagcagt	ctccctttaa	cccttacaga
27061	gccaccgtgg	caaatgcaag	gatcgaaact	gtatgaatga	gggcgctgtg	ggagaagaac
27121	acttccctgc	tatttacctg	agattaagta	gatgaccagc	gcttggaagg	gaatgtggcc
27181	ttctcacctc	tgggcctgag	aacaagcact	ggacacagtg	gtatctaata	tgccctttta
27241	ccaattgaac	agatcaaacc	catgtgtggc	ctggttgtca	ggctttaaat	aaacattgta
27301	tttatatgcR	ctttgtgctt	ttaaactcca	tcaacaaaaa	gcactagaat	ttagatattt
27361	actccccagg	atttccattc	ctaagttaag	gcaagttttt	atttatttat	ttgttttttt
27421	aaaaactgaa	ggatagagtc	tcgctctatt	gccgaagctg	gagtgcagtg	gcaagattat
27481	agctcactgt	cacctcaaac	tccaaactcc	tggcctaagc	gatcttcctg	ccttggcccc
27541	caaaagcact	gggattacag	gtgtgcacca	ccacaattca	ctaatttttt	attttttgta
27601	gagagagggt	cttgctatgt	tgctcaggct	agccttgaac	tcctggcctc	aagcaatcct
27661	ctcacctccg	tctcccaaag	tgctgggatt	acagacctga	gccaccactc	tggccaagtt
27721	tcaattgagt	ggaaaaccac	caattggttg	aaagtttcta	tgcacagttt	tcacaagtgc
27781	ttatttaatc	tgaacttaaa	gttcaaaaat	taagtccttc	ctcagaatta	gttggtttat
27841	acttaaactt	tcctgagaac	ttgttaataa	aagagttgct	tgaagaaaaa	ataagctggt
27901	aacgtttcat	gagaatttcc	tcattcaaaa	agcacatcca	tgtgtgactt	tgatcacaaa
27961	gacagaaaga	tttgtgacgc	agcaactatt	tatttgggtt	ctgttcatat	gacttttccc
28021	agcttcaggg	atctcagctg	tcaaatgagg	atgagagaaa	agtgagtgct	catccccata
28081	atgggcacat	attgaagact	caacagcaag	agcccggcat	aggttggaca	tggtggctca
28141	ggcctgtaat	ctcattactt	tgggaagctg	agacagagaa	tggcttacct	caggagttcg
28201	agaccagcct	gggcaacata	gtgagaagcc	cccccatcct	tctgtgtttt	aaataaataa
28261	ataaatatgt	ttttcaaaaa	aaaaccagtc	ataattattc	cttcccaaac	actctatgat
28321	tatttaagtt	aaagaagaaa	aaaacaacat	gttgaccaaa	gaagatctag	caataaagac
28381	ctgggcttga	tgaggaggaa	gaccacgtta	taaggcaaaa	gttctccatg	aacttgaact
28441	ctataaagga	attgagtaga	cggaagccaa	aatattctgt	ttgttttttt	ttcttcctct
28501	gctcctctgc	agaacttagt	agagctctga	atgaatgtgc	ttcacttcct	aagctatcta
28561	tgaattgttt	caaccataag	acactactaa	ctgccctaga	taccagatac	aggccaatca
28621	accagagaag	agcaggagaa	ccctcctctc	aaggtgcaac	gaactgccaa	gccactgact
28681	cttacaatca	ggatggatga	caaacaccca	ggcaagaggc	atttggaacc	tgatccaaat
28741	gaatttttgt	ttcttgttgt	tctttaggct	taatgatcag	tctagatgaa	tactaccact
28801	gcaattagtt	acgtttattt	tttagcttcc	tttacacaca	catatgtgtt	tgtgtgtgcg
28861	cttctgtgga	gccatgtcag	caggcatgca	agtatcaagt	tttatgctgg	aaagaaagga
28921	gctgagaatg	tgcatgcccg	ctgaaggcat	atgtctcact	tggatcagtt	aagtgcctgc
28981	tccctaaagt	gaaatctcgt	tggaaatgcc	atgcacatgt	tgattcagtc	tgataagatt
29041	tcaaccaacc	ttctccttta	gctcgcaaaa	gttgcttcct	ttaaattaca	gaaatgccta
29101	acacaaaaca	acctcgtaat	actcaaaatt	cattatgatc	aaatgtgatt	gcttatacta
29161	agggataata	aagaaaatta	attttattaa	acacacgagg	ctctgttcaa	attaaatttg
29221	gtgctaatgg	ggaaaaaaat	caaaaggaag	aaagcagata	attatctgcc	tgagtaataa
29281	ccaaggatgc	tgcaagtggt	agtaacaact	ttggccagca	gttcttctga	ggagggttca
29341	ttcttccacc	aatagttttt	taattgaatt	gagcttggtg	gtggtgcctc	tcacattgag
29401	aagtcaccag	agatcaaaac	cagaaataaa	aagatgaaga	aaaatacggc	aaaggagaat
29461	gtttctgaat	ttgcttgcac	ataaaatctg	cataataaag	caggctccag	attgaaaagt
29521	ttgaaacaaa	gacaagatat	ttccatcagt	agccactgaa	aaaaattaga	aaatgcatca
29581	gtaggattct	gctttttgat	tagaaatagt	acctattttt	tctatatcca	ctccaaagac
29641	tttcactgtc	tatgttcaag	gatagtaccc	acaggcttct	tttttttgag	acggagtttt
29701	gctcctgttg	cccaggctgg	agtgcaatgg	tgcggatctt	ggctcactgc	aacctccgct
29761	tcccaggttc	aagccattct	cttgcctcag	cctcccgagt	agctgggact	acaggcgtgc
29821	accaccttgc	ctggctaatt	tttgtatttt	tagtagagac	ggggtttcac	catgttggcc
29881	aggctggttt	cagtcgaact	cctgacttca	agtgatgcct	gcctctggct	cccaatgttt
29941	gcgagtgagc	caccgtgcct	ggcctgtaca	tacagacttc	taagactcta	gttgagtttt
30001	acctgatttt	gaaatgtata	aaaatgaagt	cacagaagtt	aggacagcag	ttgcccttga
30061	gggcaaaggt	tggtgactaa	aactgacatc	agagggcttc	taggaagctg	gaaatgttgg
30121	cctctagatt	ggttttgtgg	atgtatccac	cttgcaaaat	tttatcaaat	cttatacttg
30181	ggttgtgtat	ttttctaaat	atatattata	ctttactaaa	ggtatatatt	cttctctatt
30241	tcatatggaa	aatagagatg	tagtttggct	taaaaaactc	agttttccat	aaaacaagga
30301	ttttgtttta	gtctaagtga	tgctctaaaa	tacaagacta	gagtgaggta	cttcccttgg
30361	atacaaaaag	ccaaaaactc	agtgattaag	ataaatagta	ttttaatgta	acatttttta
30421	aaaatccaaa	ttaatcctaa	aaaatccatg	ctagtaataa	taaagaaaga	ttaaaacaga
30481	aaatattact	catattactc	aggaaaacag	aaaatggaac	ttacactcca	aaaaatgcca
30541	ataagtgtaa	atgtgcagga	ataaatgtaa	atgtgcggga	ataatcagat	ttgagaaacc
30601	aagggcagat	tatttttcat	tccataagtt	tatattctct	gaaaataaaa	gacattagca
30661	ctgtttcaaa	gtttttaata	atttaggtaa	tttaaaaact	agcattaaag	gaacaatatc
30721	tgaattatcc	caacaaaatt	ctgaaacgaa	tatcatctct	atttgcttat	aatttcacta
30781	tgattaaact	tcttacgaag	ttacaagtat	gcgatcttcc	tttgaacgca	ctgagttagg
30841	aaaaacatgc	ctattgttgg	ttacacagag	gagagattac	aaatctaaat	catagttgaa
30901	aaaagcaact	gtgccatgat	atgaaacagc	actgtcaaat	cagacactga	agtcggtaag
30961	taagattttc	ttcttgtcag	taggaaaagc	actactgggt	ttgagtcccc	caatgctacc
31021	acctttttag	acttttgtta	gagctttgca	ttcatttcct	taatgttttt	aacccaatgt
31081	ctgtgaaatt	tttattgctc	cccggatggt	gacatctgat	ctgaatgtaa	ccatacacct
31141	ctttgctcag	cagtatttgt	cacaaaccat	tataaattat	catgctgatt	gtgtgcattg
31201	ctgggaaact	ggagaagttt	cataaattct	aactaccata	tcaatgacat	tcttgtttat
31261	tatacagata	taaactttta	tgagattcaa	gatgtctgcc	ttaccactga	agaaaacttt
31321	agtggagtaa	gatctaacta	gttcgatgta	catactgaaa	accattttca	atgtgcaatg
31381	aacatgtgtt	tccgaaaact	ctccactggt	cacttcttta	tttcttttct	atttttaatt
31441	atgctttgac	acttcacaag	tgtgcaggat	tttgctggca	aaaaagaaat	caacattcct
31501	tcctctccct	caacaccttc	ttcggtcaga	gcattctcta	gaatcctctc	aatctaataa
31561	taaaatcatg	catatatata	gctgggaaaa	aatcctagtt	ctgtgttagc	cctgcagaca
31621	gacgctccac	tggtctgttg	atcgactgat	ttacaccaca	tcttgttcaa	taaaagaatt
31681	aaggggttat	agtattatgg	ttctgatgct	tatttgtaat	gaaacctcat	tcagtgctgg
31741	catagacaca	gaatgttgca	tgttaaaact	atggaggcac	aacttacaca	tttaattttc
31801	ctaacgaagt	atccaccttt	gacagccact	gcaaaaactt	caccattttg	caaagtatga
31861	tccagaatta	actcatgaac	tgggtcagtc	ttggtgctat	tcacatgaga	agttgtgact
31921	gtatactgta	ttgttaagat	tatgaaatga	tgttttttac	ctaattatac	ataaaacaat
31981	aaaaatctaa	ataaaaaatt	tttttttttc	taccaggact	atgtagctgg	tctaatgact
32041	taaccatccc	tatactctac	aaaagaaaac	tgtttacttg	ggtttcaaag	atgtttcaca
32101	ataagcaaat	gtgctaaggc	atcgatttct	taagctttct	cagggtggaa	gttgactata
32161	caaatactga	ccatttcaag	agaaaatgca	gggtgtatca	tgtgcaaatc	atctcattac
32221	tgggtcaata	gatttagttt	tgacgtatgt	ttagtttcat	atttccaaat	gttctaaaaa
32281	tcaccaactt	gttaaagata	tcataataat	gataacttat	tttgagggtc	acttttacct
32341	tttaaaaagg	ctttcctatc	tactacttga	tcctactagt	aaccctatga	catcagcata
32401	gcaaatgttt	tttactgcca	acagacatat	aatgaagctg	gaacaaggaa	aaatattaaa
32461	tgtcttaaat	aagatgaata	gtttgttctt	aacaagagtg	ataactaaaa	gctcaccagc
32521	tttcagaatg	tggttttaac	tgtgcctagt	tttgtgccac	ctccaatcca	tttttgtaaa
32581	tagcctgata	taaagtacaa	aaaaacccta	ataacaaaac	tatgtttgta	ggaatctaat
32641	ctaaactttg	aagtctatga	atttgttctt	caaataattt	ctggtgttcc	caggtttttt
32701	ttttccccct	agggcattcc	aatcccctgt	aaaatttaaa	tctgtggatt	cttctcaaag
32761	ccttcacaaa	aggaggtaag	tattttgcca	catttgtaga	atctcaaatg	cacccttcaa
32821	cactgagcac	tagtcattca	tatgaatcag	cttagaaaga	tagtgaaagg	aatgccttat
32881	gctggtcttc	ctatatcttt	ctggagtttc	tcattgataa	aaagctcaca	atgcaacact
32941	tcaaaacaca	gcaggaagat	attttccatg	gatctaatct	ccattgactt	catcaggcta
33001	aatataacag	cctttcagct	ttggccagga	gatgRcacct	tcacagagag	caaagcctca
33061	gttgggacaa	ttaagaaatc	accttactct	gtagcattaa	aaaaacaaac	aaagtcacca
33121	ttattaagat	tgttatgtaa	catcttcttg	gccatgtcag	tttctcaaat	actttgctga
33181	tatcactaaa	actgtcattt	tctgtgaatt	acaatcatct	tttaatgtac	tttttaaaaa
33241	gaaaactaac	caaaaaggtg	ctcctttaat	cccattatac	cccacctgac	accatgatat
33301	gacaaatcat	tatttaaggt	ttactgtgag	ctagacacca	ttgtaatact	gtgagatgct
33361	gttgtaataa	ttagtatacg	ctgattattt	ggaaactgat	catcagccta	tggatttatg
33421	ctaattctct	aggcaccaaa	atgttgaatg	aaccagatga	ccttatttcc	ctgaccatga
33481	aaagctagtt	tactacacca	actcaacagg	ttgttgagcg	ctttctacag	gtaggaagat
33541	ttttatatta	ctctgttctt	tcccagaaga	aatgtatgtg	caaatagaat	tgtaagccct
33601	ttacatatat	taagtgattc	aactggcttc	ccttcttaaa	tttctactcc	agttgtgtgc
33661	tggatctggc	gcccaccagc	tcataagaac	caactgtgca	catttctttg	ctagtctggg
33721	cacagtgaca	tcacatggtt	agtttgaaat	tggctatgat	gagagtattt	acaccacaga
33781	aattggcatg	tgctacatac	aaatgaggac	ttgactcgtc	ttctccaaag	agccagctgt
33841	taaacattta	ccaccacatc	actgccaata	actagtgatt	attctgaatt	ctttaagtat
33901	tatattacac	gtattgatgg	tcatgatttc	cagattagaa	attagtaaac	gtcagtttat
33961	tgaattctaa	cagcacttta	ttttttggaa	taatgttatt	acttgagtat	gttttaccag
34021	agtttctcct	atagcagttt	aaacatggtc	aaaaagcaaa	tactaataac	tactgctact
34081	actaatgaag	taaatcaaat	ataaaagaaa	acaagtctcc	agattgtcta	ggtgattgac
34141	actgtaaaaa	ccaccataaa	gaatattagc	aaaaataaat	aaatcaatac	aatgaactct
34201	ttgtttccaa	gcagtcactg	gaacactatt	aatggtaact	tccatacaca	attaaaaagt
34261	caatataatg	ccctgaggca	cttctgaatc	acaaagcaaa	gataaattgg	aattggtgta
34321	attttgttgc	actgtagtat	acactgatta	tttggaaact	ggtcatcagc	ctgtggattt
34381	atgctaattc	tctagatact	aaaatgttga	atgaaccaaa	tgacctcatc	tctctgacca
34441	tgaaaagcta	gtttactaaa	ccaactcaac	aggttgtcga	gcacttccta	caggtaggaa
34501	gattttgata	ttactctgtt	ctttcccaaa	agaaatgtgt	gttcaaatag	actgtcttta
34561	acaatgaata	tacttgcaaa	ataatattta	ggtccagcgg	tagcagtagt	ctgtagatat
34621	catatacggt	tacaccaaac	tgacccactt	taaaacttgt	gaaaacctct	cagtccctga
34681	gaaacacttt	agaattgaga	tttaaatcga	ttatttttct	ttgataaaac	tatttatata
34741	tgtacaaact	taaaagatgg	atattcaggt	tcaagtctct	ggagactaca	ccactttcag
34801	tgggtcagaa	tgggataatg	tggacaagac	agagacaggg	ggtctgttgg	gtgttaagag
34861	agacgagcaa	acatgtatct	gagtggactg	ctacgtgcaa	ggtaaaaaca	tactttcgat
34921	actgtggaaa	gcaatatcca	cataccagtt	ctttcacata	aagtgaggaa	atataatttc
34981	gactgtctct	atagtgagaa	tgtcttcata	ataacgaaat	tgggcataag	ttgatgttta
35041	gaaacttaac	aatagaaaga	gatagcaaga	ctaagcaggt	ggatgaaaca	ctgatgtgta
35101	tttgagttcc	cattgtattc	atcgtgtctt	aacaattatt	ttctagcatt	ttccataaaa
35161	gtattttaat	cagtaatcca	ccatttacaa	aacccctcat	ctggcttatc	ctgtaggcct
35221	tattttattc	aatttgcttt	ttccatgtca	aacttactta	gtaagatgaa	tgcagttctt
35281	aaatcataag	atgtgccaca	gttcaatata	tctcaaatag	tgagatctcc	aatcacacta
35341	tctgtggatg	cgatgtatat	tagtgatcca	ctgtatttcg	taaaaataca	agtgagattt
35401	ttgagtttct	agttcttccc	ctctccagga	aaaaaaaaaa	aagaaagaaa	aaagaaacat
35461	acatactgta	tacatttctt	aacaagagtt	cccaaaccaa	aagtgctaac	aggaaggagt
35521	ataagagctt	acacatttaa	ctataatctt	cctggtttgg	ggaactcaga	aatcacttaa
35581	cgtacttcaa	tttccatacc	attgacatat	aatctggctg	agattggaat	ccctcctgga
35641	tccatttata	atctacattg	tacacacYga	cttccccccc	gtagacaggc	gtgaccacta
35701	gatggtgctg	tggtgccctg	ttcaaaaaca	ttcccactta	cttgcagtct	ctgtcctcca
35761	aatcgaagtg	agggttgaag	ttgatcataa	ttctctggta	tgggtccgga	gcctgaatca
35821	gccattcgca	tttttcactt	gggtgataag	aatgaggata	accaggagat	gtaaggtacc
35881	cggggctttc	aatttttata	gtatcgccac	atttatctgc	aatgaaagta	agattttagc
35941	agatctttcc	tgacaacctg	ttaggtaatc	tagctttata	tgtaaattac	tggttattaa
36001	acattcctta	actttttaag	gggaactcta	aaaggtcccc	gtaagtcctt	cgtgtggctc
36061	tgagtgcaac	actccaggaa	aaaacactct	ttgatctcag	gaaggttgac	tcaggcagaa
36121	agccaactga	gatctgagag	gactcttccc	cccagccccg	aagtttcttc	ctaaggaaaa
36181	ggtcttctag	cattaaaaac	attaaatccc	ctcaattgat	gttaacatgg	tcccctggga
36241	gcttctgcta	gacttaatta	tcccccaaga	agtgtaatca	cattaagtag	caagttctaa
36301	gtggaaagtg	actgaaagat	gctgttcgac	cccttgtgtt	gttttttgat	gataagcctg
36361	gtctatgtca	ttgatcagtg	gggattgtct	ttgattggct	taaagccaaa	ccttttgttg
36421	ttgttgtttt	atctgcccat	aaatctaagt	gattttgagt	tatctctgct	cttgagatcc
36481	aaatcaacag	agaacaaagt	atatttggtg	aagcagaaat	aattctgctt	tacttctcca
36541	agtaaagttg	ttcaagcttg	gagatcggat	caaagcaacg	gggcagaagg	aaaagtaaat
36601	agccacatgg	cattaattct	aattacctaa	atgttgggtg	aaaaataacc	caccacacag
36661	gtctgggtat	cacatatggt	aacccacatt	ctcacattct	gggaaaggtg	agctaagtag
36721	ttttgagcct	tcatttcaaa	aatgctcaag	tgaagccaaa	taaaccaagt	aaaccagtct
36781	ctgggctgcc	tatattgttc	agcatagatt	ctcattgtca	cattttatga	tggatttcat
36841	actggagcac	ctcagcctga	aatgctgcca	catttattga	tgcttaattt	tgagcaataa
36901	aaattcggtg	cataaactat	ataagagaaa	cggtatgaaa	acagtgaaat	atataagcct
36961	atcaatcaca	aattttcagt	aatggtagat	gtagatttta	acactgcatc	taatagattc
37021	cctgtggaaa	gagaatggca	ttctttgctc	tcagcatgaa	tttataaatc	tacagaattt
37081	tattacagga	aaaccaggtc	aaatggaaat	gaaagatgaa	gtgcacatca	aaaatgcata
37141	aagctacatg	cattacagaa	atcatttccc	ataaattaaa	aaaagaagac	aatataagtt
37201	atattgtttt	tctcaatcgc	taggtgcttc	tgactttgtt	ccttagactg	ggggtagtct
37261	tatgctggtt	tcctttgcac	tggcttgtaa	aagtgtaagc	tttgccagga	agaaatgatg
37321	ttgcaactgg	agttcaaaat	ctcagctaat	gatcatgttg	gactctgtta	tgtgattctg
37381	ctgagactct	tgcattattt	tgaatgtgca	gaaaacttgg	aaagtgacct	cgtctcatta
37441	agtttcctct	agctctggac	aaacatcatg	gtagtgtctg	gcatctgtta	caggagtgaa
37501	ataaaacagc	actggttcta	gtcactcgac	agagtcactt	cagaagacat	ttaggtggac
37561	ttggtaccac	accagagctc	tttaatctgt	gacttctgag	aaagtgacag	tgtaataaga
37621	taatgtggac	tgctagactc	cctggctctg	ttcaatctct	ctagcagttg	attaagaaag
37681	agcagtttct	aatgactctg	gaccattagt	cctaaataag	gttaatgaat	taatttagca
37741	gacactggtt	actcagagga	ggtggacatg	gctttgagag	gtctgctgag	ttacagaggc
37801	attttctggc	tctggtcact	tcaagcatag	cgacatggct	tttgctggta	aagctcaaca
37861	actaaagcca	gattttcagc	attccccaga	tttctgctaa	gaaaactaag	aagtgtgtgt
37921	gtgtgtgtgt	gtactgcata	tatatttgtg	tagttcacaa	cctaaagtct	gatagctctt
37981	tgcattgagc	ttcaaatcta	tcttgtgaac	acccccacta	tggatttagt	ctcaagagtt
38041	gtggaggaca	gggttactat	aatttctagt	ccaaccattt	gagctctttc	agttggacga
38101	gaatgctatt	tcattccctg	ccagagtata	gaaagatgct	accagctcag	gttcattaat
38161	aaattgaatt	ctacattcat	aattttttgt	gtcttgcttt	cctgccagat	tatagaaaaa
38221	tgccatcaac	ttgggctcat	taataagctg	aattccatgt	tcataatttt	ttttttNgca
38281	tgtgttttgc	tttaagcatc	tcttaaaata	ctgcttggta	gctgctgagg	gaaatccatt
38341	gctaaaatca	caaaaccttg	aaaaagcata	ttagagagat	taacttccat	cataaagatg
38401	tgatttaaat	tcctgttggt	atgaggccct	ccacttgcgg	tctcttatta	aaacaatata
38461	ccacagtaag	tagtggatgt	tcttttcttc	taattactgt	gattgaaatc	taagccagac
38521	aaaagtaaat	atttgatcat	tagttaataa	caattgctga	cgacttactg	taaagataat
38581	tgcataccct	tgcctgcact	tactttacag	tgtgaagtca	aacatgccta	caaccagatc
38641	ccattttaaa	acacattatt	taggttacat	ggtactgttt	agaccccagt	atagtttttc
38701	atttacttaa	cagtgagtga	ttttaaaagc	taagtggaag	ctgcaactag	cttagggatt
38761	ttcagatatc	ctggtgcctt	acactgtata	tgtcagattc	ctgtattgat	actatgtaac
38821	tttcagtcat	actccagaca	gattacggaa	ggtgtacaaa	ggcgggggag	ggagtttcat
38881	caacccacaa	accgatatct	ctggccgtca	cccaccagag	gaaacggctt	aggggagcag
38941	caaaggaacc	aggaagtaag	atctcctggt	aaagtgttca	ttaactttca	acagccatca
39001	gatttttgaa	agggagtctc	ttctaattgc	ctttgggagg	aaacattatt	aagataattg
39061	gcatgctgat	ctgggaaggt	agacagctct	gtcttgtaac	agaggtaagg	aaaagcccca
39121	cagcccaagg	atcaacgtca	ggagggagcc	caaagacctg	aaatcctcct	gctctaaacc
39181	gcctgatctc	atttcttctt	ctctcctccc	agataaaagt	ttccttcgcc	cgggagtcgg
39241	ttgttcccgg	ctgatcccgg	gaagccccgc	ctgagccccg	gtccggggcg	ggcagctggg
39301	agccggggcg	ccgctgtcac	ccgcgcctct	gcctgtcact	taccgttgcg	aaaagcgccg
39361	gccggggcga	ggacgagggc	gagcacggcg	cagaggagcg	gcagccccct	ctccattctc
39421	ccttctccgg	gtccgcaggc	agacgcggga	gaacgaggac	gtggggggaa	atgcagcaaa
39481	gaggagaatc	taagcgatcc	gaagagcccc	aactccgcct	agagctgtac	aatcctcagc
39541	ccgtcttgga	gaaaagaaag	cagcgaggca	atgcctggat	ccgagaggaa	cgcttctctt
39601	tttgtgtctc	aagtcgcctg	catcctgtca	tttagctccg	gcttcctctc	ccttttccca
39661	cacttgttcc	tcttccagga	gccactgccc	gggccatgtc	tcaaaaaaaa	aaaaaaaaaa
39721	aaaaaaggcc	gggggggggc	tgtgggtggg	agggggagga	gggaggtagg	gcaacacaca
39781	ccaaagccaa	tttccaggaa	gaaaaaaaaa	aaatccggct	tgtttctgga	cccgttggag
39841	ccgcggagct	ggcgcccagg	ggaggtccgg	gtgtctgcgg	gaaggagggg	aacgagcaat
39901	gaaaagatga	gcgggagaca	gaggagtttc	accaactgca	cccccgcctc	ccctcctgcg
39961	gcctcccccc	actccggagc	ccttccctcg	cttcctcccg	cccctctccc	cgcttgggct
40021	cgcctgtaat	tgcctgacag	gagactggga	ggaacaactt	tccctccgag	tgctctcccc
40081	gtccgtctgt	ctgtctttcc	cagagaccct	gcagggatct	ccgcgggaag	gaaggcgctg
40141	ggagtctgcg	ccccggtcgc	gtgggtgcgg	gcgtcggagg	aaggggcgcg	gaggtcagtg
40201	ccagccgcag	ggtctggcca	gcccacctcg	cgtgctcgct	ctgcacccct	agagggagag
40261	ctgggcagct	cctgcaggcg	cagatcccgc	cgccgcgcag	tgcggagcgc	ccgggaggtg
40321	gcggctgctt	ctcgcaactt	caaatcccgg	ggcccgcgcc	ctcggcggcg	aggaacgcag
40381	ggtcaccccc	tgccactcct	catcgcgcca	tcctgagacc	tgtggcgggg	agcagcgggg
40441	cacccctgga	cgcccctgcc	cagagctgga	gggcgaggag	gggaaagccg	ggctggagtg
40501	ggagccgcac	cgcgaagccg	ggcgaggggc	agcagtgtcg	ctgtggtgtg	aagcgaagac
40561	agaccgcctg	ggcgggcgag	gccgggctgc	agccccacgc	ggcctccctg	gcccgcatca
40621	gggcgcgcgg	ctgggtgccc	tctgcgcgcc	gcggaggctt	cattgtttcc	cgagatttgg
40681	tgcccgttcc	tctggggcag	agggaacacc	ggagggtggg	aggtgctgcg	ccttccaagc
40741	aggggggcaa	tcgccgcccg	accccgccca	accttgtctg	ggagcccagg	tgctagggag
40801	gggtgtggaa	atcaggggtc	gggcggcccc	cgtttctctg	tgcatcccga	gggagggaaa
40861	gagtggcggg	ggaggggtgc	tcttcgctgc	gccctctcag	tgtccgctcc	cggccacaga
40921	caacgtgcac	gccggccctg	gagctcctgc	cacccccact	tcccacagcg	gctcgtgccc
40981	ccagcccgct	ggatgccccc	caggcccgtc	cccgagggtt	ttccgagaag	tgctgcagga
41041	agcgtttgta	gatgcgaaaa	gcaaggacat	ttctgggaag	aaacaggttg	cggtcaccga
41101	tcaggccccg	gagaagggtc	agtgcccacg	gggcacctcc	cagggagttt	gtgggtaagg
41161	tgaaaaggtc	acacgcctcc	tggggattgg	cgtctacaca	cacagccaaa	gtacagcctg
41221	attcctacct	ggcacaaata	gctggccaaa	gggaggtagg	aatgctggca	aggagactct
41281	ggtcaaaggt	tttggcggaa	gaaaaagggg	cgggcaggga	gaaagcccaa	ggcgcgcggg
41341	ccccaggcca	ggactgcgcg	ctcgcgactc	gggctgggag	cagtgacgtg	cgcccctcgg
41401	ggtgcaggcc	gttcccgggc	cagtgggagg	tgcacccacg	gagcccgcac	tcgccactct
41461	cttgccccgg	gtcaagcctg	tcttctcctc	cccacgcgcc	tcgggattcc	cagtcgccaa
41521	gttggaaact	cggccccccc	gagcgcctct	ttcctctgcc	agtttcctcc	ttcttctcag
41581	ctgtcggacc	cctgggaggc	gcggggtggg	aagtgggcac	cgaagggctg	ggagttaaat
41641	gcctaagttg	agcggaagga	gcactgtcga	agccatgggc	agccctgcgc	ccgggcaggc
41701	gggcaggcgg	gaggcgaggc	gggggcgccg	accgcgccca	gcgcagaccc	cgggggagtg
41761	agcgccgcag	aggcagcctg	ggctctcggc	tactacccgc	gcgcggtcgc	cgcctcccca
41821	ggtgcagccc	cgccagtccc	agcccccggc	tgcgccgggc	gagcggcatc	atcagattta
41881	gggtgacccg	gagcgacctc	ggtccaggct	cggagggaga	ggcgcctctc	aggacctggc
41941	aggttgacag	ggaaggggaa	ccgggaggga	gcggcggccg	gggcggcctg	gagtctcgga
42001	ggcccgcctg	cgtcctgggg	ggacccgacc	tccgcgctcg	ctccggagcg	cccgtttgga
42061	tagctctgag	cctcggcggg	gtgagcgagg	gggcacacga	gggagacttg	agctgtgttg
42121	tttttagaaa	actgccgcca	atctctcttc	ccctttccct	gctgagtgtg	cattttccag
42181	cctagacccg	ccaggccagc	aaataaagcc	accggatcgt	gcactccgga	gcgactgccc
42241	ccaccccgac	cttgtctttc	ccgaagggaa	tggctcctcc	ggcgcctcaa	cgcacagaaa
42301	acgcctgcct	ccagctgagc	gcttttgcca	gctttctcca	accagtgaat	aagggatgca
42361	ctatggactc	agaaggaaat	gtcatattta	agttctgcct	ctgatttctc	tgctcttagc
42421	tgatctaagg	tttttctaga	ctccttagtt	tccactcaca	gtgctgggta	atggagccct
42481	accgcactga	ttgagaattg	ccggccagtg	ggttggtaca	gagcaaattg	tccttgctaa
42541	caaccttttt	cctttgctgt	tggattccac	taagtggtga	gaggggtcag	ttttagattt
42601	ttgcaattcc	ccagcgtgga	gacaggccgg	ctctatacga	gaataagtga	taggcagagg
42661	aagaatttgg	cagtgttccc	gggttgattt	tattttggtc	tcttgaacac	attattcttc
42721	ctgatagaac	aaatccctgg	acttggtagg	acccagttcc	agggaaggga	agagtcctct
42781	accgcacccc	cagaacgccc	tgcagaggct	gtgagtgggc	aaagcccagt	ttcctggact
42841	cccacttagg	aggtgctgca	gaaataaggc	cttcagctgg	ggctccctga	gtcggattgg
42901	aaccgtggcc	catcagtaag	agtagactgg	atggtaactg	ctcgattcct	ttcatcaagc
42961	tctcatccct	ttgtcagaaa	tagatgaaat	cgattgctcc	cagaaggcca	tttgagccac
43021	taactccctc	aaagtacttc	agattcatgc	aatatggaga	ttcgggttgg	tagttcaaac
43081	tgcatcatat	ctagtcaagt	tttttgaaaa	catcaaaccc	ataaatttca	gaaaagcaat
43141	acaagctcca	tatttttagt	aggagctaac	ctagttttga	gatgtatgaa	tagatgaagt
43201	gaaactggaa	aaacattaaa	agttggaatt	ttaattaact	aatgtttaaa	ataagcctat
43261	tagtggttat	tctgtcaagt	gactgtgtca	tgcaagaggt	gtcatctggg	cctcattttt
43321	ggccatctcc	ttgatttgta	ctgacagaga	aggaaggaaa	taaacaaatg	aatcttcact
43381	ttctgattct	acctttttag	ccttttaaaa	gttaccttga	aaattcctca	aatattggag
43441	aaacgactac	caactaaaac	gttaacacaa	agttacaatg	tgaagttttt	gtgatacagt
43501	atatttacta	accaacaaga	tgaagaaaga	taatgctaaa	ttttgaatca	cactagattc
43561	aaaacatttg	ctagagtaga	ggttacagcc	atatttgaaa	actgtattat	ttttctgaga
43621	taataatatt	aaatgatttt	gccttcattg	gattactttt	aaattgggaa	aattaaaata
43681	attataacca	acagaaacac	tcttcaaatc	aatagagaca	tcattagaga	gaacatattc
43741	aaaatttgaa	aggactgttt	taaatagggc	aatctttaaa	atataatttg	aacaaccaga
43801	atagaaaact	ggctgcctct	taatatttaa	tcatagtttt	atgtaaatag	ctaaaatttt
43861	aaatcaataa	aaaataattt	ttaaaaatat	caaacaatgg	ccacaacagt	taagaattgt
43921	tgaatttatt	ctcaaaggat	gtaatttcat	tttgcatttt	tattagatga	ctctggcagt
43981	tgcctgtaga	atgggttatg	ggcggagcaa	gggaagaaat	gaagagacca	gttttgaagt
44041	aaccatagta	gaatctaaag	gagaacttca	acaaggatct	ggcggtggag	attggaaaag
44101	gatgctttcc	agatgtattg	agaaagtcca	actggacaga	tggtggtgga	taagccaatg
44161	aaggagaggg	tgttaccaaa	gattcaggcc	ctcatcactg	atgggtgcga	ttgccttcat
44221	gtaagcaaag	ggacactagc	aaaaggctaa	tttggaagga	agatcatgaa	tttgattggg
44281	gttaggtaca	gtttctggtg	tctttgaggc	aatcaaatga	gttaggaatt	cagaggagat
44341	gtttggattg	gagattttaa	gtttgtgagt	cactgacatg	tagatgatgg	caatcaaagt
44401	ggaaggaatg	gataaaattg	ctgaggaaat	ttcaggagac	ccaggatagg	aagttaagga
44461	ccctttaaag	cctggattgt	cacagtgagc	taacaaaata	ccttgagaat	gagcagctgg
44521	gtggtaggtg	gaaaaccagg	agagcctatt	gtcataaaag	tcaaggagag	ggggaatttc
44581	taaaaggaag	ctctggacaa	gagtggaaca	ccatcaagag	ttccactcgg	atgaggactg
44641	gaatgcaatt	ggacttagtg	gtatcatggt	tactgagaat	tgactcttcc	aagagtcatt
44701	cagtggagcg	atggaggaac	aggactagag	gtcagattgc	aatgggctga	agagtcaata
44761	gaaggtaaag	aaagagagag	aacacataaa	gataaaattc	tctctggaag	tttctactaa
44821	aggggaggag	acagacgata	gctctggaag	gaggagatgt	ggagggaggt	tgacttttta
44881	ttttatttta	tgtttgcttt	taagataggg	tacttgtgaa	cattcttgaa	tgccaatgga
44941	tagaatccag	tattggggga	tatgttgaga	ttaaactact	gaaaagataa	tccgggtgtt
45001	gattgcctgg	gaaggcagga	agggatacaa	tctacagccc	agatggacag	atttaccgta
45061	agttggaaga	gggacagctc	ctctgttata	gcagtgggga	aagaggagct	gatgggtgtg
45121	attacaagaa	ggtttgtcat	ttcagtgggt	gggtgtgggg	ggcaatttct	ctctactctg
45181	gttttctctg	tgaagtaagt	cgtacctttg	agtaagaatg	acagtggagg	agaggagccg
45241	aaagtgcctg	gagagcagaa	aaaaattgac	ggggacgact	aagctgacca	gagaagctgt
45301	tgttatcatg	ttattgtttt	gataatttcg	taagttaaaa	atttgagctg	ggagcacatt
45361	ttctatggaa	ggcattctcc	tagaaaaatt	ggctagtttt	tcatgaaact	caaaaaaatc
45421	tgcttaactc	acaaggaagt	agtaatataa	tatgaatggt	attctttcag	ctttagtgac
45481	tcaaagtagg	tgttctataa	atgttctttt	ttaaaaagaa	aattttccaa	ccattattta
45541	cagcacatta	aggaatgtgt	ctattgatgg	gtaggaaaag	tttcccccca	accaaataat
45601	tctttgtaat	aatgtcttca	cttcctccct	gccctttgtg	ctttatcctc	ctagagatag
45661	ccaaagaaga	atttaaagtt	atcatttatg	tcctgtacca	gacctccaca	gactggctta
45721	tttggataat	tcaagtgaaa	tacaaccaag	atgtttcttt	agttttgcga	agtctagact
45781	caacatcaat	attgcacaca	tttttcagat	atatatgtga	tgttttttga	attgttatac
45841	aatttcctgc	cttgatattt	cagtcaaatg	tattgggtag	gttatcagag	ggcgttgttt
45901	tcaaaaaaag	cctttttcct	tcaatttatt	ttgttaaagc	atcagactgc	caaagaatct
45961	taacttctat	gtaaggggtg	atacattaat	acctttttgg	ttgattttca	gctacagaat
46021	gcacagcctt	gatggacttg	ctttaatcca	cactaaagct	tatatgacat	gaggaagtca
46081	tgcagaacag	aacaggcctt	tctggaactt	ttatatttta	agaagtcttc	agcctgttag
46141	tacaacaggt	taccttttgg	caggcacatt	ttcctcctgc	tcgaatgcta	taaacacccc
46201	agcagggacg	ataaatagca	atgtagacag	caagggaaaa	tatttgctaa	aagatactcc
46261	tgcactttct	ctttttgatg	tttcccttgt	aagttttagt	tgaagaaact	ggaaaaaata
46321	gaaatgtaaa	agttgaaaca	gcaaaattat	aaagtgacag	gtgatacaac	aaaacatatc
46381	agtttgtact	caaaatgtaa	agcaataaag	caagcacaca	ttgagactct	ctaattagta
46441	taatttgcat	tcacaaagtt	caaagtggaa	cttgggtatt	gccattctct	tgcttctctc
46501	cctaacaagc	cacaggtagc	cgaaatgagg	cacattgaga	gttcaaattt	ggcaaaactc
46561	tgcagcaatt	cagtgacaga	ataaaacatg	ggaaatggat	gttttgaaat	tgagtctgta
46621	tcttaaagaa	agtgaaagta	aaactttata	ataaaataag	gctaaatcat	acacaattag
46681	tgtatccttt	tgaaaattag	tttgtgtttt	ataaggtcaa	atggcttctt	taaattcata
46741	ctgtgctatt	gtatctagcc	tggcatgttt	ctttactgta	gttctttttc	tgaattttta
46801	aacccctttg	tgatttcaca	gagttagtaa	ttatgttggg	atgttggggc	gtggactgga
46861	tgtagctaaa	catactcaga	tttgactcac	attcaaatgt	actcaaacat	tcaaatttaa
46921	agttgtctgc	caaagcaaac	ttctgtctca	ttgattttta	aaattctctg	gaccttggtt
46981	tgaaaatgtg	ttctttgggt	ttcaaaacag	ttatctgtct	tagatagatc	aactctgaca
47041	tctacatatt	tgacactagt	tctgattatg	tcaagtgcat	atcttttatt	atgtagataa
47101	aagacaacaa	cttgcatgtc	acgtaaaaga	ggaagcatct	cttcaggtcc	cgggtacatg
47161	agtgagtggt	gatcctggtt	tttcagttgc	atatcaagaa	acacaaccta	gatgagctta
47221	atgaaaaagg	agattagtgg	tcataacagg	gaaactttgg	agtgaacttg	gcttcaggca
47281	tagctggaac	caacggttca	gtggatgcca	atcagcaggg	tgtcttctgt	gttttcatct
47341	gagctggctt	ctttctcaag	caagaactcc	ccaggcagtg	tcaaagatag	taatgacagc
47401	tccgtagtta	aggggccctt	caaggtcatg	atcactgaga	aagtgttcag	gcagagggtg
47461	ctttctccct	cagagtatgt	aattatcatt	aataaaattc	tgattcactc	cagttggatg
47521	atgtacccat	ccctgggcca	gttagttgtc	aagggagacg	ggttactctt	aagcccaccc
47581	tggctgtggg	catgagaaca	catggtagac	agaatgcaga	caggccatct	ccaagaggaa
47641	aagggagtct	ctggattctg	tgatacaaat	aaagggaaaa	ggacgccagg	cagtcagcgg
47701	aaacaggtgc	ccaccactcg	gcagcccatt	ctcttggtta	tagttagttg	ttttcaagtg
47761	atagtacagt	tgactcttga	acaatatggg	ggctaggggt	cccgacccct	cccctgcaca
47821	gttgaaaatt	cacatataat	ttttgactcc	cctaaaactt	agctagtaat	agctcactgt
47881	tggtcagaag	ccttcccaat	aacatagtca	actaacccat	atcgtgtaca	tgtattatat
47941	gctgtgttct	tacaatgaag	taagctagag	aaaagaaaat	gttattaaga	aaatcagaag
48001	gaggagaaag	tacgtctact	attcgtgaag	tggaagtgga	ttatcgtaaa	ggtcttcatc
48061	ctcatcatct	gcataaggag	tagattgagg	aaggaggagg	aagaggaggg	gttggtcttg
48121	ctgtctcagg	agtggcagag	gcagaagaaa	atctgtaaag	aagtgaactt	gcagagttct
48181	aacctgtgtt	gttcaagggt	cagctgtaca	tgttcttagt	ttttgttttg	gttggtgtta
48241	gtgtcgtgtt	tgttttattt	tgctttgctt	tcagtttttt	atttgaatat	ccagctgtgg
48301	cagacagcat	gaatctatag	attttacttc	aaaatctgag	gccagtactg	tatgcagggc
48361	cagctgtcag	taaaattata	aagcaggaag	agcttttgtt	tgttttttga	gacagagtct
48421	cagtctgtcc	ccaagctgga	gtggagtggt	gcaatctcaa	gtcactgcaa	cctccacctc
48481	ccgagttcaa	gtgattctca	tgcctcagcc	tcccgagtag	ctgggattac	aggttcccac
48541	caccatgccc	agctaatttt	tgtattttta	gtagagatgg	gggtctcacc	atgttggcca
48601	ggctggtttc	gaactcctga	cctcaagtga	cccgcctgcc	tcagcctccc	agagtgctag
48661	gattacaggc	atgaaccgct	gtatacggcc	aagaggagtt	catttttaac	tccatctcct
48721	tttgggtgta	tgtccctaat	ttaattcgct	cttccctgtc	ctctcacaag	gacttccaaa
48781	gaaatagagc	agtggcagaa	cacaatactt	aactcataga	atggtgagat	tgcaggcacc
48841	actgttagcc	aggtgaggaa	ggtttttgga	ggcaaggaac	cttccaaaat	atcttcataa
48901	ggatgtaagg	aacctatgca	tacttggagt	tggagtgtac	tgctgtgttc	agacatttaa
48961	agctgccttt	gtaaaggaaa	tgagattata	tttactctgg	ggagattgcc	atgaagacag
49021	tgcttgagaa	gcacctttaa	aatatgaagt	tttcctcaac	aaatgcaaca	tttttaaggg
49081	gctacgactg	gtggactaca	ggtgtgaaaa	gtgtgcagta	taacagcaat	agcatcataa
49141	atggaaaagc	ttggaacaga	ctgttcttct	gcagagcata	tcttgtgtgg	tgtgtttttt
49201	tcgaggtatg	ttaagagtct	tggaacaaaa	gaattacttg	actatattga	gatgtatctg
49261	gaacaggccc	acacacgtct	gtggtgccag	tttattcttt	tacaaaatgt	tacctttaaa
49321	aaaaattttt	aaatacacac	ttaaatgggg	atgggagcac	tgtcagggag	agtctcacct
49381	atgaaagcaa	aaagcacagc	ttaatttcag	agcactgcac	tgggagtcca	gtctccgctc
49441	tccacaactc	tcagagaaat	tctgaacaca	gcactttgtc	atattttcca	ctaatttgtt
49501	cccaaggtct	ctctccggag	agcgtctaca	aactcaaccc	ctgccctgaa	ggggctgtgg
49561	aggaagtggg	caaggttgtc	tacagtgtga	ctttcttggg	atacttcttc	atcctggggg
49621	aaggcctaat	gtctaagtga	ccacctgtga	gcaggtgttt	ctctcacagg	gatccgtttc
49681	tacgagcaga	cacccttgtg	gctcttgttt	gatctgtgtt	cagtttattc	ctaccaagat
49741	agctactctc	taggaaagcc	tggatcggtt	tcctctctag	gagaccccag	aaggaggttg
49801	ggttcaggta	tgtcaggcag	gggagacaca	aaggaggcaa	ctcaacaaag	cacatgaaac
49861	agcagaggat	gtgtattact	cacaggtccc	agagaggaag	ggagcaggac	tcatagggcc
49921	agctggaagt	ggggaactgt	ctgagacaca	cacatgcaac	cagggagtgg	ggagcaagag
49981	agagagttgt	aggggggacc	tgtgggccaa	agcccttact	agggtctagg	gcattaccca
50041	agtaggcttc	ccatgggaag	ttctaatcgg	tgggtgagct	ctgtggagac	tgcaactgag
50101	agggggtcac	tgcagcatat	ctgtgtgttc	tatgttggtg	ggggagttgt	tggggcagtc
50161	agtggggcca	gtcaagtagg	ttgtatccag	ctctccctta	gggaggtggt	caccagcaag
50221	tggttgtcaa	ccaccttgag	ttactgggag	gaagcagaga	gcagaagact	atgtcaaaga
50281	tgactaagcc	ctgctccccg	tatgagaaag	tcaagcctag	attcaggacc	gatgccagag
50341	caacataaaa	ctatagaact	cactacatgc	ttcatgcagc	tcggtttcca	gtgtttccat
50401	ctgtaagaga	caagtattga	attaagtgat	gtatcaggac	cttatcagtt	gccaaattga
50461	atcattctac	tgtttttttc	agcagctttg	ataaaacatt	agtgcaggct	tgtcattacc
50521	caatactact	ggaggccttg	aaagtgtgga	gtgctgtact	aggatggcac	atgacgtgac
50581	ttatgctgac	attgactcct	atgctgacat	tgactccttt	gcacagctga	tatttgaaac
50641	gctcttggta	tattttcttt	ctgaattgtt	tgtgttccta	acatgggcca	tgaatctctg
50701	aagtggacat	ggataccatg	tcctatgtct	acctgtacat	attgtcagct	tgcaataaga
50761	aatatgataa	taaaatgaag	ttctatcaga	ggagtggcag	gggatgatca	aaccacaaag
50821	aaaacaaagc	aaggaaacag	cacaacgcaa	acacagacac	ccctcaccaa	aactcttctc
50881	tgcctgattg	ctctaaaaca	caaggcaagt	caatattcct	gttcagctga	gaacaagagt
50941	gtttacttca	tggaagatct	ttgagagtta	gctaaattaa	aaatttaagg	aaaaaggctt
51001	atcaagaaaa	tatgagtcaa	aatgtggctg	ttccttttta	tgtttctccg	atttcgtgct
51061	attttgctac	tggaaatttt	ctgcctctct	ggatactctt	gcaaatggga	acagatacgc
51121	ctagcctggg	ttcctgctcc	atcattcccc	cagttctagg	agcaggagcg	gagcaccact
51181	ggtgctaggt	caagtggaag	acaaatgatg	ccacattttt	gctgtggatt	ttcttttatg
51241	tcgtctctag	cttctggacc	agcggtatat	tatttttcag	agtctttttc	agatcaattc
51301	tgagcttaat	tgctgacttg	cttgtgaggt	tggaagctct	acctacagtg	taccatgctt
51361	ttgatagaga	aggtttctgg	gcagtttttg	gtttttcata	gaggtattgg	ataggctcat
51421	actgattaag	ctgtggctcc	agcaaacatg	ctcaatatta	tgaagtccag	gaggtaggtt
51481	ttgttgctaa	cataaaaata	ttcttcagct	ccacgctggc	ccaaagcagg	agggggaagt
51541	tggagaggaa	cttcttcatc	catcaaacaa	agtgtatatt	tgttgccgtt	ttgacaatca
51601	catcccttag	taaaagatgt	acttgaaaaa	caatataaat	aaaataaagt	ttcataaagg
51661	ctcccaaaca	ttcttccttt	ccccctgagg	ctataatgac	tatcctggtt	ttaaaatccc
51721	ttttcttatt	ccttctgagt	tttcccattt	cgtgctccct	gggagcatct	ctgtaaaata
51781	agcctgtgga	aaatgggtaa	tgaggaaatc	gttgccttaa	ttgaaggtcg	catctacaaa
51841	ggtccaggta	ggtgcacttt	ggctgatgga	aaaatccccc	agagtgacat	cctgctgccc
51901	tgaaatagag	gctcggttgt	catttgttag	aacaacggtg	gcgcctggtt	ggcatctcga
51961	gtgttgtctt	tgttaatctc	acaaccaggt	gatttccatt	actgacgaca	ccccacatgg
52021	gaagggggca	aggaagggcc	cccaaggact	cccataatta	agcacaaaca	cttttacagt
52081	attaagtcaa	agccgaatgc	ctcccaaatc	ctcttggtgt	tgagttcgtg	tgccctacac
52141	aatggtgacc	tttaatatgt	ccctttcaga	tccagctaga	ttagtcctgt	gctctggcct
52201	tgatattttt	tgttttgttt	tctagtgcta	ttcctttaaa	agaagaacta	tgagagtgat
52261	ttttttaatc	tgtttgctta	cttttctttt	ctttttttgg	cttattgtca	acatgttgtg
52321	ttgacacact	ttttagccta	aaacagagag	aggaccttct	aaatacaaaa	gataggatgc
52381	tttcaacaac	tcgattccct	aaagcactgg	agaattctgc	gatctgttag	acttcaatgt
52441	aagcatttta	tagaggttcc	catgacagga	ttattagtca	gcagtttcac	ttaaaggtct
52501	tttttatttt	tttggccagt	agactttctc	cttctacagc	tgcaactgta	ttaaatatac
52561	atccccaata	atttagctcc	tcttctttct	ctggtggaat	attttcagtt	atgtaatttc
52621	agctcctgct	gcttatttgg	ggtgattatt	attatatgtg	gtccctagcc	taggaatgaa
52681	ttctgctgta	gataccagtt	tttaaattag	ttagaattct	gcctggttcc	ccacaggaaa
52741	aatgtcataa	aagatgggcc	acaagacagt	ccaccaagcc	attttaaact	cccacatagc
52801	tgaactttca	tcattggcag	ctctgagttg	tgaggtctct	tgtgacactg	gccctggtta
52861	tttttaagag	gggcaagaaa	ggtaaatcaa	gagggtagtg	atagaagcag	gctagaaaaa
52921	gccaggcttt	ggcagctggg	ctgctctcac	gggattatga	ggggccatat	tctaagtagc
52981	aggaattgaa	agtggtgaat	ggattcaggt	cctgaccatg	catgaggctc	ctgtcaggag
53041	gtgccataag	agctgagcac	atcaatttga	agaagaggct	catagagagt	tgggtgtcct
53101	tcatgggacc	aggatggcgt	tgaggggtaa	aggtggacag	caattgcttc	ttatttgtac
53161	acagcttatt	tgggagttgg	agctcatctt	attaatgaag	gtaaaattat	gacttgaaaa
53221	ccaaccatat	ttcactacta	gagtatcatt	atttgatgct	ttcaaagtct	ccatgtgctt
53281	gcaccttatt	gatcttgtca	ccagttctcc	taaattccaa	tctggatgca	taagaaatat
53341	caaattgccg	aggtgggcgg	atcacaaggt	caggagattg	agaccatcct	ggctgatatg
53401	gtgaaacccc	atctttactg	aaaatacaaa	aaattagcca	agcgtggtgg	tgcacacatg
53461	tagtcccagc	tacttgggag	gctgaggcag	gggaattgct	tgaacccggg	aggcggagat
53521	tacagtaagc	caagatcgcg	ccactgcact	ccagcctggc	aatagagcaa	gactccgtct
53581	cgaaaaaaag	aaagaaatat	caaagtggtt	ttggtataaa	gagctagcct	tcccgttggc
53641	ctcaaggata	cgttagagat	aacagcaagc	tgtctaaata	tttgcagact	acaacattca
53701	aagataaggc	aagaggacca	atcttaaaga	ttttacaaaa	taattgcaac	aagtgcatgc
53761	atctgttgtt	tctcaaatca	tgttttaatg	ttttagctat	taggtgaaaa	tggctatgta
53821	caatgtgcta	tttttaaatt	gtcaagagta	gatttggaag	gttattatca	atatcctaca
53881	cttttccttt	cgtgactcaa	taataatttt	tgcactttca	tttagcctta	aaaaatagaa
53941	caataatgca	tccaagtata	aggtcaattg	caaagtgacc	cctgtagttt	ttgcttcaaa
54001	actattatat	tgtgctattt	ataatatcaa	attgccactg	tctagaggca	aaatgatcat
54061	ttcaaaatct	ttgtaacaat	ctagagaaat	atttacaaat	attagccaca	attctagtgt
54121	aatttttctg	atgtgtttct	attgctgaca	attgttttgt	aaaatcttga	tgattggtcc
54181	tcttgtcttt	gaatgtcgta	agtctggaac	tatttagact	gcttgctgtt	attgctgata
54241	tatccttgag	accgtcagaa	aacctagctc	tttttcccaa	caccaatttg	atatttctta
54301	tatatgcagg	ttggaattta	gaagagctgg	gtgacatgat	caataagtga	ttttgagaat
54361	tgctcagaac	ttcattttat	cttttttttt	tttctcaaac	aacctttaaa	atcagaaact
54421	ctggcatagc	actctccaac	tgtgccacag	aaggacataa	ggatgttggt	gctttttcct
54481	gtctattttt	gtcccctacc	aaatcacagc	cctggaaggg	agctttagaa	gtcacaaatc
54541	tgttctgttg	ccttcatgct	cagtatcaca	gaagagggat	aatcaaccct	cttctaaaag
54601	gctagccagt	ggaaaggatt	tcaaaatcag	ccaacaagta	tttttgctta	ctgtgtacat
54661	ggaacagtat	ggaaaaaaga	atatggaaaa	ctattagaca	ttattcatac	ccccaagaat
54721	cttgcacttc	atttggaaag	aatagatacc	tatatgtaca	caaaaaccac	catcaaaact
54781	tctgaatttg	gaacaggtct	tgaagaccta	actttctgac	tgttgtaaat	atgcactctt
54841	gacatcctgc	catttgatcc	tatcagttca	tcactgggaa	attttaattg	caaataaatt
54901	ctatccactt	ctaaattcta	aaggctttaa	tgcatgacag	gtctatagaa	gttaaatgac
54961	cgtagaaatt	gtcagcctgg	atagaaattt	tggctttacc	aatcattaat	agtgtggcct
55021	caggcaagtt	acttaatgtt	tttgcctttc	aatttcgtat	cataaagtgg	ggaaaaatac
55081	tagtatcttc	ctcatagggt	tgggagagtt	aggtgttgaa	ttttcagaat	agcccctgat
55141	agagggtaag	tccacatcac	attaaatggt	atttgtacaa	ctgtcataca	aatatttgac
55201	tcaactttta	atgttctgtt	ttccctgctc	cagctacccg	cttttttttt	taaaggtaaa
55261	acctcttcat	ctgtgtgatt	aatgatagaa	ctattccact	acggtcacag	aatatgattt
55321	ataactgact	aggtcctcct	tgttggtttt	taatgccacc	cttactacaa	atatggtatg
55381	aatagtaaaa	aaaagtgggc	caattattat	gttctaaata	gtatactact	aacactgcat
55441	cccaagcttg	caaaaatgtt	tcaggaaaat	ttttcaggtt	tcaggaggcc	acctgagtta
55501	gacaatggag	gccttaagtc	tattttactg	attgtgtttt	tcagaagctt	gagtttgttc
55561	tggactttag	cttccaattg	tgtgaaatgc	ttgaattgac	ccaagactat	gttaccgtca
55621	ttctgtcctg	tgtgttgttc	tttctcaaat	ccatggatat	tggtgaagtc	ctagtgtttc
55681	atattaattt	ctttggcaga	tattcagttt	aattctttgc	tgggatagtg	tgcatgggtg
55741	tgcatgtgtg	tgcatgcatg	cacatgtgta	cacgtgtgta	cagtatcatg	cttttgttcc
55801	actcatagtg	ggataaatat	attccttaat	aacctggtct	gatattcctc	ctggagtctt
55861	actgttccag	cctaccctgg	ccacactctt	gctttaggaa	ctctcacatt	tatccttcta
55921	agttgcttac	acaccaacct	cctcattttt	caaagcccag	ctgaaatatc	ttctcttctg
55981	tgaagacttc	ctagatcccc	tggccaggat	ttgtccccta	tcctctctct	gctccccagc
56041	attttgttaa	ttctccttct	cagttggcat	tttggttatt	gatgtagctt	ctgcttcctt
56101	tatgggactg	tagaacactc	tagaagaaga	gctttatctt	attcatcttt	gtatcctagg
56161	gcctagcaag	tggccatata	aaatttgttc	agctgaataa	agaaataatt	ttaaaaaaag
56221	aaataatgaa	aaggttcaca	tgggggtgta	ttttctttct	gatgttatca	tcctaattat
56281	tagaagacat	ggagggtctg	ggaggagaac	tgatttctaa	tgaacatcca	tttggtgcca
56341	tatcctactc	aatgtggttt	ataaattctc	tcatttgatc	tttgcaggga	ctttataaga
56401	ttagtattat	tatccccact	tatatatgag	taaaattaag	ttcagatagt	ttgaggcaca
56461	ggcagagtct	aatttataaa	ttccaggtct	tggaagtcaa	tgaaaactag	aatgaggact
56521	caaatttact	tgatgttacc	ctaaagccat	agacatattt	aatgacaccg	aagtacatga
56581	agtggtttga	cttctatgga	aaaaagctgt	ataaatatga	taatgccatt	ttctcattca
56641	aaaacccttc	aagagcattg	tttttgcaaa	ccaactaact	acattccaat	ttttcagcct
56701	ggcacttaag	agccttgata	ttcgtttctg	ttcttcaatc	ccattgcttc	taccttgatg
56761	ctctgtccag	ttggactgaa	ctctctggat	atctgcagat	ttctaccttt	ctacctttgc
56821	tcactctctt	tctcccacct	ggaatgcact	ttgtcaggga	tatacttgca	atattaatta
56881	gcttacttag	ccttatcata	atcaaataca	tggttctctt	aagcttttgg	aaaaattaaa
56941	ttctaagtgg	accaccattg	caaactctat	ggctctctgg	tggttcagga	atctcaggct
57001	agaaaaaatt	ctcttaaagg	aaaaaatatt	catattggta	aattttttta	aaaaaattta
57061	agtatagtac	ctttcattaa	ttccttggaa	acaatgctaa	aacttaagaa	cagagaaagt
57121	ttgttgttgt	tttgcttttt	ttttttaata	aaagaatcta	gcctaagaca	ccattctaaa
57181	caaatgtgtc	agactcatca	acctcctaat	caaaactttc	actcaactaa	ttctttcact
57241	tacctcctgc	ccactgcagt	tatctacagc	cctggctttg	gcaaaatatc	aggattgccc
57301	tattcatctg	cctattggat	ttgatccaga	attagtcaca	actttgttta	attctccagt
57361	cttcagtcaa	tctctggtcc	agcatgtata	ggacagtaat	tacacagtca	cacaatgcag
57421	cataatgtat	acttctcagc	acattcaact	ctgtgttttt	tagggtaggg	ggtgggagag
57481	agtatctcta	aagatgacta	aagcacagct	gttgggtgga	tcctccctac	aaatgtaaac
57541	caaaggattg	gggctgacct	cagagcgact	cccgagccgg	cactctctgg	gataatttcc
57601	tccatccctc	ccaatcctcc	cagaagggag	tctacttttg	ttcacatatt	tttatagaag
57661	gttaagtctt	tcatgggttt	tgtataaaag	ttgaaactgg	gttttgattc	cttgagatga
57721	gcagtggtaa	acatgtgtgg	cattcggaga	aacagcacct	tagaattaca	cctgttgttt
57781	gtgcggtgtg	gctctcttcc	tatggaaatg	tgtgaactct	cctaggagaa	agaagagaaa
57841	tatttaaaaa	atcaaatgcc	tcagggcaca	gagggttatt	gtgctcacaa	tctcttatct
57901	gcgatcttaa	aattcaaata	gaactgaaaa	attcaaatag	aactgacatc	tgcatttatt
57961	tatttattga	ccactcattt	ggagaccaaa	cctgaccaga	tctaaacttc	cttggcaaga
58021	tgacttgacc	ttacttattg	caagcctgtg	aatagtcttt	ccttatccca	gttagtgtga
58081	aaatccatgg	tgttgctaca	gaaatattca	tgtgtttgat	tagaggatgc	tgccttgaat
58141	ctcacagggg	ttatgtaaca	tagggcatgc	atatcctatt	tttttgtgac	attggaaaat
58201	ttctgaatgg	tgaaagtgcc	tggtcaaagg	gattttgaat	aactgattat	gacctataat
58261	gcaagagaaa	caaaaatcca	gcaaaatcaa	aatcagaatc	ttggttttca	acatccctct
58321	ctctttatac	cctatcatat	tcccccaatc	atatactcta	gtatgccaca	gcagcaattc
58381	ttgtacatta	tcaagatctc	aaatctaaag	atcttgattg	tccacacttt	cttccctcct
58441	tattctccac	ccatcattac	aatcgcttct	ttcatttgct	tacccctctt	attcttcatt
58501	gcacactcct	ggcgtatctc	catccctgtt	tccaccaatg	atccgtctat	tccgtgctgt
58561	cgccgaagca	gctgaacatt	gttaggggga	agaatcacat	aattgtgctg	actggtctca
58621	tttaaattca	taaccacaac	tgaactggac	actgttgtag	tgcagcccta	ctttatttcc
58681	caggttgttg	catgcttatg	tgacaatgtc	acaccttctt	atgacctttt	caaacgtctc
58741	tattgactgt	tctatcttgc	cccgcttttt	caactcatac	gtcattgaaa	aaatataagc
58801	agaaagtgaa	aatgaattaa	ctactctttc	tttcaccaaa	tcaaccaact	taattgcatc
58861	tgtacccata	tagtattcct	tctctcctat	tttgatagac	aaaatatccc	tggtcctagc
58921	taagccagcc	cctccacttt	tggcacctcc	tctgcctttc	tcaagaactt	cagtcctaca
58981	tttattcttt	ctctctctct	ctttccttcc	cacatcatca	gtttattcac	tgactccttt
59041	ttatctgcac	ccaataagca	gtagtggcca	ggtgcagtga	gtcatacctg	taatttcagc
59101	acttcagaag	gctgaggcag	gaggattccc	ggaggcctgg	agtttgcgac	cagcctgggc
59161	aacatagctc	atctttaaaa	acaaaataaa	acaacgttag	ctgggcatag	tggtgcacac
59221	ctgtagtctc	agctacacag	aaggctgagg	agaaaggatt	tcttgagccc	aggagttcaa
59281	ggctgccgtg	agctgtgatg	gttccactgc	actccagcct	gggtgacaga	gtgagaccct
59341	gtctctaaaa	caaataaaca	tgctgtagta	ttctctgtat	cccctccagc	tcttgtgctc
59401	ttctctggtt	tttatcacga	tacaacttag	gacataagtt	agcatcactc	cctccacttt
59461	ctctccttac	ccagttccat	caggtgatca	ctgccatctt	ttcactgatg	ttagtcttgt
59521	taaggtcccc	agagacctgc	aggtggtcat	tggcagtggt	cacttctctg	gcctcatcca
59581	agcctttcat	ttgtcccgca	tttgacctct	gtcttttaga	accattttct	tctcttggct
59641	tctgtgacaa	cacaatctcc	tgatgttttt	tcttcctgac	cttcttctca	catcgtttgc
59701	tgcctgtcca	acctctatta	gctggggtat	cccaaagctc	agtgctatac	ccctttctac
59761	tccttatttc	actaggtgat	cttattcttt	tccatggctt	tttaagtaag	gttccaaaag
59821	tacaccccca	gccttgggct	tgagctcggg	attcatatat	ctaattgcca	gtgtggattc
59881	atctatctaa	ttgccagtgt	aactctccac	ttgaaagact	agtaggcact	tcaaacttag
59941	cacgccaaac	acagaactct	tgacactcac	cacctaaact	gttccccctc	tagtaccgtc
60001	catcttagtg	agcacagcca	tcaagtcact	caaggcagaa	tctaactccc	tccttccctt
60061	aactgccaca	tgtaatccag	caacaggtct	cacctttgcc	acgtgtaaaa	tacaccctga
60121	gtttattcct	ttctctctgt	tttcctagtt	taagccacca	gtatctccca	cctgaactgt
60181	tatggtacct	tcctgcacgt	cttcttctgt	actctcttga	ttttttataa	ttgactctac
60241	ataacaacaa	atactgtatt	taatcttgca	catgtatttc	tatgtcccat	ttaacttagg
60301	ataattttga	actctttgtg	ttggctcaca	gggctctcat	gatccaaacc	ccatctcccc
60361	atctcccttt	cctgccctcc	ttggcatcct	ctctcccact	acctcccagc	catgctgcct
60421	tcttcctctt	ctttatacca	gccaagcgca	ttgccacttc	agggctttgg	aacttcctct
60481	tacctccccc	ctcgtagatc	tctacaagac	tcattcccct	ttggcactca	agtttcaaat
60541	taagtcaccc	ctgcagtcac	tctctgtcac	atccctctgt	gtgacagcaa	ttagagttct
60601	tgttggcact	tctccctcag	tgctcactca	gttagtcaac	aagttttatt	tttctccatt
60661	cctctctttt	cctactgcca	acaccctaat	agaagccacc	ttcctcactt	gtctggactg
60721	tagtagtagt	agcccctcag	ccatctcccc	acatttgtac	ttattccctt	ctaacctgac
60781	acttggtaac	acagctgcct	tacttagatg	actgctgtga	cttctcattg	ctcttaaggt
60841	gaatttttat	ttttattttt	attttctgag	acggagtctc	actctgtcgc	caggctggag
60901	tgcagtggcg	tgaccttggc	tcactgcagc	ctcctgctcc	tggggtcaag	tgattcttct
60961	gcttcagcct	cccgagtagc	tggctctaca	ggcgtgtgcc	accaagccca	gctaattttt
61021	gtatttttag	tagagacagg	tttcaccatg	ttagccagga	tggtctcgat	ttcttgacct
61081	cgtgatccac	ccgccttggc	ctcccaaagt	actgggatta	caggcatgag	ccactgcacc
61141	tggccgaggg	ttaatttttg	aatccttaac	aggagtctaa	ttctctgaat	gggctggctc
61201	tgacgtttct	ctttagctgc	accagaatat	gtaagcattc	gttcagttcc	ttacatgatt
61261	cacagcccat	ttcaacgaag	cacatgcttt	ttccttgact	ggtaatacca	ctttacctgc
61321	tcccttttgt	cttcttaact	catgcccatc	cttcaagtct	gagctaagga	atcattttct
61381	caagaaaacc	catcctgacc	acctcaaaac	atctggattt	tccccttctg	ccacataaca
61441	tcatagcatc	ctgtactgct	cattcacagt	acatatcagg	atggtattta	attcattcac
61501	ctttaatgcc	atcttcctcg	ctagaatgtt	tcatcagcta	taatgtcatg	gtaaatggcg
61561	ctggggccag	attgcccagg	ttctaaaccc	taattccttt	ttcttacata	gctgtatgac
61621	cttatttagg	ctttcttgat	gtaaaattaa	ggtaattatg	gtacccacca	tgtagatttg
61681	ttttgaggtt	taaatgagtt	aataaacata	aagcatctaa	tatagtgcct	ggcagataat
61741	aaacactcaa	taaatcatca	tgattgtcat	tactcttatg	agctctggga	ttgcatctgt
61801	ctcattcatc	atggcacatc	caacaagtat	ttgttgaata	cataaataat	atttttcatg
61861	agccaattaa	agttagaagt	aatattatta	aatgcctaga	tgtacgctag	gctaggggat
61921	atcaaaatta	ataaaacatc	gttttcacaa	tcaaggagtt	tttaactcag	tgaataagag
61981	tgagatacat	aaatgaggtc	tgctcaaatg	gtgtagttac	acatctttgt	gccctgggca
62041	ttttcctagg	agcctgatac	ggtttggcta	tgtccccacc	caaatctcat	cttgaattgt
62101	agctcccata	atttccacgt	gttgtgggag	ggacctggtg	ggatataatt	gaatcatcgg
62161	ggcagtttcc	tccatactgt	tctcatggta	gagaataagt	ctcatgagat	ctgatggttt
62221	tataagggga	aacctctttc	acttggttct	cattctgtct	tccctgtcat	catgtaagaa
62281	gtgagggttt	gtttgttttt	ttttgacaga	gtcttactgt	gtcacccagg	ctgaagtgca
62341	gtggcacaat	ctcggctcac	tgatccccag	ttcaagtgat	tctcatgcct	cagcctcccg
62401	agtagctggg	attataggtg	cgcaccatca	catctggcta	attttttttt	gtatttttag
62461	tagagccagg	gtttcaccat	gttgcccagg	ctggtctcga	actcctgagc	tcaggcaatc
62521	cgcctgcctc	aggctcccaa	agtgctggga	ttacaggcat	gagccaccgt	gcccagtgat
62581	gtgacttttt	cttccttgcc	ttctgccatg	attgtgaggc	ctcccaagcc	acatggaact
62641	gtgagtccat	taaacctctt	tttctttata	aattatccag	actttggtat	gtctctatga
62701	gcagcgagaa	aatggactaa	tacagagcct	accccatagc	ttgtgtacaa	tgtgtacaca
62761	ccaaaccgtg	acctgcctag	ctgtctccta	gaggaaagaa	ggggcactct	agagagaaca
62821	gaaaacagcc	tgaggaagtg	gcaatgaatt	ttgccttgaa	gggccggtaa	gatttcagca
62881	ggtacaattc	aggaaatgga	gaggtaggag	gcattccagg	aaggacacaa	gtaaaggcaa
62941	gaagccagga	aaatgaatgg	agagcatgaa	ccgtctgatg	gtggagcagt	ggttctcaaa
63001	gcatggtcat	gggcccagca	gcatcagcat	ctggcctgat	gattgttaga	gatgaaaatc
63061	tttggacccc	tgaccagatt	tactgaatca	taaaatccta	gtaatctgtg	tcttaacaat
63121	cctctggttg	attctgttgc	tcaccgaagt	ttgagaacca	ctgggctagg	gcactgtgtt
63181	ctcactgggg	acccacgaac	ctccagagag	ttgcagaggg	attcatgtgg	tgacaatgac
63241	agagcaagtc	aagagtcaac	ccccccacca	ccgcccctca	cccaataggc	aagggcaatc
63301	gtgtgtgggg	tcagagtcag	tgctgttgtg	acttggtgga	ataccactgg	tttcaacctt
63361	catagaattt	gggtggcttt	ttgttgttgt	tttgttattg	ttgttgttgt	ggtttggttt
63421	ggttttttga	gacagggttt	cactctgtca	ctcaggttgg	agtgcagtgg	catgatcatg
63481	gctcactgca	gccatgggcc	cctgggctca	agcaatcctc	ccacctcagc	tttctctata
63541	gctgggacta	ccggtgagag	ccaccatgcc	tggctaactt	ttttccttat	tctatagagg
63601	cgggatctca	ccatgttagc	caggctggtc	tcagactcct	ggagttttta	attgattttt
63661	tttcagctac	atattggggc	tgaaaaggtg	gaatttttaa	aaacacaatg	taaggaaaac
63721	tagtgttaga	atataagctg	ttgagaagca	aatgatagta	atatttctgc	aaatttagct
63781	caagataatt	ttcacaagtc	agatccacaa	gtcagatggc	aaaattctta	taaagcttat
63841	caagatgtct	caaatgctta	aaaaataaac	agaaaaaaga	gaaaaatata	gtaataatca
63901	tatctagttt	ggctttcgtc	taataaaaat	gtgttatttg	gaaagtgctt	gtaaatagcc
63961	taaaaatttc	tttcatatca	tctttagaac	ttaacaatta	taaaaatgag	ccaattgatt
64021	tttacattac	aaaatgcaga	cattctaaat	atcagctact	aaagtagtca	tatcttgatg
64081	atgtaacatg	taattaaatt	ttaatctaca	tttttaatat	acaatagtat	attaaatcac
64141	atacagtgtc	attttaaaat	ttataactca	accatccttt	tttcttacat	aattaaagta
64201	aatcaaacag	tatgtgtcat	ataataaatg	ggaaaaagct	atgattttta	acacatggaa
64261	cagatattat	agaaattttt	attaaatgaa	ttttgtaata	tggtcttaaa	taatgcactg
64321	atctaaagaa	atttaaaacc	cttttcaact	taaaattact	ttgcttcata	ccatggaaaa
64381	ttttaaagga	aattgttggt	gaattattat	gaaaagggtt	catgagtcac	agagagagga
64441	aaatgctgga	ctagtgcact	gggtacctgg	atctgggtaa	tgggggagtg	tatcagtctg
64501	ttttcacgct	gctgataaag	acatacctgt	gactgggtaa	tttataagga	aaaagaggtt
64561	taatggactc	acagttccac	atggctgggg	aggcctctca	atcgtggcag	aaggtgaaag
64621	gcatgtcttg	tatggtggca	gacaagagaa	gagagcttgt	gcaggggaac	tcccctttat
64681	aaaaccatca	gatctcttga	gacttattca	ctatcacgag	aacagcatgg	gaaagacctg
64741	cccccatgat	tcaattatct	tctaccaggt	ccctcccaca	gcatgtggga	attatggagc
64801	tacagttcaa	gatgagattt	gggtggggac	acagtgaaac	catatcagga	gatagaggtc
64861	aaggagagtt	actgcagaaa	ggtgaggaag	aaaccagtcc	aagagatctc	caggttgtgg
64921	gaagttttga	aaccctaggc	ataggtaggg	cttacttttg	gaagagggat	catttcctct
64981	gagctaaagg	ggaacgggta	caactttgaa	acgtttctta	aaatactgta	cgtgccagaa
65041	gtcagaatgc	tcatgaagtt	ctcaaagtcc	ctatctagaa	aattctggaa	caattgctct
65101	attcagtgaa	agttgcctgt	gttctggata	ccatcacctc	aagtctcctc	tggtacgttg
65161	ttccaccagt	tattgcacct	ctcctatatc	ttccatcttt	ccttttccat	tcacctttca
65221	ttagcaaatg	gatgaacaca	cattttaaac	ccgtattaaa	atgggtttac	tcaggcaact
65281	gtaacaaaat	atcataggct	gggtggctga	aataacatac	atttattttc	tctccattct
65341	gaggactaga	aggctaagat	taagggtttg	tgtctagcaa	ggcctcactt	gctgtcttgt
65401	agactgaagc	cttcttgctg	agtcctcaca	tggcctcaca	tgtgagggtc	cagatgagag
65461	agatagccaa	tgtcctttcc	tcttcttata	aggatatgtt	agggccccac	ccttaagacc
65521	tcatttaatc	ttcttttttt	ttttttgagt	cggagtctct	ctctcgccca	ggctggagtg
65581	cagtggcaca	atctcggctc	actgccactt	ccaccttcca	ggttcaagca	attctcctgc
65641	ctcaacctac	ttagtagctg	ggattgtggg	tgtgcatcac	catacctggc	taatttttgt
65701	gtttttagta	gagatggtgt	ttcatcatat	tggccaggct	ggtctggacc	tcctgacctt
65761	aggtgatctg	cttgccttgg	cctcccaaag	tgctgggata	acaggtgtga	gccactgggc
65821	ccggcatcat	ttaaccttaa	ttatctccct	aaaggccctg	tctccaaata	aagtcgcatc
65881	atgggttaga	gcatcaacat	gtgaatttga	ggggtacaca	attcaatcca	taacaaaact
65941	ctttaatctg	tgtatgtttc	cacttcttgg	ttttttccat	attcacccca	tggccacata
66001	ttaatgcatg	tgtcttagtc	agcttgtgtt	gatacaataa	attccatagg	cagggtagct
66061	taaacaacaa	atacttattt	ttcacagttc	tggaggctgg	aactgtgaga	tcagggtggc
66121	agcatggttg	gggttcttgt	tgaagaccct	cttcctggtt	tgcagactgc	catcttctca
66181	ttgtgtactt	tacccggtag	agggagaaga	gagagaaagc	aagctctttc	ttatctcttc
66241	ttataaggtc	actaatccca	tcatgcagcc	tgcaccctgt	gacctgatta	cctcccaaat
66301	gccccatctc	caagtaccat	catatagata	agtacatata	gatgagactg	acattattat
66361	tgagagtaaa	ttacatatta	aatacaccca	gcttttagcc	gttaaataat	gttgtgtttg
66421	tttgatcatt	tgtagatgaa	tcccattctg	ttttccacct	ttattacttt	tcttgtgtcg
66481	tcgcaagact	ggaagggcag	acagtccaaa	tcttcatatc	gaccccatgg	aaacttgctc
66541	aatgtatgaa	tagaaagggg	accatcagtc	agactgtcag	tctccaagct	tcctctctat
66601	cttgtggact	cagatgtcaa	ataatgtaac	tttcatatta	ggcaaatgca	aatatactag
66661	gttgtatgta	tctgtatgta	ttttgatgac	tgacacactt	tggtatcggt	cagcacacag
66721	aaaggaaaat	gtacaagatt	gtactcctgg	aaagaaacaa	cttttagggt	tttcaaagat
66781	tcccatacaa	aaaactttaa	agacaaaatg	caacacttaa	ttgaaaattc	agatttgtga
66841	aaaagaaaca	aagatataga	tatattcgta	ttatattttt	attatatatt	ctagatgata
66901	tattaatatt	tgatatggtt	tggatctgtg	tccctaccaa	atctcatgtt	gaattgtaat
66961	ccccaatttt	ggaggtgggg	cctggtgggg	ggtgattgga	tcatggtgct	ggttaattat
67021	gaatgggtca	gcaccatccc	ctcagtgctc	ttctcatgat	aatgagtgag	ttttcatgtg
67081	acctggttgt	ttaaatgtgt	gtagcacctc	ccttttctct	aggcttcctg	ctccagccac
67141	gtaagacatg	cctgcttccc	cttcaccatc	cgccatgatt	gtaagcttcc	tgaggcctcc
67201	ccaaaagcag	aagctgctgt	gcttcttgca	cagtctgcag	aaccatgagc	taattaaacc
67261	tcttttcttt	ataaattacc	ccatctcggg	tatttcttta	cagtgatgtg	agaatggact
67321	aatacaatat	tataaacagc	atctgtttga	atgttttcat	attctttttc	atatcaaata
67381	ttgagtatac	tattttaaaa	tattttcact	tttcacaaaa	gctaaattag	gctgattaaa
67441	tttaggcagg	gctttttgat	ttttacttat	atgtgtcttt	cttgtttgaa	ttattttaat
67501	aagaagatac	atggctttca	gaaagaaaga	gagaagagag	aagaaagaag	agaagaaaag
67561	aaactggcag	tgccggtgta	tctgcatatt	ttctattttg	tcttgacaac	gtatgcagat
67621	tatagaactt	cttaaaaggt	catttgataa	agtgaaacaa	atgacttcga	aaaaataatc
67681	ctaagggaaa	attgtttgga	acaattaaat	tgtaataaaa	ataatttaaa	ccactttgca
67741	attagtcttc	ttatgaacat	ctacaactcc	aaaatgattt	tgacaaaaat	gaatcttggc
67801	aaccaattaa	tgctcagtct	catctaattt	atttggtttt	cttgagagca	gagaaagctg
67861	aagaagattt	ctagaaatga	taacaattta	agacattcac	acacaattgt	attttttgaa
67921	aagcgtctta	tgtgaatttt	tattacaaat	aaaaatatta	caccttttgt	tgtcatctga
67981	atacactgca	ataactttga	agttgtctga	attgttatat	tcaaagcaaa	tctgcatggt
68041	gaagcttatt	attttcattt	attaaaaaag	aatataacaa	actattttca	gtaactgtta
68101	ctaactttat	ttagatatca	ccatctgcat	tttaggatta	tctgtacaat	aacaattgca
68161	ttgttacatt	aaatgcaaga	acccctcttc	tgcttatcat	ttttaagagt	aaagcaatag
68221	agatgaagtt	gcaacagtat	tggctattag	tgatatttgc	caagccaagt	ttctctctct
68281	ctctttctct	gtctctctgt	atgtagtgac	tgtaaagcta	accatcagat	ttcaagtgta
68341	gattatggag	tgtcttatta	tgtggaaata	ggcttctgtg	agctcataca	agtatgtgtg
68401	atggttaggt	tcactatgaa	ataccttaca	gataaaatct	cttttataat	ctttactata
68461	cattcattta	tgattcatca	aaaacaacac	aaagaattta	aaactaaatg	tatgcccttg
68521	ttatttgttt	catggaactc	atttgaccaa	gatgactaga	tcgattaaga	aaggatagac
68581	acacagaact	taattgctaa	gatcaaagta	taattttagc	aaatcaacaa	ttgccactta
68641	tttcttcaat	ggtacctatg	atcaagaggt	taataataga	ggtttatgga	taggactgtt
68701	tccctgtaga	aggcagaata	ccaaataccc	caaattgcac	tgcccgtgtc	tttcaagtgc
68761	ctatgattac	aaactaaaat	aaaaacatat	acaatgcaaa	caaacgaaaa	gccctatggc
68821	tacatttgga	caatacagaa	aacaatggaa	agatttgtat	ctcccttttt	cctcccctgt
68881	ctcctcacct	cagttttttt	ttctttttag	tagagagagg	aaagaaaaga	aaagtggcag
68941	aatccaaaaa	gagggaagga	gcaagaagag	gaaagagaaa	taggaggaat	tgggcaaggt
69001	gaaaatagac	aaaagggtta	ttttagttgg	catttcactt	gttcttccaa	taaaaggcat
69061	atcccatgtt	attttgctca	ttgcctttgt	ctgtctgctc	tctctgctca	cccctgtggg
69121	cccatcaggc	caccactcat	gtctgcctgc	tgggggcttg	tgtagaatag	agccccggca
69181	gagaagggct	tgacaatctt	ttacataaag	cctgagtaaa	gatccttcag	atgtgtgtga
69241	tcttcaggaa	gccattagtt	tctttgagcc	tctgttttct	ctattctaaa	ataagaaaac
69301	tgctgatgtt	acaaagtgct	ttggaggaac	aacaaaaaca	acagcacaca	tatccacacg
69361	tgcacacata	catacccgga	actcacctcc	tgctccttcc	tttaagccta	tgcatgcatg
69421	gctttatcta	atctataaaa	tgataataat	aactttgaaa	accaaaatta	tatatgtttt
69481	ttattatgca	agtgtaaaca	ggcagtctgt	agaaaaaata	catttaaaca	atataccact
69541	ctcaaaataa	acactaatgg	ttttggtata	ttcttagagt	ttttcttcaa	tgaatataca
69601	tacatatatt	tttatcccaa	aacacagttg	tatatgtcat	tctgcaactt	gctttttaaa
69661	tgtgacagtg	caattcagac	atctttttat	atcaatacat	atagattaat	cttgctattt
69721	ttaatagttg	catacttata	tgcctataat	ttattttaac	tcatcctctt	tgtggacatt
69781	tacataattt	tccttttttt	ggctaattca	agtaatactc	agtgaatgtc	tttgcatata
69841	gattgtgtta	atttttccgt	aggataagtt	cttaaagtag	aatgtttgtg	tgaaaggtat
69901	gctccatttg	aaattttgat	ggataacacc	atattgccct	cctaaaaaga	ttacatctta
69961	tttgcaatat	ttttcatttc	aattttccaa	gctagaaact	tctgggtcat	caccaagcct
70021	ctccctttca	ttttctagct	tccttccaaa	ttgtcaccat	atcctgtgat	catactgcag
70081	aaaggatctc	ctcatttcat	ccccgcatct	tcatccttcc	agccagtttc	tctttgctca
70141	tgtcttatag	aagaaacttc	caaaagttat	ccacaatcca	ttgtccttgt	catcctgggc
70201	acttgagaga	ggacatggtt	ttctaaggct	ccctggtatc	tacctggcca	tgccaatgga
70261	aagataaata	aaatggcaca	tgccccttgc	aggcttggcc	cctaggaacc	tgccattcac
70321	attcttcctg	ccatttcatc	ttctactggc	tgaatgttgc	cagttacaag	gccctgtggg
70381	aggtggaact	gcacatggca	gagcctgggt	ctctgagtga	acatgccaga	ggacagctac
70441	cccacagtcc	tgagtgactg	cccagagcaa	tgcctcttgt	gttgagctat	gacatggttg
70501	ggtctatttg	ttacaacagt	tagacgtcag	tagcagaagc	agagaggccc	catcattttt
70561	tactcacagt	atgagagcag	ccttcttgtt	ggcctctcta	actcctgctc	cttccccttt
70621	cagaagctct	gctgccagaa	taatcccact	ttgaaccaca	gtgacctgta	actccttcct
70681	ttaaagtctt	caggaactca	ttccctatag	attcagatcc	agactctttg	gcctggaatg
70741	gaagatcctt	tataacatgt	ccacagcctt	ccatggggta	ttgggggcag	agtcctcatc
70801	tatcttgtcc	tctgtgctag	acaatccaac	atacagtagt	gaaaccatcc	cccttccttc
70861	tcccctgatg	aaaactataa	agtgtataaa	ctgtagagtt	aatcagggga	gaaggaaggg
70921	ggagaaataa	aaataagcca	agcttgaagc	acactctgca	ttagtcatga	ggtcagcctg
70981	cttcctcata	gtggtttgct	gcctgttgcc	tcagaatcat	gtagaccctg	ttacaagata
71041	aaagttcccc	tttactgatc	tacagataac	ttgaacatta	caaagaattg	ttttcccttt
71101	gagatattct	ctcagttcct	gcataccaat	aaaactacta	gtgactcagc	tggtctgaag
71161	aaccccacag	gaggtgattc	accaaagaat	acagtttcca	catcctgatg	atttcatccc
71221	ccttaccctg	aaaaatgaac	aaccccaatt	ttccagcccc	tcaccctcca	tgtctccctt
71281	aaaaactcca	gcccagaatt	cctaggggag	atggttttga	aggggctcct	cccatctcct
71341	cactctgctg	ccttgtgatc	attgaactct	ttctctgctg	caagtcctgc	tgtctcattg
71401	tattggtctc	ttactgcaca	gtgggcatat	gaacttgctg	cttctctaac	agtagcattc
71461	aatacatact	tgcagaataa	atcaattcat	attgtttgct	ttagagacaa	atataatgca
71521	acatcaagga	ggcagtttta	taaaaacaat	ttgctttgta	gggttattaa	tttacgctta
71581	gcaattgcta	aaaatactga	tttcatggct	cacctcttga	gatagggtaa	aacagcatgt
71641	ttttgatatt	gctgatttag	gtccataaca	ttctaagcct	aaaagggcct	tagagctcat
71701	ctagtacaat	tttctcattt	tgcagataaa	aacactgcat	tccagacagc	tgaagagact
71761	ccaggctatg	aaaccagtgg	gatacagtcc	caagcaggcc	agcacccagt	tcataggtct
71821	gtctgccttc	tgtgacacca	ggctgtccct	aaggctaatg	gccctagaca	acttgatctc
71881	tgcagtctaa	tgtctgctta	tattcaactg	gctttgtggc	tccatttaag	gttttatttt
71941	ttggtgcctc	atttgtcaat	ttggtttccc	agtcttggtc	tgactgggaa	gaagcagagc
72001	cagtgtacca	tgcaggggac	gggatgttag	atctggcctc	ttgctctgca	ttcctctgtc
72061	acccatagaa	tttattgagc	ttcctcatgt	acaggtcctt	cttcattcat	cagggccaga
72121	ggctgctggt	gagcagggag	acattttttc	taacatggtg	ggaggaatgg	cagttttata
72181	actataatta	taccctccag	aaaataactg	ttacttaaaa	ggtgtatcgt	tctttgtaca
72241	tggatctgaa	ggctcagcga	tgggtacatt	taaaaatcaa	taaagtagtc	agccaaacat
72301	tcagctcatg	catcacaagc	tcacagggat	tcagatttaa	cagaaagatg	gggtaggcac
72361	tgcagtggtt	tgggccatgg	gcacctactg	tgtaaaggaa	cagaaacatt	gtaagacatt
72421	tcaaattgcc	ctgcacttgt	tcaggttagg	ttcatcttgt	cagatacctt	tcctattctc
72481	tctggtactt	ctccatcact	taggatgaat	ggtgaagagt	tttctggcaa	agtgcttgtt
72541	gcactttggt	gttaaccagc	tattgacagc	cacacacttt	gaagtgactt	ctcctacagg
72601	agtcactgat	ggacagcaga	gtgtagtgca	aatatcagga	ctgaggttgg	gaggtttaaa
72661	ttacaggttt	caaatgattt	tgggaggaaa	acttccattt	tcaaacaggg	tgaattatga
72721	gaaacaacct	gaaatgccac	ctttatgcct	cttcttataa	cctaaaaata	cagaatggtc
72781	ctgagaaagt	ttgctttggc	taagtagcat	atttgtctgt	aaactatgaa	attgctcatt
72841	cattcatcca	tacagtcatt	aagttgatac	atatttatta	agagtatcct	caacaccatt
72901	gaatatatac	tcaatgagtt	gttctatgtg	gtggaattaa	caataatgac	aaaccaagcc
72961	cctttactca	tggagtttac	atttcaatgg	aataagaata	ataatataac	aataagaaaa
73021	cataataagc	catgagagct	gcattggtta	tattttagtt	tgttgaaaaa	acccctcaaa
73081	ctaagtatct	taaagcaaga	gttgttcatg	atttcccact	attttgtggg	caagagggtg
73141	ggtcatttgc	tgccctcacc	tggactcaca	cttgtggctc	ctttgaaccg	gaaggtcagc
73201	tggtggctgg	gcttggctgg	gcttggctgg	gcgcactggg	tggccaggcc	cttctgacca
73261	catcatgttt	tgtctctggg	tggtcttagg	gttccatggg	aacaagtacc	aaagagcaag
73321	tgcttattga	gtttctgtgt	gtgtcatgtt	tgctaatgcc	ccacaggcca	gagaaagtca
73381	caaagctagg	ggcatggata	tgagaatgca	tgattcatta	ccgaccagta	gagaaacaat
73441	ctaacacatt	ggtaataaga	ggcaggaagc	aaactaaaga	atgagggaat	caacggagag
73501	tgatggggca	gttattttag	ataaggagat	caagatgact	ctctttgagg	agagaacatt
73561	gaaacagaga	cctgtgaagt	agggtagggg	gtcaagtgga	ggtaccaaga	gagtgttcca
73621	gccagagggt	tagcatgtgc	aaatgccctg	agtgggaaca	acagggagcc	agtgtggctg
73681	gagggcagta	agccaaggga	gaatgttatc	atagtggtgg	aaccttgtag	gctcttgcag
73741	accacggtaa	ggacttcaca	aggtgttcta	agatggaagg	aaacctgcac	atgctcgttg
73801	tagaaaaggg	aagaatttga	tttatgtttt	aaaaggatca	ctctggcttc	tgtgtagaga
73861	ataaacctta	taagagcaaa	agtggaagca	ggaaaagaag	ttaggagaaa	agagagagtg
73921	aggtggcttg	gaatgcaatt	ataacagcgc	agatggtgag	aaagagacaa	actcagcata
73981	tgttttgaaa	tcagggctca	cggtacttaa	aatggattga	atgtgggtta	tgagagaaag
74041	gcatgaagga	tgccttctag	gttattgtct	gaccaccttg	gtgagtggtg	tttctattac
74101	gagagagatc	gcattggctg	ggtcagggta	gaatgcaaca	tagaagatag	cggacatatt
74161	tagaaaatga	aatcaatgac	attgcctcac	aaaattctaa	agctgaaaat	ccagcaactg
74221	acataatccc	atcattttat	agacaaagaa	attgggatct	gggaaaatga	aggaatttct
74281	ttttttaaaa	aacactttct	gtaatcccag	cactttggga	ggctgaggtg	ggcagatcat
74341	gaggtcagga	gatcgagacc	atcctggcta	acacggtgaa	accgcgtctc	tactaaaatt
74401	acaaaaaatt	agccaggcac	agtggtgggc	gcctgtagtc	tcagccactc	gggaggctga
74461	ggcaggagaa	tggcatgaac	ctgggaggcg	gagcttgcag	tgagctgaga	tagcactatt
74521	gcactccagt	ctgggcaaca	gagtgggact	ccatctcaaa	aaaaaaaaaa	aaagacattt
74581	attaggccat	ttttgcattg	ctttaaagga	atactgggac	tggataattt	ataagaaaac
74641	aggcttaatt	gacttatggt	tctgcagact	gtacaggaag	catggtgcca	gcatctgctt
74701	ctggggaggc	ctcaagaaac	ttttattcat	ggcagaaggc	gaagtggtgg	caggcagttc
74761	acatggtgaa	agcaggggcg	gggccgggag	gggggaggta	ctgcacttta	ttagtttcat
74821	cctacaggtg	aaattagttt	gctgataaat	gtcaaatgct	ttaagatttc	ggagaaagtt
74881	atttagatac	tctgactcta	atttttttgt	ggagggagga	tcacattcga	taaacactca
74941	agagaataag	atagaggaat	gaggcaccgg	cagaagggtt	ttgtattagt	ctgttctcac
75001	cctgttttga	ataaatacct	gagactgggt	agtttataaa	gaaaagagtt	taatttactc
75061	acagttccac	atagctggag	agcctcaggg	aacttacaat	tacggtgaag	gcaccccttc
75121	acagggcggg	aatagagaga	aaatgagtgc	cagcaggaga	aatgccagat	gcttataaaa
75181	ccatcagatc	ttgtgagact	tgctcattat	catgaaaaca	gcatggggga	aactgccctc
75241	atgattcagt	tacctccacc	tggtcccacc	catgacattt	gggaattatg	ggagctacaa
75301	ttcaagacga	catttgggaa	ttatgggaac	tacaattcaa	gatgagattt	gggtgggaac
75361	acagtcaagc	cattttaggt	ttggtggaat	tgcttctttg	aaaatacagt	tgcagggacc
75421	tgtcttagtc	cttttgtgtt	gttataaagg	aatacctaag	gctgcataat	ttataaagaa
75481	tagaggttta	ttttgctaac	cgttctacaa	gctgtgtaag	aagcatggag	ccagcatgtg
75541	catctggtaa	gggtttcagg	ctgcttccac	tcatggcgga	aggggaaggg	gaaccagcat
75601	gtgaactggt	tgttaaaaag	agcagggcac	ctccctcccc	tctcttgttt	cctctgttgc
75661	ccatatgatc	tgcacatgct	ggcacccctt	agccttggcc	atgaatagat	ctaccccagg
75721	gtccaaacac	ctctcaccag	gccctacctc	caacactggg	gatcatattt	caacttgaga
75781	cttggctgag	tcatacaaac	cagatccaaa	tcatagaagg	accatagcta	gtttggatag
75841	attttaccat	caagaggtct	acccagacaa	atgaaagatc	tgtgagcatt	tgttgaatga
75901	atcttcaaca	aagtttaggc	attttgaata	tttaggtttc	cttgttgaag	cttgaaaata
75961	tgccttttgc	atttgacaaa	aattaagtta	cattctctga	agtctgttga	agtaaatttt
76021	tgtagtcctg	tcattcattt	cccactttat	tgagtacact	gctggtattt	ttggttgttg
76081	tttttaagct	ttctttattt	tccaatccaa	attgatgtgt	atcaggctgg	tatttttaat
76141	gttaatgggc	actcaaaatt	tagtgttcag	agaggtagag	aaggcaaaag	aaataggctg
76201	aaatttatct	taaatcaaag	agccaggcta	aaaggagtct	atgtcaaggg	ggcaggaggt
76261	atggttacta	cgaatttaaa	taggattccc	cttgtatgaa	attagcagtt	cttcattact
76321	cagcacgtcc	ttccccacct	atttccttca	tcatacttat	catccagaga	ttgctgaaga
76381	cagaaacata	ttatgatgac	ctttattagg	tgtttactat	attccaggtt	tgtagctaag
76441	tgctttataa	acattacctc	attattgttt	tgtccctaga	gtcaacgctt	atctgactct
76501	aatcttccta	gaagataggg	ccctggtttt	ttgatatatt	cactatacga	ccttcagcaa
76561	gtcattaagt	tccttatgcc	tcaggtttat	aatttatgaa	atgcaggatg	gatttttgtg
76621	tatactaccc	ttcaaatttt	atttctcttt	aaaagttatg	acttaaaaat	aattccatgt
76681	ttggctttat	ctaaggagat	gagggcatca	atggaaaagg	actttgaaaa	atgaaaaaat
76741	gaacaggtcc	ttctagaagt	tcgagttttt	gagaaaaaaa	ttgcgggaat	gagaagtctt
76801	cctttcccta	actcttttta	ctgctgattt	tatttattta	tttatttttg	agatggagtt
76861	tcactgtttt	gcccagccag	gaatgaagtg	gcacaatctc	ggcttactgg	aacctctgct
76921	cccccaggtt	caagagattc	tcttgcctca	gactcctgag	tagctgggat	tatagacacc
76981	tgccaccatg	cctggctaac	ttttgtattt	ctagtagaga	tggagttttg	ccatgttggc
77041	caggctggtc	tcaaactcct	gacctcaggt	gatccacccg	cctcagcctc	ccaaagtgct
77101	ggaattacag	gcatgagcca	ccatacctgg	cctcgtttta	ctgctttgaa	tggcaagatt
77161	cccttatgtg	tttcctagtt	caaattattt	tgttgtagtt	gtcaaaatta	ctttgtcctg
77221	tttttggagg	caagcatata	gtcttattta	ccaattagtt	tcagaaatgt	gagtagcata
77281	gcttctcaca	taggcagact	ttgtcaagga	tgatgtggga	ggaatattga	aggataagta
77341	gtccttagtc	tctgtgttag	cccattttct	gtagcttata	acagaatacc	tgaaagtcgg
77401	taatttacaa	gaaaaggaag	gtatttctta	cagttatgga	ggccaagagt	ccagggttga
77461	ggagctgcat	ctggtgagag	ccttcttcat	ggtagggtcc	acgtcagctc	aaggtatagc
77521	atggcaaggg	ggctaagcgt	gttgatgggc	tagctcaggt	ctctcttcct	cttcctataa
77581	agccaccagt	tcccctccca	tgataaccgt	gaatccacga	ctggattaat	ccattcaaga
77641	gggaagagcc	ctcatgatcc	aatcatctct	tgaaggcccc	acctctcaat	actgacacat
77701	tggggattaa	gtttcaacat	cagttttgga	ggagacaaac	atccaaaccc	tagtagcttc
77761	cagtacagaa	ttgccaatac	cttaggtact	tccaagtaga	gaattccccg	gaaaatctat
77821	tccttggttt	tggagattac	tctccaagtt	ctcgccaact	tgagtttccg	tggttctgtg
77881	agattctttt	ttcaagtaat	tcaagggttt	tcaggtagat	actgtcatag	attctgtttc
77941	aaatctgcca	attctactga	acacaaaaaa	aggttttttt	taatccagat	ttttttcttt
78001	tttttttttt	gagacagagt	cttgctctgt	tgctcaggct	ggagtgtagt	ggcacgatct
78061	cagctcactg	caaccactgt	ctcccgtgtt	caagcaattc	tgcctcagcc	tcccaagtag
78121	ctgggattac	aggcacacac	caccatgcct	ggctaatttt	tgtatcttaa	tggaaacgag
78181	gtttcaccat	gttggccggg	atggtcttga	tttcctgacc	tcatgatctg	cccgccttgg
78241	cctcccaaag	tgctgggatt	acaggctgat	ccagattttt	aaaaggttta	cttgagtctt
78301	agtttcatat	tatgaacaga	caatctctaa	gactgaagtt	taaaagttgc	actgaagtac
78361	agacttcaag	tccaagttta	caatttcagt	ttctcactta	cctcatttct	gatgtgcttg
78421	ttattttatc	tatattctgc	agagtgaaaa	agtgcagaat	gagagtcatt	aaggtctaaa
78481	ttggttgttg	ctaagggtct	aaattactgt	tgatgatgat	gtagcccttc	tggtggccta
78541	gctttgctgc	ttttggtgct	gagaggtagg	gcgaaggtca	tgggacttga	agtgggaggc
78601	aggaggaggt	gtgcggggtg	tgcagggtgt	gcatcctgca	gtttctgctt	ctgacattca
78661	atcttccacc	tttgaaactc	ttttttgggc	caggggtcac	cacttactat	aggtagaagg
78721	cagtcccaat	tcctccctaa	caggctgggc	gcaatgactc	acagcacttt	gggaggctga
78781	ggcgggcaga	tcacttgagg	tcaggagttc	aagaccagcc	tgtcctacat	ggtgaaaccc
78841	tatgtctact	aaaaatacaa	aaagtagctg	ggcgtggtgg	ttcacacctg	tagtcgcagc
78901	tgcttggaag	gctgagccag	gagaatcact	tgaacctgag	aggcaaacac	tgcagtgagc
78961	taagatggta	ccactgcact	ccagcctggg	taatagagca	agactccatc	tcaaaaaata
79021	aataaataaa	taaataaata	acaaaaagga	aaaagaaaca	tttaagtatc	cagtgtagac
79081	aagtatccag	ctttgtgtag	atagagaggc	cattctcaca	gatttctttg	ggtctgcatt
79141	atcttcccaa	accacaaccg	gtttttggcc	cagaaattca	aatttgctcc	ctgaagtctg
79201	tttttcttct	atgttgagct	tgtcactgaa	aagtcagttg	tcaatcttaa	cataatcccc
79261	tttctacaaa	ttccaactat	ttggttcttt	tgtctctcta	attattttat	tcaaaactat
79321	ctattcttgt	tttgggggag	aggagatttc	ccttcttatt	aaaaaccact	tagttatcag
79381	tgattataag	atcagcaatt	ccttgaggac	aaggattatg	ggttattcat	cattgtatgt
79441	tcactcatgc	ttaaacactg	gacaattttt	tttttttata	agcaagctac	agacaaccaa
79501	aatggggcaa	gggaattcaa	catgtaatcc	atgtttacca	aaacgagatt	tcctgagatt
79561	tccagcatag	caaatgtatg	tttctgtact	tttcttcctt	ttcttcaagt	aattgcaacc
79621	aactttctag	gctatgtacc	tgttaatgtc	agaaattgtt	ctctgtctct	ctctctgtct
79681	tccatgttgc	caagtgttgt	ggacagcaat	ataaattcct	taaatgaatg	aatgcgattt
79741	ttcaagccca	gttagtttat	ttttcagaag	aaccaagttc	tagtgaatta	aacttttatg
79801	atctagcaaa	tccgtcacac	aaaccagttg	ggaaaacacc	tataatttat	gcttcacaga
79861	ccttctgtct	acattctaaa	attttatttg	cagtgcctac	actgatttga	ataaattgaa
79921	aaccaaggtt	ttttttcttt	tcttttttca	aataaaacaa	acgagggttg	aacagttttg
79981	tatatttcga	attgtaataa	ttttatttct	ttcttcattc	cctgtttctc	ctatgaaatt
80041	aaaatgcaag	atttaaaatg	tgttgaattg	ttaagtatat	tttgtattta	ttttagacta
80101	aatcagagta	attaatagaa	attctaaatg	gaaatcacct	aatgatattg	ggttcaaatt
80161	ttgttgaagt	taatttaatt	tttattaata	atttatcaaa	tatagctggc	ttttgtgaat
80221	tatattaaaa	cgtatctttc	tgtgaagtgt	tgaggccaag	aatgaaacct	tagatggaag
80281	acccagattt	actggaagta	ggccagaaat	tgtaatcaaa	ggttttggac	tttctgctct
80341	gggtttaaat	tctagtccca	gcagttttta	gaagcaaggt	taatgaatct	ctgggcacct
80401	atgagaaggc	gtgttttgaa	ggccttcccc	aaagccagcc	ctctctaagt	ctctggcgtt
80461	cttttctttg	aatggatgta	cttaggagtc	cacagggagc	tatggacaca	gaggagagaa
80521	gaaaaataaa	attaaaaaaa	aaaaagctaa	tttcttggtc	atgattgttt	aaaaagaact
80581	tgcaaaagaa	aagaaacaga	agggtcaaaa	agacgaatac	aggttgagta	tcccttatcc
80641	aaaatcttgg	gaccagaagt	gtttcagtct	tggattttta	gggattttgg	aatatttgga
80701	tatatgtagc	accccaaatt	tgaaaatttg	aaataaaaaa	tgctccaata	agcatttcct
80761	ttaagtagca	tgtctatgct	caaaaagttt	tgaatttaga	agcattgtgg	atttcagagt
80821	tttggatttg	ggatgctcaa	cctggaaaag	gtaactcctg	ctcacttcca	cccctcatgg
80881	agaaatttct	taaaacagaa	caagctctca	tgctccattt	ccatcacagt	acacattgtg
80941	aggacatgaa	acataatgtt	ttcagtgttt	ggttatatga	gaatcaaata	gcttcctggg
81001	gaagaaaata	ctgaatttta	cacaacccat	atgccactaa	tgggatcaga	tggcaatata
81061	gtaacacgca	gcccagttct	tcatgcttca	tccaaaaacc	atgccacgga	tttggggttt
81121	ggacactgaa	tttgtcactg	tctgcatgat	cttagataag	ttactttatc	tcagtagtgt
81181	aggtggcatc	atcggcccac	catcacgact	gatggcccct	gagctgacaa	taaaaaacaa
81241	gtgtacatct	ttaataccag	aaagtagtca	gtaaatatgt	ggacgtgtgt	tgtgagtggg
81301	tcttatctgt	accatgagag	gtgttagtct	gagatctcta	aaaagggagt	gcctagaaac
81361	caagcatgga	aatgtgtcaa	accgtcacca	agagtgaaag	atgatcagga	accagagaaa
81421	tagccccaga	atagagctta	cccacaccag	gagcagtaac	ccctggctac	cagtaaatcc
81481	cactgcttgg	tctttgctcc	tctctgacat	attttattgc	agcccaagct	catggacagg
81541	ctctcatccc	atcaccctca	acatcacctg	tgtttcaggg	ttgttctgag	aatcaaacag
81601	gatttaccct	aagctcttca	gggatgtcag	tcaaggttag	catgatgcag	ggcctataag
81661	tttactttaa	gagtatttct	caagagtcat	cttctatcaa	aggcagtctt	ttccaagtca
81721	gcttgaggcc	acacagtatt	ttgaaaacat	cgtggacttt	ggagtaaaaa	caaatgtctg
81781	caatttgttg	tgttctgtta	ctacggattg	gcctgatttg	agatacttat	ttaacttctt
81841	tgagcctctg	tttcctcatc	tttcatgaaa	ctaagatact	gtctctaaat	ggtgtcacaa
81901	agtagtaata	taataattaa	cagctgaata	tgaataatgc	cattatgcct	ttctggtaag
81961	actcactgta	ggtaaacact	ttgacctatg	ttattttatt	tgatctttat	agaaacatgg
82021	gaggatagtg	atgtgcctac	ttttttgaat	ggcctgctag	gtaatttgtg	ccaccctgaa
82081	agccagccta	atggacaggt	agtgcaaaag	aagcaagagg	gtgttcagtt	tcctgcatga
82141	acagagtcag	caactgacat	ctgagagcct	ttggggctat	ttcatcctgg	ggtttcaagc
82201	tcagcttcaa	agggactgga	gaatgaggca	cagatgagaa	gatggggatc	ctatctcctc
82261	cccaacttca	attgcagcag	ctacatttct	atgtgttatt	gattgaattt	ccatgtaaga
82321	ttccaatgga	agaaagttgt	agtcaagcac	tttcatttcg	caaatggcaa	aactgaagcc
82381	gatattgtgg	ttgtgactta	tcccaaagta	atatacacat	aaacctctat	ggatgaggaa
82441	aaagacagag	ggaaactaaa	aattcaaaag	aacaaatttg	actcacagat	ttgctgactc
82501	atagttatga	tagttatttc	ctctacccac	gctttcttga	ctgattgaat	aagttgcagt
82561	ttttgtcctc	aattaactca	tcggaacatg	acattatttt	aaactattga	accaccttct
82621	tcattaaata	gtattttttg	agagtttact	atatatgtca	ctgtccaggt	acaatgaaaa
82681	ataccataaa	gataaagcat	tctacactcc	atatggatag	aattcagatt	gcgtagatga
82741	ctcagtctta	tgagaaggtg	gtatataatg	acaatgacaa	ataagtgtga	ccatcttttt
82801	tttttttttt	ttttgaaagg	atctcactct	gttacctagg	ctggagtgca	gtggtgcgat
82861	ctccactcac	tgcagccttg	acctcctggg	ctcaagtgat	cctcctacct	caatctcctg
82921	agtaactgct	accacagtta	tgcaccacca	cgcccggctt	tttttttttt	taattgttag
82981	cagagacagg	atcttgctgt	gttgctcagg	ctggtctcca	actcctgtcc	tcaaggaatc
83041	ctccatgcct	tatgctagga	ttacaggcat	aagccaccgt	gcccagccag	tgtgaccatc
83101	ttgaaaggag	aaattacaca	aaactcaggg	tgctctaggg	aagtttattc	agaagttgag
83161	gttttagctg	gtccctgaag	aatgaataat	attaaaatag	gagacaagaa	gacacgagat
83221	tccaaatgta	gaatatcttc	atagacttgg	aaatctcaag	gctcctactg	agaagatgaa
83281	aacaaaattg	gtatatctag	agctaaaggt	ttatgaaagg	aagttggtaa	ggcctggaat
83341	cactaagcat	tgaacagtgg	atcatcaggt	gacagctgag	gccgttcctc	atattacaga
83401	agcaggaaat	gtgttccagg	agccagctcc	atcgtctaac	cctacagtat	ggggctgtcc
83461	ttccccgtcc	tatgccatct	ctctgccccc	actggatcaa	attcacagat	aacaagattt
83521	aacacatcat	ttcttaaact	cctactttgt	caccaccacc	tctactcaat	tcccaataaa
83581	ttggaatata	cataacacag	gaagcaggaa	acaatagaaa	ggctttgagc	aaggcacagt
83641	gtctttgaaa	gatggattta	gtgagtatat	ttgaactgga	aggatctata	ggtaaatgta
83701	ggcaaggggt	ctgtgaagga	atccatttat	ttattttatt	tattattatt	tttttgagat
83761	ggagtctcac	tctgtcaccc	aggctggagt	gcagtgtcac	gatctaggct	tactgcaacc
83821	tccacctccc	aggttcaagt	gattctctgg	ccgcagcctc	ccgagtagct	gggattacag
83881	gtgcccacca	ccacacccag	ctaatttttg	tattttttag	tagagacagg	gtttcaacat
83941	gttggccagg	ctggtcttgg	actcctgacc	tcaggtgatc	cgcctggaaa	gaatccattt
84001	atatgaacat	ttcttgtgtt	cctatgtgat	gtgtgctcta	tgtattattt	ccaatttaat
84061	tttaagacaa	cccaattagg	ttgataataa	tatctcaatt	ttataaacac	gcaaactaag
84121	gcacgatgag	atttaagtaa	ctttcccagt	ctcaattcac	tagcaagtaa	gagctggggt
84181	ataaaactaa	acctttataa	tgttaaagta	catccccttc	tttattcttt	atttttaggt
84241	caaaagcaga	tggttgagtt	aattattttc	ctcagttcaa	gacacattat	catctttgat
84301	gtgtgcaggg	cccctttgga	agttttattt	atttattttt	atccttttaa	aaaaattcct
84361	atgccctgtt	ttcattcctc	tcttttcaca	gccaaaaaat	tcagtgtgtt	tgatgtgtat
84421	ttgttatttt	atatgtgttc	ttgaaaaatg	agtattatta	ttttgtgtgc	atatattgtt
84481	aatttatgta	agtgatatta	attatgtatc	ttcctccttt	actttttttt	cacgaaggac
84541	tattttttta	aagactcata	catatttcta	tggatgcttc	taatccattg	cttctaactc
84601	caacttctgc	cctttcaatt	acatacaatt	aattccctaa	agcaaggggc	agactcggga
84661	gacatcactc	ataaatatta	attaatcaat	taacatatta	aaagcaattc	agtcaacaaa
84721	acatttgtta	agcacttact	accagacact	gtgtttaatg	ttgagaatac	tgaaatgagt
84781	aaagtttaaa	acctaaactt	aggggactgt	cagtccagta	ggagacacta	tcatggaaat
84841	aaataattac	agtttagtga	tttatatgca	gtcatgggta	cgacctcaag	aaagagggac
84901	agcacagaca	gggtgtgatt	gttttcattg	ggagcactgg	gcaaaatgag	tgaaacgtgg
84961	aataaaaaga	atgacctttt	ctgagtttca	aagaatgtgt	aggaggaacg	tcctgagtgg
85021	atgggtgggg	aaagggtgtt	ctgggaaaca	gcactttcga	caagaattgt	tgcattccct
85081	gtcttctctg	gggcccctta	aagtccatgt	ccactcacag	gctcttaaaa	cagcagccat
85141	gtttactctc	ctacttcctg	agctgatagt	cttgaggagg	gcctctggtc	cctgctacac
85201	agccatccct	gatcagtgct	ccagcagcca	tgcgcatgtg	tagtcttggt	taaacaggtg
85261	agttggtcct	gtctactgtt	tccctggaga	atttgaacca	aaagatccag	gcatgttgcc
85321	atagcagtgg	tgaccggaag	tggagctggg	agatcttgat	gcctggtggt	catctgcatg
85381	ctaatgaata	aacaaagcgt	gggcttccaa	gcaaagcgag	agaagaaagg	ctcccctggg
85441	taaggagaaa	cgccatcttg	ctttctgaca	cttttctcag	ctctactctt	gcgagctgga
85501	ttttgcttcc	cgtcttgagg	tccatgaagt	ttatctgagt	cttgataatc	aatatccctt
85561	attgtcaact	attttgtgtt	tcaattgctt	attacccagt	gatgttgaat	aaagcatgta
85621	ttccaaggca	taaagacccg	agagactgtg	atctgttgac	agagctataa	tccccttgtt
85681	attgacaggt	atgaaatagg	tgggtggggt	tggaggaaaa	gctgaaggaa	gaaccaaaaa
85741	gacttagtga	ctgattagaa	atggcacaca	gagataaagc	aaatctgaag	ttgcaagctt
85801	ggaagcccca	gaagaaaggt	ggtaatattg	atataaagct	agggaaatga	atgaatagag
85861	aagaattcaa	tttttaaata	catgagaagt	ctttgggaaa	catgtgaaca	tcaaatggta
85921	aattagagaa	agatgagctt	agatgcctgc	actaacctta	gagaggaaaa	ggaagaggac
85981	tcagtgaagg	ggagttagga	atgagaccaa	gagtggtcaa	agatgggggt	tacagaaaaa
86041	tataaaaaag	tagctgttga	taatagtaaa	aaacacagtc	gagtccacga	aaatgaggat
86101	tatagaaaaa	aatcaatgct	caacagccct	ataaatcctt	tcatttcaga	agttttcagt
86161	gcctttaata	tgcttcccca	tatctgtcta	tgatcacatg	gatattatct	tgggtagtaa
86221	attcctggtc	tatgggaatt	tgctctgtta	aaatttgctt	tatttaatac	tcaatacaat
86281	gccgtgtgta	cttaccaaat	atgtttttat	taataagacg	aagaaggttc	tcgtgctaaa
86341	gttctcttga	ctgctaaaat	tagaaagtgt	caattttgac	ctctgtggct	gtggggagga
86401	acatctgaag	cctcgatgtt	cagatgtgac	atataatgaa	gcctcttctc	tatgcatcct
86461	tcaagtggtc	ccagctaatt	tggatgggga	attttgaggg	aatttaaatt	tggggatttc
86521	ccatgtgaag	catcactttg	caatcatgtg	cttagctaaa	aattctcctt	ttcgaggatc
86581	gctcatgcta	gtgacgcgtt	gttagtttgg	agagagaata	aaggacaagt	gttgccttcc
86641	ttcctgtgcc	gcagacttaa	ccaactaatt	aaatccactt	tgctttctgg	gcttatggtg
86701	actttgtgta	attcagactg	gaatcttgtc	acatccagaa	gatctgtcgt	tgtccaggtt
86761	accatggcag	ctaatttttt	ttttcttttt	gtagaattat	ccccagccct	tggcttcagt
86821	taaccacata	agcaggtgta	ttattagctt	aatgaaggga	ccctttctgc	aggcttcttc
86881	ccatgctgtc	aggtagctgt	ccaactcgca	tgttgttgct	gtgtttagta	tcttattctc
86941	agcatccatc	tggagctctt	ttacaaagcc	ggtaggttgc	gtgccagaga	acatcttgct
87001	gcctcggaag	aaaattcatc	tccttttttt	ttcttaaatg	tgacccatga	catcacattg
87061	tcctccccag	cccatcctga	gctctgcact	gaggggtggc	tttgttgcca	tcctaggcat
87121	gcatagctat	tgtctgtgca	atgcttcatt	ttgcaagtct	gtagctataa	tgcaacatac
87181	tctgggatca	gtttcaaagt	ctaacgatta	acacatgttt	attcattcca	aatggagcca
87241	cggctgcagt	ccctgctgca	cacatgttat	tggggatttt	ttaaattgtt	gttattattt
87301	ttcctctcta	ggttgattct	tcacatggat	cagaagcaac	cagcaatgaa	ctcctgaaat
87361	ctttgtttac	tgcctttgag	gaacctttgt	acccttgccg	tttctccatg	aggtgtgtcc
87421	ccagatcact	ttctggatgg	caggcaatgg	ccgctagaag	gtcagttttg	tgccctgctt
87481	taagtgtcac	tctgtatgca	tgctcccaca	gtgtaatgac	agccaagtag	tgacaaatgt
87541	agccttacag	actcaaggca	atagtgcaca	ccagaaaaac	acagatgggg	aaaaaagcaa
87601	tttttgattg	aatctaaaat	atggcaggta	aacatttaat	gacacaaagg	cagacattca
87661	caaagaggtt	aagaaattag	gacatatttt	tttgtaagcg	aaaaaaagtc	aaacataggg
87721	ttgtcattat	cagctactgc	agctggtgct	cacacatcct	tgggaggcgt	cccagagtgg
87781	catggtcagg	ctcctgggca	gagatggtaa	actactgacc	cattaccctc	agaatgacag
87841	tgatgtcagc	tctactcagt	gacccaggga	gacagcagca	ttaaccagta	tgcaaaaaat
87901	atagatgaaa	tttggagcaa	attgatttac	tgagggatta	cttttggtta	aatgattttc
87961	cctcctttct	gagccctatc	catcccaagc	cgaattctct	gagctaaatt	gaagtttctg
88021	caaatgcatc	ctagcagtgg	aggttaaaga	gtcactgtga	aatttatttc	atccctgaat
88081	ttacagcttt	gttaggcaaa	actatataaa	aaccataaaa	agaaagaggc	taaaaataaa
88141	aatggaaaaa	ccaataacaa	acaagcaatt	ccagccaact	ctttttcctc	tgctcaagat
88201	gaaatgaaga	aagtgagcat	ggtatgtaac	aactaatggt	aattttccca	gccttaatag
88261	tctacaaatg	atcacagata	agggatatgt	acatatccta	atttattccc	ctgacctaaa
88321	cattgctctc	ctaacagtca	cctcttctga	acctgctgct	ctctctgata	tgacaatcac
88381	ttgtaaatct	tgaaagacag	ttaagccgtg	attgtaattt	tttatacata	gtatctaaca
88441	cattaggaat	gcagagtaaa	tgccaagcta	taatcattta	aatgtccttc	tttatttatt
88501	tcatttctca	tgttctgtgt	ttgaatgaag	actcatggaa	acccttgttt	tcgcatttaa
88561	tcacgcagtg	ccaggtggcc	ccagccccag	gctcaagaca	accattagca	ggtttttctg
88621	ctagggtgga	ttcatcctct	atatacattt	ctgattgtct	ataaatagca	tcacttgtga
88681	ggattgttga	aataatttgt	tgctataatt	atagtgacat	ttctagcatg	ttataatcat
88741	ataaaactgc	caaaatagga	ggatgctatt	ttggactttt	tttttccagt	ttagtttgtg
88801	tttcatggaa	tggaagaaaa	gatgaggaat	gcctctggtt	tagagaagga	gccacattat
88861	aacagaagag	aacaatgaca	cacaaaaatc	aggagtactt	ccttcagaag	aaaggcagct
88921	ggagcctttg	aaattgacat	agttttagtc	aaaaagaaga	aaagaaagat	ctccaaaata
88981	tacaattcca	tacatgcaag	agaagtgaag	acatgtgatg	atatttttcc	agctgaaggc
89041	cttagccaaa	ccaaagtcat	tttaattttt	cataggcttt	tacatttttg	atgacaacat
89101	cttggttgag	gaatcacaaa	tgtctgaaaa	agaagtcgca	aggatggttg	cactgtgaaa
89161	atctttgaaa	aagtcagtat	gttttgaatt	gacattgtat	ctccactgtt	ttcaaatgtt
89221	cagccaatgc	caattaaaca	aaataaagat	gtatgttgta	ttagttcatt	tttatgctgc
89281	tgataaagac	atacccaaga	ctgggtaatt	tataaggaaa	aagaggttta	atggactcac
89341	agttccatgt	ggctagaaag	gcctcacaat	catggcagaa	ggcaaaatgc	aatttacgtg
89401	gcagcaggca	agagagagaa	atgagagcca	agtgaaaggg	gtttcccttt	atgaaactat
89461	cggatctcat	gagacttatt	caccattgtg	aaaacagtat	gggggaaacc	acccccatga
89521	ttcaattatc	tcccactggg	tccctcccac	aacacgtggg	aattatggga	gctacaattc
89581	aagatgagat	ttgggtgagg	acatagccaa	accatatcat	atgtattgat	aaaatgctgt
89641	tagctagtga	acaatcacat	actttgagga	ctgtaccaca	gttgtggatg	ttttcaaact
89701	aaaatggcat	actgtatcta	cataagttgt	gttgatggac	aaaattagaa	aatgtcaatg
89761	tttattttag	atgcaatttc	tcttttttct	tagtgcccag	tgctgggacc	tactcatttg
89821	acctgcctga	tgacactaaa	caacaaagtg	ggaattggct	ttcttggcat	taatcaaggt
89881	tataatttta	tatgtatttg	taggatcttt	cccccacatc	tgtacactcc	aagaaggtgc
89941	agatcctgtc	tggttggaac	tcagtcatat	tttcagcaag	gtgacaagtc	ataggtcatt
90001	ttgaggtgaa	cgaatgaatg	gtggaacagg	aagacttcca	aataatcctt	gctctgaaat
90061	ttacaagttt	tataagctca	ggccagcatt	tcccttcttg	gagcctcaga	ttcattcttt
90121	acaaaatggc	tgatttggct	tggaggctct	ccaaggtcca	tcttaagttc	cagaagcctt
90181	caattccata	aatgaatata	cagtagatgc	cctagggctc	taccaccgcc	tctcttctga
90241	aaactgtttg	cacaacccgc	atctccgtct	cactgcagca	caacattccc	tggagatagt
90301	catctaggcc	agagttagac	cccagatcct	agctggacgg	agcacctgct	tttttccagg
90361	tatttggtgc	taggcctgag	gacctgccat	ttggaatctg	cttacagctg	ctctgtgacc
90421	tgcggatttg	gggaccctgg	gagtgactgc	ctcctgccca	gtgtggaggg	ctgggcagag
90481	acagccagaa	ggcagagaga	gaggaataaa	gccgtctcca	gaccagagcg	gacagagcaa
90541	gtggagactt	ctggcagttg	ccatcccttg	ctgaaagctg	agggttccat	aagggagctt
90601	gtatactcat	agtgaatttc	ctttttgccc	tttttttgga	tgaaaagtag	ctctaattag
90661	ctttgttttg	tatccagaaa	cccaactaat	aacatacatc	cattcttttc	agtagttaaa
90721	cctagtttaa	ctggtgattc	tggtgaagtc	tcctagactt	ttcaaagcct	cattcataga
90781	agcctaaacc	cagtatttgt	tgtgaacagc	attatcagtg	cctgtgaggc	agtctctctc
90841	tggggtgaac	cgcaatttag	gcagtctttt	gtgtttctac	acagcaggaa	ccttataaaa
90901	ctggagaggc	aagagtcttt	gacctaggat	gagtccatag	cccatttctt	tgccccattt
90961	ttaaacaggt	tggtcttgcc	tcctgttgtt	gatctttgag	tcctcccctg	cacacctgcc
91021	tggaatgctc	agctcttcct	gctcacctcc	gcagacttcc	agagcctgga	cagaagtcac
91081	ttccctgaca	gatatcagca	caaatctctg	tctacctttg	gtctcctcca	aactgccctg
91141	tcttcttgtc	acgcacatcc	taacttcata	tttcctttcc	tgatctcatt	gagaaatgag
91201	aaatcgggtt	atgggttatc	taattccatt	agcctcatta	ttccttaggc	atctcagtcc
91261	cggagagcta	atgccatgtc	atagaaggag	tcggaagact	cggagtccac	cagtaactct
91321	gtgatcttga	acaaaacccc	ttctctcttg	atttgtaaaa	tgagacctaa	attgcataat
91381	ttgtgggata	cttccatctt	cactctaggg	tctatttcag	ataaaatccc	ctccccactc
91441	tcagttctca	tctcaatttc	tttctttttt	catttttatt	ttattttatt	tttagacgga
91501	gtttcactct	tgttgcccag	gctggagcgc	agtggtgcga	tctcagctca	ctgcaacctc
91561	cgcctccctg	gtttaagtga	ttctcctgcc	tcagcctcct	gagtagctgg	gattacaagt
91621	gcccgccacc	acacccagct	aatttttgta	tttttagtag	agacggggtt	tcgccatgtt
91681	ggccagggtt	ctctcgaact	cctgacctca	ggtgatcctc	ccgtctcggc	ctcccaaagt
91741	gctgggatta	caggcgtaat	ccactgtgcc	cagcctcatc	ttaatttcta	ggttcctacc
91801	actccctttc	ttggcatgaa	ggggtggggg	tcttgtttgc	aggtggaact	tttccactgt
91861	gggtctctcg	gttttattgt	agatgtttta	aagtctcaac	taaggttcct	gacaggcaga
91921	gggaagatgg	gatgggatgg	gggaacagtg	ctcttcaacc	tggaggggcc	tggagggctc
91981	aggccactca	atacgtgcgt	tagtatattt	tcccacattc	ttgttcctgt	ctctttcctt
92041	gttaggcaac	accaccctgg	tctttttttt	tttttttttt	tcttgcctta	tctttgttaa
92101	gctttccaca	ttcctactcc	atcagcatgc	ttttggctga	caaacttgaa	gctttcccct
92161	tttgcttgct	ttgcagctat	catctaatct	tgcaagagat	gagaattctt	gacatgtttt
92221	tgttaacttc	ttttgttgcc	actatgagct	ccacctaatt	ctgagactga	catcccccaa
92281	gcagcaggca	gtgaggcaag	gctctggggt	ggctggcctg	gccttgccac	tctgaggcca
92341	gtattaaaac	actgagtggt	tggtttcatt	ccctacatta	ccaacttttt	cttttttctt
92401	ttatttcttt	ttctttttct	ttcttttctt	tttttttttt	tttgagacgg	agtcttgctc
92461	tgtcacccag	gctggagtgc	agtggcgtga	tctcggctca	ctgcaagctc	cacctcccga
92521	attcacacca	ttctcctgcc	tcagcctccc	gagtagctgg	gactacacgt	gcccaccacc
92581	aagcctggct	aatgttttgt	atttttagta	gagacaaggt	ttcaccgtgt	tagccaggat
92641	ggtctcgatc	tcctgacctc	gtgatccgcc	cacctcagcc	tcacaaagtg	ctgggattac
92701	aggcgtgagc	caccgcacct	ggctttcttt	tatttatttt	tctaatctaa	attttaaatt
92761	atttaaaaca	ggatctctct	ctgtcaccca	gggtggagtg	cagtggcatg	atcatagctc
92821	actacagtct	ccatctctta	ggcttaagtg	atcctctcgc	ctcagcctcc	cgagtagctg
92881	ggactacagg	catgtgctac	cgcactcagc	tgattttatt	tagttttgta	gagatgggtc
92941	tcactacatt	gcccaggctg	gtctcgagct	cctggcctca	agcaagtctc	ctgcctggcc
93001	ctcccaaagt	gctggaaatc	cgggaatgaa	ccatcatgct	cagctttgct	gtcttaatga
93061	gagccaattt	agccactctg	gctgaaaccc	ttctcttcat	atgacagccc	agccatcaaa
93121	catcagttgg	atccaatagt	tgagtatgtg	ggcttcttca	gtttcctagg	catggctggg
93181	tgaccagaga	aagagaagtg	cccactcaac	tgtccaccaa	tttggaattc	tatcattcat
93241	aactagcatt	tatattacgg	cagattttga	gcgataaagg	tgatcacaca	attgcaaaac
93301	atgctttctg	tatatttatg	accagggttt	tttcatgcct	ctctcactga	cttccacccc
93361	tggtccttgt	caagcttcta	agagtttctc	agtgcctttt	cccccagagc	ttagatcata
93421	tccaaggaaa	gattgaaaat	aaagtaattc	actaagtgga	aaagaggaga	tttttttatg
93481	actatcagtt	tgcaaaaaca	aaattaaaga	taatacaggt	tcatgcaatg	tcacggataa
93541	tgacaacaat	ctagataaca	gccaagaaaa	ggcaacttta	ttgctttctt	gcaaacaagc
93601	caagaacaat	agttcatcaa	gtttccacta	tattcataat	ggagcatttt	atgatcttct
93661	aaggagaagt	ttgatgaaat	gcaagactgt	gctttagata	aaaatgtcaa	ttttcattaa
93721	aatctttaag	tttatttgtc	acactttctt	tctaaattcc	aaactaattt	ctttggggct
93781	catgtctcta	ttaatttgct	tgtttctttt	gtaacataaa	agctgtgaca	tttagattta
93841	aaatgaccat	tgtttctgca	ctggatgttc	ttggcctgtt	atttccttca	taatttttac
93901	tacggctttt	ggggattcat	tcacttagtc	ttggcagtta	ctgaatcttc	ttgtcctttg
93961	cagctataga	gatgcctcaa	gttggcaaga	aagaaaagga	agtctttgtg	ccgttgaata
94021	ccaaatctgg	tctctattac	agtgccgaag	gagtgctgtt	tggaatgaca	ttggaaacag
94081	ccaaagaaca	tctccaagac	cttctgacgt	tgatggagag	aacctctgac	tgaatccttg
94141	gtggccaggc	aggcagggca	gctcattctg	aatgagtaga	aatctcattt	ataatgttca
94201	acctaggtaa	catgttttag	aagacaactt	aagtcagagg	gaaagcctat	tatggccaaa
94261	gcctgaatat	ttgtccagtc	ggctgttaat	ccagtcagct	ttgatggaag	aattggtaat
94321	aggaagattg	ttctttttgg	cttgttgggc	tggagtcaga	gagaggggga	cacccacatg
94381	gccagaaagc	tgagatgtca	tagctagata	gtcctcgcaa	atgccacttt	accaaacagc
94441	cttccattat	gattgtctgc	aaatgaaagt	taacactgct	acacctggca	aggaaattct
94501	ttgcagagcc	atgggtgtag	ttaccacact	gcactgcagc	agtttgggag	aagatgctga
94561	attagggtga	acctccagta	gcctcttctg	ggcttcttca	tggaaaggaa	gtgagagagc
94621	ttcctgaagc	aggagatggg	acaggtgcca	ggcaacagaa	gaaaatcagg	ccctgcacaa
94681	tggatcacgc	ctgtaatcct	atggcttttg	gaggctgagg	caggaggatt	gcttgagctc
94741	aggagtttgg	gaccccatct	atacaaaaaa	aaattggcca	ggtgtggggt	gacatgcatc
94801	tgtagtccca	gctactcagg	aggctgaggc	aggaggatga	cttgagccca	ggagttcgag
94861	attgcatcac	tgcactccag	cctgggtgac	agagccagac	tctgtctcaa	aataaataaa
94921	gaaaagtcaa	aaaaagaaaa	tcagcgattt	ggccctacca	ggccaggatg	caggaaccct
94981	ggctgggaac	ccaagaggca	gtgggaaaag	caatgttagg	gttccaagcc	cttgtggagt
95041	gagtgctctg	ctccactgct	ggtctgagcc	aaccccctgt	gttcatggca	cctctacttt
95101	gcgttctgag	agcttgggct	tggcagtgac	ctggatgagg	cagaaaaagg	gagacaggat
95161	tgtgggacag	gcacagaatc	tggagacagg	gctactattt	gctttctttc	gagggaggag
95221	cacaaaagcc	aaatatgaag	tccttccttc	caatcttcca	ttgtctgaat	tgagctgact
95281	cactgcagag	taaactcatg	gatagccttg	gtttttccag	catgaacagc	tgggggcaac
95341	ttcacaaggg	tgtgagattg	gggagctaga	atggtgcctc	cagtgtgtgt	gaagacactg
95401	gagagtcata	tttacaccgt	cacgagctct	cctcccagaa	aatcatcacg	tttattatct
95461	tgccaattaa	acctgcataa	atgcatgggc	aaggtaggag	aaaaatggaa	aaaatgcaca
95521	gttcatttcc	ttctctggtg	ctgtttactc	tacatgagat	attattaaaa	gagaaaggtg
95581	gtaaacaggc	agaaaactgc	cctgtaacac	ccacaggtca	accaaaaaag	tctggtgtga
95641	ttttaatctc	agcaattttt	gaaatttagt	gatgaagaga	aatgctgaac	cccctttctg
95701	gcgtgttaaa	taatgataat	gtatgcttta	aaaactcatt	acaaccatta	acatgaataa
95761	ctagtgattt	caaatttgag	ttaaatagtt	aggctgctac	atttatgttc	tttgggtgtt
95821	tgaatataat	tatttgagga	ttaaattgag	acacatcgat	cggtcccaga	aataaataac
95881	aggcttgctt	gcaaagccaa	aattggaatg	gagaaatgag	aattcttaga	gaaaatatct
95941	gttgtatgaa	tgaatgaata	aaaaggagat	attccacaca	ttaattacag	gaagatttca
96001	ggaaaggatt	tggttgaagt	ttttaagacg	atgatgaccg	taatagatga	ttttaagaaa
96061	cacttttgat	tttgtttctt	gtttttatga	tttctaagat	tggagaagga	atttattaaa
96121	aggacaaaaa	tgtactttta	ttatttagta	atcttcttga	tttggacaaa	aactgatgag
96181	aggctacctt	tcttgaaata	aaaggagtat	ctaggatgca	tttaaacatt	atctcaagta
96241	tcagttactt	agatattaaa	tcaaaacaaa	cccactgcag	tatccttcct	tcctaataga
96301	caaatcctta	gtaatttata	ttgtatccag	agaaagtgga	atttatcatc	aaagctaagc
96361	aaatcagtaa	ctctttgttt	cgttacagag	gtaaccttgg	atttggtggt	gttgaatgta
96421	tttaaacctc	aagatcagtt	ggctacatat	attttaggaa	aaaagaaaat	cctttcaatt
96481	aaaatttttt	acagtgtaaa	tgtgttttga	gtgatttaag	ttggaccccg	aaggttgatt
96541	ttaatgtact	ttttttatta	aggatttcat	tgatgtacaa	gttgaggata	cttttggctg
96601	aaagtgctat	tgagatgtta	ggaaaatatc	aagcaaggtg	agcaaaatag	ccaacttgca
96661	agcagtattc	agaaggtctc	accaaaataa	aatcatcaaa	gaggagcttt	gaaatgcaat
96721	gtggaacgga	atgcaggagg	cattttcaaa	ggctttctgc	ctttggactc	acagaccacc
96781	aaaagattag	caagattctg	atgtacagga	atgttaggaa	gtttctgggc	tcactcatcc
96841	ctcagagact	taaaaagatg	acaaaaattc	aaaccgtcaa	gccattttgt	aatataaaaa
96901	agaatccaat	ccatccatgc	ttgtaatttc	cataaattag	ccttgtagac	cagcatggtg
96961	ttttgtaaca	tcgtggagca	atgcattata	caaattagac	aagggctctg	gccaagaaca
97021	gttttaagga	aaatgacaga	tcctttgctg	tttctcgcac	actgagctca	gatcttctct
97081	gtctgactag	aatcacaaag	aggaaactga	atattttatc	caaaatatta	ttataaaaca
97141	gtgctacaaa	ggcccttccc	aagagacaga	tcttgcagca	aatatcagca	aggcaggagg
97201	aaggagaggg	tcctcatagc	ctcctgtctc	tgtcagtaac	aggcagtcgg	taggacttgg
97261	actccgaagg	catgggctgg	atttgcaaat	tgcattttca	aaggagcagg	gagatacaat
97321	taggaagatc	aatgtatgaa	aacagcacct	gaggctgctg	gagtggaaat	gcaaaattgt
97381	gctgaggatt	caagaaccgt	tctgacatgg	ctgttagaga	cgctgaaatg	tgatttaaaa
97441	aaaaaaaaat	ttgccatttc	tccaccagaa	cccccagctc	ttgccaagaa	atcacctctc
97501	tgagcttcta	tttcctccct	ttgactctcc	cctcttcctc	atcctcattc	tcacctccat
97561	gcctttgaat	actgtttgcc	tcacctagac	catctattcc	ccatgccttc	ggatgaattc
97621	taacaatcaa	caactattca	ctatatgctc	tgtgcaagac	attctgcttg	acatttagag
97681	aattcagaga	tctccaagac	ccaggcactt	cccttaagat	gttgaaaatc	cccttaaaag
97741	gataaaaaac	caaatgtata	agagataact	agaaacagac	acataaaatc	tccaaatgtg
97801	cgggagtgag	acagaaattc	agaagagaga	cattatcacc	tgggaagtca	aggagacttc
97861	atggaggtga	attgaactaa	gccctgaagg	caaagcagga	ttcaggtagg	tagaatcaga
97921	tagggctggg	gatgtgggct	ggcatttccc	gcaggagctc	gaagcagcat	aggtaggcag
97981	gaaggatgaa	gaaaagagat	tgggagagat	ggcgttagag	aggttcaggt	gtctggagca
98041	gtgagtaact	tacttgcagg	gctaatggac	tagcattttt	acattttgct	aggttacgta
98101	gtaagtgaaa	gggagttgct	agaatgaagg	ggtgttttag	gaataattta	caggacccag
98161	tgaaacatga	aaaacagggt	cccttcttca	aaaaggaggg	aaaaaatttc	cattaagttc
98221	ctaaaataga	aagtcaatat	cttttttctt	ctgcagtctc	tctccaccta	tcactttgtt
98281	gttggttttg	ttttgtttcc	ctatttaatg	tcaatttcct	tgggcacaag	acgcttgcag
98341	gaaaagtgca	gtctcccatg	ggtacctggg	gaccccaccc	tgccctagtc	cagtgtgctt
98401	tgtcctggcc	gaccatgggg	aagttgagcc	aggcatcttc	cctccccaag	gtgtgctgct
98461	gcaacccatg	gcagatgagt	gacctcaagg	gtgttgcact	tggatgtgct	gggtacttgg
98521	attgggtcta	gtaaaaggct	tacccctgcc	aagttgcctg	tccagggctc	tgtgatacag
98581	gcagcccagg	tcagggatgg	cagaagccct	gagactccgt	agggcacgtg	tccttcccga
98641	agcctgtgcc	tacccccgct	gagagaggag	ggcagtggct	attgctgcag	aagcaaggaa
98701	gaggaggtca	gtggaatgca	gaaaaccaag	cacaggggtc	cagcaaccca	tgagaggaga
98761	cagaaagctg	cagggaggca	gggttgcatg	tgagctgagg	ctccaagtcc	cagtgcatgc
98821	tccagtgtcc	caccagactt	cagtcacaaa	gcacaaggtc	aaggtaaaat	tgttcaggat
98881	tccaaggcag	tgatcacaaa	gcattaaacc	ccaaatgcct	gagtttgagg	tcacctgtga
98941	ctgtagtggc	tgcatgctgt	caagctggcc	tttggggcag	cagagagacc	tgggaaatgt
99001	caatgccctg	gcacgggcgt	ctgggtgtga	cgcaggggta	gcaatggagt	gggaaagaac
99061	ggaaccataa	aagcaaggaa	gggaagtctg	tggactggaa	agaaaaataa	agcaaagaca
99121	attattgcat	ttgggacttg	ggtgatacag	aaaaagacga	cactctaata	taaaaacgaa
99181	acgaagcaga	agtcgtttta	tttctgttac	aattttagct	ttgtaggtag	ggttggagga
99241	ggggcaaaga	tacgatgttt	cattttggac	ataacaagtc	tgcgttggga	gaagttactt
99301	ggacgaagtg	tctgataggc	aggtgaatac	accccaggga	acttgaggga	aaggtaggga
99361	ccaagacaaa	gatgctgcag	aaatttgccc	agaaaggagc	ttccaagaag	tagatgaggt
99421	ctttaagaga	gaaggaacaa	ggaggggtga	gcagagatca	gagaataggc	tcacagggta
99481	cctgccttta	aaggacagag	agaaaggggc	ttccaggggg	aagaggagga	tctgcagaga
99541	ggaaactctt	gcataaggct	aagagaagag	tgaatcttaa	aaaggatgtc	aatggagtca
99601	aatagcccag	aaaatcctgg	agaatgagga	caagaaaata	attcttattt	ataattccca
99661	aaggtattgt	ttcagtggca	taattaagtg	gctgactgtg	tgcatgggag	ggctgtatgc
99721	aaatcatgac	tctgtggctg	agttgtctag	gatggacaga	gcagaagggc	tttagaagca
99781	gggtccagat	tcaaatctca	atttggactc	ttgctagttg	catggtgttg	ggcaagctac
99841	ctaatcttgc	taaatgccat	ttttctgagc	tgtgaaatga	gtaggtaagt	aggatattca
99901	tatgggagct	atcatacctg	gttaattttt	tgtagagatg	gagtcttgct	atgttgccca
99961	ggctggtctt	gaatgcctga	gctcaagtga	tcttcccacc	tcagcctccc	aaagtgctag
100021	gattacaggt	atgagccacc	atgatcagtc	aaatacacat	tctttttttt	tttttttttt
100081	tttttgacag	agtcttgctc	tgttgccagg	ctggagtgca	gtgacatgat	ctcagctcac
100141	tgcaatctct	gcctctgggg	ttcaagtgat	tctcctgcct	cagcctccca	agtagctggg
100201	attactggtg	cgcaccacca	cactgagcta	atgtttgtat	ttttagtaga	gacggggttt
100261	taccatgttg	gccaggatgg	tctctatctc	ctgaccttgg	aaacacacat	tctttaaact
100321	aggcacatga	ctgctctgct	aagatgataa	ttcccagcct	cccttgatga	tagatgtggg
100381	catgtgacaa	agttctggct	tatgggagat	gaaataaagg	gatatgggca	agtttctgtt
100441	cttcctttat	gtttcccctt	cctgatggcc	agaacccaca	tggatggctg	gaactgattc
100501	agcaatcttg	gaccaggcaa	cagaagtggt	gggttgaggc	taatgtagaa	aaaagacaga
100561	aattgcctga	atctgctacc	ttgtggggct	tccaaccttg	cctgtatttg	gactattaaa
100621	tgagagaaat	actttttttt	ttaaatttaa	gtcactggca	ttttggctcc	ctctatataa
100681	ctgcacttgt	atcctaagta	ataatatact	tgtgcacatt	taaaaatcgg	ggtataatac
100741	ttacttcata	caatcgtaag	aactgagccc	tctctgatcc	ataaaaaaca	ccagacccac
100801	tacctacctc	attgtaatta	cttaatcaat	gttttctgaa	tacatgaaca	ttatgaccag
100861	aggacacggc	tgagagaatt	gccaaggtat	gtatgagaaa	tagtagtggg	agttacattg
100921	ttggctacat	tgtagataga	tgttaaagga	tttgaatttt	attctgcagg	tagtagctcc
100981	tggtggttag	taacatacag	aaattgagga	catgcccatg	cattttgata	caaatggaaa
101041	attcaatatt	tcttgagctc	ctatttgatg	ccaagcattg	ggaaaacaaa	ggtaaataaa
101101	ccagtctttg	tccttaagct	tcttgctcaa	agcaatcatt	atattgttta	aaagcttgga
101161	ctctagatcc	agaatgtctg	cttttgaatc	ttggctctac	tactagctag	ttggtgacct
101221	tagcaaatca	attcacttct	ctttgtttca	ttctctgtaa	aacagcaatg	acaataacat
101281	caactttata	ggattgttat	aaggaatata	tgagctaata	cctgcaaaat	gcataaaaca
101341	atgcctaata	ttaagtgctc	agtttctgct	agctattata	tcagataact	attgctacat
101401	aagaaaccac	ccttaactcg	gtagcttaaa	acaacaaaca	tttatttagt	tcacaattct
101461	tcaggctggc	aatttagcct	gggcttagct	gtgtggttcg	tctggtcttg	gttgtgctcc
101521	agtatatgtc	tgcagttagc	tacaggttgg	ctaggtggct	ctgctttcag	ggttagtgga
101581	tttctacggt	catagctatg	gggtgacagt	gacaactaag	tcatttgtct	ctcatactct
101641	agcatacttg	tcaactttgt	tctcatagag	gaggcaggat	tccaagagaa	agtagaagtg
101701	tgaaaggtct	caagtcctaa	gcacagaact	ggcatagcat	tactccctcc	atatgatatt
101761	ggtaaaagca	attagcaaat	tcaaccaaat	ccaagggaag	agcaacaaag	tcacattgca
101821	aaggatgtgg	gcacaggttc	aacaggtgta	attaatttgt	ctcagtctgt	cctctggtct
101881	taattattca	catcccttct	acatgcaaaa	tatgctcgca	ccctcccaag	accctcaaac
101941	tctcattcaa	tcatggcatc	aaactccata	tcaattctgc	acatggttcc	ttggatgtga
102001	tgcgtcttga	tctggggcct	gtgaaatata	gagtcaagtt	agtacttgtt	cagaaagacc
102061	caacatataa	tgatgacaca	aggcacagga	caagtgtggt	aaatactccc	attaaaaatg
102121	aggaggaata	ggagacacta	gcagtaactg	gtccatagca	attctgaaat	cccactgggt
102181	aaatgtcacc	agatccccca	actgtgggag	tgggaaaaag	ggagtgttgg	ttccctaatt
102241	aaaccttgct	tctgatcctt	ggaagtggtt	ctttggtcta	tttttctaca	aatttcttct
102301	tccaccttgt	ggtttcctag	ttgtgccccc	tgagatggtt	ttcttttctc	atcactcttc
102361	ttggctacat	ttaaataaat	agcccatgtt	agcagataaa	tgtctgtctt	aacttactta
102421	tgcctattga	aagtgggaag	cccaaagccc	tttgtacatt	ttgaacaatt	tcagcccctt
102481	ttagtccaag	ctggccacat	gtttttcctg	tacaatttcc	taaacaatgt	agtgggtttc
102541	ttactaatct	gattatttta	cccacttcaa	tggggcagaa	gccaacacca	caattgtttt
102601	cttgacctgg	ctctctagat	ttacctactg	ctacattgag	actaggtttt	tgtgaaatta
102661	tgacattaat	attctagaag	tctttggtcc	agaccagatg	gtctacttta	attatttttg
102721	aggcctcaac	aagagatcat	acagccacac	ccttgatttg	atctatgtct	tagtctatat
102781	tttactttga	gaatcttctg	ctggctgaag	agactacaaa	tgagtaactg	ttatattttc
102841	taatccagca	agtcattcta	tttacaaatt	ggccagttct	ttctttatct	catctttcct
102901	tggtgttcgt	tgtcatatgc	agcaagaagc	aaccagctaa	cactttcaac	attttgcctg
102961	gaatctcctt	agccaaatgc	aaacatttgt	taggcatatt	tttatcttcc	tatcttatat
103021	ctctatctct	gtattgaaat	atctatatat	cttgctgcag	gtgagaatta	tctttgaaat
103081	aacagcatta	ttgagaaata	tttcatatac	tataaaattc	actgtttaaa	ttgtacaatt
103141	cagtggttgt	ccaaccatca	ccactatcta	acttcataaa	atttttgttt	ttccaaaaac
103201	gaattctgta	cccattggta	gtcactccac	actactccct	tccttgggcc	tctgacaaat
103261	atttatctaa	tttctgtttc	tattgattag	cctattctga	ccatttcata	taaatgaaga
103321	tttacaatct	atgggctttt	gtgactagct	tctgtcagtt	agcataatgt	gcagggccaa
103381	cagttttaca	agtccttttg	ccgttacata	aagcaggttg	ccattttttt	agctttaaaa
103441	acaatttcct	caccatttct	ccagcctttg	ctgataatgt	gcttatggcc	tctccatcct
103501	ccaccctctg	actggttcta	aaatcaatgc	tgcacatttt	caatcttggt	tatgtcagca
103561	ttccatttct	ggtaccaatt	tcaggatcag	gatcattctt	tattaccaaa	atcatgttgt
103621	ttattaaaaa	acaaacttca	gtggcatgca	ataataatca	tttagttttt	tttcatgagc
103681	ctacaggtca	gttgggtggt	ccttctgggt	gtgattggct	caactatgta	tctgatgtta
103741	acttcacatc	agattgaatt	attctgacct	ctcttgggtg	ttgactcact	gtgggcttat
103801	ctgtcatggc	ctcacaagga	gagctgggct	ctccttcatg	tggtctcttg	gcctccatag
103861	gccagcctgg	ctccttcacg	tagtggctgc	gcagagcccc	aagagaggaa	gtggaagcac
103921	atgaggcctc	tcaaggccta	gagtcagaac	caacatgctc	gcttctgccc	tattctattt
103981	gccaaagcaa	atcacaaggc	cagctgagta	tacacaagca	catgcatgca	cacacataca
104041	cgcacacaca	cacagaaaga	gagatttatt	ataagaaatt	gactcacatg	accatggagg
104101	ctaagaagtc	ccgtcacctg	ctgtctgcca	gctggagact	cagaagagct	ggtggtacaa
104161	ttccagttct	actctgaagg	cctgagaacc	agaaaagctg	agggtgtaaa	ttccagtcta
104221	agtgcaggag	accaacgaca	cagctcaaaa	acagtctgac	agaaagagag	tgaatcctcc
104281	cttaccccac	ttttttctca	gtcccttaaa	tcaatagcct	acaagtgttg	ttgtaaagtt
104341	aaagttttta	aactttttat	tttgaaataa	ttgtagttgt	aagaaataat	acagagagat
104401	cctgtttacc	ttttatttgg	ttctgcctca	tgttaacatc	tcatataact	atactaaaat
104461	attacaagta	agaaattgat	attgatacac	tcagcatatg	tatatataaa	taaatatata
104521	ctatataaat	agatatattt	atagaaagag	aaattgatat	tgctacactc	tgcatatgta
104581	tttatatatt	atatattata	tatttatata	tgcagagtgt	agcaatatca	atttcttact
104641	tttgatatat	atataatcag	agtgtatcaa	tatcaatttc	ttacttgtga	tatatgtata
104701	tataatatat	atatacacac	agaaagaaag	agagagagag	aggagagaga	gagagagaga
104761	cagggtctcg	ctctgttgcc	aaggctagag	tgcagtagtg	caatgtcagc	ttactgcagc
104821	ctcaacctcc	caggctcaag	ctatcctcct	gcctcagtct	cccaggtagg	gaccacagac
104881	atgcacaacc	atgcctgcta	acttttgtat	ttcttgttag	aaacggggtt	tcaccacatt
104941	gcccaggatg	gtctcaaact	gctgagttca	agtgatcctc	ccgtcctggc	ctcccaaagt
105001	actgggatta	tagattcatg	cccatcccac	tctgccaatc	ttattctgat	ttctccactt
105061	ttacatgcac	atatttatgc	atatgtgtat	ttaattctgt	gccatatttt	cttatgtgta
105121	gacttgtgtg	accatcacta	cagtcaagat	atagaacagg	tccatcacaa	ggacacatta
105181	ggctaccttt	gatagccaca	gccatttccc	ttcccttccc	actccctagt	ccctggcaac
105241	taactactac	atgttcttca	tttctataat	ttgttttttt	caaaaatgtc	ttataaataa
105301	aatcatgcag	cttataacct	tttgatattg	gctctccttt	ttttgaataa	ctcccttgaa
105361	atccaaccaa	gttgtgtgta	tctgtggttt	aaagctcctt	tttcttgctg	agtggtaatt
105421	cacagtatag	atgtaccaca	gtctatttca	ccattcaccc	actcagaaac	atctgggcca
105481	ttcccaggtt	ttagctgtta	ggaataaagc	agcaacaaac	atttatacac	aggttatttt
105541	gtggacagaa	ctcttgattt	ctctggaata	aatatccagg	agcataattg	ctggatcttg
105601	ggatgagcat	gtgtttagtt	ttataacaaa	ccagcctaca	cttttccaga	ttggctgtgc
105661	cattttatat	tcccattggc	aatgtaggag	gtatccagtt	tctcagcatc	cttgtcagca
105721	tttgatattt	ttaatttctg	ccattcaaat	aggtgtgtag	tgatatctaa	tgtggcttta
105781	atttgcattt	ctttaatgac	taaagatgtg	gggtgtactt	tttatgtact	tatttgccat
105841	ttatatatcc	tcttgagtga	agtgcctgtg	tatgtctttt	gcccattttc	taatttggtt
105901	gttatattct	agcagttttt	cattcctagt	ctcttgttta	ttcatcttcc	tataaagtaa
105961	cctaaatctt	accttgtatt	taagagattt	ttctatggaa	gagaatgaaa	agtcttatta
106021	aatctccaat	acatttttag	atagcgtact	catactctgc	gtgataaatc	attttatcag
106081	gaaagcaaat	agaattggtc	ctgcccaata	gtttttttct	caaagtcact	gattatttcc
106141	tagtctcttg	tgatacctta	caggggctaa	agaggaatga	tttgcttaag	ctgatcttac
106201	acgtcctgtg	cttatgcaaa	aaagcttagt	gttaagcccc	actaaagttt	gttgtttgta
106261	catctctaaa	agaaacagtt	ggccaagcgc	ttaggtagca	tggcaggtag	ggaccacaat
106321	agtatagttg	tacagttgtc	tgtgtttgat	ttgtaaccag	caaaaccttc	tcactcagaa
106381	aaaaaaagag	cagctttcag	ctcctggtac	tgctgatctc	ctctggtgtt	ttctgttaaa
106441	catgtcctag	atttgctaat	tgtgtttttt	atttaatgag	ttcaagaggc	aggcatttat
106501	tgtatccctc	gctaataaat	cataactgct	gattcagcat	ttctacaaaa	tgttaaacaa
106561	caatacaatc	aagccttagt	aattagttaa	tttagggaaa	caggaagaat	tactggactc
106621	ttgctagaaa	ttatacgata	attttttttc	tgcttttcca	tgctaactta	tagtaacctc
106681	cctttccccc	tttgcactgg	tttccttcca	agcacaggat	ataacctata	acctaaagaa
106741	ttgtataagg	ctttgctact	ttttttgggg	ggtcacgctc	tgttgcccag	gcaggagtgc
106801	agtggtgtga	tcttggctca	ctgcaacttc	tgcctccctg	gttcaagcaa	tcatcccacc
106861	tcagcctccc	aagtagctga	gattaccagc	atgcaccacc	acacctggct	aatttttgta
106921	tttttagtag	atacggggtt	tctccatgct	ggccagggtg	gtctcgaact	cctgacctcc
106981	agtaatccac	ctgcctcagc	ctcccaaagt	gctgggatta	caggtgtgag	ccaccatgct
107041	ttgcctactt	atttttttaa	acaaaaataa	tcaaataaat	atacattata	tacattgcaa
107101	attagtaaca	agtcttgtgg	aagaataaac	acatatttta	aaatgctata	gtaaaaaata
107161	ccccacagag	caatgcatga	agtgggttgc	aataaatacc	aaattcagaa	atcagcttgt
107221	gtcaaaagaa	atgatttaag	agagctgaca	cgcactgaaa	tatggactag	tctagagaat
107281	gcttgaagaa	gggaatcaaa	gcaataaata	aataatcatt	tgtattattt	caccttcttt
107341	gtaagtgatt	aattgattaa	aggggagaca	gggttaagta	attcaagccc	ccagcatcaa
107401	tcagaggctg	aattctagct	tgtgagctac	aagctggtat	agagagctca	aaggattttt
107461	ctgggttgtt	tctcccaggt	cagtcatttc	tggctttgga	agctctaggg	ttgctgggtc
107521	tatgtgggca	tttgttcact	agtgaagctg	tcctggaatg	ggtccagcac	ctggagcagg
107581	ctagtctcct	aacatcctgc	gctgagcact	catgaacacc	atgtgggatg	catgtgtgag
107641	aagccctctt	ggtggcataa	tgacagatgc	tctgttcgag	agaggctagg	taaaggcaca
107701	tctaatgctg	aaaaactcgg	gagtatctct	cttttcattc	agcatgtatt	cattgagtgt
107761	cttccacagt	ctagctctgc	actacgtctg	caatacagga	atgaaaaatc	cctgctcgta
107821	aaaactcaca	tgggagagag	attaataacc	atcaactaca	ataggacaca	agtaaggctt
107881	atgatggcag	caagtacatg	gtattactcc	agtgcagagg	aggtctgctt	catcccggtg
107941	gtggtaatgg	ggtgggaggg	gtgaaggaag	cgcttctgaa	tgcggtgaat	tctgagatgg
108001	gttttgatgg	tgaaatagga	atgtgctcag	cagacatagt	gagggggcag	attatgcaag
108061	acaggtgcag	gtgcgagaga	gtgcaagtgg	ctcttgcaaa	gctaacagtg	gtttgtggca
108121	gggggcagga	ggtgagggct	gcagaggtgg	gcctgagcca	actgaagatg	ttattgatgg
108181	gttggatgca	gggcaatgac	ataatgagaa	aggcagaatg	aggggcaact	tttgccacat
108241	tccaccatcc	acttgctttc	ctagaaggga	agactgggga	ggccactgca	ttgcatttca
108301	gagactgttt	gtaaatgtat	gtatgtttat	ttatttattt	attttgggag	cttattaaaa
108361	gtatgtgtgt	ttatttattt	atttatttat	ttagggggct	tgaattactt	aaccctgtct
108421	caccctatca	cctaggctgg	agtatagtgg	cacaatcata	gctcactgca	gcctcaaatt
108481	cctgggctca	agcaatcctc	ctgcctcagc	ctcctgagta	gctgggacta	caggctaatt
108541	agtcatactc	agctaatttc	tctatttttt	ggagggatgg	ggtctcgctg	tgttgctcag
108601	gctggtctca	aacctcccaa	agtgctggga	ttacacgtat	gagccactat	gcctggccta
108661	tatatatatg	tatgtgtgtg	tgtgtgtgtg	tgtgtgtaat	atatatatat	atatatatat
108721	attttttttt	tactatcaaa	ttgctcctcc	tgagcccagt	ccattttctg	ggtacagggc
108781	tacagacaga	ccatctttga	aatgccagtg	gacagatgtt	atcacagggc	atgtttccac
108841	cgatgggtcc	atgcctcgca	cctggagcac	agcagtgagg	tggggaagtt	ggagaatatg
108901	agtgctgatg	tcttgtcctc	cttttcacag	ctgccgcgaa	tccctcagat	gaatcctatc
108961	ctcatccatg	catctgattt	ctacactcgg	ggtgggatag	agtttgagat	tggaaaataa
109021	tgcaagagct	ttacaccatg	acttatgagc	gctggctgag	gtatctggga	agatgtagct
109081	ggaacagatg	aagtctcaca	ggtgacactg	ctgtttctaa	atatttgaag	ggttttatac
109141	gtaacagaca	ggattagatt	ttttctgtat	ggttgtaaag	tatgcattgt	ccaattgagg
109201	gaaactatag	gaaaaactga	cttggttcac	aataaaaatt	attgtgccta	tcattcggtg
109261	agtgactaat	acgtgctgtc	atattatact	gagataatcg	aatcctttca	acaaccctga
109321	gaggtgcatg	cttttaacct	cattgtatag	atgcgcatcc	tcaggtgcct	ttaggtttca
109381	aacctatctg	cctgactctc	tctttccatt	gcattcaggt	tcacttgggg	aaaactattc
109441	tgtaatatgt	tttcccctga	tggagctttc	agaggtgaaa	tggaccgtgt	gctgggtgga
109501	taattctccc	tccacctgga	gatcactgcc	atgaatattg	taaaggggag	tcaaacattg
109561	cctgggctgt	tgaacccctc	agccttcaag	gcccggttta	aaggagagct	tctcagatct
109621	gctgtccttt	tataagtgag	ctggatattt	acactacatg	gcatgtgtat	tagcttctta
109681	ttgctgccgt	aacaaattgc	catagatcca	gaggcttaag	acagcacaat	ctatgctctt
109741	acagttctgg	gagtcagaag	tccactttca	ctgggctaaa	tcaaggtgtc	tgcagagctg
109801	tttctttctg	taggctctgg	gggaagaatt	tgcccttgcc	tttttccgtt	tctagaggct
109861	acctgtattc	cttagcttgt	ggtgccttca	cacatcttca	tagtgtgttg	ctccagcatc
109921	atatcacctt	ctcctcctct	gtagacaggt	ctccctttgc	ctgcctttta	gaaggattct
109981	tgtgatggca	ttaagcccac	ccacataatc	caggataata	tctccatctc	aagatccttg
110041	acttcatcac	atctgcaaat	cccttttacc	atgtaaggtg	acattgacag	gtctcaggaa
110101	ttaggacatg	gacatctttg	tgggacttta	cattcagcct	actatagcac	gcaaaggcta
110161	aagcatggat	atgtatagct	aggatggcga	gatcttccca	gacttaggaa	aattcactta
110221	aagaatgaat	tccaatctgc	atatgtcctt	cagatactca	gaacagattt	cattcaaatt
110281	gttctctagc	atacgcatta	ctagtaaaac	aaagaacagc	tccacagata	gaacaaaaaa
110341	agaacgctaa	cttatctttt	ctcacacagg	atggtagcat	tttaaaattc	agataaatag
110401	aatatgtgcc	cagcatcaaa	gtctcaggag	gtaaatgaaa	tgctgaagta	caaaaataac
110461	caagagaaac	tagtcacaaa	tcagacaaag	accaagcact	agcattgttt	tgcattactc
110521	caaactgcca	aactattgga	cttaggggac	ctggggaagg	gatgctcata	aagatagaga
110581	atttaatatt	agctctggaa	atgggatttg	ccacatcgct	aatccaactg	gcaaaaagta
110641	gcatgtctca	gagtccaaag	cctgataata	aagtatcacc	ctgcactgat	gtcagtttcc
110701	cccatcctgt	tttaggctga	cttctccagg	gagctatttg	agctctcaga	ttcaccatat
110761	aggaaactct	gaaaatggaa	tgcatgcaat	aagaatttgt	taactatcta	aataggtatg
110821	cattaccata	ttagacacta	agcgagatac	aaaaataagt	agaatacaaa	attctgtgcc
110881	tgaagggatt	ttaagataaa	caaaaagctc	cctgcaacaa	tctaaataat	agtggctcaa
110941	aatatcatca	tggtctctgt	gttctaagct	tccactcctg	cttgtcattt	atgcacccaa
111001	ttgaacaaag	ctatccgtaa	ataacaggta	tttgtcactc	agttgttgta	cattagctac
111061	tataggtaag	actgaagaaa	ataaaaaatg	gattgagcag	tagagcaaaa	caaataaaca
111121	aaacatgtat	tgagttcttt	ctgtgtgcta	agccttgggt	tcctgcagat	gaatagagca
111181	gggtccttgt	tttcaagact	ctgcagaaca	ttctttgcaa	gatctaccaa	gagatctagc
111241	tagaaaggac	caaaaacatg	ggtgaaacta	tcagatttta	attttttaaa	agctaagctc
111301	tgggttctga	atagagcatc	ttataagtag	acttttaaca	tggtcgaatt	atgtttctag
111361	atcttcataa	atctccccga	tttgaaaata	ctccttataa	aatgtatctc	ctctctgttc
111421	taaaattcta	taaaatataa	ttgaaaagca	cgagggtctc	atttaaaact	taaaactatg
111481	taagtgcaga	accaaaaact	atacaatgtt	attcaaatta	atcctgcaac	taaaatgaac
111541	tctgccatat	tacatgtata	agtgtgtaat	agcaataatt	atgaatactt	atgaactaaa
111601	tctgagagga	cttttttgtc	actttctgat	agtaactgac	taagtgataa	ataaataacc
111661	aaataatcag	cattatcatg	tgatatggtt	tggctgtgtc	cccgcctaaa	tctcaccttg
111721	aattgtaata	atccccatgt	gtcaagggca	gggccaggtg	gagataattg	aatcatgggt
111781	gtggtttccc	ccagattgaa	tcatgggtgt	ggtatccccc	atattgttct	catccctgta
111841	gtgaataggt	ctcacaagat	ctgatggttt	cataaagggg	agttcccctg	cacactctct
111901	ttcttgcctg	ctgccatgta	agacgttcct	ttgctcttcc	ttcatctttt	gccatgattg
111961	caaggcttcc	tcagccatgt	ggaactgtga	gtccattaaa	cctcttacct	ttatcaatta
112021	cccagtctca	ggtatgtctt	tattagcagc	atgagaacag	actaatacat	taggggccat
112081	ctgattttac	taactcgtta	agttgtgcct	ccaccaaatc	acaagttact	ataatccctg
112141	gaccttctaa	atggttcata	aaaagactaa	gccataatgt	tcaatttcca	tttgcagagg
112201	atctacagtg	cttgagaagt	tccaaggaga	actgagtgag	tgtgggctgg	agcattgaga
112261	gaacaggagg	gagctgggct	gagccttaaa	cgactcacaa	aggcgaaagg	agagtgttcc
112321	agtacagggc	acagcagagg	caaaggtctg	gcagcagatg	gcaatgacac	agttgagctt
112381	cctaaaagga	ccaaaggtgg	cattttggtg	agtagctgga	atggcagttg	aacagtggtc
112441	aggcaagtac	agtaggtaaa	ttccaaacat	ctagaaatga	gagattacat	tttttaaaaa
112501	ttttatttat	atttttggag	aggcagggtc	ttgctatgtt	gccccagttg	ctcttgaact
112561	cctggtcttg	agtgatcctc	ccacctcatt	ctctcagagt	gctgacatta	caggagtgag
112621	ccaccatgcc	cagccaagag	attaaacatt	aaaagaggaa	attaaaagag	tcaagctgaa
112681	gttctagtaa	ccatttccat	gaaccaaaaa	ttaaaaatac	aaaatggtaa	gaagtgtcaa
112741	agccatggat	gggacagagt	ctaggtcagg	cagcaggcaa	gggcatctgg	aattaaactc
112801	atatgggata	aaagggagaa	aataacattc	cagaggagat	ggtgaccaga	gacagtggtg
112861	gagggcaccc	tccatgctct	taaaaggacg	ctgaaaaaaa	attattgtca	actgctgcct
112921	ggaggctaca	gattatggca	actggagatt	catggaggta	ggaaagtaga	agcacagtgt
112981	gaagagtagg	aactgaccat	ccatccacca	gtgtcatcac	tccatctgtg	atagccccct
113041	ttccccaaag	taccagagct	ccaaatgacc	atgagaaggt	ctgtttccaa	acttggaacc
113101	caggtgcccc	gaagaggcag	ctggaaaatt	attgcaccag	gaagggtgag	gatatcgagg
113161	agaggaagat	tgagcaagtg	tgggctggag	cattgagaga	acagaaggag	ggagttaggc
113221	tgatccttaa	aagactcaca	aaagcaaaag	gacagaaaag	agagaaaaaa	atccatcaaa
113281	caagaagaac	cagcaaaaca	aaattccaaa	acacatggag	aaacctactg	ctaagagagg
113341	cagccaacaa	aataaaccat	caggacaaga	catcacatga	atgaagtccg	gacagagacc
113401	tacactgagg	atgctgaaaa	gagataaatg	aaagaataca	gctgtgaaca	gcaacaatga
113461	agcaaaagaa	ggtagaaaca	aaactagagt	ggatagatat	gagaaaaaaa	acaagtgcaa
113521	aattttgaaa	ttgagaaata	tagtaattga	aataaaaatg	aaatattcaa	aatacaggat
113581	aaactctaga	ctcaatcctg	tgggagagca	tatcagagaa	tgtgaagcta	tcactaagaa
113641	aatgctcggc	aagcagtgag	agatagaaag	atgaagatag	agacaggaga	tgagagagag
113701	attaaaaata	tatgtggtgg	ttcatgtctg	caacttggga	ggctgaggca	ggaggactgc
113761	ttgaggctgg	gaactagaga	caagcctggg	caacatagtg	agacagaaaa	tataaaaatt
113821	agctgggcat	ggtggtgtgc	cttagttcta	cctactcagg	aggctgacat	agaagggtca
113881	cttgagccca	agtgttcaag	ggtgcagtga	gctatgatta	caccgctgca	ctctagctgg
113941	gacaacagag	caagaacctg	tctttctctc	tctgtctatc	tatctatcta	tctatctatc
114001	tatctatcta	tctatctatc	atctatctat	ctatctatca	tctatctatc	tatctatcta
114061	tctatctatc	tatctatatg	caaaagagca	gttaagagac	atgggagata	gttaaagagc
114121	accaacatat	atctaatgag	agctctagga	gaagagagag	gaggaatggg	caggaaaaag
114181	gagtgacatc	aatactgtac	ctagatggaa	tgtggattct	gtgtgcctat	aaaaagagat
114241	aaaaacaaat	ccatatctat	tcacttcata	gtaaacctgc	agatatcaaa	gataaagagt
114301	acattcaaaa	tcccagaaca	cagaaaagat	agattatcca	gaacagaatg	gctgctaacc
114361	aaaaagctga	aggatagtaa	tgtgattttt	ttaaaaccag	ccaaagtata	attcaagagt
114421	aaaatcaaaa	taaagacatt	taaaaacaca	taaaaactaa	gaaccgtagt	aaaacaaata
114481	atgcactctg	gggaagaata	aatgcaatga	ataagataaa	agcaattata	aaatggaatt
114541	tgattaaagg	atagtaattt	tttttttttt	tttttttttt	tttaccataa	agtgacttta
114601	aaaagtacaa	aacagaattt	aaacaagaac	tgtaaaataa	gaagaagggg	tcattcttca
114661	gtgggttttt	aaaccatact	gactgacacg	tttgtcatgg	tcaagaggag	gatataagta
114721	ttgaaagata	aaatatgtat	tttttttaaa	aaaaattcag	cgttgtcact	aaaagactac
114781	aagcacaacc	tacaattatc	aaagccacag	agaaagaaaa	acatacaaac	agaaatgtgg
114841	aaatatttca	tcagaagaaa	aggcaaaggt	gtaaaaaaag	tcaaaaagga	tggtaaaaat
114901	tagtccaaat	atgtggttga	tcttaataaa	tgtagctaat	tcaacttatc	tattgagaga
114961	gaaagagaga	ttattagatt	ggatagattt	gataatagaa	tacaaatcta	ggtatatgtt
115021	gcttaagaga	ccacctaaag	ctacacagaa	agattaagga	tgaagagaag	taaaaagata
115081	aaccatgaat	atattcacca	aaagaaactt	cgtttggtaa	tattatcaga	caaattagaa
115141	tttaagcaga	agcattaata	gaaacaaaaa	aagaacgttg	cataatactt	aaaagagcaa
115201	aggaatcaga	acaatcacac	acttgtatac	ctctgagaaa	gtagccttga	aagagaaaac
115261	gcaaagactg	atggaaataa	aactatacac	cttggcattc	aggaagattc	atctgcagcc
115321	aggcgtggtg	actcatccct	gtaatcccag	cacttgggga	ggccaaggcc	agaattttgc
115381	ttgagctcag	gagttcaaga	ccagcctgtg	caacacagtg	acaccctgtc	tctaccaaaa
115441	attcttttaa	attatccaag	cttggtgttg	cacacctgta	gtcccagcta	ctcaggaggc
115501	tgatgcgaga	ggatcattta	agccaaggag	ttggaggctt	cagtgagcca	tgattgcacc
115561	actgtactcc	aatctgggtg	atggagtgaa	atcctgactc	taaaaaaaaa	aaaaagaagt
115621	agtttgcttt	tggcagaatg	aataaaatgg	agctgtgatg	tgtccttgag	caagacagga
115681	tgtgtaagag	cagaatttag	ggagggttaa	tctgatgacc	taagcaataa	aggcaggagt
115741	gaggaaacgc	taggtacaga	gattcgcact	ggcaagatcg	gcgtggtgat	ttaagagtcg
115801	gttaataaga	ccttgatcta	gggtggcaag	agatgaagtg	atcaaagggg	aaggggaatc
115861	aaaacaacag	acgtgaactg	aataactgaa	tatcaaggat	aaggaagaga	gagtaatccc
115921	aactggagaa	cggtggtacc	gtgagcagag	aagggaatga	tggctcgaaa	gcaagctggc
115981	tttcgggttc	atttgacata	cttagttttt	gatttactga	gttttgggta	acatccatga
116041	gatgactgtt	ctgagatgga	acacaggcag	ctgttggtgg	gaggagaggc	agagagccag
116101	tctcttggtt	gccatgctgc	cttctcctca	tgtctctggg	gtgtcctcta	atgccctgag
116161	gaggtagata	ctcttttttt	taaagttcca	gggtacatgt	gtaggatgtg	caggtttgtg
116221	acataggtaa	atgtgtgcca	tggtggtttg	ctgcacctgt	caacccatca	cctaggtatt
116281	aagcccctca	cgcgttagct	atttctctta	atactctccc	tccccccacc	ctcccctgac
116341	aggtcccagt	gtgtgttatt	ccccttcatg	tgttcacatt	gctcagctcc	catttataag
116401	tgagaacatg	cggtgtttgg	ttttctgttc	ctgcattagt	gtgctgagga	taatggcttc
116461	cagcttcttc	catgtctctg	caaaggacat	gatctcattt	ctttttatgg	ctgcatagtt
116521	tccatggtgt	atatgtacta	cattttcttt	atctggtcta	tcattgatgg	gcatttggtt
116581	tgattccatg	tctttgttat	tgtgaatagt	gatggaggca	gacactcata	ttcaccttca
116641	cttaaagaac	tggcaatgct	tgggaggcgg	aggcaggcag	atcatctgag	gtcaggagtt
116701	cgagagcagc	ctggccaaca	tggtgaaacc	ccgtgtctac	taaaaataca	aaaattagct
116761	ggacgtggtg	gagggtgcct	gtaatcccag	ctacttggga	ggctaaggca	ggagaactgc
116821	ttaaactcag	gaggcagagg	tttcagtgag	cggagatggc	gccattgcac	tctagcctgg
116881	gcgataaggg	agaaactccg	cctcaaaaaa	aaaaaaaaaa	aaaaaagaaa	aaagaaaaaa
116941	aaaataactg	gcaatgcaaa	aatttgtcag	gaaagaaact	aggggaattt	ccttagtaca
117001	tggccagaag	attccagcat	ctgtgagggt	gaaggcagga	aggtggttag	agcactggcc
117061	tgcccattct	cctgaagaaa	gatggttctc	agctcactgc	tactctgctc	ccccattcta
117121	aagtagtatt	tacgggattt	tatttttatt	ttgtcctgaa	tatttttgtc	actcatattt
117181	actacttttt	agtttctctg	cctattttag	aagtgaatgg	ttctggatgg	atgagaaata
117241	tcattccctc	caaagtccag	atatgatatt	gaggttttat	acttctgcac	aagtttctgc
117301	acatctgaga	ggtgcttggg	ctgaacctgg	atggccactc	tctgcaagga	agaggaaaag
117361	agagggacag	ctcctacaac	aagtgcagac	agtcatggtg	ggttgagtaa	gagaaggttg
117421	caggagagtc	acagagaggt	tggggcttgt	aaagaatgtc	atgaaagagt	gcagacacca
117481	acagaatggg	cgttgctgct	attatcagga	taagccagta	aatgccagga	aaaagatgta
117541	ccagagactc	caggagggta	agtactgctt	gaaggaaaaa	ggagaactaa	caaggatggg
117601	aaaacatttg	atttcagaag	ttgaagtctc	tggtgtgagt	tgaattaatc	agttaattcc
117661	tctaaggttt	cagagggaga	aactggctga	tggagggaag	agcagctcag	tgaaggatca
117721	acgagaagga	agagcgccca	tcacaaggca	gctgaaagct	gattcatcat	taggacgagg
117781	ttcaagggag	aagtcagtgg	ctgcccacac	tggcgcatcc	gtcatgggaa	ctttctatgt
117841	caaaaccctg	ccaatgaatc	atgaacattt	tagttgtgat	tcagattcca	cagctgagag
117901	ggtatagagt	aagctttaga	agtggaaaag	tttctgacat	attctggatg	gtaagaggag
117961	ggttaacttg	gcagtaatac	tgataaggag	gccaaggaga	aaagctgtta	gcatgttact
118021	gagtaattgc	attgaccaga	ggtaatccag	ctggatggac	aggaaggagg	ttttgttgta
118081	aattactgaa	ctgatggggg	cagggggagg	gtgaaattgt	gaaagtgtat	gacaaaggaa
118141	agctggaata	aatatttttt	ttttgaaatt	atttttaggg	aaggaaggag	aaatagctcc
118201	agataggttg	cacaactgca	caccaacacc	atgcacattt	agggaagatt	ttatcattaa
118261	ttgtctcaga	ctcacatgtt	taacatggta	tccataggga	agtggtgttt	gtgactccat
118321	gtggcaggga	agctgaactt	acttctgttg	gccacggtca	gaagagaaca	ggaatgtgag
118381	gaaggaagtg	gtgacaggaa	aaacaactca	aagtgatctt	tctgagacat	tacctccctt
118441	ccttaccatt	ttcaaattct	aaaaagtgca	catccattaa	cattttaaaa	atgcattgac
118501	atacatgcat	aacttcttga	tagcaaacct	ataactggag	acatttaaat	catgctagat
118561	atctgataaa	taacaaaaat	acatttttag	ttactcagaa	aatgatagtg	cacccgtttc
118621	caggaggctg	tacaagtctc	taacaatcca	cccctgcttt	cagacaatct	gtgcaaatgt
118681	gagtgccaga	gttatctcag	gagctacctc	tcctccagac	agcagaggta	atgtgaacct
118741	ctgtggtcca	ggcaggctcc	tggaagagct	gggttaccaa	tcctgggata	ccctctgcaa
118801	tcgccccaca	gaggacagtg	agaagagaac	aggcattaca	tttgcagatc	tttcttgaag
118861	catgagagat	aggaaagaga	gtcaactgta	tagacacaga	actgactaaa	atggaggtag
118921	gaggtagttt	aaagtactag	acaaaagctg	aagatgtggc	tggagaaata	tgtgtggggg
118981	ccagacgtgg	tggctcacgc	ctgaaatccc	agcactttgg	gaggctgagg	caggcggatt
119041	gcttgaggtc	aggagttcaa	gatcagcctg	gccaacatgg	tgaaaccctg	tctctactaa
119101	aaatacaaaa	attagccagg	catggtggtg	cactcctgta	atcccagcta	ctcaggaggc
119161	tgaggcagga	gaattgcttg	aacccaggag	gcagaggttg	caatgagctg	agatcgtgcc
119221	actacactcc	agcctgggcg	acagagcgag	actccgtctc	aaaaaaaaaa	aaaaaaaaga
119281	aaaagaaaaa	gaaaaaagac	atatgtgtgg	aaagtatagc	atcagcaaac	tgtataacaa
119341	caaggaacct	ggctgggaat	aaagtaataa	tgaatgaata	atatctaatg	ttcaaggatg
119401	acatgaatta	tgttgtacac	ttgggtacct	tactgttgag	catttcagtg	ctgaaaggcc
119461	ttggagtctt	tcagaacaca	aagaattgca	cttttgatct	gtggcaaaca	catctagatt
119521	ctattgaaac	attgtctata	tggttttgag	actaggggaa	tgctagaaac	acccttggtt
119581	caggagtgac	tcagaaatct	agtcccaggc	caagtgcagt	ggctcacacc	tgtaatctca
119641	gtgctctggg	atgccgaggc	aggtggattg	cttgaggcca	ggagtttgag	gccagcctgt
119701	gcaacatggc	gagaccctgt	ctttacaaaa	aataaaaaat	tagccaggtg	tagtggcagg
119761	cacctatagt	cccagctact	caggagactg	aggtgggagg	cttgtttaag	cccaggggtg
119821	caaggctgca	gtgagctgtg	atcacaccac	tggactccag	cctgggtgac	agaaaaaaca
119881	aagatacaaa	taaacaaata	accccataaa	aaggaggcaa	aagacatgaa	cagacacttc
119941	ttaaaagaag	acctacaaac	actaacaaac	atggaaaaat	gctcaacatt	acttaccatc
120001	agagaaatgc	aaatcaaaac	cacaatgaga	tccgatctca	caccagccag	aatggctatt
120061	ctgaaagagt	caaaaaacaa	cagatactgg	tgaggctgca	gatccaaggg	aatgcttata
120121	tatggctggc	aggaatgtaa	attagttcag	ccactgtgga	gagcagtttg	aagatttctc
120181	aaagacctta	aaacagaact	gctattcaac	ccagcaatcc	cattactggg	tatatatcca
120241	caagaaaata	aatcatttga	ccaaaaagac	acctgcactc	atatgctcac	tgcagcacta
120301	ctcaatatca	aagacataga	atcaatctag	gtgcccatca	acagtggatt	agataaagaa
120361	aatgtggtgc	atatacacca	tggaatacta	cacagtcaga	aaaaagaatg	aaatcatgac
120421	ctttgcagca	acgttgatgc	agctggaggc	cgttatccca	agtaaattaa	ctgaggaaca
120481	gaaaaccaaa	cactgcatgt	tctcatgttt	aagtggaagc	taaaaattgg	gtactcgtgg
120541	acataaagat	ggaaataata	gacactaggg	acttctaaag	aagggagaga	gagaggtaga
120601	caaaggttga	aaagccaact	attgggtacc	atgctcacta	cctgagtgac	ggaatcattc
120661	atcttccaaa	tctcagcatc	acaaaatatg	ctcatgcaac	aaacctgcac	atgtattccc
120721	tgaatctaaa	tagaagttga	aattatattt	aaaaaaatct	agtcccagct	ttttttcttt
120781	caatgaatca	aagattcatg	aaccacaccg	gatggacaca	aaaccttagt	tgtcaaaagg
120841	aagacatata	cgggggataa	aagcacacca	taatgctctg	gtatgaaaag	gaggagttga
120901	ttttagggac	acacgaagtt	ccctgtgttc	gcttggctcc	ttttacagaa	agaaatctgt
120961	aatggagctc	tacttataat	aacaaattga	taccagggag	atgcccatta	aaagagggga
121021	tgaagcaaat	ctcgtggaaa	aactagaaga	aaatagcagt	gtaaatgtca	cccaagtagc
121081	cagtgcattg	aaggcaatgt	tagaagcata	aggaatgttc	cctttctctg	gacatttgtt
121141	tattttgtac	tttatgggta	atgaaatttc	ttgggcattt	ttatttagtc	acaagccttg
121201	aaattctgcc	ctactgcaca	cacacacact	aagggagcca	taatacagga	taaaatgtaa
121261	atgtagtgtc	tttattagac	ttttctgtgc	taaaggtttc	ttttgatttt	ggataaccat
121321	aaatggggac	ccagaaaact	aggccaattt	tgcgtaagct	cacaggcagg	tgaaggctaa
121381	tgatgtaaga	ttctaaaata	agacaaagcc	atacagaata	tgagcagtga	aagcaattca
121441	aggagttgca	gttgtggctt	tcagaataac	tcaggggagg	ccccaaactg	tacaatataa
121501	aaaagtaggt	gagcaaatgg	cttagtcagc	tcagcagtaa	cagtggcaca	gaattgagtt
121561	cctgagcaag	tactttggac	aattagcaac	tatcttttgt	ccacatggag	attactgagc
121621	ttatgataac	catttcaaaa	tgggcacagt	gctggctagt	aagaagcatt	tagtctaata
121681	acaagagagg	tggcacatat	ataaatgcct	gcagattcct	gtcatgagtg	gagggccaga
121741	aatggcttac	gtacttgagt	ctgaatcaaa	agaaagtatt	tcacgggaaa	aggcatctca
121801	ctctcaatct	cccaagccaa	ataaggagat	aggttgctat	tacaatttgt	atataggaga
121861	aaaaacggat	agtggctagt	tggatggatg	atggatagat	ggataaagga	tggatggatg
121921	gatgacggat	gaatggatgg	atggtggatg	gatggatgga	tgatggatgg	atgatcgatg
121981	gatggatgga	tgcatggaca	gatggatgga	tacatacatg	catacttagg	atatataata
122041	aattgtatat	ttaatagtca	ttagcattct	aatatctatt	gggtgaacgg	aaaatttgta
122101	gaggaatatg	tacctacatt	ctttgcattc	atcagctaag	ttaattgtca	gcagactctt
122161	tgggaaaaaa	ttaggagcac	agctaaggtc	agtataggat	ggaatgtcta	aaggggtagg
122221	ggagatatat	caaccttaat	tgtgtacttt	tggataaccg	aatagggaga	ttcttagaga
122281	agaagatgga	gggttctcaa	aaatagatga	tgcatgtgta	taagtgttgg	tgtctgtcat
122341	caattaaaca	aaatccagaa	tgtaccaggt	tgagaatgaa	gaaaatgaga	atgaaaagga
122401	aatgcaatag	aaaagaaatt	agatcaaata	tagaaggaat	agtagatcaa	aattaggaaa
122461	aggtattcat	tgtccaaagc	atgtagatac	tagcacttgc	atagcattgg	atcctgttag
122521	ggttaaagaa	agagaatctc	atgctcccag	agctatctgg	tgaacgtccc	caactgtaca
122581	tgtggagctc	tgcaggcccc	acgtctgcaa	tagtactgta	gactacatct	ccgtccacag
122641	ccagcctcgg	catgttccat	ttacaccaca	tggagaaata	aaatgtattt	ctaatcggct
122701	ttctaataag	tactaattag	tccaggcctt	tgtgatccat	aaagagataa	agagtgagct
122761	tgcatccttc	catcaaagcg	ctgaagctgc	agctggcaaa	acctcatgct	gcttttcctg
122821	cctatcttaa	ggaagaaatt	gaaattagct	caatgaaaaa	atctcattta	gattttgcta
122881	atatgtatta	aaatccaaga	ggtaaaaccg	tgcaagcaac	tgtgacagag	ttcccaggag
122941	tggtctgagg	gggaccagct	tggggcagca	ttcgaacagt	ctcttccagg	aagtcacatt
123001	taaaacaaga	gcattaaatc	gtgacggatg	tacagcatca	gccattttga	tgcatctttg
123061	cattaaagga	cacgataata	cctaagaggt	ggggagaaag	tcaatgcacc	atattgatta
123121	ttatgaatac	aagagtttta	aagttagaca	gggttttgta	gttataagat	ccaaaatgat
123181	cttccagctg	aagtattatt	gcaaacacca	ccaagacaat	atccaagacc	aagggagaga
123241	attcagaaag	caggctgccg	ggcccacagt	ccttgtgctt	caatcaggca	ccaatccaac
123301	tccatcaaag	ttagacaaat	tatcccaagg	tctccaagca	ccttctccat	taagtgagca
123361	cagagacact	catggttttc	agtgcatgaa	aactccctgg	gaaacagctg	aggcagattt
123421	tctcttgttt	ctgcttttac	ctgggtctta	ggaaatgttt	catgttttcc	ccacagcagt
123481	ttccagaaca	caacatttcc	tcaaggctac	tctagggctg	tcccacttcc	catttcatgt
123541	ccaaggtcat	aaagtattct	taatgtaatt	gtaaccatga	tgtcttgtgg	ccaggcttgt
123601	cgtgattcaa	aacaagaagt	gtttagaaat	cgtttgccat	gtagtaacaa	agtctaacgc
123661	atctttcttt	gttatttgta	acaaaactgt	tccggaaggg	gatgtatagt	gcataggatc
123721	tgtacaacat	agtgctcaag	ccttaagtta	aaatgcatta	aaatgggctg	ggcacggtgg
123781	ctctcgcctg	taatcccagc	acttcgggag	gccgaggcgg	gcagatcatg	aggtcaggag
123841	atcgagacca	tcctggctaa	catggtgaaa	ccccgtctct	actaaaaaat	atatatataa
123901	aaaattagct	tggtgtggtg	atgggcggct	gtagtcccag	ctactcggga	gcagaggtag
123961	gagaatggtg	tgaacctggg	aggtggaggt	tgcagtgagc	tgagatcgtc	tcactgcact
124021	ccagcctggg	cgacaaagcg	ggactccatc	taaaaaaaaa	aaaaaaaaaa	aagcattaaa
124081	atgaaatgaa	tcttgaagtt	aaagacaccg	tcataggagg	tctgtgagag	ccagttgcta
124141	atagcaaggt	gggtatggag	gataaagagt	agcagaagat	gagataaaaa	ggtaggttac
124201	ccagatactg	tgatataaag	cattttatat	aaaaaggagg	gtcacacaaa	tattgtgaaa
124261	cgctgaattt	tatattgaga	gatgaaaaat	ccatctggaa	atcaaaaaga	gaaaaaaaaa
124321	aacccacatg	aatggaatac	atctgagggg	gtgaagagta	tggcaggggc	tgagaaaaga
124381	aaataatttt	gatagtgagc	tttttagatt	cctaagaatg	agaagagata	agcaggagag
124441	ttaggaggag	gaagctggag	tcctatccag	attcagcagg	aaattatttc	agcctaaact
124501	agagacacag	tggaagtgag	aaagaaagca	ctcggtttgt	aagatttctg	ttcaggaagt
124561	ggagtgaggg	tcccgtggga	atgagtgtgg	ccagaggagg	aaatggagga	ataatagatg
124621	attgcaagcc	cccaggtttg	ggaggcgggg	aggtgttatt	gacagtcagg	aagggaaaga
124681	aggtgtctta	aaaaggaaac	aaacagggtt	catttttagg	ttggttattt	gatgtatgag
124741	gagaaacatt	taaaagtcaa	gacttagggg	aggatgtgtc	taggaaatcg	agggcagagg
124801	ggattgctat	acccatggga	tgactccgtt	tactccacaa	atgtagaaga	aatgtcttca
124861	gggccaaatt	tcactggagg	tgaaaacatg	aagaacatga	gtacgattac	ctgggagttt
124921	agcagacggc	tgtatcatcc	agattttgtt	ttcagtgcct	ctacacctgt	gtaccttcca
124981	gagcattcgg	ttgattcatg	aggcttgtag	aatctgcttt	ttataaatta	aaggaataaa
125041	tctttggtga	ttatagtaag	gagataatgg	ggaggataag	gagagctcac	agatacaaca
125101	taggacaaaa	gtcagaattt	tcacatgtca	acacgaatga	aactttacaa	ataactacag
125161	ggaaggcaga	atagaaggga	gacaagattt	gggcaaggca	aacagagggc	tgattttgaa
125221	agtacagagg	aagtggtgaa	aacagtgtga	cagaggaaga	aaggatgaga	agaaatagac
125281	aagcgctgca	aagaaaatgg	aggaggctgg	gagcagtggt	tcacacctat	aatcccagca
125341	cttagggagg	ccgaggtggg	tggatcactt	gagttcagga	gtttgagacc	agcctggcca
125401	acatggtgaa	accccgtgtt	tactaaaaat	acaaaaatta	gttgggcatg	gtggcatatg
125461	cctgtagtcc	cagctactcg	ggaggctaag	gcaggagaat	cgcttgaatc	caggagacta
125521	aagttgcagt	gagtcaaaat	gacaccgctg	ctctccagcc	tgggtgacag	aatgagactc
125581	agccccctct	cccacccaat	aaaaagaaag	aaaaagagag	agagagaaag	aaagaagaaa
125641	gaaagaaaag	aaagaaagaa	agaaaagaaa	gagagagaga	gaaagaaaga	aagagagaga
125701	gagaaagaaa	gagaaagaaa	gaaagaaaga	aagaaagaaa	gaaagaaaga	aagaaagaaa
125761	gaaagaaaga	aaaagaaaat	gggcgaaatg	tctagagaat	cagaggtaaa	tgtttggagt
125821	aaatgacacc	cagatggcca	gggccacctc	tcctttttct	ggagaaacaa	aggcaacccc
125881	tatcctattc	ttatcagcag	ctaaaggcag	aatcgatgca	agaagattcc	acaggaaggg
125941	aagttcctga	ttctgatttg	tgtactagga	ctagaggttc	atatgagcag	ggaattgata
126001	aataaaatga	tcaataatct	agaagtgaac	ataatagata	gcttcaagag	gcacagatgc
126061	gcaagcctat	tgctgaagcg	gcatcaaaca	tttctgagat	tcaagaaaat	aaccatttgg
126121	gtctcatggt	gggggcctgg	ggatgctgga	atttaaataa	atgtcccaga	tactgatcca
126181	gagagaaaag	caagatttga	agatcatcaa	gagaaacaaa	tctgtttacc	tccattaacc
126241	tccaccccct	tttctccgtc	accctcttct	ccacatatat	acggggaaaa	agactcaagg
126301	gggtcccagc	aggtggtgat	ttcttgaatg	gtgttcattt	tctacttgca	tgctgtggcc
126361	ttattttaaa	tttgaattac	tttgtaagca	ggaagaaaaa	tcattatttt	taagtcatta
126421	agaaagccag	ataactttga	aaattaagcc	aaatgaaaga	tcgagctatc	ttaatgccca
126481	aatatttcag	cagctattcc	tctcaaaaat	cttttttaat	gttgttccat	acgaggtgtg
126541	gcatttttgc	caggaggtaa	ggattttcag	ggattatgat	ttcaaaatac	taaaaacaac
126601	tgctatttat	taaaaaaaaa	atttttttcc	tccatgacag	gtagcatagg	tctgggatga
126661	agaaagtact	caatagctaa	ttactgggtg	gagtggaatt	ttaaatagag	ttgaattata
126721	gggatatata	ctctgcagag	agcaaagatc	tggcatctat	tcctagaaaa	tctcatggag
126781	gctcttctct	ttgggtggga	ggtaacgatt	ccctgaagat	catctcctat	ttgggaaggt
126841	ctctgtgtgt	gacctctttg	ggcaaatata	ccttctggtt	ttctaagcca	cacttgattt
126901	caaatatatt	atcaagtctt	cccacaaacc	ataggaatgt	tccagcaatt	tcagcatttc
126961	tgacttctga	acagtatgac	tcagcctgcc	ctgagaactt	ggaagcgaca	ctcaagccct
127021	ctgtagatgg	tgtgtgtgaa	gctctggttg	ggaatgaggt	cgctggagat	gcccatagca
127081	cagcagagct	ctgcgtgggt	catctcaact	ccctcacctg	cttcctctgg	actcagcaca
127141	ggcttagcta	gaaccctggc	aattggtaac	tggtgttttg	ctcagaggtg	ataaaatact
127201	cccttttttt	ggcagtgtgc	aggaaagctg	ggactggtgg	ctggtgaccg	gcatgcctgg
127261	gcccatggct	gactgccttt	gagtgggtaa	agaaatcaga	ggagttggct	caaaaaggca
127321	gaaatgagga	gtgtcctcct	cttacttaca	tgaataaaat	tcaaaatggg	cagcagtcct
127381	cttacacgtg	cattctattt	ctttgaccct	gtgtgtgaca	gatcaggttc	cttcctgctc
127441	cagacaaatg	gggggactgt	tgtccccaag	aaaatgctct	tgaggatgcc	cactccccac
127501	ccacagatgg	cactggtcgg	ctggaggaag	gggaggctgc	tccggcctca	ctgccatagt
127561	tacttgtcta	tacctgtatg	ttttctttcc	cttgtgtatg	tgtgtgtttt	cctgttcatt
127621	tccataaata	aaatgttctt	tctcagctgt	atagctgcct	cccctgatta	attcctgccg
127681	tggcctcttt	gtaatggggt	ttcttctttt	gctgaaaaca	gcaggcatct	gcttttggag
127741	ttgagttaat	gggggatgga	agggagttag	ccaagtctcc	gtgggctctc	tgagaatccc
127801	cacaacctcc	ttacaaatgg	cttccatttt	cggctgattt	ctcctgattt	tgtttatgtc
127861	tcacaaaggt	agaatatttt	acaggccact	cagaatttca	tgcaacagcc	cacactgggt
127921	tgaattttaa	gtagtatctt	ccagggaacg	cgggggtgtc	cagttaccat	ttctgccatc
127981	agagcctggt	tggtcttttg	ccatcagcac	aagaacaaag	tgtcacattt	gctttttttt
128041	ttttttttct	tcacaagatg	gctaccctga	tctcaccatg	agcgttatta	tctgctggtc
128101	ttcctcgaat	gcctacgtac	aatagattgc	atctatttaa	gtatccagat	ccttttggag
128161	acagggcctt	cttctgacac	acacaaaaag	agttttcaga	tggcagatcc	gcaggtagta
128221	attttaatag	ccactaatgt	gaattaataa	ttctaataac	ctcatttcag	atgtgttatc
128281	gggacgcagg	agagggttgc	catggaggct	gtattttatt	gctcacagct	gtgcaaactc
128341	attttggccg	gcagcattcc	catgtctaac	ctctcctttc	attggtttgc	accatgtcag
128401	gcagtgtgga	tttaacaaga	acggccaaaa	aaacttaagg	aaaagttgtg	atctcaagac
128461	tctaagcaaa	tgatgctgat	aagcaacaat	aagagagccc	agtgctttag	aagagaattg
128521	tgcagttata	tattcatgag	attaaatcat	tgctttggca	catttatcaa	tatcaatgtc
128581	caaattataa	tttgtcagca	attccaaggc	acgttcttta	agtgctttgg	ggcataaaca
128641	atattcctta	ataaactacc	ttagggatta	ttgcccccta	taagattccc	aaaagtacat
128701	taatttataa	tctgaggcct	gtaactgaca	acagaccagt	aaacgtttag	ctaagtgtgc
128761	ctcccacatt	ccctggtcct	acaatagtgt	tttacggatt	tttttttcca	tttaattctc
128821	acagcattcc	tataaggttg	tcatattggt	ggttttaaaa	cctggacaca	cattttttga
128881	tactcccttt	gagaggtgga	gactgtattc	tctccggttt	catctgggca	ggtttgtgac
128941	tgctttgatc	aataaggtac	agcatatcag	ccaagtacag	catatgtgac	actaagtgaa
129001	caccagggtg	tcttaaaagg	ccatgcatct	tctgtgttgg	tcattgggcc	atttgctcct
129061	agaaccctga	atcgtcatgg	gagaggctgg	atgccctgag	gctgtcatgg	tgtgagggag
129121	cctgggcatc	tctagatgct	gcgggtgaca	gcgctagctg	agccagcctt	ccactgaatt
129181	caacccaacc	caggtcccag	acacgtgaga	ggtaaagcct	gcaggcgatt	ccaacacctt
129241	gtatatttcg	tctctccaac	tgaggcccca	gacactgtga	agcagagaca	agccatcctc
129301	tctatggtct	gactgaattc	ctgatcttca	gaatccatga	acataatgaa	atcgttgttg
129361	tcttatctct	aggttttggt	gtggtttctt	tgttatgcgc	caataggtaa	cgggagcacc
129421	aaggacgctt	agatgttaaa	cagcttgacc	atgtcccaca	gtaaatagag	gcctgagatt
129481	taaaaccggg	tctgttagat	gccaaatctc	aaactctttt	taccataaaa	ttataagcac
129541	cctaagagaa	gtctataaat	agtgttataa	aaacatgaga	aacaagtatt	tttctttctg
129601	tccatggtca	ttagtgtgga	ctcatcgtgg	gcttgccaat	cctaaacacg	ggaaagctgt
129661	ggaaaacatg	cggtgatctt	taattaaagt	ctatttttta	aacccacccc	tgtgttccta
129721	ccaaattgtc	atgtatctga	tttgaaaagt	agccaactca	ttgactttaa	cttgcatctg
129781	aacccatatg	gcaatctgga	actcaacatg	aaacccccaa	attctgttca	gctctggttg
129841	ctccatttga	agccaatcat	gggaaatgct	taacagcttc	tcttctttgt	tgccatttaa
129901	atactgtctt	ctttgttcat	tttttttttc	ttaagttcta	catctttaca	aggtttctaa
129961	acttttacaa	aacttggcct	tttgggtctc	aggactgtga	aagaaatgca	gacttgaagt
130021	tagaccatac	taccaacctg	tcagaaaagt	ctctggtgag	atccattcag	aaggttgttt
130081	gttgttcagg	ccgggcactg	tggctcatgc	ctgtaatccc	agcactttgg	gaggccgagg
130141	caggtggatc	acctgaggtt	gggagtttga	gaccagcctg	gccaacatgg	caaaacccca
130201	tctctattaa	aaatacaaaa	attagccagg	tgtggtggtg	ggcgcctgta	atcccaccta
130261	ctcaggaggc	tgaggcagga	gaatcacttg	aaccccagag	gtggaggttg	cagtgagcca
130321	agactgcacc	actgcactcc	agcctgggcg	acagagtgag	actccatctc	accaaaaaaa
130381	aaaaaaaaaa	aaaggagggg	ttgttattca	ataaacccag	acctcatttc	ccttccctca
130441	tttcctttct	accccacata	gggctggaaa	aaacaaaaaa	caaaaacaaa	caaacaaaca
130501	aaaaaaacaa	ggtaaggcta	atcttatatt	cagttagagg	tttccaaatt	ttaggaaaac
130561	aataaaatgg	agataattta	ataaaaacct	ccaacctcat	ttggagctga	Rctctaggca
130621	acgtatacct	gcactttgaa	aactcttaca	ggcagagtca	agatttttac	ataaactcca
130681	ttttcctgga	acaaattgac	ttaactttgt	gaagccttcc	ttataatgag	aggtctcagt
130741	gcaaggtcac	aggtgacagg	actgcttctg	taattagtca	ctaaagcatc	cagaagcctt
130801	tgggaataag	ggattttcct	tgcgaaggag	gcttatttat	taactgttaa	ttataaSttc
130861	tcttgtcagc	ttctctgtgg	atttggtgtc	tacaaagaaa	gctgagggga	aaaaattata
130921	agggcttctg	tgagaagcat	aaatcagaag	ccatttcaca	gtgccctgct	acaagtagcg
130981	tttgggactc	tcagatggag	taacaggcag	atgcatttgg	tccaccatag	ttgcatagcc
131041	tcagggctga	gacacccagg	tgactgtcac	agtcctttag	ggctgccact	cacgtttggt
131101	cctgtggaca	tggcaaacga	gagctttgct	ttgcctgatt	gctgtggtgc	accagcaagc
131161	ttccagggag	ccccaagttc	tccattcagc	cttgcatccc	atacatttca	tttgatataa
131221	gttcttatct	cttggactgc	cctgggtagg	gtcactgggg	ttggtgaatc	acgKtggcct
131281	ttctcctgca	tagtggttcc	tatgacaaca	gcaagtgaca	cttgaaatgt	aagctacctg
131341	gagagaccca	aagaccacac	aatatcatct	gtgtggatgt	gataagttgg	cttcctttaa
131401	gtggcaagga	aaggtaccta	aatacttctt	cactgacctt	ttgtggttgt	tagggtatat
131461	agtttttcag	agaaagaaaa	aatgtcacca	ctattttaag	aaatactgag	catgacatta
131521	gatatggaca	gcttaatttt	tctacatggc	tgtcttcttc	atggagttcg	tggtataatt
131581	ctttgcaggt	tatagaagta	cataatcact	tttgacaaat	agagatacgc	atatttcccc
131641	actagcaata	agtggattag	atgatatttc	agatcaagac	aaccctaatt	aaattactcc
131701	taactttact	ggcctctgtg	gattgatctc	tctttgacct	tcatagccca	tcagaataaa
131761	tgaaaagaaa	acattctaat	attttttccc	attaaaactt	tttcatgaac	cttcatatct
131821	gtatactgca	ttatatacat	atacatcaac	tgaagccaat	aaatgtttgc	ttgttcttta
131881	tgtctttttt	aaagcctgta	acaatataaa	ttagcattat	gtcaaggaac	tacattatta
131941	gattactgca	aagaaagatc	atttaaatta	catttttaat	gtttccacat	ttattttatg
132001	agaaaaaaat	attttttaaa	caaatatcat	ttcttaagac	aagattgtaa	atgtatcctg
132061	atgtctttat	cttgttaacc	gtaccagatg	aaagcactgt	ccaacataat	gaacaaaaga
132121	cattttcttt	aaatgggcaa	agtattggaa	attttcttta	caacaccatg	cactacaaat
132181	tatcttccat	aaagaggaat	cttttttgct	tttcatgagg	tgtctttgtg	gtaaacactg
132241	taagggggca	tttttgattg	tttgtttttt	gccatttgtg	aaaaggcaaa	gtttatatta
132301	catattttct	ataaaaagtg	tggatatatt	atgctgtttg	tttaaaaaat	ggtatttcac
132361	tgcatggcaa	gagtgccctc	ttttaaataa	gtacaaaatt	caaaaattgc	aagtcacaga
132421	ctactagaac	tcacaaaact	tttttcttct	tttctctttc	tttcttctgc	cccctctttt
132481	cattacctta	tacaagacag	cttatgattt	tgttaaaagt	gatgactttt	ctagaacatt
132541	caaaatgtca	tcctgtttgt	gaccgttttc	acagaaactc	tccagggctg	tctctaccat
132601	gtaatgcaag	gtactcccac	catgggaata	atattttaaa	gttctcctct	ggtagaatat
132661	tcatacattt	ttagcaacta	gaagcaagta	ggtcttattt	agttttacat	tattcacagt
132721	ggttggttat	tacaaagcct	tgcacatagg	aggtgctgaa	taaatatttg	aattaacttg
132781	gatgattgtt	ctgaccaata	ggatgggtga	tttggtgctt	tttgatgata	ggaatagata
132841	aaacacagtt	caaaaatcat	gcctggcgat	tttgttgttt	tgatgaataa	atctcagtca
132901	acgttcatct	acctggttaa	tcacatggag	attagccttt	ctgatgcaga	tacacagtca
132961	tcttgatcat	cacttgatgg	taccagacat	tttgatgggt	ttcctcatca	ccattaggta
133021	catccagtct	tttctgtctg	ctagaaagtt	ccttctggct	gtatacacac	acacatgcac
133081	acacacatac	acaccactca	aggtttcctg	agcctgccca	ttttctgttt	taattcttaa
133141	ttcaaggaca	aaggataaag	gttgattgaa	taaggaaagt	catcttttgc	tttctgattt
133201	tttttttttt	gatttggcat	tcttacatca	tgctaatctt	gaagaagtat	caaatcctct
133261	aaaataaatt	gtggcaaaga	aacatcttct	gtctctttgg	ctccttccca	gggaagtctc
133321	agaagtccta	caattcctca	cagtcacagg	gtggtctctg	ctggaaagga	ttgtattgaa
133381	catagagtct	ggcaagcgag	aggttaaata	acaattattc	caatgtgggt	aaagtcacag
133441	tcaacatcat	taaaattgtt	tttttccccc	aatacctttg	tactcattca	tgaataaaag
133501	tgagttttat	agcagaagta	attactcttt	cttatcctaa	tgaaaatctt	aacaaactaa
133561	taaatgtgta	accccttcct	tgggtccaaa	tgttgttttt	agttactcta	tacttgtgcc
133621	tagaagaacc	aaaaccaaaa	taaatgactt	atcttttgtg	ttatatactt	cccccaaaat
133681	tatatcccaa	agatcattta	aatactcata	acatcacttt	tgaaaacaaa	ttaagttcca
133741	taacctctta	gcgttcttct	attttcctgt	cttatgatgg	cctgcgcagt	tcaattctcc
133801	ttttgttttt	tctcttccta	tccagggaac	ctggactgcc	tcctacaacc	tctttctctt
133861	tcccctccaa	aaagcaattg	aaaacatgtt	tgtttgctgc	ccagagggaa	ttcatccatt
133921	taacataaga	ttgcacagga	attccccaaa	tagagaacat	tcaacatttc	ctatgatgtc
133981	aacaggaggc	caaactccag	aaagagcagc	cggttcttgc	ccgatgccca	tccttgggtg
134041	ggttgtgtct	gagtgctgtg	caagctccca	tctggcacat	ttcttctcac	tgagatattt
134101	ccactgttca	ttctctcatc	cggcctattc	tcctattcac	ttgaataatc	aatagcagca
134161	acagcctaat	tacccacatc	atcctcgctg	tgctgaaatc	atgagtacga	agggtgcaat
134221	tgcttcctta	ggaattcatt	gccttcttaa	caagaaccaa	cgcaaactgt	cttacgactg
134281	gcatctctcg	agcagaggct	gggagctgat	gaagtagccc	tggtctcacc	tcagtagcaa
134341	atattacctg	cccttctcca	cctcccttca	aactgccRac	aacaccaggg	ctggcttcct
134401	taaaatgtac	ctttgggatg	cccacgccat	atggcagctc	tgagaatgtc	accctatgct
134461	ctagggtatt	tttccccgta	gcttacacaa	attgtaaatt	attatccata	aaataatggt
134521	aaagagagac	aagggcaagg	aaaRgatctg	ccgtaaagcc	tccattagca	aatgagattg
134581	gctttcctat	tcatgtgaaa	agttcaagga	ggcaatcttg	ttaaacagcc	attttgcata
134641	aagaaataat	atgccattat	ggaccttttc	aaataacttt	gatgttttcc	agaacaattt
134701	attaatactg	tactttggag	aaataagaga	tgaagtctca	ctagagaata	aaatcggtgg
134761	ttgttgggca	gttggtcata	gctcagcagg	tttcatagct	gtctgaaaca	catttccgtc
134821	ctctgctaga	agtgcttgat	ggcaaaattt	ccccccaact	caactcccct	tccccgtttt
134881	atcttgggat	tatttgaatc	agagaaacag	tcctgatctt	cacttctcta	tacaataagc
134941	aacagtagta	taattgcaat	ctgacttctt	tcttttttcc	tctccctccg	tcaataccca
135001	ctgaccttcc	taagactagg	ggggaaggag	agtgataggg	ttatgaccta	ggtttataag
135061	aggcatgtta	atgatttacc	tatttgaagt	aagttacatg	aacaagactc	ataatgtagc
135121	tccttggctg	gattcgtacc	tgcctagatt	cacctgtgtg	ttgaactcac	acaaaccact
135181	tcatactaga	tccttgcctt	tatggaattt	gcacagtagt	gcctgcttct	aagtgtccca
135241	ctcagtcttc	tgttctgttc	tcctaggtag	cttacatgaa	agaagacggc	atccaggcac
135301	cttcagcttt	tctgtgtttt	gggtactttc	caagaagtga	ttacttatca	tcgtgttatt
135361	aggttggtgc	aaaagtaatt	gcttttttgc	cattgaaagt	aatggcaaaa	ccgtgattac
135421	ttttgcacca	acctaataat	tactgtattt	atgtgagtgc	attctgaaga	atactagttt
135481	tgcaaggtgt	cagagggatc	cgttgccaag	cacatttgaa	aaaccctgga	aaagaaagtt
135541	aaacaggtac	tttggccatg	gaaatgtaat	tacaaagctt	ttaatacatg	cattcatttt
135601	gtgcaacttc	tccaagaata	tataatttgt	tgcatttcgc	aaacttactt	gacttttgtc
135661	aaacatgctt	tctgcattaa	aattacagaa	ttacggaatt	gtgaattaca	gagggagaag
135721	aattggtttt	cctcagcctc	aaatatcata	tatgatccaa	ggtgttttga	gaaccagtca
135781	ataggatggg	aatggtatgg	tataacctct	agattctaga	gatcctctct	catagtggtt
135841	tcgttgaggc	aagttgccat	attggagagg	cccatgttgc	aaggtgtggg	gaacgcctac
135901	ctacctgcca	agccaaaagc	cctccagaga	ccgaatcctg	ctaacaacta	catagtgatc
135961	cttccctaRt	tgaggcttcc	gatgaaactg	caagccctgg	gctagcacct	gaattgcagc
136021	ctgtgagaga	caatgaagca	gagaatcagt	gaggccatgc	ctagatgcct	gacccacaga
136081	aactgtgaga	tcataagaat	tttaagtcac	aaagttttgg	aggtaatttg	ttatatggct
136141	atagctaacc	aatacagatt	ttggtttcga	gtctagaata	atgtgaatca	ttgtctcagt
136201	aggattaatt	tggaaaatta	taattgaagg	tataagtcct	gggcagagtt	ttgaggaaga
136261	aaaacacatt	actcttcttg	ggataagaga	caatattcca	gttatgaata	aaagaatgta
136321	caagggctta	taatgtcaat	cattgtggag	aataattcct	gagaatttat	taaatgcatg
136381	gccctatggg	gaatagaaaa	atgaatcatt	ttttcttgtc	ctcaaggaac	tttctcccta
136441	gacaagaagg	aaaataaata	attgagcatc	tattgttaaa	agtagaagta	aaacaaagat
136501	acaaagagct	atcgaagcca	tactcccata	tatgcaaatg	agtgagatta	gtccczaacag
136561	agtggaagta	gagaattaag	aaagtttcct	tggaggaaat	gccaatcgaa	ttgtccttga
136621	ggagtagaaa	ataaaatcat	agtattttaa	caacaggtgg	aaagggtgaa	caaagtcatc
136681	tcctggggaa	aggagaacat	aagaaaaggt	tcagatataa	ggaggtatgg	ggtaaattcg
136741	gagYaagtac	agcaagtatg	tgtagggcat	cgaatagagc	atctttcaga	agaaaacaga
136801	aaccaaaatt	gaatagccaa	atgattttgt	tttatactgg	gtgggttttt	atttcaacaa
136861	gttatgttaa	gtgaatcaaa	atttggctac	cagaatgaaa	aaattagaat	ctcaatttcc
136921	atcattccgg	tttcagctct	aagcctgaca	caggcaatga	acacctcttt	taggtaaacc
136981	agaccactct	ttttgcaaat	ggcctcaaga	ggtccctgag	tttRaSccca	tgacttgaga
137041	taacatgaga	ttgaaacctt	ccaagcaaaa	gaccatcaaa	cccttagtca	cctctagata
137101	agattccaca	cgatcccttg	gaaacttctt	ctaatgtttg	acaactttaa	cagttagaca
137161	gcttgtcttg	gttttgtatt	tcttaatgct	taattaccca	cttttaaact	gtgaagataa
137221	atgtaagtct	tctctggaaa	gttctgagtt	tctctgactt	ttcttcagag	gtcctttggc
137281	taagtcatta	ataattgtca	tgttctcctc	tggacctagt	ccaaattttc	tatgtctctt
137341	tagtagtaaa	gaccccatct	tggcagagca	cattaacaaa	gggcctaaca	tatgacaggt
137401	agggttaaaa	aatgacttgg	ctttcacatt	ttatattccg	cacacgtgac	atcatgtgat
137461	gtttacctcc	tagtgtcagt	accgtgtcat	gggcccacat	ttgtcctgtc	tatcatgact
137521	tccagggcta	cagataagtc	ttggctctag	gaacagctca	ctaaacttct	ctttgagagc
137581	ctaaaattta	ggagatatta	cactacacag	gggttgtatt	ggaacaaata	cccgatatga
137641	ttagaatttt	aatgttcgaa	cactgaaaaa	gaagcagcct	tggccgggcg	cagtggctca
137701	cgcctgtaat	cccagcactt	tgggaggctg	aggtgggtgg	atcacaaggt	caggagacca
137761	agaccatcct	ggccaatacg	gtgaaacccc	atctctacta	aaaatacaaa	aaaattagat
137821	aacatgagat	tgaaaccatc	caagcaagtg	ccagctactc	gggaggctga	gacaggaaaa
137881	ttgcttgaac	ctgggaggcg	gagattgcag	tgagccgaga	tcgcaccact	gcactccagc
137941	ctggtgacag	agcaaggctc	tgtctcaaaa	aataaaaaaa	gaagcagcct	taaagctgcc
138001	ttctcttggt	aagttagtat	gaacttacct	aagaaccttc	atagacatta	tctttttgtt
138061	taagagacag	ggtcttgctc	tgttgctcag	gctggagtgc	ccccaactct	tgggctcagg
138121	taattctgcc	tcagcctcct	gagtatctgg	gactacatgt	acatgccacc	atgcctggtt
138181	aatttttttt	ttttaattta	ttttttagag	atcgggtctt	gctatgttgc	ctagggtggt
138241	ctaaaaatcc	tggactcaag	ctcttcacct	gcctctgcct	cccaagtagc	tgggattgca
138301	ggcatgagcc	tggccgtcgg	cattatcttt	gacagcctca	caaatatcct	gccaaggatg
138361	ttaagtggtt	cctaattcta	tcattgtttt	accattgagc	aaactaatgt	tcagatatgg
138421	tcacttatct	acataagcaa	attttaagtg	gtgaacttct	acaaatcgaa	tctaaactaa
138481	agaaaccctt	gttggacctg	ttttgcttcc	agattctctc	ctaacttatt	aaggtatata
138541	agccccaaat	cactaataag	aaaatgcaat	ttaattgtaa	tgtagtaggt	gaaatgtagg
138601	cacaactgct	atttttgaat	aaggatatga	atgagaggat	caatgaagtg	tgtgtgtgtg
138661	tgtgtgtgtg	catgtgtgtg	tatgcatgta	cagcacagcc	aacaagtggc	tggacaagac
138721	actactcagc	tggcaccatg	caaaaagaca	cctgtaaaat	ttctgtctgt	ccccttttca
138781	gacaaattca	gtctctctgt	cctgtcccct	taatacctaa	aagtgtccat	cattcttggt
138841	accaagtgaa	gagctctgta	agccttcctc	tcccttgaac	caggggacct	ttcactctcc
138901	ccaaatggtc	cagtatttgg	cagtaaatgc	caacacatct	tgctgtaaat	atctcggtgt
138961	gtgtgtgtgt	gtgtgtgtgt	gtgtgttgtg	tgttgtgtgt	gtattcctag	gtctgggttc
139021	ttggtggaag	tgcccacctt	gccagaagaa	actgttctta	actccacctt	tagaaattaa
139081	acatttgttt	ttaaacaaac	gaaaaagaaa	aaaaaaccca	aggtgtacaa	ctgtttaatg
139141	gctaaggaag	tcctagagta	cacatacctt	aataccagtt	tctttctatg	aaaccataga
139201	agtgatagtg	aaaattaact	gggaactctg	gtgcttggga	atcacatcat	tatatgatta
139261	tactgttttg	tcattataaa	attatggacg	tcattgtgta	gtaggaatcg	ggaattgtac
139321	aaagctagac	agcaaattat	attctaagta	ttccctttgg	aatcaattaa	agaacatctt
139381	taacaaatta	ggccctttgt	ttcatcatta	gaaaggaata	tataaacagg	atatttaggc
139441	aatgaaatat	tttccattca	aattaattat	agcaaattag	ctagagaatc	tataataaat
139501	tgcaaagttt	gacaccttat	gaacttatta	aagtgaaagc	tttcctctta	gcctttaaat
139561	tattaatttt	catggcctaa	aattataatt	taatagtttt	attggcatgt	gataattttt
139621	aaattacaag	actatcgtca	tcccactagg	tctttctatg	cataactgaa	aattacttac
139681	agcattttag	tagcaatgga	aaataatgaa	tgaatgctca	aatctgattg	gttacataag
139741	tcatttttca	gctcttttgc	taaacacaga	taaaaactct	tttctcaata	aaccacaaat
139801	ttgtacctaa	aaaagaaaaa	ctggctattt	tattactttt	gcctattttt	gtgaaaattt
139861	cacgttgtat	tgattttttt	cttttctcta	ttctttccct	tgagtcaaac	tcttgatttc
139921	tgccgtgaca	acaggaaaaa	agaaagtgca	ttcagcattt	ctgtccaatt	cctccctttc
139981	cctttacagc	aacactcctc	gaaagaattt	tctataacag	atctctatgt	cttacatgat
140041	tctagcactc	agtcagccct	cgccagtcag	gtttctggcc	tcatcatcat	cctctgaaac
140101	tgctcttttc	aaagtcacta	atggccattt	tttttttcct	tctcttactt	gacttctaag
140161	tatctttcac	aacacttgaa	tggttcctgt	ttcatgaaac	gccgtctgct	cttgacacca
140221	ctctcttcct	cctactttca	tggctacttc	ttcctagtct	cctttgttct	ctccttttcc
140281	tctttcaata	tccaaatcat	aaccccagct	ttcttctctt	ctataccttc	atttcttccc
140341	tagataatct	taacaagtct	cattgctgta	agtatcatct	atatgataat	gaaacctgaa
140401	tctattacta	ctgtcttgac	ctccactggt	tgtctgactt	ctacatttaa	atgactccta
140461	ggctgtcacc	ctggtgttca	aaacagaatt	atctacttct	tcctaaaaac	gtattcccag
140521	tctgcctctc	accagcacac	tattccagta	tccccccagt	tgctcaggcc	aagaagctag
140581	atgtatttct	tgaatcattt	tattcccctc	acttcctatt	ttcaatYcgc	gccaagtttt
140641	gtcaactcta	cttttaggac	acatcccaaa	cttgcctgct	tttgtctatc	atctgctact
140701	cccacccttg	tctctaagtc	gtcatcatct	cggctgcaac	gttgctagag	ccttcttagt
140761	ggtctctctg	attctaccct	tgtcaccctc	caccctgcaa	ccaccctgag	aaacccttct
140821	ccacacagta	gccagagtaa	cttactgaat	cagacgttct	cactcccatt	tctaaaattc
140881	tccgttaaat	tccctcgcat	tgaaaatcaa	ctccaaagcc	tataccttgg	cttttgaaga
140941	tcacttgatc	tggcctgttt	gcctttccga	gctggccttg	cacctttctg	ttctactctg
141001	tataacaaca	ttctatgtgg	caggggctcc	actggccata	cacatgagtg	aagggcggag
141061	cagagcccca	aaggggcccc	aggataagcg	tatgttaagc	tatgaagatt	tttgaggttg
141121	gctgtttcta	cggcataacc	tagcttgttt	ttgctggtac	agggaatcat	ttacatattc
141181	gttcacaaaa	tacatatttc	ttgaatgtgt	agcatatgtc	agacattact	tttggaataa
141241	tacctctaac	tggggataga	caaatttcac	tctctcatgg	ggtttacttt	ctaatgaggg
141301	gtgcatacga	taaacaagaa	aacaaataca	tgaataagat	acttttagat	aatgacaatg
141361	agcagggtgt	gccccagcct	gtcttcaaac	tcagcctgag	gattataaac	ccagaaYacc
141421	atggctRaca	ccacaaactt	aggcagatga	cagtcccaag	gtaataaaaa	cagccacaaa
141481	atgcttccaa	gacaagtatg	aagttcaagt	tctctgcaag	aaaggtgatg	aatgaaatga
141541	gcaacattat	taacaatact	tccaaaagca	gataacgtaa	aaacaaaatc	ttaaaaaaat
141601	gactaataat	tctcggattt	aaaaaattat	gcaagaactc	acattaaaag	atcatacaga
141661	gtgttatgta	agacagacaa	aagaaaaata	tgtacttaaa	acacaatgta	gaataattta
141721	agaaaatgca	aatcaaagag	actatttaag	atttcaaaat	gaaaagagag	tttgcctaga
141781	attgagtatc	acttttttta	gcgaacattt	caccttctat	tttttatctt	tttcaggtta
141841	acaacttttt	aaaaaattaa	aatccaatat	ttagactaaa	gttattatta	atttagttgc
141901	atcctcagat	ttattgggaa	ccttggagta	tcttttattt	tttctaagtt	tttaaaagta
141961	atgtacaaca	tccatatata	ggattgttca	atgaacaatt	atacaaatga	acaatgtata
142021	tatggatgct	atacattaat	ttaatgaaca	atatgttcat	aaatgttgag	ctcaatatat
142081	ttttacaaag	aaaacaacct	tgaaacaatc	accaagttca	agaaagaatg	tatgtagagc
142141	agtcctcctg	cccccaatcc	ttcccccaag	gaaccacaat	tctaagttct	aagcataatc
142201	aggttttgcc	tttaggtcta	tttttgaaYt	ttacaaatac	tttcatattt	gtctttcctt
142261	ttgcttaaca	ttatgtttgt	gactgttgtt	tttattattc	cttccttatt	gtgctgggta
142321	gtgttctatc	agttgaaatg	tcccatagtc	acattgttcc	gttctgtggt	tgatgttctt
142381	tgtgcaagtt	tccagctcag	agctattgta	agtaattctg	acacattcat	gtttgtgtct
142441	tttgttgcac	atctgtactc	atttctgtag	attgtaaata	agtagtgatt	gtcattgtac
142501	agagttcYgc	atcatctgtc	ttttaacgta	accattatcg	agtatgtgga	gtgttattgt
142561	aatattaaat	tatggttcta	atttgcatta	ttctattaac	taaacagatt	gagcccattt
142621	tcataagttt	gtttaccatt	gggtatcatc	ttttctaggt	tgcttgttca	ggtctcttgc
142681	ccatttcccc	ccatagtctg	tctgtatttt	tctaatgcaa	gcatcatatt	gatatcagac
142741	tttcaacagc	cacatttaac	aaagagaaaa	atggaataat	agtttcacag	tgcaaaggaa
142801	aataattcaa	acctagaata	ctttttaaaa	aaaatttagc	tgagctttta	tttaaatgca
142861	aatgtgaggt	aagacaattt	ttagatattc	tacaactcta	aatgtttatc	actcaaagac
142921	tcatttggaa	aggactttgg	agaaatgttt	aaatgtttct	ccttgattcg	tagagaatca
142981	aatcaaggag	aaagcaatga	gatattgcca	actaggcaag	tacaaatttt	caagtttatt
143041	atcaattaag	taaataagga	atatgaagaa	aaatgtagat	tctgtaaata	agaaagcaaa
143101	gcattaagca	tactcacttg	actggcaagg	gttgggggtg	ggggtggagt	cctagtctta
143161	acaaaatata	cacataatat	ttgtggagaa	aagttttaaa	ctctactgaa	ggatattaaa
143221	ttatagctaa	aacaaatgaa	gaagcagaac	atgtttgaag	atgggaagac	aacattttaa
143281	aaatgttaat	tttcctcaaa	attaatgtac	atatttaata	ttactcccat	cggtatccca
143341	gtctgagttt	tggtagaatt	agaccaacta	tttaaaattt	gcgtagacac	aaaaatgccc
143401	acaaaatatt	cttaatagga	agatctttgt	agggatctca	gtccatcatg	tattaagaca
143461	tatttcaaac	ccataatatt	aaagtaattt	agtgctggga	agtgatcagt	tagagcaatg
143521	gatcagaaac	agatccaccc	atttggaaac	ccaatatgtg	acagtagaga	tgctacaaat
143581	cagagggaaa	tatccggttt	ttagtaaact	gtgttagaga	attatttcac	catatgtaca
143641	aaaatggctc	atgggcagag	aatggggttt	aagggattgg	tgagtaaaac	gtgacaaata
143701	ggccacatgg	aattataagg	ggccttaatg	accatgggga	agactttgga	atctgtttta
143761	tttacttatt	tatgtttgag	acagggtctc	actctgtcac	ccaagctaga	gtacagtgtt
143821	gccatgatag	ctcactgcaa	ccttgaactc	ccgttgctca	agtgatcctc	ccgccttagc
143881	ctcccaagta	gtagctggga	ctacagacac	atgccaccat	acccacctaa	ctttaaaatc
143941	tttcttttac	tttctttctc	tttctttctt	tctttctttc	tttttctttt	cttttctttc
144001	tttctttctt	tctttctttc	tttctttctt	tctttctttc	tttccttctt	tctttctttt
144061	cttctctctt	ccttccttcc	tttcctttct	ttttctttct	ttctttctct	tttttttttt
144121	tttgagacag	ggtctcactc	ttttgctcag	gttggagtgc	agtggcatga	tcttggctca
144181	ctgcaacctc	tgtctcctgg	gcttaagtga	tcctccctcc	tcagccccca	agtagctggg
144241	actacaggtg	cgcaccacta	tgactggcta	atttttgcat	ttttttgtag	agactttctc
144301	actatgtcac	ccaggctaga	cttgaactcc	tgggcttcag	cattcctccc	actttggctt
144361	cccaaaatgt	tgggattaca	ggcatgagcc	actgtgccca	gcctggaatc	tgttttaaat
144421	aaaatagaag	tcataggaga	actttatgta	gaggattaca	tgatttgatt	tacatctcca
144481	aaagatcacc	agtttttgag	cagagaatgc	attctagggg	caagaatgga	atcagagact
144541	gaaacagatg	atattaaggc	aggcaaatcg	ttagagtcag	acttgaccac	agtaacactt
144601	aatgtaagaa	gagagtggag	caatggtaaa	caaaagatct	gaagaaaagg	aaacgtgaag
144661	taagaaagta	aagaatgtta	tacccaggga	agttgtccaa	gtataggggc	aagagctaca
144721	catcttcaag	aaggtgagga	tttaaggagc	acctctcccc	taaggtcttc	ttcaacaacc
144781	tgtggaagag	gaaatctagc	cgagagaggt	gctaaacaga	aagttaggaa	aaaggagaaa
144841	ttgtggtaaa	aacacataaa	caaaaacaaa	accaaaaacc	aaaataaccc	gaggtattag
144901	cacgatgttc	ataaatacag	aatgacatct	gggctactat	gagaataata	gacaaagacc
144961	agaatgtgaa	tgttacaata	gtatgtcact	gaggaggaaa	aggagagagg	aggagaataa
145021	tggtgcgaat	ttctgcattt	ttaaagtagg	aaattggacc	gggcatggtg	gctcatgcct
145081	gtaatcccag	cactttggga	ggccgaggtg	ggcggatcaa	gaggtcaaga	gattgagaac
145141	atcctggcca	acatggtgaa	actccgtccc	tactaaaaac	acaaaaaaat	tagcggggcg
145201	tgatgacgtg	aacctgtagt	cccagcgtct	ggggaggctg	aggcaggaga	atcacttgaa
145261	ctcaggaggc	ggaggttgca	gtgagccaag	atcgtgtcac	tgcactccag	cctggcaaca
145321	cagctagact	ccatctcaaa	aaaacaaaaa	caaaaacaaa	aaaagtagga	aataaaaaaa
145381	tgtggctgga	cacagtggct	catgcctgta	atcccagcac	tttggaaRgc	caagacaggc
145441	ggatcaactg	aggtcaggag	ttcaagacca	gactggccaa	cctggtgaaa	ccccatctcc
145501	actaaaaata	caaaaattag	ccgggcgtgg	tggcacatgt	ctgtaatccc	agctacttgg
145561	gaggctgagg	caggagaatc	acttgaaccc	gggaggcgga	ggttgcagtg	agccaagatc
145621	tccccattgc	actccagcct	gggcaacaaa	atggaaactc	agtctcaaaa	aaaaaaaaaa
145681	agaaaagaaa	aaaaagaaaa	aatgggaccc	taacttttaa	atcctttttt	aaaagtatca
145741	ttttatttca	atattacttt	atgtgaaaca	tttaaggact	aatttctctg	ttgctgaagg
145801	aatatctgaa	attcaccaaa	ttcattcttt	cagttttatt	ttatttcatt	ttcccctact
145861	gaattttaat	taaccttaat	agttgtatat	ataattaccc	cttttctttt	agcatgtata
145921	tgaatgtgtg	tatatgtata	cacacagaca	gatatatgtg	tatatctttc	tatgtgttga
145981	tcatccatct	atttctacat	atgcatgtct	agaatggcat	gaagaaggtc	agttctgggt
146041	agtagactga	ggattttctt	ttcctcactc	ttctttctta	tctataagtt	ttaaataaca
146101	atcatgctcc	acatctacaa	aaacaagtga	tgtcattatt	ctaaagacta	gagtgaaaat
146161	aggtgcagag	ggaggaggta	agcaaaatgt	attttgcata	attttctaag	aaaaatgaga
146221	tattacatgt	cagtttttag	aacagtgtct	ttcacttagt	aggtgctcag	tgaaagatgg
146281	caatgatgat	caggattatt	atttcccaga	cttccaggga	gtctctcctg	cctccttcaa
146341	tttctctgcc	attgactcta	aaaaactcct	tggacaaaat	gcttttgtcc	atttaccaat
146401	agctctgtgt	tgctcaggaa	tggaggggaa	ggaacagaaa	tgagcagaca	tctttgttct
146461	atcaattttt	gggagaccag	ggaaacaaaa	taaaacaaaa	gacaagaagt	gcttcatttc
146521	taagcatcac	aatggctgaa	attatgcaac	ttgcatgtag	tctttagaga	ttccagttaa
146581	gccttcaaaa	ctaattatcc	agcttgttgt	ggtggtggtt	gtttgtttgt	ttttgcaatc
146641	cctgtattag	tctgctcggg	ctgccataac	aaaacgcctt	agcctgggtg	gcttaaacaa
146701	caggaacttc	ttttcttaca	gttctggggg	ctggccgaga	tcagggtgcc	agcttggttg
146761	atttctggcg	agggctctct	tcctggctgg	tgactgctgc	tttctcattg	tgtcctcatg
146821	tgacctttct	gtgatgcacg	ctcaggattg	aggaagagct	ctggtctgcc	ccctttttct
146881	taaaagaaca	ctaatcctgt	gggatcaggg	ccctaccctg	atgacctcat	ttgactttat
146941	ttacttcttt	aagggctcta	tacactcata	ttggggatta	gggctttttg	acattaattt
147001	tggagggacg	taatttagtc	catagcagct	tctcaatgtt	tttacaatgt	atttgtttgt
147061	tttgttttaa	aactaaaatc	catagatggt	ggcatttctt	ttttttaaga	gacagggtct
147121	gctctgtcac	ccaggctgga	gtgcaggggt	gtgattatat	ctcagtgcag	cctcaactcc
147181	tgggctcaag	ggatcttcct	acatcagcct	tcagggtagc	taggactaca	ggtgtgcacc
147241	accatgccag	gctaattttt	aaaatttttt	tgtagagaca	gggtctcact	aaattgccca
147301	gactggtctc	aaactcctgg	gctcaagcaa	tcttcctttg	gtgtgccttg	gcccaccaaa
147361	ctgatgggat	tataggcatg	agatactgca	cctggcccta	taattcttat	ttttattttt
147421	tgagatggag	tttagctctt	gtcacccagg	ctagagtgca	atggcacaat	gtcaactcac
147481	tgcacccttt	gcctcccggg	ttgaagtgag	tctcttatct	cagcctcctg	agtagctagc
147541	attacaggtg	cacgccatca	tgcccagcta	atttttgcat	ttttagtaga	gacagagttt
147601	caccatgttg	gccaggctgg	tctcgaattc	ctgacctcag	gtaatctgcc	caccttggcc
147661	tccctaagtg	ctgggattac	aggtgtgagc	cactgtgccc	gactggccct	aaaagttttt
147721	aaatgctcta	ttgtcccttg	aacataagag	taagacttga	atctatataa	ttgatagaga
147781	ccttaaaaca	tttctacctt	tcttatccaa	ttttttccct	ctccatctat	accatcctac
147841	agagacggat	tcctatacta	aagaagggga	ttccagccac	tcacttctgg	gcggccagta
147901	ttggcattta	agccactaaa	atattttttg	atatctaatt	gaatttgtct	aatttgaatt
147961	acagatacca	ataacaaaat	cattagttta	ttcttttagt	atctcaccat	atgcaaagca
148021	tttttgtgtg	catttggttt	gtttgtttta	tcatttcaac	catcttaaga	agtagagaga
148081	gaagatctag	tcctaatttt	atacaggagc	aagtagtcaa	gtgatttacc	agcaacaata
148141	acaaaaaaca	acaagcaagg	gacagagcca	gcaagaaagt	tcattttaaa	gaacaattgg
148201	catagccggg	tgcggtggct	cacacctgta	attccagtac	tttgggaggc	tgaggggggc
148261	agatcaactg	agatcaggag	tttgagacca	gtgtggccaa	catggtgaaa	ccccatctct
148321	actaaaaata	caaaaattag	ctgggcgtgg	tgggggatgc	ctgcagtccc	agctacttgg
148381	gaggctgaag	cagcagaatt	gcttgaaccc	cggggagatg	gaggctgcag	tgagccaaga
148441	tcgtgccatt	gaactccagc	ctgggtgaca	gagcaactct	ctgtctcaaa	aaaacaactg
148501	gctgtttttt	tcccctctct	tttctgtttt	tactgtgcac	tgtttcaaca	gttaaataac
148561	tttaaaaata	attaattcta	taagaaagca	tgagaagggt	actgtaagag	aataaaaaga
148621	caaatgagac	atgttttttc	tcccctaagg	agcttccatc	agggtgcaca	gtgtttcatg
148681	caatccaaac	agagcattgc	tgcatgaaga	gggttatgtc	tttccattcc	tctttaaatc
148741	aactttatct	gtgagaatct	cataattttg	aattatggtt	tagtgttcat	ttatggttag
148801	gattatgatt	aaagtgcaat	taatctctga	taaagccatg	tctacattga	ttcactaaat
148861	cagaattttt	gagggtatat	tttgctttca	tgattccttt	aataaccaac	ttctggctaa
148921	tcagacaagt	actgcaataa	atccatgtgc	gtcattgatg	ataatatttg	gattgacttt
148981	tctttataat	attttgagtc	atggcataat	atcgatattt	atacctctKc	cagtcctaat
149041	gcataccact	ttgattaata	aaatactttt	aaaaatactt	aaaatatagg	taataacaaa
149101	ccaacaatca	atctttctat	agcttataca	atgccttatc	cttctgattt	ccaatgatta
149161	atcactttct	tttctcttat	ttaaattatt	ttcaaaatat	tactgaaaca	tcctttaaag
149221	agtttttctt	tcagggaaac	tcataaaaat	ctatctatgt	tcactgaaac	aagcttactt
149281	tcagtataag	accttacttt	tttgggggca	aattattcaa	tcattgatac	ttctctttat
149341	gaaatctcct	aaattgcaga	tgatttggct	tcagtgtatc	tttaatgata	gaaatcacgt
149401	ataaattggg	tttaaaattc	caaaggataa	ttttgaggac	tgcagtacat	ttggccatta
149461	gagagtctag	aaatgccaaa	ttgaccaggt	cagaatgaat	ggtcttgggc	tgccatgttt
149521	catggcaacc	tgtatgcaga	aacttaccat	cttcaaatgg	gcttgttcag	atgctgggaa
149581	ctgctttagg	ccattccaaa	tcaataagac	agccaattat	acttgagtta	agtaaaataa
149641	taagcaagaa	ttgcaagaag	ccctgtccaa	gcacagtttg	aaaaacttcc	atacagagtt
149701	cttaaaagca	gactgtaact	tctaatgaat	tacttgcttc	attattactg	ctgcttgaat
149761	caagtcaagc	agtttagcca	ggacttcaca	acatgtctct	gtcactgcgt	tgatacatag
149821	taagttgtga	atggcctgcg	atgtttcttg	caatgatttt	catcatgccc	agccagtcct
149881	gccaatctgc	aaatgttcag	gcccccacat	atggaccaca	cagcccatgc	aacgcagtca
149941	aaatctgtta	gtcacgggat	gatccgtctg	gtattttcag	ctaacttaac	aattaattgg
150001	gtagcatctg	aatcaataat	tcaatgatcc	agtttggtca	gcaatgtgtc	caggctttcc
150061	tgatgattgg	tcgacttgtt	ttgattttca	ggacccagtc	acagaagtag	tgaagtttta
150121	actaggcttt	caaaaatatt	catacaactc	agctatatgg	aaataattca	tagaagcata
150181	actctgccaa	tgataagagt	gagaagccat	taactcaacR	aatgagtgac	ttgttattca
150241	catgtcttac	taaattggca	actatggctt	tctcattttt	atgttattct	atgtatatac
150301	atgtatcgaa	atagtgttat	ttagagatct	taaacatgtg	gacaaatatt	ttgatagagt
150361	ttggggaaaa	cagcctatat	ccttgcttta	tagaaaaaga	gttttcatga	gaaagaagtt
150421	atatttattc	agatatatat	gtatgagtac	atatctagat	ctatataggt	ttatatacat
150481	atataataat	atacttgagc	cccactcttt	cattccacta	ccacttcgta	gccaaaagac
150541	agagatctcg	atataataaa	ttaaatatta	agatatatat	taaagtatac	atataatgta
150601	attagataat	aaagataaaa	ttatttgaaa	tgcctcaaaa	ataatacaga	ttttaaaaga
150661	aaatgagagc	ataaaaacct	ttaaaatgta	tggatcaaca	aagaaataca	ttgcaaaatt
150721	attacttaat	tagaaaatcc	cttttaaatg	ctctttgatt	ccatgagact	tttcagctga
150781	caaagggctt	agccacctct	taaagcagag	gctctctcca	atacccgaag	ataaatatct
150841	accaggagct	ttttaaacaa	tgcttgtcat	gtttgtcatt	atgaagcaga	ctcatacata
150901	aattaagttt	tcctaaactg	tagctatgaa	ttaagagtcc	cacgatttgt	gctattgcta
150961	acctactccg	gtggtatgtt	gccatcactt	caattgtttt	aatgataaat	ttcctttaga
151021	aaatggaagg	atctgttgac	agacaaaaac	aggaactaac	aatggactat	ttagacttgc
151081	aaatgatgga	acatttaatt	attccaaaat	agcattcccc	agttagggta	tgatcattaa
151141	atccatcatc	cttcagttta	tatgcatgca	acatttacca	tgtctacctc	aaacaggagt
151201	cagtcatcca	aatatagatt	tttggaccat	ccatttcagc	atgacatttc	atcgaaagcc
151261	tggaatttca	tttattttct	gtaacagaga	taaagtgttt	gtaaacgatg	tgataagacc
151321	ataaagagaa	agtaaagtga	aattcagctt	catacagaga	taaatacaga	ccctactgaa
151381	catagcagta	gtagagaaag	agaaaaatga	gagacaatac	gtcagcagca	acattccagg
151441	caagaatcga	tgttccctac	atatggtttt	taaaaatgtt	tgctcagttt	tagttctctg
151501	aatttgcttg	caaaataatt	tgcatttaga	ctcaagacag	tggcggcaag	atcaagacaa
151561	tctaaaacta	aatatacttg	aactcttttt	gtcaatttcc	acatactgaa	aaaaaatgtt
151621	tatgtctcat	tggagagata	aatgtctcag	aaaacagtgt	tttataaaat	tcagaagtta
151681	attatttttc	tgcaggtcct	cgtttttcag	gaagaatata	gagtagctag	gtattcatta
151741	tttgaagtct	aactggagac	aagttatgtt	taggacctgg	acaaacattt	catgagatgg
151801	cagstacaaa	taaaaaccaa	ttaattctcc	tccagcgatg	tttctttcct	ctaatggaag
151861	gcttgtggtg	tgcaagaggt	gtttgggaag	gatttacaag	caagttttcc	atgaaaggac
151921	attactaaca	ttattaacgg	cccctctcag	cccgggtcct	tctcttcacc	atcattttgt
151981	agcccaggat	gacaaggcct	agagaagtta	agtgactgac	ccaaggccac	atgctgatgt
152041	caaaatcagg	cctcgagctt	atgtttcctg	acacttactc	aaatgtaatt	ttatgccacc
152101	attctgccag	tgggaaatgt	gtgtgtctgg	ccatgtgtgc	atacactcta	ccaaaatgat
152161	gtccatgaaa	ttttaaatcg	caccatgaaa	atgagaagta	agcatctaat	atcctatctt
152221	aatcaattgg	accaaattta	gaaaaaattt	gaaccctggc	cgaacgccgt	ggttcatacc
152281	tgtaattcca	gcactttggg	aggtggagct	gggcggacca	cttgaggtca	agagttcaag
152341	accagcctgg	ccaacatagc	gaaaccccat	ctctactaaa	aatagaaaaa	ttagctgggt
152401	atggtagtgt	gcacctgtaa	tcccagctac	ctgggaggct	gaggcacaag	aatcacttga
152461	acccaggagg	cagaggttgc	aagtgagcca	agattgcacc	actgcattcc	agcctgggtg
152521	acagagccag	acaccatctc	aaaaaaaaaa	aaaaaaaaaa	aaaaaaggaa	aacaaggaaa
152581	gaaaagaaaa	aaaaatccca	agctgttatg	aaaaatagtt	ttagacactc	tatgaaaggt
152641	acagaattcc	tcttttcttt	gaaatacttg	tgaatagggg	tgtgtgtgtg	tttgcgcatg
152701	cacgtacatg	tgtatacata	catatacaca	tgctatatgt	accatatata	tattgaaaga
152761	gagaatgatc	aggagactcc	tatttaaagt	atgcttaaaa	acttcagtca	cctataacca
152821	tcctaccctc	aggcctggcc	ttttgaaacc	agaaagactt	tttccttttc	cccaattttc
152881	tgtcctattc	agtcccccga	cctctgagcc	ttgtcagtga	tggtggatga	caagaaagaa
152941	atatgttaga	tgccaggtgg	tggagtaggc	attcactctg	tttgactttt	ttctattgga
153001	tctacaacat	agaaatagac	aaatcacaca	cctacggagt	tgtctttagg	atttgattag
153061	ctgacatgtg	accctgctaa	gagccagcaa	actctcctca	tcctatctgc	cctcttcatc
153121	ctggcagaag	aaccctggtt	cattatttct	gagaaaaaca	atcacaagta	gctccgtggt
153181	tgtcctggtg	aagatagaga	aatgggagag	gtatcttttt	ccttacaaag	gaaattgata
153241	ttattacaga	tagatgatat	aaacttttaa	atgccatggt	gatatagctg	cctgattcct
153301	aaataaagaa	tataaataaa	taacaggagt	atagttggtg	gcataagcaa	aactcaccca
153361	ttttccctta	aatgggctgg	caaaccaggg	ctgagaggag	acagtcgggg	agatttaaac
153421	taggaaatca	gagaaatgct	gcaggaagac	acaactcact	ccataatgca	tcctatttac
153481	gaggcaaata	aatatcaatt	gtgtacaata	ttgccatgtc	tacaaaagca	aaactcccat
153541	cattttgaca	ggtgttttgc	atacatatga	actgcaagat	caagcttgat	atgtgtgatt
153601	tcttacaata	atcagtatct	gaatcttctg	gagttggcat	gcagcactct	gtgaaagatg
153661	tcacatttag	actctgcctt	acataaaatg	tgtgcaatgt	ctatgcttaa	ctcccggcac
153721	ctgtctctgc	cttattttct	ctgcccactt	aaaatatctt	ataacaatgt	ccccatgttt
153781	accatttttt	ttcatacgca	gagttttgaa	cgtggtacgt	ttgaaagttt	tgtaggaaaa
153841	atcttttgca	tggtgaaagc	agtttatagc	aaacctacat	atctacagaa	acacttgtat
153901	ggaaaaaaga	aaaaaagaag	agtgctgcca	gacatttcac	agaattcagt	gctgcaatgt
153961	acccaacatg	gatgaaatct	ggtcccagca	aaacaggatt	tctttctgtg	agaaaatccc
154021	gcggcatata	gttccccagc	ttcctttata	atgtatcttc	cttcattccc	caatctcctc
154081	cccttcaatg	gattcaactt	tcaattttct	accatttccc	tgcaaaatgt	ctagaatcta
154141	ttctttggct	tctcataatt	cctgtcctga	ttccatttcc	acaccatttt	ctccaacctc
154201	atgtctcttc	cctttttttt	tttttttttt	tttttttttg	gcaaaaggtc	accgtgaagg
154261	caaaataggt	tagcgagaag	gcagcttcta	ttgggctatg	cttcaatttt	tctcttttga
154321	gtttctccct	acctccttgg	ccatttcctt	aaacctgtct	acacagctgt	acaccactga
154381	aagtggggtg	ttgatatgcc	aaagaaaaat	gggcaaactc	cgtgtgccag	cacaccatca
154441	catgaacaga	aaatgagaaa	ctgaaaatac	atttggtgaa	ggaattcagg	aaactgaggg
154501	acaaattgtc	acaatgaaga	tttaccccct	tggtgtcaac	acacccagga	agatcaaagt
154561	gaaagacgag	gtagaagcta	atgtcagccc	acagaagctg	gatgtgagca	cagaggcagg
154621	caggccaatc	atgggtagaa	ggatagagct	ctctagggga	gctaagttca	gagcccagag
154681	atggcgaaac	ctgagagtgt	tttagaacca	gaaaggcact	gtgacatccc	tgaggtaatt
154741	taggRtgctg	taagtagaag	cggaaaggaa	taattagagg	aactacattc	tattcaggtt
154801	tgtaggaaga	ataggatgga	gagagtcaga	gacttatgaa	ggccctcatc	ttcatcactt
154861	ctagggggct	gatggcttca	aagggatgga	atccaacatc	tgacaaatcc	gggtgtttat
154921	cttgctccta	ggaagtaagg	atggttcttt	attccttcaa	acttaaggat	attacttttt
154981	ctctccttaa	aatcaaggaa	attaattcta	cataaaaata	attatatata	atatgtgtat
155041	aaataacata	catattcata	tagattatat	atatgtatac	atatatgtat	gaatttgaga
155101	aataaataaa	ggaaaatgaa	ttaattcaaa	agcaaagact	gactgtccag	acaaaataag
155161	ctggaagatc	attaagcaat	ttactccaga	gagtgttcag	atattaccat	taacacagaa
155221	atataggaca	ctgacattct	tcataacaga	tgctcttgaa	aaatgaaggg	tttgaaaaaa
155281	agaataagga	aaaatagcta	atatatgata	aacagctcat	agaatcagaa	agaaatacaa
155341	ataaaaaaac	tgtcctttaa	aaaatatgga	aaatttataa	acttgatttt	cttcaaaaat
155401	cattagtttc	agagtactac	aaaaatattt	ttagtctaca	ctgtatgaaa	gacatatatt
155461	ttcagataat	aacacatgga	ggcaaattag	ctttgtgttt	gcatcttgca	gacattgcag
155521	taaacattta	gccaccaata	tcaataataa	gtttgtttta	ttcagtataa	tagtcttcaa
155581	aacatagacc	tgtgtttaca	gatcaagatt	aaatcaaggg	gttattatta	accctggtag
155641	tgacctctct	ttgctgaaaa	tcaaataaat	ctaacaggca	tttcttttaa	ctaagccctt
155701	gaaagagaga	ggttctatca	gtgtttgcaa	agactgttaa	actagaacaa	gaattagcta
155761	tttgtttctg	gtttactttg	ctttaatatt	ttaatggtgc	tataaatttt	ggagctaatt
155821	aacataagaa	aaagttccat	ccagtgtttt	aaaatatttt	agaacattct	ataaatagtt
155881	tcagacaatc	ttctgactca	tgtttaaaaa	catgtccaat	ttatatcaga	ataactcaaa
155941	attgcaaRta	acaccacctt	ccacccagaa	tcacttctgc	ttaagacaca	gtaaaagtaa
156001	ccagatttac	tcccctgcct	gaaacaacct	gttataatct	gtttagtctg	ctataacaaa
156061	atagcttaga	ctgggtaatt	tacaaacaat	agacatgtat	tgctgatagt	tctggaggct
156121	gggaagtcca	agatcaaggc	attgacagat	ttagtgtctg	gactgggaca	gttcctggta
156181	gatggtatct	tctatgtatc	tttaaatggc	agagggagtc	aaaaagctcc	cccgggcctc
156241	ttttataagg	acactaattc	cattcattag	agctctgccc	tcatgaccta	atcacccccc
156301	aaagcacctc	actgcttaat	attatcacac	tggggatgag	ttttcaacat	atgcattttg
156361	ggggttgggc	acaaacattc	aggacacagt	gcaaacaaaa	acaaaaacag	atggacaaaa
156421	catatgaaac	aacaattttc	aagacccact	ggacatatga	caacaatgat	ccctgagaga
156481	cggtagacaa	atgaggtagg	ccctgtgatt	gtcccagcta	ctactctagc	ttacttacaa
156541	gccatgttga	gggaggggag	agagatggag	ctgagagtcc	ggggagacca	aggaggagag
156601	agagagagag	agagagagag	aaagagagaa	caaactctgg	gagttctgca	gagggtcccc
156661	cttcagtatt	tatctgagta	cagaccaaac	tgtgcacgtg	gggaaactac	ctaaagccag
156721	aggggaaaaa	ctacctaaaa	ggatgaggag	ataatgcaat	gtaataatga	aaaatattta
156781	gttgatcaaa	cacaaggcaa	gaacacaggg	aaaagggagc	aaagaatata	caggacaaat
156841	agaaaacaag	tagaaagata	atagattcac	atttatccac	actgataatt	atattaaatg
156901	taaatggtta	aaatgcataa	gtcatcagct	tggaccagaa	aagaaaacaa	gcctcaacta
156961	cagttgccta	caagaaacag	actttaaata	taaaggcaaa	aatagtttaa	aagtaaaaga
157021	acttttactt	tcaaagttct	tttaaaactt	ttaaaaatat	accaaaatat	accatgctaa
157081	aactaatttt	taaaaagtgg	aagtgactat	atcagtatta	gacaaagcag	atttcaaggc
157141	taagactatt	aagggatata	aaagagtgca	cacagaatat	ttaYcaagat	aaaccgtatt
157201	ctgtctcata	aaaggtctca	ataccgttaa	aaggattcaa	gttatataat	gtatactctc
157261	tgaccacagt	gaaattaaat	tagaaaccca	taacaaaaag	atgtttgaaa	aatagtcaag
157321	tcattggaaa	ttaaatatac	ctgtatctat	taaataatta	tttgttgttg	aaaaccttcc
157381	cacaaagaaa	gttctgggct	cagatggttt	tgtttgtcaa	ttctaccaag	tatttaataa
157441	aaaataccaa	tcctacacaa	aatcttttac	aaaaagagag	aatatttccc	aagtaatttt
157501	ttgaggtcag	tattactctg	ataccaaaag	caagcattac	aagaaaaggt	aagtatagta
157561	tgatatccct	aaagaacata	catgcaaaat	tgtgcagaat	tttagcaaat	acaacaaata
157621	cataaaagca	taataaatgc	agaattttag	caaatacagt	aaatacataa	aagcataata
157681	tgttttgaac	aggatagttt	gtcccgggaa	tgctaagtgg	atttcacatt	caaaagtcaa
157741	ttaatgtgat	tcatcacatt	aatgagctaa	aaaagataaa	atcatctcag	tggacataga
157801	aaaagcactt	gacaaaaatc	caacatccat	tcttgttttt	ccaaaaaaaa	aaaatttcag
157861	cgaactcaaa	attgaagaga	tttttctcaa	cctgatagag	ggcatttatg	agaaatctat
157921	agctaatatc	ttcttttaat	aaatgtttcg	aaaattaatg	agatcagtgc	aagcaatggt
157981	gccctgggtc	tttgagaaag	tagagctcac	gtcagctgcc	tgatttggtt	ttgtgcctac
158041	taaatttttt	agatcctagg	ctagggtttt	gtgaaatgct	ttatctagtg	taactggcgc
158101	ttcctgctgc	cagtctacat	tcattcgtct	ttagcctgca	ccacccttaa	ctagggaggc
158161	cgatggctgt	ctctcctcag	gttaactgtc	tggggatttg	gcctcagaga	caacacagac
158221	gtaaagctcc	ttgggattcc	ttccatcatt	tgtgttctaa	atgattagta	agagtgcagt
158281	ctaattttta	ttgtcatgca	tgacttgggg	tacagtcatg	ctgaaccaca	taaatcttta
158341	gagccaatca	ttgcaggaac	tggtttgact	gtttccacaa	gtaaWctcgc	cagcattctc
158401	aatgtgggct	cttgaatcat	cactcctaaa	tttctgagct	catctgagct	ttgcgataat
158461	aatagtcata	attctgaatt	taatatagat	gctttcatct	gcaaagtgct	tggcaaacat
158521	taactaatta	gaccccggat	gctcctcttg	aggtcctcaa	acaaatagca	ctgcctcatt
158581	tttgaaatga	ggggtaagaa	aaagacctga	agctcagagc	tcattagggt	agcacaaaag
158641	acagtgggaa	tcaaacctag	aacctgctct	cgtcacatgg	gcttgggtga	catacctcca
158701	acagaacact	ttcctggaat	cattaaccta	acttttcttt	tgcaaggaac	gtgcatgaca
158761	aatgtggtta	ctttaaaatg	ataggatttc	tttttatgag	ttattgaagt	tttgcactga
158821	atattccttt	ctacctaaag	aattaagccc	cacatcttga	gtcatgcttg	gaatggtatt
158881	aacctcatat	tttaaagagg	cttctcctag	ggcttatggt	gaaacaagaa	tacctatgca
158941	caggccacag	ttatgtcagt	gagcataaaa	attaagagtg	cctgcaagtg	cctagctgca
159001	ggtcttcctc	atcccagcaa	tcaggtcatc	tgcacaatga	gatacggagg	ctatctgagt
159061	gtctgactaa	actctgccaa	agctccttta	tttgttaagc	ctaaatttaa	tattcccctg
159121	cctccaaatt	aattcaccct	aataatttgg	aatgtccttc	acttttgctg	cctcctttat
159181	gaatcaatct	agagatcaca	agtgaaaagc	taacattact	attgcctctg	tgtaaaagtc
159241	cataaataat	acttcttcat	tatcaacaaa	gagtatttgc	tatccagttc	agtcatgagg
159301	tttttataat	taggaaggga	atctggtaat	ctcttgtatt	tatttgctta	cttttatgaa
159361	tgtagcaaca	attgtgtgcc	aggctattga	gaataaagtg	tgtgggacag	agacatccac
159421	cgattcatgt	gaacaccaac	aagcgtttgt	ctgaatctgg	ccttgaatgt	acttggtggt
159481	ttccttccct	gccagcagta	aatttcaatg	cttgtaacaa	atgatcttta	atggcttcat
159541	tgcaataaag	gcagcccatt	ttgttctgtg	cagccagacc	caSgtcttgc	ttaaagtagg
159601	ccaccttccc	ttggagcatt	tatcccacta	tttcaaagtg	cttggtatat	attatagaac
159661	tttctccatg	gttttagaag	acatctgaac	aatggttaag	aacaaagttt	ttagatggga
159721	gaactgactc	agcagatctc	ctcccaaggt	cagcctcatt	agcagccaat	cagatgtgtg
159781	cctgctgctt	gttcctttgc	atattcaaca	catatttatc	atgtatttat	tatgtggtac
159841	agtacaggca	tacttcctgc	cctccgagag	tttacagcct	ggtaagaata	tgagatagtc
159901	aagtaataat	gtataaaacc	ctattagaat	aaaatatgct	gcttcgacac	ttaggagagt
159961	gactccattc	cagtttgggg	catgagggat	gatatgggac	agtaactgct	ttctacactg
160021	agatctgaaa	ggcagtatgt	gttagtaagc	tagagggaga	ggcagaaaag	agagctgcag
160081	gccaacgaag	tagcttgcat	gaaagcctgg	aagcaacaga	gtgtgcagag	tgatggggtg
160141	agtggatttc	actctatcag	gaccaaggta	ggaaaagaga	aggcaggaga	tgcagctata
160201	tatatacttg	aaccaggttt	tgctggtttt	gtaagccatg	gtaaggactt	tggacttttt
160261	cctgagagta	atggggaaaa	ctttgaaggg	cttgagcaat	agcatatcag	gactggtttt
160321	gtatctttta	aaatatcagc	caggtgcagt	ggctcacacc	tgtaatctca	ccacttggaa
160381	ggttgaggca	ggaggatcgc	ttagggccag	gagttcaaaa	tcagctgggc	aacacaacaa
160441	gacctcatcc	ctacaaaaat	aaaaaagaac	ttagctgtga	gtggtggtgc	acacctgggg
160501	tcccagctat	tggggaggct	gaggtgggag	gattgcttga	gcccaggaag	tcgaagctgc
160561	agtgagccat	gatcacacca	ctgcactcta	gcctgggtga	cagagtgaga	ccctctctca
160621	aaaaaaatct	ttttaaatca	tttgtagagc	agagtggaga	aagattgttg	ggcagaggcc
160681	attcaagagg	ctgctgtagt	aacgcagata	tgtcatgatg	gtggcctaga	ccagaaaagt
160741	agcaatgaaa	acggagaaaa	tggaatggac	ttagagaaga	tacaagagtt	aaaattaaga
160801	ctttcagatt	gttgactatg	gcaggtgaag	gagagggcgg	agtcaaagcc	gactcccagg
160861	tttcagctgg	gttgatgttg	gttctatttc	ttgatattag	gagcacaagg	aagaatagat
160921	gagagtagga	aatgaggatg	agaaatgaaa	atttcatttg	gtagtttaat	tctaaactgc
160981	ctatggggat	ggcctgtaga	cagctggatg	catttgtgtg	aagtctagga	gagagagaga
161041	gactggggat	atgggtatgg	gcatcattac	tataaagata	gtagatgaac	caggaaattg
161101	ccccagggag	gaaaagaggg	gatccttgga	taaaatcact	gaagaatatt	gtcatataag
161161	gggcgaagag	gagtatgcaa	ggaagactaa	ggaatggccc	gagaagtaca	aagaaagcca
161221	agagagaaag	ataccacaaa	agcccaggca	acggtgcttc	aggaaggaca	agaggaagtg
161281	aatcaataag	gaactgaaac	atatgaacag	gatttaggaa	aaaggttgtt	ggtgtctcta
161341	gtgaggacat	ttcattttag	tggaatggtt	ataaaataaa	ccatacgtct	gggagctgaa
161401	gagtgagaaa	atatagacaa	cacgtgtaga	ccttttttga	gaaattggga	agaggaggag
161461	agaaacatgg	tattagctga	aaggtgagga	ggggtggata	gctgacgatt	ttacaatgcg
161521	aaagagccga	aaacatttaa	ctgcttacag	agaaggcaag	gaagagagaa	gagaaagagt
161581	tcaggatgga	gagcgcatca	tttatgaagg	aagcaggact	tgtacctcca	gcacttgtaa
161641	ttttagaggg	tgtccttgac	ctcaggttaa	atattaaaat	gcataccgag	ttcacatcaa
161701	ctacatgttt	tacaacaaaa	aaattaaaag	ggtttttata	attttgtttg	caaaattagt
161761	tggctgtgaa	taactcacaa	tttataattc	aatatgactt	atcagtaatc	aacgcacata
161821	cttgggaatt	tgggaaaact	gagaacatcc	aactaataaa	ttgttttcaa	atgtagtaag
161881	acatttatgg	atactatgtt	tacaatgctg	acataatatt	acattttata	tgtactctat
161941	tattacatgt	gattttcatt	attcacattt	tgaatttaat	attctttttt	ctggatgcaa
162001	aaatgtctac	aggtacttgg	ctcgttcacc	agtcccaggc	agtttactta	tattgttcaa
162061	tggctgaaat	tctaaagaac	agggttcctg	ccatgacagc	agagtgaagg	gaccagtctt
162121	caggaggagg	agactatcct	ccttttgtac	aggagaaaag	cacaaaagaa	caggcacaga
162181	Sgcaagctgg	taaagtgcca	atctcatggt	ctccattttc	tctattgagg	tgccatcacc
162241	tctttgtgtg	tgtctgtagt	gtgtgcgtgt	gtgtgtgtgt	gtggtgtgta	tagtatatgt
162301	agatgtctgt	agtgtgtata	tgtgtgtatg	tttgtagtgt	ctgtatgtgt	gcatcctgta
162361	tgtgtatagt	gtgggtgtag	tatgtgtatg	tagtatgcat	gtgtgcatgt	gtatagtgtg
162421	tatgtgtgta	aatatatata	tatttatata	tggtgtgtat	atagtgtgta	tatatgtggt
162481	gtgtgtgcat	gtgtgtagcg	tgtatatgca	tagtatgtgt	atgtgtggtg	tgtgtgcatg
162541	tgtatagtgt	gtgtgtagtg	tgtgtcgtgt	gtgtatgtgt	agtgtgtgca	gtatgtaggt
162601	gtgtttgtgc	atagtatgta	tatgtgtgtg	tagtgtRcgt	atgtgtctac	gtgtgtgtgt
162661	gtagtgtgtg	tgtgagtagt	ttatgtgtgt	agcatgtatg	tgcatgtgta	gtgtatgtgt
162721	gtggtgtgta	tatgtgtcta	tgttgtagtg	tgtctatctt	cttgagagat	ggggcattga
162781	tattcctttt	agaaattctt	ctagaagcca	acatcttgaa	aatgagcctg	ctgatggtat
162841	tcagagctgg	ccagctcttc	cccattctcc	ttcaatccgg	gcacgtccca	ccctgtgtgg
162901	ctggatgtga	acacgtacgt	gcaagtgtga	tctctctgtg	tgaacattaa	gaggttgctc
162961	acttgctcca	gttttcacct	ggaagcagca	cttccttccc	cattccctcc	tattcgatgc
163021	aacaggctga	tcagagtatt	tctgttcacc	tttgtggcaa	ctgtgctaca	ctcccctttc
163081	aagccttcct	caaaagaaag	aggagaaaat	attttaatat	gattttaatg	cctagttttt
163141	tctcctttcc	tttttattgt	aaaaatacaa	cacttttcct	gtagagcaat	tagaaaatgc
163201	agatgcaatt	ttaataccaY	cattgMcaca	tcaaccatgt	tactatgttg	ctttttcttt
163261	aaaaaaactc	ttgatagaag	cagtttttta	aacttttatg	tatttaatta	ttttgcaaga
163321	tttcaatttg	cattgaaatt	tattgagatt	tattttatgg	cccagcacat	gacttatttt
163381	ggtgaacata	ttctgtgcac	ttaaaaatgt	gtattctgta	attggtgagt	gagtttctag
163441	gaatgatgga	gttcaagaaa	tgttcatcag	gtcaagttgg	ttggaagtgt	tcgacagaag
163501	tcattttata	acctgctttt	ttattttgag	taaaatattg	tgacagtcaa	taaacatgat
163561	ttttctacaa	aatgctttat	agttatggtg	tattccatgg	tttagctatt	tccctattgc
163621	tggatatttg	ttttaaaatt	tcggtattat	aaagaatact	gtgataaccg	tacatttaaa
163681	tgtgtatgta	ttattgatta	cactacagaa	gataaacttg	tagtagttgc	tatcatttga
163741	atgcatcccc	aaaagttcat	gtgttgggaa	ctcagtcccc	aatgcaacag	tgttgggagg
163801	tgagaccttt	aagaggtgat	tagagaaatg	gattaatgga	ttaatcttgg	gcatgggttc
163861	attttcttaa	gtgagtttgt	tatgaaggca	agtttgggct	gggtgtggtg	gctcacacct
163921	ataatcccag	ctctttggga	ggccaaggtg	agagaatttc	ttgaagccag	aagtttgaga
163981	ccaacctggg	tgacatagca	caatccccct	ctctaaaaaa	aaaaaaaaaa	tcagaaattt
164041	agccaggcat	ggtaacgcac	acttgtagtc	ccagctactt	gggaagctga	ggtgggagga
164101	ctccttgagt	acaggagttc	aaggctgcag	tgagctatga	tcatgccact	gcactcctgc
164161	ctgggcaaca	gagtgagacc	ctgtctcgaa	aataaaaata	aaaaaataaa	aaagcaagtt
164221	cagccccctc	ttgcttttgc	tctcttgcct	ttcctctttc	caccatggga	tgatgcagca
164281	acacatccct	caccagatgc	tggcccctta	atcttggacg	ccccagcctc	cagaatcata
164341	ggaagtaaat	cattgtcctc	tataaattgc	ccagtctgtg	gtatYctgtt	atagcagcgc
164401	aatacagact	aagacagcag	tgtagctgct	agttaagact	tcgtattctt	gaaggccttt
164461	gattcatatt	cattttgagg	ccattttaac	attgtacctt	tacccttctg	aagatctctg
164521	gtgtcttggc	atgtattttc	atcactttct	atatagaaaa	tcagtcacag	gtgactcact
164581	gaatttggag	ccagcatgga	aacaatcaaa	atgccaaaaa	tctaactttg	taaaattaaa
164641	aaaaaaaaat	ctgcctcttt	aaaaatttga	ttcacttctg	ttcttaaaga	tagcaatgcg
164701	agatggtgtt	caactccaaa	actgcaaaac	actgatgcca	agcaatccat	tttaatcatg
164761	gcatgccccg	ggacactttc	agtatttgca	cgaattgaag	gtcatttgtg	gtgagtacaa
164821	ggtcttctct	cctgaatcat	cgtgccattg	tactcacctc	gaaaatgctg	ggatgcctgt
164881	ggggatcctg	aaagcatcag	ctggacatga	tgattaaaat	cttctaatta	tttgaaaagc
164941	catttgggat	aatagagtag	gtttactttc	ctttcattaa	tgtccctgag	caggctatat
165001	aggagttaga	aagtcacaac	ttcactgctt	ttggccaaag	gccattgcgg	tacttgcaga
165061	tgaagaagaa	aaagaaaaaa	aaaaacagag	acaaagtgtt	ctttcagaaa	ggttataagc
165121	ctgtagacag	aacagaatta	aaatacaatt	ctgaatgtac	cagcatacaa	tattttggtg
165181	ttggtttact	gaagagaatg	tcagatcaat	acaccaccaa	gtcaaattga	ctgtgatgtc
165241	taaaataact	ttaggtctgc	ctttagaagg	agctaatggg	aaaagagaga	aataagttac
165301	acgaaggtcc	atgttgggcg	ataaggaact	tgtcgcttag	tgaacaggtc	ttgataatat
165361	actggataaa	tggcactaag	aaatgtctgg	aatcactcag	aatacatgcc	tagaagtcta
165421	gagtaataag	aaacaaacgc	atgtcataat	tcagtgtaag	aaatagcaat	gcaaaggtaa
165481	gatctttgca	ttgtataaat	tcgtataagc	cctgtaaatg	attacaactt	catttcttat
165541	catttgtttt	ggatagcaga	attagagtag	agcagtgtta	gcaggagaga	gtcccttgaa
165601	ggtcacaaca	atgtgaagag	cctggcagtg	tggagtgtca	gctgaataac	ccatgaggac
165661	ccaaggaaca	ggcctggatt	tcttccacag	agcaggcctg	gcgaattccc	atgaagttag
165721	gtcactaggc	aaacgttcca	gggctggcgg	tgtacttatg	actctcaatc	tcccttctaa
165781	gttgttaaaa	aaattaaaat	aaaaaaaaaa	ctcttcagta	cttagacatt	atgctaaggc
165841	agtatctgaa	atgacagaat	ggaatgaaga	gacatcagat	gaatgctaag	tatggagact
165901	atgcagagtt	tagaagttgc	cctgaaaatt	gagagaagct	tagggttggg	gctaatggat
165961	gaggtcagaa	gcttatcaat	cacccaatta	acaagtattt	attgtgacca	tacaggatac
166021	tggatgccac	agtaactgca	tatggtgaga	ggtgtaagac	ctaagttgtc	taactgtgtt
166081	taattcattg	ggaaatttac	taacaggtca	aacaggctta	ccccagtgaa	ataatccacg
166141	tggcatcagg	tcacacattt	ggaaggtgac	cttaaatata	gatgaaggaa	attgttgaag
166201	tcagtggcca	gtatattgaa	ttacaaggct	cataaacttc	tcatgcctca	gatctcgagt
166261	tctattttta	gagacacatt	ttctggcaca	tttgttttaa	aaagtctctt	ggtggggtgt
166321	ggtggcccac	gcttgcaatc	ctagcacttt	gagaggccaa	agtgggagga	ctgcctgaga
166381	tcagaagttg	gagaccagcc	tgggcaacat	agcaagacct	cgtctctaca	aaaagaaaaa
166441	aaaaaatcaa	ctgggcatgg	tggcatgcac	ttggagtcca	agctattcca	gaggctgaga
166501	cacttgagca	caggaatttg	aggctacagt	gacctatgag	tgtgccattg	ccttccagcc
166561	tggctgacag	agtgagaccc	tgtcccaaga	gaaaaaaaaa	aaaggagtct	gaacaaatat
166621	caattctgaa	ccctcttgga	aatcctacaa	tgtctatata	tttttctagc	caatggaaca
166681	gatataaaaa	cttctattgt	caaatgtttg	ttttaaatct	taagagagat	tctttagctt
166741	tgttatctgg	tcattcctca	tttagccaat	aatagtacaa	cttcctagaa	aagaatgaag
166801	atttttggag	gaactgagct	ttcactttgt	ctgcacagtg	tcacagggta	ggcccttgcc
166861	ttcccacgtt	gtggtcatta	gcatgaaatt	gcttggaaag	gtaacctatg	ctctcctaac
166921	tatgaggatg	aaaatggtat	cccataataa	aaatagaaaa	aggtaataaa	agttcacttc
166981	ttgttgcaat	agcaaatgca	caagtagcat	ttatcacttg	actgttttcc	tgtatggttt
167041	tctagtcatt	cgttgctatg	catggagaag	cgtgaacttg	tgaaaatact	tatcatctgc
167101	ttcagtggcc	cattttcaat	gcatttacag	catcaacaat	aacaacatac	aatgactttt
167161	ttttaaaaaa	aaaggtaatt	ttggacacag	aacctatact	atctttatat	ttttgtttgc
167221	tttggctttg	ttttgttttt	tttgaaccta	acaagaagat	ggtagcatta	gccactctca
167281	gttaaaaatt	tgaaaacctt	acagctagag	aaatagtctt	tcagtgactg	aggtacgata
167341	atttcacttt	acgctgtttt	agcttcatta	cattgacaac	agatttttat	atttcttata
167401	catttttaat	tattcttttc	tatcagatgt	tgagaaattc	tatatatcat	gttgcaaacc
167461	taattatttt	taaaaagaga	tttatgtcac	atatgactga	cttcttatct	ataactccca
167521	gaaatactaa	ttttatttgg	aaatacccag	aaagatctgt	taaattatga	atatactgtg
167581	actcatttta	tgcctaatta	taaaaaatga	atgagtaaaa	tatcaaaaaa	atttctttgg
167641	gaaattttag	tttaaaaaaa	gctagtaatt	ttctaacaga	gccttagaaa	taattgtact
167701	cccaatttta	tggggaagtc	atttcattat	taatgtgttt	aattctcaaa	agttagttgt
167761	gatattttta	gtgtaaggtt	gcttggaaaa	tatatgaaaa	aaagatataa	ttattatgtg
167821	aattttatta	tctctccaag	aaagcaaaaa	taaacagaaa	gactaatttt	agataaggat
167881	aagaacatct	aggttctttt	tgctctacta	ctaagcaatc	tttggcaaat	gattttaatt
167941	ttctggagct	tgatttctgc	ctctatgaaa	taaagaggct	agaagtagat	cacatttggt
168001	ggtaatactg	agacRcgctc	tgcaaaaaaa	atgcttcttg	gtcaactgaa	tttggaagtt
168061	atcatatgtt	atgcccacta	tgggatattt	aagatgcaca	ttggtagatt	atgagaatcc
168121	tgcagtaaaa	gaacctactt	atcttggttt	ataccaaaat	ttcccaaagc	tatttggcca
168181	tggacctctt	cctttgtttt	ctttctgtaa	caacatactc	ggaacacacg	ctaggaaatg
168241	ctggcaggat	attcaactgg	gtgcgcctgg	tccctggttt	tcaacacaag	atgatgaaaa
168301	gctgtgtctc	atttttcttt	tgagaaaaaa	atttaaaatt	ctatgtatgc	attaatctct
168361	gattactttt	cctaataata	tcttattttt	cctacttttt	tagtttccgt	gaacaccaaa
168421	agtcataaat	tttatccaca	cactaaggac	cacaatttct	taagtcacta	caacttctgg
168481	gacgctagca	aatcaccact	attaggttaa	gccttcctta	attactaRac	aaatttcaaa
168541	aagcacaaat	gggtaaatct	ctggacatcc	taagcaaatt	ttcacacttc	ttaaataact
168601	gtaacaaatc	agtggccaca	tttactcaac	taatatttat	ttatttatta	tttttatttt
168661	attttatttt	ttgaggcagg	ctggagtggc	acaatatcag	ctcactgcaa	cctccgcctc
168721	ccaggttcaa	gcgattctcc	caactcagcc	acccaagtag	ctgggactaa	aggtgcatgt
168781	caccatgccc	agctaatttt	tgtaattttt	ggtagagacg	gggtttcacc	atgttgacct
168841	ggctggtctc	gaaatcctga	cttcaagtga	tctgccagcc	ttggcctctc	aaagtgctgg
168901	gattacaggc	gtaagccatc	gtacccagcc	tcaacaaaca	tttaatgaag	atatgtcata
168961	cacaaaagca	tgacagatac	tctaaaataa	tgaagaaatt	ctcccctaca	ttaaagaagc
169021	tttttgtcta	taagaagatg	aatataataa	tattttagta	atataatata	tattacataa
169081	tagcaaaaat	atcaatagct	agtgtttatt	aaatgcctac	taatattgca	gatactatat
169141	atccataatc	attcatcttt	aaaaaaaaaa	acccttaaag	cacagattct	attattgttc
169201	tcattttata	agaaggaaaa	aggagctcag	agaggttagc	gatttgtctt	atgacacaca
169261	gctgtcaaat	aaaagaaagg	attcagatca	aggtctatat	gactgcagca	tcacactgcc
169321	tttcaaatca	ggcttaaaca	tgaatgtagg	cagaagagaa	ggaactaatg	agatggggaa
169381	gtagtgccgt	acgaagagga	atacttgata	caactgggct	tcataagaag	ggtcaagtca
169441	agattgctag	gagagttagt	tggccttggg	aaaatgagtg	actgtctctt	tctctgagac
169501	aggaatgaaa	aatgaaagag	gagatggacc	agaagtgtgt	ggagaaaaag	gccttccaga
169561	ctccctttct	cacactaagg	tctgggaacg	attcctaatg	tctgttctct	ccaaggtaat
169621	acgtgtttga	atgtaacctg	cgtttcttac	ttgatatgag	ccctaacctg	aatgtactcg
169681	aggtctctcc	atgaactacc	aagtctatct	aattagttaa	aatattagta	tccatggttt
169741	cttctcagaa	actcagagac	ctaagccgta	gttttttgtt	tgtttgtttg	tttctttgct
169801	actaaaaaaa	acaagcatag	acgacacacc	agaatttaaa	taactaaaaa	ctattctccc
169861	tggcttcatg	agtacctatg	agagtcaaca	cagctcccct	atcttgtggg	aacccttcaa
169921	tcgcaaaata	cccatcttgg	agagtataaa	ttgtgtgttg	gaagtttaga	gaaagggcac
169981	cttccatctc	aatctattcc	aaatgccaaa	cgtgagaatt	tagcttactt	ttgaaatgaa
170041	gtcttcattc	ttaattacaa	acatttcttc	ttgttttgtc	ctagacacaa	agattcctaa
170101	aaagatgtca	aagctggtga	gtggcagctt	agggcccttg	aagatcactg	tgtgtcttct
170161	cctgtgtaaa	ctttacctac	ttaagaggat	tgaggaaaga	gtcccctttt	aacccttcat
170221	cctctcttcc	atttataacc	tttgaacttc	atggggctta	agcaaattaa	agtattagat
170281	tccaccatga	ttcaaggtaa	tgaaaacctt	tccctaaggc	ctcagatgag	ctatagaaaa
170341	taaagaccgt	atgtgaattc	tttaggttca	tgatgtttga	ctcttcaatg	ggtagtgagg
170401	ggggctcagg	gagcatttta	tacagtcctc	atccaaagat	aagcaatggt	ttggtaccca
170461	agagctctgt	gttctagtct	cagctctgct	gcaaattaat	tgcctggcct	tgggcattta
170521	gacagatgag	gttaaatagt	ctttttaaaa	gatccttcta	gttcaaagat	tctaaatcat
170581	aaaactgggc	aaaatggaat	acctccatga	aggaaagacc	caactgaggg	tgtttgcatt
170641	tcagaatgca	atgcacacat	catttggtga	caaacacagt	tttttcactg	aacactaagt
170701	gattaaagag	tgcatacatg	cacactgaat	agacttactc	atggaaatca	cattagtaaa
170761	ttataaaatt	gtatgaaaag	tccaagcagt	gtgcattgca	atagtttctc	aactctgctc
170821	tataaaatga	tggaaatcca	tacacagcag	ttatctctaa	gagagttagc	aattaccctc
170881	aggagtttgc	aagtcaaaag	ttctagacct	ctggatgcct	gggtcactgg	ctgtggcaat
170941	cccaaacact	gtccactcca	agctttggaa	tctgcatcct	cttattttgc	aatagaaagg
171001	agcaaatgta	gtttcccaac	ttggggaagg	tccaggactc	aagaagtcta	ctaaatgtat
171061	ccaagcattt	agaatattat	gggtataaca	attcactcaa	ttaaagagaa	gggcttctgg
171121	tgtttttgtt	gtgtgctatc	atctagtaat	aatgctatat	ttagacatga	ctatccctac
171181	ttatacatct	cctacatcct	gagtctataa	acatttggga	aaatgctggc	ctgaattcag
171241	ggatgaagta	tgaagacttg	gaagaaaaga	aacgctaact	ggttaaatta	caggttgggt
171301	ctgtagtttg	gttttgttaa	atccatactg	cagtatgaga	tcaaaattaa	ctttgtatcg
171361	tagctgccat	tttctactga	tttttgccaa	gagttctaaa	tgttctgttt	tctctccttg
171421	aggaaaattc	ctatttttct	tttcctgaca	cagactttcc	gtcataccat	aggaaagctc
171481	aaaataaact	atactctaag	ctacatgagg	aaaaaaaaag	tctttgtatc	tcttgcacct
171541	ggtatgatcc	ctgatactgt	agatactcac	taaatgttca	ttgaataagg	ctatcaaatt
171601	aatgaattaa	taagagaatc	aagaatttgg	ggatcctatc	acgtaaatgc	atggagcttg
171661	caaatgtctc	atgatttatc	ttgatccttt	gtaaaatgcc	aacttaagct	tgtgttagtt
171721	ccattcggaa	actggcctcc	tagcataacc	ctaaSggata	attataaatc	cacaaaaaat
171781	ctaagaaaat	tctctacaca	atctctttac	caattcagat	cggtcctggc	agacctaaaa
171841	ttttgtgatt	tcctggtatg	gtgaattctc	atcaaatgcc	aacaagagga	tatctagaga
171901	aaaatgttct	gttacgttca	ctgaaaatga	agacagcatt	tttgtttttt	tctcattggt
171961	ttttcctaga	ttacattatt	atagctacag	atcatcccct	cctttgaggg	tcatttccaa
172021	gaaagttcaa	gtttagattt	tcccctcgat	gtctcttaaa	aagcccttct	aaaataagag
172081	atattattgc	ggtcaaatct	actttgcaag	aaataaactt	ggcatcaaag	gaaaactaca
172141	tcattcttcc	cctcaaccat	agtcagtcat	gtctatggca	atcctggatt	caattattag
172201	tgattctgcc	agcatcttga	catttctttt	agagtcagag	ggaggaggga	caaaagtgat
172261	ctatttatat	gctacctcgc	cttttttctt	tccccctctt	tttcctatat	acctaagact
172321	tcagcagtca	gtatccagat	ctcaatttct	cttccttgtg	tcaaaagtta	gggaacggtt
172381	tctgggtggg	tggaagaaca	tcactttaat	tttcaggctt	taagaatctc	aacctcattg
172441	gggataccaa	gaaaataacc	tagaaaactc	cttccacaaa	gtggatggac	acctttcaga
172501	taagcagatg	actcaaagtt	attttatctt	cacgaaagag	ttcattcatt	aaaatgagaa
172561	agttgtttac	tcttgaagaa	ttatttacac	ctctgaagaa	taattatgcc	aagctatgag
172621	aaacctatag	ggtgtgtgtg	taagaattta	tttatttatc	tgacaactgt	ttattaagca
172681	ctgattatgt	gccaggcata	gttctggttg	ttgaggatac	agtggtgaat	aagaccccaa
172741	aagtccctgt	tcataaaagg	aaaacattta	aaaaacaaat	aagtgaataa	tttagtataa
172801	ttccaggcga	tgctatgaag	aaaaagaaaa	gcagagagta	aggatgtgca	tttgtctaag
172861	agagcaacat	cgaagtgaag	accttgagag	gtgacagcgt	gctggcagtc	ctcagagccc
172921	tcgcttgctc	tcggcacctc	ccctgcctgg	gctcccactt	cggcggcatt	tgaggagccc
172981	ttcagccccc	cactgcactg	tgggagccac	tttctgggct	ggccaaggct	ggagcccact
173041	ccctcagctt	gcagagaggt	gtggagggag	aggcgccggc	gggaactggg	gctgcctgcg
173101	gcgcttgcgg	gccagctgga	gttccgggtg	ggcgtgggct	tggcgggccc	cacactcgga
173161	gcagccggcc	agccctgctg	gccccgggca	acgagggact	tagcacccgg	gccagcggct
173221	gtggagggtg	tactgggtcc	cccagcagtg	ccagcccacc	ggcgctgcgc	tcgatttctc
173281	accgagcctt	agctgccttc	ccacagggca	gggctcgRga	tctgcagccc	gccatgcctg
173341	agcccccacc	ccctccatgg	gctcctgtgc	ggcccgagcc	tccccgacga	gcaccacccc
173401	ctgctccacg	gagcccagtc	ccatcgacca	cccaagggct	gaggaatgcg	agcgcagggt
173461	gcaggactgg	caggcagctc	cacctacagc	cccggtgtgg	gatccactag	gtgaagccag
173521	ctgggctcct	gagtctggtg	gggacgtgga	gagtctttat	atctagctca	gggattgtaa
173581	atacaccaat	cagcaccctg	tgtttagctc	aaggtttgtg	agtgcaccaa	tcaacactct
173641	gtatctagct	gctctggtgg	ggccttggag	aacctgtgtg	tggaaactgt	atctaactaa
173701	tctgatgggg	acgtggagaa	cctttatatc	tagctcaggg	attgtaaata	caccaatcag
173761	caccctgtgt	ttagctcaag	gtttgtgagt	gcaccaatcg	gcactctgta	tctagctgct
173821	ctggtggggc	cttggagaac	ctgtgtgtgg	aaactctgta	tctaaatctg	acagggacat
173881	ggagaacctt	tgtgtctagc	tcagggattg	taaatgcacc	aatcagtgcc	ctgacaaaac
173941	aggccactcg	gctctaccaa	tcagcacgat	gtgggtgggg	ccaaataaga	gactaaaagc
174001	acgctgccgg	agctagcatt	ggcaacccgc	tggggtcccc	ttccacactg	tggaggcttt
174061	gttctttcgc	tctttgcaat	aaatcttgct	actactcact	ctttgggtcc	gggttgcttt
174121	tatgagttgt	aacactcacc	gtgaagattt	gcagcttcac	tcctgagccc	agcaagacca
174181	cgagcccacc	gggaggaacg	aacaactcca	gacacgctac	Yttaaaaaat	gtaacactca
174241	ccgcgaaggt	ctgcggcttc	actcctgagc	tagcgagacc	acgaacccac	cagaaagaag
174301	aaactccgaa	cacatctgaa	catcagaagg	gacagactcc	agacgcgcca	ccttaagagc
174361	tgtgacactc	accatgaggg	tccgcggctt	cattcttgaa	gtcagtgaga	ccaagaaccc
174421	accaattctg	gacacaccct	gaaggataag	aagaggaaca	tgagagatgc	acactctcta
174481	atggcaggag	acctgaagac	cctccacagc	cacatggtaa	tacgtggtca	taaaactggg
174541	caaaatggag	tacttccatt	aaggagaaac	ccacctgaga	gagtttgcat	ttcaggatgc
174601	aatgtacaca	actttttttt	ttgtgagaga	gagtcttgct	ctgttgccca	ggctggagtg
174661	cagtggcatg	atctctactc	actgcaactc	cacctcttgg	gttcaagcga	ttctcctgcc
174721	tcagcctccc	aagtggctgg	gattacaggc	gcccgctacc	acactcggct	aatttttttg
174781	tatttttagt	agagacaggg	tttcaccgtg	tcagccagga	gggtctcgat	ctcctgacMt
174841	catgatctgc	cagcctcggc	ctcccatagt	gctgggatta	caggcgtgag	ccaccgcgcc
174901	tggccaagta	cacaactttt	ggtgacaaat	agttttccac	tgaacactca	gtgattaaaa
174961	agtgcatata	cacagaatag	actcactcat	ggaaattaca	ttaataaatt	atataactgt
175021	ataaaaagtc	caagcggtga	gcatggacac	tgcacacaga	gccaggtaga	aggtgacttg
175081	cagagacatg	cacagagcaa	gggcacggtc	caaattgagt	aggtcttttt	aagccaaggt
175141	gaagttttaa	ttttatttta	agtgcaatgg	caaggcattg	aggacttgaa	cagggcgtga
175201	tgtaaactga	tttatatttt	aaaagattgt	tgggggttgg	gcatggtggc	tcatgcctgt
175261	aatcccagca	ctttgggagg	ccaaggcagg	tgaattgctt	gagcccagga	gtttgagacc
175321	agcctgggca	acgtagtgag	acattgtctc	tacaaaaatt	acaaaaatta	gccaagcatg
175381	atggtacgtg	cctgtagtcc	cagctactca	ggaagctgag	gcaggaagat	cacttgagca
175441	caggagttca	agggtgcagt	gagcagtgat	catgccactg	tactcgagcc	tgggtgacag
175501	agtgagaccc	tgtctaaaaa	aaataaaaat	aaagataatt	gtgttttttt	taatgaagaa
175561	agagaggaaa	ctgggagctg	gttaggaggc	cttttcagca	gtttaggcaa	gcaagaagtg
175621	ttagtgaaaa	taacactatg	tcaacaagtc	acgtcactgg	aaacctcctc	ctctgcatct
175681	cattgacgtg	gagattccct	catgggttct	gtcctggagt	tgcaatgctt	caatctcaga
175741	aataagaatc	ctgaacaaaa	gcattctgca	aattaggtct	cacatagtta	gctatgaaat
175801	ttactttttt	atcctctttt	taagcctagt	tagactacaa	ggattttatg	caagcttttg
175861	aaattaaaaa	aaaaaaaaga	ggcaaatcac	atgagataaa	gacacatgat	aaggggtaag
175921	gcaagtggga	gcatcttgtt	gaagcaatga	aagataaata	cagctgagaa	gaaagaccat
175981	gatgtggcga	tttagacaca	ccaagaaatc	cttaacgctt	ccaataaaga	tatggatggt
176041	taagcatacg	aaatacacac	aaaaagaaaa	atattccatt	gaactgtatg	tcaatatatc
176101	atattttcag	cacccaaaat	ctagagagta	tggccaaagR	aaggatcttt	gtggcatttc
176161	tgtgcatgtg	aggcagtaca	ggaaatgtca	cttgcacatg	gaaatattgg	attttccagg
176221	aaatgttcgt	agttctctgt	agacaaagga	acaatattgt	ttaatttggg	accattcaag
176281	gaaattgagg	atatacagca	gacaacgaat	tacatgattc	tcttccttac	aaatagagtc
176341	taccatttca	tttcaccaga	tatcataatt	gtgggatgac	agaaggaatt	ttcatctcaa
176401	cttaatggat	aggaaaatga	agcacagaga	ggtgagaaga	atcactcttc	attcccggat
176461	gaccagctct	ggcctagacc	gccccatcca	accccacatc	caccattcaa	gctgctaggg
176521	cctgatcatc	taaccaatgt	ccataaccag	tcactgcatc	cttgtctttt	gccatcttgt
176581	tccacttaac	agaggaatga	gtttttctgg	caaggaaagt	ggaacagaag	gaaaaaaaac
176641	cctgtatttg	tcaagaaaat	aaaaaagttt	tcaagcaaca	tgtcacacat	acacttttta
176701	cacatgcaca	tttgctcatg	cacacatcta	catgtataca	ctcacatgca	cacatgctca
176761	cacacatgca	cattcataca	caaaccaatc	attcatccct	cagaagcagt	atatgtgtat
176821	atatatactt	tttaatttta	atttttgtgg	gtacttagta	ggtatacata	cttacagggt
176881	acatgagatg	ttttgacaca	ggcatgcaat	gtgtaataat	cacatcatgt	aaaatgggat
176941	atccattccc	tcaagcattt	attttttgtg	ttacaaacaa	tccaattata	ctcttagtta
177001	tttttaaatg	tacaattaaa	ttatacattt	aaattgtaca	tttaaaccca	ccccaccccY
177061	aacccacccc	acttctaacc	caccccactt	ccccttcact	ctcccactac	ccttccctgg
177121	ccctgctaac	catccttcca	ttctctgtct	ccgtgagttc	agttgttttg	atttttagat
177181	tctacaaata	agtgagaaca	tgcaatgttt	gtctttctgt	gcctggctta	tttcacttag
177241	cataatgaca	tccaggtcca	tccatattgc	tgcacatgat	aggatctcat	tggttttata
177301	gctgaatggt	acaccattgt	gtagaagtac	cacattttct	ttatccattc	atctgcttgt
177361	ggatacgtag	gttgagaaac	agtatatttt	tgtcatatta	cttctggcca	tctgagcaag
177421	tactgtccat	gtagtttcag	taaggaatca	agtaagttaa	caagtagaaa	atgaaaccca
177481	ggaaaaaaga	ttaaaaggca	ctgaaatgct	taattctgaa	ggacagaggc	tgaaaaataa
177541	tttcataaca	atctacacac	gtaacattta	cacagaggtt	gatgactgat	tgccaccatt
177601	gtcatataat	tgaatgtcta	ctccacacct	agtacaagta	tgctgatctg	gctctgctag
177661	gaacactaga	ggatgaattt	aaactttatt	atttgaattt	ctggctagtt	atctatatga
177721	aatctggaga	ataaaataat	tgttgagcac	tagaatggtt	tatgccaaat	gagagcttca
177781	gaaagtaaac	tctattcctg	aggtccattt	cagcaccatt	ctctatccca	ctcttttctt
177841	tcctctatct	tcgctgtatt	gttccatgca	cactgccctt	tttttttttt	ttttggtttc
177901	atgccctaac	ctatttcaag	gcataaccta	agtcccacca	tattgaaatt	aaataatttt
177961	cacctttgaa	aaaccccttc	aataaagcag	aattttggaa	tttatagatc	taacatccat
178021	actttcaact	gtttgcaaga	gatttcaatt	atttttactt	ttgttgggca	tgaattagat
178081	cccatgacat	gcaggaggaa	atcacttcct	ggtgagagaa	actaggccac	tgttgaacat
178141	ctacagttta	atgaggattt	gttgttctct	acgcatcttt	gtgcatgcag	taacatctga
178201	acataaactt	tggaattttc	aagtttctta	gtttgtatct	ctggcaaatc	tcaaggatct
178261	actgtaccta	aagtctatct	tacaatataa	atcagagtct	agaaaggcta	taatctgaac
178321	actcttcctt	aggaattctg	gaatctcatg	gcatgcttct	ggttcttcca	tttacMtaga
178381	agaccatttc	ggacagtgag	aaatacacta	aaacttcatt	ttgacagttc	ctggttagtt
178441	aagccaaaaa	attgatggga	aaaacttgtt	ttggggagtt	tagggtcagt	acacaataat
178501	aggtccaata	actctaccaa	ttctacaaga	tgaagaaaac	accatgagag	tgccctcata
178561	ctaaaggatg	aagaaggatc	ccagctctga	accctgtgag	agacagtggg	aaagagttcc
178621	atattcagtc	atggagaaat	gtcagagaag	gagaggtgat	catgcaggag	aagtgggatc
178681	atgtcataga	aatttccaga	gttctgctct	atggaaatgt	agtctaagtc	ctttaaaaat
178741	gatttcttaa	cataaaaaat	aagattacta	ttcagaggcc	aaaaaaattg	ttaccattat
178801	tggcgaggta	gaagtttcta	atctatatgg	tgagcagtgg	gaggtgacat	tctttggatt
178861	agaataaaac	tgactaattt	tgcaaaacta	ttggattgac	taaaagacaa	agtaacaagc
178921	ataaacgtaa	tagtgataac	actcatccct	gattgagttc	tctttatgaa	tcagcactat
178981	acacattatc	tcctttaatc	ctcctaatta	ctgtttgagg	taggtacctt	taagccgttt
179041	tacagagcag	aaagccaaga	cacaggaatt	taaggaaatt	tacaatcaaa	attacacagg
179101	gtgcaagtag	tagagttaga	attcaagcct	acatttgtgt	gatttcaaac	cttgtattct
179161	taaaattact	atgtcctatc	tcttccagaa	aatgacacaa	aggcaaggga	agactcttgt
179221	gttaaagaaa	aaatcccatg	taaatctctc	atattagaaa	aaactaaaaa	ctggccacct
179281	gatgtcaggg	gtggggtgga	gttgagacat	aagagtgaat	cctcaggggt	gactttagtt
179341	agaatggaat	ccagcctcga	attcccaaat	gatagggagg	gccaggaaac	ctaaagtttc
179401	tcttctattt	ttctctaatt	atttaatgtg	tggcaggtga	tctacgtgtg	gtaggttgta
179461	agttcttact	ttgtgggcaa	gtgttcagtc	tataataata	atatttttaa	aagaatattc
179521	aaccttcaat	tgatagattc	tcattcctgt	aagacaagac	attatggcct	tgcagaagca
179581	gaagtcagaa	tactgaccac	agttagtgtc	aaagggcttt	tcagttccca	aagaacttga
179641	gttttagtta	catcctcata	tgtactacac	ttgaccttag	ttatctaaaa	ggatgagaag
179701	cgactgtatc	ctcatatgta	aaaggcatat	tcaggaagag	actcttaaat	tccttggaca
179761	acaaatgttt	tctcctttga	atagctatga	ccttcaccct	tacttttaat	tgtaaacttt
179821	tagagcaaac	aagacataat	caactcatga	tccaaacttg	caaactatgc	atatgtagat
179881	ttatgtaaat	agccatgcaa	atcaggtacc	accactgggc	ttctgggaga	ttgcaaatgg
179941	agcccttggt	acagtagagg	tcaaatatcc	ttggcttaga	gctcaattcc	acatgcagat
180001	ttttacagga	caatggcagc	ccctaaacgc	aacagtcttt	aaatgctgtg	gtaattccat
180061	ggttgaatag	ttttccgtca	taattaggaa	ggggtgacct	ggttcagtga	aaaatgaaga
180121	gcagaatgaa	gttgtgctct	aatattccag	tttatttaag	tttgatactt	attatcatcc
180181	cttctcctgc	cttcctcatt	ttttcactgt	ccattaaggg	acctcagctg	gcatggaaca
180241	ttgctttcct	atttcagctg	cctttgactg	ggatattgaa	tttccctaac	ttacctaaaa
180301	gatgggacag	cccaaggcca	ctatccttga	aaatgcctct	tgccttgaag	cgtgggtacc
180361	ttccctgaga	tgctgcacca	atgatgccaa	ttaaattatc	aaaaactaca	ggaacaagag
180421	aatcttcagt	gactattacc	accactatta	ctaagagcca	cgaactctta	actccgaata
180481	atcaacaaag	accagaggat	ctctccaaaa	aggccattag	actttggaat	atccttgcag
180541	gaccttgctg	gacactcttg	ggaccagact	attactagtt	tctctgtcct	atggcagagg
180601	aacgggactg	tggagtccgt	gggggtgatc	ctaccaaatg	ttagacttgg	agagataaca
180661	gaagccagaa	atgtcctcgg	ccatccatgt	gtgtgcattg	gctattccct	tcacagccag
180721	ggttttgtcc	tcttctactg	cagagttcaa	ttgtagaagg	tagaagttcc	catgagattt
180781	ggtgagtcgt	gggagatggc	attctcagaa	ttgggatata	attgactaat	tctgcaaaag
180841	tactgaatgg	actaagaaat	aaggtaacaa	ccataaaggt	aatagtgata	atactcatcc
180901	ttgattaatc	tgtctttatg	aattagcact	atacacctta	cctcatttaa	tccttctaac
180961	tgcggcttca	ggtaggtgcc	attaagccat	tttacagagc	aagaaatcga	ggtacaggga
181021	atttatgcaa	cttactaatc	aagaattaca	tgggttacaa	gtggtaagag	tcacaggtca
181081	agcctacatt	tgtgtgattt	caaagcttgc	tttttttttt	tttttttttt	ttttttgaga
181141	cggagtctca	ctctgtcgcc	caggctggag	tgcagttgcg	cgatctcggg	gctcactgca
181201	agctcctcct	cccgggttca	cgccattctc	ctgcctcagc	ctccggagta	gctgggacta
181261	caggcacccg	ccaccatgcc	agctaatttt	ttgtattttt	agtagagaca	gggtttcacc
181321	gtgttagcca	ggatggtctc	gatctcatga	cctcaagtga	tccaccgcct	cggcctccca
181381	aagtgctggg	attacaggcg	tgagccactg	tgcccggcct	gtttgttttt	gttttcagga
181441	caaggtcaca	ctctgtcgcc	caggctggag	tgcagtgtca	ccttgaactc	ttggactcaa
181501	gagatcctcc	tgcctcaacc	tgagtagtag	cagggtctac	aggtgtgagt	caccaagccc
181561	agcttaaaag	cttgtatttt	tttttttttt	ttgaaacgga	gtctcgctct	gctgctcagg
181621	ctggagtgca	gtggcgcgat	ctcggctcac	tgcaagctcc	gccttccggt	ttcacgccat
181681	tctcctgcct	cagcctcccg	agcagctgag	actacaggcg	cctgccacca	tgcccggcta
181741	attttttgta	tttttagtag	agacggggtt	tcaccgtatt	agccaggatg	gtctcgaact
181801	cctgacctcg	tgatccgccc	gcctcggcct	ctcaaagtgc	tgagattact	ggcgtgagcc
181861	actgcgccag	gccaaaagct	tgtattttta	atcattattc	tctatgtctt	ccagacaatg
181921	atccaaagta	gtcatttcga	gtagtcggac	ttcgaacttc	accaatactc	cctgcccacc
181981	aacaaatctc	atgcagggaa	atttgaacag	ttcctaatgc	tggccactcc	aaatctactg
182041	ccacacagcc	ctgcctcctt	ttccccaagc	actttgtcct	acagcttgac	acagcaagaa
182101	tattcctgtt	cccttaacgc	atttccagga	ccgtggccaa	tggcagacac	caggtcatta
182161	aacccagtca	cagctgaatg	actaaagaga	ggacatgata	gctttaatta	atttttgcaa
182221	ttgagccctg	tgtttcttga	ataagattat	tacttctgag	ttcctctcaa	ttccatatcg
182281	aaaaaactca	gatcaaaatg	ccaatttcct	tccatgaaat	ggtctggaaa	ataacagaga
182341	taaaaatctg	aaagtattta	caaatatcga	ttgttaagtg	gagaaaaaga	aatgagtgag
182401	tttggaatta	gccaaagtcc	gtgaggagtt	tctgaaaaaa	cgtaatctac	caggagaaaa
182461	gctgtggttc	tagtgatgac	taaattatga	aaataaaatt	aaaagggggt	tgagatacgg
182521	atggggtagg	gatgtaaaaa	gtagaaattg	aagtttgctt	tgtttagtac	agagagataa
182581	ggatttgggg	aagaggggga	tgggataggg	gacattttct	ttaaatgaga	caagaaaaag
182641	taaacaagtt	atgtcatgta	cagaaaggag	aaatgaacca	acatccagct	ttcagtttgc
182701	tggctaacta	tttaggttga	tgcaaaagta	attgtggttt	ttgccattaa	ttttgatggc
182761	aattactttt	gcaccaacct	aatactttca	cttagactat	aaattctcac	ctgtggttag
182821	gtataaacca	tgtaagcact	accaatattt	gaaagagaaa	attgttctcg	cctgtaatta
182881	aaaggtatta	tattctcagt	cagctgcgtt	gtccaagaat	ccattaatca	aagaagccat
182941	tacatctcta	cttagattaa	ttccataatt	gtatcacgtg	agttatgttc	aaacatttat
183001	tgcccaataa	ttttcagaga	aaaatgtaat	aacttgggtg	gagatRtcat	taatgggaag
183061	agatttttgg	caagcaagtt	aatgaaatgc	atgaactaac	cctccaaccc	caattataat
183121	gaacttttcc	aagttccagg	gctaatgggt	aagctacaaa	cgctgtaaat	gagcttgcta
183181	gatttgggca	gccctctgtg	aatgtcaatt	tagtcctaga	attttgcaag	gataatttca
183241	agtgaacaaa	acctggacat	cttcctcatc	ttccaaaaca	ttcaaggcag	ttcttgtatg
183301	cccattaatt	ttttagcaac	aacttccatt	cgatctctgg	ataaaaggcc	atctttatat
183361	gaaaaaaatt	acttttcaaa	acaggcagta	ggtagttcct	ttttaaaatc	tcatgttgta
183421	aaacaatatc	attccaaaaa	taattctaac	aagactttat	aggctctcgt	aagagaattt
183481	attatgtatt	gccttttatc	accgtgcgtg	tcaaacagca	gaattatgag	ataaatggta
183541	atggtagtca	tgtgatattt	gctttaggaa	atctaaacaa	ttgtaaaaag	acactgtact
183601	tctatcaaat	acctaatact	tggttccaga	cttgaaatgc	cagaggttta	ctgcaagtct
183661	gagacagaaa	agaaggatta	aaaatgataa	aattaggatt	tgggcacagt	caatcataac
183721	atcttaacat	ctgacgtgac	ctctggagtt	atctgcacca	gacaagctct	cccagtcaga
183781	gatgaggtga	ggcccacagc	tgaggaatcc	aattgcccca	gcttcagaga	tgagtggcat
183841	Stgtaggaga	aaatccgaca	ggtccacagg	gaggggtttt	tattctttag	caacagaata
183901	ccagcagaac	acgttttatg	taaaatagcg	gatgaaatcc	caacctataa	ttgacacaga
183961	atggaaatgc	ttgggtagaa	ggtggagaag	aggccctcat	ccacctggca	ctgctctcca
184021	gctccctgca	atttctctgt	ggggagttat	cagacactta	ggtcttgggg	aaaatgcatg
184081	agttaggact	tctctggttg	caaagtaaac	aattcgatct	gagtgagaat	tacatccagg
184141	aaaataatga	tggttattct	aataatggtc	tcatggaccc	agaggagcaa	tgcatgtgga
184201	tttgaggaag	ggactacaat	tgggatggtg	gttatcagat	ctcgctctct	ctatttatat
184261	atatatttga	gacagagtct	ctgtcaccca	ggctagaatg	cagtggcggt	tcactgcaac
184321	ctccacctcc	tgggttcaag	tgattctccc	acctcagcct	cccgagtagc	tgggattaca
184381	aatatgcacc	accacactca	gctaattttt	gtacttttag	tagaaacagg	gtttcaccat
184441	gttggccagg	ctggtctcca	attcttgacc	tcaagtgatc	cacccacctc	agcctcccaa
184501	agtgctgaga	ttagacccat	gagccaccgc	acctagccct	ccctcccttt	aaacacacct
184561	gtgcacttct	aaattccata	ggacaagaat	ctgatgggcc	catgttgggt	agggcccatc
184621	aattacattg	ggggcttgga	agtggcagtg	tagagagaag	agggaggccc	agggtcatat
184681	gacagacaca	tggctggcta	tgatttaagt	gtcagtttcc	agagaagaag	aactggtcag
184741	gcccccagca	atttggaaac	tactgatact	gtgtctggaa	ttggtgggtt	ctcggtctca
184801	ctgacttcaa	gaatgaagcc	gcggaccctc	gcggtgaatg	ttacagctct	taagatggcg
184861	cgtctggagt	tgttcgttct	tccaggtggg	cttgtggtct	cgctggcttc	aggagtgaag
184921	ctgcagacct	tcacggtgag	cgttacagct	cataaaagca	gtgtagaccc	aaagagtgag
184981	cagtagcaag	atttattaca	aagagcaaaa	gaacaaagct	tccacagtgc	agaaggggac
185041	cccagcgcgt	tgccactgct	ggctcgggca	ccctgctttt	attcccttat	ctggccccac
185101	ccacatcctg	ctgattggta	gagcctagtg	gtctgttttg	acagggtgct	gattggtgcg
185161	tttacaatcc	ctgagctaga	cacaaaggtt	ctccacgtcc	ccaccagatt	agctagatac
185221	agagtgtgac	acaaaggttc	tctaaggccc	caccagagta	gctagataca	gagtgtcgat
185281	tggtgcattc	acaaaccctg	agctagacac	aggctRctga	ttggtgtgtt	tacaaacctt
185341	gagctagata	cagagtgccc	attggtgtat	ttacagtccc	tgagctagac	ataaaggttc
185401	tccacgttcc	caccagactc	aggagcccag	ctggctttac	ccggtggatc	ccacaccggg
185461	gctgcaggtg	gagctgcctg	ccagtccagc	gccgtccccc	ggcactcctc	agcccttggg
185521	tggtcaatgg	gactgggcgc	cctggagcag	ggggtggtgc	tcatcgggga	ggctcgggcc
185581	gcacaggagY	ccatggggga	ggggggaggc	tcaggcgtgg	ctggctgcag	gtcccgaacc
185641	ctgccctgcg	gggaggcagc	taaggcccag	cgagaaatcg	agagcagcac	cggtgggccg
185701	gcactgctgg	gggacccagc	acaccctctg	cagccgctgg	cccgggtgct	aagcccctca
185761	ttgcccaggg	tcggcagggc	cggctgctcc	gagtgcgggg	cccaccaagc	ccacacccac
185821	ccggaactcg	tcctggcccg	caagcaccac	gcgcagcccc	ggttgccgcc	ggcgcctctc
185881	cctccacacc	tccccgcaag	ctgagggaga	cggctccggc	cttggccagc	ccagaaaggg
185941	gctcccacag	tgcagtggtc	ggctgaaggg	ctcctcaagt	gccgccaaag	tgggagccca
186001	ggcagaggag	aagccaagag	cgaaagaggg	ctgtgagaac	taccagcaca	ctgtcacctc
186061	tcaatacgct	gtgctggcag	tggccacaca	tacatactag	aacgagacag	gcccaactga
186121	gctgcaggaa	gcatagctca	ccaagctggg	catctgagca	tggtacagag	caccatgact
186181	cccagtggtc	agttcaggac	aggcactggt	tttaccatct	ggggagccca	caaggatcag
186241	ggtagtatcc	aagactccag	acagcatggg	aaagcagaga	gtcagtgata	tggtttggct
186301	gtgtccccca	cccaaatctc	acatcgaatt	gtaataatct	ccctgtgtca	agggaggagc
186361	caggtggaga	taattgaatc	ctgggggcag	cttagccaag	gtgcagagtc	tgaggtctag
186421	ttctgctgac	aggaagagca	ggcctccatc	tggaaagaac	tggaaaccag	gagagtggcc
186481	tctaaataaa	cagaaattga	aggagacaga	agccttattc	ttatcctaat	tgagctctgg
186541	ggtcagggga	aagaagcagc	aagattattg	ggacagtgaa	tcccatgagc	taccaaccta
186601	ggccttccca	acctctgacc	agagcaagat	tgccttctgc	tttctgggtg	tgagtgctag
186661	gggagcctgc	aggaggaggg	gaatttccta	tgaggttgtg	gcgtctacta	gaaggccaca
186721	atgatcaaaa	gggtcattag	agcttctgct	tgctctgaat	ggtatttgtg	gagagggaat
186781	gtgccttatg	ttctctcttg	cacagtggtg	gtgtctccct	tgacccttcc	taacaaacac
186841	ggtgagtgaa	ccatgaaacg	agaaaactat	caggcatcag	taatacgtaa	ggcctgggcc
186901	aaaataaaga	gttatgtgtt	gaaaatgaac	taacgcaact	ggtagatact	ttccatgcta
186961	acacttttgt	agtctcaggg	tttataaaaa	tctttctttc	tttctttctc	tgtctttctt
187021	tctttctttc	tttctttctt	tctttctttc	tttctttctt	tgtttctttc	ccttccttct
187081	ttccttcttt	ccttctttct	ttccttcttt	ctctctttct	cccttcctcc	cttcctccct
187141	tcttcccttt	ctttcttcct	ttctttcttt	cagcctgggt	cttattctgt	cacccaggct
187201	gtagtgcagt	gtcataatca	tggctcactg	caacctggaa	ctcctgggct	caagggatcc
187261	tctcatctca	gtctcctgag	tagctagcac	tacaggcacg	tgccaccaca	ttgggctaat
187321	gttttaattt	ttttgtagaa	ctggggtctc	actatattgc	ccagactgtt	ctggaactct
187381	tggcctcagg	tgatcctccc	acctcggctt	cccacaatac	tgggattaca	gacgtgagcc
187441	accaagcctg	gccagtttac	aaagatttct	aaagaaagat	cccaggaaac	aatttcaagc
187501	atcgctccta	catgtcactt	tgtgatattt	ttcatgcata	gaaggaataa	tacattaagc
187561	ctgcgtgcat	ctcagtgcgg	tacatgtttt	actcatttgc	ttaatttgct	gaagatttta
187621	atgtcacgtg	gctgcagaga	gggacatgga	aacacttaga	aggactcagg	gctttaacat
187681	caaacgccca	cttttgattc	tcctgccaag	aaagaacaaa	atatttgtct	ctcggatagt
187741	taacctctct	tccatacaca	gtccacaaca	cattgcattg	gcaagctata	tgcaaccccc
187801	ttctcctcta	taaaggatgg	taatcttttt	gcttacaaag	atgagaaaca	ccaggaacac
187861	ccatcattct	ccaacaaatt	agcttgtctt	gagactattt	tccatgtaat	ttaagggtaa
187921	atgtcagaga	agtgtttccc	tttattggaa	gtaaggagct	aaagttctaa	atgctggtaa
187981	gaaatgcagt	ttgtaactcc	ttcaggcacg	gggtctttat	ctgccctgaa	tgatcttcta
188041	gtgcccagga	ttcagtgtcc	agggaaggaa	tagacacctg	tctgtgtaac	ccaagggtga
188101	cagagcttag	catctttttt	ttttcaattt	ctttcttaca	tccaaagact	ctggatatct
188161	tacatataaa	ccaacccaag	ggttttctga	catattttgc	ccaagttgga	gttatacaca
188221	tgtgccaatc	accagtgaag	ggtgattact	tattcagtag	aaaggagctt	tgaagaacgg
188281	tgggaagtag	ttctgtataa	atgacacatt	ttatctgttt	ttcaaataat	tcatggaaaa
188341	tactgacata	aagtgccaat	tattttttcc	ccatgaatag	ggctggcagt	cttattgtat
188401	actttaaaag	tcacttacaa	tttgctcaca	tttcttaact	ccccagggaa	aagaatgtat
188461	ttcctttgct	ctaaagatta	aagttcaatt	tgacttcata	ttttgtggaa	gggattctta
188521	aaggcattgc	attctcatat	cctagatatc	attacaagct	gtaaatttgg	tgattgatgt
188581	ctacatggca	gcctccagag	gctgcgtgct	agttaaaata	ataaagtgct	ccttagcctc
188641	tagatgcatt	cgagagaata	gcaggtggtc	attgtttact	gtgctaaagt	gagccactcc
188701	gtttgagaca	gctcattttg	gactcaagct	gaatgccatg	cctgagtgat	ctgacttcta
188761	acaaagccac	caatagactc	attctgttgt	ttaatttgaa	tgagaattag	ctgctgcttc
188821	gtgcaagcca	aagaccctct	attagaaact	ggttctctag	aaatgtttat	ggaagcccag
188881	tggctgcagc	attttggagg	ggtgtgagaa	tgatctgatc	ttccatggaa	gcacattgca
188941	tttccaatct	caccattcca	cttcagactc	aagcagatgt	ggcagggaga	ggcggtaata
189001	tattttgcca	tatgtcaggg	ccactgtgtc	actcagactc	ccaggaaatg	acacagactc
189061	agggaaaaca	gtggcccata	tattttcatt	aaaaagagag	catgtgactg	gttcacagtc
189121	agggcaattg	acacagaccc	cttctccaag	agcgttatat	taatattagc	aagagcacag
189181	ggccacggct	gctgaagttt	tagtccacag	agtcaagaaa	gcacaaaatc	caaaaagctg
189241	ggatttgcaa	gacactgttc	ccaaaagcag	tctccctgat	aggtttgcac	aaaactcttt
189301	ggggtaagca	gtaactgtac	ccttcacact	gtggcaggtc	cagccacagg	caacatagaa
189361	cattctagcc	ttgcatctta	aaacatgcct	tttaataatg	tgacctggag	aatctgagtt
189421	caacatacag	agtgtctgaa	cactttagaa	gtgatttatc	agggtcctag	tataagaatc
189481	gaggcccagg	cagaaccaaa	ctgcctgctt	ctaacaactc	cttttcgaag	gaccagcttg
189541	tttttatata	tttctttgtg	atattgctcg	gaatctgtgt	ctccattcag	aaacccatcc
189601	agtatctatt	ttttttcaaa	aagaagacag	accatttgtc	taagatcaga	tgagcgtgat
189661	ggaggacaca	aacattatga	ttgaaatata	atcaagatat	taatgcaatc	ggtactgttt
189721	ttagaagaaa	aaaattgatg	ccataattca	gggtcaccat	ggcaatcctt	atttgcttat
189781	taatttgtta	ctactttaaa	gttttcctct	tggctcattc	aatgtagcct	ggcaaacatc
189841	cataccttgt	ttctcatggt	gtttatttgc	tcattccatg	atttttacca	atgatgctgg
189901	gcattttcaa	gattcagcct	aacaatgtac	atggacaggc	ttagtctcct	ctgggatttt
189961	ctgcctggga	tgatgcaatt	tccaggagct	cattacacca	taaaggagac	gcacgcccct
190021	tttcttagga	aacaatcttc	tgtctgttgg	aggtctcttg	ctctccagtt	taaaaagctt
190081	taactgtgct	ttaagacttt	gtcattcaat	tcttatttat	tcttcttaat	ctccttggga
190141	ttcttacatt	aggtgtacaa	taatcctgtt	aagccctcaa	gacttctcct	aaatgagtgg
190201	cagttctggg	taatggattg	aaatatccct	tgcattttct	agaaacactg	tatcttgttt
190261	tatgatcgtc	gttttctggg	agtcccagct	aatttaggaa	gtggggaaaa	gaaaacattt
190321	gctgaatctc	agctgagaac	aacacgaaga	tgatcatcct	agggaaagta	caaagtatac
190381	aaaaataata	caaaaaggca	Sgtttctctc	cttcaaaaag	aaagtcccca	tttattcttt
190441	cccagtgaag	tctctgactt	ctgaactctc	tgactactcc	caggcagttt	gatgtagttc
190501	tcttttcatt	gttgtggata	caatggtgaa	ccttggataa	tggtgtgcct	cacagaccag
190561	gcaggaagtg	agaacctgaa	atctgcagaa	gcagggtttt	tagaaagcgg	tagaatctta
190621	acaggcgaga	agtcaaaagt	cagaatgcaa	gggtatcaag	gtgaagtaag	acagaggttc
190681	agcaaccagg	aaagaacaca	atgccacaag	ttcccaggtc	aaagaaagac	agagggtcag
190741	caagctgttg	ggcatctagg	actctactca	tgagacatgt	ggaacagagc	ttgtaattca
190801	gcctctgtga	aaaagccctt	gacatgattt	ctgctgtgga	aggagtcatt	ttcattgtat
190861	ttgcagccca	gggactgaaa	ataagggctg	atgatgatgg	gaatataata	gaatgctaag
190921	ctgggtgtgg	tggctagcgc	ctgtaatccc	agcattttgg	gaggctgagg	taggtggatc
190981	acctgaggtc	aggagtttga	gagcagcctg	gccaacatgg	taaaactccg	tctctattaa
191041	aaatacaaaa	ttagccaggt	gtggtggtgg	gtgcctgtaa	tcccagctac	ttgggaggct
191101	aaagcaggaa	aatcgcttga	acccgggagg	cagagttcgt	agtgagctga	gattgcacca
191161	ttgtactcca	gcatgggcaa	ccagagtgaa	actctgtctc	aaaaaaaaaa	aaaaaaaaaa
191221	aagaatgcta	aaagggctct	attgaaaaag	tatatttctt	acaacctcca	ctacttaata
191281	tagaccccct	tcctgtattt	gttcattttt	taaaattccc	agaatagatt	actgcaaagt
191341	ttccaacttt	cagagatctt	taaggccatc	tggaagcttt	ggatataaga	catatctaat
191401	cttaaagcac	atcacccaca	ttagcacatg	aagttctgct	gaggaattta	ctcagtcctt
191461	ctgagcttca	aggaacaggt	taattccaat	gcctttgtct	gaaaaaaaat	ggatccttcc
191521	tttctagagc	tttccctggc	aatgaccaat	atcacaagaa	cagagccctt	ctcagacagc
191581	attgcatcag	cacgagcata	gggccatggc	tgtccaggga	gtcaagaaaa	cacaaaatat
191641	aaaaaacctg	agatttgcaa	gacattattc	ccaaaagtag	cctcctggat	tcttttgcat
191701	aagactgttt	gggatgggca	gtaagtgcag	ccaggacact	tgcaagtcca	gccatgagca
191761	acatagaaca	ttctagcctt	gtaccctaga	acatgcattt	ttataatgtg	atctggagaa
191821	tatgagttca	atacacaggg	tcggaaagtg	ggagctaaga	caggaaggag	gatagggtgg
191881	aactcaaaaa	caagacttag	gtggtgatgg	agaatgctaa	aattttagcc	atataagtac
191941	agaaaaaaat	agacaataac	acatgtatgt	atctatttca	acagtttctg	ggtgtttaca
192001	gtgtaccgag	cactgtatat	ttgaccagat	accaaagaga	gtcggtgaga	aaaataccag
192061	tggcctctaa	ccatctctgc	attcagacag	caagaaagtt	ttgagagaaa	ccaggatatc
192121	taggaaacga	tccagacagg	tttggaaaga	tagtcctttt	agacacagca	cttcaggaag
192181	tatatgttaa	aatggcaaaa	gctctagatt	gaagtctggg	tttcagtttc	ggttttagaa
192241	ttttgagcaa	gtctctaaat	tttactggct	ctctgtttct	acttccatag	acacgatgct
192301	ttgttaaccc	tggaggaagg	acatcattgt	cctgcaggat	gctgggtgtt	gttatgaatg
192361	caagagccag	caggggatgg	tacagaggat	gcagagacca	actctcccta	agagctcaaa
192421	gcagcttcac	aagcatttga	actgggcctt	gaacagtgag	cacaaattct	tcaggcaaac
192481	agagatggta	agttgtctat	ttctggcagt	gaatagagaa	aatagcattt	attaaggtcc
192541	tgaagaattc	atgctttcat	ccatttattc	aacaaatatt	tagtggtaat	ttattaataa
192601	tgaacaaatt	attagttatt	attagttatg	ttgattatta	gtattattaa	ctgacactgt
192661	tgtaggcact	ggactacagc	aataaataag	gcacaccatg	tatctgtcct	caaactctac
192721	aatccagtgg	cagggaatga	aggaaactga	ggtcaagtta	tgcaaagtga	accagagatg
192781	atgcacaaaa	ggatgatgct	ccggcagggc	atggtggctc	acgcctgtaa	tcccagcact
192841	ttgggaggcc	gaggcaggtg	gatcataagg	tcaggagttc	gagaccagcc	tggccaacat
192901	agtgaaaccc	catctctact	aaaaatacaa	aaaaaaaaaa	aaaaaattag	ctgggcatgg
192961	tagcgggctc	ctgtaatccc	agctactcag	gaggttgagg	caggagaatc	gcttgaacct
193021	gggagacgga	ggctgcagtg	agccaagatc	acgccactgc	actcctgcct	gggcgacaga
193081	gagagactcc	atctcaaaaa	acaaaacaaa	acaaaaaaat	gatgatgccc	catggatggc
193141	tcgaaccaga	aataggtaaa	gatgagatcc	aaagtggtac	tgaagacatt	tcagatttat
193201	taactacaca	caaagagtag	ttggggcttt	tgaggttttc	tgtttatcca	ttcagaaata
193261	tttactgaac	acttgatgtt	tctgacactg	ttctaaaatc	tttgcatgca	tatttccgtg
193321	gcaatcttgc	aaggtaagaa	ctattccatt	atcattttat	aatacatacc	aggaaatgag
193381	cactgaaagg	catgagtact	atgcctacgg	ttatatgata	ataaggagta	tatcttggat
193441	ttgaacccag	ctcgggctaa	ctccaaagcc	ctttctcatt	ttactacatc	agtgaatcac
193501	accaggctga	tcatagcaga	atttattgag	ggaggggccc	atgtatcagt	attaattttt
193561	ctatgattta	tttatttatt	ttaatacaga	tggggtctca	ctatgttgtc	caggctggtc
193621	atgaactcca	agcctcaagc	aactctcctg	cctaggcctc	ccagagtgct	gagattacaa
193681	gcatgagcta	ctacatccag	cttcagtatt	tattttattt	tattttattg	tagtttagtt
193741	ttttttagtt	tagtttagtt	tagttttgag	ataggatatg	gctctgtcac	ccagactgga
193801	gtgcagtggc	gtaatctcgg	ctcactgcaa	cttctgcctc	ccggtttcaa	gtgatcctcc
193861	cacctcagcc	tcctgagtag	ctgggactac	aggcacatac	caccgcacct	ggctaatttt
193921	tgtatttttt	gtagatacag	ggtttctcca	tgttacccag	gctggtcttg	aactcctggg
193981	ctcaagcaac	ccttctgccc	cagagtccca	aagtgctgga	attacaggtg	taagccactg
194041	cgcctggctc	aactttactg	tttttaaaaa	gatgtctagc	tagttccagt	gtgcacctag
194101	gctagggaat	agttgcccta	tataaaaagc	aaaacacaaa	caaaacaaaa	ccctcaggat
194161	aactacctac	tgatttaaaa	tataagttgg	cattcattag	catcttgctt	attttactca
194221	tgtaatgatt	tgcttggatg	cccaggttga	tgggaaaaag	gggttccatg	tagttgaaaa
194281	acctagacag	tagtcaacat	gcaggcacca	tgctcgttcc	tcccctgaca	ttcaacgcta
194341	ggttgagatc	acatcgttac	atgggataac	accgtctttt	attgttcttt	tattgctatg
194401	tgatctcctg	aactgtgttc	ctccaactta	gaatttaaaa	agaaacattt	ctgggttctg
194461	cctagtaaaa	cataaatctt	ggaaaatcaa	atcccaacta	gagaaatctg	gtttggatca
194521	gagtaactaa	atcattaatc	tggatctttc	tccaaaactg	gaacccaccc	aaatccaatc
194581	catgatatat	atgaaagagg	ccagatattt	agatggacat	taattctttc	tttttgttga
194641	tgtgtttgtg	ctgacagaag	agtcagagac	caaaggcaga	atactgaaag	attgtgtttg
194701	ggtattttta	gcctgattaa	aataaggaat	gatttaaaac	tatttcaaat	agctcttccc
194761	acagaattct	gcaaatcttc	cagcctgctt	tctggaccag	agaagcttgg	ctaaaggagc
194821	tggacatcgg	gcaacccctc	ccatttggat	tgagcctcca	acattcagag	gttgcacccc
194881	atcagtctaa	acaacatttt	tttYtgcgtg	atagaaacac	agaccacaga	ttggaattgt
194941	ctgtttgtac	ttagatggga	agtcctagca	gttctcatca	acccttgaag	acgttaaaaa
195001	tcacgccaca	gttggccaac	cgtctgttta	cctcttgaag	aactctctca	gatgacagta
195061	atcacaggca	ggttctgaat	cacaggctga	tgttaacatg	taccaaggct	ataccccctg
195121	gaaaagccta	tttccagcct	tctgaggcta	cttcattact	accctggctt	tcctggctcc
195181	taatggtcag	ggtggaggga	gggacggagg	taggggagat	ctgggaagcc	tggttagcta
195241	gaagttcctg	ccttgtcaca	gcactaatcc	tgcaatttct	ccattggatt	tctggactga
195301	tgagcaattt	tgatgctgat	aaggcagaaa	cacaatcact	ctcctgggcc	cttgtatttt
195361	gcagggtaac	ttggataata	caccccatct	cggcacctct	gcgagtgtaa	ctcatttcct
195421	ctgcccagag	gagaaacaag	gactccttgg	acaaaacggt	gcttcctttc	atagccaatg
195481	aattgggcat	ttctccaggt	tctgtgaagc	ttatttagtg	acattcccca	aaacctgtgc
195541	cccgagaagt	tccttcttct	ctgactttag	gtagagtccg	agattcattt	cagtgatttg
195601	gctaacatgt	aaagtgtctc	acatgtgaaa	gagaatcaaa	ataacttgag	cacaacaaca
195661	gacaaacaaa	agcaatactt	gaccaagacc	tcttgtactt	tttctgctct	gggactctcc
195721	aagcactgtt	cacaaatgca	gtgtatgtgg	aaatctatgg	tattgttatg	atctgtcagt
195781	gatggtgcat	attaaaaccc	agttttagtt	aatattcact	catagccttt	gcttgttaat
195841	atttacacac	ttggcttaga	agatagaaag	gctcggccag	gtgtggtggc	tgacgcctgt
195901	aatcccagca	ctctggaagg	ccgaggcagg	cggatcacga	ggtcaggaga	tcgagaccac
195961	cctggctaac	acagtgaaac	cccatctcta	ctaaaaatac	cataaaaaat	tagccgggag
196021	tggtggcggg	tgcctgtagt	cccagctact	caggaggctg	aggcaggaga	atggtgtaaa
196081	cctgggaggc	ggagcttgca	gtgagctgag	atcgcgccac	tgcactccag	cctgggcgac
196141	agagcgagac	tccatctcaa	aaaaaaaaaa	aaaaaaaaaa	aaaagaagat	agaaaggctc
196201	aacagaattc	tacagaaaga	aactcgaacc	atccaatcat	gacgttagcg	atgtgttgtc
196261	tctaatcaag	ttacctgatt	acctaggtaa	caggaggcct	Yagcagtcac	ccctggcacg
196321	catggaccac	ttactggcaa	ctcttttgtg	gctgtgaatt	catatagtat	ttggttaaat
196381	ggtgacacaa	aattgatccc	tagtgcgata	ttcagtggat	ttttctcatt	tctaaatggg
196441	cattccacac	tgaaaacttg	catgccagtt	gcccatacag	aatgctcttt	tattctttaa
196501	gaatggaaaa	taagtcattt	tcatttgatt	cagagtggac	aacctcacgt	ggggacagga
196561	aagtctaacc	agagatttca	actggggtgt	ctgaagtgta	acttgctaga	tacatttgga
196621	actatcagac	attctatctg	ctatacttag	ggtagaggga	ttaagcctgc	atattcaaga
196681	atgaaactcc	agcttttaag	cctagcttat	tattttatgt	atgtgggcaa	attagttagc
196741	ctctcaaaac	cttagttact	tcattttaaa	aataattata	ctgtaatccc	agcactttgg
196801	gaggctgagg	tgggtggatc	acctgaggtc	aggagtttga	gaccagcctg	gccaacatgg
196861	tgaaacctca	tctctactaa	aaatacaaaa	attagccggg	tgtggtggca	tacgcctgta
196921	gtcccagcta	cttgggaggc	tgaggcacga	gaattgattg	aacctgggag	gtggaggttg
196981	cagtgagctg	agatgaagcc	attgcacttc	ggcctgagtg	acagagtgaa	actctgtctc
197041	aaaaaaaaat	aaaaataaaa	ataattataa	aatagaatcc	gcagtgaggc	ttaggcaaga
197101	tcaactctgt	caagtggctc	gcattctgtg	cattgcacaa	gtggtaaatt	cgattcaata
197161	aactatctat	tgttatcatt	ttattattac	taaatgtgct	taatcttgag	aggctgctgt
197221	aaaactcagt	ggcatttctR	gtcttaaagc	tggtttcaaa	aggaaacttc	tccattcgca
197281	ttatgacatt	taaagttgtt	tctctgaggc	tttgggaaga	tctccaagtt	ctcctaacac
197341	aatagagatc	atttttatac	tccctgtaac	acctacgtgg	ttagaggaca	agaactgggg
197401	atctttatta	Ktccagagtc	tgtccaagtg	atgtcaagga	tcctgagttg	ggacaagaaa
197461	gtagggttac	atgccccaca	tcctactgct	acattttggg	cttcggggct	cttggtctgc
197521	tcagggtttg	cccgggctgc	aaagtagtgc	tggctcatga	ctctaataac	tgcattaacc
197581	atgtcctcct	ccttccatct	caaggttgcc	cagtgggaat	tgtgaatgcc	gggactctgc
197641	atttcacagt	tagtggatct	ggctaaatag	atggagtaag	tgggcttaat	tgatttttcc
197701	ccaagttgag	acttggggta	aagaggcaag	aatgggtttg	tagtgaagaa	tcaacttacc
197761	actgtcaaca	tgcgataaga	aatctaaaag	attttcattg	ttcactaaac	aagacttcag
197821	ctgggactcc	ctctaaaaag	caacaaactg	tgattagagg	agtcccaaag	gatgatacga
197881	gctaagataa	atgagctaag	acatgttcta	tttgaaacat	ttgggtcttt	cttggcaaga
197941	gacatactct	tatcttgata	gtgtctcctt	tccttttcaa	tttttattta	ttataaacaa
198001	agattatcct	cagacttgaa	tctgttttgc	caggatactc	ccctccaaca	ttttgtcctt
198061	ttccactgct	tcccttctct	tttttttttt	ttaaactata	ggtatgtaat	aggaatttcc
198121	ttccttcaag	taattgattt	atttgtgctg	acatcatcaa	aatgtctcaa	catgaatttg
198181	atttcatgtc	taagatgttt	aagaatacat	atttcttacc	cttaaaaaca	gaaagtcatt
198241	ttttttttta	gtaaagtaac	tcacccctga	aaaacttggg	ctctgttcaa	aattcccaac
198301	atgtgacttt	gaggatcatc	taaaagagtc	tctcctggtc	tttcaccata	acgttcccac
198361	ggtaaattca	ctaaaaacag	aaatgctcaa	tatataagtt	aaaaaccctg	tcaatttgac
198421	ccacattcga	aatgtttcag	tgtatccaga	acacatctgg	accaaggtgg	gttgtttttt
198481	cctccttaaa	aaaaaaacga	aaaaaaaaac	cctcactcgt	ttatgtcttt	atatcttaaa
198541	caaaatgaat	taRtggcttt	taaacccttg	aagcactaaa	aaaggaaagt	gctttcagtc
198601	tgacaacttc	aatgataagt	tgcagtccaa	tgtgttttga	aatggaccaa	acataaatcc
198661	atcttcaata	gggagtttta	attggaagcc	acactgaccc	ttaactccag	tgttgctgcc
198721	acacagcttt	tgataatgaa	gactgacaaa	ttgtcttcac	tggatgtaga	ctttcaatgc
198781	actcctccca	cggccttggc	cgcaccaggc	attgggaagg	agacgtgcat	ttcccaggtg
198841	tgagaggaca	acagaggtcc	actccaagct	actggacagc	atccccctcc	atgggggaag
198901	caggtgcctg	aggaggaaag	ggtgctggga	gagaatcaca	catatctgag	cagtgggaag
198961	cccagggaaa	cacctctgaa	gttaaaaaga	aggaggatgt	caggggagag	agaaagaaaa
199021	gaaaccatct	ttcttatgga	gaattccatc	tgcttgtggc	ctgtttggga	actaagttat
199081	agaatgtttt	tgggcttcct	aagattgatg	tgggaggggt	tgcagatctc	atgcagagct
199141	ctgatgattt	tttttttttt	ctgaagaaca	gcaaaccaga	aaacaacggg	agtttgtagc
199201	ttagagagtg	ctgttgagca	gagattgtga	tattgagacc	attccaggag	aggaagtttt
199261	aaggccaaaa	ttaaaataRc	acatttgttc	cttgcaattt	gacttcagaa	tcccccaagg
199321	ctccttcctt	gagaagcctt	attttttatc	tgagagatgt	tgtgcaccat	atggattttt
199381	tttttttttt	ggtttacgtt	ctgagtttgc	caagaatgtc	ttatgagaca	cagtacctca
199441	ttttccatgg	gtgtcccaag	agatatcagg	taccttcaaa	gctctctgta	tttgctctgg
199501	taaatgtaaa	catgcagaat	aaaacaacac	tatttagcaa	ataaaatgat	actctcataa
199561	cttttaagct	gtgcaaagca	taattactgc	aatctcaata	attattatca	cttaatgttg
199621	aaagagcacc	aaccttcatt	cagaagcaaa	ttaaaattgg	aacccagcct	tgacattcat
199681	ctattaagac	tcaaagcctc	aacagaaggc	atatacatgt	ttgaacattt	tgactgaatt
199741	Yacaggtgaa	ttcaatcaat	gtgtcagttc	cYactgaact	ttcaagttga	ttgactacat
199801	tgattgaata	agttgaccta	ttgtgttgtc	agcttggaga	cttagccatt	gcatcatcat
199861	ggaagtaggg	agttagctat	gggactcaga	cctcagtgag	aaaggagaaa	tctggagtag
199921	ctgagtatca	gtctctttgg	aattcttcac	atttgttact	ggtatgatgt	tggcaaccct
199981	caaaagaatg	aatccattaa	agtggacttc	cagtggagtt	gtagaagtgt	tgaatttaag
200041	gggaaaacat	tcaaccctcc	actgacaagc	tcctttagac	ttctttggct	tcactttttt
200101	attgctggca	gtcttggaat	aacagactgc	ctcctgatct	ttcagcatct	tctctgtagt
200161	tctcaggctt	actgggtact	gtgatttcaa	tctggaagac	tctccattgc	ctggatcttt
200221	gttagctaag	aaaccacctt	cttttcattt	cctaaacagt	tttaagattg	agaacaatta
200281	ttcttgctgt	ctgattttat	ctgctgaatc	ataaaaatct	tatccagggc	tcaaaataca
200341	tacacagtga	cagaacagag	agaaggaaca	gaactcccag	ccctttgaag	atcttgtatt
200401	ttgttcatgt	aggggtattg	tttgtttgtt	tttgaagttt	gtgcttggag	tactctagtc
200461	tacatgtttc	ttgaggaata	ttccaggaaa	tatcaaatac	atacgtatac	atatatatat
200521	gcaaaaaact	tttaaatatg	acttatgtaa	ataaaaagtg	taaattgtct	tataatataa
200581	aaatattcac	agcaagttgc	taaagtaccc	ccccccaaaa	aaaacctatt	gtatttagca
200641	caataactaa	aagaagtaca	actgcccctt	gaacaatgca	tgggttggaa	taccaccccc
200701	caactcagtc	aaaattttgt	gtgtaactgt	ttgttttttt	tctgagatgg	agtcttgctc
200761	tgtttccgag	gctggagtga	gctggtgcaa	ccttggctca	ctgcaacctc	cacctcccag
200821	gttSaagaaa	ttctcctgcc	tcagtctccc	aagtaattgg	gattacggta	tgtgccacca
200881	caaccagcta	agttttttgt	atttttagca	gagacagggt	ttcaccatgt	tggccaagct
200941	ggtcttgaac	tcctgacctc	aagtgaactg	ccccccctgg	gcctcttaaa	gtgctgggat
201001	tacagatgtg	Rgctaccatg	tccagccaaa	aatttgtgtg	taacttttga	ctcccacaaa
201061	atataactaa	tagccaactg	ttattggtaa	tagctttacc	aataacataa	acagttaaat
201121	aacatgtatt	ttgtatgtta	tatgtaatct	atactgtatt	cttacaataa	aatgaactag
201181	atgaaagaga	ataacattaa	gaaaatcata	aggaagagaa	aacatattca	caatttgtta
201241	aatgaaggcc	tttatcctca	gtgtcttcat	gttgagtagg	ctgaggagga	ggaagaggag
201301	gggttggtct	tgctgtctca	ggggtggcag	aggtagaaga	aaatcgatgt	ataagtggat
201361	ccacgtgtaa	gtggacccac	gtagttcaaa	tctgtgttgt	tgaaggatca	actgtaaaga
201421	gaacagggaa	cacaaccaca	acaacagctt	agccaaactg	aacatgccgc	cttgaaaagt
201481	cttgcagcaa	gctgtctccc	ccaatattct	acagtaacta	cctttgtcca	ttccgtttct
201541	gtttctaatt	tcttggcttt	tgtaattact	agtttcatta	cgctcagaaa	ggatggtcag
201601	gtagacagac	acctactaaa	agtaatgccc	caaactaaag	gggctaataa	atggtgaagt
201661	tctagaaggt	aatcattgtc	acttgttgag	catgaactgt	gctccagaca	ccagagcaag
201721	tgttgtatat	attttaactc	aattaatcct	caccatagag	catggtttgg	ggcgtcagac
201781	agagcttgca	tccatgtctt	agctttgcca	tttaactgct	tgcacgaatg	tagaaaagta
201841	acttaaatct	ctccagtctc	tgtttgttca	actgtcatca	ggtactgaag	agcatctgac
201901	aatttcctaa	ggtaactcta	caagagggaa	tgatgcatgt	tgaatttctg	catatgacat
201961	tataccatgt	atgaattctg	tttgccacca	gggcttacct	tcacctgcac	agtcatcttt
202021	ctaccacccc	aacatgccca	atttctttag	tcttttttgc	atggatctta	tttccaaggc
202081	attgaatcat	cttcactgtc	ctttctgaat	tatgctcgaa	ctctccataa	ttcattttag
202141	ttaaactcca	agcaaaacac	agctccctaa	taagggcctg	tctgacatcg	agtttaagag
202201	agggattagt	gtgtgcattt	tgcatgccat	atacctatac	tttaatccct	aacccatcgc
202261	tatgaaatag	cttgccctct	atttcSaatg	gagaagctga	ggcatgaaga	ttaatggtgt
202321	atactgacat	cacacaaatc	cagcaacaat	ttagcattct	ttgctctgat	ccaattttca
202381	ttaaacacca	atactctgtc	tctacttttt	ttcttgaaga	aacaagagca	acatgttcct
202441	tggaagatta	gaaggagaaa	gatgttggct	ttttgttttg	taagtacata	aatggtgttt
202501	gaatttttta	tataggtaag	gctagatcag	ccttgagcag	tttgctgtaa	gtgcaatgat
202561	tagaaccaca	ttgaagcaaa	acgaaagtac	aaatagtgtt	ttgtatgtta	aactattctg
202621	ttcaagtttt	tggtgaggac	tgggttttct	ggttcacttg	agacttttaa	acgactatta
202681	tcaaaataac	ttaaaacaga	atcaaaggaa	attaattcct	ttaccatgtt	attgaagacc
202741	atttcggttg	aaaaagaagg	acaacaaatg	aatagggcaa	aggattctga	gagaatccct
202801	gggtgtgcaa	ttcctgaatg	atagactggg	tctatcttct	gcattctgat	attgtctgtg
202861	ctgctgcatt	aatgtccatt	tatgtagtaa	atacttagta	aaaccctatg	cccacattag
202921	agtttatttt	ggaaggagga	agatgaaaac	aaaaggtatt	tcacttcatc	tacatctagg
202981	ttatcagcag	aggtcttggt	cttttcctgg	tcttataaac	attctataag	accattcctg
203041	gttttataaa	cattcttata	aacatataag	tatgaagaag	atattcccca	aaagagagtg
203101	atttcaccga	gacttcaaag	aaaagctcta	cacttggaca	tactttcttc	tgtgtctctg
203161	tcagtgtctt	attaatattg	ttcaccatca	tccaggtctc	agatagaggc	ttggcttttc
203221	cctttggaaa	tctggcttct	ggactttttt	tatggcattg	ctgtctggaa	ggctgagttc
203281	tgatggtgtt	ttctctatgt	gagtgaaagc	agcagtttct	tattttagaa	gaagcatttt
203341	tagggtttca	tcacatctgt	caaagacaaa	gccctagagg	tgaaatcctt	cctctacaag
203401	caagctcata	tctcctcatc	tctggtatct	caaacttccc	ttggaagata	ataaatggca
203461	ggtccttgag	aaacaggctt	gtcctcagag	aagcccaaag	tgctttaagg	gtcagtcaaa
203521	aggctgaaag	ttcagcattc	aactcctctg	agcactttgc	ccttgtgtcc	agccttgcag
203581	ccctggtgac	agttaacagc	cggattcttg	gtgacgtgga	aacttgatca	ccacttcagt
203641	gcacgggcca	tcaactatgt	gaccctgggg	tgaaagcctc	catgttatgt	tacctctccc
203701	cctcagccag	gccatccccc	aaaagcactg	cttttcaatt	tatatttata	ttgtctttcc
203761	ctccttcctg	ttctttcaca	cgaggcagct	gacaatggta	ataaatgtgg	tcgtactcaa
203821	ggatggggct	gtgacaggct	caataRggag	gggactgatS	tgttgctttg	gggttgaaag
203881	ctcagacttt	catgaaacaa	aaatattata	ttcagggtaa	tgatttatgg	ccttgactcc
203941	tgtttgattg	cagaccataa	atactagcaa	acggtactta	cggcatctct	agaggacatt
204001	aggaacatgc	tcaagtttat	tttatacagc	aattactgat	ggactataag	catggacatt
204061	atttgaaaga	cattattttc	tccaaaataa	gtctttgtag	atgataatgt	tcaacaatga
204121	ttttcataca	ctccaaccca	atccatgtga	ctcgaaagtg	ctcaaagaaa	tccaatgaca
204181	gatcaactag	ttgatgccaa	tcRatactct	gacaaggatc	tcatcttttt	tgttttttat
204241	cctgtaataa	gcttctcagc	ctcagatgca	tggcctatga	ctagcattat	cccttcaaaa
204301	tttagaaacc	acgaaatcat	ctggttgtaa	acttactgcc	tgggattgtc	ataggaacct
204361	tgttcaaatc	tctttgattt	cctcgtgtct	aatttgttta	gctgtaaagc	agggatacct
204421	tctccagggg	atagtatggg	ccttaatcac	atcatttcta	ttttcctgcc	ttttctgatg
204481	tagtctcatc	attactctca	ctctagagta	gatcctgagt	tctcttaccg	ccttgactat
204541	tccaaagtct	tgaagccatg	agaatgtgat	actattatcc	cattataact	gaagccggta
204601	ccagccagaa	tgtagaggag	tgacttatta	taagaatgtt	tcatttatat	tacaaaaaaa
204661	atttaaatcc	caagaggaat	ttatttatat	tccctgtatt	tagtgctcag	tttattaatt
204721	tatttaaagc	actaaattac	atttttYtaa	aacagatttg	atccttatgt	ggaaaagaaa
204781	aagacctctc	taaaactttc	tattgagtgg	taggagttgg	atccaaaaga	tgctatttga
204841	aatgctattg	aaggaaagtc	tcgctgcaga	taggagaatg	aatggcttag	gggctacttt
204901	acattcatta	ttacaattgg	tagccacttt	tccctcctta	tcttatttga	gagacttccc
204961	agaagataga	aaccaattaa	ctctttattt	tggcagtgat	catcctaggt	gttcttttaa
205021	cgggtattat	acttgctaaa	ttatagatga	gcttgctagt	aagacaaatg	ccattatctg
205081	agttatttat	tcatgggaca	tcgtctgcaa	catacccaca	ctagtttttc	gcaaagtttg
205141	gtattgatca	attgctttaa	tcagttgtac	caagggatgc	taaaagactc	agctatcaca
205201	gctttgaata	tcagcatctc	tctctgggtc	tctgccaggc	tgggagtgaa	aactgcagct
205261	attttcaaac	tcttaataac	aagaacgcta	agtagaagta	aatggctctt	tccatttaga
205321	tgggtgaatg	ttcatcatta	ctccgccttc	atacccatga	actcatcact	ttgacagtat
205381	catcatattt	ttgtttctgc	attttcttcc	tttggaatgt	tagctggaat	gtttgcaaac
205441	atctagcctc	ctggcctctt	ttaatgatac	ccacatatct	tttcagattt	tgctttcaaa
205501	gcagggaaca	aactctgctg	gttcctcaga	aacacatggc	caagatcctc	agtagataat
205561	cagcattctg	tctagaggca	attaaagatg	atatagttgg	ggctgtattt	ttatttatac
205621	tgtgtaatga	ggctccaaat	taaaaaagtt	atatcctaat	ctccattaat	gtaaggagtt
205681	gcagtcttgt	gagtgcagtg	gtccatatta	gatggcaaat	ttgtcatttt	tacactttcg
205741	ttcagtgcca	agattccgca	tttcctgagg	acaagtgctg	atgcaaatag	caggagctct
205801	acccacctct	cttttcgtcc	tactgtggaa	gtgggtttca	tttgagcaat	aagacatgac
205861	agacagcgca	tttgcgggca	attatgtcac	accttgggtg	gtatcagaaa	gcataaggtc
205921	aaaggatggg	ggctttaact	tcctaagaaa	tgcaataatg	accctgaaat	gcacagcttg
205981	ggtaccttat	tacaattgta	ggatggaata	cattaaaatg	aagaaaacaa	ggaacaaaga
206041	tgaaagtggg	acttggtcga	tgggggtatg	aaatcaatgt	caggcaatca	taagtctttg
206101	tatttgaatt	tctaaaagca	tttccaaatg	gttatccctt	cataaagctt	tagtactttc
206161	tcatgcacaa	tcagacacgg	attgtctaca	aagagcttct	aaccagttcc	tctacctttt
206221	tttaatgaag	ttggtaagaa	ttggaagaag	aaccatttct	ttttgtttga	gaagaaaact
206281	ttgtcaaggc	tggtggctgg	catctgcacc	agttttagac	aggccagWgg	taaggatggg
206341	acagtaccag	ttggagagga	tcagaaccct	gtggggtaag	taagcaccat	tgaatcactg
206401	ctgagaaatt	caaggcactc	tgtataaaga	caagacctgt	ggtaggctga	aaaatgcacc
206461	cctcacaaag	acatctgtat	cctagtccct	ggaacctatg	aatgttacct	tatatgacaa
206521	ttaaaaaaaa	taaataaagg	gtctttgcgg	attgattaag	taatgatctt	gagaaaggga
206581	gattgcactc	aatttccata	tgagccttaa	ataccatcat	atttccttgt	aagagagagc
206641	cagaggctgg	gtgcagtgac	tcagccctgt	aatcccagca	ctttgggagg	tggaggcaga
206701	agggttactt	gggcctagga	gttagagacc	agtctgggca	acatggcaaa	atcccatctc
206761	tacaaaaaat	acaaaaatta	gccagatgtg	gtggcatgcg	cctgttgcct	actcgggagg
206821	cagaggttgc	agtgagctga	gatcaggcca	ctgcactcta	gcctaggcga	cagagagaga
206881	Ytccatcttt	aaaaaaaaaa	aggaggcaga	ggaagattct	acacacagac	acacagagaa
206941	ggtgatgtga	ccacggaggc	agagactaga	cagatgcccc	cacaagccaa	ggaatgccag
207001	ccatctcgag	aagtgtgaag	aggcaaggaa	cagattctcc	cttagagctc	agtagggtgc
207061	atagccctgc	tgataccttg	gtttcaacac	agtgaaactg	ctttttggac	ttctggcctc
207121	cagaactatg	agagagaaag	tatttgttat	tttaagccac	ctagtttgtg	gtaatgtgtt
207181	gcagtgacca	ccggaaagta	acgagtccca	gtgggcttgg	ggctcccggt	gtctcaggcc
207241	ccacccctct	gggattgttc	ttctaggcta	ccatgtgggt	gtatttctac	atcatgcact
207301	gttttcaaag	aacccaaaag	tagacgatgt	cttgactacc	gttcagctgc	tttctcccYt
207361	gctatcattt	tctgtgggaa	ctatgagaca	ggaattaagc	ctcacagaca	cttcttttac
207421	aacYtcatgg	ttttcctcac	cctcatcctc	ccctgaccca	gagaagcaaa	atcctacttc
207481	tttttccaag	cctaattctc	tcagagaggc	ttctccttga	gcctctgagt	ttgcctccct
207541	cctcatagtt	catctcgtac	aaactatgac	tatcaatttt	aacccttctg	tgccatttgc
207601	cactgagaca	ccttatgtca	cagccatctc	cctggtgagg	ctctaacctc	taccaaggac
207661	agaaccttgt	cacctttcta	tcttccaagg	tgccaggacc	acatttccca	tcttgagatg
207721	taatgtttct	ttgaatagtg	atattgcttg	atggaaggat	acaagagctg	tccaaggaag
207781	gtgggctggt	cctgtgtttc	tgcttcggcc	tggagtctcc	tacatggtgg	gaaagtaaga
207841	gcttagacag	ctcaataggc	ccaaactgca	agacgtcatg	ccccaatact	tcttacagat
207901	gccaagtaag	agacgctgag	agatcaagag	acaggcagaa	gccgcaggga	tggagcaaag
207961	taggggtacg	ttaaagagaa	tcctaactgc	tccaagcaga	gttgagaacc	catagtttgt
208021	gtaactcaga	cagaccactt	aaagaaatgg	ggtcaaaaag	ccatgcatga	atatacctca
208081	gagatactgc	aagtgcagtc	tcaacctgtc	ccaataaagc	gagtcacgtg	aattttttgg
208141	gtttcccagt	gtgtacgaaa	tgtatgctta	cactgtactg	tggtctatta	agtgtgcatt
208201	atcattatgt	ctagaaaaac	aatgtacata	ccttaaagaa	aaaaatgctt	tattgttaaa
208261	aatgctaata	ataatctgag	ccttcaacaa	gtaattattt	gctagtggag	ggtcttgcct
208321	cgatgttgat	ggctgttgac	tgatcagact	ggtcattgct	gaagtttgag	atggctgtgg
208381	caagttctta	aaataagaca	atggtgaagt	ttgccacatc	gattggctct	ttcttccatg
208441	aaagatttcg	ccgtagcatg	agaagctgtt	ggatagtatt	ttacccacag	cagaactttg
208501	tttaacatta	gagtcaatcc	tctcatattc	tgtctctgct	tctcaactta	ctttatggaa
208561	tattctaaag	cctttgatgt	agtttcacca	atgctcactg	cgtcttcacc	aggagtacat
208621	accatctcaa	gaaaccactt	tctttgctca	tccataagaa	acaacttgac	atctattcaa
208681	atttgattat	gaaattccag	caattcaatg	acatcttctt	gctgcatttg	taattctagc
208741	tctcttgata	ttcccaccac	atctgcagtc	acttcctcta	ctcaagtctt	gaacccctca
208801	aagtcatcca	tgagggttag	aatcaccttc	ttcaaaactc	ctattaatat	tgatattttg
208861	atttcctcct	gtgaatcatg	aatgttctta	atggcatcta	gaatggtgaa	tcttttccag
208921	aaggtttcca	atttattttg	cccggattca	tcagaggaat	cactctctat	ggcagctata
208981	gccttacaaa	atggatttct	taaatagtaa	gacttgaaag	tcaaaattac	tctttgattc
209041	atgatctaca	gaatggatgt	tgtgttaccc	agaatgaaaa	caacgctcat	ctccttgtac
209101	atctcttcca	gagctcttga	gtgatcaggt	gtattgtcaa	tgagcaataa	cattttgaaa
209161	ggaatatttt	ttcctgagca	gcaggtctca	acagtgggct	taagatattt	aggaaaccat
209221	gctgtacaca	gatgtggtat	cattcatgct	ttgttgcttc	atttctagaa	cataggcaga
209281	gtcaatttag	cataatttta	agggtcttat	gattttcaga	atgatcaatg	agcactggct
209341	ttaactcaaa	gtcaccagct	tcattagccc	ctaacaagag	agtcagcctg	tcctttgaag
209401	ctttgaagcc	aggcactgac	ttttcatctY	gagccatgaa	agtcctcagt	ggcatcttcg
209461	aatagaaggc	tgttttgttt	acattgaaaa	tctgctgttt	agtgtagcca	ccttcatcaa
209521	tgatcttagc	tagatcttct	ggataacttg	ctgcagcttc	tccatcaaca	cttgctgctt
209581	tacttcacac	ttttaggtta	tggagatggc	ttctttcctt	aaacataaca	atccaacttc
209641	tgttagcttc	cagcttttct	tctgcagctt	cctgacctct	ctcagccttc	atggaattga
209701	aggagttgag	acattgctct	ggattaggct	ttggtttaca	ggaatgttgt	gactggtttg
209761	atcttctatc	cggacaaata	aaactttctc	catatcagca	ataagaccag	ttcactttct
209821	tatcctttgt	gggttcactg	gagtagcact	tttaattccc	ctcaataatt	ttcctttgcc
209881	ctcacaactt	ggctgtttgt	cccaagaggc	ctagctttca	gcctatctca	gctttccata
209941	tgccttcctc	accaagccga	atgatttctg	cttttgactt	caagtgagag	atgtgttact
210001	cttcctttca	cttgaacact	tagagaccac	tggaaggtta	ttatttggcc	taatttcagt
210061	attgttgtgt	cttctgaaat	agactctagg	agaggaagag	ggacagggaa	tggccagtta
210121	gtgaagcaat	cagaacaaac	agaacattta	tcaattaagt	gcaccatctt	agatgggcac
210181	agtttgtgga	accccaaaac	aattacaata	gtaactgaca	tcaaagatca	ttaatcacag
210241	agcaccataa	ccgatacaat	aataatgaaa	aagtttaaaa	tattgggaga	attgcaaaaa
210301	tgtgattcag	agatatgaag	tgagcacctg	ctgttggaaa	aatggtgccg	atcaatgtgc
210361	tgctcagtgc	agagttgtca	caaaccctca	attcgtaatt	ttttaatgca	acatttatga
210421	agcactataa	tgcaaagtac	gataaaacga	ggtacgcccg	tatctcagtg	aacacctagt
210481	gtgctgtgtt	gcatggatgg	gtggtcacat	gtccctgtct	ccttccacat	acatccactc
210541	atagtgaacc	cagaatactt	ctgggaccag	atgtgtgagg	atttttcccc	acacactaag
210601	caattcttca	gtggacacca	actaggtgtc	ctataattta	attcaatgtg	acactatcta
210661	cWtggaaatg	gtgtcagacc	ccacaggtta	agggctcagt	ctcacaatgc	ttccccaact
210721	ttagacacca	attgcaaggt	tagtacattg	tcgcctgtgc	ttctgactaa	ccgtctataa
210781	atcgggggtc	ctactactcc	ctccatgggt	ttaatttgct	agcatggctc	acagcactca
210841	gggaaacaca	cttacttatg	ttcaccagtt	tgttataaag	gatattacac	aggatacaga
210901	taaacagctg	aggaagagat	ggataccgtg	agttatgggg	gtgcacaact	tccaccccgt
210961	ctctggggct	ccaccctccc	agtacctccc	tgtattcagc	cactggaaac	tcaccaaatc
211021	ttgttgttca	agtttttgtg	aagcttgatt	tctatttgcc	ccccaccaac	ccaccagcta
211081	tcagtaggtg	gggctgacag	cKccaacctt	ctaatcctct	aatcaccttg	tctttctgtt
211141	gactggctcc	atacagagac	tatctagggg	Ygtcacccta	cgtaatctct	ttaccataaa
211201	ctcagaaagt	gatcaagtgg	cttcattata	aataacaaaa	atagtcctat	cactcagaag
211261	attccagggg	ttttaggaac	cccatgtcag	gaactgggaa	caaagaccaa	acatatttcg
211321	tataataccc	caatgaccat	taccaattgt	catagccatc	cRaggataca	gatgtatttc
211381	ataaatagtc	ctcttagtgt	ggcttaggga	taaaagtttg	tagacacctg	ctccaaactt
211441	tgaacattga	atttaaggtt	ggccaacctc	aggcactctg	gtgtgttatt	tataaataat
211501	aattcttcac	ccccctcgtc	ctcttatctg	tcatatgaag	agcccatggg	aacccttagc
211561	atcaggaatc	caactaattt	ccatttgatg	ggaggataca	gctggacttc	ctacccccat
211621	actgacattc	ctacttggca	gaggcgtgac	actaccctta	tttaggattc	aagaaacttg
211681	ctatttaaga	tttaggaaaa	attcctttct	tccagggaca	tttctcttga	acatgttttg
211741	tttcacatgt	aatttagtgg	tcacctaggg	gccaaagaaa	aacagagact	tttgtctatt
211801	tgtttatttc	ttaaggctat	catgaaagaa	aatccacgaa	taacttgagc	tgtcaatgga
211861	aacctttttt	taggactRga	tctctccttc	acatttaggt	agtgactggg	acatttatgg
211921	aagaaaaata	aataataata	ataattatta	tgatagctta	tcattgttca	gcctttgttc
211981	tgtgccaaag	atacagatga	tctcatctca	ttcttacaac	aaccatgtga	aattggtgct
212041	atgattaatt	tcagtttcac	agaaactgag	gccagtgagg	ttaagaaact	tcctaaaatc
212101	acacgcagct	agttagtgtt	gcaaaatctg	aacccaagca	atatgtctca	gtagcatgtg
212161	ccctctagta	tatatgtgta	tatatatgta	taggataaRa	ggattcatac	ttttgtagca
212221	ggtataaatc	ttagtctata	aactcagatg	ctttattttc	cataaatcaa	tgtaatatcc
212281	tctctaagcc	cttttcccac	tgggctggag	gaaataaaag	cttgaccatt	cttgaggttt
212341	ctctatcacc	atcttcagca	gatttgagca	gggcttgggg	atctgcctga	catgtcaaga
212401	tattggatag	actaggcYcc	tctgtttgat	gcctgttgag	aggcacattg	tccctggcca
212461	cgtgataatc	tctgttctgt	gggcttctgt	accaagcttg	ggaccaagag	tcttggggca
212521	cttccccagg	tgtatcacac	actcaccttc	cctgaggtcc	cgccatggcc	tcagggagca
212581	ggagcagatc	ctcatactct	tggactaggg	aatttttttt	tctttttttt	ttttttttga
212641	gacagtctca	ttctgttgcc	caggctggag	tgcagtggcg	caatctcgac	tcactgcaac
212701	ctccacctcc	caagttcaag	tgatcctcct	acctgagcct	ccagagtagc	tgagcctcca
212761	gagtagctgg	gagtacaggc	atgcgccacc	acgcctggct	aacttttgta	tttttaatag
212821	tgacggggat	tcaccatgtt	ggccaggcta	gtcttgaact	actgacctga	ggtgattcac
212881	ctgccttggc	ctcccaaatt	tctgggatta	caggcgtgag	ccactgtgtc	tggcctggac
212941	tagggaaatc	ttaattgctc	tgagaaaatg	caatctcctc	ttctttcctc	cctccctcct
213001	tctctgtctt	ttactctctc	ttctctcccc	gtgagagagc	tgcactttgc	actctttctt
213061	aagccaccga	tcttctcaat	ggactcagaa	ttttgacagc	ttttacagta	gggaacccta
213121	ccacagcacg	gaccttgata	cctctttgaa	caggcgaagg	tcaaggcaaa	acacagagtg
213181	aaagcttcaa	taaatatttc	aaaacacact	cttgccacat	cacctttcgc	ttatttttac
213241	aatatgctgc	acgcttactc	actctcacac	tcacaaacat	aactgcacaa	acatcatttc
213301	ccattctttt	gatgtttaaa	tactttcctt	ctcctatcag	atgaagttta	tattatctag
213361	gctttgtctc	tgacaattct	gatgttgttg	ttatggaaat	atgtcaagac	atttctttgt
213421	aaaaattccc	aatgaggctg	ggcacagtgg	ctcacacttg	taatcccacc	actttgggaa
213481	gctgaggtag	gaggatcact	tgagtccagg	aatcaagacc	agcctgggca	acattgtaag
213541	accccatctt	tacaaataat	agtaataata	attagctggg	catggagtgc	atgcctgtag
213601	tcccagctac	ccaggaggct	gaggtgggag	gatggcttga	gcttgggaag	ttgagggtgc
213661	agtgagctgt	gatcatgcca	ctgtgctcta	gcccaggtga	cacagtgaga	ttctatctaa
213721	aaaaaatttt	ccaataaact	ttacattata	gtgatgcccc	tgtggttgtg	ggcaatgtat
213781	aaatgatttg	actaattttt	tcccatatgt	caattcaacc	ctcaatattt	tccaaattta
213841	tcttagaatt	tatatttaaa	tttatgaatt	atcttgaaag	acctgattgt	ttggaatcta
213901	ccctcatcta	ttctacttat	ttgaatcttt	agaaagatta	ttaaaggaat	atttaagtgt
213961	gttgtttcat	ggaaattagg	aataccgagt	tataatgtaa	atatattcat	tcagaaactg
214021	gggtgggggt	cgggggggaa	gtcctcaggg	aagatacagt	attcactatt	gacgttggtt
214081	taatattgct	ttgtacagtt	gtttaatatg	tacgttgttt	gtattttatc	ttgtatatat
214141	ctctccacca	cacattaatc	cttggactgt	tagtacatac	agaacacatg	tcgggatgct
214201	ttctcagtgg	acctcatctt	cagggatcat	tttatttcca	cagtttagtg	cctccttact
214261	agaatagaga	actccataat	tttttctaaa	gattctatca	gtcttgatcc	aatgtgctag
214321	gtgataaatg	actgaacgct	ggccccggag	gggaagttag	caatgagtca	tgctgtctcc
214381	tagtaaccag	tcagtaaata	gcttccagca	aatattttaa	acctcaaagc	acacttacct
214441	ttggtattat	ccttagacag	actatcctca	tctatatctg	cactctcatc	tctctttcag
214501	aacttctaag	aaaggagaaa	aagtgggatc	gggtttgcat	atgacgtcac	ccccttgaaa
214561	acccacatga	aaacattcct	accccaggga	gtctgtctca	acaaaccttt	tccttgattt
214621	gtttctctgt	attttgcttg	ccctcaaatg	ttatgaagcc	atgtatactc	cacgtaattt
214681	tcatttgttt	gtttctagat	aggcccttct	atgtaactat	tcaatgagtc	catactgatg
214741	tgtgatttca	gagtttagca	tggaggtcag	cacacgatca	gaacagaaag	cgacactcaa
214801	gcaccctgct	cacacatccc	accaatgaca	ctgtttcaga	ctaattaatt	tacatgtgta
214861	aaggttattt	aaaacataaa	tcctccctaa	gtgagaggtg	ggaaagggga	gaattaagcc
214921	tattaatctt	gttcacctta	tccccacgta	agactgtttt	ctttagacat	ttagggtcag
214981	actctgtagc	atgggagtcc	ttattaggga	tatggaaaaa	aacacgagag	ttcgttttgg
215041	agcatggaac	atcaaaagat	gtgtctatgt	aaatgaatgc	aaaaggctac	tttagatgga
215101	cagagagcag	caagagagct	ccagacttta	gcaaaggagg	gatgcaaaga	gaaataacta
215161	ggaagggaag	atgagtagca	ggaaccaagg	tcactgtgaa	ccctcttagc	ctaactctaa
215221	ggtacggctg	caagtctctg	aattaaactg	tgagcctttt	aaagatgtga	tttcttctgt
215281	ttccttgttt	tcctctaaaa	ctctatacag	agtaagtgtg	cagcaaatgt	ttgctgaaca
215341	aatacacttc	cattttaggt	aaaaagtata	gatggtccct	agacagaaaa	taaagcacta
215401	agactgttYg	gcagggttat	aagaggtagc	gctgagattt	tgccaagaag	gcttttggct
215461	tttggctttt	ggaaaattag	tcccaaaagt	tagtgctctc	ttggataaac	tgaacccccg
215521	atccttcttc	agggcatctt	ttaaaattta	tttatttttt	atttttttca	gaccaagtct
215581	cactctgttg	cactcccagg	caggagtgca	atggggtgat	ctcggctcac	tgcaacctcc
215641	acctcccagg	ttcaagctat	tctcctgcct	cagcctccca	agaagctggg	attacagatg
215701	ctcgccacca	tgtctggcta	atttttgtat	ttttagtgga	gacagggttt	cactatgttg
215761	gccaggctgg	tctcgaacac	ctgtccttag	gtgatccacc	cacagggcat	cttttttttt
215881	tttatttttt	ttattatact	ctaagtttta	gggtacatgt	gcacattgtg	caggttagtt
215941	acatatgtat	acatgtgcca	tgctggtgcg	ctgcacccac	taatgtgtca	tctagcatta
216001	ggtatatctc	ccaatgctat	ccctcccccc	tcccccgacc	ccaccacagt	ccccagagtg
216061	tgatattccc	cttcctgtgt	ccatgtgatc	tcattgttca	attcccacct	atgagtgaga
216121	atatgcggtg	tttggttttt	tgttcttgcg	atagtttact	gagaatgatg	gtttccaatt
216181	tcatccatgt	ccctacaaag	gatatgaact	catcattttt	tatggctgca	tagtattcca
216241	tggtgtatat	gtgccacatt	ttcttaatcc	agtctatcat	tgttggacat	ttgggttggt
216301	tccaagtctt	tgctattgtg	aatagtgccg	caataaacat	acgtgtgcat	gtgtctttat
216361	agcagcatga	tttatagtcc	tttgggtata	tacccagtaa	tgggatggct	gggtcaaatg
216421	gtatttctag	ttctagatcc	ctgaggaatc	gccacactga	cttccacaat	ggttgaacta
216481	gttgacagtc	ccaccaacag	tgtaaaagtg	ttcctatttc	tccacatcct	ctccagcacc
216541	tgttgtttcc	tgacttttta	atgattgcca	tgctaactag	tgtgagatga	tatctcatag
216601	tggttttgat	ttgcatttct	ctgatggcca	gtgatgatga	gcatttcttc	atgtgttttt
216661	tggctgcata	aatgtcttct	tttgagaagt	gtctgttcac	gtccttcgcc	cactttttga
216721	tggggttgtt	tgtttttttc	ttgtaaattt	gtttgagttc	attgtagatt	ctggatatta
216781	gccctttgtc	agatgagtag	gttgcaaaaa	ttttctccca	tgttgtaggt	tgcctgttca
216841	ctctgatggt	agtttctttt	gctgtgcaga	agctctttag	tttaattaga	tcccatttgt
216901	caattttggc	ttttgttgcc	attgcttttg	gtgttttgga	catgaagtcc	ttgcccacgc
216961	ctatgtcctg	aatggtaatg	cctaggtttt	cttctagggt	ttttatggtt	ttaggtctaa
217021	cgtataaatc	tttaatccat	cttgaattga	ttttYgtata	aggtgtaagg	aagggatcca
217081	gtttcagctt	tctacatatg	gctagccagt	tttcccagca	ccatttatta	aatagggaat
217141	cctttcccca	ttgcttgttt	ttctcaggtt	tgtcaaagat	cagatagttg	tagatatgcg
217201	gcattatttc	tgagggctct	gttctgttcc	attgatctat	atctctgttt	tggtaccagt
217261	accatactgt	tttggttact	gtagccttgt	agtatagttt	gaagtcaggt	agtgtgatgc
217321	ctccagcttt	gttcttttgg	cttaggattg	acgtggcgat	gcgggctctt	ttttggttcc
217381	gtatgaactt	taaagtagtt	ttttccaatt	ctgtgaagaa	agtcattggt	agcttgatgg
217441	ggatggcatt	gaatctgtaa	attaccttgg	gcagtatggc	cattttcacg	atattgattc
217501	ttcctaccca	tgagcatgga	atgttcttcc	atttgtttgt	gtcctctttt	atttccttga
217561	gcagtggttt	gtagttctcc	ttgaagaggt	ccttcacatc	ccttgtaagt	tggattccta
217621	ggtattttat	tctctttgaa	gcaattgtga	atgggagttc	acccatgatt	tggctctctg
217681	tttgtctgtt	gttggtgtat	aagaatgctt	gtgatttttg	tacattgatt	ttgtatcctg
217741	agactttgct	gaagttgctt	atcagcttaa	ggagattttg	ggctgagacg	atggggtttt
217801	ctagataaac	agtcatgtcg	tctgcaaaca	gggacaattt	gacttcctct	tttcctaatt
217861	gaataccctt	tatttccttc	tcctgcctga	ttgccctggc	cagaacttcc	aacactatgt
217921	tgaataggag	tggtgagaga	gggcatccct	gtcttgtgcc	agttttcaaa	gggaatgctt
217981	ccagtttttg	cccattcagt	atgatattgg	ctgtgggttt	gtcatagata	gctcttatta
218041	ttttgaaata	cgtcccatca	atacctaatt	tattgagagt	ttttagcatg	aagggttgtt
218101	gaattttgtc	aaaggctttt	tctgcatcta	ttgagataat	catgtggttt	ttgtctttgg
218161	ctctgtttat	atgctggatt	acatttattg	atttgcatat	attgaaccag	ccttgcatcc
218221	cagggatgaa	gcccacttga	tcatggtgga	taagcttttt	gatgtgctgc	tggattcggt
218281	ttgccagtat	tttattgagg	atttttgcat	caatgttcat	caaggatatt	ggtctaaaat
218341	tctctttttt	ggttgtgtct	ctgcccggct	ttgRtatcag	aatgatgctg	gcctcataaa
218401	atgagttagg	gaggattccc	tctttttcta	ttgattggaa	tagtttcaga	aggaatggta
218461	ccagttcctc	cttgtacctc	tggtagaatt	cggctgtgaa	tccatctggt	cctggactct
218521	ttttggttgg	taaactattg	attattgcca	caatttcaga	gcctgttatt	ggtctattca
218581	gagattcaac	ttcttcctgg	tttagtcttg	ggagagtgta	tgtgtcgagg	aatgtatcca
218641	tttcttctag	attttctagt	ttatttgcgt	agaggtgttt	gtagtattct	ctgatggtag
218701	tttgtatttc	tgtgggatca	gtggtgatat	cccctttatc	attttttatt	gtgtctattt
218761	gattcttctc	tctttttttc	tttattagtc	ttgctagcgg	tctatcaatt	ttgttgatcc
218821	tttcaaaaaa	ccagctcctg	gattcattga	ttttttgaag	ggttttttgt	gtctctattt
218881	ccttcagttc	tgctctgatt	ttagttattt	cttgccttct	gctagctttt	gaatgtgttt
218941	gctcttgctt	ttctagttct	tttaattgtg	atgttagggt	gtcaattttg	gatctttcct
219001	gctttctctt	gtaggcattt	agtgctataa	atttccctct	acacactgct	ttgaatgcgt
219061	cccagagatt	ctggtatgtg	gtgtctttgt	tctcgttggt	ttcaaagaac	atctttattt
219121	ctgccttcat	ttcgttatgt	acccagtagt	cattcaggag	cagattgttc	agtttccatg
219181	tagttgagcg	gctttgagtg	agattcttaa	tcctgagttc	tagtttgatt	gcactgtggt
219241	ctgagagata	gtttgttata	atttctgttc	ttttacattt	gctgaggaga	gctttacttc
219301	caactatgtg	gtcaattttg	gaataggtgt	ggtgtggtgc	tgaaaaaaat	gtatattctg
219361	ttgatttggg	gtggagagtt	ctgtagatgt	ctattaggtc	tgcttggtgc	agatctgagt
219421	tcaattcctg	ggtatccttg	ttgactttct	gtctcgttga	tctgtctaat	gttgacagtg
219481	gggtgttaaa	gtctcccatt	attaatatgt	gggagtctaa	gtctctttgt	aggtcactga
219541	ggacttgctt	tatgaatctg	ggtgctcctg	tattgggtgc	ataaatattt	aggatagtta
219601	gctcctcttg	ttgaattgat	ccctttatca	ttatgtaatg	gccttctttg	tctcttttga
219661	tctttgttgg	tttaaagtct	gttttatcag	agactaggat	tgccacccct	gccttttttt
219721	gttttccatt	ggcttggtag	atcttcctcc	atccttttat	tttgagccta	tgtgtgtctc
219781	tgcacgtgag	atgggtttcc	tgaatacagc	acactgatgg	gtcttgactc	tttatccaac
219841	ttgccagtct	gtgtctttta	attgcagaat	ttagtccatt	tatatttaaa	gttaatattg
219901	ttatgtgtga	atttgatcct	gtcattatga	tgttagctgg	tgattttgct	cattagttga
219961	tgcagtttct	tcctagtctc	gatggtcttt	acattttggc	atgattttgc	agtggctggt
220021	accggttgtt	cctttccatg	tttagcgctt	ccttcaggag	ctcttttagg	gcagtcctgg
220081	tggtgacaaa	atctctcagc	atttgcttgt	ctataaagta	ttttatttct	ccttcactta
220141	tgaagcttag	tttggctgga	tatgaaattc	tgggttgaaa	attcttttct	ttaagaatgt
220201	tgaatattgg	cccccactct	cttctggctt	gtagggtttc	tgccgagaga	tccgctgtta
220261	gtctgatggg	ctttcctttg	agggtaaccc	gacctttctc	tctggctgcc	tttaacattt
220321	tttccttcat	ttcaactttg	gtgaatctga	caattatgtg	tcttggagtt	gctcttctcg
220381	aggagtatct	ttgtggcgtt	ctctgtattt	cctgaatctg	aacgttggcc	tgccttgcta
220441	gattggggaa	gttctcctgg	ataatatcct	gcagagtgtt	ttccaacttg	gttccattct
220501	ccacatcact	ttcaggtaca	ccaatcagac	gtagatttgg	tcttttcaca	tagtcccata
220561	tttcttggag	gctttgctca	tttcttttta	ttcttttttc	tctaaacttc	ccttctcgct
220621	tcatttcatt	catttcatct	tccattgctg	ataccctttc	ttccagttga	tcgcatcggc
220681	tcctgaggct	tctgcattct	tcacgtagtt	ctcgagcctt	ggttttcagc	tccatcagct
220741	cctttaagca	cttctctgta	ttggttattc	tagttataca	ttcttctaaa	tttttttcaa
220801	agttttcaac	ttctttgcct	ttggtttgaa	tgtcctcccg	tagctcagag	taatttgatc
220861	gtctgaagcc	ttcttctctc	agctcgtcaa	aatcattctc	catccagctt	tgttctgttg
220921	ctggtgagga	actgcgttcc	tttggaggag	gagaggcgct	ctgcgtttta	gagtttccag
220981	tYtttctgtt	ctgttttttc	cccatctttg	tggttttctc	tRcttttggt	ctttgatgat
221041	ggtgatgtac	agatgggttt	tcggtataga	tgtcctttct	ggttgttagt	tttccttcta
221101	acagacagga	ccctcagctg	caggtctgtt	ggaataccct	gccgtgtgag	gtgtcagtgt
221161	gcccctgctg	gggggtgcct	cccagttagg	ctgctcgggg	gtcaggggtc	agggacccac
221221	ttgaggaggc	agtctgcccg	ttctcagatc	tccagctgcg	tgctgggaga	accactgctc
221281	tcttcaaagc	tgtcagacag	ggacacttaa	gtctgcagag	gttactgctg	tctttttgtt
221341	tgtctgtgcc	ctgcccccaR	aggtggagcc	tacagaggca	ggcaggcctc	cttgagctgt
221401	ggtgggctcc	acccagttgg	agcttcccgg	ctgctttgtt	tacctaagca	agcgtgggca
221461	atggcgggcg	cccctccccc	agcctcgttg	ccgccttgca	gtttgatctc	agactgctgt
221521	gctagcagtc	agcgagactc	cgtgggcgta	ggaccctctg	agccaggtgt	ggaatatagt
221581	ctcgtggtgc	gccatttctt

Following is a NID2 genomic nucleotide sequence (SEQ ID NO: 2).

>14:50462485-50525750
rs3742536:32929
rs75305:34983
ctttttacct	gttgggcagt	aggggtagac	tgcagttatc	ccgtagaggt	gagatcgttg	60
ttctgggaga	tactcatcag	taaactggcc	actatgttta	tttactgata	caacaccatc	120
cctggtaaca	gaaaggaaga	gtgaattcag	ggacagtcat	ttactagata	aagaagtcag	180
tcagccacag	aaaatcagtt	gcaatagagg	aaaatttctg	gcagccttct	ctgtcccagg	240
gctggtgcta	aagccatact	gaagtttgaa	gaccattgct	ctaaatccat	tgctcatctc	300
tagctgcatg	ttagaatcac	atgatgagct	atcaaatcag	agttgtaggg	catggtgtaa	360
agggcttaga	ctttaatgtt	ccacagttcc	tcatttgaga	actagtctaa	atagtatttt	420
tcggtccctc	agacaatatg	tccacagtgt	caaaagccaa	cttaagccct	gtaatatagc	480
tcatggtatc	aagggtagtc	ttattctcta	aagaacatat	ttagattaat	atgctccctt	540
ttgagacatt	atccaatagc	tttgctactt	tttaagctat	atgtgagcaa	taccattcga	600
tttctgggtg	aagtaaaagg	atgatttcaa	aaacatgaaa	ggatgaaaaa	catccttgaa	660
ggatcttatc	tgccaatgag	gaggtgatga	aacaaaagcc	tcagagggct	taatgagtca	720
agtcaggtac	tgacttttgg	taaaacaagt	ggtgtgtcct	ctggaacagt	tggccttttc	780
aggcttgtcc	agaatttgtg	gggctcacct	cctccagtct	gtgtggtaga	agtgatctgc	840
atagcttacg	atgctgaagg	ggtacttgag	gttgttttga	atgacacgcc	gtccagttcc	900
atcaggtagt	gtacactcca	gttttttggt	tccttttaaa	acaaaggggg	aaaatgaggt	960
ccttcagctg	ctttgccaaa	aatgatagtg	acatagtgat	agtgacacag	tgatagaatg	1020
gggaaatagg	atattttact	tccattacag	tcatagatta	gcaactgtaa	aattacctgt	1080
cctattacta	gtctccagtt	tttagtagag	attcaaactt	tcaatccttt	tttggaagac	1140
aggattgcat	ttactgaaat	ctggtaagtt	tctgccaaag	tagggcatta	aacataatta	1200
tttttataat	ttgtgtgatt	tcaagcctta	gcttataaat	tataacatct	gggtaaatac	1260
ttgccctttg	taagctatgt	ctataattac	tgaggcaacc	ttttaaccaa	aatccttagt	1320
atttttaaaa	tattttctag	gtaggaggaa	aaaagtgact	aaaatggtaa	cataactcat	1380
atttcaatgt	aaaggaatca	gtcttaaaaa	tttttacaat	agctaaacca	ttcaagaatt	1440
tccaagtttc	acatttctca	tggagccgat	ttaaatttca	aatcctttta	agaaatgtaa	1500
cttgttttaa	acaactgggt	tataaaagtg	acctatgtac	attaggccct	tttattagat	1560
tacaaattca	agaacagtct	ttttcatatt	ctttagtata	gaactagaca	cacagcattt	1620
tttcagttgt	gctgataaaa	gcaaacaaat	gtaggttgct	aatacccatg	ttattactga	1680
aggaagctac	cctgctacaa	tgctttccaa	agaatgtcct	tagcattata	acagatgttt	1740
ataggtaagt	tatagtgacc	ctctccccgc	ataagaataa	cttcacttaa	gtttgtcaat	1800
tcaacaatgg	ctaattcttt	taactgttaa	aaatatgcca	ggcactcatg	gtcaggcaag	1860
cagtacaaac	ttactgcttg	atatatcctt	ccctccaccc	aaaccccaga	aagttcattt	1920
taagactcat	ttactagtac	ttaaatttac	tagtacttaa	aagtttacag	accaaagaaa	1980
ggagatctaa	gtgatgggat	ttcattttgt	agtaaaatct	gttagtgctc	acattcactg	2040
tgatgagagg	ttatctattt	gcattccatc	agtagtatta	cctgcatctg	cccagcagag	2100
cagtttagag	aaagggtcaa	aggttaagcc	attgggcaat	ccaatgtctg	tattgatcag	2160
aattcttctg	ttttctccat	ctaaagatga	cgtttcaatt	ttaggagctt	ctctattcca	2220
gtctgtccag	tacaagttgc	tgtaagttaa	aaatcaagat	tgtaaaagaa	tagccatgta	2280
gcctgtggta	ggcagcatct	aagcagcccc	cagtgatctc	catctcctca	tgtattatag	2340
ccttaagcaa	tccccttgag	tttgggctgc	attagtagtg	tcttgcttct	tctagtgcat	2400
agagtatagc	agaagtgata	ggctatcact	gccgatattc	ggtctcaaaa	aactggtttc	2460
tgccttaggg	gctctctctt	gctccctttg	agggaagctg	gatgccatgt	tgcaagctac	2520
cctgtaaagg	ggaacatgtg	ccaaggaact	gatgtccttg	agggctgttg	gccagagaca	2580
ttagtcttga	ctgtagccca	tgtgagcatg	cttgggctgt	gtcttccccg	agctgagcct	2640
tgtgatcact	gcagtttggc	cattacctga	ttgcagcctt	gtgagagact	ccatgcctga	2700
gggagctcgg	tgaagacaca	cttggattcc	tgactcacag	aaactgtgag	actaaatgtt	2760
atcttacact	gctgagggtt	tgggcaattt	cttacacagc	agtaggtaac	taatacacag	2820
ccatattcca	cttttacctg	tatcacaagg	ttttctgatt	attgtcacta	tgtgggagaa	2880
gtcattacta	agttactatc	agaatccctg	cctccaagat	accccttgac	tcaactgccc	2940
caaaaccctc	cgtttgttga	agtcttgaat	tggatcttgg	gttttagaat	agaaacaaat	3000
acagctgtta	ggaatggctt	cgatacaaac	tatggaactt	gaagagatgt	ggaccaggga	3060
tttgagaagg	aaactgttct	ttcttctgcc	aaaaatacaa	tttggtactt	gaaggggtac	3120
ctggcaccca	gggatggaaa	cattttaagt	taagcacttt	accttttaaa	tgccacgtta	3180
aaaatgaaat	atattcataa	cagatactaa	cgaggaaata	tggtcctatt	aagtggaaat	3240
aggttataag	gaaacaaaca	ggtttatcgt	tagagcagaa	ataatgttga	aagcactttt	3300
tataaaatac	tattttataa	aagctataga	agctttgaat	aaatcagttg	ggctacagag	3360
aacctcagtg	agaggagagg	aagaaaccat	aggtttcccc	tgttgcgaat	ttcatccctt	3420
atgcccaaca	gatgaagcag	agagaagctg	agagcaaaag	ctagaaagca	gtttccactt	3480
tgcgctaagg	tggaggtggc	cagagggtac	agcatgcata	tcattgcttc	atcgcttctg	3540
atcagtctcc	tccccaaaat	gatttaatat	catcaacaac	aataagtctg	aaacaagctc	3600
acacagatat	ttggtgtaaa	ttatttgggg	attgccagag	gaagaaagtt	gtaaaggtga	3660
aatctataga	aagcaaatga	gaaatatgca	ggaaggcttg	acaaccattc	tgttacgcag	3720
ttgaaggaga	tgtaattaca	tgtgttatat	tgcaacctgg	ttcaaggtgg	gttttctttt	3780
tattaaaaat	tcaagtcctt	tagcatttat	atttgctgtc	tggataagaa	agttctactt	3840
tcatatttaa	actcatggct	gtgatgtgga	tttcagctta	aaagtatgct	ttttccccag	3900
actccagaga	catggccaaa	gtttcattgc	ctacaagatg	gcagctctcc	ccagttttca	3960
ggtcaagcac	caagaaggaa	taaggggccg	ggcgcagtgg	ctcataccta	taatcccagc	4020
actttgggag	gccaaggcag	gtggatcacc	cagggtcagg	agttggagac	caaaatggcg	4080
aaaccctgtc	tcgactaaaa	atacaaaaat	tagctgggca	tggtggcaca	tgcctgtagt	4140
cccagctact	tgggaggctg	aggcaggaga	attgcttgaa	cccgggagat	ggaggttgta	4200
gtcagccgag	actgtgccac	tgcaccccag	cctcggcaac	aaagcaagac	cttgtctcaa	4260
aaaaaagaaa	aaaaaaagaa	aaaaggacct	tccaaatgtc	caaatgtcag	aaaggcaagc	4320
ctatgcaaag	agtttttaag	agggctatta	attcctgtta	agtcaactgg	aatagagaag	4380
gatacaggta	cttttcctgt	gtgtagaacc	caaagtttga	aaccaccttt	gaggcactgc	4440
actaagtatt	tcatagtcaa	aaagcactta	cctgaaaatt	aaagctgaag	gttttcttta	4500
ctgatttgaa	gggcatctgg	gaatttcatt	tcgtagaaac	tccacttaaa	catggcaaga	4560
gtttctcaag	atataaaaat	tctccctgat	tgtaacaagt	actgagacag	tgaacaaatc	4620
ctgtatgtca	catttgatga	ccttagcaat	tatacagaca	gggaaaatgt	ttatcttgat	4680
ttctgctaca	gcaacactga	agccagaggt	gtctgagctt	tggctaatgt	cacttgatgt	4740
aggtcagccc	tactgtgagc	gtcaaccctg	gtttctaaat	gtgctgctgg	aggaatccca	4800
cttcacttcc	agtttaagtg	tcagctgagg	cctcgcctga	tcatttgatt	cagagtagcc	4860
ctagttctca	caacactatc	tgaattttct	acatatcaca	tcacagacta	atattgttta	4920
taccagtctt	gtttcctcct	aataaaatat	aagtgccatg	aaagaacaga	ccttgtcttt	4980
tcctagaaca	ggtcctgaca	cctcttagat	cctcagtaaa	tctttgttac	atgaatgcat	5040
ttgagctttc	actctcttgt	tctgaccttc	cccacattgt	atttaaaacc	caagggcttc	5100
acatcaggat	ctacaggtaa	gagaagaatt	agggaagccc	agctgaccct	cggattggat	5160
ccacagcgat	ggcacgggga	ttcaccagat	ctgtgtagaa	gaggaccttg	cgctcagagc	5220
ctaccagttt	gatgacaacc	ggcatccaca	gtgccagagc	caggctgaat	aaacgaaggc	5580
gtcaccctga	attcttacca	tgaattcttt	taagaagtgc	gcacagtagg	aatcacctat	5640
ttcattccgt	atgtatgaag	gtgtttgctt	acagaggggg	ctagtcttat	acagctcaat	5700
aaaatgactt	gcctagaact	taacctcccc	taatggagaa	aaatcgaggg	gagacttcgg	5760
cgtaaagtag	acaagtgact	ttgtagaatc	aaatgaaatg	cagactgctg	agtgaagctg	5820
ctgacctgaa	ttcacgatcg	tctcaggctc	tgctcccagt	tccagaccag	cacggctgat	5880
tgtccgtcca	gcaacatctg	tccagtacac	catcctctcc	cggcagtcgt	aatcaattcc	5940
cacgattatg	gagccctttg	tgcatcaaat	catagaatta	gaagaattag	gttacatttc	6000
ccctttgttc	acactcagct	gccttgctca	tgcacagctg	cagtgagcaa	cactgcactg	6060
tgatcctgca	ggcaacagag	cagagtagct	ggacatgtgg	gcactcgggt	gaaatctagg	6120
ctcagccact	tagtagccat	gtggctttgg	gcatttaacc	tctatgcgtt	tgtctcattt	6180
gcaaaatgag	gccaatagtg	tacctgcctc	atatggttgc	tataaaaatt	aatactataa	6240
gtgcttgtaa	agtgtcctaa	tcagtaattg	gcatacagta	agcccttcaa	taggtgctat	6300
tatgactgat	gatttaaaaa	aaaaaaaaaa	tcagcccctt	cagtaattag	aggacatggc	6360
cttaagcaaa	ataagttttt	aatattttac	tgggtaaaaa	ctgaatcttt	tcccaatgtc	6420
atcagcactt	ttcccagagc	cttaataaaa	tttgccacta	tatgccaaca	aaatctactc	6480
tcccctcctc	tgtgaatgag	atctttcctc	tacctgaagt	acaatcacct	atactcctgc	6540
ccctgactct	taggaggcaa	gatgttggtt	atatcctgta	ctaaagaaag	tgtagtcagg	6600
cacagtgact	cacgcctgta	atccctgtcc	gttgggaggc	caaagcagga	ggattgcttg	6660
agcccaggag	ttcgagactg	agcaacatag	tgagaccccg	tctaaaaaac	aaaaaataaa	6720
tgaactgggc	atggtggcac	gcacctgtag	tcccagctac	tcaggagacc	gagttgggag	6780
gatcgcttga	gcccaggaag	tcaaggctgc	accaagccga	gatggtgcca	ctgcactgca	6840
gcctgggcaa	cacagagcta	caccctgtct	caaaagaagg	aaaaaatcta	atttattggg	6900
ttaaggaact	agggagtagt	ggttatccaa	cctctggcta	gtgaggtctc	tcctcctcat	6960
tgctaaataa	atgacaagtc	ttttaaaaaa	ataataaaaa	taaaaaaaat	gctgagtctg	7020
atatttttcc	tcaactccat	gcagaacttg	cttcattcag	tttccaatcc	aggctcctgc	7080
tctgagaagc	ccagcagatg	tgcaaagcca	acattcaggg	gttagctggc	tgtccctgag	7140
gtcatacaag	ttcctgcctt	gcctaacagc	ctcctggggc	ttggcttcac	ttacgccccc	7200
tgggagcgta	gtcagccaag	aaagattgta	caaaacggga	tttggcttca	gtggaaaaac	7260
aggcagctta	tatggggggc	gggcctaagg	tcaactacac	ttttatttga	aaattgaaaa	7320
gtcgtttgtc	ccaggcaaga	gtacacattc	aaatgagctt	ccattaaccc	gggaatcatg	7380
ggattcataa	acccatgtca	taacctcagg	ttagagaaaa	agtcccagtt	taagtaaatt	7440
tccttaaaat	gtgcaaataa	cccacgtccc	atttctttca	gttccactac	cactaccatc	7500
accaccctgt	cctggtcagg	ggcatgttca	gaaaggcaat	caagctctat	gacttgaata	7560
aaagagggtt	agcttaaagt	gatgtcaact	tcttagtctc	tacctcttcc	agagaaagtt	7620
ttacaaaaca	atgtgagagt	tttcttgggg	gaggggacag	gacccaacaa	actcgaatct	7680
taaaaagaac	acatctcttc	ctaaacactg	gctgcctcta	agcttttctg	gaaccaaata	7740
agtgtcgttc	attaacagaa	gtaaatgtaa	acttgaatgc	cgtactattc	tttctcaggg	7800
atgagcaagt	gcctggagtg	tgaagttcaa	caatggaatc	agatgatttt	ccactgtgtc	7860
gatgccattc	gagacagcca	cccttttttt	tcctccattt	ttgagaaaac	ccgctcccca	7920
aaatggggtg	ccttgcatta	gggaggctgc	tggctcagga	agcatcaaac	atcccctggg	7980
gaaggctcca	tccactcctc	tcccagcatc	acacactcct	caagttttca	tctatggagt	8040
cagggaaggt	taggaaagaa	gtgggtcaaa	gggacagaac	caaagtgaaa	gggaagggct	8100
gcaacggtga	gacagtcatt	aactgacttc	cacttggagt	ccccaacaaa	ccgcagagat	8160
cacaccttgt	gactagttgt	cctgtcactt	tgatttccag	gatttccatg	gagatgttat	8220
gacatacaac	cctggggact	tagggtaaga	gtcggtaaga	tttcccttgg	atcaccatac	8280
agcctccatg	tgctgacaac	tctaaagttc	cctttccata	ttatctgaaa	ctccatgaac	8340
gaaccagaga	gcacagcctt	ggtcagtgac	aggtgactcc	cagcaagaga	gagccctggt	8400
cctatggtgg	tggcatcggg	cccatgccga	tgggctgcag	ctcagaaacc	ctccaggact	8460
tccctgcacc	agtccacctc	actgcaacag	ggcctgtgag	gtggctccca	ctgggaaagc	8520
cacgcagccc	tgccccctac	aggagaaatc	cactttacat	gcagagacag	cagggtctta	8580
gctgcatcct	tctgaagcct	ggtgccattg	aggggtaagt	agccaatctg	ctggccctga	8640
gtatagagca	ggaaggtgcc	cacagatgga	ggggtcacat	ctggccgggg	cgtgggccgg	8700
accatgggtg	gagcgacggt	gggtatacct	gtgggagaga	gggtgggaga	gcaggaaggg	8760
gaacaagggc	aggcagggag	atgggaagaa	aagttacttt	accacatacc	agagcctcca	8880
ctaatttcta	gggttttttt	aaggatcaat	tatgtaaatc	tgccatttac	tagggaagaa	8940
gacagcaaaa	cacttccctc	agaacaaagc	agaacagatt	tttttttcaa	gagaaaaaaa	9000
aaacagagcc	agcattgtgt	cagcttcctt	ttaggactcc	agagtgacac	gtgtcccctg	9060
tcaccctggg	ctggggaggg	ggagtaactg	cctgctgaac	cgagttgcag	atgttccaat	9120
tatggaagct	gctaatgaca	aaaaccagac	accaaacgca	aattgggatc	ttgtgtggca	9180
cagattataa	atcaacatag	cacatagtga	cttctttcat	tagacctggt	gaccccacat	9240
gtccccccac	ttcaccacag	caggcaccat	ccctagcaaa	ggccttagat	acagctgagg	9300
ggagcggggg	cggccaggtg	cttacacgca	ggggtggtgc	ctggctggga	gcgggtgccc	9360
tgcacctctc	tgccatcttt	gtccacacac	cagcagaagt	cgctctttcc	gtggcactgc	9420
agggggatga	agtggcccag	gtcatcgcac	tggggcacgt	actggtcatc	ccggggggtg	9480
ccaccgtagt	gctccagcag	gttttccctc	cagcgctcac	agatggtcgg	gggcctctgg	9540
gtgggctctg	agcagatggg	gaagagggaa	gaagaaaaac	ctttgattgt	gagtcaagga	9600
cagaatgcaa	aatgtagctc	aagaccccat	gggtggcctc	ctggccttcc	ttctcctact	9660
gtccaggtct	cagccaagcc	cgtggacacc	aaacttggga	agcaaatgtg	ttctaagtac	9720
ttctccacca	tgggaatcag	aaatagatca	tgtgatgctt	ctttcttgcc	aggagggtct	9780
gtcatcaagg	cccagccaca	tcaagaaaga	acaagaggag	gtaagatcag	cagtgcagct	9480
cactcagcct	gggaaggggc	atgatctcct	tctggccagg	agaggcccac	aaggcccatc	9900
ctgcctgtac	ctcgggcgcc	tctgctgaca	gagcacttgt	gcaggtgatc	cttggggact	9960
cagtagccga	ggtgatgctt	aaagccaatt	tgtattcatt	ccccacttgc	ttcaagcttc	10020
aagctcgaag	ctgctgagga	gagggccatc	ttgcgactgg	ccagtgtgtg	tcttagaaag	10080
tattactgaa	agcccagcgc	cacggtgccc	tctgtctacc	cactggaaaa	ctacatggag	10140
taaaggtaaa	actgagtgga	attagtagta	aagcatagca	gaggtggtgg	caaacagctt	10200
aaaaatggtt	cttccacagc	ccagtttcca	gaattgcttt	agccaccctg	cgcctgggat	10260
tatctcaaag	ctgaatcttt	tcctgcaggc	tctagcttcc	tgccgtgttg	ccctttcccc	10320
ccctttctcc	agcatcctct	cctcttgtcc	cctccctcac	agctcactcc	atggttgaag	10380
tcctgctggc	tttggttgca	aagcagtttc	ctcccaggct	gcttccacag	tgccattgag	10440
gctttgtcca	aaatacaggt	tgttctgaga	agactctgct	gcagaaggtt	attgagataa	10500
cttgttcatt	tatgttagga	ctacccaaag	gaacttaaac	aagaggaggt	gcttctcctt	10560
cctttttaat	tcctgcaact	taaagcacat	ggtctgcaga	atcacatagc	caataaccct	10620
acttgctacc	accatttaga	tgtataatag	aaatcagaaa	ctaatagaaa	ctgagcccct	10680
gccttcacca	tcaaaccagc	tgctcccctg	gtctttccca	tatgagtaaa	tggcacctcc	10740
atttttccac	tgctcagacc	taattatcct	tgaccctcct	ttctctcacc	atccacattt	10800
gatatgtcaa	aaactctttt	taggggtaac	ttcagaatcc	acttagaata	tctttacttc	10860
tcactactgc	accccctcac	cctggtcaaa	aagcctcatc	ctctccctgc	aatttctgca	10920
acagccttcc	cactggtttt	cctgcttcca	cccttctatg	ccctcactct	ctccaaaacc	10980
agtgtaaatt	caattagcag	cagccagaat	ggcccatttt	aaacataaag	gcatttcatg	11040
tcactccgtt	caaaaccctc	cagtgactct	aaagaacaaa	gctgggagca	ttatgatcat	11100
gttccagcac	ctacaattcc	tcttggaaca	caaaagactg	cgaatgaagt	tgtcagagct	11160
caaacccaac	tagctctagc	tcaactgcac	gactcaccag	aattggggga	agcgaatgcc	11220
gttaagttgt	cactgtagct	catgacccat	gggagacaaa	gctcttttta	agaccccgtg	11280
gagaaggtaa	gactctgact	tcttcagcca	aatgtgtctc	aaggaacaca	gagagggaaa	11340
tgctacttcc	tcaaacactg	caggatttcc	tggagaagtt	cccaattcca	cccctgctcc	11400
acattcagaa	ctccaaggat	ccatttttgc	tttaagggac	caccctgtgc	tatgtgtctg	11460
cattccaaac	aaagagacat	gcctaactcc	tgggaaatgg	gtgtcccaaa	tcactcatac	11520
atgggcatcc	ctttcattcg	ttactatttg	ctacttttca	acccaaccat	gaatttcttt	11580
ctcttgtgct	tctggttggc	aagggtttaa	gtattttgaa	attgtgggca	cagagcgtcc	11640
ttaccctccc	tcaagctgac	cccatcaaac	atgagaccag	tcagagatag	catggggggc	11700
caaaccagcg	ccgagagagt	gtgggcagga	aaaagtccgc	acaagagaac	acgaccctat	11760
tttcgtcatt	cacttctcag	tctcttggtt	cccccccctt	taaaatcttg	gttccccctt	11820
taaaatcatt	gtccttaaca	catgcctgtc	ttaataaatt	taatcgaatt	ctgaaccatt	11880
ccccaaaggc	acctcccaac	catttgattt	cttcaaatcc	cagatggagt	tagaaccaag	11940
acattttcaa	agagaaggca	tgagggaaat	agaatttctc	tgtacctttt	ttggaccttt	12000
aaaatctttt	cctaaaaata	gaaacaaaga	gcgactatgg	atcaaaccat	taccaatttt	12060
tacctatctg	agaaccgcca	agacctgacc	tttttttaaa	aaaacaaaaa	aaacagagtc	12120
tcactctgtt	gccaggctgg	agggcagtgg	catgatcttg	gcctactgca	acctctgcct	12180
cctgggttca	agtgattctc	ctgcctcagc	ctcccgagga	gctgggacta	caggtgcgtg	12240
ccaccacgcc	cagctaattt	ttgtattttt	agtagagacg	gggtttcact	atgttggcca	12300
ggatggtctc	aatctcttga	cctcgtgatc	cacccgcctc	ggcctcccaa	agtgctggga	12360
ttacaggcat	gagccaccat	acccgggcaa	cagttaacac	cattaaaagg	gaaaaaaact	12420
attggtaatt	ctccagttct	tcttactttc	acacattaaa	agccaagact	agtatttatg	12480
gaacccttct	caatagtaaa	aatggatctt	tggatagcaa	gctgtgtcgg	aatcattttg	12540
gctaaaacgg	tatcaagcca	atcctatgct	cttcattaaa	taaagttctt	ctgtaatgat	12600
taaagaaaca	agttttacct	atccctgaat	aattcaacaa	ggaacagaaa	gttgccttat	12660
ctgcctgctg	ttggaatcga	ctgtgagcac	ttgatcacca	tgccccaccc	agctggggaa	12720
tgctctagat	ggtagcaggc	atgttctcag	gttgtatggg	ctaacagaaa	ccagatgtct	12780
gtgcctcctc	tgagatgttg	ggctgggtta	cagagggctg	ggattgtcag	tttagagaaa	12840
actaactggc	tccactagca	ggtgttattt	ttctaatttt	tcctattgat	actaacagag	12900
cgttcatact	gtttcctgcc	attcagaagg	cagaggtaag	tgagatagtt	acataggaaa	12960
gcatttttcc	ttctggtcaa	aacgccagtc	tggccagatc	ttctaactgt	cagatctccc	13020
taagctgctc	tataacaggt	ctagggtagt	gttctcagtc	tgacctacat	acacaatctc	13080
aactttcagt	ttgtactgga	caagggtcta	agaggcaaat	gtgtaacaga	tcatatgtgt	13140
catgtattgc	atatctctat	gtccttatga	cacaaacatg	catatttgta	cgcactatta	13200
ttcaagtctt	ctcaggagga	aagaggctat	gaaggatggt	gactggcccc	gtgcctgcgt	13260
ggtctgggca	ggaattatga	tctacctacc	accagtgcca	ttctgcttct	tgagccccag	13320
gcctaagctc	acctggtgat	ggtccacagt	gaggcggggt	ggagccaggt	ggagtctggg	13380
taccaggaac	ttcatgacca	tcagggtcca	cgcaccagca	gaaaccagtg	ctgccatgac	13440
actgtagggg	caggaagttg	ccctgctcgt	cgcattgggg	gatgtggaac	cgggccccag	13500
ggtaggcata	ctgggcctgg	gcatggcgct	gctgttgttc	acagggtgtc	aggcttgagg	13560
tggagtcttc	caggatcaag	gcagaggaag	acacaaaaga	gaaatagaag	gcattgcaac	13620
ccatccactt	caccagccca	cagcgtggca	tggaaaagcg	ctgggatttt	ggagcccgag	13680
attcttattt	tataatacct	tgccactatt	tacctcattt	ctctccagtt	cttctagttc	13740
atcctatagg	tccctagctg	gctctaagtg	taaagcagcc	cggcccctcc	ctattgtcat	13800
ctggggaaaa	tgagggatag	cggtggcatc	tgcccaacat	cccaagagac	tctggagaaa	13860
acaagccaaa	gctcattcat	gccctgaggc	ccacaggtta	agtctgagaa	gctgcaagcc	13920
aacggcactc	accactcacg	agactgcacc	aagctagcca	agctcctcta	acacggtcgc	13980
cacgggctta	accctggcta	ccggcgcata	aggctctgct	taataagctt	gatctcaaca	14040
cttcatccaa	attgcactca	tcaaggtcaa	gcagatcact	agggcagtta	accagagggg	14100
ctatgaggta	ggactatggg	tgggtcgtct	cccgcaggcc	tccagaaatg	ttacgaatca	14160
gtgaactatc	agtaaactag	gcagcaggag	gtaaccaagg	aaaaaaatcc	acagcttgga	14220
aaatccacca	aggctccaga	ccaggctaaa	tcaagagtgg	gctgtcatag	aaaaatatcc	14280
ttgaaggagc	taagagattc	atgtgcctaa	tctggccctc	tgaaacttac	caggtatgca	14340
ctgaaatcca	tccccataat	atccgggttg	acaacggcag	gagaaggaac	caggagtatt	14400
gtagcaggta	gctgcagggt	gacatctgtt	ttctgagcat	tcatctacat	ctgcagaggt	14460
cagaaacaga	agaaagaagc	aaagaacact	atgacttcac	tcacacaatc	tgtgcgactg	14520
catgggcttt	ggatatgtgg	atcaacaccc	agtgaggtgt	cagcttcaga	agacctttga	14580
gcatgagcag	aaaaatgctg	acacctaaag	gtaagcttaa	tagaaaggaa	gaaaaaaaat	14640
caaggaacat	gtgagttaac	acactagact	aaacgtgttc	agtgtagaaa	tcaaatgggt	14700
agtcgctcac	agaaaaaaac	aacacatctt	acagcatgtt	tcattgacag	tgaattcaag	14760
gaagttatta	cctttgaact	aacctttaga	ctataagtca	ttaacttcct	ttcagcaatg	14820
ctgcaataaa	gacaaatata	tccaacaatg	gttttttttt	ctttcgttgt	tggcaccatc	14880
tccctgtaac	attcgtctgt	agatgcaaag	gagccagatg	aggcccaaat	atttttcagc	14940
taagaagcac	attctgtctt	gactaattag	aatcttacta	tctagaacca	cacccccatt	15000
aaccaggtat	tttctttact	ttccactttt	agaagaaata	agaaaaaaat	attatctagg	15060
gttttgaaat	aatacttaca	aaatggaaat	ctaaatttgc	caggcatatc	agtacaaaca	15120
attcaggccc	ctacactctc	cacatagcac	catgaggatt	aattttcacc	atcatatttc	15180
tcaaaacaac	aaaatcctga	cacttcaaac	aaaagccaac	ttacattcct	tttatttaat	15240
gaaatccgca	tatgccgaca	atagcaagtc	acccacccct	cccatcccca	gcagaaaaaa	15300
agcagctctg	agaattgaat	ggttaaaact	aacgcccaag	ggatgagata	agctacttta	15360
agagacagga	agtctttcag	agtaaaagga	ggataaacaa	agggtgtagg	tccgattaag	15420
gcttggctga	aaataaaaca	aagcagtagt	tccatccata	gtaataacca	agtttcttta	15480
aaatgtgtga	atagaaaaaa	aaaaaatgtg	ggatggtgtg	atcagtgtga	aacctagaaa	15540
atgagaatgt	gttgcatcaa	tacggtgcag	cccatggtag	agacacatca	gcatgggaag	15600
acagatattt	gaagccctaa	atttgatgtg	aatgggttgg	gaacagggct	agctcctcac	15660
ccaggctccc	atgacccaca	tggaacctct	tctagagtta	cctgcaccac	cctttgtcca	15720
gaccacactg	tcactgggtc	atcctctaat	aactaatgtg	ctttctcgaa	taccattaag	15780
tacacacact	gggcattaag	cttaggtgtt	ctgttcccta	gagaggaatc	tcttatgtta	15840
taattagaag	gtaagtattc	tgcttatctt	ctgtctctgg	ggagtttagt	cagcatatat	15900
catttcctag	gagtcctccc	ccaaaaattc	tgaactcaat	gcaacccata	gagtctccac	15960
ccaggtgagt	ggttggcctc	cctggatacc	atcatttcgc	ctataaaggc	aagaaagcag	16020
atatcaattc	atctgcaagg	gtagaaacaa	accagattgg	ctcctcagtt	accctgaaat	16080
caaccaatgt	tgtcataatt	atccctgagc	ttggctctgc	ctcttcaaca	ggacaattca	16140
aatgcccagc	tgggcaaaac	tggtgaccat	ccaatacctt	ggacctggaa	taggctgtaa	16200
aactggctgt	aaaactaaac	ctgtaaaaat	taacattcag	ccgaatgcag	gaaattaaag	16260
ctattcacaa	tacgcatgct	aaaagtactt	ctaatggtaa	caggaacccc	aagcaatgac	16320
aggaagcagg	aattcctgag	acacagggcc	tatttctgga	gcccatggat	cagtttctta	16380
ttgttacttt	tgaactcaag	agagagggga	ttccccagag	ctaccaaata	aatcaacggt	16440
gtgcttagaa	ccttcagcct	aagaattctg	actcaatctg	aaagaccagc	cttcctcccc	16500
acagatactg	ttggcatcat	caaagatact	aaagttctgg	gtagacagaa	actattagaa	16560
atgaccaaca	aggaggagaa	agtccccaaa	gagactgaag	atatcacaag	tgagaaattc	16620
ctgccccaaa	gattgagact	ccctgaattc	gcagtcctga	ctcctccttg	gagggcctct	16680
cacaccatga	tagagactag	agtcccggga	cctgggcatg	cacaggacat	cagatgtcaa	16740
gagagaaaac	atggaaagac	tttcagcccc	ctggcaaggg	aggaacttta	ttggagaagg	16800
agaaggaggc	cactgcttat	gcttagtcat	tactagcagg	ggcctgtagg	gactgctata	16860
aagacaaaaa	cgttcaagaa	gtcgtagagc	ccctttatca	ctcaggtaat	gagaggtagc	16920
ttaatctcag	tgcaatccta	cactctatta	agctagtaaa	gaacctgttt	ggaaaatgtg	16980
ttaaaaatcc	ttcgagttca	tgctttcgtg	cttcaacatc	cttctcactg	cccaagtact	17040
gagcaaaacc	agcaggaact	gttggatgat	aaacctaacc	cctggcctcg	agttccccca	17100
ggctcccgcc	ccttcaccac	tgcccacttg	cctttgagcc	cagtgaaatt	tcttggcatc	17160
aattaacctc	aaacccatcc	cagatcccaa	taaaggattc	aacccacagg	tcccactctc	17220
tctctactgc	acaatctggt	caattgggca	ccctgctgat	tgtacccctg	tatggcatgt	17280
ggtgaaccca	ctccagacct	gtaagtgtaa	taaactactt	cctttcaagc	ttcatccttg	17340
cctcctccta	taaccacact	gattttacca	taccataccc	aacatctacc	tacattcttg	17400
gaacaggaaa	cctggccagg	cacataatgg	agatcatgct	ttcgttatca	aagaagagag	17460
aagctaggcc	gggtgtggtg	gctgacgcct	gtaatcccag	cactttggga	ggctgagggg	17520
ggtagatcga	ttgagctcag	gagtttgaga	caagcctggg	caacatgatg	aaaccccatc	17580
tctacaagag	ataccaaaat	tagctgggca	tgctacttgg	gggggctgag	atgtgaggat	17640
cacttgagcc	tggaaggctg	aggctgcagt	gagctgtaat	cacaccactg	ccctccagcc	17700
tgggtgataa	agtaagaccc	tgcctaaaaa	aataaataaa	taaataaaaa	ttaaaaaaaa	17760
ataagaaaag	aaaaaacgcc	aggaaaccca	agaaagaata	atgtcagtat	cttccctcag	17820
gcccctgagt	aatgatggct	ctgggtaatg	ggccatctgt	aacccagctt	cctcaactca	17880
cacttgctcc	tcctgggaag	gtcccaactc	aagacaatct	gcttttgcac	ctggccaagt	17940
cacaacaatc	caaaaggaca	aacatgtctg	agaaatatcc	agctcacacc	aacacaagtt	18000
tgaaatcact	ccagattgag	ggaagctgca	gaggatttaa	ctctacttgg	ataaaagcct	18060
cctggctagt	gactcagacc	agactgagaa	cccaaatcca	agtgcagcct	ctccagggag	18120
ccggtttttt	taacaaacta	tggctggaga	aaaactccca	caccccctta	ttgttagttt	18180
gatggagtaa	aagagcatgt	gctttaacaa	tgcatagcac	ccacaaaata	cagcctctgt	18240
tctttggtca	ctgagacaca	tgtaccctat	ggaatgcctt	taaatatgca	cacatacaca	18300
tatatttcaa	tatttattct	tcaagttact	ttcatgatta	gcctagcctg	atttatgcat	18360
gggtctttag	gaaaatgacc	attcattctc	tactactcca	caatctgaaa	gtttagaaga	18420
caactacatg	gtaagtggct	gtggtaggca	gcctctaaga	tggcccccaa	cagtccctac	18480
ctagtggtat	tcatggtctt	gtgtaatccc	caccctttca	gtaacttgct	tttaattaat	18540
aaagcaacat	tgaagggatg	tcatttttgt	gattatgact	tccatcttgc	tagcagactt	18600
tctctggcat	taataaaata	agctgtagtg	ttagagaggc	ccaagtggca	agaaactgaa	18660
ggcagccaac	aaccagcaag	gaaccaaggc	tttcaatcca	atggtcctca	aagaaccgaa	18720
tcctgcccat	aaccacgagt	ggatctttcc	ccagttaagc	cttcagatga	gaccactgac	18780
ccaccagaca	ctttgactgt	ggccttgtga	gagatcctaa	agcacaggac	ccagctgagc	18840
cattcccagg	tccctggacc	actgatatta	aatgtctatt	gcttgaagct	gctacatttt	18900
agggtaattt	attatacagc	aatagataac	caatacactg	ggggaagcac	ctgatgggtt	18960
tggcatattt	ttagtttgta	ggctttggaa	agaatcctaa	aagcagagaa	ccagaaataa	19020
aatagggaca	attgaaaatg	acaaaaatag	ggcaaattaa	aaaatgacaa	tacttaaatt	19080
cccaatatgg	aaaagtagtc	aatttcagag	ccctaacatg	accccagaag	gtaatcaaag	19140
tcttgcagga	caagtagaag	aaaaaaggag	ggagagaatc	attgtagaag	tgatcaaagc	19200
atgcagcatc	taatctaaat	taatattctg	attaacactc	atcatatcta	ggctgaaatt	19260
aatttcaact	tctttgcttt	aaaccagaga	gctaaggaac	taaatatttt	aaaagcacca	19320
tctctgctga	tctgagcagc	cagatgttta	aataaattct	acagacaaga	tttttctcag	19380
tggattcaca	tttcttagag	ctggtactag	ggttaaacca	aacaaacgat	gtgttccaca	19440
cgaaggaaaa	gcatcattcc	cactgtcagg	ctttggcacc	tcaccctgaa	ctccatacct	19500
gtagagggta	tctgtaaaga	gtgtatctat	tatagatata	ctcaatgttt	tctcaccagt	19560
atatctatga	cagatggagc	tcctggctgg	ttaagtggga	caaacatctg	tgaattacaa	19620
atctacctca	ttctaattgg	gaaatactct	ttatctagag	ctaggggtgt	ttattcaaga	19680
ggtccatagt	cttcttacat	tactgggcct	aataccaaga	cacacaggaa	tcccaactga	19740
gggttaccat	ctgtattagt	caatttcctg	ttgtttataa	tagaatatct	gaaactgagt	19800
catttctaaa	ggaaaggaat	ttatttctta	tagttctaaa	ggctgagaag	tctaaggtca	19860
agggttgaaa	tctggtgatg	gccttcctgc	tggttgggac	tctcagtaga	gggctgaggt	19920
ggtgcaggac	atcacatggt	gagggggctg	agtgtgctaa	catgttattt	taggcaggcc	19980
tcccttctta	tcaagcctct	agttccattc	ccaagataac	ccattaatcc	attgataggg	20040
gcagagctct	catgatccaa	tcacctttta	aaggccctac	ctctcaatac	tgccacagtg	20100
gaatgtaagt	ttcaacatga	gttttgaaga	agacgaatat	tcaagccata	gcttcaactt	20160
tcaataccac	caccaaaagt	atctatttag	tgaaagaaaa	aaataaaagg	gctgaactga	20220
gccacggctt	tgggttagtt	cagcataaat	tgttcgagaa	aaccatgcag	cagagcttct	20280
gtacagcaca	agtggaaaga	gtaagaatga	ggctcagaaa	ccaccatgtg	cacttgcccc	20340
atccagagag	aagtggaggg	ctgagctgct	gtcacagtga	cctttgttct	gtcagtaaca	20400
catggcctca	gcctgctgtc	cactcagccc	atcctgctga	aaccaaaggg	gaaaaaggaa	20460
tgggagaagg	atgagaatca	aacatctggt	gaggaggagg	gaggcccgtg	ctattcggat	20520
ctggtataaa	gctcccagga	attgcaaagc	tgttcttagc	acatcagctc	ggtgggcctg	20580
ggcggatgga	ggcagatgca	cacagcaaca	ccaggagcag	gggaaagtct	gccttttaag	20640
gttcatgttc	cccagcaggc	cctttcccat	tctaaacacg	tttcccacca	ttctctcatc	20700
cccagtgtgt	cgttttaccc	taactgtgtg	tgtgtgactc	acgtgaaact	gagtttcaat	20760
ctgatcacat	accacagggt	atgtttggaa	aaccttttgt	gatttaagat	ttatttaatg	20820
atttctattt	taaagtactc	ctaatcctag	tttcatggac	atttatactc	agagagttat	20880
gtcgagcctt	taaataacaa	cctcacacat	tctttctaag	ttaaattcca	atggctagcc	20940
ttgcaaatgg	tttggtgctt	ttataaaata	ctgcattaag	tcttaaagat	agatttctgg	21000
gagaaaagtt	ttgatatgtg	tctttttata	tatgtggagt	tctctctttt	gaaagaggag	21060
aaaaattaga	aattacatat	gtgtttagag	attgcttaaa	atatcactta	aagcagaaga	21120
gcacaaccat	aagtgttgaa	ttaaggtgga	gaccgcctaa	caggaaggta	tgcaactttc	21180
cctaaattcc	tccagcctgc	gctggctcca	aggaaccaag	gttagaagct	cccgagtgct	21240
acaggaacgt	ctccgccaag	gaagccatat	atgctcgccc	atctagtcca	gaggaaatca	21300
cccttggctc	ccctttctaa	ctcaaaggac	gcttttttct	cactattttg	gcagccacaa	21360
ggctgttaga	gtcaaaggaa	gtcctttgtc	ttttctggga	gagctccatc	tatgtgggga	21420
tgtgcatcca	aagcaacttt	ccagtcattg	aggctgacct	gcagttactc	accagtgcac	21480
tggtgcccat	cgccggcata	accaggcagg	caggcacagc	tgaacgtgct	gcctccatgg	21540
tgaacacacc	gggcctgccc	agcaggagca	caggtatgac	tgccatcctc	acaggggttg	21600
gcaggtgggg	tgatcactga	aaagagaaga	agataagggc	atccagagtt	taggcctgca	21660
aaggatgagc	ctcactcctc	atggcatgat	ccacagacca	acagcaacag	accagggaat	21720
gcaggttctc	agaccctacc	caaggtccag	tgattcagaa	tctggatttt	aataagattc	21780
ctagatggtt	tgtatgctat	taaagttcaa	gtactggtat	gaatttgctg	ttaaaatact	21840
aagcacaaaa	acccatcacc	taagcagtcc	tcaattaaag	tttataacat	tccagagcaa	21900
ttgctacaca	cacacacaca	cacacacaca	cacacacacg	cagtttctcc	tgtcactttt	21960
accctcatcc	cactgaatta	aagagtgcat	tttctttctt	tttttttttt	ttttgagatg	22020
gagtctcact	ctgtcgccag	gctggagtac	agtggcgtga	tctcggctca	ctgcaacctc	22080
caactccctg	gttcaagtga	ttctcctgcc	tcagcctcct	gagtagctgg	gattacaggc	22140
gtgagccacc	atgcctggct	aaagagtgca	ttttctttac	tctcatccat	ctttatcaat	22200
gggatgaatt	gggatagttc	ttttgatcca	tttttaggtc	tgtagtattt	tctggaaata	22260
cagaagaggt	aatttgttac	agaaggagct	ctttagccag	tcaagtagga	catgcatcag	22320
tgaattataa	atccatctct	tctaatttga	aaaatacttt	aggctctatc	taaagagctg	22380
gaggtgttta	ctagtgaagt	tcatcatctt	gttacatgac	tgggccagaa	atcccaactg	22440
aggtgggcat	ccttcaataa	ctcaacacca	aaaatatcta	tttagggaaa	aacagtgaaa	22500
ataaacaggg	ctgaaactga	gccatagctt	tgagagattt	tgttgttttt	ttttttgttt	22560
ttttgagaca	gagtctcact	ctattaccta	ggctggaatg	cactagcatg	ctgtcagttc	22620
actgcaacct	ctgcctcctg	cgctcaagca	atcctcctat	ctcagcctcg	tgagtagctg	22680
ggactacagg	cgtgtgccac	cacacctggc	taatgttttg	tattgtttgt	agagacgggg	22740
ttttgctatg	ttgcccaggc	tggtctcgaa	cttctgaact	caagcgatcc	acctgcctca	22800
gccttccaaa	gcgatgatta	caggcgtgag	ccaccacatc	cagccagctt	tgggttattt	22860
tgatgtaaac	tgtcttctta	agaaaaccat	atagcagagc	ctctgaatag	cagaagtcaa	22920
aacactgaca	gattaaagag	caagattaaa	gagcaccatt	ttggccacac	aggaaaatga	22980
ttttggaact	cacagatgca	agtatgccgg	tcatctgcaa	actcataacc	actccggcac	23040
tcacacctgt	agcttccagg	caagttgata	catacagagt	tggggccaca	gcgatgaaag	23100
ccagttgcac	attcattttc	atctaagaag	aaatgagaag	agaaaaattc	tgcttaattc	23160
aagggtccca	gaagtggagg	gtctaaaaac	tcaatgtttt	ctcactagta	tgatgcttca	23220
atgggacaaa	tggttggcag	atgtagaatt	tttaaaaatc	agatatgaat	gcatgttgca	23280
gataatcaga	aatagtaaaa	atttcatgcc	attcaagtaa	acaccacagg	aagataaatt	23340
tttaagtgaa	tattctaaga	attctttaac	tgttttaaaa	agaatggata	cttggaagaa	23400
aaccaacaat	tttttttaat	atcaagaaat	ttctaccgtt	gccttttggg	gatataagac	23460
acacaatgtc	tgtctaaaat	ttaaagaaaa	tcagaaaatg	tgctttttgg	taagtctaag	23520
aactacttac	tacaaaagct	caaaattaca	aaacttaact	caaaacatcc	aggaactgca	23580
acagatgttt	tcttttcaca	gccccggtgc	aaaatccact	ccactccaaa	ccatcttttc	23640
aaacataaac	agctatgctt	taatttttaa	ataactatat	tcagattaac	agctgctaaa	23700
atcattgaca	atggaggttg	taaaggtgac	agatacttgt	cttctacaga	cataaggctg	23760
gggagggcag	aggaaaaaca	agggctacaa	gaaggagaca	cgagaacatg	gctcttaccc	23820
acacagttcc	gtccatctcc	ctggtaccca	gatgcgcact	cacaggtgta	atctacacct	23880
gtccctggat	ggcaccgtgc	tgttgtgtca	cacatgtggc	tcccatcata	gcaaggattc	23940
cccggagtgg	ggtctgaatc	ctctgcatga	gtagagggga	aataaaagca	caatctggct	24000
attggtaagc	aaatgtcacg	gagatagagg	agtcctcgga	actgactgca	tgtctgtgtt	24060
ttgtgacaca	ccggaagacc	ttactaaatt	atccatatct	gaagctaggg	tggattttct	24120
gcacttcagt	tttaaactcc	agcatggctt	cctattgcct	accctataga	caactagtac	24180
ctttacttgc	tttcagtagg	tttgcatcca	gggaataaaa	acgcccaaaa	catctgttta	24240
aaagtgcttt	tgctctatta	tttcctgtga	ttcttgggat	gattctatgt	ggtgagttgt	24300
tttccccatt	atgtgtaatt	ttcacagata	aggaaatcaa	gtgagacatg	ggaaaaattg	24360
cccaagctca	caaagtcagg	aagtggcaca	gcaaagactc	agactccaac	ttcctggttc	24420
taaatctgtt	gatctcttac	taaaattccc	aatttttata	ggtaaatcca	attaatttta	24480
aaaatcttgt	tttttaaaga	tttctaagac	taaacaggaa	tgactttccc	agtatttact	24540
cttcaggagt	agccttacca	aggatccatc	tactcactag	gtagcgatta	cttaacgact	24600
gaaatctccc	ctgagagaaa	tctatttggc	tgagcatggt	ggctcatgcc	tgtaatccca	24660
gcactttggg	aggctgaggt	aggaggatag	tttgaagcca	ggagttcaag	accagcctgg	24720
gcaatatgcc	aagaccttat	ctcgagagaa	agaaaagaaa	gaaagaaaga	aagagaaaga	24780
aagaaagaaa	agaaagaaag	aaagaaagaa	agaaagaaag	aaagaaagaa	agaaagaaag	24840
gaaggaaggg	aaagaaagaa	agaaagaaag	aaagaaagag	aaagaaaaag	aaagaaagag	24900
aaagaaagag	aaagaaaaag	agaaagaaag	aaagaaaaag	aaaagaaaga	aaaggaaaag	24960
aaaagaaaga	aaattagccg	agcatggtgg	cccatgcttg	tagtcccagc	tactccagag	25020
ggtgaggcag	gaggatgact	tgagcccagg	agcttaagct	tgcagtgagc	catgattgtg	25080
ccactgcact	ccagcctagg	tgacagaaca	ggaccatgtc	ttaaaatata	tatatttatt	25140
tctacataat	agtcaatgct	cattgagcat	ttatgtgtga	ggcattgttc	taaacagata	25200
ggaggatgcc	tgattacatc	cttctaacta	catggtgagg	aaaatactat	ctccacttct	25260
gctgcatcac	agagaggcca	aataacctgc	ccagggttac	acagtcagaa	gaggtggatg	25320
gagctggaat	aaaagtctag	cagtctggtt	ccatagctca	tgctttccac	cgctttgctg	25380
caaccctcac	tgaaggaact	tcatgaagtt	atctagtcta	agccaatggc	acagaggtat	25440
tggaaggagt	gtcagatgct	caggtagaat	gaatctatca	actctggcac	ttctgtgtac	25500
ttctgagtct	gccatgtaaa	atggaaatag	gaacatgtac	atctgccaat	cctgctaaag	25560
aaaattaaga	aaacccaaca	gaacatattt	gaaaggcaat	tccccattgg	caggtctacc	25620
cagtctctac	tgactgcact	ccttctgcct	tctcagtggg	gccactgttc	atcattattt	25680
gaggttctag	ctcaacctca	gtccctagaa	ttaactctaa	tcttagactc	aaaagatttc	25740
cagagcccca	gctaagcctg	tcaggttcta	cattgagcca	tctctgctac	aaagggagat	25800
ccatctaagt	tgtaataact	caggcttctg	cctcatactt	ctgtgcctga	ggccctgtct	25860
tgatagccag	cttagcatcc	tctgagtccc	atcctgctca	ccagttctca	ctactcacag	25920
acaccagcat	catggcatct	gtaggcagac	actggcagta	ccacccattt	taccaccttc	25980
tcctggattc	tctatcattt	cactctttct	gacccgtgtc	tcccacccca	ctttgtacag	26040
aatcttctat	taaaatggag	aaataacaac	aggagagaat	caggttcttg	tcttatactg	26100
agccttcaat	gaggacatga	ccctgttgtt	ctccattgta	acagatgctg	actcaggaac	26160
ctggtctata	ctctcaagtt	aacttggcaa	ccacaacccc	actgctatgg	ggggagactt	26220
gcccagagtg	actcctaatc	tagatcccaa	gtgctgactg	ctgcagctga	cctcatagac	26280
tggactcgct	cccaagtcct	tcagggtgtc	tggcattctc	ccccgtgcct	gccctactgc	26340
ccacgttatg	gctcttccag	tgccctgtca	tagcctgctg	tgagctggga	tgccttggct	26400
gagacagcct	tgttttctgg	taaactcttt	ccatcccact	ttataagaaa	caccacagtg	26460
cattcttgta	gtggaatatt	cccgtattat	tgattcccgt	attattggct	gaaaataagg	26520
agggctatgg	gtttatcctc	agttcaccac	aatgttgtcg	gctggagtaa	cagaatcttt	26580
gccaaaacaa	aggaccaata	aataattcca	gcacttttta	aacctgatga	actatgtcag	26640
cataagccta	gctccctgaa	gcatgcagac	atccttggag	gtccgttcct	ctggatctct	26700
tggctgacag	gaaagaggca	ccgcactggg	gttgtggttg	ccgagttaac	ttgagcctag	26760
accaggttcc	tgagtcagtc	ctcaataggt	tataactaag	gacaaggtca	tgtcttcatc	26820
cattaggacc	caatgtaaga	caagaacgtg	atcatctccc	atcatttctc	cattttagga	26880
agattctgta	caaaatgcct	ggcatacccc	accaaagcag	gaagtaattg	tcaacatgtt	26940
ttgatttata	aatactaatg	cttagccttc	ttattcagta	ctttccagca	tcaaaatttc	27000
accatggcac	attccagcaa	agattagtgt	gttcacatgg	acatcaagag	cttaccaccc	27060
tgctaggcat	taaaagaaaa	aaaaaaaatc	tcagctcaaa	agttgacttg	caaacttgga	27120
caggatatat	tatcctacct	aaaattgaga	agaaagtgtc	cctaattact	caatactgat	27180
ttaaaatgta	tgtcactgac	aggattagtt	ccataatttg	caatccccag	tgcaaaatga	27240
aaatgtggag	cccatggttc	aaagcaaagc	gttaaaccaa	gcatggggct	cttctgagca	27300
cagggcccca	ttcactgaac	ttggcttccc	aaaacatttt	taaaatacat	ttctaaaacc	27360
atttcacgac	tcattctcta	tgacttgtaa	gcttttctcc	tattatagta	agtaaagaac	27420
acagtatcct	tcttaagaca	ttttctattt	cgccctcacc	ctcttaaact	gcctgactct	27480
cttaacagag	gatctggaac	taatttactc	atttaatcaa	ggggaagagc	ggttttcctt	27540
aaaggaacag	tcccttcagc	ttcactgcac	agccctctgc	ccagagcctc	ctcaactcgc	27600
caaaaggacc	cgtgaagtgg	aaggacagga	agcatttttg	gatcgtgttt	tatgacccca	27660
caaaacaacc	aaccaaccaa	caacaacaaa	aaacagctga	ctcacactta	aagcttaaag	27720
ctcaaacaac	tggtgggggg	tggcactgct	ggttgagaag	tcaccgaggg	acagaggctc	27780
caattactca	ctgggaaaga	caccccagtt	ctgcatcctc	gccctgggaa	gtcgcaccac	27840
acccacatca	ggtgtggaca	gctgcgctgt	ttcacatgaa	ttccaacaac	tatcgttccc	27900
tctggaaaaa	ctgagcagtt	cttaggaaga	tactgctgtg	taccaagagg	ggaaagaaaa	27960
aacttttggg	tgtttctttt	ttgtttttct	ttttttccct	cctattcagg	tagaatgaac	28020
agtactgctg	tgtgtggatg	aagtagggtt	caaacacaaa	gggtttaaaa	gacacacatt	28080
gcctctttca	aagtttggtc	taaattatga	ggcagtcatg	aggccactgt	ggaacagcag	28140
agccatgagg	ggtaagggtg	tgcgtactgg	agccagtgcc	tgagtttgag	tcccagctca	28200
cccaggtcac	ttactatgac	caggcaaatt	acttcatttc	tatacctcag	tctcatcatc	28260
tgtaaaatgg	gataacaaat	aaccccaccc	ccaccccacc	attgggtaga	ggtcattgtg	28320
gggattaaat	gagttaattc	atgtaaggtg	cttagaacag	tacttggcac	caagtaaacc	28380
atcctttgat	attattattt	gactggggtg	ggagggaaaa	tcataaaatt	ctaaagaaaa	28440
caagcaactt	ggtacctgcc	agtttgcttt	ctctgatcct	ttcttactct	catttggtat	28500
gtctctagga	aaaatatacc	cagagacaca	tctttttcct	aaatggttcc	agaatctgaa	28560
tgggactcca	tagcctggga	aatttcacta	acagttgctt	ttacagatca	gatgcctaca	28620
cccaacacag	ggctgacctg	gacatttaaa	ggtaaagacc	attctcccca	gtaggtttaa	28680
atctctcttt	gagaaatcta	ctacagcaat	ctttcccttt	ctaatttaca	tgttcctcta	28740
aaatcaactc	acattttcat	gtgttcattt	gctaccttac	aatccaatat	ctgggcacct	28800
aatgcctaca	ttcccaacca	agtttcttaa	aaccaaagca	cctcgggatt	ctcattacaa	28860
gtcactttcg	catcctagaa	aagagtctag	tccttgtacc	ttaatcttgt	catattgctg	28920
aagcaacact	tctttattga	gcctgctgag	gcttaaggag	ccctcagctc	caataacaaa	28980
gcacagaacc	gcgtatcact	tacagattca	cctcactgag	gagctaactc	tgggctcaac	29040
agtttcaata	cagtggctga	attgaggaag	atggtttttt	tctcctggtg	tggctcttac	29100
attctagggg	aaaacatgac	ctggttttca	gaattaaaat	gtccccttga	tctgacaaag	29160
ccacttccca	tctgtagagt	tccctgactt	cacaagctca	tcctctggct	tgcttgaaac	29200
attttttaat	aattaagacc	ttgcttttta	ggatggtttt	acatttagag	aaaaatggag	29280
cagaaagtac	gagctcccat	atccccccac	ccaaaatgtg	cagtttcccc	tattatcaac	29340
attgtgcatt	agtgtggtgc	atttgttatc	cccaatcaat	actgacacat	tattaactaa	29400
tgcccatagt	ctgcagtagg	gctcactctt	ggtgttggac	agttctatag	actgacaaac	29460
gcataatggc	ctataaccaa	cattacaata	tcatacagaa	tagtttcact	gccctaaaaa	29520
tcccatgttc	cacctatgca	tccttctcct	tcttcctcct	gaaccactgg	caaccactga	29580
tctttttact	gtctctatag	tgtaaccttt	tccagaatgt	catggttaga	atgattctgt	29640
atgtagcctt	ttcagactag	ctgctttcac	agagcaacat	gcttttaagt	ttcctgcatg	29700
tctttctgtg	acatgatatg	cctagaacat	tttaaaatca	gtcttcacag	gtgaggctaa	29760
tggtcattaa	aatttgagaa	ccactgctta	ctttgagacg	gggtcttgtt	atgtggccaa	29820
ctctggcctc	aaactcctgg	gctcaggtga	tcctcccacc	tcagcctcca	gagtagctgg	29880
gattacaggt	gtaagccact	gtacccgatg	agaatggttt	tagagttttg	tttctactac	29940
tatttgcttc	catttatttt	tattttttga	gacggagtct	cactctgttg	cacaggctgg	30000
aatgcgatgg	cacaatcttg	gctcactgca	acctccgcct	cctgggttca	atcagttctc	30060
ctgtttcagc	ctcctgagta	gctgggacta	cagacacatg	ccaccacacc	tggctaaatt	30120
tttttgtgta	tatatatata	tatatatata	tgttttattt	tgtagagaca	gggtttcacc	30180
atgttggcca	ggctggtctt	gaactcctga	cctcaggtga	tccacccacc	tcagcctccc	30240
aaagtgctgg	gattacaggc	ataagccagt	atgcctggcc	ttcagttgag	aagtaattca	30300
cataccatac	aattcatccg	tttaaagtac	ataattaaac	aatttcgtct	attcagtgtt	30360
atccaaccgt	caccacaatc	aatttcagaa	cattttcatc	acccccaaaa	ttaaccctgt	30420
accctttagc	tattaacgcc	ctatgctctc	attatctctt	agccctgggc	aaccatgaat	30480
atgctttcta	tgtatgtgga	tttgcctatt	ttggatattt	cacataattg	taaccattca	30540
gtatgctgtc	ctttgtcact	gactaccttc	acttaaggtt	ttcagagttc	atccatgttg	30600
cagcatgtat	ccgtacttca	ttccttttta	tggttgaata	atattccagt	atatgaatat	30660
attttttggt	gtccatcaac	tgatgggcat	gtatgttgct	tccacctttt	ggctattatg	30720
aatactgcca	ctatgaatat	acacgaataa	gtttttgtgg	ggatctatgt	tttcatttct	30780
tttgggtata	tagaaaggag	tagaattgct	ccattaaatg	gtaactttgt	gtttcacttt	30840
gagaaaccac	tattttgttt	ttcacagtag	ccacatcatt	ttataatcac	accagcaacg	30900
tatgagggtt	ccgaattttc	catgttctcg	ccaacacttg	ttattacccg	ttttttgatt	30960
atactcgacc	acatgatgta	aagtagtatc	tcattgtggt	tttgatttgc	atttccctga	31020
tgactaatga	tgctgagcat	ctttacacat	gcccattggg	tatctgtata	tctttttgga	31080
gagaggtcct	tgcagagctt	ttgcccatct	tttagttagc	ttgttttttt	attgagttgt	31140
aagatacttc	gtatactcta	gaacaaatat	cacatgattt	aaaatactgt	ctcccattct	31200
atggctgtgt	tttcactttg	ttaataatgt	cctctgaagc	acaaactgtt	aaaattttga	31260
tgacacccag	tttattttgc	tgttgcttgt	gcttttagtg	tcgtacctaa	gaaaccatta	31320
gcaaattcaa	agtcacaaaa	atttacccat	atgttttctt	ctaaaagttt	taactcttac	31380
acttaggtct	gttggcccat	tttgagttgg	atatgctgtg	aggtaaaagg	ttcaacttca	31440
ttcttttgta	tgtggtcact	cagtggtccc	agcaccatag	ttaacaatag	tttaaaagac	31500
tattctttct	ccattgaatt	gttttggcac	tgtgtttttt	gttttgtttt	gtcttttaac	31560
catcagaatt	ctattattat	tatactttaa	gttttagggt	acatgtttac	aacgtgcagg	31620
tttgttacat	atgtgtacat	gtgccatgtt	ggtgagctgc	acccattaac	tcgtcattta	31680
gcattaggta	tatctcctaa	tgctatccct	ccccactccc	ggcactgttg	ttgaaaaagc	31740
aattgacttt	taatgtgagt	atttctgggt	tcccacttct	gttcctttga	tctttacatg	31800
tatccttacg	ccaggaccac	actgtcttga	ttactctaga	tttcgagttt	gagaaataca	31860
agtctgactt	tattcttttc	caagattgtt	ttggctattc	tgtgttcttt	gaatttccat	31920
ataaattcta	gaatcagctt	gccaatttct	tcaaagagcc	agctgagatt	ctgataggga	31980
ttatgttgaa	ttaatagatc	aatttgggaa	gtattcacat	cttaacagta	ttaagtcttc	32040
caatccatga	atgtggaaca	tcttcccatt	taactgggtc	ttaaattttt	ttccaaaaat	32100
gttttgtggg	atgcaatgta	caagtactgc	acttcttttt	aaaaatttat	ctctttttga	32160
aacaatttct	taatctttag	tttgctcatt	gctactatag	agaaatacaa	tttggtgtac	32220
tgatcttgca	tatcttataa	cattgcgaac	ttgttcttta	gttctaatag	tgttttagtg	32280
aattcctgag	attttctaca	caaaatgtca	tctgagacta	attttacttt	gtccttttcc	32340
aatttagatg	gcttttattt	tgtgttcttg	cctaatcacc	ctggctagaa	attctagtac	32400
tgaattgaat	aaaagtggca	acagcagaca	tccttgtctt	gttcctaagc	ttcagggaaa	32460
agcatccagt	ctttcaccat	taagtataat	gttctgggaa	tcatggaggg	ggaggttata	32520
catcaagttc	tatgatgttt	ggtttttcca	gatactagct	ctttgctcca	ccttagtttt	32580
ggatgaaatt	cttctcatct	gttttagcta	aaatgtcact	ttcttgggga	catcttttct	32640
gaatcttcaa	actagactca	cagtgccctg	ctctcatcac	acttgtaaca	aatacttgtc	32700
agcatcactc	tccctcctaa	ttccagtctg	ccttgttcac	aggtatattc	ctgattggca	32760
cgcacagttg	ggtattgcta	taaaccagct	tcacatacta	tgctctattt	cctgactttg	32820
gcagggacac	tgttccctgc	cctaaaactc	ttttctgcct	ctgtttccaa	ctcaagggca	32880
aggatctgct	ctattcatcc	ttatacctag	cacataacac	agcatggcRc	taggtaaccc	32940
ttagtaacct	ctgtgaatca	ttctaactct	acttaaaagg	atgtcatttt	tacccaacaa	33000
caaaaaagga	aaccttacct	ttgaccgggc	caatttgatt	ggtcacagca	aatctaagca	33060
ctctttcttc	gtcattatac	aaggcaaaga	cccggtccac	gttcagctgc	tgggtggtgg	33120
ggaaggacgg	gtgtctgggg	gcgtgcctgc	acacctggta	agtgatgttc	tggtggatgc	33180
ggtaggacca	tgtttggttg	attgcaccaa	aagtcagaga	gtagtctctg	gaacttgtag	33240
aggtcacagc	tgcaacaaac	acagtggtaa	ttttttaaaa	atattaaata	cagagatttt	33300
catgtgaggt	ggatttttct	gcagtttttt	tcatctaatt	cttggagtgt	gttcccttgg	33360
gaacctcctg	agtttatatg	aaaaaatgtg	taaggaaatc	ccaaaaacct	gagtggatgc	33420
aaagccacag	tgctgagagg	gagaaggcac	tacaattgtc	catgttatta	tacacaaaga	33480
ataagtgtta	ctaagggcca	gccatgccaa	cagtgctctc	tacatactgc	ctcatttatt	33540
cctcacaaca	gcctggtgag	gtgggcacta	aatcatgtga	tcagaggctc	acaaaggtta	33600
agtagcctaa	gatgcaatgc	tgccacatgg	tagagctgga	actgaaactc	acattggttt	33660
gactctacac	cctaaatttt	aaaccaatcc	atcttctaca	tttcacagaa	gtgacgactt	33720
ccaacacctc	gcacttcagt	aaatctgaag	gattccagag	aagggaaagg	gttgtctctc	33780
accatctgag	tctaggagtc	aagctcaggt	cagtgatccg	gacactgacc	attttgttca	33840
cagcccaggt	ctctgcttcc	ccttgtcttc	cctacatctc	ctgccaggct	gccagctctc	33900
agcataggag	cagcaggggt	cagaggaaag	gcacaactca	atccggattg	ctgtgctgca	33960
caacagcagc	tgtgatggag	gcagcatcct	gtgcgcaggt	agtactttca	cagaacacat	34020
cacgcttcgc	acacattgat	cacataatat	agaaaaagca	tttttagttc	catgtgaaag	34080
atgagaaaat	acattctcag	atattaagag	gcctttccct	atagatatta	aatggcaagt	34140
ccaggatata	aattcttatc	ttttgactcc	aaatctagca	ttagttttat	aataaattat	34200
agcatctctg	tgttttttgg	ttttgttttt	gagatggagt	cttgctttgt	cgcccaggct	34260
ggagtacaat	ggcacaatct	cggctcactg	caacctccac	ttcccaggtt	cagatgattc	34320
tcctgcctca	gcctcccaag	tagctgggat	cgcaggagcg	tgccaccaca	ccctgctaat	34380
ttttgtattt	ttagtagaaa	caggttttca	ccatgttggc	caggctggtc	ttgaactcct	34440
gacctcaggt	gatccaccca	ccttggcctc	ccaaagtggt	gggattacag	gcatgagcca	34500
ttgcacctgg	cctctttctg	tgattttttt	tttttttaaa	gcagcctgaa	ctcatcagct	34560
gaaacaaggt	tgagataaat	ataaattcca	ataatcacta	tttttccatg	ttgcagaaag	34620
taggatggtt	aaaaactgta	tataattata	ccatccctac	ccaccccatg	gacaatgttg	34680
ctattgattt	tattatttga	aaatactatg	tagggatata	gatattctta	tgtatagcag	34740
ccattctgct	cacttacacg	atatatttca	tggtaacaat	aagagtaata	acataataga	34800
gctcatttta	tgttccatgc	actgttctaa	ggacatgcca	tgtaagtcat	ttaagccttg	34860
tatctatctt	gtgagatggg	cataatcccc	attttacaga	tgtgaagact	ggttatacat	34920
actggagtcg	gagtagtggt	acagctcctt	gtagggagag	atgtgggctg	tgaaatttgc	34980
tgRgacgtaa	ggcacctggc	cttgaatgtt	ggtcttaatg	ctcaggtagt	tctctgggtc	35040
aagtccctca	gcagtttgag	tgatacgaac	cgtctcctct	cccgggtaga	atgtaacttc	35100
catgtcatgg	gtaaaggcag	cacctggaga	tgaaaaacat	tcagcacagg	gatgaaaaga	35160
ggtcttgctt	aaacagttac	cagtatatac	tgcccgctcc	caatttctac	tgctgttgga	35220
gatcgtgcct	aaggagatta	tctgatatct	gagagtaagc	actatcagct	gttgattcca	35280
taagttccca	aacttttcca	ttgaagaata	tggtttcatc	ctgccttacc	tcacccagct	35340
tctctttgaa	caagcttgta	ttctgtgaga	aatactcttg	ggaacgtcct	tgacttttct	35400
ctaaggttgc	tagacttagc	aaaaaacaaa	caaacaaata	aacctaacaa	caaaaaaaca	35460
aaaacaaata	aactaccacc	taagacattc	agggttttgt	ttgaatttca	gataagtatg	35520
tctcatgaaa	tatgtgggta	atacttatac	tagaaaattg	tttatctgaa	atacaaattt	35580
atccaggtgt	gccatttttt	atctactttt	gacccaaggg	ctttattcaa	attttgatta	35640
aagcaagaac	ctattaacag	ctaccgagct	ctgcagttaa	agatggagaa	agaacttctc	35700
acaaaactat	ttttaatgca	ataaagataa	aacctctagc	aaacaagttt	tcaggttgga	35760
aggtgagaat	ccaaaaagta	tcttctaaat	ccttgttgtc	aacgggtggc	ctttccagca	35820
acactggtac	ctcacctcct	agcttggtag	aaaagcaaaa	tcacggaccc	caccccaggc	35880
ctgctgaacc	agaatttaca	ttttgacaag	acctccaagt	gatgtgtgtg	caggttcaag	35940
tctggggtgc	accggcctat	actattatag	gttgtggagc	tgggaggaga	agagcacccc	36000
ttccccatga	agtaaaatca	tccccaggtg	ccccaagtac	catttttgca	tttgacagat	36060
ctgtgcataa	tttaaaaagc	ctgacaaata	tgctgcaaca	aattggggta	agaggacaca	36120
aatgttctga	atggaatcat	cctgtttctc	agaacagctg	ggagaacatt	tagacgaaat	36180
cactgccttt	caaaaatcag	tgatgtgagg	tcaaaccatt	cccaacaacc	tgtggccaga	36240
aaactacaca	catgtggctc	tagtacatta	aacaagtgat	tcctctgtca	ctgcgtaaag	36300
gcctaaagac	agtgccccaa	ggagcaccac	tgccaaagca	atgctgacta	ccggccttct	36360
cagaggccct	actcacctgc	gaggctgaag	ccgttctcag	agccaggttt	ttctaaagca	36420
aagagccagc	caaacaggcc	tccaattggt	gtgaggggga	ggagggcctg	ggctgctggc	36480
tgtgggatgt	ggctgatggc	cgtgtaggct	ctgccatcat	tgcccacgat	atacgcatgc	36540
aggtccacat	cagtgaagtg	cacgggtgta	tggcccacgt	ggaggtggcc	actcactttc	36600
ccattcactc	ggtgaggtgc	ccctaaaaga	cagcaaatcc	agttaggctt	ggacgtcatc	36660
ctggctagag	atgggtgtac	ccaggtataa	ttattccact	gacaacttcc	aaaactcact	36720
ctttagcaag	tcactttaat	gatttcctaa	ccaaccaatt	atccatctat	gaaacagtcc	36780
tgcctccagt	ctgttttctc	ccctcctcct	tctactccac	tacactttgg	ctctaatgag	36840
ctggcagaag	gaagcatttc	tggataatcc	tcaaattggg	aatcagccca	aaccagttca	36900
ttcctcacac	atttattgag	cacctgcaag	ttgatagcac	tctgatttaa	gtagtggaga	36960
tgtttggtcc	ataaagcaga	gctcacagtg	gtagctggaa	acaggtaagc	agcaggaata	37020
gacacacagg	agttcctggc	cccagtcaat	taccttcagg	cagacagtgc	ttcccatttc	37080
cataaaactt	ggattggcag	tggcagcaga	agccagtggc	atagtccgtg	cagaaggcat	37140
gccgggagca	ttgtctgtgg	ttgtgttcac	aggtttcctt	gttggcagca	ttatacgtga	37200
agactgaaaa	ataaaacaaa	cttgccttaa	aaggactaaa	tgattccaat	gtcactgctg	37260
catcggggac	acaacatctg	ctccatagaa	gcagtttaga	tcataacaaa	cagtttttga	37320
tgtttaagag	accggcataa	cattcaaccc	aagggaatta	atctgctttg	tctgctggca	37380
agaagaattg	cttactgctc	ccggctgggt	cccattgcag	agttggtgaa	ctaagatgag	37440
actgcacccg	tgggtttgag	tgcagtaaaa	tgaaagcaaa	ccagtaagta	catgttaggt	37500
tgaacttcat	gaaaccacta	tttttgtggg	tcaaaaaggg	ctaaatatca	gcacttttat	37560
atggttcaac	ctaaacacat	cctgagagga	agacataata	gagaagctaa	caaatgtctt	37620
atgtctaacc	atccttcttt	tagggaacac	tgaacttaaa	aaagataata	gctggtctcg	37680
ctaccaagat	tgttttgagg	gaagggtctt	aaagaacaca	cgcacctacc	tcaaagaaaa	37740
ggcatgggga	gaaggggaca	gaggagggca	aaacaacagg	gattcaagct	attaaaatgc	37800
cctatgccct	tggcagggtt	taactatgat	gggtatggta	caagcatgat	ttccacgcag	37860
tagcagacag	cttgggcccc	actcgcagat	cttccaagaa	attatggagg	actaggataa	37920
attcagtgct	ctggcagctg	tttcttccat	ttcctactta	ttctgcccat	taaaagaaga	37980
gggccatctg	tgctgcaaag	aaatggggaa	actggagcaa	atgccatagt	tcataaagga	38040
aatagccaag	ggggtagggt	gtggcggggg	ttgtggatgg	acaggagggt	gctttctccg	38100
gggcactagg	aaatatgcca	atcccaagca	tggccaccag	gaggccaagc	ggctgcacac	38160
acctctgcct	ccacatcccc	aggaggtgga	gttggctgga	gactccagga	gcatgctgtt	38220
gagcagggat	ggcatggaat	tctagtgtga	gacacggatg	ctggcatgaa	ggaggacacc	38280
caccctactc	ttaggaaaaa	ccaagtggta	gttgtgttcc	aggtctatct	ggaaacgagg	38340
agacaggagg	ggaggaagaa	atccaaagat	caatctttac	ccagtattcc	cagggagaac	38400
agaaagtaaa	ggagctaatg	agacatagca	ttataggtac	aatgtcacca	agataaagac	38460
ctccatcagc	aaataaaaat	ataacaaagt	taacacttca	atcgcgctta	acatatacaa	38520
gctttacatt	taacaacctt	tttttttttt	tttttttttg	aaacggagtc	tcgctctgtc	38580
gcccaggctg	gagtgcagtg	gcacgatcac	agctcactgc	aagctccacc	tcccaggttc	38640
acgccattct	cttgcctcag	cctcctgagt	agctgggact	acaggcaccc	accaccacgc	38700
ctgactaatt	ttttgtattt	tttagtagag	acagggtttc	accatgttag	ccaggatggt	38760
cctgatctcc	tgacctcgtg	atccacctgc	ctcggcctcc	caaagtgctg	ggataacagg	38820
cgtgagccac	cccgcccggc	caacaactct	taatttgcac	aacaacccta	ggtagcaggg	38880
actttttttt	gttgctgttg	ttgagacagg	gttttgctct	gtcacccaag	ctggagagca	38940
gtggtgccat	ctcggctcac	tgaaagctcg	acttcccagg	ctcaagtgat	cctcctattt	39000
cagccttttg	agtagccgca	gccacaagca	tgcatcacac	ctgcctactt	tattttttgg	39060
tagggtgggt	tggggggagg	ggtctccctg	cgttgcccag	gttggtctcg	gtctcgaact	39120
cctgggctca	agtgatcttc	ccacctaggc	ctcccaaaat	gctgggatta	caggtatgag	39180
ccaccactct	ggccagggac	aattttttaa	cccgtttgca	gataaagctg	aggcacagta	39240
gactaaagca	cctgaagtcg	cataggcagt	gagtggcaaa	ggtgggaacc	gaacctagga	39300
catctagctg	gagaatctta	actgctacta	tccacgaccc	cttcaatggg	atccaagtac	39360
ggagatcatg	agcactagat	taggggtcac	cacatgtctg	gggttaatca	gcacagactt	39420
caagtataat	tcgagtcata	ctttataaac	tgggtttaat	ggtagaagca	agcagggaag	39480
attatcgaga	tgactattac	agcatgttga	aaaacagcac	aggtaagaaa	tgagagtagc	39540
agcagcggca	ttagcttttg	aacagtactg	gagtgctgcc	tgcagatcct	tgggaaagca	39600
gcaagctgag	ggttggcagg	acagacagtg	taggttcaag	tggaaaatct	gattagaaca	39660
tagtaggaat	gaagttatga	ctcaagattt	agtatagggc	cttgatgact	tggctaagaa	39720
attccagttt	gataaaaata	gaaaattagg	catgactcaa	ctttatttaa	acaagaaagt	39780
gacaagctta	acttaaacag	aaaagtgata	taaaactcaa	ggcagaaaaa	aaaaaaaaaa	39840
aaacccagga	tggatcatgg	taaaatagat	ggctgtgaag	aaaactgtat	cactgtctat	39900
tagtttaaga	aagggaaaaa	aacatttaga	gtaaaaggaa	atgaatgtaa	cttggatgtg	39960
tcaaaatctc	aggtttctcc	agctcagaaa	ttcacaacta	agtgtaagga	agcagctaca	40020
ggagggactc	acacactcac	cagtgtgctc	atggcttaag	ggccatcagg	actttctccc	40080
agagctcaag	gaatgagggg	ctgcagaaag	cgccaagctc	taggactcaa	cctcagccct	40140
ccctcggggg	ctttgtggaa	actatgcaaa	ctgtctttca	gcttcctcat	ctctaaaata	40200
agtagaacac	ctcttcctca	cccctgcatt	gccagaagtc	gcatttcttc	ttaatgtact	40260
tctgaacacc	aagtaaaaag	gcaatctgct	ataggtctaa	agaacagcca	tttggctggg	40320
cccggcagct	cacacctgta	atcccagcac	tttgggaggc	cgaggcaggc	ggatcacgag	40380
gtcaggagac	tgagaccatc	ctggctaaca	cggtgaaacc	ccgtctctac	taaaaataca	40440
aaaaattagc	caggcgtggt	ggtgggcgcc	tgtagtccca	gctactcggg	aggctgaggc	40500
aggagaatgg	cgtgaatctg	gcaggcggag	cttgcagtga	gccgagatcg	caccactgca	40560
ctccagcctg	ggcgacagag	agagactcca	tctcaaaaaa	aaaaaaaaaa	aaaagccgtt	40620
ttcataatat	tcagataaaa	atcaatccaa	actttacaag	ctgttctgcc	cacaaattaa	40680
ggaaataaca	ggcttggatt	gtatcttatt	tcagttattt	tgtgaagcct	tattctgcaa	40740
cccaattctt	attctgaggc	tgaattatga	aacaaggaga	gagaagatgg	aggagagaca	40800
gtctagatat	ggagagttaa	actaggtgga	gtcatagctt	ttatctaagt	aaaaagaggc	40860
agggcgatgc	agccagcaac	ttacaagtgc	aactgtgcaa	aggtttataa	atagattgga	40920
agctgtacta	catttttcta	ttacagaaaa	agaagttata	acaatgagca	ggctcccatg	40980
aaaggctatt	atgagactta	aactgtaatt	acaatgggct	aactagttac	tgttaagcta	41040
acctgggagt	ctttttaaac	agttttgtgg	aatattgtat	ttttaggatg	gtacttactg	41100
agccaagaac	acacactgtc	tctttcagct	tcataacagc	cacatgaagg	aaagaagatg	41160
gatcagcccc	taatccgggg	gaaggcaagc	ctccatttat	aatccctctt	ccacgcctgc	41220
cttcataccc	aagtgcacac	acaggtttgc	acacttacca	tttacaatgg	cagcttgtta	41280
ggtgaaaggt	aaatgcttct	tacaattttt	gttcattcat	tcactaattc	aacaagtatt	41340
tactgagcat	tcactataga	cctgtaccta	gtctagaaac	tgaggacatg	gcagggagca	41400
aaagagacaa	aaattcacat	cctgaagctt	acattctccc	cagcagcagt	caataaacaa	41460
gtaaattact	tagtggggtg	gatgtgtaag	agctgtgcaa	agaaatacag	cagagaaaga	41520
caagagggtg	ggagggggca	ggtgtacatg	gctcttttta	atagcatggt	cagggaagac	41580
ctcaggagaa	ggtgactgag	cagaggccag	gaggaggtga	gggagtgaac	cccacagatg	41640
agggcaggcg	tggtgctgtg	tcaggcagga	ggggtgtgtg	ggcatgtggg	agggatggtg	41700
agagaagagg	tggcctgggt	cattcatgca	gggtctcaga	gatcacagga	aggatttgag	41760
ctttcatctg	agtgagatgg	gaagcactag	agggtttcga	gcagaagagt	aacatgctcc	41820
gactacagta	aatcagacag	gagctggtcc	cttggtggta	agaagtgctg	gtacagggga	41880
taagaagggc	ccaggtctgg	gatattctga	aggtggaacc	gagagggttt	gctggtagac	41940
tggatgtggg	atgatgttca	gtcctgatgt	gggaaaccaa	aagggtggag	ctgccagtta	42000
ctgagatagg	gagactgagg	aggagcaggt	ttgtggggtt	cagttctgac	aacagcatga	42060
ggcatcaagg	aaattcacca	aggggtgaat	aacaacttac	accctcagca	cagcaccatg	42120
cagtccttca	cacggagagc	tgcatttctc	ccggtggatt	ccagagacca	ctgcatcagg	42180
atcacctgag	atttctgtta	aaaatgcaaa	ttctgagggc	ccaccttaga	cctaccagtt	42240
ccactctctg	ggtgcatcct	agcaatctac	actttagcca	ccccgccagt	gattctcaca	42300
ccaattggtg	ttgatagaag	gcttgggata	caacaagcct	tggatttctg	agctaggtgt	42360
tgctcatcaa	tgtcgttaac	aaatttaatc	tgaccaattg	gcagctcctg	gggtgggcag	42420
aatgttagga	aatttctcgt	gctcatttct	ggccacctga	gaagctgagc	tcagtgctta	42480
cggcccattt	gggcatccat	ccacaagaat	acaacgtgaa	gattctttag	tgaaagtaat	42540
acagacgcac	agcagccaga	tagcccttcc	ctgaagaagg	gggagacctg	gagctagaac	42600
ggtgctgagc	ccacgtgcag	ctatttatcc	agggcgagaa	aagccagacc	tccggccaac	42660
gtgactgctc	aaatttctat	gggaattgca	gtgaaattca	aagaggctga	acttcttgaa	42720
ggctgggaat	caagatctgg	atcccagcta	gatgagatgt	gcaataaacc	cacccgagga	42780
aaagtggcac	tttttctttt	cggtggtcat	tttcatgtcc	ctatcatggc	tttgagtgta	42840
ttttcatgca	cttcttccta	ttctagttag	aagatatctc	cattttataa	atgagaaaat	42900
tgaggcctac	agagatgaaa	caatcttctg	gctctaaatc	ccatcaaatt	gagggggcat	42960
cagaatcact	gaagtgcaga	ggaatatggc	agggtcagac	aagagggtga	gagagggcag	43020
gcacacctgg	ctctttgaaa	tagtatggtc	agggaagacc	tcgggagaag	gagacatttg	43080
ggcagaggcc	tggaggtgtt	gaaggagtga	ggtggcttaa	aaatgcagtt	tctggttcag	43140
aaggtagagg	aggcgcttgg	aaatcagtgt	ttttaaccag	gctcccagct	gagtgagagg	43200
aaggtggatg	agtgcccaca	ctttgagaaa	tacagtttct	agtccatggc	ctcctctggg	43260
acccacacta	tgccaggaag	ctcctgccac	ggagagtcag	accataaaga	agtttgctga	43320
cacctcaggg	cacagcagga	gggtggaggc	tggccaggtt	tgaatgaact	cattttgtca	43380
tggatttgtt	aactgaggtt	tgatagttgc	taaaggattc	ttaacatgaa	gattttttaa	43440
atctcttttt	tttctattta	atgttttttt	tgtttgtttt	taacttttct	catgtcctta	43500
atagaaagaa	aaatggggtg	gggagatatc	agaggaaaga	aagaaatgcc	ctgccaaagg	43560
acttgagact	tgtcctaact	aggagttcgt	aacaaaaatg	gaaaattctc	ctctgcactt	43620
gttctgagcc	atctttcaat	cttcattttc	ccagaaacac	ttaagcacct	gtctgcagcc	43680
cttggccggc	ctgcccttct	tcacagaagg	ccctgggcca	gacacagggg	aggttccatg	43740
gtgtcgactg	ggttcactgg	gccaacacag	agggacacag	gaggcttcgt	gcacagggct	43800
gcttcaggac	agctggagca	actactaaca	atttttactg	ctacctcaaa	aaaaaaaaaa	43860
gtcattttca	ccgcaggaaa	aattcttcta	agttttccca	tctctcagaa	tgacagacta	43920
gttagaaaaa	ccatatccaa	ctttataaca	aacagtggaa	tgctttttcg	tccagttttc	43980
atgtttgttt	aattttgatg	tgtgtggcat	gtaatgatgc	tggtggcagt	gatcacgacc	44040
ctgggggtgg	ccttttacaa	ctgctggcat	gacactaaca	ggctctctcc	acttctggtg	44100
aagggagagg	ggccctacca	tggaatctcc	tcatataggt	gtcttcacag	gcatcggggg	44160
gcggcggctc	ctggtcacag	accctctgca	acctggaggt	gcacccaggg	gatggtcttt	44220
ggcacctgga	gggttgcact	ggcagcagaa	cctgcttaaa	ttcttctcag	ggtggaagtt	44280
gagcttgcaa	cacactcctg	cagcctttca	caaggccaaa	agtggagtgg	gactacatga	44340
ggtttctgaa	agccaggtgt	ccttcctcct	aactcatcat	gcagattgag	attaaattaa	44400
gctgcgtata	gcactgcctc	agcaggctta	agaataacta	agacccctat	cagtaaacct	44460
cattcctttc	tactcacaac	acaggcagtc	ccatggtccc	aggcagctga	agccctcact	44520
ggcaactctc	tcaccccact	gccttaatca	acctttgtct	ctgtctctct	ccctcctttc	44580
ctccctcctc	attcccatct	ctgcaactcc	gctcttgtca	cttctctgtt	cataatgttt	44640
tcacacattc	tccctctcag	actttgaccc	caggcctggc	tcaagcccct	ccttcctcac	44700
aaagacttcc	ccaacagcag	tgacactcct	ggacagtgcc	tttgactctc	tgtcacccta	44760
cagctttctc	taatttcttc	atgactttgt	tgcagtcttt	gcccttgcta	gacaagtcac	44820
taagtatttc	caagctcagt	ttccatctct	gtaaaatggg	aaggatgatt	gtacctaccc	44880
tacaggacaa	cttttttttt	cagacaatat	ttctctctgt	tgctcaggct	atgcagtggt	44940
acaatcatgg	ctcactgtag	cctggaactc	ttgggctcaa	gtgatcctcc	cacctcagtc	45000
tcccgagtag	ctaggaccac	aggtgagcac	caccacaccc	ggctaatttt	taaaattgtt	45060
tatagaggca	aggtctccct	atgttgccca	ggctggtctc	gaactcccca	cagggcaatt	45120
ctgaggacta	actgtgataa	tgcaatctaa	tgccaagttc	tcactttaga	gcagcaggct	45180
gcacttagca	aatgccagcc	aaaacttcca	ctagcaccga	gtcagagaca	ggtacacggc	45240
aggtgcttgg	gtaacttttt	gacttgacaa	caaaacgacc	agagctccct	ggaaacaaga	45300
ctcctcagag	aaagcatgct	tgcacatcca	tctactgctg	ttctgtggcc	taggaagaca	45360
gagctcgagt	gtggccagga	cattcctgcc	tggtgtagat	atgatctgaa	aatctaaatt	45420
tctgaacaaa	aagaaaggtc	tgtaaaatga	gtccctaagg	ggaaaaaaat	gtaaaaagga	45480
gtgatatttt	ctgggccttt	aactaaatct	taatttcttg	gtttagcaag	atgactaccc	45540
taaagcttca	aagggaaact	aaaatgtatt	gggcagggtg	cttcccaagc	tcaatttcag	45600
ttcttgcaag	tatatgacga	ggtcttcatt	aactctgttt	tagagctgag	gagagccaag	45660
ggtcaaacag	actacatgtc	ttgccccaaa	ccacatagca	gagctgggag	tcaaggtcaa	45720
gtccaaccag	caccaaaacc	atgtgctttc	tattccatca	gcagaaaaag	ccaggcagat	45780
gccacatggc	tgggtactta	gtaccggaca	atgttctgtg	tctctgccac	tcccacccca	45840
cagcttcccg	gaggaagccc	acacttacca	gacagacctc	tgagcctcca	atgttttatg	45900
tgaaagaaac	agtcactgca	tcccctcaaa	agtatttaac	aattgcatgc	ttctatactt	45960
catacatccc	cgtaaattct	tttaaaacaa	aaactggatt	ttttttgtct	aagtttcaaa	46020
cacttctaga	tttcttcctc	caaaatgcgt	attaaccagc	tttttcacag	gcgttttttg	46080
ccattaccag	gatgtctata	gtagactgca	tccggcagct	gataaatatc	atagttcatg	46140
ccccacaagg	gttatagctg	tgcctctgtt	ctactctatg	gctggttcct	gaagcctcct	46200
gcactttact	ccagtgatct	caagctctca	gagcccaaag	cagggtgtgc	agtcccttct	46260
taacccttta	atacatgact	ccatagatct	gctttttaat	attcccacgc	tcttcccagg	46320
gaaggaaatc	acaacccaca	aatgagaagg	ccattcagga	atgcgtcttt	acctcaaatc	46380
cctttgtgaa	aatctttgat	acttggcctt	aaaatgtatt	tagaggaaac	tcatactgta	46440
aattctggag	attctcagaa	ggatctgaag	gttctaaaga	cttccaataa	aatttacatc	46500
ttcaacttca	tggaaatgtg	gtcccttagg	cacaaattaa	tgtgaaactc	tttaataagc	46560
acattcttca	ttctctaccc	atcctccacc	ccattcccac	tgttttaaat	cttctaaaat	46620
tagtaacagc	agccactatt	tattaagaac	cagtgagtgc	agacacgaag	ccaagaactt	46680
cacatacgct	gtctcattga	atcctcccaa	gtaattcctg	agaaatcaga	ggcttatggg	46740
ttacataagt	tacttcaggt	cacccagcaa	gcttggcagc	caggattcaa	actcgaagcc	46800
gacaccaatg	tactccctcg	aatccttaca	caatgccaca	ttagtcagaa	aatattttct	46860
tccctcctga	aattagtacc	tctccatgca	atagcctgca	gataatacca	gagcagaacc	46920
cagaaggccc	tctctgctag	gtcagccatg	tttttgccac	aacagtgaca	ggaaacagaa	46980
aaggtggaaa	aacatggaga	ttcagaacaa	agcagtcacc	tctgacctct	ttcttcctat	47040
cagaggtcag	atgagcagtc	cctggaacaa	acaatctgga	gtcagtttcc	cattcacatc	47100
tttccatgtc	tgatggggaa	gaaacagctg	gcatgacaag	tctcaacaag	gactagaaga	47160
ctgacataga	ccccatgtcc	atgataatta	accaccgcct	gctttcgcca	tctccctcct	47220
cgcctctcag	tccgatcagt	gggtcatgaa	atgaggacaa	ggctccaggg	aggttcatgc	47280
cacagctgca	tagccatgaa	ccagaaatga	caacagacac	aggtgtttag	tcattttctt	47340
tccctgtggg	ctctcctctc	ccacacatca	caagcatatc	tccccaacca	agggaagcgc	47400
taggcttgtc	tcacaacaga	gtatgaatct	ggcatgttca	tctgagccag	cacaactcac	47460
cactttaaaa	agcacaaacc	cgtccatcac	tggaatgtgt	atgaagccgc	aaaatgtttt	47520
acctttgctg	aactttcaaa	ctgaaatagt	tcattacact	tgagagcgta	gctggcataa	47580
caaacccagt	tttcccccac	tcacttcatg	aggcccatat	ttttaaaaaa	cattattaat	47640
gatcaagaga	ttccgaacag	aatctgcctg	ccaagattta	tttggcaaag	gaaatttact	47700
ctatctcttg	aaacacaggg	attaaaaatt	agatccaatc	ttctttttgc	taaacttttc	47760
acctacccac	ttaagagaaa	aatcacaacg	ctatgcaaaa	ccagcatggt	taagatgaaa	47820
ccttagcacc	cagttttcta	atgcactcac	cctcggtgtt	ggaacctatg	ttgtcttcca	47880
gtcccacctc	atacgtccct	cgacttaagg	gtgtagtgtg	acctgaagca	gggtaacttc	47940
gaagaacaat	ttcttcttca	ggatgagctg	ggggaacatc	catttccgaa	ggcactggcc	48000
ctccatctgg	gtagggctgg	atgcttccgt	tttcggggta	cggtggtggg	gtttcccagg	48060
aaggagccag	tgaatctctg	tctacctctg	gtggagctgg	gcttctggtc	tctctctcat	48120
cccagggctc	aacttggcct	tttaaatctg	ggccccctac	ctctcccaga	gatgttcctt	48180
ctttggtgtg	aggatccaag	gtggaagatt	ctgtttcagg	atagaatggc	caataagtag	48240
gtgttggatg	caagggggag	gacagatcag	aatctggagg	ggagatccta	ccctctaaag	48300
gctttgtatc	cactttggat	tggaaggaaa	catcaatgct	gctgtggcca	ttcaatgcct	48360
cctctggttc	acccggaagg	tattcagctt	cctcctcatt	cacatcatag	taatccaaat	48420
tgtcctcatt	atagtcactt	tccagggctg	tagcatggct	gaaggaacgt	cccaggggaa	48480
cagaagagtg	ggcagcggaa	aggtctccaa	ctgcagctgg	cctgacattg	tccaacgggg	48540
aagtgctgcc	gatatggaaa	gcccacactc	cagggatccc	caggttgctt	agtctaaata	48600
aaaaggaaac	agtcattgta	acaaatgtaa	caaaagtgtc	cattcaccca	ccttcctaga	48660
aggtgaacaa	cttattttaa	aacggaaaga	cagctgggca	tggtggctca	cacttataat	48720
cccagcactt	tgcaaggcca	aagtaggagg	atgacttaag	cccaggagtt	tgagaccagt	48780
ctaggcaaca	tagtgagacc	ctgcctctac	aaaacccttt	tctaaaaaac	ttagccaggc	48840
atggtgccac	atgcctgtgc	ttctagctac	tcagtaggct	gaggcaggag	ggtcacttga	48900
gcccagcagt	tccaggttac	agtgggcttt	ggttgcaacc	actgcacccc	agcctgtgtg	48960
gcagagtgag	accctgtctc	aaaaaaacaa	aaaacctgaa	aggctattaa	gatcaggttc	49020
agttttcact	ggtatataaa	accaaataaa	agcagactta	catggtaact	aaagggatca	49080
tactggactt	ttgatgtgaa	ctacctttta	tttaacatta	tgtttcaaag	ctgtatgcca	49140
cagaatgcca	gatcatcaaa	ttatcaatct	gccccataat	ccaaatggtt	tatctaaaat	49200
ctggctattt	gaaaataaac	aaggaatgta	ggaatgtttc	atccttcctc	tacttgtctg	49260
gaaacataac	acattttaaa	aatgtatgct	taaaactcta	ccaaatactg	acacccaaat	49320
gactacgaca	tactttcatg	aattggtgat	gccccttccc	tgtgccaagt	gtttcacatt	49380
cttcaataca	atctgcaaat	agaaatgatc	atattcaatt	ttatagaggg	gaaaataggc	49440
tttaaaaggc	taactgatct	tctgaaggtc	acataacaaa	caattggatc	cgaattcagt	49500
taacaccaaa	gcccatgctc	tactcatcta	tgttatatta	tgacagaaaa	ccataccaca	49560
cactgcagtc	aataagcatc	tgaattatca	ttactctaca	gaatattaaa	gacatttcat	49620
tgtttattca	cttgaactga	ttaattccct	aatccacaaa	gaatggtgag	tcaatgtaaa	49680
aaaattcaaa	taaatacaaa	tgccaaaacc	taaaaaattt	gtttttgcac	tgaaaaagtt	49740
aaggagcaaa	taagaaagta	gcttagaagt	cttttaaaga	cttctggaaa	cagctctctc	49800
gttttctcca	tgagaaaaga	acatgaactc	cattgagttt	ccaaatatcc	caataaccca	49860
ttattttaga	gtcaatggta	taccctaaag	agaacaacta	catatgattt	ctaaaaatat	49920
ttattttaga	gtcaatggta	taccctaaag	agaacaacta	catatgattt	ctaaaaatat	49920
gggaaaactt	gagtgaacaa	gagtctggtt	aggttgaata	tgccagtttg	tatactcctc	49980
tgatatttgt	acaaaacact	atgctcacat	tctcccaagc	aatggaattt	cctcaaaagt	50040
cagtcaatga	ggaataacag	tccatgccta	ataagataat	aaaaacttca	ctaaattgta	50100
taagaacaaa	agattttcct	tcatttgggt	gggtactcat	catgttcatg	tggatttcta	50160
tagtaacaat	atttttcagt	acaatttgaa	aatgtctttc	tcttgtgtgt	gtttgtgtgt	50220
gtgtgtgtgt	atgcatgtac	atatatgtat	atgctgtggt	tactgttgtg	gtaaatttag	50280
ggaaaaaagc	atagaaagaa	aaactgattt	tgtgtgcaat	atgctataca	tatttgttaa	50340
gttcataaga	attaatgttg	gtgtttattg	gcaagcaaat	aaggaaaact	aaagacagta	50400
ggagaaaatc	ctgaagttct	gaggatattg	agtttattat	cacattagag	gtggtgcaac	50460
tatgaaattt	cttcttgaag	ttagaaacag	aaactataaa	atcttcaaac	agtggaaaaa	50520
tacagattat	ggccaataaa	agctaaataa	aataaccttc	taattatata	taaatcacta	50580
tctgggtttt	gtcattatgc	ataatggaaa	agtaaccaat	ttgagtttat	tttaaaatcc	50640
aaggtcattt	ggaaagctta	gtaatagaaa	gaacttaatt	tatttctaca	aaggaaaatt	50700
gggttacaaa	atgggatgac	aatgccttcc	tccctgggtt	gttaggagaa	ttaagtgaga	50760
aaaccacatt	aaaatgccta	gcactgacca	ggtacggtgg	ttcatgcctg	aaatcccagc	50820
actttgggaa	atcaaggtgg	gcggatcacc	tgaggttagg	agttcaagac	cagcctggcc	50880
aacatggtga	aaccccacta	taaatacaaa	aaaaatagtc	aggtgtgatg	gtgtgtgcct	50940
gtaatcccag	ctactctgga	ggctaaggca	gaagaaaagc	ttgaacccag	gaggcagagg	51000
ttgcagtgaa	ccgaggtcat	gccactgcac	tccagcctgg	atgacagaac	gagactccat	51060
ctcaaaaaaa	taaataaata	aaatgcctat	cactggccct	aaacatcata	aatacttatt	51120
aactactgtc	ttgtcttcca	gaagatagaa	aagtatgatt	tcaaaatata	cacgtgtgaa	51180
ttcgtattta	aatttgcaga	ggaagagtat	gacaaacatt	atgaactata	taatttatga	51240
cctttgagct	cacagttgtg	agacaaattt	gaggaagaaa	acaattgact	aggaaaataa	51300
ctttactctt	aattacttat	ttatttagag	gtagggtctc	cctctgtcac	ccaggctgga	51360
gcatagtggt	gtgattgatc	atggctcact	gtagcctcaa	ccccctgggc	tcaagtgatc	51420
ctcccacttc	agcctcccaa	atagctgggt	ctacgggtgc	acaccaccac	acccagctaa	51480
ttttttaaat	ttttagtaga	gattaggtct	cgctatgttg	cccaggctgg	ccttgaatgc	51540
ctgagctcaa	gcaatcctcc	caccttggcc	tcccaaagcg	ctgggattag	aaccaccttg	51600
cccagcctaa	ctttaccctt	aagagatgca	tactaaggca	tttagcaatg	aactggcatg	51660
atgtttgtga	cttactttaa	aacatttaaa	caggccgggt	atggtggctt	acacccataa	51720
tccctgcact	ttgggaggct	gaggcaggtg	gatcacctga	ggtcaggagt	tttagaccag	51780
cctggccaac	atgatgaaac	ccagtctcta	cgaaaaatac	aaaaattagc	cgggtgtggt	51840
ggtgggcgcc	tgtaatccca	gctactggga	ggctgaggca	ggagaattgc	ttgaacccag	51900
gaggcagagg	ttgcaatgag	cacaagatca	caccactaca	ctccagcctg	ggcgacaaga	51960
gcgaacctcc	gtctcaaaaa	aaaaaaaaaa	aaaaaaaaag	aaaagaaaaa	aatgtaaaca	52020
aacaaaaaaa	tgaatatggc	aaaatgttta	caatgtataa	atctaggtga	tgggcatttg	52080
ggtgttcatc	tagttattct	ctccactttt	ctgtatattt	ttgaaatttt	aaataatgaa	52140
aagtgaaata	gaagattata	ttgaaggaca	tttctataaa	tttgatgtac	agaagttctt	52200
cctaagaata	acaacaagat	ccaaaatcag	aaaggaaaag	accagtaact	ttgacaatct	52260
gaaatgtaca	acttttaaat	catacaccct	ttctcagcaa	ttccactttt	aagaatttgt	52320
tttagggaga	aacgagaatg	tgagcaatgt	ttattatgct	gtttactgca	atgatattta	52380
taacaagaaa	aatcagaaat	acatgaaatg	ttcattaata	agctgtcttt	atacatatat	52440
gacataacgt	tttgtagcct	taaaatggta	gtatagacag	acatctgact	aaaagacccc	52500
tataagaagt	gattaatgtg	aaaacaccac	ttacatagca	aaagaaccat	tttggtttta	52560
aaagttttgt	atatacctaa	attctagaag	gaccattaac	acttgttatc	acttgaagta	52620
gtgatcatgg	ataactttta	cttttatttc	acattattct	gcattgcttg	tactttatta	52680
tttgtattaa	gcatggatta	caataaagaa	aaatacgtga	gtcatttggc	cccatatctt	52740
actctgcttt	cgccaagcaa	ttcagagatt	tctgggaagt	atcaaagata	aaaatgaggg	52800
aaggcatgaa	agggggtaag	tggaaatgct	gtctgtgtgt	ttgtgtgtca	cacgtgattg	52860
tggatgttag	ttccaagaga	cctttatggc	tctgctcagg	gaacacaact	gctttttccc	52920
acaggtcttt	tggccccact	gtctcctgtc	tcctgtgtag	atgccagcac	ttacccaggg	52980
ctctgtaatt	gttgatctat	ttgtctatca	accctaatag	ggtacaagct	gctgatgtgc	53040
aggaccagtg	tcttagaaat	ctttgtattc	catgtgcttg	gccattgtga	cctctctata	53100
ataataaatc	tatggaataa	taaatctatg	agctcccaag	tagaagagag	ggtggaacca	53160
gaggagggag	agtaaggaac	tgagtttgct	ccagagtcca	gactaagcgg	cagcctagat	53220
ggagccctaa	agatgcccaa	tgtggatcat	aaggatggga	aaggaaacaa	ggactcagca	53280
taagataaaa	taagtagttc	agcactccag	acttgagctt	ggattttggc	tttgccactt	53340
aactttgaga	tcataggcaa	tttacttaac	ttccctaagc	tcctctgtaa	aactgggaaa	53400
atagtagtac	taacctacaa	ttcttgtgag	ttttaattaa	gataacatct	ggaaagtgtt	53460
tagcatgatg	cttggcaagt	agtaagtttt	caataaatgt	cagctctgag	taagcaaacc	53520
tggctatagt	ggtctctttc	tggtagccga	gcagagtgga	tggcatgcta	aaagtgtaag	53580
gtgtttctat	acctacccag	gattgattta	atgaagtcaa	gaagcagtta	aaggaggcca	53640
ggaagtaacc	aatgtattct	atctggcttc	tatattcagg	aaacgaataa	aagcgagggc	53700
acccctacct	cccctcacac	accccccaaa	aaaccctgaa	gtcaataaat	atcctactgg	53760
cactatctgt	actggcaaaa	tgcagaagag	cttattattg	cactagctaa	gtaagccctc	53820
tggatcattc	attcattcac	ccatctattt	attaaatgcc	cattatgggc	agacactgat	53880
gagtctaagg	aatgggttca	attcatttta	ggtaatgaag	ccagagagac	atcctcagac	53940
ttctggaaac	ctataaatct	tagttatttt	tcctgcaaat	tacattgctc	aatttaatgt	54000
ttaacagtat	ctgtccaaaa	gactaaatca	caatgtttcc	tcctgtgaaa	tgattaatct	54060
ggaaaacctc	aaactgggca	gtttatgact	ggatattttt	atgtggttcc	aagagcaatg	54120
tttttcatag	caagcctcag	tggctctaca	aatacacaca	catactgttc	tgtttccagt	54180
atctataccc	aatagagcag	gaaaaataaa	ggacctttta	tgttttggtg	aacttgatcc	54240
ttccagggtt	gaatctagtt	ccttggtttt	gacttgatgc	cttacttaga	agccaccaat	54300
atattatgta	atggtcttat	ggtcacttgt	gttcaggtac	ttcctaaaag	tccttatatt	54360
caaataggaa	agggcttcag	ctcaatgtta	cttactgata	gagatttttc	acagactgtt	54420
cagtgctagt	caagctgaaa	tatggtcctt	ctgacttcag	atcatcagcc	tcccctcggc	54480
agaagcccac	ccgagctgga	agctgaagct	ggacattgta	agactctttg	gggcgggttc	56540
caaggaactg	caggccgttg	gcaggataaa	gaaagagggc	gtagctatca	gacccatcag	54600
atgccaaaac	tgcctggaaa	gtgttcagct	gtgaggaaaa	aaaaaaaaaa	agagagagag	54660
agagagagaa	acatcctgta	aaaaacaaat	aaaagaagaa	agaaacagaa	tgcaagcaaa	54720
gcatcataac	gtgcaaagaa	cttccccttt	ttcaggattc	ctccaaattg	tttttaaaca	54780
taaccttctt	taaaatttcc	tcttcaagtt	aacaatataa	tttcataagc	aatattattt	54840
attattgcaa	ataccatttg	tcaatttaga	ttaatagttg	aaatacgcat	tggtaaaaca	54900
taggttaaaa	aatatatact	ttgtaaggtt	tcaaacttct	ctcatgtaaa	ctctttcaga	54960
gctaagagca	atcagcaaaa	ttaacttgtc	catcctgcag	tcactgccct	agtttataac	55020
cctaggcact	cagcatctct	catttgcatc	attcattcat	tcattcattc	atccatttat	55080
taaatgacca	ctatgggcag	gcactgtgtt	aggcactagt	tggtcaaaag	gcctccttac	55140
tgtctcacag	catcactctc	tttcctcttc	catctaccct	ttcatacgag	catcagggtt	55200
atcctcattt	cacagatgag	aaaaagacac	aggggctaac	aggtcttcct	caggtcaggt	55260
ggcaagtatg	tggtggtggg	ccagccagct	ctagagccca	caccctagga	caccctaacc	55320
cctcctcaac	atggcattca	aggtgagttg	taacctggct	gcatacgtcc	ctcccaggct	55380
cagttccact	gcatctttgt	cagactattt	aatagtcccc	atttgtacca	tgtccttgga	55440
tgcttctaca	ctttgttcgt	ggttccctgt	gcctagaaag	cctcctaacc	ttcaaatgct	55500
gccactcaga	ggtgtttgtg	attccctata	gaataatttc	tgttctctga	acctctgtaa	55560
cacctttatg	ggcatctcta	gtgagcattc	acctcattat	gcttggttag	ttgtttatat	55620
gtttgtaaac	accattcatt	tattcattca	tacactaatt	caaacagcca	agtgtctact	55680
taagcaccag	acgttatgct	tgatgctgag	gatgtgaagg	agcaaaagac	aggctttgcc	55740
caggagagtc	tcacggtgta	ggactgggaa	acagccatgg	ttgaaatggt	aggagagtca	55800
ctggagaagg	tggtagaggc	caagagccgg	ggtgtgtgtc	caggatctca	gggtggaggt	55860
tgggaggtgt	cacagaggca	gctggtgaat	gttataaaca	ctgcaggagc	caacacagac	55920
cagagaggga	ccaggagcct	gaatcagctg	ccaattcaac	acccaggtcc	ttataggatc	55980
actccttaac	attctgttta	ccctcatatt	ttcaacaaga	tgagattttt	gcctttacct	56040
tcattcagcg	accgctcctc	ctaaagatct	gtgaacagtg	cttgattctc	aaaaagctgt	56100
tatgtttagg	cttctgaaac	tgtctctctc	tcactaaatc	acactacttt	tacaatttag	56160
taaggaactg	ggaaggtatt	tttaaaacac	aacttacttc	acaaataatg	tgactcttag	56220
aaatattatt	tactggtaag	tatcattacc	tttccattct	gctagacaga	caaactcggg	56280
cacagagaag	aacatcacat	ttcactgaag	gaaacagcaa	ggaaggaatg	ggtccttccc	56340
tttgttctaa	gtctactccc	acagttgttc	tagctctttt	ctaatgttaa	tttttccttt	56400
caatgtttaa	tttcaaagta	aggttttgag	gttttgctaa	taggataaag	aaatatagat	56460
gtaacacact	tttcaagaga	aataaaaata	caatcagcag	ttcttttagt	tctctaaccc	56520
agaaaaaaca	acatcttgct	ttgctttttt	cattcattca	attcacaaag	taacaggtgc	56580
ctagtttatt	tgttattgtt	ccagttgttg	attgttcatc	agcaaagctt	gacttttcca	56640
aaaacaaaaa	gcaagaaatg	tttttagagc	ttctcaatac	taggaagcca	caactactgc	56700
caaatataaa	caaaggctgt	tctgcctcat	gtctatccat	aagatagtcg	acatcatcaa	56760
ctaatgtgga	ctcaataact	tcagagttat	acattagtca	gaataaagaa	aaatcaacta	56820
gggaaagaaa	agtactagag	gaaggagaaa	aaaccccatt	tcaaaaagct	aagctttcaa	56880
agctcctggc	attgatctgc	cataataaat	gtgagatagg	agagaatcct	ggttctaaat	56940
ttagagaaat	tccataagat	aaggaggttg	tagagactgt	gaagaattga	aggggatggg	57000
gaagggggga	agagagtagt	aaacagagct	gtgaagagga	gagtctgact	ttttgctgtg	57060
aactctgggc	atttagcact	ttattttatt	cattcattca	ttcaaccagc	caacaaattc	57120
atttcaatta	aaatttattc	aacatcttct	atatactgtt	cttgagatga	gcactcatta	57180
tgggtggcaa	gtatttaatt	tctttgtctc	caccaaaata	ggcaaatatc	agaggaagga	57240
aacaacttcc	ttttaagtag	aatttatgat	cccaaagtac	acgccaaaag	agtttggctg	57300
tttaaaagcc	acccacacac	taaatgatca	cttgtaaagt	tcttggtcag	ttctacaaaa	57360
ttctacatct	aattgctaaa	gagcccactt	catgaagtct	tgaagggctc	cccctctcaa	57420
aaaactcctt	gactggcttc	caaacaggaa	aggtcctcac	attcctagat	acaagctttt	57480
gcaagagccg	cacaggctct	gtctccaaag	agaagccctc	agatgggctg	ccaaacctga	57540
caaacgagtc	actggttccc	agctccccca	ggatcccaga	gaggagagag	gggcctccac	57600
agggagagga	gcagcacaga	gaggatcagg	gtgagtggct	gcaggccctg	ttatcagaaa	57660
gagagaaaag	ccagagccct	ctgcagaaac	cagagcctga	ctctccctcc	caggtacagg	57720
acatcccaat	caatgttgaa	gtgacactca	tcagagccag	gctgatgcat	gcaacataca	57780
cccctctaag	agtttctaat	tttttcaatt	catttaatta	actgcagcta	tctggacaaa	57840
aatcagaata	gtgacatcct	tttcttcaag	gggcttgcct	atagaggctt	atcaaaatga	57900
aaatgaaaat	ggaaatgaag	aattagggtg	actcttatag	gggtcacaaa	gttctctttg	57960
tcatcttcct	caggaccaca	tgtcctctag	agctctagga	tcattgggtc	tggcctccag	58020
tgtttgctgt	gaacactaac	ctccattcct	tagtgtagtt	cttcatctcc	cactgcctgt	58080
aggacactgt	cacatggggg	actgtccctc	atttatttta	ctgcactaaa	tcctacagat	58140
cctgccaaaa	attcaaagac	aaatgctgag	tgctatcaca	tccctaatac	tatatccttc	58200
ctgatactct	tcagcaaaac	gtcagcattt	ctaatttcca	tatatggttc	agcattaacc	58260
aatttccata	tatgtctcta	ttctcttcat	cttcacagta	atatctcaga	ctcagtctga	58320
actctcttgg	atgggctgta	gaccacccct	cttctaaacc	ttgtctccag	aagtcaaaaa	58380
gctacaataa	agtcctgctt	ttacctctca	ttttctctgt	gaaatccaac	cacctccatc	58440
aatgactatc	aacctttgaa	ccaagtcaac	atgtctcagt	ctccacccag	atggaggcct	58500
ccattgggca	gtgtcttaat	ttgtcttctg	ttgtttacaa	caaaatactt	gaaattgggt	58560
aattcacaaa	gaaaaggaat	ttacttctta	caattatgga	ggctgagaag	tccaaagttg	58620
agaggtcaca	tctggtgagg	gccttctggc	tagtggtgac	tgcagagtgc	cagggtactt	58680
acggtatcac	atggcgacaa	agctgagtgt	gctaatgtgc	tagctcaggt	ctcaattcct	58740
cttcttataa	agcaaccagg	cccactccat	gataatccag	taatccatga	atgaataaat	58800
taatccattc	ctgagggcag	agccctcatg	acccagtcac	ctttcaaagg	ccccacctct	58860
caatactgtc	acattgagga	ttaagtttca	acatgatttt	cagaggggac	aaatattcaa	58920
ccatagcggg	caaccttgca	ctcatctgtc	ttatgttact	gcctgtgact	ccttcatcca	58980
tttctctggc	ccctttgcta	ataggttgct	ctctcaacct	tctcctgggt	catgtttttg	59040
ctcagaacaa	tctctcttga	tacctcattc	tcaatatcca	ttctttttag	ccctttcaac	59100
ctgacttaaa	ttccagataa	acaaaacatt	ccccacatta	cagagatcta	tataactcag	59160
ctgtctctaa	ccccatccct	aaaatgacaa	aaacaaaaca	ctcctctttc	cccacaaaaa	59220
gcacagctaa	acattagtcc	tctatgtctc	ccatcaataa	gtatttcaaa	ggtctacacc	59280
ataacttttt	tgctctgtga	actacctatg	agagttcaag	aaatctcaga	ttaactgaat	59340
tgacaaacac	tatttgttca	catttttttt	tcagatacaa	ttacaccttg	acattcctgc	59400
aatatcaggt	gcaacatctg	gtcacacctg	acaggaatat	ccatggagaa	aaagggcacc	59460
aactgcaatt	gtttttaatg	gcaaagatgc	cattgctttg	aatcttccag	tttccagtaa	59520
ctttgcaata	taaagttagt	aagccaaact	ttaagaacgc	catgtagaac	tcagtccttc	59580
aagcaaatta	gattactgtt	tgccaaagtc	tatctccaaa	gaactattaa	aacaagaact	59640
caagtcccag	agctctttaa	aatattggaa	gaaacttcaa	tgtgggtaat	tgaaagaaca	59700
tcccctatcc	aaacagaatc	ctcctttctt	tttttttttt	tttccccttt	cttttttatt	59760
tatttattta	tttatttatt	tattttttat	tatactctaa	gttttagggt	acatgtgcac	59820
attgtgcagg	ttagttacat	atgtatacat	gtgccatgct	ggtgcgctgc	acccactaac	59880
gtgtcatcta	gcattaggta	tatctcccaa	tgctatccct	cccccctccc	ccaaccccac	59940
cacagtcccc	agagtgtgat	attccccttc	ctgtgtccat	gtgatctcat	tgttcaattc	60000
ccacctatga	gtgagaatat	gcagtgtttg	gttttttgtt	cttgcgatag	tttactgaga	60060
atgatggttt	ccaatttcat	ccatgtccct	acaaaggaca	tgaactcatc	attttttaag	60120
gctgcatagt	attccatggt	gtatatgtgc	cacattttct	taatccagtc	tatcattgtt	60180
ggacatttgg	gttggttcca	agtctttgct	attgtgaata	gtgccgcaat	aaacatacgt	60240
gtgcatgtgt	ctttatagca	gcatgattta	tagtcctttg	ggtatatacc	cagtaatggg	60300
atggctgggt	caaatggtat	ttctagtttt	cttaatgaaa	cattctgaag	ccaactagca	60360
aatggtaatg	tctgcaggtg	gattttaatt	agaaaagtaa	aagagagatg	gaatttacaa	60420
atctcttcta	ccctaaacct	cccccacccc	agaaaaggac	cagacaaaag	ttttaattcc	60480
aaaaaccttg	catttaaaga	gtccttatgc	aacatagaga	gtaacaggat	ggttaccaga	60540
ggctgggaag	ggtagtaggg	gtcaggggaa	ggtggacaca	gttaacgggt	accaaaaaaa	60600
aaaaaataga	aggaatgaat	aagacctacc	atttgatagc	acaacagggt	gactataacc	60660
tgtgataaca	ggttattata	gtcaataata	acttaattgt	acatttttaa	ataactaaga	60720
gtgtaattag	attgtgtgta	atacaaagga	taaatgcttg	gggggatgga	taccccattc	60780
tccaagatgt	gattattacg	tattgcatgc	ctgtaccaaa	acatcccatg	taccccataa	60840
atatatacac	ctactatgta	ccctcaaaaa	ttaaaaaata	aagagtcccc	atacaaaaga	60900
tataagtcac	agcatcctta	caagatagag	atcagtgaca	tgggcaagca	acctcacctc	60960
ttacaggggg	catgtaccat	ccttctatag	tgaagaagca	tttccgtaag	ttaaaattga	61020
gatgaatcat	atggtttcag	cccctagagt	atggtatttt	agattcaggt	ctaattccat	61080
agaaggaagc	ccttactttc	ttcaggaatg	aggcagtttg	ccatttacca	agcacgctgg	61140
ccccactcat	atccatttgg	aggacttcaa	atgttgatga	caagactaaa	gaccaggagc	61200
ctggaatttt	ttactttccg	caggtagaga	ctgtaaagca	cattgacggc	agactcctat	61260
aaactaagaa	acttgtaaac	tggtacctgg	aaggcaatta	ggcagaagtt	atcaagaact	61320
ttatcaaaag	tgcatcctct	ctgacctaac	aattgcactt	cctggaatgt	caactaagaa	61380
catgtgcaaa	gatttagctt	tttaaaaagt	gattcacgct	attatttata	ataatgaaaa	61440
accagaaaaa	gccttaatgg	cccaacactg	gttgagcata	ctgtggtaca	cccactatta	61500
tacaggataa	tagcaggata	cagtagtatg	catcattata	aatgatgtag	aaatacattt	61560
attgacattg	aaacatattt	acaatacact	attctgtgaa	aaaagcaagt	tataaaacag	61620
tatgtgcagt	gtaaactcat	cattgttaat	agacagcaat	aaagatatgc	agaagaaaaa	61680
actctgaaaa	tgtacgcaga	aaaatgttta	tcagtggtgg	gaaaatgagt	ggttgttttc	61740
ttttttaaaa	ttatctgtat	tttctgattt	tttccccttc	aatgaacata	taattagaaa	61800
tacttgtata	cttagagatg	gttctaaaaa	taagcaacca	aacagtaaat	tgccttatgt	61860
tcaaaggggc	tcccacatct	gcactcccgc	tctcatatcc	gctaagcatt	tttttcctca	61920
agggagtgac	cacctgccag	ggcctcagaa	gatgcctaga	gacaacgtct	ttcctcactc	61980
ccaagccact	ccagccctgc	tgcctccaag	gtcaggttca	gcgcaagagt	aggctcagaa	62040
acaactccga	gccagtccct	gggtcgctgc	cccagaattt	aagcccatcc	ttcaatttcc	62100
tcagcagtca	aatatccctg	gtcacttacc	tctcccgagg	gcagcgcccc	gcgcttgacc	62160
tcctcgtaag	cgcctacctg	ctcccaggtg	gccaggaagg	cgtgggtggg	ggtaaagcgc	62220
gcagagcgcg	ggaagccagc	gcgcacatag	cgggcggcca	ggcccagcac	tgcgggggag	62280
gtgtcctctc	ggtacaggac	tcggcctctg	ccgtggctcg	tgtcgatgtc	cgccagaaaa	62340
ggggcgatgg	ccgggaagtc	ggtggggaaa	tcatagtcca	catactgcgt	ttccctgggg	62400
aagtcctgag	tggagatgat	gccgttggtg	cccacctggg	agaggagagg	gacaaaaagg	62460
tgacagtcgc	tcaagcccaa	ggacgctacc	ctttcgcgca	gggagggaag	ggaactgact	62520
taggcaaaaa	gcctctctct	ccttccccac	tggccaggga	gtctggattc	agggaaacaa	62580
gcgcaacttt	tgcgactgtc	ccagctccgc	gctgcagtag	gtccaggggc	cctaaaactc	62640
gttcacctat	cttctcactc	ccctcacaac	cccggagccc	catgtcctcg	gagaggaagc	62700
ctccaggtct	gaagagggaa	caccccagct	ccgcagacgg	gcacagcctt	ctcgcggtcc	62760
taactgcaaa	gcccgctggc	cgccctagca	acgccacctt	ttccgcctgg	gacgcttacg	62820
tggctgcgaa	caattcttgc	tctcccctcc	aggtcattct	tgctccccta	cagcagcggg	62880
gcaggcagcg	gcatcgctct	ctggccgggt	accaccgcaa	gggtgctggg	gggctccagg	62940
agtggggtct	gtttcctccc	ctctggaggc	agggtttccg	tgagaccgac	cccagggaag	63000
aagctgcggg	aaaagtgcca	ggagggggct	gaacttacgt	agaggttgct	gaatcgggct	63060
tcgtagaagt	gcaggggatt	cgccagcttc	accacggctg	agctttcgtc	gtcgccttcc	63120
tgcaggagct	ggtcccccca	cgactccccg	tgtgggaaga	gctcgtctgg	gtgcagcgcc	63180
gcggcccgca	acattagcaa	cggcagcagc	agtagcactg	gtaacgacga	cagcaccggc	63240
cgcccggcca	cccggtcccc	ctccat				63266

Following is an ENDO180 genomic nucleotide sequence (SEQ ID NO: 3).

>17:61200451-61268650
1	catattgtgc	tgtgcttcaa	atgtgtctca	tgtctcctat	gcagcgtgtc	acagtgtcat
61	ttgacatcaa	tcatgttggc	agggcagcag	accccccccg	ccccaccgat	acatacattt
121	tttgttttgt	tttattttga	aatagataca	gccttcttgt	cattcttttt	tttttttaat
181	tttttttaaa	atttttttga	gacaagagtg	tcgctctatt	gctKaggttg	gagtggcact
241	atctcggctc	actgcaacct	ccgcctccag	ggttcaagtg	attctcctgc	ctcagcctcc
301	tgagtagctg	ggactacagg	cacccgccac	cacacccggc	taagttttgt	atttttagta
361	gagacggtgt	ctcaccatgt	tggccaggct	ggcctcgaac	tcttggcctc	aagtgatctg
421	cctgcctctg	cctcccaaaa	tgctgggatc	acaggcatga	gccaccatgc	ttggccgtca
481	ttcttaatag	acaccaggat	actgaaaaat	gctttgccac	tcagaaaaac	aagggtacaa
541	gcatgatact	atatggccac	tctcattcca	cttcagtgtg	tgtgtatggt	gggggcacaa
601	aagggatggg	tggagactgt	ggcaaaccgg	tgagcccaca	cccctcccag	gtgggcagct
661	gcaccagctc	ttgtggctgg	caccctgcag	gcatgctgcc	tcgactggaa	atctacattt
721	ttatgtgtaa	tctctctcac	acatcctgaa	gccaaacaca	acttgcctgt	gggctatcat
781	ctaaaattcg	gaggctagct	ggagtccgct	ctggaataag	tctgcctggc	catccttccc
841	agctcttccc	cttattaact	gtgttatcaa	gatgttaatc	tctcagttat	ttaatacctc
901	agtttcctca	tctgtcaagt	gcagatcaga	attttgccta	catctgaggg	ttgttataag
961	gattaatgaa	aagccttgga	acccactgtc	tggtgcctgg	acgcgcatgg	ttaatgcctg
1021	gcattctttg	tgtctctttt	tacaagcgca	gggtgaccac	aggtcccagt	ttgccggggg
1081	caggcctggt	tcatgcttgt	ggtgctggtg	taatgatcac	taacttgcca	tttcattgtc
1141	ggtattgacg	taaatgatat	gatttgccta	gagaagcaaa	tactggcaca	gtgctgttta
1201	ggactctgat	gaggtttaga	cctaatagaa	aggccatggt	ccaggttcct	tgaacatccc
1261	tggacaagtc	acttaacctt	tctgtgttca	gtttcccgtt	ctaaacgatt	ggcaagatga
1321	attctaagat	ccctccattc	acagtcattc	tgtcatttga	caaacatctt	tttttttttt
1381	tttttaaacg	cagtctcgct	ctgtcgccag	gctggagtgc	agtagtgcga	tctcggctca
1441	ctgcaacctc	cgcctcctgg	gttcaagcaa	ttcttctgcc	tcagcctccc	aagtagctgg
1501	gactacaggc	gaacgccacc	acgcccagca	aatttttgta	cttttagtag	agacagggtt
1561	tcaccatgtt	ggccagaatg	gtctctatct	cttgacctcg	tgatccaccc	acctcggcct
1621	cccagagtgc	tgggattaca	ggcgtgagcc	actgcgcccg	gccgacaaac	atctttcaca
1681	agctcagact	catgccaggc	aaaggtccag	ggcatggaga	agccaggggc	agagcctggg
1741	tcctcagtgg	gcacttggcc	agtgaaaacc	tccagtgcag	gttgttggga	atctctacct
1801	tttttgtcaa	gtgttacttg	aaagaccatt	accaagaaat	tgaattgaaa	gttaattttt
1861	ttctccttct	ttaYggagac	gagtttcact	ctgtccccca	ggctagagtg	cagtggtgcg
1921	atctgggctc	actgtaacct	cctcctcccg	ggttcaagca	attctcctgc	ctcagtctcc
1981	tcaggcatac	accaccacat	ctgccaccat	acccagctaa	tttttgtatt	tttattagag
2041	atggagtttc	accatgttgg	ccaggctggt	ctcaaactcc	tggccttaag	tgatccacct
2101	gcctcggcct	cccaaaatgc	tggaattaaa	ggcgtgagcc	accgcgccct	gcctgactgt
2161	taatatttta	aacctcagtt	tctcaggaac	taatcattct	ggttgaatac	atttYgctac
2221	acatttcttt	tgtttgtggg	ggggtatcta	agttgttttt	ttcttttaag	tcagaaaaca
2281	taaattttca	ctatggaaaa	ttgtaaatta	cagaaaggcc	caaagatttt	cttcatttct
2341	gctgactctt	caatgaacca	gaggggcacg	tgtaatattt	ccgctttcgg	ttactcccca
2401	ccccacacac	cttgtagaca	ctttgtcaaa	actacatttt	aaaaaaatgc	tttcccccaa
2461	attcgtatgg	atgtctccta	ataaagtcac	gcagtcactc	actggttcgt	cctcaatcaa
2521	ccaggcgtgg	agtcctaacc	tgtccatgat	tttaagaaag	ggcaggcgca	caacaccccc
2581	gcacggagaa	atgaacaggt	gtggctcggc	agaggccttc	cgcacctgcg	ttatggagtg
2641	gtggccgctg	tcggcgatgg	ggtccccgcg	agggcacaag	tgatcgcgtg	gccacggcga
2701	ggctctgcct	ccgcccccgc	gctccgggtc	ccattcccga	attctgccct	cagcggcctg
2761	gtcaatgagg	ttggatcgtt	ggcccagaaa	gccacttcct	gccgcgactg	gagccagccg
2821	tcgttgtgaa	aattcccccc	acggggaagg	aagtggctct	tgggctgttt	attttggctg
2881	cgggctagca	gacggcgcca	ggggcagcgg	ccacgcagac	cgggcatttg	tctagctggg
2941	cgggaggcgg	cggagcggga	agtgccacag	attgaggggc	gcacggcggt	ggagggaggg
3001	gcgcccagtg	gagagggggc	tcacggtgac	agaggaagtg	gcgccgcttg	ggggggtgca
3061	cgatggcagg	gggaggggtg	ctcggtggag	ggaggggcac	acggtggcgg	ggggaggggc
3121	gtgccgcaga	ttgagggcga	acggtggctt	ggggaggggc	gctccttgga	gttgggggcg
3181	cacgatggcg	ggggcagggg	tgccccttgg	gagcagaagc	agagaagact	cggaactcca
3241	agagcaggtg	gatctgggag	ccccagatcc	tgggcactgg	gttgggggag	aaaggggtca
3301	aggtgtgccc	gcccccggga	tgctcggact	ctggggatcc	aggcctggtg	acccccggtg
3361	aggaagagcc	agtgggagga	aagggccggg	cgctgcccgg	agcagaggct	ggaggcgaga
3421	gcgattgctg	cttgctgtag	cgcggccgct	ctccagttcc	tccggcaagg	ggggcctggg
3481	ggaggactgg	ccgaaaatac	tgtgatgctt	tggtctaaga	caaaagccag	caggggatga
3541	gatcaaacac	catgacactg	cgaaggggaa	ggccagcgcg	ggtgaggatt	tgccttccca
3601	gagaacccca	ggggcggggc	tagcttccac	tcagcccgca	ttacccccac	ccccgccccc
3661	acccccgggg	cggggtctgg	aggatcagca	aaaccgcggg	aaaggtgaca	gtcgccttcc
3721	ccaccaccgc	ctgcatttag	taggtggagg	gacagtccca	cctctccacc	cattccctgc
3781	cagagtgtga	tttaatgtct	tcctagaaca	caggatatca	cagtctgcag	cacagagatt
3841	tgaagtgggg	agaaaagcat	ctctggaaat	gactggtggg	ggaagcccgc	cactgctcta
3901	caaagggtgg	cctgtgacag	caacagcgca	acactgggac	tgtgtgtgta	ggttttaggc
3961	acaagcactt	taagctgtgg	gaggaaagca	gtttggcctg	gctgggatgg	aggggctgtt
4021	ggggaggagg	gaggagggtg	tgaaaagggg	aaggtggccg	gtagagggaa	acccaccatg
4081	gttcaggatg	tcggtgggga	tgttgcacag	ttgggcgggg	tattgggctt	cgatatcatg
4141	taacccccgt	cctccatgga	agcaatgccc	ccctcgtcca	gcccaggatc	taatgtgcat
4201	gcatgtacgt	ggacacagtc	tctagccagg	ggtggtgcag	ggtggggtgc	tgggtcccca
4261	gggttggcct	cttagcaggg	tggggctggc	agcttctgct	gactcaagga	catttccagg
4321	cctggcctgg	aggttaagca	gctcattgaa	aacagctgct	cctcttggct	ggcggccctt
4381	tcaggcggcc	tctggctctc	cctgggatga	cccctcgcct	ctgcgtggcc	tggggagggg
4441	cagtgaaggg	agagaggctc	agaggctgga	ggccaccctg	ccatgccctc	agggatggaa
4501	ctgagtcccc	tccagggctg	gccagctgtc	ctccagcccc	cagctttcca	ggagctaagc
4561	caggtggtcg	ctgggccctg	cgttcctgcc	tgcagccttt	gctcctgcgg	ttgggcagct
4621	tggaccgcct	tccttgtcct	tggaatgcct	tccttgtcct	tgtctctgct	tgtgcctttc
4681	agggttttat	gtgacatgcc	tctcattcaa	cacatatttg	ttgagagtcc	gctgcatgcc
4741	aggcaccatg	ctagaattaa	cttctcatct	gcctccttca	tctgtgatgt	cttgtggaga
4801	gcagccgtct	tatctgaggt	cagacctctg	gctgcctctg	tggatgggct	gagtccgggg
4861	aaactgcagc	aacagctgag	ggttttgctc	cagagacaca	aactgttgtc	aagcctttgc
4921	actcagcctc	gcgacttcac	caaagcattg	tgtgccttga	agcagacagg	acgggagagg
4981	aggcctcagt	gaccatcaag	gaggaaggag	atgggttact	caatgtaggg	caaattgctt
5041	taaaacccag	ttgcccatga	gcacaggcat	gtttcccagg	tgatgacctg	gatgtctgag
5101	aaacaagaag	tgtggactac	atcagaaata	ttcctatcaa	actagacacg	gtggctcaca
5161	cctagaaatc	ctgcactttg	gaaggccaag	gtaggaggat	caggaggttg	gggccaggag
5221	ttcaagatca	gcttgggcaa	caaagcaaga	ctccgtctct	acaaaaagta	aaaacaatta
5281	gctggggctg	cgtgcggtgg	ctcacacctg	taatcccagc	actttgggag	gccgaggcag
5341	gcggatcacg	aggtcaggag	atcgagacca	tcctggctaa	tgcggtgaaa	ccctgtctct
5401	actataaata	caaaaaaatt	agccgggcgt	ggtggcgggc	gcctgtagtc	ccagctactc
5461	gggaggctga	ggcaggagaa	tggcatgaac	cccaggggtg	gagcctgcag	tgagtggaga
5521	tcgctccact	gcactccagg	ctgggcaaca	gagcagactc	cgtctcaaac	acaaacactt
5581	tgggaggcca	aggtgggtag	atcacgaggt	caggagattg	agaccatcct	ggctaacatg
5641	gtgaaacccc	gtttctacta	aaaatacaaa	aaaattagcc	gggcatggtg	gcgggcgcct
5701	gtagtcccag	ctactcggga	ggctgaggca	ggagaatggt	gtgaaccctg	gaggaggagc
5761	ttgcagtgag	ccgagatcgc	gccactgcac	tccagcctgg	gcaacagagc	gagactccat
5821	ctcaaaacaa	acaaacaaac	aaacaacaat	tagctgggca	tggtggggtg	catgcctata
5881	gtcccagtta	ttctgggggc	ttaggtggga	ggatcacttg	agcccaggaa	ttcaaggctg
5941	cagtgagcta	tgatcatgcc	actgcactcc	agcctggaca	acagaacgaa	actctgtctc
6001	tttaaaaaaa	aaaaaaaaaa	gaaaaagaaa	agaaaaaaag	aaagaaagaa	atatttctat
6061	cacacttcat	ttatctggaa	agttcatttc	tatctatcac	cttcaccccc	aaccgtgcag
6121	acttaaactt	ttccatggat	tgcttcatga	gttcagcctc	tccagcttca	ttataaacgc
6181	atgagggcag	aggctgtatc	ttcttttgat	tcctaggctg	gaatgcagtg	gcgtgattat
6241	agctcactac	tgcctcagac	tcctcggctc	agttattcct	cctgcctcag	actcccgagt
6301	agctgggacc	acaggcacat	gccaccacac	ctggctaatt	tttttttgag	atggaacatc
6361	actctgttgc	caggttggag	tacagtggtg	caatctcagc	tcactgcaac	ctccgcctcc
6421	tgggttcaag	cgattctcct	acctcagcct	cctgagtagt	tgggattaca	ggtgtgcgcc
6481	accatgcccc	gctaattttt	gtacttttag	tagagatgga	gtttcaccat	gttggccagg
6541	ctggtctcaa	actcctgacc	tcgtgattca	cccgcctcgg	cctcccaaag	tgctgggatt
6601	acaggtgtga	gccaccacgc	ccagcctaca	cctggctaat	ttttaaattt	ttttgtagag
6661	acgggatctc	accatgttac	ctaggcttgt	cttgaactcc	tgggctcaaa	cgatcttccc
6721	accttagcct	ttcaaagtgc	agggattaca	ggcatgagcc	actgtgccca	gcatctggtt
6781	catttttaat	ttcccttaca	gtgcttcata	aatgattatc	atctgtatgg	gataagaaag
6841	cccccaaggg	agcagccaga	aggatgatta	ggagaatggg	ctgagggtcc	agcctccagg
6901	cacctcctct	gacatggcct	tggtgctgca	gccgacccaa	gaggctggtc	tgacaggtca
6961	gaggaggtcc	tagagcagta	acctcccagg	aaataaggag	aatgggacag	aaacccaatg
7021	cagacaagct	aattaaaaaa	ggaatgcagg	agcccagctg	gctgcagatg	atcctgagtg
7081	tttcacagaa	tggaggaaag	agcctcaggg	attcagggac	aggacatcca	gcatctttgg
7141	gactcacttc	ctctctttcc	atctctttgt	cccgtttcac	tctgcttctc	tttatatatt
7201	atcccctcat	cgtaggaagc	atggccattg	gcagccccag	cctagcaatc	ttaacaaaaa
7261	gggaaagctt	tatgtgttcc	aggggagttc	tctgatcagc	cctgtttgag	ttatgtgccc
7321	catcactgtg	gccaagggga	tagacactgt	catcagctca	agagtgagcc	ttgtgcccac
7381	ccacacatcc	acatagccag	aggtacacaa	tacaaggaga	acaagaaggg	gatgggaagt
7441	ttcctgggca	gataaaggca	gctcaatgag	gtcacagatt	gttatcgttg	ccatgtcttc
7501	attgtagagc	ccagcgccct	gccagaccat	atggtgataa	gggctgggat	catgtctata
7561	ttgttcacaa	taccctcagt	gcctRatgcc	ctgctggcat	ctatgaaatt	ctcaatacat
7621	cattgttgga	tgaatgaatg	aataaatgaa	tgaatcacac	ccagccagtg	ctcagtgcac
7681	agctccctgc	ctagcttcat	tcatttctcc	atttactcag	taagaacata	ttgagccaca
7741	gcttgatgcg	tagcactgtg	ctaggcatgg	gttgattgcc	tacaaaatgc	aagaagtggt
7801	ctttgtcctt	ggggaggaga	atcccaagat	ccttgtgagg	ggccctgcac	cttctgtggg
7861	gggcactttt	gctccctgca	ctgacacctg	atgctcccat	gcatatggat	gaggctgggg
7921	ggtgggtgag	gctggagggg	ccctctctgg	atgggggtgg	ggggcatcag	gcctctgcac
7981	tctgagctcc	ctctgcccgc	tttgtatgtg	cttgatgaag	cacgSgtaca	aagaacacag
8041	agccagctct	caggacgcct	tttctctttc	cccagcagtt	ccagcccagc	ctgagcgtgc
8101	actccccctc	cactaggcct	tggagaaaga	gcctcttttc	attgagggcc	caggcccacc
8161	ggccacttcg	ggtggaaaat	gctctcaaga	accccctgac	cccggcttgg	cagagtcccc
8221	ccggatccac	ctacaggaat	cccccctcag	cttctccttt	gctttgcaga	gctcctgcac
8281	gcctctcctc	tgctttttga	ttcctcagcc	ttttctcatt	tgctgccaaa	tgagaaaatg
8341	caagaggttg	cctttgtcct	cttttgctgc	caaatgagaa	aatgtgacct	gtgttcttca
8401	gtgcctcctc	cacattgcag	tcttcagatc	tctgcccagc	ggagtctctc	ggcccttggg
8461	aggcacagag	ctccttgtaa	cgcccccaga	cacctgggat	tttaaaggtt	tgtttgctct
8521	tatgcccggc	atttctcctc	taactggatt	acaaatcctg	cgaggggagg	gacggtgctg
8581	cgagtttcct	tgtggtccca	gcattgcctg	gaacatgcca	tgcacctagc	agaaagttgg
8641	gtggatttga	acccagagcc	taggatgtca	gagggaggag	gggcctYgaa	gctgtgcctc
8701	atgtgacaaa	ggaggaaact	gaggcctgaa	aggtacttct	gttggacatt	ctaatcccgt
8761	cccctttctg	gacttcagtt	tcctctgtca	agtgagggga	ggttggcctg	accctgggaa
8821	aagcccctcc	cgactaacct	ggacctcttt	cagacccttc	attcaccgtt	tgctacaact
8881	gctacagccc	acctggcatt	gatttagcac	acttgtggat	tttctggctg	gggaggagag
8941	gaagataacg	tcctcttggg	ctattgtggg	ctcacgtgaa	gttttgggct	tcgttttcca
9001	gtcgtatctc	tgagaaacat	ctacaaaaca	agcaataatt	tttttccttt	tccggcccca
9061	ggcccctttg	gctacctcct	gccaaggcca	ttttctgtta	ctactgcctg	gagtagagtt
9121	tctgagaacc	agatacctac	tccttaaagg	aagcttgggc	aggcatggat	caagtcctgg
9181	agctggtttc	tggtttctgg	tgggtggctg	aaaggtgacc	tagtctgttt	gggttgttat
9241	aacacaatac	cgttaacaga	tggcttgtaa	acaatagaaa	tgtatttctc	atggctttgg
9301	aggctgagaa	gtctaagatc	aaggttcctg	ccgattcaat	gtctggtgag	ggccacttcc
9361	tcgtggacag	ctgtcttctc	actgtaccct	cacatggtgg	aataggtgag	ggtctctctg
9421	gggtgtcttt	tattaggacg	ctcatcctat	ccatgaaggc	tcttccctaa	tgacctaagc
9481	acctcccaaa	ggtctcacat	cctaatgcca	tcaccatggg	ggtttaagat	ttcaacacag
9541	gccgggcgtg	gtggctcact	cttgtaatcc	tagtactctg	ggaggccaag	gtgggaggct
9601	cacctgaggt	caggagtttg	agaccagcct	ggccaacatg	gtgaaactgc	gtctgtacta
9661	aaaatacaaa	aattagctga	gcatggtgac	gcaggcctgt	agttccagct	acttgggagg
9721	ctgctgaggc	agaagaatcg	cttgaaccgg	ggaggcggag	gttgcagcag	tgagcagaga
9781	tcgcgccact	gcactccagc	tggggcaaca	gagcgagact	ctgtatcaaa	aaaaaaaaaa
9841	aagctttcag	cacatgaatt	tttggaggtt	gacacattct	gttcatggca	ggagggaagg
9901	agcaggttca	aggcagggga	cccagagatt	agctgtggca	gttgtcctag	gggtacttta
9961	ggaagctcac	tttgtcctgc	ccagagagga	accccatcca	agtgctgtta	gaggacagag
10021	gggcagggtc	cctgccccaa	cctacattcc	catggtggtg	ttttgagcat	cagtgacagg
10081	agctgtgggt	actatgtttt	aggaaaatta	atctggctgt	tggaacaagg	agcagaaaga
10141	taggctggtt	gtttgtgatt	attatctagg	catgaaattc	gttcattcat	gcatgtgttc
10201	atttgttcct	tcagtattta	agcatcactg	tgtgtcaggc	agaactgtag	gtgctggggt
10261	tacagtggtg	gagaagacag	aaaacaagag	tgtcagatag	cgagttctgg	ttctggaagt
10321	ggcagagtag	cttgtgtcag	tctaactctc	tggccaagaa	tgcttttaga	ctaagggaaa
10381	attataaaat	atggtgatta	tggtgatttg	aaggcaatga	acagcaatta	aaaccagaca
10441	gaggtagaga	ggaaaaaatc	cttgaaagta	aaaagtaaac	ctggcacatt	taaccagctt
10501	ttccctgaac	acactacctg	gtttgaggag	ctcatacaga	aagtggcagt	tttaccggtt
10561	agagcttggg	gccactagaa	aggctaacat	tgagaggaaa	tgttaggaaa	gcaaggagcc
10621	atagaaattc	cttctacaga	ttctccttaa	atccttggtg	actcctgaac	tgtgcatttg
10681	cagggtaggg	ttctaagcag	cccagcaaga	aacagcagct	gggaggtaga	ggtttcagtt
10741	gctatctggt	gctgaggaaa	cagagtttaa	aatttaagtt	ccaccaagtt	tgaggggctt
10801	agtaatcacc	taaggttttc	ttttgaaatc	ccagaagggc	ctcaccttat	gattaaatcc
10861	aaggttaaga	gccacatctg	aagactaaag	gcaaaactca	aacaacccca	ccctagcaaa
10921	gcttaaaacc	aaacctccac	aagagcaagg	taatccactg	gtaatttaac	tgcctgccat
10981	aacaaaatcc	agcattcttt	agaggaagat	ttttttaaaa	tccagattcc	ctttaacata
11041	gcatccctga	cgttcagtat	acaacaaaaa	agtccagact	ccttatgaca	ttatccacaa
11101	tgtccagcat	ataataaaaa	tttgcagata	gtaggcagca	ggagatgacc	cataatcaaa
11161	agaaaaaaca	gtcaatagat	gcagatgcac	agacaaccca	gatggtgaaa	aaaatcagat
11221	aataaatgcc	atgaagagca	ttataatcaa	gtgatatgat	agagagtaac	tgtggtcact
11281	ttacgattgg	gaggccagga	ggatctctct	aaagatgtta	cccttttttg	ttgtttgaaa
11341	tgtgaaatgc	caggtagagg	aaataatgca	taggcccaga	gataggaaac	agccaggctt
11401	gttcaaggaa	gaacaaggag	gtcaaagcga	cttgagcaag	gtggagtaac	aagatttgag
11461	atcaggccgt	tagacaggac	cagatcatgt	taaattgtgg	ctcatagtaa	gaggctgaat
11521	ctcatttgaa	gaatgatgaa	ttatctttga	agtaattcaa	gcaggaggaa	gacttacctg
11581	ccttctgttg	ttgttgtttt	tttccctttt	actatgagcg	aggctgtcat	ttcaaatatt
11641	taagaggcaa	ttgcattttc	ttcttttgct	gtctatgcat	atctcttctt	cattttctac
11701	tgcattgttg	atactttccc	taagtttcat	gtatctattt	ttttggtaga	agctcttctt
11761	tcttttcttt	tctttccttc	cttcctttct	ttcttttctt	tctttctttc	tctttctttt
11821	tctttctttc	tctttctttc	tttctccttc	cttccttcat	tccttccttc	cttccttcct
11881	tccttccttc	cttccttctt	tcttaagact	agtaaagtca	gaaaggagga	aagagtagaa
11941	caaagacttt	ggtctgtaac	tgactatgaa	caaccaattg	agataactca	ccatctttgg
12001	accagccaga	ggctctttta	atattgtgga	cttaactatt	tgcctctaat	aaggcacata
12061	tatttttgtc	atttatttga	attttgacct	tgctgatggc	atcatatgtt	ggcattaaaa
12121	aaatcttttt	atgggaaaaa	agttcttatg	ctattgaatt	catcagtgtt	gtctatgacc
12181	ttcaacattc	caataatatt	tttaaatttt	ttctaggact	gatttatatc	tttaaaagat
12241	tattctaggc	caggtgcggt	ggctcatgcc	tgtaatccta	gcactttggg	agtctgagga
12301	gggcagattc	cctgagctca	ggagtttgag	atcagactgg	gcaacatgga	gaaacactgt
12361	ctctactaaa	aatacaaaaa	aattagccag	gcatggtggc	atgtgcctgt	agtcccagct
12421	actcgggagg	ctgagacaga	agaatcgctt	gaacctggga	ggcagaagtt	gcagtgagcc
12481	aagattgcgc	cactgcactc	tagcctgggt	gacagagcgg	gactctgtct	caaaaaaaaa
12541	aaaaatagat	tattctgact	gtctttggag	aatggactat	aataggatga	tgagatcagc
12601	atSggggaag	agagagaact	tgagatttgg	acccaggaga	tgagggccac	atttcagctc
12661	cttcccttaa	caatcttacg	actcttgtca	tcaaattgct	tcaccaccct	cagccaattt
12721	ctttaccaat	aacatagcat	aatgctgatt	tatagtcttc	ttactgtgcc	agatcctgtt
12781	ccaaatgctt	tacatgtatt	atctcatttc	atcgttacca	gagtcttaag	atgaggaaac
12841	ggcatagaga	gatgaagcac	tttgcccaag	tcccatattc	agtggcagac	ctagaatcga
12901	agcactagct	gccgggcacg	gtggctcatg	cctgtaatcc	cagcactttg	ggagaccaag
12961	gtgggcggat	cacccgaggt	tgggagtttg	agaccaccct	gaccaacatg	gagaaatctc
13021	atctctacta	aaaatacaaa	aaaattagcc	aggtgtggtg	gtgcatgcct	gtaatcccag
13081	ctactcagga	ggctgaggca	gaattgcttg	aacccaggag	gcagaggttg	cagtgagccg
13141	agatcgagcc	attgcactcc	agcctgggca	acacgagcaa	tagtccgtct	caaaaaagaa
13201	acaaaaaaaa	gaaacaaaag	aaaataaaca	ctagcagtcg	gattcatcat	ttcaacacat
13261	gaaaagtatc	ctggggagct	agtggctagt	ggatgcaaaa	gttctttgga	gattggatgt
13321	actccatatg	tgtgttgtgt	acataagtgg	cagtcaggga	acaagaggaa	ggtgatggat
13381	gtcacagaga	tctgggtttg	cttactgggc	gtgggacact	gggagtaggt	cacttcatgt
13441	ctctaagact	ctgtctgtct	tttcttacct	tccttccctc	cctccctccc	tccctcattc
13501	cctccttcct	accatccatc	cctccctccc	tccttcctcc	ctagtttctt	cctttctttc
13561	tctttcctcc	ttcctaccct	cccttgctcc	ttcctttctt	tttcttcact	gaaacataac
13621	tcacatatag	aatttaccca	tttaaaacat	atatttaatt	gggatttagt	tttttcacag
13681	cattgtgcaa	ctatcatgac	aatctaattt	tagaacattt	tcgtcatatc	cccaaaagaa
13741	gcaccgtgcc	ctttagcagc	cactcccctt	tctcgtcacc	cacaggcaac	cattaatttg
13801	ctttctgtct	ctatgcattg	aagcttcatt	tcttactctg	taaagtgggt	gtgctgtggt
13861	ggggggcagg	ttggatttcc	cccaRtgact	tctacagagg	gtgcctgctc	agcgaggaga
13921	taggtggaaa	gaggaaaggt	tgaggaagcc	aaagaattaa	attgctgcgt	aaaaattaag
13981	gcgtgaaata	gttcaggggt	gggatgagtg	gtctgggaag	atcctagaag	aaggaaagga
14041	tggaaccagt	gcaaggggca	gggggaaggg	tgagacacaa	tgcctccgga	tcaaaggaga
14101	attttggcag	aaaaaccacg	ccatgtaata	gagattgaga	ttgaggttgc	aacgtggtgt
14161	gtggtgtaaa	tgcctccact	cctcctcata	aaatcttcag	aaaagtatac	aggtgatgtg
14221	ccgggtggag	ttgggtttgc	tttttttttt	tttttttttg	agacggagtc	tcgctctgtc
14281	gcccaggctg	gagtgcagtg	gcgggatctc	ggctcactgc	aagctccgcc	tcccgggttc
14341	acgccattct	cctgcctcag	cctcccaagt	agctgggact	acaggcgccc	gccactacgc
14401	ccggctaatt	ttttgtattt	ttagtagaga	cggggtttca	ccgttttagc	cgggatggtc
14461	tcgatctcct	gacctcgtga	tccgcccgcc	tcggcctccc	aaagtgctgg	gattacaggc
14521	gtgagccacc	gcgcccggcc	tgggtttgct	tttgagggtg	gtacagagga	ctgagtcctc
14581	cctcctggtg	agcaggggct	agaacagagg	tagtcctgca	ggcctctgcc	tcatctgggc
14641	acaagggctt	agcactgcca	ctcatttcca	cctcagaggg	ttggtagtga	gtaccgagtg
14701	atttaacgta	tgagtgacgg	ctcaccatcc	tgcactgggc	acatggtagg	tgcctgtcag
14761	ccacaccggt	catcaagggc	caaccaggag	agcccctgtg	atgccttcgt	gtcttgcctt
14821	cccttccaga	acccaacRtc	ttcctcatct	tcagccatgg	actgcagggc	tgcctggagg
14881	cccagggcgg	gcaggtcaga	gtcaccccgg	cttgcaatac	cagcctccct	gcccagcgct
14941	ggaagtgggt	ctcccgaaac	cggctattca	acctgggtac	catgcagtgc	ctgggcacag
15001	gctggccagg	caccaacacc	acggcctccc	tgggcatgta	tgagtgtgac	cgggaagcac
15061	tgaatcttcg	ctggcattgt	cgtacactgg	gtgaccagct	gtccttgctc	ctgggggccc
15121	gcaccagcaa	catatccaag	cctggcaccc	ttgagcgtgg	tgaccagacc	cgcagtggcc
15181	agtggcgcat	ctacggcagc	gaggaggacc	tatgtgctct	gccctaccac	ggtgaggggc
15241	cgcttgcagg	cgggagggtg	gggtccccKa	tgtccagggg	actggagcca	tgagggacag
15301	attcccagtg	acaaggcctt	tggcctctgt	ggacccttgg	cagtcacatg	tttaattata
15361	ataggaagca	ttttttaata	attaagaaaa	ttaacttcag	gccaggtgcg	gtggctcacg
15421	cctgtaatcc	cagcactttg	ggaggccaag	gtgggtggat	cacttgaggt	caggagttca
15481	agaccagcct	ggccaacatg	gaaaaacccc	atctctacta	aaaattcaaa	aattagccag
15541	gtgtggtgga	gcatgcccat	catagtccca	gctacttggg	aggctgagga	aggagaatcg
15601	cttgaaccca	ggaggcagag	gttgcactga	gctgagattg	cgccactgca	ctgtgcagcc
15661	tgggtgacag	agcaagactc	tgtccccccc	cccacaaaaa	aaaaaagaaa	agaaaagaaa
15721	aaagaaaaat	taacttcaaa	gcatttaatt	tacttttgta	aaaattgcaa	aatacatgct
15781	tgtaaagtct	tcaaatagta	tacaagtata	taacataaaa	ttaaatgaaa	attcccttcc
15841	cccaggccca	ctctccaggt	gaaaccccat	tgtagccccc	catgttgtct	taatgcctgt
15901	cttgcatgtg	gtgaatgggg	accagagtca	ccatgtgagg	ggctggcctc	ttgtggtgga
15961	cagccccgtc	ctgggggggc	ctttcctggg	agaccccctg	agttccgaga	tagaactttg
16021	tggggacaca	gagcccatgg	gctgggtagc	tgagcagaga	ttccaccggg	ctcagccctc
16081	tgtgggtgac	ttggaggccc	tcttgcccag	ctggagtttg	gatgggatta	ggggtactag
16141	ggagcccctt	cccagcccta	tgaggtgtgc	agcaagacct	ctctctggtt	cctgggctga
16201	ctcaacagca	gaagaagcct	taaagccact	atggggtgcc	attgcctctc	ccacctgctg
16261	atccctgtga	acacccagca	ctctgggttt	taggggattt	ctcctgaggg	tcgaggggct
16321	tggcagcctc	tggtgtccag	atgccaaggg	cctggcccct	gtccaccccc	tgcagaggtc
16381	tacaccatcc	agggaaactc	ccacggaaag	ccgtgcacca	tccccttcaa	atatgacaac
16441	cagtggttcc	acggctgcac	cagcacgggc	cgcgaggatg	gtcacctgtg	gtgtgccacc
16501	acccaggact	acggcaaaga	cgagcgctgg	ggcttctgcc	ccatcaagag	tgagagctgt
16561	tggagccgtg	ggggcggggg	cagtgttcct	ggagggaggc	tggtgctgag	gggccccggg
16621	gcccagggtg	agatactgcc	ccctccccta	cctagtgtag	ccttttggtg	ggggagggtc
16681	tgcactcccg	agggaccctg	gagggggcct	gaaggagagg	gctgtcRtgg	tggcaggtaa
16741	cgactgcgag	accttctggg	acaaggacca	gctgactgac	agctgctacc	agtttaactt
16801	ccagtccacg	ctgtcgtgga	gggaggcctg	ggccagctgc	gagcagcagg	gtgcggatct
16861	gctgagcatc	acggagatcc	acgagcagac	ctacatcaac	ggtgagccgg	ggcctgatgc
16921	ctgctcgtgc	ctctggaggg	cccgggccct	ttccgcttgt	gggttgggga	gagggcgatg
16981	gggagcgggg	gaggctgggg	ctggggatcc	cctgttcagt	gtccctcctt	gctgtcaggc
17041	ctcctcactg	ggtacagctc	caccctgtgg	atcggcttga	atgacttgga	cacgagcgga
17101	ggctggcagt	ggtcggacaa	ctcgcccctc	aagtacctca	actgggagag	tggtgaggca
17161	caaggttggg	ggcgcagggc	agcatagggg	ccccgcgggc	tcttggcctc	ccatggactc
17221	ctctcctcat	gtcctcctgc	agaggggcag	tgtgggtagg	ggaagcaccg	acctccaccc
17281	ccctccccag	actgcgcccc	cctagcccat	gtagggcggc	gctgccccag	gccgaaggtc
17341	ttggtgcata	tggactgggt	gccagcctcc	actcacctct	tcagccaccc	ctgtgggcag
17401	cgggcaccag	cgcacccagc	agcctggacg	gggaggccgg	ggcggggctg	gtactggtta
17461	ctgggtagaa	ggttcaaggc	gacgtgcacc	caggttagaa	agcgcggagg	accccgtggt
17521	ctggggcgga	gctggagctg	agcaccaggc	ttcccgaact	ggctcaggct	tccgagggag
17581	cagagggagg	taggaggttc	tgagcagggc	cccgggagcc	acggtgtgag	cttctctctc
17641	cgggggtgct	ggcgccctgc	cctccccaca	gaccagccgg	acaaccccag	tgaggagaac
17701	tgtggagtga	tccgcactga	gtcctcgggc	ggctggcaga	accgtgactg	cagcatcgcg
17761	ctgccctatg	tgtgcaagaa	gaagcccaac	gccacggccg	agcccacccc	tccaggtgag
17821	ccagggactg	tgccgcaggg	tggggagggg	ctcccagggc	cagggacaca	gccacagagc
17881	cgtggcaggc	ccagcctctc	ctccggttac	caccacagca	caaggggact	ctggatcctc
17941	tgactcttat	ttcattgttc	agttaaagtc	tgagcaaatt	ggaatatgtc	attaattcat
18001	ttggggaaca	tgtgctgaga	tctgtgttaa	atgctggcaa	tacccactgt	tacctcgtag
18061	agaccacagt	ctgctggagg	tgacagacat	ctcaatgcag	ttagactatc	ccaggtcatg
18121	agtgattata	gaaatatgga	tcagtgttag	aggagcatag	agaagaaact	gattcagctt
18181	ctgagagtta	aggaggggtt	tatggaaata	acatttgatt	tgggcctttc	aaattgagtc
18241	taagtttaaa	agatataaag	aggtgtgggg	gaagggcatt	cctggcagag	ggaagagcat
18301	atgcaaaggt	gtggaggcct	agaactacac	tgcagcttta	aggggtggtg	agtgatggcc
18361	gggcaccgtg	gctcacacct	ataatccYag	cactttggga	ggccaaggca	ggaggattgc
18421	ttgagctcag	tagttcaaga	ccagcctggg	caacatagcg	agaccctgtc	tctgcaaaat
18481	atttttaaaa	aattagctga	gtgtggtgat	gcacgcctgt	ctactaggga	ggtcgaggtg
18541	ggaggattgc	ttgagcctgc	aaggttgagg	ctgcagtgag	cctcgcttgc	accactgcac
18601	tccaacctgg	gcaacagagc	gagacgagac	cctgcctcaa	aaaataaata	aataaataaa
18661	taaataaatt	taaaaaaaaa	aagaaaaaag	aaagaaaaag	aaaaaaatgg	atggtgcctg
18721	ttgcagtttg	ggtggagtat	agattctaac	cacttcaagt	atggtcatcc	aaccagcagc
18781	acagcatccc	cRgagggctt	gttagaaatg	cacagtcagg	cccgccccag	agtaattgaa
18841	tcagaacctg	catttaacaa	gatcctcaga	tgattcatgt	gcagacacag	tttgggaagc
18901	cctggcttaa	agggcatggt	gaagaagagg	caggttgcag	ccagtctctg	cagggtcttg
18961	gctgctgggc	caagtttggg	tggggccagg	taggctgtgg	ggagcctttg	aagatgttta
19021	agccagggag	tgtctggttc	tcgtttgtga	tcatagagac	agctttaggg	gcctcgtgga
19081	ggagttgggg	caatggacag	ggtctgcttt	agggattctg	ccccttactg	ctgtgtggcc
19141	ctgggcaagc	agcttagtct	ctggggtgca	gagtcctcat	tgcaaatgga	gaatRaagcc
19201	accccccttg	caaggttgtt	gtgaggaagg	ctggagatct	ggcctggcac	gaaggagttt
19261	ttctgtagtt	ggctgtggat	gtttactgtg	gtgtaggttg	gaggggctgt	gcagtttcct
19321	gcgaagctgt	ggggtggtga	ggagactttt	acaaagaaaa	tatggcaaca	cacacacaca
19381	cacacacaca	cacacacaca	cacacacaac	actaactaca	gacagtaaag	agtttacaga
19441	gcaaaacttc	tgctcctgac	catggaagtc	ttgccaatga	tcgactcagg	actggttttt
19501	ttgtttgttt	gtttgagaca	gggtctcact	ctgtcaccca	ggctggagtg	tagtggtgcg
19561	atcttggctc	accacaacct	ctgcctccta	ggctcaagag	attctcgtgc	ctcagcctcc
19621	tgagtagctg	ggattacagg	cgggcatcac	tacttcccgg	ctaacttttg	tatttttagt
19681	agagacgggg	tttcaccatg	ttggccaggc	tggtcttgaa	ctcctgacct	caggtgatct
19741	gcccacctcg	gcctcccaaa	gtgctgggat	tacaggcgtg	agccaccgca	ccccgccttt
19801	ttatttttat	ttttatttat	ttattttttg	aaacagagtc	tcgctctgtc	gcccaggctg
19861	gagtgcagtg	gcacaatctc	cactcactgc	aacctccgcc	tcccaggttc	aagcgattct
19921	catcYccagg	ttcaagcgat	tctcatgcYc	cagcctcccg	agtagctggg	attataggca
19981	tgagtgtgcc	accacgcccg	gctaattttt	ttgtattttt	agagatgggg	tttcaccatg
20041	ttgcccaggc	tggtctcgaa	ctcctgtctt	caagtgattc	acccgcctcg	gcctcccaaa
20101	gtgctggaat	tacaggcgtg	agccacggct	ctggcctgat	tcaggactgc	tgaccactgc
20161	tttatctccc	attccgtaag	gggccaggag	cagaagcttg	aaacgtcagc	aacccgatct
20221	agggcacctc	cacctctagc	tggagggagc	cttgggccct	agtccagtcc	tcccacaagc
20281	acctttctga	aggaaggggc	ccgctgggag	gcccgggtgt	gggcatgcct	agcctatctg
20341	tggcccctta	ccaagtcctc	tgtcctctgg	gtcttcccgg	acctgcagac	agatgtaagg
20401	cctcggattt	ccgcccctct	gcccagccca	tatctctctg	cacgaggcat	attctaggca
20461	ggttctgctt	tcccggtctc	atcacttaag	tcctgtcatt	tcgaaggcag	gcgccccgtc
20521	gtgtccccaa	agcatccaca	tttcccaagc	tcccttccgg	tccttgaggc	ccctcgggtc
20581	tcagcagcca	ctaaaatccg	cttgtctggg	gcggcagcct	caggtcttag	ctcattggct
20641	aacaagagat	gattgacagg	tcctgagcca	gagagcgagc	ccaccgggct	ctcagtccgc
20701	ccagctttgc	cgggtctcca	ggagcaggtg	tggctggacc	actggaatcc	cagtctgagg
20761	ccgtgttcta	gtgggcgcgc	agtttcctgc	ccgactaggc	agaatcctgc	ccgagcatga
20821	cactgtgggt	ggtttggtga	agtcctgttt	tctcttgcca	agaccaagta	agggcttgtt
20881	tgcctcagct	gccctcggaY	cccaacccct	agaaggtgaa	cctgaaaggc	atggaaatcg
20941	gggcaaggga	gggcctggga	cgggtggatt	tctcagccct	ggggttcagg	gttaggagtt
21001	aggagcgggg	aaggagtccc	agctggggga	tggggccgat	ctgtagtgac	tttgagcacc
21061	tcctaatgtt	ctcggttgcc	cgtccaccaa	gacctcagat	tcctggtggg	cttgcctggg
21121	ccccattagt	ggctcaaggt	cccgtttccc	agttttctcc	ctcctgggct	tcccagacct
21181	gcacagagtg	ggtgctcaat	aaatgttatt	tgagagaata	acagtgattc	catttactag
21241	gcagggggcc	ataagccaag	cttgaatctc	atagcaggaa	accccattta	cagagggaga
21301	aactgaggtt	catggggctg	gtttgtcctt	tctacccatc	gtttattgac	tgattgattg
21361	atgcattgat	tgagataagg	tcttgctgtg	tcgcccaggc	tggagtttag	tggtgcaatc
21421	atggctcact	gcagccttga	cctccccggg	tcaagtgatc	ctcccacctc	agcctcctga
21481	gtagcgggac	cacaggcgca	catcaccatg	cctggctaat	tttttatttt	ttatagagat
21541	ggggtctccc	ctttgttgcc	cagtctgttc	ttgaactact	gggctcaagc	aatcctccag
21601	ccttagcctt	ccaaagtgct	gggattacag	gcctgagcca	ccatgcctgg	cccacccatc
21661	gtattctgag	agccacagcc	agaggaagtg	ttctgtcctg	ggtggaatct	gccaccacga
21721	cttgggtctc	tgtcccgggg	ctccagcagc	cctgtaaagt	tttgtgtttt	tttagcattt
21781	ccaagacctg	tggtggggac	cgggattgat	ctgggagagt	ttggagagga	ggtgactggg
21841	aggcctYgcc	tgtgttgacg	tcaacccagt	gggttggttc	ccagactggg	cggctcagtc
21901	cctgagcagc	agcctcatgg	gtctctgcag	acaggtgggc	caatgtgaag	gtggagtgcg
21961	agccgagctg	gcagcccttc	cagggccact	gctaccgcct	gcaggccgag	aagcgcagct
22021	ggcaggagtc	caagaaggca	tgtctacggg	gcggtggcga	cctggtcagc	atccacagca
22081	tggcggagct	ggaattcatc	accaagcaga	tcaagcaagg	tgaggagctg	cccgcccacg
22141	tgtctgggtg	gagggcaggg	cctcccactg	ccccacccat	cctgtccagg	agcctcagag
22201	aatgttcctt	cctccctact	ggtggctgag	gctgacctct	caatgttttc	tctcccctcc
22261	tctcctgctg	cacccccaga	ggtggaggag	ctgtggatcg	gcctcaacga	tttgaaactg
22321	cagatgaatt	ttgagtggtc	tgacgggagc	cttgtgagct	tcacccactg	gcaccccttt
22381	gagcccaaca	acttccggga	cagtctggag	gactgtgtca	ccatctgggg	cccggtgaga
22441	tctccctctc	cctRtcacag	ggccacaaaa	tacaccccca	acctccaggt	gccaccccag
22501	ctgaaggaca	tcctagttac	tatcagaacc	tgcctggaac	ctcttacctc	tcagcagtcc
22561	ccctcctccc	caccaatgcc	ttcccttcca	tgtgagagac	tgccggggct	tgaatcctac
22621	ctccacctcc	acctccaagt	agccaagtca	ccttgggcaa	gttactagag	ggtcactggg
22681	gagatcagag	gagttaattc	tcgtgaaacc	ttaggcacag	tgcctggcgc	attcttggtc
22741	tcctcccagc	tgcccttccc	tgccagaagg	tggcatcaga	acccacatta	tgtgcagata
22801	ctttgcaagc	agggctgcac	tctgccagcc	ctcgccccca	gtgctctacc	cagtccaggg
22861	tcctgtcatc	tcaagagatt	gttgggtttt	atgacaattt	gccatggttt	gggcttagat
22921	gtggtgtaag	tgaaggaatt	gatggagggc	ttcaagcaga	gatgaaagac	ccttaaaaaa
22981	gggacaaagc	cagctgagtg	tggtggctca	tgcctataat	cccagcacat	tgggaggctg
23041	aggcaggcgg	atcacttgag	gtgaggagtt	cgagaccagc	ctggccaaca	tggtgaaacc
23101	ccatctctac	taaaaataca	aaaattagcc	aggcgtggtg	gcagatgcct	gtaatcccag
23161	ctactccaga	ggctgaggca	agagaatcgc	ttgaacctgg	aaggcagagg	ctgcagtgag
23221	ctgagattgc	accactgcac	tccagcctgg	gtgacagagc	aagaccctgt	ctcaaaaaaa
23281	aaaaaataaa	ataaaaagga	gaaagccgta	gggacacaga	ccacccttcc	tagggacaga
23341	caggatgttc	tgctgtcaca	tactgcaaac	agtgctgtgg	actgtagtgg	cagtcatttg
23401	ccttagggga	tgctatttaa	gaattttaaa	acaattatgt	attgagtatc	taccatgtgc
23461	cagtcatttt	tctgggtgct	aggatacaca	aacacgcctg	ccctcagaat	ggagcttaga
23521	gacagacata	ctgctggctg	ggggcctgtg	gatactgggg	agggcgaaga	cagaagcagg
23581	ggccgaggac	taaattcctc	ctcagcttca	tcagctgaga	ttctggtctg	ggcacactgg
23641	cctctgcaca	ctctggccct	gcaggcacta	gctagacgcc	ttgggaatcc	aagctgtcta
23701	tcctgccatc	agttactcta	acaatcttag	ccagtttgtt	tttgatattt	ataaaacgag
23761	ttatcaataa	tgtaaaagga	cgcctttcct	tttttttttt	ttttttttga	gatggagttt
23821	caccctgtcg	cccaggctgg	agtgcaatgg	cacgatcttg	gctcactgga	acctctgcct
23881	cccaggttca	agcgattctt	ctgcctgagc	ctcccaaata	gctgggatta	caggcatgca
23941	ccaccacaac	cggctaactt	tttgtatttt	cagtagagat	ggggtttcac	catgttggcc
24001	aggctggtct	tgaactcttg	acctcaagtg	atccgcccac	ctcggcctcc	caaaatgctg
24061	ggattacagg	catgagccac	cgcgccgggc	caggatgcct	ttcccattta	gacaatgctt
24121	gttaagtttc	aaggcgtttg	cacatgaact	gcttgtgctc	tcatccaccc	tgtgaggctt
24181	atgggttcat	ccYgccttcc	ccattgcaca	gctgggacac	agacatgtca	gaatcacaca
24241	gtaagtcaga	gacagggcca	gctctaggaa	ccagattcca	agaaggattt	gggagattta
24301	tggggaggtg	ggggttgaga	ttcttcctca	ccctgtgtcc	gtaggaaggc	cgctggaacg
24361	acagtccctg	taaccagtcc	ttgccatcca	tctgcaagaa	ggcaggccag	ctgagccagg
24421	gggccgccga	ggaggaccat	ggctgccgga	aggtgagggt	gtttctggag	ctgccctgag
24481	tggggccacc	tgtcagaggg	gctaccaggg	gagggagagg	tggatgaact	cctgctgcct
24541	cgcatggcat	cgccctctcg	tcggcacccc	cttccctgag	ctctccaaac	tgctccttta
24601	ttgaaggagt	gatactggat	gggatgggac	gggtgggcgc	tgttgggagg	aagcagagct
24661	ccccaccccc	agcccagtcc	tgagtccctc	cccatggggg	aagccacttc	ctcgagacag
24721	cagagaacag	ggaggtgggg	gctggtctac	ccccgagtgc	cccctcagag	tccagcctag
24781	tcatgtcaag	cagtggctgc	cgaagtgaag	tgtggcccct	gtgcaccgcc	agtcctgact
24841	tccccctcct	ctgccgtctg	acacagggcg	tgtgctggtc	tgtctcccct	ggaggagtga
24901	ggccactcag	ggtggggctg	caccttcccc	ctccttgtgt	tcccagcccc	agtgggcttc
24961	tagaggatgt	ttagggaggt	tgaggggggg	ggtgtcaagg	aatgaaagct	gtgtaagtga
25021	gtggggggtg	agtgactgag	ggtgtgaggg	ggtgacagac	cctctcctcc	tccagggagt
25081	ggagcagggg	tgcaaatgct	gtgatgggtg	cggggagctt	gcttctaaaa	gacactgctt
25141	ggcccttggc	cccccccagc	agccccttgc	agccaggctg	gctcctcact	ctgttttcct
25201	ttggattaag	cccctaccac	acccacctgg	accccaaagc	ctcccccaga	aaatgagcag
25261	gaaacactaa	caggcatggc	cccatgggcg	aggaagcaga	ggggagagca	gagcccagct
25321	gcggagtctg	tggactggca	aggacagtgc	ctggcccagg	ggctgtgtca	tggctgcgaa
25381	gaggtgaagg	gaggagtaga	gaggaattac	caacttctct	ggcaccaagg	ccagcctgga
25441	atttgtgtgg	ggagtgttga	gggtccatgg	ttaacagccc	aggatcacca	ggggtcttgg
25501	cacagcccct	gccagcagat	gaggccccca	ccacacatac	cacatctgct	tctcttctgc
25561	cttggctcct	gccagcctcg	cctgccaggg	tctcgtctct	gagcccctcc	tgccatcccc
25621	gggccaggag	catcctgcgc	cgactccagc	tttgccaggc	cctcgaggac	tgcccatccc
25681	ctctccatcc	tggcagctct	ccccagcctt	tagctgtggt	ttcccagcca	acagtaattt
25741	ccccactgtg	tctcttggtt	taaatgccca	agagaggagc	ctgaagggcc	attcatcttc
25801	ccgagccggg	tcactggccg	gtcgctggtg	gcctgccaat	cagccacgct	ggggctgggc
25861	ctccacccca	gcttccacag	ctgtgggtga	tggtggaggg	ggaatgtgga	gaaacgaggt
25921	gcagaacaca	gcccagtact	caaaccagtc	ccctccgtcc	tgagcacgtt	cagtgatgtc
25981	cctgatggca	tctcccacca	caggatttat	gggtgagggt	ggagagtcat	cttccctaca
26041	gacacccctc	ttctgtccac	tcttgagcca	gggttggacg	tggcacagcc	catcctgcta
26101	ctggctggga	gaagaccaag	tgacctacag	tgaggcccgg	cgcctgtgca	ctgaccatgg
26161	ctctcagctg	gtcaccatca	ccaacaggta	cagcaggggc	gggtgccctg	actagccctt
26221	gcccatgtct	gggcctattg	tggtcccttc	agcaaacagg	gtagcatctg	ccatcatgcc
26281	cagagggacc	tggagtcctg	tgaacctcag	tgggctccag	ggcattttaa	aatcttgtca
26341	gaagaatgac	tctcacttgt	taagtgaccc	cagtgtaggg	cagggcccgg	gcaggcacag
26401	gtgtgggctg	gatacttgag	aaagagaggc	cttggttgtg	tctgattttc	tctactttct
26461	tctcagcaaa	gcaaggggtg	cagagaatag	aaggggcagc	tgggggttcc	ataaatcagc
26521	tgcagggctc	ccaggcgtcc	ctgctttctt	gagcaagtta	ttggtcgggt	gcagcacccg
26581	agctcccacg	gtagggcgtc	tggcctgtga	ctgggggatt	gggaagcagg	gagatccctg
26641	ccctgaccag	cctgtctcct	gaaggttcga	gcaggccttc	gtcagcagcc	tcatctacaa
26701	ctgggagggc	gagtacttct	ggacggccct	gcaggacctc	aacagcaccg	gctccttctt
26761	ctggctcagt	ggggatgaag	tcatgtacac	ccactggaac	cgggaccagc	ccggtgagcc
26821	ccttMtttga	cttgccttgg	tgaagcgagg	agggaggcca	gggtggactg	gccctgccag
26881	caccgagccc	cagggcttcc	ccataaacag	atcattggtg	cactgtggtg	tagtgtctat
26941	gagcacaagc	tctgaaacca	aactgcctgg	ctccgatcat	gactctgcca	tcttttagct
27001	gtgcatcctc	tgagcctcag	ttttctcatc	tgtccagtgg	gaataatgat	cctttcctca
27061	tagggatgac	atgagtctta	aatatgtgta	aagtgctaat	atgtgtaaag	agttaatgtg
27121	tgtaaagtgt	ctagattact	tctctatctg	ggctcacaaa	aaagaaacaa	ataatctctt
27181	ctctatctgg	actcatttaa	aaaatgtgtt	cagaatactg	agcgcaatac	aagtgcttgt
27241	tattactatt	attaccattt	cacattcatt	atctttctaa	ccccttcaat	aacctgatga
27301	ggtagatgat	gaagcaggct	cggtgaggtt	aagcagcttg	cctgagccct	cacagtgggt
27361	gaacccagag	ccagggctct	gcctccattc	ccttcctccc	tcctggctcc	aaccccagag
27421	agcatgtctc	tgaagaggtg	gccaagctgg	ttcccagtgt	gagggccgtg	ctagtgccct
27481	gccgggatgt	gagggaggac	cagactatga	atccttctca	gagcctgggt	ctcccttccc
27541	tctccttcag	ggtacagccg	tgggggctgc	gtggcgctgg	ccactggcag	cgccatgggg
27601	ctgtgggagg	tgaagaactg	tacctcgttc	cgggcccgct	acatctgccg	gcagagcctg
27661	ggcactccag	tgacgccgga	gctgccgggg	ccagatccca	cgcccagcct	cactggctcc
27721	tgtccccagg	gctgggcctc	ggacaccaaa	ctccggtatt	gctataaggt	agggcagcct
27781	gttggccggg	tagggggcag	ggggaggaca	ggagcaaaga	gacagtttgg	atggaggtcc
27841	cagtgggacc	agccacaatc	cagagacaca	ccaggctgca	gacgggtgat	ttctggtgag
27901	acttgtccat	ggaatctgga	ggcctggtgc	tcagtaatca	tttgaggaat	tgagggaacc
27961	acagatcatt	gatttcagag	gttcccaaat	gttggggcca	gcctagctgt	tcttcagaat
28021	tgcttgggga	acctgataaa	aataaaatct	tggccgggcg	cagtggctca	cacctgtaat
28081	cccagcactt	tgggaggtca	aggcgggtgg	atcacgaggt	caggagatcg	agaccatcct
28141	ggctaacatg	gtgaaacccc	atctctacta	aaatacaaaa	aattagccag	gtgtggtggc
28201	aggcgcctgt	tgtcccagct	actcgggagg	ctgaggcagg	agaatggcat	gaacccagga
28261	ggcggagctt	gcagtgagcc	gagatcgtgc	cactgcacgc	cagcctgggt	gacagagcga
28321	gactccgtct	caaaaataaa	taaataaata	aataaagata	aaaatctagg	ctgtcacaat
28381	ggagatttag	attcattagg	tctggattgg	gcctggtaat	ctgtattttt	aatcacgcta
28441	ggtttgggag	ccactggcag	agtccgaggt	cttttattat	gcacagaaac	tgaagtctag
28501	ggagaagaag	ggacttaccc	acgttaagct	gtggctctgc	tgggattaga	gcccagatct
28561	ccctgctggt	caggggatgg	ggctcagggg	ccctctccag	aaggtgactg	tgccagctcc
28621	cctccccaga	cctctgcaga	tgaacaggat	tgtccttagc	tagcctKagc	cccctgtcca
28681	gtaaggctcc	aggcccctcc	tctgccatgg	tgggaaaggc	agtaggtgcc	ccctgagggg
28741	tgggccagtg	gggacagctt	agacagctgg	actctgcccc	tgcaggtgtt	cagctcagag
28801	cggctgcagg	acaagaagag	ctgggtccag	gcccaggggg	cctgccagga	gctgggggcc
28861	cagctgctga	gcctggccag	ctacgaggag	gagcactttg	tggccaacat	gctcaacaag
28921	atcttcgggt	actgagccgg	gctgaggcgt	gttaggaggg	cacccgcaca	cgtgtaggag
28981	caggcatggc	cgacagaccc	ttggttttgt	tgggcgagca	gggggatggc	agaatgtggg
29041	tgaccccagg	gaggcctgca	tctgctgctg	gtgccaggac	catcttgtcc	tcactcaagt
29101	agccatggtg	ccctggcatc	ttgggagaac	aggctggtgt	gatccatgca	ctcataggag
29161	actgtgtttt	gctcaccatc	atccccccag	caatgctcca	acagacccac	aaacttacat
29221	atgtaccccc	caccccattg	caaaatctcc	cacatgctgg	tcctggcaag	tgtttcccct
29281	caccttacac	catcctacaa	tgacccacac	tcctcaatcc	acagtttttc	ctgagagata
29341	ggaggagaaa	ggccgcagct	atgaggattt	gcccatgggc	ctccctctga	gacaccacct
29401	ctgtcctggg	ctctgagcat	tagcacgtgg	aatcccctag	cactgggaaa	atcgagatgg
29461	atctgggctt	cctgatagct	taattgaagg	gatctctcct	ctcagcaaac	attgaaatta
29521	cattatttgt	ctcataatta	caatagctca	tggtcatcac	ttctcaccac	gtaccaggca
29581	ctgtgctaaa	catatagtcc	tcactcaagc	ctcccgacaa	ccctatggag	cagacgttaa
29641	cccctgaccc	ttgtgggttg	atagagaggt	tatttgccca	agttcatggg	tgaacggata
29701	cttgaatcca	ggtttattta	actccagagc	cgtagatccc	tgccacctcc	tcatctgaac
29761	ttcctaaact	ccgtaaagta	aaagcctgca	gaatcttgct	ggacagggca	cccccaccca
29821	aaaggaaccc	aaacaaaggg	gaggggccac	tgccccttga	gtggatggct	tggtccagct
29881	ctccccagct	ctgtcttgtg	gggagaactt	taccgaagtg	acctcaacgc	tgtatcgatg
29941	ggtcaatgtg	aagcccagat	ggagaggccc	caggccctgg	gggctgcccc	ggtcacagct
30001	gcaagggaca	gggggcacgt	ttgggttcct	gcccctctca	cttcccatct	cttccgtccc
30061	cactcctggg	ttgtgctgaa	gtgaatcaga	acccgagatc	cacgagcagc	actggttctg
30121	gatcggcctg	aaccgtcggg	atcccagagg	gggtcagagt	tggcgctgga	gcgacggcgt
30181	aggggtgagg	gggcctgggg	tacttgggac	tgcgaggccg	ggagcttggt	gggcggggcc
30241	tgtttggggc	ggggcctgga	ggtgggcggg	ttttcttgag	ggccgggccc	ccagtcggag
30301	ccggcttcag	gaaagcaggt	ccgagagggg	tcacccggcc	cccggtgaga	attcgcagct
30361	caggccaggc	ctcttgttca	cctgttccgg	gcatgggggc	ggcctgcacc	ttgcgcctca
30421	cgttcctctt	ccctccaccc	gcctcctcca	gttctcttac	cacaatttcg	accggagccg
30481	gcacgacgac	gacgacatcc	gaggctgtgc	ggtgctggac	ctggcctccc	tgcagtgggt
30541	ggccatgcag	tgcgacacac	agctggactg	gatctgcaag	atccccagag	gttggccgga
30601	gtggcgctgg	gggacgcggg	atggagcgaa	gggtggcggg	gccaggaatt	ccagggaggg
30661	tctcctttcc	tcacaacgtc	tttgtccttg	ttcccctagg	tacggacgtg	cgggagcccg
30721	acgacagccc	tcaaggtgag	caccccccag	cccatcccgc	tacccatcgc	gtgggagagg
30781	gcgtcaactc	tggggtaagt	cccgagaggc	ctgaatgaaa	tggaggggat	gaggagttcc
30841	ggtcgagaga	agggggacgg	ggttggctcg	gacggaggca	gccacagccc	tgtttgcttc
30901	cgtgtgggag	gcgaggcaag	cctggggcct	ggggcctggc	acggtgcctg	cctgggtccg
30961	gtgtgcctgc	aggctcgcct	gctgccgcct	ggctctgccc	cggccctgcc	gcgcccgcct
31021	ccggggcctg	gcgtgcagcc	tctgcctggc	cgccgctccc	acgcccgcgc	tgctcctgca
31081	ggccgacggg	aatggctgcg	cttccaggag	gccgagtaca	agttctttga	gcaccactcc
31141	acgtgggcgc	aggcgcagcg	catctgcacg	tggttccagg	ccgagctgac	ctcggtgcac
31201	agccaggcgg	agctagactt	cctgagccac	aacttgcaga	aggtgggcat	tggattgagc
31261	agggggctgc	aggctggggg	agggcaggcc	cgggatgagg	gcagggggct	gcctacccac
31321	acctgcccgc	ctggcttctc	cagttctccc	gggcccagga	gcagcactgg	tggatcggcc
31381	tgcacacctc	tgagagcgat	gggcgcttca	ggtaggaacc	caggcaggca	gcagatgtgg
31441	aagggggctg	gctgtccaca	cacggagcac	agaggcagac	ttgcatttga	atccagccct
31501	gccccttcct	tgctggctgt	gtggccttga	gcaagatact	taacctttct	gggccttggt
31561	tttctcatct	gaaaatggga	atatgaggcc	tgcctggtaa	gatttttgtg	aagattagaa
31621	ataacatatg	cgaagtgctt	acgcagcatc	cagcacatta	gttactaaat	aatggcagct
31681	cctgttacgt	ctggtgtcat	tcatcatgac	taaggccctc	tcggggaagt	gggcagaaca
31741	tatgatgatc	cgggggcctc	tttgtatttg	gtgcctactt	accatgtact	ggggggcttg
31801	aggcaggaag	gaccaggagc	acctgggact	cagaatttga	gcttgtcttt	ttgcccttgg
31861	gcttcctgcc	ctggagtcct	caggcttctt	ttctggagca	gcaagtgtcc	agggacagct
31921	ggggccttat	ctagaggcac	caggtccttg	ggtctttgac	tgccctgagc	tcagtagctc
31981	cacccctcag	cctacagcca	ctaaacccca	gaacctgggc	ccttccctgc	ccccattcct
32041	gcggccttca	ttgctgcatc	cggtggaggc	ccagctgggg	gccggtgctg	gagttacctc
32101	tgctccatgc	cattgcagat	ggacagatgg	ttccattata	aacttcatct	cctgggcacc
32161	aggcaaacct	cggcctgtcg	gcaaggacaa	gaagtgcgtg	tacatgacag	ccagccgagg
32221	tgagggcaag	gtgggggcag	agtgcgcagt	cagctgtgca	RagggttRat	gctgggcgag
32281	cctgggcaga	agtcatcagt	ctgttctcat	tctctttgtt	cccacaaccc	aataaaggct
32341	agactcagcg	aggggtggac	ctgtctccat	ggtccagaag	acttgaattc	ggagctggac
32401	acaggccctg	agcctctgcc	cagactcctc	tcagggcatg	aggctgagtg	tgctgccagc
32461	catgccctgc	cctgctctgc	cctgggggtg	actgccctcc	cctccccttt	ccgcagagga
32521	ctggggggac	cagaggtgcc	tgacagcctt	gccctacatc	tgcaagcgca	gcaacgtcac
32581	caaagaaacg	cagcccccag	acctgccaac	tacagccctg	gggggctgcc	cctctgactg
32641	gatccagttc	ctcaacaagg	taggaggtgg	caatggggca	cccaagggag	tcaggggaga
32701	ggacgtgaac	agggaaaggc	tgagcctcag	gagtcctggc	cttttggcag	caccaaactc
32761	atggcctctt	gcctgtaccc	accaacttct	ctttcacctg	gctccagtac	cagggccaga
32821	ctccttggaa	aatgactcac	tgtagtagca	ccttccaatc	ctccgggaag	caMggttgtc
32881	caaataattt	ggtgagtgtt	ctagatcagt	gattgccaaa	gatttttttt	tttttttttt
32941	gagaaggagt	ttcactcttg	tcacccaggc	tggagtgcag	tggcgcgatc	tcggctcact
33001	gcaacctctg	cttcctgggt	tcaaccaatt	ctcttgcctc	agcctcccga	gtagctggga
33061	ttacaggcac	ctgccaccac	ccctggctaa	tttttgtatt	tttagtagag	atggggtttc
33121	accatgttgg	ccaggctagt	ctcgaacccc	tgaactcagg	tgatcacctg	ccttggcctc
33181	ccaaagtgct	gggattacag	atgtgagcca	ccgcgcccgg	cctgattgcc	ggcctgatta
33241	tcaaagattt	tgataatgaa	ctcctattag	taaaacaaaa	tattgagctt	acatgaccaa
33301	actatgtgtg	tgtacattta	acttatatat	gtatatgtgt	gtgtaaataa	aacctacttc
33361	catactaata	tgactaatat	tatatatagt	aaaatatgta	taagaacaaa	agagtataaa
33421	acattagcta	aagattttta	aatactttta	agtttaaaac	atttttttgg	ctgcgcgtgg
33481	tgggtcatgc	ctgtaatccc	agccctttgg	gaggctgagg	cgggtgaatc	acctgagatt
33541	aggagttcga	gaccagcctg	accaacatgg	agaaacccca	tctctactaa	aaatacaaaa
33601	ttagctgagt	gtggtggcac	atgcctgtaa	tcccagctac	tcgggaggat	gaggcaggag
33661	aattgcttga	atcctggagg	cggaagttgc	ggtgagtcaa	gatcgtgcca	ttgcactcca
33721	gcctgggcaa	caaaagcgaa	actccgtctc	aaaaaaataa	acaaagaaaa	aaaaaacaac
33781	aaaaaaaaca	cctttttttt	tttttttttt	ttttactagt	ggtatgaaaa	catttttttg
33841	tgctcactca	aaagtgatta	attggctggg	agaggtggct	cacacctgta	atcccagcac
33901	tttgggaggc	tgaggcagga	ggatgacttg	agcccaggag	ttcgagacca	gtctggacaa
33961	catggagaga	ccatgtctct	acaaaaaata	ggaaaattaa	ccaggtgtga	tggtgcacac
34021	ttgtagttcc	agctacccag	gaggtgggaa	gtgggaggat	ctcctgaacc	caggaggtag
34081	aggcttcaat	gagccatggt	catgccactg	tataccaccc	tgggtaatgg	agtgagaccc
34141	tttctccaaa	aaaaaaaaag	atcaattata	ataattattg	tttaatatgc	tcactttggc
34201	agcacatgta	caaaaagtga	aacaatacag	agaagattag	catggccctg	cacaaggatg
34261	ctatgcaaat	tcctgaaggg	tccatatttt	gcgtagttca	tgaaagttga	aggttgttca
34321	acaaaaaaat	tgtctaaata	attttaataa	gagcaatgtg	attacatgta	cttcacgttt
34381	ttaaaaaatt	ttagtctgac	actttatgac	tcatgactca	caggtctaac	gtgttgaaaa
34441	tcaaagttat	ttcaaaacat	gcatttcatg	gtggctatag	attaaatatg	cctcacaaag
34501	acaaatagat	tgaagtgaaa	aaagttcatc	catcatttct	aaataattct	ccccattttt
34561	agtccttcta	ccaattaaac	aaacattttt	gtttaaaaat	tggctagtag	gctgggacgc
34621	tgagcactgg	gaggatcact	tgaagccagg	agttcgagac	cagcctgggc	aatgtagcaa
34681	gaccctatct	agaaaattct	ttttccaagt	gttttgagtg	tgcaggtagg	aaagtttggg
34741	gcactgacat	taatcactat	ggatgcattt	ctcaacacgt	ttttacaaca	ccccctccat
34801	agtgtgagtt	tcttccccac	agtcgttatt	tttccatgca	caggctgatt	tattagacct
34861	gattagtcct	tcattgtttt	tacctggcga	ttgacaacga	gttcatacca	ggaagagaag
34921	gttgtcattt	tccttgttat	gtgccagggt	aattggcatt	aatctcaagc	catggcttct
34981	ttgcaggaca	ttttaagaac	acttagccct	gttgtgaaga	ttagattagt	taacactgaa
35041	taatataatc	cacaaatcct	tgtcatacac	aggaaggcag	ccagcctctt	agtgtcatgg
35101	atctcctgcc	ctcctcagaa	tattcaaaag	aacattacac	ggccaggcgc	tgtggctcat
35161	gcctRtaatc	ccagcacttt	gggaggccga	ggcgggtgga	tcacctgaga	tcaggagttt
35221	gagaccaacc	agggcaacat	cgcaaaaccc	tgtctctact	aaaaatacaa	aaaattatct
35281	gggcatggtg	gtggacgcct	gtaatctcac	ctactcggga	ggctgaggca	gcagaatcgc
35341	ttgaacctgg	gaggcagagg	ttgcagtgag	ctgagatcga	gccactgcac	tccagcctgg
35401	gcgagagatt	gagactctct	ctcaaaacaa	aacaaaacaa	aaaccacaMa	aaaaaaaaat
35461	tacacctctt	ctaccttaaa	aaattaaggc	atgtatatta	ttaaaacttt	ggaaaataca
35521	gaagagaaac	caaaactcac	ccaacactct	ctagagatca	cagctatcaa	tatttgttat
35581	tctccttcct	gcctttttcc	atggaattga	gctcatacta	aataatataa	tttcctaccc
35641	aactcttctt	tctctgtatc	atattttgag	catctctcat	gttataaagt	ttttccaaaa
35701	acttgttctt	tttccatcca	ctttttaaac	agaatgtatt	ttatatatgt	aataggtccc
35761	attcttaatc	atcattgtca	agataccagt	tactctcctg	ccctgtggaa	agttctgttt
35821	gtttttgttt	ttgagacagg	gtcttgctct	gtctcaaaaa	ctgctggagt	atggtggtac
35881	catcatggct	tacttactgc	agcctcgacc	tcctaggctt	aagtgatcct	cctgcctcag
35941	cctcctgagt	agctggcact	acaggcttat	gccaccatgc	ccagctaatt	tttctatttt
36001	ttttgtagaa	atggggtttt	gccatgttgt	ccaggctggt	tttgaacttc	tgggctcaag
36061	cgatcctcct	gccttggcct	tccaaagggc	agggattaca	ggtgtgcgcc	actgtgcctg
36121	gcctgtggaa	agctctggaa	gtatgctagg	gtgttcactc	cttcactgcc	tgccctcaca
36181	catcttgctt	tactagttct	gtgcccttct	ttgtgtccct	atagcatttg	gatgtaggta
36241	aagcatttat	ggcagctgtc	cccaaccttt	ttggcaccag	ggactggttt	cttggaagac
36301	aatttttcca	tgtactaggg	gaggggaggg	atggttttgg	gatgaaactg	ttccacctca
36361	gatcatcagg	cattagattc	tcataaggag	cacgcaacct	agatcccttg	catgtgcaat
36421	tcacggtagg	gttcgcactc	ctatgagaat	cttggctggg	cgcggtggct	cagcctataa
36481	tcccagcact	ttgggaggcc	taggtgggca	gattacctga	ggtcaggagt	ttgaaaccag
36541	cctggccaac	atggtgaaac	cctgtctcta	ctaaaaatac	aaaaattagc	caggtgtggt
36601	ggtgggcgcc	tgtaatccca	gctactcggg	aggctgaggc	aggagaatag	cttgaacctg
36661	ggaggcggag	gttgcagtga	gctgagattg	cgccattgca	ctccagcctg	ggcaacaaag
36721	caagactcca	tctcaacaac	aacaacaaca	acaacaacaa	caacaacaaa	gaatctaatg
36781	ccctgctgat	ccaacaggag	gtggagctca	ggctgtaatg	ccccttcgcc	ccKctgctca
36841	cctcctaaga	ggccggggac	ccctggtttg	tgggacagcc	tcttccacta	gctttaagct
36901	cctggagggc	agggccacta	gcacctgcca	taccccttaa	tacacttgca	cRtggcaggg
36961	atgccctcag	tgtcggctgg	actgagctga	ataccctccc	cctttagctg	tcacttcttg
37021	ctggtactgg	tgtgaccttg	ctgcttccaa	gtttatgatg	aattctactc	atgatttaag
37081	ttgggcctca	gcatggctct	gaaactactt	ctgtgaaacc	aaatccttga	actttgtgac
37141	agacctccaa	aaatctgcat	tatttctggg	cttacaattt	tttaccccaa	atctgccatc
37201	tgcatcagta	aggatggtgc	tggagctaat	tattaatagt	cacagctctc	actggttaag
37261	tgcctactgt	gtcatgtact	gttatcttta	atccttaaaa	tgatccccaa	agacaggctt
37321	tgtattacca	ctttacagaa	gagtaaattg	aggccataag	gttgtcagag	ctggaatctg
37381	acatctcccc	cttacctgaa	tcccacccct	gtctttatga	ctccaaagct	tccctacacc
37441	ctttcttttt	ttttcttttg	agacagagtt	tcgctcttgt	tgcccaggct	ggagtgtaat
37501	ggcgtgatct	cagctcactg	caacctccgc	ctcctgggtt	caagcgattc	tcctgcctca
37561	gcctcccaag	tagctgggat	tacaggcatg	tgccaccacg	cctggctaat	tttatatttt
37621	tagtagagat	ggggtttctc	catgttggtc	aggctggtct	cgaactccag	acctcaggtg
37681	atccacccgc	cttggcctcc	caaagtgctg	ggattacagg	tgtgagccac	cgtgcctggc
37741	caacaccctt	tattttccat	cacactgcct	ctgagcagaa	aatcattaga	tattcatttt
37801	cctaagaaag	agtcttcact	tgatgagaga	tttcctaccc	agggcttttg	tttgtttgtt
37861	tgtttggaaa	ccttatagag	ctaatgaaag	tgggaaaaga	gaaatgtaaa	attacagagt
37921	tagaagctgc	tgctaataga	tcattcaaca	atagagataa	aagYgtccta	gggctgggcg
37981	cggtgaaacc	ccgtctctac	taaaaataca	aaaaattagc	tgggcatggt	ggtgggcgcc
38041	tgcagtccca	gctactgggg	aggctgaggc	aggagaatgg	tgtgaaccct	ggaggtggag
38101	cttgcagtga	gccgagatgg	cgccactgca	ctccagcctg	ggagacagag	cgagactctg
38161	tcttgaaaaa	aaaaaaagtg	tcctagagat	gatcatgtaa	gttcaaaggg	caagataatg
38221	gatgtcagac	aacattcgga	agggtgttta	gcagaaagca	agatagatcc	ttgtccccat
38281	cttcctagtg	cttggcctag	gcactgttgt	catagccttt	gacggcccaa	agaaatcctc
38341	ccatttgaag	atcccctgga	gtgtgggcag	gtgtgtgtga	atctgcagtg	ccaagctggg
38401	aggtgctgga	ggctgccaag	cagacccagc	tgtcctggtt	ctcagatact	gttctctccc
38461	ggccctcaaa	ggccccccag	gacctgctgc	tgaggggcgc	acagtggcct	ttctgggttt
38521	gtggatgggg	tggtggggct	ggccattaca	tccccacctc	tgccccacag	tgttttcagg
38581	tccagggcca	ggaaccccag	agccgggtga	agtggtcaga	ggcacagttc	tcctgtgaac
38641	agcaagaggc	ccagctggtc	accatcacaa	accccttaga	gcaaggtagg	gccagcctat
38701	ggggagcccc	cagtatcctc	tgacactgtc	cccccaaata	gctatagcag	agtcactcac
38761	aactgtcttc	tggggaccat	agcattcatc	acagccagcc	tgcccaatgt	gacctttgac
38821	ctttggattg	gcctccatgc	ctcgcagagg	gacttccagt	gggtggagca	ggagcctttg
38881	atgtatgcca	actgggcacc	tggggagccc	tctggcccta	gccctgctcc	cagtggcaac
38941	aaaccggtga	ggatgccctc	cctgttcccc	tccgcaccgc	gctgccctaa	gcctgtgggg
39001	ctgcctttgc	cccagcatct	cttgccccag	ggtctccctt	cttccagcct	ctttgctcac
39061	attgcagcct	tctggggaca	gtagcacagg	gaggcagctg	ctggggctcc	cctgagcagc
39121	tccctccccc	cagaccagct	gtgcagtggt	cctgcacagc	ccctcagccc	acttcactgg
39181	ccgctgggac	gatcggagct	gcacggagga	gacccatggc	ttcatctgcc	agaagggcac
39241	gggtatgtgt	caccagtcac	ctgggaaacc	ccagtggggc	cctggcaccg	ggctggatgc
39301	tgggaccatg	ccaggaggaa	ggaatcatgg	tccctggcag	agcagggctc	tgcttgggaa
39361	gcagatgggc	agaaaggcaa	ggtgccaata	agatggaaaa	gcaatagcac	ccacaggtct
39421	caggaggaag	atttgggggt	atggagggct	cgttgggtcg	gggggagagc	tagacgctgg
39481	gctgcatgaa	gtgctggcac	gtgtggcgtc	aaggaccctg	aggttccagg	tccaagacac
39541	ctccagctcc	atgcgtaggt	ggcctctgcg	ccgggttcct	tgggtaggag	gaggtcaagg
39601	ccctcacctc	cctgtccatt	tgttagcaaa	catgtattat	taataacaac	aggRctgaca
39661	cctaccaagc	cttggtctgg	gccaagcgcc	gagtctggtg	gagaccKggt	ctttgcctgg
39721	tgtgcggcct	tctcctggcc	ttgtgcctgg	gaacggggtg	agggaagcag	agcccagcct
39781	gaaccctgac	cccttccctg	tagacccctc	cctgagcccg	tccccagcag	cgctgccccc
39841	cgccccgggc	actgagctct	cctacctcaa	cggcaccttc	cggctgcttc	agaagccgct
39901	gcgctggcac	gatgccctcc	tgctgtgtga	gagccgcaat	gccagcctgg	cctacgtgcc
39961	cgacccctac	acccaggcct	tcctcacgca	ggctgcccga	gggctgcgca	cgccgctctg
40021	gattgggctg	gctggcgagg	aggtgggctc	ccgacacttt	tgccctgggc	cYcagccttg
40081	cccgggttcc	cctccctgcc	ccttcctgcc	cccgccttat	ccgcacccta	tcctgactat
40141	tcccttcctc	ccaccccatg	gccccccatg	cccagggctc	tcggcggtac	tcctgggtct
40201	cagaggagcc	gctgaactac	gtgggctggc	aggacgggga	gccgcagcag	ccggggggct
40261	gtacctacgt	agatgtggac	ggggcctggc	gcaccaccag	ctgtgacacc	aagctgcagg
40321	gggctgtgtg	tggggttagc	agtggtgagt	gcccacctgc	cagggcgggg	gcatgggcaa
40381	gctgtcggtg	gccccgggga	gggtgctgag	ccacttctta	atcctgtacc	cccacagggc
40441	cccctcctcc	ccgaagaata	agctaccatg	gcagctgtcc	ccagggactg	gcagactccg
40501	cgtggattcc	cttccgggag	cactgctatt	ctttccacat	ggagctgctg	ctgggccaca
40561	aggaggcgcg	acagcgctgc	cagagaggtg	ggtgaccagg	ccagagccca	cacatggcgg
40621	gcaggtggca	cctcctctcg	tgggcactca	gacccatgag	tacatcccca	cactgctctc
40681	tacccatagg	cagcacttac	acaagatgcc	ctcgtgctct	cacatgtgga	gaccatacat
40741	gacactatat	gtgcatatgc	tgccccccca	cacacttgca	catgtgcaca	cacacacaca
40801	tgaatccaca	gactccacac	catcctctac	tcaggctgca	gagaagaggg	ctggagcagc
40861	tctgggggac	tctgcccccc	ccggagaccc	atccgccctg	acgtgggcct	tctttgcatc
40921	cagcgggtgg	ggccgtcctg	tctatcctgg	atgagatgga	gaatgtgttt	gtctgggagc
40981	acctgcagag	ctatgagggc	cagagtcggg	gcgcctggct	gggcatgaac	ttcaacccca
41041	aaggtgggtg	ccctgtgtgt	ggggtggaga	ggtcaagcct	caggctgtaa	ggggctgccc
41101	tccactttgc	cctgagcctt	gtcctggggc	ttgtcggggg	acagggagtc	ggttctagaa
41161	cacRcctgct	ctcctccacc	tactcctgcc	ccaccttgtc	cctgctccct	cagtgccttc
41221	tttcctgcag	gaggcactct	ggtctggcag	gacaacacag	ctgtgaacta	ctccaactgg
41281	gggcccccgg	gcttgggccc	cagcatgctg	agccacaaca	gctgctactg	gattcagagc
41341	aacagcgggc	tatggcgccc	cggcgcttgc	accaacatca	ccatgggtgt	cgtctgcaag
41401	cttcctcgtg	gtgagcgccg	ggcaggccca	cgctcagcct	ccttccaccc	cgtgccgctg
41461	gtcctgggct	ggggctgggg	gctgcttcac	aactgcaggg	ggcacagccg	atgggaaggc
41521	ctgaacagaa	cggactgcgg	gcagctggga	cccccgggat	aaattagtca	gtgggatgga
41581	ctggacctga	aacttatcat	ccaaactaga	ccacaaggct	cgggggtcag	caaccccctg
41641	tcactttgta	gtggtcaagg	gcatggacag	agttcaagtc	ctggccatgt	cacttatcag
41701	tggtgtgacc	ttgggcagag	tctgtggcct	cagtttcctc	gtatgtaaaa	tgggaataat
41761	agtagtYcca	gactgatgtg	gtggctcatg	cctgtaatcc	cagcactttg	ggaggctgag
41821	gtgggcggat	cacttgaggt	caggggttca	agaccagcct	ggccaacatg	gtgaaacccc
41881	gtctctacca	aaaagtacaa	aaattagctg	ggcgtggtag	cacatgcctg	tagtcccagc
41941	tacttaggag	gctgaggcat	gtgaattgct	tcaaccgtgg	aggtggaggc	tgcagtgagc
42001	cgagatcgca	ccactgcatt	ccagcctggg	caacacagca	agaccctgtc	tccaaaaaaa
42061	aaaaaaaaaa	aaaaaagtcc	cgacctccta	gagtgctagt	gaagctagta	aagatgaggt
42121	gagttaggga	aggggctgac	acccaggcct	cccacgaggg	ctgggctgag	acctagctga
42181	gtgcagcatg	gcgttttccc	tttctggggg	aacctgaagt	cttgtctctt	gggcctgtgc
42241	ccccacagta	accagaggta	ggatgggagg	gggaactaga	gcctctttct	ccccagacct
42301	cccggcccag	gcctgtgtgc	tttgtatgtt	tacttaagtg	attattacga	tgatcactgc
42361	tattattaac	tggccccctc	ctcttgccca	cagctgagca	gagcagcttc	tccccatcag
42421	gtgagtgaaa	ggcaatgccc	ccaggtgggc	aggcaggaag	cactgctggg	cctaacgccc
42481	acttggcctt	tcacgcccac	tcgccttggc	agcgcttcca	gagaacccag	cggccctggt
42541	ggtggtgctg	atggcggtgc	tgctgctcct	ggccttgctg	accgcagccc	tcatccttta
42601	ccggaggcgc	cagagcatcg	agcgcggggc	ctttgagggt	gcccgctaca	gccgcagcag
42661	ctccagcccc	accgaggcca	ctgagaagaa	catcctggtg	tcagacatgg	aaatgaatga
42721	gcaRcaagaa	tagagccagg	cgcgtgggca	gggccagggc	gggaggagct	ggggagctgg
42781	ggccctgggt	cagtctggcc	ccccaccagc	tgcctgtcca	gttggcctat	ggaagggtgc
42841	ccttgggagt	cgctgttggg	agccggagct	gggcagagcc	tgggctggtg	gggtgccacc
42901	ctcccacaag	ggctgggctg	agacccagct	gagtgcagcg	tggcgtttcc	ctttctgggg
42961	gggcctgagg	tcttgtcacc	tggtcctgtg	cccccacagg	aaccagaggt	aggatgggag
43021	ggggaacgag	agcctctttc	tccccagagc	ccccggccca	ggcctgttga	tccgcgcccc
43081	aggaccccct	tctttgcaga	gcccgaggag	cctcccctgt	cccctcgggc	agatctgtKg
43141	tgtctctctt	cccacctggc	agcctcagct	ctgtgcccct	caccctgctc	cctctcgccc
43201	cttctctccc	accccttcct	tctgagccgg	gccctgggga	ttggggagcc	ctcttgttcc
43261	tgatgagggt	cagctgaggg	ggctgagcat	ccatcactcc	tgtgcctgct	ggggtggctg
43321	tggggcgtgg	caggaggggc	ctaggtgggt	tgggcctgag	aaccagggca	cgggtgtggt
43381	gtctgctggg	ctggagataa	gactggggag	agacacccca	acctcccagg	gtgggagctg
43441	ggccgggctg	ggatgtcatc	tcctgccggg	cgggggaggg	ctctgcccct	ggaagagtcc
43501	cctgtgggga	ccaaaataag	ttccctaaca	tctccagctc	ctggctctgg	tttggagcaa
43561	ggggaagggt	tgccagagtc	ctgggggccc	cagaggagca	ggagtctggg	agggcccaga
43621	gttcaccctc	tagtggatcc	aggaggagca	gcacccgagc	cctggagtgg	cccagtaccc
43681	ttccaagagg	ccacagtccc	agccaggaca	aagtatgcgg	cccatcctgg	tgcgacagcg
43741	tgggacaatg	tgaacatgga	ctcgaagaca	tggccctttc	tctgtagttg	attttttaaa
43801	tgtgccatta	ttgtttttaa	aaaaaaagga	aaaaagaaaa	gcaaacaaat	aaaacacctt
43861	taagaggctt	gaaagagaag	gttctgcctt	gtcctgtggt	gagcctgctt	cttcacgtct
43921	gtcccttcgg	agataactgt	tgttttggag	cttgcaccac	aggtgttttc	tgcagctggc
43981	cattttgcgt	ctgtctctgg	gcctctaggg	gacactctca	cccccgatct	ttaggagctc
44041	acccctctgg	gcctgcgcct	ccctctctct	gttcctgggg	gcttgaatgt	gggtgagaac
44101	tcaggagcca	ggccatctgc	tgctgagcag	ccagccgtgc	aagcttgggc	aacttagcac
44161	acctctcaac	atgtgcacag	tggggagaac	cggacccacc	tcctagggtt	gttttaagga
44221	tatgtgagga	tcaagggagc	tcatctgtgc	agagcactta	gaacagtgcc	tctgggctct
44281	gcaagcgcta	ggcgttactg	ccgtttctgg	gctgcggctc	caggggagca	cttgatgtgt
44341	ccaggccggc	cctgggtggg	ggctccacat	caccgtcctt	ccaaggcagc	catcatacct
44401	gccctctaac	agcctgaaag	ttcacatgtg	tccttaggga	gcctgggctc	tgaaaccaca
44461	gaaggcagaa	tggacggcag	gacctttact	cacctgcttg	ttcattcagc	cggtatttga
44521	gctggagatg	ccaacaaagg	aaggttaacc	aacgccaatc	gggcgaggca	gggggaagct
44581	gctaatgtgg	cctgtgtgtc	tggggagggt	ctcactagag	ggagtgagat	tgactgcagc
44641	ctgaaggagg	tggcggagtg	agcaatgcaa	atatctgggc	cagggctagg	ggggcatccc
44701	tggtgcttta	ggggaccagc	agggaggcga	ggtgggctga	ggctgagatg	agtcaggcag
44761	ggccagattg	tccaaggccc	tgaaggcagt	ggtagaatgt	agcattattt	tcaggatagt
44821	gggaagtcaa	tgggaatggc	taatcaggct	gaccttttaa	caagatcatt	ctggctagga
44881	gttgagaaat	agacaatgga	tgggaaacgg	gggagtgaaa	gcaggaaggc	tggtgcggaa
44941	gctcttgtaa	taattcaggc	acaacaagac	ggtggtttgt	tgggatcagg	actgcagtag
45001	tggtcagatt	ctgtgtgtgt	gtgtgtgtgt	gtgtgtgtgt	gtgtgcgcgc	gcgtgcgtgt
45061	gtgtgtgttt	tgccctgttc	atgatattta	aaataagttt	ccacttttat	gaatagacaa
45121	tgcagtcacg	cagtctgcat	tgcgtgggat	acctaaatga	tatcccaaga	tagatgttgc
45181	gcaagtcctg	cccctgcccg	tcgccctcca	gcctataccc	tcctgccctg	tcagtttcct
45241	gtctttccag	tgtttctttg	tgaaagcaaa	tgaacgccag	attggactga	agggatggcg
45301	gatgcccttg	ctggggatgg	gatctgcctg	gggaaaggca	gtgggagtca	ggaagcactc
45361	caagcttccc	gcctggactg	cagggtgaat	ggggtgctgt	ttcctgagac	aggagcccta
45421	gggagagccc	atgagctgct	ggcctgagtc	caggactacg	gtggagccca	ggggaccccc
45481	tccagcaatc	ctctctgtgc	cgccccagca	acagcaggac	ccatggaagg	cgcctaatca
45541	ctcaggggag	ggagtcccag	tcctgtggga	ggttcaccct	ggagtgagtt	gctatctagc
45601	cctgcagccc	aaacagctcc	ctttgtgagt	taagtgccct	gccactgccc	acagtgagag
45661	gtgaagccag	ctggacttcc	taggttgagt	ggggacttgg	agaacttttc	ttacaagagg
45721	tttgtaaaat	cagtgctctg	taaaaatgca	ccaattggtg	ctctgtagct	agctagaggt
45781	ttgtaaaatg	caccaatcag	tgctctgtaa	aaatgcacta	atcagcactc	tgtacctggc
45841	tagaggtttg	taaaatggac	caatcagcac	tctgtaaaat	ggaccaatca	gcaggacatg
45901	ggcggggaca	aataagggaa	taaaagctgt	gtcctcccca	cccaccccac	ccctagcagc
45961	aacccgctca	ggtcctcttc	catactgtgg	aagctttgtt	ctttcactct	tcacaataaa
46021	tcttgctgct	gctcctcact	ctttgggtcc	gtgccacttt	taagagctgt	aacactaggc
46081	caggcatggt	ggctcacgcc	tgtaatccca	gcactttggg	aggccgagac	aggcagatca
46141	tgaggtcagg	agatcaagac	tatcctggct	aacatggtga	aaccccatct	ctattaaaaa
46201	tacaaaaaat	taactgggcg	tggtgacagg	cgtctgtagt	cccagctact	cgggaggctg
46261	aggcaggaga	atggcgtgaa	cccaggaggc	ggagcttgca	gtgagccgag	attgtgccac
46321	tgcactccag	cctgggcgac	agagcgagac	tctgtctcaa	aaacaaaaaa	aaagagctgt
46381	aacactcacc	gtgaaggtcc	gaggcttcat	tcttgaggtc	agtgagacca	cgaacccact
46441	ggaaggaacc	aactccagac	acaacaccac	aagaaacatt	gggggagagg	ccccccaaga
46501	ccctagtgac	tctaacctcg	ggagagaaga	aaggtcaagg	agtgaggtcc	ggatcactag
46561	cttgaggggt	gggagggagc	agcggaggga	cggaggaccc	cagtggccag	agctgccctc
46621	gtcagtggct	ggtgcctgct	ctcctcacgt	ctctctgcct	tgctcaggtg	acgagtctcc
46681	ccagggccct	gcacccacct	gcaagcattt	cagacagcgt	cacgggtgcc	tggaggctac
46741	ccctagacct	cgttctaagc	ctgcccagag	atgactaagg	gaggctcctg	catctctctg
46801	aaggggcagg	aggcaggctc	tggatgccgg	ccactcaccc	tctggctcag	gatagccctg
46861	gtggcagtct	ccttcctttc	tgctcatttc	atttcaatac	atcaagtacc	tcctctacat
46921	accaggctct	ttgctgggtg	gcagatgccc	ccaagcctat	cctggcaggc	ctgggcaatc
46981	agcactgtat	gccaggcgct	aggcccagcc	ttcacttgca	gggttaaccc	gccccgctct
47041	ggccacctgg	atccgtgaat	gaatgggaga	atgcggctgc	tctccagaga	acagcattct
47101	ctcaaccgct	tcttgtcgcg	ccagagatgg	cctcctcgaa	ggtgtgctgg	cagagctggc
47161	ctggcccagt	gggcagccct	gtgaggccgc	aggggtgagg	agccgccagc	cacaccacat
47221	ggctctcctg	gaacggagcc	Rcctgagccc	ggccaagccg	cctcgagcac	cagggcttga
47281	gtccattgca	ggcacaaggc	aaagaattgc	gacttgaggg	aggacccgga	ggaaggcagg
47341	ctggagggag	ggagggcggg	caaaggacag	cagggaaatg	aagggggctg	tgaaagacca
47401	gcaccagatg	aaagtaccga	gatgttccgg	acaggcctga	ttttctttat	cttcggggct
47461	gggactgcca	agaggccccg	gggaaagcct	gcaggcttca	ctcccaccag	aaccagcacc
47521	atttgaggga	cagatttcaa	tccttccttg	gccagacaag	caggcgggat	gccagcgctg
47581	gagaaagggg	aggaggagga	gcggtgggca	ggcctttcct	gctggaggtg	gacacgctgg
47641	gggcgctgag	gttcaaggcc	acacagtgag	gagtgcagaa	ccttaactgt	ctccttgcat
47701	cggctgatgg	cagagcttta	gttatagcca	tttcagggaa	atcctggtca	gttaaggttt
47761	tctagtgcag	ttgggatttt	cgcctatatt	tccaggtgcc	tctaaggtcc	tatggagcgt
47821	ccaggtttca	cagctggggg	agggacatct	ggttcccggt	catttatgtc	cccgctggct
47881	tatgcagggg	tgtcctgccc	ttctgcatct	ccctcaggga	cttggggaac	cttggatggt
47941	gtctttcctc	atactggggc	tgcagggggc	tcagaacact	gcctctgacc	cactattcct
48001	ccatgacaat	gataataaca	aaataggtat	tatttactat	gtacacgccc	tgttctaact
48061	gcttaacacg	tattaactca	cttaatcttc	ccaatacaac	ataaggtagg	tgctactgtc
48121	cccctcttac	agatgagaaa	gctaaggcac	aaaggtgaag	aacttgccat	gccacctctc
48181	ctccctgcac	tggaaaacgt	gttgtggggt	gggcaacagg	gctacagaga	gcccctcgag
48241	atcttgtagt	caggcctggg	gactaaagaa	ctttgtccca	acctctcatc	tctggagagt
48301	tttagggcta	ttttgagact	tgagggctaa	gaatgacctc	tttccttctg	agcctccacg
48361	gcctcccttc	ccaaagcagt	ggcggaggga	cacctgggtc	tcctgggctg	tggggtacaa
48421	tgcatagaaa	taaagtgggg	ctcggttgac	gtattagaca	tttataccat	tggggatgct
48481	ttattttata	ttttagcatt	atttattttt	attttttatt	tttctgagac	ggagtcttgc
48541	tctgtcaccc	aggctggagt	gcagtggcgc	gatctcagct	cactgcctcc	cgggcttcag
48601	cgattctcct	gcgtcagcct	cctgagtagc	tgagactaca	ggcaccctcc	accaggcttg
48661	gctaattatt	tttttatttt	tagtagagac	caggtttgac	catgttggcc	aggctggtca
48721	tgaactcctg	acctcaagtg	atccgcccac	ctcggcctcc	caaagtgcta	ggactatagg
48781	cgtgagccac	cgcacctggc	ctcatcactg	ccttttaata	aatgaggctg	tcctcttgga
48841	atctcaagcc	atgaaaagcc	ccatatggca	ggcagactcc	tgccaggaaa	tcaaattgat
48901	agtgtgggta	gtccccagct	cctcaatgtc	taccccaccc	tggacctcat	gggaagcatt
48961	cctggttggg	taaatccctg	aaacagtttt	ggccgggcgc	cgtggtttac	gcctgtaatc
49021	ccagcacttt	gggaggctga	ggtgggcgga	tcatgaggtc	aggagatcga	gaccatcctg
49081	gccaacatgg	tgaaaccctg	tctctactaa	aaacacaaaa	attagctggg	tatggtggcg
49141	aatgcctgta	atcccagcta	ctcgggtggc	tgaggcatga	gaatcgcttg	aacccaggag
49201	acagaggttg	cagtgagctg	agatcatgcc	actgcactcc	agcctgatga	cagagcgaga
49261	ctccatctca	aaaaaaaaaa	aaaaaaaaaa	aaagagtaca	gtttttcaaa	aacctgattt
49321	tctgatgtaa	acctgtgatg	gtctcctcag	ctgcctcaaa	cactgtcaca	tcctactgtg
49381	gattcaagct	gtcaggatgt	ttacacggcc	acctcaaatt	ccattccgct	ctctacaaaa
49441	acttattttt	agacgtgcac	tgtcccttct	tatacattcc	tcagtactgg	atcctggaca
49501	aatctttagt	caaccttaaa	gtttagttca	aaaggctcat	tttctcatag	agtttgaggc
49561	catttttgtg	agtggaggaa	cttgaggttt	taggaatttt	atttaaatca	tggagatatt
49621	ttcgactcga	atggctctta	actttgatct	tgggtctagg	ctgcctggtt	gaaactacta
49681	ctggttttct	ttcttttttt	ttttttgaga	tggagtttcR	ctgtgttgcc	caagctggag
49741	tgcgatggcg	caatctcggc	tcactgcaac	ctccgcctcc	tgggttcaag	caattctctt
49801	gcctcggcct	cccaagtagc	tgggtttaca	ggcatgtgcc	actatgcctg	gctaattctt
49861	tttgtgttta	gtagagttgg	gttttcgcca	tgttggtcag	gctggtctag	aactcccgac
49921	ctcaggtgat	ccacccacct	ctgcctccca	gtgctgggat	tacaggcgtg	agccactgtg
49981	cccagcgaac	ctactggttg	gttttcaaga	gttgcatcac	tttaactgga	acataNcgga
50041	agagtgggac	cagattttaa	ggtgagtcaa	gcctggcctt	cctaaaaccc	tattgactcc
50101	ttaattcagc	tcagggcacc	cctttgccgc	aaaaatctca	tcctttgaga	cccctaggag
50161	agggtgagtc	ggggaagcag	gggcctctcc	tagtctgaga	agtcttaaag	gcagggggga
50221	gaagtgccgc	ctcctcattt	catctttctc	tctcgttctc	ctctctctgc	cctttctctg
50281	tccctccctc	cattttttag	aaaatctata	gaggcaatga	gctttagcaa	atttatccag
50341	ttgtgtaaat	attgccacaa	agcagcttta	taacacctca	ctcaccccca	atagtcccct
50401	ggaccctatt	tgcagtcaat	ccctgctcct	ttcccagccc	ccagcaacta	ctgatctgct
50461	tgctgtctct	ctagttttgc	cttttctaga	aattgtgtaa	aatgaatcat	atactatgta
50521	gtgtttggtg	tctggctttt	ctcacttagc	ataacatttt	tgcatgtacc	gtagtttgtc
50581	ccctccatct	tttattatta	ttattattat	ttgtgacagg	gtcttgtagc	cttgtctaca
50641	aggctgcagt	acagtggtgc	gatcatggct	cactgcaacc	ttgaccccct	aggctcgtgc
50701	gatcctccta	cctcagcctc	ccgagtagct	gggcccacga	gggtatgcca	ctacacatgg
50761	caaattttta	aatttttttt	gtagagacag	ggtctcgcta	tggcccaggc	tgatttcaaa
50821	cttctgggct	caagcRgtct	acctgccttg	gcctcccaaa	gtgctgagct	tataggcatg
50881	agccaccata	actggccctt	ttatttttat	ttatttattt	ttgaggtgga	gtcttgcttt
50941	gttgcccagg	ctggagtgca	gtggtgcgat	ctcagcttac	tgcaggggtt	caagtgaatc
51001	tcatgcctca	gcctcccaag	tagctgggac	tacagatgtc	caccaccacg	cccagctaat
51061	tttttttttt	tttttggtat	ttttagtaga	gacagggttt	tgccacgttg	gccaggctgg
51121	cctccaattc	ctgacctcaa	gtgatccatc	ctcctcggct	tcccaaagtg	ctgggattac
51181	aggtgtgagc	caccatgtcc	agctctttta	ttgttttttg	gcttaaaaaa	caattttttt
51241	taaacaaaaa	cacacacaca	cacacacgta	ctcaaacaca	ctcgcacaca	caattttctc
51301	actaaccctc	tgaccttcca	ccccaagtcc	tgacttggtc	tttgggccct	aagatgcaat
51361	caggaaaaaa	agtgtggagt	ccacacccca	gttgggtcct	aagtgggtac	ctacaggggc
51421	agccaccatc	cagcctgccc	cagcccatgg	gggcccagga	tgtagcatcc	ccagtgatgg
51481	tgggagcaag	ggagaagtag	aggtgagatg	tgggctgtga	catgtgcttc	cctctccctc
51541	cagcttgaga	cccttggcct	ctgaccaagg	caagtgaaat	aaacatgaac	gaagctggga
51601	gaataatgtc	agtttactga	atgaatacat	ggctcgagtc	cattcagggt	ggagtgaggc
51661	ctggcaggtg	ccctcagcag	tgggacccca	ggccactgga	cctggcaggg	cttctgggct
51721	aagggggcag	caccaggcca	gcctgccagg	ggctccacag	tcccacgctg	cttgacctgt
51781	gctgtctggg	actagactgg	tcgctgtggc	tgcccataga	tgctcaagcc	agaccccaaa
51841	agagagtggc	acRaggtgaa	aatctaactg	tgaacgcttt	ggtttcagtt	tcagtaaaga
51901	ggaggaggga	gggaggcact	tggggacgta	gaaagaaggg	ctggcRggag	aggtctccgc
51961	cgagctccac	agttggcttc	cttgctagac	gacctggctt	tgagaaatgc	tgccttcatt
52021	tccatctccc	aactccgaat	ctggaaggca	agaaggtgtt	tcaggctgga	gggccgcagc
52081	agaccgtggg	tctgttacag	ggggcacggc	actgctgctt	catcttctcc	caccccatcc
52141	ctgaggccca	gccacccaca	tggccacagt	gcctggaacc	gtgtggggaa	cagagacctg
52201	cagtctgggg	ccggggaatc	cacagactgc	cccattgggg	tttcagccac	accagcttcc
52261	cccaaagaca	gcatcttggt	catctccacg	tccccacata	gcctggtgca	gaacttgttt
52321	tcaggctgaa	tagctgcagg	ggccattgct	tcctctcagg	gtaaggcccc	acttgaaccc
52381	ccgcttccta	atttggcagg	gaagggggaa	cggacccagg	tgtttcagga	gtctttcaga
52441	aatcaatggc	tggatgcaga	gggacaagtg	ataggacggg	gaaagggagg	gagagcaaga
52501	ggcactggga	cgcagtgcag	tcccagtgga	ggaggtggag	ttggtggggg	tgggtggtct
52561	cctttattct	tcggggaaac	tcttgtctca	atatgtttct	ttcccccttg	gcttgagtga
52621	atgctctctg	acaatttaga	aacagtttaa	gccaggcgtg	gtggctcacg	cctgtaatcc
52681	cagcgctttg	gaaggccaag	gggcgggggg	cggggggcgg	cgaatcactt	gaggtcagga
52741	gttcgagacc	agcctggcca	acatagcaaa	accccatctc	tacttaaaat	acaaaaaatt
52801	agccaggggt	ggtggcgggt	gtctgtaatc	ccagctgctt	aggaggttga	ggcaggagaa
52861	tcgcttgaac	ttgggaggca	gaggctgcag	tgagccgaga	tcgtgccact	gcacttcagc
52921	ctgggtgaca	gagcgagact	ccatctcaaa	aagaaaaata	aaaaaagaaa	aaagaaaaga
52981	aagaaagttt	ctgcctgttg	tggaagaaac	tgttgcacgg	agcaggagca	actgacatcc
53041	cctcaatcct	acctggaccc	tctcaccctc	tcagttctac	ccaaggaagc	ccaagcccct
53101	gagctgcccc	catcccctcg	tccatcctgc	gctttctcca	aaagccagta	gccttgactg
53161	ggtgtttggg	gaggtgctct	ggcccagcct	ttggccaagg	gccctcacac	ccgcccctgt
53221	tcctgcccct	gtcctcatct	gtttgcatat	ctgcaggagg	tattgccccc	actaccgacc
53281	caccacccct	tgtcttggtg	acactgggaa	gttatttgtg	ccactgggaa	gcagctgtcc
53341	tggtgctggt	tcctgggcac	acccagggac	tctccccagc	tgccctaacc	tcggtttcac
53401	ttgtggcatt	tgtgtgaggc	tttggttctc	acgtgcaagg	gaggggggcc	tggtcagcag
53461	gctggcatgg	gcaccacaga	gtcacaaaga	ggctggcacc	tctctgtgct	acctggtgtg
53521	ccctgatgtt	ttgcctcttt	tcctcctgtg	tacctcaacc	gagctagggc	agcaggtcac
53581	agctgtgact	cacctccggc	aacccatatt	aacaaagtgc	tgccaaccag	gcgagtcatg
53641	ccaggatgcc	aggggaccaa	gggagtgtgg	cctatggggg	aggctgggtg	cccatggctc
53701	tgccaatggc	taccctggct	cttgtcttga	gaacggctct	ggcgggaagc	caggccaagg
53761	ctgcgactgg	tcagcacccc	aggatggtcc	ctctgtgctg	ggttctcctc	ggcctcggct
53821	gtgcccaccc	gtgtctgggg	tgtgtgctga	gctgggggca	ggtggagatg	gcctgggcct
53881	ccaggggaga	actggctgtc	tccaccttgg	ggccgagagc	ggcaggggag	ggttggtgat
53941	ggggtggatc	ctccagcggg	tcccagttcc	cggaggaagg	atgacaaatg	agtgtgggtc
54001	gctccctctg	tgggaccatt	tgcctcggag	cagcagggaa	gggcggcagg	ttccctgcct
54061	cccgtggcga	ctcttttcgg	agcaccaccc	tagggatgtt	cttctgccct	ccggagacgt
54121	cggtcttccc	tggggccggg	gctcaaggcc	agggtgcccc	aagcccaggc	tccagggtgt
54181	gcggggaaag	gctcggtcct	gctcggcgcg	gctcgccctg	ggcactaggg	gtcgcccctg
54241	cccagcggaa	gccacgcggg	cgcgcccggt	cgccgcaggt	ttccccggac	cgggaaaagc
54301	gaggcgtctc	cggggcgggg	ctggggaggg	ggcgcctggg	cgcggcgccg	ggaccctgct
54361	gccctgtcct	cccggccgcg	gctggacgga	gcgcggggcc	gcagcaacca	ggccgggctc
54421	cccgtcgcgc	cccttccgga	gcgggaggcc	ctcgccgagg	cggaggctgg	gacgcgcggg
54481	gcgggcggcg	gcggggagcc	gcggggccga	ggcgcagggc	gttttccccg	gaggtgcggc
54541	gtgcgcccgc	gacacaaagg	tcttttaaag	acctcgcagc	gcccttcccg	gctgcggagg
54601	ctggaggccc	gggggggcga	ggccggggtc	gggggtggcc	gcgcgagggg	gcgctgggat
54661	cggccagacc	ccgcggttgc	gcccgggctg	gggctcccgg	gctccttttg	tggaaaagag
54721	cggaaagcag	ggccctctcc	gggtctctga	aaatggtcag	ttcggcttcg	cagggctgcg
54781	tgcccggaat	aataaattgg	cttctctagg	gtcgtaatct	gggccccacc	ccgagcagct
54841	ttgagctggt	tcgcgccttc	caggcaggac	tactgggagt	tctcaaaagc	acccccgcag
54901	tcggctgtgt	caggatcacc	tgggtccggt	gtgaacacga	ttccagggcc	ccaccccatc
54961	gcctgaagcg	gaatctctgg	gcggggccca	ggaaaccgag	tttttggtga	gttcccgggt
55021	gattctgatg	gcaaagccca	tgtgggagcc	actgttctaa	gggcttttgg	acaggcagtt
55081	gtgaaatttt	cccccagaag	aatctctggg	gacccagttg	tcacacaccg	ctggattcac
55141	tgcggtgttg	attctgcctc	ctgatgaagt	tcttcccgag	tctgacttcg	agcccgcctg
55201	ctttattaag	cacgtttttc	tccagtcgtt	tttttttttt	tttaatggaa	aaaggaacag
55261	ggagaaggct	tttctcgaac	ctgtttgcag	agagccgtct	tgcccgcttt	gagggccctt
55321	tcttgggaga	cctgtttgct	ttgttcaacc	tctgaattca	gcagacccca	aatccaccaa
55381	ggccactagc	ttgtgagtga	atgtggtccc	ttcaggtaag	ggccagacag	cccctgccag
55441	ggcttgggga	gggttttcct	agaggaatcc	tggcagtaaa	aaaaccaacc	cccaaactct
55501	ccaagtgctg	gacgctggag	aatcccagca	aggaaaagga	acaaatctta	tctcatgccg
55561	gaagataacc	tcttcccttt	gttggcgcct	ttccttgcgt	tcaggatgaa	ttaaaattct
55621	tatctgctct	gcatccagtg	aacttggcct	cgccttcctg	attgtttgct	gcggctgact
55681	ttcccaagct	ttgcggggtt	atttttgcct	ctgggtggtg	gtcattcctt	ccttccatgg
55741	catttggttc	cacacagtca	cagaaaaaga	gtaatttagc	aaacaccctc	aaaatggcag
55801	gactggcccc	caaaacctac	tttcattttc	ctctgttctg	ggttgtgggt	aatttcttga
55861	caactacaag	aaagaagaca	atgagaaatg	aattgttttt	tccaatacga	ttgtgaacag
55921	atgtataacc	tcctagtcgc	agcaacgttc	taggaatccc	ttacaccact	ttaaaggggc
55981	aggaaaatgg	gcagaggtgc	tgagggctgg	gtgagtgcta	agcattggca	gggctcagcc
56041	tcatcctgac	gagagctgca	gccataacct	gggtcacctt	tgctgtctcg	ggcttctaaa
56101	tttggcagcg	agaacagact	cgcttccttt	gagcaattga	tctgaatagc	agaatcccat
56161	tctgatggtc	cgaatcacat	ttacaggctg	tgggggtgaa	ggccgtgcta	attggccact
56221	tgcctcacca	ctggctttga	aacaatcgct	tgtattctct	gcgcggcagg	aagcagcaga
56281	cccatcaagg	ccctgggctc	actctttgtt	ctgactttat	ggcattttat	gccacaataa
56341	gaaacactgt	gtactccgtg	ggagcccatt	gtgccaggct	gcaaggatgt	gggctccggt
56401	gcagagggcc	tggtgctctt	ccccaggaag	aagaggggct	ttgtgacagg	ctgggggaca
56461	aaacaagggg	tgctggacac	tgttactgag	gcaactgcct	ggccagtgtg	gaggcagctt
56521	tagtccctgg	gaccgtttct	gtgcccaagg	agagggaggg	caggggaagg	atggaatttc
56581	atctagagta	gcaggtcctg	gttgcctggt	aaattatgca	tcaggactgg	gctagccact
56641	gcctccgttt	tctctgggct	cctgagataa	cctccacctg	cctctagatt	ctgtgccagc
56701	tgatcgttat	ctatctcatc	aactcttgtt	ccatcaggaa	actgcatctt	ggtgagtggg
56761	aagtttttgt	gactgtggac	caaacctggg	cttcccatat	tttgggttga	tctgggcctt
56821	ggagggaaga	gctttcggtt	ttgtagaaat	gatgtggata	ggaactgggg	taggcacagt
56881	ccatccagtc	tcacacgtga	atgaaccaac	ggggatttga	gaatggcttc	tagatcgtac
56941	ctgcccctcc	ggccagcccc	ggggctccct	tcccctgcac	ctagcctgaa	gttttccacc
57001	attaacggca	cacctggggc	agaagacaga	gtagggtcct	tgctccagga	gatcgttgta
57061	ataatcagat	agagacaaga	cctgagctgg	gaggaagcca	ggacacgggg	gatgggggac
57121	caggccctga	caaacggagt	gctccgtgtg	ggggctgaaa	gggaaggagg	agagggaagg
57181	cagggccatt	tagcttcacc	tcaaaggtgg	ggtaaagtga	ggctggtggg	tcctgtcttc
57241	tctggagatg	ctccccgatg	ggaggaaagg	ccagcttcct	gccggccact	tgcagaagcg
57301	agcatccagt	gcttccgcca	gcctgtccct	caccccagac	ccagccctgt	ccttcccatg
57361	tctgatgctc	ccacacgggc	ccccttatta	ccccgtgcca	ttgcagcagc	ctcccggctg
57421	gtttctttcc	cctgcaatgt	ggctgcccaa	gttctcctcc	caaaacccac	atctcctggc
57481	ctgccaatcc	caggctggaa	actgttccat	ggcctccaga	gccgctcaca	aacccttccc
57541	gccccactcc	ctgcctgcac	cttaggctca	ttctctgccc	tccctggcca	cacacctccc
57601	tgactttccc	caaacatgca	ggtctttcca	tgtctctgtg	cgtttccatt	tccctctgca
57661	tggaacactc	tttcccatca	cacctaccct	tgcccatctg	ccaaaccctc	caggattctg
57721	ggtcaacatc	atccccacgg	tggatccatt	ggtgagagca	ataatgaagc	aggtttgcca
57781	ccaggctccc	aaagaagtgg	gaacactgac	tgcaaagggc	acaatctgat	tggatgaaaa
57841	gcgaggcctc	agaagcattg	gcaYgtgtcc	gcgaagagcc	tagctggagg	tctgtcctag
57901	aggaggggct	gaaggagggg	cgagaatggc	agcgctccat	ttcatccgac	tgctctgtgt
57961	tcctcacatc	tgacccaacc	ttccgttaca	acacaggcac	atttgtggat	actcttggtt
58021	acatgtgtgt	tctctcctta	gattctgagt	ctcttctagg	aaaggagtgt	cttaatcatc
58081	tttgtattcc	cagaagctag	tttagaggct	agtatgtagt	aggttcgcag	aaaatctttg
58141	aatagcggct	gaggtgggaa	gatttcttga	gactaggaat	tcaagaccag	cctgggtaaa
58201	ctagcaagac	ccccatctct	acaaaaaata	aaaaattagc	caggtgtagt	ggtggatgca
58261	tcccagctcc	tcaggaggct	gaggtgggag	gatcacttga	gcccaggcat	tcaaagctgc
58321	aatgagctgt	catcccgcca	gtgcactcca	gcctgggcaa	cagagtgaga	ccctgtctca
58381	aaaagagaaa	gaaaatcttt	gagtaaataa	atatatgttg	aacttggaag	tattccttta
58441	cctagaatat	tgttctctgc	aaattttgta	ctatcacttt	ctccaaaaca	taactcagga
58501	ctcgcctcct	ggaaaaagta	ggttcttttt	tttttttttc	tttttgagac	agagtcttgc
58561	tctgttgccc	aggctggagc	gcagtggcgc	cgtctcggct	cactgcaagc	tctgcctccc
58621	gggttcacgc	cattctcctg	cctcagcctc	cccagcagct	ggggctacag	gtgcacgctg
58681	ccacgcccgg	ctaatttttg	tatttttagt	agagacaggg	tttcaccgtg	ttagccagga
58741	tggtctcgat	ctcctgacct	tgtgatccac	ctgtctcggc	ctcccaaagt	gctgggatta
58801	aaggtgtgag	ccaccgcacc	tggccaaaaa	gtaggttctg	attcagtagt	tgactgtgca
58861	tcagaatgtt	actaagcacc	tattaggtac	taggcatttt	ctaggcactg	gaggcctgtg
58921	agatataaaa	gagataaagg	ttcccgtgcc	caagttgtta	atgagtgccc	ccaacccatg
58981	caggccactt	ccttatctgg	caaaatcatt	tgggacgtca	gtaaacactc	aatgttcctg
59041	gtatccatag	tgccagggac	atggtcagca	gtcagatgtg	actcactgtg	ggcccagcat
59101	cataagaggc	aggcatagaa	ggcctggctt	tgcattcata	tagctcacaa	cttcactgag
59161	gagaccagtt	gtttatggga	ttgcaggaaa	ccccaggaag	ccccagccag	ggaagagctt
59221	atgttgtcaa	attcacagcc	tgtaggaatt	cactgggtcc	actagttctc	ttgcacaggt
59281	gctactttcc	agttatttcc	tggttttata	aatatgtgtc	tcctctttca	actccttgac
59341	aagctcttta	cggaaaggga	catcagggcg	tcatgtctag	cgtctagtag	cttctttccc
59401	tgatcctcat	ctcYgcacct	ggtacagggc	agtgcatgaa	tggatgacaa	atgatcacca
59461	ccattaacag	gcatttgtca	gccgggcacg	ggggctcaca	cctgtaatcc	cagcactttg
59521	ggaggccaag	gcaggtggat	cacctgaggt	caggagttcg	agaccagcct	gaccaacatg
59581	gtgaaaccct	gcctctacta	aaaatacaca	aattagccgg	gcacaataca	ccgataatcc
59641	cagctactca	ggaggtggag	gcaggagaat	cactggaacc	cgggaggcag	aggttgcagt
59701	gagctgagat	tgagccactg	cactccagcc	tgggtgacag	agcaagactc	ttgtctcaaa
59761	aaaataaaac	aaaaaaacaa	aacaaaaaaa	acgaggcatc	catcactggg	tctcttcatg
59821	agacacaacc	aagaaacaca	atgtgagtga	attctccagt	tctggtagat	gaaggagagg
59881	gaaggagggc	ttctctgctg	acttagtgcc	tctcttttgc	tcaatgttac	catcagattc
59941	tgaatgtttt	ctacgagaaa	ttactgagat	gcaaatcaag	aagtgtgaat	ttaacaagag
60001	ccagttggtt	tcctactttc	atttgggtgc	ctttttttgt	tttttgtttt	aaacagggtc
60061	tcactctgtc	acaYaggctg	gagtgcggtg	gcaccaatca	tggctcactg	cagcgtcagc
60121	ctcccggcag	catcaacggc	accgggcctg	ggtgcctctt	aactggttat	ctgtacctgt
60181	tactgctcgg	tggtctaagt	gggtgagatc	aatttcaggg	tttctccagt	tcaatgtgag
60241	cttgtggtga	gagaagagtg	tccctggtcc	ctcctgctgc	tttttgctct	ggttcccagc
60301	ttgctccttg	caacttcttc	ctagtccagg	acagatttac	tggaagtttc	tttagaggca
60361	gtgctttagg	gctttggtct	tcatctgttg	ggttgtactg	tttgtcgttt	gtcatgtttg
60421	ctttgcaagc	ctggtggcta	atgttgcttg	cattggctca	ctgctcttgg	ggccatctgt
60481	aacctgtatc	aaccccggat	gctttgaagt	tcagtgtgca	ataaaaagtt	cattaaaaag
60541	atgtggaatc	atgaaaataa	ggttacagaa	atgttaacaa	aggatcatat	cctgcttctg
60601	gtacttttct	tttttaaaaa	atgtatttct	ttgagaaatt	tatgtcagca	tttaaaccat
60661	ggaagagttt	aggaaggaca	ggcctgggtc	aaaaggaggg	tgagattctt	gaggagatat
60721	cttggcagag	ccccagcctg	ttgtcttaat	tgagagctca	gggtctaagg	agagaatgtg
60781	agccagaaaa	aaaaaaatct	aggtttctta	tgactaacag	tttgaaccca	gctttttttt
60841	tttttttttt	ttttttttga	gacggagtct	cattctgtca	cccaggctgg	agtgcagtgg
60901	cacaatctca	gctcattgca	acctctgtct	tctgggttcc	agcgattctc	ctgcctcaac
60961	ctcccaagta	gctgggatta	caggcgtgtg	ccaccacacc	cagctaattt	ttttgtaatt
61021	ttagtaaaga	cagggtttca	ccatgttggc	caggttggcc	tcaaattcct	gagctcaagt
61081	gatcctctag	cctcggcctc	ccaaagcgct	gggattacag	gcatgagcca	tcacacccag
61141	ccaggttcct	ctttttcgca	ggtcctccat	gttcgggtgc	ccacacgtaa	tacacaacca
61201	gcccctgcat	ccttgctctc	ctctattttt	ggggggcaaa	tatcctagag	gctcattcgg
61261	ttatatgacc	attgatgacc	atttaattac	tactcatgtt	taataataag	caattatgtg
61321	atcgtcactt	acttttcagc	cagagggtca	ccatgtgtac	acttagcagc	tgctaaatct
61381	tagtcctaac	aatgatagtc	ccatatcctc	ccaagcgacc	gtgaggacct	caacagcttg
61441	cacatctaat	aaacagcact	gcagggtttt	cagggctgcc	accggacagc	tctgggtcac
61501	agccagactt	accctctctc	tttccacctg	gttgtggttg	agcctcatga	gttctgcaaa
61561	cctctgctca	tagaggtgaa	gcagcagcac	caggtacaag	cctgaattca	tcagctcgtt
61621	ttgtgcctac	aaatggaaaa	gaaagctctt	cagttcatct	gtaaaatagt	catggtctaa
61681	attgtgggat	gcagggtaac	aaggctaaga	ggtgacaaga	actgggagaa	gagcccaagc
61741	tccaaggcaa	ggcctgctct	tggggaccag	aagacagagc	aggaggagat	ccagggtaga
61801	ggccagggca	gccactcccc	tgggattttt	tactagctag	tggaggatgc	tcggagaaag
61861	ttccattttc	caggctcaat	cccattccac	atttattgag	cagttacata	tgcaaagcct
61921	tgagctggat	gttgtgggga	acacagggca	aaaagcctca	gaactccctg	ctgggaaccg
61981	atcacctggt	gtgggggaga	gagcttcatc	ggtaaacagc	tccagtacaa	gctggatgtg
62041	tcgggtgcta	caacagagat	gcaccaggcc	ttgtccataa	cgttctcagc	agtcacagat
62101	gtccccttgt	gaaaggcttc	ctgaggagcc	tcctttgccc	ccatcattcc	tttgcttccc
62161	agtccctaag	cattcgtctt	gatcttgcat	atcacctttt	gcacttgtta	acgtttccgc
62221	tttctcttga	ggagtgggct	gtgctttttt	tctcgctggt	gctcagaaca	ggcgctacac
62281	agggaggatg	tgatggtctg	gctgcccatg	gcacttctct	gtccttagca	cttgggcttt
62341	gctgccaaga	gtggctgtgc	tcactctaga	cctttcacag	accttccata	aatcagtggt
62401	attagtaaca	actactccta	tccctctata	ggggaaggag	gggaaggccc	tttcagtccc
62461	catctttccc	ttgagtgggg	gtcttgggat	gggccaggct	gtgctcacaa	agccacccag
62521	cccccgggga	atagagtccc	cagcagaggg	catggcccct	tccgtcaccc	ttgggaaagc
62581	ttgcaactgt	gactctgtcg	gcccaggata	acgatgcgtg	ggcatgaatg	acacagtgag
62641	cactcagtgt	ctcatctgcc	ttcttcctgc	agcagcgcgg	gtgccacatc	ttcctgttct
62701	cattagatcc	agggcagctc	aggaggttgg	cacagaaccc	acctctccca	ggaccaagca
62761	gctgccagaa	aaggcacaga	agttgagcaa	ggattgatat	gctcttcctt	ctgaatcagg
62821	gccaactctg	gatcttggtg	acagccggcc	ctgagatcac	tgctgcaggc	ctctccacca
62881	ttctacagat	ccatcttcga	aggccccagt	cctctgtcct	tagcagttag	cctcctattt
62941	ttagcctttg	gtcgtgtttt	ttgtgctctg	ctgaccttgg	cctagagtga	gtagagaaga
63001	agttgcttgt	ttgcattatt	tctgttttat	ttatttaatt	ttatttttga	gacagacaca
63061	gtcttgccca	ggctggagtg	caatggcgtg	atctcggctc	actgcaacct	ccacctccca
63121	ggttcaagca	attctcctgc	ctcagcctcc	tgagtagctg	ggattacagg	tgtgcaccac
63181	cacgcccagc	taatttttgt	atttttagta	gagatggggt	ttcatcatgt	tggccaggct
63241	ggtctcgaac	tcctggcctc	aggtgatcca	cctgccttgg	cctcccaaag	tgctgggatt
63301	acaggtgtaa	gccaccctgc	ctagccactt	tttctgtttt	aattgcctcc	tcctgccctc
63361	cccgtgagtc	tgtgcctgcc	tccgactgtc	tcgccaacca	cctcttctga	gaagccttcc
63421	tcacctggct	tttagctcct	cctcaccaac	aaagccttgg	tccttatttg	tttacctcat
63481	ccccggcttc	ctcctgcaaa	agctgccagt	ggttctctca	ccagtgctct	ttgccagcca
63541	gcttttatgc	ttgagacacc	gggatgcatg	atgacaaatc	aatcagctag	aaaatggttt
63601	ggaactatca	ggtttgtcaa	agcattcagg	aaaatcattt	actttttatg	actcaataag
63661	gcccagaggc	atgcagatgg	gagaatatcc	actaatgttt	tctgcagata	atttgaaaag
63721	tcacttctag	cagattgtgt	ctcttctctg	atctgtggga	gggaacctgc	cacacagtgc
63781	catcaatctc	gccggctcgg	ttcctttatg	tgcgcccttt	gcagagctgg	tgatgctcga
63841	caaaggggct	cagcccacca	atcagagcag	gcgtgtgata	gtcaactccg	aatcagcctt
63901	tacactcctg	agctacaagt	gggagggatt	tgttaactca	aagagttcca	ccgcacttgg
63961	ctggccaggg	ccaaatgaac	gaggttttgg	agcagggctt	actggagcta	cggcccatcc
64021	accccttcct	tgtcccaatc	acatcacact	ttgactccca	cgtggagttc	cctttgtgtg
64081	ccagactgaa	gggaatgggg	gtggcattaa	taggaggggg	cggggacatt	aaaaaggaga
64141	aggcatgtga	aacagcgcaa	aagggctccg	gagatctcag	cccacctgcc	agctgttttc
64201	tccattttgc	taatattcat	ttaggccaag	agacttgcta	ctgacggaaa	ttctcaatat
64261	attccactta	aagaagctga	cagcctggct	gaatgttcta	tcaagtcttc	aaatatattc
64321	aagagtgctc	ctaggtataa	gggtgattag	gtgactgcgt	gtgtctgagg	acatctgtcc
64381	ttggctgaga	tggagccagg	ccaggcctgt	gcttcacagc	aatgacagcc	tgaggcccac
64441	tgagactctc	ctgtgcggca	gagcaaggat	ggcaggggtg	tgttccaatt	cagtgagcag
64501	gggcccctgg	agtgcatctt	acctggaaag	cgctgccggc	taaggtgggc	agtgcagggc
64561	caccggacac	tgtgacttta	ggcagagttt	taactgtgca	ggaccaaagg	gactcaattt
64621	gtaatggaag	ggaagtaacc	tctgttctgc	ctgtttcctc	aaagcatgat	agtaaagtga
64681	gctaatatat	gggatctcgc	aacaccaaca	catcctacaa	gagacaagat	ttaaagacag
64741	gattccaggt	aaattgtctg	ggcgttaaga	tctgtgaggg	caagacctgc	atctgtcttg
64801	tttgctcctg	actcctagtg	cctggcccag	tgcctggtat	actgtgcatg	ctttataaat
64861	atatgcacag	atgaagcaat	gagaaaaaaa	tgcataattg	tgatggatca	gacagtgacc
64921	cattcagcca	caacttttga	atctagtggc	tccaggttta	acatgcatca	gaaatactga
64981	gcaggccttt	tcaaacacag	ttgccaggca	gtcccgtccc	ctcccctccc	ccttctcctc
65041	tttttttgag	acagtctcac	tctgttgccc	aggctggagt	gcaatggtgt	gatctcggct
65101	cactgcaacc	tccgcctccc	aggtttaagt	gattctcctg	cctcagcctc	ccgagtagct
65161	gggatttcag	gtgtgtgcca	ccactcccag	ctaatttttg	tatttttagt	agagacgggg
65221	tttcaccaca	tttggccagg	ctggtctcca	actcctgacc	tcaaatgatc	cacccacctc
65281	ggcctttcaa	agtgttgcga	ttacaggcgt	gagtcaccgc	gcctggcctc	actgctcctc
65341	ctttcctccc	tgcatttctg	attcagctgg	actggagtgg	gcccaagaat	gtgtacttct
65401	aacaagttcc	cagatgatgc	taacgctcct	ggtttgggga	ccacccattt	ttgagaacca
65461	ctgatctaaa	ctaagggtga	gcacgtggta	gctgctaagc	tgaatctggc	ctgtggatgt
65521	gctctggttg	gatggaagga	agcaagaagg	aaggtagaaa	agaagagcat	gaccatcttt
65581	agttggggag	agcactttcc	attttgccac	aaatgccacc	acgcccaatg	gcaggatacc
65641	tagaagatta	ccatcatttg	ttgtctgcct	ggcctctgtg	gtatttgagt	gtgtaacctg
65701	tgacctaagc	tttccttaaa	Yctgttttca	cctcatccat	tttggaggct	agaatgttat
65761	ttggctcgcc	gcatgctgct	gtccaggagt	tctgccctcc	accgcaaaac	cgagtgccca
65821	accagcatcc	aatatgagtc	ctgcttccag	gcgacagcca	acgctcacag	gagcaaatgt
65881	aggcttgcct	cacacacagc	actaccgaaa	gagtcaggag	aaaggagggc	tgtactgcca
65941	caggccctga	cagacctaag	atgaaaccgc	caggtccctg	gggtcccaca	gctgctcttg
66001	tctaatgatc	ccctctccag	atgcttgtag	gagttcctga	tctagccgct	tgaggcctgg
66061	taacagacct	tgaccttggg	cctcatacta	gaataatccg	agttcagtgc	cctgttagca
66121	cctgtgagca	gcatctgccc	tgctcccacc	agaagtacag	aactaaggta	ggaaaacgtg
66181	ctctgacggg	agcccctcca	cactctcaaa	ggccaccgac	agtgctgacc	cggcacctag
66241	aggacacgcc	ctgatctgtg	ctcaggtccc	aggggaggcg	tccgtcccag	atgtcacaga
66301	cttcactcca	aggcccggtt	gatagaaggc	ccgctcctct	ctttccttcc	gctgttaaac
66361	atctcttctt	cagaaaggcc	ttctctggtt	cagagagcaa	gtcggagtcc	cacagctgtt
66421	cccgcagcgg	cctgcatggt	ccttgttttg	acctccacct	gcaggaattg	ctggcttcag
66481	tcttcgctgc	tggtcggtag	ggccctgcgg	gtcttgggta	cggcagcatt	ttcggcacag
66541	tatctcacag	gcagcaggtg	ctcaataagt	atttgaaaat	ttagttaaac	tggctgggtg
66601	tggtagctca	cacctgtaac	cctagcactt	tgggaggcca	aggtgggaag	atcacttgag
66661	cccaagattt	tgagaccagc	ctgggcaaca	aagtgagaca	gaccccatct	ctcaaaaaaa
66721	aaaaaaaaga	aaaaaagcag	ggtgtggtgg	cacacacctg	tggacccagc	tacttaggag
66781	gctgaggcag	gaggatccct	tgaacccagg	agggaccctg	gccccatccc	agagctgggg
66841	ttagacctgg	gttgggcctg	tgtatcacca	ttttaataga	aaaaaagaag	acctgcagct
66901	aaatgttata	agttatcatt	ttgggtggta	aattataaga	aatttttgta	tggtttttgt
66961	aattaaacaa	aagcaaaaaa	aaaaaaattc	taagtgggaa	aatatataag	aaaaacagtt
67021	cactagtcag	ttagtttgag	gttaagtgag	aaccaggcta	agctgaagcc	cgttctaggt
67081	ttcttttggt	tttgcccctt	ttttggtaca	tgtctagact	tgtacacgtc	tagaagtggt
67141	gccacttctc	cagaaaggaa	cccatttgcc	aaggacaagc	agcaggaggg	tggccaggag
67201	gcccaggtga	gccaggtttg	gaagcgaggg	gaagggacca	ggcccacaag	gcacaggtgt
67261	ccatgtcacc	tccacggcca	ggctggtggc	ctcctcagct	gggcttgtcc	cctcagtggg
67321	ctcaccgcgc	ctcggggacg	agctgagttt	cagtgacgtt	gtagatatct	ttgtgttcaa
67381	caacagttgc	ttcagtcttt	atctatggcg	agcttcagaa	ttcgcccaag	tcaggctccc
67441	tggggcctgg	ggtttcgccc	aggctgtgag	cagacaggca	ctatgaattc	ccagcaggtc
67501	atggggacag	tcagggctgc	agtgaggtgt	gagccctcag	ccgcctccag	acagcagccg
67561	cccatgctat	gacctggctc	tccccacagg	gcgggcctgg	cagcctagct	gtcacctggg
67621	atgataatgc	gggcatttcc	caaaggctct	gatggcttgt	gaagttctca	ctgaaacgaa
67681	tttaaaatca	ttcctgcttc	cacgtggagc	aatgactgtg	ctggatgctt	tctgtctctc
61741	ctgcagatcc	gcacccctcc	tgctctgtgg	cccaggggcc	ggccccatgg	ctttccccag
67801	ccgggcttcc	ttgccctctg	gcttcccgtt	gggtttggcc	catgggaggc	cccggcagga
67861	gacccgaggg	cggaggaggg	agaagctggg	tgtctcttcc	caatccctct	ctgctgggcg
67921	tggtgtgaca	gtggttgctg	tcttctcctg	aaggccacag	gctgctggtg	gctgatcctt
67981	agctacagcg	ctcaKgaccc	tggccacact	gctagtccca	ggacgcctcc	tcgttccttg
68041	ctgctttctt	ttgctgccca	gatttccctc	ctcccttctg	cgttcttcac	ttgccccctt
68101	tgagtgtgcc	accatctctt	cccacccaga	tcctggctga	tacaattact	gtcatagttc
68161	tttctagaag	gtgcttgtag	ccagttgtct	taacatggag

Following is a CDK10 genomic nucleotide sequence (SEQ ID NO: 4).

>16:89456451-89555700
1     gttaggaagg gtgcagtatt ctaaagtgta ctgcagacgt gtgtaaacgc catgcctgac
61    acacactcaa gcccccacgc cagccggagc aggacggggc agcagcaggg cggctcgctt
121   gggggcggct gcagctgggg cctctgagtc gagatcaggg ctccctggtc ggagcctcag
181   cccaagctct cctccagcct ctaacccaca accctctctc ccttcccaca gcaYcagagc
241   gtggggttgg tgacacagcg tttcggggac cgaccctacc tccgtgacag ctggtcctcc
301   tggctgcgca cagagctctc gcccacggca gaggcgccct cgggcagctg gctgagctgg
361   tccagcacct ccaggccatt ctcctcggcg atctgcatga tgaggctgtc cacctgctcc
421   tgcggcgtgg tcagggtggt ggccgagctc atggagtcct ccatcacctg ggggcagggg
481   catgctctgg acaacaggtg gggccaggcc catggggcYc cactcagctt cacaagggta
541   cgactgcact tttcgttccc tcacacagcc agccaccttc ttgccctgtt ctctcagtga
601   ctctctctgt ctcaccttcc accaggagcc tttcctgccc ccccacccag ccccaccctc
661   tgactgtgcc atgcctgctg ccgcgggtgg acatctttcc acacctctgc atgcttgtct
721   gccatccgag cctccccaca aggagccagg tgcctgcagg aggcccccgc cgccctgccc
781   accctacctg tcagggtcct ggcagggacc cagcacagag gatgcttggt gacgtcaggg
841   agcaaccaca ggtatgcaga gacagcacgt cagcctgtga gccacccctc ccgatgagct
901   gcccacacac gctccttgtc cccaggccac agccccaagg gtaggggcca cataccgatg
961   tatggacgtc caggttctgc acctgctgct cgaacctgtc catcactgag gagaccttct
1021  gcaggtccat ggtgctcagg gccttgtcca gggctttggt cacctgggcc atattcttgg
1081  tcacctgaga caggagagag cgcaggaggg aacaggatga aaggcaagtg gagctcacgc
1141  accagggacg ggtcccctgg actctgacag gagagctggg gcaccccaac cctgacccac
1201  aaaaccccaa ctctgggctg agccatcatc tgggtcctat ggaaagacca ccaactcgac
1261  ggaaaaggcc atggagaccc agtgcggggt cagtggagaa aaggccgccg acgtggagac
1321  ccagtgcggg gtcagtggag aaaaggccgc cgacgtggag acccagtgcg gggtcggtgg
1381  agaaaaggcc gccgacgtgg ggacccagcg cggggtcggt ggagaaaagg ccgccgacgt
1441  ggggacccag cgcggggtcg gtggagaaaa ggccgccgac gtggggaccc agcgcggggt
1501  cggtggagaa aaggccgccg acgtggagac ccagcgcggg gtcggtggag aaaaggccgc
1561  cgacgtgggg acccagcgcg gggtcggtgg agaaaaggcc gccgacgtgg agacccagcg
1621  cggggtccgt ggagaaaagg ccgccgacgt ggacacccag cgcggggtcg gtggagaaaa
1681  ggccgccgac gtggggaccc agcgcggggt cggtggagaa aaggccgccg acgtggggac
1741  ccagcgcggg gtcggtggag aaaaggccgc cgacgtgggg acccagcgcg gggtcggtgg
1801  agaaaaggcc gccgacgtgg ggacccagcg cggggtcggt ggagaaaagg ccgccgacgt
1861  ggggacccag cgcggggtcg gtggagaaaa ggccgccgac gtggagaccc agcgcggggt
1921  cggtggagaa aaggccgccg acgtggagac ccagcgcggg gtcggtggag aaaaggccgc
1981  cgacgtggag acccagcgcg gggtcggtgg agaaaaggcc gccgacgtgg agacccagcg
2041  cggggtcggt ggagaaaagg ccgccgacgt ggagacccag cgcggggtcg gtggagaaaa
2101  ggccgccgac gtggagaccc agcgcggggt cggtggagaa aaggccgccg acgtggggac
2161  ccagcgcggg gtcggtggag aaaaggccgc cgacgtgggg tctccaggac tgctgtgccc
2221  tcctggccca cctgcactgt gtgaaggaaa tgcctgcaac agccaaggct ctgctgtgac
2281  gtccctgacc cagcagatga gcctggccat gcaggctctg cctcttgtgg gagttgccaa
2341  gaccgaggcc tggccaggta cagtgacagt gagtggttca cgcctataat tccagcactt
2401  tgggaggccg aggtgggaag attgcttgag gccaggagtt tgagaccaga gcggccaaca
2461  tagacacect gtctctacat aaaaatgaaa aaaatcagct gggcatggtg gtggatgcct
2521  gtggtctcag ctacttggga ggctgaggca ggaggatcgc ttgagcccag gaggttgaga
2581  ccagagtggc caacatagac accctgtctc tacttaaaaa tgaaaagatc agccgggcat
2641  ggtggtggat gcctgtggtc tcagctactt gcgaggctga ggcaggagga ttgcttgagc
2701  ccaggaggtt gaggctgcag tgagctgtga ctgcaccact gcactccagc ctgggtgaca
2761  gagcaagaca gtctctaaaa aatatatatt taaaaaaaaa aaagcccaag tcttatcaag
2821  aggtccttcc tggggcatca gtgcaagctc agggtgcagc ctcacctgtg tccctgccag
2881  catttcccac cccacgctga tccagcttaa ctcaacctcc ccaccccacg ctgatccagc
2941  cctcaacctc cccaccccac gctgatccag cttccctcaa cctccccacc ccRcgctgat
3001  ccaccttccg tcaactctga gctgccccag atccagaccg cagagcccat tcctgcttca
3061  gccagcgaac gccacccatc cagcaccagg gcccagcact cacccccttc atagtcacag
3121  ctgtctgcac cttggaggcc actgcgtcta cgcgggacgc catccgaagc cagttcacac
3181  cttcgttctt cttgcggatg gcgttctcgg catacacacg ggcacactct acatttttct
3241  gcagaagggc ctgaaacccg Sgggggaaag cagctggaag agcttggtgg tgtgtgtgcc
3301  ccctgctagg agcccagttt ttgttttgtt ttgttttgtt ttgtttgaga cggagtcttg
3361  ctctgttgcc caggctggag tgcagtggca cgatctcgac tcaacgcaag ctccgccccc
3421  caggttcatg ccattctcct gcctcagcct cccgagtagt tgggactaca ggcgcccgcc
3481  accatgcctg gctaattttt ttgtattttt agtagagatg gggtttcacc gtgttagcca
3541  ggatggcctc gatctcctga cctcgtgatc tgcccgcctc ggcctcccaa agagcYggga
3601  tcacaggcgt gagccaccgM gcccggccct aggagcccag tgttgaggcg gtgggcgggc
3661  ctctccccag aaatgtttga gctaaaaatg caaacaccca ggccccagcc cagcccccca
3721  agcaggcttc tgcttccccc cgcacccctc cagcactcca ctgggcacgg gacacagcgg
3781  gtgacactca gagcctgtgg caggcagttc tccgagctcc attctccctg ggagcctggc
3841  tgtgggtgaa gagttaccaa agtccaatac gctgggacct acttcaccga ttacgcagtt
3901  ttaagagctg cacaagatcc taccttcttt tctttttttt ctttttttgg agatggaatc
3961  tcgctctgtg gcccaggatg gagtgcagca gtgtgatctc ggctcactgc aacctccacc
4021  tcctgggctc aagcaattct cccgcctcag ccttccgagt agctgggatt ataggtgtga
4081  atcactgcgc ccggcctaga tccctcctct ccttctgccc tgtccatcat ggggagggga
4141  cccctcctgg agaggcaccc ctgtaagcct ccagccccat cccaccccat ggggcagggg
4201  catcatgact ctgcccagac cctgatgccc tagacaccag ctctgtaggg aggagagags
4261  taaaaatgat aggatccgct gggcccagtg gctcatgcct gtaatcccag cactctggga
4321  ggctgaggca ggtggatcac ctgaggtcag gagtttgaca ccagcctggc caacacggcg
4381  aaaccccatc tctactaaaa atacaaaaat tagccaggtg tggtggcgca tgcttgtaat
4441  cccagctacc caggaggttg aggcaggaga atcactcgaa cccaggaggc agaggttgca
4501  gtgagccgag accgcacctc tgcactccag cctgggcaac agcgagactc catctcaaaa
4561  aaaaaaaaga taggatcgtg gcagacagct agctagcagc cctcctcctg cagatggcaa
4621  aatcaagttc agaatgttgg aaatgcaaag aaggaaaaca atgaaggcaa tgcactcatc
4681  tctgtgctct ggacgccctc agtgggctgg gaaggtctgg caggggctgt agggcaggga
4741  cRgaaaccat tctgggctgc accacacaca gcacctccct tcctgagtgc ctgtttgtct
4801  tatgtgggaa gcaaatactt tgaggctcag aaatcatagt gaggattagg ctgggcacag
4861  tggctcatgc ctgcaatacc agcacttttg gaggccaagg caggtgggtc acttgaggat
4921  aagagttcga gaccggcctg gccaacatgg cgaaacccca tctctacaaa aaaattaaaa
4981  aattagctgg gtgcaagcct gtaatcgcag ctacgtgtga ggcgaaggcc ctagaatcac
5041  ttgaacccgg gaggcggagg ttgcagtgag acgagatcgc acctgtgcac tccagcctgg
5101  gcgacagagc aagactccgt ctcaaaaaac aaacaaacaa acaaacaaac aaacaaaata
5161  tatatatata tgtacctcaa ggtgacgatt aaatcatgat gtagaaagtg ccctgcccct
5221  ccccaaaagg catcaaaaca aaacaggaca caaaaataag ggcagaaaag gacagaagac
5281  aaaccaggag agtcatgacc ccacagcccc cagggtctca ccttcttcac tttggcctgc
5341  tccgccttgg agtccttctc cgccttcttg gccagcttct ccagctgctt cgccgtgaac
5401  tgagcggaag ccggaatgtc ctgggtcaga catgcggagc ccatccccca ggcccggctc
5461  tccacacccc cacacctgtg cccacacctg tgcccacaca ggttcctaag cccccatcag
5521  ccagcctggg cccagcacac cgcagggaag gcgtgaagcc tgtgggcgtg catcctgggc
5581  ggcgagagat ggcaccagct ggaggaggaa gctgcctgct ctgcctcagg ctctgtctgg
5641  gttttctcca gtgtctgtct tctctgtgaa cagcctcacc caaggcctcc tccagagcgg
5701  aagggtcaaa aacctctcac tctgatctcg gctcctgctt atggatggct tttcaacgtc
5761  aaagaaagac tgaaggaaac tcatttcagg ctacccccaa gtcataacac agaactccag
5821  gtaaaaacac acctgaaagt gttatctcga gagaatgctg tggatgcagg aggttgctgg
5881  gcagcacaag cagcttccgg ggatctaact gctctgccag caccacacgg aaacagggcc
5941  tctggcaaca ccacaaggac acaggacctc tggcaaccca cccggaacca cagacgccct
6001  ggtaccaggt agccctggcc accagcacct caaggaaaca gggcctctgg caacccatct
6061  ggaatcacag acaccctggt atcaggtagc cctggccacc agcacctcaa ggaaacaggg
6121  cctctggcaa cccatctgga accacagacg ccctggtacc aggtagccct ggccaccagc
6181  acctcgagga aacagggcct ctggcaaccc atctggaacc acagacgccc tggtaccagg
6241  tggccctggc caccagcacc tcgaggaaac agggcctctg gcaacccatc tggaaccaca
6301  gacgccctgg taccaggtgg ccctggccac cagcacctcg aggaaacagg gcctctggca
6361  acccatctgg aaccacagac gccctggtac caggtagccc tggccaccac agcaccacag
6421  ggtgcaggac acaagcaggc ctcagccggt cccctctgtg cccaacagca actgacaggc
6481  ccaccgtgat gggaaaacat cccaaagctg catacggtag ctccggcaca tcactcctgc
6541  ccagtagctc agagccagcg acaaggcaag ataaagctgg ccacagatga gcagccagga
6601  gcacatccca gggaaatgca cggaaacctg ccctggatta ccggaagctg caacctccac
6661  cccacgtggg aggaatactc agaaagctct ccttcaaatg atctcaaaga atgagtccac
6721  acagcggaac accaaggcct aatgcccaag ttgtcttttt tttttttctt ttcttttttt
6781  tttttttttt ttgagacgga gtctctgtca cccaggctgg agtgcagtgg cacaatcttg
6841  gcttactgca agctctgcct cccaggttca cgccattctc cggcctcagc ctcctgagta
6901  gctgggacta caggtgcctg ccaccgcgcc cggctaattt ttttgtgtgt ttttagtaga
6961  gatggggttt cactgtggtc tccatctcct gaccttgtga tccaccccac ctcggtctcc
7021  caaagtgctg ggattacagg cgtgagccac cgcgcctggc cccaagttgt ctttcttaag
7081  ataacactcc gggccaggca cagtggctca cgcctgtaat cccagcactt taggaggccg
7141  aggtaggcgg atcacgaggt gaagagatcg agaccatcct ggccaacgtg gtgaaacccc
7201  gtctctatta aaaatgtaaa aaaaaattag ctgggcatgg tggtgggcgc ctgtagtccc
7261  agctactcag gaggctaagg caggagaatc gcttgaaccc gggaggcaga ggttgcagtg
7321  agccgagatc acgccaatgc actccagcct gggcgacgga gtgagacgcc gtctcaaaaa
7381  aaaaaaaaaa aaaaaaaaag ataacactat ttctttcatg gctttcatgg atgaccctaa
7441  ggatctgcct ccacttagcc tcagataaga aaagagctaa tatgtcacca aggtggctca
7501  ataatcccct ccttggtcag cagtctgagc cctgtgtggc ggtcactcaa ctgttatata
7561  atctgcccga ctgtttctgt ggctctgagt gagcgtggct tatactatct gtcctcacca
7621  gaacagggct ggggtgaacg gccattcggt acataccttc aactggaaca gggtatctgc
7681  aaagaaagag ggaattaatg gtttgaggat tgggaatggg acgttacact tctggcaggc
7741  aggactcact aggttccttc tagacaccag gagctagaac acacacacag accacacctg
7801  cctggggcct tcggggagcc ccccccaaca ggggaggcac gagacagatt cgtgtgccag
7861  ccctggctcc ttgctagcca cagggcccag caaatgcaga ccctccctcc ctgtttcctt
7921  gttgggaaca tgagggtggt accagccaat ctcaaagggt tagtgtgagg acagaagagg
7981  tcatggacgc agcatctttt ggccatggtt agaatccaaa agatggtggt ttataattaa
8041  tgcaactttg caaaWgtccc ttgggattct ttcccaattt aaaagttcac ctgtaatccc
8101  agcactctgg gggtgccgag gccagtggat cacttaaagc cagggtttga ggccagcctg
8161  ggccaattta aaagtKcagt acttgacagt ttacttttta cagactcttt ctcctcaaag
8221  gtaaatggat aaaaatagca aggtggtaac tcttagacat caaagagctg atttccagcg
8281  gtacagtcRc tcacgcctgt aatcacagca ctctgggagg ctgaggcggg cagatcactt
8341  gaggtcagga gttccagacc agcctaggga atatagtcag acctcatctc tattagaaaa
8401  atatatattt ttttgccggg tgcggtggct cacgcctgta atcccagcac tttgggaggc
8461  cgaggccggc ggaacatgag gtcaggagat cgagaccatc ctggctaaca cggtaaaagc
8521  ccgtctctac caaaaaatac aaaaaattag ccaggcgtgg tggcgggcgc ctgtagtccc
8581  agctactcag gaggctgagg caggagaatg gcgtgaaccc gggaggcaga gcttgcagtg
8641  agccgagatt gcgccactgc actccagcct gggcaacagt gcaagactcc gtctcaaaaa
8701  aaaaaagaaa aaatattttt tttaaaaagt aggattgatc tcaattcatt caactgctaa
8761  atttggagag cgaccctgac cccagattcc tgaaagggct ttaccacact agccacaacg
8821  aggaaatgga gcctgtaaaa gaatgaggtt actgagtgtt cacaaatgca caccaaggct
8881  ccaagatgag atctcccggg gttccagaaa gctctgggca tcgttcaatc tatcgcctgt
8941  cagtgcaggc gtggtcaagg ccaagttcaa cctgtcatct atcagttcag gtgtggtcac
9001  ggccaaggtt atctgtgact ggaaaacagc cagcctgacc cagatggcac agtgcaggcc
9061  aggcgggccg tcccacccaa ctcactgtgg gatgctggcc aaaccgccct cctcatctca
9121  gctttccctc acctcagctt tccctcacct cagctttccc tcacctcagc tttccctcac
9181  ctcagctctc ctcacctcag ctttcctcac ctcagctttc cctcacctca gctttcctca
9241  cctcagcttt ctcttccagc cgtgtgtggc agcacaaaaa cccagctaag gcaaaatctg
9301  actctgagga aatctgacat gggcttgaga gaagtcccct caaaagagtt gagtgagctg
9361  tggagtgaaa agccacaatt tttctttttt ttttttgaga cggagtctca ctctatcacc
9421  caggctagag tgcaacggca ccatcttggc.tcactgcaac ctctgcctcc caggtttaag
9481  cgattctcct gtctcagcct cccaagtagt tagaattaca cgtgcacgcc accaggccca
9541  gctaattttt gtatttttag aagagacggg gtttcaccat gttggccagg ctggtctcaa
9601  actcctgacc tcaggtgatc aaccaacctc ggcctcccaa agtgttgggg ttacaggcgt
9661  gagccaccac atccggcctc ccaaagtgct ggaattacag ccgtgagcca ccgcgcccgg
9721  cctcccagag tgctRgggtt acaggcctga gccaccacac ccggcctggc cagcatattt
9781  tttgtggcgg gaggtagatg ttatctttca tcttctctca gggcagaaaa tctctacaca
9841  tttccttcat gatgatgaca cggtggtact atagcttttc acacttctaa ctaaaagaat
9901  tttttttgag acggagtctc gctctgtcgc ccaggctgga gtgaagtggc gcgatctcgg
9961  ctcactgcaa gctccgcctc ccgggttcac gccattctcc tgcctcagcc tcccgagtag
10021 ctgggactac aggcacccgc caccacgcct ggctaatatt tttgtatttc tagtagagat
10081 ggggtttcac tgtgttagcc aggatggtct cgatctcctg accttgcgat ccgccggcct
10141 cggcctccca aagtgctggg attacaggcg tgagccaccg cgcccagccc ttcaaaaagt
10201 atttttaaaa gcctgcccat cacaccagcc caacgatgtt tcagcaaaca taggacttca
10261 ttttgccaga ttcttcctgt tctttggtat ccctgagcac acagccggct agccccagat
10321 gtagaaggta agaattaggg cgacccattg agcacagaaa cgcttgtgct ggctcctgct
10381 caaacctctg cttccccaca tggagaatgg acgcaaagag ctgctgtgac cagggcctgg
10441 cactcaggga gcgctttctg tctgagtcct tctgatttgc agtgatgctg tttggggcag
10501 ggggtgcaac tgtcactttt tctggtgccc tctgacccga cattccaagt cccgaaaggc
10561 cgaacaggca tcgcacagtc ccccctaccg agctggcggg aaagggcgcc tgacgctgag
10621 gagtgccagg ggcgggggaa agggtcctgg gtcggtggtc gggggtccag gccctgggca
10681 aggggtcctg ggtcgggagt ctaggtcccg ggtccatggt tgggggtcag aggtcgaggc
10741 cccggggaag gcataccggg ttgagatttg gggatggagg ccccggggaa ggggtcccga
10801 atcgggggtc ggggatcgag gcctgggggg aggggtcccg ggtcgagggt cgaggcccgg
10861 ggtaaaggat ctcgggttgg gggtcggggg cctgggaagg gtcccggtcg gtggtcgggg
10921 gtcgaggccc gggagaaggg gtcccgggtc ggtggtagag gccctgggga aggggttccg
10981 ggtcggggat cgagggtcga ggcccgggaa aaggggtccc gggttggtgg tctaggccct
11041 ggggaagggg ttccgggtcg ggtatcgggg gacgaggctc gggaaaaggg gtcccaggtc
11101 ggtggtcgag gccctgggga tggggtccgg gtcggggatc gggggacgac gaccgggaaa
11161 aggggtccca ggtcggtggt cgaggccctg gggatggggt cccgggggat cgacggtcga
11221 ggcccgagct ctcctgagtc ctgcccgcgg ccccaggtgg gcggagccca cgccagtggg
11281 agaagcggcc ccgccccgcg cgcgagtccc cggaggacgg ccgcgacctc ttaccgtcca
11341 tggccacaat gacaggagca gcactcggag agggagaagg gacgccaact ccgggcggtg
11401 tcaggtcccg gcggcgatcg aaccgaccaa gctgcacccg gcggggactt ccggggtcgc
11461 cgccccactt ccggtcgcac gggatgctct cgcgagagga tggtggccgg tcccgccaga
11521 ggggcggggc gcggctgcgc ggcgcgcggt cgccatggtg acgcacgccg ctggcgcgag
11581 gaccttttgt gagtcgctcc cggctccgcg gccgcggagg tgtggggacc cgggcttgcg
11641 tcggaggggg cggtgggctc acccatgggc ctttccaaaa gcaaagagaa acccaggaaa
11701 ggtaaaggag gcgcaggcgc tgggctcccc gcgtctccgc ccctgggcgc gggcccaggg
11761 cggggctggg ctgggcgggg cggtgtgagc gcaggcgcca ggctcggccc ggtgcgaacc
11821 gttcctgccg ccgagtccgc cacggacggc gcgtttcccg cctgaggcgg ttacggaaac
11881 gcggagactc gagacttgaa gccagcttat tctggatcca cgcaggcgac tgaagacgat
11941 gggacccact gccctgcatt cggtaagtcc cgggtctaac ggatgatcca tatatttcag
12001 gtgaggagca aaagaaggga tccacctatt cagttccaaa atctaaggag aagttgatgg
12061 agaagcattc ccaggaagcc aggcaggcag acagggagtc ggagaagcct gtggacagcc
12121 tccacccggg ggccgggaca gccaagcacc cgccgccggc agcttcgctg gaaggtagga
12181 gacggcggga gggagcgaag cgaggtcagt ggcttggagg atctggggct ggggtgagga
12241 gcctactgta agaccctacc ggatggacac tagtagcagg cacgcgccgt aaagatgaaa
12301 ctggtttgtt ttgggaactt tatgtaggag gtaaatatcc agaaatctta gttgaaaaca
12361 taagtttaat gaaaatgtag gtcagttccc gagtgataag tgcgtaccag gtggtcgagg
12421 ggctggggca gtgtgcgtgt gtctcacctg aggttctcct cgagggctgg gtatcttggt
12481 gccactgaga atccctgagc ctccgcacac tggaacagag cattgggagg ccgtcccagg
12541 ctggactgta gctctccgag ggctgtgggg ataagtacat tgcggagggt gaccgaggag
12601 tagaacctgg gtgcgacaaa ggtgtctttt ataacagcct agtgtggcca gacctttggg
12661 tgtgtgtggg gaagatgagg ccccaaaagt aggaagaagc tagaatacaa agttttccat
12721 cagttttacc acgtggagct ggaagcgtta aatattttaa acaacggagg tgctgcctgg
12781 ggcggtagtt cacacctgtc ctcccagtta tttggccgag gcaggaggat cttttgagcc
12841 caggagttca agaccagctt gggcaacata gtgagaccct gtctctacaa aaaataaata
12901 tttaaaaata aaaaacaagg gcggcatgat gaggtctgtg cctaccaaca ggggaagcca
12961 gttcgcaggg gaggtggccc ggtcagagac ccattgctgt ggcccagtgg gagccagcaa
13021 ggccttgcag taggaattgc agaagggtca ggcagggaga acccgcagag cctgccgtcc
13081 gaggagattg ggggcctgtg ccaggaggag gtgttttaag tttcatcaca agaatgaacc
13141 actcggctgg gcgcagtggc tcacgcctgt aatcccagca ctttgggagg ccgaggcgtg
13201 tggatcactt aaggtcagga gttcaagacc agcctggcca acgtggtgaa accctgtctc
13261 tactaaaaat acaaaaatta gctgggcgtg gtggcatgtg cctgtaatcc cagctactca
13321 ggaggctgag gcaggagaat tgctcgaacc ttgaaccggg acccgggagg cagaagtagY
13381 ggtgagcgag atcgcaccac tgcactccag cctgggctac agagtgagac tctgtctcag
13441 aaaaaaaaaa aaataataag gagagaacca ctcgggtcag acaagaaaga atgtcagggg
13501 gatgactggc ctgctaggca gaggagctgg gcctggactg cttcacactg acacgcttgt
13561 aggatcaagg gctgaaagta ggaggctctg ggccttggac ttggaagaaa gacttggatt
13621 tgaattccca actttggaac ctcccactgg agggtggaac ccctcacagg agggcgcaac
13681 cccccaccgg aggatggaac cctgcaggaa tagcatcacc cttgggtggc agtttggaaa
13741 atgctacctg tctgtcacgg tgcttttagc tgaaagttac agaaaagctc actaaacgca
13801 gctttaacac agggatttaa tgtctcacga atgaagggtc agaggtggag cttccaggtt
13861 ggcttgttag cacaacagtg acatcaaaga ctttgcgtgt ctcttcttga ccactctcag
13921 tgtccacagc ccccgatgag tgtacagccc cccacacgca ggcaggactg catctactgc
13981 aaaggcattg ctccttgctt catattagca aggaaacctt tcccaggaag gcttcgcctg
14041 cccagcctct gcaggactca ttcaatggtg caaattcacc aggggctgga gggagctgtg
14101 aagcatggga gtgggcagga cctctgccag taacggaagt gggggaagga ggaccgcctg
14161 ttggaagggc cccagcagtg tctgtcacac cagagggtgg gggaggaagg tggacatgaa
14221 gggaaaacag cagagcaaga gtgagaacag agtttcagca gataaaatga agtgtgcacg
14281 ctctccatgc agtgacgggc tgagcgacag tgaggagcag gctgctgact cccttgccac
14341 accgtgaagg agtcccaaag gtgggacact gagtgagaca agccagagga aagaccactc
14401 atgttgcagt tccctttcca tggaatgtcc agaaaaggca catttacaga gagaagcaga
14461 tgagtggttg ctgggcagaa atgggagccg gccacagctg agcacaagag gactttggag
14521 ggtgatggaa atggttttcg acctgaatct gaacatggga agcactgcag tttagtagtc
14581 ctggtcccta agcccttcca gcccaggagc cagacctgtg agcaaacaag cctttagtga
14641 ttccaggctc tggctggaac cttgagtctt ctcagcttgg ggcatgcacc tcagggggag
14701 ccagcatcag tgtccagccc caagagcttc cctgtacgtc tcagtgagtc ttcacatgcc
14761 tccaactgcc tggacaacca cacgtgatac ctgtcctgcc aaacgtgtcc tgaacccata
14821 aaatccagag aaaagaaaat cgttttaaac tgctgaggtt tggggtaagt tactatgaag
14881 cagtagtgag aagaacagaa gggccatgat ggggagaaag tttggccata agttaatcaY
14941 tgtggcagct gttaggatat tgatgtggct tggctgtgtc ctcacccaaa tctcattttg
15001 aattcccaca tgtgggagga actgggtRgg aggtgattga attatggggg caggtctttc
15061 ctgtgctgtt ttcgtgatag tgaatgagtg tcacgagatc cgatggtttt aaaaacggga
15121 gtttcctgca taagctctct ctctgcctgc tgccatccat gtaagatgtg actcgctcct
15181 ccctaccttc cgccgtgatt gtgaggcgtc cccagccatg tggaactgta agtccattaa
15241 accttcttcc tgtgtaaatt attcagtctc tggtatgtct ttattagcag catgaaaacg
15301 gactaataca gatagatgta ttatactgtt acccctacta cttctgtata tgcttaaatt
15361 tttgcattac aaaattcaca aacatacaaa cattatagag aactaacatc acagatttac
15421 agtcacctta ttccacaatg ttggaaattc taccacaaat aaagaacttg aaaaaaaagg
15481 aggggatgtt agaaggaaat ctgagcgacc tagacctggg ctcagtcacg cctgagacag
15541 tcagatgggg tatctgagga tgagtcagtg ttaattttct cagacctggg ctccgtcact
15601 cctgagacag tcagattggg tatttgagga tgagtccgtg ttaattttct tagatgtggg
15661 aatgctatta tagttacgct aaaacacaat ccctatctaa taaatacact gcaacattta
15721 tgggtaaaat catatgtctg aaattcctta aagatactca gaatgccagg catggtggct
15781 catgctgtca tcccagcact ttgggaggcc gagacgggtg gatcacttga ggtcaggagt
15841 tcgagaccag catggccaac atggtgaaac cctgtctcta caaaaaatac aaaaaaatta
15901 gctgggtgtg gtggtgcaca cctgtaattc caactacttt ggaggctgaa gcaagagaat
15961 agctggaacc caggaagcag aggttgcagt gagccacgat catcccactg cactccagcc
16021 tgggcaatgg agtgagactc catctcaaaa aaaaaaaaga tactcaggaa aaaaacgaag
16081 aaagaacaag ataacaaaat actgattgaa gctgagtgct ctataggtgc aggtgctcat
16141 tcactattct attttcttgt gtgtttgaac actttttttt ttttttgaaa tggagtttcc
16201 ttcttgttgc ccaggctgga gtgcaatggc atgatctcgg gtctcaactc actgtagcct
16261 ccgcctccca agttcaagtg attctcctgc ctcagcctcc caagtagctg ggattacagg
16321 cgcccgccat gacgcccagc taattttttt tgtattttta gtagagatgR ggtttcgcca
16381 cgttggctag gctggcctca aactcctggc ttcagctgat ccacccgcct cggcctccca
16441 aagtgctgag atcacaggcg tgagccaccg cacctggcct cccagagcgc tgggatcaca
16501 ggcgtgagcc accacgccca gcctgtttga acacttttgt gacgttttgt tgtttgtttg
16561 ttttgagatg gagtcttgct ctgttgccca ggctggagtg cagtggcaca atcttggctc
16621 attgtgactt ccgcctcccg ggttcaagca attcttctgc ctcagcctcc cgagtagctg
16681 Rgactacagg tgtgcgccac catgcctggg taatttttgt atttttagta gagacggggt
16741 ttcaccatgt tggtcaggct ggtctcaaac tcctgacttt gtgaaccacc cgcctcagcc
16801 tcccaaagtg ccagtgttac aggtgtgagc caccacgccc ggcctgtaac attttcatga
16861 aggtagagta tacttaattg caagaaaatt ttgaaaaaga agagaaatgg aacacttcKa
16921 ttggctatta aaaaatacca tgctgagtga aaaaagccaa tcccagaagg tcacatgctg
16981 tatgattcca tttctttttt tttttttttt aggctggagt gcaaatggca cgatcttggc
17041 tcactgcaac cttggtctcc cgggttcaag caattctacc tcggcctccg gagtagctgg
17101 gactacaggc atgcgccacc atgcccagct aatctttgta tttttagtag cgatggggtt
17161 tctccatgtt ggtcaggctg gtctcaaact cccgacctca ggtgatccgc ttgcctcaaa
17221 ctcccgatct caggtgatcc gcttgcctcg gcctcctgaa atgctaggat tacaggcgtg
17281 agccaccata cccggccgtg attccatttc tgtaacattc tctgaatgac aaaattatag
17341 acagggagga cagattgttg attgctaggg ccttggcgtt ggggtaggga gtgagggggt
17401 ctgtgaaggg cagggctttg gggttggggt agggagtggg tgtgtctgaa gggcagcagg
17461 aggaagatgg gattgttggt tttggtggtg attgattaaa tggcgtagct gtacatacac
17521 tcatagtacc ggagtccatt tcctcgtgtc gataatggta ctatagttat ataaaacgtt
17581 cgctttggga gccaagcaca gtggctcacg cctgtaattt cagaactttg ggaagcctag
17641 gcaggcagat cacttgagYc cagaagttca agaccagcct gggcaacatg gtgaaacctg
17701 atttttacaa aaaagacaag aattagctgg gtgtagtgga gtgtgcctgt agccccaact
17761 aatcaggggc ctgagatagg aggatccctt gaccccatga ggttggggct gcagtgagcc
17821 aagatcgtgc cactgccctc cagccccggc gacagagtaa gaccctattt atgcttccta
17881 gcaaggaaag acagtacaca tattgaagaa tttgactgcg ttaaaatgtt aaacctctcc
17941 ccaaactctt ataaacaatt gtagaacaaa tgataagctc aaaaaaatat ttacatctat
18001 gagaggccaa agaatatcag ttgactctgg atcaggggct cggacacgtt gctgtggagg
18061 cacacatctt cctggaaggc ggtttggtaa caaggtggca ggactcaaga cagcccacac
18121 gatccctgcc cctgggaaac agccatgtgt aaccctcccc tcgagtgtgg gYggaatgag
18181 gaagagggag gtgtgtctct cctgcgatta gctcactcat ccattgagtt tgacgtcatc
18241 aaaatgcgag atgatcctgg atgggcccga cctgatcagg gaagccagac agtaaaagtg
18301 tcagaggctc tttagggccc gacctgatca gggaagccag acagtaaaag tgtcagaggc
18361 tctttagggc ccgacctgat cagggaagcc agacagtaaa agtgtcagag gctctttagg
18421 gcccgacctg atcagggaag ccagacagta aaagtgtcag aggcttttta gggcagcgag
18481 aaaacgggaa cttcattcct tgaaccggga ataaattctg cctccaaccR gaatgggctt
18541 agaagagggt cctccagctc ctcatgagaa tgcagtgcag ccggcccctg gaattcagcc
18601 tgcgtcccag ccacgctgca cctgcacccc tgacgacgaa tgcagtaaga tgataagtgg
18661 atgtgctggt ttcagccctg aagttggtgg tgatttgttg tgcagcaata gaagtacaca
18721 caatatgtac caagaacctt gagaagagtc acatttattc tttctgtttt gtttctgaga
18781 tggtctcacc caggctggag tgcagtggca ccatcttggc tcattgcact cttgacgttc
18841 tgggctcaaa cgattctccc acctcagctc cctgagtagc tggggccaca gtgcacgcca
18901 ccacccccag ctattttttg tagtttttgt agagatgcgg ttttgtcatg ttgcccaggc
18961 tggtctcgaa ctccagaggc caagcaatct gcctgcttca gcctcccaag gtgctgggat
19021 tacaggcgtg agccaccgca cctggcccaa gattaatatt tctttttttt tttgagatgg
19081 agtcttgctc tgtcgccacc caggctggac tgcaatggtg catctctgct cactgcaagc
19141 tccgcctccc gggttcatgc cattctcctg tctcagcctc ccgcatagct gggactacag
19201 gtgcctgcca ccacgcctgg ctaatttttt gtattttttt tttttttaag tagagatggg
19261 gtttcactat gttaaccaga atggtcttaa tttcctgacc tcgtgatccg cccgcatcgg
19321 cctcccaagg tgctgggatt acaggcgtga gccactgcgt ctggcctaat atttctaaat
19381 gaagaaacta tactYtgagg aagatgaaat aagtcttgtt ttagactaga aaatttcaat
19441 agtgtaaata cgttaacttc tgtaaaatca gtcaacacca agtcaaaaca caaaagatct
19501 tttgggaata tgagcagatt attcaaaggt tcatctaaag aataaaaatg aggccaagtg
19561 tagtgattca cgcctgtaat ccYggcactt tggaggccga ggcaggtgga tcacttgagg
19621 tcaggagttc aagaccagcc tggccaacat gatgaaagcc catctctact aaaaatacaa
19681 aaattagcta ggcgtggtga tgggtgcctg tagtgccagc tacttgggga ggctggggca
19741 ggagaatcac ttgaacctgg gaggtagagg ttgtagtgag ccaaaattgt gccactgcac
19801 tccagcctgg gcgacaagag tgagaatcca tctcaaaata aataaatgaa taaaaatgaa
19861 agcagtagga aacatctgga aaaccagagg catgaggggg tcgggccctc tgatactcaa
19921 gtaggttaga gtaaaaaaaa gccagatatg gtgatgtggg aatatatggt cccataggtg
19981 ggatctgtgg ttccagctac tcagtgaggt ccgaggatca cttgggcctg ggaggttagg
20041 actgtagttt gctatgatca catccacgaa tagccactgc gctccttcct gggctacaga
20101 gtgagaccct tctctaaaaa tggaagaaaa tggccggcac agtggttcat ggctgctgta
20161 atcccagcgc tttgggaggg tgaagtgggagaataacttg agcctgagag ttcgagacca
20221 gcctgggcaa catggcaaaa ccgtgtctct acaaaaaatt tcaaaattag gtgggtgtgg
20281 tggtgtgtag ggtccagccc cacagggtcg gtgggttttc tccccatgtg cggagatgag
20341 agagcgtaga aataaagaca caaggcaaag agataaaaga cagctgggcc cgggggacca
20401 ctaccaccaa gccgtggaga ccggtagtgg ccccaaatgc caggctgcac tgatatttat
20461 tggatacaag acaaaggggc agggttagga gtgtgagcca tctccaatga taggtgaggt
20521 catgtgggtc atgtgtccac tggacagggg gcccttccct gcctggcagc caaggcagag
20581 agagaggaga cagagagaca gcttacgccg ttatttcagc atatcagaga cttttagtac
20641 tttcactaat ttgctactgc tatctaaaag gcagagccag gtgtacagga tggaacatga
20701 aggtggacta ggagcgtgac cactgaagca cagcatcaca gggagacgat taggcctctg
20761 gataactgcg ggcaagcctg actgatgtca ggccctccac aagaggtgga ggagcagagt
20821 tttctctaaa ctcccctggg gaaagggaga ctccctttcc tggtctgcta agtagtgggt
20881 gtttttcctt gacactgacg ctactgctag accatggtct gcttggcaac gggcgtccta
20941 ccagacgctg gcgttaccRc tagaccaagg agccctctgg tggccctgtc tgggcataac
21001 aaaaggctca cactcttgtc ttctggtcac ttctcaccat gtccccccag ctcctgtctc
21061 tgtatgacct ggtttttcct aggttatgat tgtagagcga ggattattat aatattggaa
21121 taaagagtaa ttgctacaaa ttaattaatg atattcatat ataatcatgt ctgtgatcta
21181 gatctagtat aactattctt attttatata ttttattaca ctggaacagc tcgtgccctc
21241 ggtctcttgc ctcggcacct gggtgacttg Ycgcccacag tggtgcgtgc tggtggtccc
21301 agctacttgg aaggctgaag tgggaggatc atttgagccc aggaagttga ggcttcagtg
21361 agccatgatc atgccacagc atttcagcct gggccacaga ccttcaagat cctgtctcaa
21421 aaagaaaaag ggRtatcKct cagtgcttag tgcagctgtg ggtcattcgg cagctgacac
21481 agatgaggct atgtaacgca gcactgcagg cagaggggga ggccaaggcc tgaatacccc
21541 gtctgactag ccttaggcag gcgacttggc ctctctgcct cccccatctg gttagccttg
21601 ggcagtcgag ttggcctctg tgtctcccct gtttgactag ccttgggcag atggcttggc
21661 ttgtctgtac ctcagttttg tctgaaatat gggYtgtcag agacetatag cagaagctgc
21721 tgtgtgtcat tattcactgt tctagggctc agaacaggca cgcgataaaa gccagcaccg
21781 ttggccgggc gcattggctc acgcctgtaa tcccagcact ttgggaggcc aaggcaggta
21841 gatcacctga ggtcgggagt tcaagaccag cctggccaac atggagaaac cctgtctcta
21901 ctaataatac aaaaattccc caggtgtggt ggcaggagcc tgtagtccca gttgctcagg
21961 aggctgaggc aggagaatca cttgaactca ggaggtggag gttgcagtga gccgagatca
22021 caccactgca ctccagcctg ggtgacagag cgagactccg tctcaaaaac taagaagaag
22081 attaataata aaccagcact gccattgcca gcagtccatc ctacctcgca tccaggttcg
22141 tgagctacca agtgtcccca caaagctgta aaacaRcatg accactgtag ttacgtttct
22201 gtaaaaaggt gactgagtct tctaaccctg accacacata tgtgtgcaga gagagccagc
22261 tccatcctgc tctcccagaa gcctgaacag ctgtgcccta gctcgtagca gtggcactcc
22321 aggaaggggg cgggcggctg tgcccgagct cgtagcagtg gcactccagg aagggggcgg
22381 gcggctgtgt ctgagctcgt agcagtggca ctccacgaag ggggtgggcg gctgtgcccg
22441 agcttgtagc agtggcactc caggaagggg cggccggcca gccaggagag cagccggtga
22501 aggagcactt ttgctttgta cgtggcaacg ctcggcaggc tcagcagttt cacaggtctc
22561 aggcgttcct tgtaacctta acaggtttaa gaaaatgtga gcaacatcag acatgtccat
22621 ttctagaaca ttctaatgga tgaagttctg tacagagggc tttagcagaa ttagagacct
22681 ttggagtgga aatgatgtct ctgaaccttg agctctgagg cggttcctgc ctggacgtgt
22741 gccctccctc cttcctttgc tggtcgccct gacaccatcc tgccacggat agtggaagtg
22801 tttctcctgt tttcttccct gaaaaagggt gtccagcatc agcaaccttc atggctgagt
22861 tgcacatccc ttaagccctg taatgttcat ggacagtttt gatcactttt ggactcaccc
22921 attttttctg ctaaccatac atcttaattc ctttactctg accaatggca ggaggtgtgt
22981 gcatcgtgga aggagctttc cacacatcta ctaaatgcct ggatgttttt tcctctagag
23041 aaacctgatg taaagcaaaa gtccagcagg aagaaagtgg tcgttccaca gatcatcatc
23101 acgcgagcgt cgaatgagac gctagtcagt tgcagttcca gcgggagtga ccagcagaga
23161 accattcggg agccggagga ctggggcccc taccggcggc acaggaaccc cagtacagca
23221 gacgcctata attcacatct caaagaataa acaagcacct ttgcatggca ctcgctactc
23281 cctgcgatag gcgtctcggg aacagccgcc tcaccctgtg agaagccgag gccccttctc
23341 cagtgctctc ggggaggttg caccaggccc accccaccct gtgagaaact gcagccccct
23401 tctccagtgc tttcggggag ggtgcaccag gcccgcccca ccttgtgaga agccgtggcc
23461 cccttctcca gtgctctcag ggagggtgca ccaggcctgc ccccgccgtg agaaactgca
23521 gYccccttct ccagtgctct cggggagggt gcaccaggcc caccccaccc tgtgagaacc
23581 tgcagccccc ttctccaatg ctctcgggga gggtacacca gggttgcccc accctgtgag
23641 aagccaccgc ccccttctcc agtgctctcg gggagggtgc accagggctg ccccacgctg
23701 taagaagccg ccgccccctt ctccagtgct ctccagcccg ccccaccctg tgagaagcca
23761 tggccccttc tccagtgctt ttggggaggg tgcaccaggg ccaccccacc ctgtgagaag
23821 ccgtggcccc cttctccagt gctttcgggg agggtacacc aggcccgccc caccctgtga
23881 gaagccgtgg cccccttctc ccgtgctctc agggagggtg caccaggcct gcccccgcct
23941 tgagaaactg cagccccctt ctccagtgct ctgggggagg gtgcaccagg cctgcccacc
24001 ctgtgagaaa ctgcaccccc ttctccagtg ctctcgggga gggtgcacca ggcccgcccc
24061 accctgtgag aagccgcagc ccgttctcca ttgccatttg gtcctgcctt ccccagagct
24121 gctagcagct cggtcgaggc aagagtgact ggctcagaga gcgagctttg tggtattgat
24181 aaatgaataa attagtatgt tcatgttgga agtggctggc tctgcagagt gatggacagc
24241 aggtggcatc ttacattgtg atttgtggtg cacagttaaa acacttccct tcgtttcaga
24301 aggagacaat gtgaatactt ggaaattata gtgaataaga tgcctcccaa acttgaggaa
24361 aaggtcagat tctaagagct aaacgttaag atgtaatgtt ccagaacaaa gaggcccaga
24421 gtcactgaac ggggccccag ggctcctagc ttgagtgtaa tctgagtcag cttatgaaaa
24481 ggccccaaag aagaaagtgg aatgtgtgct gggcacatgg gacagccatg gcactgagac
24541 tttggaagtg gccttgccag cgctgtcctg tctttctggc ccacagatga gggctcctga
24601 ttgtggaagg ccacggaagg gacctgaaca cgatggcacg agacaagtta tctcctgtga
24661 ctgctcctct ccagcaaccc tcagctcagg ctagactttc cccctgtgtt gagaatgccc
24721 tgccctgtgt ggaagcctga tgcatttagt gacagtgtgt tagctttgtt agtttctagt
24781 ctggccagca ggctttccat gtgatctgcc attggcttgc ttcagtggcc agtggagcca
24841 ggggtgtcca ccagagtctt ggacacagac ttctgaggtg gcagcgggag ggagcctgct
24901 ccctgccaca cacgtacaat ttctaatcca tacaggccta tgtagtatat acacacatac
24961 gcagagcctt aggaattgtg aaaggccaat caaaacttgg ggccctaatt tcactctgcc
25021 aaaagaaaaa aaaaaaaagc tgaaagatga gtcacccaag aaactgcttc ctttttgttc
25081 ctaagcagag agctaccaat aaaaagttaa agtttctcca taggtagcta ctctgttcac
25141 cttctgtgaa gtgccaaatt ttttttttat tattatactt taagttttag ggtacatgtg
25201 cacaacgtgc aggtttgtta catatgcata catacgccat gttggtgtgc tgcacccatt
25261 aactcgtcat ttacattagg tatttctcct aatgctttcc ctcccccctc ccccctaccc
25321 cacgacaggc cccagtgtgt gattttcccc ttcctgtgtc caagtgttct cattgttcag
25381 ttcccaccta tgagtgagaa catgcggtgt ttggtttatt ttacttgcga tagtttgctg
25441 agaatgatgg tttccagctt cacccatgtc cctgcaaagg acatgaactc atcctttttt
25501 atggctgcat agtattccat ggtgtatatg tgccacattt gcttaatcca gtctatcact
25561 gatgggcatt tgggttggtt ctaagtcttt gctattgtga atagtgccgc attaaacata
25621 ggtgtgcatg tgtctttata gcagcatgat ttataatcct ttgggtatat acccagtaat
25681 gggatggctg agtcaaatgg tatttctagt tctagatccc tgaggaatcg ccacactgtc
25741 ttccacagtg gttgaactag tttacagtcc caccaacagt gtaaaagtgt tcctatttct
25801 ccccatcctc tccagcacct gtttcctgac tttttaatga tcgccattct aactggtgtg
25861 agatggtatc tcattgtggt tttgatttgc atttctctga tggccagtga tgatgagcat
25921 tttttcatgt gtctgtaggc tgcataaatg tcttcctttg agaagtgtct gttcatatcc
25981 ttcacccact ccatcaaaaa gtgggtgaag tgccaattta ctgagcacga gacaaataca
26041 tcattgactt cttttgtctt gtggattcaa ggatgtgtcc acgcccgccc tccttcccct
26101 ccagctcctc cccttgaaat actgaagccc tcaacatcat ctttggagga aggtacagag
26161 ttggctctca cgcgcacatc cttaaccttg gcctaataaa cctctaaggt ggctgagacc
26221 tgtctcagat acttgttggc ttacaaattg accaccatgc agggactcag agtggaggtg
26281 gccctgccct ttggcaggtt tcctcctggt gcttaggacc agtttgggcc ttctttattg
26341 ctcaggacag taggacaatt tgctgagatc cgggagccct accaccctcc agagaatctc
26401 tgatctcccg aaacttggtt gaggtcgaaa gtttattttg cgcacaatgc cttttccttt
26461 tccggtgttt tacttgcttc caacaaagaa ggcgagtttt cctgcttccg tgatgatggg
26521 gagcaggaga cttccctgga gtttcagctc ggaaacaact cgagtttttc ctgattccac
26581 gatgggggag agcagtctaa agcctgggcc ccattcctag gtaagtggct gaattggggt
26641 tctgtcttgg aagttctcct taatgactaa agctaacatt aacgactggc tggtcttaac
26701 ttcttactat tagcatgctc agtaagtgta taaattgtgg gattgtttgt tttgcttaac
26761 tgctttttgt ttgtttctgt gtttgctatt tttgctgttt cagtcttttt cccgttggat
26821 ttgacgaatt ctgttagact tggtcaaatc tgaagcaaac ttccaagttg tgggaaacaa
26881 gcctctgaat tagctgaatt cccacagctg ggaaaaagga aaaaaagcca gaaaaaggga
26941 aaaaagattt tgaccacgtg atgggcttta tttgcataac gaggccacgt ttttccagcc
27001 aagccacact cgaagagtaa gtgccgtcac ctcacgctgc agttcggtag gtagagtccg
27061 ccatttttcc accaggacag cccgggtttg gttcctacat cctttctggt ttgaaatttg
27121 tgttactttt gaaatatcag cagtttgtcc cggctgaaat aaggtagtga gatttaaaga
27181 tttaaaagga ttttcttttt ttttgagacg gagtctcgct ctgtcgccca ggctggagtg
27241 cagtggcacg atcccagctc actgcaacct ctgccgccca ggttcagcca ttctcctgcc
27301 tcagcctccc aagtagctgg gattacaggc acttgccacc gcacctggct aatttttgca
27361 tttttagtag agacggggtt tcaccacctt gaccaggctg gtcatgaact cctgatcttg
27421 tgatccaccc tccttggcct cccaaactgc tgggattaca ggcgtgagcc actacgccca
27481 gccaagagga tttttaaaag ggcttaatgg tcaaaagtaa acttaactaa aagctaatat
27541 cggatatatt ccaacatagt agcttaatta agtccgtatg ccacatacac atatacagac
27601 ccctgtgtag aaaagaaggc accagactcS tttttgggga gaaacttctg tttttcttat
27661 ggaactccaa gagtggaaac agacacgttc ctctcagatc ttaaattgct tgctattgta
27721 ttgtgttacc tgattttttt ttactaaaat agttgacaca ggactttttg gggtgctgct
27781 tctctagctg gaggcctctg tggccggtgg tgcccctacc cgggtctcct gggctccagg
27841 gttggccctg gagtaccccg cccacctagc ccggccgtgg gatccgccct cagcccatgg
27901 ctggactgcg catgcgcacg ccgcaacccg cttcagcctt gagcactgga gtcYggacaa
27961 gaggagtgtg gtggcgcaca aaacgcccaa agatgccagg aacggcagag ccccaagggt
28021 gtcacagctc gattgttccc cccgcctgcg gtctggtgag tgggggtgtg ttacagtgtc
28081 accccccctt tttttttttt tgagacagag tctcactctg tcactaggcc agagtgcagt
28141 ggcacagtct cggctcactg caacctccgc ctcctgggtt caagcgattc tcctacctca
28201 gcctcccaag tagctgggag tacaggtgcc tgccaccaca cctggctaat tttttttttt
28261 tttttttttt ttttttttga gacagagttt ctctcttgtt gcccaggctg gagtacaatg
28321 gcacgatcgc agctcactgc aacctccacc tcccaggttc aagcgattct cctgccttag
28381 cctcctgagt agctggaatt acaggcatgc accaccatgc ccggctaatt ttttgtattt
28441 ttagtagaga cagggtttct ccatgttggt caggctaatc ttgaactccc gaccttaggt
28501 gatccacccg cctcagcctc ccaaagtgct aggattacag gcatgagcca ccacacccag
28561 ccagtttttg tgttttcagt agagatgggg ttttaccatg ttggccagga tggtcttgat
28621 ctcttgacct tgtgatccgc tcacgtcagc ctcccaaagt gctgggatta caggtgtgag
28681 ccaccaggcc tggccgtcac cccctttttg aatctgtgat tcagcaagtc ccaaatgctt
28741 ctcccatgtc caagaaaaat gaaggtatgc agacaaccgg agggtgagca ggacaacgtt
28801 ttgttgagca acagaacagt tctcagtgaa gaggggagcc aaagtgggca gcccctactc
28861 aaagttgggt acgcccccac tgaagtcccc caccatgcac agcctataat tttatctttg
28921 acttggcatt cttttttttt tttttgagac agagtcttgc tctgttgccc aggccggagt
28981 gcagtggtgc gatctcggct cgctgcaacc tccgcctcca gggatcaagt gttctcctgc
29041 ctcagcctcc tgagtagctg ggattacagg tgcccgccac tacacctggc taattttttg
29101 tttgtttgtt tgtttgtttt ttgagacaga gtcttgctct gttgcccagg ctggagtgca
29161 gcagcgcaat ctctgctcac tgcaagctcc acctcccggg ttcacgccat tctccggcct
29221 cagcctcccc agtagatggg actacaggcg cccaccacca cgcccagcta attttttgta
29281 tttttattag agatggggtt tcaccgtgtt agccaggatg gtctcaatct cctgaccaca
29341 tgatccgccc acctcggcct cccaaagtgc tgggattaca ggcgtgagcc actgcgccca
29401 gcctaatttt tgtattttta atagagacag ggtttcacta tgttggtcag gctggtcttg
29461 aactcctgac ctcatgatct gcctgcctcg gcctcccaaa gttctgggat tacaggtaac
29521 attcattttt aatgtccctc taacacaccc agactctccc tctgtatttt gagatgtaaa
29581 ttttgctatc tgatttttca cctaagagtt cttcctttgg tatgtcaatt tagggctatc
29641 aagctgaaaa ttgcctaaga caatgaaaca ggttatcaag aaattggaag tttaggccgg
29701 gcgcaatggt tcacgcctgt aatcccaaca aattgggagg ccaaggcggg cagatcactt
29761 gaggtcagga gttcgagacc agcctggcca agatggtgaa accccatctt tactaaaaat
29821 acaaaaatta gctgggtgtg gtggcacgta cctgtaatcc cagctacttg ggaggctgag
29881 gcaggagaat cgcttgaacc tgggaggcgg aggttgcagt gagctgagat tgcgccattg
29941 tactccagcc tgggcaacaa gagcaaaact ccatcttaaa aaaaaaaaaa tacaaaaatt
30001 agccgggcgt ggtggcaggt gcctgtaatc ccagctaccc aggaggctga ggcaggagaa
30061 tctcttgaac ccaagaggtg gaggttgcag tgagttgaga ctgtgccact gtactccagc
30121 ctgggtgaca aagtgagact ccaactcaaa aaaaaaaaga aaaagatcga aagaaagaaa
30181 ttgtaagttt aaaatagtag aaaaaaaaga aggggtctta tgcatcttct gtgtgtcgaa
30241 tgcatctatg tatctatgag tcatgtatac aatgtttcac taccaaaaat atataaaaga
30301 gttttaatta attgggttaa aggaaaaaaa agcacttaaa tactgtatca gaaaaatata
30361 aacttttttt tttttttttt tttttggaga cagaatgttg ctctatcacc caggctggag
30421 tgcaggggca cgatctcggc tcactgcaag ctccgcctcc agtgttctca cgccattctc
30481 ctgcctcagc ctcccgagta gctgggacta caggagcccg ccaccacgcc cggctaattt
30541 tttgtatttt tagtagagac ggcgtttcac cgtgttagcc aggatggtct cgatctcctg
30601 accttgtgat ccccccgcct cagcctccca aagtgctggg attacaggtg tgagccacca
30661 tgcctggcca gaaaaataga aactttaagc ccaaatgctt tttcaggttc atgtgactta
30721 agtaaatcct taaaaaataa gctagtttta aaattattgg taaaataaaa tagaaatgcc
30781 ttcagaattg tcaacataca ttattgttta gatttattgg taaaggagtt caatatttat
30841 cattacgaga tactgtaagt tgtcaaaatt tggcatgagg gttataaggc ttgcaacaca
30901 aaagggaatt atgtttgact aatttcttga taaataaggc atttaatatt gtttaatgga
30961 aagagataaa tcctgagttg ctggcaaaaa aaaaaagagg aacatttatt taaccataag
31021 gttcttactt aggtaaacac ctaaaattca caggctataa aaatggttag gccaggtatg
31081 gtggctcacg tctgtaatcc cagcaatttg ggagtctgag gtgggcagat cacctcagat
31141 caggaattca agaccagcct ggccaacatg gtaaaacccc gtctctacta aaaatacaaa
31201 aattagctgg gcatggtggc aggtgcctgt aatcccagct acttgggagg ctgaggcagc
31261 agaatcactt gaacccagga ggcggaggtt gcagtgagcc aagatcacac cattgtactc
31321 caacctgggc aaaaagatca aaagaaaact ccatctcaga aaaaaaaaaa aaaagaaaat
31381 ggttaacaga gaaataactt taaatgaaga ctatcacagt tttctttcct ttttcttttt
31441 tttttttgag aagagttcac tctgtcaccc aagctcgaac gcaatggcgt gatcttggct
31501 caccgcagtc tccgcctccc aggttcaagc tattctccca cctcagcctc ccaagtagct
31561 gggattatag gtgcccacaa ccacgcctgg ctaatttttt tttttttttt ttttgagaca
31621 gagtctcgct ctgtctccca ggctggagtg cagtggtgct atctcggctc actgcaagct
31681 ccgcctcccg ggttcatgcc attctcctgc ctcagcctcc tgagtagctg ggactacagg
31741 cacctgccac cacgcctggc taattttttg tatttttaat agagatgggg tttcaccgtg
31801 ttagccagga tggtcttgat ctcctgacct tgtgatccgc ccagtctggc taatttaaaa
31861 aaaatatttt tatagtaggc tgaggcgtga gaatggcatg aatctgggag gcggagcttg
31921 cagtgagccg agactatgcc actgcactcc agcctgggca acagagtgag acaccatctc
31981 aaaaaaaaat ttattttaaa taaacaaata aataattaca gatgtaaaga tagttataag
32041 gagatatttt tagtatgaaa agttaaaagg aaaataattt catatgagaa agaatcttgt
32101 gtggtaaatt tttgttctaa aatggctagt tattttggaa agagggatgt tcagaataaa
32161 acaggaagtc caagtatatc ataaatggtt tgtgtaagtt ttgataaagt ttgtaaaaag
32221 cttttttttt ttttttttaa gatggagtct cgctttgttg tctgggctgg agtacagtgg
32281 tgcaattttg gcctatgtca gattaacaag gctttcttgg agcattaacc cactctttaa
32341 ttaaaaaaaa aaagttataa aaatgtttat ggaaattatc ttttttgttt ttgaggcaga
32401 gtttcgctct tgttgcctaa gttggagtac agtggtgtga tctcagctca ctgcaacctc
32461 tgcctcctag gttcaagcaa ttcttctggc tcaggctccc aagtagctga gattacaggc
32521 gcccacaacc atgcctggct aatttttgta tttttggtag atacgtggtt tctccatgtt
32581 ggccaggctg gtctcgaact cctgacctca ggtgatcgac ctgcctcggc ctcccaaagt
32641 gctgagatta caggtgtgag ccaccgcacc cagccttatg gccttatttt ttttgttttt
32701 ttttagatgg agtcttgttc tgtcacccag gctgaagtgc agtggtgtga tctcggctca
32761 ctgcaacctc cacctcccag gttcaagcag ttctcctggc tcagcctccc aagtagctgg
32821 gatcacagac gcacactacc atgcctggct actttttgta tttttaggaa agatgaggtt
32881 tgccatgttg gtcaggctgg tcttgaactc ctgacctcaa gtgatccgcc tgccttggcc
32941 tcccaaagta etaggattac aggcgtgagc caccacaccc agcctgaaaa ttatatcttg
33001 tgctcaagat gattacaatt taatagattt gtttataaaa ttttagagag atttaattgg
33061 ccttatgctg tctttatctt ttgagaagaa attccctcaa agaataaagg tttctacatt
33121 tttttttgaa atctttgagt tatctcagca ccataggaaa ggtaaaaaca gaaaaaaaaa
33181 aagaaaataa aaaaagaaat ctgtgagtta tcactgtggc taagtgaatg acttatttta
33241 caatgacctg tgatcctatt tagtgatagc aactgtttta aaactttttc taggccaggc
33301 acggtggctc acacctgtaa tcccagcact ttgggaggct gagatgggca aatcaagagg
33361 tcaggaaatc aagaccatcc taactaacat ggtgaaaccc tgtctctact gaaaatacaa
33421 aaaattagct gggcgtggtt gcaggcgcct gtagtctcag ctgcttggga gactgaggca
33481 ggagaatggc gtgaacccgg gaggcagagc ttgcagtgag ccaagattgc agcactgcac
33541 tccagcctgg gtaacagagc gagactctgt ctcaaataaa aacaaaaaca aaacaaaaca
33601 ctttttatat ttgacaaact tKccaaaatc aaattctttc ttcagtcctc attaattttt
33661 gtgtgtgtgt gtctgatgga gtctcactct gttgccccag ctggagtgca gtggcacaat
33721 ctcggctcac ttcaacctcc acctcccagg ttcaagcgat tctcctgctt cagcctccca
33781 agtagctgga actacaggtg cccgccacca cacctggcta atttttatat atttttttct
33841 ttttgagata gagtcttgct ctgtcaccaa ggctggagtg cagtggcacg atctcagctc
33901 actgcaagct ccgcctcccg ggttcatacc attctcctgt ctcagtctct tgagtagctg
33961 ggactacagg cgcctgccac cacgcccagc taattttttt tttttgtatt ttttagttga
34021 gacagggttt cactgtgtta gccaggatag tctccatctc ctgacctcat gatccacctg
34081 cctcagcttc ccaaagtgct gggattacag gcgtgagtca cctgcctcag cctcccacag
34141 tgctgggatt acaggtgtga gccactgcgc caggcctccc aaggtgttgg gattacaggc
34201 gtgagccacc gctccgggcc tcccacagtg ctaggattac aggtgtSagc tgctgcacct
34261 ggcaattttt tgatattagg tcccctgaag tccaaaaaga gatatatggc ttatttggta
34321 taatgaaatc atacaggaag cattgttaaa ggtgaaatgg tgtttttctt gggattatat
34381 ttatataaat gtgttgttag tgtgtgttcc aaaattgtat gagatgcctg tgattctgat
34441 acatcttagt atatggtatt agtagtaatt atgattatta tgtaaaattg ttgtatgcca
34501 cataagtaac caaatttgct tgtcaattat gtcttttttt tttctttttt ctgagacaga
34561 gtcttgctct gtggcccagg ctggagtgca gtggtacagt cttggctcac tgcaacctct
34621 gcctcccagg ttcaagcgat tctcatacct cagcctccag agtagctgga ctgcaggcgc
34681 atgctaccac ggccagataa tttttgtatt tttaatagag acggggtttc tttttttttt
34741 ttttccctga cagagttttg cttttgttgc ccaggcttgg agtgcaatgg cgcgatcttg
34801 gctcactgca acctccactt cctgggttca agcaattctt ctgcctcagc ctcccaagta
34861 gctgggatta caggtgtaca ccaccatgcc tggctaattt tgcatttttt tagtagagac
34921 atggtttcac catgttgatc agggtcgtct caaactcctg acctcaagtg atccacccgc
34981 ctcagtctcc caaagttttg ggattataaa tgtgcgccac tgcacccggt caagacaggg
35041 ttttgccatg ttagccaggg aggtctcaaa ctcctgacct caagttatcc gccctgcttg
35101 gtctcccaaa gtgctgggat tgcacacatg agccactgtg cctggcctca attatgtctt
35161 taactgtggc tgttctaaga cttttgtcat ccacaattgt tgttttactt ttatcctttc
35221 acagagcagt ttataatcag ctatagaact ctgaggtact cttcaatcta agtttctgat
35281 cacttttgag attgtgccat tggaatagag caaaaaactt ccaagactct cattgagagc
35341 tgctatattc atgaggattg ttcatccaat attgggcaaa atgagagtta attttatgga
35401 ctaaactaat ataagactga aataatcttt ttatgttttt gcttaaaaca ttactgattc
35461 tttctgttct ttcagaacca agaaaacttt tttttttttt tttttgagac agaatctcac
35521 tctgtcgccc aggctggagt gcagtggcgc catctcggct cactgcaagc tccgcctccc
35581 aggttcacac cattctcctg cttcagcctc ccaagtagct gggacztacag gcgcccacca
35641 ccgcgcccgg ctaatttttt gtatttttag tagagacagg gtttcaccgt gttagccagg
35701 atggtctcaa tctcctgacc ttgtgatccg cccacctcgg cctcccagag tgctgggatt
35761 acaggcgtga gccacggtgc ccggctggta acttttttaa ctttgagcta tttgcagctt
35821 ttagcaattg agtaaagtac actcctgtga ggaagatttg gaacatattt ctgttttctt
35881 ttttgttttt tatattttgc ttgggtagca tatttctttc tgatttctcc aaaaattggg
35941 aactatctgt gagcactatt taaaaaaaaa aaaaaaactt ttccctctcc cttcccctat
36001 ttgtattcta atgtcaatat aatgatgtgt gcacgtgcag taacaatctg ttttctcttg
36061 taataggaca tagagacact gcatatttta ccaaggcttt gactggaatg gcatgctttc
36121 aaatataaac agacggcttt aaggaatcag agttgaccta tagtgcccat caaagccctt
36181 gggaaaactg gcttcatact gtatccaccc agtggattct tcttgcccag atggagccca
36241 tgtatcaagg tagggaaact gcaatagaga aagggtttaa ttcacacaga gacaagtgaa
36301 tgggagacca gaatttgatg attactgaaa tcagtctccc caagaatttg gggactaggg
36361 tgttccaaag gtagtttggg ggaaggggtg gggtagcttg gcagtgggtg cttgctgctg
36421 atgggttgtg ggggcggggg gccatcgtag ggtgtgagac aggatcctcc cgtgtgctga
36481 accgcttctg ggtggggctg caggagtagt tggcaggtcc aggtggagcc atcatcagtc
36541 agtgggtcct gttggagccg taggtatcag acatgcaaaa aacccttgSg aggtactgca
36601 aaaggccaat cttaggttac aatagcattg ttatctgcag gacctctgga ataatggctg
36661 ataattgttt atgtctacat cttagccaaa ttcaggctcc tctcctctcc ctagcctggt
36721 ggcccctcat tagttttaca aatacagttg agttttgggg aggggctatt atcatgtaaa
36781 ctataaacat ctcccaaagc tagcccaaga ataactgaag gcagcttgaa ggctaaaggt
36841 caaagggggt ttggctacat cagatcttcc ccaattggca taattttctc aatgatacaa
36901 tttttgtggc cgggctcggt ggctcacgcc tgtaatccca gcactttggg aggccaaggc
36961 gggcagatca cgaagtcagg agattgcaac catccttgtc aacacagtga aaccccgtct
37021 ctactaaaaa tacacaaaaa attagccggg cgtggtggcg ggcgtctgta gtcccagcta
37081 cttgggaggt taaggcagga gaatggcgtg aacctgggag gcggagcttg cagtgagccg
37141 aggtcgcacc actgcactcc agcctgggcg acagagcaag actccgtctc aaaaaaaaaa
37201 aaaaaaaaaa aagcctacat ggtaaatatt tattcttgct acagtttata caaataacca
37261 ggccaagtac aataagacta aaacttattt tgaaaacaaa tcagtactac ctgatttcac
37321 tttggtaaaa ataggagact agagagagaa aaattatgtt tcaaaataaa ctatagtata
37381 cctgttatta gattctagcc ttgcctaagg tttttcaact tttattattt tctctttttt
37441 tgtttgttta tttgtttttt cagacagggt ctcactctgt cacccgggca gtggtgtggt
37501 atcagttcac tgcaacctct gcctcctggg ttcaagtgat tctcgtgcct cagcctcccg
37561 agtagctggg attattggtg tgcaccacta tggccagctc atttttttgt atttttagta
37621 gagatgcgtt tcaccatgtt ggccaggcta gtctcgaact cctgacctca tgatccaccg
37681 gcctcggcct cccaaagtgc tgggattata ggcatgagcc actgcgccgg gccaaagccg
37741 tgcttttctt aaagctctgc gaacgaaagc tagacaactt aaacctcaga agagaataat
37801 ggtacctatt tatatacata aaccactttc acgcctgcct gctgtgtatg gacttcagag
37861 gaacacagcc tacgtcagtt ttctaggatt gttctctcca cgtgctcttt gttttctttc
37921 tttcttcttc cctctatttt cctccctccc tcccttcctt ccttcctttc acaaagtctc
37981 actctgttac ccaggctgga gtgcagtggc acgattttgg ctcactgcaa cctccgcctt
38041 ccgggttcaa gcgattctcc tgcctcagcc tcccgagtac ctgggactac aggcaaccac
38101 caccacaccc agctaatttt gttagtttta gtagagacgg ggtttcacca tgttggccag
38161 gctggtctcg aactcctgac ctcaagtgat ctgcctacct cggcctccca aagtgttggg
38221 attataggca tgagccactg tgcctggtca caacacctgc attttctttt ttttttgttt
38281 ttttttttga gacagagtct cactctgtca cccaggctgg agtgtagtgg tgtgatcttg
38341 gctcactgca agctccgccc cgtgggttca caccattctc ctgcctcagc ctcccgagta
38401 gctgcaacta caggcacccg ccaccatgcc tgcctaattt tttgtatttt ttagtggaga
38461 tggggtttca ctgtgttagc caggatggtc tctatctcct gacctcgtga tcgacccgcc
38521 tcagactccc aaagtgctgg gattacaggc atgagccacc acgcctggcc aacaccccca
38581 ttttgtatac cacactcaac tcccccattt tctacatgct gatcaaaacc aatctgaatg
38641 gagtctaggt ctggctgtgg gctgttggga aSaggccccc aaatctggcc atcaactggc
38701 cgcaaaactg gccataaaca aaatctctgc tgcactgtga catgctcatg atggccatga
38761 ctcccacact ggaatgaggg caaggaacac ctggcccacc cagggcggaa aaccgcttaa
38821 aggagttcct gaaccacaaa caatagcatg agcgatctgt gccttaagga cgtgctcctg
38881 ctgcagataa ctagccagac ccatcccttt atttcccgta agaagtgctt ttaatctata
38941 atctatagaa acaatgctta tcactggctt gctgtcaata aatatgtggg taaatctctg
39001 ttcgaggctt tcagcttcga aggctgtgag acccctgatt tcccactcca caccctatat
39061 ttctgtgtgt gtttctttaa ttcctctagc gccgctgggt tagggtctcc acgaccgagc
39121 tggtcccgca gtgggcagtg gtttgggccc gaccgagctg gtcccgcagt gggcggtggt
39181 ttgggcccga ccgagctggt cccgcagtgg gcggtggttt gggcccgacc gagctggtct
39241 cgcagtgggc ggtggtttgg gcccgaccga gctggtctcg cagtggtttg ggccctgctt
39301 gctcgactgg atttcaacag tgaagccaga ttagaggaca tgctggctgc cccgatcctg
39361 gacctggacc aatggtgctt cctaaacatt ccatgtcaac ttttcttttt ccaccttcca
39421 gggctgggct gtgaaagaga ttggagaggc aggtgcctgt gagagaagct tctaccagcc
39481 tgggaagtca ggtcttccat gagtgagggg aggtatctac tttgccaaac cttgttagRg
39541 aatgctgaca tagctgcctc ttcctgccca gaagctaagc ttgaatgcca cccctcacag
39601 agcttctctc ctgtctttca ctcactcctg cttatttctg tgacagaact tgacagcatg
39661 gacattgcca cttgcttcct tcagtctcct ggagtcccca tgtcctgaac acagaggagg
39721 cacccaaatg cttgctgaag ccacatccct ggaccaagtg acctgaccct cacctggagg
39781 accttcacct tcacctctca cctggaggac cctctcacct ggaagactct ctcacctgga
39841 ggaccRcccc acctgaagga ctcccaactg gaggaccctc ttacctgggg gaccccctcc
39901 gctggaggac cctctcacct ggaggaccct cttacctgga gggcccttca cctgggggac
39961 tcccccacct agaggatcct cttacctgga ggtcccctca cctggggaac ccccccccca
40021 cctagaggat cctcttacct ggagggccct tcacctgggg aacccccccc ccccacctag
40081 aggatcctct tacctggagg accccccacc gagaggaccc tcccccccca cctggaggac
40141 ctccccacat gaaggactcc cacctggagg accttcttac ctgggggaac ccgtctcacc
40201 tggaagacct tcacctgggt aatcgccgtg gcctcccact acggcgcagc cgggtcggct
40261 gcccgggctt caccctaaaa taaggcccga actgcagcag tcggagccga tccctggagc
40321 ccagcgccta gggcggaccc gcgggagcgt ctcttggtaa ccgttgctaa ggagaSgaag
40381 cccgggaagg agctttcgcg cctgcgccgc ggggccgtcc gcgtctgcgc ctgcgcgcaa
40441 gagaggcggg gccagcgctc ggcatggcgg agccagatct ggagtgcgag cagatccgtc
40501 tgaagtgtat tcgtaaggag ggcttcttca cggtgcctcc ggaacacagg gtgcgcgggg
40561 tgccacccgg gcagctctgc ccgcctcgct agcggcactg cccggctggg tctggggagc
40621 ctcgtgtcgc gctgccgcgc cgaggcttcc ggcacgggcg ggaacgacag tcccagagtt
40681 ccccgcggcg ggggcggaag ccggggcggg gcgggctcag gacccccgac agccggtccc
40741 tggagatctg aggggccggg gcgggctcag ggatgcctcg Mgcccgcgga gagacgggcc
40801 cgggacttgg gaagagcaag ctccgggatc cagctcgggc gctgctgggt tcagcgcccg
40861 agctgggctt tgcaggctga gccgcgagcc acttgtttgt ggggagaatt tacaYccgcg
40921 acgagttcga gcttgaaggc tcccgctggg cttgggctgc atggagcggg gtccagcgct
40981 gcctggcggc ttcacgcgaa ccctgggcgc gtcccttgcg gaggtgccgg tgcctccctc
41041 tgcagagacc aggagagagc ctctgggcgt tgggcggtgt tgcccaggtg cacggctggt
41101 gggggtggag agccctgaac tttggccgct ggtttgtgtt tttaactgct ggctggtgct
41161 ctgagaggcc aagccacgtg ttcagtaaga atcattaaca gatcgtggct ggatgacaac
41221 aggagecaca ctttactcat ccagacgtgc agcaggcgct caccgcgttg agagccgtgt
41281 gctggactct ggggtgaagt agtgagttgg ccttttcttt tttgttgttt ttttgagaca
41341 gggtctagcg ctctcgccca ggctggaatg cagtggcgtg atcacggctc agtgcatcgt
41401 cagcctcctg ggctcaagtg atcttcctgc ctcggcctcc caagtgctgg aattacaggc
41461 gtgagccacc gcccccagcc tggcctggca tttctttgag ttcaggaagt gtgacaagga
41521 tttggacacc cagaaataag cgtgtcgaga agagcacaag cagaggatgt gagaagggga
41581 attaaggcgg gaaagggagK ttgagactag gccatcagtg agtgacaggc cagatgcttc
41641 tgactcggtc cccaggtgtc aggaaggaat cagactgagg acaaatgcgg ccagtggctc
41701 acacctgtaa tctcagcaat ctgggaggct gaggtgggag gattgcttga gcccaggttt
41761 gatactgagg gttaagagaa gggaagccgg gaaatggggg ctgtgaggtt tcaaaccttg
41821 ctacgtgtgc tttttttttt tttttttttt ttgagacgga gtctcattct gtcacccagg
41881 ctggagtgca gtggcgcagt ctcggctcac tgcaagctcc acctcctggg ttcacgccat
41941 cctcctgcct cagcctccca agcagctggg actacaggcg cccgccacca cgcccagcta
42001 attttttcat atttttagta gagacggagt ttcaccgtSt tagtcagggt gctctagatc
42061 tcctgacttc gtgatccacc cacctcagcc tcctaaagtg ctgggattac aggcgtgagc
42121 cactgcgccc ggcttacatg tgcttcttag atccatggag aaggatacag actctactag
42181 ttcagagacc ccaaaataca gggcctcaag atgatgcctt ttttcactct cccctaacat
42241 tctggagaga agcagttgtt ttgcacaggt gggtcaggca ttctggttcc attttttctt
42301 cccgtcactg aggtgagaag aggtgaaagc ttcctttcac ctggaagtca cacggtccct
42361 tcagctcaca ttccaaggcc agatgccact gggtagcgtt tcataacttc caggaggtag
42421 tgatacaggg atgctgggac agcagcctct gccacagatg tatttttgta tgtgggattg
42481 aaagggagta tctgagtggc cgcctctgat atttctttca aagcattggc ccagtatcgt
42541 caccaccttt tctcatcaga Raagcccaag aggccgggta cggtggctca cgcttgtaat
42601 cccagcactt tgggaggcca aggcgggcag atcacttgag gtcaggagct caagaccagc
42661 ctggccaaca tggtgaaacc cagtctctac taaaaataga aaattaggcg gttgtggtgg
42721 cacctgcctg taatcccagc tactcaggag gctgaggccg gagaatcact tgaacccagg
42781 aggcggaggt tgcagtgaac catgttcttg ccactgcact ccagcctggg caacagagcg
42841 agactcagtc tcaaaaaaag aaaaaaaaag cccaaacgtg tggttgcctt tctgtttggt
42901 gagcaagacg tgagtgggct ccctggtaca aattccattt gaaatttcct cagttgttcc
42961 atcagctgcc aaatttccac actggcaaca cccttctgtt tcagctggga cgatgccgga
43021 gtgtgaagga gtttgagaag ctgaaccgca ttggagaggg tacctacggc attgtgtgtg
43081 agtggccaag gctaggacat gtggccgcag ctcgtggctg tgacagtgtg ggacgagact
43141 gtcgaagcag cagccgcgtt ggggctggaa gggactcaga ccctgtgctc tgaaacaggg
43201 cagaaacctg ttcaggaact tcaattcctg atgtagttat cacaaacRtt gtaccatttc
43261 tgggtaaacg taagcatccg gttgctaatg cccataatcc aaacgtgtca ctgcagagta
43321 cacagaactg ttagagaaat aaaatacaga actttccaga agcagcagga gctggacatg
43381 gtgctcatgt ctatcacctc agcaactctg gaggagtcac ctgagcccag gtgttttttc
43441 tttttgtttg tttttgagat gggtcttgct ctattgccca gactggagtg cagtggcatg
43501 atcatagctc actgcggcct cgacctccta ggctcaagtg atcctcccac ctcagcctcc
43561 tgagtatctg ggaccacaag agtacataag cacacccagc taatttttaa atttttggta
43621 gagatgggat ctccctatgt tgcccaggct ggtcttgaac ttctgggctc aaatgatcct
43681 cctgcctcgg cctcccaaag cactgggatt acaggtgtga gccactgcac ccggccaagc
43741 ctaggagttt gaggctgcag tgagctgtga tcacgccact gcaccccagc cttggcaaca
43801 gagtgagacc ctgtctcRaa aaaaccaaaa acaccacaca caactaaagg ttataacaga
43861 tgtgaaattg gcgtaggtca ttctggaagc tgcacacatt agcaggatgt tttgtagagc
43921 catcttcaca caaaataagg tttgcttttt tctgcataga gtaccttatt tgcttttagg
43981 acattacaag agagcacaaa gcagtgatct gcatgctaag gaggacatgg agagcctgga
44041 gccacagaac tgagtggctg gaggccaggg tccagcacag agcaaagttg ggcaccccct
44101 gcccagttca aaKgaggaaa ccctcNgggg gaacgcgtct cgggctaggg gcgttgcaca
44161 gagtggggac tgagtgtcac tgggcatgag gttgtcagag gaaagaacgg ggacccctgt
44221 ggctcaggga gagcctcccg ttcagcgcta gggagcccac gaggggcatc gagatgatgt
44281 catcaccaat gtgtttccat tccagatcgg gcccgggaca eccagacaga tgagattgtc
44341 gcactgaaga aggtgcggat ggacaaggag aaggatggtg agcaggaaat tggggtgttg
44401 ggacctcgca ctgggaggag gcagaaggat gtgagttacc tgaagtttcc tcagagcgac
44461 tgcacggtgc ttgtagcggg ggccggcctc tgggagggtt ctggtgtggc ccagcacatc
44521 acccccaggt ccacacgcag cctYagctgt ctgccaggag ggctctgcag tctccatccc
44581 ctcctccccc tcctgtctgg tgaggccacc tcactgcagg ctcagctctg ctgtcccctc
44641 cacccccagc acctgcctgt gcaggcaggg ccctgccatg ccccacatag atgtccacgg
44701 tgtttagaga ggtgccgatt cgtatttggt caaggaagag ttaaaagtgc ttattgggcc
44761 gggcatggtg gctcaYgcct gtaatcccag cactttggga ggccgaggca ggcggatcac
44821 ctgaggtcgg cagttcaaga ccagcctgac caacatggag aaaccccatc tctactaaaa
44881 atacaaaatt agccaggcgt ggtggcacat gcctgtaatc ccagctacta gggaggctga
44941 ggcaggagaa ttgcttgaac ccgggaggca gaggttgcgg tgagccgaga tggtgccatt
45001 gcactccagc ctgggcaacg agcgaaactc cgtctcaaaa aaaaaaaaat gcttattggg
45061 gtcgccccaR ttctccctga ggtggggaca ctgcagcacc tgctatcagg tgttcgtgaa
45121 gcccaagagt ggctggggtt ggggcttccc cgccatcact ggggtggggc tcgctgaggc
45181 cacctccctc cccaggcatc cccatcagca gcttgcggga gatcacgctg ctgctccgcc
45241 tgcgtcatcc gaacatcgtg gagctgaagg aggtggttgt ggggaaccac ctggagaggt
45301 acgtggtctc ctggtctgca cattgggccc tagggagcat gtgtcttggg ctagaggtgt
45361 tgcacagagc gaggactgag tgtcactggg catgaggttg tcagagaaga gatgacccca
45421 cctcaccgcc tggctcagcc cattgtctga gggggacaca ggttgtcctg cccatgtccc
45481 ctcctgcagc aggggaggct ccacttccac cccttaggag aaggccggag agtggcatgc
45541 atcttctgtt tcttccagca tcttcctggt gatgggttac tgtgagcagg acctggccag
45601 cctcctggag aatatgccaa cacccttctc ggaggctcag gtgcgtggca gaggggcctg
45661 gggtggggga atgggcttca tgggcccttg tggtgcacat ttataacgaa acagggcact
45721 tggggacttg aagagctgct gctgcctctg cctccacctc ccagtgtttc agcgagcttc
45781 agtgaggtgg aattcctgtg gtgggggcat ctgctgggag cgggcagccc cagggccgag
45841 agccttatga gggcactggt ttcctgggct gttgggagca ggcagccccg gggctgagag
45901 ccttctgagg gcactggttt cctgggctgc tgggagcggg gagccctggg cggagagcct
45961 tctgagggca ctggttttct gggctgctgg gagagtgcag ccccggggcc aagagccttg
46021 tgagggcact ggtttcctgg gctgctggga gcgtgcagcc ccggggccga gagccttctg
46081 agggcactgg tttcctgggc tattgggact gctagtcctg ctggccagtg tgggtgtggc
46141 agggcccagc tgggcttccc tgcaggctca ccctgactgg tacctctgac cctctgcaca
46201 ggtcaagtgc atcgtgctgc aggtgctccg gggcctccag tatctgcaca ggaactteat
46261 tatccacagg tgggtgacag ctaggcagag ttggaagcac aaattcggct gaggcctRac
46321 tctgctgccc ctgtggagtt actaaaagct caggggttcc cagctgcagc agcctgcccg
46381 ctgctcgcac tccatttgtg tttttttcta aaatagagaa ggggtctctc tgtgttgccc
46441 aggctggtct cacacacttg ggctcaagtg atccacccac cttggcctcc caaagtgctg
46501 ggattacagg tgggagccac cacacccagg catgcactcc gatttttaaa aggtccaaac
46561 atcaacagca tgtaagagtt aatgaaaaaa aaaataataa agatactacg ccgggcacag
46621 tggctcacgc ctgtgatccc agcactttgg gaggccgagg caggcggatc acgaggtcag
46681 gagatcgaga ccatccttgt taacacagtg aaaccccatc tctactaaaa atacaaaaaa
46741 attagccggg cgtggtggcg ggcgcctgta gtcccagcta cttgggaggc cgaggcagga
46801 gaatggcgtg aacccgggag gcggagcttg cagtgagccg ggattgctcc actgcactcc
46861 agcctgggcg acagagtgag actctgtctc aaaaaaaaaa aaaaaagata ctaaaaagcc
46921 caaagctgag gaaacgtgca ggaagtctac gggcattggt gccgtggggg agctctcagc
46981 ccctgtggcc ctctgggagc cacctgccac tgtttttcca tcacagggac ctgaaggttt
47041 ccaacttgct catgaccgac aagggttgtg tgaagacagg tgggtgcaac ttgggccagg
47101 ccctgtccct agatggcact tggtgacaca cactcccctc tctgctgcag cggatttcgg
47161 cctggcccgg gcctatggtg tcccagtaaa gccaatgacc cccaaggtgg tcactctctg
47221 gtaagtcctt ctgaagcatg gtggcccctg gggaccaggc ctgtctggtg gaggtctcct
47281 tggggatgtc aggccgaagc tgcaactggc cttgggaatg ttaagctaca gggtctgtgc
47341 acactcagaa acgttgggtc taggacagcc tccaggacac agcagggctg tgccacaaaa
47401 tggtgagaga cgggctcagt ggcgtcaagg gcctgcctag atcagacaca cctcgccttg
47461 agagctggaa acaccgtggc cgtgaaacca tctctggagg gaaggctgct tcacggactg
47521 aaggacaggc agcttgcatg ctttccctgg ttcttcctcc tggatacttt taaccaaaca
47581 gggtcatgct tagccagggc tgaatatcag agttggtcag aatcaggtca ggaccccagt
47641 gtcgtgtact ccccatctga gaacgggttg gtagtggctg gtgtggctgt gtgccgaggg
47701 tccgtggtcc ctgcgactct caggacaccg ctgcacgtga cagctctcgc ccccggcaac
47761 cattgctgtg tgtgccacct ggatctgcag ggcctggggc agagggtggt ccgagttggg
47821 acaggtttcc aggccaScac aggctctcgg ggaggctgtg tcctgtggag gcctgggctg
47881 ggggagagga gccggctgta ttgaggtggg tgcttctgtg tgtaggtacc gagcccctga
47941 actgctgttg ggaaccacca cgcagaccac cagcatcgac atgtggtgag gagataYggt
48001 taccgctcct ggggcctcag gaagggctgg gacaggagcc gggtcacctg gttcctgagc
48061 tcagcctcag gggaggggca ggagtgcagt ggggtctttg ccagcctccc actcccaggg
48121 aggtgggcct gagcctggaa acccaggagg aggtgtgaga acttagcttg ctgttctcag
48181 gctgggagca cagaggtctg gaggaggcac gcctgcccct gcacttgtca ccccgggagg
48241 cctgcggggc ccaggagggg agccagtggt ccctgcctgt ccttcacagt gtccctgacc
48301 cagSgtgcct cacactggca gggtcagcaa aggtctggct gcagtcaggt cctctgttcc
48361 tcgcgctggc ggggtcagca gacgtctggc cgcagtgagg tccactgttc tctgcagggc
48421 tgtgggctgc atactggccg agctgctggc gcacaggcct cttctccccg gcacttccga
48481 gatccaccag atcgacttga tcgtgcagct gctgggcacg cccagtgaga acatctggcc
48541 ggtgggcgtc ctgggcagac ccgcagcccc cgcccgtgcc cacgccctct gcgcccgcag
48601 cccccgcccg tgcccacgcc ctctgcgccc gcagcccccg cccgtgccca cgccctctgc
48661 gcctcagctc ctgcctccca tagggctttt ccaagctgcc actggtcggc cagtacagcc
48721 tccggaagca gccctacaac aacctgaagc acaagttccc atggctgtcg gaggccgggc
48781 tgcgcctgct gcacttcctg ttcatgtacg accctaagaa aaggtgctga tctctgcacg
48841 gggggcaggg accctcacca cccacactgt ccagaccgtt tcccagagcc cagcctcact
48901 gcggtggaga ggcccctccc caggcacagc cgctcggagt ggccacctgg cttcctttga
48961 gcatttgaat cacaggctgc tcagctgggt gggaggtgag gaagccgcac tcacaagtcg
49021 cactaacgca ggctgcctcc tccagggcga cggccgggga ctgcctggag agctcctatt
49081 tcaaggagaa gcccctacgt gagtgtgcag ggttcctgac tcgctctgtg gggtatggct
49141 gggagcccgt tttgcccggg gtgggtggtg gagaagtggc ctgctgccct cactgacggc
49201 acaccctttc tggggtaaga ggacaggggc atgtggaggc acagacagcc cagggccagg
49261 tccagaggca gagctggact cagacctggg cctgctcctc ctatctgggg ccctgccccg
49321 cccagcactg aacccttctc cctgcagcct gtgagccgga gctcatgccg acctttcccc
49381 accaccgcaa caagcgggcc gccccagcca cctccgaggg ccagagcaag cgctgtaaac
49441 cctgacggtg ggcctggcac acgcctgtat tcccacacca ggtcttccga tcagtggtgt
49501 ctgtgaaggg tgccgcgagc caggctgacc aggcgcccgg gatccagctc atccccttgg
49561 ctgggaacat cctccactga cttcctccca ctgtctgccc tgaacccact gctgccccca
49621 gaaaaaggcc gggtgacacc ggggggctcc cagcccgtgc accctggaag ggcaggtctg
49681 gcggctccat ccgtggctgc aggggtctca tgtggtcctc ctcgctatgt tggaaatgtg
49741 caaccactgc ttctYgggag gagtggtggg tgcagtcccc ccgctgtctt tgagttgtgg
49801 tggacgctgg cctgggatga gagggcccag aagaccttcg tatcccctct cagtcgcccg
49861 gggctgtccc gtgcatgggt tggctgtggg gaccccaggt gggcctggca ggactccaga
49921 tgaggacaag agggacaagg tatggggtgg gagccacaat tgaggatacc ccgagactac
49981 caggagagcc cYgggctgga ggctgagctg catccctgct ccccacatgg aggacccaac
50041 aggaggccgt ggctctgatg ctgagcgaag ctataggctc ttgttggata aaagcttttt
50101 taacagacat ggtttcacca gcgtttaatg tgctctgatg ttgaccgtcc ctctgagtgt
50161 tctggggagg agggggtggg gcggagggtc aggaaagcag gctcagcttc cagggtcagg
50221 gagttgtggg cccagagggg ctgtcacagt ggatgcaccY tgccctctcc ctcgccagac
50281 ccgagggtag ggcagaggca cctcctcgcc agcctgtggg ctgcacccac agggaatgga
50341 ggggaggggc accattacca ctggacccac caagaccccg ccgcctgggc gggctgtcca
50401 caggcccttc cgcccagcag cagtgacgct cagggccttc ccagctgtca gccactgccc
50461 gttcctgcgc ctctcgtgca cctccacatc tggtttgagg tcaggtcatt tcctgtctgt
50521 gggcccagct gctgtgacac ccaaggggag ggccggcgYc cccgaagcca ggtcagccgt
50581 gcacccggca gagccccgca gattggcYcc agcagagctt ggggtggggg gagctcggtg
50641 tcaccaacag gcccttgagg acactcgtgt ggagaatccc tgggacacgt ggaggacccc
50701 caaStcctga gccccgtact ccgtactgca gggagcaggc caggagccac gggccttggg
50761 gcacagggtc cttctcaggg acaggttcag gcactggctg gaacaggctg gacccctcta
50821 cccagcacat gtgggcatgc gtctgggttc cgagggtggg gaaatgtgga aaggctcctg
50881 ctggccggct taggcctgct gcccttggag ccttccatat acagagagtc ccacctccag
50941 caagggttgg cctggactct ccaWccccct gctgtgccca ggactccccc agggacaagg
51001 caaccagagg cccagacccc tccccagcaa agagaagcac cacgggagct gtctcccaag
51061 agcccttgac ctggggccca gctggcctag ggccgggccc cggggctgtt gtagagcaga
51121 gtgtccatct gtgcacgctg tagccacaag cgccgctggg cgtcgccaag cagcacacgc
51181 agcgagtggc ctggacggca ggcgggcagg gctgcacagt gggcagcatg cagctggcga
51241 caggtgtcgc agcagagggt gggcagggcg ccaggggaca ggcagctgtg tgcctggtag
51301 cctgggggct ccgagacaga cctataggct gaggctggta ccccctctgc ccgaatacgc
51361 ctcgggctgg ccgctgcaga gctttcaggg gtggccaggt ccccaggcct actcagctca
51421 cggcgcagag agaggaagga gaaggcggaa ggttcaggtt ccagcccctc ctccaaggcc
51481 ccatatggtg ggctgctggc ctgcggcagc tcctcagctg ggggctccca ggcccggccc
51541 ccagtgcccc acagtttggc actctgctcc cagagtggtg gcctgtaggc cagctccgcc
51601 gggggcgagt cagggcctgg tgacggctcc ccatacaggc tggcgtcctc cgacccctcg
51661 tcttcctgca agtcccggta taagtccagt ggggccctgt aagcagcagg ggagcctcgg
51721 gggggcaggg gtggcggctc ctcatcctgg gccagccgct gctgcagcca ggccacacag
51781 gaggccacgt ccccgctggc acgccgtgcc tgcagcagct cctcagctgg cagcacactg
51841 gtgcccagct gggccagcac ctcacccagg atctcacact ccagccggag ggcgaagcag
51901 cccagggcca cctgcaccag ctggcaggcg gggggcaggg cggtcaccat gagccgatgg
51961 ctgtctctgc gtacgtagcc catcttctgg aagctcttca ggaggaggtc gtctgagagc
52021 acacccttca gcacgtgcac gtagccccca gagaaggtct gcaagggagc ggccaggtca
52081 gtgactgccc accctcccat aggccagacc ctagggtaca gtgggtccgg gatctgttgg
52141 ctcaggcctt ggcagcttct gatgctcaga cccaacccca gagactaggc ttagccagct
52201 tgggccaggc ccaaacatga tgatttcttt tttttttttt tttttttttt ttttttgaga
52261 cagagtcttg ctctgtcatc caggctggag tgcagtggct ccatctcagc tcactgcagc
52321 ctctgcgtcc caggttcaag caagttcccc tgcctcagcc tcccgggtag ctgggactac
52381 aggcgcccac caccacaccc ggctaatttt catattttta gtagagacag ggtttcacca
52441 tgttggccat gctggtctca aactcctgac ctcaagtgat ccgcctgcct tgagctccca
52501 aagtgctggg attacaagcg tgagccactg tgcccggcct aRaatttttt tttttttttc
52561 ttttttgaga cagagtctcg ctctgtctgg agtacagtgg cacgatctcg gctcactaca
52621 acctcctcct cccgggttca agcgatcttc ctgcctcagc ctcctgagta gctgggatta
52681 caggtgcgca ccaccacgcc ccactaattt ttgtatattt agtagagacg gggtttcacc
52741 atgttgacca ggaaggtctt gatcccttga cctcatgatc cacccacctt ggcctcccga
52801 agtgctggga ttacaggtgt gagccaccgc acctggccga atttcttaaa tttaatggaa
52861 aaaacaatga atacattaac ctagctcaca aatcagaaca aaatgaagag cccctgtact
52921 gagaaattcc actgtcttct gtcccaccgc tcccttcacc cctggagatg gcctcatcta
52981 attagttttg aatgtacttg cccaggtgtt tgttttgcaa acccaaatac agatttcgtt
53041 tgctcctcgt atgaggtagt cccccctttt ttttcacctc tttgtaaggt ctctaaccaa
53101 agctagacag gtagcctctt aaacgtgttg ttctgaactt tgtttttttc cactacagtc
53161 ttgcagacaa ggacagaagc tgtaacgttc attccccctg ctgtgtagta ttccaccatg
53221 ggggtgacac gtctgttttc agcgctctcc agaggctgtc catgcactgg gctgacagcc
53281 gtgggacggt agaagggtga gtgctcNttt tttttttttt ttgagacgga gtctcactct
53341 gtcaccagga tggagtgcag tggctcgatc tctgctcact acaacctcca cctcccaggt
53401 tcaagtgatt ctcctccctc agcctcctga gtagctggga ttacaggcgc gtgccaccac
53461 acccagctca tttttgtatt ttttaataga gaYggggttt caccatgttg gttaggctgg
53521 tgtcaatctc ctgacctcgt gatctgccca cctcggcctc ccaaagagct gggattacag
53581 gcgtgagcca ccgcgcccgg cctggctgag tgctttctag cctacactta ggtgaagaac
53641 taaaggagct caggacaatc actgcgagcg tctcctgact ctcaaattcc ctaactccgg
53701 gactcctagc atctaatgcc tggacacggc ccacgtgtgg agcgcccagt gcctgcagca
53761 ctgagctcgg ggctttgatt cattcctctg gccccatgaa ctggactgtt cccgtgtcgc
53821 tgtctcagga ggaaaggggc tgacagagat tagctaattt ggccaagtcc tcgcggccag
53881 gaagcagcag aactaagtcc aaaccagggc tgtccSgcac tgaagccggt tattcccccg
53941 ccccgccccc tgggaggcct caagggcggg cctgtccgtc ctctctcatg aatgaaagtc
54001 ctggcgcctc cgaccagcag gtgtccccgg ggagccgcgg agagactgcc gctgccatgg
54061 caaccggcgg aggcgtagct cgcccacgtg cccagtgacg tcatcggctt cctactcttc
54121 cgaattagct cagagctccc ggcggccctg ccccctcctg ccgccaggag ctcacctgga
54181 gaggccaggc cagccctggg cacagcctcc cgccccaggc cgtggagttc actaggtctg
54241 agcccagccc tgagacttca cagggatgca cccatctgca gtcctcccag cctcggcggc
54301 ctcctctgca aatgggattg gcccataacc tggaggaatt aggatgacca tgggaactca
54361 agtcccttct gtgcccccgt cctaagattt ccatggcaac tggggccgcg aggcctctta
54421 gggaagacac tgacgcaagc tctcagggca ggaccccgta ggcagcaccc aagcctgccc
54481 tcgcccaccc catgttctca gccctaggag tgggtgcccc cacacgccca cgacccctca
54541 gcgctcggag ccttgaggag cccaccaggc actgaggaca cttgaagccc ctctctctcg
54601 aaaggcgtgg tcccccatgg tcggcggccc cgcgacccgc aggccaggac gaggggcgcg
54661 ctcctcctgg cctggcgcct accttgatgg tggtgaactc cttcctccag ggcagcaggt
54721 acaggtgcac cgcggcgagc tccagaagct cgaaggcgcg agccaggccg cgtagcgcgg
54781 gcgccaggtc ggcgcggccc cacagcccgt cggtgagcag agccagcgcg tcgtcctgca
54841 gcgccccgtg caggtcgaag tcctccacca ggatctgcca gagcaccgcg cgcagcgagg
54901 ggtccccgca cacgcccgcg cggccccgtc gcagctcgcg ctccaggcac tggcggtagt
54961 cctcggacag cgagctgctg cccatcctgc ggcggacggg ggtcgggggg gtcagggacc
55021 taaggccgcg cccagcccgc cgcgctctcc ccgaaccctc acccagcgtc cccaggaccc
55081 ctcgagcctg gagaccccgc ccccagcggc tgggcgcccc cggtatcttc ggcaccccct
55141 acgctggaga cctcggcccc atcagctgcc cgcccaccca gcgatccagg cccctccagt
55201 tgagcgcccc cgcacctcca gcccctccct ccagcctggg tacctcggcc ttccaggggc
55261 gcccccggtt atcgaccgca cccttctcta gagacgcgct tccgcccgct gagccctctc
55321 ccgaccagag ccccttcgcc cggcagatgg agctgcggat cccgcgggtg acggcgctac
55381 ctgtctgtcc ccagcggtct ccggccgccg cggatcagtt cgggcctccc cgcgcgccgc
55441 gcgcttccgc cgggagtcgg ctccgcccgg ggtccgcggc cgtgacgctg ggggcggggc
55501 ggggcttggc gcaggccccg cctccgaata atttaggagg ggcggggcct ggtgaaaggg
55561 gaggaggagg tgtcagcccg gccgagcccc tgcgcgaggc accccgagag cctcctgtca
55621 ccgcgtcgcc cgtctcctcg cgggaccggt atcgttcacg acgccgctgg gccgagggct
55681 gcgggctcat ggcaggcgct cagggaacgt tgtgcctggg ccgctcctcc ccacgagaca
55741 gggacccagc cccaggcgac ccggccgcgg ggaagcaggt gcgcgggctc gtcccctggg
55801 gggtggggcc accggcatta cctggcgggg attggctgga tcctgggaag agcctttcct
55861 gcggggcggg gccacctgca ttacctggcg gggattggcc ggatccgggg gcgggcctcc
55921 cctgtggggc ggggccatcc ccttgaggga ggggcccgcg gcacggaagg tgggcggaag
55981 gacaagcctt tcagcctcgt ctgaaacagc agcctcaggt ggatgcgggg acctcagatt
56041 ctgtttatgc tggctccgct tcccggcctc ctgcacttgc catctgcagc ccttgagagc
56101 atcgtctggg cgggtctctg aggcagggcg aagccgcccc cctctctagg ctaaaagctg
56161 acctgggctg cggatccacc caggctaaat ctgggccacg acttcccggg gacgttttct
56221 tcgctcgggt tcctctgttc tgtgctacag ccactttctc gcattgccca gaagtagagg
56281 aggatgaggg agacccttgg aggtcccagc cgaaacccac ccctacccca cacccccgct
56341 ttgggcaggc tttgctactt cacgtctgtg tccctcatct ctccaggcca ccaaaaccaa
56401 ggcccaagtt tgttgaaact ttccctgggc ctgggcggcg aggtcccccc tttttcttag
56461 attttttacc tggaagttcc ctgctggcat cttagaaata gtgatcatga ccgggtgcgg
56521 tggctcacgc ctgtaatccc agcactttga gaggccgagg cgggcggatc acctgaagtc
56581 aggagttcaa gaccagcctg gccaacatgg tgaaaccccg tctctattaa aaatacgaaa
56641 gttagccggg cgtggtggca catgtctgta agcccagcta cttgggaggc tgaggcagga
56701 gaattacttg aacctgggag gcagaggttg cggttgcagt gagctaagat cgtgccactg
56761 cactccagcc tgggtgacag agcgagaatg tctggaaaaa aaaatcgtga tgcagtcggt
56821 ggatctccct gagttatcta ggtggccacc tctggacagg gagctctttt acttactgtt
56881 tactgaactc actcttggtg cccagtgcca ccatgggtcc acaccagtcc tcaggacagc
56941 taacttcgta agtctcatct ttattcttct tctgatgcgg aggagggtgg aggtaactgt
57001 tctgcctttg tcctcactga atttggcaac accagtccat ccatccagca gtgggcctag
57061 ctctcctccc ataggcctgg gtgggttttt gcacctgcct caacccatgg aatagaactg
57121 atgtggaatg aattccaagg ctaaatcata aacatgccat accctggcct tgtcttgaga
57181 tccttggcct ctgacatggt ttggttctgt atccacaccc aaaatctcat cttgaattgt
57241 aatcccacag gtctggagca ggaccaggtg gagataatta aatcttgggg gcagcttcct
57301 ccatgctgtt ctcgtgatag tgaattccac gagatccgat ggttttataa ggggttctcc
57361 cctttgttca gtgctcattc tcgctcctgt cgccctgtga ggagacgcct tctgccatga
57421 ttgtgagttt gctgaggcct tccccagcca tgcggaactg tgagtcaatt aaacgtcttt
57481 tctttataaa ttatccagcc tcaggcagct atttacagca gcatggggac ggactaacac
57541 accctcagaa cccagccact agagtgagaa ggccacggcc gtgtgcagag cttttggcct
57601 gcaacttcga cctgcgactc acattcacct gcagcctatt cttgggactt ttttggaaat
57661 agtttttcca gacaaaaatc aagatgagtt tgttctgggc cgagcgcagt ggctcacgcc
57721 tgtaatccca gcactctgga agaccgaggc aggtggatca cgaactcagg agatcgagac
57781 catcctggct aacacactga aaccccatct ctactaaaaa atacaaaaaa ttagctgggc
57841 gtggtggcgg gcatctgtag tcccagctac tcgggagact gaggcaggag aatggcgtca
57901 acccaggagg cggagcttgc agtgagccgg gatcgcgcca ctgcactcca gcctgggcca
57961 cagagcaaga ctctatctca aaaaaaaaaa aaaaaaaagg atgaggttgt tctgggttgg
58021 catgggccct caatccagta tgactgctgt ccttatgagg agagagaaac ttagatatga
58081 acgcacagga gagaagaccg cttaaagacg gaggcagagt ggaacgaggg tgccgtgagc
58141 gaaggtaaca cagctgtgtt agagccacca gaaactggag gcaaacagaa ttctacccta
58201 aagcctccag agggagtcag ccctgctgac agcttgattt tgacttcagg cctgcaagat
58261 ggtgagagag aacatttctg ttgctgtaag ccacccattt tgtggtcgtt ttggcagccc
58321 ctggcaacac atccagtcct cacgtcgtcg ttccgacagc cctgaatgag gtcccagccg
58381 acagctggca ccaaccatag acagcagaca gctcttcgga tgaatccaac ccctggtcat
58441 tgggttacca cctagaaaca gcctcccatg atgctgagga gccatctggc tgatttttgt
58501 actttttgta ttttcagcag agacagggct tcactatgtt ggccaggctg gtctcaaact
58561 cctgacctca ggtgatccac ctacctcggc ctcccacagt gctgggattg caggcgtgag
58621 ccacggtgcc cagcctaatt tttaactttt tagtagagag gggggcctta ctatgttgcc
58681 caggctggtc tcaaactcct gggctcaagt gatccccccg cctcagcctt ccgaagtgct
58741 gggattccag gtgtgaacca ccatgcctgg cgtcttgagt atttaagccc ctgagttggg
58801 gtagtttgtt aggcagcggt ggctacgtgg gctgtacaca ttcacggctc cctcccttcc
58861 tgcccgggga tggacactcc atgagctgcc gtgtggattc tccgtccttc cctgccctcc
58921 cgggacagac actccattgc ctccactgca tatacatcct ctaaaaccgg cagcagcctt
58981 gccaggtcgg aggttccgtc cacacttacc tggactccag gactgcacct ggtcccctgg
59041 ggccactgcc gtgtccaccc cacagtgtgc gtgagctccc tccccctcct gtactcagca
59101 tcgtccagct tcctcatctt ctccggtcca atggatataa ggttacatct tgtttacttt
59161 tcatttgatt tttgttatga tttggacact gcttatgcag aatagtttta tttttatttt
59221 tttttagatg gagtctcgct ctgtgctcag gctggagtac aatggcgtga tctcggctca
59281 ctgcagcctc tgcctctcag gttcaaacaa ttctccggcc tcagcctcct gagtaactgg
59341 gactaccgcc accacgctca gctaatttat gtatttttag tagagacggg gtttcgccat
59401 gttggccggg ctggtctcga actcctgacc tcaaaagagc cgtccgcctc ggcttcccaa
59461 accgctgggg ttacaggcat gagccactgc gcccagccat tactttttat tttattttta
59521 ttttttgaga cggagtttct ctctgtcgtc caggctggag tgcagtggca cgatctcagc
59581 tcactgcaac ctctgcctct caggttcacg ccattctccc gcctcagcct cccgagtagc
59641 tgggactaca ggtgcgggcc accacgcccg gctgattttt tgtattttta gtagagacgg
59701 ggtttcaccg tgttRgccag gatggtctYg atctcctgac ctcgtgatcY gcccacctYg
59761 Rcctcccaaa gtgctgggat tacaggcgtg agccaccgcg cccggccatt tgtaggattt
59821 ctaaaaggaa gctgctatta ttcattcctg tcttatgggg gagctgcagg ctcagcgagg
59881 gcaaagctgc acagcaaaca gcagcacttg aacatgtctg ccgggtctca gcgccaggga
59941 tacagctgag ccaggacgtt cccRgccccc acagtgtgca ggctgcaggt gtggccccga
60001 tgccaagcca gcaggggctc ccacgccagg atttgttcaa gacacagctc atctccacca
60061 ttctatgaag cggactttaa aatcccatct tctagacacc aacgctgagg ccggagcagc
60121 ccaagctcca aggcaccgtg gccagctggg gttcgtatcg agggctgggg cagatgctcc
60181 agctctgccc cacccagaga gacacttctg tctccctatg gggtccttgg cgggtaaacc
60241 agcccctgct Sagggtgcaa gcacagagca tcccaccgag gtccacagct actgctttta
60301 agactgtttc cctgagaaca gcaacactgc cccccagcca gctcctggta gcatctaggg
60361 ttgggacctc ccaccccacc agccctgcca cctgcctcct catggcatct caaggtgcca
60421 ggggtgcctt tcttgcagaa gagccctcca tcctgatctg cccacaccgc cctggcagat
60481 gctgtccacg cccggcagcc ttctgtgcac ctcagagcat gtgtgtgtcg ccatgcacag
60541 aacgatgatt cctgagaccc tcgggtgact gctctgggct caggtcccca gtgatgacct
60601 ggaccccagc ctcaccccac ccttcccacc cactgatgcc ctgcagagct ctcctgtcca
60661 agagggtgaa gcccacacct gcctggccag gcacagcccc aagaggaccc tgcttctatg
60721 cagagggtct cggaggctgg cagatgttca agaggttggg ccaggcttgg tttggggctg
60781 ggctgtggct cgtcccccac atcctcagcg gcctctgcca tgggcagcag gggtggttgt
60841 gctgcctggc cagtggggtg gggattgagg gagccacacg gcgaagcaca gcagtgagct
60901 ctttatttta ggctgggtgg gggcagcatg tgacagtcaa gagggctgac ccttgggctg
60961 cacggaccta gataagatgc ccagggtccc ggaatgttca cagcccacag ccaaggtgag
61021 taaggggcag ggaatgtcct gggctcagag cccgagaccc tgcaggggtg tccctgccca
61081 tcagcaaaca gcataccctg acaccagctg caccccaggc cccagccggc ccttgttcct
61141 gacccagaca agaaactagt tcatggggct acaactcccc ttctaggggt cagaggggag
61201 agaaactgga ctgccgtctc cactgctggc cggctcatgg ccccctcttc cctgatgctc
61261 cccaggagct gccccagcca gatgttcatc gctgagcctg cacccaccga agcccaaagc
61321 ttcccttctt ggcctctctg aggcctacac aggagagcag ggcctggttc ctcctggagc
61381 tgattcagcc ccattctgtc ggggcagagg tgccaacccc aagctccagg gtcagatgtg
61441 aggtgaggaa ggtgaagagc tggagagcac accacagtgg acaagccccc accatgtgca
61501 gagcagcgtg aggctccagg atggtcctca gtagatccca tggctccagg tgtaggagag
61561 acagccctgg gaggcgaggc caggccctgc agggaccctg ggctctagct gtactacttg
61621 gccaggcctc cccggggcag cagctccacg tagctcaggg cactctgcag tgatgtgagg
61681 cagtagccct cctctccgat caggtacctg catggatggc aggggcagcc ggtgtcatct
61741 Raacgaacag aaggataccc ccggccctcc agaaggtagt gtctgccctc ccagttcagg
61801 acctgggtgc tgagggtggg caggtggggc tgtcagggcg gctgggctag aggaggcctt
61861 tcccacccac tatgtgctcg tccttggacg gtagagccag ggatggcact ggatccttat
61921 cccctcccca ggcagatgct gctcagggga cagcccccag ctcctgctgt ctgggagagg
61981 ctgagctaag cgaagggcca cgggacatgt ggcagcaggc actctgcaca ggtggaccca
62041 caggggctgc ccgaaggcat ggctgtgacg gagccacacg ctaccctccc cagctgctac
62101 tgacaaccac cgtttaggtt gagggatgag gtccctgctc ttcgcacaga gacccccacc
62161 ctgacccgcc agggtctacc cctcgtggat gaactcctcc agggccgcgc actccgacac
62221 cagctgaggg aggccgctcc tcagcaccac gaaggacagg atgggcagca ggtcatcggc
62281 accactgtcg ggagggcata gcggccttgg gttggggcca ggagcctctc actccgcaaa
62341 cccagcagct gtggagccat cctggccgtg ctggccgcca tctctgtgcc cttctgcgca
62401 gaggcaccgg aaggcagctg ggcatggtga ggctgtccct aaagggagct cccgtactgc
62461 ggagccaggg ctgggcccac acggccctcc tgcttctaca gtgcagccag ctggcacaag
62521 gctaaggggc aggaagatag tccctcccgt gaccattgcc tttctagggc ccttcctccc
62581 tggccacacc tcgccctcct gggactcaca tggcagctgc agcgatgggc gggggcccgg
62641 cctggggtgt ggcctctggg gtggggcagt agtcttccgc acagacacag atgatccgca
62701 gggtccgcac tgcgccccag acagggtttc aggggcagtt aaccccgtcc agcagcctga
62761 gccacccctt ataccccgcc cacccaccca cctcctgatg tgcacggctg ggaagagcca
62821 cggtgaccct ggcgatgttg ctcagacacc acttttgttc tggtccccca acctccccac
62881 cggcacgtga caagagaagc tcagtggtga agacacaggc tccaggtcac ctactgggat
62941 gggagcctgt ccctccccct gactctcgaa cctgctgacc tatgcactcc agcttcttct
63001 gggggcagct ctccaggacc agcagtccga gctcctgggc cgccgcgcag taggggtagc
63061 cagtggcccc cttggcctca gggttctggg ggaggagctt ggtggggatg ccaatggcgg
63121 tggggggtgc attcctgtag agctccatgc tcctgctcag ggcagcctcc cgggctcggt
63181 gcacgctcct ggggcagaga gaggccaggc taagctgccc cagggacctt gccctgggga
63241 cagaagcagg gctgtggctg gagctcagtc ctggagaaaa ctggctatgt atctcaagca
63301 aaaagcccca gcgttgccaa gaccccaggc acgggagagt ggcaataatc ctacctgcaa
63361 actggaagcc cctgaggatg gcctcagggt aaagcacagg ctagggggag caaacacgag
63421 tcttggggat ggaggggagc agacagtgcc agggagcagg gcaggcctcc tgggggactg
63481 ggctggaaga cactaggcca cgcaggtggt tgtacagctg ggtccatacc tgtacagggc
63541 cagcagcaga ggccacagcg gggagaaaaa gggttcctca atgcaggcca ggcagcggtc
63601 cttggaggca gctgtgttta ggccttcgaa ggccagaagg gtcagcgaga gcagcctgtc
63661 tgctaggaac agagccgggg acgtccacag aggctcctcc cctgctgggt caagtggctc
63721 taagccacgg ggcctttctc cgcccaagaa acctctttcc accgccttca agcctcctgc
63781 acccacccct gaccctcctc ggcccagggc agggagtccg ggactggaaa cggtcaccta
63841 cagctgctgc cctgttgggc cagcagcctg agaagaaacc ggagaatgat ccttttctca
63901 aaaggggctt tacccaaaac tgcaggaacc agggaagact ttagatccaa ccccctgtgg
63961 gtggggaccc tgaccaagtt ccttagtgtg tgggcagcac agtgagaatg acgcctggac
64021 tgttgggcct ccctcagtgg ttcttagaaa actctgggct gggcgcggtg gctcatgctt
64081 gtaatcccag cactttggga ggccggggtg ggcagatcaa ctgaggtcag gagtttgaga
64141 acagcttgac caacatggtg aaactccgtt tctaccacac tgtttccaaa atgagaaggg
64201 ctgaggcgtg agctgggtgg atgtaagtct gatcagagtc tctgatcaac agacccttcc
64261 ccaaacagaa gcttgaaacg gaccaataag caggggtgaa gagctgcggc ggctctccca
64321 gggagggcct ggcctcacct acggcattgt ggatctcctc caccgcggtc ttcagctgct
64381 gcagctgggg ctccggctgt accccacggc cccggccctg ccgctcagac gtccccagga
64441 actgctccag gtcctcgaac gagctgtcct tgtctggcaa tccagatgcg gtgtccccca
64501 ggggtgaggg agaccccacg gggccgggtt ggagtggggg cgtgggggga ctgtcctggg
64561 gccgcggggc tgcgctgggc tcgggcgggg acagcatgca atggaggctc tgcgagggcc
64621 gcagccgtcg gcttccgggg ttgggggtcg gggggcagca gcctggggct ggcgcggctg
64681 ctctgctcac ggcgggatac agggcgctgt acacggagca ctgcagccgc ctcaggagct
64741 gcgcgatcgg gtggtcgggg aggctgcggg agaagaggac gtgagaacgc ggccagcctc
64801 ggcctctccg tggcatccac aggtgccgcg ctatgcccgg tttcagagaa gcgacttgca
64861 ttacctcctg acagtgaatg ttggaaagtc tgccccccgc ccccgctggg gaggttggag
64921 aagccgagga aacgccctca gcgcaaaggg agctgcagtg tccacgtggc cgggcacagg
64981 ctccctgtgt cagtccagcc cctctccggc acctggcacc aggcagaggt gcccaaggcc
65041 ggtgcgcagg ggctctgtgg ggcctgaagg cccagctacc tgagcaggtg tgagaccagg
65101 ctggtcacga gtgacaggtc ccccggattc ctcttgagct tggccttcca gtgcttcggc
65161 cagtcctacg ggacaggggg ccttgaagga aagcacggtg ggtccgccac gaccggacgc
65221 gcctcatctc ccaccagtgc cgacccctag agactgtggg agcccgtcct ggggtgcagg
65281 agacccagcg ccagcaggcc ccgcgacccg cccccgcccc cacccacacc cgagggaaac
65341 cttaggcgaa ccctgggcct gcaccctcgc tgggaccctc cctcctcgca gggaccctcc
65401 ctcctcgctg ggaccctccc acgcgacccc tgacctcgcc tcctcgctct gccccgcccc
65461 acgcagccct ggccccgccc cctcaccggg ccctcccacg ggcctctggc cccgccccct
65521 cactgccccc cacagcctct ggctccgccc cccacggggg cccacccagg cggctctgac
65581 cccgcccccc tcgctgggct cctcctacaa agcctgggcc cgtgggggac gcacatggtc
65641 ctgttcgtac tccaggatgg cggcgtaaag ggcccgctgc tcccgttcct ccggggtcag
65701 ggcgacttgg ctgcaaaacc tcctggggag aaaggcacgc ggtgggtgcc ggggccaggc
65761 cctccccgca gcggccccag gggcgggcag gagtcccacc tgttggcggc ctcctggagc
65821 cgcagccggc gctcctccat ctttctctgg agctgggtgc agagtcaagg ggccgagcgt
65881 gggatctgag cgggccctcg gttcccaacc ccgtcccaca cccggagagg ccgggacgtc
65941 ccagggacct cctctcggtg aggggctgtc cccaggtaag gcttctgggg cagaaggcag
66001 cctgcgctca agccaggagg gccgggccag agaacatggg ggacggcggc cgggccttcc
66061 cctgagaccc tgcctctgca aagcggggag cccctcggcc ctgtaccccg accccggaac
66121 ctccgctccc ctcgctgccc ccttctctgc ccttggctca aggccacact gagtttcccc
66181 tcggggacca ccagggcggt cagaaaggct gctgtctcct cccgggcttt ggcaatcact
66241 aggttctcca tcatctgccg ctgtagagag agggtctggg gggggaggag ggagtaaggc
66301 cgactcccct ctgccccgcg cccacgcacc cccaggccct ccctagcccc cactcaccag
66361 ggatgtcttc tgcatggcct ggctggggtc tagccgcgcc attcgggcct catacgcagc
66421 cttcagcttc tgattctgca gggaggcctc ctccagtggc gtcagctctc tggaaatgtg
66481 acaagctgct gtctagaccc caggaagccc agtggtgtct ggacaccaga ggagtctctc
66541 tcatcctccc ggattgctct gaggccagga ggtgaggaga aagaggaggg gagccatctg
66601 gggtgggctg caacatctgc cccttcttgc ctgcccttcc aaaacacagg ttttggccag
66661 gtgcagtggc tcccgcctct aatgccagca ctttaggagg ctaaggccgg gcggatcacc
66721 tgaggtcagg agttcgagac cagcctggcc aacatggtga aactctgtct ctactaaaaa
66781 tacaaaaatt agctgggcat ggtgcacact tgtaatccca gctactcggg aggctgaggc
66841 agaatagctt gatcccggga ggtgatgcag tgagccgaga tctggccact gcactccagc
66901 tggggtgata gagtgagact ctgtctcaaa aaaacaaaac caaaacaaaa aataacaaaa
66961 agaaagaaaa cacaggtttt ggtattgcca ggacttttgg tttttctttt tttctttttt
67021 tttttgagac ggagtctcgc tctgtcgccc aggctggagc gcagtggcgc aatctcggct
67081 cactgcaaac tccgcctccc gggttcatgc cattctcctg cctcagcctc ctgagtagct
67141 gggactacag gtgcccgcca ctatgcccgg ctaatttttt gtatttttag tagagacggg
67201 gtttcaccgc attaaccagg atggtcttga tctcctgacc tcgtgatcca cccgcctcgg
67261 cctcccaaag tactgggatt acaggcgtga gctaccgcgc ccggccggac ttttggtttt
67321 tcaagagaag ctggaccact ggacttctat ggagatccgt tatatgtgtt tggcaacagt
67381 atgaatcttg ttaaagcaag cttgtgcaac aatccgaggc tgtatgactt cgaatgtggc
67441 ccaacacaaa ttcctaaact ttcttaaaac atcactgagg gctgggcacg gtggctcacg
67501 cctgtaatcc cagcactttg ggaggatgag gcaggcggat aatgaggtca ggagattgag
67561 accatcctgg ctaacatggt gaaaccccgt ctctattaaa aatacaaaaa attagccggg
67621 tgtggtggca tgtgcctgtg ctccagcctg ggtgatagag actctgtctc aaaaaatcac
67681 tgaggttttt ttgcaaaatt tttttttttg agtcagtctc attctgtcgc ccaggctgga
67741 gtgcagtgac acaatctcaa ctcactgcaa cctccgcctc ctgggttcaa gtgattctcc
67801 tgcctcagcc tcccgagtag ctgggattac aggcatgtga caccacgccc agctaatttt
67861 tgtatttttt agtagagatg gggtttcatc atgttggcca ggctgatctc gaactcctga
67921 cctcaggtaa tctgcccgcc ttggccttcc aaagtgctgg gattacaggc gggagccact
67981 gcgcccagcc ttgcaatttt tttttttaag ctcatcggct gttgttagtg ttagcgtatt
68041 ttatgtgtgg cccaagacaa ttcttccagt gtggcccagg gaaggcaaaa gattggacac
68101 ccctgcttta aaggcactat gtgggtcaaa cagccagatt agtctgtgac ccatgaaagg
68161 aagaagtgtc ctgtctcctt tatacagttc ccaacagcca ctccaccttg aaagctttgt
68221 tccctcgtac cttcccactg tcagggacaa tggaggacaa ggaggaaagt cagagcctga
68281 cgcctggcca ccctgccctg aagccacatt gcagaaacaa ggggactggg aagccaggcc
68341 ccgccagagc aggggcagga ggagtggacc cttctcgtct ctcccacttg ggagtcactg
68401 ggctttttgc atttgtgtct ttgtatcttt catcagttct agacaactgt ctgccattct
68461 aacttctaat aatgcctctc tcccattttc tttcttcttt ttttttgagc cggagtctcg
68521 ctctgttgct aggctggagt gcagtggcac gatcttggct cactgcaacc tccacctcct
68581 gggttcaagc gattctcctg cctcagcctc ccaagtagct ggggttacag gcacgcgcca
68641 ccatgcccag ctaagttttg tatttttagt agagatgggg tttcaccatg ttagccaggc
68701 tggtcttgaa ctcctgacct tgtgatctgc ctgccttggc ctccctccca ttttctttct
68761 ggaactccaa cgaacacgtt aggctttcca tctcttgttt tctgtcttta ttttttgttt
68821 ctgtaattca ttctagctat cttttgacct tttttccaat acatgaattt gctcttcagc
68881 tatatctgct ctgctgttat aaacttgtct gctcagtttt gtatgtatgg atttctacat
68941 atatatagat atataactca tccttgttcc cagctaaatt tttttttttt tttttttgag
69001 atggagtctt gctctgtcgc ccaggctgga atgcagtggc gcaatctcaa ctcactgcaa
69061 cctctgcctc ctgggttcaa gggattctcc tgcctcagcc tcctgagtag ctgggactat
69121 aggtgcccgc caccacgccc agctaatttt ttgtattttt agtagagatg gggtttcacc
69181 ttgttggcca ggatggtctc gatctcctga cctcatgatc cacccacctc ggcctcccaa
69241 agtgctggga ttacaggcgt gagccaccgc gcccggtcat tttttttttt tttagacaga
69301 gtctcatttt gttgcccaag ctggagtgca ctggcacaat cacggctcac tgcaccctca
69361 acctgtcagg ctcaagtgag cctcccacct cagcctccct agtagttggg actacagggg
69421 cacaccacta tgcctaattt tttttgagac ggagtttcac tcttgttgcc caggctggag
69481 tgcagtggca caatcttcgc tcactgcaac ctccaccttc caggatcaag cgattctcct
69541 ggactcagcc tcctgagtag ctgggattac aggtgcacac caccacggcc agctaatttt
69601 tgtattttta gtaaagacgg ggttttacca tgttggccag gctggtcagg aactcctgac
69661 ctcaggtgat ctgctcgcct cggcctccta cagtgctggg attacaggcg tgagccacca
69721 ggccgcctgc atttgcttgt gtccggccag gggatattcc cattctggga ctcattttaa
69781 aaacattcgc tgtcaggcca ggcgcagtgg ctcatgcctg taatcccagc actgtggggg
69841 ccgggcgcgg tgactcacgc tgtaatccca gcactgtggg aggccgaggc aggcgcatca
69901 cgaggtcagg agatcgaaac catcctggct aacatggcaa aaccccgtct ctactaaaaa
69961 tacaaaaaat tagctgggtg tggtggtggg cgcctgtagt ctcagctact tgggaggctg
70021 aggcagaaga atggtgtgaa cccgggaggt ggaggttgcc gtgagccaag attgagccgc
70081 tgcactccag cctgggtgac agagtgagac tctgtctcaa aaaacaaaaa aaaaatcgct
70141 gtcatcagct catctttctc agcctcaaaa acccaatccc aggctcatcc cacctcccat
70201 cttgtccatc ttacttctta cagctttgtg actctgcccc ctgaagcttc tggaagatct
70261 cgggtggcag aaaaggagag agctttcctc cttcatcgga gtatacacgg cggtgtcggc
70321 cggcaggctg gggaatggga gcagctgcag gcatggttgg cttcaggcgt gttttccctg
70381 caagccatgg gtaaccaggg gtcaagcggt gggccacatc ccacagagga gatgcgggct
70441 tgggggatgc cccaggagag ccgcctactg caggagaccc accaagcttg gcggccgtcg
70501 actgggccct ctccagacac tgctgtgcta gcttcagcat cttggaggtg tcggggggca
70561 cagtttcccc agcttctggg ggagggacaa gaaggctggt cacagtcggc tctaccactg
70621 ttacttactg ctgagataaa atgaggcaac ggaaaaggca ggcaagccca ctgcccccct
70681 cagcaccccc actgaccccg ggcaagccca ctgccccccc atcccctcac tgaccctggg
70741 caagcccact gcccccccat cccctcaccc cgggtaagcc cactgcccct cccgtccccc
70801 aactgactga ccctaggcaa gcccactgcc cccccatccc ctcaccccgg gtaagcccac
70861 tgccccttcc accccccact gaccccgggc aagccgacta ttcctcatgg accccaggca
70921 aggcccctgc ccccaccatg gaccccaggc aagtcccccc acccacgcat ttctaatcat
70981 ctgccctggt tttgcctcct gagtctgcta aggctgtggg cccctcatcg aggcccgtca
71041 cagcctcgac cctaaacagg cctttagtgc tcactcagct tcacttgcaa ctgcaggcct
71101 ctgggaagtg gccgttttac agagacaagg acgtgctgag gggatcgcct cacccatctc
71161 ccaccggctg tgtccccaaa gtcctgcctt cccgtagctt ggcatggagc acctctgcgc
71221 gaccatggac ctgctcacac agcccttctg cgcgccgtgg gagctgcctc tctgtgactc
71281 gcccctggac ccaccgcccc agcgcctgac ccacctccct gctgcccttc acagaaaact
71341 tctcatagac tcccattttc tcatcccgcc ccgatttagc ccccgactcc ccccggaaac
71401 tgcccttacc cgtccccacc ttgccagaca cggtgggcca ctggagttcc tctgtcttct
71461 gggactttgc tctccccagg ggatcctctg ccactcctcc acccaactcc tcaatcttgg
71521 agcgccagag ctcagccgag ctcaccggct ccctagggag ctggggcaac tgttagctcc
71581 ccctgacctg tgtgatccta cgtccagtgg ctgccccgac ctctgtgatc ccacgtccag
71641 gggctccccc gacctctgtg atcccacgtc cagtggctcc cccgacctct gtgctcccac
71701 gtccagtggc tcccccgacc tctgtgctcc cacgtccagt ggctcccccg acctctgtgc
71761 tcccacgtcc agtgggtccc cctgacctct gtgatcccac gtccagtggc tccccctgac
71821 ctctgtgctc tatgtccagt ggctccccct gacctctgtg atcctttgtg cagcggctgc
71881 tggcctctca aacttaatgt gttcattgcg gaacttgcta ttcctctcct tgccagtttg
71941 ctcctgcccc atctgcctcc tgcaagtctg ctctgttcca ccttcaggac gcaccccgag
72001 gccgtttact gctcccatcc tgggtggtct ggccactgcc atcctcagtc ctcacctgag
72061 gctccactcc caggctgtcc tctccctcaa agctcaaagt ctcttcaagt ttccctgcac
72121 accagaacgg ccccagttcc acccaaggca tgcacacagc cccaccccgc ccactcctat
72181 ttcagggcct ttgcacaccc cacagctgga atgctgcccc acgtctgtgc cgctcactgg
72241 agccagtgtc ttgccacacc ccagtctcca tcttcttatc cacaacgctg gtcccttcct
72301 gccactatat cacactgagt gtgggctggt ccacctacta caaatggtca ggctagaagg
72361 atacaagaga cccccgccga agcctggcac ccatcaaggg ctaggatgcc cacaatttgt
72421 ccagcatgga ggaagcagca gggctcagcc atgccttttt ctttttcttt tctttttttt
72481 ttttttgaga cggagtttcg ctcttgttcc aggctggagt acaatggggt gatctcggct
72541 cactgcaacc tctgctcccg ggttcaagca attctcctgc ctcagcctcc cgagtagctg
72601 ggactacaga cacccgccac caggcccagc tgatttttta gatttttagt agagacgggg
72661 tttcaccatg ttagccagga tggtttcgat ctcctgacct caggtgatag cccgcctctg
72721 cctcccacag tgctgggatt acaggcgtga gccaccgcgc ccggctggct gagccgtacc
72781 tttagtggtt tccacttctt ctagtaacac ctgggagata tagtggatgc tcctcaggta
72841 ttccgtgtat gcctcctgtg tccaggaaag agaaagagtg gggtcaggcc agtggaggga
72901 agtgactcca ttattccggc caggtgccct tgtgggataa gcaaggaaca ccaccacctg
72961 cttatctctg agatacaccc agagacattg agcctgcggt ggttagctgc agccggaaca
73021 cggttttctg cgcagggcac aggcagcatc gctgctctcc agacttggaa aagacatcag
73081 gacctgagag agagagagag ccagggacga gctggacctc attttctcct ctgactgcct
73141 ttctctccag cacaggaact gatattctca ttcagtgggc ctggggaagt gacctcagca
73201 gtttgctgtc atttttcatt ctatgcaatg tttccttctt gtgcaactca agggtgattc
73261 attcagtggc ttaaaaaaat acttttctga gaggataaag ggagtgatac tggaagtttt
73321 caaatcactt cccggtttaa gttccgagaa atccctttcc cagaacctgc gagttacgta
73381 tttccagtgc acacaggagc ctagaactgt tacctttcaa ggctgtgtga cccctctgac
73441 aaggcacagg tcattggaac cacagaatgg tggtttgttt tgttttgttg agacagagtc
73501 tcactctgtc gcccaggctg gagtgcagtg gcaggatctc gagtcactgc aacctccgcc
73561 tcctgggttc aagtgattct catccctcag cctcccaagg agctaggatt acaggtgtgc
73621 accgccacac ccagctaatt tttgtatttt tagtagagac ggggtttcac cacgttggcc
73681 aggctggtct caaactcctc acctcaggtg atccaccgcc tgggcctccc aaagtgtcag
73741 gattacaggc gtgaaccaca gcgcccagca atatgctatg tttttttgtt ttatccctag
73801 ctgttaagtt tcctatcttt aagtctatgc ctcagagaga aagacgaaat ataatccagg
73861 caggatttct gacttgcggg ggcacctgct gccctaaaaa ccaacttggg gaaagcagca
73921 gattcaggaa cgaggcttct cctaggcaca ggcaggctcc ttccctcctt gggcagccgg
73981 gtgtggctgg gccagcttct ctacctggtc gccaacctta gattcggccc catctcagga
74041 acgggccaca cccctccggc ctgcttttcc ttcctaagac gactgcaaac agcatcacaa
74101 atgagcaggt atgtggcctt ctctgcatgc cgtcccctgt ggcaaccgga ttaaatctac
74161 catctctgcc cagaaaaatg cacgaacgca cggacctgcY cgtcactcgg attttggaag
74221 gtggcctggc ggaccctcct gctacatctc ctctacaggt ggagcccagg ctgtgatgca
74281 ccggctcagc gagcggagtg gaaagccaag gtccgcagga tctgagctgt ccaaggtcac
74341 tgcacgcccg gctgcgcccc gcccccgtcc tcgcccggga accgcggccc gggatcccgg
74401 ctggcgcccg ctcccaagtc tccagcccga gccggccccg tcctcgccct ccccgggcgg
74461 gggtccctcc aggggccacc ctcagcggcc aagccccgcc cccgccccgc ctcacccggg
74521 gccggttgcc ggtgtccagc tcgatggccc cgttggcaag cttcatggcg ctctgcagcg
74581 gcttcaccgt gccgtccccg gccgcagcgg ccatggcgcc gagcggggga ggcggcggcg
74641 gtagccgagg ggctggacgg gcgaccggag gcccggaacg cagccggcgc tggtgctgga
74701 gccgcccgag cagcggaccg caggaaggga cgcggccgca cttccggcga cgggccccct
74761 ccgcgcgtac tgcgggcccc acgggtgtta gtggcggggg cggcagagtc cgggtgggtt
74821 gtcgcgacgg agccgggcct cttcgccgtc ttgagacggg gctggcgaga agggcccctc
74881 acggagttgc catgggcgtc taaccgcggc agccaggccc ctctctacgt gagaccccgg
74941 cccccctccc ctttctgcag cccgcccgcc acctgcgcgc cgcgtggcct ccgccggcgc
75001 ctgcccgccc cgcgcctccg tctcccacgg taagaggcgg tgagggccgc gtcgcctctc
75061 cctggaggac tcgtcgtgag gtgtcggcga gcccctccgc ccaccgcccc gccccaggcc
75121 agcgctccat tggcgacaga ggcgggcacg gccgccctcg ggcccgagag gggagcggta
75181 cgagcggggg cgctggcacc gcgggtggaa cctcggccgg cggggtcccg cccctggccc
75241 ctggcccgcc ccgcccgcct cgctttgctt ctcgctccgc ccctcccccg ccccgcctcg
75301 cttccagcgc gccgagcgga gcctaacgcc gggtcctcta ggaacctcgg gccgggcagc
75361 acccgcggga ttctgctggc gtcctccgct gccatgaagc gggaccggct gggccgcttc
75421 ctgtctcctg ggtcgtcccg acagtgcggg gcctcggacg gcggcggcgg cgtcagccgg
75481 actcggggcc gcccttccct tagcggtggg ccgagggtgg acggggcgac ggcgcggcgc
75541 gcctggggcc cggtggggtc ctgcggggac gcgggcgagg acggcgcgga cgaggcaggt
75601 gggtccgcgg cccgggcgtg gcgggttggg gtcgcggcag gggttgctcg tgggaggagc
75661 cgcactgacg cccggaagcc ggcgcggcct ctcctccacc cggccaaggg cgtagcggac
75721 tcggggctgc gtcgggatag gcgctgggcg gccggctcgg ttttcctcgc gctccgtgac
75781 gccggcgtcg ccggcccggc ctccccggcc gcgggctcgg ccagaaggga cccggcgtga
75841 ggagcgctgt caccgcgggc aggtcgccct ggggtgcccg cgcgtgggaa tcgccctccc
75901 ctgcttcgtg ccctcgcgga gccggaaagg aggcggcacc tgcaattggc agacaggaaa
75961 ccgcggcgtt tcctggaggg cgcagcgcct gccccgggtc tcgcggtcgc tgggaggagg
76021 gtgcagttcc aggtttcact cttgaagttg cttcgctgga gaggccttag aggcctttga
76081 aatttgaaag atttcttgga ccagcggcca catcccccac agggcggctt gtcccgccga
76141 gagccgcgcg cccgagccgc ttgctgtgtc cgggagccgc gcgaagggcg ctgcaggcgc
76201 tgccctcgga cctggagtcc gggacgccct gtgctcagga gcctcctttg ccagctgcta
76261 acacttcctg ccgctctgtg caggagcagg ccgggctctc gccatgggtc actgtcgcct
76321 ctgccacggg aagttttcct cgagaagcct gcgcagcatc tccgagaggg cgcctggagc
76381 gagcatggag aggccatccg cagaggagcg cgtgctcgta cgggacttcc agcgcctgct
76441 tggtgtggct gtccgccagg accccacctt gtctccgttt gtctgcaaga gctgccacgc
76501 ccagttctac cagtgccaca gccttctcaa gtccttcctg cagagggtca acgcctcccc
76561 ggctggtcgc cggaagcctt gtgcaaagta cgccctagtc tgttcagagc acgttcaggc
76621 tgtcagtact gcagtgtgac gggtgttgag agagggacag ggcgtgcctc cgcgggagcc
76681 tctgggtggg gggaatgggc catgcccggg ttcagtgcca acagccctgg gactgttgtg
76741 gagagatgaa ctgggaggag ctggggtgag ggaagagaaa gttgcctatg gggaccgctg
76801 aggtttgaga tctcgagagg gtcccgtacg acgagcgctg tgaacctccg cctgcttgtc
76861 ctgctcatgg ccacactgat cctttgcagg gtcggtgccc agcccccaac aggggcagag
76921 gagggagcgt gtctgggtga gtcctccccc ggtggagggt gggctgggtg ccgaccagcc
76981 gtggatctga catctctgtt gactctctgc agtggatctg atcacatcca gcccccagtg
77041 cctgcacggc ttggtggggt gggtgcatgg acatgcggcc agctgcgggg ccctgcccca
77101 ccttcagagg acactgtcct ccgagtactg cggcgtcatc caggtcgtgt ggggctgcga
77161 ccagggccac gactacacca tggataccag ctccagctgc aaggccttct tgctggacag
77221 tgcgctggca gtcaagtggc catgggacaa agagacggcg ccacggctgc cccagcaccg
77281 agggtggaac cctggggatg cccctcagac ctcccagggt agagggacag ggaccccagt
77341 tggggctgag accaagaccc tgcccagcac ggatgtggcc cagcctcctt cggacagcga
77401 cgcggtgggg cccaggtcgg gcttcccacc tcagccaagc ctgccccttt gcagggcccc
77461 aggtaggagg cacctcttgc tggtgctaga ccaggatgtg tgctcctcag tSgggcaggg
77521 ttttcagcag aaagtgaatg tctccactgc tctaggtggt ggctggggtg tggtgtgaga
77581 aggagcagag cttggggctt ctgcctgcgg ctgctcacca catccagaga gcagggaggg
77641 gcggccagcc tgtctccgcc tcttgctcct ctgtgagcag ggctctgttc cagcagtttc
77701 tgtggagaca cgctcatcag ccgtcgagtc tttttctaag cctgtgcttg gggctgaggg
77761 gactgaggaa gagggaagaa tagggccttg tctgtggatg tgggagaaaa gaatggccgt
77821 tgcctctgcg gctgctgccc tgggccagct gcaggtcatt tcctggcact cagccagccg
77881 cctggtgaca ccctggtgtg ggccagtgtg gcgcagcttt ctctgctgac aggctgaggg
77941 gaaacacaag gcccttgttt gggccccaga acccatagca ctgtgggctg gtgcagctgc
78001 tcctggatgt tgttttagga gggccagggc cagtttccct ccggcctctt gtcctgtgtg
78061 tgctctgtgc acctgtcccc acctgagcac tcagttccca ctttgagtct tgaggggagc
78121 ttccgaaaag cgtagctacc tgtaatccca gcactttggg aggctgaggt gggtggatca
78181 cttgaggtca cgagatcaag accaacctgg ccaacatagc gaaaccccat cgctaataaa
78241 aatacaaaaa ctagccaggt atggtggtgg gcatctgtaa tcccagctac tctggaggct
78301 gaggcacgag aatcacttca gcctgggagg cggaagttgc agtgagccga catcgcacaa
78361 ccgtactcca gcctgggtga cagagcaaga ctctgtccca aacagaaaca cagctaccca
78421 gatagtttag ctagatacgg gtgcacagat gagacagtgc ggctcggggg cctcaggtag
78481 gaacgggatt gtgagtgtca catcttagag ctgcttggct ctgtaaactt gtatgcagtg
78541 tgttgagaac aattctatct atctgtgtat ctatctacct acctacctat ctatcttcct
78601 acttctttgt ctctctctat ctacctacct atctgtatat ctatgtatct acttatctac
78661 ctatttatct atttatttac ctacttatct atctatctat gtgtttattt atttttgaga
78721 cagagtctcg ttttgtagcc caggctggag tgcggtggtg ccatcttggc tcaccgctac
78781 ctcagcctcc cgagtagctg ggatgacagg cacatgccac cacgcccacc taatttttgt
78841 atttttagta gagatggggt ttcaccatgt gggccaggct tggtctcgaa ctcctgacct
78901 cgtgatccac ctgcctcagc ctcccgagta gctgggatga cgggcacgtg ccaccacgcc
78961 cacctaattt ttgtattttt agtagagatg gggtttcacc atgttggcca ggcttggtct
79021 cgaactcctg acctcgtgat ccacctgcct cagcctcccg agtagctggg atgatgggca
79081 cgcgccacta cgcccaccta atttttgtat ttttagtaga gatggggttt caccatgttg
79141 gccaggcttg gtcttgaact cctgacctcg tgatccacct gcatcagcct cccagaatgc
79201 tgggattaca ggtgtgaacc accgcgccca gccaagaaca atacttttta aaacttattt
79261 taggccaagt gcagtggttc acgcctgtaa tcccagcact ctgggatgct gaggtaggcg
79321 gatcacgggg tcaggagatc gagaccatcc tgactaacac ggtgaaaccc catctctact
79381 aaaaatacaa aaaattagct ggatgtggct gtggttgcct gtaggcccag ctacttggga
79441 ggctgaggca ggagaatcgc ttgaccctgg gaggcggaga ttgcagtgag ctgagattct
79501 accactacgc tctggcctga ccgacagagc aagattctgt ctaaaaaaga aaaaaacaaa
79561 acaaagaaaa cttattttaa gtagagacag ggtctcactc ttttgcccag gctggtcttg
79621 aatttctgtc ttcaagtgat ccttctgcct tggcctccca aaaggctgag attataagca
79681 tgaaccttca ggcctggccg agagaacagt aatatttatt tatttattta tggagtctcg
79741 ctctgtcgcc accaggcctg gccgagagaa cagtattatt tatttattga tggagtctca
79801 ctctgtcgcc caggctcgag tgcagtggca caatctcggc tcactgcagc ctctgcctcc
79861 tgggttcaag tgattctcct gtctcagcct cccgagtagc tgggattaca ggcttgtgcc
79921 accacaccct gctaattttt ttgtatttgt atttgtattt gttttgagaa ggagtttcac
79981 tctttgttac ccaggctgga gtgcagtggc acgatatcag ctcaccacaa cctctgcctc
80041 ccaggttcaa gcgattctcc tgcctcagcc tcccgagtag ctgggattac aggcatgcac
80101 cactatgcct ggctattttt gtatttttta gtagaaatgg ggtttctcca tgttggtaag
80161 gctggtctcg acctcccgac ttcaggtgat ccgcccaccc cggcctccaa agtgctggaa
80221 ttgcaggcat gagttaccac gcccagctca attttttgta ttttttgtag agacggggtt
80281 taaccatgtt agccaggttg gtcttgatct cctgaccttg tgatccaccc gcgtcagcct
80341 cccaaagtgc tgggattaca ggcgtgagcc actgcacccg gactgagaat agtaattttt
80401 aattatttta tttttttgag tcggagtctt gctcttttgc ccaggctgga gtgcagtgcg
80461 cgatctcggc tcactgcaat gtctgcctcc cgggttcaag cgattcttct gcctcagcct
80521 cccaggtagc tgggattaca ggtgtgtgcc accatgcccg gctaattttt gtatttttaa
80581 tagagatggg gtttcaccac gttggccagg ctggtctcga tctcctgacc tcgtgatcca
80641 cctgcatcgg cctcccaaag tgctgggatt acagacatga gccaccgtgc ctggcctagt
80701 aattttttaa atgtctcaga acatccacca agtccaggct gtcctagaag gactggatcg
80761 gagtcagtgg aaggactggg ctttctggtt ctgctgttcc tgagggttct gatgcttgtt
80821 gctgcctgtg tgcttctgga cgttgggctg gcagggcagg atcagaggct gcatagcacc
80881 cttggtgggg atggggccaY ggtggggaga acttgagggt cagggacccc agtctccctt
80941 ctagtcatca atagtagaat catgcctcct tgcaggtgag acctttctgt gctccgtgtt
81001 ggtaacagga gccttgttct ttgtttctca gggcagttgg gtgagaagca gcttccatct
81061 tcaacctcgg atgatcgggt aaaagacgag ttcagtgacc tttctgaggg gtgagagaag
81121 agtgggttta aacagcctaa aatttctcct tcaaaaacca tcagtgacct ttctgagggg
81181 tgagagaaga gtgggtttaa acagcctaaa atttctcctt caaaaaccaa acagccatcg
81241 tagggtcggc tgcccatgcg ctggtaccaa actaagccat cacaggggcc ggctgtccgt
81301 gccctggttg ggacacgcct cctctcgagg tggcgggaga ggaggggctg gggagcttcc
81361 gaggcttctt gtctctgatt gatggtttcc tgggtgccag agagcactcc cagacctgag
81421 gcagctccag agggagcctg atagggtttc tgacccagag cagcctagaa atgagtttgt
81481 tgaaaccact ctggctgggt cctttgcttc tgctactgtt ttagggccat agttttgtgt
81541 tcgctccaga tgtttctgga gtagagaaac cccgacttta gcccttgact atgacactgt
81601 tgtggcttga agccgaggct ctgcgaggag gtgttgcagg aggacgggcc tcagaaggga
81661 cctcatcagt gtctgcaaac tccctgggcc acccctgcct ctgagccaag cgccattcag
81721 ggcagctgtg ccaggctggg gtttgcaccg tttccaccct ctcctgtaaa ccttggctgc
81781 aacacagatg cacctcatcc aaatgaggac accccagttt gggggccaat cccagtggga
81841 tgtgcagtga tgaaatcggg caggtgccag gaggcacctg gggtggctaa gactgtcctc
81901 aggaccacca ggacacaaaa ccgcagctga ggttatagca taaaggccac aaatcttttt
81961 tttttttttt ttttcctttt gtgaactttt ttttttagac cgagccttac tctgttgccc
82021 aggctggagt gcagtggtgt gacctcagct cactgcaaac tccacctccc gcgttcaagt
82081 gattctcccg cctcagcctc ccgagtagct gggattacag gcgcccgcca ccacacccag
82141 ctaagttttg tatttattta tttttttttt atttgagacg gagtctcgct gtgttgccca
82201 ggctggagtg cagtggcaca atctcggctc actgcaagct ctgcctcccg ggttcacgcc
82261 attctccggc ctcagcctct gagtcgctgg gactacaggc acccgccacc acgcccggct
82321 aattttttgt atttttagca gagacggggt ttcactttgt tagccgggat ggtcttgatc
82381 tcctgacctc gtgatccgcc cgcctctgcc tcccaaagtg ctgggattac aggtgttagc
82441 caccgcaccc ggccaatttt tgtattttta gtagagacgg ggtttcacgg tattggccag
82501 gctggtcttg aactcctgac ctcatgcgat ccacctacgt caccctccca aagtgctggg
82561 attacaggag ttagcctctg cacccagcca cttttgtgaa cttagaagtg actcatggca
82621 aacccatcag ttgcataggg ttcgcagtta tggggtgagg tggtcgattt ctcaaagtct
82681 gcttagcagg aagctacctt tgagcgcctc caccccttct gggccgctgt ggaaagggct
82741 gtttccaagt ccagtgtcct ggtgcccaga gcacatggct tgtggggatt gctggcttgt
82801 gagcctggct ggccctttgt gttcggaaac gggattggaa atttggggat tttagattta
82861 agacattttc agaagaactc aaatgtggga catgggggtc catttggtat ctttaggcag
82921 gaggtcgtgt tgggtctgtc actgcccagg cccagggctt tgctgaagat tctctcttaa
82981 ttcctagaga cgtcttgagt gaagatgaaa atgacaagaa gcaaaatgcc cagtcttcgg
83041 acgagtcctt tgagccttac ccagaaagga agtaagtggg cagcccgggg tctgctggag
83101 gcatccgttg ggcgacctag acacccgcct gtgctccagg gcctctcccc ggtgcccact
83161 cagttcactc tctcgtgtgc ggatctcccg agcccagtga aacgtggctt ccctcagtga
83221 gcgggaggcg ggggaggggc aggcgggcag gtgagaaggt gggtcctcct ggtgctttgg
83281 agctgggacc tggtctcggc actgtgaggc tgcctcagag tcccagcagt ggatggcagg
83341 tgtctctgtc gacagaaccc cgccttgctt gagaaggagg ctcttacgtc ccttctgccg
83401 gtcctgccct gggttcacac cccagtgtac ccccgaagcc cccaacccgt cgcttctgct
83461 ttgtgtgcgt ccccagaggc ccgaggaccc agctctgtca tcctcccagt tctgacccca
83521 tcactgatgt ccatggccag gcagccacgg tccacttccc tgttgaatga cttctgtgag
83581 cttgttttga ctttgttttt agggattttt attttctctc ttcagttaga acacaggccc
83641 tggtagtgag ggctggtttt cacttgtgct gttttctttg cagccctata cccagcagta
83701 cccagaacac tcccaggtag ttggtgactg acccagtccc tgtccttgag catttcacag
83761 cccagaacaa aggtccagag ggcaggtggc tctgagcacc accgtcagcc actagaaccc
83821 tgctgtgcag actgagaggt caacggcctt ttttcatgga agttctgatg ctgttaagtt
83881 ctgaaaagag aaacgggagc agtggaggag gccYggagag agatgcgaag cagagggcag
83941 gactgagcca gaggggctgc agcagcttca gcatgaacag aaaactggtc aggcccagaa
84001 aaggtgcccg ggggtcccta cccccaggct tgttcccagg agtcatggct gggagtgccg
84061 cctgaggctg ctgtacggaa gcccccactc cgtgaccctc Ygggttgagt ctgaatccca
84121 ggacacctga gaatgtgtct ctggcttgct gcccagaagg tctggggctg ctggtgtgag
84181 gagggctggg agctgggatg ggaggagcca ggcgagcctt ttccggatcg aggcagattc
84241 aggaggggag ggtcctctct gctgagcccc tgctgctgtg acagggacag cacactcaga
84301 ctgtgtcact agtccctctg ggaccccagg agtgcagaca aagacgtgct ttggaacaga
84361 gacacgggag atacgttttc agaggtctct aataaaaggg gtgacttcag tggaaaccgc
84421 tgcgcaggag gcaggactgg gtggtagcaa gcatggcctc ctgactgcgg cgagtaccag
84481 gggcacttgg ttccccagct gccaccgtga gacccccctg ggaacccaga agggcctctg
84541 cacagccccc ggcccgtgtg ctgcctccca gtcttgtcaa ccctgacctt ggagttctag
84601 cgggcgtgcc cgcctgtgtc ctcagctggg ggcgcatgag aagagacttc tgtgatgtgt
84661 taatgagggg tcagtggttc ccgccagagg ggaaggccag ggcctgcacc cccatgggga
84721 aagaactgac aggcagcagt gaggcctgag cccagcccac ccggtccgca aagattcccg
84781 tcccaaacac gagggcacag agactgcggg tgctctgaag cctcctgtgc tgaggaggtg
84841 agtggtcatt gtgggaaYgS catggccagc cactcacaaa caaggggcca cccaatccag
84901 gcaggcaggg caggtgaggg ggacatgtgg ctaggtcatg aaaaccagtt attagggaca
84961 gggagagaag gYgcagcctg tgcgaagtca acagttcttc tcagtgcgtt tttgtcttgt
85021 ttctgagatg gagtcttgct ctgttgccca gactggagtg cagtggcacg atcttggctc
85081 actgcaacct ccgcctcccg agttcaagtg attctcctgc ctcagcctcc tgagtagctg
85141 ggattacagg catgtgccac catacctggc taatttttgt atttttagta gagatgggat
85201 ttctcccacg ttggccacac tggtctcgaa ctcctgacct catgatccgc ccgcctcagc
85261 ctgccaaagt gctgggatta caggcgtgag ScaccgcgSc ggcctcaatg cactctttaa
85321 agagaagggc agttagcgac agggtctcat gttgttgcct aggctggggt gccctggcac
85381 gatcatggct gactgcagcc ctgtgcgctc aagtgagcct ctcacctcag cctcccaggg
85441 tgStgggact gccaacatga gccactggac tcggcagtgt aaactacttt tttcatgcta
85501 ttgcatatgt attgttcatt gataatatat agaaacataa ctgggttttg tgtatggatt
85561 ttgtgccctg caactttgct gaaataatta attagggttt tttgtatgtg gatctttagg
85621 gttttctacg tagaaggtcg tgtcatttgt gaatagggag aatttgtctt tgttttcttt
85681 ttcttgccca gttactctgg ctagggcctc cagtgctgcc ctgagagcag tggtgagaga
85741 atccgtatMt tgttcctgac cttggaggaa gagctttcag tccttcacag ttgagcgtgg
85801 tgtctgctgt gggtttcatg tagaggtttt atcgtggtga agaagttcct ttctgttctt
85861 Sagatatttc cttaactatt cttacctgga tccagaaagg aaccacaagt gcgtctctct
85921 ctttaagtct ccgatagacg cacactggaa gctgctgcat ttgctggtcc ctcagggact
85981 tgccagacca actaaaatgc acgaccccag acttttggag gacaaggtct cctgcccacc
86041 atggtcccag ccagcagctc caggaacaca ggctgggctc cctgcagtgg aggcggggtt
86101 gaggaatgct ggggtggcag ctactcaccg tgtgcttccc agggagcatc acctgttcct
86161 ctgaagccct gcctgggtgg cttgagcttg gaatcaagct gacccatttt gagagagtgg
86221 attctgagct ttttcctagc gtaaggtcgt tttgataaag gagtggtcct ttggacatcc
86281 ctgttctgcc gtcctgatac ctctagttgt gggttttatg tgtagcacag ggtgaagctt
86341 tagttctcag aacccacccc tgctgtaccc tgtgccctcg ccctccgctg tgtttgccct
86401 gaccctcctg taccctgcgt cctcgccctc tgctgtgctc acccgaccct gctgtaccct
86461 gcgccctcgt cctctgccgt ttgcccctga ccctgctgta ccatgccctc gccctctgct
86521 gtgttcaccc tgaccctgct gtaccctgcg ccctcaccct ctgctgtgtt cacctgaccc
86581 tgctgtgtcc tgcgcccttg ccctctgctg tgctcgccct gaccctgctg taccccgctg
86641 taccctgcgc cctcgccctc tgctgtgttc accccgaccc tgctgtaccc tgcgccctca
86701 tcctctgctg tgccctcccc ctctgctgtg ttcgccctga ccctgctgta ccctgcgccc
86761 tcgccctctg ctgtgtttgc cctgaccctg ctgtaccctg cgccctcgcc ctctgctgtg
86821 ttcacccctg accctgctgt gtcctgcgcc cttgccctct gctgtgctcg cccctgaggc
86881 ctcctgtcca gagttgctct ggctttggtg gcttcaggta gattctgagg gtcagtcagc
86941 acagaagcaa ctcagggaag cttcagaaaa gaccatttct caggttggag agacaaaaaa
87001 cattttgcaa atggagatca gaaaccattg aatttgggaa cctctttttt tcagagtctc
87061 tggtaagaag agtgaaagca aagaagccaa gaagtctgaa gaaccaagaa ttcggaagaa
87121 gccgggaccc aagcccggat ggaagaagaa gcttcgttgt gagaggtgat gcctgcaacg
87181 cgaggctcgc cctgcctgtc ggggccgggg ctccatgcat gctcttcatt gcagggagga
87241 gcttcccacc atctacaagt gtccttacca gggctgcacg gccgtgtacc gaggcgctga
87301 cggcatgaag gtgagcactg gctgtgcctg acccaggccc ggcagctgtc agtgtgaacc
87361 tgggggaggt agcaggtgtt tctgcagcct aactcagact tgYgcccaag gacactttga
87421 cctaggttaa ccgagacctg aagcagtcct agccagtgcc atccttgggg gtagatgtgR
87481 ggccagactt tcacttgaga caccccccgg ggggtctaga agtttcttgg agtgaagctg
87541 tgaaggagcc agtggtgtcg ctggaggagg agttggatct gccttccagg ggcctcagct
87601 gtcacctact gagggctcgt gccatgtggc ccgggtgcgg ctctgagggt ctctcaccga
87661 gtctctcctt cagaagcaca tcaaggagca ccacgaggag gtccgggagc ggccctgccc
87721 ccaccctggc tgcaacaagg ttttcatgat cgaccgctac ctgcagcgcc acgtgaagct
87781 catccacaca ggtacgccta tcgccagtgt cgcccacgcg ggtgacagcc aggggcacgt
87841 gacctgcttt ccagtcttcc tcatacccat ccccgcccca agagttgggg gtgcgtgaag
87901 gtggctcatg gggtctttgg tactcagtca cgttggtaga tgaaggctag agtagggcgt
87961 cagtgtgaat ctgcccttcc ctgtgatgga aggaattcct gacttcccca ggatctaggc
88021 agtttgtcaa aactaatagc caagcaatct tggtgtcctt ttgcaaattg gtcattttat
88081 tttttaattt ttttttgaga cggagtcctg ctctgttgcc caggctggag tgcagtggca
88141 ccatcttggc tcaccacaac ctctgcctcc caggttcaat caattctccc gcctcagcct
88201 cccaagtagc tgggattaca ggcacccgca accatgcctg gctaattttt gtaatttttg
88261 gtagagacgg ggtttcacca tgttggccag ggtgatctct aactcctgac ctcaagtgat
88321 ctcagccttc caaagtgcag agattacagg tgtgagcaSt gcacctggcc caaacaagtg
88381 tatcttaaaa ggcaaggcag aaggcatgaa ggcacaccag ctctggggag ctgcccacgt
88441 ggacaggcgg gaggcacgtg tggttctgcc tYttcacRtg tgtgtaggtc gtgtcattaa
88501 gaccggaggc ggatggggga attatgactg agggtgctgt ctctgtgccc gtcttatttt
88561 tcacaatttc tataatgcac aagttacttt tataatccaa caaggatatg ttttcaaaat
88621 gacaaacttg gccgggcgtg gtggctcaca cctgtaatcc cagcactttg ggaggctgag
88681 gtgggtggat cacctgaggt cagcagttca agaccagcct ggccaacatg gtaaaacctg
88741 gtctctacta aaaatacaaa aattatctgg gtgtggtggc acacgcctgt aggcacagct
88801 acttgggagg cggaggtgga ggttgcagtg agccgagatc acaccactgc actccagcct
88861 gggcaacagt gagacactgt ctcaaaaaaa aaacttgttt gaaccacgtg gacccacata
88921 tccatggtca gggactcgaa tccctggtat tcagagggct gccttttcct aagtgcaggt
88981 tctgtagggt ctttgcaggg ctaacttcgg gacttcagta tgagcagatt ttggtaaggg
89041 gtgggggggg gcctggaacc agctgaggac aactgtatat tgatccttac acacacagtt
89101 ttccttggtt ttgaacttat tacagaataa gaattattta ttcttacttg aatttactga
89161 agtatttttt cattaggatt gcttttcact gctgggtcat ctcccgacat gcgggttgtt
89221 attttttggg ttctccgaca tctctcctga tggcagcact tccttgggtt tggtccttca
89281 gactctgcat ctgtccggtc actgatggtc acaaccagca gttccttaaa aacctgaaat
89341 tgggccgggt gcagtggctc atgcctgtaa tcgcagcact ttggaggcta aggcagtagg
89401 attgcttgag gccaggattt tgacaccagc ctggRcaaca tagtgaggcc gtctttacca
89461 aaaacttttt ttttaattta ttgatggaaa cagtctcact cttatcacca tggctggagt
89521 gcagtggcgc gatcttggct cactgtaacc tccacctccc tagttcaagc aattctcctg
89581 tctcagcctc ctgagtagct gggattacag gcatctgcca ccacgccggg ggtgtttttt
89641 tttgtttgtt tgtttgtttt tttgactgag tcttgctctt gtcgcccagg ctggggtgca
89701 gtggcacaat ctcagctcac tgcaagctcc tcttcctggg gtaaagccat tctcctgcct
89761 cagcctccca aatagctggg actacaggtg ctggccacca cacccaacta atttttcgta
89821 ttttcagtac agacggggtt tcaccacgtt agtgaggctg gtctcaatct cctgaccttg
89881 tgatccacct gcctcggcct cccgaagtgc tgggattata agcgtgagcc atgacgcctg
89941 ggtaattttt ctatttttag tagagaggca ggttttgcta tgttggccag gctggtctcg
90001 agttcctgac ctcaggtgat ttgcctgcct tggcctccca aagtgctggg attacaggca
90061 tgagccaccg tgcccagccc ccaatttttt tttttttttc cgggacagtc tgtgtcgccc
90121 agcctggagt gcagctgtgc aatctcagct cactgcaacc tccacctcct gggttcatgc
90181 aattctgctg cctcagcctc ccgagtagct gggactacag gtgtgtgcca ccacacctgg
90241 ctaatttttg tatttttagt agagacaggg ttttaccata ttgattgggc tggggctggt
90301 cttgaactga ctKcatgatc cgcctgcctt ggccttccaa agtgctggga ttgagcactt
90361 tgtgtaagcc actgcaccgg ccccccaaat tttttaaatt acctgggtgt ggtggtgcac
90421 acctgtggtc ccagctactt gagaggttga ggcaggagga tcacttaagc ctgggagttc
90481 caggctatag tgagccatga ttgtaccatt gcacttcaac ctgggcaaca gagcaagacc
90541 ctgtctccaa aaaaaaaaaa aaaaaaagaa tcccttgaac ctgggaggtg gagtttccag
90601 tgagctgaga ttgggctgtt gcactccagc Stgggcaaca gagcaagact caagtctcaa
90661 aaaaaaagaa cagcgtagag taaaatgcca agatagggtt tcccttcgaa gagaaaagtc
90721 tgtcttgtga agcgtttcag ggcttgacag atgtggaggc agcacagggt gagtgggtct
90781 gcatgtccac atgtggcatt tgtggactag caagtgagat ctctttgttc aagggtgtga
90841 gaaagatttc cagagccagt acagcaatgc atacceccag accctgggta tggacccctc
90901 tcatatggag atgaattcta gagaacagcc atagctgtga caatcagtat tctatacaac
90961 cttagtgata cggcttcctt taagaatttg taggccaggc acggtggctc acacatgtaa
91021 tcccagcact ttgggagacc gaggcaggca gatcacaagg tcaggaattc aagaccagcc
91081 tggccaatat ggtgtaaacc ctgtctctac taaaaataca aaaatcagct gggcgtggtg
91141 gggggcgcct gtaatcccag ctacttggca ggctgaggca caagaatcgc ttgagcctgg
91201 gaggcgcagg ttgcagtgag ctgagatcac gccaccgcac tgcagcctgg gtaacagagc
91261 gaaactccat ctcaaaaaaa aaaaaagaca agaatctgtg gttaaggaaa tagctttctg
91321 aggtttcttt aaaaaccatc ctgaaatgca cacagctgat gaagccacgt gacagtgtat
91381 aaagcagttt aaagatctta ataaacgagg ccctcatagg ccccttgctt gggcccactg
91441 catggtgaac catgtgcaga aatgtcttcc cagctgtgat ggtttcacat tgtcatcgtc
91501 gtccccccgg gaggttggag catcaggggc ctggactcac tggactctcc cctctcagag
91561 gtgcggaact atatctgtga cgaatgtgga caaaccttca agcagcggaa gcaccttctc
91621 gtccaccaaa tgcgacattc gggagccaag cctttgcagt aagtgtgagt caggaccccc
91681 tcccagggct gtggccctcg caccttctta tctgcctctg tcccccaggt gtgaggtctg
91741 tgggttccag tgcaggcagc gggcatccct caagtaccac atgaccaaac acaaggctga
91801 gactgagctg gactttgcct gtgaccagtg tggccggcgg tttgagaagg cccacaacct
91861 caatgtacac atgtccatgg tgcacccgct gacacagacc caggacaagg ccctgcccct
91921 ggaggcggaa ccaccacctg ggccaccgag cccctctgtg accacagagg gccaggcggt
91981 gaagcccgaa cccacctgag gacggcagtg aggatgagca cctctagcag cctggactcc
92041 gcagtggctg tgtcagcctc acccttcgtg tgcacccgca tgggagggtc ggagggtgct
92101 gcccgccctt ggtgctggag gcgggcttgg tgtccggctc aagtagcctt cctctgctct
92161 gggaccagtg gtttattttc ccgcaaacgc tgagtgactY ggggccggac agttcataaa
92221 taattgattc ctttccccac taaagcagtc gaggagattt gtaatccact ttttagtgca
92281 acaagagctc catgttatgc ttgtaataaa ttatttacac gggagctggg ctggtgtgca
92341 gtggcaggtc ccgtcagaag agatgaggct cctgggacag gtcagcgtca ggggcagcct
92401 gctgtctgct ctggagggcg gcgctcacct ctgggtcgca gtccccacga tcagccagca
92461 gctgtgagag aggagcaggt cctcagccca tgccgcccac taggcctcag accacagggg
92521 aggggctctg gcagaaatag tcgagttgta ttgccagcca ggcaggcaca tggcccaggc
92581 agctgtcaat tctcatgtcc cccacRtggc ccaaggtggg catcttgacg ttacctctgc
92641 cacgtgtgag aagctctttt tcgggcaccg aggtattaac tgcagcagaa aaagacgagc
92701 ttttgttatc agttccacgg ggttgcccta gagagaaaac aggcaaactc acaggttaga
92761 agacatacag aaacagggct ggtgtgtccc ccatagtctg catgctgtgc cggaacattc
92821 tttggcagaa ggagcctccg gctgggggga gctcccctgg aggtgggact ggcccttgca
92881 cctgcctgac ccttgagctc caggctcctg ccagctggag gtgaaactgt gcttgtatcc
92941 ccagccacga agagctggac cagcttcaag tacatgtcca cagcaacatg caggaaggcc
93001 tcttccctga tggccgcgtc ttcatggaag taggagagaa gactagaggt aaagacatag
93061 tgacaaatgg ctacagactg ctggaaaggt agcaggtgat gccaagggat actgctcatc
93121 tgtggagcag aggcacagac aacccttccc atctggcggg acccagaggt gctgagatgg
93181 gggtctggga aacactgccc agccctgacc agccctgtgg gtggaggtac ctgtaaaaag
93241 cgaaaggcag cagcctggtg tgctgatccg gggccacacg gaggaggagc cgccccagcc
93301 tgaggtctgc aacaccaaga aRtggctcag gcaactctgg acatctctgc ctattatcag
93361 tgctggggac acccctgggg gtcgggacgt gtaccctggg aggcctggct gtggggatag
93421 tgtggggcga acagcctgag ctgaggatac ccaggtacct gtcagcagct gggagaggat
93481 gggggggtcg acctcttgca ggagggtggg tgtggtgcag agagaggcag tccccatgat
93541 aggcccattg gtcctggggt tgaccagtga gccagtaaat tatcttattg ctttaaacaa
93601 gtttgtgctt aatctgtccc aactaaaatg gagcttataa acttacttag caaggaacct
93661 caaggagggc tcgttcttaa ccatttgcaa gatgcctctg aaaagagcgg ccctccgcat
93721 ttgtgcctca gcagcgtgtt tcttaccact ctctgtcaac tgaaagagtg ccagccagga
93781 tatcttcctc ttctctaaac actcgaggat tgctgcacaa acgtggaaag cctttggcag
93841 gtctgtggtg ctctgtaaac cgcaggagac caaccctgag aatggccgac ctggtgctcc
93901 catgggtagg agggtacagc cctcagcaca gaagagggca tttcctcttt gcttattgta
93961 agtcttaaaa ctggtgacag ttttacctat agaaggtaat actgggcctc tggacagaag
94021 aggctcaggt aggaggccag ggacttcgag cacccacacc aaggctgctg caccacgtcc
94081 tcaaataaga cattaaaaga aaggcccaca ggccggatgc agtggctcat gcctgtaatc
94141 ccaacacttt gggaggccga ggtcggcgga tcactgaggc cagttcaaga ccagcctggc
94201 aatatggtga aaccccgtct ctactaaaaa tacaaaaatt agccgggtgt gacagactca
94261 cgcctgtaat cccagctact cgggaggctg atgcaggaga attgcttgaa cccaggaggc
94321 tgaggttgca gtgagctgag atcacaccac tgcactccag cctgggtgac agagtgagac
94381 ccccatctca aaaaaaaaaa aaaaaaaccc acggcctggg agttctcact cacacttccg
94441 caaacacaag gagctcctga gctagtctgg aaaccctgac ttggaagctg gctgcctggt
94501 gcccctgcct ggcccacagt gggagaggac accttggctg gtaaggtctg acttacattt
94561 gaggtcagat gtgacgacag caggcccatc aaggagaaga agaaaaggaa aaccaatagc
94621 tgtaaataaa aacgtgcact tattattaca ttaaaattac ctgtgctgtc attctaaata
94681 aggctgacac attcctcttt aattgaaatt ttttacatct aggccataaa tcctttaagt
94741 ggatcttaga aaactttcca atcacttcta gagagacagc ttaattgaga attaattact
94801 actggctggg tcatttcaca cttgccttta aacaaagcta gaaacagttt gaaaaagtga
94861 caagagccag aaagagaaga ctgctgcggt ctccttggct gtgcgcagtc ccaactcagc
94921 atcatctccc tgcaaggcct cctgtcagaa gtgtttgtaa aatccttgaa gataagccca
94981 caggctccag cctaaagtag ggcctgactg ggcagggtct ctgtggacac tcctcgctgc
95041 acactagggt cctaaggccc tggagccact aaaatccctt ctaacaaaac tacacaagaa
95101 acctgaagac gtactcagaa gaacccctgc agggtggtta taatcaccaa aaccctgggc
95161 gctgctgtcg atccagcttt gagctggtgt aagttgtgtg ctgacatggc acctatgcgt
95221 tgcggatctc gggctgggca cagagggctg ctgcctccag ctctcttgtg ggatgcttgt
95281 ttctgttcct gttctgcaca caccaccctt ggctccctgc acagagagct gtgtgggtgt
95341 cactggtctt gtgggggcag tcaggctttc cagggtgcag caaccaggtg ggcagtgggt
95401 ctgagtcgaa catggtccct ggcctggaat tcaagagcag cctctcccac tcctttccct
95461 atgcctatgg ctgcagacgg tcccatcctt gctgcctctt gtccccagca ccccaggtct
95521 gagctgtctc actgcaagct tatctggggc tgtccctcag cacatgaatc aaggctactg
95581 cagcatgaac acagaaggca ccacttgaag gctgacagca tttacgctgg gctgtgatga
95641 ggataaaaat aagctgaaga aacgcacttc aagcctgggc aacacagtga gacccccatc
95701 tcttttaatt tttactttaa acaaattttt tttttttgag acaagtctcg ctctgtcacc
95761 cagactgcag ggcagtggcg tgatcttggc tcactgcagc ctctgccccc tgggttcaag
95821 tgatcctcct gcctcagcct cctgagtagc tttacaggct atgggattgt aggtgcgcac
95881 caccacaccc gactaatttt tgtgttttta gtagagacag ggtttcacca tgttgcccaa
95941 gctggtctca aactcctgac accaagtgat ccgcctgcct cggcctccct aagtgttggg
96001 attacaggca tgagccacca tgcctggact acagaccccc atctcagaaa aaattacaaa
96061 attagccggg catggtggca cacacctgta gtctgagcta ctccagaggc tgaggtaaga
96121 ggatggcttg agcccagaag aggctgcagt gagctgactg caccactgca ctccagcctg
96181 ggcgacagtg agaccctgtc tcaactacat acaaccattt aaaaaactga aattattatt
96241 tttactagta aacttgatag tcaaagtctt actccaagcc agctgggcgt ggtggctcac
96301 gcctgtaatc ccagcacttt gggaggccaa ggcgggagga tcacggggtc aggagatcga
96361 gaccatcctg gctaacacag tgaaaccccg tctctactaa aaatacaaaa aaaaaaaaaa
96421 aaaaaaaaag tcttgctcca agccacatat ttgtctttag aaaaacagtt catcagacaa
96481 gcccagagaa atagcactga ttgaaaccaa gcttgcgaga aaataaatca gtaaaagaat
96541 ttcctatctt gcctcctctc tctcgcagtc cagcttcttt agctgcttcc tgatgttttc
96601 ttccctgact tgttgaatcg caaagtgcag tgcagcagct gagagccagt ccgggttggg
96661 tgcYggggag gcagcctcag gggagaggaa actgggacag agagaacggg gtcattgcag
96721 ggccttacaa ccatacaacc acgccataga aaccaagtcc ttattcccac ctgtcacctt
96781 tggggcctgc ctttccatca gaggacagag aagggtttca ggaccatcag aaactaggtc
96841 tgcatccccc aggtccacgt gagagtgtgg gcaggtgctg gtgctgcccc cacRgcatcc
96901 tggcgttctg agagctgctg actgagcagg cagctggcct ggtcctgtct accttgccct
96961 gtgctcttgg gccccagctg cctacatttt ggaagaagag gcctcatttt cctcagttgc
97021 ccatgcctgg ccctgtggat caggcattcc ctcctacaac agagaacaaa ggactgcctg
97081 gctctggccc cagtgtggtg tctgagtttt ctggctggtt aaaaaattgg taggaaatta
97141 atgaaacaat gctgtggttt aagagacttt aaataagctg ggcatgacgg ttcacatctg
97201 caatcatagc acttcaggag gatcgcttaa gcccagcagt ttgagatctg cctgggcaac
97261 acagtgagac tcaatctcaa ataaacaaaa acgaggcagg gcgtggtggt tcacgcctgt
97321 aatcccagca ctttgggagg ctgaggcagg cagatcacct gaggtcggga gttcgagacc
97381 agcctgacca acgtggagaa accctgtctc tactaaaaat acaaaattag ccaggcatgg
97441 tggctcacgc ctgtaatccc agctactcag gagactgagg caggaggatc gcttgaacct
97501 gggaggcgga ggtcatggtg agccgagatc gtgccatctc actctagggt gggtgacaag
97561 agtgaaactc tgtctcaaac aaaacaaaac aaaaaacaaa acttcagaca atctgatctg
97621 tgtttgtaga attagaactg gaggtgtgac ctgctttctc cttttttgag atggagtttc
97681 tctctcattg cccatgctgg actacaatgg catgatctcg gctcactgca acctccacct
97741 cctgggttca agcaattctc ctgcctcagc ctcctgagta gctgggacta caggcgcaca
97801 ctatcacacc cagctcattt ctgtattttc agtagagatt gtttcacatg ttggccaggc
97861 tggtctcaaa ctcctgacct caggtgatcc acctgccttg gcctcccaaa gtgctgggat
97921 tacaggtgtg cgccaccgcg ccggggccct cttctcttct ttcagcagac ggcgagcagc
97981 caaaccctga ggggacccgg tgtggcatca gtgattcaaa actagtcaca aagtaaggtg
98041 ttctccaagg aggcaggatg ggtactagca gtgccctctg acgacccctt aagaacacgg
98101 cacccacatt cagcaggtgg agtggctgtc agctctgtgg tcctcagaag ggtgtgtgag
98161 cctggattgc gccaggagct tgatggtttg caaggacccg tgaatatctg actggggtcg
98221 acaggtcagg gtaggctgag aatctgcatc cctgaggtcc ccatgacact gaccctacca
98281 gcacgcggtg cactctagga gcccacatta gatttaagag gaaggggagc aggtgcaaag
98341 gaatcactcg agctcctcac tcagacggga gcctgggaga ggccgttcct cactcagacg
98401 agacactggc agaggctgtt tttttttttg ttttttttct ggacagagtc ttgctctatt
98461 ggccgttgga gtgatctcgg ctcactggaa actccaccte ctgggttcaa ctgattctcc
98521 tgcctcggcc tccccagtag ttgggattac aggcgcccac caccacgaga actcggttct
98581 tttctccctg ctcacacgag aggctgccca caccgcttct ctcaagcaag ccagggtgtt
98641 taggagatga ccttgagcag gtcccgaagt gcatctgggc gggcacaccc catctcacca
98701 cccacacgta ctcgctggca aactgccggc cttcttgtag cttctgcagt tcccggggca
98761 gcgggctctg gcagtgtctc ctccaccggc agagcagcac aggctccagg ctcggccacc
98821 acacctatgg agagagcacc agcacacaga tgagggtggc tgagatggac acacctccgc
98881 tgccccagcc Rtgacaagcc cccagtgctc ctacaggcca ctacaggccc acactcgccc
98941 tgcgctctgg aactccaaag ccagtatttt ttacgtcaat taaggctcaa agcagttcca
99001 tgaggcaYtt attacccaca ctcatggaag acgtggaatt tggagaagga agagcctggc
99061 ctaacgcaac agtgaaggga ccacactccc ctgagctggg aacgaaacag tgaagggacc
99121 acagtcccct gagctgggaa tgaaacagtg aagggaccac actcctctga gctgggaaca
99181 aaacagtgaa gggaccacac tcctctgagc tgggaacaaa acagtgaagg gaccacactc
99241 ctctgagctg

Following is a FPGT genomic nucleotide sequence (SEQ ID NO: 5).

>1:74033451-74130850
1     gagatcttct atcaggctat cctggggaac tgctccaggc tgaaacaaac caccagttag
61    gacgaaccgc ctttgatgtg aaagctggga agctagaatg tagtttcgcc ttatccttag
121   cgggtcggtt ctaacaattt tgtcacccaa actgaaccac tcaccgggtc aactgggctg
181   caagccctta tgagttggag acaagKggcc cagccccaac acagtcagac aaatcgctgg
241   gcggccatct gctcctgaga ccgttgctag agaaacaaga caacatccaa gttctccaSa
301   tcatggtttt ccgggcgcca gccaaggcgc tccgggggcg tggttacgtg ggcgacgcac
361   ggagggggcg ggtcagaaac aaccgggcgg aggcgcaccc cagggcgcat gcgtgctgtg
421   cggcgcggtc tcagggaagg tggggctatg gcagctgcta gggaccctcc ggaagtatcg
481   ctgcgagaag ccacccagcg aaaattgcgg aggttttccg agctaagagg taccagagaa
541   ggcaccggag ttctcctggg caatgcagag ggagggtgct tttacgtgcc aggaggtttg
601   ctggactgtc acttcccgtt tacttctcat ctgYaggcct atgacgctcc ccaggagtag
661   ctagctaata atccttttga gttttttatt cttttcactg tccctgcttg acatgcttgt
721   tgcttacttt attcttagta gtatagatat taaaaatgag ggcggaggaa gaagaagaaa
781   atcttactag tgaagttatg cattgattag ctcattaata aaagttgctt taaataaatc
841   taaaagatac gaagcacagt attttgaact ttatgagtag atgccagccc cctatctact
901   tcacgcttta cattacgttc atctacttct gtaatgtaac cgtttgttga gggagtaaca
961   gaacatggag gaattatgga ttaaaaattN aaaggaagaa atttgttatc aaaaaattgg
1021  ctatgacact taatccctgt acacctgtct aataaaagtg attatatttg tgttgcagtg
1081  actgcttaaa aaatactggg actaattctt ggataacagt aaaactttca ggactattag
1141  attctagctg acaagttctg tttgttaact aattaaaatg ctaaatcatt ttgtttatca
1201  ataaagagat tccaactgtc tactaaaagt gcacactgtc ttttaaagat gtcatcagag
1261  agttgggacc ttctgttatc cagaatttta tgttatattc taacagccta tgtaagtttg
1321  catggttcat cttaaagtaa tagaaaataa agtacccaca tttataaaca gcaacattga
1381  gggaagggat ctttgggttg tgtctttctt agtcacctaa caccaagtgt ccStgataca
1441  taagaattga tttgcaaagc tggagatttg tttatgttta tctcctcttc ttattgaaga
1501  attgaggcaa tagtctttgg caagttaaaa gtcgctctct taatcaagaa acattatgtc
1561  attcagaatt tataattaaa ttggattgca aaccataaaa ggagggagtg atctaaaaga
1621  aaaaaaagga acttgtgaac agtcttcatt ataactattt tgaatcgtat taatgcacca
1681  ctaattattc cctaactttc aaaagccaaa gatacatttt ggaagatgat aatggatatt
1741  accttcttta tcatctttct caataggcaa acctgtggca actagaaaat tctgataatt
1801  tttgttttca tttccttgct ttttccaaat aggcaaactt gtagcacgtg gagaattctg
1861  ggacatagtt gcaataacag cggctgatga aaaacaggaa cttgcttaca accaacagct
1921  gtcagaaaag ctgaaaagaa aggagttacc ccttggagtt caatatcacg tttttgtRga
1981  tcctgctgga gccaaaattg gtacgcgctt tatggtcagt tttataatat aggtcctaag
2041  cagaataatc attgaagaaa aggtttctgt gacttacagt gtataagctg catatctcta
2101  cccacagctt tacaaacttt aaaatttgaa cataaattga ctttttttag aaagataaaa
2161  ggaatagcaa ctgttcttac ccattatgac ttaccttgaa aaacttccag aatgttactt
2221  aaaagaWaat tttattagtt ttaatgaaat tcacactatt cagataggaa tactcctttg
2281  gaccttatca gtagaaccct tgaggtcctc tccactccag agttcctcca gcaatttaca
2341  tgaagaaagc aattagtggg aaaaaatact cttgacctct tagggacata atgcagaatg
2401  caaaagaaca ctgtcacatg gcttaaatat aatacatata tttgaaaacc ctagtttagg
2461  tcaactttgc cctttgaccg tccattgcaa atagaaataa atgctgtttt tctgaatgct
2521  cttttctatg tgatacttaa agttgaagcc ccctgatacc agagataaga tatctgtata
2581  tgacattaat atgacattag cattattcta attagccaac attattttaa tccttacaac
2641  tatgaggtca gtactgttat tatttctttt tttttttttt tttttttttt tgagaaggag
2701  tcttgctctg ttgcccaggc tggagtgcag tggtgcgatc ttagctcact ccaagctccg
2761  cctcccaggt tcaggccatt ctcctgcctc agcctcccga gtagctggga ctacaggtga
2821  ctgccaccag cctggctaat tttgtttttg tattttttag tagagacggg gtttcaccat
2881  gttagccagg acggtctgta tctcctgacc tcgtgatcca cctgcctcgg cctcccaaag
2941  tgctgggatt acaggcgtga tattatttcc atagatgaga atctgaggta cYcaagagtt
3001  aagtaactgg cccaagataa ctagtgtggt agttatattt aagatttttt tttgggaatc
3061  caagttctaa aaatcttttt tcgaaaggaa ctctaacttg tgtttttgat tgtgtcattt
3121  gggagaatta tttaaatggg ctttgtgatt tgtaactctg tatgaatgtt tatatttatc
3181  agtcttctag tgttacagat tgtgtaattg attcttcttt cttataatta ctattttggg
3241  gagaatatta cctcatcatt tattactgag ggttgttgtc tgggtttcat tgctaattta
3301  ttgattggtt gtttgctatg agatgttttt aattttgttc tattgccaat acctttgatg
3361  tccatctatt tacttattcc tgaaaggcaa atccttaagg ttatataaca cctaaattta
3421  ctgtcatgac aaagttttag taggtttcta ttaaataaat tgtgcttttt taactttgtt
3481  tttaaggaaa tggaggatca acactttgtg cccttcaatg tttggaaaag ctatatggag
3541  ataaatggaa ttcttttacc atcttattaa ttcactctgg taatgttata ctttactaat
3601  ttacattttc tttttagtct tccaccttta atactttaga gacttttttc tttcttgcaa
3661  acactttcct tcttttttaa aagaatcttt gaagttattc tgctttgaaa acaaatattt
3721  tatgattttc atgacttttt ttaggttgta agtagtatag tgattttcac aaattttact
3781  cgtaaaattg tagatcacgt atatcgtcag tcttttatga atattgtttt gttttgggta
3841  tgtatataga aaattatttt cctaagacaa ctcattcaaa tatgaatagt tctcgggaat
3901  actttaatgg ggatttttct tttaatttta atttgtattt taagttccag ggtccatgtg
3961  caggtttgtt acataggtaa acgtgtgcca tggttggttg ctgcacctgt caacccatca
4021  cctaggtatt aagccagcat gcattagcta tttttcctaa cactctttct cccttaatgg
4081  ggattcttgc tttgagggaa gggtggttta acactgtcat tactagactt ttgccagtac
4141  tttttatctt gcatttttgt gtgattattg Rtagccagag gccacaatgc ttaaaaataa
4201  aaggaaaatg tgacaagata cagagtggac aagtaaatat ataaaagaga aatcacacac
4261  acaaaataag acattttaaa acagaaaagt aggaaggaca tggtctcaga atRaagaata
4321  gctttttaaa ttgaatacat ttagttgtgt gaaaattttg gttacatgaa aacctttgtt
4381  gtttttctat gtatgttaag gggctaatga aaactgtcat gaactgacac cagtccaggg
4441  acaggtattt tagaattatt catctacatg gcttccaagg cactttttca ttcttatgat
4501  ttacatacaa aacaatgatt ctttgtaaag atgatgtcaa agtaaagcat ccaagttctg
4561  gtttgaagcc taaaaatgtg taaaaMaatc taatttacaa ttttatttaa gaaaataatt
4621  attatcagtt tagtaaaaat taaattagat accaggaaat gcatagttag ataatttttt
4681  tatttttatt ttttggaaat agataattct tagtgctaaa cttgactatt ggctgctctt
4741  tgaaaaaaga aaaaaacaga aacttattag ctctcttttg ttgaacaatg tactgtgtgc
4801  tgccaagtgc tttacaggta ttattgatct tcagtaataa attaacctta gcttactata
4861  acatttttac tttataaact tcttaatttt tttgactctc ttgtaataac attcagctta
4921  aaacacaaac actgtacagc tgtacaaaaa tattttcttt atattgttag ggtttatttt
4981  gttgttttta tttttacttt ttaaatattt tggttagaaa tgaagacaca aacatattag
5041  cttaggccta cactgggtca ggatcatcag tatcactacc tctatagtcc tactaaagtt
5101  caggagctgt catctcctat gataacaatg ctgccttctg aaagacctcc tgaaggacct
5161  gcctgaggcc attttatgct taactttttt ttgtatgtat catatgaatt tattctaaaa
5221  taacaatgaa aagtatagta tagtaaatac ataaaccagt aaaatagtca tttattacca
5281  attattatat actatataca taattgtatg ttctgtagtt tagtaaactg gcagcacagc
5341  aggtttgttt ataccagcat caccacttga gtggtgcatc Rtgctaggac tttacaatgg
5401  ctccaacatc actaggtgat aggaattttt cagttccatt atgatcttat gggacaacct
5461  atgtatatgc tgtccataat tgagYgaaat gttgtaaaga agcaagtatt ttagcattag
5521  tatattagtt ttctataact tttattttct gtgaagtaga tttttttttt tttttgagat
5581  ggagtctggc tctgtcgccc aggctggagt gcagtggcac gatctccgct cactgctgca
5641  agcttcgcct cccgggttca cgccattttc ctgcctcagc ctccagagta gctgggacca
5701  caggcgcccg ccaccacgcc cagctaattt tttgtatttt tagtagagat ggggtttcac
5761  cgtgttagcc aggatggtct ggatctcctg aYctcgtgat ctgcctgcct cggcctccca
5821  aagtgttggt attacaggct tgagccaccg cgcctggcct tctgtgaagt agattcttaa
5881  ttagaagtct aaacatggtt gaaatttgtt gtttaaaatg tagatacagg ctgggtgtgg
5941  tggctcacgc ctgtaatccc agcactttgg gaggccgagt tgggtgaatc acctgaggtc
6001  aggagtttga gaccagcctg gccaacatgg tgaaacttcg tctctactaa aaatacaaaa
6061  attagccagg cgtggtggca ggtgcctgta atcccagcta ctcgggaggc tgaggcagga
6121  gaatcgcttg aacctgggac acggaggttg tggtgagcca agatcgcacg tcactgcact
6181  ccagcctggg tgacagtaag acttcatctc aaaaaaaaaa aaacaaatgt agatgcaaca
6241  tcatgttttg ggccgtggtc cttcttattt gttatacatg taattcaaaa catttcacag
6301  attctacagt atatttaaat tttttcctga cctacagttt ttaaaattgt cttatatcaa
6361  atggcaacaa gaaaatttct cttcgaattt ttaatYtgga tttcattatt ctttcctgat
6421  ttgcagtaac aagtggcata tattaaatat cgttaaaKat attttgattt gtaacttatg
6481  ggttataaaa ccctggggtt ttgaaaattt tataaataat actgcatttt taaatggtta
6541  tttcgtttta attttatagg tggctacagt caacgacttc caaatgcaag tgctctggga
6601  aaaattttca ctgctttacc tcttggtaac cccatttatc agatgctaga attaaaacta
6661  gccatgtaca ttgatttccc cttaaatatg aatcctggaa ttctggttac ctgtgcagat
6721  gatattgaac tttatagtat tggagaattt gagtttatta ggtttgacaa acctggcttt
6781  actgctttag ctcatccttc tagtttgacg ataggtacca cacatggagt atttgtctta
6841  gatccttttg atgatttaaa acatagagac cttgaataca ggtcttgcca tcgtttcctt
6901  cataagccca gcatagaaaa gatgtatcag tttaatgctg tgtgtagacc tggaaatttt
6961  tgtcaacagg actttgctgg gggtgacatt gccgatctta aattagactc tgactatgtc
7021  tacacagata gcctatttta tatggatcat aaatcagcaa aaatgttact tgctttttat
7081  gaaaaaatag gcacactgag ctgtgaaata gatgcctatg gtgactttct gcaggctttg
7141  ggacctggag caactgtgga gtacaccaga aacacatcaa atgtcattaa agaagagtca
7201  gagttggtag aaatgaggca gagaatattt catcttctta aaggaacatc actaaatgtt
7261  gttgttctta ataactccaa attttatcac attggaacaa ccgaagaata tttgttttac
7321  tttacctcag ataacagttt aaagtcagag ctcggcttac agtccataac ttttagtatc
7381  tttccagata taccagaatg ctctggcaaa acatcctgta tcattcaaag catactggat
7441  tcaagatgtt ctgtggcacc tggctcagtt gtggagtatt ccagattggg gcctgatgtt
7501  tcagttgggg aaaactgcat tattagtggt tcttacatcc taacaaaagc tgccctcccc
7561  gcacattctt ttgtatgttc cttaagctta aagatgaata gatgcttaaa gtatgcaact
7621  atggcatttg gagtgcaaga caacttgaaa aagagtgtga aaacattgtc agatataaag
7681  ttacttcaat tctttggagt ctgtttcctg tcatgcttag atgtttggaa tcttaaagtt
7741  acagaggaac tgttctctgg taacaagaca tgtctgagtt tgtggactgc acgcattttc
7801  ccagtttgtt cttctttgag tgactcagtt ataacatccc taaagatgtt aaatgctgtt
7861  aagaacaagt cagcattcag cctgaatagc tataagttgc tgtccattga agaaatgctt
7921  atctacaaag atgtagaaga tatgataact tacagggaac aaatttttct agaaatcagt
7981  ttaaaaagca gtttgatgta gagRtatttt aaatattgta cactttgcct ttttgagtaa
8041  cattccagag ataggtattt tttgtaggct gtttcactga actcagttaa tgaaaactgt
8101  attaacataa ttgttgtagc ataatattaa tagtgcaaaa gtacatataa gtcattttga
8161  tgaaaaatat tccaagacta agttgagaaa agagatacta ttttggatgt gtatcagtat
8221  ttttgttttt aataatgatt gatttgtgga gcattgtttt ttcacataat tagttttaaa
8281  ggtaattttc taagcatacc tttggaattt ttccatcttt tttgaggctt ttggtccagt
8341  gaagttctaa gtattcactg gcacttctct cctcaactgt aattctattt ttaataataa
8401  aaatggcata ctgtagggtc ttcagagtag tgtaggaata ctgtagaaat actttttcag
8461  aaacgaatcc atagctgaca aattcactca gtgcccaata tattgtgatt attttcgttg
8521  ataaagaact agatacaaag acctctgaaa ttgatgataa aatttgtatc tcattaattt
8581  tatcaaaatg aaactaaaag tacatatgta ttatacactt gaacatgtgt ttgtatatct
8641  ttaaaatttt cctttatgtt ccattccata ggaaaacaca catatgcaca caaaactcag
8701  ttatctgtgg ggaaagtggt agtaataatt gagattcatc aataatcata taatttcact
8761  atagacatta cttgcattat ctcctatcag tccttctaac aaaacttMaa ttaccagatg
8821  aactgacttt agttttcatc ttattttttg tccacatgct ggtgatgctg agaaacaata
8881  attggcccaa atgcagacat caagaagcag gcaggaaaat ggaaaaactg agataataca
8941  caggtgataa acagtttcRa gaaaataaaa attggctaga atctcaagtt atgtgtttct
9001  atattggtat aagcatataa gtgaaaagtc ttataagtgt aatagagaaa agatttgtca
9061  gtgtgttttt ttaaatgaaa taactagtct gtgctacttt atgtcaatat aaaaattggt
9121  aaacWagaag taacttgtcc acaaccctca gttatgatac ttatgtgcgt gttttttttt
9181  ccaaagtttt tcccaaggag aagatacaaa tatatggtag ctattgttta aaaatgattg
9241  atttacttgc agatttttca Raggatgtta tgtctttgtc attcattaaa tgttcaaaat
9301  tgtagtttta ccaaatctga agtgccatca gttataagaa tcaccattat tttatgttcc
9361  attaagaaaa acacaataaa acatgacact gctttttttg ttacttgaaa ttttcatatt
9421  tattggagag ctcttttaga tgtttttaaa tacagatttt tatttaaccc tcttgcatat
9481  acatataaaa taacaaaaaa ataaaatatt gagatatcat caagaaattt ctacagcttc
9541  acattcaaac tcttcagcac tttcagagct attgatatgc atatgtccac ctagtaccat
9601  cttctctgct ttcagaatta ttggtaaggc tgcatttcct gagtgctcta ccacacttat
9661  gtctggattt tttttaccca gctacagacc cacactcctg caagatttga tacccttcta
9721  tttggcaaaa ctcagtttca cttttctttc agtttaatca caggtcctta gaagatcgga
9781  cctgtgattc tattcaaagt cagaaagaga tttctcacaa attgaYgtca tattaacatg
9841  tcaatatgaa aattaattgt ttggtaaacc agaagtgacc tgtctgaagc cctcaattgt
9901  ggtatttgtg tgtttgtttt ttctttttca agattctttt taaagaaaat atatggtagc
9961  tgttgtttaa catttatcta cttacagagc gttcagagga tgttatatgt ttattaagtg
10021 ctcaatactg tattttaacc taatctgaat tttaatcata atcctgYaca atgcatggat
10081 tctggttgct ttgaaatggt tctgttcaaa ggacttatca atgtctcttg ctttgagatg
10141 tattgcttgg tgtgtagtag cacaaacgta ccaccaataa tgtacctaat tcaactgaag
10201 tgacagtcat atacgcagat atgaccaagt tcacatgtga gcaagtaaca actccatgac
10261 tRttgctgcc tggctaatag ctaYtatact atcatttgta aggcacattc tgttttctgg
10321 ggtgtcgaaa tgtggataaa aaaagatgaa ttaggaatga ttctaaccta agtatgtgtt
10381 ttaataaaag gatctaggca aaaaaaaaaa aagtaagtca ctcctaaatt taatccctga
10441 ataatgcagt gtacatgatg atagaggaga agtgtgtttt tgataagaag tgactaaatt
10501 ttgtgacaat cttaattttt taggcttttc atttagtctt ccaataaaga taattttttt
10561 ctgagtttta tcagcagtag aaaaataaga cctacatgga taagtttgaa attaaacatt
10621 ttgtctcatt ttataatttt tatttttatg aaatcatggc Rcttacatca tatactcagg
10681 tgtgtaaaag cctgctattt gtaactataa tccataaact tattgatgat ttaataacta
10741 tcaacaaggg catgggaaaa attcaacatt tgataataat cttttacctt aggcatttat
10801 tctctaagca aagcagaaat aaaggatatg tatcagtgta tactgattga aataaagctt
10861 taaaaatcca agtgatactc tgaaattgtc aaaagtttaa tggcatgaat ccaggattaa
10921 ttcccataac ctgtgatgat ctagtcatct tctgtagcta catagtactc ctaatgttaa
10981 gattaccaaa ttcagcaata aagccaaaat caaaactgcc ttctgtcaca tatagctgtt
11041 aagtaaacta cacaaaaKca gagttgctgt ttacatacat catgatgccg tctggacttg
11101 agcaccttgg cggctcagga ttaaggcacc tcagtctagc ctagcagagt tacaatggag
11161 agaagtgaaa actcattagt agctcaaaac aagctaaagg atttcagatg ctctttttct
11221 tgttcatcta aatcaagtct tcatctgtgt caagaactaa attgttaaag acctttttaa
11281 tttgcttagt gcaagaaaaa taatagcaac catatatcta gttaacttga gtcttctgtg
11341 cctctaaaat tttgtttaga gaaagcctat ttctattgag gttgaggaac acaattctaa
11401 tacttagtaa aattattaac attcattgca tttaactttg tcgtattttc cttcctccaa
11461 tactagtgtg ccaaattctg taacatagta gcatttttca tgctcccatt tatctgtata
11521 tacagaaact tctgcttagg ttttttttta tatataaaga aagtctagtc ataccagttt
11581 ggttgaagaa tactaattct gtccctggaa gagctgtcta cgtgagccac aacaaaccaa
11641 acttgccaca tcattcaaac ttgccaattt ggccgtagtt tagtagatga caactttggg
11701 tcaggttaat atttggggaa atggaataat aaaagctgct gattttccta ctgtattgct
11761 acttggagga ttggaggtgt agagggaaga tgcctgtaaa tgagtcactg ttatcaccta
11821 cctgcacatc agcttgattg ttgacactta tgtctaaaga tgttcatccc Ragagtatta
11881 ttgtgcatgc aagtaactga ttgatactaa cgagttaaca ttttattttg ggctgcttgg
11941 acaaaaagtc ttatcttttt gaagcctctg gctgcaggga tctcttagcc gttgcacata
12001 taaatttcaa ccattcacac agagcaattc atttctgatt gctgtagact agtgcaatcc
12061 atctgctagt gtcatttcct agctatctgt gccagaatta cactccttca attgtgcttc
12121 agtgcatttc tgaaacaatc taaactaaaa tgtctgtatt ctttggccac tggcttatga
12181 tgtgttactg atatgcttgt tgaatctcca gcctctttaa cactttttaa aatctttgtt
12241 acaaccaaca catcatagct aagtaatctg cacatgtaaa tgattttttt Waatttcttt
12301 tcttaccagt atccactgtt ttctctctgt agcacattca gatggttcaa gtgagtttta
12361 atttaccact tccttgtagg agagtgtcac atcgcccaga atagaattaa agcatttaca
12421 tcttgaggca aaaaaatctt ttaaaataca actatgtaga aatcaagtaa gtgttcattt
12481 catttgcagg tttagaaatg ttgcactgct taatgaagtt ttacgtgagt ggtttcttac
12541 ctattatttt tagccttggg gtttgagaaa gtaaattatg tccatcaatt ttctgtactt
12601 tagagaagtt tcaaatattt ctagaactag aaaacttggg actacacaaa gaaataatta
12661 tgattatatc aggtggccca agtgcagatt ttaaatgtac aggcacactg acaaagtcat
12721 aaattaaaaa tgcactaatt atatatcact gggatcaatc tttaatgaat tgaataagaa
12781 agatcactta tgactggtta aagttgatag agcttctaat taagcattat ccagtcaaat
12841 aaagagctgt gtatggaagc cagcctatga ggaaggaagg aaaaagtttt agagtaattc
12901 ttttttactt gttgcaacag ctgattcttc aatacaaaag aaatatttac tttgatttgc
12961 atttctctga tggccagtga tggtgagcat tttttcatgt ttttttggct gcataaatgt
13021 cttcttttga gaagtgtctg ttcatgtcct tcgcccactt tttgatgggg ttgtttgttt
13081 ttttcttgta aatttgtttg agttcattgt agattctgga tattagccct tcgtcagatg
13141 agtaggttgY gaaaattttc tcccattttg taggttgcct gttcactctg atggtagttt
13201 cttttgctgt gcagaagctc tttaattaga tcccatttgt caattttggc ttttgttgcc
13261 attgcttttg gtgttttaga catgaagtcc ttgcccatgc ctatgtcctg aatggtaatg
13321 cctaggtttt cttctagggt ttttatggtt ttaggtctag cgtttaagtc tttagtccat
13381 cttgaattaa tttttgtata aggtgtaagg aagggatcca gtttcagctt tctacatgtg
13441 gctagccagt tagaggatgt ggagaaatag gaacactttt acaccgttgg tgggactgta
13501 aactaattca accattgtgg aagtcagtgt ggcaattcct cagggatcta gaactagaaa
13561 taccatttga cccagccatc ccattactgg gtatataccc aaaggactat aaatcatgct
13621 gctataaaga cacatgcaca cgtacgttta ttggggctct attcacaata gcaaagactt
13681 ggaaccaacc caaatgtcca acaatgatag gctggattaa gaaaatgtgg cacatataca
13741 ccatggaata ctatgcagcc ataaaaaatg atgagttcac gtcctttgta gggacatgga
13801 tgaaattgga aatcatcatt ctcagtaaac tatcacaaga acaaaaaacc aaacactgca
13861 tattctcact cataggtggg aactgaacaa tgagaacaca tggacacagg aaggggaaca
13921 tcacactctg gggactgttg tggggtgggg ggagggggga gggttagcat taggagatat
13981 acctaatgct aaatgacgag ttaatgggta aagcacacca gcatggcaca tgtatacata
14041 tgtaactaac ctgcacgttg tgcacatgta ccctaaaact taaagtataa taataataaa
14101 ataaaaaaat taaatattta ccatgagttc agtgagaaga agcaatttac aaaattagcc
14161 atgtttctag tgtctttgag tatgtatctc taagactaca aacgtgctgg aattttccat
14221 aacataaaaa taaacaaaaa caaaaaacaa tacttctctt agccatatta tttcatcagg
14281 aatagtcagc ctagtttcat ctacaatgaa accgaagttt tactagccat catacccaac
14341 actgaattct agattcagat atgtacctcc ctgcttcgta tccctccctt actggaaaaa
14401 aatacatagg catctctatt tggagagctc taatcttcta tcaattaagg taatcttttt
14461 catctagata aatgacacag ccattcacca aattgctcaa ggaacaaacc aggaaatttt
14521 ccatgactct tcaggtactt cccctcatcc ttttcatcct gttttcaaca agtgaagtct
14581 atgtatgaaa aacacaacca aaatccatca acctctctca acttgttgag ctaccactgt
14641 tttctagact aatggaatag tttttttttt ttttttacat cccacaatgc cttattgtgt
14701 gcagtaataa caatgatMtg acttttataa ttgcacatga acgcaaagtt gcagaaagcc
14761 tgcaaaggaR agatttagaa gattggcatt ggggtgtatg aggcattgaa agaaaaagga
14821 atactgtggc catctcaacc ttacttcact aatttggtac tgtttttgta tcccattttg
14881 ctcccctgaa gactaccttt taggacaaag attcatacta ctttctaaca ttctacactt
14941 tattttctcc atgaagtttt gcctggtgat agtctgcaat ctctttacca cccacattgt
15001 tgttttttac ctttttcata tttgctatgt gtaatcagat gtcagctgga aatctgcttt
15061 ccctttagat gtaggcaaca ttagttgagc ctctattcta aaccccagag atgatgtcaa
15121 aaacttctct caaatatctg tgaaattcct gaagatcata tatctccata attgctttgg
15181 actgtaagct tccatttctg gtgagttagt tctgtttggg cttgcatgtg attttctcac
15241 aattctatga gctgagcgcc tatttttcac tatgtgagtc tcaaactttt cctctttcct
15301 gcaattaggg catcaccata tcctctccag aaaaaggcct tctcacacaa attttgtgtg
15361 tagcaaattt ctctgaatca ttggagctag ggaggaagRt gctggaagga aagagaagga
15421 tacatatcag agcacagcat taagtaataa ttgttcttag aaatcctttg gcatcttcat
15481 ctccaagact ttcttcacta gctatttttt ttataatcca aaattatgtc taactttttt
15541 tctcttcctc agaccaactt cttccatccc cttacgagat atgcacacgt tgtttacatt
15601 gtagacatat agcatttatc tcttctttct cttgtgtcat tagttttctt ccttcaatga
15661 attattctca tcagtacact aatattctgt gatttttcca gtttaaaaaa aaaaaaccct
15721 tcactacact tccttcaggt attactttat ttccttgttc cttttacact aaaattttta
15781 gaatacattg tctgtttttc cattcttcag ttcccgtctt cctatttact cttcaaccca
15841 attcaggctt ttagcacccc tctccattac cactactcca ttaaacttgt tctgaagatt
15901 tccagtgctc tcgactttgc taaatccagg ggtcattctt ggtctcatct tcttgccctt
15961 taaacagcat ttatctcaat tgattacttc tttgacttgc attctttacc tggatgcaag
16021 gaaccccaca ttactggttc tttttctaac tttctggtca cactttttaa gtctctttaa
16081 ctgatttctc ctcatcttcc tcacctcata tcactagaag gtcacagata tttgtRtttg
16141 aatttctcta tccacattca ctcctttgga ataccatcca ttttcatagc atctatgtgt
16201 tatcaattct caaatctgta tttctcatta tcaaaatgta actctcaaat tgttaaaata
16261 tgaatccata aattgtgaac atgggtcaga atttaatcag tgaggaagcc agcaggatta
16321 tgaagttgat ttttatattg ttccRgatgc tacaaggaag aaaatttata tacaacatta
16381 taaagaattt tttccaataa cagagtacat tttcttatga gataataggc ttaaaagaca
16441 atttagcaag agttttctca agaagttctt attttagata agaggtagga ttgaggcagg
16501 aaaatagggc ctggaggcag ggaacgtaag gccaattcac acttaagcta tgacaggaaa
16561 tatccttttc atagggtgta tgcagagtaa ataactttgt aactttactt cttcctctcc
16621 atttacatat ggcatacacc aagtaaccag tggaaatctc tagagggtat ttaaaccccc
16681 acaaattctg taacggtgtc cttgagcccc tatgctcagg cccaYtccca cactgtagag
16741 tgtactttca ttttgaataa agttcttcat tctttctttg ctttgtgtgt tttgtccagt
16801 tctttgttca aaatgccaag aacctggtca ctctccacca gtaacaggat tagataatga
16861 ctgtgggttg gatttcctga aaaccagaat ctgagatgta ctttagaatg caaaatattt
16921 ttaaggaggg cctgtgggat taatacttgt acaaggaagg ggagagagca aaacagagta
16981 gaagaaagtg aagctgagat gcaatcccaa agacagcctt aattggctaa tcccaagagg
17041 agctctggat attagaatag cacttcagtg tttcccaagt tgaacctgat tggccaggat
17101 ttataccaca catcaattat cttttctcag gtgcccaatt gataaggaag acaatggaca
17161 agatatctct ttaggaataa gccaatctgt gaaagggggc tgaccaatga aagctgtcta
17221 ctgacagcac ttgcagtagc tgaggtaaca agcccttcac tgaagaagca atatgggtgc
17281 catcacagtg tccaccacaa taacattata aagtccactc aattccaaga ttcaatttct
17341 atatgtaact attttaatga aacattgtta tgttttaatt caagttgaat tatgacttcc
17401 aaactaatca tgcaatattg tacatatttt aagtgtaccc aatccaagaa gaaactatac
17461 tttagtagat atgtcaatca ttgatttaca gaagcttttt ttttgtaata ctgtcacaaa
17521 tctacatgat aatccctagt gccagatttt acttttgact agctgaRcaa gctaaaatat
17581 tcataaattc acatgaagcc agatggcttc ccactgaata tgcatttgaa tgattcctgt
17641 acattattta ttccaagaag tgcacaaaat ataccatcgt catagtagag attcYtaata
17701 agtttgtttc aaaaaggagt caaggaataa caggtgtcca gtgctaacta tattttggac
17761 tgaaccatga ttctatgtat atttgagaat tactaacagc agattcaata tagttagttt
17821 ctattagtct ctgaaatatc aggaatctga aataaggaag gttcagcaag aatgactagc
17881 attttggaaa aaagaggatt taatgtggct agcataattt cttaataatt tgcttagttc
17941 tctaaaatat tcaaatgtac aacacaaagt attaaccatt tttgtcaagt ctatcagtat
18001 gtttttaggg gtactttttt caggttaaaa taacagatgt gaatttgaaa tgaaaatata
18061 acttaatcat taaaagcttt ttctccaaca tatttgggga gagaataaat gaaaatagta
18121 tttttttctt ttttaattca tagagttttc ctttcattta aatctgctgt gtcccttttt
18181 aaagtttcct gttctctgga catctgtcat cattgctgtc cccaccttcc atcttctgtt
18241 tttttccttc aaatgtggta atcaatgttg ttttgtaaaa caaatctaac aattctacta
18301 tctgaagtca ggatggatat gcttctgatc cttcttcagt gttttgttgc tatgctttca
18361 tgtgtatctg attgactttg tttgttggtc attgtcctta gcaaagtatt tgcagaggtt
18421 tcccatggcc taagatgaat ggactctcct gtRgaggctt tgcatttgct tctatcagga
18481 gaccagagaa gcattgccac ttaagagcaa cctcagatta agttcaagag tgagcttttc
18541 tgacttagaa ggctctgtat aaatccaaag tgaatatttt tgtagcaata attgctcagg
18601 aaccttattt tactttcttc tcttttttcc tttcttcttc tttttttaaa tttcttctgc
18661 tctgcttaac agcaaggcaa gctgcttgac aattctttgg tttgggataa aggaggacat
18721 atttacttct agctgatWct tatMcaaagg catatttttg ggaggcttta gattattagg
18781 gtgtcaaaga caccctctaa gaatttccga cctgaggaaa cacttggcta ccctctggtt
18841 ccttagaacc taagtttaaa tgtgtgcttt tggaaaattc ctcagggcag aaacttactc
18901 catacgacct acatttctta tacaaagaaa tatccactta tatctctgtg tttaagcatt
18961 ttcctgaaat ggtttgtgta tacaacttta tggtttttag ttcctcattg ttttttgcga
19021 ttatgacttt tatacttagc atttaaaatc agtccattat tctcacttat gtgaaacata
19081 actctagttc tgtattatct tattgactta ttatccaaca ttttcactag tgatatattt
19141 tagttagtag agggtatggt atgttagtgg gggggatagt actagtagat gatatatttt
19201 tataatgaat gttacagtca tggaatgtaa tgattatgaa aatgctaaac atatgaagaa
19261 aaaatgagga ataaagtaaa tatttatacc cttatccctt ttatccccca tcccataagc
19321 cacatgacgg agtagacagc tcagcaccta gcatgatgct gctatgagat gataaaccat
19381 gttaaatctt ttacagagca ggtcagaata aacataagca gacaaaagta tgttaaatgt
19441 atactttttg aaataggaaa taagcctaca aaatttgctt taaaaaagtt accatttata
19501 gtagatagaa cacatagacc agtgttagac cccctctgac ttcaaattat cacaatttga
19561 agttaattat gtgccaggat atttgatcag cactaagaat attttatccc ttgctctcag
19621 ggttcttcca gtttagttga ggataagata ggaaaaaaaa taattgcaat aattcctagg
19681 tagagctacc ataagtaagg catttgaata gtcagccaaa gagactaaca aaagctacat
19741 gatgaggaaa gatctcttag tttggtacgc gagagtgctc ggtgcataRc aaagtctgaa
19801 agaaacccag tcaaagtgta gtgtgtcact tcagaaatca catggaagtg taagagtggc
19861 ttgggaaaag gtctacactt gattaattta tagtatttta tataaatatg cagataattt
19921 catatttata taaatacaca ggtaccttag aaattaaacc tctgaccaaa ttatgattaa
19981 caatttattt caaagaagag gaaagaagag agaaagtcgt atgtgtttat gtgtgtgtat
20041 gtaatatggg agtgatattc ccagtatttg gctaccaaat gacaaaattg agtttagaca
20101 ttgatgaata gtaatgaata aggaaacaaa taataataat aattaatgtc ttcccacaga
20161 tcacttccta ataaaacact gtaaattaaa ggatatggta atttatgtga tagctttgct
20221 taacgataag cagcacttat tgaactgtgt agaactgaaa caaaagagaa ctggaaaaga
20281 gaaacttcac aaatgaatta acatagtaca aatattgtac agcagtttat ttactttgaa
20341 cctgaaaaaa tttaattaga tttcaaaacc ttataaaaac cttattttat Rttctcgtta
20401 aaacacatat ttcttggaaa tgattttgtt tagacatgag taggtacttt tgtctttaca
20461 aaagtttatc cttatctgtg ctgagctaaa aattcagtat acagctggtg ttttgattga
20521 tacagtatag aagtgacacc acatattatt atatcagtct gatttaaaga gctgaaagaa
20581 ggtgtttatg gagtaaacta cactgcataa actttttttt catggctctt agtagaaaaa
20641 taacaacagc aacgaccaaa atatgtacac aaatgcacat tttatatttc atagtcagac
20701 attaactaaa ccaataaaac aatcttcaaa gatttttatt gcataaaaac aaaatataac
20761 tttctagtta agcattaagc tcaacaaagg aaatgtataa aaatgaaaaa acattttagc
20821 tttgttccta gcactgctat taactcaccg tgatattcat taaaccaaaa gtcaaatata
20881 tgaacagcaa gggccactgg gcattgcaag tctgaaatgg tgtgctagaa agtgttttga
20941 aatttaaagg aaaagaaaaa aaaaaacctt cccgacaggt gaaaataagc ctcctattca
21001 gttatgatat ctaagaaaat ttaatggaat tattaaagga gcacttacag aatatgtgca
21061 attactttct ttagatggga caaatatatt tcataactga tttcttcatt tccaagaaca
21121 gttttatttc tttgatcttt ctttcatgat aatgaggtag atgtgtacag gattgaacat
21181 tacatttcaa atgtaatccc aacagacttg caacaagcaa attttttatg ttattcttta
21241 taaaatgata cctctgttta aaccactcac tttcttcaac atactatgaa ttcatatata
21301 atttgtgtat ttctcccact tacagaacac tggcttatac cactcttcag gtacttctct
21361 cctccaataa ttatattgtg tttttgtggg gttttttttt tttagctttt ctaagttctt
21421 ttggtttgat tacatgtttc tttttgtaac tctttttatc ttttctgttc atagtttcta
21481 ccattgctgc tactttatat aatttctctg tcatttgata tttatgactt tgcctaattt
21541 agcctcatca atttttagtc cccaaaaaaa atccaagatg aaatttaaat tactttggtc
21601 ccatcaattt tgtttaattt gtttactgtg taaaacaata atagagattt taatgaacat
21661 catcttaata agttttctag ttctctgatg tgatataatc taaattgtgt ccagactctt
21721 gattYatcat attttagata ttaaattgtt atttattttc ccactgtcta agatttttaa
21781 aaatctacaa gtagcaagac ttattgcaaa tcatgccaga ttcaaaaatc cttctgtact
21841 actagcccga ttaacccttt cttcctcttt catagcatgt ggaagttttt tttttttttt
21901 tttgatactc atcaaaagct actttgtaaa ataagttagt tagatttttg aatatcaaat
21961 taggttgtaa gctctgtaag caagggccct gccttatact tccttataga caagctgtgt
22021 caaaccactt tttggagttt tattttattt ctaattcaag gacctaacct cagcagattc
22081 tgatttagtt gatcacgagt aggttcttgt aattgtagtt tgtaaaatct ccctgaaagt
22141 ctggtttgta agttattgct agaacatcaa atcccttgta taaattacta atgctagcaa
22201 ctccaactaa tgcaaaaacc tcttaaggat tacatataca ggaagatgag gaaaacaaag
22261 agactaatat ttgtgtgaat tttccttgca tagaatttca aaagcctgta gtatttaggc
22321 tgcagaattg caatggccta ctctagtttc actttacctc ttttccgacc ttagcaatat
22381 tcctcttact gaaggaatgt attctaagca attcaattgg ttcagtccct ttcagttcag
22441 ttcaatttta ttcagttcaa ttcattccaa aacaattaaa tttatgtcta tacttataag
22501 gaactgtggt gggctatttc aaatgcaaag atgcctgcat tcaagttact tattgcctgg
22561 gaggagggat aaaagcatta attctatatt ctataataaa tcccttaata gaagcagatg
22621 ctgcatggat agcaacttag agtaggattt aaatgtgttt aatttcttgc ctattcttaa
22681 actacatata tgtattgtat atatgtatat atatttatgt aatgtataca ttgtattata
22741 tatagtatat atgcacacat ataaaattat agtataaact taccaaatat aaatatgttt
22801 agtcttcaaa atgaaatagt tactaacagc catcttcagt aacattaaag gatgcagccc
22861 tgatagatca tctcaaggtg actttgtaaa ttagtacatg tccagactct gtagaagaaa
22921 tgagttttat ataataagtc aaagagagaa tatatagtct ttaggggacc cgaacataac
22981 tattgtagtt cactaatagg ttaactgtta tatagctgca ccgagcatca tgggcaatga
23041 gagtttcaga aagataatga tggagttaat ttgtgaaaac tctcatgtga taatatgcat
23101 ttctctctcg ttctgatatg cttaaggcct acacattttc caaatgccgt gttacccttt
23161 accataggcc ctatcattta ttctctggct gtatatatga actagggaaa tatgggtgat
23221 aattttaggt aactatttgt gtactcagac ctagacctca acctgggaaa ctccggccag
23281 cagttaggaa atgataacac atggtgagcc aacttaaaca aatagactca agacttgtaa
23341 tcaaatccag tatattctat tatgatttaa taaaccYagg catcagaaac accacagtta
23401 gaattgtctt tgcatcattt gctttggacc tcaagagggg gtgaccttaa attataaagt
23461 tactggtacg ggaagaatga gacccccgga caacacRgag gtgcttctaa cacctttgca
23521 tgtacaattt ccttatgtaa ttcagaacat gcctcttagt attgatgaca atttcatttt
23581 taaagtttct agcttgagct taagtccatt aattcacaat ttttcttctc cattagtgtg
23641 aacttcatgt gaccaaatta tgggtttaag agacaaaaaa gggtatgaga tacaacggga
23701 gcagcaagga caacatggcc aaaatgttct gtgaagttgg taaagactcc tcagaacagc
23761 tgacattttg aagcaggaat atgactttcc tggagataaa ggcaagaata ctagagcaat
23821 cactctccat attaccagac aaggaagtac aatttaggct tactagtagc aagaactcct
23881 aaaaatggct ttctgtgaaa acaagtggtc ttgaaattca taataattat agtctactct
23941 tgataatcca tgttgaagaa ggggagtaca gttgtaagga aaacatgaag tttttcacaa
24001 attgtaatta aaatgtaaat ctttttgtat atacttagat actaaacttg aattctggtt
24061 gggaagggta tattatttgg atgccaataa aatgagatat aaatctatga ggacatatgt
24121 tgaattggaa gcactcaact tgggtttatt attaaaagtc tgcctggcat taaggatgca
24181 ctcaaatatt acttgctata acaagtccct aaataattgg cttcagagac aatagtctct
24241 gcaaaaagaa atcagaaatc tgtgtgacca tacaaactgc aactttctat taattcacca
24301 aatgaaatgt gttgatccac taatggggtt atgaatgaaa gctgagtttt tttttttttt
24361 tttaccccaa cagcattata ctaactccta gcactccttt aaattttatg caagatgtta
24421 aagattatat atgtggaatt tcaagtatga aaagagccag tctagctcca caactaaata
24481 tacaatgtat agaaacaaaa tacaattgaa tcagagttag ttcttattgg tggagtgctg
24541 agcttgccaa tacgatgaag gaagatcatg aacctttgcg tacacacaaa ttgctaatgc
24601 tatttctgcc actgttatag agaatggtga caagggggtt aaaaaacata gtacatgata
24661 actataatca ccattctggc attaagaaga tataggagaa gatgtaacaa aaataatggt
24721 aactacagac agagagctta ctgagacttt ctctgcttgg cgggaataag caaagaactg
24781 gtcctatgga atcactcatc atgctaactc aaagatctta cataaaccaa gaggcatggt
24841 gcttagatRa tgctcttctg tctcagggcc ttcaactttt tttttttgag acagggtttc
24901 gctcttgttg cccaggctgg agtgcaatgg cgcgatctcg gttcaggcat ggcatttccc
24961 ttaaagttga agaactacca ggaccgattt taattttaag tggccacagt gtagcagaca
25021 cagcagcttc ctgctttctc tatcactgga gtctgctgca gtaagcaaca gggaattagt
25081 cactgagtca acaaggggga accacccaaa cttgtttatt taattttgct acataatagc
25141 tacatatcta tggattctct aacaaccaca ttatatagtc ccacttttca aatctttaaa
25201 taatttgtcc tgcctatatc aaaatgtatt tcttttcact ttgaggaaca gccacaggta
25261 gataattgac aagtgaaaag aaaactctca aaaagaagag gaaagagtaa agaggacttg
25321 gtcatccatc ttcgatacca gctcagtcac ggtagaatat ggcaccagtc agagtcatga
25381 ggtgcccctt ctaggctcta gcttcaggac aacatttcta aacataccct gggccagaaa
25441 cgaacctgct gccctgaagg gaaggaccaa gttttggcag gacccatcac ctgctgacta
25501 aacagccttt gggccctgaa taaccagcag tgatacttag gttgtatgct gtgcactttg
25561 ggtgagactc tgagacttgc tggattcaga tgagactcag cacttttcca gctgtggtag
25621 ctacagggag agacaccttc tacttgagaa aagcagagag aaaataaagg ggactttgtc
25681 ttgcagctta ggtatcagct cagccacagt caggaagagc accaagctct taaggtccct
25741 aattccaggc cttggctctt ggacagcgtt ttgagacctg ccctgggcta gaggtgagac
25801 cattgccctg aaagttgagt cccgggccag gtggcattca ccacaagctg acttaacagc
25861 ccttgggtct taaaggaaca ttggcagtag tctggctgta ctcctcatgg gccagtgatg
25921 gtggtagtca ctgtgtgacg ttcctctgcc tatggaaagg ggagggaaga gtggaaaaga
25981 ctgtgtctca ttgtttgggt gccagctcag ccaaagtgca ataaaacacc aggtagactt
26041 ccaaggtttt gactttagta cctggctcca agatggcacc tctggacctg cacaggacct
26101 ggagaatctt gccatcctga aaagtaggac acaaacctga ttggctttcc cctcctcctg
26161 ctgattatag agcccagagc cttgagtgaa cataggcggt agccaggtag aggttatagt
26221 ggatcttgag tgagacccag tgtgaagccc cagtggtggt ggccacaggg atgcttgtgt
26281 catcccactt ccagtttcag tcagctcagg acagagagaa agattttgtt agtttgtgag
26341 aaagtaaggg aagagaacaa gagtctctgc ctaaaaattc agagaattat tccagatctt
26401 atccaagact atcaaggtaa tacctccaca agtctccaac agttatagca ttaataggct
26461 tggggtgccc ctgaatacag atgtggctta gacaacaaca cccaagtact ttggaatacc
26521 tggaaagtct tcccaagaag aacaaatacg aacaagccca gacagcaaag attacaataa
26581 acaccttact cttcaatgcc caaagatgaa tatccacaaa catcaaggct tttcgggaaa
26641 acatgatgtt gccaaatgaa ctaaataaga cacgagtgac caatcctgca gagacagaga
26701 tatttaattt ttcagagaat ttaaagtagc tgttttgagg aaactcaaag aaattcaaga
26761 taacacagag aactcagaat tcactcagag aaatttaaca aagagattga aataattttt
26821 taaaaatcaa gcagaaatta tggagtttag aaatgcaatt ggcatatatt gaagaatgca
26881 tgagagtctt aatagcagaa ctggtcaaac agaaaaaaga actaatgagc ttaaagacag
26941 gctatttgaa aatacacaga ggagacaaaa gaataaaaaa gaatgaagca tgcctacatg
27001 atctagaaaa tagcctcaaa aggaaaaatc tcggagttaa tggccttaaa gaggaggtag
27061 agaaggagct agatagtgat aaaatatcca aagggatcat aacagagaac ttcccaaatc
27121 tagagaaaca catcaatgtc caaatacaag aaatctatag aacaccaagc agatttaacc
27181 caaagaagac tacctcaagg catttaacaa tcaaacaccc aaagtcaagg ataaagaaaa
27241 aaatcctaaa agcagcaaga gaaaggaaac aaataacata taatggagct ccagtacatt
27301 ggctgaagac ttttcagtgg aaaccttaca ggtcaggaga gagtggcata atatatttaa
27361 agttctgaag aaaaaaaaac tgttaccgta gcatagtata tctggtgaaa atattcttca
27421 aacttgaagg agaaatactt tctcagacac actaaggctg aggaatttca tcaacaccag
27481 acctgtccta taataactgc taaaggaagt acttcaatcc gaaataaaag ggagttaacg
27541 agcagtaaga aatcatctga aagtacaaaa ctcactggta atagtaagta aaaacacaga
27601 atattataac actctaactg tggtatgtaa accactcaag tagaaagact aaaagacgag
27661 ccaatcaaaa ataactacaa caacaaattt ttaagacata gatagtacat taagatataa
27721 atggaaacaa caaaaaatta aaagtggggg cacaagttaa ggtgtagagt ttttatttgt
27781 tttctctatg cttatttgtt tatgcaaaga gtgttaagtt gttatcagct taaaataatg
27841 ggttataaga tagtatttgc aagcctcatg gtaacctcac atcaaaaaac atgtggtaga
27901 tacacaaaaa atagaaagca agaaaacaaa tcataccacc aaagaaaatc accttcactg
27961 aaagggaggc aggaaggaag atagggagag aaaatcacag aacaactaga aaataaatta
28021 aaaaatagca ggaactaagt ccctatttat caataataat attgaatgta aatgggataa
28081 actttcaaat taaaagacat agactggctg aatggatgga aaaaaagact caataatctg
28141 ttgcctacaa gaaacatact ttgtctataa agatacatat aggctgaaaa taaagggatg
28201 aaaaaagata ttctatgcca atggaaacca aaaaagagca tgagtagcta tacttatatc
28261 agaaaaaaat agatttcaat acaaaagcta aaaaaagagt caaagaagtc attacataat
28321 ggtatagggg tcaattcagc aagaggatat aacaattcta aatatatatg cacccaacac
28381 tggagcgctc aggtatataa aacaaacttt gttagaagta aagagagaga taggccctaa
28441 tacaataata gctggagact tcaacacccg acttttcagc actagataga tagtctagac
28501 aggaaatcaa caaagaaaca ttggactttg tctgcactat gcaccaaata gacgaaatag
28561 gtatttacag aacatttcgt caaatggctt tggaatacac attttttccc tcagcacttg
28621 ggtcattctc aaggacagat catatgttag gttacaaaac atgtcttgaa acattcacaa
28681 aaattgaaat aatatcaggg atcttctctg gccacaatgg aataaaacta gaaatcaaca
28741 tgagaaattc tggaaactgt acaaacacaa ggaaattaaa caatatgctc ctgaatattc
28801 agtgggtcaa tgtagaaatt aagaaggaaa ttgaaatatt tcttgaaaca aatgttagtg
28861 gaaacaaaat ataccaaaat ctttgggata cagcgaaagc agaacaagaa ggaagtttat
28921 agcgataagt gcctacatca gaaaagtaga aaaacttcaa atacacagcc taatgataca
28981 ccttaaagaa ctagagaagc aaaaccaagc caaacccaaa attaatagaa aagaaataat
29041 aaagactaga gcaagaaaaa tgaatttgaa ataaaatgtc aatgaaacaa aaagggtttt
29101 tcttgaaaag ataaacaaaa tgtacaaacc tttagccagg ctaagaaaaa aagagaaatg
29161 atctaaataa aaaatgaaaa aggaaacaat acaactgttg tcacagaaat tcagaggatc
29221 attattggct actatgagca actatatgcc aataaattgg aaaatataga agaagtgaat
29281 caatttcaag acacatacaa cctaccaaaa tttaaccatg aggaaatcca aaacctaaac
29341 agacgaataa caagtaaaga gaccaaagca ataataaaaa gcacctccca gcaaagaaaa
29401 gcctggactc aatggtttca ttgcttaatt ctaccaaaca ttttaaaaaa gaaataatac
29461 caatcctact ctaactgttt ggaataatgg aaaaggaagg aatacttcca aacttattcc
29521 atgaggctag tagtaccctg atactaaaac caaagacctg tcaaaaaatg aaaactatat
29581 gccagtatca ctgatgaata ttgatgcaaa aaccttcaat aaaatacgag caatccaaat
29641 tcaacaacac attgaaaagg tcaccatcat gaccaagtgg gatttatctt agggatgcaa
29701 gaatggttca acatatgcaa atcaattaat gtactacatt gtatcaacca aattaagtac
29761 gaaaatcaca tggacatttc aattggtgct gaaaaaccat ttgctaaaat tcaacatctt
29821 ttcatgataa aaatcataaa actggatatg gaagaaacat acttaaacac aataaaatcc
29881 atctatgaca aatccatagc tagtatcatt gtaaatgata ggctttcctc taagatgtgg
29941 aacacaagga tgcccatttt tcaccactgt tattcaacat agcactggaa ctcctagcta
30001 gagcaatcag agaagaggga aaaaaggact tcRaaattga aaagaagcaa gtcaaattat
30061 ccttatttac acatgatatg atcttatatt tggaaaaacc taaagactcc acaagaaaac
30121 gacttgaatt gataaattta gtaaagttgc aggatacaaa atgaacatac acaaaaatca
30181 gtagcatttc tctatgccaa cagcaaacaa tctgaaaaag aaatcaagaa attaatccct
30241 cttatagtag ctacaaataa aattaaatat ctaggaatta atgaaaaaat tgaaagacct
30301 ctacaataaa aactaaaaaa cattgatgaa ggaaattgaa gacacacaaa aatgaaaaaa
30361 ttgtccatgt ttgtgaattg aaaaaattaa tattgttaaa atgttcatac tacccaaagc
30421 aatctacaga ctcaatgcaa tccctatcaa aataccaatg acattattca gtgaaataga
30481 aaaaaaaatt taaaatttat atggaaccac aaaagaccca gagtagccaa agctatccta
30541 cgcaaaaaga acaaaactgg aggaatcaca ctacttgact ttaaattatt ctacagagct
30601 acagcatcca aaatggcatg atactggcat aaaaacagac acatagatga acggaacaga
30661 atagacaacc cagaggtaaa ttcatacatc tacaatgaac tcatttttga caaggatgcc
30721 aagcacatac attgggaaaa ggacagtgtc ttcaataaat ggtgctggga aaactcggta
30781 tctatatgca gaagaaagaa actagacctc tatctcttgc catatagaaa aattacatcc
30841 aaatggatta aagacttaac tacaagacct caaagtatga cactactaaa ataaaacatt
30901 ggggaaactc tccaggacat tgaactgggc aaagatttct caagtagtat cccatgagca
30961 caggcaacca aagcagaaat ggacagatgg gatcacatca agttaaagag ttgctgcata
31021 gaaaagaaac aatcaacaat gtgaagacaa cacacgaaat gggtgaaaat atttgcaaac
31081 tacccgtctg atagggattc attaatatcc agaattttat aaagagctca gacaagttta
31141 caggaaaaac atcaataatc ttatttaaaa atgtgcaaaa tatttgaaaa gatatttctc
31201 agaagaagac atacaaatga caaacaggca tatgaaaagg tgctcaacat catttataat
31261 caggaaaatg caaatcaata ctacaatgag atatcttctc acctcagtta aaatggctta
31321 tatcaaaaag gcaataacaa atgctggcaa gaatgtgcag aaaagggaat tcttgtacac
31381 tgttagtatg aatgaaaatg aatacaacca ctatggagaa cagcttgtag tttcctcaaa
31441 aaaataaaga ttgagctatc atataatcca gcaatcccac tgctgaatta catatacaaa
31501 agaaaagaaa taagtgtatc aaagagataa cttcactcct atgtttgtgg catcattgtt
31561 cacgatagct aagatttgaa agcaacctaa gtgtccatca atagatgaat ggataaagaa
31621 aatgtggtac ataaatgcaa tggagtacta ctcagccata aaaaagaatg agatactgta
31681 atttgcaaca acatagatgg tattggaaat cattatgtga agtgaaataa gccacacaca
31741 gaaagacaaa ttttgcatgt tctcatttat ttatgggagc taaaaataaa agcagttgaa
31801 ctcaaggaga tagagaatac aagagtggct accagaagct gggaagggta gcaggtggtg
31861 gggttgggga tggttaaggg gtacaaaaaa tagttcaaaa gaacgaataa gacctagtgt
31921 ttgttagcac aacagggtga ctacagtcaa aaataattta attatacatt tgaaaataac
31981 taaaagtttc taatttgatt gtttgcaaca aaacagataa atgcttgatg ggatggatac
32041 cctatttgcc ctgatgtgct tattacgcac tgtatgtctc tatcaatata tctcatgtgg
32101 cccttaaata tatatatatc tgctatatac ccacacaaat taaaattgaa aaattaaaaa
32161 aaagaaaata aaaattgaga aaagaaaaaa aaactctcaa ataagtagaa ctattatttt
32221 gttttccctc cccccaattt tttatgtttg tttattatac gatttagaaa cctctaatta
32281 gagaaacctc taatttttaa aacaaacaaa cataaagttg attacattag attctaaata
32341 acatttttaa aaatgttatt tgtccaaaac aataattagt tattaattga actataatta
32401 tcacacaata tcatttttaa gctggttaat taactcttag gatgggtgaa gaaagaatta
32461 agaaggaacg gaagtggcct gagtcatgaa gtttagatta ttctgattat tttaattcct
32521 caaagaaact ttttctgatt gaaatttagc ctttaataga tggactttct catgccaatc
32581 atgtatatct catcatagga caaatactgc attgcggtta cctgtttact catgcatctc
32641 tggccccatg agctctgtgg atttcttggt acaatacgta tttgttgaat ggataaatgg
32701 actgatcagt tcgtaaattg agctagactg acaattcaaa gaagtcatat aaatttggaa
32761 aagaaatttt agccagttac agaaatgtga ctcttacctc tatttaatct agattattta
32821 atcaacttta tttcatgttt acccaccaac aaaggaaatc acaggaaaaa ctatgatctt
32881 tgcatttgct gttatacttt attggacaca gaaatagcaa tattgtttat tcctttttaa
32941 aatatactct gacagttaaa gatactgaga acacatactt aaattactgt gacattatat
33001 tatcatatta taaatatata ttcattataa tgtattctca agtcttactc atttttgagg
33061 attaatctga atattacctc aacatgttca gactgatgat ggtgatttat acatcatcca
33121 acatactaaa aacttagata ttctagtgaa aaagaaagaa aattgtttga taaataagac
33181 tcttacaaat tatgcttgtt taaatgcaga aacacattat ttaaaagaaa attaatcaaa
33241 taattgtgtg cacttgaata gttgtatgca tcttaggcaa tggtcaattt atttttaaaa
33301 taattttatt tcaacacaaa ttatttaatc tttattaaaa ataaaggaaa aaaacctaaa
33361 tataaactaa ctagtaattc caccttctta tgtttaaagc aatgattaat ttgtcaacca
33421 gatgcaacgc attgaaactc tatgcttccc caaaacatgg aaatatatta ataaggacta
33481 atatacaatg aagaaattat caaagtataa attaattcaa cttctaaatg tgataataat
33541 tgttccaagt gcattagttt gatttcatgg gatacatttt cttttatcat ttctctgttg
33601 gaaccataaa ggtagaagtg tcaaggtcaa tttttacgtt tttcattttg aaagcatcct
33661 tttaaatctt tataaagaaa tcagtataaa ataaatataa atagcagatg cgtaagtgta
33721 gattgggata aataaatcgt ataaacccca aataaaataa tgcagaaaga acataagtgg
33781 gtttattgaa ggagtattag aatataacta tttgtatgca gaagtggtct gagaaatcag
33841 ttgaaaagac agaggcatta aaactagatt taggcaattc agtagaatat caaacttagt
33901 tgaaacaaag tagttgaaga aataatattt cataaatgtg ttctgacatt ttctaatgaa
33961 gaaacgagca agcataaaag aaagaaacct tactattaat catgtatttg agttggcttt
34021 tctttataaa ttattaaatt tccttgagta cttcaaatgc tctttttaag gaattattat
34081 tttttgcatc atttgtttta tatttttcca taatttttta aattaatatt ttgttagaat
34141 tgttttcagt ttacaaaaaa catggatcag aaagtacaga gttactatat actcccccta
34201 cacacacaca atttttctta ttaacatctt atatagtata tttgttaaca tgaatgaacc
34261 aatattgata aatgattttt aactaaagtc catagtttac gttagtgttg tgtagttcta
34321 tgatttttgc caaatggata atgtcatgta tccaccatta gagtatcata cagaatattt
34381 ctctactcta aagatttcct gtgcttcacc tactcatctc ttcctctcct ctacccctgt
34441 aaccactgat ctttttatgg tttgtatagt tttgcctttt ccaaaatgtc atatagttga
34501 aatcacacag gatgtagcct tatcagactg gcttatttca cttagtgata tacatttaaa
34561 gttcttccat gaattttcat ggctcctttc ttttcattgc tgaataatct tccatattct
34621 ggatatacca cagtttgtct ctccattcac ttatgaagga atatcttggt tggttcaatt
34681 tttgtgaatc acttttaaaa tacgagacta tacttgcata gccaaatcat gtattgcccc
34741 aggaattacc acaggataga actctttgat aatctgaagt aatctttctt ttgtttttat
34801 tctacttatc tcttttctct tgcatgaaat tcaaaggtaa aaaaatttct gttaagtagc
34861 atctcacttt aagcaacctt aaaatagtgc ttcttaaatg atgctccaag tagcatctac
34921 attagaatca tcagagttgc ttgttaaagt tcagattcct gggctctact cttgatgtac
34981 tgaatcagaa tttctgggga tggagcccag gtttctattt ttttaaacaa agctcctcat
35041 gttgcctacc ctcactaaac tttgaaagca gactactttt gtaatcaagt tgtgtttttg
35101 ataatgtatg atataacatg ctttctccac ttttggacgt ctcaggactg gggaaagtag
35161 gattcaactt agagtatgtg gccaactctt tattagaaag aagtactttt tacagaaatg
35221 tactgagtat tagggaaaat attttttgat tctatgttgt ttctttccaa cattctttgg
35281 aaaaggaatg caaggatatt atcctggacc atttacattt ccagcatttc ttcatcaggc
35341 tgaaggtacc cagaaaaaat tactctagta cctcaaacca ttacctagat ccacattctt
35401 aagaagggct tagagataaa tattgtttct ttcaaaccag gaaactgtta tagttcaata
35461 gtggttaata ttttgggtaa tattttgagt aattttctgc atttcttata ttgctatcgt
35521 ttcattttat ttccagcaaa atgtattgca ttagaatgtg ggagaattca actgagttgc
35581 tgaKtggatt ttcaaactca tcgcagaaat cacacctttg aaagccaaag ctttcatttg
35641 taaaacctag gctttttaag agaataaaag tattcttgaa aatcaaaagg aaaaattcta
35701 aaaagcagta catcagactt gtgtcccaag caggaaatta gaaacacagt ggaagatgat
35761 gtaagagcta atttttcctc catatgtgga aaacatacat gtacacacac acacacggat
35821 ggaagatccg agatattaga aataagaaaa gagatcaaga aaaatatatt tagttgtcct
35881 ctagaaggct cccatctttg tccttctgga ttcagagtat agaaaccatg attattttaa
35941 gaaactctga gaggagaaag agctggtgca ttatttccta aagtgtagcc ctgggagatt
36001 gcaagtcttt taaagaaagc tatccagtat ggtcttcaag ataaggaaga agagattaag
36061 caggaaggtc cctggacaaa acaaagactt tccaaactga gaaaatgggg gtcacagaag
36121 tgcttagaga aagctggtgg aactgaagat gtctggtttt caaacaagga gaatgtagag
36181 tgtatggacc aaggtaacca gatgccactg cagtatagca agtatcaaca gctgtggtag
36241 gcatgtactg ataagaaggg aaaaggagaa tatgtccaga tgaggacaaa aagtgtctat
36301 gaagccagac acctgatgcg ccaactatat ctcatcagtc tggaagcctt acctctgaaa
36361 cttctattac ttttgctgag caaaaatata tggtgaRtcc taactttgtc taatcattta
36421 ttcaaaaaga gagttgtttg aacatttaac tatagaaaat atgaaatctg tatctgttaa
36481 gttaaagcta tatcctctgg atgtgaatct gaagattaaa atttatactt tctaggtata
36541 agaagattat ctgaaataaa tatatagtga aaaatttaat gttttctttc tgggtttccc
36601 atttattctc catcatagac tgggttcttt atatcagtag aaataggcat acaatatgca
36661 tacaaagaga aatgtcctaa taaagtaaat ggaaggtgca tgaaagagaa attctggaag
36721 acaaatcaat aatatYtagc ttggatatta gagtcacatg gtcagaactg attccagact
36781 tccaacttac tagtaacttt gtgttttctc atccataatt tgtgaataat atctacctag
36841 cagcactgta tgtatgagat taaataatga gatatatgta aagcatgtaa actagggtct
36901 gacacatagc aaatgctcaa ttttcttatt cttaatctta ctgttcttgt catttattat
36961 tttacgaatt gctatttgta gaacttaatg ttttacattc tgatctatga ttcttatggt
37021 cggaataatc cacaatagta taaatcttgg tctatgttga gaatttcttc atacaaacat
37081 aattatgtag ctcttataca ggccaaacct gcattcattt ctattagtta tatgctagag
37141 gtaatgaatt tttattattt atttatgtat gtagacacat tctattacca ctctttacca
37201 actgccatta ttttggctta ggagaaaatg atcttgaaaa caggtctatg tagttttaac
37261 agctcttttg tgaacttcgg atgtaactga atcattttct agatttatct gttaaataaa
37321 tggtccatga aagtatgtat gggtagataa ttgatggaag caaataatcc tattgaaaca
37381 tttgctattt atttttgata cagttctttt aaacagactg attagttccc tttatgattt
37441 caccctcgaa agcacacacg attttgttct ttatcattgt tgcatgacat tccatttggc
37501 agttgggctt atttttagcc agactatcaa agtatttttc aactggactg tcactgcact
37561 tgaacttgga atcttataac ttgaagaact gYcctggaga aaggaagaaa cttataataa
37621 atgggaaatt ataaatctag accaacccaa acttgtactg gtaattattc taattattct
37681 tatttcctta agtgtaatat ggttcaatta tagttactga taactaacaa ctcattggaa
37741 tatgtgttaa tttgtatacg gaagataagg cagcatgttt tgtgaaagtc tttgaaaaac
37801 tatctgaact caaattattt ttttctgaag atctttatag gaaacaagaa atttcttaca
37861 aaaatattat tttagttcct tggtataatg ttacagaaaa aaatttggaa tattgctgaa
37921 tgtagggatt ttagaattat atcttaagta tctagtattt aaaaactaaa aaccgtcttg
37981 caactagaga ttgctataat taaaatgcaa taaaatcaaa tgaaataagt caaatatatt
38041 tttctatgta aatatattat ccaatatcga atgggttctt cattactaca attcaatatg
38101 attgcatttt aaatataaac atctgcattt taaacWcaca atcagtaatt taaattaagt
38161 attgtagaat ctagaataaa aaacagtttt gattacttgt atgttatgat ctgtgtctac
38221 attttgcaaa acacaactat gaatcaatct catttgttct tctttactag atgaatggaa
38281 gaaaaaagtc agtgaatcat atgttatcac aatagaaaga ttagaagatg acctgcagat
38341 caaggaaaaa gaactgacag aactaaggaa tatatttggg taaagttgta agagtcatta
38401 tttctttgta taagtgtctt cagtattcac cttaWttttt aaagtatctg tatatttttt
38461 aaacccgtag aacctcagac ataagcagtc atgttctaag ccttaggatg tcagattatc
38521 tctctttgac cactcatata gctctcaaaa tgcaaacata acatctcacc tccttaaaat
38581 ataaattgta atctgccatc attaaagttt aaaaataaaa acctaaaggc tagcctttga
38641 atgcaagcta ttgttgatct cagtaatctt ctcaggaatt agatcattct tgtaaaccat
38701 gccggcaatg aaaagcaaga tttttcttcc cacatagtgg tcgcatattg gccacattgt
38761 tctctttgaa ctatgacggt aagtccaatt ttaacaaacc ctctggtctc ttgacattga
38821 aaggctgtcc cttaatggaa ctgagtatca ttctgcccct gaacaatcat ataacaacat
38881 ataatattgc cttcaggatt tcagtagatt ttgttccatg ataacaagag aaaaataatc
38941 taagtgtcac aaccttggaa gacacaaaat gttcagaaaa gaggagcaag acccttatat
39001 acacaaaaag ccttctggtt aaattgaatc tgacattgag aaactagatg cccattagag
39061 ggtcaagaaa gttacctgcc tgactaagga aaagttccat ataggccaat tagccatgtt
39121 catttatagc tgtgttatgt aatgcactca tggcaaagaa ctccctctat tttacttaga
39181 aaacaagtgt aaagcaatga ccaaatgaca catctttaaa aYaaaatttt agatatagta
39241 aacatataaa tatcacataa ttggcaaatR aaatcaccca tgtataatat agtttatatg
39301 aaattcgtca atggatgtaa caaggctttc acaagtgttc aacttatggt tcaaaaagta
39361 gttggttctc tttatagttt ggcccaggat gatgaactca acactgacac ttgtgatgag
39421 ataccactga tctgactttt gcaagtagta tcacatgttg agatatggaa ctacatttga
39481 aattcctgta gaaatatgac tggcatgtta gtacagtaga attataaata tgtatttgtt
39541 ttgttggaaa agtatgaata tagaaattaa tcataaacat ctagctctta ttgacttaaa
39601 taaatatgct aaatgaaata tgattacatt gaagagattt tcctcaactt ttaaaggtca
39661 aagcctcagt tatttagtat tattttttaa tttagaaagt attgagcaca taggtgaagg
39721 ctagcttaaa ctagatgtat ccaaacctga atattaggat taacaatgga tttaaaatgt
39781 aggttctttc tgataccaca tcgacaacta caagctgttt tgacaactgc tataatggac
39841 ttttcctgtg tttctactaa atgcaacaaa tgtgaccttc ttttttctga ttagcattgg
39901 gggtgagatg caggaatctg tgtcagggag cttacagtcc agaatttgtt gagtgccagc
39961 tcgtattcaa gtgttgttct ggatacatca aatacaagac attatttaat ctatagtcat
40021 atgtagattg ttgtcatttc atgtgtgccg aataatatta actccggtgg atgataaact
40081 aaggattaga gacaaggcag tgggagttgt caagtcacat ggtcagtaaa ttctggaatg
40141 tgatttgtgt caaggtctgc ctgactccat agatagcgct cttcctacca taccctgctt
40201 acaaaaacaa gatttaggtc ctgatttatt cattgatttt tgSaatcatt gtagataaaa
40261 agcatagtta agtaaaggtg tgtaggcaag aatgaatgag taccatagaa agtttaggaa
40321 aagtgagaaa aaataatgtc ttcaccatat tatctgactt gagtaagaaa gctatgtgaa
40381 tcaatgtaag aattttggag tcatacaaac atggttttaa atacagcttc ttctatttat
40441 aagctgtata tccatggata tgttttttaa tctccttaat cctcattttc atctataaaa
40501 tgaggtgaat aataatcacc tcacaggata ttttcaaaat gaggtaaatt aaatactaag
40561 tacagggccc aacccatagt aagcattgag tagttggaaa tttctattat catgattgat
40621 tggataaata aggacagttt gaaggataga agacttatca taaagtgaga gtaacaaata
40681 gcttattaaa agttagaaag agtgaaagtt tttatgaaga ggatgatttc aaaattaaaa
40741 atgtaaagta ttagcacaat ttaggaagat gccgaaatct gaaatatagc ttttaatgat
40801 tttgattgaa agggatttga agaattttga gactagagta ttagaaggct aatcaaaatg
40861 gctatcaaat ttactgagga taatggtgag acatttttgg agagaaagac caatagcctg
40921 atgctgatga cattaaagaa gctacagaat gtgatgataa ggaagctgag gagaggatta
40981 tccagtcYag aatgatgttt ctgcaagaac taggggcctc ttatgttaat ggagatggag
41041 actgtagtac ttgctaaaat tttcgattcc atgactccac cctttatcat gtgaatcaga
41101 atctctggag atgtcttcca ataacctgaa tgtttaacaa gctccccaga taaaactatg
41161 cataataaaa atgatacttc taaagtttga aaactatact tctagaaaga tatccaaatt
41221 gcactgagaa ctctttgcct gaggtgatat tagtgaaggg atgaggaata tgggaacaga
41281 aagtaagcaa ctggtgtggt ctaaagagag tcaagagaat caaaaacaag caagcaaaaa
41341 cagaataatc tgcttttgtc tgatttcgtc aaggtagaga gcataatctg ggagaaaaaa
41401 gtgaattgct tccagggcag agttctaagg attttctttt ctttggaata aaatgatgga
41461 tgaaagaaag aaaagaatag tgtgctgaga atgtaaattg tcttactcac tcattcacaa
41521 aattttaaag gtagttggga agatcaaacc taacactgta tgaaatgaca tttaaatgag
41581 tatctagagc attataggtg ctaaataaat gttagaatct cattactcac ccttattcat
41641 ttgtcttata aagagcattc ctgtgataaa caattatgtt atgttgcctg acatcagcct
41701 ttctctaaac atttagatag caaggagact gtatacaatg cccaaaaagg aacatttaaa
41761 ctagcatgaa acgtaaagga tcactgatgt aaacagtttt tcatttgcta accaatttct
41821 ttatggcatt cccggtagat gctaatttca ttcattataa gagatttttc accacataat
41881 acaccattgc tctatcagct cgaatacaca atcttcctgg catagctttt acccacaaca
41941 taataaacag caatatagtg ctaaatgtaa gacagaaaga gctaaatagt tatcctgctt
42001 atgccaattt atagcagctt tggaatggga gcttgatgtg ggagagaggg gaaatggaaa
42061 tggaatgttc tttcatcttc tgctataaag ttgcattcac tcataacttt ggacatttgt
42121 ttaggtaatg gattggtgac aggaagaaat gaagaaaaag agaaggcagg aggagaaaga
42181 aagacagaaa gggcacctta gagtaccatt gtctgattat atcctcctct gtgctgcctc
42241 taatctttat caacataaca gcacttacta catggtgttg tttttatcca tttataggtc
42301 tatctcccca ctagtatatg tgttcattaa aggcagcttt ttttcttatt tagccttatt
42361 tatatttgta cttatttgta aaacaaacta ataacttagg gcttaccata tgccagaaat
42421 gcttctacgt atctttttgt gcatcagctt atataatcct aatggtgtat atgtaaagtg
42481 ctttagcaca gtgtctggca catggcaaac cctcaaaaat gttagttaac acttaatcat
42541 tattgtttat gttaacaacc ctctgaagta agtgttgcaa ttgccatgtt atacctggag
42601 aaaatgaggc taatcaaatt aaactggctt gaactagatt aaacaatttg tatgatttac
42661 ctaggattgc atccatcttt atttgatttc aaaatgtatc atattcataa tcttggttat
42721 gaatattata caaccttttt gaaaaaacta tggaagtgat ggctctccac atgtgacttc
42781 aaatgttttc aattaaatta ttttgtttca atagttttta tcataataaa ttttaagact
42841 atgttttgct aatttcattg tcaagccaaa tttgtatctg cttaatctat aatatgaaat
42901 ttaaaaccat gagaatactc cagaaaagtt ataatttttc tttttctttt tctttttttt
42961 tttattatac tttaagtttt agggtacatg tgcacaacat gcaggttagt tacatatgta
43021 tacatgtgcc atgttggtgt gctgcaccca ttaactcgtc atttaacatt aggtatatct
43081 cctaatgcta tccctccccc tccccacacc ccacaacagg cccccgtgtg tgatgttccc
43141 cttcctgtgt ccatgtactc aattcccacc tgtgagtgag gacatgcggt gtttggtttt
43201 ttgtccttgc aatagtttgc tgagaatgat ggtttccagc ttcaaccatg tccctacaaa
43261 ggacatgaag tcatcatttt ttatggctgc atagtattcc atggtgtata tgtgccacat
43321 tttcttaatc cagtctatca ttgttggaca tttgggttgg tgcttagttc caagtctttg
43381 ctattgtgaa tagtgctgca ataaacatac atgtgcatgt gactttatag cagcatgttt
43441 tataatcctt tgggtatata cccagtaatg ggatggctga gtcaaatggt atttctagtt
43501 ctagatccct gaggaatcat cacactgact tccacaatgg ttgaactagt ttacagtccc
43561 accaatggtg taaaagtgtt cctatttctt cacatcctct ccagcacctg ttgtttcctg
43621 actttttaat gactgccatt ctaactggtg tgagatggta tctcattgtg gttttgattt
43681 gcatttctct gatggccagt gatgatgagc attttttcat gtgtcttttg gctgcataaa
43741 tgtcttcttt tgagaagtat ctgttcatat cctttgccca cttgttgatg gggttgtttt
43801 tttcttgtaa atttgtttga gttcattgta gattctagat attagccctt tgtcagatga
43861 gtagattgca aaaattttct cccattctgt aggttgcctg ttcactctga tggtagtttg
43921 ttttgctgtg cagaagctct ttagtttaat tagatcccat ttgtcaattt tggcttttgt
43981 tgccattgct tttggtgttt tagacatgaa gttcttttcc tttttttttt ttttttcaga
44041 cggagtctcg ctctgtcgcc caggYtggag tgcagtggYg cgatctaggc tcactgcaag
44101 ctccgcctcc tggattcacg ccattctcct gcctcagcct cccaagtagc tgggactaca
44161 ggcacccacc accacacctg gctaattttt tgtattttta gtagagacgg ggtttcactg
44221 tgttagccag gatggtctcg atctcctgac ctcgtgatct gcccaccttg gcctcccaaa
44281 gtgctgggat tacaagcatg agccaccgcg cctgacccag aaaagttgta atttttaaac
44341 actatgacat caacataatc caaaacaact tttttggcat tgagtagata catcttggtc
44401 agtaattaca gtgcctcact ttaaaattga ctaggtttaa ttatgtacaa aaaagtggtc
44461 aaaagaatgc tctgttccat taaatagtca caatgtatag aggaaataaa aaaatgtttt
44521 ctgagataca cctttttgta ccttttctct ctgaaaagtt catctgaggc ctgttgcatt
44581 ccactatact catccttaaa acaaaatatc ttctaaaatt attgcactat agccaactat
44641 gaaatttggc tattataaga tgaatagcac tggaaacttt tcaagctgat cttatttaag
44701 aggagtagac cctttctgtc aaactactaa gtaggatatt gaaggggaaa tgtcatctta
44761 taattaacat agaatgaaaa tattatttgg catgtttggt agtgtgtttt gccaattagc
44821 cacaaaacaa aaaataagaa tcgtcaacaa caaaaaaaac cctcaaatcc aaaaggaaac
44881 aaagaattca taatgcccta agtcagtcta tttctctaat tcttttcttg tttgtccagg
44941 taaaactagt taagaaccat aattttacag gaatatcttg tgaaatcatt gagaagcaac
45001 ttgacctcaa tctctctctg cctctctctc tctatctctc cctattgttc tccctctcct
45061 tctccatctg tagctcgcta tctttctatc attttctctc ccccttaccc ttcatctctt
45121 cttcttttcc atcctgtacc tccatgattc cttctttcct atccctgttt tgaagagcaa
45181 aacaatacaa aaacagtaaa aataatatca atgccttaat agaaataact attatagcag
45241 ctaatattta taaaagcttt acaagctcta acttatttac acttcacaac aatcttataa
45301 gataacaata attatgccaa ttttatcata tctgtcactc taactataat tgtttattgt
45361 atgaatggct gaataaatga atatacttca cagtattagt ttgcagattt tatttgcaag
45421 atatcaaaca aatatatttc tggatatttc ttggagatat atattagaaa cagatcttat
45481 tgatatagtc tgcttctatt gtttggaggg catggggcag ggaagaatct gcaatgaata
45541 ggcaagaagt tgcaactagc catttgaaac ttaaatgatc aatttgggaa actagacaac
45601 ccataaaaaa tccttacctt ctttctacat tcttggcttt tccctaagtt ttaaccaatg
45661 aattagcttt aaaatatatc tacctgtctg aataccttgg agagcagtgt gttacttttt
45721 ggccaactgt tcaaatgtta cattttaata agttcccact tgtggtcatg ttagatatct
45781 tcttgaaagg atgaggtcat gaaaaagaag tttaattgga tcacaaaact gcacactttt
45841 ctaggtMaaa ggtaaaggct aggaaaagaa ttcattatgc tacaagaaag aaagtaacct
45901 ttgggtacag aactatcatt tttaatgatt aagaacagca tttactatta gaaatatatt
45961 cataatagtg gctttatttt aattaggaac ttcattcatg ccccagcatg cactatgaac
46021 tctttaggat atgttaagtt acagtgtggc atggcaggtg atgaaaaatg taaggggaaa
46081 ttaaaaaata aattgagctt agggtattag aatacataag tgatgctcaa ttggcagtga
46141 atttgacata cacagttact ttagaagagg caaaagaaga gaaaatggaa tttctStcct
46201 aggaatgatt gcttaaatat cttgaatatt ttaattacat gtttcaaaac agaaacgttt
46261 gactagaagt taatgggaag tgagaattag gattcaaata tagcccccaa agtaactctc
46321 attttaaaaa tgtacattcc agttattaaa gttgagctaa aaattgtact attaaaaatc
46381 acacttgact gccaaatatt ataggagtct attctctgtt gattcatttt gttgacatta
46441 agagaagctg catgagttca aggaggatat aattcaagag gagaacaaaa gcaacaagca
46501 gcggctcagt ttaaagcaag gaactcttta ggactctata ctgagtcact tatagatggt
46561 aaagtctagt tcaagattca gttagctgag gaacaattgt tgaataaaga gtcattaatt
46621 ttgctttcaa ttttatttat gtaaatgata aacattcatc tagtgccttt cttttttaaa
46681 aataaagcaa tggaccctgg catcttgtat tttctgttta ttccatgttc atttgttttg
46741 caaagctgat cagagtatta gatatcagga cgaacacagc agtcaatttc aggattttat
46801 ctagtatgtg tatttccagg actgatgcat tcaaaggatc cgggatttag tgagtagttt
46861 atatcaagga gactcttgaa aacaacctga agtgagcctt aagagcagaa gtgaggcgta
46921 tagtaggtgt ttagYaggtg ttgtgccaga cttattgaat ggatcatcaa atttagatca
46981 cagaataaga aagcaattga gtttaccctc tcaaataaag tgattttcat ctcaacttta
47041 actttttacc ctcctttgca tttttcattc tttgagtctc tccactgttg aaaatgtagt
47101 aatattaaaa gttYgagaga tcaagtttaa ataagagaat ctcatgtgca gttctgtgtt
47161 ctatgtataa tttaaacttt tcagagcacc atgatgaata aaaattatgt atacatagaa
47221 aacagacatc tgaaagtaaa ctcatttcac tcacacacaa aatctcacat aatatctacg
47281 gagaaattca ggaaaatcct tccaaaaaga aaggtggggg gaagtagcat ctgataagat
47341 attggaaaaa agaatataat cccaatgtat tacaacttct gcctgaagca aagttctctt
47401 gtactctgac tgggtcagat ttcacagata aaggtctaaa ctctggtagg gtactctgat
47461 atagtccctg gtgagaagtg gagtgattct attaatgaaa tccttgtctt tgtctgaaca
47521 aagaccattg ccccaggagg gcccttgaga gccacaggta gcctttcaaa aggaatgtaa
47581 agctaaaatt ctcgacctct tgaggtccac ggtgctccca ggacattttt cagtagaaat
47641 gagatcatat ccttggcttc acaggtcaat ttcaagctgc ctcctgccta tttaaatctc
47701 tagcagcttt agagagatag catagtattt ggtgagtgag ccaaagtttc atatcacttg
47761 taaagtactt acacttgaaa ggtactataa attcagaaca ttatcatcaa ggcatccagt
47821 taagaacatc aaaagctatt ggaattttaa aatagaaaaa gaaaaagtgc tattctccag
47881 ggtactgcta aaaagagaaa ggctctaaat ccagggtcat tgaagaacct cagtgaaatg
47941 ctttaattag aaatggcaag ccttgtggtt tattttcaca gccatgggaa tgcagtattc
48001 ccaaactttt tttaccctcc tacccttctt gctttctgtg ttcccctgca gcaaaacaca
48061 tagacatgct tactaatact gggaaacaca cctcaacttg ctttggaaag ccttttgtgg
48121 aagtacaata aactccagtg tttataaatg ttaataatat aagaaggggg ttcagaattt
48181 catgaagata gttaagaatt taactcactt ctatcagcaa tttccctcag ctcaaaaaat
48241 actgcaatca aaatcatttc tgatgaaaat gccactgttt taaatgtcta cttataataa
48301 aatgagccta cttataaatg atagagctat ttatggtatg gcagtaactt cacaaaataa
48361 catgattctt agaaatgtgt ggtctttggc ccagcctggc ttttaaaccc tcaaagccaa
48421 atatattatg gatgtcttgg aagaaagtaa actaggtact tggaacacac ttggaaatgc
48481 aatcacaggt cacagaggtc ttctttgtgg ttatgacttc aaatagtaga ggtattcagc
48541 ggagctgaac tctgcctttc aagctaggta gattggattt ttctcttaaa gtttgtaggg
48601 aatcagtgtc cataaataaa aagggaatga aaactgtgac tggaaactga gaatgttgat
48661 ggacaRtgat tcagctctga gctgcttcgg cttttcttcc ctggtctttc tattgtccag
48721 caaatgaaac acactataaa accacaagaa aaaaaaacaa agtattggac tgggggagga
48781 gagagaggcc ttgtgatcct aagaaaaact atgtaaccag cagcctaagc aaaacaggga
48841 aggatgcaca ttcttctgag ctaatcataa tgaacttaat ggcaaatact gaaagaagaa
48901 aaagctttgg agctcttctg tagcaataaa cacctgagaa aatgcagttt ttcaatatgt
48961 atgtccaata ttgtatagca atacctgtta tgttttgctg ttttcaaagt ggaaaaaatc
49021 atttcatcag tgtggtaatc cttgaaagcc tcattcttat agttatacca ggattcaaat
49081 cctatcatga ctctgccttt taagtagttt gttctttttt tccaacttgg gcaagttatt
49141 taacctattt aagcttcaat ttcttcaatt ataaaatgag taaaataata tatgtgacaa
49201 tatgcatgac tttgtcctgt tgtgtccgga attggtgggt tcttggtctc actgacttca
49261 agaatgaagc cgcggaccct cgcagtgagt gttcagttct taaagatggt gtgtccgggg
49321 tttgttcctt ctgatgtttg gacgtgttcc gagtttcttc cttctggtgg gtttgtggtc
49381 tgctggcttc aggagtgaag ccgccgacct tcgcagtgag tgttacagct cttaccRcgg
49441 cgcatctgga gttgtttgtt cctcccgtcc ggagttgttc attcctccca gtgggtttgt
49501 gatcttgctg gcttcaggag tgaagctgca ggccttcatg gtgagtgtta cagctYataa
49561 aggcagtgcg gacccaaaga gtgagaagca gcaagattta ttgcaaaaag cgaaagaaca
49621 aagctcccac ggtatgaaag gggacacaag caagttgccg atggtggctg gggcagcctg
49681 cttttattcc cttatttggc cccacccaca tcctgctgat tggtccgttt tacagagagc
49741 tgattggtcc gttttgacag ggtactgatt ggtgcattta caatccctga gctagacaca
49801 gagtgctgat tggtgcattt acaatcctct agctagacat aaaagttctc caagtcccca
49861 ccagattagc tagatacaga gtgctgattg gtgcatccac aaaccccaag acagacacag
49921 agtgctgatt ggtgcattta caatcctcca gctagacata aaagttctcc aagtccccac
49981 ccaactcagg agcccagctg actttgccta gtagatccca cgcaggggcc gcaggYggag
50041 ccgcctgcca gtcccacgct gcgtgcctgc actcctcagc ccttgggtgg tggatgggac
50101 tgggcaccgt ggagcagggg gtggtgcccg tcggggtggc tcaggttgcc tgggagccca
50161 cgggggtagg ggggtggagg ggccttgggc atggcgggct gcaggtcctg agccctgccc
50221 catggggagg cagctgaggc ctggcaagaa ttcaagtgca gcgcaggtgg gctggcagtg
50281 ctgggggacc cggtgcaccc tctgcagctt ctggcccagg tgctaagcct ctcactgccc
50341 agggctggtg gcaccagcct gcggcgcaga gtgtaggacc cactaagccc acgcccaccc
50401 agaactcacg ctggcctgcg agcactgtgc acagccccag ttcctgccca ctccactccc
50461 tccacacctc cccacaagca gagggagccg gctctggcct cggccagtcc agagaggggc
50521 tcccacagtg cagtgtcagg ctgaagggct cctcaagtgc agccagagtt ggcaccgtgg
50581 cctgaggagg tgccgagagc gagcgagggc tgctagcacg ttgScacctc tcactgtggt
50641 gaggaataag taagattaag cgcttactac agtatctggc atgtgatatg caatcaaaaa
50701 atgattattg cactgttgtt accattgcca acttcactgt gaatatacaa ctttcttttt
50761 gaagtataac tcttgggata attttagcat catttttgtt gaggcttaga aaattacacc
50821 tcaaaatgaa ggccttacaa gcagccttag aagccaaact ttctctctga ccttctcctg
50881 tcctcttgtc tctggcccct cattttcccc agagggtagc catagagact agaatccctc
50941 tcccctcaag gcaggtcata gaaactagaa cttacagagt tattcctgta tctttgagtc
51001 ttcattctga aggctcttat gtcttgtatc tcttgtgcct tttaaaacta tgatcaaata
51061 tattttatgc cttttcttct attaatgtcc cttttgtcag ttgatttcag caaaccttca
51121 gagaggcaaa ggggaaggtc tttcttggcc cctataattt catgccatat ttgacttttc
51181 ttggcctttt atatttgaca acaattttct gatttctgat ttcctgattt acataataat
51241 caattttata tatgtattat gtaagtattc cctactaaca gtgactctca ggttcctaga
51301 tgatgtctga ccttggtttt acttgtcttt aaaaagtgcc actaaattcg ctattgtgac
51361 atctagtagc tgtcagtgat tctggagcaa ctattggaat catagtgtta tttctggtga
51421 catcattaca atgtaaaact acagaatttc ctctcaattt taattcttca tatagagggt
51481 tcaagattct ttctgtaagt gcaaaataat cttagaaaaa atacatttct gaattgatag
51541 taacaggatt tgcatttata attttcaaat gaaagacaat atgctaaaag atgaattttg
51601 tgatcatctg taacatgttt ttttcagctc tgatgaagcc ttcagtaaag tcaatttaaa
51661 ttaccgcact gaaaatgggc tgtctctact tcatttatgt tgcatttgtg gaggtgagta
51721 cttgaaactt agtacttctt aaactggtta tatgtgtata tcgtcagtga cttgagctgc
51781 ttaatagtct gcaaaagaat tctattcata ctcaattttc ccttctgctt tgccttttcc
51841 aaccttgata atctcagttt aggcagtaac tatcaggcag aatattccaa ttgatttagc
51901 tttaaatata agcttcattg tgttgctacc ggaaaccaag tccctcagtt tgcttggaaa
51961 tcaaaaagca cttttcaata ttgggcatgc cagtcaggga ttaacttaaa ttcagaagca
52021 cttaaagatt ccccaaaata tcatcaagca gttgcttcac aRtattcaac aagagtatgt
52081 ggaaaagtga taaatgccaa agataagatc taaaagtgaa gattgatcga agtgaagatt
52141 aagagtttaa tttggcctac actttagttt gttttgttta tcaatgtatc tcaagtaatt
52201 tgaatggtgc ctggcctgta atagccactc agtaaagtta ttgaattaat gaatgaacca
52261 ttaatattta ttttgttaat ccaaactaaa ttcattgagc ttaacttctt aaaatggaac
52321 agaaatgtgt aagtgtcaac tctaaccata ttccttaacc atttctccca aacaaaccaa
52381 acagactctg cttaacagat tgttctctca acttcaaacg tgccttccca accttggtta
52441 tatccttcat atttctttga tctaaataag ctctactgtt aataatgttc agataaatcc
52501 tctacaatta gattttttaa tttaagcttt ttcactaata gtttattatg gtgaattctc
52561 ttatgtgttt atgtttcaaa accatctgat gatgagggta ctaaataaaa aatctaagac
52621 agagtcaaaa tacacagcat ttgaataaag ttttataaat ggaaaagaaa tatcccctag
52681 taagtaaggt tgtcaattaa tagaaaactt tacaaatggc ctgcagaacg cagcttgaca
52741 tttttataca gctgtatggc atttatcatt aggtcaaaaa gagtctcaaa ctcaccccat
52801 ccccacaatg atttagcctt ttttcatttt tctctttaag gcaagaaatc acatattcga
52861 actcttatgt tgaaagggct ccgcccatct cgactgacaa gaaatggatt tacagccttg
52921 catttagcag tttacaaggt aggacacttt aattcccata aacactgcat tggaactaag
52981 gatagtgtgt atctttaggc tttttttttt ttttttcaaa ttagtaatca tggaaaattt
53041 tcagtgacca gaggcgttac attactaaag gacttctttc tctttattga gcagatacct
53101 gctgcatact agacacatac tctttttaat gctttctgta tttaactcat ttaattctca
53161 caagaacccc atgagtgaat atgattatta tccccaaggt tacatggtta gccaggggtt
53221 agccaggatt taagacaagg cagtctagtt ctgttgccaa agctcctcat cagaacacca
53281 tgatgcctct gtgcagagag agatgaggtt gtatttaaag acaaaagaag cacactgaag
53341 ctgtatttct ttactgcaaa tttttcttaa aaaacctttt tgctttagct gtttattttc
53401 ttatattagc ccctggctcc aacctaatct cagcacctga tagaataata aatataatag
53461 tggattggac aaactgggat acttagtgtt ggaattgaac cttgagattt tcataaatat
53521 aaatttataa aacatacaaa ttatattatg cattgatcat tttataatta taataacaat
53581 ttctactttg tatttattat gagctaaata tcatactaag tttaatgtat tttagtcatt
53641 aaaataactg catattagga tttactttac agaaaatgca attaaagact aaagtagata
53701 cctggacaat attagaatag tgattaaagt caagtacagt tggctcatta ctcccagaat
53761 cttatttgta tattgcgtat tttgttcttt ctcattttca agcgagtctg tgacagaatt
53821 ttatttcagt tttgtgtgtg cacgtgtggg aggagggaca actttttgct tgtattagga
53881 accccctgca ctatctccct cccccaactg ctagagagtt tgtcattggg agggaagagg
53941 accttatttt cccatgatct agcatcacaa attcctgtaa ttcatagcgc aaatactcta
54001 aagtttcatc tcttttcatg cccagtcaat gcctagtcaa ttcttctaat tccttctggg
54061 agaaagcctc agttaagtgc taaattgtct ttagtacctg ttaattatcc tgctaaacta
54121 tgaaacattc tgagtttcca gtgtagaaaa cagcatctga tgttgacttt tcttctgaaa
54181 ggcaggaggt gaaagtagaa gagctccaag gaacaggaag gtagtgaatg atagtcatgg
54241 cactgtatga aaccatgaat tctgaacctc accgtctggg agattttttc tgtattagtt
54301 cattttgcaa agatttagca tgacattggc acacaaatgg gttctgaatc atttagtcct
54361 acaatattta gagaatatat ttcttcaacc tctgtttata ataattaaat ttccactttt
54421 agagttttct ttgctctatt tttatgtttt tttctatttt agagaagggt gcataaacta
54481 taactttttc atagcaagtt taaatgaaaa tttagattct tgggaaacaa agcaggcaaa
54541 aatattaaaa ggccataaga aaatgcatag ttattttgca aatttcttaa caaaagtgaa
54601 aaacaaatta aagttactat ttcattttaa acacaaaaat aatataaagt agttgtgtgt
54661 ccagaattgg tggattcttg gtctcactca cttcaagaat gaagccaggg accctcgcgg
54721 tgagtattac agttcttaaa ggcggcatgt ccagagtttg ttccttctga tgtttggatg
54781 tgtttggagt ttcttctttc tggtgggttc gtggtctcgc tggctatgga gtgaagctgc
54841 agaccctcgc agtgagtgtt acagctctta aggcggcacg tctggagttg ttcattcctc
54901 cccgtgggtt cgtggtctcg ctggcttcag gagtgaagct gcagaccttc gcggtgagtg
54961 ttacagctca taaaggcagt gtggacccaa agagtgagca gtagcaagat ttattgcaaa
55021 gagctgaaca acaaagcttc caaagtgtgg aggggcaccc gagtgggttg ccactgcttg
55081 ttcaggcagc ctgcttttat tctcttatct ggcccccacc cacatcctgc tgactggtcc
55141 attttacaga gagctgattg gtccgtttta cagagagctg attggtccat tttgacaRgg
55201 tgctgattgg tgcatttaca atccctgagc tagacacaaa agttctccac atccccacta
55261 gattagctag atacagagtg ccaattggtg catccacaaa ccctgagcta gacacagggt
55321 gctgatggtg tgtttacaaa cgttgagcta gatacagagt gctgattggc atatttacaa
55381 tccctcagct agacacaaag tttctccaag tccccactag actcaggagc ccagctggct
55441 tcacccagtg gatcccgcac aggggccgca ggtggagctg cctgccagtc ccacgccatg
55501 tgcctgcact cctcagccct tgggcagtca atgggatggg gcactgtgga gcagggggca
55561 gcacgctttg ggtaagctcg gccatgcaag agcccatggc agggggtcgg ggggaagctc
55621 aggcatggcg ggctgcaggt cctgagccct gccgcacggg gaggcagcta tggcctgctg
55681 agaaatggag cacagcgcca gtgggccggc actgctgggg gacccggagc accctccgca
55741 gctgctggcc cgggtgctaa tcccctcact gcccggagcc ggcaggactg gccggccgct
55801 cggagtgcgg gcccgccaag cccacgccca cgcccaccca gaactctagc tgggccgcaa
55861 gccccgccgt gcggccccag ttcctgcccg tgcctctccc tccacacctc cccgcaggcc
55921 gagggagcca gctccagcct cggccatccc aggaaggggc tcccacagtg cagcagcggg
55981 ctgaagggct cctcaagtgc agccagagtg ggcgccaagg ccgagaaggc accaagagcg
56041 agcgagggct gcaagagctg ccagcacgct gtcacctctt agttgttcac actaccaggc
56101 attaaaccta gtaaccatta aatgcattaa acctacttct aattatccct tgacagaact
56161 actccagtaa gtatataatt cattttgggc tccagttccc ttcccccata tagtattaat
56221 aactgtttaa ttttaatatt atttcaaact tacaaagaca attgcaagaa tagtacaaga
56281 aactgcttat ccaggttcat taactgtttg cattttgtcc catttccatt attttttttW
56341 agaaccattt gacagtaaat tgtataaaac atgccctgtt gccacttcag tcttcatttc
56401 ctaagaacaa gaaaattcac ttacataact ccaatgcaat tataaaatta aaaagaacat
56461 tgagatgata ttaacattga taagatatga taatctatag ttcaaattca agttttatca
56521 attgtcccaa ttgtgtcatt tatagattat attttcttgt ccaggatagg attcaatcca
56581 caatcatgca ttttcagttt tcttatttct gtaatctccc ttactctgaa agaatttctc
56641 acccgatcct tgtatttttt tatcttaata tttttcatgc ataccagtta tttatacata
56701 tttctttgaa tttttttggt attgcaatcg aattttattt tgttcataac actcacaaaa
56761 tgaataatgt aactctccca tccttttgtt cactacatca aatagctctt tcaattatac
56821 accctggcat gctgggcctg actcattgtt agaggaaagg ggtcccgatc caggcctcag
56881 gagagggttc ttggatctcg cgcaagaaag aattcagggc gagtccacag tgcaaagtaa
56941 aagcaagttt attatgaaag taaagtggtg aaaggacagc tactccatag acagggtagg
57001 atgttcctga aagtaagagg aggagcacat ccaccctagg tacaatgctc atatacatgg
57061 ggagatgtgt tctgctgcaa gggtttgtga taacatatta attttcttaa ttgctatatt
57121 ttgcaagaat cgatattatt atctttaaag caaaattagg aatgcctttg ttctacagat
57181 atcaggatat ctggacactc ccaagtctgg gtctgttcag taaacattat gaacttgttc
57241 tttaactgta aacatctaga ggttaaaaat gcctaacttt tgggaggccg aggcgggcgg
57301 atcacgaggt caggagatcg agaccatccc ggctaaaatg gtgaaacccc gtctctacta
57361 aaaatacaaa aaattagccg ggcgtagtgg cgggcgcctg tagtcccagc tacttgggag
57421 gctgaggcgg gagaatggcg tgaacccggg aggcggagct tgcagtgagc cgagatcccg
57481 ccactgcact ccagcctggg cgacagagcg agactccgtc tcaaaaaaaa aaaaaaaaaa
57541 aatgcctaac tttctgagaa tgtaaccccg taagtctcag cctcattttc ctattttcct
57601 agccctcact caaaatggag ttgttcactc tggttcgaac gcctctgaca tcatgactgt
57661 atattttcta atcaatagag taatctctgc tttcattaat aaaagtgaag cagatattta
57721 gctatttaat accacatgaa tgattaatcc tcatacatct ttttgtttta gtttgttgag
57781 tttttcacag tgtttagttt tattgaggtt taatatatac caaatacaat tatcaatttt
57841 aagtctacaa ttgttagctt ttgaaaatgt atgtaatcat gtaaccatca tcacagtcat
57901 gttataggac atttctacta taccaaaaag ttccctcatg ccattttgca gtcagtctcc
57961 ttctcacctg gtctctggaa acaagtgttt tctgtcacta tagttttctc ttttctagaa
58021 ttttaaataa atttattaca tccagtatgt tttcttttct atatggtttc ttgcacttat
58081 cataaggcta ttgggattca cccatgttgt atattctgta attaatgctt ttcttgtaga
58141 attgtattcc cttatatgga tataccacaa tttaccattt acctgctgat ggacattttc
58201 ccagattttg accattataa acaaagctgt tctgaacact cacatacagg tatttgtttg
58261 aacatatgtt tttatttctc ctgggaaata cctaaaagtg gaattgctga gtcacataat
58321 aagtatatgc ttaattttat gagaaactaa caaacttttt aacaaactag caattccttc
58381 ctacattccc atcagcaagg tatgagagct gtagtttttt cacatccttt ccggcacttg
58441 gtgtggtcag tctttttttt tttttttttt tttttttttt tttttggcta ttctattgga
58501 tgaattttag tatttcatta taattttaat ttgcatttcc ctgaagacta aagaggttga
58561 ataggttttt atgtgcttat taggcatcct ttatttttta atgtagtgtc tgttaaatct
58621 ttttgccatt tgtaattttg tttattattt tcttgaattg tgagggaact ttatctattc
58681 taatacaatt cttttcttga atatactttt gcaaaaattt ctctcagtgt ctgacttgcc
58741 ttttcatttt cataacagtg tcatttgaag agtaaaaggt ttttgcatta tttttaaact
58801 tatgactgta gtgattacca tacagttata gattctcaac atttcatagt ccactccctg
58861 caaatgttga tctacttcac ttaaaatata agaaccttcc agtagtatag tttcatttta
58921 tcttcattct ttgtgccatt gttgccatat acattgcatc tatacatgat aagaacctaa
58981 atatattatt agaatttttg tgttaaacat ttatatcttt taaagaaatt aataagagag
59041 aaaatatgct tttcggaagt ttgattataa taatcctaca tatggttttc tgtatttaaa
59101 actctttgag attcactgag tttttatatc tgtaaattta tggtttcatc aaattcagaa
59161 attttgacca ttagtttttc aaatacatat gttagattgt ttgataattt tccacatatc
59221 actgagtctg ctttttttct tccttcttct ttctttctgt tctccaaatt agattatttc
59281 tacttatttg aattcaagtt cacaaaccac ttctctgcca tctcccatct gataacaatc
59341 caccagtgaa ttattcattt tggttgttta cttttccgtt ctaggatttt tatttattaa
59401 gattaattaa gatataattt caatttctct gctatgatga cacatctgtt atttcatttt
59461 tccatatttt ccttcaaggt tttgaaccta ttatttgtga ctactttaaa tgtccaatct
59521 gctgttttca acatctagat tagctcagta tttgtttcta tttcatgttg actacagRgc
59581 acatttttct gtttcttcat atatcaatta attttttatt gaaagctaga aattatgtat
59641 tatgtgttat aggaaatctt tatcatgtca tcttccttta aagaatgttg agtttttttt
59701 atgtttgttt ttctttcatt tttggcgggt agttacactt ctggtggata catttcaatc
59761 aaatcagtct tgatttgatt ttttgttagg ctgaaggtat ttcagtttga acttagcctc
59821 ttggcttacc tctttttttt tttttttttt tttttgaggc ggagtctcgc tctgtcaccc
59881 aggctggagt gcagtggtgc gatcttggct cactgcaagc tccgcctccc ggttcaagcc
59941 attcttctgc ctcagcctcc ggagtagctg gggctacagg cgcccgccac cacgcccggc
60001 taattttttg tatttttagt agagacgggg tttcaccatg ttagccagga tggtctcgat
60061 ctcctgacct tgtgatccgc ccacctcgtc ctcctaaagt gctgggatta caggcgtgag
60121 ccaccgtgcc cggccgcctc tcggcatacc tcttattcct agcatgtggc tctcacacct
60181 gaacatggtg cttactccta aagtatgatt ttttggcatg tcacctgaat tcccaagtct
60241 ctcagtaaag tctcttcata ccagctgaca ggagttccaa aatccccccg tactacatga
60301 cctccagtat caccaccatt caccttttag caataaatca ggtgatcttt tctagatctt
60361 ccagaatctt tctctgtgct tgtgcagccc agctcaacaa tacataatgg atctccatgc
60421 agatttctgc agtgccctct ctgtgcagct tcttcttctc ggttaccctg ctccacaaat
60481 acagcccctt cataatatca gaactctcat ttacactctt aactcagtga gacttcctat
60541 tatgctttgt ggcagaaaag tatttcaggc agaaaaccat ggcaatcatg ggatattgtg
60601 tgacttgctt tatatctttc tcttaaagga cacagctgtt tgctcatgct cttcagtgct
60661 tgagaacagt tatgtcatat attttgttcc attttgtaga ttttatttgc cagtagagaa
60721 agtctatata agttgttctg tcatgcccat atctactttt gcattgcttc caaaatgatc
60781 Wgaatgaaac aaaaatctat gatatcattg ctcactttaa cacttactat tgtcatccat
60841 tgcctatata atgacattca aactcctaaa tatgagactc aagatccctt aatttataac
60901 ttttctggaa tcactttcca tactcttttc ctgtagtctc tgcctgttca accctaatgg
60961 ttttcaatgt aatgtgcatg aggatcatat agtaacatac gtttaaaatg aatatttccc
61021 tttctacttt actctcattt aaattggtac atctagggta ttctaggaat ctaaattttt
61081 aacaaacaac ctaggaattt tgatgtaaac aatctaggtc tacatattgt ggattactgt
61141 tcaagcgtgg caactcaaat tatggtcaca tgatcagtag catccacccc aactaaaaga
61201 tttcagaaat gctgctctca tttcctttcc agccctattc aaccagtact attcaggcgt
61261 ttctagagaa atttaaccaa taggattaat ggatctatct atctatctat ctatctaatc
61321 tagagacata tttattatag gaactggctc acactattat ggagcccaaa agtcccacga
61381 tcttccgtct ataagctgga gaatcaggaa agctgatagt atgatttggt ccatgtccaa
61441 agacttgaga accaggggag cctatggtgt aaatcctatt ctgagtctaa aggcccaaga
61501 acgaggatca gtgatgtctg agggcagaat atggatgtct cagctgaaat aaaaacaaat
61561 tcaccttccc tctacctttt agttctattc aggccttcca aagattagat gatgcccacc
61621 catattggtg agggtgatct tctttttcag tctactaatg aaaatgctgg cagggcatag
61681 tggctcatgc ctgtaatccc atcactttgg gaggctgagg caggtggatc acttgagctc
61741 cggagtttga aactaacagg gtgaaacctt gtctctacta aaaatacaaa aattagccat
61801 atgtggtggt gtgcgcctat agtcccagct acttgggagg ctaaggtggg agaatcactt
61861 gaagtcagga ggtggagatt gcattgagct aagattgtgc cactgtactc cagctgggca
61921 atagagcaag accctgtctc aaaaacaaac aaacaaacaa acaaaaaact aatgccttct
61981 ggaaataccc tcacagacac ccagaaataa tgttttacta gctaactagg catcccttaa
62041 cccagtcaag ttggcaccta aaattaagca tcacaaccag aatgtacatt tttaaaaaaa
62101 tctcagctga tgtatttgta gattaaagtt tgaagattgc cattttagat aactccattt
62161 tttaggccaa acagttccac atgtctttat ttttgttttt ataatttctt ctgcttaaat
62221 attttttaat ttcttttcct gatgcaaaat tattacttat ttaaaaccaa gataaactga
62281 gttttattga actcgcagac agaaattatt gcactctctt ttgggtttca gttattaagt
62341 ttacattatc ttttattgta gcacttataa ttatttattt atttgcatat ttcaaatgtt
62401 ggtctgtgaa ctttggacac tgggactaag tctttttctt tgattcctca gtatatgtga
62461 cctgtaaagg atccttgaga aatacttgtt tggaaattag tgagtgtcca aacattagaa
62521 caatacttga catttgttga tattatgtag cttaagaaag actgtcagct tagaagctag
62581 aatacttctg ttcatatctc agttatgaga cttgctaatt atgcatattt aggcaaattg
62641 agttttcctt atgctcctca attttctaac ctctaaaatg aagcagatag aattatctat
62701 tttattgtgt agtttagagt tttaaggaaa caaatcatat gcagtactta gcaaaatacc
62761 tagcatatag ttaatactta ataaaaatta accattattg ttgttgaact ctaactttga
62821 caaacattta ttggaaacta acatgttttt cattttgcat agaaaaatta aaagaaatgg
62881 attggatttt ctggattatt acattctaaa gagatgagaa aaggtaatcc taacaatata
62941 aaagaaatgg catctatact tagatcaatg gactacaaac atcttttatc acgtcctcta
63001 taaaattagc actcccaaac acatatatgt gttcataaat tatatacatt aacaaaaaaa
63061 cccatcagtt aatagcttaa gacaaaatct actctttgga aaacaaccag tgttaaagtt
63121 tgtagctata catttatatt tcaaatagcc tttttgataa tataaaatat tttgacaagt
63181 ttattacaaa tatgattaga ttaggaaatt gatttatatg aagctcagat tggtagaaaa
63241 aagtaccagc tttttctttg ctgcttctta ccttagtaat atatatgttg tgtattttct
63301 tcacaggact cttttaaaga tacctgccaa tttcgtctat tcagttgaag tgtctattca
63361 gttaaaattt gatattaaaa tttataatcc cacttacttt ggctcacata agctacagca
63421 catccccaat aactaaaagc taagaaaaaa aaaagagtga gaggcagctc tcagtccttt
63481 cccatgtaga attttaagta tatattatac tttgggtact atatgtgaca tatgactagc
63541 tgatatatga actgaagccg ccagtgtaaa tttacatgtt aaacatgaat gaaacttcat
63601 ttatctttat atataaatgt atataagcag attttctaat tctttttgta ccctaatgaa
63661 ttttattaca agattcctgt cacatttata tccctctata gggcatactt ctttaggtgg
63721 tatctaaatt gtattcctaa aatgaaacac aagactttgg ggaaaaaatt gagacctctg
63781 atatagttta gaagatctta attgagaaag ctaatgaaca aaatcctatt agaccatcta
63841 atttagcctt acatgtaact ctcattcaat acacagacaa gccacttagt gaaatttctt
63901 tagtgagaaa gaagtagcat tttgattcat taacttattt ttaacatttc gtatgataaa
63961 agcagatatt gaatggtaat ggtcatttat cccatcctat atatttcttg caagatttaa
64021 ttcctatcat tcagaaacaa ctcattttat atatgtatta caaaagggaa ggacatgaat
64081 gggggaaaaa tcgaattaaa cctatgttgc ctggcttacc agacctaggt attttttgct
64141 acgtaactgt gcccatcaga aaactctgac ttttctatca gtggcgattc gtagcctgaa
64201 tcattgtatt aatatctttt atcctgactt tttttttcct ccttagcaca tatatttgat
64261 tgcaaagttg aaattttcaa ctatcctgaa actaaagacc caaagtaagt gtttcatagt
64321 ttctaactgc tgtcgattta gaccaaggtt caacagcctt ggcactactg acaatttgga
64381 ttggataatt ctttgctgtg ggaggctgtc ctttgtgtta taaaaatgtt tagcagcatc
64441 cctgtcctct gttctctaga tgagagcagc cacttccctc atgcccagtt gtgagtacca
64501 ataatatctc cagatatcac ccctgagagg caaaaatcac tcccagttga gaacaactga
64561 tttagaggac agatttcaat attcattaac ttaaatggat tttttaaatc ttaattacct
64621 ttatatttga acaaataaag tttcctgatt aaagactgca ttttccctaa atgggaattt
64681 gacaagatag taataagaaa taatttgaag aaaaaaaaaa ctcaaaaaaa aaagaatccc
64741 actttttgca tatttaacta aattctccag ttagtgatga cttttaaaca ctttaatagt
64801 agattttcac ttaagaaact agagaaaatt tttactcata aattacagca atcattaaga
64861 tagcttgttt atatgcagat ttccctttag taatgaaata tttcataatc tctttctaaa
64921 tgaacacatt ctcaataaaa agttaatagg atcctagctg aagatggtaa tttgcaattt
64981 atgcttcaat tettacacca gacagtagta tttcctggaa aaccttccct gatccctccc
65041 aagtttgggt taggtattgc ttcattgtac tctcttagct cctagtactt actatgctgt
65101 gtatgctact gtatattatt acttagttaa atctttatat cttcctctat attagcggtc
65161 acaatctcac atattttaag gatgacataa ataaatgaaa gacagacaat gataaatggg
65221 aagtaaaact caagactgaa tatttttgag atatgagaga gtggcaaaga ctgtggtaac
65281 ttagaaaaca tatgccccat gtaaagggaa tggtcactct tcagcttcag ctaatcattg
65341 tcatgtaaaa atgtagaccc attatttccc aaaatttcag agaatcataa attatgtgaa
65401 gtttcctaat atttaaatgc tggccattaa tgcagatttt tagtcataaa tactcaacag
65461 gctaagccat atatatttcc attcctcttg tagcctgttt gtaatctctg atagtaatta
65521 tgagcatcat caaggcagag accagatcca agttgcttat catcttattc tgagtgctta
65581 gaacaacgct tgatatatat acttaataaa ttgatgtttt ataagtgaag aatgaagtta
65641 tagttctctg gtaactgggg ggaagaaaag tgtttcaaag gaggtaggat gaggttgaca
65701 gtgggcaaaa tggtcctatt tgggccatta gaataggaaa ttaggaaatt gtcagatacc
65761 tctttaaggg atattttagt aaattttggg gagaagagga tataaaaatg ggttgaaaat
65821 aaatacagtt agggaaatgg aggcaataaa cattaatttc tcttccaaaa agtataagat
65881 tgggcaatat ttgaggaatg gccagatcag gaaggtttct gaaacagcat tgtcctatct
65941 ttttaaactc ttgctcctta aataaacata aaagttcaga gtttatttaa atgttatttt
66001 taaactttaa aatagatatt atgttatagc taaaaacaaa tttaaaaaat tagaatattc
66061 attatgcctt ttcaagtagc atgtatttac ttcccccgcc ccactgcaat aggtagagat
66121 tcttattatc ctcttcctgt taaatcatct ctatattatt aaatgagaga tgatttaagg
66181 atgttcaaag gccaattgga ggcagcctgc aggaataaat acattatgga aaatgagaaa
66241 atagaagaag gagggatggc agaggtgagg ggaaaaaata ggtccaaagc aagggtacag
66301 ataatctaag agtatgttac ttctcttttt ttcttttttt ttttccaaaa tttcaagcaa
66361 agtcaagtat ttccaccaca ctgaaactct taaaaactga tatcttttgt gaaaataaat
66421 ccagaattgt ttcaacagga gacatatagg tatgaacctt tgtgagttga gcagttattt
66481 tcatactgat taatggatac tttcactggg gatgtctatg atgcacgagg cagctctagt
66541 ccattaaatt ttaatgccta gaactaagtg catttcatac tgaagccctg aatagttcct
66601 tgtcctaaag gaaaacttaa taatattctt caaagcctcc aaaattactt ttctaaaaaa
66661 acctttttct ttataaaaac aaataaactt taacaattgc tatgctggtg aagaaaaaat
66721 atacttagag aaacatttta aaaactttta tttatatgtc cctattttat atccagaaac
66781 ttagttttct ttccaatcaa agttcagctc cttcttggag tttggtatga cacttcaggg
66841 aatattagag gtgaataagg tattacagaa aaaaatttag cccaactctg taaccctgca
66901 gataaagaaa tggaagtatt ttatgactaa acatctcttg ggacagagtg gactaaatca
66961 taaggtgaat attctcatag aagtaggcca atcttggggg tgatacattt aatatgaata
67021 taagcttaca cctgtaagta tcttgagttt ataagcattt gcacatacat tatttcattt
67081 gatctttatt acaatcttgt aaggtaagta aggtaggtat tatatttctt tttataaaaa
67141 tgaggaatat aaggtcaggg ctgatacatg aaagacaaat tattagcagc tgaagggtaa
67201 ttggtgggga gggagaaata acatgatgta ttaagaaaag cataatatta aaaatcagaa
67261 gacctgattt caaatcccag ttcagcctca gtttaaagtt acattaaaga aacacatttt
67321 atgctatgga atgccaattg ggttctctaa aaagcattct ctgaaaagaa tgtaggagta
67381 caagaggttt atttaaaggt gacacctgtg aaaggaaaag gaatgaaaca gaattggtta
67441 tgaggtgcca tcagatccca atacagagct gctaaaatct ccgccagccc attgaggagc
67501 tccagaggaa aaattgccta tgRaaggagt gccacacggg ctagaaatgt cgaggccctt
67561 cttttaccac caccttactc agtcattgac tgggagtaag gtccaccctg agaagagact
67621 gaacacagct ctaatgctgc agtgggtcct gaaataactg agaaagctgc cagtgaacta
67681 ccatcctgcc acactcttca taaagggagg tctcagtggc atatctattt ctgccacaca
67741 tgaggaaatg ctcatgattc tataatatat gaaaaaagga aattacctat atgtagaatt
67801 agatcaatag tgtacataat aacaattatt atgtgtcaag cattgtacta aatgaattac
67861 agcattatct gatgtaatcc tcacaacaat gctatgagaa tgatacaatt gtatcttcat
67921 tttacagaca aaaactggac agctcaaaag gttaagaaac atgtcgcaaa tgtaggaagt
67981 gcccatcaat attgaaacac gagtttgctt tgctgggata gcttgtgctc catctggttg
68041 cacaaacata tgtacatagg acaaagaatg gaagggaaaa tacacacata aataatagtg
68101 attatatggt agtactatgg gttattgaat tatttattca ttttctttgt tttttacatt
68161 ttcttctctg aggtattctg gttgtctgtt gaggcataac aaactatccc aaacttggtc
68221 ttctaatgca actattttat tattctcatg gattcttagt tcaaaaattc agacaggatg
68281 ccgtgtggat ggcttgattc tgtcccacaa tatttagagc ctcagctgag aaaatgtgaa
68341 tgaatgggtt tattcatcag ctggtagctt ggaattctct ggaggcttaa cacactgact
68401 ggaataagtg taaggctgga cttagctaga acagttgatt ggagagcctt catgtgcgat
68461 gtaccttctc catgtggcct gcattttctt ataccatggc tgacacaggt tagtcagatt
68521 tgttacgtta tagatcaggg ctcccagagt gtgtttttca gcaaacagaa aggaagctgt
68581 gtggtcttct atgtcctagc cttagaaaag aaacactctg ctccacgcta ttgatcacaa
68641 tccacccagg ttcaagggga aggggcatag atagcaaata tctgtgggtt gagtatagat
68701 gaatgctcac catgttttaa aaccaccaga aggtatattt tgtccataat cagaagaaag
68761 tacattttta tacatcagtt tcttttctat actgaaatag agttgaaatt tttttgttta
68821 ataaataaat tttaaaaatg gatgtaatat ggtagtagag gatttgagct ctgtgatata
68881 gtggttgctt atcttggctt tatccatagc aataatcaca gagctaacaa taaggcagga
68941 tattaagtaa gcattgtttt agagttttat ggctagtaca gagttgcagt tactaccatt
69001 acaaaatatt tttatccatt tacatacatt ttgggagatc tattctacct caaattctat
69061 ttctcaagga tatagctgga gYgctttttt gtctaagcct cattcttcca cacatggatt
69121 ttcttctgct taaaaataat aaatatgaca cacacaaata cattacaaag agcttattta
69181 tctcacactt atagggtgcc tctgtgtgtc acattgaata ataatgcttt aaatttggct
69241 agagagtgca taaaggaaac ttgtcagttt ccacaagact cttttctaaa caagtcttaa
69301 gagactttct tttaaaaaca ttgccattag acatttctta tatatggtaa actgcaagca
69361 ataaatgaga tcaaacttag agtattcaaa atttgcctaa tatttgcatt ttacaggaaa
69421 attttttcca ggaggtgtgt accatattgc tgactcttaa aattattcca ttaggacaaa
69481 atattccagt agagtaagag gcttatcagt taaatacagc aaaagtatgt cctctcaagt
69541 ttttccttga gactcgatca ggaaaaccac tatggaaagt cagaagtgaa gtacagacgt
69601 tggagtccaa cagacctggg tttgcatcta ccttcaacac ttacaaagta aggttcagtt
69661 agcactttaa attctttgag cctgagtgac atcggctata aaatagggtt aataattatt
69721 ttctctcata ggtaaattgt gaagcttaaa tgagaggata tagatagaac atttttcatg
69781 gaagttggct catagtaagc aatttatatg cagcaattac tgctttatgt ttattatctt
69841 tagcatagct gcataagata aaagttttat tttggcagta ttcagttaaa aagtatttag
69901 atcaattaga ggtcaatctt gagaaatcca accaaggtat gaaaggataa attattactc
69961 ttaacttttg accttaccat ttgcccattc tgaaggaatc ctaatRtact ttaaaaaaat
70021 tccacaaata ttgactgaat aaggagaaaa aacaaagata cttgaagaaa ggataaatgt
70081 gtgtttacta aaactgccta atagataaat gtttcacatg ctctgtgatt tacataaaat
70141 ttattttaat ttagcctagt acagtgcttg tcataaaata gacattcatt aataaatatt
70201 tgttgaataa aagagtatcc atctttctac tgatttatac aagttattta tgtattaaat
70261 atgtaaacaa tttgtcagtt ttatatgttg tgaatatttc tccaactcgt cacttgcctt
70321 attgtgtttt taacacttta atttgctcaa atctatcata ttttctattt aaaatataac
70381 tttatgctta aaaagacctt cectactact ctgcattgaa atttctgacc atctgcMggg
70441 aaaatgtttt aaggcgatgt ttttcctatt tatctcaaga ctaatcatgc ctttagccct
70501 caccaagatt attggtaaag tgagagttaa ctcctgtgaa ctgttttctc tggaggagga
70561 attctcagtt tctggcagcc tatccatggc taaactagta gacgttttct cgcttccagt
70621 actggtacag cctttttcca tgttttattc ctttgtttgt tgcagtgcct aactcgtgaa
70681 gcagagggag tggagttagg aggaagaggt aaagggaaag gagaaagaga agctaagtga
70741 ttaaatcaaa tcaatatttt atttggaagg tactataggt attatcagaa caattttaag
70801 gtggttacaa ttactctttt tttatataat caaggaaatt agcaaaaagg agtgwcagaa
70861 ctgctccagt gcacatagtc attgtgagag ctgaaattct aattagggag gctaattcta
70921 tgacctgcat cttaaccctg ccttatatgc agctcaaatt taacatgtga aaacgaaaca
70981 ttttacttct gcctcaaaat ctgcttcttc ctggttcttc cctatctctc tatcattaat
71041 ttccctacta cttattgcac ttggaaaaaa atccaaatac cccataccat ggcctagaag
71101 gccctgcaag attatacatc tttgacctca tcttgaaaat ttcttttcct ttgtttaatc
71161 atttactcaa cattggcctt attgctggtc ttcaaacaca acaagcttat atctgtcttt
71221 cgacttttgc actagctatg tttcatattt taatacttat ccttgaaatt gtgacttttt
71281 gccatctacc atttatctca aaagtcacct ctgcagtgaa gctttccctg attaaccagt
71341 ttaaaatagc catctaatca tttgtctatt tttatctcat atcagttggt actttaagct
71401 actgtatagc aatttcttat ttgtttactt tttgtctctc cattcacgta aacatagtaa
71461 aatataagct ctgtgagagc agcgatttca ctatctttac tcactgcagt gtcaccactg
71521 ctcagaaaag agtttgaaac accagatatg ctcaatcaat atttgtttag catataaagg
71581 gtatattgaa aagagaaatg cataatcaaa actgggtgta ggaaaatgta tctaattgta
71641 tgcaggatgg actgcaatgg gaaaaagtat tagttgagga gactagttag gaagctgcgt
71701 aatacagagg atgatgctag aaataagaag aaatgtgaga agtataagtc agttaaaacc
71761 agtagaattc tgaaactgag ctgaagggac tctaggtccc ttggaataaa aaagtgccat
71821 tcatataaat aaggaatgtt agatgacaag tcagcctggg aaaattataa acgataatta
71881 taagaacaat ttcaaatttt gcatttgaga tgccattgat aggcaaaata Yatgggactc
71941 agacttagca gagaagtcag gaccaaagat gcatttatca gattgtataR taattaccaa
72001 agtggcattt aggaatggga aagcagctta gggctacatt tccaaatcat acacttttag
72061 aagacagtca gaaacaaaga ataggcaaca aaaaggaatc aaggaatgta tagttttagg
72121 aaagcaaagg agataagaat tttgagaaga aagagatgat ctaatcatag agagaatgac
72181 tacaaggaca ctggatttga tagtttacct ttagaaattg aagaagtgat ttcgggagac
72241 tggtgaggtc cttaatgcct caggtggaag aaacagtcat ggtgacttca cctggtaata
72301 cgatgaaaag agatgtggga aataaatctg ccttagtgag gagtagtgtg agaaaagcaa
72361 aattcaatgt agaataagta tggtgaactc atttgagatt tatgtggaac ttgggtatac
72421 ctacctaaag attgctaaag aaatgagact gcaactgtca acagattcaa tatctttttt
72481 cagaaggctg gaaaatgaag ggaataatag agataaaatc agcttagctt cagtgggaaa
72541 aaaaaaacaa aacttttttt ttaaaacgga gaaaacataa gtttatagtt caagcatata
72601 gagccaatga aagaagaaag gttgaagatg caatatttat ttcactttct tgggagagca
72661 ggtagaaaaa cgggaagatt tggagactat aacattaatt ttactatttg tagctcttta
72721 ccaaagtttt ttcatttttt agaatttctt gtaggccttt atgcaggtgt gacagcatta
72781 agaaatcaaa ctttgccttt taatggtaaa attttcttaa caaacagtat ttgatgttat
72841 atgtatgtaa gtcataaatg cactggccta tcttatgact tgactttatt gctacttggt
72901 gtgttgatag accaaatatt atagaagttg tggtttaaat tcctactttg aggcttaaac
72961 atggaaatct ttgtataaca aagattaaat acaaaacaaa attacatatt gaatttcaaa
73021 ataaaaattc aatgactgtt aattgctatt aatattataa atattatttc atgtatctcc
73081 aaaggcagaa atacaataca aataatatta taaaaaagta agaattactt taattgttgc
73141 acaaattttt caaatttgga ggctcaaata atagttctaa catattcact ggtaaaacga
73201 gtcaagttaa gaaagatatt atgaattaat tgtgcctaga tttaatgata ttatttatta
73261 gtaagaagaa attactgaac tatcatgaaa cagcctactg ggctgcatgt actttgttca
73321 gtacttggtt catactctct tcttaaatgg catatttcat cctcatctct aaaagaaaaa
73381 aaataaacct ttaaactgtt actgtaaatt cctgacctca ctgggagtta attctagttg
73441 ctggaaaagc atattcattg gagtaaccta cctgtaaaac tgagtttgtg gttgcaagag
73501 tctcaccata ggtaatgtcc tttctgtctt tcttgttcaa gcggtagagg attgattaga
73561 actgaRcacc tctgtcattt ggtcctactt tccaccatct gagaactatt ctctggtatc
73621 taatgtgctc ttatgctaga aatcacactt aagtttcctt tgagcacctg aactggctga
73681 taggcagaaa atcaatacat cctgttgcac agcttttgaa cctgttatta gcagaaaagt
73741 aacactaaag atatgtttcc ttacaggata atgcagaatt gatcacttct ctgcttcaca
73801 gtggagctga tatacagcag gttggatacg gtggcctcac tgccctccat attgctacaa
73861 tagctggcca cctagaggta agtcatgcct ttggcacctg tgaaaacaaa ggttatttac
73921 cttttcggtt gttgttctta actgttttga aatactgtct ttgagacttt acaagttggt
73981 ttatttttta gctactgaac acattggggt aaaatttagc tgtataaatg agctttggat
74041 agtcaattca gtcaattttc taacagtgta tttaatcatc aRttaacata aaggtagcta
74101 gatatacaga ggctttatag cagctcagtt tccacaactt gctattttaa ccttggggaa
74161 gttactgaat ctcatgacct ccctcttttc ttcacttata aaataggaat attagtaagc
74221 ctattataat gattaagtta gataatttat ataaatcact ttgtagtttg cttaatgcag
74281 agtaaggaca aaatgaaaaa tcattcactc attcatctac ttatgtatta cttgaatgaa
74341 tatttattca tcacctatta tgcaccggat actgttttag atgctgggat gacagtagca
74401 agaaagtcag gcaaaatttt cattttatag agtttagctg taaagaataa aatagacaat
74461 aaagacaaga aaatattaca taattttaat tagtagtgag taccataaaa ataataaagt
74521 gaggtaaaat gaaaacaacg agagagaagg gggcactatt taaaataagc tgtacagtaa
74581 atatctctga aaggaggtca tataggaaaa gagatttaaa tatattgaga atgtcagcca
74641 tgtaaaagga gagaaaagaa tttcaagctt aaggaatggc acttgcaagg accctgaggc
74701 ctaaaaaggc tgggtgtgtt tgagggacat gattgagcca gagttgttag agtggagtga
74761 gcggaggaag aatgatgaag acaaggtctg gtgatgaatg gttccaagcc aaatcacaca
74821 gtgttttaaa ggtcatagga aggactctgg atcttgtctt aaatttaaag tattaatttt
74881 atatatccta ttatgggaag gacttccatt tgcatgattt ggctaacttc acaaatcctc
74941 atcgaatagt ttttattgcc gctgccattt gatagatata aaactaaggc tcttatatag
75001 taattgcctt gacaaattac aaagctattg aggaaaagag ccatgtttgg aatcctgatc
75061 attttactca aaatcccatg attgtcacac tctatcaatt gtggaaacac caatagctca
75121 acaatgtaaa agatgagaag tctgacatcc ttattattaa atagttatgt tccccctttt
75181 agtcatgttg caattcaatt ataccttctt cactaataca cacacatata cgcacacaaa
75241 ctgtgaacaa atagagctgc atataaaatt atacttgaag cctgtaaaac agaggtgatc
75301 catctccctt aacagtgtca cttcaaaggg ctcttacatt caatacaaat taaaatatct
75361 cgttgagagc aaaatagttt ccttcatgtt gacatttcca ctcctttcca tatcacctta
75421 tttcctggaa aataaatcct tttagtgaga ttcattgtaa atataggtga gtttgtgtta
75481 cttatgagga aaggggaaat tccattagat tcacctaaat ataaatgttt tccaaaaaag
75541 aaagaaagaa actgaggcca gtgataaagt aaatgagtgg taaacattaa gggatctggg
75601 tgaaataatt tatgagttag acactaactt ctagtaaaac atgatcaacc tcttaatgcc
75661 aggaaaatta cagactatgt cttcaaaaca aaatcctttt tttcctaatg ttgttttgat
75721 gatagcatta caatggcttc taaagcaaag tggttaagag cttagtttct tcatctccta
75781 ttcaaatagc tctgttttct ttctttctaa atcataatat ggaagaaggt attatattga
75841 ttttaccaga cttagggcaa acttcaccaa agtattccaa atagatctct actcttgcct
75901 tgcaattctt catgggtttt ctaattttcc tcattagctg atatttgatg acttttatag
75961 tcaatagcta acactgcaaa aagcaagtat agatacatta gcctttattc tcttcttata
76021 tgggggacta attaaattat tgatcaaata ataaagaaaa gggtatccaa aactatctaa
76081 aataattata ttcaaaatga atatttttgt tggagtattt ctttgaaaac tattaccatt
76141 gacttttgac caatgtggga gttaggagca ctgatcccct gtacagttga aaatctatat
76201 atacattttg actaccctaa aacttaatta tttatagcct actgctgatt ggaagcctta
76261 ttgataatat aaacagtcca ttatcatgta tttttaatgt tacatgtatt atatactata
76321 ttcttaaagt aagctagtga aaagaaaatg ttataaagaa aatcataagg attagaaaat
76381 atatttacta tttattaagt ggaagtggat aatcataaag gtcttcatca ccattgcctt
76441 cacattgaat aggcaaagga ggaggaggaa gaggaggggt aggttttgct gtctcagggg
76501 aggcagagat gaaagaaaat ccatgtatat gtgaacttac atagttcaaa cctgtgttgt
76561 tcaagggtca actataattg tagtaaatag tcactgtcaa tatatcttta cccatacgtg
76621 tgaattcatt taacattttt tcagccccta ctttgtctat aaatggttag aatatagaaa
76681 tataggaatg atacaacaaa ataagacata gatttttccc ctaaatattc tgtaatgcaa
76741 ctgggcacac aaaataaata tgcagaaaaa atatataagc aattcaaatg taaaacagca
76801 atatagttat aagtaaggag taggatggat gagagtaggt ttgataattg ggaatacagg
76861 tgttcctcaa cttatgatgg ggttatatct gagtaaatct atcatgagtg gcaaatatca
76921 taatggaaag tgcatttaac acacctagcc tactgaacat catagcttag cctagctgac
76981 attaaatgtg ctcagaactc ttacactatt ctacagctgg gcaaaatcat ctaacagaat
77041 acctcttttg taagaaaatg ctgaatatct tatgtaattt attgaatact gtactaaaaa
77101 tgaaaaagca gaatggtcgt atgggtactc aaagtatagt ttccactcat atgtatcact
77161 ttcacaccat tgtaaagtca aaaaattgta agctgaacca tcgtaagtta gggattatct
77221 attattagaa acataataat gtagagaaaa tgtcagagaa cacaaaatag aagagttaag
77281 agttcagtga ggatagagat tgtattagtc cattttcaca ctgcttataa agacataccc
77341 gagactgggc aatttacaaa agaacgagat ttaactggac ttacagttcc acatggctgg
77401 agaaggctca cagtcatggc agaaggcaag gagaagcaag tcacgtctta catggatggc
77461 agcaggcaaa gaaagaataa atgagacgaa aaagcagaaa cccctgatca aaccaccaga
77521 tttcctgaga cttattcact gccacgagaa cagtatgggg gaaaccaccc ctatgattca
77581 attatctccc actttgtccc tcccacaaca catggggatt atgggagtac aattcaagat
77641 gatatttggg tgggaacaca gagccaaagc atatcagaga ttaatgtgga ctcaaagagt
77701 tagggaagga gttatgagag gggatttaaa attgaactag tctaaagaat gatgagaact
77761 agacagcaaa aataagaggg atctggccca aaaataggaa ggaaagaatg agataagcac
77821 agtaagggac agtgagtaaa atgataacat gaaacaaatt gtgaagagtc cctctaggta
77881 aaattaggtg ttaagaatag acgagactaa agaaacttgg agagtagaag tctaaggcgt
77941 ttaatttaat gcaagaagca attactgtgg tttacaatgt ataacacaat ttctgtggtt
78001 tacaatatat aacacacaag agtagatggc atggcagatt aagagattag tagaacacag
78061 aatttctcac tctttaaaga aaattagaag aaccaatgtg atttttcccc cataggaaac
78121 agggactaat tgagaaaata tttcagcaag agaataattg gagatttgat aagtaacatg
78181 tttaaaagga ttactttact ttgactgcat gatttagcat gaattctagt gcgattacat
78241 gatgattaaa caaagaaaga taaaagcttg ggtaaaggat tcaatttgga ggaaaaatca
78301 attagctcca cacatgttga ttttctgatg acatccaaat tttcaagtgg aaatgttcat
78361 taatcattta gaaacataca aacggcattt aatggacaca tttgggttta acgtaaattt
78421 ttagaaatta tatatagaga ggtaatattt aaaaccataa taacagctta aagttgtata
78481 ttgggcataa tggatggtca taggaccgag cctaagagaa tctccccgga gacttaagga
78541 attattaaat aaggaattat tgaaggaaac aaagaattgc tcagtgatat ggaaaggact
78601 aagattattt taatattgca attaggagag tttcaagagt taaaggatcc caggtatcaa
78661 aaaagttagt gcagaaaagt agagcacatt gggataaaac acacatcgag tatttcctta
78721 ctatgctaaa aatttaggtg cttattccac tcctattttt tattatcatg gttagcagaa
78781 atagcaacgg atcagtgggt gttctgtttc attactagtc actatctttt attgcccacc
78841 tttctctgtg aaacaatagc tgatgctaag tctgacagga ctctttgtct ccacatatca
78901 aattcagacc ttccattagt gtctcaagtg tgtttgtcct cccataattg tgaattctat
78961 taaacaatct tacaataaaa tttacattga ctaggcagct gtcttcttca ataatagaag
79021 agaacatgtg ctgcagattc ctagacatgc tgactacaat ttgggactca gatttaaatt
79081 tactgtgctt tgaagagtag gcaaatatta gttgtcccag gtctcaatac ttctctttga
79141 ctgatacatc catctatcaa tacatttgca tatgcttctt tgtacaaggc ctaagatcct
79201 gtcagcaatc aataaacatg cattaaatcc tctttttccc tttaggtttg gggaatgtga
79261 gtcatacgct ttcccaggca tggaaaagga aaaatattag ctaacatttg gtggtacttt
79321 atcattcaca tacatttgtc atttggttgt tttgtgagat aactactgtc agactcagtt
79381 tattagtgag gaaactgagg actggagaag ctgaatgaca tctacatggg cattcagatg
79441 ataaataaat aagctggatg ggactccaac ctggggatct accttcacat ctgtagtctt
79501 atacataaaa gagcgattRc tccccagaga ctcttctgtt tattgctata acacagctta
79561 tacccacaag acacaaaaaa agtatttgga aagtgaaaaa agaaacggaa tatgttacta
79621 tataaagccc aagcattact acatatacga ttaaagcaac attaaatgac tcaaaactaa
79681 tttcataatg cattcactat atgggcataa cctatggaag tataatgtag gtatatgagc
79741 acacaacaca cacacacctc aagtgtaaaa cactttatac ttaaataact ccttaaaaag
79801 ttgttactct ggtgttacgt gctgtagttt ctgcagttgc cataagtcaa atcagttttc
79861 tgcagccgtt gacaactgtt tgagcagtga acagaaaggc atgcagcaaa catgtaaacc
79921 aatgtgtaat gtatagaggt tgtggagtgg ttttcttatt acagaaaagt gtactttcat
79981 atacaccttg tgaaggtgag cgtattattc atagttgaag ttattctatc ctaccatatc
80041 ccattttcaa attgtaaaca cttattcaat cactgcttca gaaatgcttc ccagttattt
80101 tggaacttat ttctgatttc aaggtaatgc actcagtatt gtttcagttc attctttact
80161 aaatcatcca aatgtttcag tagagaattt tgtttaccaa gaagcctcRg accctgtgta
80221 agttattttt taataatcgc tttagtttcc tctccaaagg cacaaatgac agaatgctta
80281 gaattataaa atatggtttc tctctctctc ttatttttaa ttttttagag agagggtagt
80341 catgagtttt ttacctaaac agtagcaagt ctgccccaat cttgtgaata ggcaatagtc
80401 ccttgtgaac tccatttgga atcagaacaa ataatgaaac aaaataatag ttaatgcttt
80461 gaatagataa ctttgtactg aacatattaa ttgacttgat cctcagttga gagctctctc
80521 actcactgtg ctgtactgct tctctcctga tccaaacagt aacctctcag ctcacctgac
80581 cagaatttaa gctttggaca tgatacacag aagcttagaa tatgtcagga aaacatgcca
80641 tatctgcaga tctgaacccc ctcaaagact tagcacatta agatattctg gtgccttttt
80701 gtatggtccc cattcttttg ggctgtataa tttttctcta aaatttctgc attacatttt
80761 aatagctttg ttgagataaa attcatatac catataattc atccatttaa aatgtacact
80821 tcaatggttt ttagtatagt tgcagagttg tgtaatcatc accaaaatct aattttagaa
80881 tatttttgtc acccaaaaag gaaacttaat acccattaag tagtcagtcc cacccagccc
80941 tcactgccaa gacaaccatg aatctacttt ccatccctac agattggcta ttccagacat
81001 tttatataat tggaattatg taatgtggtc tttttgtgac tggcttcttt tattttgtgt
81061 aaagttttca aggttcattc attttcagta aggttgattt ctatcaaaat tatgttataa
81121 ttacatatga ctttatttag caaaacagaa aaagatacag attcaactga tagtgtaaat
81181 gcaatttctt tctactacct gtctattttc attataaatc aatgctggaa ggaaatcttc
81241 aactaaaact tcaagtcccc aaactacact tctagtcaca aaaatgtgcc taaattatca
81301 gactaggaac acccccatga gagaaagtgg ctaaatgggg tatcttcctg aatgggcagg
81361 ccacctctta cctgggtatt ggacaaggcc cctactccag acgattaatc ctccttccca
81421 ccacaggctc actctttgca ttcttaggca gttatgactc tgtaaaaatg caaaagtttc
81481 taatgcttca gttgcggtta gctttttgta gttaaaattt tagtaatcag ttcataggct
81541 aaagctttgc taatcaaagt ctgatttatt gattagcaat atagtataac cagtgaactt
81601 ctttgaaaat agaatctcaa gactacctca gacctgccta taattagcat tttaagattt
81661 ccagatgatt catatgcata ttcaaattta agaaccctcc cctaaagagt attagaagaa
81721 attagattta aaagagatat ctgaggaaga taaatagaaa caatgaatga atgaatgaat
81781 gaatagaaag atgtagcttt catttgtttt gctttacaat ttgcttttgg ttggtactga
81841 tttaagtgct ttagtaacta ttaaagtggc attcagggct cattctagag cccaggatca
81901 taatcactca ttgtgcacaa tatatgccta gtacttcaca cattgtgggt gctctaaatg
81961 tatgttatct ctcttttcct ttctaagata taaaatttca tagtagtagt attaaaataa
82021 gaagaaagtt ataatgcaat ggaactacaa cacaataatt ataacgtaat aaataaccca
82081 attgaaaaat gggctgagaa agaggcagag caaaatagct gaaatgaact ccccagcaat
82141 cgtcccctta acgccccaca ggataaccga gttgaacaac tgcccaggca agaaagcacc
82201 ttcataataa ccaaaaatca ggtgatgatc acagtgcctg gttttaacat caagaaaaga
82261 ggcactgaag gctgggtgcg gtggctcacg cctgtaatcc caccactttg ggaggccgag
82321 atgggctgtt cacgaggtca ggagatcaag accatcctgg ctaacacggt gaaaccccgt
82381 ctctactaaa aatacaaaaa attagctggg cgtggtggca ggtgcctgta gtcccagcta
82441 ctcaggaggc tgaggcagga gaatggtgcg aacctgggag gcggagcttg cagtgagcag
82581 agatcgtgcc actgcactcc agtctaggtg acagagcgaa actccatctc aaaaaaaaaa
82561 taaaataaaa taaaaaagga aagaagcact gaagagggtg ggaaagacag tcctgcatta
82621 cctaaactct tccccacctc cccactagtg gcacagcatg geacagagag agaatccatg
82681 tgtctgggag agagagagag caaagtgatt gtcagacttt gcattggaac tcaatgatgg
82741 cctatcatag tgaaaaacaa tacagggcag aattctgcca gcccccatgg agggagcatt
82801 tagaccagcc tcagccagaa ggtaaccctc cactgcagca gtaggaacct gacttccagc
82861 tagctctacc attggttgac tacagtgctg gggtcctgaa aaaatttgaa agacaggcct
82921 cagggactac agtacttggg caagtactga tgctcttctg ggcttgcaac cagtggactt
82981 ggggtgcacg tgacccagtg agacaccagc ggtggtgacc aagggagtac ttgcatcacc
83041 catctcccaa ctctgtgcag tgcaacttgg ggagagactt cttttgcttg ggaacgggag
83101 aaggaagagt atagaggact ttgtcttgca acttgggtaa ccagctcagc tacagtaaac
83161 taaagcaact agcagactcc ggaagccctc tcctgattcc aggccctggc tactgaacag
83221 catttctaga cccaccctgg gacagaaggg aacccagtgc gctgaaggga aggacccagg
83281 cctggaagga ttcaccactt gctgattaaa gagccctcag gccttgaata aacatgagtg
83341 gtagccaaga aatagtcacc acaggctttg ggcaagaccc agtactatgc tgacttcagg
83401 tgtgacccag cgcagtctca gctataggaa agtaatttat cctcccttgg cctcaatttt
83461 ctagttttag aaagtggatt atactatcac ccacaataat agatgtgtgt gtgtgtgtgt
83521 gtgtgtgtgt aatgtcaata tatgtcaaat gcttagacac tacctagcac ataaacttta
83581 ggaaagttag ctctcatttt tatttgttct gttttgtttc tgattttact gttatatagt
83641 tgtaaagaaa aaatgtggta tcctaggtag ggtaaaacat taatgtacaa tttaacttag
83701 ggaaatttaa tgtccccatt atattgagtc ttctgtttca gagcaaattc tttccattta
83761 ttcaagtttc tttttcgatc tttcagcaga atattcttct cataaatttg ttaaaattta
83821 ttcccaggta ttttatcttt tcattgcaat gtgaatgaca ttttctagtt tgttatagtg
83881 tgtgtatcct ataaacacac tatataaaac atattaaaaa tcaagaaaca ttggttcttg
83941 atatttaagt ttaaatcatt aaacttactg atttgtttta tcatatggtt tagatgagtc
84001 ttttggaact tcctggttta caattaaatt ccaatatatg gtgataattt tgcttccctt
84061 ctgataatta aacatcttgt ttctcttttt cctaattgca gtggttgata ttttcagaac
84121 aattatcatt tttcaattga attatcattg tactcctgga atgaaacaca attggtcatg
84181 gtacattatt cccttagctt gctgctaaac ttgttttgct aatattcata agtgaggttg
84241 gcctatggtt ttcttttttg tattatggca ttagtttcca aggctgccaa taacaaatat
84301 cacagactga gtgaaatgta tctcactgta cattacagta gagttagatt agaacacaga
84361 gaccaagatg ccagacatgt gcacacacag agatatgacc atgtcatatc tgctactgct
84421 accatggccc atctgctact tatcacttgt tcatgtacaa ctatacattt ctgtacaaca
84481 gaaatatatt ttctcacagt tcagggcaat agaagttcat tatcaaggtg ttggcgaatt
84541 tgatttcctc tgaggcctct ctccttggtt tgcagatgca ttcgctgtat gttaacatgc
84601 tcatatctct gtgtgtgcac atgcctggca gcttggtctc tgtgttctaa tctactcttt
84661 ttatgaggtc acttgtcata ttaattaatg cctaccctaa tgaccttatt ttaacttaat
84721 tacttcttca aaggctctat ttgtaaatag tcacatcctg aggtattatg gggttagggc
84781 ttcaacacgt gaatttcagg ggacacaatt ccccatagca attatccttg tcagattttg
84841 aaataaatgt catgttgaat ctgtaaaaat aatttggaag cttttctctg tctctttctg
84901 tctctctctt tctctgaatc tgttatgtag cctgatgttg tttttatttc acacaatgca
84961 tcaatattac cttgtctctg ataagtctcc caaaatttca caggcagaga aacaagtcct
85021 gtttctgtag gagaccacca atatgcacat ctcagactac cataatttgg atatggaaaa
85081 catcgcaagg gccaaatatg ccagccgatg cacatcatta taaattattg tttcaatatc
85141 aatctaggga atgtcactaa tgattgatag gtattataat caccattcat tgtcattaac
85201 tttataggtt tccatacttg gtttttgtag tcatgtgcag ttccacaatg ccaaaacttg
85261 atataccttc attttaaaca gttaagtttc taaaagtaaa cctttctttt acacatagtc
85321 ttaaatatct aagactcaat ttaagaacac tgcatattct gtggcattcg aaaatggttt
85381 cctcgggagt tgaaaccata aactctatac cccattactg agtgtgccct atgttacaga
85441 atactcctta ttaaaggtga aaaagcaatc tactactctg caggcttttg gtctggagat
85501 aaacacaaga tcatagatca tgtattatta tcagttattt taaggtctca gagcaattct
85561 ttaaacatgt atcaattgta aggagtaata taaaaggacg ctagcttgtc aatttctttt
85621 tgtcactcag gtctttggca tagactctgt tagctttatt aaacattaag tattgctttc
85681 aggKtgaggt agaagagcat aagcaagaaa agctttatag gctaataaaa atgtaaatga
85741 gatgttcatc agcttgctgc cctggaaaat gatggaagaa acattacctg aaaaattaga
85801 ttcaacRatt attgctaacc aaatcaacct gatatgagaa atccctttgt aaccatttgt
85861 gttaatttgc atccttatgt caatctttct atgcactgaa tttgcttcca acatcctagg
85921 tcctctRtac atatatatgt agataatgta tatacacatt tttatatata catagaaata
85981 tatacacata tttgtataat tcatgttatt aattaacatg tattagctaa acagaaatat
86041 ttctgttaca tatttgcagc agttggtaag aaacgcctat atattttaat tcgtctgcac
86101 ttagccttct ttttgcacac catactcctt acaaggaatt tgaagactga gttgtaaatc
86161 agaatttcta tagcttgtta aagtcacatc ctcagagttt ggaaacctct gagctcacta
86221 tgtctcagga agacgggaaa ttcttcttct Wcttcttctt ccccttaatt aggaatacat
86281 tgtaataata atattttcta tgtgaccttt gaatacagta gtaaaataac aagtgggggc
86341 tacttacttt tctcagggat gattcatcct gggatggtgt ttagacagtg gcctttgagt
86401 attggatatt ctataaacat cgtgtgagtt gttcttcttg atgactccct ttagtggatc
86461 tccgaagacc ctttagaagc ttgctgaggg tgggatggag gaagaggcta aagcccccat
86521 aactgactct cagcaactgt cctctctcac agaatctctc ttttgcggtg acccttaaag
86581 gcacttggcc catctgctac ttatcacttg ttcatgtaca actatacatt aggccaatat
86641 attaggttgg tacaaaaata aatgtggttt ttgccattat ttttaatcta aaaaacctgc
86701 aattactttt gcacaaacct aatagttatt gtaaaggatg gaacttttaa gcaaggcaca
86761 caaaaccttc taaagtcact ctgagaagca attcagagta gccccttgct gcatctttca
86821 ttttgcagcc attttactct tttctctgcc ctaaagcaga tctcaggtta ctaactaacc
86881 catttatgcc agaggttgca catttttttg tgtgaaaaat cagaccttgg cgatgacctt
86941 gagaagtagg atataaataa ctcccacaag cttagcgttc caataatgga acactaggca
87001 taaatgggct aactccttca gctctgggct gagtttctca caattactgc agatctccac
87061 atctgggcag gtcctgacaa tagttaaaga ttttttttct cataatttgt cctgaaagga
87121 catatattga gctattcagg agacttgaga aaagttccaa gttaaatagg ataaagggca
87181 atggatacac attttttgtt cagaaatata aagattattc ttagttagag gtgaatatgt
87241 tccttcactg ttctctgaat tcattctgtc attctgctcc tggacttcct acaatagtac
87301 cttgacttat aaggcccgtg tccagatctt ttacagtcca cttcattcaa aatgctcctg
87361 aaaaattcaa gggactcact aacacatggc tttggtaaag gcattctcct gaacaaaaac
87421 ctttctgacc tcaaaatMca cctagcaagg gatttagtgg tgataatcta gctctcctac
87481 cttttcagcc ctggatcttt atgctcttta tcttgcaaaa catgctctaa attaaattaa
87541 ctgctaccca tttgtatgcc ccgtgtttct acaacactat agtctcttta tggttcacct
87601 tttctaccca tccccaaagc ccagatgaaa tgccactttc atgaaactgt tggatccatc
87661 tatcctgaag tttttctatg ctctgaacaa ccacaatgtt tttttgtacc tttctaataa
87721 catgtaacac cacctgtttc atgagcatag ttttatttga ttattttatt atactctttt
87781 ttgagcacag gaactgcaca ctagaaatca tcatatttct cacaggttcc aatattgtga
87841 tttttgcata cagtagattt ttaataagtt tctgtcaaat gactaaacta ataattattc
87901 aagtgtttta ggaattaaac agaatgagga aaattatttc tactctccat aaaagcagaa
87961 gagattataa tgatacgttt catgaagaaa gtagcttaca aaattacaag caattttcat
88021 gaataacttc aaacaaatta gtcttaatac ctataaaaag tatcacagcc ttaaaaaaat
88081 gatgacaatt aagtgatgtc agcagtatgg cagaataggt gtttccattg cttgtcatct
88141 cacagaaata tcaacttgaa gaactatcca cacataaaaa taccttcaca agagctaaga
88201 aattcagatg agagattatg gcatctgaat ggagcagaga aatcagcaaa gacacattga
88261 agaggacaag aatagtttta cattatgcat gtcacccttt cctaaagcct atgcagttca
88321 gtacaaatag agatagcctc catgtaaagg aaaagaataa agtgagtccc taacttcatt
88381 gcaggcccca gcaccatgcc taccccagtg gattccagaa ccaggccagt cctcatgtcc
88441 ccagacctct ctctggcccc catggaccca gcatccaggc ccatgtcgct gccaaactag
88501 cccctgtagc ctgtggcctc aggcctcagg ctcattctaa tatcagacca gccctcacag
88561 ctccaggcct gctctgggcc accccagtgc caggaaggcc cccataagtc aggctgcagg
88621 ccagccctag tagtcccagg ctactaggga ctagagttca tgtaagccct cctacatgaa
88681 ctcaggtacg aggctcattc atatggaccc aatgtccagg ccctccccag tagacccagg
88741 ctccaggctt gcccctacaa aaaaagacat cagattgacc cctgtggact taggcactag
88801 gcccatgaac ccactgacct aggcagcagg ccagcctgcc tgaggactcc cgtggcaagc
88861 ccactgcaaa ccccaatgga taacctggtc agaatctctg gacaagctgt ctggtgaagg
88921 gctttccttg ccagtctgta aagactggaa gaagtgtcta cttcaaatgc acagatacca
88981 atacaaggcc acaaggatca caaataatta gggaaacatg atgctaccca ggaaacaaag
89041 caccaggaac tgaccctaag gaaatgaaga tttctgaact gcctggcaaa taattaaaaa
89101 taatcacctt aaagaggctc aatgtgctcc aagagaacac agatatcaga agttcaacaa
89161 agaggtagaa accataaaaa gaaatcaatc agaaactcag aagctaaaga gcacaatgat
89221 tgaactaaaa aatttcacag agaacttcaa cacaaacttg atcaagcaga agagagaatc
89281 agcaagaaaa aaaagaaact aaggaaaaaa acaggtcatt tgaaattact cagataaaca
89341 aaaaggagaa aaagaatgac aaacgtggaa aagcctacag cacttttggt acatcaacaa
89401 gtaaaccagt gtatgcatta ttgaggtcca agaagaaaca gagaaagaga aaggggaaga
89461 aagcttattg aaagatatca tgacagaaaa cttttcaagt ttggaaaggg aaatgaatat
89521 ccttatccat gaagcccaaa gaaccccaaa gatacagaga tattcactga gacacatcat
89581 aattaaattc tcagaaatca aagacagaga aagaattttg aaagcaccat gagaaaagtg
89641 actcatcaca tatataaggg tataagaata tttattcaac aaaggtggca ggaacacaca
89701 ataggaacag gacattctct tcaataaatg atactgagac aaatcaactc aaaattgact
89761 aaagacttaa atgttaaggg ctgaaacttt aaaactacta gaagaaaaca tagagaaaag
89821 cctttttgaa attggtttgg gcaatgattt cttggctatg acctcaaaaa cacaagaaac
89881 aaagcaaaaa gagattaaca ggattgcatc aaactaaaaa gcattggcat agcaaaagaa
89941 acaatcaaca gaataaagag acaacttatg aaatgggagg aaatatttgc aaaccataca
90001 tctgataagg ggttaatact cgaaatatat aaggaattca actcagcaac tcagtaaaag
90061 gacaacaaat attccaatct aaaaatgtgc aaaaaacctg aaaagacatt tctcaaaaat
90121 aggaaataca aatcgccaag aagtatatga aaaaaatgct taatatcgtt aattatcagg
90181 gaaatgcaaa ttaaaactac aatgagatat taccccatac cattataaaa tggctactat
90241 caaaaaggca aaaaatagca agtattgaca agaatatgca gaaaagtgaa acggtacagc
90301 agttatggaa aagagtataa agattcctca aaaaattcaa aatatgacta ccatgtgatc
90361 caacaacctc atttctgggt atatattcaa aagaattaaa atcagcatat tgaagatata
90421 tctgcattcc cattttttaa aaatggtgtc tcattctatt gctctctcat tcgtattgca
90481 acattattca caatagccaa gatgtgaaat caaccaatca acctaagtgt ccatctattt
90541 atgaatggat aaagaaaatg tgggtataga atagtataca tatcatatat gtgaatatta
90601 tttatcttaa aatgaagaaa attctctcat ttgcagcaac atgaatgaac tgggaggaca
90661 ttatgccaag tgaaataagc taggcacaga aagacaaatg cttcatgatc tcacttacat
90721 gtaaaatctt aaagccttaa aattacagaa gcagagagta gaatggtggt tgccgggggc
90781 tggatgtgaa gaaacaggga tgcgttggtc aaaggatacg aagttttagt tatgaagaat
90841 gaataaattc tggagatcta atgtacaatg tagtgtttat aattattaat attatgttgt
90901 atactttaaa tttgctaaga gagtaaatct taaatgttct taccacaaaa atttaactat
90961 gtgaggtgat ggatatgatc attaggttgg ttgtggtaat cacttcacaa tgtatatata
91021 aatcagtcaa agcatcatgt tgcacaaaat aaatacatac tttttatttg tcagttatac
91081 ctcaataaag gtggaaaaat aaatttttaa acactgaata taggtaaagc taaaagttat
91141 atgtggggat atggggaaag agtgtatgtt gtggcttgga gcaacaagta aaaggattac
91201 atcttcatct tccacatagt gtggttaaac agaaaaaaaa taaatattaa aaaaatcaat
91261 tatttttaca ttgtgtatat aaatatccaa agaagcagct aaattagtca aagtgcttat
91321 ctttgggaaa taataatgga aggagaagta aaccagagaa ctttgttttt caaagttgac
91381 cttgtagaac catttttgac ttaaaaaatg gatatatgct gttttgattt ttaaaaatta
91441 attaaaaaat gatgatcaca ttttgtcttt aaaaattttt gtttaaaacg tatccatttc
91501 ttctccccat ttaatatatc ttttgaccat ttaaagtata aaaaaagaat ttggacttaa
91561 tctaatgaag aagtttgacc ctaacaaaag agagtaatgg ggtttaaatt tatgccactc
91621 tacaaaaaag aagtcgaact cacccatagg tagtgtcatt agtcttttag gtctgcatgc
91681 ctctctctat gacttttccc aatctttgtt ttaatcaata atcttgtctc cagtctaaca
91741 tgggaattgt gctctctggc ataaaatggg ctactgaatt acagtcctgt gctatatcac
91801 acagccttgc cattgatagc atggaaatac ttcgaaatac tgctgtcaaa atttgcaaac
91861 tgtcaagata aataagttca ttcagattat ttatatctgc tgtttctccc cctaacctca
91921 tacttagaaa attatatgtg tctagtcctt ctccaacttg attttatgtc ttttagccta
91981 atacattggc aaaccaaatg catgactctg acaccgataa tactaagaag ggctgaaatg
92041 aattgttaga atgagagaca gtcactttgt ttagaaggga gtgctccatg agcagtgtga
92101 taacatagct ccttgaaaat ctagtcaatc accattttat agtaaaagcc tatgaatttt
92161 tgtagcttgg tgtcttattg tctctattca atagttgctt ctaacttttc tgggcatccc
92221 cagaaaagtg gaaacctcct gtgaatgagg caaatttagt aacctccaat taatcaagca
92281 cactaagcac ataccacatc tgcaggaata aactaggtat gggattaaag agatgtatag
92341 aattaattct ttgcttaatg tattttgcca ttctatattt cttttttttt tttcaagaga
92401 gcaagtctaa gtcctccctg gagaattgtt gaaataatgc ctaatttagg taactaagca
92461 ttttaagcct ttctacactt ttataatatt tgtaattgaa aaaaacccag caccaatata
92521 taaataatta atttaccttt gaaatactgc tgtcagaatt atgatgcaaa ctctgcatca
92581 catttttgca taccttttaa cccaggaaat tcacttctag aaatttattt tacgaaaata
92641 ataagagatt gaattgcatg ggtgttcatg caaaataaaa aagtaaaatg ctctaaatgc
92701 ccagcattaa atattgatta aatcaaaaca gtgcatggat atggtgggac actatgctat
92761 cattaaacat gacattgtac aagattatac attgacatga aaagacacat ataaagactt
92821 tgtgaaacat gtataatgtt atttaagctt tgttgtgaca ctcaagtttt ttctttcttt
92881 ttagtttttc ttattactag aatgaatgca ttttcttaaa tattcacctt tacagaagtg
92941 actacacaat taatggctac acacctctcc ccacttattt ctgcccaaag acaactactg
93001 ttgacatttt ggtggatatt ctcctaggtt gtttcatgta tgtctttttc aaatgtagga
93061 tcacactaaa tgcttctgaa gcatactttt cttatttaaa aaatacagca gacagcttct
93121 aagtgtgcac catgttcttt tgtaaacata tgtattttaa atatatgcac acacataaag
93181 agagagaaag aggctgttta aggagtaatt gttaagtgga tatgcatgca acgaccacca
93241 gtttaagaag taatttctag ttccccggag aatcttcatg agaacttctg atttcatatc
93301 tgtctccttc ttctagagta atccctctct ctctatggta actattcctt tgctttccta
93361 gatattaagt atatgtaaat gtatgtgtaa ctctgtgaat atgtatctct gtataaaatc
93421 attaattaaa tatttttaat tttttctgtt cttgaacttt atgtaaatga aatcaaaggc
93481 atatttttgt gactttatta tttattgtga cttctttgtg agtgatcact tatgacattt
93541 taacaatttt tttatgcatg tggctgttac atagccacat aatatatgtt tacataggtc
93601 ttatgtacaa gggaaggttc taagcacatt atacagatta tcttgtttta tgtcgggaat
93661 aggtatcatt attcgtttca ttttacagat tgggaaactg agttccagaa aggttaaata
93721 acttaatgta ggtcacacag ctagtaagtg gtgtagatta tattctatcc taagttgact
93781 gacttcatag tctgtgatct taaccatagt tccaacctgc tttctgttac agatgagtat
93841 gctacagatg ccttctgctt atttagggtt aatgctttca tatattaaga atcccccaag
93901 actcaatttc ataaagatat tttaaattat tatcttaagg tttgatggtt tgccttcagt
93961 atttaagtgc tttacctacc taatattgat tccagtctat ggtacaaagc atgggtttaa
94021 cttaattttt tgacatgttc aattgtctca acacctttta ttaaaaagct tatattttcc
94081 ttattaataa tatacaatac taattctgtc atatatcaag tgtccattta attgcaaatc
94141 tgtttctaga tctctgttct gttcatttat ctacttatct agtcatgcaa catcctatat
94201 aaagttgttc agaatagtct cttaataatt ttaattttct accaatagtg gcatattctt
94261 ttttattcct gatactgatt attttggtct ctctttttgt cggtcttatc agaaatcaga
94321 agtttagcaa ttttgtgtct ttgcaaagaa ccaacttctg gctttgttga atttctctag
94381 tattatatgt ttgtcttttt tttaatcaat ttctgctttt atctttctta acttcatata
94441 atttcactac tgtttttcta atttcttaag atggatgcat agcttagctt attaatattt
94501 agcctttttt ttctaacagc attttaggct acacatttgt aagttctgtt tttggcacat
94561 ttaagttgta atatattttg ttactgttca gtttaaaaca tttttccttc tactagaaat
94621 tctttttgga cccataaatt atttagaagt aggtttccaa ctttacaaac ttagtgtttt
94681 taaattacct tgatattgat ttttaagtta gttgtactgt aagcaaagaa cttcgtcatt
94741 agttttccag tatttgaaat gcattgagtg ctgctgtaag ggccaatatt tagtcaattt
94801 tgtgaatgtt ccctttattc ttgaagtgaa tatgcattct gcagttgttt gctacacagc
94861 ttataggtac aaatttgatc aaggtcttaa ttgtgtcctt catgtctttc atatctttat
94921 tgtttcttgt tggctttatc aattttgtgt taaaaatttt tcaccatgat tgtagatctt
94981 gctgtttatt gttgtagttc tataaggttt tgcctaatat attttgatgY tatgtgttat
95041 tgatataaaa tttaacatgg tttatagttt cccagggtga attaatgaat acattacaat
95101 agattgaact tctctatctc tagcaatggt ttactttacc catgaagtcc aatttttccc
95161 ttatcaattt aataatatgt gactttattg cttagaattt attggacata tctttttcta
95221 tactgttatt ttaagacttc ataactgttt tactttaaag gcattttgta aatggcatat
95281 aattgaattt tattctaccc tagacagata ttcttttgcc tgaaagatta attcactttt
95341 attagatatt attacttaca tatttggagt tgaatctacc aacgtatttt gtatttccat
95401 ttgctccatc ttgtcttacg tcaaatatta agtgcctgta tatgtgatga tctgtttcta
95461 gactctatat taacctactg ttctatttgt ttgttgtatg tgagtaccac tgtgttttcc
95521 ttgctgaagc tttacaatga gttttgacat ccaagcatat gaatgtaata atcttcttct
95581 ttaagatttt ctttgttact ttttcgcttt ttacatttta ttatatatta aaatcagatt
95641 ggtaattctg tgatttttga tagaactatt ttttaaattt aaattaaaat tttcatttgt
95701 ttcttgttgc taatgaataa aaatataatt tttgtacact ggccttgttt ctagtgattt
95761 tgtttaattc acattttaat gatttatatt taccatggga atgattcgat tgcaaataga
95821 ttcttctgtc cttagttttc tatttctttt tctttcctta tttcattggc actctagaac
95881 aatgtcaaac agaaatggtg acaaagaata gacctgtttt attcctgatt ttagggataa
95941 aattatattt cagcattagc tatagagttt ctataatttt gtgattattt tctaagtatg
96001 tatagacatt tttatcacat taagaatttt ttccttctat tgtttgctaa gaatttagtc
96061 cacaattact attaacatta aattgttatc aaatattttc tcatctattg agatcattat
96121 gtaattttct tctattattt cattaatatg ctaatttaca ttggttttga atgccaaatt
96181 aattttggat tcctaacata agttgcactt tttctgacat gtcattttta tactcgttga
96241 attcagattg ttgatgtttt tattttttaa tttacaaata aaaattatat atatttatgg
96301 tgtacaacat gatgttttga tagattcttg atattttctt tagaattttt gcaactgtat
96361 ttgaaagaca ttgtcctata atttattttc tcataatgtt agaaaaccct ggcctcatag
96421 aacaaattag aaagttctat tctttggaaa agtttgtgaa gatttatgtt atttcctcca
96481 taaatattta ataacattat ctagtaaatt tatetaggat atgggttttc tttctggaaa
96541 tgtgttcaaa ttatgaattt gatattttca gaagatatgg atagtggttt gtgggaatct
96601 gttgatactg acactggctc agggtgcatt ttgcacacct ctttctaact ctctcctcag
96661 tgatgtcatg caagtagctt aaaattagcc attgtggaaa tatttacaac acaaaaatca
96721 aaaaaagtgt ggcttatttt ttgagagctg aaggaaaact taaatgtttt cacttcttcc
96781 tatgttcatt ttttaaagtt gtgatttcca aggcatttga ttatttcacc caaatctcca
96841 aatttattgg cataaatttg atcataagtg cttcattata tttaatgatc tgcaataatg
96901 atctttttca ttactaatat tatgtatttg ttccttctca atatttttcc tcaggtatct
96961 ggtcagaaat ttttcaattt gtaattattg tttgtttaaa aaccttttgt gcttttgtta
97021 tcttctctat tttttttact caatttcatt gttttcttct ttttaactgt ttcttttagt
97081 tttctgggga aaatataact tggaattttt tctaacttct taagatgaat tattagatta
97141 tttattttca tccttttttt attgtttaat atttRcattt aagactatag tttttcattt
97201 aaatacaggg ttagtggtat acctgaattt ttatatattt acacactcat tcacttcaaa
97261 tattttcaga tttccattat tatttgtctc atgggtcatt tattttttca ttgctaaatt
97321 ttcaaacatt ttgacagtta ctaattattt ttttactttg atttgcagta taattgcatt
97381 atgctcagaa attatagttt

Following is a PCLO genomic nucleotide sequence (SEQ ID NO: 6).

>7:82022801-82112500
1     agttgcctcc ctttgccccc ccacccccca acaggccctg atgtgtgttg ttcccctctc
61    tgtgtccatg tgttctcaat gagtaactgc catttctgct aatgcatgta attacatttg
121   tgttcttatg atatatattg gttttcatcc agggttcctg gtttataact cccacagccc
181   ttattacagt cttttgttac aatgttgggt gtgtgaggcy tcaggggcag gcctcaggaa
241   atagaatctc tctcctgccc tcctttcagc tgccccaagg cagaactcta atcttctccc
301   acctttctga tgtgagtctt aagaccctcc ccagggaagg tcccaccctg tactctgtgg
361   gaagaaatgt tgacatcatg aagcttccat aaaaacccaa gaggattggg tttgaggagc
421   ttctggagag ctgaacacat ggaggttcct ggagggtggc atgcccaggg tgggcatgga
481   agcttctcgc cccttccccc ataccttgcc ctgcacatct cttcatctgt gtccttgata
541   gtaaacctgt aaacataagg tttccctgag ttctgtgaat tgtttcagca aattaatcat
601   acccacagag gagatcacag gaaccccaac ttgaagccag tcggtcagaa ctttctaagg
661   cccagacttg tgacaatact tgtgtgtatt gggaggcagt cttggggact gagcccttga
721   cctgtgggtt ctgacactag ctccaagtag atagtgctgg aattaaattg gaggacaccc
781   agctggtatc tgtaatttgg tgtgtgggga aaacagcccc ctaacctctg acgtttggtc
841   acagaaatct ctgttgcttg ttgtggtgtg agaattgtgg aaaaacatga tttgaggaga
901   ggtttcttga aataacattc ccttcctttt ccagaaaaaa atcttctata cataaatgct
961   cagttacagc atgcaaacta ctaataattt atttcattat tttcatttat tttgcttaaa
1021  tcacagggac tggctatgtc tgttttagag gactgatttt acagtgcatc caatattgta
1081  aatctactgt ggcaacatat gcttagccag aagaagtcga aagagaagag agtagaatgt
1141  tctattctgg aaatagtttt catgtcacat ataaaaatga tatactaaat gaattatgta
1201  taaattctaa atgagctttg aaactttttt acgttaatat aaaatagtat agaatatcaa
1261  aatccatttc agaaatttac tacggttcac tgttatgttt ttcatttcaa gcaaaactct
1321  tctaaagttt ccataatata aatatatttg aaagtgtctt atatRttagt atatacagag
1381  atgccttaac acaatctctt attttatctg tctagtatct tttctcctct ttcaccacta
1441  tctcaagaac atctactccc aaatgcatat ggttctctta agctggaaac caccatactc
1501  aattttcttt gtcacgatgt ttgttccagg taagtgcatc tgacccacat aggaaaaacc
1561  agagtgcttc actgaggatg ttagacatat tttctccttt gggtcaagag tgtaaaacta
1621  ggcctcaaag gagccagcaa cttcatccct tgccttatag aacaacctga gaaaaggcca
1681  actttcagag aaaagctgag aaaagatgtg agaactaaac aggcttgagg ctggtctttc
1741  ctgagactat gatatctaca tgtgaatttc ttagtatggc caccagtaaa cattctttgg
1801  ttttgagttt gtttgtgtag ttttccatct cttaccagtg aaaatactgc cttatcttag
1861  agttaaagaa atatcacatt taaaaattgc accctagagg gccgggtgtg gtggcttacg
1921  cctgtaatcc cagccctttg ggaggccgag gcgagcggat cacgacgtca ggagatcgag
1981  accatcccgg ctaacacggt gaagccccgt ctccactaaa aatacattaa aaaagaaaat
2041  tagccgggca tggtggcggg ctcctgtagt gccagctact caggaggctg aggcaggaga
2101  atggcgtgaa cccgggaggc ggagcttgca gtgagctgag atcgcaccac tgaactccag
2161  cctgggcgat agagcgagac tcggtctcaa aaccaaccaa ccaaacaaaa attgcaccct
2221  agatgtaatg aaaaatttaa tgaatgttaa aattattcaa tattgttttt aaattaatta
2281  aaaataattt aggcataaga gaacataaag aatatatcat aagaactcat gcaatggctg
2341  gtcagcttaa gaaatcaaac aaattcagat gaagccaata gggtaatcct ttcccaattg
2401  cttctctctc tcttacccct gaagtaatca ttattaactt gattattata attaccttgt
2461  tattttaatt atatataatt atatatgtat agttatatgt attacatgta tgtatatata
2521  gacacataca tacatgaatc cggaagaaat aggcaaattc ttagcccttc tcactgtatt
2581  aaatgataaa cctgatacag acatcatcat ttctttcctg aataattgca acaaatattc
2641  ggaggtcttt cttctttgac cctttttctc ttcagaatat tctcagaaga gtaattagga
2701  tcatcctttt aaaacttgag ccagactgtt tcattcctca cctcaaaacc ctccaatact
2761  gtcccacacc atgttgtgag agttcttgca gtgttcaaca aggcttctat tctctctctg
2821  acctcatcac ctaccattct ctccactgct cacttcacct gggtcatact cttcctgaag
2881  gtgctgggca cacttctgct ggtcagccgg gaacgttatt tgtaggattc acacagctct
2941  ctccctcatt ttcttcagtg attacccaaa tgtcattttc ttgtgaggcc tttccggata
3001  atattatttc caagattttt tttctttttt aattgcagat gcccagaatt gaattgcccg
3061  tattcatcaa ttcacagcac acaaccacac aattaacatc tgtctctgcc agaacctgta
3121  tttgtttggt actttgttta gtttatattt ttccctttta tcttcctaac tttatcatcc
3181  tcattaccct cccaaccaaa ggcaaccagt cttgagtatt tactgtattt cttttcaatt
3241  caacttctat gtatttgttt acatgaatgt ttacaaaaag gtatatctgt gagaatgtct
3301  agtttggctt tctatctatt tattctgaac taaaataata tcatgctgtg aatctcatta
3361  tttgtactca tttatttctc aaatctatat ttttgaaatc tattgatttt attatatgta
3421  gatctagata atttttttct gacagttgca tggtattcca ttacctgcct ataatatatt
3481  ttatgtatct gttcctctag ttatggagaa ataaatatat tgcctccagc tttttacaac
3541  cacaaaaaac tggaaaacat ttctttacta atgcctttgt aaatgtttac ttaccaaata
3601  atttaagttt ctttggtatt attttatatt tcattttttc ctttagcatc acaaaacaat
3661  tattctttat tattccagga cagtggtcct caaccttttt ggcagtagag actggttttg
3721  tggaagacaa ttattccatg gattgggggc tgtgggggat ggtttcagga tgaaactgtt
3781  tcatctcaga tcatcaggca ttagattctc ataaggagca cacaacctag atccatcaca
3841  tgcgcagttc acaataggat ttgcattcct aagagaatct aatgccactg ctgatctgac
3901  aggacgcaga actcaggagg tgatgctcgc ttggctgcca ctcacctcct actgtgtggc
3961  ctggtttcta acaggccaca gaccaataca ggtctgtggt cctagggttg gggacccctg
4021  tactagaaga aataaagctt tcaaagttat aagctaagaa attattctat atatttctat
4081  agcccactat cttcccatct cccaatcatt tcagctcata gttttgcaaa agagatagaa
4141  cttaaaaaga tcattacaat tacagggtga ttggcgcaat gatggaggca ctgacaggag
4201  caagagaaaa cttccttaac agagccagat ggagagcgcc cacagatagg ttcttgaaaa
4261  agtaagctga ggggtgggtc tcaaaggatg aaaaggtgtt ttccaggatc aagcattttg
4321  ggaatgggtg atcatattaa gcaaagagaa cagcaggagc aaacttaaca agagaaactg
4381  cagagcctgt gtggaagact caacacaatt ttgatataac cagatgtaaa ttgggagaaa
4441  ggacatgtca ggagataaac tggagaagta gaaagagggg ctggttgtgg taaaacctag
4501  ctagagttat atggttcatg aggtccacag aaatatttta tgctagagag tgacaaagtc
4561  agattagata gtggctgtaa aagagatgtg aagatgatga taattcatct tcaaaaactt
4621  ctaaggtaga ttaggagatc agtgtggaca ctaggcattt cttttggtga aatgtgatgg
4681  aaacctaaag ttaggcagta gttagaatga aaaaaaggaa agagatttaa gaaatcctga
4741  agaggtaaaa tctgcaagga tttggcaatt gcctaaccgt ggaaatgaga cagtgattag
4801  aagaataatg taactaaaac caaacctgag atataaaata caggaggaga agaaatttac
4861  aggttaagag ccatagtatt ttcttctatc ctctagcaaa acaaacaaac aaaactacaa
4921  tctgatatat ttttctatac caataaattt gcatatttag agttttaaat cttaaaagtt
4981  tgtttaaatc gttaacaaat tattcttaat tagttaaaca attatgttta aggaacataa
5041  aattgtatat ttccatatct ccatattatc atgtttgcca ttacaacaat tcaacctaga
5101  ttgattctag atcgtatttt gcaaaatgaa taattagtga ctcattaatt aataaagaca
5161  caactttttg ttttgatact ttaagttctg aggtacatgt gcagagcatg caggtttgtt
5221  ataggtatac acgtgccatg gtggtttgct gcactcatca acctgtcatc tacattaggt
5281  atttctccta atgctatccc tcccctagct ccccaccccc caacaggccc tggtgtgtga
5341  tgttctccac cctgtgtaca tgtgttctca ttgttcatct cccacttatg agtgagaaca
5401  tacggtgttt ggttttctgt ccttgtgtta gtttgctgag aatcatggtt tccagcttca
5461  tccatgtccc tgcaaaggac atgaactcat ccttttttat ggctgtatag tattccatgg
5521  tgtatatgtg ccacgttttc tttatccagt ctatcactga taggcgtttg ggttggttcc
5581  aagtcttttc tattgtgaac acacaataaa catacgtgtg catgtgtctt tataggagaa
5641  tgatttataa ttctttgggt atatacccag taatgggatt gctgggtcaa atggtatttc
5701  tagttctaga tccttgagga ataaccacac tgtcttccac aatggttgaa ctaatttaca
5761  ctcccaccaa gactgtaaaa gcattcctac ttctccaYat cctctccagc atctgttgtt
5821  tcctgacttt ttaatgatag ccattctaac tggcatgaga tggtatctca ttgtggtttt
5881  gatttacatt tctctaatga ccagtgatga tgagtttttc ttcatgtgtt tattggctgc
5941  ataaatatct tcttttgaga agaagacaca acttttaaaa gcaggttttt aaataactca
6001  ataatttcat ctcattctat tgttttaacc catgccacaa ttatttattt ccaggagcgt
6061  tttagtagaa tattttattt aaaatatatt taaatacttt attaagaaaa ctatgaacaa
6121  gaaaatgatt aactttagtt ctacaaaagt ttaaaatatc acatgacgtg ctagacaaat
6181  ctcaatctga gactgctaat ccatgttcct aaagtcattg gaaaatgaca ttctggaaat
6241  agatcatatt cagagctcta aaacacccat aaaccaatga gcaacagctc atattaattt
6301  tactcagata aactcacggc tgactattta aaaaaaccct gtaaattggc tgaggaataa
6361  cacagcagtc tcaacatcaa actaaattgc aaaatttgac ctaaattttg acctagccaa
6421  gtcatcatta attaaaagga aatgaactca aactatcaga ctatcaaaag taataaacac
6481  ttgaagaaaa agctgtcttg aaaataaatt gttgagaaat agttcctgtt catttggcct
6541  cttgcagtaa ctgaagtcat tataaactac cttttccacc aactaaaata gaagtcaaat
6601  agagcatgcc tctggttagc taaacaczaga accatagaat gtgaaatgga ctcaggcact
6661  tcagcactaa aagatggctt caaccaataa gtgtatttat ctgatttaat ttaatcaatc
6721  tgatttaaat ttataattta tatatttatg atttaaattt aatatatatt taatatataa
6781  ttaataatta tatataatat ataatttata tataattaat aatttatatt agtatataaa
6841  tttaatatat ataattgata tagttatgat ttaaacttaa taatctgatt taaaaagcat
6901  taatgaatga aataaatatt ttttaaaaac caaaataata actcagttaa ctgccttact
6961  ctagaagatg tagtattttg ataaattaca tttcttctgg ttcaagaaat tccttaatgt
7021  tctcagcgaa ctttgtgaaa tgcatatagc aacatttaag tcttcccaaa atagaattgt
7081  aatttctttt gattaagcct gcttttcata ccttatggta gcattctgaa tttctgatct
7141  ctttgtataa taccatagat gcataaaata aaaagtatta aactaattct cctactattt
7201  tcaggatatg cccaaaatgt tttaattaaa aacgtcaaat ccttcttcta gacttgtctg
7261  ccagagattt tctgccttta ctgagagtgc tccacacaca cactcacata ctaatcagaa
7321  tgtggaagag tcgaattgaa tcaattcttt aagtaacata aaattgtgta tttccataac
7381  acgtctccat gttatcatgt ttgccgttgt aacaattcaa cctagactga tactagataa
7441  tatttctgca aaataaatag tgactcatta attaataaag acaaatttta aaagcaggtt
7501  ttaaaataac tcaatcattc tatctcattc tgttctttta atctgtatca caattatttt
7561  caggaggatt ttagtggaat attttattta aaatatatct aaatacttta ttaagaaaac
7621  tatgaaaaaa aatgattagt tatataaaag tttaaaatat ataatgaaat gctagacaaa
7681  tctcaatctg agactgttaa tccatgttcc taaagtcaca atcctaaagt cacaagaaaa
7741  ccacattctg aaaatacata atattcagag ctctaaaaca cccataaatc aatgagcaac
7801  agctcatatt aattttactc agataagctt gcttgtaact gtaaaaaata gttgaatcaa
7861  ttagattgat tcaattagat tcttaaatcg aagaagcatc aattagaata acctaattga
7921  attagagtct tccatatttg aaacaacagg tcaatgtcat tatctatata aagctaagaa
7981  agcaaaatgt ggccaggcac agtggctcat gcctctaatc ccagcatttt gggagactga
8041  ggcgggtgga tcacctgagg tcaggagttt gagaccagcc tggccaacat ggtgaaaccc
8101  catctctact aaaaatacaa aagttaactg ggcgtggtgg caggcacctg taatccagct
8161  actcgggagg ctgaggcagg agaatcactt gaagctggaa ggtggaggtt gcagtgagtc
8221  gagatcgcac cactgcgctc cagcctgggc aataaagtga gattctgtct caaaaaaaga
8281  gagcaaaatg caaacattct acctaattca aactccaaat tactctttta actcatcttt
8341  aaagtactat attgtcttat aaagcatagt caatttattt cttcaaaatc ccgtgaaggt
8401  ttgcttttca tcatgttcga acagtttccc taacttttaa aatcagtttt tacattgccc
8461  tctgctgtta acatttcttt tctgtttaat ctttctaaat catacttgtg tttagtgatc
8521  attttacatg atgaccatta tcacatcatt tcatctttat gatgctggtg cccgaagctg
8581  ttttatttgc attttgattc tgaatcattt ttagaacaaa gaacctcatt tgtcttccta
8641  gatcactctc agagctgtct gtcctgcttt tcgcacctct gcccctgctt gcattccagt
8701  ccttatctat tgaattgcct ccaaacgagt cccccaactt cagataagat cctctctaac
8761  ccatccttca gaaccccaaa tctgtgtaat tttccttctt aaaatcaatc tatatcttcc
8821  aattgcctat ttacagtgtg gagtctaagt tcttcctgac agcttcagat atttcaYaat
8881  ttatctgaac tgtgactgct ctcaaatcct atcttgcact actccctcca gcgcagaact
8941  atgctacagt caggcaactt gtccacaagt tcaccaatat cacgtatttt ctcatgttgc
9001  aaaggctttg acaatgatgt ttccccatat tggaatcctt gccagcattc cttctactat
9061  gaatacatat tacttttatt tcaagaacta tttaaaaaaa tattcctgcc aggaaggctt
9121  ttcttatcct tcctacagca gagtacctta atattcaata tacattcaca tctgtcagaa
9181  ctctatgcca attgttcatg aacatgtttg tctgtcctac tacactggtt ctttttggca
9241  gagacactgc attaataatc ttctgtagat ccagctgcgc ttgtgaaaag agaagcacag
9301  tcaatataaa ttcagagtta ctatactttt aagtaaatta tgtagttttt aattgaagta
9361  ataatctctc tgagttcagt tttagggtgg taaactcctt aaaacctgta taacaacata
9421  caggattaac aagacttttc aaggtgtctt aggtatggca ggcatatgca aaaatctaat
9481  gttttaacac actctctcaa tgtttttgtg taaacattta tttcagtttc gcaattatgt
9541  tattaaggtt ggtttagcct ttggtttctc tgagttttta ttacttgatt caaacatatt
9601  tatcaagtgg gcactttgtg caagtccctg tgccagacac tgggaatagc ataaatacgg
9661  taatacctta ttataaagga ttcctgtgag aattgggttc accagatttt ttaaaggacc
9721  tagccaaatg cttggcaaat aaatgaaagt tgtgttgttg ttattgttat taaggggttt
9781  gtgtagattt ttttaaaaaa gatgaatcat caattagaat gaatataaat aatcattcaa
9841  tatgacaata tcataataat atgtgtaaga taaagccctg ctactgctac ttagcattcc
9901  ataacaccaa caatagttgt ctgggctcca gagtgcaatg taaattagag aaatcacaat
9961  ggtgtgctat ttcttggata agtgagcatc cactttggat gataacagcc taaaattgca
10021 tctgcttagt gcaggacaaa acatgacttg agtagatagc aagtcctttt tcaaagtaaa
10081 agatttaaac agaataatcc acctccacag tttttagtgg tacaaagcaa ataatagaat
10141 atattgatga ttttagagat tagcagtcaa catttaataa acaagctgtg ttgtgctttc
10201 ctcagagtct attatctcgt gtccatagta ctttcttatc tgtaaaactg gttccttaag
10261 ggaaagtaat acttggttga ccaagggctt cttttctgaa atgtgctggt cttttctttt
10321 tccagtttta cttttttact tacctataaa atattttctt atacagaaaa ttatgtaaac
10381 ttccaggatt ttctagatat aataaatttt aaaaaatttt cattaaagta ataaactaaa
10441 aggtgggaaa gtgaattatc ttcaataaat tttgtcattt ttaaaaattc tgaatttttt
10501 cttcctgaac atttataaat ttatttttaa actttcagtg aactggaaaa agaagttaaa
10561 agttaaaaac tttgaatttc atagactttt tttcctccag agattttgta ttttacatca
10621 tcaaagtcag gttttttaaa agtgaaaaaa actttctcta ttcaacaatg aagctatcag
10681 gaggtcttta atgagtgtgt cagataaaaa gagtacttaa ttgtaatacc tactactgaa
10741 gagttttaag agaatggata ttcataataa tttaggggaa tggtagaaaa ttatttactt
10801 caaataatac catttttttc ttcttattat tatgcagttt gattcctatt gcttgttttt
10861 catttcttca tataacaaaa ggttgaataa ttttatggct cttttttttt tttgacaagg
10921 tctcactctg tcatccaggc tggggtgcag tggcatgatc tcagctcact gtaacctctg
10981 cctcctgagc ccaagcgata ctccctcctc agcatcccaa gtagctggga ccacaggcat
11041 ggcgccacca cacccagcta attttcgtat tttttttaga gatggggttt tgtcatgttg
11101 cctaggcttc tcttgaactc ttggactcaa gcaatctgcc cactccagcc tcccaaagtg
11161 ctgggattac agggtgagcc acctcacccc accaccattt tatatttttg acttcttttt
11221 taaaaaaata aaatctcaca tctcacatat ctcaacccgt tattttaccg aactcatagt
11281 caaattgcta agagaaaccc actgccaatt atttttttta aatctgtttc ctgggttctt
11341 tacattcata tttcttaaaa taattttgta ttgcctttat aatatatggg ctttttaaat
11401 tttggtatat gaagatttag cttttctcat ccttgtcata tattacgatc ttggttaaac
11461 taacatttgg aatttatatt aacttgcctc tttaatattc atttttgaga aaatttggtt
11521 cttatatggc aagctttact taattttctt tttttcctta agttattaat tgcttttttt
11581 ttttacaatt cgctcagctt tctgcgtacc tatctctaac tgttctcaac acttccaaga
11641 gcacctcttt caatactatt tttcacttgg ccagacacat catgaatttt gtcaatgctc
11701 ttctctcctg catgagcacc ccattcactg cccacgtgca gcctagaact ctccatatat
11761 ttttgttttt gaaattcgtg ttatggtgga gatgtcaaag acaaggaaga gtcacattct
11821 atgccagtgc tatccctggc tttgaccttc ccacctgggg tttttaaggg tagtacctat
11881 gtgtgtggcc gacgctcagg tgaagatgca aagcagtatc agctctggtt ttgagtccca
11941 gccaagttga tggacactct gccgcagttg cacccatatg ttgagaaaac aaaactacag
12001 gctggctctt ctgctagtgc ttggtcacag tgtataccag ttcacctccc tggagacaaa
12061 cgccattcga aattgggttt tcagggccct ggaagtattg aattaatctc taaacttctc
12121 tagtttctgt ggagggccaa ttttttttat tgggctacta gaaatgtctg taccccaaaa
12181 tacatgggaa tcaaattcag atttttaata actgctaatg aactcttcat atttgatatt
12241 tgatctccac atttgatatt tgatttccat atctctatat ttgataagat tttctcaggt
12301 gttctttatg cctgctgcat ggctattgtc tttagattct ccttatctca tcatggaagt
12361 cctctattct ttgtgtctct ggattcacaa agtattgtgt gtggggtcag ggtatgcttc
12421 tatgtggtta attcgctatt ttggtggagc atatcttcaa ggagcttcct gagataggta
12481 gcatggaaag taaaatgttt gtacttagcc ttctcaaaaa tcatttcctt ttacccttac
12541 acttgatgga tagtttgtgt tagattttta gtttacaatc ccttccattt aaaatttcaa
12601 aggcattaat tattatcctt ttctttttaa gcctctatta ttgctgttga gatatcgttt
12661 gaattcttat cttttcttct ttgtagttaa cgtacattaa ttaattatct ggagaaacct
12721 ttagcatctt ctctacgttt tctgttttct gaattattat gatgtctcac gctgcaagtt
12781 tatttatttc ttgtctttct aatgtggaga tttgttttct ttagtttaaa gaaatgtgtt
12841 gtattttgaa taacgtttct tttcatctct cccttttctg tggaattact gctagttaga
12901 atttgagcct gataggttaa tcacttaatt gttttttaat aattataagt ttttttgttg
12961 ttattgctaa tttctcttca gtgaaaagcc attgttactg acatgctagt tcataaattt
13021 tttttctttt tttttttttt tttttttttt ttttttgaga cacagtcttg ctttgtcatc
13081 caggctagag tgcagtggca cgacctcggc tcactgcacc ctctgcctcc tgggctcaag
13141 cgatgccccc tatcttagcc tccctagcag ctggaaccac aggcatgcgc taccatgccc
13201 agctaatttt tgtatttttt gtagagacgg ggtttatgcc atgttgccca ggttggcctt
13261 gaactcctga gttgaagcaa tctgttctcc tcggtctccc aaagtgctag gactagagac
13321 atgagccact gcgcctggct ctccagttta taatttttga ccttgtttgt tcttgtttgt
13381 ccttttttga gcaaaacatg ggagatcctt atttagtata gtgatcattt agtgatcata
13441 caagttacaa tattttaatc ttatttatca tttgctcatt gcttttattt ttggtttatt
13501 ttactatatg tgttattatt atttatagac aaaaatgttt attatttctt tgaagcctta
13561 tggcttctta tcttgcttag gaaattgccc ctcatattcc actaagcctg tacaaatctt
13621 acttggattt ccttcaaaca tttttattat tccattttta aatttaatct ccttaattaa
13681 cctgaaaatt atttggtata tggtaatgac tagaagtcta attttctttt cttactgaag
13741 aaaattatgg cagaactatt tgataaacca actttttcta tggaatgaaa tatctgttcc
13801 attggaattt ataataatca tttactttaa aaccatatat ggactggtta agttatccat
13861 ttgcccattt atctatttgt ctattttgtg taatttaatg ttgttttgaa tacagaaatt
13921 tttaatatct gataaaacaa gatttttaat tttggcaagc tacatagcac ctgtaatgta
13981 aatggtgtta ttagttgatt gcctatcatc attaagtatt ggatgttttc ctgcccaaac
14041 caattaagat agtcttatga atttaaaatg ttttttcatg aaatagctct gtaaccttca
14101 atatcaaaat aaaaatgttg gtaagtacaa tggtaagagt caggtgatgt tagattagct
14161 atctgtagat tctaactctt tttaataagt tgactataaa actctgcttt gaatggtttt
14221 actgctctag ttctctgttt tcttgactat ataaggtgga aattattatt tcaattattc
14281 catatctata tctcctactg tcttgtgaca aatgaaccag acaatgtgaa ggcatttaga
14341 acaaaataaa cattatatat ttgtgatatt tacacatctt ttgttaattt tctacatcta
14401 tactaagaaa atattcttgg cttatattcg ttgtgttatt tgctaagttt tagtattctt
14461 atcttgattc aaaagcctct ctctcataag taaatcagag caacaactcc cagtgcaaca
14521 tttcagagac ttctaggtaa agaagacatt tcaaaaaata ttgaaaacta ctatttcaga
14581 tattaatctc tgaaagtcta aaatattctg ggctttcatc aagcaattga caatgctttg
14641 atgtgtgcta agacgaagaa atacccaaga tcgcttccag aaatttaatt catttaactt
14701 tttagtggtc aatcgatacc ctccagagat gaatctggct tagatttaag acacagattt
14761 ttaaaaaata tttcaataat agggtatttt gcagtaaatg ccattaattt taaattccca
14821 gtgaataatc caggactaga aataagtgac actggatttt agattcacgt aatttaggaa
14881 aatgtgataa ggtgataagg tccagggaaa tcacacccca aataggagga ggctttcccc
14941 ttgcaccctt tgctctagct tcactgaata acttctcttc tatatacccc caatcttttc
15001 ttccatctgt gatgttcctc atggtgttct tcagtctgaa cttggcctca ttcattgcca
15061 catgtctaga ccttgttcaa ctttcaaagc agtcactact tgtaacctct ttcacaaaac
15121 catgctcccc accatcactt ctacagatgc tgccatgctt ttcaatgctg aaattccaaa
15181 gcatataatt ttccctctgg cttatatatt tttattgtaa ttagtcattg catcatggtt
15241 attaaagccc cttctcagga tgattgttaa aatatacaat aggtgtggta cagtcaccaa
15301 ccaatctgaa tggatcctgg ctgtacacac ctggttcagc aagcatgctt actggctgct
15361 gatgaaatag aaccagccat actagatgga cagtatgctc cctcagatca gtatatgtac
15421 tgaattgatc tctgtaggat ccaaagtttt aatatagtgt tttgcatata atagatacac
15481 tcatatatag cactaatcaa ctttggaaat ataagaaagg tagcctaagt attgggaaaa
15541 ataagacagc aaggtcacat atttgtggag tgaattattg gatgctataa taatagctgt
15601 tattatactc taattgagga tcttccataa tggtttcata ttttctcttt gagagtagag
15661 cctagcaaat ttctagaatg tttgagattt atttgttctg gaaactgaat ttccattctt
15721 actgaaacta aattggattt tataaagata cttaagaaaa taaatgattt attaggggta
15781 tttgttcttc aaaggtatac agccaagaaa attaagcttc atggaaagtt gtgattgtaa
15841 tactttttaa agatgataaa cacctggttt aggagactta atggatcaag gcagctacta
15901 catggatgct cactggcaaa aaataactat taaatacatc catcttaact aatggaaggg
15961 tcagctagct taaaggatgt aattagatgt ttttagtgta aattgggaaa acactcatct
16021 gtacaatttg aaagtctaat tggtttgatt taaatgttaa agaaaagtgg tcgtgtatag
16081 ctctcattgt caacaagtgc acaatatttt atcaatcctg aataatgatc atttctttgg
16141 atgggatcaa aatgactctc acatatactt ctaatttaat aatagctaca acttaaagga
16201 tgttaactgt atgccaaata caacacttat ttttgcttta catatgcact taattaaatt
16261 gtggaaattc aatgattgat tagtggagat agtctgaaaa agtattactg ttttatacta
16321 caacttaggt tgaatcccag aacccttcat agggctcaca ttctgaccca ttgaactaat
16381 ctcatgctgg gattaaaatt cataaacaac ttctgtgaat aaggtaaaac attattagag
16441 aaaatgacta agtggaaaat tattgttttt aaattagaag cagaataaat ggacttgctt
16501 aataagaata acaagaacat ggctatttaa cattaaaaat actcaatgac attctcaaca
16561 gaaattgtaa ctccctaaaa cattactttt tacattctga accccataaa gcaaaaacaa
16621 gaataaaaat tgtatgtgaa caaaccgtct aaaagtgatt acttaaaatc tatgatatac
16681 tctggattaa agtatgctgt cctaaagcaa atctttgtag atgagtattt cttagagtgg
16741 actaaggtat tcataaaaca aagtgcttaa atgaataata taagtaatcg agatgaagtg
16801 gaacatttca aggatctata atttcaagaa aactgtgctt atctacagag tcacagtttt
16861 tctgatgtcc tggtgaagga ttgaatggag gaaaaataca ataaaagaac tatatatttt
16921 gtctaaaaaa aattgaattg actcgtttgt ttttgttccc ccgctaaatt ggctgtttat
16981 gttcactgac aacaaaggca aataaagata attatttgga tcactcaaaa caaacaaaac
17041 actgattaaa catatatctc aagtacaaca caaagttgat tccatatttc tacgtggaca
17101 aaacaaaatc ttgcactttg cattgatgtg tcctcctatc tgcatagagc aaatacattc
17161 ttaatcattt tctcctcact ctgtttatat attctttcta atttaaaatt gcctctgaaa
17221 gtctaatatt attgcagttt tcttctccat attattaact ttttaaaata ttttgcttat
17281 agtgattcat gcccaattca tatagataYg tagattataa atttgattat tgtcaaatgt
17341 taatagcaac tcagtgaaaa acaacttgtc caaaatgttg ctaccaaaag ggcacttgac
17401 tataaataac tcacattata ttacatattc tgtcttgttc ccatcYtcaa cccccgcccc
17461 tctgctcaat aactaatcta agatcaactg ttgatcaggg tcagttcgct aaaggggaaa
17521 catattgact cataagttta aataaaaata aagtcgcctc tgattggctc cttcttggaa
17581 agcaagcaag ttttgtgtgg gactgatatg aaagaagaaa gcagtattag gatgaataat
17641 ttctgttcat tgacagctgt taacatttat actaaaacaa ttttatttat aaactttagg
17701 attaaagaaa ggtaaaatta agtagctaaa actatgcatg aattgcttca ctatatatct
17761 aaattctaga ctaatacgaa aatcaatagc tgctaattgt atagatgatc atatttgtta
17821 ttcatttgct caacaaacat tctctaagca actctgtggg caaggctgtc tgctaagtgc
17881 tgggatacca agaggaataa gcgctatctc tggtttgaga gttgttcagc cttatggagg
17941 agacaaaaat agaaataggt aatttaaatc aaagaacaat gataaaatat gcaaattctg
18001 tcaactgtgt tttaagagca tagtaggaaa aggaggcaaa attggggaga gggtgaatta
18061 agtgcagggc atacgtagct tgatgcatcc atgtaaaata ttgtgctggc cctatactta
18121 tatgctctca gatgcattct tcggtctctt ccttcctttc ttctcagagt agctgccctg
18181 tacagttttc cagacctctc cgtcaactgg cttccagttg gttttgatca ggcactggca
18241 gagattggag aatgggagga agagagaacc aggatattte tccccatcct tgtctgtctc
18301 aggatatatt tctggcattg gctgaatttc tttcatgttt cttgctccca gaaagcaggc
18361 ttgtcctggt ttcggctctc gctgtcctct agcttatggg gacaatagct atttttctgc
18421 tgcttcacta tcccccactt agtttctcag cttctttcac gagtatatca tcaattgcta
18481 gtcatttgtt tcctctattt caaatattca gagccatttc tagtttcctg gttggacaca
18541 aatgcctgac atactgagtc taaattccag gagtttgggc agcaggtttg ggactaatca
18601 acatataaga gagagttcat gagtgtacac agagatacgg taggtaaaaa gattggtaga
18661 ttgagggtgg aaccctgaag tatatagcaa gagataaagg aaacatagct tttgaaggcg
18721 tccaaagatt aatttacaat ttcgaataga acaagaaaaa tgtggcattc acttaagccc
18781 ctgagaaaac ctaggtatca cttagaccca gcatttgtca gatgaggttt ctgaagRtag
18841 agaaattagg tcacatatct aataaagacc agaattgaaa cctaaacctg tttccctatg
18901 tagtgctctt gtgataacac acccattatc atggtaatag tgtgacattt ggtgtcattt
18961 tcacttgttc tgtccttgtt ccatgtgtgc acttcagttt ccttttatat aaagccaata
19021 tatgttatta gttacctcat aggtaattgt aagaattaaa tgagacagtg catgaaaagt
19081 acttagaata aactacttag aatagttaaa tgtatagaga gaggttggaa tgacacatga
19141 aggactatag ggctactaKa ttttatttat tttatttttt gagatggagt ctccctctgt
19201 cgcccaggct ggagtgcagt ggcgagatct gggcttactg caaactctgc ctcctggatt
19261 caagcaattc tcctgcctca gcctcctgag tagctgggat tacaggtgcg tgccaccacg
19321 actgtctaat ttttgtattt ttagtagaga tggggtttcg ccatgttggt ctcgaactcc
19381 tgacctcgtg atctgcccac ctcggcctcc caaagtgctg ggatttcagg cgtgagccac
19441 cgtgcccagc cagggatact agattttatc acagtattat gaaaggtaag cttgtcatcg
19501 taaagcttat agatactcct tttatatgtt tgctgacgtc aaggattttt cacatttggt
19561 aataatttat tatttgttta ataaaacgaa atttgaactt aaatttggtt tgtctttaga
19621 agttagttta gcaattaatt tttctgtaaa atgattttta caccattaat ttcttctcag
19681 cttcgtatat ttaagaattt ctatggactt aaatgaggtt ccatgattga ttttctattt
19741 gcatgatatt ttaaacaaaa tatatgttat atttttaagt tcaagatttc cctcccaccc
19801 tgggaaagtc ttctgagtct ttttcatgtc atccttctca tttttctttc tcttttaatt
19861 tttcagtacc ccaagttact ttaatgttaa acacaaatga gaaaattggg gaattgtaaa
19921 atgaatacag tcattctcat ttaatagata atgatatctt actacctatt gcttttgcca
19981 ttagtttgta acatttaaat tcatgttaaa agaaaaacaa ctgaaacact tatactgtag
20041 aatgcagatt cagccaaaat ccaatattgt aaatttttac ttaccttcag tgtctgctag
20101 tcctactcct acccctggct gttttacagg ctcttgtcca ttctgtccca tcttccctct
20161 gtttagaaat aaaataaaat gatatattca gttatgatct catgaatgca aaagaggcta
20221 aatttgcata aataaaatga cattgatagt aatggcaaaa cctgcaatta cttttgcaca
20281 accgaatatt tttggacttg caataattat ttgaatggca catacataca cagttaattg
20341 ctctatatca taattttaaa atgtgaactt gtttattatt cctattcagg ccaaacaata
20401 tacctcaaca ttcagtagtt tttatttgta gactatttat caaaaaataa gaccatcatg
20461 acatttagaa attttgtttt agaatttttt atttatttct aactcaacaa tgagaagggg
20521 ctttatattt ttatatgttg tactgatgag ttattccagt ttttttggta aaaagagcaa
20581 tattgaatta aataatatat aaaaatgata ttttaataaa atatttctta tttcatgtat
20641 ttttttttca actcctttct gtgttttcca ctgtgttgag caaactggct tttgtagtca
20701 ggctgcttgg tctctgtttc tggctttgct atttcttgct atgggtaatg taaggcaaag
20761 tacctggtca agactgtttc tccttttgtg atataaagat aataatatta gctacatttt
20821 gattatgaaa aaaaacacat gaaaaatgcg tgaaaagggt taacagagtg cctgagaaat
20881 aataagcatt caataaacat gRcatattaa caggtaggca tgStcgtagt agccttagaa
20941 ttcaaccaaa atctgctaat cacttttagt tttcagcttc aaactttttg gaaagtcaac
21001 tagatgaaga attcaggata ctttgaggac tgtaagctta gaatgttaat aatttaacag
21061 ctaaaSgaca gtagaccact tcttatttct tcggctagag aaaaagctac atggcacatg
21121 aagaagtttg gaatttgcct ttatatRtgc ttagataagg cgttctaaaa agatggaata
21181 aaaaattgtt acagaaagat gcttgaacaa aagagcatct tgatactgca ctttgtagac
21241 aacacttcta gcatagtggg atttactaac aattaattat aactttcata ggaagtattt
21301 ggtttgctag acctgctgaa aatgtaacca tatttatttc ttaataatcc aattatatct
21361 tacttgaaaa ctgctctaaa ggtcctctta ttctacttca gagaaggtgc tgaaatgttt
21421 ccgcacataa taaaagaaca catgtaaatt cagaaattat tttatctcaa aagccattac
21481 attgttccat tataataatt ctaggttaaa ggtttaagta caaattttta ttaagtgtgt
21541 atgtgaggga ccaagttcat gcaaattaag caatttccaa catttccatt ttaccatata
21601 tatgttaaac catggtctgc atggtcaaca tctgcataca tatttaagta acacacaaaa
21661 ttttagctta tgtaattgct tcatcaagat tcaagacaag tagttaagaa aaaaaaaaga
21721 actctgctct atctgttagc attagagggg aaaaaaagct taatagcagt aatcttactt
21781 ttatcagtac gctacactgg tagagtgaac caaaacatac cttgttgctg agccaaactc
21841 tattgaaagt gcaggtcttt ttagtattgg taatctagta gatcagaata ctaaaaaata
21901 aatattctta tactatccca gacttttaaa aagtagttac tgtaagtctt agtaattgta
21961 gtacaagtac attttgataa tttttggggt tgttcttgag tcttagactt tatatgttaa
22021 tggtgatacc cagccagtct ttgctttcaa ttgaaactga ttttaacata ggtacttagc
22081 caatatgtgt agtaagtaca ttttgaagat tatacaaaaa actttcatag gattgtgaag
22141 ctaaattaag tgcaaaggaa atgtaactgt gagtcgtgtg aaggatgtgg tttctctgaa
22201 ttcccaatga ctacacttta gctcagaaca ttctggctat acattttata atttatattt
22261 ttaaataatc gctagatatt tattaaacac ttttactagc ccaagctata attttattag
22321 atacaatggg ggatataaaa gaactgccaa atactacttc ttacacatat cctataatgg
22381 ttttcaaaag taaatattcg ttgtgctcat atggcaaagc aagagtctcc tagacagttg
22441 tgagaagctt tgatttacaa gagaaacagg aaaatgggaa aaatcaaaat tagaatgtgg
22501 tatatatata aaatacataa tctacttata ctgcagacat tcaaatattg acaaaatgac
22561 atatttactt tttggaatta taactttacc atcagtgtta aattatatat tttgaaaggt
22621 gcagaaaaat tggaaggata acaaattatg tgtggtttaa aacctttcta aattcacatg
22681 acatttacag cttagaaaga aatttaaaga atttgtagaa attcttttct gtcaaattgg
22741 atcatcagaa gtcaaagacc aatgggatta gatttctttt aggaagaatt tccaataaaa
22801 tataactgat taagtacaaa taactctatt gaatccatag actaaatctc ataaaagaaa
22861 agaaagctaa gatggacagg tgatacaata agaatttgct taatttaaat tgaaaaaaat
22921 gtagttcaaa acaacaaaat gaactcgttt ttcactgtaa aaatctattt tcactaatgc
22981 tttgctttta taaactgaac cattatcaaa atattataat tgttgtggac atcagaagga
23041 aagatttata agaaccttta ttttaaaaca aagagaaata gacaatccac cccctgaaaa
23101 gtcttcactt agcattggag aaaatgaaaa agaccctttc acaacccagc tcagggttgg
23161 caagctctgc aacgtgccag ttagtaaata ttttagatgg gctgtattct aacgacttaa
23221 ttctgccctg cagcacaaaa gcagcatcag gcaacacaga gctaataggc acggttgtgt
23281 tccaatacaa cttagtttat attcactgaa atttcaattt cctataattt tcaagtgtca
23341 caaaatatca cacttctttt gttttttcct acactttcga aaatggaaat gccattttta
23401 gctcacaggt cttagaaaac caggtggtag actgcttttg ccctggcgta aaccctggga
23461 cctgggtggc ccagtggtat tttcaaaatc cagaagacta gttaatgggc aggaaaagga
23521 aaagtcagga agtttggatt ttgttattgg aacagacata atctacatat ttatcttaaa
23581 tgccaccaat atgaccaagg cgattctaac acattaagta tgctaaagtt ttgcatttga
23641 tttgcaaaat gacttttttt ttattttgag gcttaacatt atgagtgatt cttattccaa
23701 gagtacctac tcagggacct atgcactact cggtctttgt tctagaaagt atggaaacac
23761 ttcgaaacct tcaatgttaa ttgtagaagg atttatagtt gaaaagtctg tatgattatt
23821 cactatgtcc tctatttcaa atatgatata tggattcttt gaatatgttt aaatatctcc
23881 tgattcaagg taaattaata tatgtttgtc tcaaatacca gtaatgtttg tatttggtca
23941 ttatgtgatt aaaacattac tgtattcctg ctgaacttta ttctggcatg gctaagtgat
24001 tagcagtttt aacatcaaat acagattgta ttgattaagt agttctggca gtgactaaca
24061 tttatcctta gaattaactg aattatccaa tctttcttga actatctatt tttacatagg
24121 cattaacagt tcaagtgtct cagggacaat gactcagaat tgggtaatta tccagttatt
24181 tcctgttaac tgttgagaat gccttactca tgatgctgag taagctttgt agtaacaaaa
24241 agagacccac ttacatcctc ggaataggaa atagattagt ctcccctgca gtgctgctgc
24301 ttccttcact gtccacgcta tacccactgc caaagctgct gcccgaggag ccggtggaca
24361 cagagctttc tgcaggccgg tgattgggag gctttgctgc atggtgtggg aagattcaac
24421 accacagtca ataaatgaag ctgacattga tctacaaatg catcattata catcttctta
24481 atttacatgt gacaagaaac agctactgaa gaactctaca tttttcaacc cgccttttcg
24541 tttcctttac tgataatgaa tggtggcaac aataaattat tttactgttt ttattggaca
24601 tcaaggaaaa gcaatcacct ttagggaaaa acacatttaa tttttagacc aagttaaata
24661 gtatgtaact atgctactat tattattttt gtggtttctt tgtacagtat tgcaaaaatg
24721 atatggtaaa taaaaagaat tttggctatt tcatggagaa aagaatttag aaagacttgg
24781 gtagatagaa atggcaagat aaagaaaatt gcttattttt ttcctattac tagactataa
24841 tctgtttttc tccttagaaa caaaaatgca aaatagaatt ttaagaagtg attgaaaatt
24901 ctgtttgttt gtatgtacct ctgcctacta tctccagcaa ggttttaaaa tttaaagata
24961 tttgtttctt ttcaggcatt tcctagttta tcattgagac ttgtctcaag aatttcctaa
25021 gtttgatatt tgaatataag aatccatatt cccatacaga cattacaaat ttgtgcaata
25081 aattatgcag taggggtata gtactaatat tgttgtcaga tttgagaaga aattttgatg
25141 caaaaagaag gaagataagg caagtgtttc cctgattttg ctggggagaa gtttctctag
25201 taagtttttg aaatcgttga tatttgtctt ccgccagaga gagtgaactt ttcggtcaca
25261 ccgatctggt tttgactccc aacccactct ttagcaactg tacactgctt ttctcatttg
25321 aaaacaatgg gagtcagtaa tgcctacctc ataaaattgt gattatgagg agtgagatat
25381 gtaggagccc agtaacttac tcttcttcct cttgtgatat tatttgccac atcaccactc
25441 ttctcatggg ctttactgtc aacagctgtt tcttactgtc tttgagctta aatagtcttt
25501 gacaatgaat ttaactctat tctcttctca aggtatcccc actcttctca agggctttac
25561 tgtcaacagc tgtttcttac tgtctttgag cttaaatagt ctttgacaat gaatttaact
25621 ctattctctt ctcaaggtat ccccactctt ctcaagggct ttactgtcaa cagctgtttc
25681 ttactgtctt tgagcttaaa tagtctttga caatgaattt aactctattc tcttctcaag
25741 gtatccccac tcttctcaag ggctttactg tcaacagctg tttcttactg tctttgagct
25801 taaatagtct ttgacaatga atttaactct attctcttct aaatctagat gtgttcaaac
25861 ctacagttct acttagagtc ttttttcttc ataaatgcgt ccctatccca ttaggagttt
25921 attagccagt tggatagagt tatactaatg ggtgaacagt tgataatcat ttcacgatcc
25981 taagatatct acatatttct taaggatatg tataaaaaca caattattct taatctggtg
26041 gaattttaac caatataata accacatgaa gtgaaacaca taaacattgt gtgggaaacc
26101 atttgaggac aggaaatcca ccctcagggt agctaggatc aagtcttgca aaggatttaa
26161 cttttccccc atttcttcac tttttcaatt tcgtcggtag caggttctct aaagccacaa
26221 ggaattttta tatatattcc agtggtagta ggatcccttc ccgagaatag ggaacaagaa
26281 agaaattgtt aatagttagt caattgtata tcagatgtgt ataagttaga aacggctatt
26341 taggaaaatg tgttcctaac ttatagacat ctgatataca attgactaat tgaactgaat
26401 gctgttaaac aaccagtcat caaggaattg ctagtaaccc acaggactgg atttgtggaa
26461 acagaatagt tatgtttctg aatattttct ttattttatg tagaagaaac ccagatggtg
26521 tagttagtgt taaaaaaaac ttcttaaaag aataatttta aaaatgtaaa ggtaatgtga
26581 gtaggatgta aaatgatgga catgtataaa gtagattaaa atgcataacc tacataatga
26641 gtcagattag tcaattgatt ataaacaaaa gaaagctgtc atactttttg atgggattct
26701 ataatccaat tcataatttt tagtatgaca ttgaatggaa gacattaatt tcatcaattg
26761 gaaaatcaca atttactatt ttcaaagata aaccttaatt attagacact aatattcaat
26821 caatttatat ttattaaatt aaaataattt taattcaaga gcaaactcac aatgaacaaa
26881 aatagctaca ttataaaaat gatttattat ctatgtttca aaatcgtcca tcctttgttt
26941 tgtcaacttt ggttttacct gatgcgattt ttagttctat tcctcttctg gaaaagttga
27001 gaaatgtgta cagaatataa aatagcataa taagaagaaa gaaacaaagc tagaaataaa
27061 tttaagaaaa gacaggtttt ttttccatct tgccaatctc tttgaataga attctcattt
27121 tgaaagcctg tgcaagtgtt gtcaatattt taaatgcaaa caaataacat tttataagaa
27181 atattaaaaa agaaaaccaa atccagggga catttaccta tgatggaatc agtctaacat
27241 ctctgcaaaa catgattaca tctaaggttc tgtctatgga aattttaggc agttagaaat
27301 taggtgaata attcaaatga atctagttat ttggagttat cacaacaaaa catccggtgc
27361 tggattaaat tctgtattct taacttggta tctaagtgta gtgcagagat atatagcctc
27421 acatttggtt agtttctgaa aaatgaatta aattaaaaca cacaacagat cttttcttct
27481 tgctgggctg tatctgcata tcataaaatg tgataaaaca aaaaatggag aggttttgat
27541 aagctggttc taagaatccg tattttaata tatcttttcc agatacttga aacatgtatt
27601 tactcatttc tttctcttga aacagacttc aagaaataaa acatcaattc tattaaattg
27661 agctaaatct gcataaaggc aaactttttt ttaacaaata aagtgtattt aggactttat
27721 tatctgaggc tggatcttag gtaatttcaa gacatctaat aatttccacc acattcttta
27781 ttttgcctct caaaagagtt ttttattggt ctggtctttc caaatatatc tcttgtaatt
27841 ctccttcaaa cactttacat ggaagccctc tcagtccatt cactctggct ccctttggtt
27901 tggctttttt ctttccaact ttactaagct ctcttttatc ccatcacttt cttgtatcta
27961 aattaaagtt atctgtaaag gcctagctca gaaatcacct gcttcatgca tttttcctca
28021 ttctcccatt cagaagtgac ctctcctatg tctggactct tgtagcacat actctgtcgt
28081 tattggaagc aaagcctatg ttttctcctt ggtaacttcc ttaaaagctt gtcccggaac
28141 catgtttgaa caatatttaa tgaataagta ataataataa taatacatta atacttcttt
28201 cctttaacca atcaaaacat ctgaatgatt tagtagataa tttcactttt taaatcaagc
28261 tttgtgtttt atacaaatca taaatttctc aacaagaagt ccacttgata tggaagcttt
28321 ttttccatgt tctttgtcaa agaaacttta gggagtcatt ttttttagct tttaaaatca
28381 gagataactt tactctgtca tactgtatag aaaaaggtga tcattcaact atatttttta
28441 accccaatct cccaaaacac tggtttgatt gaaggaaata tttaatgaga atacactaac
28501 catcagagat tataagctta tgaatttcaa aaagttcata atcacaaata ttacatatat
28561 atttaaaatg aaagtgacaa aagaaaataa tatgtagagt aacattctgt gggagccagc
28621 actattacag actctagaac ttgtcctgat cccatgtttg tatgtaggta gttggagagc
28681 tctgggttat atttaagtgt aatatatctc tattttttat gttattgagg gaaataatat
28741 tttaaacaca ctaagtataa tcttccataa ttttataatt tcaaaatcaa aaatttagaa
28801 atattcaact tctgctttat tcttccaact cttttaatta gagtttcaga aaccaaggac
28861 ctactatgtg tgaatgtatt acacacctgt gtattacata tgaaaaaagt ttatataaac
28921 attgagaggc ttttcttagt aataagatac atctttgggg ccatttttta tgaattacat
28981 ttttgtgtct actttctttt tgaaatcYta agtgtattac taagtaccaa gtaaaggaaa
29041 gagtggatgc tataaatata tgatagaatc agctcactca tagaaagggt cctgtgccct
29101 aaaagaataa atcttagaac gttgaatcat ttttgtaact caattaattg agggggcatt
29161 tcaggtaaac aaatgttacc ttctgtgatg caattcaatc tgttttaaat tattctttga
29221 ccatttcact ttctttggct gttagatggt tcaacatcat tgtgttttat tactccattg
29281 tggctaacct taattaaatc ggtagtgtct ctttgactgc acatctgtct tcaattagtt
29341 tgctctgttg gcttttcttc cctctaccac acagtactta aatatgcaaa gctatcactg
29401 tacttaccac atgatggcag cactttgctc tgagagcacg gattaaattg tagacttcac
29461 ttttactact tttatatcac atccagttat ctgaaattta aaaggcaagg tctctgccta
29521 tcctactaaa ttccaaaaaa ttagtgtttg gaatgtaaat aggttgctgt ctatgatgtt
29581 ccattattgg ttttatatct ttggtccagc acagagctat ttccaaatat tctgaggagt
29641 aatttattat gtaggtagct tgtactttcc caaattactt ggttaataca gtagtaaata
29701 tcttcctaga tacagtctct aaaattttaa gattaaccga aataaaaagc aatcaataat
29761 tttgtttatt ccaatactta atgatggaac ggaaataact acctagcagt tttagaaatc
29821 aagtatttgg gaatttttac cccctgtagc tagctttaat ttagctagta tttacttcag
29881 gtacctttct cctctctttc tttgtttctt tctctgtcca tccctctttc ctttccttct
29941 tccctcctcc tgtctctgtc atctacctgt tgttattgct gttactgttt ttgttttttg
30001 atatttttac taaagggatt ttgcagtttt atctcatgtt ttaattttct tttgaacgtg
30061 gacctgaaaa tttcaggttt taagtgtcat tgtgccagca ttatttggaa tgttttccct
30121 tgaattatgt acaatcacac ttcatgtatg ttttctatta cagttcaggg gttctagttt
30181 aagaagaggt actgcatctt aaaagtaatt tagaagttta atttttttcc aaatctactt
30241 cagtataatt attatctatt tgggaaaatc taaagcaaac tggacactag aaaaatgggc
30301 tagcttcaat agagctattt gtagttttca cacaccacca aatcacaagt tttcacaaat
30361 acaggtgttg aaactctgat atctctatca gtcatttgta agtcgttagg catggaagtt
30421 gaaggaagga tgtcattgac aatttctttt ttaaatgaca aattattaga tgactattag
30481 tcattacaga tatattttat atatatatgt aaacaatata tctattataa aggtatgaca
30541 agtcatgaga aatggaatgt tgcaggcttt tttcttataa aaataaaaat atttccctta
30601 agatatgtca tattcacata gtagctcctt ttagagaaga agatgaagac gggttgcctc
30661 catttgctgt gttccagaaa gatggtaaat ctcgtatatt cacagttttc tctctccatg
30721 cacattggcc ttatgactga attcttaatg acatcttaat gaacaattta gtttgtttat
30781 aatgattcat tatctggctt tatagataat aagatcaatg atcacttcag gaaacagaag
30841 taatcgtata aaacaatgta acaaatgaaa atgaagttag cttaactaat agcacggtat
30901 agaggaattt tttcttacat gaaaaaatac atgttggctc cgtatactat aatccttgct
30961 tttaaaagga aatcataatg ttgcctttta agtaggtctt cctttttttg aggggttttt
31021 agttcagaag tgattttgga agaaaccact taaaatatag tttaagtgag aattaaaatt
31081 gtatagtaaa taatgaaaga aagtttgact aagacattat catagatgaa aattaagaaa
31141 gtaaattcat tttgtcttta ataaattcag gccgtaattc cagctatgtt cgaataaata
31201 gaatgaaaaa agaatgtatc cagtgctgag ttccggtttg gtgctataaa atgcaaatac
31261 aataatgatc tttatcttta aaagattaat agcatggggg atcatatgtg aaagaaaaaa
31321 cattcaattt tgagctacat caaattttca tgggcgattt ttaatttttc aatcttcctt
31381 ttattctctt ttgaagcaga agcattttct ttcttgctgt ttgcttgcac tacacttgca
31441 ttaggctgtc agataggtat ttccaactga caattggaga aaaaaaaaac tcaagcagga
31501 ataaagacta ctgtaaaaca tgcaggtttg tttgagtaaa aagtcattct aaaaatagtc
31561 attttgaaaa aagttcttac ataatcctga aactgtgaga acttacatca cgactgctta
31621 gataacaaga atgctgtcct taaatggaat ccgaacattt tgaaaattca ttaaattttg
31681 cccaaatgaa aaaggttgag cacatttcca gtttgttttc atattattcc aatttggtca
31741 atggccacga agtaaagagg aagtttggac agttatttga taaatgcacg tctggtctca
31801 tgagacctaa cctctctagc taatgtcatt aatctttctc caaacagatt atattaatga
31861 tctattaatc tataacaatc atttcatcaa tctttctcca aatagatcct taaaaaatac
31921 tttctgtcta tatatagatg gttatattgc agtggattgt acaggttatg atagaaccag
31981 aggcagaaca aataaattat aattaattat attttccaga tatttttaaa catgatgatg
32041 tttggttgca cctaaatgta aatcagtgac caattgcatt tttctttttc ctctcagttg
32101 aagatagaca aaactcactt ttctgactct tcataatttt ttccagatac ctttaaattg
32161 attattcaat aaatattact agcatgagag attcatgaag acagtaatat ttgtctattt
32221 tgtttgctgt agtatcacca acaccttgaa gaggttctgt gacattattt gcactaaaaa
32281 taatatcagc aaatgtatgt aaaaatgatg acctaataaa agtaattcag atcatatttt
32341 tcataaatga taaacacgtt tgcaaatatc cttttggcat taaatatttt gaaactcatc
32401 aaattatata cttgaaattg aggatcaagt atttcgtaag aagctttcca tttttcctca
32461 aatttgaatg aaagtgataa tcttcagttt ttctattgtt atgccaatac aattaatttc
32521 cactatatgg gatcagtaat gtagataatg gaagatgaaa ttaattgata atttataaac
32581 aactgttttt ctataaatgt tactttcaag ataagaacaa aaaattttat tctaccttta
32641 taacacttct gtcactctac ttcagcttgg aagcagcttg attaaagctg ataggcaact
32701 tatgaaattt caaaaggaaa aagtaacaat tacggatgtg taaatataat ttaatctata
32761 tcattcccaa taaaataaaa aattgctata taaattgaaa aaatgtcatt tgtcaatctt
32821 aataattata aattaacatc aaatgagaaa ggaaagaagg ggttctgaaa tgcaatagaa
32881 gagatatata agatacagaa aatttggaga caaacatgat aaacatgttt tggaagaagt
32941 ccttggttat tcagtctttg actattgtaa aaattatgat tgtgcataag tctaagttgg
33001 tgacttttat atatttttaa gcttaaatat atttaaacac ttcaacataa tttaatttat
33061 aataatttat aaattataat ttaatatact taaatgttta agctggacaa caagcttaaa
33121 tattttagtc ttatcttaga acttatttaa taatccaaag aactttatgt tatgtaggtt
33181 atatctactg atatttatca tattcaaaat aaataaaaca ttaaaacaaa aaatcaacaa
33241 gcacatattc cattagtcat caaagcaatg ataacatgac accttatgta gctgctggaa
33301 aactccactg tacactcgag aaaaaaatga gagcaaaaaa gcaaataaca tgttaatctt
33361 ctYaagaata ttttgacctt gcagatccct gaaagggttt ctgggacatc ccccgcccct
33421 accaggaatc agtgagaatt actggtcaag acccacagtc atggaaatga agtactgtga
33481 aaaatgagaa gaaactgatt agcatcagtt tctttgacag tcaccttaac aattacatat
33541 gtcaagatca ttttatcatg ctatttattt ttaattttgt gttttgtact gaaaaaaata
33601 tcaagttttc agctttcttg aaRagattca ttattgatat tagcattcat tttaattgtc
33661 tctaagctNc tNgtttcact cagaacttca caactctaga aatatatggc atgaattaaa
33721 aatatatttt atcataaaat cttgtctatt tttggttaaa aacgaacaaa acaagaaaat
33781 aactatgtta ttgtgcacag aaacccggag taaataatga taattggcag gcataaaata
33841 atgcagattc ttccataaag aggttttgtg ttcataaagt atcttttgta cattaataat
33901 agttggatgg aagcaaaatg gtgattcaat agttattgac tttattaaat gtcattggca
33961 atgaggatgc tttaaaacaa aaactacaYa atagacctat atagaaagac atttgaatta
34021 ggtagttgta aaaatatgtt ttctatattt ctctatattc caagttcttt ttataaaaag
34081 aatcagataa aaatacagtg tgatctatag aacttgaaat acatggtttt caatttgaaa
34141 tgttttaatg aggaaaagtg aattttgcta tgttcttttt aagaacaata tggtagaaat
34201 tatatttctc tacctttctt atacatttgg aaatagaaac ctgtgatcct gacttttacc
34261 aaacatttct tctgaaaaat ttttctgcct tgtttgagtt gtggtattag gttggtgcaa
34321 aagtgattgc cggttttgcc attactttca atggtaaaaa ccaccattac tttttgcacc
34381 aacctaatat tattttgatt aatctgttca aattataatt aaattaacga attatacttt
34441 tcagtatcta aaacacatta aaatataaaa tgatggttag atctacgtca ttcctattca
34501 cacatctacc aaactcaaca ccccgatcaa aattttatat ttcggatata atttggtttc
34561 atttgaaaat tcatgtgttt ttggcttttt agtgaYtcat tatatattta catgtacagc
34621 acagtaataa aaatggaaaa gaatattttc atggtcttgt tcagtataca tgaaaattcc
34681 cttcatctta ccccataccc acgtttcttc ccccagatca tgttgcacaa tgRagaatgg
34741 gtgaaatatt atggtttaca tgatgtatgt aatacatgtg gatgaaaagt ggaaaaataa
34801 ctaagcattt catggatagt tacatatctg gatttgggga ctattattaa atcaacaatt
34861 agtgtctttg gcattcctct accactcctt gggcagcata tccctggttc catgatcctc
34921 ctatccaagt gagaaagttg cctgccccat gctcttattg taccctgact gccccccact
34981 gtgtctccat tggcattctc attgccctcc cccatcagca tttacttgcc tgtcttactt
35041 ccacaggtcc tgctccctgg tggtaatttg atgaactaac tttttgaaaa taattgcatt
35101 acaaaaacta ggctttatgg gtattatttt taaagacatg tcataaataa tatttaagaa
35161 accttggtat gttaaaattt aggcctttct cttcttctta gatcatatat taatagtctc
35221 atcctcatta tttaggccca tagctagacc atatgactaa ggcataacaa ttttgaagcc
35281 aagtttggtg tttagatggg ccagttggtc ttacttttca cgtcagatga aatgaacata
35341 taaatcccca ttgtggacca gaccaaagta tgcagatggc tcggtgcaga tccatggcta
35401 ctactggaaa agaacagaag tacccattga tggtaggtca gtgaattcat cttcaggaat
35461 gaagatccat aaacaagaga tagtgtgata tggtcagagt tctacattta ctgtctgatt
35521 ctgtatgtat agcagaggta tttccagcaa taaatttaaa tgactataga aatatttgaa
35581 aatgcatagt caatcattcc aagaaaatgt agaatctctc aaaaccaaaa cgttagaaaa
35641 gcattttgat tttcacagac aacaaaataa atccttatca ccagagaaat aggtatagaa
35701 ctctgaaagc tgaaattgtc caaattgatt ctctcagatt ttgttggatg tttgctatgc
35761 gcatgtcatt acagtttgaa ttttcttttt attttaaact gctcaaggtt taaaaaattt
35821 ttttgcacaa acacatggaa atgaggaatg taaaatttgt ttttattaat cttgtacata
35881 caatgttaaa gaagacttca cctccaaatg aaattgattt ctcttatgct ttttccttta
35941 tttttcttat gggcctgacc tttacagaaa cagggaaggc taaattcctt ctgaccagaa
36001 gtgatcatct gcttctggtc aaaagaaaat gggatgctga ttagctacta tcatctgtac
36061 ccagcaattc cctccactcc cagtcccacc cactcccaaa cccatccacc cactaccact
36121 tgcccaaggc agcagctccc acagagtgat ggcttagtaa gagttcacca aggcaacaca
36181 tggatatgaa actcttcttt gacaggtgcc gcaaatgagc tttattgaaa gcggagtttc
36241 cagtagtggt ctgtggaagt agcatcaggc ttttctccta caattcagcc acatcaggga
36301 actcgaaatc atatttcctt gcatgaccta tttaataatt tattgtctca cctaatctct
36361 ccaacctgtc ccagtggctc ttgttttatt gaccagggta gagggatatt tctcctcatc
36421 ctgtattgcc tatttctaaa tttaaaactc atacctaaaa tcttagtatc aaacaaaaat
36481 agctcaggtt tttcaMactt aaatttagta tattggattt caactaaata aatcttcaag
36541 gttttaggaa tgcttcaact tgttttggtc ttgatatagt tttcaaacaa accaacaaat
36601 aaaaaatctt ttgaaatggc aaggtttgtg ttcaaccaaa ccaactagca tggggaaaac
36661 aacaacaaNa accgaaaaca tttccagagg tttttaacta cggagagttg tttaggcctc
36721 aggatgtttt tgcacaatct gtctaatctt tcccgtcagg tgttttagca tacaactaaa
36781 ccccagaggg aaagaaaaaa ttccttttga ctcactccat aattcttgtt tgacccatat
36841 tttatgctag ttcaagcaga aatctgctga gaagcttaca aaaaatcttt gaaaagctct
36901 ttagggacaa ttttgtcact cttgatagaa atgcctacag atggacccgc agccttttct
36961 aatggagcta caaacattgc ctaatgcctc actgggcttg cacagtggga aggcttcctt
37021 ttgttgggtt aaatcaacaa cctttagaaa ggaggaccat gtaggcagag agtataaatg
37081 gaattccgcc atcatttcca gctacctcta atcgtttgta agaacttaag agataagtca
37141 taaataagta catgactgtt cttattaaaa ttaggagagt ttgattttaa aggagacaat
37201 gtattcaaaa attataactc aaaaagtcac aagacaatgt tatatttgtc ggttctgaaa
37261 atttctagct gtgtgttctt atatcagcca gcctacccct ctgactctga ttgctcacgc
37321 ataaaacagg gataagaata ttgaaataac Yacctcatcc acttaatgtg ataaaatgag
37381 aaatggatga caaaacactc tgtacaacat gaagaactat tcaaatgcag agtattattt
37441 tcagaatgcg gatgggatta tacgaactcc attgtgaggt ttgaaatggg acacttttat
37501 ctcaacactt atgattatta ctaatacttc tgcagttagt gaacaggaac ttgcaggttc
37561 tttttatatg tttgtatctc tgcctagttt ttctctctgc actttaaaca aattatattg
37621 cattttatat aaatttaaca ctatagtatg tttgcYtgaa gtgcctggaa atatacatgg
37681 atcaattata ttgttacact tataatagca gaaaaattat actttagaaa acaaggcttt
37741 ttaatttatc gtctattaga acaaaattaa acatgaaagc atgctgtgtt atctagtttt
37801 cctttcaatt atgattttaa tgaagagtga cttctaagtc aatcacaaga ctaaatgttt
37861 gagaatatct attagaacac tattcaaaaa aagggattaa aaacacttta atataaattt
37921 taaggactat gtctaggaag aaaatcatat aaaatgtcat atagaaacac ttaagtcaca
37981 ataattaaaa ataaggtgtg aaataaggga agtgtttgat tactgtgaaa tttataattg
38041 aaagaatatt taaaNaacgt gaataacatg aagaaatcaa ctgaacttat ttgatggaag
38101 aaaaggtgag aggtggaatt ttaaaaatga aagttttagt aaggctaaca agaaaaaaga
38161 aattgtgctt tgatgataat ctataaactg ggctgagtaa cacatattca gaattatcct
38221 aatgtttaag ctgattgttt ccttaattac ctaatttagg aaacacctca gtggtttacc
38281 tctgtaatgc gacatatatc ttacattgcc accacatata taattaatag ggagaaggac
38341 atatgaaatg tttttaattt tatgagaata aaaagaacgc aataggaaag tataaggctt
38401 gattttaatt ttgtgccaaa tatagactca taaaatcaaa tattttaggg ctgagaggta
38461 cttaaggggg caaatagtac tatcctattt taaaaaaaca ttattttaat atgtgctttt
38521 gaattaaatt tgaagataat tgtataatca ccctagcttc attccttgtc actggcagtg
38581 gcactctttc ttgggggaaa attctagcaa tgttggggtc aggttacaga tggatgtaaa
38641 tttgctttcc tttctgaaca gagctatgag ttgaaggttg gccacttctg caaagcaaga
38701 gctcatggaa tttaccttcc tctatccagg aacctgagaa gattgcaaag tagatcagac
38761 gtgggagaga gaaatagcag aagtgttgcc tagggcagcc caatcccatt atttatttac
38821 attttaatgc aatctctgat gctttcattt ggtgacaatt ttccatctat cttatagtgt
38881 ttccaagatg gaactttgtc ctgctctcaa atgtccaatc attacagctg tcactagcaa
38941 tgaggcagta attaaaatct attgcaacga aatcaattga gaaaacaaaa ctgacacatt
39001 cattttaagc tgcatcatat aacaatggct cagaacccag tagtttatga atgaaataaa
39061 gatactttat ttattacaca ggcacttgga gattcacatg cccaacacat ctgatacact
39121 taacaactat ggaaacacga gtggaaaatg tctgtttgta ggatcaagag agaactttca
39181 ccatgtaaag gtaaatgagt gcattaacaa tttttccttt actttcctct aagaattttc
39241 aaaatccact aaatttttaa aagttacact tgaaataata ggcaaMaaac actgatccac
39301 attccaactg gtaggctaac ttgaactgtg agcaatttaa acttttatca caatgaaaca
39361 tatttatagt catgcttgaa cagattaggt tagtagcatg cattccattc tgcaatatga
39421 atattgttaa tctatttccc aacaaaagtc aaaagatgcc cagtgcatag aaaaatacaa
39481 atcactgtag tcaatatatt acgggactga tcttgggact tacatggtga tgatgaagtc
39541 ctgaaatgcc atgcccacaa aagcacatta aaaagtggat aaacatattt tatcagacaa
39601 tctctaaaaa ttaaRgatga gagctttaaa tttggggatg ttcttgctgt gtgctttgaa
39661 cagggccttt ctgctcacct ccttctggct tgactggtcc atcagacatc accttcctga
39721 gggctagctg gctttggtct tggttgccat tggctggtgg aggcagatta tcagactgag
39781 ttctttgaat ggggaggact cctgctatgc tgtgtctgtg ctgcttcctg gcatgattag
39841 actgaccgct tttatgtgct gctgtggcag tgtgggtgaa atggaaaccc agagtatgta
39901 tcctcagatg gaaccagctt aaatgttatt catgcaaaca gaagtgctct tttgctctat
39961 ttaaataggt tgtgttttca aatgccaaaa tgacaccaca tgcacagcac taaaggggtt
40021 taaaactggc tgtttctttg aaaatgatga ctagggagat ggagagaaca atgatctatc
40081 tccattgcct ggctaatgcc ttttagaagt aacagggtac ctacatttgt gaaatatttg
40141 cacatattaa gtttttatat aattatatca atcgactaaa ttttcacaaa tgaaatgaaa
40201 atacagcagt taagataggt caattgttat actttgattg acttatagct accagacata
40261 gtatatcttg atttccaatg gttagaaaaa atatctgtaa aatctgtcat cacatacaaa
40321 gtgtgatcca acagaatgga cccaattgtg ctcctcagtg aggttgcatt gccttatcac
40381 atatgcttat acatatatta atttaatgta gttttttgag aatgtaagaa ataagatttt
40441 cttcacagat ttttcagaag actacaattt tttgcacatg gaaagctacc atatttcaga
40501 agcaaaattt gttagtgttt taaagcactg tcttgaaatg gcttttcctc caaggttcta
40561 gaagttgact gttggttgca ttatcttctg cctagacttt ttgagtgttt tcagatacaa
40621 gaatctaatt gcaaatctgc tctaaatact tatatgtgtg cacttttttt tttttggtat
40681 aagtcctgga aaactggcag ccacttgtgc ttataatttc tgtattctaa aagatattta
40741 agcgcaaaca aaaaggacac acaacattgc tttgcttcca aacatcacag acactgtatc
40801 aaatgctaKg agccaggttg gatggatggt ggaaacaaag gagaaacagc cagttttatt
40861 tcagtctatg taaataaaaa aaatctaaat aagaaagagc atattaatgt atttatatcg
40921 ttcttacaca gacaaaggga cagagaacag ggtgagcaga ggatgttgaa aactgaaagc
40981 aaacaggaaa ggacagcagg aaagaaaggc aacagatgaa cattaagctg ccatgctgag
41041 gaatttattt gcgtctttta cttggttgaa tgcggagttg ttgcacggca gcttcggcag
41101 cagctatggc agcccctgca tcttccaggt gggtctgagt gacgctggtt ttgctttgac
41161 tgcgagatgg tccatgagaa cggagatggc cttctgatga tgattttgag ctaccaggac
41221 tactatggga tttctcaatg gtgggaacct gcatgtctgg tcacaaaagg gtaaaacatg
41281 agttaaagtt gttccagcat tcctcctatc aagcttggtt tacacataat ttgaaactgc
41341 ctaaaattta tgttaattct gagtcttata tgattcattt atgcaactgg tcatcataca
41401 gaatgatgat taaacatctg ggaaacaatt tgggggagga aaggcaaaag gatgatagca
41461 atgagaagag agaactttga aaaaagaaat acattctgac tagcttctag taataaatat
41521 gttaactttt agtttcacca agcacctctg ctaattccag cagaggtcag gtaggagaca
41581 atacacagga ggagttttaa gcaaaaacag gatgaaggat gtgaatcact aggacatatt
41641 aagtgtggag attgtagaat catgcctcaa accattgtag agaatgtatg gatcacgtat
41701 ttcctaaggc agtcatagaa agagatcttt atactaatga tcatgcagta tgttaagcaa
41761 gataagagtt gagatggcta agtggaaccc ataaatgatc tataaaactc attcataaat
41821 aatctacaaa actcgtagtc agcagtttat gatatcaact cagtggccta ctggacatgg
41881 actcactttc tcatctccta gaacacttgc atttatgatt cagagaatct catgtacaaa
41941 gaaccacttt acaatttgct ggactttcct agaaaaggtg acaaggaagt aatactcaag
42001 tccaatataa aaattatatt taatacttac aaatagttca gtatatctag gtaaggtacc
42061 acWtgtttta tcccacagag gcagtagctc agtttatgat gaggattaat gttgtgttgt
42121 aggacagttg gttatgaacc tctcaaagga aaagctcatt tgaatgagag tgctgtacat
42181 atttgcatat tgccaaaccc aatgtatggc actgttattt aaaaaataat aatagttatt
42241 aaaaaattag cttgagtcca acatttagga aagacttaag taaatttcag cataccaatt
42301 gttttgatga caggggaaaa tattctttgt atgataaata aaaagtagca tgcaaaatta
42361 tatttattgg gtaagacaat atttatggac aaccagagat tcaaacaatt agaaggatta
42421 taacttaatg ataatgatga ttatgtctag tcaatgaact cgtagggatt tttgtattat
42481 ctttatgaaa tacccaaatg cattttctga aatcatgtta tcatggattt tgaggtggaa
42541 tagaccaaat agctcatttt acatgttgaa attggacagt tagagaagtg aagattacaa
42601 agtactacac ctaagtatgg gtgatgatct gagaataaag cccatttctc ctgattccac
42661 tctttgcatg acattatatt aagtattttc cagtcgtgtc taatctatta atataggtta
42721 aatgtacaaa cattcacact aagaagatac agactgaaca aatagacaca aaactttttc
42781 tacttaaaaa aatatttcct accctttgat gggtcaggga agataccatg gcttctgctt
42841 ttgataacag atggctttgg ggactgctgg ctgctctgac tggaatgaga cttgccatga
42901 tcaatgcttt cagtctgttc tttgagagga taccaccttg gagtgttatc gaggtgagMt
42961 gtgctagata aatcaatcaa tacctgaaaa aaagtgtaac aaataaatga aatttaggga
43021 ctaaagtata attgattcat tactttttct atgttctaaa atttattcaa ggatataaac
43081 caaggaatac agtataactt ttgaggatga tgattctttc ttcctcagtt ttcttcacca
43141 atgatactgg aaacaatgtc ttttacatac tagatgctta ataaatgttt gcttgaactg
43201 aactgtataa aatttttgac tattaactaa attatttgga tatgatgtta aaagataggg
43261 tcacaagtca atctgttcat aaaacaaaac ttctttttgt tgtaagaact tattttaatc
43321 ttacacggtg aaatcccgtc tctgctaaaa atacaaaaaa aaaaaattag ctgggcgtgg
43381 tggcgggcac ctgtagtccc agctgtgtgg gaggctgagg caggagaatg gcatgaaccc
43441 aggaggcaga gcttgcagtg agctgagatc acaccactgc actccagcct gggcgacaga
43501 gcaagattct gtctcaaaaa acaaacaaat aaacaaacaa acaaaaactc ataacttatt
43561 ttaatcttaa actggactag caaccttgaa aaatgtttga ttttagtcac aaaagggaca
43621 aaatggaaaa gaatgagtaa gttgcaatta caaaSttatt tattctattt taaaacatac
43681 tttagttcac atttgaaata gggatatgac taccacattt tgtcatggtt taattggcaa
43741 cttttttttt cttagtacat tggtgcattt tacagttgct gacatcttag atatgatgag
43801 ctaaaaagaa atgaaaacca gaccaatgga tatatgcttt aggctcatgt aaacataaga
43861 ccataaatta gaaggacttc agtaagtcac ttttttgaaa tgaaacataa agtcaggcat
43921 aaYactaatc tagagtactc ctgcctagga tcaagattag tccaagtggc tagagctgga
43981 tggaactgga aggtaagggt caaatgctcc agttttggtg aaaagagatg tgcaaagtct
44041 taagaaccaa acaagtcctc attatcacct tgattacaca aaaggatgtc gtattttgta
44101 ggttttggat tttttggaga ttatttttaa cattaattca taacttctgc cctaagcaga
44161 acactaaaca atgtgtatgt gtgtatatat attatatata ttatacataa tatgtatagt
44221 atatatacat tgtatatata acgtgtatat atacattata tatacactgt agacatacaa
44281 ttgtatacac tgtatagtat atattataca ttgtatatag acatatatac attgtatata
44341 cacatgatat atacaatata taaaatatat gtatatacaa tgtataatat acgtatatat
44401 aacatataat gtaaatgtgt atatatatac acaatgtgta catatctaca ttatacatat
44461 aatattccta tatataaaca atatgtgtat atattatgtt catatatata aacaatgtat
44521 atatataata gattaaaaat cacaagatct gttcaYgcta ccaatttcat gattatttgt
44581 ttatttttaa atttttacaa gtacatagta agtgtatata tttatggggt atatgagata
44641 ttctgataca ggcatacaat taggttattt tgattccttg atgttaatgt aaaaattgtt
44701 tttattgttt tctcctactt gtagttttgc ttcttaaaat gttttcagtg atttttctca
44761 gaatacttaa ttataaataa caatgcaatc aatatgtcac atcaaatcaa ttaaagaacc
44821 tgtaaatgca tttttaaaag tccaggccat tttataatat aataaatttg ttacttcaaa
44881 tctcatttgg actcacagta tgattacata tcttcctatt gaaagaaaat ttcatcttag
44941 aaattaatta taaagtacat caagtgatag agtgaaaacc atttcttgaa ttggtattaa
45001 tctactcaaa tagtaaatca ggaaataaat tctatctgcc agaagatttt tttcagaaac
45061 ggctatctta taaacttcag aaacatgctt tgcatcgtgc tttaattggt ggtttaccat
45121 agcagcaaat aagggaaagg aagtcRgagg cttacctccc caaggaagtc gttggatgaa
45181 aatctatcat aatcccaaac tgtcacctcc agtgttttct tcttgagcta tatagttcaa
45241 atagaaatct aattaaacct atctttccat catacatttt cattacacac atacagtaga
45301 catatttatt tttttcctta aactccttcc atttatgtga aaatacttaa aattttaccg
45361 aaaactatgt agtttaaata ttaaatatta tgtaaaattt gaatgatttt gcactctaaa
45421 ctagtgtttg atcatgggga acattattat tttgtgaata aaatgataat tcttacttat
45481 ttattgtatc cccacctcat tttcaaaaat agaaatcaga atttataaat actctaaata
45541 taagaaattc atagattgca aaaatgtcta gtattatcta gatgaagtat tggattaaat
45601 gtttcagcaa tttccaaaaa acttagtagc attgccttat ttctgcaggt gagtttattt
45661 taaattcaca aacccagatt ataatttata tccagcttca tctttgtaat gaaattaatc
45721 tactagaaga caaattaaga atctcatttt gaaagacagt tcacttgtaa attggtttat
45781 gtgggaactg tctttatagt tttctctctg aattcaacct tatacatttc agttattgtc
45841 tgttaagcaa agatataaaa atgcagattt tcagaaatat aataatgtaa tttttgccta
45901 cagttactta tctStggtga taatccttta tactagtcat cattttgcct tcttctgtag
45961 agattagcac cacaatgcca gattcttagg aggcctcaat ttagcaaaga gatgagatcc
46021 taaaatattg tctagtggag taatacagtt ctatgcactg aatcttattt tttttgtgta
46081 ttgtgtatga aagtcaaaat atagccagtt ggaaaatgtg tttctctctc aaatatgata
46141 aatgtggctt agtctattaa aaattttaaa ttctgaaata acaaatggaa aatattccac
46201 tagttttctt attttatttg tttatgtttt ggctgctttg tcaaaatgtg cacatttact
46261 ttcaccctgt gcttaaatgt cactcatttt tttccattgg ctacatttct tacatgtatt
46321 ttactcaact ttttttgttt gattggcaaa atgtatacag atcccaattt ttgaataatt
46381 gtgttatcac tgtacttata ttagcctaat tctgtcacct agaaataatc ttgacatacc
46441 tgttccatgg aaatactttt ataaattact gtttgattcc actcaggatt aagacttttc
46501 tggacatgtt tagtccttct cttgtactca gcactgaatt gggagaaaag aaagagttat
46561 cttgattatt caccttagtt tatgacttca cagttaaact aaaggacatg cagactattc
46621 aagatatttt atttcaaatc actatataat tatctcatca tcctcatgtc ttaaacctta
46681 gtttaagttg aatgcacagt gacaatttaa aaatatgttg gatgcttgta gttttctttg
46741 ccctWatgat ttttttttaa agaaatgctt gtaggtgttc taaatatact ataatttcag
46801 aaatcttgct cattcctgaa tgtaggagat aattacatga actaaatagt aacatcaatg
46861 ttactgcccc ataaacaata atttggtgtt taaccttact atagttttgt acatacRgaa
46921 aagcaaaact aaaacattgt aatgagtgta ctgagaaaaa gatgaagaat ggctgttgct
46981 gtggctcaca ttccataaac acttgttact gatatctaaa gtatattcca acactcttgg
47041 taaagtatat ttaatgcagt tataaagcaa ttttaattaa atataaattt ttggtttatg
47101 tcaatatgYt attttacaat tgatgaacca aataaaaatc tttcctcaat tattagaact
47161 tgggacatct gcattaatcc ttgactttcc atttcctctg agcaccaatt agaagcttat
47221 atgctacaca tttaaaaaca atttattttc aaagcctatc ctaatgaagt ctggcagaac
47281 atctatagct ggcaccaacc tgctgatggg gttgaaatta gattactgtt acttgctatt
47341 accaaatggt gcccacacag acaaggcctt tctctaactc tcactgcttt tttctgaatt
47401 ttctgcccaa gcttatgtct cacgttctaa ataatacttc atctgtggtg ggcactagag
47461 tcctgtaaac caacctctct gtctgggggt cttgacatgt gtctggattt cacaagttgc
47521 ctttccctaa aagggggctg gaccctgact cttgtaatct gtagttctat tccaaactat
47581 agccagacta actcttgcta cattcctggt ctcaagtatt gccatatcct ggatgcctag
47641 aaattttccc cagccactaa tttacctata cattgtagag aaagctattg aggatcaaac
47701 tccagctcac cactcacttt taaagatggg cctgcaggca agtactttcc ctgtatctct
47761 gattttattt tcttaccagt cagatacaag ggaaataacg ctcaacattg actgcataat
47821 gggatcacct gagttctggt ggtgggaggt gggtcagtca accctccacc cacttccctc
47881 ttgcccctgc ttactccccg aaggaaagtc tgacttgatt agtctgggat gaggcttgag
47941 tattaggatt tttgaaggct cgcaggtgaa tctaatatgt agcgaagatt aagaagcacc
48001 gagttggtgt ttcataacac ttcacaagtc agccattgtg agctgaatcc aactgaagaa
48061 ataaagcagc attcctcgca cttcaaccta tttgaatgta cacaattaag ggcagaattt
48121 gacagctgtc actcaagata aattacaaag aattttaggg aaatatacag acaatgattt
48181 aaagaaagag gagctctcat agactatgga taggaagttt ctatatatac tttttagata
48241 aatttgtcaa tatctagtga agtttaagtt tatataccca aacatccaaa tattcaattt
48301 ctactaattc cacttctgcc atagagaaat tctcctacct gtgaacaaga aatttgttca
48361 agaacattaa ttgcaacatt atttcaatag taagccaata gaagaacgaa taaatacatt
48421 gtgatatatt catttcaatg aaatagtaag tggcactgaa aatcaattaa attttaaaag
48481 cctccatatg tcaagataga tacatcttga aaaaagtttt gatcaaaaac ttaatatggt
48541 atggtataat ggtataaaca taaaatcatg tgaaataagg ttacacatta tatatacatg
48601 tatatatgac atacatatat attaatatcg taagaaaact tgtaaattat gaatattaaa
48661 ttcaatttag tgagtttttt aatggatagg gaagtgattt cagagggctt cagggtatta
48721 tcttttaaaa aatctaaaac aaatatagca aaatcttaaa atttgacaaa attggatagc
48781 aagcacacag gtatttgtta gggtattttc tataattttt agtaaacttg aaatatttta
48841 taatgaaaaa ttcaaaaatt tttagtaaga tatgttcctt taaatttagt tttggattct
48901 ttttttgatg gtgacttaga actaatgact taatttgatg gtgatagaat tagtgtctac
48961 aaaaaagtgt ctacatagaa ataatacata taaattaata catagaaaga gttaataact
49021 ttaatttgat agtgacatag aaagaattag tgacgacttt taagttaata gtaaacttgg
49081 attgctactt tagaatcatg gctattctca taggtgaata tacataggaa acaaacacat
49141 ggtagtatga gttttaaagc ctctgttttg gacttactta tcaaggtggt gaggttatgg
49201 aaaccatatt aagatttata atacactgaa cagtaataaa attatgtttt ttaagttcta
49261 aaaaatacat aatttgttta acaagatggg aattaatatc aaatgcaaac ccatgtacta
49321 tcactaaaat tctgggtctg ccaatacata ttaaaatagt ctgaagtagt attaaaatac
49381 ctttgaaggg atttatcagt cactatcttt tcttaatcca tacatgtgaa taattgttat
49441 tcaaattttt caaatccaca tttagtcttt ttttcactta tacacctagc aaaaattagt
49501 gaatgccaac tctgtatcag gaattgtaga tgtctatcaa ctaaaaaacc cttaattgta
49561 ttgacatatg agtatatatt taattcatgc atgaaaagca tttttaaaag taagcatatt
49621 aaaatcataa ctaacattta ttaaatgcct cctttttcct ctggtaaagt tctaagtgct
49681 tttcatgtgt taactcatgt aatactcata ttaaccccat tatacaggta ttacttctta
49741 ctccatttta taggtgagaa aacttgaagc tcagaaaaat taaggYgtat tgtcaaagtt
49801 gcatagttat taactggacc aggatccaaa cataggtaat ttgatttctt gcttttaaat
49861 aaatgttata tgaactcaat tgattaggcc catcataaaa tgtgacatcc atctattttc
49921 ttaattgcag gcttcactac ctgaagtatc tagtttgtct tctttataat ctaaaattct
49981 ccatctcaat ttaaatacat aatttttata catataatat aaattatgta taatgtgtgt
50041 agacacgcat tataaacatc gtgaacaagt taggccttct ttagagttgc ctagggaaat
50101 tctgaatagt acatccKaag tgagtgttgt ggaacaatta cgcctactta ttgtaaatac
50161 tgatgtttgg ccagatacat ttagaaataa cctaaaYtga ttggacaaaa gttaaaatgt
50221 tcattttaat agagtatctt aatcatagta atgagtttga ttctccaatt ctctccagac
50281 ctaaaacatc ctttagaatt aatgaaagta aaaacagctt gctcctaaac accaatgaaa
50341 gcctttgcag tattttttgc ccttgcattt cctgacatgc agagctggtc acacaaagcc
50401 attcttcaat aacagttgtt ttataactac catgctctga tcatatcata cacaatttca
50461 atgaactgtg ttgccaccta acacaattta aaactctaca caaaatagtc atatcaaaat
50521 ctgtggagtt gaaggtaggc aggKaaacag ggggattctt aaatgtgagc ataaagtcag
50581 gctgagaaat aagtggagtt catcctccct ttcctttctt gtctagtaaa cacactatat
50641 tctcttgtgg gaagattaca ttaatgattt aacattagga caattaggac aattatatct
50701 aataattaaa gaagtttatt aataagggaa aataaaaagg tcaatacata aagatgggac
50761 atggtgctta tcaaaaaata tctaaaactt caccctcttg aagttttgcc ttgtttgttg
50821 gtttgattat ttattttttg agatggagtc ttgctctgtt gctcaggctg gagtgcagtg
50881 caatctcggc tcactacaag ctctgcctcc tgggttcacg ccattctcct gcctcagcct
50941 cctgagtagc tgggactaca gacacccacc accatgcccg gctaattttt tttgtatttt
51001 tagtagagac ggggtttcac catgttagcc cggatggtct tgatctcctg accccatgaa
51061 ccaccctcct tgggctccca aagtgctggt ggtttatttt tttatttgtt tttattggtc
51121 attttgtcat gcataggtat atatactttt aaggctgtct gaaaaaattt ttgaaattca
51181 attattctac tcaagaccag caggaaaaca gtttccatgt acatattttt taatttcaaa
51241 agaaaaactg agaaaagata atgaaatttg aaggcttctt tggtgtatct actttcataa
51301 aattRtctaa aacattgaaa gtattcattt ttaatgattt atctggtttt cctttactaa
51361 acttactaca cacacacaca cacacacaca cacacacaca cacacacaca cgtttttcaa
51421 aattactcct ctgaggttat ttctcttaat ttagaaaaaa tacaacttgc atcccatttt
51481 gtaagctctg tttaatagtg cgatggtgtg cttattgtct atcattttat tttcctcttt
51541 gctctctgat ggcagagact atatggctac attgtcaatt gtaacccctg cacctggcac
51601 agtgtctgac acatagtctg tgctaagtaa atattcagtg atccttagaa catgcttgta
51661 ttttgttttc ctttaaaatc tactgaagta aaataaattt tggacaccat attgtaaata
51721 cacacaccac ctgtacctgc tttccacagg tcccagagga aatagtttga taggatacca
51781 atgttgttta gagaaaggtc cagccaggaa ttgggcttcc aggtataaag atagctaaaa
51841 ataattatat tcataacaaa atctcagtaa tgagaaaata ttttcacttc gctcaacagt
51901 gtgatgagag aaaaccagag cgaggccctt catatatgct catttccatt tcttaattat
51961 ccaacaggaa gtattgagtt cacgcacgac ccagaccttt tcctagtcat tctctcacct
52021 tatcttgcct gacattttgc ccctcaaagt ttgagtatat tgatcagagg gtgggaagaa
52081 aaaaRtaaag gagacaagga aaccaaatca gtgtactttt taactagcta acaggactct
52141 tattttaaat ttaagaatga aagatgtatt acattttaat attaaagaaa agttgtttaa
52201 ttttctatat agtattttaa aataatttag tataattcag aagctcaagc attctgtacc
52261 tttctgttgc agagataacc aaccactggt cgcaaaaaaa tgtatgatac acattgctag
52321 caataataat aacaactact attgattgaa agcttattat gttccagaca ttatgcttat
52381 cacttttgat gtatttattt catgtatttc acagaaggcc tgggaaggga gctgttatta
52441 ttcctatttt gcagaagata aaatagtttt agagaaatct taaagcttct aagtgacagg
52501 gctaaaattc aaacgcaagt tcttaaggac ctcacttatt ggcttccaca gtctaactta
52561 caatgtcagt accttgtcaa tataattccc tcttacattg acaattctca aagacatggt
52621 gaaagtgatt tctagatgaa agatataaga aagtagcttc tagatctttt aaatagttat
52681 ttaagacatg gtattattta taatttataa aatattc~ct cttttataag ttaaatacaa
52741 tctctatcat tctgataatt ttccccaagt ttctatatat aaaagatagg gagattctga
52801 ataatgtgat taataatatc tgttctaaaa ataacactat ttctttgaaa caaaactaat
52861 tttgcatatc agcctgagat acctggattg tgttctgtga tgagagaacc agccataaca
52921 aggaatctat cacagcgtca gttacattgt ttgccataat tatgtggctg taaggaaaca
52981 aaaagtttct gggcaatagc aaggctgtgg taacaaatcc tattgtttga aatatttacg
53041 tatttatgct tttaaaaatc agaaacagcc tcatttggga aacagttcat tcgtagtaaa
53101 tatgtgaaat tttaatgtca tagacaaaaa cgaatgctgt accattaata atctgggtgg
53161 gattaaaatt cccatcaccc tattgctaca gatcatacat gatttgcctt cccaactaaa
53221 tgacacattt aatttataat gcaatgagag atgtgcaaaa taatgctttt ggctatgtac
53281 taagaaattg tcttagttga cagtgtaatg atgcaacttg tcatgagctg tattagaaaa
53341 cgctcctact attgggaaca aaggaagatt aacttattgc taatatacta cagcaagcca
53401 attatggcat cctacattgc atagcagaaa ttttgtgggg cagaagttac aaaggcatga
53461 aaatgtttca acattaggtt caagtgaggg accaagttca aacacctatt atcttttttt
53521 ttNtttgttt gtttgtttgt ttgtttgttt tttgaggctg gagtgcaggg gtgcgatctt
53581 ggctcactgc aagctccacc tcctaggttc acgctatttt cctgcctcag cctcccaagt
53641 agctgggact ataggtgtcc gccaccatgc ctagctaagt ttttgtgttt ttagtagaga
53101 cggggtttca ctgtgttagc taggatggtc tcgatctcct gaccttgtga tctgcccacc
53761 tcggcctccc aaagtcctgg gattacaggc gtgagccacc gtgcctgatg ggatatacac
53821 ctgcactgga catccagaag acScattaat tacttttgaa aaatggctac agatattttt
53881 aatagaagac tcgagaactt aaatcatgat tattatgtga gaagctaaat gagttttagt
53941 gaatagatta tgagacttta gttatgtcta atttcatggt aataatattt ttttcattgt
54001 ttctatgctt ttaatatttt ctacttttct gtgttctatt gcacacatct gctaaagcta
54061 tttagaaata tgctcagaac aatttgtcgc agtgctgatt caatagatac aaacatgtag
54121 aaaaatataa gttacagccc atgttgaagt gccagtgaat gtacataaaa atgccaaaag
54181 tataattcaa gacatagcag cagagcttga cactgaaaga gaaacaactc taccttgcat
54241 tctggacaac catgacttga ctgcattgat tccaagagcg agagtgaagg ggtaaaacag
54301 gaaagtagaa aagacaggaa gaaaatagtt aggaacagaa ataagaaaga aaacatgaaa
54361 ataataacta gaggagetat cccataacat aaatgacatg aggcagaaaa tgctagaact
54421 acagtgaaaa taataccttg caagtgtaat acattccaag gcctttgctt gtctaataat
54481 taggMgtgtg attaaaagaa agacccagga attgaatagg ggtagcttat tagctgcctt
54541 tgagccaaac ctcaccaagt agggacgttt tatttgacaa attgcatgag gatagcttta
54601 ggtggggcat ttgttctcca tttcaccatg gttcccacca ttccttgttg cttaccccag
54661 aatggactga cagattcatg ttacctgcct gtccttcctg gttctttaag tttgtaacat
54721 tctaattgac acatatcctg taataaataa aagatagata ctcccatatt gtgtaaaaga
54781 tgatattcca ggatatcatt agagaatata gaatataaac aacaatgctt tattttcatt
54841 ctttcatttg caaatgctta ttacagacaa atccttggca gtgatttccc cttgtatcat
54901 aatattgtca taaataacat tgaaggtcta ataaatcaaa ggcggaatga agttatcagt
54961 ttgttgttgt tgttagactc taaaagatat tgccaaatta tagttacaac tactatatat
55021 agatataaat gaattaacat aaaacaaaaa ctaccttttc ctatactatg tgactattgg
55081 taatctctac ataaaattat tggtttttca aaatgttcaa taaagtaaaa ctagagcaac
55141 cataccaaca attccaagtt tttaaaataa aattattgag aaggatgaaa ttaaaagctg
55201 tgaactaact ttgatatagc acctggcaat ttaaaaatta ttttctgagt attatctaat
55261 ttggttctcc tgacaagcta aaaatgatga ttctgcctac ctcggctctc agggttgaca
55321 agaatactga atctcaaaga aattggtgat ctgcctgtgg tgatataaat actaagcagc
55381 agattcaagg gcagtgtata gctctaattt ggatcctgtt taaacaaacc aactacagta
55441 aaagaataca cttcatataa ttaaaatgct tttaaatttg ccacagatta ttttatgtcc
55501 tagaaaacag tctattttgg tgaatgctcc atgtgtactt gaagggaata tgtaatttgc
55561 tattgatggg tagtatattc tgtaaatacc aattagatca tcaaaccagc taggaaaata
55621 ttaagaggca accaaacaat tatttgaaaa atttaaaatt atgcttatac gaggtattaa
55681 ggctattttt aaatgagttt tatttttcag aaatatatac taaaatattt gcagaaataa
55741 ttataatagc tgggatttac ttccaagtaa tctggattaa gggagtgtat gaggaaaaga
55801 aacatgattg gtcactaagt gataactgtt gaggctgagt gatgggtaca tggtgtgtca
55861 aattattcct tctacttgtg taccacaatg gaaaatttcc aagttaaaag gaaaattcaa
55921 atatcactcc acaaattaaa atgaaaatga ataaaaaata aaaccagttt ctttaaatta
55981 ccaactcaaa gttcttttta ttttacctcc atttgttgat cttatgtttc catcttgcta
56041 atttggctga tatgaattgc tcaagtgaag gataataatt tgtagggttc aaatcagtgc
56101 tttgaaacta tccttgagta ctgacttata taccagaaca cagcaatttg cattatgtga
56161 aagttaaata tctccaaaga acacttgctt atatcaacaa tttatacatc acacaagaga
56221 ttcaaagaga tattttttat ttatttacca aagtcaatac ttcaaatatc actttgtgct
56281 attttataat ttttaaatca gtgatttgga aatatgtgta taaataagga tacatcaaga
56341 agccacttaa tcaacactaa cataatggaa aatacacatg tcctataaaa ataaacagta
56401 acttgtaagt ccttgaatat tgatttctca gataaatttg ggaaggtaag ccaattcttt
56461 aactttgaca caaataattc cttaaatgat ttcatagtga atctgatagt tatcacagga
56521 gtggtttcca gaattgaaag gctgatttgc tctcttggag gctggtttca ttatgatcac
56581 tgttcttcta caaccctgta aggcttaatt acaagttttt aattccacct tatctactaa
56641 ttggaaataa ataaatatga catgtggagg aaagtaagga aaagataata aagtcaatta
56701 aaatgaggtg tggaaattaa agagtagaaa atactatact attgttttaa agcatgagat
56761 gaagtacttc ttaattttac ttaccctctc cctggaagaa ggtacacttt cacaaaaggg
56821 tcagaataac cattgttgtc tcgaggaaca agatttcttg cttggagaat atgtattatg
56881 agatttccaa gatcatagtt aatttgaagc tttaggagag agaaaaatat tccataagtt
56941 tttaaaagca tgttatacat tatcattcaa tatttactag ttttttttaa agaaaattct
57001 tataagaagc atcaactttc attttcattt tatttgaaac caaacagacc agttaatgtc
57061 taatttaatt gagagctccc aggcatattt taattcctag caaacatgct gttcattctt
57121 tccacagtga aaaggcctgg cctgtttaaa agtttattta gaaggaaaat cataaggtag
57181 aatgctggtt atctttttta attaaattgc tactcttagg aaaatagtaa atgttgttaa
57241 tgtttattaa caacaattcc tagaattttg aaaagaaatt aactaattgg taaattatta
57301 taaagtatta tttgcatttt gccaaataat tagcagtggg gtggaactgt catttaaaga
57361 taaagctgtc agcactgaaa tgtaagaata tttaagaata cacagattat tactttttaa
57421 tgttatatta tctgWtatta aacctataga tacctttcgg taccagcttt cctaatagag
57481 tgagatacta caatactctt tttttctttt aattttagaa gctgaaaaaa gaagagacat
57541 tgctttatag atgcttattg gctgctgcac aattgtggct gaatactaaa agacataatt
57601 caaacaaata tttgagaaaa ctgcRtaatt caaaataatt gagttaagca tttttttctt
57661 ctacaattga aagactcttt tggcatcatt tagaataaag cttaattctg tttgatgtta
57721 cttttgtttg ttaaataata gagtggaagg gatccatatt tcaaagggca aatccatata
57781 gaaagatact aacttttaaa ataatccata taaaacagat atgctgcatt tatatttaaa
57841 ataggataac tcagatgagt catactttcc tgtaaaactt cataatgaaa taaatcctca
57901 ttttagtata attttgatct tattatgttt cctgtcagaa aatacatatt caattgctta
57961 tctccatcca gaaaagacta gagtccctga ccataataaa agcacagtga aaaagaaagc
58021 aaagtaccat taaagaagag gagaaagggg aagtttagaa ctctatgcca tcatgcagca
58081 actgtatgct ataatctggt actgaaatac agaatataaa ataacctgta attaatacca
58141 ctgaaatttc aaacaacttc ctgatcttta tttaaggaga aacacttccc cattctctcc
58201 tttctctgcc agccttagaa tccactttta agtgatgaag cacccaaacc gtttcttatt
58261 gaaatgaaaa cttgcaggcc acccgaagag agtgcttttc aaaatttgct ctgtatggcc
58321 ttagggaaca tctagagtta ctcagggtca gctttgagag agaatgggat gccccagcaa
58381 tcttcaatca cagcgactcc agtgctgata gattcatggt ttggttgtct acataagatt
58441 tcatttgaaa tgagcctttg ctaaaataaa ataataataa taataattga aatcactgcc
58501 ttacgaaaat atcccccaaa ttaagaagga ataatagtag ggtaaatttc aactacagaa
58561 ttacatctta ctccttaagg gaaagcaaaa taaaattaga aaaaacaaca acaataaaaa
58621 caaaaaacac agtccaaaag aaacactagt ccaaggacag aagtttaaaa atagtaggaa
58681 agagaaagaa ggctattaag aatcagaaat tctagcattt tctttgctgt ttgtgaaatg
58741 aagaaagatc aagtcagtga aaaacaggct ttctggaagt tggaaatagc agagaaacag
58801 ccggatctgg agtacagagg tcatcagggt agtactgtta gtttgttctt agtaacStgt
58861 caaccttctg cacattttct ccatttccac gctcacactc cacttctgct ttgtagtagg
58921 ttcctggata atcacttaat tgatttcttt gcctcaatgt cctcccttta taatatttct
58981 tgtaggtcac tgccatatga atttttatta cacattcttt tcaaatagtc tctctcttac
59041 tccaaaatag agatcatggt atattatgta gtggctaaca ttcctaggat tgtgttcaag
59101 tttcttttta atttagtctt aacctacttc tcgaagctga ttcttcaacc attactctcg
59161 gacaacaata cctttaattg tactctttct tctccaggaa cataatctcc ctttctttat
59221 gcttatcttc aaattaattc gagtttctgt tatcctttgt gaagtctttt gtgaaaattt
59281 cctctagaat gtattagaga tgcagctaag actctctttc atctgaaaca tactgttttc
59341 aattagttac tattttatag tgttaattct ttctatatgc tatttcttat ttagtctaaa
59401 ttacttcttg gtatcaccta aggtgcaggt tttaaagttt tatttttact atgacccaca
59461 atcagaaata tataaatatc aaaacacaga gagaatttaa aaagatgatt atctttttat
59521 ttttatatat ttttctttat ctatttttat tttattttcc tgatgaaaat taattttata
59581 agttacaaag cagttatgac ttatgctatg aaaaatactt ctctacaaaa actattcagc
59641 aatttttaaa gcaatttttg attaaaagaa gaaaaaatcc cagtagactc atgaaactct
59701 taaagaggaa acttcaaatt tccaggagaa tctgtcatgt ttaaaataca ttcgacaaat
59761 ataaagtaac tgaggcacaa aacatgttga cactgctaag atatcaggca gatttcaaag
59821 tatagaaata catagctatg attggacttc ataaaacata tatttgtatt aatatactat
59881 tctataaaat tgcatttttc ctttacagtt ctgtatatat tacagaataa gaaaaatcct
59941 aacagtgtgt ttacaatttc aacaaaccag tggcaaaaca accaaaaaag gttatataat
60001 ggcgactttt taaaaaactt catacctgaa tttctcctgt aattggatga gagacaacct
60061 ttgttccatc ggtaggctgt aatattaaag aacatatatt acattaatag atacattttt
60121 cacataattt atcatttcgg cttccttctg aaattagttt ctatttggtc agagcaactg
60181 cttggaaaat atattttatc catttggctg cttcagaata atggtgtcta cttacggttc
60241 tcaatacaca tttaatttta cagatgcata aatctatttt tcattttggt aagccggctt
60301 tgaagctgta attttatacc agcagtattt tcaattactt aagaaaatga acactttagg
60361 tttaaagcac ttaattaaag tatctacagg ttttaaagat ctatacagta atgtttaaaa
60421 tacattcaac aaataaaaga ttggtttaat acaagaactg ccgaggagca cagaaggtag
60481 aaaagtcctt ctttcacttc tttgctgaat gctcagcacc tccctgctcc cttccagagt
60541 gaatcaccca ctcaatcact ttccctataa aaattccaaa gaaattttta tagaactagt
60601 aaaacattcc taaaattcat ttacagccac aaaagaccct aatagccaaa gcaattttRa
60661 gctaaaagaa caaagccaga ggaattatgc tacttgattt caaaatctac tacaaagcta
60721 tagtaatcaa agcagcatgg tatggcWtaa aagcagacag acatatggaa tggaacacaa
60781 tagacaaccc ccaaataaat acattcattt acagtcaatt gactttcagc aaagatgtta
60841 agaacacata atgggcaaag gatagtctct ctaataaatg gtaccaggaa aattggacat
60901 ccacatgcag aggaataaac ttagatcctt atctcacacc atatacaaaa atcatctcaa
60961 aatagattaa agatttaaat ataagacctg aaaatttaaa attattagag agaaacataa
61021 gggaaaagct ctatgacatt ggtctgacca aagatttttt tggagatgac tccgaaagca
61081 caggcaacaa aagcaaaaat aaaaaataga agtacaacaa actaaaagtc ttttgcatag
61141 ccaatcagct tctgctgatt gtttcaatca acagagtgaa gagacaacct atagaatgtg
61201 agaaaatatt tgcaaaccgt acatctgaca gggtgttaat atccaaaata tacaagaaag
61261 tcaaacaact caacagcagg aaaacaaata acctgaatta aaaatgggca gagatttgga
61321 atagacattt ctcagaagaa gacatacaaa ggactaagag gtatataaaa aatcaacatc
61381 attaatcatc agagaaatac aaattaaaac cacaatgaga tatcaactca ccccagtcaa
61441 aatggctgtt atccaaaaga aaaaagatag tgagtgatgg tgagaatgtg gagaaaggga
61501 acccttgtac actgttggtg ggaatgtaaa ttgatatatc cataatggaa aacagtatgg
61561 aggttcctca aaaaaattaa aaatagagct accatatgat ccagcaatct cactgctgag
61621 catatateca aaggaaacga gatcagtatg tcagagatac caacactctc aggttcattg
61681 cagcattatt cacaatagcc cagatatagt accaacctaa gtgtctatca attgatgatt
61741 aggtaacgaa aatgtgttac atatacacaa cagaatatta tttagcctta aaaaacaagg
61801 aagtcctgtc atttgtaaca agatggataa acctgaagga cattatgtta agtggaataa
61861 ttcatgcaca gagagataaa tgccacatta tctcactcat atgtggaatc taacaaagtt
61921 gaacttatag aagcatagag aagaatggta gttaccaggg gctaagagaa aaggaaggat
61981 tggaatgatg gtcaaagggt acaaacttct cttagaagga agtcaaaagc tctgttatac
62041 aacatggtga ctacagttaa tagtaaatgt atatattctt caaaattgtg aagagagtag
62101 atttaaaaaa aattttttta agccaaatat ttcagaggaa tgaagagtag atttcaagtg
62161 ttcggaccac aaaaaaataa gtgaggtaat ccatgttaat tagctcaatg tagccattcc
62221 acaacgtatt catttttttt ttttttttgg agacagagtc tcactctgtc ccctccggct
62281 agagtgcagt ggtgtgatct ctgMtcactg caactccgcc tcccatattc aagtgattct
62341 cccacctcag cctcctgagc agctgggact acaggcatgt gccaccagac ctggctaatt
62401 tttgtatttt ttggtagaga tggggtttca ctgtgttggt tagggtggtc tcgaactcct
62461 ggtctcaagt gctctgcctc tcctggcctc ccaaaatgcg gggattacag gcatgagcca
62521 ccatgccagg ccacaatgta tacatatttt aaaacatcat gctgtacagt ataaacatat
62581 acaagttttg ttaattaaaa ataatttaaa atttaaaaat ctaagcaata ttgcatgaga
62641 tggttaattg cttaatttaa aaagaagttg tcttcaaata tgttcaaatt gtatttttat
62701 aacatagaaa catctacaaa acagaattta gtattaatta tgttggtatt ttagttggct
62761 agtttatgaa ttatttttaa atgattatca aaatagagcc tctataaagt aattattcaa
62821 aattagcaca taattgcttg tggtaaaatg tagttgtgtt aaaatttatt ttaaaattta
62881 gcctaactgc ctttgaaatt actttgctta tgaagctttt ctatatttag tttcaaacaa
62941 atcattttac gatgcaatga ttaaggtcaa cctacttttg ttgtttgctt ctgaataaaa
63001 ggattctttt tttggtgaca tctgctgtat ttttatagtt aaaaaacaaa ctttattttt
63061 tatgtctggt cacttgacct aagcatatac agcctgtcct tcccatatat ctcaccacat
63121 aaagacaaac ctttattcat ttttaaacaa aaggacactt ttttcgcatg tatttatcaa
63181 ctacagggat agtttttctt aagaatcaaa tctatgaggg aaatcataaa ttttgtatat
63241 ttcctctgct ttttataagg ttaaaaaata attttatgct tttttaaatt ccccggcact
63301 ttgaaacaat agcattggaa gcatttgttt cgaatgaaga tttgcatcaa taaaaaaatt
63361 cttaatatgg aattgaggat aaagttcaaa gtagtgataa catgttactg gttttccttg
63421 tttgttattg tcttaaattt tctttatcac tgtgtccttt ttacttttta cttaattata
63481 aaatctaatg taatatgtac cttttgttcc aaaaagatgc aaagctaata ttctatatac
63541 gtatctcaga ttcatgcaac aacaaagaga accagaaaat ataaagtatc agagacattt
63601 ttcaagttcc tcataataac tacKgaaata tttaaaagat gtagaaatac atcatcttga
63661 tacatcttga tcagttttgt actcagaaga gaaaaaatgt ttcttgtttt gatagatcat
63721 ctggaaatga gaaatcataa gaaaaatact ttagaaaatg atattttatt ttctgtctct
63781 atgctgaata aagagctaga aaacaagtgg gtcagaggtc acatcaacaa tcctcacctt
63841 gctgctgccg tgcttctttt tgctcactga gggggaccct ggttgcccag ggctgggaac
63901 ggaactggat cctgctgatg taggacctga atgaacatga gatccttttt caacaactga
63961 tgacagaacc agcggtgact gctgtagtga aaccttctgg agttctgctg ccaactgctt
64021 aggatcaacc cctggggatt tcgccttatc cactacaaca aaatgaaaga gatttacata
64081 cttctccatt tcataggtac tttataccat ggaactatgt gagttctagg tgacaaaggt
64141 aaaacattac ctataaaata agctaaactt taaaaatgaa attaactcta ttgtactttt
64201 atgtatcaat ttctaaggaa gtctacaagg ctctgagaag agtgacataa tgctgaatta
64261 cagaggaata gtgaagttcc cgttgcatct tcagaaaaat gtttttaata ttttacataa
64321 agaattgttt gaatgatgca atatcctatt ttatccattg gaacttaatt tgtatgatta
64381 gctgtttttc cttccttaaa ttttacatag ttctttctct aaggggaaaa ttttctaagg
64441 ggaaaatttt aatgggttta tttatattta caaatgtatt aaaattcgta tagcacttgg
64501 tctattctgc ttagtacaat aacccagact actagaattg tggctgtcag agtaggaagt
64561 gctcaacaaa atttattaaa cataggaaaa agtgatgttt ttaatcttac aatggattta
64621 acaaatttgt agRttatatt tgttattcaa gaaagagtta aatctatctc atcatgtact
64681 tatgaaatta catgttgatt tttgtttact ataaaaaggc aatgaaagag ttcaggaata
64741 attttttcaa aaacccagtt attctaaaaa gaatcaagta cgctctaaaa attatgtaaa
64801 accaaaaWga aatggctcca agcattactt tcacaggatg aattcatatt taaagaatta
64861 aaactgtgaa ctcatgcagc aaggatttta cgtgaacttg tttaagggga ctaacatgca
64921 aatatgtatt tccccagaat gctaacactg tagctacaat gccctagatt ttgtttataa
64981 ttatataaat acataaaaaa atctatccat aactttatat ttgtctatat ctgtgtttNt
65041 gtctacatct tcatctacaa ttacatctgc ctctgcaatt acttctattt ctatctcttt
65101 atttacagtt gaaactagat ttcttttacc taccagcttt tggtggctca tgaagttcca
65161 gatgctggga attttcagaa tctgatagca tattgaggtc cctaaaaatt aaaacaaaac
65221 attaagaaag atattgagga aatctgagac aaagagcact tttttccaac tacccttaat
65281 ttttttcata ggtaaatgag aagtggttaa tgatataaag caactccaaa gcatgcctac
65341 catcctaacc caatatatat ttgcaatgca gttaaaagtc agagctgata aaaatgatta
65401 tttaaggtga aatctttatg aattaaatgt aagttcattt ttaaatacat atccatgaaa
65461 tctaaatggg ttcaggcttt catttaaatg aagcatgttt ccataaaagc atgaaaggga
65521 agaggctgtt gacacaatca gaaactaagt tagctgaatt ctttctatgc tttaggcttt
65581 gattcacttt attttataat tccagaaaat cttgctaact ggcaaaggtt ccaccttaac
65641 aattttaaat taaaagagtc atggatagcc aaaaaatgga aacagaaaga tggggaaaaa
65701 ctcacagtct tacacatatt tctgcttccc cactttgctg actaatgata ctctgaactt
65761 cttcatatgt tttagaagtc aagggaattc cattccattc caatacttgc atccctagaa
65821 agacaaattt gaatataaaa tcaaacgtgt gctatctcta gtctgggtac atatggcatt
65881 gaagacattt atttgcattt agaagtcaac tcagcacacc attttagaga acatcagttc
65941 caagttctct gcaacattaa taccaaaacc attatgtagt ttgatctcat taacttacct
66001 gaacacataa aatatattta atacaacatg caaaattttg cttttgaaaa tctgtgtaat
66061 attatcaaac gcatgcattc tgttcacact gccataaaaa acattattga atatatattg
66121 ctcagaccaa ttttgtatag gaaacaaaca aacaaacaat tagaaacccc aatataattt
66181 tcctgcgggg aacaagctac tagaagaatg tatttggtac tttatcatga aatgggagca
66241 gtagaaaaaa gtcatttgga tttctccatt tcagaaactg ttgtagcttc tattttgtcc
66301 agatgaaaca gaatgccact tcgtgtcttt ttcttcacgg tatgccagac atccctgaat
66361 tgaggaatag caggaatgtt ataggaaggg cagctgcagg ggtctgtgac ctgtgcacta
66421 gtacaaggcc ctgtgctcag aaaggcctat gcttggttta atgctctgct gttgtcatct
66481 tgacattctt agtaacattt gaacaaggaa cccacatttt aattttgcac tgggttttgt
66541 aaattatgta gctggcctgg cctgacctgg tcagggcatt tcatttttcc tctctatcta
66601 gaaagataat ttcatagaaa aaagaaaagt gtaacataat taatatttca atattttaca
66661 tctagctcct ttggtccatt ttatatgacc tgtcaaaatc attgaggggt ccacgtgtgg
66721 catgattcac attgtcctga catgcagcta tgtgaactgg gtacagtaga tgaacccatc
66781 caagatagtg ctcaaatatt tgtgaacttc accagcttta tttgagaaaa atgtctatat
66841 accacaatta tgttgttgaa ccattagtta gttttttttt tttttttttt tttttttaRa
66901 caggtcccac tctgtcgccc agactggagt gcagtggtgt aatctctgct cactgcaagc
66961 tccgccttcc aggttcaagc aattctcctg cctcagcctc ccaagtagct gggattacag
67021 gtgtgcgcca ccacgcctgg ctaatttttg tatttttagt agagacagag tttcaccatg
67081 ttggccaggc tggtctcaaa ctcctaacct caaatgatcc gcctgcctca gcctcccaaa
67141 gtgctgggat tataggcata agccactgtg cctggcctga accattaggt ttttaatgag
67201 cttcacagat gcctatgtga aattacctat tgatcatcat tggctccaat gggaaattct
67261 aaacatggca tgattgtata tttaaaagtt ttgatgatta tgatatatat tagaaagcat
67321 attaccagtt gcaagtaagt aaaggaaaaa cttttacact atagtcaaat ggtaaaagaa
67381 ttccataaaa aggctcacaa taacacaaac aagaatgact tttctataac ttactccaag
67441 gaaactttat cttcagatgg gccttaggtt tatttcaaca atcccaggct gttgtacata
67501 taaaatgaga aaattatgta aaagacagtg acaacaacac taaataaaaa tatagcacgc
67561 tgaaagagga aaataaagca ctttttttaa ataaggagga agagtacatt aataaacaga
67621 tgattttgaa ttcaatcaaa ttaaagttat tatatttcag aaattKcatt gtcacatttc
67681 tgcaggagca catactatga aaaggaatag tcacatattt tcatgctttt tctgttgaat
67741 ttacctgttc attcttcaca tcccaaaata aaagggcaaa tttacaaaac aattatcctg
67801 taaaattaaa aaaatgcttc taaagaacta gtatggttaa taaaatctct taaaaaatta
67861 tacagataac tagggtctcg cctggatata cacctgacac cataaactac atgatctgct
67921 ccataccaca atgcaccaat ggaaattctt tttgcgccac ctcagtttcc caccctagtt
67981 gtttcagtgc tgtagttcaa aagaatggga caattctttt atcattgctt gttgcctaca
68041 gtgagacacc atagggaaga tgaccactga acacagtcat ttaataatat tttccttttc
68101 tattgtctat cttcctacaa attctatgag ccatattaaa ataatgaatg atatacaggt
68161 ataacaaatc gctccttatt tatctcaaaa gaggttctag tagttgtgaa aattaaatat
68221 ggcatttcga atatatatga aaaatatttg ttaattgtaa cattatataa actatttaaa
68281 atgcatgcaa aatttgttga aaattattat gatctgtgga tgttcaataa tgtatcttgt
68341 catttaatag gtttgaatat aagcattttt agtctcaaaa cagcttttca cactgcgttt
68401 tagaaagatt ttctggaaaa tattacccat gtgaattatg atatKtatta tttagtatta
68461 taagtaaaca tttatatttt ctttacattt aaattactac aaatttcagg tatgaaagta
68521 cacagatgag acttaaattc cttgaaagta cctatttaaa tagcttatta ttattaNtat
68581 Ntatttattt tttgagacag ggtcttgcac tatcacccag gctagagtgc agtggcacaa
68641 tcttggctca ctgcaacctc tgccaaccgg gttcaagtga ttctcctgcc ttaggctcct
68701 gagtagctgg gattacaggc acccaccacc acacccagct agtttttgca tttttagtag
68761 agacagggtt tcaccatgtt ggccagcctg gtcttgaact cctgacctca agtgatccac
68821 tgacctcagc ctcccaaagt gctgggatta caggcgtgag ccaccatgcc tggcctttaa
68881 tagcttttaa taggaaatta agacagtctg gaRttttgct gaatatgtag catcgatgat
68941 aggatttgtK gcaaagtctt ttgcttaata ggMtactaaa cactgaaaaa gacaataatt
69001 aggtaattca agaacttagt attaacataa aacattatca aatatatgtt ttcataacct
69061 ctaggattac ttaatattgt atgctcctta aatgggcaaa agctattcct ctctttataa
69121 tacaaaattt catgttattt cttgatctat atttaatatt taccatcaca ttaaaaacat
69181 cttactgact aaaattattc agttagttaa aaatcttaca ggttactcta catccaaaca
69241 tatgccacac aaaagctcct gacgtctgtt cattttattc attccacatg tatttttcta
69301 acacttcata tgtggtaggc actacacaat tcatcacctt tgYttatgtc taacatttta
69361 tggtgttata aaaattaata aaaatgatag tctactagaa aacaattgga aatatctaag
69421 caattagtaa aataaagatc atteacacag gaggaagttc caaaactttt gcaagtatat
69481 gaagaaaacc ccagattcat tagtcattag aaagtgcaaa ttgaagccat aatatattac
69541 ctaactgtca tcatattggg acatatttga aaaccataaa atgctatgtg ttgattggaa
69601 tgtgggattg gtgaccttga gtgactataa atagataaaa caacccctta tttacaattt
69661 attaacatgt aattatttta atgagaatgc acatgagtgc aactgttctg gaaggcaatc
69721 tggcagaatg tagttaaatt aagcatatgc atactctatc acctaaaaat tctttgtggg
69781 tatgtatttg tgaggaggtg gaggtatcaa gagaaatagg cattgagagc attgagagtg
69841 ctgtgaacgc tcacgatgaa aatacttggc agaggctgga agaaacagac cataccaggt
69901 gttaacacca gaaggtggat ccatcctgaa gtctttgcca agttaaaaac aagtgagaaa
69961 caggatctga cctatagggc aatgttattt atgttgattt aaataacacg cgcacaaaat
70021 aaatcattac atattttatg aataaatacc aagcatctca taaattataa tagttgttca
70081 cagaagggag agcagaatgg gaaaataaga tagaggaaaa tgaatgtgtt aataaatgaa
70141 taaagaaatg aaaaaaatgc aggagcagac cttgaaaaaa aacaaaggcc caaacctaat
70201 ttaaaaatgt gtagtataaa ttatttgtaa tttgtttgct atcttttcca tactaagatt
70261 attaatcacg actataggtt aattttccaa atttgaacaa tcactctcag gagtcttcta
70321 taaagcgcta gcagcagcag caaaagatca gctgaacatg gccatctccc ctggcggact
70381 caacagcaaa cacatcttgc aagtggggtt caatacaatt gtccaaatca attatactca
70441 ttgctcattc attttaatgt taggcagtgt taatgtatga gaaagacata gatagagaag
70501 tggattttat tttttaaatt tatatatttt tcatatttta caattttgat ctatttatat
70561 attaacataa aagggggaaa ggtaagaagg atggaagaaa ggaaagaaga aggatcaaag
70621 aaaggaagga gtaaaaagaa aggaaggggg gaatctttgg taaaggaaaa aactagtatt
70681 tgaatagtgt cctgcttatt tacagaacaa ggagatacac tcagtcataa taagagattt
70741 aaactagggt atattttcct gagtatattt attttgaaat atacaataaa ctatttgtaa
70801 tggttaatat tgagtgtcaa cttgattgga ttgaaggatg cagtattgtt cctgggtgtg
70861 tctgtgaggg tgttgccaaa tcagattaac attttagtca atgagctggg agaggctgac
70921 ccaccctcag tctgggtggg taccagctaa tcagctgcca gtgtggctag aataaagcag
70981 gcagaagaag ctggaaagag ccgacctgct gagtcttccg gccttcatct ttctctagtg
71041 atggatgctt cctgccctag aacatcagac tccaagttct ttagcttttg gactcttgga
71101 tgtacaccag tggtttgcca gggactcttg ggcctttggg cactgctggc ttcctacttK
71161 tgaggttttg ggattcgggc tgatccacta ctggtttcct tgctcctcaa cttgcagatg
71221 gcctatcatg cgactttata ttgtgatcgt gagtcaattc tccttaataa actccctttc
71281 atatatacat atatcctatt agtgctatct ctctagagaa ccctgactaa tccactgttg
71341 ttaagtatat tcactctact gtgctattga acactggatc ttatttattc tctccaactg
71401 tatttttgta cccattaacc aacctctttt catgcctcac ttaaaatcct tcccagcctt
71461 tggcaaccat cattttattc tccatctgta tgagatcaac atttttagct cctacatatg
71521 gagtgagaac aygcaatatt ttattttcta tgactggctt atttcatcta acataatgac
71581 ctccaattcc agccctgttg ctgcaaatga tgagatctca ttccttttta tggctgaata
71641 gaattccatg gtgtatacag gtacaatctc tttacccatt tataaaattt tgaagttgaa
71701 aagtgttgtg ttgaagagct aatctcataa taatattgat attttttaaa ttattattgc
71761 tattattttt attttttgta ctcatggttc aaacaaaact taaaatagag cttcaatata
71821 caaaatatat aaaaatgggc ctactttcat caaagcaggc tcaatctgcc ttctagcctc
71881 ctcaccattc tccagatcct attctatggg tacccttaga cacacYctgt ttccctgatg
71941 tacatgagtt gtgagtttaa aataacataa caacctgaat aagggcataa gaacaattgc
72001 tattaactag gacactgttt cttgagatgt actggaagga aggtactctg aatttccgtt
72061 tattgaaaat gaaatcttaa ttggtttaaa aactataatt tttttaaacc caataactat
72121 aggaataagg ctttcaaata gagctctgtg taatatttac cattaaaaat taaaatttgc
72181 ctatctctca ataaacagaa tacacactat ttttatatag ataaatattt tctttatcag
72241 aaatatggtt tatgagccac cttgctgttg gtagctgact gttgacatgt tcttttcacc
72301 ctaattgaat tgtgttcaca tgtagtttgg ttatttacta gttgttgtgc ccttgagcaa
72361 gttggttaat cctccttcat ccttgactcc ctcaagggga ttatacttgc taggtgactg
72421 ctctagtttt atttccatcc tatgatagag aatacaatat gacagaatgg gaaacacaaa
72481 acagctgctt gtttacaact tgtaaatatg cattttttga gctgaaggtt tatataagaa
72541 atttaaaaaa tactttagga tcctaaaact tccattttgt tcttaattat tttccttatc
72601 tatagctgtt cttgacatat acagtaaaac ttccccaagc atagaaatca tgtcatctaa
72661 tttttctttt ttgcacttcc cacatctcct ctcatggccc tctcagtggc agttgtccag
72721 gttctttggc tttgtctttg ctcccctggg tgccaatggt gtccccctta ctgagtttct
72781 tttctctcgg cattgttaca ttgttatatt tgtaacattt ggattggtta actctgcatg
72841 ggacatccaa tctgcagtct gaatctaaat ttggtttaaa tctacatgcc aagcagacaa
72901 atatttatca ttaatgccac taacccaaag ttgatttaaa tgcaaaatac caaaatttta
72961 ctccatcata cacttaaaaa acatgtgata cgtcataatc ttatctcttc ataatataaa
73021 gataatataa ttttaaactc attaaaaatt ttaatgcaaa ttttataaat gaatattctt
73081 tcaaatttta gtagtattaa atatacatac acaggagatt tgcagtatca tcctactctt
73141 ttgctttaag tcactgtatt tttatattga atataaaatg aatgaaacag attgttatgc
73201 aaacttatat gctatgataa tatactctgt ttccattttt gggcaggact gttgacaaga
73261 attctttaga taaatgttat acagcatgga tatcttttta aatcgctcag agttagagaa
73321 ggtaaattct gtatttgaaa ctctcattga tttgggatgt gatcttggac aatttacttt
73381 ccatgtactt tctttcactc tcaaattttg tgaagaacaa gcaattaaaa ttagcaaagt
73441 gtggcttgca tatataaact ccaaaatgaa ataaatttac atatttttaa aacttttcat
73501 cacattttga ataaaagaaa tttaagaaat accaaagact acagttgaat ggtctgagct
73561 gactggtatt tcttttctag gtctgagtac attgaaagta tttagagtca atgacttctt
73621 tactcacata tctaaaatag atttagctcc aatcacaaaa aagtataatt gtaaaataaa
73681 cagattctta cttatatcac agtattaata gttaacaata aaaatattgt tcaaaaggat
73741 ttcatcgtca aatgtgttgt aaaagctcaa gtcacaacca ttttttaggc taatgttata
73801 tagtaagcaa gatacttata agtactgtag ttttaatctg ttatactata tatttaaaaa
73861 gtgacaccta agaggtgata taacttgtct aatatcccac agaatggtag tacagaaata
73921 tgaaccccaa ccatctccta ggccaatgca tgtatcagta aataaaaaaa ctaattcaac
73981 ttatgccaac taagcctaca tgctagccta cctgaaggca aactatgttc aaatatgtga
74041 aacttagcaa aaataacata tattatttgt aatgccattt aaattgcaac ataatatgat
74101 aatttggaaa ttttattaat tgcctacatg ctgatattat ttggaggctt ggacatgcaa
74161 aaactgaaga cattattgaa cgaagagaaa gttgctgtgg gatatatcac ttatggtgag
74221 taaacagtga cagaaatgaa taaaatttga ttgggtctct tatccctttt ccccatctca
74281 ctcccagaag agaagacaat gtcgtatttc tccagggaga ttgatgaaaa attatgctga
74341 atcttactgg gaagaaaaat aatgtaagaa ggatgaaaga ataggaggtg cagattcagt
74401 gctagggagg aaatggtggt tggaggttcc aaaggaagta gggaccagca tcctgcttgt
74461 ttatattgcc tatggaagat gtctggcata ttttttcaat aaaaattgcc aagaggtgcc
74521 tttagaaagt tgaacactag attctgtgac tctcaatgta ggcaaaacta ctcttgtgaa
74581 aacttgggca cagttaaggg agctactcat tatcaggaaa gtgtgctagc tttgacattg
74641 cactcttagt ggcgtggact gatgtacaga ggcccaaact ccagtgttct agaatgtgta
74701 ataccctcac tgggaagttc ctcaaggcat gtggtgcagg aaacaccaaa tgatgaatgc
74761 aattcaattt cctaccaaca gatgaaagaa agattggact tgattacatt tgatttacag
74821 aaaaagtaat atttcttata ctcaaatatg actgttgcaa agatatgctt tttaaacata
74881 cttagtgtga ataagggaat acaattagcc atgatttgtg gaccaacctg ttagaagatt
74941 atcatgataa gattcgattt ctaatcaccg tgaccactaa aacaatccag tccagtattt
75001 ccttgaagga ttggtataga tgccaaaagc cactttatgg ctacagttca ttgtatgtct
75061 cattctatgt gttatttgga acagactgaa tcagaaagtg gctgaatgag gcagaataag
75121 ggatatgagt atattagtat aatttgattg gcccctagaa aataatgtta catggggagt
75181 tatccaataa tagatatgta atgtcatcat ctcacttgaa gtagattgca gtttataagt
75241 ttataacttc ttcctagttt aatatcacaa tttatttgtt agaatgctca gaatggatgt
75301 tttttactaa ctttctaata aaatgatatt aacagattaa tactggtctg ctgtggtttg
75361 aacgcctcct caaaaactca tgttgcaatt taattgccaa tgttatggta ttggggggtg
75421 ggtagggcct ttaagagatg atgaggccaa gccctaatgg atggattaat gccattattt
75481 caggagtggg ttagttatcc caaaagtgag ttccagatac aaaggatgag ttcaacctga
75541 tttccttact ctctctgtgt tgtatgctta cttgaaagag catgcctctt cactatttta
75601 tgacacagca agaaggtcct ctcaagatgc cagcactgtg atcttagact tatcagcctg
75661 aagaacttta agaaatgaat ttcttttctt tataaattac tcagtctctg ctattctctc
75721 atagtagcag aaaacagact aaaatgctat caaatcttat gaataccata atcatttaac
75781 aataacaaac taaaccaata ctatatggat tgtgtagaaa tccacaatta attgaatgga
75841 cttaggaagc tagggtagtt gatgcactta ggaatgagaa atgcttgcct taactgttgc
75901 ctcctctgct ttaagtattc ttactgaatt attaataatt taacttcagt tatgttgata
75961 acctttatga tattcatata ttctgtactg ttctttttta actgttactt aaatgtatct
76021 tactactcag atgatagatt ttaacataaa atatcacttt atactaggaa agtgtctcct
76081 aacaaatata aatgctatct gaactagtgg caaaatcatc atcactgcca ccaccatctc
76141 cactgtacat agatataagg acaatataaa tttcatttta taacataatt tgacagataa
76201 aatacccaga agtttgcata gattactgag gtataacttt aaagcatgtg taaaatgaga
76261 taaaatggaa atcatgtttc tgaaaaagaa agttagaaga aagaaatctc tcaatcaaaa
76321 tttaagagta aaaggaaaat tcaaatatat tcatcctata gtataagaaa ataaaatgtt
76381 tcttttgaca aaggaggaga gaggttttat cacaacccaa atattaaaag tatgcttcac
76441 aagaaataat acaacatggt caattgttat gtataaaaat gttaattaaa gattaatatt
76501 ttaattgaag aggaagaaat acttccaaac tcattgtata aggccagtat taccctgata
76561 ccaaggccag acaaggatgc tacaaaggaa aattacagac cattatccct gatgaacata
76621 gatgcaaaac ttctcaataa aatactaaca tactgaattc aacagcgcat taaaatgatc
76681 atccaccatg atcaagtggg atttatcatt gggatgcaac aaggtttcaa catatggaag
76741 tcaatacacg tgctacacat taaaaaaatg aagaacaaaa agcatatgat catctcaata
76801 aatgtagaaa aagcatttga caaaattcaa catcctctca tgacaaaaaa ctctcaacaa
76861 attgtgtata caaggaatat acctcaaaat gttaaagtcc atgtatgaca aatctgcaac
76921 taatatcata ctcaatgaag aaaagttgaa agtttttctc taagatgttg gtatccattc
76981 tcactaattc catcaacata gtactggaag tcctacccag agcattggga aagaaaaaga
77041 aagaaaatac atctatactg gagaagaaaa ggttaaaatt gtctatttgc agatgacacg
77101 atgttatata tggaaaacag tcaagactcc accaaaatac tgttataatt aataaacaaa
77161 ttcagtaaag ttacaggata taaaatcaac aacaaaaatc agcctatact atactcagct
77221 tatactatgc acttctaaac actgacaaac tatctgaaaa agaaattttg aaatatcata
77281 tatgatagct acaaaaagaa actatttggg aataaattta gccaagaagg tgaaaaatct
77341 atgcactgaa aatgataata ctgatgaaag aaactaaaaa agacacadat aatagaaaaa
77401 atactatgcg cctatggatc agaagactca atattgttaa aatgtccata ctaaccaaag
77461 tgatctgcag attaaatgca atccctacca aaatttcaat gtaatttttc atagaaatag
77521 aaaaaaatct tgaaattcat gtggaaccac aagagatatg gtgtctatgg ggtgaggctt
77581 ggctcctctg aaaaggcagg gaagagtggg aaggattgcg tttggttgtt tgagggccag
77641 ctcagctgca atacaataga acaccaggta gacttctaag atttttgact ctggttcctg
77701 actcctggat ggcacttctg gacccacctg gggcctggtg gacctcacca ccctgaaggg
77761 aaagacaggc ctggctggct ttgccacctg ctaattgtag agttccaggg ctgtgagtga
77821 acataggcaa tagacaggaa gtggttatag caggccttgg gcaagatcca gtgctgtgct
77881 gactttaggt cttacccagt gtagtcacag tgatgttgcc cacaggggtg cttgtgtcac
77941 tcaaccccca gctttaggtg gctcagaaca gagagagaca gacgttatgt ttgggagaaa
78001 gtaagagaag agaacaagag tctctgtctg gtaatccaga gaattctccc agatcttgtg
78061 ctacaccacc aaggttgtac ctttacaagt ctgccagaac cacagcatta ctgggcttgg
78121 ggtgccccct aaagcagaca tagcttagac cataacacca agtcatttga aatatctgga
78181 aagccttccc aaaaggacag ttacaaataa gcccagacag taaagactac agtaaatacc
78241 taagggtctt caatgcccag acaggaaaac atgacctcac ctaatgaact aaataaggca
78301 ccaagaaaca atcctggaga aacaaagata tgtgaccttt tagacaaaga attcaaaata
78361 tttgtgttga ggaaatgcta agaaactcaa gaacacagag aaggaattca gaattctatt
78421 agataaattt aatagagtat gaaataacta aaaggaatca agcagaaatt ctggaggtga
78481 aaaatgcaat agatgcaact gaataatgca tcagaggtct ttaatagaag aattgatcaa
78541 gcaaaagaaa ggattagtga gcttgaatac aggctatttt aacgtacacc aagaagacaa
78601 aaaaagagag aattttaaaa ataaagcaca cctacaggat ctaggaaacg cctcaaaagg
78661 gcaaatctaa tagttattgg ccttaaagag gaagtagagg aagagattgg ggtagaaagt
78721 ttattcaaag ggataatgac agagaatgtc ccaaacctag agaaatatat caatatccaa
78781 gaacaagaag gttttagagg gccaagcaga tttaacccaa agacaactac ctaaaggcat
78841 ttaataatca aactcccaaa ggtcaaggat aaagcagcaa gagaaaaaaa aataacatac
78901 aatacagctc caatacatct ggtagcagac ttttcagtgg aaaccttacg ggccagggag
78961 agtgatatga cttatttaaa atgctgaaga aaaaaatctt ttacgttaga atagtatgtc
79021 tggtaaaaat acccttcaaa catgaaggag aaataaatac ttaacccaga caaaaaaaag
79081 ctgagggatt tcaataccag agctgtccta caagagatgc taaagggggt acacttcaat
79141 cacaaagaaa aggacagtaa tgagcaataa ataatcacct gatggtccaa aattcattgg
79201 taatagtatg tacacagaga aacacatatt attataacgc tgtaactgta gtttgtaaac
79261 tactcttatc ctaggtagaa gattaaatga tgaaccaatc aaaaataata actacaacaa
79321 cttttcaaga catagcataa taagatataa atagaaacaa caaaaagtta aaaagtgggg
79381 ggatgaaatt aaggcataga gtttttatta gttttctttt tgcttgtttg tttatgcaaa
79441 tagtgttaag ttattatcag gttaaaataa tgggttataa gatagtattt gcaagcctca
79501 aggtaacctc aaaccaaaaa gcatatgata tatacgcaaa aaataaaaag caaaaactaa
79561 attatatcac tagagaaaat catcttcact agaggaaaac aggaaggaaa gaaaggagga
79621 agagaagacc agaaaataaa caacaaaatg gcaggagtag gctctaactt atcagtaata
79681 acattgaatg taaatggact aaacacttcg atcaaaagat atagagtggc tgaatgggtg
79741 aataaacaag acccattgtt ctgttgccta caagaaatac acttaacctg taaagacaca
79801 catagactga aaataaaggg agggatgaag atatttcatg ccaatgtaaa ccaaaaatgg
79861 gaacctagaa attaataaca ggaggaattt tggaaactat tcaagtacat ggagttatta
79921 cacttagaaa aagtagattc caagacaaaa gctataagaa gagacaaaga agttcactat
79981 ataatgataa agaggtcaat tcagcaagag aatataacaa ttgtaaatat atatgcaccc
80041 aacactggat tacccagata tgtaagggaa atattgttag agctaaagag agaggtaggc
80101 tccattacaa taatagctgg agacttcaaa accccatttt cagcagaaaa tcagacaaag
80161 aaacatgaga cttaatctac actatagacc aaatggatcc aatagatatt tatagaacat
80221 ttcagccaag agctgcggaa tacacattct tttcctcagc acatggatca ttctcaagga
80281 tagaccacat gttaggtcac aaaacaagtt ttaaaacatt caaataatgg aaatcaccaa
80341 gtattttctc ttactacaat gaaataaatc tagaaataac cagaggaatt ttggaaagta
80401 ttcaaatata cagaaattaa acaatatgct cctgaatgac cagtggatca ataaagaaat
80461 ttagaaattg taaaatttct tgaaacaaac gataatggaa acacatacta aaacccatgc
80521 aaaagcagta ctgagaggga agtttatagc tataagtgtc taaatcaaaa agagaaaaaa
80581 gttgaaatga aaaatctaat gacgcatctt aaagaactag aaaagcaaga gcaaaccaaa
80641 ccccaaatta gtagaagaaa acaaataata aagaacagag tggaaataaa tgaaatcaaa
80701 atgataaaaa tacaaaagct caacaaaacc aaaaattggt tttttgaaac agatatatga
80761 aaaggtgctt aacatcattg atcatcagag aaatgaaaat caaaactaca acaaaatata
80821 atttcacccc agttaaaatg gcttatgtcc aaaagacagg caataacaaa tgctgatgag
80881 gatgtggaga aaagagaacc cttgttcact gttggtggga atgtaaattg ctacagtcaa
80941 tatgcagaag agtttggagg ttcctcacaa aactaaacat tgatttatca tatgaaccca
81001 caatcctact gctgggtata tatccaaaag aagggaaatc agtttattga ggagatatct
81061 gcactcctat atttattgct acactgttta caacagctaa gaattggaag caaccagagc
81121 aagactctgc ctcaaaaaaa aaaaaaaaaa aaaagaattg gaagcaacct aactgtccat
81181 caacagatga atgaataaag aaaaggtgac atatacacaa tggggtacta ttcagccata
81241 aaaaagaaca agatccagtc atttgtaaca acatggatgg aactggagat catcatgtta
81301 tgtgaaataa gccaggcaca gaagacaaac atcgcatgtt ctcgattatt tgtgggatct
81361 aaaaatcaaa actattgaac tcatggatat agagagtaga aggatggtta ctagaggttg
81421 gaaatagtag tagggagttg gagggaaggt ggggatggtt aaagggtaca aaaaatagaa
81481 taaataagac ctgctattcg atggcacaat agtgtgacta tagtcaataa taacttaatt
81541 gtacatttca aaataaccta atgagtataa atgtattgtt tgtaactcaa aggataaatg
81601 cttgagggca tggataccct attctccatg atgtgtttgt ttatctttgc atgcctgtat
81661 gaaaacatct catgtacctc ataaatatat atacctacta tttatccaaa aaattaaaaa
81721 ttaaaaagtt atactttgct tactttgctt atattggagt caattatact acatgattat
81781 tatgaatgat ataatcaaaa ttaaaagggt aaagttgatg cacaatttct ttcataatta
81841 gaagtgtcaa aagatgtaaa taacatagag aagtcagttc aaacaacaaa aatatcagta
81901 acaattttat catcctgaga gaatcttcaa agaaataaaa ttatgtgtca agttatttca
81961 taaaaagtgc aaatattctg ttctttatat cacaatgaag aattagcaaa taattcactt
82021 tgacttggta gatgtttaat aaataacata aaaaatcaaa tgtcatttga tccctgaatt
82081 ccatttgaaa agttatcaat ctctttaata aatagaattc aatttcaaat gttatcaatg
82141 ttagagtgta tacaatatcc tgcaataatt gattttccat tgaaaaataa gaattgacta
82201 agaagaaaac agtttaacag caatttctgc caactgaata gaataaaact taactatgtt
82261 ccctccagct ttctaatatt catgtagaga aattctttct ctaattgtaa ataggattac
82321 aactgtaaaa gtaatggcaa tatagttcta tatgaattat agagggtttt catatgtata
82381 ccatctgatt ggtggttatt tcagttaaaa ggagtaaaat ttaacccatt tcacttgtgg
82441 taataccttc ggtattaata aggagcacca atacaggact cacacaaaaa agttattttg
82501 cccatttttt ttctcatttt atcttcacag caatccagta aaatagatag ggtaagcaaa
82561 tccccatttt cacaataaaa cccccatagt tttagaaacc acatttggtg gcagtttgaa
82621 aagccaggtc tcctcattcc tcatctaagt tattttggta ttataaaggt ttttttaatt
82681 tttaagttat acagaatatc taattataaa cttctggcta ttttatagct aatatcttag
82741 atgtaagtgc ataatcagta taaataaata tattgaatta caataaaaca tcacatcaag
82801 tccacaaata tttagtcagt aagtgccaaa gagaatacta aattctgggc cacttatatc
82861 aattagttat aatttctgac atgattactc ctactatgga gtaggaacat catgaacaaa
82921 tgctcacaga aggcaaataa catcatggat ctgggatcag agtggggctg gtgggtgtat
82981 agatgggagg tgagaatgga taaagatgag tttgtatagc tggaatgtgt tgtggaaggc
83041 ttacagctaa aattttattt ggacttaatt aattttctaa tattaagaca taaaaggaaa
83101 ggtttataat aattagatca ttattttaaa aacatcttgc catttggaga ggatgtatgc
83161 atttctcctc caacttcagc aggttagttt cagtttcttt tgtgttttct ctgtttcttg
83221 tacacacttc tgttatcctc aaaacgttat actttaattt attcagttat gtaattgcct
83281 ctattttgac aatggagaca ctagtgaatg acaatttgct gaatgaatga atggataaaa
83341 tcagagagac tggaagcccg gagaatggtt aagatttaaa aaaaataaga caggaattca
83401 aaattgcaat tgattattaa ttcttacatg aaataaaatt ttcagaaaat attgtcatga
83461 tgaaaaaata ggactgctga gaatcagttc ttggaatcaa tatagtactt aaattcattt
83521 tttccacagt ttattaatgc aaactgtcta agcactctaa aRtattgaga gattttattc
83581 acctttgttc tcataaataa agtgatattg atacagccat aattttctta aataaagaag
83641 tattacagaa tgattttcct tcataaacat taaaactgtg gctcttggct gccttttgtc
83701 ctactgagat gcaaattaca aatgatagaa ataaaaaaaa aaattgaact gccacctgta
83761 gaaccacaca aatgccgggc atggcggctt acacctggag tcccagcact ttgggaggcc
83821 aaggtgggca gatcacctga gatcaggagt tcgagaccag cctgaccaac atggtgaaac
83881 cccgcatcta ctaaaaatac aaaaagtagc caggcatggt ggccagcgac tgtaatccca
83941 gctactcagg aggctgaggc aggagaatca cYtgaaccag ggaggcagac agtgcagtga
84001 gctgagatcg cgccattgca ctccagcctg ggcgacagag caagatgccg tctcagaaaa
84061 aacaaacaaa caaacaaaca aaaaacMcac aaatatacat ttatatggta tatttcctac
84121 taaaatatat ggatttattg tgttaattta aaataagatg caagacttag atacaaaata
84181 ctctgttggc ttgctgtatt atgcagggat ttaagttttt aaaaaatggt gaagggattt
84241 tggcttataa atatgaatac ctaataaatg aatgaacata ttgagatcat tttcattaac
84301 taaattaaat acacatattg tgttgataca tatgtatatc tattatacat atatataact
84361 atttcttaac acctccctgt tcccaccttg gtcttaactt acataggttc ttaccaactc
84421 tccttgcttc tactctttac ctctttaaaa ctattcttaa tacagcagta agagtgatcc
84481 tatttaaacg tcattcagct tatgtcaggt caattgcgtc tcatctcaca taagtacacg
84541 ttaaagtcct tacaatggcc tgcaagattt gacccctgct acttttggta tccgctcttt
84601 cacgtgttca ctcagtttca gccacgttgg cttcctttct gtcttgctgt tcttggcaca
84661 caacaagcat gctcttgctc aggatatttg tgtccttgtc acttctctgc ctataatgca
84721 agacaactcc cagatcattc tttcccctcc ttggtggctt tactgaattt ttgcctactt
84781 gccaaagctt tctcttacca cctcacctca aattgcaacc acatcctcct acgtgccata
84841 cccaccctcc ttgctatatt tttctcctta gcgtttatta tcgtctaata tatgatactt
84901 aatatattat atgagatata tttaacattt atatatgata ttaatatttg ttataatctg
84961 tcttagctat tagaatgtaa gacccatgct ttcttcactg aagccctcac atgtccaaga
85021 agagaaatta ctttatacaa tatgtactaa aaaaaacttt gaaaaaatga atgaataaat
85081 aatggcattc agcaaactca agtgctgtgg ctgacagtga ctacgatttg gggaatgagt
85141 agagtgtaaa aggaaacaaa agtagcttaa gagaaaaata aaggaatctt attttccttc
85201 actactctca atgaaatttt atacacacac acacacacac acacacacac acacacacac
85261 acaccccttt aatatgaatt tcttgaggac tgaagtaaaa acctgcattc ttgtaggcta
85321 ttgtttccac ttcggcactt atcattgtat ctggaatagt actccataac tatgctgaac
85381 tattaaaaat taattaaaat aaatgagaac cttaaaagat ctgtatagtt cctggacagt
85441 gtcttgccct caggagctta tagtctgctc ttagaaacta cctgaaggtt agttggaatt
85501 ctttcgagtg ggggaaaaat ctgtaagctc catttagtca tggtgttggt tctaatgcaa
85561 gcagagtcaa ccaatgtatt ctgcatttct ttatttctgt attttctttc aatgaaacta
85621 aaagaataca tatatcaaaa ttaaaaggaa gacaaacatc attaatttta aaaaaagagt
85681 tttggtccag gtgcagcggc tcaggccttt aatcccagaa ctttgggagg ctgatgcagg
85741 aggatcgttt gagcacagaa ggtcaaggct agcctgggca acatggcaac actcctgtct
85801 ctacaaaaaa tttaaaagaa ttagcatatg tggtagtgca tgccttttta ctacttacaa
85861 tattctaagc atgacattat gtttcctata tcttattcct aaatttgata acaattttgc
85921 caactattat cccWgttatc cagctaagaa cacctgggta ctaaaagttt taaaaaatcc
85981 aggcaataag taccagatct gaatttaaat cctgatctaa ctctaaaagc atggctgtct
86041 acaaaccact ggagatacta aagcattggc tggtggaaga tctggtatgg atattaaaaa
86101 gagaggttag catccttgct tccaaagtaa ccactccaag cttacgaaaa agtgcagtct
86161 attccaagaa atattggtta gacaaatccg gaaatctaac tgtaggaaca attgttcctt
86221 atgaagcaat atcactgaac acagaaatac ctcaaagtat gtcaaccttg atgaaggcaa
86281 tcaaattagg atttggggca ttgtaccaca taaaacagga cattatttag tttccttcat
86341 gtccctatca caaagattat aatgtaagca taattctcct ctgataaatt tcaaaataaa
86401 tggataaaga agagaaatat gtttctttgt actggcaatg tatctaatca ctagtatcgt
86461 gatgtggtgt gatatcacta catcttgaaa ataatatatt agaacctatc agcccaggga
86521 ccagtaattt gtatttttct tcacagaaga gagtttccta aatatatatt agaaaatctt
86581 catatcaaca tgaWatgtgg tctgtgtcat gtgtacctaa cgcaccagct ttaaggaatt
86641 ttgagaaatc tcatgctaat gaccaatccg tacctggtaa tccccctgga acaagaacaa
86701 ggaagctcac tcatctgtgt gctgtgtttc ttgatctcca accttgatca ctgccatgcc
86761 atctgtaaca tatgccaaaa aagcataagc agaaatagag actttcttgc ctaggagcat
86821 tcttccttat gttatgctgg agtgcgtcct ctgtcctcta gtaatgctac tggaattagc
86881 tcttctacca aagacttttt catgacaagg aattccagag gccaacttct aaaatcaaaa
86941 ccaccactcc aaaaacagct aatttcatcc ttacttcaat ccctgattct cagcattaca
87001 tccaacagca ttttcttgcc agaaaccctg tcagttcatc tttaagaaga agagcaagct
87061 agctggacca atttcactca cctactctga aacaactaaa aactaagaat ataaaagtat
87121 gcatgaacta taattcatgt cacagaggca tttcctcaca gaatacctat ggacaaacaa
87181 tgaagtttct ctcatttcat tacaagtctt atggccttgg acgtgcttac ttgccatgta
87241 gctctggcta aatctataag caaacatagg atatcactgg ttttagcttt gtgctcttcc
87301 atgctgtgtt accactgatt cattaagaat gttcttgaag acacattcag attttaatgt
87361 tatatttcta tcttagctcc aaagagtttt acaaaaattt tctaaattta tcaattataa
87421 taatatagat acaagttatc ttcaaaagat tttattaaat taacaaagtt gaacaactta
87481 tcaatataaa caattgtttt aggttcattg gatatatgat atttagtcct tgtggattca
87541 ttgttctctt acaaaaattg ctgaagtttt aaaagtatca cgatggtaat gtatttcaca
87601 attatgttat aacacagaca actaggatga aaattaattt ggagaactag ttcaaaaaat
87661 ccagtgatta aataaagctt agaaccaatg atatgtatat aaaagtttag atttagtcca
87721 tgatattaac caagtaaaat tgattttatc tatattttct actctacctt ttctggagat
87781 ataatattgg cataaattga taaaaccata taatattgtt aataagttta acaattgcta
87841 tggataattg ttttaatgtc ctaactcttg ttattgtatt aattcagaat acaatgacta
87901 agtctctaag tagagcaaaa acctgcattg tgaacttatt gaagactcaa ctggacatga
87961 ttatatgtct aatttttttc caaattaatc agtctcttca atgaaattac tatcaaatct
88021 caacagagat tgtcatgaaa attgaaaaac agattccaga atttatatgc aaaaccaaag
88081 ggtcaagaat tgttccgaga gcatcctgac aaacggctct aggatggatc cacctacgaa
88141 atgccaggat ttaatataaa gatgttacaa ttaaaacagt gtgatatcgg tgtagggata
88201 gaaaaataga ccagaacaga gaacctggaa aagatctgtg catgcctttt aaaacttaat
88261 atatgacaga tgggactagc agatcagtgt gagtaataat acactattca aaaaatggtg
88321 cacagtagta gtaaagaaaa ataagaaagc aatcctattt aaaacagcta cagtataatg
88381 aaatacctaa gaataaattt aactaaataa atgaaagatc tttacaatgg aaactataaa
88441 acatgaaata tcttttcatt cttatgtgtc ctcttcaatt ttttcaatgg ataaaaaata
88501 gaaaggacac ataaaaaatg gaaagatatt tcatgttcat ggattgaaaa aattaatatt
88561 gttaaatgtc cacactatgc aaaatgatct gcagattcaa tgcaatctct atcaaaatat
88621 caatcaatgt cattcttcac agaaatacaa aaaaatttct aatagttgag tggaaccaca
88681 aaaggccctg aatagacaaa gcaatcttaa gtgaaaagaa caaagctgga ggcatcacac
88741 tgcctggctt caaaatatac tacaatggta tactaaccaa aagagcatgg catggcataa
88801 aaatagacac atagactaat ggaacagaat acagaaccca gaaataagta catgcattta
88861 cagccaacac agtttcaaca aaggcacaaa gaatatacgc tggcaaaagg atagtctttt
88921 taagaaatgg tgctgacaaa actggatatt catatgcaga agattaaaat tagagcatta
88981 tctcttacat atcaaaataa actctaaatg aactaaagac ttaaatttaa gacctgagct
89041 tatgaaacta ctagaagaaa aacattaaaa gaatactcca ggacattggt atgggcaaaa
89101 atgttttgag taagacctca aaagcacaag caacaaaagc aaaatttgac aaatgggatt
89161 acgtcaacct aaaaagcttc tgcatggcaa aggaaacaat caacaaagtg aagagacaac
89221 ctacagaatg ggagaaaata tttgcaaact atccatctga caagggatga ataggtagaa
89281 tgtataagga actcaaacaa cttaatagca aaaaaaaccc caaataattt gatttaaaaa
89341 atgagcaaaa gatctgaata tacatttctc aaaagaagac atacaaatgg ccaacagata
89401 cattaaaatg ctcaatatca ctagtcatca gggaaatcca aattaaaacc acaRtgagat
89461 ttcacctcac cccattaaaa atggctcttt tcaaaataga gatgctggca aggagatgag
89521 aatagcagat gctggcaaag acttgaagaa agagaaatgc tcatacactg tttgtggcca
89581 tgtaaattag tccaaccact ataaaaaaca gtatggagat tcctcaaaaa accaaaaata
89641 gaactaccat acaatacact gatcccactg ctaggtatat atcaaaagaa aggaaataag

Following is a REPS2 genomic nucleotide sequence (SEQ ID NO: 7).

>X:16315151-16528450
1      ctctgtcacc caggctggag tgcagtggtg ccatctcagc tcactgtagc cttgacctcc
61     caggctcaag tgatcttccc acctcagcct cccaagtagt tgggactaca ggagcacacc
121    accatgcctc gctaattttt gtagttttta taaagatgag aactcgctat gttgcccagg
181    ctggtctcga actcctgggc tcaagcaatc catcggcctt ggYctcccaa agtgctggga
241    ttacaggtca ccatgccagg ctgagacagt aacttgtaag atttaattgt tggtcgggtg
301    cagtggctca cccatgtaat cccagcactt tgggaggctg aggcaggtgg atcatgaggt
361    caggagttca agaccagtct gaccaacatg gtgaaactct gtctctatca aaaatacaaa
421    aattagctgg gcgctgtggc gggtgcctgt aatctcagct actcgggagg ctgaggcagg
481    agaattgctt gaacctgggt ggcagaggtt gcagtgagcc gagatcatgc cacggcactc
541    cagcctgggt gacagagtga gactctgtct caaaaaacaa acaaaaaaag atttaattgt
601    cattagtggt ttgtggggca cataagggtt caagaacttt aacccctgtc tttcttgatg
661    agtttagaac tacctgggta aggtccatgt gcacatcaac cttgttgttg ctagacttgg
721    gttggagatg atgattagga ttgcagccac actcaggcta cttcttacat attctatccc
781    cttacttccY ccacctcaga gtctataaaa cagacctata cctgggaagc tgcWaggaaa
841    ttgctgtctt ctaatcatca agtcctgcag gtggtaacag agaggaccca aattacgtgt
901    gctttctaga tggaatcggg gttagagtgg gggtagagtg gagtcccctc tgagggcaac
961    agaattcaga ggtggtagta ggagagggag gtaggagaga gagaaagaaa gagacagaga
1021   gagagagaga aagaatatta gcctgttctc acactgctaa taaagacata cctgagactg
1081   gataattcat aaaggaaaga ggtttaattg actcacagtt tcacatggct ggggaggcct
1141   cacaatcatg gcagaagttg aaggagRagc ataggcacgt cttacgtggc agcaggcaag
1201   agagcttgtg taggggaact gctctttata aaaccatcag atctcatgag acttaatcac
1261   tatcatgaga agagcatggg aaagactcac ccccataatt caattacccc ccaccaggtc
1321   cctcccatga cacgtgggaa ttatgggagc tagaattcaa gatgagattt gRgtggggac
1381   acagacaaac catatcatgg aggaaaagag agggggagag agacagagag agagagaatg
1441   aaccaagaat gatcaatttc ttctcccttt catcacttct ctttccttag agaagagtga
1501   gggggactag gagaagtgcc aatgttactt catcaatatt ccttcctgag gagtagagag
1561   gaagctttct catgaaaata atgaggccag gggaatagga ttctctctca cactgttaaa
1621   gatctgcctt ttttcactaa tagcagaaaa aaatattaaa atcattcaaa caggtgatta
1681   tttagtgttt atattggtcc atcccttaat aaataccttt caaaattcac caatctttga
1741   gatacactca atagtacagt catgcgttac ccaatgacgg gtatgttctg agaaacacgt
1801   tgttgggtgt cttcgttgtt gtgtgaacat cacagggtgt acttacacaa atctagatgg
1861   tacagcctac tacacaccta ggctatgtga aaattgtcag aatcaaaatg gagtcgcttg
1921   tgttaaaaaa aaacacacaa aaacctgaca aatagagctg aggaaggcta cgaagagagg
1981   gttctcacac ttgtatgcct gataacaaaa ttgcaacaaa agactgcaaa aactgcaaac
2041   ttacacaaat gtcatcacaa ccttctgtaa agacatctga ccagcaactg cctgtctaaa
2101   cttgaactgg tgccatcctt gttattgatc cttgtcacca aaaataacca tttcaaaaca
2161   actatgtaac cttcattttt ccttgaaaaa tttttgtctt cctttacctc cacgaatatg
2221   cacaagttta ctgtggcata catattccca ttgcaatgcc ctattcccac atgaacaaca
2281   ttttcttttc ttttttcttc ttcttttttt tttttcttta gacagagtct ccctctgttg
2341   ctcaggctga gtgcagtggt acaatcacga cttactgcag cctcagcatc ctgggctcaa
2401   gtgatcctcc cacctcaggt tcccaagtag ctaggactac aggtgcaYga cacaatgccc
2461   cacacccagc taatttttgt atttttttgt agagacaggg ctttgccatg ctgcccaggc
2521   tggtcgtcaa ctcctgggct caaatgatcc acccacgttg gcctcccaaa gcactagcat
2581   tgcaggcatg agccaccgtg cctggccata aacatcattt tcttttagag agcctctctc
2641   tgacatttaa gttgacagct atatggtaca gcctattgat cctagactac aaacctgcaa
2701   gcacagcatg attgtattag tcaattctca cactgctgta aagaaatgcc tgagactggg
2761   taatttataa agaaaagagg tttaataggc tcatggtttt gcaggctgta cgggcagcat
2821   ctcttctggg aaggcctcat ggagctttta ctcattgtgg aagacaaagt gggagcaggc
2881   atcttacatg gcagaagcag gactgagagg ggttgtgggg aggtgccaca cacttttaaa
2941   ccaccagatc tcatgagaac tcactcacca tcgtgagaac agcaacgagt ggaaggggct
3001   aaaccattca tgaaggatcc acccccatga tccaatcatc tcccaccagg ccccacttcc
3061   aacactgagg attataattg agcatgagat ttggatgggg acacagagec aaaccatatc
3121   attttgcccc tagcacatcc taaatctgat gtccttctca ccttgcaaaa tcccatcatg
3181   ccttctgaat agtccctgaa aatcttaatt cattccagca ttaactcaaa agtccaatgt
3241   tcaaagtctc atttgaggca aggctagtcc cttctaccta tgagcctgta aaataaaaaa
3301   caagttagtt acttctgaga cacaatggag agataggtat tgggaaaata tacccattca
3361   aaaaaaaaga aattggacaa aagaaagggg ctacaggcct catgcaagtt tgaaacccag
3421   cagggcagtc attaaatctt aaagctccaa actaatctcc tttgacacca cgtcttgtat
3481   ccaggacaca ctggtgcaag aggtgggctc ctaaggcttt gggtagctcc acccctgtgg
3541   ctttgcaggg ttcagccccc atgacagctc tcatgggctg gcattgagtg cttgtgcctc
3601   ttccaggtgc agggtgcaag ctgttggtgg atctaccatt ctggggtctg gaggatggtg
3661   accctcttct tacagctcca ctaagcagtg ccccagtggg gattctgtgt gggggcttca
3721   accccacatt tcccactctg cactgcccta gtagaggttc tccatgaggg ctctgcctct
3781   gcagcagtct tctgcctgga atccaggctt ttccatacat cctctgaaat ctaggtggag
3841   gctcccaagc ctcaaccctt gcactctgca cacctgtagg cttaacacga ggtggaagca
3901   gccaaggctt gtggcttcta ccctctgaag cagtggtctg agctgtacct gggccccttt
3961   gagccagggc tggagcaaga gcagcttgga tgcaggaagc aatggcccaa gggtgcacag
4021   ggtggcaggg ccctaggcct ggctcaggaa acctttcttc cttcctaggc ctctgggtct
4081   gtgatgggag aggctgcaat gagggtctct gaaattcctt tgaggccttc tccccattgt
4141   cttaggtgtt agcacttggc tcctttttac gtatgcaaat ttctgcagcc tgctttaatt
4201   cctcccctga aaatgggctt ttcttttcta ccacatggcc aggctgcaaa tttttcaaac
4261   ttttacactc cgcttccctt ttaaatgtaa gttccagttt caggtcattt ctttgctcac
4321   atatatgaac ataggctgtt agaagcagcc aggccatatc ttgaacctta gaaatgtctt
4381   ctgccagata ccctaaatca tctctctcaa gttcaaagtt ccacagatcc ctagggcagg
4441   ggcacaatac aacaaagctc tttgccaaaa tgtaacaaga gtagcctttg ctccagttcc
4501   cagtaagttc cttatttcca tctgagacct catcagcctg gccttcattg tccatatcac
4561   tattagcatt ttagtcataa ccattcagtc agtctctagg aagttccaaa ctttcccaca
4621   tcttcctgtc ttcttctgag ccctccacac ttttccaatc tctgcacgtt acccagttcc
4681   aaggtcactt tcacattttc aggtatcttt atagcaatgc tccactccta agtaccaatt
4741   ttctggaaaa aaaaaaaaaa accaaacaaa aaaaacataa tgtaaagaat atctctgcaa
4801   tgggaataat tggattccat gagaaacaat aaaaaagaat atctcttgat gtctcttggc
4861   tatttctgaa aatatgatcc ttctggcttt tctggccatc atggagccaa aacaagtgtg
4921   taagctttga accacaaaaa agttcttgtt tactgtcagc cttaagggat atgagtgctt
4981   ctagtttcta aattcttatc tgtgtttatt ttgaagtttg ataactattt cttctattga
5041   aaaaactttt agaaataaag aacagtactt ggcattcctt agatattaac atatttttac
5101   aagtgccatt tttttttcct cctgtgccct gggtattact gctgttgggt cccctttggc
5161   tgtgccccac atcttttgtt gagcagcttc tttcttacat cctggagacc ttcagagctt
5221   ccctttcttc tgacccagcc tgctgtccct cactcattat ttccaggttg ccaagtctct
5281   ggggctcctc Yctttctgtc gtgtcctttt acctccccag ttccacccac tctcagtcaa
5341   cagccatctc agccccactg atcaagcctt cctggctgag ctctggctca tgaattttct
5401   ctcttgtttc aactcccatg gcagttaacc cagagtatac agtttagcac ttaattgtat
5461   attttctttc atttattttt atttgttgtg ttagttttgt ctcttccagt gaggcttcaa
5521   actccttgaa agcaacacat cttctattaa agaaaaattc ctcttagtac tctggtaggg
5581   atacagtaaa tactctcttt tctatcaata aatgtcaatt gtctcactga tagattgata
5641   ggcacagatg tgagactttc tacctgtctc cgtcatatct ggtgcttaat aaatatctgt
5701   caaatttatt atacttagtt gagtcataaa gatcagttct gaatctggta ttcagtggga
5761   caaatcacac tgtctctgca tccattttct catctgcaaa atggagatta aaaatgtctt
5821   cccaatctac ctcagagagt tactatgagg cttaaatgag ataatagtta caaaagtgct
5881   ttgaaaagct ttgcagcttt tttcctctac tgcatgaaga ttagggatta ttatagctca
5941   catttccttt gacagtagtc acagggtaaa gtagggtttg gtgtttatca cacagagtgt
6001   gtccctttct agcctttatt agaatggttg gccattctca gggaaacctg agtacaacca
6061   gaaaggtagg aagagaataa acatctggct tccagttttc ctgagaaggt atcacagcta
6121   tggaaactac aaaggtggtg aaatttcttt tcttttcttc ttcttcttct ttttttttaa
6181   gacagtttcg ctctgttatc caggcgggag tgcagtggca cgaactcagc tcactgcaac
6241   ttccgcctcc caggtccaag agattcttgt gcctcagcct cccgagtagc tgggattaca
6301   ggtatgagcc atcacgccca gctaattttt gtatttttag tagagacagg gttttgccat
6361   gttggccagg ctggtcttaa actcttggcc tcaagtgatc ttcccatctt ggcctcccaa
6421   agttctggga ttacaggcat gagccaccat gcgtggcctt ctttcctttt ttaaattctt
6481   tttttctttt taaattttaa atagaagcag ggtctcatta tgttgctcag gctggtccgg
6541   aactcctggg ctcaagtgat cctcctgcct cagcctccca aagtgatagg attgcatgca
6601   tgagctacca cgcctggcca ggtggtgaga ttttgaaatg gaaattccca agtgaagtta
6661   gtctttattg ctcctaattt acatatcctt tctgcactct tgttccattc cgaagctttc
6721   tgttgtttta gttccctcct ggcaggttgg atgcaagacg tggtgtaaag aaagcttagt
6781   gaagaggtga gaacttcttc cttctggaga agatcctctt ctctgttcca tttttccaga
6841   ttccaaaagg aaaatattac tctggttatc actgaggttg acatcatttt ttatttttct
6901   tcttcttatg tatctctctt cactctctcc ccctttcctt tccttctttt tgtatttaca
6961   atttcatgat tttttcccct tctcctctct tcctgacctt ggtcctttag ttgaccataa
7021   taccaaagta tatttgttat cgtcagtggt atttcttgag atgttttttg tctctgtttt
7081   taataaaaat aaaactattt ggggtgtaag ttttatatat ccctttatta aagcaaatta
7141   taaaatgtat taattttttt attgatacat aataattgta catatttacg gggtatatgt
7201   gatattttgg tacatgtata caatgtgtaa tgatcaaacc agaataactg gcatatccat
7261   aatctcaaac atttattatt tctttgtgct cggaacattt caaatcttct aggtattttg
7321   aaatgtacaa taggctgggc atggtggctc atgcctgtaa tcctagcact ttaggacgct
7381   gaggcaggtg gatcacttga gccctaggag tgggctagcc tgggcaacat agcgagacct
7441   tgtctctata aaaaatacac aaattagctg ggcatggtgg tgcacgccta tagtcctagc
7501   tactcaggag gctgaggtag gagaattgct ggagcccagg aggtcgaggc tgcagtgagc
7561   cgtgattgca ccactgcact ccagcctggg tgacagattg agaccatgtc tcaagaaaaa
7621   agaaatacac aataaactgt taattatact caccttactt tgctatcaaa cactagattt
7681   tactccttct aactgtattt ttgtatccat tagctaacct cccttcgtcc cccagcccac
7741   ctttcccagg ttctgataac tattgctcta cctccatgag atcaactttt tcagctctcc
7801   catatgagtg agaacatgtg atatttgtct ttctgtgtct ggcttatttc acttaacaca
7861   atgaccttca ggtccatcca cgttgctgca aatgacagga tttcattctt ttttatggct
7921   gaatagtatt ccattgtgta tatataacac attttcttta tccatgcact attgagggac
7981   acttaggttg atccatatct tggctattgt gaatagtgct gcaataaaca tggaggtgca
8041   ggtatctctt tgattactga tttactttcc tttgaataaa tgcccagtag tgggattgct
8101   ggatcacata gtagttttgt ttttagtttt ttgagaaacg tccatactgt tttctataag
8161   ggcagtacta atcgtattct caacagtgta aaagactttc cttttctctt atatatggag
8221   tgagatgata tctcactgta gttttgattt gcattttcct gatgataaat gatgttgagc
8281   atgttttcat atacctgttg gccatctgta tgtattcttt tgagaaatgt ttatgcagat
8341   cctttgccca ctttttaatg ggattattat tatttttttg ctgttgagtt gagttccttc
8401   tatatgctgg atatcagtct cttgttggat gaatagtttg caaatatttt ctcccattct
8461   tcaggttatc tcttcatact gttaatgttt cctttggtgt gcagaagcct tttagtttaa
8521   tatatttcca tttgcttatt tttgtttttt tggcctgtgc tttcaaggtc ttagccataa
8581   aatccttgtc cagaccaatg tcctgaagca tttccccaat gttttcttcc agtagtttta
8641   cagttttagg tcttatgatt aagtctttaa tacatcttca gttgattttt gtataggtga
8701   gagagacata aaggtctagt tttattcttc tgcatatgga tatctggttt tcccagcacc
8761   atttattgga aagactgtcc tttcccaatg tatttccttg gtggtttgtt ggaagtcagt
8821   tggctgtaaa tgtgtgggtt tatttctggg ttctccagtc tgttctattg gtttatgtgt
8881   ctcttttcat gtcagtacca tgctgttttg gttactatag ctttgtagta tattttgaag
8941   tcaggtagtg tgatgcctcc agctttgttc tttttgctca ggattgcttt ggctattcag
9001   ggtcttttgt ggttttatac aatttttagg attgtttttt ctatttttgt gaacaatgtc
9061   attggtattt tgatagggat cacagtgaat ctgtagattt ctttgggtag tatggtcatt
9121   ttaataatat taattcttcc aatccatgag catgggatgc ctttccatgt ttttgtgtcc
9181   tcttcaattt tttaaatcaa tgttttgtag ttttctttgt agtaaaatat attttttatt
9241   agtgcttaac cctagactga tgttttcttt tgggttattg tttcccagtg aggcttcatg
9301   catatatttc tgcaggtctt cccaggaaaa atgacattta aaaagagaat ttttggaaaa
9361   gagatgcaga tatgtgggcc tgatgctgga acttccagtg caatggtggg acagactttt
9421   tttccagtgg cttcttttct ggtctctctt tctctctctc tctttgagac agagtcttgc
9481   tctgttgccc aggctggagt gcagtggtgt gatcttggct cactgcaacc tctgtctctt
9541   gggttcaagt gattctcctg cctcagcctc ccaagtagct gggactgcag gcactcacca
9601   ccatggccca gctagttttt gtatttttag tagagatggg atttcaccac gttggccagg
9661   ctggtctcga actecaggac tcaagtgatc tgcctgcctt ggcctcccaa agtgctggga
9721   ttacaggcat gacccaccgc gcccggcctg gactttcttt taaaagcggc tagagggcca
9781   ggcgtggtgg ctcaagcctg taatcccagc actttgggag gccgaggtgg gggggtgggg
9841   gtggggtgga tcacctgagg tcaggagttc gagaccagcc tgacaaacat ggtgaaaccc
9901   cgtctctact aaaaatacaa aaattagcca ggagtggtgg caggcgcctg taattccagc
9961   tactcgggag gctgaggcag gataatcgct cgaacccggg aggtggaggt tgcagtgagc
10021  caagactgtg ccattgaact acagcctggg caacaagagc gaaactcctt ctcaaaaaaa
10081  aaaaaaaaaa aaaaaagtgg ttagagtact agccaggggg aagcaagcac atttgaaaaa
10141  tatagtgtgt atgctttagg atagggagga atggagagag agaggaggac atggaccggg
10201  gtggaaaaat gtggggtttc gcattgattt ttggtgtgag cttgaacaag ttttgtacta
10261  aaaaaaatgc ctgttttact actaaaataa gtgcttcctt tggagagtga ggatcctctg
10321  ttactgaggt ttgtattttc aggccctagc atataaatct gctacatacg agatattcaa
10381  ctggttttgg aggaatgaag gtgaacatgg cagtttcctc atctgtaaaa gcagggtttg
10441  gacgaaatga tctgcaaaat gggtcttttt gtactcttac tactctagta tttacgagta
10501  accgatgtta ttccttataa agtctcaact cctggtKtga gccatgtctg acgagggggc
10561  ctaactccaa taccaccctg aacactctgg ggtcagtggg accctgtttg tacagacgtc
10621  tgcgtcttcc ggctctttag gacataagca gtactgctat ggaagaaagg aaacctaatt
10681  tcccatgcct tgtccctttc tggaaagggc atggcgtggt gtgggcacca cacctgcccc
10741  agccttctag caagaaaaca acacaacctt ccccgctccc cgaaaagagc ttctctccag
10801  ttgggtctag atgccccctt cccaaccagg gcggatggcc aaaggctccg ctcccttgca
10861  gggtaggctt ggaaaggcac ggggcccgcc ttcctgggca ccggagcctg tgacgggcgg
10921  agggcgtgcg gcgcgctggg ttagttacct ggcgctgggc ggggcaagcg ggaggcgggg
10981  gcggggccgg ggtgacatct caggctgtga ttgggccgcg ccgcgcctgt ctccatgtgc
11041  cgcgcagctg aggcacaaca ttcaagcccg ggggtggggc cggcgcgcgc cgggaggaag
11101  cggccgcgcg gcagctgcgg ggcgtggggg tggtggtggc ggcggcggtg gtggcggcgg
11161  cggcggcggc ggcagctgag gccgaggagg cggtggctgt ggcggacgca gcagcacccc
11221  agctagggac agggctccgc cgcgccccct tgctggcccc atggaggcgg cagcggcggc
11281  ggcggcggcg gcagcggcag cggcagcggc gggcgggggc tgtggctccg ggccgccgcc
11341  gctgctgctg agcgagggcg agcagcagtg ctactccgag ctcttcgcgc gctgtgccgg
11401  cgccgcgggc gggggccccg ggtctgggcc ccccgaggcc gccagagtcg cccccggcac
11461  ggccactgcg gccgccggcc ccgtggctga cctgtttcgg gcatcgcagc tgcccgccga
11521  gacgctgcac caggtgggtc cctccgcctc ctgtccctgc gggtctgtgg ggcagtgtgt
11581  gcgggggcgg aggttgcgag tggggcgaca gggctgcccc cagggacccg gaggcctcgg
11641  ccagttctga gagagaggac tctgcagccg gggatggcgg cgacgccctt gtccccgggg
11701  gacaccagcc tccttcgcag ctcagctcct cgcccagtgc tgggtgcgct ctccccatct
11761  tccttccctg agacagtctg acactctctc ccctcccccg gccatttctg gggttctgca
11821  gccgcccaga cccaaagttt gtcctgttct ggaagtggtg tttgttttgg ctgctgcctg
11881  gtttaacctc tgctcgctgc tcctgcccct ccctctcctg agtgggttct cagggtgcct
11941  tgctgggatt tcaacttgaa gggtgtgtgt gtccgtaggg ttcgaggccc agggctgaat
12001  gttgtcctct ctatgtagtt gtaatatata agtatctact atatgtaatt gcccataaca
12061  tatttctaaa tattaatatt aaatcgaaaa ccttaatgac aagttgcaga acagggacac
12121  gggactgcaa gaggacgttt gtcaagtcaa aaccaaattt cccatttgag attagaggtg
12181  gacttcagaa gtccaccatg ggaaacagct gtagtttccc atctatcatt acttggactt
12241  gaaatagaat tgaaaggtaa gggatgtcat agctaccacc ttttggctgt tctatacttg
12301  gaaaagtact aggggatgat acataccaga cgctgttttt gttttgtgct ttccttggag
12361  cttggagaaa gactacttga taagcctttg tctgtcattt catgtcacca gcacttcatg
12421  gtgataagac tgttaatatc aggttcaaaa cgtgaaatga agcttttcct aaaagcaata
12481  gtatgaatgt tattaacacc aatggaatat ttagagtggc gagtggtatt ttaaaatcta
12541  gtttcaaagg agaactgagg gttttatggt tcacttgcaa tgtcattgtg ttcatacgta
12601  tttttaaaaa aattgcttaa gactgcgttt tatactgctg gagtgttttt actgctatat
12661  gtttgtgagc ataactttag acactttgta atctttcacc cttttgaatt tgggatttct
12721  gaaactgtaa ctagtattca cagaacttag catggctgtt tatccctaaa gaagtccttg
12781  atatgtagac agttctgcca ttgctgatga gtagttgagc tggatcaggt aaagagaaag
12841  tcagtgtctt aaaacacaaa ccgtggctat tacatgaggc cctcagaata gtcccgagca
12901  taatacattt attcagtgct gtagctgctt cccagctgaa agaggaataa ttgactgagg
12961  ctatgcagca agtaagtgac agctgggtac ctattaaggc ttattttgtt gtcagtaatg
13021  catcggataa gaggaggtgg gcatagtaaa tctgaatatg ttggttgatg cctctttagg
13081  aattgggaag aaggatttcc tgatgttaga acccatgctt tcttgaggta catatagttt
13141  taaaaggacc caaggcacag tggctgtgcg tgaatgagat tatatttttg atgtccagtt
13201  gaaatctgct tgcaaaagac tgcttcagat actggcaaaa ggggacatcc ctgcgagatt
13261  gcttggagta aatctctcag agctcgaagc tcccttattc agcctagcaa agcaaaacac
13321  atcatccacc tttaatccaa caaaattacc ataactcaat attcttggta caggtgaaaa
13381  tgaacattga aggcatcctg gacatgtgat cctaagagag tcaaacaaag tcagcaacca
13441  gcagacacct aattttcacc catcactttg gtggtggtgg tggtggtggt ggtgNtggtg
13501  gtgtgtgtat gctccatcca ctttaatttg cattacccca tcagtgtatt agccattctt
13561  taaaacaaac gtagatgttt ttaccctttc tctgttaaac aggaacctgt aagttgagat
13621  ttaagtgccc caacaggtat aactgctcaa atcttggagg cactaaccag tcctgatatt
13681  ttctatggta acaaccaggt tttcctctta ataagcatac aattaagatt accataataa
13741  tgttccagga agagtgagaa tcttgcattc ttaccacaag taaatggtct ataaaaatac
13801  ttatttttta tttatttatt ttttgagatg gagtctcgtt ctgttgccca ggctggagtg
13861  Yggtggcgtg atcttggctc actgcaacct ctgcctcccg ggttcaagcg attcttccgc
13921  ctcagcctcc tgagtagctg ggactacagg cgcacgccac ctctcccggc taatttttgc
13981  atttttagta gagacggcgt tttgccatgt tggccaggct ggtctcgaac tcctgacttc
14041  aggtgatcca cccgcctcag cctcccaaag tgctgggatt acaggcgtga gccaccatgc
14101  ctggccttaa catatttttt aatagactat tttttttttt cagagcagtt ttaggttcac
14161  agcaaaattt agcagagtac ccatatatcc cctgccccga cacacccgta gctttcctta
14221  ctctcaacgt cccacatcag aataatagag tttttacaat tgatgaacct acattgacac
14281  ctcattattc cccaaagtSt atatattagg gctcactctt ggtgttgtac attctgtggg
14341  tttggacaaa tgtataatga cggttccacc attgtagtat catacagaat agtttcactg
14401  ctctaaaaat ctgtgctcta ttgattcatc cctccctctc cactaacatg tggcaatcac
14461  tgattttttt ttttttttta ctgtccccat agttttgcct tttttagaat gtcatatagt
14521  tggagtcata cagtatatag gcttttcact ttggcttctt tcatgtagta ctatgcactt
14581  aaaattcctt catgtctttt tatggtttgg tggctcattt ctttatagtg ctgaataata
14641  ttccattgtc tgcatgtact acaatttatt tattcaccta ctgaaggata tcttggttgc
14701  ttccaagttt gggcaattat ggataaagct gttataaaca tctgtatgca gccttttttg
14761  ttacatgcag gagataagct tttgactcat ttgggtaaat agcaaggggc atgattgcta
14821  gattgtatgg tgagagtata tttagtttta taagaaactg ccaaactgct ttccaaagtg
14881  attgtaccat tttgcgttcc catcagcaat gcattggttt ctttacagag tatttatttt
14941  cctttgctga cttattttaa cagcaggatt ctagcactag gtggaaaacg tatatgagtt
15001  tctgatgtgt gtcaggtact gtcctaggtg ctgaggttat aatagtgaat ccaacacaat
15061  ctctgtcttc atggagctta tgttctcatg tgaatgtttt tacacttcag agtttttatt
15121  tggttgagaa aagacttgaa atataacatc caaaaataaa atgtcagcct ggtgctgtgg
15181  cgcacgcctg tagtcccagt gctttgggag accaaggatg ggaggattgc ttgaggccag
15241  gactttgaga tcagcctggg taacatagtg agaccctgtc tctacacaaa ataaaatagc
15301  cgggcatggt ggcatgcgct tgtagtccta gctactctgg aggctgaggc aggagaattg
15361  cttgagccca ggagttcaag gttatagtga actatgatcg caccattgct ctccagcgta
15421  ggcaacagag caaaaccctg tatcaaaata aagtaaaata agcctgtcaa acccaaacca
15481  aatacatgtc aaacccagac ctgattctta ccacacacta tgccttctag taaaattctg
15541  gcctttgaat accaacaaaa tacttcataa cctgggaaac caactactct aacgtttgtt
15601  gctctgtctt gaaatactaa acaaaaccat ttacctgttc gtagacatat tttctttttc
15661  tagtttaaaa gtatcccatt ctgccatttt ccacctagtg ctagaatcct gctcttaaaa
15721  taagtcagca cagggaaata aatactctat aaagagacca aaagaccttt caaaataggc
15781  tatggccagg cccagtggct cacgcctata aatcccagca ctttgggagt ctgaggtcgg
15841  aggattactt gagcccagga gttctagact agcctgggca agatggcaaa accccatcta
15901  cacacacaca cacacacaca cacacacaca cacacacaca cacacacaca cacacacacc
15961  cccgctacct acctctctct ggggcatgcc tgtagtccca gctattctgg aggctgaggt
16021  gggaggatcc cttgagccca ggagtttgag gctgcaatga gccattatga caccactgca
16081  ctccagcctg ggtgaaagag ccagaccctg tctcataaaa taaataagta aataaataaa
16141  atatctacct taaagcagca agttttgtat ttgatgtaat gaattaacag accgctttat
16201  aatatctatc ttttaggata gtgtcagtct cttggaatgc tgtgcatgag tcatcattaa
16261  aattggtttt cattaaaaaa atttttttaa catatacaca tcttattgga gttttctttt
16321  aaaattcaaa aatgggaaca ttattttttc aaagccaagt aacagaagag tatataaaaa
16381  agtcaatttt gtgcatatct ttttacattt tctatgctca tgtaaaacat acatgactta
16441  tgtaattata cacatatgct ccagatctca tctgtattaa ttttttaaat tatactttag
16501  ttctgggata cacttggaga acgtgcagtt ttgttacata ggtatatata tgtgccatgg
16561  tgatttgctg cacccatcaa cccatcatct acattaggta tttctcctaa tgctatctct
16621  cccctagccc tgcacccctg aataggcccc ggtgtgtgat gtttccctcc ctgtgtccat
16681  gttttctcat tgttcagctc ccacttatga gtgagaacat gcggtgtttg gttttctgtt
16741  cctgtgttag tttgctgaga atgatggttt ccggcttcat ccatgttggt tttcattttt
16801  gtgatagtta attcttggac attaagggga ataattataa aacactgttg cttccatatc
16861  aagggaaatc actgaatgat taaaaaaaac ccaataagtg ttgtctgatt gtttaaacag
16921  ctttcattga ggtaaataag taaaacaaag ctgtgagaag tagggaatat ttaaacaatt
16981  tgtgcgcatg ccctcacctt tggggagaag tcttttctga aggctctctt ctgatttttt
17041  gaagcaactg tttaatcatt aaagaaaatt ataggtaaaa gacaaattct tgtgaacttt
17101  cgctcattgc tagattatta ggcagaacta ttttttaaaa atttaaatga aacaacttta
17161  tatttttaca tctttagatc atatcatttt gtaactatac tttagggaaa tagaggccag
17221  catattaaaa cagtaactag gggctgggca gggtggctca ttgcctgtaa tcctagcact
17281  ttgggaggcc gaggcgggca gatcagctga ggtcaggagt ttgaaaccag cctggccaac
17341  atagcgaaac cccatctcta ctaaaaatac aaaaattagc aggagaattg cttgaaccgg
17401  agaggcgaag gttgcagtga gctgagatca ggccattgca ctccagcctg ggagacaaga
17461  gtgaaactct gtctcaaaaa caaacaaacc aaaaaacaaa cacacacaca cacacacaca
17521  cacacacaca cacacacaca cacaaacaca caaaccagta actaggacta actatatgct
17581  gttttagatt gacagtattc tttttttcta aaagagaatg aatgccagca gatgtaggaa
17641  gtaccagagc taaaccattg cctggttaaa aggagtacct ctgcataata gttacttgtt
17701  gactcttttg taataaaata tttcaggcat gtaaaactag acagttaccc aagaaataac
17761  tgtgtatcca ccactccgta taagtaaaac agcccagcta gagtgaaagc ctgctatgtc
17821  cccttctctg gtcccattcc cctccctccc taccctggag ttaccagagt cctgaatttg
17881  gtgtgcatga tttgaagatt tctttctact tttattgtat gtatatgtgg atatatatat
17941  ttgtgtatat ataaatcact aaaaaagata ttattttgga tgtcttttca acttaaggaa
18001  tatcgtattc tgtgtaacct tctgcaactt gcttttcctc tcattgtttt gtttttggaa
18061  ttcatcttgt tgacacatgt aatttcagtt catttatgtt tccttttaaa aaatctttac
18121  tacttacgtt tacaatgact cattgttaca gtgcggtaga gacccttatg ccaaaaggaa
18181  gtaggtggca tttttcctta tttatataga atgtcacatg actgggggac tgttcgaaac
18241  gtgtatgaaa attaagaaca ccttcataga tagcagaatg cacacttata ttcttgagcg
18301  tgctagggga tgtttgagct aattaattga ctttcatggg ctttcttttt ttctcatctt
18361  ttattttttt gagacagggt cttgctgtgt cacccagact ggaatgcagc aatctgatca
18421  tgactcactg taccctcaac ctcctgggct caagcaatct tcctgcctca ggctcccgag
18481  tagctgggaa tacaggtgtg cagcaccaag cctggctaat tttcttt-tta aaaatttgtt
18541  gtggagatgg tgtctcatta tgttgcccag cctggtctca aactcttggg ctcaagtgat
18601  ctcccgcctc agcctcccaa agtgttggga ttacaggtgt gagccaccac accctgccat
18661  ttttcatctt tttaaaaatg gaacatctca aataagcaag tagatagaat aatgcattaa
18721  accctgctgc acttgccact caggcccaac aactgtcaat gcaaggttaa ttcaattcca
18781  tctacatttc tatctttgtt ccctctcacc tttgttatcc tgaagcaagt cgcaaacatc
18841  atatggttca tagggcttat ctttaaggaa ggaaccaggg tgggcagaag gaaatggaaa
18901  catgcagggg tttaggttgg ccagaaaagg tacctgtggc ctatggtcaa atggcaagac
18961  tgatgatggt tcaatactgt caagcctttg gctgtcatgg agatagacgt gcttgagaac
19021  tgatttagaa tagttgggaa acctgtaggg agattgaaaa agtaaccaac tgaagaccag
19081  gaatacaaga tggatttgaa tattgttcta gcttcacact cctaagtagg ggctgtccta
19141  ttttaagggt gtagacaatt ggttttgagg aaatcttggg ttgtttttgc taattattta
19201  taactttttt tttttttttt tttttttgag acagagtctt gctctgtcgc ccgggctgaa
19261  gtgcagtggc gcaaggtcgg ctcactgcaa cctccgcctc ccaggttcaa gcagttctcc
19321  ctgcctcagc cttctgagta gctgggacta caggcgccca ccaccatgcc tggctaattt
19381  ttatattttt tagtagagat ggggtttcgc catgttgact aggctggtct tgaactcctg
19441  acctcaggtg atctgcccac cctggcctcc caaagtgctg ggattacagg tgtgagccac
19501  cgcgcctggc ctatttataa ctttaaaaag agggtttggt tcctttccag ggtttttcaa
19561  actttctgtt tgtttcgtat aggcaagttt ctcatgtttt gtattgatgg cattctatta
19621  ttcataccta tctgttggtg ggcaactaat caacctgggt tgcgcaggac tgaaggattt
19681  cctgggggca tggaacttca gtcttcagac agtcctaggc aaactgggat ggtcaccccc
19741  tctcttggtt gctgcattag ttatctattg ctctataatg aattaccaca aacttagcag
19801  cttaaagcag cacacagtta ttatctccca gtttctgtgg gttcgggagt ctggacatgg
19861  ctcagttggg tcctcagctc agagtttcat aaagccacaa tcaaggtgtc tggagcttgg
19921  agtcctctgt ggaggtccaa cacttggttg cagaattcag ttccttgtga ttttagaact
19981  gaggctctca acttcgaggc ttcctgcagt tccctccaca tggccttctc cataggcaat
20041  tcacaacatg gctcttggct tcttcaaggc cagcaggaga gtgtctctct ccagttagct
20101  cagacacctt tgccatagtc cattagttag aagcaagtca caggttttgt ctgctctcaa
20161  ggggagggga ttatacaaaa caacagagac caggaggtga gaattttgcg ggggacacct
20221  taggatcttt ccaccacact tgctttccag gatttgtctg aagtagaaaa ttattctgtt
20281  gagccttttt gtggccagaa tatacatatg ttttgctcag ccactaattt agaattcctt
20341  tatcttttta agaaacattt tcatgcgtaa ttcatcctaa gtagaactgg caaatatgta
20401  acttcttagg tattttcaat tttagtcttt aggcaattgt ttttcctctt aactagtagg
20461  aggcaggaaa aaaaagtgga aaagcagatg caaatgccct gcctggctac tcctgcacgc
20521  agtgctctaa agcaggcctt ctcagcctgg gttagttcag gggtctgtga atttagatgt
20581  ggaaaagaac tacatctttt tttttttttt tactaactgc ccttccccca actgaaattg
20641  agcacttcct tctattatgc atgtaagcaa aaaaccacag cagttttttt tttttttttt
20701  tttttttttt ttttttttga gacagggtct tgctctgtca cccaggctgg agtgcaatct
20761  cacaattttg gttcactgca acctgtgcct cctgggccca aatgatcctt ccatctcagc
20821  ctcccaagta gctgggacta cacgtgcatg ccaccacacc cagctaattt ttgtattttt
20881  tgtagaaacg ggattttgcc atgttgccta ggcaacaggg ttcactgctt tcggtcaaat
20941  gacagcaatg ctgctggcaa gtccatggtc aggagtgaga ttccctcagg ctgctgtggt
21001  ccctcctcct ccagtctgtc ctgcaggaag ctcagagtga atggatgctc agctgtttcc
21061  tctgagacct caccagggac agttcctgca gtcccggctc tgagctctgc tcctgaccgt
21121  tttatctggc cctctcagct gtgcttcact gcaaaggagg aaggacaagg ccctctggag
21181  ccagtgccag ctgcttgtgg ggcctgtttt atttactact gctatctcta cttcagagac
21241  ttgggctagg acatagactt gaagaaaaaa gccattttaa cagacttgag aaactcagcc
21301  atcctcataa taccattcag aaccaggaga ggccattatt aacactaggc tagtaggaaa
21361  tgttcacttt gactgaattc atttgtaaca ctttgccact ggtttacaag aaaaatactt
21421  tggttcagtc tcctggaggt aggtaattaa atgtttcacc tgtgctaatt ttccaaataa
21481  ttaaagtgaa tcccataaat gccagcaatt aagaattgtt gtttttggcc aagtgtggtg
21541  gctcatgcct gtaattacag cactttggga ggttgaggcg ggcggatcac ttgaggccat
21601  gagtttgagg ccaacctggg taaaataggg agacgctgtc tctacaaaaa atacaaaaat
21661  cagctgggct tggtggaatg tgcctgtagt cctggctact tggtaggctg aggcaggaga
21721  attgcttgaa tccgggaggt agaggtttca gtgagccaag attgtgccac tgtactccag
21781  cctaggcgac agaggcgaga ttctgtctca aaaaaaaaaa aaagttgttt cttaagtgca
21841  gaccttctga gatgtgtagt gcttgcccca tgccttcaaa agaacatatt taatacaata
21901  atctctttgt ctctccttta cttcaaagtc agccttgtga aaaacagatg atgatatacc
21961  aacagttttt tgctcttgga ggtgtttggt gtgctctgct ttttgagttt tgttttttgg
22021  acttctttaa aattatttta aaatgtttta actcctctcc tttgcatact ctctggtacc
22081  cttatagtcc caatactgag taaagcatgt aaaatttagc atgcagatgt tttagcctct
22141  tttatttttt gttcgagatc cagatttttt agtctcagca tgactgacac tttggggctg
22201  tatcattctt tgttgtggag gactgtcctg tgcattgtag gttgtcaagt aacatccctg
22261  gtctctaccc acaagatacc agtagctatt cttctcctga ttgtgacaac aaaaaatgtt
22321  tccagacatt gtcagatgtc tcctcggggc aaaatttagt tctacatata tgatgataaa
22381  aaccatggta gcagccaaca tttgttcact atcatcccca ttttgaagaa agcaaaaacg
22441  gaggcactga gggtgaggtt cacttacttg cccaaggtca catagataaa agtcacttct
22501  tgaaatactt ttcataatat atatgggttg aatctcagtc ttaattgagg aggcagacta
22561  aaaaagaatg taaaaacggg gagtttcctg atgatgtctc aattgagagg ctattgcttt
22621  catagtgatt ctgtgtaaat gctggaattc ttgcttaaac ggggtgattc catgggcatg
22681  tgtctgagta aaggacttgg atcatttcta agaagcttct gtggcatggt gaagcagaac
22741  ataagacagt ctaggatcaa ggataactga tcaaactttg aaaccaagga agccatagga
22801  aattggggta aggctatgta tcacttaggg tcccacagga aatggcatgc tcaaagggtt
22861  ttagtgaaaa caggaatgtt gaggcacgaa gggactagca gcaggaagct attgccattc
22921  ctagacctgg tggggcaaag ggaggggagg gaatgtcgtt gctggagctg tgaaaggtac
22981  tccctctaca ggaacaatag tcatgaaaga atacagcctt tgctagaact atggccagag
23041  aggggccagt gggatgaggg gatgggagag aagtaaccaa tttctgtttc ctgccctctc
23101  atttgctgca gtgccttttg ttgttctaac ccaactagaa gccacaggta acagagcctg
23161  ggtgttgaag cttattgagg ttagcctctt gcgctgagtg gatggaaagg gctgagagtg
23221  gttcaagggg gcaaatagag caacagccag cacaggctat gagcaggagt gggaaacact
23281  accctggatc ctaggaagga tggggcatgg ccagtgatag gagcaatgaa agtctttttg
23341  tgtgaaaaag agcctgggga tacagacctc catgaaggag aagagagggt tggataggag
23401  tgactggttc atctgaggtt cttcctattt ctccaaggaa gccttgagga atgtggggtt
23461  gtctgtttgc atttggatat ggaagtatgt gtgtgtgtat acttttattt attttgagac
23521  agggtcttgt tctgtcaccc aggctggagc acagtggcac catcacagct cactgcagcc
23581  tctacttcct gggcttaagt ggtcctccca cccaggcccc cccaggtagc tgggaccaca
23641  ggcatgtacc actatgctcg gctgattttt aatattttgt agagacaggg tctcactata
23701  ttcccctggt tggcctcact cctgggctca agtgatcctc ccaccttggc ctccagaagt
23761  gctaggaata caggtgtaag ccactacacc cagtctgttt gtatactttt tggtcagagt
23821  gaggctttcc gtgagttgga gtgtttgtcc ttattcatga cactgggaaa catacaacag
23881  tggagtgacc ctcttgcaga ttctgctagg agtagctaca tatggtggga aaggttgcta
23941  tgggaatgga gataaattca aRgcagtaga gagtgcttta taatgtttgg gggtatggcc
24001  aagcattagt tttgcttttt ccttcccagt aggatacgat ttctgtagca attcttcctt
24061  acccaaaaat agctatatgt gctcccaaaa agaaaaagcc caggaccaga tgacttcatg
24121  gctgaattct accaaacatt caaagaagag ttaatactaa tccttcttaa actcttccaa
24181  aaaacagaag tagagagagt acttccaaac tcattttttg aggccagcat caccctgatt
24241  tcaaagccag acaaaagata ccaagatacc ataagaggag aaaaccacag gttagtatct
24301  ctgttgaaca tatatgcaaa aatcctaaat aaaatactag cagaccaaat ttaacaacac
24361  ctcaaaaaga tgatacacca tgaccaaagt ggcacttatc cctgagatgc aagattggtt
24421  taacgtatat aaaacaatca gtgtaatatg ccacattacc aaaataagag gtaaaaaaca
24481  agccaggtgt ggtggctcac acctataatc ccaacacttt gggaagctga ggtgggagga
24541  ttgcttgagg ccaggagttc aagaccagcc tgggcaacat agtgagacac tgtctctaca
24601  aaaaattaaa aaaaaatgag ctgggcatag tggcatgtac ctctagtccc tgctacttgg
24661  gaggctgagg cagcaggatc gctggagccg aggattttga ggctgcagtg agcactgatt
24721  gtgccaccgc actccagttg ggcagtacag caagaccctg tcttcaaaga aaaaaaaaga
24781  gagaaaaacc catgatcatt tcaatacatg tagaaatagc atttgacaaa gttcaacagc
24841  ctttcgtgat aaacattttc aacaaaataa gtttaaaagg gaatttcctc aacacattaa
24901  agaccattta tgtagagtcc acagctaata tcataatcag tgggagaaaa ctgaaagctt
24961  tttttctaag atctggtaca aagcaaggat gcccactctt gccactttta ttgaacacag
25021  cactggaagt actaacatga gctatcagac aataaaaaga gataaaaggc atctaaattg
25081  ggaaagaaga agtaaaatta tccctgtttg taaatgtcat gatcctatat gtagaaaacc
25141  ctggactcca caaaagccct cttaagacta ataaatgagt tcagtaaagt tgcatgatac
25201  aaaatcagcg tacaaMaatc agttggaaat caagaaaact gtcccattta tgataacata
25261  aaaataataa aatattcagg aatacattta atgaaggaag tgaaagatct gtacattcaa
25321  cattataaaa tattgatgaa agaaattgaa gacacaaata aatggaaaga tatgccatgt
25381  ttatgcattg gaaaaattaa tagtgttaaa ttgtccacac tacccaaaac aatatacagg
25441  ttcaatgcaa tccctatcaa aataccaatg gcatttttca cagaaataga aaaaacaatt
25501  ctaaaattca tatggtgtga caaaagacct agaatagccg aaacagtctt gagaaacaaa
25561  aacaaggttg gaggcatcac acttccttag attataatac agtataaagc agtagaaatt
25621  atgatagtat atcctggcat aaaaacagac atatagatca atagaataga acagagatcc
25681  gagaaatata cagtatatat acagaaatcc aagtatatac agtcaactaa tttttgacaa
25741  ggccaccaag gagacacagt ggggaaagga tagtctcttc aataaatgat attgggaaaa
25801  ctggatattc acaggcaaaa gaatgaagct ggatgcttat atacaaaaat caactcaaaa
25861  tgtgtcttta aaatatacaa caaaacctga aaatggaaaa gaagacctaa atgttaataa
25921  ctcaaaccat tgaactccta gaagaaaaca taggggaaaa gctccttgat atcggccttg
25981  gcaatgattt tttagacatc acaccaaaag cacaggcaac aaaagcaaaa agaaacaggt
26041  ggtactacat cagactaaaa agcttctgca tgacaaaggg aacaatccgc aaataaaagg
26101  gcagcctatg aattggaaga aaatatttgc gacccatata tatgataagg agttaatatc
26161  aaaaatatat aaggaactcc cagaactcaa tggtaagaaa atgaataacc cgattaaaaa
26221  ataggcaaag gacttgatta ttcattttcc caaagaagcc atacaaatgg ccagcaggtt
26281  gtgaaaaggt actcagtatc actaatcata agggaaatgg aaatcaaaac cactatgaga
26341  tatcagctca caccttttag aatggctatt agaaagacaa cagataacaa acgttagggt
26401  gtggagaaaa gagaaccctt ttatactttt gatgggaatg tagattggta cagccattat
26461  ggaaaatggt atagaagtgc ctcaaaaaat taaaagtaga actaccatat gatccagcaa
26521  ttcctctgct ggatatgtac ctaaaggaaa tgaagtcagt gtgtcaaaga ggtatctaca
26581  ctcctgtgtt cattgcagca ttattcgcaa tagccaagat atggaaacaa tttaagtgac
26641  tgttgatgga tgagtggcta aaaatatcgt gggatacaca cacacacaca cacacacaca
26701  cacacacaca cacacacaca cacagatgac agaatattat tcagccttaa aaaaggagat
26761  catgctattt gtgacaacat ggatgaactt atgctaagta aaataagtga gacacagaag
26821  gaaaaatact tcatgatctt atttatctgg aacctgaaaa aaagagtcaa atatatagaa
26881  acagaataga accacggtta ccaagggtgg gaatggggag gaaataaggc aatgtaggtc
26941  aaagtgtaca aacttgcagt gatgtaggct caataagtct agagatgtac agcaggagga
27001  ctatagttaa caatattgta ttgtatatgg aaaatgtgct aagagtagat tttaggtgct
27061  cttacctctt ctccccacaa aggtaactat ggaaggtgat gagtatgtca gattgcttac
27121  tggtagtaat catttcacta tggatatgta tatcaaaaca tcatgtcata catgttaaag
27181  ttatgccata aaaatagcta tatgtgggcc aggccaggca tggtggctta tgcctgtaat
27241  accagcattt tgggaggctg aggcaggagg attgcttgag gccaggagtt taagaccagc
27301  ctgggcaacg tagtgagaaa cctgtctctc caaaaatgtt tttaaaagtt atctgcgtgt
27361  ggtagtgcat gcctgtgatc ccagctactt gggaggctga ggcaagagga ttgcttgagc
27421  ccgaaaggta gaggctgcag tgacctgcga ttgcaccact gcactccagc ctgcgtgaca
27481  gagtgagacc ctgtctctta aaaaaaaaaa agattaaaaa atagttgtat gtgtatatgt
27541  atacgttcag gatttgttct atttgttttc tttttctttt ttttcatagg cagtggtcaa
27601  tggcctaagg atttctttat acattgctca tatccactaa ggctctattg agcaaaccac
27661  gccttaaaaa tcttacaatc ctcttcatat attttaaagg caaatgcaaa gaaatagctt
27721  tgttctgttt tgcattcttc atgggttaac atatcttctg gaaaacttgt tgctatggca
27781  atgggatatt atctatcttg gtaatgtact acataaaaat agccctttgt gtttgagaat
27841  gatgttagtg acaggtggtt gggtgaatgt atagcaggct gctttgtcaa gaatagtttc
27901  ccaacattcc attgtttaaa gttgtgaaat caaaatgagt ataatttttt tctctctcaa
27961  aatgtaattt tatctggaaa aggcaggcag tggtgctctg tttaattatg aattacaagc
28021  cttcctttgc aggtcaggtc aacatgatga ttgaagccac ctctcactgt aataagtaaa
28081  cgacttctct attctttctg tcagggtgtg cagcacaagg ttgcgctggg ggggccagta
28141  gggataattt tcccattctt gaacacatcg ttcttcctaa gcacctcgta cttataaacc
28201  aagaagtagg aagtggtcag gtggaagaga tgagctctga gctgttaatc aaatccgaat
28261  ttcttgtagg ttcttaggtg aaacagttcc ttgggaaagg tcagatttcc atgttgcttt
28321  tagtattgaa ctcacacata tagccaagga tagaatctga cccaaatctt aatttttcct
28381  ttgaaaaatc ctttgggcaa ttttttttta atttaattta attttattat tattattatt
28441  attttttatt gatcattctt gggtgtttct cgcagagggg gatttggcag ggtcacagga
28501  cagtagtgga gggaaggtca gcagataaac aagtgaacaa aggtctctgg ttttcctagg
28561  cagaggaccc tgccgccttc cgcagtgttt gtgtccctgg gtacttgaga ttagggagtg
28621  gtgctgactc ttaaggagca tgctgccttc aagcatctgt ttaacaaagc acatcttgca
28681  ccgcccttaa tccattcaac cctgagtgga tacagcacat gtttcagaga gcaccgggtt
28741  gggggtaagg tcaccgatca acaggatccc aaggcagaag aatttttctt agtacagaac
28801  aaaatgaaaa gtctcccatg tctacctctt tccacacagt cacggcaacc atccgatttc
28861  tcaatctttt ccccaccttt cccccctttc tattctacaa aaccgccatt gtcatcatgg
28921  cccgttctca atgagctgtt gggtacacct cccagacggg gtggtggccg ggcagagggg
28981  ctcctcactt cccagtaggt gccgccgggc agaggcgccc ctcacctccc ggacggggcg
29041  gctggccgga cggggggctg acccccccca cctccctcct ggacggggcg gctggccggg
29101  cagaggggct cctcacttcc cagtaggggc ggccgggcag aggcgcccct cacctcccgg
29161  acggggcggc tggccgggcg gggggctgac ccccccacct ccctcccgga cggggcggct
29221  ggccgggcag agtggctcct cacttcccag taggggcagc cgggcagagg cgcccctcac
29281  ttcccggacg gggcggctgg ccaggtgggg ggctgacccc gccacctccc tcccggacgg
29341  ggcggctggc cgggcagagt ggctcctcac ttcccagtag gggcgcccgg gcagaggcgc
29401  ccctcacctc ccggacgggg cggctggccg ggcggggggc tgaccccccc acctccctcc
29461  cagatggggc agctggccgg gcggggggct gaccccccca cctccctccc ggacggggcg
29521  gctggccggg tggggggctg acccccccac ctccctcccg gacagggcgg ctggcagggc
29581  agagtggctc ctcacttccc agtaggggcg gctgggcaga ggcgcccctc acttcccgga
29641  cggggcggct ggccgggcgg ggggctgatc cccccacctc cctcccagac ggggcggctg
29701  gccgggcggg gggctgaccc ccccacctcc ctcccggacg gggcggctgg ccgggcgggg
29761  ggctgacccc cccacctccc tcccggacga ggtggctgcc gggcggagac gctcctcact
29821  tcccagacgg ggtggctgct gggcggaggg gctcctcact tctcagacgg ggcagctgcc
29881  gggcggaggg gctcctcact tctcagacgg ggcggttgcc aggcagaggg tctcctcact
29941  tctcagacgg ggcgtccggg cagagacgct cctcacatcc cagacggggt ggcagggcag
30001  aggtgctccc cacatctcag acgatgggcg gccgggcaga gacgctcctc acttcccaga
30061  tgtgatggcg gccgggaaga ggcgctcctc acttcctaga tgggatggcg gctgggcaga
30121  ggctgcaatc tctgcacttt gggaggccaa ggcaggctgc tgggaggtgg aggttgtagt
30181  gagctgagat cacgccactg cactccagcc tgggcaccat tgagcactga gtgaacgaga
30241  ctccgtctgc aatcccggca cctcgggagg ccgaggctgg cgggtcactc gcggttagga
30301  gctggagacc aacccggcca acacagcgaa tccccatctc caccaaaaaa atacgaaaac
30361  cagtcaggcg tggcggcgcg cgcctgcaat tgcaggcact cggcaagctg aggcaggaga
30421  atcaggcagg gaggttgcag tgagccgaga tggcagcagt actgtccagc ttcggctcgg
30481  catcagaggg agactgtgga aagagaggga gagggagacc gtggggagag ggagagggct
30541  gggcaatttc ttagagcagt aactctcaaa cattttgtcg tcatcatctc acttttcttc
30601  tacttatcaa aatgagtatt gatttaattg taatgagtaa ataacagctc cctgctactg
30661  aaatgaaatt tactctagct ttgagaattt gagagaccct cttaagaaaa taccacagct
30721  ggaaatttga gacctaaaag taatacaatt tgagtatctc atatctgaaa tgcttgggac
30781  cagaagtgtt ttggattttg gattttttca gactttggaa tatttgcgtt tacataatga
30841  gatctcttgg ggatgggacc caagtctaaa cacgaaattc attaatgttt tatatacgcc
30901  ttatacacat agcctaaagg taattttata caatatttta aataagcttg tgcatgaaac
30961  aaaattttga ctgtgttttg actgtgacct gtcacataag gtcaggtgtg gattttttca
31021  tttgtgactt catgtcaaca ctcagaaact ttcacatttt ggagcatttt ggatttcaga
31081  ttagggatgc ttaatctgca gctctaattc tgatatgcac ggtactactg cagagatgga
31141  accattgcct ttgtcttttc tgttggagtc agtatagata tcttgctact aataatatca
31201  gaagagagtg ttgagtggtt tgctgggtgc ccaatactac ttttagaaca ttttatgtat
31261  taactaattt attcctgtaa acattcttga cagtttttgt gactatttcc caaatgaggc
31321  gtacttgtta gcatgtcttt ctgtttgtgg tgagtaagca ttcttgtgta ttggaagact
31381  tgcttactag catgtcacag tgttcttcat attgaaagca ttcttctatc aggagttgac
31441  gtaattcagc ctgtgggcca aatccatcct gccacccatt ttttgtgtat tttataagct
31501  aagaatggtt tctgcatttt taaatggttg ggaaaacata aaaagaataa tttgtgacat
31561  gtgaaaatta catgaaattt aaatttcagt ttccataaac agttttattg gaacacagct
31621  ttactcattt gtttacatat tgctaaggct gcttttgaac tagagtggca gagttgagta
31681  gttgtaatag agaccatata gctcccagac cctaagaaaa agtttgccaa tcccttctct
31741  atattcttct gtatctagaa tggcagatgg tcctcaataa taacagcaga ttggtcaggt
31801  gtcatagttt atgcctgtaa tcccagcatt ttgagaggcc aaggtgggag gatcacttga
31861  gctggagttc aagaccagcc tgggcaacac agtgagacct agctctgcaa aaattagcca
31921  ggtgtcatgg tgcacgctgg tggtcccagc tacttgggag gctgaagtgg gaggattgct
31981  tgagcctggg aggtcaaggc tggagggaga cgtgatcaca ccattgtgct ccagcctggg
32041  tgacagagcg agaccctgtc tcaaaaatat ataaacagat tggatttatg tacaggttca
32101  tatatatatt aattttcttt tggtatgcaa tatatttttc tttcttccac taaacgtttc
32161  tcttgtcata agcttgatgt catgtactat ggcatatctc aaatatacgt gatttcagct
32221  ctttgcatac ccatattggt tttctttttt ttttttttaa ttgatcattc ttaggtgttt
32281  ctcgcagagg gggatttggc agggtcacag gacaatagtg gagggaaggt cagcagataa
32341  acaagtgaac aaaggtctct ggttttccta ggcagaggac tctgcggcct tccgcagtgt
32401  ttgtgtccct gggtacttga gattagggag cggtgatgac tcttaaggag catgctgcct
32461  tcaagcatct gtttaacaaa gcacatcttg caccgccctt aatccattca accctgagtg
32521  gacacageac atgtttcaga gagcaccggg ttgggggtaa ggtcacagat caacaggatc
32581  ccaaggcaga agaatttttc ttagtacaga acaaaatgaa aagtctccca tgtctacctc
32641  tttctacaca gacacggcaa ccatccgatt tctcaatctt ttccccacct ttcccccctt
32701  tctattccac aaaaccgcca ttgtcatcat ggcccgttct cagtgagctg ttgggtacac
32761  ctcccagacg gggtggtggc cgggcagagg ggctcctcac ttcccagtag gggcggccgg
32821  gcagaggcgc ccctcacctc ccggacgggg cggctggccg ggcggggggc tgacaccccc
32881  acctccctcc cggacggggc ggctggccgg gcggggggct gaccccccca cctccctccg
32941  ggacggggtg gctggctggg cagaggggct cctcacttcc cagtaggggc ggccaggcag
33001  aggcgcccct cacctcctgg atggggcggc tggccgggcg gggggctgac ccccccacct
33061  ccctcccaga cggggcggct ggccgggcgg ggggctgacc ccccccacct ccctcccgga
33121  cggggcggcc ggccgggcag aggggctcct cacttcccag taggggcggc cgggcagagg
33181  cgcccctcac ctcccggatg gggtggctgg ccgggcgggg ggctgacccc cccacctccc
33241  tcccggacgg ggtggctgct gggcggagac gttcctcact tcccagacgg gatggctgcc
33301  gggYggaggg gctcctcact tctcagacgg ggcggctgcc gggcggaggg gcccctcact
33361  tctcagacgg ggcggctgct gggctgaggg gctcctcact tttcagacgg ggcggttgcc
33421  aggcagaggg tctcctcact tctcagacgg ggcggctggg cagagacgct cctcacatcc
33481  cggatggggc ggcagggcag aggcactccc cacatctcag acgatgggcg gccgggcaga
33541  gacgctcctc acttcctaga tgggatggcg gccgggaaga ggcgctcctc acttcctaga
33601  tgggatggcg gccaggcaga gacgctcctc actttccaga ctgggcagcc aggcagaggg
33661  gctcctcaca tcccagacga tgggtggcca ggcagagaca ctcctcactt tccagacggg
33721  gtggcggccg ggcagaggct gcaatctcgg cactttggga ggccaaggca ggctgctggg
33781  aggtggaggt tgtagcgagc cgagatcacg ccactgcact ccagcctggg caccattgag
33841  cactgagtga acgagactcc gtctgcaatc ccggcacctc gggaggccga ggctggcgga
33901  tcactcccgg ttaggagctg gagaccagcc cggccaacac agcgaaaccc cgtctccacc
33961  aaaaaaatac gaaaaccagt caggcgtggc ggcgcgcgcc tgcaattgca ggcactcggc
34021  aggctgaggc aggagaatca ggcagggagg ttgcagtgag ccaagatggc agcagtacag
34081  tccagactcc cacggcatca gagggagacc gtggaaagag agggagaggg agaccgtggg
34141  gagagggaga ccgagaggga gagggagaga gggagaggga gagagggaga gggagagagg
34201  gagagggaga gatttggttt tcataataat cataaccctt tccaaatgag ggagagtaat
34261  gaattttatc attttattag ttagtgtgct tcctttgcta gatcaggaat tatatctcct
34321  agtaattata accctctatt tattattttt aactatattg ctttctactt ttgggctttc
34381  agccaacgtg taaatattga cagtttaata atctgaacca agccacctgg actgattgta
34441  atattttaat ttaataaatc ttgcatatgg ttaagattac atcttctaca ttcatcagat
34501  tggatttaat gcactcacca taatcaactc tggaacattc ttgcaattat tattgttatt
34561  tttaaaggtt ttctcctttg tctgttgttt tcccactttt tttttttttt tttaagacgg
34621  aatctccctc tgtcacccag gctggagtgc agtggcgtga tctcggctca ctgcaacctc
34681  cgccccctgg gttcaagcga ttctcctgtc tcagcctcct gagtagctgg gactacaggc
34741  gtgtgccacc acgcccagct aattttttgt atttttagta gagatggggt ttcaccatgt
34801  tggccaggct ggtctcaaac tcctgacctc aagcagtctg cctgcctcgg cctcctgaag
34861  tgctgggatt ataggcgtga gccactgtgc ctggcctgtt ttcccacttt ttaaagtaac
34921  agccttgttg agatgtaatt cacataccat atagtcacct atttaaagtg tacaattcag
34981  tggttttagt atattcacag aattgtgcaa ccatcacaac tatttccgga atatttttgt
35041  cacccaaaaa agaaacccca tactcactag caatcacccc cagttccacc attcctaggc
35101  agccatggat ctactttttg tctatggatt cgtctattcc agacatttca tagaaatgaa
35161  accacatagt gtgtggtcat ttgtgattgt cttctttctc ttagcgtgtt ttaaatgtag
35221  cacgtatcag cacttcttat tgccagttct gctgtatggc tataccacat tttatttatc
35281  aattcatgag ttgacagaca tttgggtcat tttcactttt tgcctcttat gtataatgct
35341  actctgaaca cttgtgtata ggtttttgtg tggacatatg tttttatttc tgtcgaatat
35401  atacctagag gtggaattgt tgtgtcgtat ggtaactcta tgtttaacct tttgaggaac
35461  tgccaggctc ttttgcaaag ctgctgtact atttgacatt cttgtgagca atatatgagg
35521  gttccagttt ccccacatcc ttaccaacgt ttgttattgt ctatcttttt gattatggct
35581  atcctagtgg gtgtataatg gtatctcatt gtggttttag ttggaatttc cctgatgact
35641  aataatgttg catgtctttt cacgtgctta ttggccactt gtatatcttc tttagagaaa
35701  tgtgtattta gatcgtttgt ccattttaaa ttgggttgtc tttataaaat gttgaattgt
35761  aagagttctt tatatattct ggattcaata catatgatac aatacatata atacatattt
35821  tagtcatcta tcagataaat gatttgcaaa aattttcttc cattttgtgg gttgtctttt
35881  tactttcttg atggtgtcct ttgaagcatg aaagctttta attttgatgg agtttattta
35941  ttgttttcta ttgtcacttg tgtttttggt gtcatattta agaaaccatt gcctaatcca
36001  agatcacaaa gatttcactt atgttttctt ctaagagttt tgtagtttta gctcctatat
36061  gtcagtcttt gattcatttt gagttaattt ttgtacgtgg tgtgaagtag gggtacaact
36121  tcatactttt gtatatggat atccacttgt cttagcatca tgttttgaac aaactgttct
36181  tttcctaatg aattgttttg gaacccttgt gcaaaaccaa ttgaccttat gtaaatgtaa
36241  gggcttatgt ctagactgtg tcagtatcac actgtcttga tttgtttaat ctatttttga
36301  ggcagacttt cgctccctga tctaaaatta aaatgtttca caattgatga tgtcttatat
36361  gcatcaaaac ttgcagactg ggtgtaagtg gcttgagaaa atatattgga gactaaagtg
36421  gggctgttgg agactcatag gaatcaaata gttagaaggt gggggagtga gagaggcagt
36481  aagttggatg cttcccaggt gtttagcagc catcccaaag tggcagtcaa aaataggcta
36541  gctttacata atttcaaagt taggtactga tggttccagt ttctttttat ggattctttt
36601  aaaaagtgct gtatcaccaa atgctgttga tggcatagaa gacaacactg tggaaaaatg
36661  tggacattga ccagtctgag tcaaaaagat ggacagatat tcagttctaa atgtgaggaa
36721  tttttaggaa aaccttgagc agttaatttt gcttatttcc ctttctatgt gtatatgaat
36781  gataaatgaa aagtctaaaa gagctccttt aataagcctg agataaatgc taagtcgtag
36841  actactgcat catatcttat ttggcttttt tttagtgcca cctaaaatac tggtgtttta
36901  gctttgagat gctcttatcc tcctgcttcc agctctatct acacctcaga aggagctggg
36961  tcctttccca gagtctattg tataaattaa ccttcttcct gtagtcactc tatgtccatc
37021  tgtttcccag ccactttaat tttgttcttt ttcctttctc ttgtgcttgt agatttaagt
37081  cttaaaaaca agccaggtat tattgtttat agtggaattt tgagtaggag tggaggttaa
37141  cctgtacatc aatctagtag gaatattcat tcaatcactc aagggatgag cttatggaaa
37201  agttacaaaa atagtagcat tcctttatat tcctcaccct gctcccttaa tgttaacatt
37261  ttatataaag gatcaagaat aggaaattag tcttggtaca gtattattaa ctaaactaca
37321  gagcttattt gaattccatc agtttttcca ctggtggtct atttctgttc taggatcctg
37381  tccaggatcc catattgcat ttagttatta tttctcctta gtctcatcca gtttgtaata
37441  atttcttaat ctttaatgac acctttgaag agtacagatc aatattttgt agaatgttcc
37501  tcaatttgta tttgtttgat gctttcttat gaataaggtt gttcattttt ggcaagaata
37561  taatgatgca tatttttcag tgtatcatat caaggagttc atgatgttga tgtgtcttgt
37621  tactggtgac atttaccttg attccttgtt taaattgctg tctgcagggt ttctctacag
37681  taaaattatt actttttctc tttatggtta aaatatcttg ggggagatgc tttgagacta
37741  ggcagatatc ctatttatcc tcaaattttt gtccattgat ttttttcatt ctttggtgga
37801  tcactctgta tcatagagta tttgtgacaa atatttgatt agcagaaata aagctatgcc
37861  ctacaagaag caaagatcaa ttacattgaa atcctattgt attggttaat ataacgctag
37921  cagctgtgtt cctcaacttt caggagctta acacaacaga tgcttttctt ctcaatatgg
37981  gcatttctgg ttgtgtaggc agttttctgc catgttaatt caagtatcca gactaaactt
38041  tttatactga agtaacttca aactgacaga aaatagggat gcaagaatag taccaggaaa
38101  tcctgtatac cctttactag atttacttaa catttgctac atgtgcctta tgattttctt
38161  tgtctattca tatatgtata tgtattttat atatatttta tatatctgta tttatatatt
38221  gattgccata tactaaatca cttgagatta aatcacatac atcatgttct tctatgcctt
38281  aatagtttaa acttaatata tttatttgtt taaatctagt atacagtttc agaattgcta
38341  acccatatct gtttgagaaa cactttcact aactggatta cagcatttat acaattcttt
38401  tattctttag ttttgcaata tctagtcaag atacgatttt ccagtttccc actgaagtat
38461  taagtttgaa aactgtacat aagcacactg ttattcaaat ttaggaaatt taatatcagt
38521  actttagtat gcagtctgta ttccagtttc attaattatc cccaaaatgt tcttcagtgg
38581  aatatttttt ttctcctgat acagtatcaa gtccaggatc atgtattgaa tttatttgtc
38641  atgacttttt agtttccttt gatctggaac agatcttata agcctttctt tgtctttcat
38701  gacatcgaca ttttgaacaa tgacaaattt atgacattgt tttgtagaat gtaccaaatt
38761  tgggctgggt gctgtggctc atgcctacaa tcctagcact ttgggaggct gaggcaggtg
38821  gattgtctga gttcaggaac tcgagaccag cttggccaac atggtgaaac cccatctcta
38881  ctaaaaatac aaaaaacaaa aaaaattagc catggcacct ataatcccag ctactcagga
38941  ggctgaggca agagaatcgc ttgaacccgg gaggcagagg ttgcagtgag ccgagattgc
39001  accactgcac tccagcctgg gcgacagagc tagatgctcc atttcaaaaa aaaaaggaac
39061  gtaccaaatt tgggtttggt tgatggctcc tcttgtttag attgagatta tgcattttta
39121  aaaaaacttt taggttcagg ggtacatgtg ctgatttgtt gtataggtaa attcttgtca
39181  cgggggtttg ttgtacagat tatttcatta cccaggtact aaacctagta tgcagtagtt
39241  ttttttttct cttctccctc ctgccaccct ccatcctcca ataggcctca gtgtctgttg
39301  ttcttctctg tgtgtccatg tgttctcatc acttagctcc cacttacaag tgagaacatg
39361  cagtatttgg ttttccgttc ctgcattagt ttgcttagga taatggcccc cagctccatc
39421  catgttcctg caaaggacat gagctcattc ttttttatgg ttgtgtagta ttccatggtg
39481  tatatgtacc acattttctt tatccagtct atcattgatg ggcatttagg ttgattttat
39541  gtttttgcta ttgtgaatag tgctgcaatg aacatacgct tgcatgtgtc tttatggtag
39601  aatgatttat attcctttgg gtctataccc agtaatgggg ttgctgggtc gaatggtatt
39661  tccgttttta ggtctttgag gaatcgccac tctgttttcc acaatagttg aattaattta
39721  cactcctacc agcagtatgt aagcattcct ttttctctgc aacctcactg gcacctgttt
39781  ctttttgact ttttagtaat agccattctt actgatgtga gatgttatct cattgtggtt
39841  ttgatttgca tttctctaat gatcagtgat gttgtggttt ttttttcatc tgctcgttag
39901  ccacgtgtat gtcttctttt gaaaagtgtc tgagattatg catttttgtc tggaatactg
39961  cataagtgac atgtccttct caggcaatgc atcaggaggc acatgatgtc tcaacccctc
40021  attggtgatt gtaattttga tcatttggtt aaattactgt ttgcttaagt gttaactatt
40081  tttagatatg acgtatcaga gtgatcaata ctgtgaagcc tcttacaaca gtgtttagat
40141  tgaaaaatta tgagtgaaaa gcctttcaca gtcattcgga ttgaatatgc ctaacatgaa
40201  atccaaactg tttcaacatt tctttcaagt cattttctac tatggaaata ataatgcatg
40261  atttagccat gcctgagttt tatttcctca cgcaggcatt tatttcttta aaaaatttaa
40321  tttaaagttc actataaaac ttaccatttt aaccatttga agtgtacact tcagtggcat
40381  taagtacatt cacaatgttg tgcaaccatc actaccatcc atctccagga cttctttatc
40441  atcccaaaca taaaccatat ctactaaaca gtaactcccc aattccttct ccagcccctg
40501  gtaacctcat tttatatgcc atcacaatat tttagaataa acgccaactt cctggggtaa
40561  gatcatttga cttttgctcc cagatcagaa ctatgataaa aatattattt gctatatact
40621  aacagggaaa tttctggatt ttggcatgag ttactgtatt ataactctaa atcctggtaa
40681  gggaagcatt tttattctga aagtaaacaa aaataaccat tagtatgata atctttacct
40741  ctgggggtgg ggtattttgg agggggtgag tacaaagaga ggtgaaatta ttcctctagg
40801  gtggcagacc agagtttaaa ttgtttctta Kgtttttcat cttggttgtc taccaattgg
40861  atatagtcac tcagatcatc catgtttttg tacctggttt gataggtata aatacctata
40921  aattggaata aattctagca attagaggtc catgttcctt ggtctgtaaa gtgaatataa
40981  caaaactgac ttctctccaa agggtgcttt gagacaaaac tataaaacac tttggagagt
41041  agaagggggg tccttatttt tagtaacatt cctcagtgtt cttcaagaac tcacctactg
41101  ccaatcattc ctctgagtta agaatatata ttagaactag ttttaatagc actataaact
41161  atagatagca tggccatatg tccctgtttg cctggagctg aataaattac aggttcaaaa
41221  atactcaaat aataaaattg cctaggtggt gacccaccta gtttgttgct gtatggtgtt
41281  gggtatctct tttttttcct tgacaaattt gaaaaggcct tgaaaccatg agcagattcc
41341  ttggttcaga tggtctgtaa taggagacac caggacaagc ctgagtctcc tgctcttgaa
41401  agattagcat attgatagat tgcRtaccca ttatcagtta ggtatctgcc aaaccatttg
41461  cagcgtttct ctggagttca tacagttggg aagacttcct agaggcaaga ggtcttttac
41521  ctgaagattc agcagttact ataggggcct tcttttggct tcttgctctt gggacacctt
41581  tacttgaatg aggtagtctt ttgccattag tgcctgtggg gccttaatga ttcctattgg
41641  gatgagttgg ccagaagtga ggctctccac ttcatgttga aactaacttc tgcctgagta
41701  ttaaggatgg gtgattctga ggtcctgagc cagctggaag gactttcatt cactttctac
41761  tcttgtctga agaatgctta ggctacctta ctgttacttc tctggtggta ccaaaggcca
41821  tgtaatgaca tggctggatg cgatcactca cgtctgtaat cccagcactt tgggaggcca
41881  aggcaggagg atcacttSag cccaggagtt caaccagcct gggcgacata ggaagacccc
41941  catctctaaa aaatttttaa aaaatctagc tgggcatgtt ggtRtactcc tgtagtccca
42001  gctactcggc aggctgagat gggaggattg cttgagctta ggcgattgag gctgcggtga
42061  accatgatca caccactgca ctccagcttg ggcaacagag caagaccctg tctctaaaaa
42121  aaaaaaaaaa aaacaaacaa aagatgtgat gattgcctct ttcggttata tcctgctgcc
42181  taagagccca ccccagaatt tagtggctta ggataaccat tttcatagtt ttgtcagtga
42241  gggattaggg aagatgtcag ctgagctctt catttctgct ccagatggca ttggttgggc
42301  aatgggactg gaggttctaa ttctaagata gcttcttcac tcttatgaat agctcctcag
42361  tgtctgtggc cagtctctct ccatgtggta tctcatccac cctggccttt ccacatgcct
42421  taggcttccc acatcatggt ggttcctggg tagttactct tcttacagag tagggatgaa
42481  atgaaagcct ctattctaaa ttcagttaaa tactggtaca aatatttagt actgggattg
42541  tgggatcatt ttcttatatc ataattataa cccaatcagg gtagaaaagt gaaagaaaga
42601  aggacacttc attttctttg ctctttgtgt ggatgatggg ttgtacaaat agcaggaggt
42661  tcaacttttg gcttgttttg gattactgag tactatcctt cagaaatgat ttcctaatac
42721  tttcccggcc atctggcatg agcacagaag accttttact caataaaagt aagctaataa
42781  taataagttg aaacatcttg ataataaata tatttgtaca gcttttcaaa tcccaggtta
42841  ttgaaattct gtcagccttg gctggtttcc atgctccttc tgtgcccttg tgtttccttt
42901  ttttcttttt ttttttgttg agccactcct gctgacttcc aaaggatgct ctgagctcta
42961  aaaggaggag cagttttgct ggcatgcaga agtggtgaag gtaaggcttg gattcaatta
43021  cagtaatctc agaagttctt ggtagaagag gggcacagaa tcccagcctc cattttgcag
43081  gtaaggaaga agaattataa aaagataaaa tggcttttct taatgtcagc atctgattct
43141  ttaccttctt tcaccctagc aaagattgtt aacataaaac agatgttcct tggacaagag
43201  aaaagtaata gagctggatc ttttcatgat cctgcattta ttatttgtag cactggatct
43261  ctaaactagg aaaagcaatg tcgattctaa ctagaaatta tggggcattt aataacacgt
43321  gaggcaaaat tatgaggaaa ggcaagaaac caagtggctc ctagcttcta acaccttatt
43381  ttctatggtg taagttaatg aatgatccat ttttaatgcc ataaaaaagg aaatttccga
43441  taggctttac cttaacttca cgttgctgtt tatattacag acaaaatgct aaagttaaca
43501  agtgtaaaat gccctaggtc agggtttcga gtgcccataa gcaattctct agaattattt
43561  tgagtgctca gattatagat ttgcccccat accatatact gtattaccta tcactgcaag
43621  attctttata gggtgtcaag tatgtgggag gatttaaact aattgtctta aatgcttcat
43681  gggataggag atgatccaat gggaactgaa tgttttcaat taggatgttt ccatggatac
43741  tattaagcat gccaagattc atagccacag gagattttta cttacttcaa tattgattaa
43801  gaaatctgag aacaatctca agaagtgtag gatgtaggcg gaggataaat tttgaggata
43861  gtctaaaatt tgctttctct tccatagtta aggcctagtc cagaaaaagt ctaggcagtc
43921  agccaagtct aacagcagga tttatgtcaa gagaatgtcc agaataaaag tgaacatggg
43981  ttgtttcatt taccccaggt gtatttatta acatttattt aatgttactt attatttgtt
44041  tattaccatt agctttctta tgtactcggt acaaagcatt agaattacaa ccctttgtat
44101  ctttgttgtt tatgaggaaa acatcctaaa tagtgtctac agacatctta aaattcacat
44161  tcctctgaga aaggtttatc ccttaggtta ttactttttt ttttttttcc acacatgggt
44221  tttttacctg ggttctcaga tctccaagaa atcggtggat agaattcaag gtgacttctt
44281  ggatggagaa aaagtacgtc tttattttga ccaaccatgg atatttagca ttttcatcaa
44341  ttaatgaatg caggtgacaa atcacagtac tattggcccc atctttgagt ttgtcctcaa
44401  tagctcacag atattttcat attgtatcac agttgttgca gatatcttga aatattgttt
44461  attctaatca ctccttcaaa atttgggtgg ttattggcat tatcaccagt tttttttttt
44521  tttttgaggc agtctttctc tgttaccccc aggctggagt gcagtggtgt gatcttggct
44581  cactgtgacc tctgcctccc aggttcaagt gattctcccg cctcagcttc ctgagtagct
44641  gggattacag gcacatgcca ccacggcccg gctaatttat ttatttattt attctttatt
44701  ttttattttt aaattttttt tagatggagt ctcactctgt cgccaggctg gagtgcagtg
44761  gtgtgatctt ggctcactgc aacctccgcc tcccaggttc aagcgattct cctgcctcag
44821  cctcccgagt agttgggact acgggagcgt gccaccacgc ccagctaatt tttctatttt
44881  aagtagagat ggagttttac catgttggcc aggatggtcg cgatctcttg acctcgtgat
44941  ccacctgcct cggccaaaat gctgggatta caggcgtgag ccaccgtgcc tggccacatt
45001  accaccagtt cttgatactt aatgccataa caaaaggcac atgtatcact atatcacaaa
45061  ttagcatttt ataatatttt aataacgttt tcaatataag tggcttccct tgtaatcata
45121  tattttattt ttgcacttaa aaatataatt cctaaaaggg atccataaag cttcaccaga
45181  ctgccaaagc gtccatggca caggacgtta agaaccctgt tccaaatgga atgaagatta
45241  gaagcactat catatgttca ttttctgatc gcagtttaag aaagagtttc ctacttaagt
45301  gcttttcaca gaaaatctaa acttaaaggt taaaagggaa ttcttttgtg ctggctcatg
45361  tgtgggccct acaaagtact ttgcagtcat atctgacttt cgtttgagag tttgtcttca
45421  gaaatggaag aagaaaaggc attcaggtat atgacaggtt gcattctgta gaacattgtt
45481  aaatctatgg gaggggagaa aagttccatt cagtgtcttg tggattgtgg taggagtcag
45541  ttgtgttctt gcagaaattt ccctagacag tgcctcttgc ctcctccttt cttgtcccac
45601  agtactccat ggagcagatg tgggaacttg gatgcctgat gggaattgta accccatgct
45661  ttgccttatc ctggtgggga ctgatctgag gtttatccat taaactgtat cagttcatgg
45721  ctgggagtag gaatgcagaa aacacaagca aaatgactgc aggaaggttt aaataaaatc
45781  tcatatgtgg cttttcctta acacattatt ttgcaaaaag tggcagagtg aatttgctgt
45841  gatatgatag gatcattctg gacttttact taatttacgt gttctctagc agaatgctga
45901  aggagcacac ataaggagtg gggagttggt atttggttct gtgacaagtg ctatcttata
45961  acagaaaaat acatattttt gtgaaacttc aaatgcattt ttattcccca gcacatctgt
46021  gattctggat ccactacctt cttccaagtg tgatcaagca ctgtacctga cagtatcgat
46081  tatccttacc cgtaggcaaa aattgtatta catttatttt acagtgatct ggaaaaaaaa
46141  ggatgacaac aaaaaccaga cacacttcat ttctattccg gtaacatttt ttggtaataa
46201  tttattactg tacaagtcac acaccatata agtcacacat ttaaagtgtc aaattaaatg
46261  gtttttagta tattcacagg atcgtgccat catcacagtc aaatttagaa cacttattac
46321  ccccaacaag aaacctcata cgctttagca gtcaccctcc attgcccccc agttttctaa
46381  ccccaggccc taacaaccac taacctactt tctgtctcta tgaatttgcc tcttctggcc
46441  atttcatata aatggaatta cacattttgt aaccttttgt gactggcttt tttcacttag
46501  cataatgttt tttaaggtct acctatatta gagtatgtat cagtacttta ttccttttta
46561  tggccaaata atattccatt ttctggatat accagatttt gtttatccat tcatctgttg
46621  atggacattt gagttgtttc cactttgtgc tattattatg aataatgctg ctatgaacat
46681  tcatgtttac atcatgtata cattttaatg tggacatatg tttttagtta tcttgagtat
46741  atacctagga gtggaatcat atatatatgt ttttaaacca aaatcaaatt ttaatgttgc
46801  agaatccctg aagcactttt aggaactgtt cacttccata gaacagtttg caaatcagtg
46861  ttaaagtgga gagagtgttg atttttttgt gcatgtattt ggtagacatc gtttgaatct
46921  tgattttata ggctgtgtga attttgtcaa gttacctgtg aacatctttc ttctagtata
46981  gaatgttagt acctctggat gtttcacgag ttgatagact gtattattgc ttgaaaaatt
47041  cactgtccat ttattaccat caactttggc cacggatttg ctttggctag tggcctgtga
47101  ggggaagtga tgtgtgcctt cttccaggca gaagctggtg gtttgcctca tctcttttcc
47161  tttctgccat gatgaccatt gatgttccag ttggacacag gctccatcag cttgtgtatc
47221  agaatgaaaa tgatgtgggg cagagccctc atagattttg ttgcatgagt atggaaaaag
47281  tgtcatttta agccgtcaag atttggtgac tatttgatac tttagcacag tggtcctcaa
47341  gcaatggcag ttttgcattt ctcacactga gatatctggc aatgtctgga gacatttttt
47401  ggttatcaca catggggaag tgctcttggc atttagtggg cagatgctgc taagcatcca
47461  acactgcaca ggacagctcc cacaacaaag aattatctga tccaaaatgt caatagtgct
47521  gaagtttaga aaccctgctt tagtataacc tagtttatcc tggttaagat agggtgttga
47581  gaagattaaa tggaaaaaaa atatataaaa tacagcacac agggtggtct ttttttggta
47641  attatgtgac agagcttggc aatggctctg aggtcttccc ttgcatttgt gggtcttttc
47701  caacttccct agggttcagt attcagttta attgtagttg tgtttataaa tcaaggctcg
47761  tttttagcag aatcatatac cctttaaaaa agggggagaa ctaacattag atgcctgttt
47821  ggcaccaggc tctttgtatg tgttttgaat ttttacagat attctctgaa actgatattc
47881  cttacctcca ttttgttttg ttttgttttg ttttgttttg agacaggatc tcactgtgtt
47941  gcccagactg gagtgcagtg gtgcgatctt gtctcactgc aacctccacc tcctgaattc
48001  aagcaattct cctgcctcag cctcctgagt agctgggatt acaggcatgc gccaccatgc
48061  ccagttaatg ttttgtattt tcagtagaga tgggatttcg ctatgttggc caggctggtc
48121  tcttaacttt tggcctcctg tgatccccca gccttggcct cccaaagtgc tgggattaca
48181  ggcatgagcc accatgcccg gccctccatt ttgtttttga tgaagacatt gaggcactga
48241  agttaagtaa tttgaccaag atcacatggc ttataagtgg tgggcctaga attcgaagca
48301  catctgtttg cctccagaac cctcttcttt ccacactgct atactacctc tttagcagtg
48361  actttaacat agagaaatga aggtaatacc tgatttctaa caattatgtg ttgtattagt
48421  tatctattgc tgtataacag gttacctcaa aacttagcac tttaacacaa caaacagtta
48481  ttgtctgaca tagttttgag aatcagtaat ttaggggaag ctaagctggg tggttctggc
48541  tcaggatctc tatggagatt gcaaacaagt tgtcttccag ggctgcagcg atctgaagac
48601  ctgattggag caggaagatc cacttccatt gtggtgcact cacagggctg ttggtgggag
48661  gcctcagttc ctcaccatgt gggtctctct ttagggttgc ttgattgtca tcatgacatg
48721  gcagctggcc tccttcagag tgagggatct cagagagaca gcaaggcaga agccacaata
48781  tcttttgtga cctagcctta gaagtcacag atgatcactt ctgctctttt ctattggtca
48841  catacacaac cctgatataa tgtgggagag gatgatacaa gggcatcaag aatactatga
48901  gatggaaatc actgggggcc atcatggagg ctggttacta catgttaatg atcctcattt
48961  gccatagtta caaaattatg aattatattt ccttttcata ttctaatatt ccaaacacct
49021  gttttgtact ttaagatact taaatcattt agaatgtgag tgaaaataca aattggcttt
49081  tgtaaacact tactgaatgg gtaaaataaa ggccgtggta cagatacttc attggggaat
49141  ttttttttta aataggtttg actagctgag gcttcttgaa tcctgaaaag tttggtctga
49201  tgtacttttt tttttttcct ggaaaatctc cttgtaccaa acactgaatt cttcatttgc
49261  caaagtccac ccaactttct gatgttttta ttgctggttt gatgtgcttg aatgccagcc
49321  agagtataag gtgaatggta gatgcaagga ctgtgcagtt tccacggaga cttctttcag
49381  gagcccttca ttttttcatt cagctattgc tgggaggcat ccccttccag ttaatgtgtg
49441  gtacacatca atttgagtgg ctcttagaaa ggggctcagt ttatacaaat taagaattga
49501  ggtttttttt ttctctgtat atcttcaacg ttaaattaga tttctatgaa acttgaagat
49561  gttaacagga aatcttcctg aaacagttta actatacttt tgtttattac acttgatttt
49621  gagcttttgg gaataaaagt agggtcctgg ctaggtacag aggtatatgg atttactgtg
49681  tctaatcgtg caaccatgaa ataaacgttt gcacttcagg aatcaaccca tcacttttta
49741  accactgttg tttgcattgg cttagagctt tgtgcttcct tcaactattt tccttttttc
49801  tttcaaaact gtgttcagtt ggttgtgacc aattttacac agagactggc tcactcactt
49861  atgttcttga ctcctgctgt cccaatatca tgcttcattt acacagggat agcttttcct
49921  ggctttatct gttgacttga catcctgtgc atcatatttc ttttcttaga tatagagaag
49981  actgaaaaaa atccacgatt tgaagaaaat ttRcaaaagt gcagagcaat gtgaaagaga
50041  tagctttaat tttaattttc actgtagtca gaataggtgg cctcctgatg ggcagacttg
50101  ctttctcatt ttactctgtc cagtgtagat acccagatca atcaaggtca agctggtctg
50161  gtcattaata caacttttgg ttttaaacac agctgtgtac gggggttctt agcattatta
50221  atagaggtta taatgaaaac aaggtatagt catacagttg tctgtgtggg tagtggcatg
50281  gaggtggagt tgttgcttaa gatctgaaag tcaggaagct ggaggttttt gtaattttat
50341  tcattatcaa tcttaagaat ttattttgat cattataaat gcatgactgg tgctattttc
50401  caatcctgag gttttttggg aaattttttt gaaaagaggc caggatgagg ataaaaatta
50461  attttgaaaa tccatttcaa agactcatta tgctatgctc catcactgca attttaatgc
50521  aacttatata ttgtgctttt acctttggga ctagcattct taaaagctga cttttaattt
50581  ggactttcta atatgtgtcg gctctgtcag ctcacgagtg tgtttttatc tStgcatcat
50641  gttatattgg gacctgggtg gaatgtaaat cttttactgg cctaaatctg agtctaatcc
50701  tctgcatggc tttggtagaa aatcaatttc ctctgctctg tcaagatttt tcaggtcagt
50761  gctctttgga agtttcccag ttctcttaga ttaaaataga ttttgtttct gtgctacata
50821  ctggtattag ttagtaggac actgggatct aaaagcaaga gaacagaggc agacaagata
50881  tccatgagtt cttctatttc agttaacttg ttgacacact gcacctttga ggaaccaagg
50941  agtttgtgtg ctttcaggca tcatttgggg gagcaattgt aaatgactcc tgtaggtgag
51001  gctgtgcact taattttaat gagttcaggt tcattaagtg acctgctcac tgggtcatta
51061  gaagtgacct cactagaagt gaatggtaaa gagaagaact acctaagttc cactcagctt
51121  gtttcactac tgtggggtat tggaagtaga gtgacaactt ggactttctc agttttagca
51181  ctgaaaagtc ccacatccca ggaacttact cagtccccag caaactaggg ggagcggggg
51241  atggttggtc cccctagcag tgaaaagtaa ggggatggat gatttggaac tggttagtac
51301  ccttatagat tttttttttt ttttctgaga caggttcttg ctgtgtcacc caggctagaa
51361  tatagtggca tgatcatggc tcactgcagc cacgatctcc tgggtccaaa tgatactccc
51421  acttcagcct ccccagtagc tggaactacg gggacaagcc accacaccca gctaattttt
51481  atttatttat attaattaat taatttattt ttttgtaggg acagggtctc gctttgttgc
51541  ccaggctggt cttgaactcc tgggctcaag tgatcctcct gccttagcct ctcaaagcac
51601  tgggattaca ggtgtaaacc accatgcctg gctgtcttat aaatacttta aggagggatt
51661  tattagagac atgtagcacc ttgctgccca gtgatgctag taaatgagtg actctacttt
51721  gatttgacag aagaaacaat ggaaagagga gagatggaag tttttctacc taaacttcct
51781  aagaggatgt gtttagggga tgtgttggta aaaagttatt agcattaatg tttacctgta
51841  tctttctcat agataatgca aagaccttta actccactta tccctccttt taacttatgt
51901  tgttattgcc ttgtatttta atactatata ttaaactcta caagacatca ttattttatg
51961  caggcattgt ttatttaatc agagttcagt aaactttttc tgtaaatgcc agatggtaaa
52021  tattttaacc cctgcaggcc ttatagtctc tgtcacaact actcaactcc actcttaata
52081  gtgccaaaat ggctatagac aatatggaaa tgattgtgtg tacccatgtt ccaataaaat
52141  ttatttacag aaacagacag tgggccagat ttggcctgca ggccttactt tgacaactcc
52201  taatttagat ttatctacat atttatttat tttcccttta tttcttgcta tatctttgag
52261  gttctacctg ggatcatttt caaggcaagg atgtctattc tcatcactgt ttttcagcgt
52321  tgtgctagaa attccaacca gtgcaataag gcaagaaaag gaaataaaag gcatacagag
52381  cagaaaggaa aaaaaaaatg aaactggcca ggtacagctg ctcatacttt gagaggcgag
52441  ctaggaggat tgcttgagcc caggagttcc agaccagctt gggcaatgta gggcgacccc
52501  catctctaca aaagtaaaaa taaaaaaaaa attagcaggg tgttatggtg catgtctgtg
52561  gtctcagcta cttgggaggc tgaggtggga ggatcacttg ggccttggag gtgaagtgag
52621  ccatggtgac tgtatcactg cattctagcc tgggcaacag agtgacaccg cctgtctcag
52681  aaaacaaaac aaaaacctgt ctctatttgc agatgacatg attgtctaca tagaagaccc
52741  tgagaaatct acagtctaca gaataactcc tagacctaat taagtgagtt cagcaaggtt
52801  tcaggatata agataaacat acaaaaatga gttgtatttc tacatactag ccataaacaa
52861  atggacactg aaattaaaaa tacaatacca tttacattca ctcaaaaaat acttgggtat
52921  aaatctaaca aagcatgcac aggacttgta tgctgaaaac tatacaatgc tgatgaaaga
52981  aatcaaagtc taaatagatg gggaaacata ccatgttccg ggtttcagga tataagataa
53041  acttacaaaa atgagttgta tttcacatac tagctagaaa caaatggaca ctgaaattaa
53101  aaatacaata ccatttacat tcactcaaga aatacttggg tataaatcta acaaagcatg
53161  cacaggactt gtatgctgaa aactacaaaa tgctgatgaa agaaatcaaa gtctaaatag
53221  atggggaaca taccatgttc caggattgga agactcaaca tagtaaagat atcatttctc
53281  ccccaaattg atatacaggt ttaatgtaat tcctgtcaaa atcttagtaa gatttttttg
53341  tagatataat tataaaattt atatggaaag ggaaaagaac tagactagct gaaacaattt
53401  tgaaaaagaa taataaagca ggaggaatca gtctgtaaga ttttaagaca tataactaca
53461  gtaatcaaga ctgtgtgata ttggtggagg gatacatgta tagatcaacg gaacagaaca
53521  aagaacctag aaatagacca acagaaatgt gcccaattga tctttgacaa aattgcaaca
53581  gcaattgaac ggagaaggaa agatagcctt tttgacaaat ggtgctaggt caattaaaca
53641  tcaatatgtc aaaaaaaaaa aaaaactctt gctgtaaata gtacacgtta tatgaaaaat
53701  aactccaaat gtatcacaaa cttcaatgta aaacataaaa ctataaaaat aattagagaa
53761  aatcttcagg atctaaggct aggcagagtt cttagacctg acaccaaagg tatgatccat
53821  aaaagaattg ataaattgga tttcatcaaa ataaaaaata cttactctga gaaagacctc
53881  ataagaggat gaaaagacag actacagagt ggggggaaat atttgcaaac tacgtatccg
53941  acaaaggact ggcatctaga atatataaat aactttcaaa acttaacagt agaaaacaac
54001  ccagttagaa agtggaaaaa atacaagaag ggacatttca ctgaagagca tatacagatg
54061  acagataagc atgtgaaaag atgttcaaca taattagcca ctagggaaat gtaaattcag
54121  accaaagtga gctatcacta catacctata agaatggcta aaattaaaaa tagtgacagc
54181  atcaaatgat ggcaaggctg tagagaaatg gaatcattca tactttgctg atgggatgta
54241  aaatgataca gcccctctga aaaacagttt ggcagtttct taaagacact aaacatgcaa
54301  ctaccatatg acccagcaat tgcactcctg ggcatttatc ccagagaagt gaagatttat
54361  gttcatataa atgccagtat gtgaatgttt tataggagtt ttattcataa tagcccataa
54421  ctggaaacaa tacagatgtt ctttagtgga tgaatggtta gacaaactgg tatatccata
54481  gcatggaata Ytacccagca gtaaaaagga gtgaagtact gatacatgca atgatctgga
54541  tggatctcca gagaattatg ccgagtgaga aaagccaatc ctgagtggtt taaataccat
54601  atgattccat ttatgtaaca ttcttgaagt gacaaaatta tggagatgga gaacagatta
54661  gtccatgcca ggggttgagg gggcaagggt tgggagtaaa atggatagct ataaaaggca
54721  tgatgaggcc aggcgtggtg gctcacgcct gtaattccag cactttaaga ggccgaggcg
54781  ggtgaattgc ttgaggtcag gagtttgaga tcagcctgac caacatggtg aaaccctgtt
54841  tttactaaaa atacaaaaag tagctgggtg tagtggcagg tgcctgtaat cccagctact
54901  ccagaggctg aggcaggaga atcgcttgaa cctgggaggc agaggttgta gtgagctgag
54961  attgtgccac tgaactccag cctgggcaac agagcaagac tctgtcttag gaaaaaaaaa
55021  aaaaggcatc atgggtcctt gtgagcatga aaatgttctc tattgactgt gtcaatagag
55081  acacacaatt atgttgtgtg tcacaaccat aatcacaaca ttatggttgt gatattgtac
55141  tgtagtttta caagatgtta ccattgggag gaagtgggca aagggtacat aggatctctg
55201  ggtatcattt cttacctctg catataaaac tacagttgtc tcaaaaggtt taattaagaa
55261  agtatttaag aaaaagaacc ccaggatcta aaaagatcag agtcagagaa tcacaaatgc
55321  taaataagaa gcacttttgt atttggtgat gttctgaaat tctggctcag ttttgttatg
55381  aaatggagcc acgtgggtcc atgtgagtga gtccctgtgc aYaggtgtat gattgacttt
55441  ttccctcaag tgcttctaat ttgggatgtt cttcactgtg tgccctttga gtgtctcttg
55501  cctctggttt tttgttagac aaaaaaacca gtttttaaat gtcagttcca aggtcttttc
55561  tgggtacggt taacttttat gatttcattt atgcagtggg ttttcaccta agggccatgg
55621  tttctagaca ctagactcgt ttttcccaag cgattcatct ctttgcctgt gggatggaga
55681  gattcattct cttcttctct tttgcagtag aaactccagt tttgagctgg gcacctggat
55741  gcccagagta aaggttgtac tgcccacatt tcattgtagc taggtgtgcc tgcgtgacca
55801  agtatgaacc ttctatttag attaagccac aagataagtg gagctatcaa ttggctttaa
55861  caaatattta gtgaataggt aaaataaaat actttatata agagctgtgt gttctgggtt
55921  gaattgtgtc ccccacaaaa agatatatta aagtcgtaac ccttagtacc tcagaatgtg
55981  accttatttg gaaagagggt ctttgcagat ataattaatt tcaggtgagg ttataccgga
56041  gtagggtggg ctcctaatcc aatatgatga gtgtcctcag aagaaggcag tcaggcacat
56101  gtaccctaaa acttaaagta gaataaaaaa taaataaata aataaataaa taaaaaagaa
56161  ggcagtcagg tgaagacaca gacacacagt gggaaccccc tatgaagatg aagatagaag
56221  caatgtatct acaagccagg gaccgcctgc ggctgcaaga agccaggtga gacacatgga
56281  gctgattctc cctcacagcc cttagaagga acgtgccctg ctgacacctt ggttttggac
56341  ttccagtctc cagaaccatg ggataataaa tacatttctg ttgtttgaag ccacccaatt
56401  tgtggtactt tattatagca gccctaggaa accaatatac tatgcttttg atattatttt
56461  taggatgttg tggtttgaat atttgtgtct cccccaaatt cctatgttga aacctagtct
56521  ctgatgcgat agtattaaga ggtggggcct ttaggaggtg catgagggca gagcccttat
56581  gatgggatta gtgttcctag aaaagagact tgagggagct tgtttgcccc ttccagtatg
56641  tgaggataca gcaagaaagt gccatctatg aggcagagag tgagccctca ctatacactg
56701  aatctgctgg caccttgatc ttagacttcc cagcctccag aatggaaaga aatttctgtt
56761  gtttataaat tactgagtct aaggtatttt gttgtagcag ccccaacaaa ctaagacatg
56821  gagtatttta aaaaatgggt tgaacattca gaggcttctt aatctgagtc cttagatatt
56881  tggactgact ctgccttctt tttccagtga aaagatctcg ctgtatgaaa catagacatt
56941  cttcattgcc ccaaagccct tccaccttcc ttatgttttt attgctggtt tgatgtgctt
57001  gaatgctagc caaagtataa ggtgaatggt agatgcaagg actgggcggt ttccatggag
57061  acttcttgca ggagcctttc ctttctcagt tcaacagttg tcaaggaaac atctagtttc
57121  aattaaataa atgtttgtgg ggtctgccaa tttgagtgtc tcttggaagg ggatttggtt
57181  aaacttctta aacatcgtaa taaacaaatt cagagcagag gctttttagg ttcccttcca
57241  gttatattag gtttttctgt aacttaggga tgttaactag tcctctgtct gaagtgatca
57301  gactatttat tcatatccag aaaatattat ttttgagtct tgtggggagg aaaactgagg
57361  cttaaagaaa gagaggccaa agccagggag ctggtgttac atggcaccag ctatatatac
57421  atgactatag tccatgctct ttagtacgtc ctgcaggata agagatccaa ggggcctgac
57481  ctttacaaac tgtttacagg ctatggagtt tgctggctca gcactgtgtg tttattgctt
57541  ctagttagct attgttgtat cagtggctgg agttggtgat ggttcacgga aatagtggtg
57601  agagtacaga ttctaggtat atgcaattct aataaatgag acttccctag tgttatctgt
57661  attgtgacag cctccccatt gtgctcttta tcaaacagta aggtatggta tattgcaaaa
57721  tgctcacaat actttgcaac tcttcccatc aagaggtaga gtcagtttct ctattcttag
57781  gatcttggct gtcctgttga tttggtctga ccctggaata cagtagaaaa gaccctgtgt
57841  gggttttgat cctaggcgtg aggtagagct tcagtttctt gctgctttgg gaactctgcc
57901  accttgtaaa aaaagccctg gctggcctcc tggaggaaga gagactatgt ggaggaaaat
57961  gaaggtaccc agacaaccca atagtcaact gcagaagcat aagtgaccct catctgagat
58021  caatggtgcc tggctcggat cagtataatt gtccagctga actcagccca aattactgac
58081  ccccagagtt atgaattaaa taaatgctgt tgctttaagg cacttaagtt ttggggtggt
58141  gtgttataca gtagtagata attgatacag ccaagtttgg aagctctgga atgatcaggg
58201  ctcacctttg acctgtcctc tataaaaccc aggattctta gtaacacagt cctgttaata
58261  acagaacttg cctatggcaa atctaagcgg aaaagcagtt tattggcagg atattgtgta
58321  gctacatctt tctttaggaa gaccagggac aaggcttgaa aactgcacaa ctagggggca
58381  gtactgccag aactacagcc agataacctc acagaattgg tagctactga atattggatg
58441  cctccaccta caccaccaac attgcctgca ttggacattg ggtatggggc tgctcctgga
58501  actggatgtt gttcctgtca ctagaaaaca atcatctact gttcttgctg tttcacagca
58561  ctcattactg attcagatgc ccgtgtgcca cgtgtttata gcagtgcaat ttgtaattgc
58621  aaaaataggg aaccagccca aatgcccatc aatcgagtgg ataaagaaaa tatatcaaaa
58681  atatatttta tatgtgtgtg tgtatgtata tgtgtgtata tatgtgtgta tgtatatgtg
58741  tgtatatata cacacacgta catatatata catatatata cacacacgta catatatata
58801  cacacacgta catatatatg cacacacaca tatatataca cacacgtaac atttataata
58861  cgccatggaa tactactcag ccataaaaag gaatgaaata atagcatttg caacaacgtg
58921  gatggagttg gagaccatta ttctaagtga agtgactcag gaatggaaaa ccgaacgttg
58981  tattttctca cttataagtg ggagctaagc tatgaggatg caaaggcata agaatgaaac
59041  agtggacttt ggggcctcag agggaagggt gggaggtgag ggataaaaga ctacacattg
59101  ggtacagtgt acactgctcg gctgatgagt acctcaaaat ctcagaaatc agcactgaag
59161  aacttaactc atgtaaccaa ataccatctg ttcccccaaa gctatttaaa taataataaa
59221  aacaaaaaca aatgcctgtg tgggtggtgt ctggcagagc gtaggtcttg tgcccatacc
59281  ctgattgaaa agaaatcagg aaagtgagaa tctgacactt ttagcttatt tagctgaaag
59341  caggtggaaa atttcataaa cactggcaaa gggttcggat aacaggcagc caaaagaaaa
59401  atggcaaatg ttcattagtt tctgttgtat actctggtta gctcagttgg ttacagcaca
59461  gttatgatga agccagcatt gtggtttgtt cttaagtttt attgaaagaa aatagttctg
59521  agattgtccc ccttacacct gctccctctc tcacagatgt gtgctgatag ccatttgtaa
59581  ggccaggcaa tagtggggcc taacttgcat ctgtctctgg ctgctaaggt acaaagatta
59641  tgtgtctttc agttggtggg cccagagact ccattcactg gcatagtgtg ccacataaga
59701  gaactgaatg aatggtatct gtgtgaatct aaggggttgg ctaattgcgc agtgaatttg
59761  gttcatgtaa catttataat acaaattgtt gggcagcaag atctttcaat ccagacggtt
59821  tctagttttt cagaatttct ctgataactt ctctgaactc tgaaattctt atttgcaaaa
59881  ccatctatat agggttcatt taaatattag aaatagtact cataaagaga aaagcataat
59941  gcctagagga tgtgtaatag atgttcaata aatgttgatc atttccctca aacttcttag
60001  attcacacac cccaaccaga ttagaaactc tgacacggct tgcccttttt gtgttcaatt
60061  ctctctcagt tgttaagtga agacccaatc cagttgttaa aataataaat gcacctcttg
60121  cctccctgac attctggcaa ccttactctg aggaggctgg cccggttcga agctggctgc
60181  tccagggcac taaagctgga gaagggccct tccaccctgt tcataactgt ggacagtaaa
60241  ctgtatttgg gatagaggat cttgggaaca ataaggacct agatccaagc tcatgcattg
60301  tggtgggact gtcaatttag ggggatgggt agattttatc agatctgtca gtggaaagtt
60361  tggggagatg gaatagtatc tacaggtagt tccaggtagg aggaagagat ctacctggct
60421  cctagggatg tccatcctgg caagcattgc tcagtggcag gagttgtaag agtagggaag
60481  gtttaggaat ttggatatca gggaagtgtc agcaggtagc tggggatgag gtgcaggaca
60541  aagacagacg agaggaagac caagccttaa agtgatgagt atctagatag ggaagaggat
60601  ggatgggtat agcttggaca cagaaagggg attcagtcat ggaaagaggt cagtctgcaa
60661  tgtaatgtgg ctatcaggtc acaggagggc caagagcagg acaggtttgg ggcttggttc
60721  tggttagtcg aggcagagcc ccttagaggt gtttggattt gccatggtga tgcaggggac
60781  ctgagtgtgc tggttgtcat gagatcttgt tgctgggaga acagtcaaga acagggtaga
60841  aaggcccttc cccagcttta gtgtgccttg gagcaggcag ctttgaatag ggccagcttc
60901  ttcagagaga gctgccagaa tgtcagagag gcgagaggtg catttgttat tttaacaatt
60961  ggattgggtc ttcactggga gctctacaaa gaaaccaaat tagtgaagtt agattgccta
61021  tcccaccaac aatggatgtt tatggtatga gtttagctct gtgctagaga atctcaatat
61081  atttagattt gggcttgaga gagagaactt cagtgtgatc tgagactgaa cttccattca
61141  cattcattcc tcgaggaagc atgttgagga tctatgtgta atatactggt gttccattta
61201  cttgaaatat cctggcttgc tctattcctc tcacttaggc actcactcct ctaaaaaata
61261  aatgtgtata tgtgtatgtg catgtgtgtg tacatgtagg tgtaagtgtg cataaaatat
61321  ggaatagact gaaatcaaca aacttataaa aataccaaat aacctcaatc tgtaatttta
61381  tttttgagaa gcactaaaaa tgtcaataaa tgaattgtct gaaaaactaa tcctttggct
61441  ggtgagataa gtctgagttg ccagaaccag ttaaagcttt atataatttg gcagtacatt
61501  tgcgttcacc tgagatttct ctgcctccag ctgtacaaaa attctgtgat atgcagagcc
61561  tcgaaacctg ggccagaatg ctaaaactaa ttttctttcg taatctgagc cgtaattgca
61621  ttttaactca gttctagtgt gaagactgct tttgtatgtg tgtgtgttta cttcatgtca
61681  ttaatttctg gcatttaagt tagtgcctgg cacatagtct accctcagta aatgttagtt
61741  cttactgccg agtctactgt tctttccttc taaaccagtg gggtagatgc ttcctttgtg
61801  cctcagtggt tcattccctt gccctcttcc cctctcctca cccttgagtt gttagatcct
61861  ggttttgccc caggcaggtg ccaaccccga ggaactcctg accctgtggt gatgcatgcc
61921  tgcatgtgtg cagccagctg ggcagcttgg aaagccatag tattgacttg ccaaataagg
61981  actagtttac aaaagtcata agagatcact gtcatcaact gctatcacta tctattatcc
62041  tttctctttc caaaacacaa tttaggtgca taataaaaac atctgtagaa ttactctgtc
62101  aagcctatgt atgcccatca gttgtgcaag agcctcagtt cctacttcta atgaatttta
62161  tactgattat cccagacctt tctgccagct ccctaatagc agaggagaga atacactgtt
62221  ggagtcaggg gcaaccaaag cagctagtct gagtatagaa tttctttgaa ttctcatctt
62281  taagaaccat gctcagctgg gcacagtggt tcatgactgt aatcctagca cttcgggagg
62341  ccaaggtggg aggatagtaa tggcctggtg tggtggctca tttccataat cccagcactt
62401  tgggaggcca aggtaRgcag attgctggag tccaggagtt caagaccagc ctgggcaaca
62461  cagggagacc ccccatctct acaaaaaaac aaaaaagtag ccaggtgtga tggcacttgc
62521  ctgtagtccc agctatttgc agagggctga ggcgggagga tcacttgagc ctgggaggtt
62581  gaggctgcaa tgagctgtga ttgtgccact gctctgtagc ctcgaggaca gcgtgaccct
62641  gtctaaaaaa aaatggatga tatatccaca tgattcagaa ttgaagaggt acaaaacaat
62701  aaccaataaa ctctttctcc ccactgtgtc ctagccacct tgttttcttc cctggaggca
62761  tccagaagcc aattttgtta gtttcaactt ctggagatgg cttatgaaaa tataagtaaa
62821  tgcatctata ttcaacccca ttttagaaga aatgatacct actatatcag ctgctttctg
62881  tgcaccttgc tttttttctt tttcacactt tagcatgatg atttttctgt attggcacat
62941  aaagagcttc ttctttgtta gttggtggtt cttatggcag acaactgaat ccaccctaga
63001  tggttaagcc aaaaagggat tcggatttta ggtaactcat ggaatccttt ggagggctgg
63061  aggaacaggc tagcatccgg gtgcccagaa acaaagcccc aagacacacg tagtactagc
63121  attaagtgga agccacctgt gctgctgcct ccactgaaca gcagatgcta ggtatttgac
63181  ttgactgcaa ctgcctctac ctccactcct gcaccgggaa ggcaacctag cagtgacacc
63241  tgcaaaagta gaagctctga gcagagcctc tttccttaca tttctcactt ctaaagcaaa
63301  atctggtgtg gatgtatctg attagtggtg actaggtgac acatttgcat cttagcttca
63361  atagagtcta ggaattttat tctcaacttt taaacttgga ggtgggactt gtaataggtg
63421  aaatttttgc aaatagagaa ataattttca aagtatgatg gacagtcaca gatatggcaa
63481  atgtccacta gagctgctta gaattccatt gtatggatca accacaattg attaaactaa
63541  tatcttagat ggtagacctc taagtgtttt ctagttttct agtctgtgac ttaggcaata
63601  ctgtattaat gaccatatac atgtgtcatt ttgctaatgt aaaatggaat ataaatttct
63661  agcagtggaa ttgctagatc aaaaggtaaa ttgtaattct tgtggatatt gccaaatggt
63721  ttctggatgc tatactgatt ttttgcttcc actagtgatg ttcctgattt tttttttttt
63781  tttttttttt tgcacagagt cttttccttt tttagattcc ttctgagcca gagtggcagg
63841  ctgagtgttc cctgctactg gggtgagttt tgggccttgg gccaagaatg ctgacaaatc
63901  agatctgggc cataacctat gccaatatag actgtattta gcatctggac tggatttggc
63961  ttatagttta ttgtagtcct tctagcccta aattaaatgg catcttgggg tatctaaaag
64021  ataatgttgc ttccaaaatt gatttgcaat gtgggagtag cttacatctt ggattgttat
64081  gtgttcacaa atgcataaag atgttttcaa agaatggttc taaagaatta taataccttt
64141  tctttttaaa aaagcaaaat cttggccggg cRcggtggct cacgcctgta atcccagcac
64201  tttgggaggc cgaggcgggc ggatcacgag gtcaggagat cgagaccatc ccggctaaaa
64261  cggtgaaacc ccgtctctac taaaaataca aaaaaattag ccgggcgtag tggcgggcgc
64321  ctgtagtccc agctacttgg gaggctgagg caggagaatg gcgtgaaccc gggaggcgga
64381  gcttgcagtg agccgagatc ccgccactgc actccagcct gggcgacaga gcgagactcc
64441  gtctcaaaaa aaaaaaaaaa aaaaaaagca aaatcttatt tctagtgtgt gaactattgc
64501  atagattttg ccaatatctg aactatggca tccaattgct ctggttggtt gccatgaaag
64561  tttatagtaa cataggaagc tcctgtttga aagctcctga aaaatttaaa caaatgtata
64621  taaatgggtg aaaaatgggg gctgaggaag aaggtgaata catgtgtttt cttctcatgg
64681  aagtgttcac tattttttat taaatttttt ttagagacag ggtctcacta tgtttctcag
64741  gctggtctcg gactcctggg cccaagtgat cctcttgtct cagccttcca agtagctggg
64801  actacaggca cgggcctcca catctggctg tgtttgcagt ctttaagttg gcatttacct
64861  agtgcagttg attatttcaa gaaaatacac tttctacatg gctactgagg gtatctgaaa
64921  ggatataaag tatagcccag ggaagtagca tgttgttagg caggggttag taactctttc
64981  tggaaagggt cagttggtat tttaggcttt gcaggccaag aaacagaatc aaagatatta
65041  cataggtaat tctataacaa gagaaaaaat aaacttctac aagcttttta ttgacaaaat
65101  tcaaaacata ataactgagg actttttttt ttggtaatac aggtctactc ataagaagaa
65161  cagcattctt actttgggga taacattttg cttaatggga ttcaaagaat agtgttccct
65221  ttcatcaaat cgattgcaaa tgttcatctg taaataccat ttattttctc cttgtgggcc
65281  atagaaaacc aagcagtggg ctggatttga cccatgagcg gtagttttcc aaccactgat
65341  gtaatggaaa gaccatgagc tttggacctg gatgcatgta ggtttgagta ctggctctga
65401  atttgtgacc ttgaacatat cacttaactt tctgaattgg gaaggtttat ttgtgtataa
65461  actgagtgta atgacaccta tctcatggaa aaaatattac ccccatcttt gtgattttgc
65521  attagtattc tagttctgta gatgctgata tgatttagct agacttacct agaaaattag
65581  tatttaactg attttaaagc tgacttttca agggatagaa cactcacatg gtcttaaagt
65641  acaatgtaaa aacatagctt tgcaatgaag agatctggca gtcaccacat taatcaaatg
65701  accaagcttt gcaatcagta ccaatggtgg gatgttctga cattgtgtgc ccctcactgc
65761  tgtgtacctc tcactatatc tcagtatcac ctgtgtggtg ttcttgccag aaacttttga
65821  ctttaatgta atcacaataa aacagacaaa tccaaaacat gggatgttct gaggacaact
65881  ggcctggatt cttaaatgat tcagtgtcat taagaaccaa gggggattgt tctagattag
65941  ggggagacta agggaaaatg agataaaaat gcagtgcatg aacattgact aaatcctgga
66001  tgaggaaaag aaaattcagc tctgtaggca ttttctggat aatcaaggga atgtgaatgt
66061  ggaccatatg ttgtatgtta gtccattttc acgctgctga taaaggcata tccgagactg
66121  ggaagaaaaa gaggtttaat tggacttaca gttccacatg cctggggaag cctcagaatc
66181  atggcaggag gcaaaaggca cttcttacat ggtggtggca ggagaaaaat gaggaagaag
66241  caaaggcaga aacgcctgat aaacccacca gatctcatga gacttgttca ccatcacaag
66301  aatagcatgg gaaagaccga tccccgtgat tcaattacct ccccctaatt gttcaagtcc
66361  ctcccacaca cgtgggaatt ctgggagata caattcaagt tgagatttgg gtgaggacac
66421  agccaaacca tatcatgttg tatgataata ttgtgttaaa gttgatttcc ttgggtgtgg
66481  tgatgatggt gcggtggtgt acgaaaatat ccctgttctt agaaggtgaa tagtaaagta
66541  cttaggggtg gtgtgtcatg aggtgtgtct gtaacccact tttcagatgg tttggcaaaa
66601  tgggagggaa ggagggaggg agagagagaa tgtgtgtgag tttgtgtgta tgtagaatag
66661  gtgattctgt gcattgctgc tcagttctta gcatagcact cagcacattg cttttgatag
66721  ggaggtgccc aaccaaaact tgttaaacta acaagtactt taaggtttta gtaggattct
66781  ctgaaatcac acctcagcac tgcctgtctg ccctctcttt agcagtgtca tttggcttag
66841  gcatatacta taatgcctaa tgttgggtaa tcagatatgg gggttcatgt tttcttgagt
66901  agctcaccca tgtccctctg gactgaaagt ctctcttgaa tgttacagta taaatgaatg
66961  ggaaaggaaa acccagcata gaggttgacc tgcgtgttca gctgttccct gagaggctga
67021  ggtacaattt gtaagcatgt acttcagatt ctcttctgta tttctgttgc tgagtttgcc
67081  cacttgggga gggttgacac ctcctggggc tgtgctgagt aggaggtgca tctctggagt
67141  tctgactggc tggagcatca ctgaggtatt ctcctgggct atgagggcta gggccaggat
67201  aaagaatggt ggatgccttt ccttatgcct tgatcctaac cggtaccctc ttagctgagc
67261  aggaagggaa cagagaaatt aatattctct tatattcctg caggaactct tatggctata
67321  tggtgtgaga tgactaaagc caatttagca gctacttgta aaagtaataa aaatggaggg
67381  gaagaagaaa gattctgatg caacaggctg tgaagactaa ttcaacattt atttattgag
67441  ctactgagca tatagcaggc atagtaaagt atgagtcctg ggggatacaa ataataagaa
67501  tataccctcg ctttctgctg ggcacttagg gcatagggaa aggagatggg ctacagtgga
67561  gataattatc aaaataccaa ttgtgctgtg ttgcaaggct agggatgtgt tagaaagcta
67621  gtaaaaagtg ttatgggaat gcagagaaca tgccatgtgg aattgactac agtttcaaag
67681  ataaggttgg tcttgaggtg acttgaagaa tgagcctggc aggcaaagaa atgggcatct
67741  ggtgtgacta aagtcttaat tagctgtagg gtggggagga gagagacatg acgatgttgg
67801  aaaggtagtt tgggccagac aggagggcct cagaagccat gcttggtttc acaggaaggg
67861  cgtgaagagt cccagaagcc ctttgaagtt ggagggtgat gtggttttga taagaggtca
67921  cggagggaat gtagaagctg gtgtgtgaag gtgtgtgagt ctggagacag gacttgaaac
67981  agtcgaggcg agagcaaaga atctggattt tgctagctgc agcagaggga gagtagaaaa
68041  tggggtgctc ttggagaatt cttccagccc ctcctactag gagtttttac attttcaaat
68101  ctttctaagg aaacctttaa taatacttga gagaagctta tttaaacctt tgaacagttc
68161  tgaaaatgta ttacatttca gccaggaaag aaagtattat ttcaggcaaa ctggaacatg
68221  gttactcagc acagtcgcct aatcttatag aattaggtag gagggaagct atgttagtgg
68281  ccttcaacct tcttccagaa ctttgttcag atttctccca aatggtcggt gaatttttct
68341  gatttgtatc cagcatccca gccatttagt gtacatccgt aagctgtaag gaagttgatt
68401  taatctattt ctttttttca tctcttgcct tccacctgag aaaacactac tccataggtt
68461  cttattctgt attaggaatt tgcacaatgt gtaacctaag atggatccag ctgggagttg
68521  gatccagctg ggagtgttac aggtttggag tttagactaa agaagaggag tggaatcttt
68581  tcattttttt cccctttatt ttgaggaaag cccagtgatt tggattgttt gaaggatcaa
68641  ttatatcaaa tatctccact aattgagtat ctgggataaa cttttttttt caccttattt
68701  tctttagata ccattaagca tttcgaccca caacttacag cttttccatg gagattttaa
68761  acttagaaaa ctttgaacct tgatgaatga aaaaaacctt tcagaactaa cctttttttt
68821  tttttttttg attcagaagt ccatgtgtaa gttccaaagg cttataattc ttttctcttc
68881  cttgaggctt gactatttca gaacgttctt ggtatgtctc ttggaggttt ggtgtacaaa
68941  gagcaaggaa agtaacctat gggcttaact cacttatgtg tatatattct actttggctc
69001  caaagcaatg attctagtgg tgatatggga ccaagggaca gatttcaagg taaataaggc
69061  tgtttactaa tgtcagatta aggtattagt cttcaagtac cataaatgtt ttactagcaa
69121  tttcagttac ctgtagtaaa gagctttcca gttccatgtg gtagttatgg taaaggagca
69181  actgaaagtt aacttgatag tagattaaca ctcactgaaa atatagttgt tattttttca
69241  cataccaagg attacaatgt cttttttttt Ntctattttt aaaatagaga cagggtcttg
69301  ctatgttgcc catagtcttg aactcttggc ctcaagcgat cttccttgag gcctcccaaa
69361  gtgctgaggt tataggcatg agccattgtg cccggcctac aatttcttaa tattaggagt
69421  tattttgcaa gacaactatc tcaatgttgg aactacacta atgttggtgt gtttttttcc
69481  ttgtgtggga tagtctgtat cttaagatgt gtaatgtata tattcacaat aagggctaca
69541  ttataaaatt cagagacatt ttatttttga ggtaggtttc attcacttaa ttgagaattt
69601  gttgactgta tcttgggtgc ctatccttat getaggagat gaatggaagt tgccccctgc
69661  cattgaagag aagacatttt aatgggaggc agagataaac agataattaa ttataatgtg
69721  atacatttgg aaatagtcac aaaaaacttg aatatggaga ttttcaaaag tacaaagaat
69781  aggatattga accctcatga acccactacc aaacttcaac aattactaac tcttggttat
69841  gcttgtttca cccatgtgcc ccacctcctc ccttccccct tttattttga agcaagtcta
69901  agacactgta tcatgtgatg gacattaata gatacttgga tagagtactc tgagaataca
69961  ctgggaaaac atactgtatc gggacaggga aaggagctac agaaaagtaa catttgagtt
70021  caatctaggt ggggaggagg atgttgttcc aggtgatggg atggaaactg acaattatta
70081  caatgtcttg aaaaatgtgt atatacaact tttttgttcc tctgaactga gcacccaaga
70141  tgtaatttcc aagattagga aattgttttg cctgaggact ttataaaaat aattaattca
70201  cttttaattt agataaacta gaataatcca tgagtagtgg taaYgactaa tctgttctct
70261  tttcacccca gtgactttct agactttgaa cattagaatc cactccctga aaaagtcact
70321  ctcctttgta actagagcaa cagctatcct ttgtcacctt tatttttctc tttggaagag
70381  gaggaataat cagtggctca cttctgaaac atcatgaata ggtagaattt agtaatctga
70441  attaaaaacc tccctgtaaa ctgaaggaag aggaaattga ccagtgggca cacagaggtt
70501  ctcaagggac ttttttggtt agccactagg tgaaatcctt gatatttcat catgtacctt
70561  gtctcatttt cctgttgtga aattgggtgt tcagcattgt ttttcttgtc tgttctcaga
70621  tcacagaact gtgtggtgca aagcgggttg gttattttgg tccaacacag ttttacattg
70681  ccctgaaatt aattgctgca gcacaatctg gcctcccggt acggatagag agtattaaat
70741  gtggtgagta tctcacattt gtatgtttta ttgtccatgg cgagtcgctc atttatgaga
70801  accattttta atgagtttaa acttttgtgg aatttctcct tgcttcctcc aactcttctg
70861  caaaataaaa taagaaaact tggcaggtag gtagcttagt ttctttcttt tttaaatggg
70921  gaaaattctg agagtaacct gagattagtt cattttaact gatttgcagt taaaatagat
70981  tttattcttt agcaggaaga gattgggcca ggaattctag agcctgtggc aaataatcac
71041  attgacttta attttccact tgaggtatct ataatgttat tgaaggctct gttagaggag
71101  taacaaggga gtttgagtgg aactatgcct tttctctttc ccatacctgc cagtgctcag
71161  cctttaattc ttagtttcca aagcactgtt ctgatgctag taagtacttg ggtgctacca
71221  aaattttggc agaatgaatt tatcttctta aggttctgat ttaatatttt ctcatcttgc
71281  catccctgcc ctcaacccac tgtatgcttg agcactttct acaatttaaa caaaaagcaa
71341  aacccccaac tattagcagt atttctgctg cctcaggatt ggttttaaaa atctgtatga
71401  aaaaggtgat tattcaaggg gtgtgccaag gtcctctgat aattcagttt gatacagatt
71461  actttcatat gtccatacag gtatgtagga actttttttc tttttctcat tctgagacta
71521  aaaacctctt aactgctcat gcctgtcctg tgaagtctct gatagacata caagtggatt
71581  caggatttat ggtgagccca tggaaacctc gtaggacaat ccaaatggcc gagaagattg
71641  ccatagatgg ctggctgtgg aagaccaagc ccttcacact aaccgtYagc aggtggcagt
71701  catcatgcta atctttatca gggggctagc ttgtgccaga cactttcatt taatcctcat
71761  gacaccctac taaattaggt acttgtgtca gtttgattgc ttaggataag ctgcgataac
71821  aaatgtcaca atctcagtgc ctcaaccaga cagaggttcg ttttccactt tgcagtgggt
71881  cagggtgacc ctccagggca gctgccctct atgtggtgac catgtgatcc tggctgcttt
71941  atcttgtggc acctcccaac acaacacctg ttcccataat cgccacacca gggaaagagt
72001  atctcaccct agcggttaaa tgctttggcc cagacatgac tgaagttatt gctgcccaca
72061  ctgcattggc cagaacttgt cacattaatc tgcttcagtg cagagcaggt gggagaacac
72121  aattctctcc tgtgcctgca aggagaggac aactgcgagt ctctactatg gctgcacact
72181  gcaagtctct actatggtta tggctgcaca ctgcaggtct ctactatggt gctgccgttg
72241  ttcgtatctt acaagtatgg aaatttgaac tttagggagg ttgagtaact tacctaagaa
72301  tataaggtta gtagaatttg gagccaggat ctacttccag tccccatgct cttaatttct
72361  atgcaaaata gccttgtctc aattttttct atttagtaag atgctgacag taatctgtta
72421  tacaatattt tctgaatggg aaaaatattg gacttgaaag gcatctcttg gtatgacaga
72481  attttgttct ttgaaatagg tttcttgatg gagtgtcatt tgacaggcag gcttagtatt
72541  cattgctgca agacacagcg gccatttgct ttgattagtt gaaagttgca tcacactgaa
72601  tttggatttg tggtaggcac tgatagtttt tattccattg taaatgatca ttaagcttta
72661  ttatagtatc ttccaatttt atcttctgga aaagttagag ctgctttatt gtatacagaa
72721  taaacttttg acacttttgt tacttatttt aagttagacc taagtctttt acctgatttg
72781  tgcccagatt gacagtttaa tttcctgagg gcagggagca ggattgttga agttatcact
72841  tgtgtaaagg attaacagtt tatcacaaat ataaggcttt ctcagtttta ttttataaac
72901  ccagttgctg ccttttacct ctgagagttt atatatgtcc agagttaatt ctgaattatc
72961  ttccttcacc actctctact aatccattta aagattgatt aaataaaatt atttgcagtt
73021  agcatatgtt gaataagaat tagggcaaga ttgggccaaa ctttgagctg ccacttagaa
73081  ttttccagtt tgttgcttga aatctattag cttaatgctt gatgacacaa atcttgaagg
73141  ccaaagggat cactctgtga gaacctaatc tgaaaggctg tgctagccct gtcacaccca
73201  gggcatcata cccagggagt tgtggatgga tacccttatg tcatgaataa catgcacctg
73261  tgtgtatgtg cgtgaccctc taatccctag tccttcccat ttcggtaaat gccaccacca
73321  tcctcagctg cacaagccag aaactcagca gccatcctgg attcctcctt ttccctcact
73381  ccttaataga atccatcaaa agtcctagca atgtggctcc aatctcactc cctgttgcct
73441  ctatctcttt gtccctgcta gaccagacaa ccttcatcta cttacctgga caccacaatg
73501  gattgacatc ctagcccctc ctctcttctc tactgtgatc tctcttttcc cactggtttt
73561  ttgtttgttt Nttttttgac agagactcgc tctgtcaccc aggctggagt gcagtggcac
73621  gatcacagct cactgcagcc ttgacttcct gggtgcaagg gatcctccaa cctcagcgcc
73681  ccgagtagct gggactacag gcatgcgcca ccactcccta ctaatcctac taatttttgt
73741  attttttgta gagatggggt tttgccatgt tgcccaggct ggtcttgaac tactgagctc
73801  aagtgattgg cctgcctcag cagcctccca actttttttt tttgagacag ggcctcactc
73861  tgtcacccag gctggagtgc agtggtgtga tcacggcttg ttacagcctc tgcttcccag
73921  gctcaaatga tcttcctgcg tagctgagac tacaggcata catcaccatg cctggctagt
73981  atatatgtct ttttgtagag atgggggtct tgttatgttt cccaggctgg tctcaaactg
74041  ctgagctcaa gtgactctcc tgtgtcagcc tcccaaagtg ctgggattat aggaatgagc
74101  caccataccc agcctctttt cctacttttg aaagtgtgat cttttcaaaa tacacagcag
74161  attattccat cctcatcctt taaaccctcc agtagtctgc ttgttgtact ttgtaaaaca
74221  ttcaaagtcc ctacactgat ctgtaacacc ctacacaatc tagttcttgc ctacttttcc
74281  atcctcatct caaatcttaa acccttgctc actacctgtt ccccagtctc agtggccttc
74341  tagccatttc tgggtgactt ttcctgctgc aggccatatg tccattttat cttgcagtct
74401  tgggttccta gggatctgtt tttcctttct gcttcccctg gttggctcct tcccaacctt
74461  caggattcag agtctgtccc tactatccta cctaaagtag ttctgtcaga ttcattaatt
74521  catgaaggaa ccagcatatg gtaaaactgg ctcaagaaag tatagagagt cagatttatt
74581  tatagtcata gaaagaaagg atgctggaat agaattgcta aattaggtat aaagctaatt
74641  aacgccctac ggggtaatac aagtgcagcc tggctattgt acttttttct aagatgaaag
74701  tatttgcatt gccgtcagac aagaattact tgttagctaa cagttttttc caagttaata
74761  tctacccttt caggattatc aaatgcccaa ccaagagtaa acagtaactc agagcagaag
74821  tccatatccc taggaagtga ggtgatcctt gggtgggcct gctgggtaat gcttctgcag
74881  ggcaatctcc tccccacttt gttctttccc agcatctgtt tcctgatagc acttagcaga
74941  gtttgcaaat attccttaca ggtttcacta ttttttttgt ctgtcttcct cacttgtcca
75001  gtttgtgtaa gggggaggga agaggatctg acaccccttg cattgtgggg cattataggc
75061  actctgtgtg tattggttga atgaatgaat gaagaggtgc atgtctacgc atgaggaggg
75121  tgtcttaatc atctgccact ctttaatcta aaacgattgg aattcagatt ctcctggaac
75181  tccagaggag tttttacaga agtcatctca gtctgcatat catctttctt aggcactgat
75241  tttcaacctt gtcggcactt gagaaccacc tggagagctt taaatataaa ataaaaaaat
75301  acagatgcct gggtccatct ccagaaattc taatttcata tatctgcagt ccggtctgag
75361  catcagaatt tttaacagct ctccaggtga tttttgtatg gagacatgtt taagaataaa
75421  agctgcatca agcattttta agagctttgc ttaaactgtg tgtgtgtgtg tgtgtgtgtg
75481  tgtgtgtgtg tgtgtgtgta gttacagtag ctgcatctga actagggtgc tgtacgacac
75541  agggcacatg atttaagggg gcacttactc tcagggcaag tgccgactct acatttacac
75601  caccctgaga gtgcgtgcct ccttaaatgt tggcactagg tatctctcta gccccaccct
75661  cgtctgagtt ggggttaaac agatggcaaa acagctaggg cagaaggaaa gaaggtgaaa
75721  attaaggact ggtagagaat ttctgatgag gaaatcatgt ggtgaacatt tgccctggga
75781  cctgctgtta cctttctttc cagggtctga agttgagcac gtgtgaggac tgagggaagg
75841  ttaggcagaa cctagagtag ggtttctcat catttttgtg ccaggagccc ctttggcagt
75901  ctgaagcctg tgggcccttt ctcagaatta tgttttaaat gcaacaaaga cataagatta
75961  taatggaaac caattatact gaaataatca ctaaaatagt taaattgtta tataacaaca
76021  tacatgcttc taggcctggc acagtttctc atgcctgtaa tcccagcact ttgggaggcc
76081  gaggtgggcg gatcacttga ggccaggagt tcgggaccag cccggcaaat gtggtgaaac
76141  cttgtctcta ctaagttcga gaccagcctg gccagcatgg tgaaaccttg tctctactaa
76201  aaatacaaaa attagccggg tgtagtggca catgcctgta atccctgcta ctcaggaggc
76261  tgaggcagga gactagctta aacccaggag gtggaggttg cagtgagtcg agattgtgcc
76321  actgcactcc agcctgggca acagagtgag actatatctc aaaaaaaaaa aaaaaaacca
76381  acccccaaaa catatatgct tctttattaa tgcattaaat aaagcatcta acagtgtttg
76441  aaataaccac tactttttca aattagtaat atgcataaac agtacttcaa gatgttggcc
76501  cggcatggtg gctcatgcct gtaatcctag cactttggga ggccgaggag ggtggatcac
76561  gaggtcaaga gattgagacc atcctggcca acatggtgaa accccgtctc tactaaaata
76621  gaaaaaaatt agctgggcgt ggtgacacac acctgtagtc ccagctactc aggaggctga
76681  ggcaggagaa tcacttgaac ccgggaggcg gaggttgcag tgagccaaga tcacgccatt
76741  gcactctagc ctgggcgaca gagcgagatg ccatctcaaa acaacaacaa caacaacaac
76801  aacaacaaca acaaacaaaa ccctaatgtg ataggtgaca aagttaccgg tattgctagt
76861  gataatacag tggcttgttg cctacattca taatggaaag aaatgctaaa tttcagttat
76921  agtagggaaa atgaagttgt aatttttttt tttttcctaa tcaaggtgac agaccccgtg
76981  atttcttttc actagtccct ttgggagcct gtgaactctg atggtgcaat gacatgattc
77041  atgtagtctt tggggctgtg ttccccaaac tggtttatgg tctggttgca gtctggcaca
77101  gtttagaatt aggacaaaag gatgagttat ttataaagct aaatgtattc aaatctaaga
77161  ttgggttttt tttggttcct cttgttaagt gtcctttgtg aaactgctaa tgggtaatag
77221  tttggggtaa aattcttgac gagataaaac attggcaact ttatgttggc tttcttcatt
77281  tctttttttg ttgttgttgg gggagagatt tttcctattt tgtgaaatcc ccaaatttgt
77341  gagccactgt tgtggtcacg attctactgc caagaagata ctgaggcaaa tcattgaatt
77401  ccctttgact cctcccttat ctgcaaaaca gttgttctcc acctaggtga tttcgtccct
77461  ttagggactt tcggcaaggt gaggagacat ttttggttgt cccagctgcg gaaggggact
77521  gcctggcatc tagccggtag aggccaggga tgctgctcaa caccctacac tgcagaggac
77581  aggaccccct cttccaacaa caacaaactt atctaatcta aaatgccagt aatgttgaga
77641  ctgagaaagc cttctgtaaa ataaggatca agacttagga actctaatcc tgctgccttg
77701  cttcctgtgc tctagttagt ttttttgttt ttttaatcat acaagaaagg tagaaggatt
77761  ttgcagcatt gagtcctatt tctgtggctt ttgttttcaa agaagaatta ttttattcaa
77821  ggaaaaataa aagcagttat tctctggttg aattgagggt ggggttccct gtgctttgcc
77881  tatttgacaa accctcccta tctcttaggg ctaggagaga aatcttttga gtgtgacaac
77941  cagtttggta attcatagaa aagacaggat aggaagccca agggtaaaga aagaagccca
78001  ggaggtaagg ttgtagctgg ctctgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
78061  gtgtccacac agtgtctctg tattttgaac actaaatact atgttgggat gtctcattaa
78121  gctaaggtca actcatcctt tctgactgaY gtccaaccca atcccccttt cctttttttt
78181  cctcagtgtt cctttgtcaa tttcctttac cccctctccc agccctgcta cagggacaca
78241  gagctgcttt ggacaaagtt cgcctatgca ggttcactga ctgtacggct ggacatttgt
78301  gttttctagg ggtctgtccc tctaccccat agcgctgtca ttagctctat tgttgctcct
78361  ccccaaaggt tctccccaac cttttgagct gtggattttc accttatttg taaaaatctt
78421  tgttgtggga ttctttgaca atctagtaaa agctctggat cttagcagga aaatacacat
78481  tgacattatg taaaaaatgt tgccttcaat gtcaggggtt tctggacccc tagagctggt
78541  tcatggagcc cagtgaagag cccttcttcc agagaaatgc agtgtatggg atggatatag
78601  aggaggtaag ttggaagatg catagtgggg aaattgaagg ccaaagaggt aaaataaaag
78661  ggatgctgct tgctagcagc agagcccagt ggattgtgga cctcctaact cactcctggg
78721  gttctacccg tggtatggcc aggaaattga acttatccac catcctcctc tgccaaacat
78781  ttacaagatc acccttccca ttgtaacctc caccccgcca tctagcgatt acctacccat
78841  ttcctaattg acaagaggta tttcagatca atgggcagat aggaggataa taggagacta
78901  gatagctttg attactcagg cctgggttga taagactggc ctgatttttt tttttgtttt
78961  gttttttgtt ttcccccaaa gtaacttcag gaaaatgtgt agggatggtt tcactttgga
79021  attatagaac attattgtca taattctttg ttaacgtata agtagctggt ataagtgaat
79081  aggtaacaaa aagcagtggg agagaaggga gccagcagtc aggagtcaag aatttttgtt
79141  acggtcttag ctctgccact gtattgctgc atgactaagg caagtcttgc tctctctttc
79201  ctgggcttat ttcctcacct gcaaaatgca gacatttgag caggttttct ctagattatt
79261  ttctgaaatg ccacagtttc atgctaaatg ttcaaatctg tactagaaag aattttaatg
79321  ttcaggatgg tagtatagcc ttgtggctgg gaatgtaggt cctagcaata ggctacctca
79381  ttatgaatct ttccttcatt accttttatt tgtgtggcct ccggccagtt tcttaatttc
79441  tctgtttcaa atgactccct ggaggaaaag gtataccaat aacacctgcc ttatagactt
79501  gttgtaagca caaaatcagg gaatccctta tcaaacattg tagaaaagca tctacaactt
79561  tgttatttaa tatcgtagcc acttgccatg tgtggctatt gagcacttga agtgtggcag
79621  tgtggctagt gtgactgaga aactgaattt ttcattaaat gatttaaata aaaggtttta
79681  aacagtgtaa aatattttct gttaaatgca accttattga tttagtagga ccacttttca
79741  cttcaaccat caaattctgt aagacaaggg tcaacaacct ttttcttttt ttttcttctt
79801  ttttaaattt tattttatta ttattatact ttaagtttta gggtacatgt gcacaacgtg
79861  caggtttgtt acatatgtat acatgtgcca tgttggtgtg ctgcacccat taactcgtca
79921  tttaacatta ggtatttctc ctaacactat ccctcccccc ttcccccacc ccacaacagt
79981  ccccggtgtg tgatgttccc cttcctgtgt ccatgtgttc tcattgttca Rttcccacct
80041  atgagtgaga acatgcggtg tttggttttt tgtccttgca atagtttgcg gagaatgatg
80101  gtttccagct tcatccatgt ccctacaaag gacatgaact catcattttt tatggctgca
80161  tagtattcca tggtgtatat gtgccacatt ttcttaatcc agtctatcat tgtgggacat
80221  ttgggttggt tccaagtctt tgctattgtg aatagtgccg caataaacac acatgtgcat
80281  gtgtctttat agcagcatga tttataatcc tttgggtata tacccagtaa tgggatggct
80341  gggtcaaatg gtatttctag ttctagatcc ctgaggaatc gccacactga cttccacaat
80401  gattgaacta gtttacagtc ccaccaacag tgtaaaagtg ttcctgtttc tccacatcct
80461  ctccagcatc tgttgtttcc tgactttttg atgatcgcca ttctaactgg tgtgagatgg
80521  tgtctctctg tggttttgat ttgcatttct ctgatggcca gtgatgatga gcattttttc
80581  atgtgttttt tgactgcgta aatgtcttct tttgagaagt gtctgttcat atccttcgcc
80641  cactttaaag ggtcagatag actttgtggg cagtatgatt ttggtcacaa ctactcaacc
80701  ctgttgtagt atgaaagtag ccatggacag catgtaatca gaggatcatg gctgtgtgct
80761  aataaaactt tatttatgaa cactgaaatt tgaattttta atttttttta ttttttattt
80821  ttgagacaga gtctcactct tgtcacccag gctggagtgc tgcagaggca cgatctcagc
80881  tcactgccac ctccaccttc tgtgttcaag ctattctcct gcttcagcct cctgagtagc
80941  tgggactaca ggcctgtgcc accacgcctg gctaattttt gtattttagt agagatgggg
81001  tttcaccatg ttggtcaggc tagtctcaaa ctcctgacct cgaatgatcc acccatcttg
81061  gtctcccaaa gtgctgggat tacaggtgtg agccactatg cctggcctga catttgaatt
81121  taatataatt ttcacatcat gaaatatttt tcttttttct tttttttttt tttttttttt
81181  gcaaatattc aaacattgtg cttgcgggat gtacagaaat aggcagcaga ctggatttgg
81241  ttcttaggta tacacccaag ataaataaat tcatgtccat caaaaaacat ttataagaat
81301  ttcacagcag ctttatttac aatgggccca cactggaaac aacccaaatg tttatcacag
81361  gataatggat taaaattttc aatatattct tttagggtct tgctctgtca cctagactgg
81421  agtgtaatgg tgctgtttca gttcactgta acctccacct tccaagctca agccatcctc
81481  ccacctcagc ctcctgagta gctgggacta taggtgtaca ccaccatgcc tggctaattt
81541  ttgtattttt tgtagagatg gggttttgcc atgttgccca cactggtctc gaacttctga
81601  gctcaagaaa tctacctacc tcggcctccc aaagtgctgg gatcacaggt gtgagctact
81661  gctcctggct caatatattc ttaaaagtgg attgctccat agcaatgaaa aagaatgaac
81721  tatgtgtaca atacattggg tgattatcac agacaaaaag gtcgtaaaaa aagcttgtca
81781  caagaacaaa tactgtatga ttcaatgtat gaagttccat aatggcaaag ataatctgca
81841  agtatagaaa ttagtacaga ggttgctcgg tggaacaaag ggaggggatt actggaaatg
81901  aacatgaagg aaaattctgt atcttaattt gggaatttgg gtgttggtta cagggatata
81961  tatatatata tatgtatttg tcaaaattct tcaagtggaa cacttacaat tccctataaa
82021  tcatcccacc atacagaata ctctttacat aatttaaaaa gaaatcaatt agttgcttac
82081  atttaacatt gtaataataa taaaatacag taaaatacag atttctggcc acaatggctc
82141  acattcccat gtagcaacta tcaactagag ctgtgctgtt tcagtatggt agccagtagc
82201  tgcatgtggc tgttgagcac ataaaatgtg acaagcacaa attgaggtat gcaaggaggg
82261  taaaatatac atgggagttt gaaggcttaa tatgaaaaaa aatgtaaaat atttcattaa
82321  tagtttttaa tgttgattac atgttgaaat gataatattg ggttaaatta gattattaaa
82381  attttgccat taaaaatgtt ttgaaatgga aaatttttaa ttgtgataaa atacaaataa
82441  catttcccat cttaaccatt ttaaatgtat aattcagtaa tgtgtaaata tagtcacatt
82501  gttgggtaac tagtttctag aaccttttca cctcacctta caaaatggaa actctgtatt
82561  cattaaacac cttcccattt tctttttcct acccagatcc tggcaactgc cttttttttt
82621  tttttttttt ttttgagtgc agtgacgtga tcatggctta ctgctacctc tgcctcccag
82681  gctcaagaga ttcttgtgcc tcagcctccc gagtagctgg gattacaggc gcatgcacca
82741  ctacacccag ctaatttttg tatttttagt agagatgggg ttttgtcatg ttggccaggc
82801  tagtcttgaa ctcctggcct caagtgatct gcccacctca gcctcccaaa gtgctgggat
82861  tacaagtgtg agccactgca cctggcctgc ccatctactt tctggttYta tgagtttggc
82921  tactcttgat gcctcatata agtgaaacca cacagtacct gtctttttgt gaccagcttg
82981  tttcacttct ttctttcttt cttttttttt ttttttaatg tggctcacat tcttttttgg
83041  cagataacat tgaaagactg tgaacagctg ctgccatttt gatggaacat gagttctctg
83101  cccagcaccc tccactccat attgtctagc taatgaggct caatgtcact tgccatttat
83161  tattgcattt atgctgttta cattttttct aatggattga ggaaattgag gtattttttt
83221  ttcttttttg agtgacaggg tttcactgtc acccaggctg gagtgcagtg gcatgatgca
83281  gccttgaact ctcagactca agcgatcttc ctgcctcagc ctcctgagta gctgggacta
83341  caggcatatg ccaccatgcc cagctgattt tttattttta tttttttaag agaaggggtc
83401  ttactgtgtt gtccaggctg gtctcaaact gctgggctca agtgatcctc ccacctcggc
83461  ctcccaaagt gctgggatta caggcatgag ccaccactcc cagcctaaag tattcctaat
83521  atatctgtat ctctatcaaa tatggaaaaa caaaggattt ttctctcttg tagagggtca
83581  agtgtttaaa aaggagcagg cataattttc tttgtggaag ggaaaaatag tcatttatgt
83641  ttaatataca aagcatttct gtgttcaaag aatgtaacct aagatgaaac aacaatgaag
83701  caaattgtca tcttggatgg ccactctcat tgtctcctca gaccctctaa acatttagtg
83761  tgaactctta ctttgtttgc tgtgtgtaat tcaattcagt ttgggagaca agattctaac
83821  caatgactac aaatagacct tcttcttgac agacatcatt gtatagcagg tactttattg
83881  attaattttt tcaaagtttc actattaaat tttgtgtatg tgtgactagg aaaaacattc
83941  agttgagtat ggtgactcat gcctgtaatc ccagcacttt aggaggccaa gacgggagga
84001  tcgcttgagc tcaggaattt gagacctgtc tgggcaatat agcaagaccc catctttacg
84061  aaaaataaaa aaagaaatta gccagcatgg tggcaagcac ctggagtccc agctacttgg
84121  gaggctgagg caggaggatc agttgagtct gggagttcaa ggctgcaatg agctatgtta
84181  gtgccactgc acttcagtct gagagacaga ccttgtctca aaaaaacaaa aaccaaaaaa
84241  aacattcaga ctgaaaattt acaaactact tttacctttc actttttaaa agcttgcatc
84301  agtttaaggg aaatggcacc ttcatgaaag ttttccatga taagaatatt attatgtatg
84361  gttatacttc tgttaagtga gagttgcttg gaaccacctg accaaagaaa gtatgagaga
84421  acttcagctg tattttgtct tttgctgttt ggtggctgtc tgggggagag aggtggtttt
84481  ctaggcacat agctctaaag aaatgccata gacagggtgg aagaatgtgt gaagtgacaa
84541  tgtcctagac aatatctggg agccctactt aagtcctaat ataataattg atattcataa
84601  ttcagttagt gtattccatt gttccttgga ggtatctgtt gaatgccagt aaggcactgg
84661  tcagggagct tataaatact gagcatttat ttcttttctc cctcaagaag tacttggaag
84721  tagagtcatc ctcttatggg tagatcaggg tgcaaattat tttatgtgat cttgtttcat
84781  ctttttagat cctttttcct gactgagctg gagcacatac ctgagaccaa aaccatagag
84841  ttagcttata tttgatttac taagaatcta gagtttcttt tctcttgctt ttttgctttt
84901  gaagcccatt cctgctttga gtgctggaga gctgcccgag attgggaaac attaagattg
84961  gttactctat ttatgtctct tgggcccttg gctgattgat cacacaggga tttgtcatat
85021  tgcctgcttc tttttttttt ttctggtaca gaattttgct cttgttgccc aggctggagt
85081  gcaatggcat gatcttggct cactgcaacc tccgcctcct gggtttaagc aattctcctg
85141  cctcagcctc ctgagtagct gggattacag gcgcctgacg ccacgcctgg ctaatttttg
85201  gtatttttgt gtagagaYgg ggttttacca tgttggccag gttagtttcg aactcctgac
85261  ctcaggagRt ccacccgcct ccgcctccca aagtgctgga attataggcg taagtgagcc
85321  actgcgcccg gccgcctgct gctttgaatc aaatgtgaac atagcaacta aaagtaaaca
85381  tcatgtggat gttagagaac caggggcctt ctttgcctgg ggaactctag gatacttgct
85441  tgctgttgct aagatgtttt ctggccttag cacagcatca gtcattgaaa gtgcagctgt
85501  gtttttggaa tagagagctg atggaagtgc aaaggcacac tgatgagtat tatcctgaac
85561  aatggataca gatgcaaatc attatgcata atccataatg tccccatttt tgtagggttt
85621  tgtgctacgt gattgtgtgt gatttgatgt gctgagaact agaagtgtgc caaagtatca
85681  tttccgcttt cagaatagtt ttgttagaat tttgaaagat gagtaaatat accagaccgt
85741  tgcttttcaa ctctttgtag cattttgagt ggctaatggt tttgacagaa gaatgtggct
85801  gaatgataga ttgattgctc tgacttgata ttgttttcct tattccatta tgaaaagaca
85861  accagagatt ggatgtgaaa attccttaaa gaattacata ggatgagaaa ctgttctacc
85921  cactaagttt gccataggaa caagggacca ttctgtagag cactggtaaa gtaccagctt
85981  gcctgcattc aaaccgtggc tctgccacag atgagttgtg tgatcctggg gacattactt
86041  agctccttta tgactgtttc tacttttgca atgagggggt ggtaatgata gttttatcat
86101  acagagttgt tgtgaggatt aaatgagtta atatttgcaa atctttaata ctgtgcctgg
86161  catatttaag cattatatga attttacctg ccaccatttg tcacttatta ttgtattata
86221  cagtgtcata tcctttttct tggttattga aggatgaaat gggagatcag tcccaaatct
86281  gaatttattc tgcgatttgg caacattgaa aaatgttaag ccagaatact ttggttaaac
86341  catagcattt taaaaatcag gacgttatta taggagtact cattgtatct aaatctaaat
86401  ttatatttag tgctctggaa tttttcctca aaaatgattc atcgtttggc cattgagttc
86461  cccttttttg cagtttttaa attaagtctg actagagctt ctctgatttc tggtcccaaa
86521  gaattgcctc tgcctcgctt tatgatgtca aagaatgatg gtgagatacg atttgggaac
86581  ccagctgagc tgcatggaac taaggttcag attccatatt taactacaga aaaaaattcc
86641  ttcaaaagaa tggacgatga ggataaacag gtaaacagtt tgttcagatg tgttcatttg
86701  attctgacca tgaaaccgca tgtagcaggg cctcgtatct actgttcagc ttccagcaaa
86761  tctcaccatc tggaacccaa ttacagactt ggaagtgagc cagtaaagtt ttctcctagc
86821  aagaaagaga gaccgacaca tatgaatcac caccacccac ttaagggccc tttagagcct
86881  actttaaagt agaattgtgt ctaaaataag gctaccgatt taatacattt attgatttca
86941  ctagctcagt ggttttctaa atggattctt ggaaatgtaa cttccaggag tttttaatag
87001  gttctcttct ccaaaaagaa gtctgtagaa aaggtttctc ctattataat aaatgtgttt
87061  ggagaatgct gcttcatatt cccttgttga gggaaggact aaatcctcag tcttggaaat
87121  tcgtagtgca cattagcacg gtaaaagccc tgagaagttc tgcagtgaag agacctggaa
87181  atgtgtgttt actaaacttc tttcaccagg aaattctttc ttggggaaca tatttggaat
87241  actatcttgg gaaatgctgc cattacccat ttagcaggtt tggaaccaga acagggagga
87301  taggctttta aaattagacc actaattgca atggtcagat gatgattggt ggagacaaca
87361  gtataaaatc tcagaagagt gggcagatcc agaagaagta aatagtctac acattRgtgt
87421  accctgcagg catcaaggta tagctcatac ttccagcaaa gatactgaat catgcagaga
87481  agtcaaatta tgttcaacat agtgtcttct ataaggtaaa gaaatttatt ataggaacac
87541  ttgaggctgg gcacggtggc tcacgcctgt aatcccagca ctttgggagg ccaaggcggg
87601  tggatcacaa gaggtcagga gttcaagagc agcctggcca acatggcaaa accctgtctc
87661  tactagaaat acaaaaatta gccgggcgtg gtggcatgtg cctgtagtcc cagctacttg
87721  gaaggctgag gcaggagaat ggcttgaatc cgggaggcgg agattgcagt gagccgagat
87781  cacatcactg cactccagcc tgggccacag agcaagactg tgtctcaaaa aaaaaaaaaa
87841  aggaacactc gaatgaaaat gtttttaaaa tgcaatgaat attaaatgat tatgttggaa
87901  aactaacttc tgtgacttac cctgtgatgt tgtgtagatg aggtgttgct acagaagttt
87961  tatatggata gttaggggag gtgtagcaca tcctgttaaa caattccatg tactgtcact
88021  ttcataattc tgacacattt taaatcagtt cttcagggat atatttaaaa aggaagaggt
88081  ataggaattt tcagtcaata ttctttggca tattttccca ccagcatttg gagaggaatg
88141  agggtccact gtcccacggt ggttgatgcc ctgggaaatt tccaggccca gtccctgatt
88201  gtgtgaatga gaatacatcc tttcacttca ggctgagttt atgcatgccc cacccaatct
88261  atgggtgtga gctcatgctt tagagcaaac atattttgct ttttcttgaa gaagagtatt
88321  tgatcagtat ttcagattac atatttctct ttagactaag ggagcctata tatatagtct
88381  gtgtgttgat agaaagcatt gttttggctg ggtgtagtgg ctcatgcctg taatcccagc
88441  agttggggag gccgaagcag gaggattgct tgagcccaag aattcaagac cagcctgggc
88501  aacatagcaa gacctcattt caaaaaaaaa aaaaaaaaat tagctgtgtg tggtggcgca
88561  tgcctgtagt agctactggg ggtgctgagg tgggaggatt gcttgagccc aggaagtcaa
88621  ggctgcagtg agctatgatc acgccactgt gccccagcct gggtgacaga gcgagaccct
88681  gtctcaaaca aacaaacaaa caaaaaaaag cactgttttc ttggtacttg aatactccaa
88741  agttaccagt ctactagtaa agtttttttt tttttttttt ttttttaaag aggaaactca
88801  gcagcagata aggttgctta ctttgcctag ggttctacat caggttcata tttgaattga
88861  gattcaaatt gtagcttgtt aagatttcat cttagtgttt gggagtaagc tggttggaat
88921  ggtttaccta taatgaattg ttttgcagtc tctcattgtt aaaaaaaaaa agctagcatt
88981  ttactttgac atggtaagct ccaagaatat taagtattaa gcatttagaa atatatattt
89041  taatattcac atttgctgga agacttgata agtataaatc caggaaataa atttattaat
89101  gaatgaaaat gaaatctatc cacagagaga tcacaattgg gagcgggtat gaatgttatt
89161  tcatgtgatc agtgtctttc attttccaaa ggaaaatatt attggaataa ccaaaagtgt
89221  ttcaggctgg ttttagtaat ttaggtaact cagcactgat gagattttat tctctgggag
89281  acttYttgaa tcctcagaca ctgctgttta accatgctgc atttttgaga aaacatttcc
89341  ccccatttgt taaaccagct gggtcaccag cagtagagtt gcgttatgct tcctgactgc
89401  agctcagaac gccaggcttg agtgagcgcc tctgaactct gatctggttc tttgaagcag
89461  gaaacacagt ctcccacgat gtcacccctc gcctcccctc cttcttcccc gcctcattac
89521  cagagggtgc ccttgagcca tggctacagc aaactgcgga gcagcgcaga acagatgcat
89581  ccaggtaaga ggcgacctgg gggccagctg tcccaggcag tgtcttagag actccttaat
89641  ttaYcaggcg gtaacgcttc aagctgctta atttcctgat ttaattaccc ctgtctttgg
89701  aaacatggct caatttaatt ttatattctc aagcaaggtt tttttttaaa aattgattta
89761  aacatatttg agtaatgttt catctcctgt cctagaaact agttcgtctt tagacttgta
89821  aacagctaga tgatttaatc tttcatatac agattttatt gaatagaaca taccatatta
89881  agggcttgta ttttttttgg aattgttatt cctttctgta agcacaccaa agatatttat
89941  atagtaactg ctttaatgaa atttcttaag aaatataact gcaaaagcaa aagagttgat
90001  ccaacctttg aagactgagc acgtaaatga aaatatatag gtcctgtgct ttggaataag
90061  gataaaggaa atgctagggg tagcattttg ctgaggggta tgtagcatgc acagttgtgg
90121  ggttgccttc ttgctcacat ttatgctctg ctggcctcgt taggtggtaa aatacgttag
90181  ttctgaggat gacttgcaga gttggctgtt taggctgcag tgcctaaagc actggaaatt
90241  cactgcagca tcttgtgcct cctggggttc agactcctag tttaagatat gaccaattaa
90301  aggtattcta gaactggata tctgtaaacc cccacccccc cagttttgtt ttgtgggctg
90361  tggccccaaa tgacccagtt tctgcaggtt tttactgcat taaaaatagt ggtgactttt
90421  agagggacac agaaataaaa ctgcgcgcta ggctgaataa agagaggctg taatcttgca
90481  gagagaagca ggcgtggcat aatggcaata gcttttgatt ggaagcagaa ggtgtgtggg
90541  tttctgtgac tagctgtagg actttgggca ggccattgaa catctctgaa ccacgattac
90601  ctcttctctc ttaaaatgga gtaacagtat cctagagggg tattagaaga ttaagtgaga
90661  atgtgagtat aaaatctgtt tggaaattaa gtcctatgca catgcaagat gatgttgcta
90721  atggatagta acaaaaaaat cactgtcctg taacttgaat atctcagtgg ggttagaaac
90781  taaatggagt tgagaattct tcattttcct cttatagttt ccctgatctg atttccctat
90841  tttcaggagt gggttttttt tttttttttc ctatttctaa tcttacttgg gtttggaagt
90901  tggtttttaa ttcacaggtg aaactttttg ttctactgag tcagcctgtc agcaagttct
90961  acctttggta ttccttagaa aacttttctg ttcctcctcc ttaatgcccc attccctcct
91021  cattccatac aaattgggct tccatttccc cagtggtaag gaagcagctt gcttctctcc
91081  atctttcttg actctcagca gcctgtgcca aagctgtcca tgccttcatt tcttttcata
91141  cttttttaaa agtgaggtaa aatatacata tgataaaatg tacccgtttt atttgttcat
91201  ttttgagaca ggttctcact ttgtcactca ggctggagtg cactggcgcg atcatggctc
91261  actgtagcct tgatctccta ggtttaggtg atcctcccac ctcagcctcc tgagttggtg
91321  ggattacaga catgtgccac cacaccgggc taattttctt tttgtatttt tttgtagaga
91381  tgggatttcg ccatgttgcc caggctggtc tcgaacccct ggactcaagc gatccgctct
91441  ccttgtcctc ccaaagtact gggattacag gtgtgagcca caatgcctgg ccatgcacat
91501  gttttaaatc ttcaatttga gttttagcaa atggataggc ccttgtagct accactttga
91561  tcagtaattg aacatatcca ttatgccaga gatgaccctc tccggtcact ccctgccccc
91621  taacgcaatc actgttctga ttttcatcac catcattagt tttgcttctt ctagaacttc
91681  atatgaatga aaacacacag aatgactgac tgtactcata tgtgtttgcc atctttcctt
91741  cagcataatg gttgaaattt atctgtattg ttgtatcagt agttcattcc tttttattat
91801  ttagtagtgg gatatattgt gtgaatgcat cacagttcga cgatctgttc tcctggtgct
91861  ggacatttga gttgtttcca gtgtttggct attatgaata aggatactat gaacattcat
91921  gtatgagtcc ttctgtgaca tatgctgtca tttccctggc tcctaggaat agagtcactc
91981  agttttaggg tagttgtata tgaaactgcc aaagagttct ggtttgacac tgaacttcag
92041  agtgatgaaa tctttaggtt tttttttttt tttttttttt tgtacacctc cccttggaga
92101  aagatggtac ttccagttct tattaaacct cttgtaaggg gatcaaagaa ttatttgttt
92161  tgcactgtat tgcatgtttg gggtttcatt tgggaagaaa gagagttgag taatagctac
92221  tttttaacct tctgaattca gatccaatta aggaaggagc cagaagtcag acaattgatg
92281  gcctgaatat cagctttatt actgatatag ctgatcagag cacatgtctt agatttgtga
92341  ccagatgggc tttagacact cacctttcca gtcacaggca ggcttggcca tcccagattt
92401  cccacacaag taggaagaga aaatctgcct ctccaaaaaa ggccccccat gcagctgagt
92461  cttcatccaa gccctactga tgagataggt ctgtctcttc caagggaagg cccttgtagg
92521  tgagggatag aagccaaggg ccagatggtg gcctgttccc ccatgtgtct cccctggaag
92581  tagaagtaga agctcttatg ggaagcagag gcacgtggga ttcacttcct aaggaaagct
92641  catgacYgct agcaccccaa ccatgccaca gttcactgtg tttcaaacct tttggcagag
92701  cgcaattggt attagtgatt taattcagtg ctccatcaac acagaatgat tttaaaaatc
92761  ctacttctca gaagacaatg gtggcctacc agctgagact tactttttaa aatttggatt
92821  atgtgctctc tatgtatgta tgttttgcag tttttatatc tgtattcatt cttagcaggt
92881  tctgaaaatc tacttgatgg gttgccaggc aattgttttg ctattttaat gtgtgttaat
92941  gtattgtaac attgtgttcc agttactagg aagaaataca aaaagcagat gtgagcccaa
93001  gagtgattta tcattcttga tgtgctattg ttgtaccttc tttattttaa aaagagcaaa
93061  ctatgttaaa catgaggtca taacaggctg ctctgctctc tacctaattt tatttgtaag
93121  taagctacag aaataaaaca ttttacttat ttatatattt tcaaaaactt gaactattaa
93181  cctatagaga tgagaaagaa tttcaacttg ggtgataatt tctgctttct gttggagctg
93241  catactacct ggttatgttt aactgtctcc ctgccatatt ggtaaggtca ttattaagtc
93301  ttctggaaat aaaaggagtg aaaacataca ttcatttttg tggcttaaaa agttatttta
93361  aaggcagcaa aattgttttt taaaagtttg gttattgaat agtagaataa taaatataaa
93421  atatatttat tcattttcgt agtcttctct acatgatttt acattctgtt tgatttattt
93481  ttcaaaaata atgttggttc ttagtgttca aaatgcacat tagttttctt cttggggaag
93541  tggatgatca atggaagaca tttacttagg ggggatatat agaatttacc tcatatttag
93601  aatttgaaca cttatgacac ttttctagct attgttgctt tctatcccaa ttgaagttct
93661  cactgttcca ccttcacaat ttattcctaa tcataaccca gtgtaaatat ttttctgctt
93721  atcatgaatt ggttgaatgt ctttagattg tttagtgaaa ttgtgccaaa gagaatcagg
93781  ggttgtcagt cctagatggc cctatgagta ttctgttgcc agttctttcc tgaaaagcag
93841  atgctgtatc agtttgaatg tgaagtcata atttttgaat ggaatctttg cataccatac
93901  tgactttcct ttctgctgtt tcagcacctt atgaagctag gcagcccctt gtccagcccg
93961  agggatcctc atcagggggc ccaggaacca agccccttcg gcatcaggct tcccttatcc
94021  gggtaagtga tgatgcaggg ttatgccaat gggacagtag agtcaagctt tgggcttcgg
94081  ggacatggct ttttgatgga ccctttttca ttgcaaggaa gatataaaac tgatccttca
94141  tgcaaatatt gcatgtcttg tttggttgct tgtataaatt actaaatctt ttctactgtg
94201  tatgtctcta cgccttctca gtgtctctag aataaactag gctgcttctt gatctttagt
94261  atatctaaaa tgtccctctg ccttcaccta tctaatcatt agccaccact ttcaggagag
94321  cttcactttt tctaaagcag cccatcttgt ctctgcctta ttctttatta ttactcattt
94381  aatgcatagt taactgtttt ccatttgttt tgtgcctcta attacatggt aaacttttgg
94441  aaggcagaag tagttctgta ttctctctca gtgcctagac caagagaaca gttattgtac
94501  aatggcagca gctgctgttt ccttatgtaa taaatacaaa agaaatatta tggcaaaagc
94561  ttctggctat accacagctt agacaatttc agcttccctt tctgcagtgt tttcctttgg
94621  ataaagagct cttattttgt tctctgtctg cagctgttgc cttgtgtagt gtctctgggt
94681  cctgtgctgg ggaagttata ttctcaaaga agggtgtgtg tgtgtgtgtg tgtgtgtgtg
94741  tgcacgcgcg ggtgtgcagg tttactattt gacactaaag aggaagtggg gcagtttgta
94801  taacatttca gtcatctaac tcgggaataa ggaacatttt tgcacaggca cttctactca
94861  gaatagaagg gtggtgtcag acactcccat aaagatgtgg gctgctaggt tggaatagga
94921  taaacaaagt ctaaagaagg tcctggggtt catggaatac cttctgggga tggggcactg
94981  tgttagatgt ggtgcagaac ttgattttct aaggtgggac tctgtgtaca aataatttct
95041  taaagataat aatttagcca taggctattt tttatattta atgcttccta caaccataag
95101  atctagttac tgctgcttct aatagtataa gtgagttgac tgtggttgag agaggtcaaa
95161  tagctggttt aaggtttcat tcataactag tcagtgacag agccagaatt tgaatccagg
95221  cctgtccaat gtcaaaacct gctcctttca ttactttgtc ctacattaga gtcccatatt
95281  acaagaaggc taggttctag agttgctaca taaagaaacg ttgggtgtag taaaaaatac
95341  tcttgaaaaa tcccttattg ataccacact ggagaaccaa tatgccattt gctcccaggg
95401  ccagtacagc tcagttttat ccccaagttg gaaaacacat ttgtttcttc agctgagctc
95461  cagatgtagt agttggctgt gtttagagat cctgtggtac aaaaatatgt gcctttaaac
95521  acgagaatca cacccactgt ggagtgaggt ttacgttaga aaaggtatca gtaggactgg
95581  gatttatccc taagctctcc aaaatgtggc tgtgtaggtt cctacagagt gtgtcctggg
95641  aatacagagg ccagatcctg aatggttagg atgatagtca aactaccagt gcatactgag
95701  ctttacagca gtgtgactgg gctcactaga ccctttctac ctagcccctg gctggcatgg
95761  gcatggatgc tcatttggat tggcaccctg tggcttctct tctaatctcc atgttccctt
95821  ttctgctgac aaacatgctt catgagccct tcactcaact aatatttagt gaacacctat
95881  taagtgccag gcactgtgtt gagaatacaa aaatgaggta taacactaac agtttctgcc
95941  ctcatggagc tactggagag atggtcatta accaaaccac cacaaagtaa atgtataatt
96001  atgatatggg atatcagtag gaattacact gtactttaag gatgaaaatg ggcatggggt
96061  atgacctagc cttgaggggc aggggctgat caaagaaggc ttctggtggg ggagcaacat
96121  tcgagttgga ataagggtac atgggtgtta tccaggtgac agggtgggag tgcgggagca
96181  aggtgacaag atggagggaa ccgcatatac aaagacattt cctatgggtt tgccatttta
96241  tgaacattat ctctttcagt gcccacagct atcttatgaa ataattagtg ttgttatccc
96301  attttcagat gtcagaacct gaggtttaga gaccttattt aatttgccca agttcacagc
96361  taggaagtgg cagggctgga gttcaaacac tggtcaaggt tcctcagtct ctggctcagg
96421  aaccagatag atggtggtgt cacctgttga gctaggaagc cctagatgaa atactggcac
96481  tggggaaaga tcacaggttc agtgtttgat gtcaggaact gaggttttga gatagtccag
96541  agaagctgtt gaagaactgg tagattacat gggtctggag cttgggagag agcttaggct
96601  ggacataggt atttggcagc aattggctat cagaaggtct catggtatag tgcagaaaaa
96661  accagacagg tgctcgccca agtccagcaa aactctgtgt gaccttgggc aagttccttc
96721  tcttttctgt aatacaaatg acttcgaatg gatttaacag cccattgtaa caatcagcaa
96781  cagtccgatt ctcttaatgt gtctgtggtt ttcatggctg gtgtgttttt ctttcctctg
96841  ttcttaggtt tccttcttat gcctgttaac ttggtttggc tggactccgt gttccagaaa
96901  gcaaaatgcc aacctggatt agtcatgtag atgaggggat ttgaagtgaa ggttcttggt
96961  gataagggat taatgtttac tgggcatggt gctaggccta ggctggggtg actaatcccc
97021  ctcatgttgt cacgttgatg tgccgatggc aaccttcttt ctcttctaac tagttctctg
97081  gccttgtatt caagttcttc ctgcctgatt acaagggggc atgtcctctg ggtcctgggg
97141  gaagccttta gggactccca gccagtgctg ttgcaaccca tggtgttggc attttagagg
97201  tgcttatgcc aatccagtgc ctaaacattg gaatgatttg tctttttgct tactatttta
97261  ggaatttcac ttttgttcgg gtgttggatt tttttccctt tgaaatttca gacactaagc
97321  atatcctatg ttggtagatg attgatagtg ctttgtaaag aaattataag acttattttc
97381  tgcttcatct gttatcatat gtttagatgt tgttttgtgg tttgtttttc acaaattacc
97441  ctcaacatct agatgatgta gtcatttgta attttgctgg caaaagattt agaattgcac
97501  gctttattcc tactgttctc agctgcctct gtttttgcca gggtcatgag aaactttatg
97561  ttaagccgtt gtctttattg tctccttggc agctgtggac actgaccatc ttctcgaaat
97621  gctctcatca tttggtgtcc attatgcctg ctctcctggt tttcctcatg cttctatggc
97681  tgcccctgcc tcatttgttt caatcctcct tcctctgccc tccccttgtt atgctggaga
97741  ctgctgggcc tacttctcac tctacttact ctttagatgt gtggatgctc atgaccacat
97801  agcaccatct gccagacatc ttcactctaa tgttccactg tcactttcag ctgacatgtc
97861  tttctcataa aatcagcttt cactcttcca ctcctagctc cacccaccca tcagcacagg
97921  ccagaatgct ggtcattgtc tttgacttct ctttctctcc ttatgcctgt tcagtcccca
97981  agtcctgacc ataccacttt tcaaatagct tgtgtctgtc catgcctctg tacttcttcg
98041  ttcaggccat tatccttttc actgattgta ttgtattagc ctctctcttg tttcttcttg
98101  cttccaccct tgccttcttc caattcatta ttctcattgc acacaaaaac aatcttaaaa
98161  acacaaatct aatcatcctg ctgacttgat tgaagcctgt ccctctctgc ccatggctct
98221  taacatgtca tccatgttgc tgtctggccc tcgcctacct cctcggccac agcagctcac
98281  tgccgctttc cctccactct ctggccattt cccggatggt cagtgttctc tgcgtgggag
98341  ccttactctt caccctcact tttgccttct ttgttttctc ctttgtctca attcatctat
98401  gcttttttcc ccattaagaa cgtgaaacgt aagtgttttc tgatattttc ttgtatatgc
98461  gatgtttcct ttttttttca ttcttaaaaa gaaaaagatc tattgcttgt cagctcattt
98521  atgtgtgcaa ctcagccaga gggatgggcg tctgatcatt attggtttcc catctcagag
98581  gcaaccaggg ttgcctgttt cttttgtatc attctaggaa cattttacgc atgtacatgc
98641  aaatataggt attcatatat attaatatgt gtgtgtatgc actatatgta tttatatatt
98701  tatttatttt tttagacgga gttttgctct tgttgcccag gctggagtac aatggcacca
98761  tcttggctca ctgcaacctc cacctcctgg gtccaagcga ttctcctgcc tcagcctccc
98821  gagtagctgg gattacagge attctccacc atgcccagct aattttgtat ttttattaga
98881  gacggggttt ctccatgttg gtcaggctgg tcttgaactc ctgacctcag gtgatctgcc
98941  cgcctcggac tcccaaagtg gtgcaatata tttttacctg aatttaggga gacatgtttg
99001  gcaaatgaat atattcttcc agctagattg cactagaaaa aattatcttt tatttaaaac
99061  caaaacacat tcacttttca aaccctcagg atactgttgt gatgttttct ttgctttttg
99121  gagggatgaa agtaacagtt ttctagaaca tattctcaac actcactact cttcttcaga
99181  gatgaaaaaa tgacaaacag aatttagata cctctattac tctaccattc ctcagggggc
99241  ttagctatat ttttggtgta agttttctaa tgatcaggta ggggagggga tgttaggcat
99301  tgttagccag caccatattc atctcgaagt gcataacttg aaaaatgttt atttaactta
99361  gttatctcct ttcctcctca tctcagtttc ttgccgtacc tcctccccta gatataactg
99421  caggtactta cggccagaag caggtgatct ccactccttg ggtcctcttg gaacccaaga
99481  gaaaaggcaa gtatatgaaa gatgattaaa gaaatgaata ttcctgaggc tctgtcagag
99541  tggtgttggc ctgagtcaaa agataattga tagtcaccac aaataaattg ttcattctaa
99601  gagctttgat gaaaacagca ggaaatagcc tttgggggag gctgatattg caccgagaga
99661  tcttcttgtg gcatgaaaga tattttatgg gtagactgga ccaggatgca agcaggataa
99721  ggagagcgga ggagtgagaa tgactgatgg tttgggatgg gattgagtga ggtgggttag
99781  agttgagtca tgagagagtt ggtcatctga gtttggaaga agagtgaagc aggtaaacaa
99841  gcggggcata ctgggtactg tcttggctac tctggttgtc taacctaata ctcagcccag
99901  ggaattgacc cacagagcag gtcaggcccg cccggattct tttggggttc aagaattatt
99961  taccaaggca ttacttggta agtaagtgtt catacgaacg tgtgtgagct ctcaaacaca
100021 cttgttcttc agagcaaata cagattttaa aaatatgtca aacattcaac agatacaaaa
100081 gggcacagtg aaaactgtcc ctaccatttc cccgcacagc cactcatccc aggggcaact
100141 gatatgaccc atttattttg tatagtacta tacaaaacat ttatataata ttgtatatga
100201 atatcttttt tatatacaag tgaaaatagg tattatatat aattacatgt aatatatgca
100261 aaacacagtt atgctttttt acacatatgg tggcatacta tacatctaac atgcatttag
100321 cactaacaat aagctttatt aacgttctat agcagcacat aaagtacttc ctcatctttt
100381 tgttttttac agatgcatag tatttccttg tctgcgtctt gtgtaaatca tttagccagc
100441 cccttttgat tgacatcttg tacttgcaat cactgcgttg tttgcagata tatgggagac
100501 caattcctag aaattgaatt attgggtgaa aatgcctata tatttgtaat ttttgataac
100561 gactttcaaa ttggaggtat agcagcctat gtacttgcca acaatatatg aaaatgtctg
100621 ttttctcgta cctttgtgaa aacaatgtgc taacaaattt atgggtcttt gccaatctga
100681 taggtgaaaa atgatagctc actgtagttt aattagcata tctctttatt agtgaagtga
100741 aatatcttaa gtttatgagt cacttgtatt tccttttctg tgaactgttg attcatatca
100801 agtgcccctt tttcttttga gtattggttt gtcattctta atggcatgaa accagaagct
100861 ggtctgtctt ttcctttgga ccagagatat actggagtgt gtgtggaaga tttctccctg
100921 agtggtgaga ggagatgctg gcacctgagg ctctcgaagg aggttatgga ccccagctgc
100981 ttcccagttc tggagaaccc caggcctgcc tgcagtgcag atttcttgtt tataaggtca
101041 tgacagtaaa gttgaattac ttagtttatg ggtagagatt agggctaaaa aaaaatcctc
101101 tgttgttaga gatggtaaat gtcaacactg tgtgtgtgcg ttgatctctc agcattgctt
101161 agacagctaa attatgttcc tttcactgaa atgggtggga ggaggagata gaggtagaga
101221 taaagataga tagagggaga gagtataagt gtgtgtgtgt gtgtgtgtta ggaagagtga
101281 gtttgatgcc ttttctaggt atgtatgtgc cttattcttg agatcttctt tcaccaaatt
101341 cattcctcgt ttcatttgag accccagctg gacgtttata ccatctccta aggggtcaaa
101401 ggttaacatg tcctccaggt gtcctacttc actgagtcta ctatagaacc cacatatacc
101461 tgaacggaca ctattgccac aaggaggtcc tattttttca tagcctccag tctcctgctt
101521 acttattttc ttcacctgct tgtagttctc tttctgattt tctagccctt aacttttgag
101581 gaaggatttc tagctcttaa cttttgggga aggaaacatt taatctcaac tgatactgaa
101641 gtttattttc tcagtgccaa tcttttctac ttgtttcttt tttctttttt ccttttcttt
101701 tcattgattg attgattgat tgattgagat ggagtctcgc tctgttgccc aggctggagt
101761 gcagtggcgc gatcttggct gactacaacc tctgcctccc aggctccagc aattctcctg
101821 cctcagcttc ctgagtagct gggactacag gcgtgcgcca ctgcgcctgg ctattttttg
101881 tatatatttc ttttagtaga gacggggttt caccatgttg gccagggtgg tcttgaactc
101941 ctgacctcaa gtgattcacc cgccttggcc tcccaaagta ctaggattac aggcgtgagc
102001 caccatgccc ggcctctacc tgtttcttag tgtattcctc aggtgctcac tgtgtaccac
102061 acttcttgac aataaaagag atgtttagtt aatttagcct cccagaggta gctgaaaaca
102121 ctggtttgaa ctgctggttc caggcagtac tttgtaaatc tggaaaggat agtagcttat
102181 tccccaggac cttttggtct cagttatatg ccaggctatg gatatggaag acttctttac
102241 aactggcacc attttagccc ctgggcccat cagtctttcc cttgatctca ggcRagcagg
102301 gagtgtcatg cccccccagt tgcctatccc aacaatagtc actactgact gaggtgcttc
102361 tttggtccca gtgctgtgct ggcccttttc agtcctccca acaatctcac aaggtaggta
102421 ttattacatc ttccatttgt ccatttggaa atacttaagt ggcttccatg agtcagccac
102481 catgccaggg gtacactgag gagtacacct atagcctctt gctctctagg tgcttgcagt
102541 caaaaggagg agatagattt gaatcaaatg atcccaccta tgcatgtgga attaaaaact
102601 gacaattgcc ctaaaggcct taaaacatgg taccatgtag caaaggaatc cagcctatag
102661 ctagaaagtg agagaaggct cctttaacaa agtatgtgtt gagctgagct gtgaaggatg
102721 aatagaagtt aaccaggcta aggaaggatg gtcctgggag gtgaggagag gagtggagtg
102781 tttcctgtag aggtaagagc ctctccaaaa ccgcacagca gagctgggct gctgagagag
102841 ctttgcttct gtcacaatca gaaagctaca gcattgggaa actgctgccc tagtgtcagc
102901 tccaaccaga tccacactac aaactacctt ggcagccaaa tgaaagcttt gttccctgcc
102961 tgtaacttgg gtctgcatcc gtcttccgtg ggtgtatttg ttgagtggaa cctaagtcct
103021 atttggaatt ctagcagcaa aggtgttttg acagtggagt ttttagctag Ycagcttgtg
103081 cagtgctggg acttatgctg acgggtggaa tggactcgtg acccagtctc taccatattt
103141 cacagggaga gcagatacat ttgaagaact gaaagaaggc agctgtggct agagcctgga
103201 gtgggaggga gatgaggtcg gagagggagg cagggccctg tgggctatgt gactgccttg
103261 caggtgggag ctgatggctc agaagttaat ttactggtta gtaagtgacc atgccaaatt
103321 ggaacccaag tctgtctgcc tctggaacct gtactctttt tgcacctcca gtcagtagcc
103381 tcattctcca aagcattctt gaattctgtc caagttgtgg atgcatctgt ttcccatctg
103441 aactcagact gccttgagtg tgaaggggag aacgtagtga agagacaggc agccttggcc
103501 tgaccagcaa ggacaggggt gggaacgtca tcgcttcgtt aatggaagtc tgcagccttg
103561 tcagagtctc ctcttactgc tgatttctca tttttcttgg ctttctcctc taagcagagc
103621 acaaaatcct gataatagtg aaggaaaagt gcccttctgg aacagcaaat cttggcccct
103681 gaggggagaa ttggaggcag tggttactaa tgagcatttc ttatgttaat caaaatactg
103741 ttagcgccac atactgcaat cacagtaaaa tgattacata cctggattgt atggctagct
103801 ctaggattct tttgtgatga cgtgccagat gcttacctgc aaaaattatg tgagaaataa
103861 aatggtgctc tgtcagtatg atttaatagt tcgccagcca aaatctaaaa ctaaactaga
103921 tgatggggag gaaggtgtaa tacagcatag tcatagctca ageacagate ctcaatctgc
103981 aaaattgcag caatgattta ggcattgcag tgaggttctt tttgtaataa atgctctatt
104041 tttacaggat ggatgaacag atagagataa ctatagagct tgatgatcaa gtgtacgtac
104101 tttggaccca gtttgtattc tggctctacc atgtgccata ggtgtgtggt cttggtaaat
104161 tacttccctt acctaatcct cagtttcctg ttctgcaaaa tgggaattac cggatttacc
104221 tcgcagggtt gtgaagatga aaattgattg tgtgcattag gtacttacag tgcctggcac
104281 ttagcaaagc aatgaatgct tgttacctga cattcttctg tgtctaagtg atcgtttcaa
104341 aaagtatagc ttattgtaat aagcagcaac tgtgtgttgc acattaggct cagagagatt
104401 cctacagttt ggcagtcagc cttctgaact attgaaatta gatccctaag taagttaggt
104461 aatatgtggt taaaggcatc tttgtgggtt tatttccctg aagaaacaga taaggttaaa
104521 tttctctgtt gggacttaat tttaactaac ttctctacag aaaaaccaaa ttatttattg
104581 caacttcctg tgaatctata attattttga aataaagact agaaagaagg agttttttaa
104641 aaagttctct gacttcagag gtaagggaga gggctcagcc tttatagtgt tggatgacat
104701 tatgtgataa atgcatataa agttcagctt cagtcagctt aagagaactc aggttaacct
104761 ttctctgtct ctagactggg attgagaatt ttttcgaatg tttgtttgtt tactcattca
104821 gcaaataact tattgagtgt tttgtatgtg ttagtgactt ttccaggcat ttgggatata
104881 gcagtgatca ggatagacaa aattttctgt cctcctgggt tttatgggat agcatggggt
104941 agggtgagag gcagagcata aacaagattg atcaagcata atttggaatc gtttcatgtt
105001 aaaacaaaat tgctaagctc tgtctccttt tctaggtcct tttcttcatt tctcattgaa
105061 cactttcccc acaattttac ttgagctgtc ttttcttttt aactgggaat ctccttcaaa
105121 tccatggaag atgaacctat attactcaaa cacagaaaga ctactataaa aatgaatcag
105181 catcctggtc ctatagattg tctgcataga taatcaaatt agaatgagaa agttgtttgg
105241 gctcataatg gtctaatgtc attggtcaga ttgcaaaacc acaatagctt caggcttcca
105301 tctccaggat gggctttgtg gttgtgaagg gcagatcttc ctttcctttg ggtcttgctt
105361 gaaggataca ttcattgagg gaacagctgc tataacaaat aggccccaca ttttaatgac
105421 tttgcacagt aggtatattt ctcactaata taatagtttg gcaggccgct gtcctcagca
105481 tggtgattca tgcaccagag ctccttctgt cctgtcactg tgccatcgtc tgttcagtgg
105541 gcacatagga aagagagtag aggagtgcta cagggtacta gtcctgcttg gaagtagggt
105601 aggccactgg tgctcacatt gcaatggcta caactcagtc acatggctgc atgtaacttc
105661 aagggaggct ggaaaatgtc atttctggtt gggcagccac ttagtgacac etetacacca
105721 ggcatagtag agcatgaatt attggaggag tctgctgtaa tcccacctat cagcactgcc
105781 accacttgct tctgtgactt ttttttctca gccccatgac tgaccaattt ccttgatctt
105841 tctttagaca aattgatatt cacttgggct atagtgtagt ctcaccagcc cattagctat
105901 ccttttcttt acagtagtca agtcttctca catctttgct aatgagatcg ttttgatcag
105961 caattgcctt gtggtagtct tatttccaaa atatttttgg cggaggaggc atcctcagat
106021 attcactgtg ggcttagtat gagcttttgc tactccaaat agtttgttta ctaaggcact
106081 aacaggacac tgttaaaaga tcattacccc tcataggtga aatggctgga ctctaaaaca
106141 gcatttatag gatgccttcg gggtaggttt atattttaaa cagaaatgtt ctatgattga
106201 aacaatacac acacccttct taagttctct ccaacaatgc ttccttgcaa ttcatattat
106261 ttagctttgt ttgattttta agatagtttg atagtagggg taaatgttac cttttgggat
106321 tttattaata gtattacttt ttaatgagtc ttttgaagtc tttcattata aacagcctgc
106381 tttccccaga gataataact tgccatgcca aatatttgca tttcacttga aacaaaacca
106441 aggggttgaa tgttttaaat ataagcaaat ctaattctcc tgtgtctaga gaaactgtat
106501 aatgaaccat atgtatgtgg cttaagcaga cagatgtgaa agatttctcc ctctctcctt
106561 ttatttaaaa aacaaaacac tggcagagct caaaattggc accaagtagc aaaYatctct
106621 gctcagccaa caaaaccact ggagctggag ttgatggggg gaggcctctt tagggtgcat
106681 gcaaaagtgg agcttttcct ggtcctggct tctacttgga aagctaaggc tccacagctt
106741 atttgccctc atttctcagt gccttcaggc ttcaaaatga gccattctca ggtgactgac
106801 ttttcagatc tttgagaaga ttgttgtggt tgattgttgg actggttcag aagacatggg
106861 tccacgcatc tgggtcctgc ggtgacatgg cctctagctg ctgacagagt ggtgctgagc
106921 taccaaacag actcataggc ttcctttcac aaagaacatc atagggcagt gtttccacat
106981 ctcttgcaat acaagacata cctctgaact tcctcaagct tgccaataag tagagctcac
107041 actacctttt agtatctgtg atgtacctgc cagggactat aggtgggata aagtatctga
107101 tatggctcct gtccttcaca ttgaaacctg ggtgaagatg tttaggaaca ctttaaatgt
107161 tcaaactgtg gtacttacca tgactatcat aaagattcat atatattttt ttgagacagg
107221 gtcttgctct Rtcacccagg ctggggttca gtggtacgat catggctcac tgcagccttg
107281 acctcctgcg ctcaggtgac tctcgcacct cagcctcctg agtagctgga actacaagtg
107341 catgccacca tgcttggcag tttttaaata ttttttgtag agatggggat ttgccatgtt
107401 gcccaggctg gtctcaaact cctagagtca agtggtctgc ctgccttggc ctcccaaagt
107461 gctgagatta tgggtatgag ccaacatgcc cagccaagat tcatattttt taagacgctc
107521 aaatcacttg gcttagtaaa tcaatttcaa gcatacagcg agaagcaagg ggaaagagat
107581 gggggggtag gttagcacac ttagtgcaaa ccagtagaag ggccactcta tgggttacac
107641 agaactcatg tgccctctcc ctttgtccta aggcctttct aggtttagga gtaggaactc
107701 tccttgccca cttaagtttt cttggaagag gggttgggtt ctcatgggaa tctaagaaat
107761 gagagccaag gaatggccca ctggtctgta ggggtgggag ttcttggctg ttcatgcttg
107821 ttctactgtt aacaggcctt gccctggttg tgttaagttt gctccactgt ccacttatct
107881 ttaggcttct gcagcctttc ttgccccccc ccccggcttt gtgtcctttc tgtacctacc
107941 tcccagcttg tgctgatgct tggttctggc gccctcataa ctttaagtcc cacctaccct
108001 ttctctatac tacagcccca ctgagcatct gtttagggtc tactttctct tctcattggc
108061 cttgatattt ctcatccaca ttcccaagaa tgagcatctg acctaagccc ttgtcagagc
108121 atctcaaagg ccagtatact gtgtgcccat gaacccttac tcccactcag gtgacgccag
108181 gtgtgaggtg ggtcatggtg cccacacaag gctgccaggc ccacctttgc agcagagcat
108241 gggaacgagc agtgccgtct gtcatggccg tgggtacggc aggtacattg gaggatttga
108301 gcaggggaag agtgttctgg gaagaagaca aacatcttac ccctgaggag tgagcatgtg
108361 cagtcggaaa gcctgctgag aggaggctgg ggtgcgaggc ttctgaaggc caggtggagg
108421 aggtggactt ttctgttagg cagcaggtca tctctgcagg cttttaagca gaggagttaa
108481 tcaccccctt ctgttcattc ctgatttctg ttgttagagt agacctgaga cctgcctgct
108541 aagaggccac taatgccacg ctggagtgag gtgatgtcaa gaggagctag aaagcagatg
108601 gttatggcat tgaggaaaga gcacacatgg gctgacaggg acagctaagc agcagcttca
108661 tgagcaggag ggaaagggcg tgttctaggg gagcagcagc ttccatgtca gactcaggaa
108721 tgcagcagac ccaacatcca gcttggagat ttcttctctt tttctttttt ttcaatggaa
108781 ctgtattttc gcaaaatgtt acagatcact tatagcaaac agaatggtga tggtcaagga
108841 aactgactct gggctccttt ttgaccgcag cagctatgtg gaagcagctg cagctgtgat
108901 aagggccgcc cagcatggat atttctgtgt cttcgttcac tgggaagtgg agggacagag
108961 cttccgaccc acatcccacc ttcttcacga atcatctttg ccaccaaatc gttggctcat
109021 aggtgtctgt tcttgtcttt cctgcccatg cctggctttt aggttccttt gctccRgctc
109081 tttctgtcag ggctgacctg gagggcagtg ctcctgtgag ttctccacat tatatcatgg
109141 ccggtaatct aatccaattc aagctgacat tctccaccct atgttctacc aatggaacct
109201 ggtcagacat ctgggctcat tcaggaagtg ctgctagggc atggctctgg aatttggtgg
109261 gagtattttg gaaggttgtg tggtctgttt ggttgtttag tgctcggact ggattttgat
109321 tttttttgct ttacttattt ttactgagac ggagtttcgc tcttgttgcc caggctggag
109381 tgcaatggcg cgatctcggc tcgctgcaac gtccacctcc caggttcaag tgattctcct
109441 gcctcagcct cccgagtagc tgggattaca ggcgcctgcc accacacctg gctaattttt
109501 tgtatttttt tagtagagaY ggggtttcac catgttggct aggttggtct tgaactcctg
109561 acctcaggtg atccacccac ctcagcctcc caaagttctg ggattacacg tgtgaaccac
109621 tgctctgggc ctgtttattt ttataataat aagaggtttt tgaaaaaaat tcagatagat
109681 gcaacccagt taaaaaaaat cccggtatac aaaatcctgc ctttgaataa gagattaaaa
109741 aaagatggtc attatttgct gcctgcaggg gttcactaag ggatatgggt aagttccctt
109801 agctcggaaa aaggataata attaataccc gcttacatct ccaaagtctt gaggtgctca
109861 aacaagtagg agtgtgtgaa atgctttgta catatcaaaa cactctgtga aatttaaggt
109921 attaactaat ggataatgac ttcttgaaca tttaagagtg gtttgattta cgtttagtag
109981 aaactcatct agtatgaaaa tgatacattt attacaaatg attaacaacc ctacagctct
110041 caacctcttt atgtaacctt ccttctgact aaaggaccca gatgactttg aggaatagcc
110101 tgtttgctgg gtgcattctc actcagcact tctggaagta tccattctac agttagtatt
110161 tcatctcatt gtcctggcct tccgaaagca cccttaaccc aaggtgtgag atatcaaagt
110221 aatacatatt ttacttcaga gatgacatct caaggtttta cagtagctca acattttcta
110281 gtctcctttc tctgaacatt gtcagagggg agacaggcgt tcctgggaag aattaattcc
110341 tggaatggtg tgtgtgtgtg ggtgtgggga atgggaggag atggccggcc ttcttttcta
110401 gggttagtgg gtggaattgc ccgcccaatg attaattccc tccttgacag tgtgttcaga
110461 agcaggcacc ttgatggctc tttagcagca ataccctcct cttctttcct agcctccttt
110521 tgtcataaag cctcatcttt tttatttatt tttatttatt tttttttttt tgagacagag
110581 tctcactctg ttgcccaggc tggagtgcag tggtgcgacc tctgctccca ggttcaactt
110641 ctgcctccca ggttcaacct ctgcctccca ggttcaagtg attctcttgc cttagcctcc
110701 cgagtagctg ggattacagg cacgcaccac catgcctagc taatttttgt atttttagta
110761 gagatggggt ttcatcatgt cggccaggct ggtcttgaac tcctgacctc gtgatccacc
110821 tgcctcggcc tcccaaagtg ctgggattac ttgcgtgagc cactgcaccc ggccaagcct
110881 catccttctg gtgttcacct cttggtcctg ttaaggtggc ccttggcaag tacctcttta
110941 gtcttagggt tcatgggagg gatagaacaa aggcccacgc ctccccctag catcgacatt
111001 tcccttcgtc tgccaatgcc taccatagct ttgttttctc ccgcactgct tccctggttt
111061 tctaggctct taaatcctca aatttgactt gcatgccctc tagtggcagg tctgatgcac
111121 cccttgttac cctgtttatt gtggtaccat aacagctgtt ctcaccaccc agctctgtta
111181 ctaaatattg tctgtaattc acaaatgccR aatgagaggt tcagtggtcc tgacttgcca
111241 ctcaagtagg agctggaaat gtgggatttg aattggagct tttgattcct ggatttatac
111301 agcatttcag tgtaacggca acagtaaaaa agatgtggtt atagttgttc tagtttcttt
111361 tttgtcattt aaaaagaatc cagattattt tactatccac tcagctaatc tgaaagaatg
111421 aaaatgtgag gaatagtgga aaataagaat gatcatcttt ttttaaaccc tttattacaa
111481 ttagaaattt ttttgtcact tactgagtat tcagtatttc atgcctcagt cctgttaact
111541 ttgaagaata caaaaaatac ataaagcatg atgtctgccc ctaagtttct gttctagtta
111601 gattctagtt atgaggcagt taaatttctt cacctgagga aaaaaattaa gcataacaca
111661 tgataacttt tattggtgtt taatttttct acttctcact aaagacaggt tctctgagca
111721 tttacttttt aatttattct tacagtcctt ttcagtggag agggaactac aggataacag
111781 cagttacccc gacgaaccct ggaggataac agaagaacag cgcgagtact atgtcaatca
111841 gttccgatcc cttcagccag acccaagctc tttcatttca ggtaagaatg tgggctccct
111901 aggcatcact ctcaccagaa catagccacc atcttgagaa atcattcacg caaaatgagt
111961 atggcagcct tctgtgattt cagtttgttt ttcatctaaa gtcgaatttc ttatcagatg
112021 taaaccatgc agaagaaaag ttgccaatga cgtttggaaa attatatttc catttcaaag
112081 ggcttaagtg ggaatttggg ggcaacttgg cccagaccct gcaccttatc agctgaggca
112141 gttcttgaaa tgctagcgtg tcgccccaag gggccacctc tcattgcttc ctcgttatat
112201 tagagctcgg gcaaggacag aatgtggcct cctaaggagt tggtgtcaca agtcttttta
112261 tgttatatgt gccttcaaac ttcaaactca ggctcgtttt ctttggctca aatgtttgtc
112321 ctccagtttt tctgagagaa attaaaatgg gggaggaaaa ttggccagtg ctttcccact
112381 tgtcagttct tctgggttgt cttcagatat atagattcct gttgagttct catgtaaaat
112441 tcaagctcag aggaactggt ttaatgccag tgtggctaca ttttaccagg ctgaaagact
112501 aacagtgaaa tagtagagtc tagaagaaaa attcataaag ctttcttttt agactttaaa
112561 atttgaagaa taacaatatg tccttaataa ttgtaacctg ccatattgaa gtgtgggcaa
112621 agattagttt tatcttgtga aatgaggcac ataattgaaa tatacttgta taagtaattg
112681 caaacatcat ttactgattg gtggtaatgg ctttattgac ggcagaatag tacagataca
112741 acaaattaat gttgacgtca tgattaagga aaataagcag aaacccatat tgcacgattt
112801 gaccacttgc taaccttacc ccgtgctcag gtgagtttct ttacgacatg tgcagatatt
112861 tagccaaata caaacaggta cttgttagaa atgtttttgt tttcttttaa cttttgtatc
112921 ttgcagaatt tcagatatag acacaactag tctggctgat acaacaaacc tctgtgtacc
112981 tatcacatag ccccaatgat tttctcttac ctacagttaa cacataaggt tgtttcagtc
113041 agtcaatgat ggcggtacca taacagtatc acggagctga aaaattccag ctccattaat
113101 cacctagtga tgctgtagcc atcatgatgt tgtagcacaa ggcagtgctc acataaatgt
113161 gatgatgctg gtaaaaacaa atctgtgcta ccagtcgtat aaaagcctag cacatatgat
113221 tatgtacagt atataatact taataataaa tggctattat tagcttatta tgtatttatt
113281 atgctatact ttttttcttt cttttctttt ttgagatgga gtcttgctct gtcgcccagg
113341 ctggagtgca atggcacgat cttggctcac tgcagcctcc gcctcccggg ttcaaatgat
113401 tcttctgcct cagcctcccg agtagctggg actacaggtg catgccccac accaggctaa
113461 tttttgtatt tttagtagag acggggtttc accatgttgg ccaggctgct ctcaaacccc
113521 tgacctcgtg atccacccac ctcagcctcc caaagtgctg ggattgcagg catgagccac
113581 cgcacctggc cttttattat gctatacttt tattgttatt ttagagtata ctcttactta
113641 tatataaaaa aaagttaact gtaaaacagc ctcaggcagg aacttcagga ggtattccag
113701 aagaaggcat tgttatccta ggaggcggca gctacctgca ggttattgtc ctcttctagt
113761 cacctccaca gtatagaggt ggaagacagt gttattgatg gtcctgacct tgtgaaggtc
113821 taggctgata agtgtttgtg tttcagtttt taaccaaaaa gtttatacgt gtttgtgttt
113881 cagtatttaa ccaaaaagtt taaaYggtaa aaaaattaaa aattttaaaa atagaataat
113941 agaataaaga tataaagaaa gaaaatattt ttgtacagct gtgcaatttt tttaaatttt
114001 taaatttttg tgggtacata ggtgtatata tttatggggt acatgagatg ttttgataca
114061 ggcacacaat atgaaataag cacatcatga agaatggggt atccatttcc tcaagcattt
114121 atctattaag ttgaaaacaa tttgactaca ctcttaagtt attttaaaat tgtacagtgt
114181 gtttttgttt taagccaagt gttattacaa tggagtcaag aaggttaaaa taaattttaa
114241 agtttatgaa gtaaaaactt acactctaag gttaatttat tattgatgaa aggatttttt
114301 tttttggtaa atttagtgta gcctgagtgt gcagtattta taaagtctac agtagtgtac
114361 agtaatgtcc taggccttca cagtcactca ccactcactc tctgacttac ctagagcaac
114421 ttccagtcct gcaagctcya ttcatggtaa gggacctaca aaggtgaacc atttttcatc
114481 ttttatacca tatttttact ctgccttttc tatgtttctt ctttctttct tcctttcttc
114541 cttYctttct ttctttcttt ctttctttct ttctttcttt ctttctttct ttcttttttt
114601 tttttttttg acagggtctt actctgtgcc taggctggag tgcagtgatg tgatctcggc
114661 tcactgcagc cttgacctcc tgggctcaag tgatcctccc acctcagcct ccctagtagc
114721 tgggactgca ggtgcacatc actatgcctt gcctggctaa tttttttgta gagaggaggt
114781 ctcactatgt tgcccaggct gttttctata tttagttgtg tttagataca caaatagtta
114841 ctattgtgtc ccaactgcct atagtattca gtacaggaac atgccRtaca ggtttgtagc
114901 ctaggagcaa taggttctac catctagcct aggtgtatag taggctatac catctaggtt
114961 tgtgtaagta caccctgtgc tgttcgcaca atgaggaaat cacctcatga tgcatttctc
115021 agaacgtatc cctttttcta gaaatggaat ctcataatat gtggtctttt gtgtctcttt
115081 catttagcat aatgttttag tttttttttt aattaaaaca tttgtgtggg tacataggtg
115141 tatatattta tggggtatgt gacatgtttt gatgcagaca tgcaatacat aataatcaca
115201 tcatggtaaa tggggtatcc atcccctcaa gcatttatcc tttgagttac aaacaatcca
115261 Rttacattct ttaagttatt taaaatatac aattaagtta ttgactatag tcaccctatt
115321 gtgctatcaa gtagtaggtc ttagtcattc tttctaacta gttttttgta cccattagca
115381 atccccgcct cgcccctact ctctccctgc cactacccct cacagcctct ggtaaccttc
115441 cttctactct ctgtgtccat gagttcaatc attttgattt ttagatccca caaatgagaa
115501 catgcgatgt ttgtctttct gtgactggct tatttcactt aacataatga tctccagttc
115561 catccatgtt gttgcaaatg attggatctc attatttttt tttaatggct gaatagtacc
115621 ccactgtgta tacataccac attttcttta ttcatctgtc aatggacaca taggttgcct
115681 ccaaatctca gctattgtaa acagtgctgc agcaaacata ggagtgcaca tatttctttg
115741 atacactgat ttcctttctt ttaggtatat acccagtagt gggattgctg ggtcatatgg
115801 tagctctaat tgtagttttc tgaggaactt ccaaactgtt ctccatagtg gttgtactaa
115861 ttcccaccaa cagttagcat aatgttttaa aggctcattc atgttgtatg taccagaatt
115921 tcattccttt ttatggctga ataattccat tatatcagta catcccattt tatttatcca
115981 ttcatcagtt gataggcata tggtgttctt ccacttttgg agtattaaga ataatgctga
116041 tttgaatatt tgtgtaccag tttttatgtg aacatatatt tttatttctt ttgaatacat
116101 acctaggagt ggaattgcta gatcaaactg tactgggagc tgaaagcatt caaattcaat
116161 ctcagtaagg tctaacattt caagaacagc tgggtcttgc agttatgtaa catgtaaagt
116221 ggaatgattg cctgatttca gttgatacag gtaaatcaac aatgaaggaa gaaagattcc
116281 tggataagtt tctcaaaatg ccactaggaa ttcttaaatc tcaccaaaag ctttcccaag
116341 atgtctgtct tatctctgtg tggtgtgatc aatggtatta attttcttct ttttggtcag
116401 ttttctatta cttttctatt tgaaatttct atttgaaatc tgccaaattt gttcaaagtt
116461 ttgaacttcg tcttctaaat ttttggaaaa attttgcaga ttttggtaaa aatgaagcag
116521 aaattaattt atgtgatttg catctttcat gagcattatg ttattgcttc ttttgcccta
116581 ttgtaattta catattttta aaaaagctat tcatgtgttg cttttggtcc catgattcat
116641 aattgctttg aggaataaat atgtttgtgg ttatacagaa gagattgctg aatgaaaaaa
116701 ttgtgattca tttgtatata aatgtaaaag ctactctagc tgagtaatta atggtttatt
116761 taaacaatgg cacttgacag gttctgtggc caagaacttc ttcaccaaat caaagctttc
116821 cattccagaa ctctcctata tatggtaagt acaattaatg ccatatgaca ttcataccat
116881 catccataac tcatccttta gttcctacct ttgcattttt taaaggctta tgttttgaat
116941 gatgttttta acagactaca ggaRtgaata caactcagat ttttgttgct gtgaaaatta
117001 aatgttatat gaaaagtaca atgaacaatg tctggcacgt attaagcact atgagtgtta
117061 actattattt taaagtaatt tcctaattat tatccccatc tcaatccctt ttcagtctag
117121 gcagttgtgg gcacatgaga cttaccatcc tgtagatttc attttcagac ttttctgcta
117181 ggtgtgatac aagtaaccag aggagcttga caaactattt tttatatttt ataaggctga
117241 gtgaacagaa ggttgaggaa tattttggag ttaggttaga tttgactatt ctagctgcct
117301 ctgagctttg caaatttggc tggtgtttat cagttgggcc ctaattcaga cttgcagctg
117361 tggtatccac tgcaccttta tgcactctgg ttccaaaagg gctatgctgg gatggtccag
117421 atggctctat ttgcattcat gaaaatgctt ggtgctgctg taaactctcg gctgtgtgtg
117481 ggctagttct tccccaaaac tgggcaggag atcgcactgc tataaatata taattaaaaa
117541 cattataatg tttatataaa gctttttgca tgaggattta cagaattatg ataggattta
117601 aaattgcttg tcatgttttg tgcatcttat tggaaaacta ctccaataat actcatgcat
117661 gtcaatgtat ctgggattct gagctggatt taggttcttc aacaatatat actctggcat
117721 aatttttttg tttttacaag ccttatatta gttttgtttt tgttttgttt tttgtttgtt
117781 tgtttgtttt tttggagatg agggctcact ctgtcaccca ggctggagtg cagtgacatg
117841 attatagctc attgcagcct ctgactccta agctcaagcg atcctcctac ctcagcctcc
117901 cagctagctt ttcatttttt tctagagaca gggtcttgct atgttgacca gtctggtctt
117961 gaactccttg cctcaggcaa tcctcctgcc ttggtttctg aaaactctgg gattacaggc
118021 atgagccacc atgcccggcc cttatattag attttctggc tagggaagaa taaagaaatt
118081 atcattttga aaagaatacc atttgttttg gcagaattcc cagtctaaac attgttggca
118141 tgagacctcc tatctttttg ttgagacacg cctatgaaag ctgaatggta ttctttcgat
118201 ctggcgtatg aagcagtttc ctgacccctc actctgggga acagctattt cagggcccca
118261 gtgcattcga aattggagga ggaggatgta aatggtctaa aggaaagtta tggagcttac
118321 cttagaaata tattttcttt caaatagtaa tacctttcta gaataatttt gtatttgtct
118381 tatctctatg cttgtcctaa cacaagtaca cttgtccctg tctacctaag agatggttaa
118441 gcttatgggg tcttagatat aatactttgg caaataagtt tcttttgtgc tgagtaaata
118501 ggtctgtgcc ttttagtggg aaataatgac tgaagttaag cctgtttgag actccccctt
118561 tcttcctttt tgtcttatct ggttccagtc agctttagtt actagtttta tcctaaaaca
118621 taattcattc cattttttat tgagcttact tgtgttttcc caggagggag ttctcaagca
118681 aagaacagtt tggtacaaaa atttacgtga cttgaaaagt tcacggtttt cctttaaagc
118741 tgaaaaacaa agagcttatt tctgtgctcc aggtaaactg cataatggct aggacaacta
118801 taaaatggct ggggccaccc ttcctctgac tgttttgaac accatgtcca gggcttttca
118861 ccccatgcag cctgcattta ctgaatgact gtggacttct gggtatcatt tttatttctg
118921 tgccatagtt tcttgtccta tgtcctcagt gttgtaagac acaccaacta gggaacctga
118981 agaatttaaa tttttattta taaaatgcta ctgatgctga tcccatcaat cggcattttt
119041 cttcctcgga gtggccccca gagatttcaa atggatttgg ctaggagggt ttgggtatct
119101 ggtagggcca tcaccacaga gtctgggagt tttattggca cgtttgggcc aagtaacttg
119161 ttctgtaagc cccatggtag gtactcatga catttgtttc atttagggag cttagtgatg
119221 ctgactgtga tggagccctg accctgcctg agttctgtgc tgcgtttcat ctcattgtgg
119281 ctcggaagaa cggctaccca ttgcctgagg gcctccctcc aactctgcag ccagaatacc
119341 tgcaggcagg taaggcctca ccatcaaYtg taaaccttaa gtacttttcc tccaggctgt
119401 gtaaaaaact tttgtttcct gactttttaa tgattgccat tctaactggt gtgagatgat
119461 atctcatagt ggttttgatt tgcatttctc tgatggccag tgatgatgag catttcttca
119521 tgtgtttttt ggctgcataa atgtcttctt ttgagaagtg tctgttcatg tccttcgccc
119581 actttttgat ggggttgttt gtttttttct tgtaaatttg tttgagttca ttgtagattc
119641 tggatattag ccctttgtca gatgagtagg ttgcgaaaat tttctcccat gttgtaggtt
119701 gcctgttcac tctgatggta gtttcttttg ctgtgcagaa gctctttagt ttaattagat
119761 cccatttgtc aattttggct tttgttgcca ttgcttttgg tgttttggac atgaagtcct
119821 tgcccacgcc tatgtcctga atggtaatgc ctaggttttc ttctagggtt tttatggttt
119881 taggtctaac gtttaaatct ttaatccatc ttgaattgat ttttgtataa ggtgtaagga
119941 agggatccag tttcagcttt ctacatatgg ctagccagtt ttcccagcac catttattaa
120001 atagggaatc ctttccccat tgcttgtttt tctcaggttt gtcaaactat gcagccataa
120061 aaaatgatga gttcatgtcc tttgtaggga catggatgaa attggaaacc atcattctca
120121 gtaaactatc gcaagaacaa aaaaccaaac accgcatatt ctcactcata ggtgggaatt
120181 gaacaatgag atcacttgga cacaggaagg ggaatatcac actctgggga ctgtggtggg
120241 gtcgggggag gggggaggga tagcattggg agatatacct aatgctagat gacacgttag
120301 tgggtgcagc gcaccagcat ggcacatgta tacatatgta actaacctgc acaatgtgca
120361 catgtaccct aaaacttaga gtataataaa aaaataaaaa ataaaaaaac aaacaaacaa
120421 aaaaaaaaaa caaaaaaact tttgtttctt aaaatgatgt ccagatactt tggggagtcc
120481 ttggtattta cagttattgt tctttaactg ctattagact ttcacatctc ataatgtgag
120541 gaatagggct gatctgggta agtgtgtatt acctgttttt ctcattctat accctctgga
120601 tggatttgaa ccaaagtcac ttaccctttc atgacagttg tgaaataggc aagtactgaa
120661 cctcccagct ggtataaaat gaagaggaag atcctgtaga gccaagtgtt aacttggcat
120721 ttttaggcac acccgagtgt ctccgggtgg ccctgggcaa tggagtggaa tggaactctt
120781 atacctaatt taaaagtcaa aaaattagcc gggcgcagtg gctcatgcct gtaatcccag
120841 cactttggga ggccgaggcg ggcggatcat gaggtcagga gatcgagacc atcctggcta
120901 acacggtgaa accccatctc tactaaaaaa tacaaagaaa aaaattagcc gggtgtggtg
120961 gcgggtgcct gtagtcccag ctactttgga ggctgaggca ggagaatggc atgaacccgg
121021 gaggcggagc ttgcagtgag ccgagatcgc gccactgcac tccagcctgg gagaaagagt
121081 gagactctgt ctaaaaaaaa aaagtcaaaa aattacatgc agtgaaatgt gcaaagtgtt
121141 gtcaccttaa atgtatgctt gatgaatttt tgtatatgta tacacccatg taactacaat
121201 cagatgaaga tatagaatat tctagcatat cagaaggtta gaatagaact gttatatttc
121261 tccttaataa aacagtctcg ctcaaattat tgttttggac cctttagatg ggaaagagtc
121321 atggtgagta taacatatgt attaattcct ttgggagagt agaaaaatta atagtgtgtc
121381 ttgccctttt caaaggcaaa tgggcactgg tctgatttcc attattcatg gaagtatagt
121441 gctcattgag aggccccaga aacagctggt gctttcaaca acctttctca ctttttaggg
121501 aagggctgtt aaagaaatga gagcttagtc atgggtgatt attagcaaga gagagcagtg
121561 tctaaagaaa ctttaattac ttattagtag agtatgaatt ttgtgattag atctgcaaaa
121621 ggccttagat tatcttgtct agccccttcc tcatgatgac accagattca aagtggcaaa
121681 tgtcttatct aagtttgtct cggggcctct gactctctta aataaaaagt ctgtcatttt
121741 ctgtgttaaa tagtgagagg agaggaactc aaccaaaggg cagaggccaa gtttgtggct
121801 gctgctaagt gacaggtaaa catgttgggg gaagagtgac ccattctggg atcttcttca
121861 aatgtcctca taaaatatgt gaaggggaga gttcagagag caaaacctac taatttctgg
121921 acttggattt tgctaacaat acctgctttc tgcctattgc aggctgtaac tctagcctgc
121981 tgcccttcct tagatgcttg gaagactctc atgggtccca ggaattagct tgcaattgag
122041 gagcatggga aactcctctt ttctctttgg tgtctttctg tctccatttc attctctccc
122101 tcgtcttgtc ttgtcttgtc tttttctttt cttttctttt ctttctgttt cttctgaatc
122161 agggcaaaga agcactggca ttctgggggc tatcttgacg cctacatggc tctcattgcc
122221 aaggcagtgc ggggtcatag aggagcccct tttcttggga ttggagacac atggggcttt
122281 tgtctctctc taaagggaat taatagctgg caaaRggcca agttctgttc tagggttata
122341 tttaatacct tcgccgtgtc ctctttcaag ccctggagag agtcctgggt aacctcatct
122401 cccataccca cactgagttt tctgtttggg ggtcatgact agtactgttt tattgttttg
122461 atgccatatg gccatggaac ctgtgggaca tgccatgact ccttatttga taagtcactt
122521 ttgtaggtgt ccaagtgttt cacagactat ttcaaaagtc actgacataa cggctgggtg
122581 tggtggctca cacctgtaat ctcagcactt tgggagtcca aggcaggtgg atcactggag
122641 gtcaggagtt tgagaccagc ctggccaaca tggtgaaacc ccatgcacta aaaatacaaa
122701 aattaaacag atgtggtggc gcacacctgt agtcctagct actagggagg ccaaggcagg
122761 agaatcactt gaacctggga ggcagaggtt gcagtgagcc aagattgtgc cactgcactc
122821 cagcctgggt gacagagcta gactccttct caaaaaaaaa aaaaaaaaaa gtcactgaca
122881 taatttttag acatctgaaa gccctgagct aaaagtatgt taacaggaaa gaagtaatct
122941 cttgattcct ttcctactgc caatggcttc ttttgacctg cttattcagt agaggggaat
123001 ctataaaaaa gagtgccaat gagccccatg tttcttcctg gacttttatg gagactgtca
123061 gcatgcattt atacaggaac aagggaagaa tccatcatat acacttcaat taaacaaaaa
123121 ttgcacatca tttctagggc ttgtgggatt aatcttaaat aataattata tagttctaac
123181 agaaaacatg aaagaaccca taaaactcta tcaaactcag tgacggtata ttttaaaatg
123241 ctttatcacc tatgtttatc attgtatgaa gcttaagaaa atggccagaa ccacctaggt
123301 ctcctctgtg ctttttttgc ttttctttgc aaaatatgag tgatcctatt catttttttg
123361 ttcattttaa tggcatctca tttagtgttt ttcttttttc tttctttctt tctttttttt
123421 tttttttgag acggagtctt gctctgttgc ccaggctgga gtgcagtggt gcaatctcgg
123481 ctcactgcaa gctccacctc ctgggttcat gccattctcc tgcctcagct tccaaagtag
123541 ctgggactac aggcacatgc caccatgccc ggctaatttt ttgtattttt agtagagatg
123601 gggcttcacc atgttagcca agatggtctt gatctcctga cctcatgatc cacccgcctc
123661 ggcctccgaa agtgctggac aacacgcccg gcctagtgtt tttttttttt tttttaaagc
123721 ttaactctta cctttttcca acttttttct aattgatcta tattcagtct ttaaaaaatc
123781 taatccagtt tttgataaga ttggtgaaga gtataaattt ggttgatatc ttcatgcatt
123841 cataactaga caagcttgtt ttctaaaata ataatttttt ttttgagatg gagtctcgct
123901 ctgtcaccca gacttgagtg cagtggcatg atcttggctc actgcaatct ctgcctcccg
123961 ggttcaagca attctcctgc ctcagcctct cgagtagctg gaactacagg tgcctgctac
124021 catgcctgac agatttttgt attttagtag agacggggtt tcaccatgtt gaccaggctg
124081 gtcctgaatt tctggcctca agtgatccac ccacctcggc ctcccaaagt gctgggatta
124141 caggcatgaa ccacccacca cacctggcct gttttctaaa ataatggaac aggaattgta
124201 tctgatgcca ttttacttgc aattatggaa atagtccctt ttccctaata gtaaaacttc
124261 aaggacagag ttgtattagt tggtggctta cccgctagcc ttttgatagt ttcatcaaaa
124321 gtctcctttt gatagtttca tcaagagtct ccttttgata gtttcatcaa gagtctcctt
124381 ttgatagttt catcaaaagt ctccttttga tagtttcagc tgggtggggt ggctcacgcc
124441 tgtaatccca gcactctggg aagctgaggc aggaggatca attgaggtca ggattttgag
124501 accagcctgg gcagcatggt gaaaccctgt ctccaccaaa aaatacaaaa attagccagg
124561 tgcggtggcg tgcacctgtg gtccccagct actcgggtgg ctgaggcagg agaattgctt
124621 gaacctggga ggcagaggtt gcagtgagcc gagattgcgt cactgcactc cagcctgggt
124681 gacagagtga gattccattt caaaaataaa ataaaataaa aataaaaaaa taaaaaaagt
124741 caccttttga taggtgattg ggtgggttct ggtagaaatt tttgccatag agtttgttaa
124801 aaaataccta tggagtactt actgcgtgag aggtaccaca ttgttcactg tggtcagaat
124861 gctgtatgac agagctccta ctcccatgaa cttgtgggca gttgatacgt gccatgaagg
124921 ggaagtacag gtgcagcaag agggtgcatg atcttaggga agatttcctt aaacgtttgg
124981 gctgagatgt gaaggctgag ctaaggacta cataggtgaa gaagagagaa gcttaggttc
125041 tgggaagggg gaacagcagg tatgctgggg aggctctgag agggggcttg gagcatagga
125101 ggagtgggaa tttcaggcca cagtggctgg cgtgcacaga accggggtag agaggctggg
125161 ttgaagctga ggaagaaggt ggggaacata tgacgggcaa taatgtcacc ttattttagg
125221 cagataagtg acacaatcag atttgctatg tgaaatgatc atgcaggtta ctgtccagag
125281 aacaggtttt gaggggcacg ggtagaaacc agaagactaa gttgtggtag ctggccagtc
125341 aggagcagcg gggtgcttgc aatggggagg tgacagtgat atggagagat gtggacacct
125401 tggagagaga tttagcaggt aattgacaaa attatagttt tggaaagtgt tagctttctt
125461 cacaggaaga tccgctcatg ataaagcatc agtcatataa taccagtcag agccttgatt
125521 gatagactag aaagagaaat cggtgaaatt cagaccagag taagcaaatg aacaaattaa
125581 ggtgcttgta ctcaactcca tgtggtgctg atactcagac cagtacttcc ttacttactt
125641 actgtatgta tgtatgcatg tatgtattta tttaaattag atagacacgt aggtaggtag
125701 gtaggtagat acaaagacag atgaaacagg gtctcactat gttgcccagg ctggtctcaa
125761 actcctgggc tcgagcaatc ctcctgcctt ggcctcccaa agtgctgtca ttacaggtgt
125821 gagccaccat gcctggccaa tggccagtac tttactgcag aaggatattg gcatttcagt
125881 ccctgatggg agtgggaggg tggggaagga ttaaaaacaa tgccaatcca cttttcacat
125941 ttgattcaaa tttttttaaa ccttgcatta caattttatt tcctaatagc ttgttgtgac
126001 aaatttgatt tgtagcttct gtttattatc tgccacagtc tgcttttcct ctttggaata
126061 ttgacaaatt ttctagctgt tgagatattt ctttcctaat tactttgtga caaagtagtg
126121 aagcagaatc cgcttctaag acatagcctg gtgtgaagta attagcttac caagtagcct
126181 gatctttcct cgtgtgaatt cactcaacta ccgaaataac agccagtgtc actattgcat
126241 attgaaagaa acccttaatg tgattctttt tttctttgtt gtaaatcagc aagaatttat
126301 gctcttattt ttatcattcc tgccaaccaa ggagataaat atttcgtaaa atcatgttgg
126361 gtgcacatca ttataagatc ttgcctattt ctaacaatag ttaaatgatg tatttcctta
126421 gttaatgtcc ctatacatta gaaactacac tagtaacata gttaagactt acatattgtg
126481 atagtgatgg ttattgtgga aaattactat gctataacat gaagtgttca gageacatac
126541 ccttcagcca gactgctgag agttcaagtc cctgctcttc catttatcag ctgtatgacc
126601 ttgagtaagt tgccctgttc tcagtttcat cacatgtgaa atggggataa tagaagtact
126661 gggttgtcca tataaagaac tgaaagtact acctcagcat gatgaatgcc atatgtggtc
126721 tatcagagct agctgatttt gttgttatat ttaacaagca cagaaaaRct gatgggaaac
126781 actgattact atggctatag gaaatattct gatatattct ttttgtttct tcttagcttt
126841 tcctaagccc aaatgggact gtcaattatt tgattcttat tctgagtcac tgccggcaaa
126901 tcaacaacct cgtgacttga atcggatgga ggtaaaagat cttcatatgc taataaataa
126961 ggatgtgtat ggagctaaat ccattggcct atgttcttta caaattctgg aaaatgaact
127021 ttttttttgt ttgaaaatga gcttttataa catttccttt tcatacttgg taattattaa
127081 tactttgatg ctcagccttt cagatctaga caccagatgt atctataatt tttttccctt
127141 ttctccctaa aactggatgt ggtaaagtaa gtaacataat ctctagacct tctagatgtg
127201 aaatgtagat atagccaaac taagacagaa aattctagcc aagttattta ctttaaccaa
127261 gctttaattc cctagtaaac aattttgatt Statttttat cagttgggca ttaataagct
127321 atactgaatc agaactgttt tgagaagagg tttgagaact ttatWtgagg gccccaaatc
127381 acattcggaa ctccctcagg gtttttagct tttgaaccaa atgaggactg atttggatga
127441 tccccagaag gaacttggag aattccccca gtgttgggcc atggatggaa gggcttagcc
127501 aagtgcttag gaagccttag ctatggatca ataaatagga gttgttatag ttattgttgt
127561 catcaccatt gtcattatca tcatcatcac cattatgatt actgtgatga caatttagga
127621 tacctgcttt tcccttcctt aaaagatctg gaaatgttta ataaatggag ctttattcac
127681 agactccata atagtcagag actattagag tcctctgacc ctagttgaaa ccactgcaag
127741 atgatagaag tcaaagtcag ggaacaggga catttcttta atttcttgtg actgtgcatg
127801 atgatttatt ctctcacatg aggccctcat gcctgtagca tgtgttatgg atggcaccgt
127861 ctgctcccct gtgagccagt caagcctgcc tttccagtgc ccctctgact aacatctctc
127921 tgccattttg cttctctttc tttgagttgt gtcctccatg gtactttcct cagatttcta
127981 ctcatgggaa aaagacataa agaaaagtca cttcaggagg aatgacagat gtgcatttga
128041 agaattttgg ttaaaatttt ttttttctgc agaatgctta tgacaaagag agagataaaa
128101 tagtttgcca cttttcatgg ccctcagttt actttggggc ttctagcagt gtttaaagag
128161 ctttgtttat caagccagga tggatacatc tatggctctc tgactatgtg tgtgtgtgtg
128221 tgtgatgggc cccctgcttg cataaaatga tgaagttatt agttggtctt ctttaaaacg
128281 gccataaaat ctgttacaca tgcacacgtc tgttttactg ttacacacac acacacacac
128341 acacacacac agtctctctc gcttgctctt tctctctctc taatgtcctg gatggcgtta
128401 catatattca cctttgtgga ttttatatgc agctagtttt atatactttt gcatacttta
128461 agtggcctcc ttggggaggg gagattaaaa actacctagt cttttttttt tttttgccct
128521 atccaaagaa gaaagcaaaa caacaacaaa aaatcccctc ttttccaacc aaattgttat
128581 ttttgaggat gctatggttt tagacaatga atgcagtaaa cagaattcaa ggacaaagta
128641 atagggttta ttgatggttt gttcatttaa gaagtacggg tcagattgca ataatgattc
128701 aatatttcat gttcttctaa actattactg attgttcttt ctactagtct tttaatctat
128761 catgaatgca tggagtttaa ttagattttg gaaccagccc tgtgatcgat gactccagta
128821 taggtggttg tgttctgaac aaagctgcag ctgatttagg tctcaSgtca tgagaaattg
128881 gcttagtgat acatcttttt ctaaagacag cagagctgtt agccatgtac ttatttccat
128941 taagaattac agatgataat ttcaagtata tttcttttta tgagtgtctc ttacattact
129001 ggatttcttt ctttttctaa acagctttat tgatagagac tttacatacc atacccattt
129061 aaagtataca attcagtaat ttttattata ttaacagttg ttccaccatc tctacagttt
129121 aattttagaa gaacatcatc agcccaaaga gaaacccaat actcatgagc agtcacttcc
129181 tattccactg tctctgccag cctctgataa tcactagtct attttctgtc tctagatttg
129241 cctattctgg acatttcata taaatggaag catatagtat gtagtgtttt gtgaccgtat
129301 tctttcactt agtataatgt tttcaaggtt cactcagatc ataacatgta tcagtgcttc
129361 attccttttt aatgctgaat aatattgcat tgtatggata tgctacattt tgtttgtcca
129421 ttcatcagtt gatggacatt tgcattgctt ccacttttgg ctattgtaaa taatgctgct
129481 atgaacatag atgtacaagt ttttgtgtgg gtgtgtgttt tcggttctct cgagtgtata
129541 cctaggagtg gagttgttgg attgtatcat aacttaactt tctgaggaac caccaaactg
129601 ctttccaaag caactatact attttacatt cttccactag cagtgtatga gggttccaat
129661 tttcccacat ccttgttaac acttattgtc tgcctttttg attttagaca ccctagtgga
129721 atgaagtggt atctcattgt ggttttgatt tgagtttcct aatgattaat gacgttgagc
129781 atctttttgt gtgcttatta gccatttgta tatcttcttt cgccaagtgt ctcgtccttt
129841 gtccatttta aaattgcatt acttgtctat tgaattgtaa gtgttcttgt gcttttggca
129901 tcatatctaa gaaaccattg cctaatatta aatcacgaag atgtacttcc atgttttctt
129961 ctaagagttt tgtttgtttg tttttttgtt ttgttttgtt ttttgagacg gaatctcgct
130021 ctgtcaccag gccagagtgc agtggcgtga tctcagctca ttgcaacctc tgcctcccgg
130081 gttcaagcaa ttctcctgcc tcagcctcct gagtagctgg gactacaggt gcgtgccacc
130141 aagcccagat aatttttcta tttttagtgg agacggggtt tcaccatgtt ggccaggatg
130201 gtcttgatct cttgacattg tgatccaccc acctcggcct cccatagtgc tgggattaca
130261 ggcgtgaacc actgagcctg gcctcttctg agagttttat agttttagac ctttacattt
130321 aggtgtgtga ttttgagtta atttttgtgt atgttctgag gaagaggtcc aactttattt
130381 ttttgtatgt ggatttctag tcgtcccagc accatttatt gaaaagatgt ttttttcccc
130441 attgaattgt cttgcaccct tgttggaaat caactgacca tagatgtaag ggtttatttc
130501 tgggttttca gttctattct attgatctat atgtttatga ttatgccagt accacagtgt
130561 cttgataatt ttagatttgt agtaagtttt gaaatcaaga agtgtgaatc ctttaacttt
130621 tttcttcttt ttcaagaata ttttgctatt ctgacttcct tgcatttcca tatgaaattt
130681 aggacaagct tgccaaattc tgacaaagat tgcattgaat ttgtagatca gtttggagag
130741 tatggccacc ttaccaatat taagtcttct aactcatgaa catgagatgt ctttccattt
130801 atttagatat ttaatttctt tcaacaattt tttgagattt ctttttatct acattgccta
130861 cttctaaatt atgttattct ccaaaggggc ctgatttata atgcaggtgg gaaaagacaa
130921 tgaaagaaat gcactgttat gatacattgt ctgttctatt ggagatagta gactttgaat
130981 agaaaattat atctggatac ttcgttttaa tgagtaaatc ccagcactat gtgaggccga
131041 ggtgggcaga tcacgaggtc aggagattga gaccatcctg gctaacacgg tgaaaccctg
131101 tctttgttaa aaatacaaaa aattagccgg gcgtggtggc atatgcctgt agtcccagct
131161 actcaggagg ctgaggcagg agaatcactt gaacctggga ggtggaggtt gcagtgagcc
131221 aagattgtgc cactgcactc cagcctgggc aacagagcag gactccatct caaaaaaaag
131281 aattacctga gtgaagactg ttaaatctta gaccagtttt ctactgagta atacttcagt
131341 ctctttcttc agaacagttt aaaaacaaaa gtattgctta tctctctggg gttgtttagg
131401 ttctgagagg taaaccaatt aactttttgg aacaccagat ggctccaggc atttactctc
131461 cttccttcaa gataaatgtt acaatttatc tttatttaat ttgtgactat gttttaaata
131521 taaacaatat caaaagacat atgttgacaa gtcttcctcc catctaccaa ctcacctttc
131581 aattcttaca tatctttcca gagtttgtgt atataaataa agcaaatgtg aatatatatt
131641 attcttgaac ttaatcttat aggcattaga gtgcatattc ttttccagct ttgaggtata
131701 attgacaaaa aatatatatt tatgatgttt tcatctatgt atatattgtg aaatgattac
131761 tgcaatcaag ctagttaaca tacctgtcac ctctcacata gttacctttt tttggtgtgg
131821 tgagaacatt taacatcaac tcccttagca gttttcaagt ataccataca ttgttattaa
131881 ctatagttag aatgtgtgtt aaattgagaa tttacaagaa gtaaatttac agtaagtaga
131941 ttttaaacgg tttaaaacta attcatactt gatagatttg ggtattcata ttagtgtgag
132001 gacttccccc ctgtttgcat taggagaaaa ttttaatctg ctcatcagta aaattctttt
132061 atcccacaac aagaaggctg gtttaatcag gtttagacac catctgcatg acagatcttg
132121 gcaaacaccc acattgtggg gccacttgtc agaacttctt tgtgtttgtg aaaaaataca
132181 taaagaacag gtttgttctt ggccaaatgg accagagttg ctatgcaatt ctgtggctga
132241 atcccagtct gaattcagat ttaatacatg tgccttaatc tgaatcattt ttttcctctg
132301 tgtatgtaaa atttcaatac aaattaacat atacctcact aggaacctaa aaaaaataag
132361 gtagtattaa atgcagggtt tactgcagat ggaaatggtg gcaagaaata atagctttta
132421 agacattttc ggctgggcgc ggtggctcac gcctataatc ttagcacttt gggaggctga
132481 ggcgggtgga tcacgaggtc aggagatgga gaccatcctg gctaacacag tgaaagccct
132541 tctctactaa aaaatacaaa aaattagcca ggcgtggtgg cgggtgcctg tagtcccagc
132601 tactcgggag gctgaggcag gagaatggtg tgaacccggg aggtggagct tgcagtgagc
132661 cgagatcgcg ccactgcact ccagcctggg cgacagtgcg agactctgtc tcaaaaaaaa
132721 aaaatttttt ttcatcatat gtgcgcatca cttaatttct gttccaacca gtttaattca
132781 tttacttttc tttttcaaag aagacatctg ttaaagacat ggctgacctt cctgtcccta
132841 accaggatgt aactagtgat gacaaacaag gtaggagaag aatgagtttt cttctttaac
132901 cagcgttcta cctgttacct tatctactcc tcttggaatg gtggcttcta gagcatatga
132961 gggtggttct cagcatgtaa acacatttgg atagactaag tagttcaaat cattgtcata
133021 aaacaatagt tcacaaagtg gtagcaagag cttgagtgtc cagagtcttc caactcattg
133081 gccccttagt cattgctgac cctcagccta ctcttaacac cttacactgg aatctgatcg
133141 tagcaattag gaaatgacag gaagctgaac Raattgagaa catgttgtgt ttgcggatgt
133201 gatcccagac atcagtgtaa atgcacattt gcatacagct ctaatccatg aggaagttct
133261 cttctggaca cagcttctgt ccttagtgtt tatctgtttc ttggctttgt gagtgtggga
133321 gtgtgacatg gagcccagct acaattttcc tatcttactg ggcagctgag aagcagtgca
133381 gcacagcatt ccgtgttaga gctactccca gggaagagtt ggcttgggaa tatctagaag
133441 tgtgggaggg accctctccc ccacctccta tactttgtat agtgctttat aatctaccag
133501 gtccttgctc atatactgtc ttattcagtc ctcacaaaac tgaatggagg ctggtaagtt
133561 ttatcacctg aaatttagag atgagtaaac tgaaattcag acactatgaa tcatttgcct
133621 agttattaag aaaaagattt gggacaagaa ccaagatttt ttctaagcct caagccagta
133681 ttctgcctgt tatttgatat tgatttacta cccatgaatg agaggcttat ttgaagggac
133741 taaaaatcag tgaagctatt tcaggtttta ttgttaaggc ctgccattga ttaggcattg
133801 tatgggggct taacatgaaa aataagtttt ccattaagtg acagtaattg catgttctct
133861 atttaaatac ttgcttggga gagacaggta gaactggaca ttgtctgcag tagcgtgtac
133921 tctgaccatt ctcctaactg cacagtggaa taactgggca aactgtaaaa atattgaagc
133981 ctggatttca ctcccaggga ttctcatgtc atcagtctgg gtgtcaggaa tgaaagaggg
134041 agaaactccc aatacttcct ggtaatactt ctcctatctg cttgaggtgc tgtctctgga
134101 aagttgaaaa tacatctttg ctctttgtag aaggagaacc tatttccata ctccaggagg
134161 tctttattgt tttagtaaat gctatagcaa cttttagagg tttgtgagac ctgtttttgt
134221 aagtgatgac tagcgattct ttgtttgaat ccaatttgcc tcagaaataa cattttatag
134281 ttttaatttt ttttcctctt ttctctttct ttttgcttaa aaaacaaaac acaactagct
134341 ttgaaaagta ctatcaatga agccttacca aaggacgtgt ctgaggatcc aggtaggaga
134401 aaaccatttt tgtatacttt atatataatt attttaaaat aaaaaaacag caagtcagtg
134461 agtagaagat tgatacctct gtgatagtgt gtctgtttct ctctatttat ttgtcttgta
134521 ttttattaca aggaaacctt ttggcttttt accctttctc tcttttcagg tatgagaacg
134581 gggtgatatc ttttcaagtt tttaagtttc actgaaagga tcacgaagga tcactccgtg
134641 tgaatatagg gtcttgttac taagtgcaaa attgagaagg cttgaggttg agatgatttc
134701 aacaagccat tttgggtttt gtgtagagta aggaacttat agggtagatc aattggaggc
134761 ccagagttgg tattttccat ttccaaagca gaaatctcaa atatttttat tatgcttcac
134821 caccaggaag gcaactatat gtgcttatat atggagtgga ttccaaggag aaaaataaaa
134881 gttgtccagt tttttggaga gtcagacctg tgtctgtgga gtcatggaga atggctgccc
134941 ctgtgtccgc agctctctgt tgatggagcc atcattgaac caagttgaat ctagttaaaa
135001 acaaagtggc tacagaagac attactattt ggagctctag ttataaggac atgaaaaaag
135061 ttgttgcttt ctcttttgct gttttatttc ttgtatattt ttaataagtc aatcatgttt
135121 gttgtgataa gctagctatc atcctaggct tatttgttga acattggaac agaggaatca
135181 atataatgtt gaggcttatg ctgtggtaca atattttcca aatgtcaagt tcattcagag
135241 tttcaaagag agatgggtgg agggagagga aggagttggg ggagtgggag aaaaatatgg
135301 tagggggaag gagagagaga gagaacatga gaatgagaat aaatatgaat gaatgtggat
135361 gatgaatttc aattatggaa gcctgagaag gtgtattttt aggcagctcc ccagttggtt
135421 ctggtacata gcctattttg ggaaccacca gctctggaag gtgatgctac aaaatagaaa
135481 attaaggtta tagatcaacc atgactccaa aagtgatggg aattcccaag cttaattttg
135541 actcttgaaa cagatttgaa ttcattcctt attgggtgaa atgctctgtt aatgtaggcc
135601 aacgcctggg gtcagttctt tctagctctt atttctggag ctaaagtgga tgcattccag
135661 tttttgtaaa cttcatgttg tagtattagt aaaagctgtt taaatttgga gtgttaaatt
135721 ggtgcttctc caacagcctt tgaggatcat aacttttcct actttttttt ttttttttaa
135781 gggattttag cacaagatca agtgtcctct ggggcatgag ctttagatct catttttaac
135841 attccttcat tgactaggac atggcatcac caaataaaac ttgtcaggtg tgccacagca
135901 tgagaagtat gtcggaattg atttctcgtt gtgcctggca gcatgctatg tgttttctga
135961 tttgttcttc ccactactgc ccctctctgg gtatgaggga gttcctcatc ttaaacatag
136021 ttaatccctc cttttctggg aaatgtttgg attcccagtg ggagacacaa gcgtttcaag
136081 gtggtgattt agaattctgg atggctgtcc ttgccatgtg gacctcagtt cagttgctgc
136141 tttttggagg gttaatctct aggcctgctc ctctttccat tcccatttcc tggaaagatg
136201 acatgccttg agtgttctag gaaggtggca gtccttttcc ctctttccag ctacacgaga
136261 agctatgatc cacttgttgt aattgctgag agtgtctatg ttagtggagc cttaagagat
136321 tttttaaacc aatatcccat tccaacctaa ttcagcagag caccatgcac aatgRtggtc
136381 tttttcttga tgtttctggc ccatgttgag gtgttttcag ctggttcacc ctcacagtgc
136441 tgtctttaga ctgttgttgg tgattctagc agctgctcca ttgccaacta tcaccccatg
136501 tttttattgg agtagagcag ttctgtcctt Scattacctg ctcctacctg cacctccttt
136561 gctgtcctag aagaaactaa atttagaaac cagatttcca ggcttaaaaa attaggagcc
136621 tttatttatg cactctacaa tagtaatatt ttgcaattct aaagtacgtt cagtttttaa
136681 attactttca ccttatctgt ccctgtgaga aagaaactgc atttttattg cctttgtttt
136741 ctaggtgagg agactgaggt tcagggaagt aacagctagt tagtgtcatg gccaggagga
136801 gggccttagt ctcaggactc ctggcctggt ctctagtcct gtctctccac tactcatcca
136861 caccctcacc ccatctgtct gtctgtctat ctctYaccag cagggctcac ccctccttcc
136921 acacccatcc ctaccagcaa aaagacaaag ataatggcac ttgacaaagg aattaacagt
136981 caccatggtc tgatttgggg aacagtattt tatcatggcg gggacctctc ctacccatgt
137041 atttcttgaa agcagtgggg cctgagggag aagagggcca cggagccagc tgcaggcagc
137101 ctgcgtagag ggcttcccca gctctgtggt gagtctggtc cactctgtcc acccagcccc
137161 aaggcagcct cctgagctgg gagagaggct tcctgaggtc gctttctttg ctgcctgggg
137221 tttgtaggag ggagggaggt ctttttctgt ctatatccag gtgtgggtgc acgataatgg
137281 gcaaaagggg actcaaactc cttgggcttt ccaggctttc ctgcactctg gcagcgtttc
137341 agctgtttga agttggaaga tctctgtgtt ctcactacaa caagccaaaa tgcttgggtt
137401 gggagaagtg tatctcttgt gcagctgacc agtagtttgc tttgtgcctt gttagcattt
137461 atgaggattt tcacctcccc tctctgtcct gttatctaac ccaaggattt taatgatcat
137521 cataaattca ggctgcttca taccaaggag ggtttttatc tttggagcaa tgtaaaagag
137581 gatgagataa tgcagtgaga cattttcttt ttggaagaat tcatgcagac aaagaaatta
137641 cattcttctt gttctgtgtt actagcacct tttctatgat tttttatgac attttatgat
137701 gaaaaatttg caatgtttgt aacacctgag catagctact ggttcctaaa gttgtcttcc
137761 atagaggatt gaaagcataa aaagaggatc agtgtttttg taaatgtttc taattactcc
137821 tcacaacttg tgatggggaa gaaggctgta tgggcgttgg tagtgagcaa gttagtttat
137881 gatttaaatt tgatgaggaa aagtcatatg gctgggaaaa gattcagcga tattgttcat
137941 aattctctgt atgatttggt cacagacatg tgggacacaa ggatattttc ttacaggaga
138001 agctgtatag ctcatttcca cttacttgtg agagctttgt ttttttgtgg ccatgctgct
138061 ctggtagtgt attttttttt ttttaaaacg tgtagttaga tagacttctt cctatccttc
138121 agggtagact agttcaaaat ctattactag actatcatga tagaacaaga aaccctgaag
138181 tgtgaatcca tcattatata aaaagacaac cccctttcaa gggggttgtc tttttatact
138241 ggaatgtctt cattaattaa cttggatttg agaatggcct ctcaaatagt gcttgaccaa
138301 aggaaaaata tgctggtttt tctttccttt taatcgtttc tttagatttt gaaataaaac
138361 aaggaaatca tgaaaatgtg ggagccgtcc agttctccac atgggcactt ttacctcaca
138421 tttacctKtt gatgtgttct gtactagccc aggtgctgca tataaacttg tttaactgca
138481 gaaatgaaac ccaagcaata tctttgtttc agcaactccc aaggattcca acagtctcaa
138541 agcaagacca agatccaggt agtgttcgtt taatttctgc tttaatgccc tttgtgccgt
138601 gcccctgcct agaaataaga accacaaacc aaaacccaac ccatgatttc ctcttccttt
138661 agatgtaaag cttaggatat gagccatttc gctcgtgcat ggcctgatgg gaacatgcag
138721 taatgctggg agccttggtt tctgtggtca ttagtgctag aaggtgacca tgaatgccct
138781 acggcccctc aacgtgaagt ggattgtgtg agacaaccca gttgttgcaa gatgataact
138841 tataggggga agtagctttg gaaagaggaa aatatgggta aggtaacaga cacgaaaatt
138901 tgctatcatg acaaggtgaa caccaaaaag taaaaagtct gggtaataaa atctacagta
138961 gggaaagaaa atgcttctga taacttcagt gaagcttgca gtttcaggta agcgatgttt
139021 atggtctgtt tgagcctatc ttagtgcccc tStaagcttc acatttttta agaggctagt
139081 acaagagaga aagccagtaa ggcagagctg tggttgatgt gagactcaga agagaggtgc
139141 agaggggaaa tacagagaca ctaatagaat taatccatta aggaagggaa atggtattgg
139201 tactgtattt cactggtaga actgcagtgt aagataggat aacgaggata ccatRtgtgt
139261 gttttctgtt ttgctttggc tgttagtgac atttttccct cctttgccta ctagacacaa
139321 tcctgaaaaa gtaaatttaa gtctgatcat attttatatg cttgaaatac tgatatttaa
139381 ggaacctcat ctctttgtaa gtcaaagagt tatcctttag tttatatgtg cattttccaa
139441 attggggttt tgtttccttg tttatgtaag atacagatat ctatattttt atatttatgt
139501 gtatttaaaa acaatagagt aattcattta ggtaggaaga aaaggtgtag gcattctttc
139561 tgtggtcaac acatttactc atcctttgta aaaggatgaa tggatctttt acaaactagt
139621 ctgtactagt tgtgggatat gctttcatag taggaattgc ctttgaattg cagaaatctg
139681 ttatgtgtac tatgttaacc ataaatcgaa cctcaaagtt ttagcttctg ctgacttcct
139741 ctctccctga aagccagtga aattataaaa tctcatagcc acacgttctg ttattaatgt
139801 gtctggctaa attttacata ttatcctttc agagattgcg cttttggtct aatttggagg
139861 attttatttt cattacttct cactgggaag aagagaattg aattgttttt atcctccttt
139921 ttgaaataat aaagttttgt agaaatataa gggaaagagg gaaaatcacc attttaacac
139981 cactgcattc atcattttgt taactccctg cacatttatg ttttaattgg ttgcagcagt
140041 catggttata caatctcact tattttatat tcagtaactt tccatatgaa gatataaaca
140101 tacaggttat atatgaaaat aaaatgaaaa tgaggaatgt gcgctgtggg attgtgtgct
140161 taacagtgtg cacgcataca cattatttac acacacatta tttctttttt gagtgaaaga
140221 tgtcactaaa gctatatgtg gcatagaaag ctcttttcat ttctagctag ggtctctaat
140281 tgtctttttt aagtgaagtg ttcccattta agaaccttgt ccttccgtat cagttccctt
140341 tgattcttgt tgaaagagcc agagcattct tccctgctag tttctgcctg ttgctgcctt
140401 gcctgtcttg ccagttatgt tacagggacc accccagaac acgtcacatg ccattatggt
140461 ggctttatta aagttacaac cttgtaagac agacagaacc ctcaactacc acaaagaatc
140521 cttgagaaat ttattcagga aaataaaaac tcacaatgtc aaaaacagct ctgtcaagaa
140581 ctgaaggggt ttaatagtaa ctgatatatt Staacttcat aaatgccact ctaatagcta
140641 agtacgaaga aggttttcag aggttaattt gtctctctag gatgtacctc tgactcagag
140701 gtcgttttct gctttgacat gaagctagtt gagaagctaa ataaaacaga tgtatacatc
140761 tacatcttag ggccttttcg tgatcatcgt attgggaacc cgtccttaaa cctattccta
140821 agcagtgtat ggagttgaat tttatttgga aagtaagtag gtctccaata aatattctag
140881 ttgctatcac caaagtattc ccccgccaac tcataggcag tatgagaaca ttttaaaaat
140941 gggatataga aacagagatt ggagtttgaa tcgaactgtg taactttcta tctgaccttt
141001 tgcaagttat ttagttcctt tttaaaaaga tgatattacc agagttacaa tctcagaagt
141061 tgcctagtta attatgcctt gctatagatt gaggaagaag gttgaaaatg agacttttgc
141121 tttctcaggg aaagacaagc tagacccctc aatctgattg atgtgtgttt tcctttccca
141181 gcttcgtttg tggcatattc ccctgaacat tgaattctta ccctcagctt atctgtccca
141241 attccacatg agcctgtcat cacatttgca agtgaacagg agaaaagttc tctgatcagt
141301 ttataccatg aaataccatg aagcccttct gttagaacat ggaaatgcct aagctgaggg
141361 gctccatatt attcttatta acaattccaa tagaaatgga tttgaattta cacaaagttt
141421 tttttggggg gttgattcag atctaaggta taataagaac aaagaggttg aaaagatccc
141481 aattcatagt tggatttgga caattattgt acatagtggc attcaatggg taatagaatt
141541 tatggctgct ttggtagctc atcggttctt tgtagtcact ttgacttcgt gggtattttc
141601 catttcaccc caacttcaga gagtaaagct ttgctatttc gcttctgacc ttcccttatt
141661 ttgctacaga tcttactcta gcacctccat agaagaggcc atgaaaaggg gcgaggaccc
141721 tcccaccccg ccacctcggc cacagaaaac ccattccaga gcctcctcct tggatctgaa
141781 taaagtcttc cagcccagtg tgccaggtga agtgcccctt gccccctgag cccttccatt
141841 tcctgttgga gccagcggat gtgtgtctgc cacagtggcc tctgtgagtc cggagaaaga
141901 gcagacctgg cagtttcgca ttccgtgaag gtcttcacgt ggctatggta ttcttgggag
141961 agaaagcaat tctagacaca tatgtagcac atgtgtctgg agccttgccc acacttgtta
142021 tggatcaaga attaggaaat tctctaccaa gaggataaaa atgcttcact cccatgcagc
142081 ctgctgagtg tgtggctggg gtcttactct ctgcatcatt ggtaatttgt gaacaagata
142141 gatSgctgtc tgtcatttcc tcagatgcct gtgtggtctt ctatgaaaga tcttggagat
142201 taaggcctag ccagaacctt ctcctgcatt ttacacttat ggagaagatc ctgtgtcctg
142261 taggatttaa tgctgagggg actctgaatc tgactgatgg ttgggtggtt ggtggagggt
142321 cctagggcaa gggctccttc aggtgggctg ctctgggctt ctggggatgg gatgttcttg
142381 agcccgcagt tgtgtagtgg ggctggaggt gggggaggcc cagaggggcc ctgtctgctc
142441 ccttggcttc ctgtgaagta gaagataccc tcctaaggaa cctaaggaat agaagatggg
142501 aggcatgcct ttgctttagt gaaggtgata ggatacggtg ctgtcccaag tgttattttg
142561 ggagcagcaa gggcctttcc actgactcat gcaggcaagc tataaataca atgatttcct
142621 ggaacttttt ctccatctat gtgcatttta aatcaggcca gcctcagatg ctagtgattt
142681 gcagattatt atcttttctg ctaaagcaag aaaagacttt ccttggctca cacattagca
142741 tgacctctgt gtctgggcag agctcagcat gttttatttg ttctaataaa gtattctcct
142801 cacagtaaag ttatagattg ttttttaata tactaaaatc tggaactctc tatcaaattt
142861 aattctgtgc catgagttca tcagacaaaa atttgccttg aatttcctct catactttga
142921 tctgaattct ggcataaatt tcatagtgac tggtatgtag ggtgggagta accacaggtg
142981 atgatgctat aaaaatttca catggctggc ggattatgac ctggaagatt ttcctatgga
143041 tgcgagaaaa ttaaaacaat ctgggaagct atctcagtac ctttaccttg caagaaggga
143101 ggctggaaat gctcacaggt ctctctcagg ttgtgtgacc cagtaaggag atgccagctg
143161 tactggagaa ttcacatgct gtggttttta cgacactgca tcacatagtg gaagagacaa
143221 aactgggttt ggagctcagc tcagctgctt attcactgtt tgattttcag caagtagctt
143281 aatgtttatg catctcagat tcctaatctg tacagtagag ccaatactcc atggagttgt
143341 aaggttttgg tgagataata aacataatcc aaatatgggt tgaatattcc ttatccaaaa
143401 tacttggggt cacaagtgtt tcaggctttg gatatttttg gattttggaa tatttgcatt
143461 atatgcttac caattgagca tataataaaa aaatctgaaa tgcttcaatg accatttcct
143521 ttgagtgtca tgttggcact aaaaagttta gggttttata gcattttgga ttttggattt
143581 ttgggattag ggatactcaa cctgtagtac tgtatttggc ccacaggcct tagtaagcat
143641 gtaaggccca tattcccgtg gcctgcaagt atcaagaatt taatgcctga aatggcaagc
143701 ctccaccgag gaggataaca ccccgacttc cttgacccct agcagacaat tctgtgattc
143761 ctcctaccca gtttctcaga aggctcgcaa aaggactgaa ccccagttgc ctgccgtagt
143821 acaccattca ttgatgtact ttttcttgtt ttgcttccct cctgccctgt ctcactttcc
143881 cctcactcga ataatatacc tgttctcaag ttcatatgtc aggggcttct ttagagaaaa
143941 cctgaattaa gacagctttc tttgatatct ctgtgtcaat gtgacttcaa gatgaaaagt
144001 attttggttt gataatgccc tgacgatctc ccttgtggta gggcctgata aatctaagat
144061 ttagacaaat aatagctagg tgggtgatgt ctctgttcat agcctaattc cattgtcttt
144121 tcagtacaaa tttatacaga tgaaatttta atgagcagtt taaatttatc acatgaagaa
144181 tagaacattt ctgcagtatg aaaagcaggt ggtataattg catctacttt atttattttc
144241 atgttggtta attctcacag aaaagtataa gggtctgtct aaattatata aaattttagt
144301 gtattgcata ttgctagaaa ttatcgaaat gctgacaaac tagaaatgca tgaaatagag
144361 cttaaaccta ccagaagagt ctactcactg agaatcatgg tgtacattta ggcatccctt
144421 tgctgcactt atctttatgt atcactttag ataaatggga tcacactatg cttgctgttc
144481 tgtatcctga tctttccaat taaccatctt tctatttcat atagaggatt gcaccgttcc
144541 ctttaaggtg tgcatgatat ggatatacca tggttgactg tgctttgatg gagagatctc
144601 tcccttcttc tctctgcctt ttctcttccc catactttcc tcttaagctc acccaccacc
144661 ccacgacccc agcccccgtt cctttctcac ccttgcaaac aaacctctct ctctctccac
144721 cccgaccccY gtgtcctctt catacccctc tgtttctctt tttgtccttc tcccccatca
144781 ctccttcaca ggtatgagcc tcccctcact ctccccttgc caagctcccc cacaccacca
144841 ccttgttctt ataatataaa cgaggcagag gttattaata atttcatgtc cgtatctttg
144901 tttcatcatc taattatttt cttaggttaa atcctgctgg ttggagttgc agggtcaaag
144961 gctgtagatg tttaaagtgt agctatatgt tgccaaaggg tgaggtggaa cacctgtcaa
145021 cttgctccat catcaacact gtctgaaagt gtttcctcac aatcttgcca acactgcttc
145081 atgttcatct ttttaatcat tacctgtgta ataggcagtt tcatgtccct gattcctagt
145141 gaggctgaga atctttttgt attgttattg gccataaata ttccttctct tatgatttgc
145201 ctgctcagaa ggcttggcca gcttctgttg ctacatctct ctttgcctaa ccacggggac
145261 cacttctttc ttcttcattt tgcctacgtt ctggacctcc ctcctgtcag gcacttggga
145321 atgtgagggt ggccatgggg aagcctacct cacctgctgc tgtgctgttc cttgtccctc
145381 cagccccgcc ccccatatcc cctccttctg ccaactttat cacttaagac agactgcctg
145441 ggtcaccctg tttatgacaa tagaagaata aggaaaggta aagaaaagag gggaaaataa
145501 tgtgagatga agcaagatgt ggacttgagt tgaaagggaa agataaaatg aagcccttgt
145561 ttaataaaat gagactcagg attgtgaaaa gcagtgattg aagctaaggt gctgatacag
145621 agtggcttaa agtggagtga tagtgtggaa aggaaatagg atggagagaa gatgcaaaga
145681 aaaatgaaag gaaaatgaag ggaaagatgg gatggttgtt acataggagt gatgatgttt
145741 atccaaagga ataagcagga aatagaataa aaaattgtag aaccaatgga aggagagtcc
145801 acagactctt ggtgtaggat tcaagcagca tttaaaggaa tagcttagaa gtaggtggca
145861 ttaatgcctt tacatttatg aaaataggta acatgatatg gggaaaaaga acaaagggct
145921 gatttagaat gtaaatctat aaaaatgaat aaggccaact ttggaaatat agaacagttg
145981 gcttcaactt tggtgtctgt aaagagagtg tgaatgtgtg atttatagta gcctagatga
146041 ttccagggct ctctaggtac tggcatcaga cccgaggcat gtgttttcat aaggagaagc
146101 ggatacacta tgatcgctgt gtgtaacagg gagatcacca tttgtaatag ctgacccagt
146161 tcttggagcc attgcctcac agtcccacac agctgctgtg tttgagagat agcaaaaatg
146221 tgcaagaaag tctaagtcag tgacaatgca agtatgcaaa acctagaggc agtcagacct
146281 ggaatttgct cagtgatgtt tggattttat gtctctatat ttatagctat gaaacatctt
146341 ttattactga gattcctgta agaaaaatca cactaagctg gtacctaacc tccttttcct
146401 caatgaaaca gttattttca tgaggtaatt tttttttcat aaaaaggggt ttcttctgtc
146461 cacggagtca gtaagaacta cccctctctt ctactcttga ttcagacctg cctcttctca
146521 aagccatgcc tgaggtttgt agcctgaggt ttccatggtg acagtaaaaa gccttagctc
146581 tgccttgttc cagtcattga gcatctgcct ggcagaaggg gcagagatgg tgtggaggag
146641 acatagccat tcctttaaag tttcagaccg ggcattttca tcatttccac tcaaatctag
146701 ctgggggacc taggcccatg gatagaccta gttgccaggc agctgggaaa tgtagtcctt
146761 ggcagggcag ccatttccca gaaatacgtt tcttactgca aaaaaggaga aggggatgtt
146821 gatggtcagt tgtttttttt taaaaccaca tcccatatgg ccaaatacat tgagattcac
146881 acattaaaac cattgtgatg gctgaacaga acacatccag ggctagtgtc tgtccatggg
146941 tagctaattt cctatctctg ctttagatat actgataata acaactcatt ccatggttaa
147001 gagactatgg tacatccatc ctatggaatt gtatgaagct gttaaaaaga acaggcacgt
147061 atactacatg gagagctatc tcggataaat taagtgacaa aagtatgatg cagaatgtgt
147121 atgtttataa atgtgtagac aatttcagga tgatgctaaa gaaactggta atgatagttg
147181 cttctgggca aggggaacag tatgactgag gacaggactg ggaaacaagc ttactttctg
147241 ttgaatgcct atttgtatct ttttaatttt ggctcatgta cagatgtcac ctattataaa
147301 aaatttgctt ttcactcttt agctgcaatg atggtatctg aaagtaccag agatgtcttt
147361 cctgcctgag gttacctatc tcaatcttcc ctacgattct gtattcaggg tatctttatg
147421 accatctgct accacctcct ggaatgcagc tgaaatgaca gaaRtgttcc gagcactttt
147481 tttttttttt tttttttttg agatgaagtc tcgttctgtc acccaggctg gagtgcagtg
147541 gcgtgatctc agctcactgc aagctccgtc tcccgggttc atgcccattc tcctgcctcg
147601 gcctcccaaa tagctgggga ctacaggcac ctgccaccac gccctgctaa ttttttgtat
147661 ttttagtaga gacggggttt caccgtgtta gccaggatgg tctcaatctc ctgacctcat
147721 gatccacccg cctcagcctc ccaaagtgct gggattacag gcatgagcca ctgcgcccag
147781 ccccgagcac tcttttaagc tctgatgcgt tcttcagatt ccatttcagt gcctttccaa
147841 cactgaggag tagttctgga ggacctccca aagattacat tgtgagatgt atagttgggt
147901 aaaacgtcat ggtaagggct ctgtcttaac ttggaagtgg ctgtgtttat tgagtggcga
147961 attgagaagt ctttcctcgg ttttctataa atgaatattt gtttctgtaa cttaagaagt
148021 aggtaaactc cttgggagta agagatgttc ctaataccaa acttaccttt caggttctct
148081 aaaagatgaa tttggccaca aaagcagctc tgaccttata tatttcctta ctgtattttt
148141 cctgtgagtg ctacttgttt cttttaaaat ctggtaggac tatgggattc ctgacccacc
148201 ccaaaccttt gggcccacag tgcacagcta tccaagggtt caatttggca gtctgggcag
148261 tttttttgtt ttgttttgtt tttttgtttt ttttaaatga aagcgttatt gagatgtaac
148321 ccatatacta taaaattcac ctttttaaag tgcacaattc agtgatattt agtatattca
148381 tagtgttata tataactatc agcactatgt aatttcagaa tattttcatc ccccYcaaaa
148441 gaaaccccat acctattagc aatcattccc attcccccct tttcttcctc tatcccttgg
148501 caaccactaa cttactttct gtttctatgg atttgcccat tccggaattc tgtattaata
148561 gaatcatata atatgtggtc ttttgtgact ggcttcattc acttagtata atgttctcaa
148621 ggttcatcca tgttgtagca tgaatcaata cttcattcct tttatggctg aataatcttt
148681 cattgtatgg ataaaccaca ttttggatat ttgggttgtt tccacttttt gactattgtg
148741 aataactctg ctatagacat tcatgtccaa gtttttgtgt aaacatattt tttctttctc
148801 ttgagtatat aggtagggct ggaatttctg gttcatatgg taactaactc tatgttgaac
148861 attttgagga gctattgaag tattttccag agcagccaaa ccaatttatt tcattagcaa
148921 tttatgagga ttccaattgt gtttcttcac gtcctcaaaa cacttgttat tgccttttta
148981 attttagcca tcctagtggg catgaagtgg tattgtgatt ttgatttgca ttttctaatg
149041 gctaatgatg ttatacatct tttcatgtac ttattggtca tatttatgtt gtctttggag
149101 aatgttcaga atctttgctc atttaaaaat tgggttgtct ttttattgtt gatttgtaaa
149161 tgttctttat atattttgca taaaagttcc tttacagata tttgatttac aaatattttc
149221 cttcgttctg tgggttgtcc tttcatcttt ttgatggtgt cctttgaatc ataaaagatt
149281 ttaattttga tgaggtctaa tttatgtatt ttgttgcttg tgcttttgct gtcatatcta
149341 aaaaaccatt gcttaactca aggtcacaaa cactcctctt ttcttctaaa agtcttatag
149401 ttttaggtct tacatttacg tcttcgttct gttttgagtt aattttttta tatggcatga
149461 gttaggagtc caaattcatt tttctgcatg tggatataca gttgtcccag taccatttgt
149521 tgaaaagact attaattatc catttaattt tcttggcacc tttgttgaaa atcaattaac
149581 cataaacata aggatttatt tctggactct cagttctgtt ctgttggtct ataggtctat
149641 ccttatgcca gtaccacagt gtcttgataa ttgtagattt atagtaagtt ttgaaattgc
149701 gaagcgtgag tcctcctgct ttattctttt tcaggattgt tttggttatt ctgagtccct
149761 tgcatttcca catgaaattt atgatcagct tgtcaatttc tgtaaaaaca aaaaagccag
149821 ctgggatttt ggtatggctt gcattgaatt tgtatatcag tttggttagt attgcggttt
149881 taataacatt aagttgtcca atgcatgaac acaggatgtt tttccattta tttagatctt
149941 taagtgtctt tcaacaatgt ttcagtatac aagtcttgca tttcttttgt taaatgtatt
150001 cctaaaagtt ttattctttt tgatatacat tatacattat ttcttggaga tatccatgtc
150061 agtactgata attttgtatt tcttttatat atcatctata tgctggctgc tctgttaaaa
150121 accgtattat gaaaaatttc aaatttatgc aaaagttgag aacctccacc cccatattat
150181 tttgaagcaa atcccaaata tcatataatt gtatatataa actctttgta tatctctcta
150241 agagataagg tcttaaaata cttgagcaca atacctttgt catacataac aaaattaaca
150301 ataattcttt aatatcattt aatatttggc cagtgttcct atttcctgaa ttgtctcaag
150361 tttgtctttt tatactagtt tgttccattc agaattcaat cgagggctac atgcacattg
150421 cacttgtttt ggcatatttt aagtctctta actgataggt tcttctctca gtcttttttt
150481 tcctctttgc ttttcattta ttcataaaaa gtcatctacc ttgtagactt tttcacattc
150541 tgtattttgc tgattgtttg ttcttccatc ccatgtattt cctataaact aataggtagg
150601 tctaggcttg attagagtta gtttagattt ttgacaagaa tactacctaa agatgctgtg
150661 tacttcttac tgcaccacat taagagatct ctagtgtcta atgcctttat ttttgtggtg
150721 tttgattgat taatgggttt acgtagtatt ggcctgatcc atgtgttatg ataaagatcc
150781 cagcgacctt tcaaataatg gttttatcag ctattgatca tcattgccta catccagtgg
150841 tgtgtcagtg aatgtttaac aaccggccac ttgccaattt ttatggtgta aacactcctg
150901 ccatggctaa tttcattcct actgatgtgt tactgaatgt ggagtttgga acagatgcac
150961 acagttggct ctcacaagct ggcatgagct ttttccagca aaccactgct tagatccatt
151021 atttcattgg tagttgcaaa atggcgatac tctatttttt ctacctttat taattgggac
151081 tatggtttat ttaagcattt tcctattgtt ggacatttaa tttgtgacta ttatgaagct
151141 tgtgagctga aggagatcat aaaacataat tctcagtaca tcagtaaatt ctttatatac
151201 atctgaattt atagaattgt atgaaaactg aaatagactt cagtaatggt gaccagaaaa
151261 gtgtcttatt caaccagtat ttaatgagca tttactgggt acttggcact ttggaggatc
151321 ccaagaggga tatggatatg cccccaaact ctgctaatca atgtcacagt tgtgtgtgat
151381 tgttagaagg gtttagagtt tgggtggttg ctaactagaa tgatcagtgg atttgtgggc
151441 agggggtgca cagggctggt gagctaaact ttgaaggata tgacttttca gtcaaatcct
151501 attctttttt gacatctgtc ttgatttact tcttatgact agtttcctgg gtgtctacta
151561 tagtagcctc aaatctggct tgcttgcttt gttctttcct tcataaagca acaggattaa
151621 ttttctgcag cacacctatg atcacttccc tactcaaaac tcttcaggac ctactatgta
151681 atcaccaaat ttctggtgga actgaacccg aagccatgtg attatattag ctcagtaagg
151741 gacacagtac tgtggcctgg agtgcctggg gaggagtgta ttacaggaag gaagtagaga
151801 ctagaagatt caagttggct ggctggccaa gaaaaatgga gactggtgga gaaggagttt
151861 gtagacggtg tctttgggaa gtcttaggag aacatcccat tagggtggta gggttaagcc
151921 agattgcaaa agattgtggc ataagcaagg aactttggtg tggagaagtt gtcatcacaa
151981 agtcattttg aaatgtcgaa ggtttagcag ttgttctgac tgtatgtcac attttaaaaa
152041 ataatggtag tggccaggtg cagtggctca tgcctgtaat ctcagcaccc tgggaggccg
152101 aggtgggtgg atcacctgag gtcaggggtt caaaaccagc ctggccaaca tggagaaacc
152161 ccatctctac taaaaataca aaaattagcc aggcgtggtg atgtgtgcct ctaatcccag
152221 ctattcggga ggcttaggct tgagcctggg aggtggaggt ttcagtgagc cgagatcgtg
152281 ccactgcact gcagcctggg caaggacaga gtgagactct gtcgatagat agatagatag
152341 atagatagat agatagatag atagatagat agatagataa agatacataa gatagataga
152401 tagaggtaga agagagccag ttccaagatg atagactgtt tttatagatt gccttcctcc
152461 taacacacat ttgtattctc tctctctccc ccaccgcatt attcagcgct aatgaaagtg
152521 tgatggaaac agctgctagt gaatgaatac taactaatcc tgaaaaaaag atgtgtactt
152581 cttgaaattt tagtttgatt tacctgaaaa catatacaga aacacaacta gtgatttcaa
152641 ccaaccctag agttttaata gtaaaatgct taggaggaat gcatttgtgt aaatgtaata
152701 tgagagagga aaccagacac ccatctttga ccaagattga atctcatgca tttttgtcac
152761 ttaagtctgc ccatgtctcc atccaggacc tagttaaccc ttattgcgta tcctatggta
152821 caggaaaaat gagttattag taaacatgga taaattttag aatcatgaag tgtcaatgct
152881 aaaagagaac ttgaatgtca tcttggccaa ctctcacata ttaccaacaa ggagactaag
152941 atccaggcaa tataatggct ttgttctcca tcagaatctt tctttccttt tttttttttt
153001 tttttaagat ggagtctctc tctgttgccc aggctggagt gcagtggcgt ggtctcggct
153061 cactgcaagc tctgcaggtt cacgctgttc tcctgcctca gcctcccgag tagctgggac
153121 tacaggtgcc caccaccacg cctggctaat tttttgtatt tttagtagag acggggtttc
153181 accatgttag ctaggatggt ctcaatctcc tgacctcgtg atccacctgc ctcggcctcc
153241 caaaatgctt ggattacagg tgtgagccac cacatcctgc ccagaatctt tcgaagttgg
153301 gaaatctttg tttagatctt tgttgcagca gatttggtat caaagaaagc tatctacatt
153361 aaattaattt ggagggcaca ccctactact tttctacggg caataacact aattaatatc
153421 taaagttaaa ggatgtatta aagaatgaat atggtaacct ttgcaaggca ctcttcaatg
153481 tgtttttttc tgtgtttcct tctatgtgat ttaaaatgtt agtagatttc tctgaggtac
153541 ttcagggaga taggaaagga gcttttgccc teatagatac ttggaaataa tatatctatt
153601 ttcttttttt aatttcaaaa atgaaattat tattaaaagc tctaaatata gcaagaatat
153661 aagacaaata gtatactgaa catccagctt caacaattaa tcaactgtgt cccatcttgt
153721 ttcatatctg tcttccccca cattattaat tatacttttt tctaccctta gcttaaaaaa
153781 aactttattg aggtatatag atcataaagt ttatccattt taagtgtaaa atttaatgat
153841 ttctagtaaa tttatcaaat agtgcaactt tcaccataat ccagttttag gtcattttca
153901 gcactccaat aatactgcac atacctgttt acagttaatc cccatgccca gccccaggca
153961 accactaacc tattttgtgt ttctgcagat tttccttttc tgaaYatttc atataaccga
154021 atatacaata tgaggtcttt tctgtctgac tttgtttact tagcatgatg tttttgaggt
154081 tcattcatgt tgtatcatgt atcagtactt aattcctttt tattgctgaa tagtattcca
154141 ttatatagct atatcacatt ttgtttatcc agtcttcagt ttgacagaca tttgagttgt
154201 ttctgctttt tgtctgttat gaataatgct gccattaata tttgaataca agtctttgtg
154261 tgaacatatg tttcatttct cttagctaga tatatagggg tggaattgct gggtatgtgg
154321 taaatttatg tttaactttt taagaaatgg acaaattgtt ttctaaagta tctgcaccat
154381 tttacattca catcagaaat gtatgagggt tactatttct ttatatcctc acccacactt
154441 attattatct ttttgattat cctacatcct agtgtgtgtg aagtgatatc tcactgtggt
154501 tttgatttgt attcccctga tgattaatga tgttgagcat cttttcatgt gcttattagt
154561 tattcctgta ttttatttga tgagatattg tgttagtctg ttttcacgct gctgataaag
154621 acatacccaa aactgggcaa tttacaaaag aaaggtttag ttggacttac agttccacgt
154681 ggccggggaa gcctcacaat catggcagaa ggctaaaggc atgtctcaca tggtggcaga
154741 caggagaaga gagcttgtac agggaaattc ccatttttaa aaccatcaga tcttgtgaga
154801 cccattcact atcacgagaa caccatggga aagacctgcc cccatggttc aatcatctcc
154861 cactgggtcc ttcccacaac acatgggaat tatgggagat acaagatgag atttgggtgg
154921 ggacacagag ccaaaccatg tcagatgtct actcaaatca tgctcattaa aaaattgggt
154981 gtttgtctta ttgttgagtt gtatattctg taattcttta tatattctgg atacaaatcc
155041 tttatcggat agatgatttg caaatatttt ccacagtctg tgacttgtct ttttgttttc
155101 ttaatgatat gttttgaagt acagaagttt tgagttttga caaagtgtaa tgttaaattt
155161 tttccttttg gattgtgctt ttgatgtcat atctgagaag tctgcctaac ccaaggtctt
155221 gaagattttt tcttgttgta aaatttttat agttttagct cttacgttaa gatcttgaat
155281 ccattttgat ttaatttttg tataaggtgt gaggtaagga tctaagttaa tctcttcgta
155341 tatgaatatc cagttatccc agcactattt gtcaaaaaat actctccttt tcctgttgcc
155401 ttggcacctt tgttgagaat cacttgtctg ttaaatataa gggcttattt ttggacactg
155461 cattctgttc tgttgattta tatgtttatt tttatgctag cactatactg aatgtttttt
155521 aacacagggg agtcatacat aatcttgcaa agaggtaatc ccacgactca gaagtcttta
155581 agtatttgct acaatggcat attttttaga tagtatatag tagcttattt acttcatttg
155641 tggtttgtag catgttcaga aggatccttt gagctccttg aggttgcagt acttctttgc
155701 tttgaagcct tctgtcatgt ttattccctg aatgtagaat accctctgtc tagctgttta
155761 tcctccatct ctgcattttt ctgctctacc tgccctgtag gttcaaaatg tggtactgat
155821 tactgctcga tagtagcctt gtgtccttgg caaggtcatt ttatttctcc aggtcttaat
155881 tttctcatct gtaaagtgaa agaatcagat tttatctcac tacttttcta aactctgtcg
155941 ttaatatttt ccttgttgaa cagttacaag gatgtgtaag ttaatctctt ttaactggtg
156001 aaaaagtata ttctgttcca tagagaatta aatgagcttg tatttcgggg ggtggtgtgt
156061 ggtcatcagg ggatagaggc aggtatttct ggaaaggtgt tcttggcaaa cattttgtta
156121 catacactgg tgtatatgac atacatgtcc atcactgtat gctgggtgat caagagatat
156181 gtataaggtc atacatgctt ttatgattag aaaggagaga aagaatgaac aatttctgtt
156241 acaaagaaat agccattttt atgaacttgc caagaagagg aatggtcctt actgatgaaa
156301 tccttaaagc tttgcatgtg gctctttact tgattgatat ttaaaagtat aggtcccact
156361 gggaggctcc tttcaacatt ttccattcct tgagtgtttt tccccccttt ggtattcgaa
156421 tgcttttatt ttcttcacat aaaatattcc tagttagggg ggatgggagc ccctttccac
156481 agctgaagtt attccaagtt ttgttccccc tgaagaatcg gctctctgtt cctgaagctt
156541 tcaatggcca catctgctgc tttatttcca ctcaataagt tggaatatat tttcatttag
156601 ttattgatta ggggctatgt aaaaatctga aggaaattag taaatagtaa tgtttatgaa
156661 taacatttta cctagaaatt tctaagcgta atgaaataag aggataaaaa ttgttagagg
156721 ttggagtttt ggatgaaggt accaggaagc agagatccaa taaatcagta tcagaatctg
156781 catgtctttc aataaactta agaaattgtt ttaaacacta ggaattatta gtctgtcttc
156841 tgaatttagg attaaatgac agtttctttt cctgaagttt ttaatgtggt tttcaggatt
156901 ggggtattta ttattttcct ttggattaca cttataaaaa tttttggctg gacaaagcct
156961 tgctgatacc tagtatccca ctttattaac tataacactt gacgaataaa cctgcaattg
157021 cttgacgaat atggtcactt tttaaagtat gtgggaacaa cattcttctc tcgtcttctt
157081 gccttctttt ccctcccagg aaagcagttg ttactattaa caagtatatt gtcatctttt
157141 gcaactgcac actagattat tcagctattt tttttctttt ttttttcctt tgccttccac
157201 catgcgatca aagtattttt taaatttcac tttgcatgaa ggtgtacttt ttcttttgac
157261 tgattagggc atactggata aaatatttgg atccaatttt aagtcaagag cagactgaaa
157321 atattgtaag agaagatttt taaaattaaa tttaattcca attttcaacc actgtgtgag
157381 tacctactaa acataaggca gtgtgtttag gtgctgtggg agacaaaaag atgaattaga
157441 cagaattgat agaatgtagc tagattaata tctcccacca ttaaaggaaa ggaacacaga
157501 attataaatg caaggaagag atttttcagc agcaaccgaa caaggaaaaa tgcatgagtt
157561 aatgctatat atatatatat atatatatat atatatataa tttttttttt ggaaagagtg
157621 gcaactgagg gaaacctgag gctttgggtg cacttctgac tctgcctgct tccttgcaga
157681 agctgtgtgt gtgagtaggc aaatcttgag agttctcatc gagaccctag gtctagagca
157741 aagtgaaatg aatgagtact cgtaattttc ctttttcttg actaagtgga aatgacttca
157801 ggaaagagag ttggaaaagt aaataatcat agctgatatc ctgatattgt agaggggaag
157861 gcccagagct tcatgctgaa ctggggacaa actgaagtct gagaagttcc tccaaggcca
157921 ttgatagaac tccaagactt aggagaatgc actctgctgc agggttttaa aatgttgatt
157981 attttggtat ttccttcgta attctaaata gcatatttgt gtaacttctt gtagacttca
158041 atttttgcca tcatcttccc tcccccaKta tctttctcct ccacccttcc aatatagtta
158101 tattataatt ttggttagat taatatttag tgtttatatt attattgtta tagccatgta
158161 agacatatag taaattactt ttttttttta cttgcacagg tttttgtttg ccttggagtg
158221 aataatcaac ttgtttcttt tcaaagtact tgcccttgat tcaaccacag acgtcttcaa
158281 ttttccagag ttcctcttat gaaattctca cacctcaggt gttctgtcag tttcagcttt
158341 ttgaagcaat agaaactgat tgtcttcaat gcctggtaca tagttttcat catgggatct
158401 ctctacactg tcatccaagg attcccttcc tctttttccc atgttggatt tcttttatta
158461 ctgtatcctg tgtctttctc tttctttgtt tactttcttg ttttggtgaa gcacatcctt
158521 cagcagcttc cttagaaagg gtgcatggag ctcaatttga gaccctgaat gtctaaaaat
158581 gtatttaatt atatcatcat gcaggctgct agtcttggat atacaatcat cagttggaaa
158641 taagttttct ttagaatttt gatggaattg tgccaatgga ttctagcttc taatgatata
158701 tgaagaagtc taaaaccatt tggacatctg atcctttgta tatgacttgc tctcttctcc
158761 tatgccctgc tgaaaacttg taaattattt tgactctagt actttgaaat atcatgatat
158821 accttgtcat gagtctgttt tcttccattg tcctggatat tcagtgagtc ctttaaattt
158881 agaaattcat attcttcatt tctgggaaat tttattgaac catttaattg attatttttc
158941 ctgctgtttt ctctgtttct ctttgtggat cttttatttg gctactaccc tattttctgg
159001 aagatttcct cagattattt ttgacctttc tattctcttt ctgctatctt ttaatttcca
159061 agtattcttt ttgttttgtt ttgttttctg aatgttcttt gtaaatagca tcccattatt
159121 tcatcttagc aaatagcatt tcttatgtct tactgagact ttctctggtg actctagtta
159181 aaatttcatc tgtcactctc taccccattg tctcttttct cagtagaata tgagcttcat
159241 aagggtatag cttttttttt ccctgttttt cccatggata ttttcccaat accttgaaca
159301 atacctccca catagttagt gtttaaatgt ttctggaata aacttaatga tcattctgat
159361 gatattaata atatatattt taacgttttc tcctagtaaa ggtctagtct gtttctttga
159421 ggtcatttct tcctgttttt attgatccct accttaggtt agaacatttt ctgcagatat
159481 ctggtaatac ttagtcatcc acttatattt aataatgaag gataaaaagt tgcttggaat
159541 atatgagcaa attgatggaa gttgccagct attggcttca tggtagaatg gtctggccag
159601 gccatcctgt tggagatccc ttgatatcaa ctctttagat gtctcttcct ggctgatctg
159661 attctctgga acacattctc ctaatctcta gaaggaagca gcagtctggg agcagaaggg
159721 aagaaggctg gaagaatctc agcatccaaa gtgcatattt ttactgaatc tgtctgtttt
159781 cagcatggcc ctcatgcctt catctgggcc tggtgccttc cctgaaaaga aaactatatc
159841 tagcattttg ctggagtgag aaacatgctg aaactgtgca gaatgtggga gaaaaaactg
159901 ctcctaaact gcttcaatca gtcttttttt ttttttttaa tgaggatgga acataatcct
159961 atagatttta agatagttta aagaactatt tgttgatcac ttactgtatt ttgagttatc
160021 aggtgagaca gatataaggc atagctacta cagcagaggg gactgtaaga gtagggcccc
160081 tgaagccaaa aacagcatga agaatagcta gaaccagatc ctgaagggtc ttgtcaaagt
160141 atgccctttt cctgaagggt aggaaataaa tccactatta gttcattgct ttaggttttt
160201 attgctttcc tcattttacc cctacattca gaggtgtttg atgccaccaa ttcctgagaa
160261 ctggggggct tctgtggtac aaattKgtta ctccctgctt tctcagatct gtctagtcag
160321 ctattagttg ctcatctgtt ttcccagttc caaatttaaa caagagcatt taaacagttc
160381 tcttcatttt tgtgttaatg agttaagagt gagattagtt acatgtattt gaactgctgt
160441 ctatactcaa aagtctttgg ataggacatt taataaaacg ttgggtcata cacaagaaac
160501 aaggaatttt acacagtatc aagccaagat tttagtttaa agtggtccca ggttgatagt
160561 accctcagat ttctggcaga agcgatagag ggaagaggaa ttcactttcc acatgcctca
160621 aagttttcct gtcggtaaag ttccaaggaa tttgagttta gagtcacagg ttgctaagca
160681 cactaggaaa tgaagcacaa tgagcaagaa caaacaggaa atacaaagcc ctcagatact
160741 gaaattatat aaatatgttg aaagaaaaga ggaagaggcc gggcgcggtg gctcacgcct
160801 gtaatcccag cactttggga ggccgaggcg ggcggatcac gaggtcagga gatcgagacc
160861 atcccggcta aaacggtgaa accccgtctc tactaaaaat acaaaaaaat tagccgggcg
160921 tagtggcggg cgcctgtcgt cccagctact tgggaggctg aggcaggaga atggcgtgaa
160981 cccgggaggc ggagcttgca gtgagccgag atcccgccac tgcactccag cctgggcgac
161041 agagcgagac tccgtctcaa aaaaaaaaaa aaaaaaaaaa agaaaagaaa agaggaagaa
161101 aatgaatggc caagaaatta taaaaatgaa aaaaacattt tcaaaaaaga ccaaatagaa
161161 cttctagaaa agaacaattc tgtaacataa actcgaagac tggattttgt tagacattaa
161221 gaacgactaa agagggaatt ggttacttgg acagtagatc gtagaaaatt gtctagaaca
161281 cagtacagtt agaaagctct tgaaggagag gggagagaaa aatggtagaa atacaacatt
161341 taaagaatca ctgagaattg accaaaatta atgggttgct acatggttca gaaattccag
161401 tgaagctcaa gcaagtgata aaatgatggt agagaaatac atgtgcagac ataggataaa
161461 gtttgatatt tcagagtacc caaaacaaag aggagatctt aaaagcaacc agagagaaga
161521 tgggccatct aacaaaagag tgatttgact gagagctggc ttcttaatag caatagtaga
161581 aaccagaagg cagtggaatg ttaccgtcaa tgtgctggga gaaaatagct gtcaatttag
161641 aattctatac ccaattaaat cctctttcaa gaggggaaaa atgacttttc aatcaaataa
161701 actaagtttg ctactaatag acttctcaat taaggaaatt ctaaaagaca tactttagac
161761 atcataaaat aaactgtaat ggaaattagg aagcttttag cactgagtga taatatcaca
161821 aataaaaacc tatgatattc tactaaagag gtacttggaa aaaatttata accctaaatg
161881 cttacattag aaaataaaag ctacaaatta gtgaactaag caaccaattt aagatagaaa
161941 aagaacaaga tatgcccaaa gaaagtaaat ggaagaagat aagcagcatt aataaaacag
162001 aaagcaaaca tacaatacag aggctcaaaa aagttaaaag ttggtttttt gaaaagagta
162061 acaaaactga caaatgccag ctgagattag tgaaggaaaa ctggagtatg aggaatggga
162121 aaagacaatt acacatgcag agattaaaat aataataaga ggggggtatg gacaccatta
162181 tgctaataaa tttgaaattt taggcaatga ataaatgcct agaaaaatat catttatcag
162241 aatcgactta agaattagaa agtctgaaaa gtcctataac aattcaagaa gcagaatcat
162301 agtttaaaat cttgtttaaa gaaaactccg ggctcaggtg gctctcctgg gaaaattttt
162361 atttgatatt caagaaaaaa tttccaatct tatacaacct atttaagagt ataaacaggg
162421 catggtaggg gtttgggggt ggtgctctcc acctgaatga agcataatag aggaccatat
162481 gagaaaggaa atcacttgca ggtctcactc atgaagatag ttgcaaaaat cctaaacaaa
162541 atatcagcta accaaatcta gcagatataa aaaacttacc aagttgagat tatcccaggt
162601 ctgcaagggt gttttaatat tagacaatcc agaatgtaat ttaccacatt aacaaattat
162661 aaggaaaaaa taataccata atctcaatgg ctagagttac agctctgatt aaaatccaac
162721 aacaaattat cctgaaaaga agtctcaaaa taaggatagg aattttcata ataatctatt
162781 tttttcaggg attatatatc tatagtttta ttaagacaaa aactgagagt gtggtgtgaa
162841 gtttacattc aaacaaagtt ttcaaagaaa tctaacacat gcctaaaaag attttacaat
162901 gtagctctag atccaagtct agataatatc aagaactgat ggatctcatg actcaagaca
162961 gagcattttg ggtatcagtt acttcttagg atttgttaaa aaatggtttt gtgtgtgtgt
163021 gtgtgtgtgt gttttaaagt gaaccactgc ccagtatgaa agtttaatct cctgagacca
163081 aggcttttga aatcactcaa ctcttgagtc aattcagtga aacttgtgct gtcagtgact
163141 gaactctgcc accaatggtt tcagagttca aagctcaaaa gagaatggct ccaaaagttg
163201 tcccaactaa gagcatgggc cctttacttc cctcctgtct tatctcctct accaccctct
163261 ttcccttccc caacacctca gccagtggct aggatgaaca agctgatatt tataacttta
163321 ttattggaaa agaaagggtc ttctaatttc aggaattagc acctctgagg cagaatgatc
163381 tgcttgtact gtatactctc caataaaaga ccttccttcc tcagtcaatt tccatctcca
163441 aaatggcaac tctggtaact tattaactgg cttagtcctt tgtgagacta agtacattaa
163501 gtttaggcag ggaacaccat ggcttataga tttcagacat tcacagcttt taaagtctct
163561 cacagtccgt atttatggtg ccagtgacat ttttttcaaa ggtaaaatat tctggacata
163621 gaagcaaatc attagttttc tgttctttgc attgcttcac catgtcccct atcaggcccc
163681 aaattttaat caaaatgatg ctacccatct ccctttccac cctccccatt cctccctctc
163741 ccacataata caccagtaat agccaaaaac tacacatKtg ctacgctgta aaaatgtaga
163801 gttaacacta ttgggaagaa agttgtgcgt tgcggagatg ctctttgatt atctacagta
163861 tttttttgct ctcccacaca cccagttctg caagttttgt ccttcataaa gggccctttg
163921 ctttttctca gcaaagtgca gaaaaggttg ccttgaagca cttatccccc ttcccctcca
163981 ctgggacggg tgtgcaaact atacagcttg gaatggcttt aaaacacttg ggctgctgca
164041 gggcacagaa acgatactgg ctcttcaaag ggcatcttct caagctacct ctatggtgtc
164101 aagacaagta gaacttcttt ccttcccacc tgaaacccac agtcagatgt gatagaggct
164161 ggtactcagg agagttaatt cttgtcatca tcctctttgg ggtaggaatg ccacgtcagc
164221 ctttcctcat agaaggatat gacaacccgt gggcatttga cattgacttc cttggcaggg
164281 acgaggtcag cctcatcaga atttttccct ttcatcagga acatgagctc tccactggag
164341 tctgtagctc caataatctg ctccggctcc aaaccctgag caaagcctcg tggcttttct
164401 gactcttctt tcttcttctt tggtttgctc tcctctccct tatcttcaga atcagaatca
164461 gctttgtgct tgcctccctc tgatttgtct atctcatgtg ctgttttctg tgacggcaga
164521 aactcatgag gtcagggcaa tccaagttct cttctgactc ccatgtgttg tcctcatctg
164581 agaatccctt ccactttagg aggtactcca ctttgccctt taccaatcga cggtagagaa
164641 ctttttccac cacatattcc tgttcctcct cttctagcac ctcctccact ttcttcttgt
164701 tttgtttttt ctccatagcg tgtgtgtaaa gggtgatgct gctcagagca gtgcccagga
164761 gccggaaagg aatcggtgct gcgctattgg cgcattgggt cggccagggc agtggcgctc
164821 agaaaagcag caagggtagc tgcaaaggag ccccttgctg aaatggtgta ccgcaggcct
164881 cggctaatgg ccctcctctc agccgaacaa aagagccctg cactctgtgc tgcccactgc
164941 ccactgcctg caccgccttc ataatctatt aaagggtatc tacaacatac ctacagcaaa
165001 caccaacacc ataccttatg gtgagctagt aaatgctccc ctttgagatc aagagaagac
165061 aagaatgccc attatcacca tttaaattca acttttacag tagataattc taactaggta
165121 agactggaaa aataaaaaac gtggcaaagg tactgaaaag aggaaacaaa gctgctctta
165181 gtatttgttt aatatggttg ggcacagtgg ctcatacctg taatcccaac actttaggag
165241 gccgaggtgg gaggattgct tgagcccagg agtttgagac tgcagtgtta atgatcatgc
165301 cactgcactc cagcctgggc aacagagtga tatcctgtca agtataatat ttttgatata
165361 aatgtggggg cttcccccca aaaaatgctc tcagaattta atgaggaaaa taacctatgc
165421 caactcttgt ttttttttct ttttcttttt ctttcttttt tttttttttt gagatggagt
165481 ctggctctgt cacccaggct ggagtgcagt ggtgtgatct cggctcactg aaagctccac
165541 ctctcgggtt cacgccattc tcctgcctca gcctcccaaa tagctgggac tacaggcgcc
165601 cgccaccatg cctggctaat ttttttttgt ttttgtattt ttagtagaga tggggtttca
165661 ctgtgttagc caggatggtc tcgatctcct gacctcRtga tctgcccgcc ttggcctccc
165721 aaagtgctgg gattacaagc Rtgagccatc gcgccaggcc tctatgccaa ctcttacaat
165781 gagaSattca gaatgaacaa cggacacata cctgtgatac tgttttgttg cttgaagctc
165841 aattgtgaga aattaaaaca attccatatt aaatggcctc agtcttttac cctatttctt
165901 cttcatattt ggggcaattt ctgataaacc acaataaatg atgttgtagg tgacatgctt
165961 ttatctaaaa gtgtattcag aaatagaccc acacatcatc ttttacaaga gcagggcatt
166021 tgtctttaaa aaaaattaaa tcatacaaaa gaacttaatg agatccgaat caggatctaa
166081 atactgtttc taataactct caaggcagtg agtagggaca gtcagccaca gggctcacct
166141 ggttggttcc tctctctcag gggtcactgt cttttgttgc ctgattttct agtgccttga
166201 aaactgttgt ttcatatttt tttttctatg tgtttttggt tgttttaaat gggtgggtaa
166261 atctctctgt tacttcatct tggctggaag cacaagtcaa tttaattaaa tggctcatca
166321 tttcttgtat agtcctcttt tttgttaata aggagttgtt ttaacacacg ttaatacaat
166381 tgcttggcct ttcccttaaa gtttgcgtag atttatttta ttttatttta tgttatgtta
166441 tgttatgtta tgttatgtta tgttatgtta tgttatgtta ttttatttta tttatgaatg
166501 agacagggtc tcactctgtt gcctaggctg gagtgcagtg gcacaatcat ggctcacgga
166561 agcctcaact cctgggttca agtgatcctt ccgtctcagc ctcccaagta gctgggacta
166621 caggtgtgca ctaccacgcc tggctagttt ttgtattttt tgtagataag gggtttatcc
166681 atgttgccta tgccagtctc aaactcctga gctcaaggga tccgcctacc ttggcctccc
166741 aaagtgctag gactacagca tgaggcacca tgcctggctt gtttcatttg ttttgaaagt
166801 aactgttaat tttaaaggtc caatctgtga ggatctaaag agtaggagcc ctgagatgaa
166861 taattcctga aggctttcag cattctctcc tgctgtgtgc tttgttattg acagctgttc
166921 aaggtctcac cacctctgga gttttaaccc accgatgtgt ttcataaatt ttaatgaaag
166981 acagatagag agaaatcata gataggccaa catgattgta ccatatccat gcactggctc
167041 aaaatgaaaa tctctgtgat attaccctga gttacatttg tggaacacac caaactccgt
167101 cttctagctt gtctgatcca gctagctaag ggaaatcaaa agtaatttgc aaaatctttt
167161 atgttctttt atgttcttgg tacattgctc tgatttattt tttaaggcac agaaaattgt
167221 ccaaatgcat agtacaaatt tgcaaataaa ctacatatag ttatttggac gatggtgttt
167281 ttctaaggag ttttgtaaag aatgtggttt aacttgccag tgtgtaatgc taaacttatt
167341 tcttgtgtgt tattatgaac tttatttata atttcatagc agctgtttat tttcattgct
167401 aaggtacaat tcagatgttc ttggcttaac tcagtattct ctatctcaca aaatttaaaa
167461 ttagactgat actttgtaaa gattcttcag atgtggccag attattttag Raacagcttt
167521 agttatccct gataataaat attagggaga gaaaaagaaa ttgaggtctt tgaagaatcc
167581 ctaaatatca tttcagtcta tcactgtcag cctccctcac tgctttcaga tccattccca
167641 ggagcattta cagggtggcc aagcttcctc atttgggttc cagctctctt agtttctgta
167701 gcctactcat tgagctaatg agcagtgtag tggctgagag ctagggagaa atatgagaga
167761 aatcaaagaa gaccctttct gacttttgcc ctagattgtt tgaaacgaaa taacattaga
167821 ataatgagga attgaccacc tttcccttgc tgcgttttag gtgtcttttc tgtaccattt
167881 tattatgtcg tcttaatcat aacagcctac ataaatactt gagtttgggt taggatgaca
167941 atgaaaaagg gattagaaat aacgtgtact cttttttctt aagccttcag aaggactgta
168001 aaaacttaaa gatgttaaat gcaaatgcca ttgccattcc aagttaacaa gcataagagt
168061 tttttgttgt ttatttttgg ggggtgatcc ttaatagtat gtgtttttct tttcagctac
168121 caagtcagga ttgttacccc caccacctgc gctccctcca agaccttgtc catcacaggt
168181 aggagacata tttgatttat gtaaactgtt cggtggtagg gaagttgtcc tatcgctgtg
168241 cttctttgca agggttgatc gccacagatc tggtccatga gattcccaag ctgataccct
168301 gtgaagagag cagagagtgg tttaatttat tctcatccag ccagctcccc agcctcatgt
168361 ggaagagaga aagtttcYtc aataagccac caagcataca tatactagtt cactcttggc
168421 tgtccagggg tgcgtctgtt ttcatcccca gagaagggta gaagaagggg cctctctcta
168481 attggaggtg gagacatggt ttttctgtat agtatgtgca atctgggtgc ctatattttc
168541 gtcagtactt taggagctat gttaattcta cataaatgaa aaataaatgg ttatcaacat
168601 ggggttagtg ccgtggtttt ggcctatggt gctttctgta ggatggtatt tttcctcaga
168661 acaaaaagct gagatagcag gagggggaga acatgtcacc aagatctgtt tcacccctaa
168721 attaattctg ccttatttac atgtgccact atggccttat tcatcaacac tttgcagagc
168781 tgaaaatgag aagcaaacag tggagtgtgg tatatggtgc tacagatctt tccttttgtt
168841 aattgctgct gaagaaactt tctatcttta aagacccttt ctgatttttg gcagaaaatt
168901 ttgggaaatt tctctgtaca cagtccctgt ttctacttca ttgttctggg tggttcagag
168961 ctatccttcc atacggggac atctcaggac tcatgagtca ctgaaaccac ttttaacaca
169021 tgcttgtcct tctttcagtg aatgaaatgg tttttagcat ccactcaacc ttgagatgca
169081 aatactatga gatattggct tcctgcttta gtgcgaaggg taataaaaag cccatttctt
169141 cctgacctgc atataaacca gcgagaactc ctttccagga tgtaacattg gccttaagag
169201 atattggttg aaccgtcaac aagtatttat tgagtccctg ctgtatatct aatgccaaac
169261 cttagttttg ccctaagcct ttcattggct gtaatttctt ctcattcaaa ttattagctg
169321 tgtctgttga gcatctccaa taaatcaggc attgtgctaa gtgctttcag tgcattattt
169381 aatcctcaca aaacccctct gaggtagata caggtactaa tattatccct tttttttttt
169441 taacagataa ggaagttgaa gtatatgggg gctaagcaag ttacccaagg tggcatagct
169501 agtaaatagt agagccagct cccaaattgc aatctgtctc ctaaaggctc ctcctgtcac
169561 catcactgga gtctgagtgt ctatgtgtac agccagacag cagatccatt acacttgcaa
169621 tggaggcttt catcacaggc ccctaaggag gaccttgatg agatgaggct cctgctccac
169681 accaacagca aacctggact tggtcacaac aaaatgagca ggcatttgct agctgctagt
169741 tcaagcctgg ggcttgagag ccacctggtt gaatgcatgg aagacctgtc tgaattgact
169801 tttgtaacca accttctagc tttctcttcc tgcacaaatg ccagtagtta ctacccggtc
169861 ccaaaatatg ctgctgctat cagcagtctt catctgagct gcttgaggtg ggcttcttgc
169921 ctgcttttgg agcttagtca ccaaagatct gactggggga tctgggaatt ctctagtcac
169981 tgttaatgaa tgagtctgct tctttgtcta ccagatttcc catcacaata taaacagtga
170041 gcccagtact cagcctatca gctgcctaac tatggagatt tcagatttca ggaacaggtg
170101 tgtaagaaat ggaggcagaa gatccacatt ccatttctct cccctattcc ctcctttcac
170161 ccactgtaag tgggacacac atattcagat atatgaagtc ctgggcaata aacacatggt
170221 tatatttagt ttttgtgcca tgtcaagttg gtattgaccc tatgagcgtc ttactaacca
170281 ctttgtatgg gacacctata tattctagtc tttcccaaac tgcttgtgat aaaacagtct
170341 ctgggagata ttaatagggc tctgtggtac agatttgcag actgctgccc ctctacccct
170401 ctgggagagt cgctgtgcaa gtgagctcac taaaggcttt ggaggcctac agtaagtaaa
170461 gctagtaaat tttgttaaag ccagcaattt cctagcttct gtgaccattg atatctttat
170521 ttataaaata cctgttagga tacaaaatca gtgtgcaaaa agcacaagca ttcctttaca
170581 ccaagaatag gcaagcagag agccaaatca tgaatgaact cccattcaca atcactacaa
170641 agagaataaa atacttagaa tacagctaac aagggatgtg aaggacctct tcagggagaa
170701 ctacaaacca ctgctaaagg aaattagaga ggacacaaac aaatggaaaa acattccatc
170761 cttatggata ggaagaatca atatcgtgaa aatggccata ctgcctgaag taactttttt
170821 tttttttttt gagacggagt gtcgcactat cgcccaggct ggagtgcagt ggggtgatct
170881 cagctcactg caagctctgc ctcccgggtg cacgccattc tcctgtctca gcctcccgag
170941 tagctgggac tacaggtgcc tgccaccacg cccggttaat tttctgtatt ttttagtaga
171001 gacgggattt aactgtgtta gccgggatga tctcgatctc ctgacctcgt gatccacctg
171061 cctcggcctt ccaaagtgct gggattacag gcatgagcca ccatgcccgg ctgcccaaag
171121 taatttatag attcaatgat attcccatca aactaccatt gacattcttc acagaattag
171181 aaaaaactgt tttcaatttc atatggaatc aaagaagacc ccatataacc aagacaatcc
171241 taagccaaaa gaacaaagct ggaggcatca tgctacctga cttcaaacta tactacaagg
171301 ctacagtaac caaaagagca tggtactggt atcaaaatag acatatagac tagtggagca
171361 taacagagac ctcagaaata acaccacaca tctacaacca tctgatcttt gacaaacctg
171421 acaaaaacaa gcaatgggga aaggatcaaa ggtcaaaata aagggctcta ttttaaagtg
171481 aaatcaggtt ctgataaatt tatcatttgc cctagataac attgttttaa gtttatcaag
171541 gttgaatatt caagtggaat gcttgttttg tgtaatgtat ttttcctttg ttaactttgg
171601 cagtaccttt tactgtatgt tccctagtta tagaatcggt tcatagattg ctcagagcta
171661 ctcatatctc tggattcatg tattatgaag aaacaattct gtttcagacc agcttgtgtt
171721 gattgaatct caagttttgg aagttctctt gtgaggattt cttaaatttg aaaactacta
171781 ttctcaagta gttagggacc ataggcacac actaccaaac ctggctttcc aggttttaag
171841 tatgtaagaa aaatgagttt gtacatttgc aatatgcata cagagatata taaagattgt
171901 ttctacatac accaaaagca tatattcttt tatcaaatga gagagatgaa gtataggttt
171961 tcagcataac atgcagttta gctggctcat acttattcaa gcaccactgt gatatgaaca
172021 tctggattaa gttatacaaa tggggccctg gagttaggaa aaggaataag ttaaaagaaa
172081 catcttttta tttttcatac tataggtaag atcaagaaga acctagtgac tatatacaaa
172141 attaagtagt ttgtgtttca cattttcctg tggcaagact agagactagg gcatggtctt
172201 ttggctcagc tcagaagagg tgactttttt ttgaaaaaag acttatttat agcataaata
172261 accaaaaagc aattaaagta aactatttca tatagagcag tgcattcttt tgtttgtttt
172321 tgttttgttt tcttaagacg gtctcgctgt gtcacccaga ctggagtgca gtggcatgtt
172381 cagggcttac tgcagccttg acctcccagg ctcaagtgat cttcccacct cagcctaaag
172441 tgttggggat tacaggcgtg tgctactgtg cccggcctag agcagtgtta aagtgagagt
172501 taaatgtatt agcccactgt ttgtatcatt ttaataaatc cagtaaattg ccatctgtag
172561 agtttgtgtt tattcttttt tttttttttg agatggagtt tcgctcttgt tgcccaggct
172621 ggagtgcaat ggcgcgatct tggctcaccg caacctccac ctccccggtt caagcgattc
172681 tcctgcctca gccttccgag tagctgggat aacaggcatg caccaccacg cccggctaat
172741 tctgtatttt tagtagagat gggggtttca ccatgttggc caggctggtc tcgaactcct
172801 gacctcgtga tctgcccact tcagcctccc aaagtgctgg gattacaggc atgagccacc
172861 gtgcccggcg agtttgtgtt tattctgtag gtcagttctc tgccaaggga ctgtttggta
172921 cttcagtagc taagtccttt taatagtgtt gatctcatga cagttttctt atggcaattg
172981 tgatagagcc acagcttcag tgtaactata ataaagaaaa gattttgggg gtgcaagaca
173041 ttatctttta agttttctat tagcaccaca tttgataaat tggggttccc tgcagactaa
173101 tgtgctcaga attttcctat ttctgccact aatttctcac cttatatgta acaaagtttt
173161 cctcactagc aatgtaatga gtactaaaaa tagcactgga aggtgaaagc actgtgggag
173221 aagcatttga tgaatacctt taagcttaga gagaccaaga agactcatgg aaggggtgag
173281 atgaccaatg aaattagttt taaagaaaca acagaacttt tttttttttt ttagctggct
173341 aaaagataca gagctttact gcagatttaa aaaaaaaaaa aaaacccaaa tgcagagaaa
173401 caggcttgca agaggtcctg gtatgtttga ggagctgcct gagatttgga aagccagatt
173461 gtagggaaaa tggctgtagt gttctggaag tggccatggg gagcaagcct cctgctcact
173521 tccagttcca gttctggtag ggatgtggga gagaaacagc ccctaccaaa ggagttctgt
173581 ctggggagca gaaactgacg ggaggacagg gttttagcct agtggttctc acccttggct
173641 gcacagtgga atcatctggg ggagctttga acgtgctgag gcctggagcc cctcccagag
173701 attttggcat ggggtgctga ggtccggcca ctgggaggtt taaaaacctc tccaggtgat
173761 tctgaagtgc agccagagtt gagaagcact gaattagggc aagaggaagg aatgctcaga
173821 gaagaggttg agaatatagg gaattttatt gatgagttct tatagggcac aatgaaaggg
173881 gttctggagt tggggaggca tgaggtcagc ttaggggatg tactcagacc ctatggggac
173941 aagaactcag atcacaaggg gcctgggagt caagggattc ttgtggtgac tgatgtgaac
174001 agggctagag gatgtgacag gaaggtcctg ctggaagaac tagtcactgt gtgcctcagg
174061 tcctgtgtgt actactgtga gaggctagcc atgaacacag atggcctcaa gaggaaacca
174121 gaacaactgt ggtccattga gttaattctt catctaactt cataatctgg ctagaatcag
174181 gtcctgaaag tgatattgaa cccaatagga atatggcagt catgctactc tttttcaaag
174241 actaattttt tagacacaac tttttataaa atactacatt tgttttattt ggaagtaaaa
174301 actgcagctc acttaaactt aaatggcagt tcgtaggccc tgaatttgtg aaatattcaa
174361 caccatttta aatactctat ccttttaatt aatatcctgt catttaaatt attctttcca
174421 caagttaata cacagttggt gattcaaaat agtaaattct tctgggagaa attaagagtt
174481 ttagaccaca catacttttt tggggcaggg gaaggaattc ctggtgatta tgtaagtctc
174541 ttacagggct atctaatcca tttttaagtg ttaattttat taaagcataa catacatact
174601 gaatctattt ttaatacata ctaaatcaat ttttaagata gtaaaatgaa gtataggttg
174661 agtacccttt gtctgaagtg cttgggacca gaagtggttt agatttcact tttttttttt
174721 tttttttggg aatatctacg ttacacttac ctagttgacc atctcaaatc tgaaaatcca
174781 aaatcctaaa tgctccagtg agcatttcct ttgagtgtca tgttggtact caaaaagttt
174841 tgggaggccg aggtgggtgg atcacctgag gtcagaagtt cgagaccagc ctggccaaca
174901 tggtgaaacc tcatctctac tcaaaaaaaa aaaaacaaaa attagccggg cggggtggca
174961 ggcgcctgta gtcccagcta ctcaggaggc tgaggcagga gaatctcttg aacctgcaag
175021 gcggaggttg cagtgagcca agaccacgac attgcactcc agcctgggca acaagagtga
175081 aactctgtct caaacaaaca aacaaacaaa caaacaataa aaaaagaaga ggccaggctt
175141 agtggctcac gcctgtaatc ccaacacttt gggaggctga agtgggcaga tcacctaagg
175201 tcaggagttc gagaccagcc tgaccaacat ggtgaaaccc catctctact aaaaatacaa
175261 aaattagcct ggcgtgatgg tacgtgcctg taatcccagc tactcgggag gctgaggcag
175321 gagaattgct tgaacccagg aggttgaggt tgcagggagc cgagattgag ccactgcact
175381 ccagcgtggg tgacagagca agactctgtc tcaacaacaa caacagaagt tttgggtttt
175441 ggagcatttt ggattttgta ttttYggatt ttggatactt aacctgtatt atattgttgt
175501 cagctttcaa atatctataa gaaaatagca agaaacatta tttaatgtga acaatagaga
175561 aatgtcactg cttttaaaat tgcatgtttt ttttatcaaa ttaaaactcc gtgaataaac
175621 accaaacatc atgaaatctc ttgctgtaat atattcaaat gacctcatgt aatatataag
175681 tcattgaatc accttaagat actgcctgtt aaagcatatt tatgaacttt caaaggtata
175741 tacaacatcc taatttttac tcatcaaaat acgaatttaa tatgtatcaa gatagtttct
175801 attcatgcat gtattagaaa atcagaaatt attccaaagt gaatttataa acgtatatca
175861 cttaagatgc caccttcatt ttcttccaaa gtgttacttt gttctgtcct acagtgtatg
175921 ctgtagatta gctgaaaatc acaacatgtt aatgagtatt tcagtgatta aggaaagaag
175981 atataaacca aggctgtacc ttcatttgtg atgatgaaag aacatactga aagctgtacc
176041 acactgtgct gaatgtagta atatgaatgt gtctgtctgt ggtcttatcc ttagtcctgc
176101 tactgtgtag ctctctggct ttgtgggaat taagtaagtt agtctcatgg aectatcgec
176161 ccttctataa agtaagaaga ttggactaga gggatcctac tagtgctaag atgtctgatt
176221 ctattttgta ttctctgttc aagaattttt tttgtaatat agataaaact tcatgaaaca
176281 cagttgaggg acaagatagg ttggactaat tttctctgct cctccctgct aagtacaact
176341 aaaaccccca gaaatactat aatggaaaga ggattttttt tttttgagac agggtctcgc
176401 tctgttgtcc aggctggagt gcagtggtgt gatcatggct tactgcaccc tcaacctcct
176461 gggctgaagg gactcagcct cctgRgtagc tgggactata ggtccttgct gccacaccga
176521 gctaatgttt ttattttttg tagagacagg gtcttcctat attgcccagg ctggtctcaa
176581 attcctgagc tcaagtaatc ctcccacctc agcctcccaa agccttggga ttacaggtgt
176641 gagccatcat gcctggccag aacagacttt gaaaggttta aagaggaaag aggactggca
176701 tgacagtgaa ctagagactt caagtagaca gaagaccaat aaggaaatag aaagcttgaa
176761 caataccatg gttcaacttg atataacata actatagaac acccagcatc agcacaatag
176821 acatttttct caagtgcact tggaatattc ttcaggatag accatatgtt aggccacaaa
176881 acaagtctca ataaatttca aaagattgaa attatattaa acatcttctc tgatgtcaat
176941 ggaatgaaac tagaaatcaa taacagaagt aaaatggaag attcactaat atgtagaaat
177001 taacatactc ttaaaaacac aaagaagaaa ttataagtga aattagaaaa taccttgaga
177061 tgagcgaaaa caaaatcata tcaaaaccta tgggatgcag tgatagcagt actcggcggg
177121 aaagttttag ctataaacac ttaacattaa aaaagaagag atccaaaatc aacagttagc
177181 tttacacctt aagaaactgg aagaaggctg ggcacagtgg ctcacgcctg taatcccagc
177241 actttgggaa accaagacgg gtggatcacg aggtcaggag atcaagacca tcctggctaa
177301 cacgggaaac tccgtctcta ctaaaaatac aaaaaaaatg ttattctggg catggtggcg
177361 ggcgcctgta gtcccagtta ctcgggaggc tgaggcagga gaatggtgtg aacccaggag
177421 gcggagcttg cagtgagcca agattgcacc actgcactcc agcccgggcg acagagcaag
177481 actctgtctc aaaaaaaaaa aaaaaaaaaa aaaaagaaac tggaagaaaa agagcacact
177541 agatccaaag ctagcaggac agaaataata aagagtagag tggagataaa caaaatagag
177601 aacagaaaaa caRcagagaa aatagttgaa aagttgattt tttgcaaaga tcaacgaaat
177661 tgacaaaact ttagctagac tgaccaagag tataattaag catgtgttaa cctctggtca
177721 aaataaaggg ctctatttta aagtgaaatc aggttctgat aaatttatca tttgccctag
177781 ataacattgt tttaaattta tcgaggttga atattcaagt ggaatgcttg ttttgtgtaa
177841 tgtatttttc ctttgttaac tttggcagta ccttttactg tatgttccct agttgtagaa
177901 tcggttcata gattgctcag agctactcat atctctagat tcatgtatca tgaagaaaca
177961 attctgtttc ggaccaacct gtgttgattg aatctcaaga gttttggaag ttctcttatg
178021 aggatttctt aaatttgaaa actattctca aatagttcgc actgaatgac aaattcaaaa
178081 ggcaaaggaa atggccatag tgataagtgc aaggagaaga gagggtgaga attagtaatg
178141 aaataccagc attggaatgg aggagaaaag tgtaagcctg tcccccttcc ttctttttga
178201 aagaagtRct cagcattttg ctctttatca ataagtgtct ttagaattaa tcctagtaac
178261 taattcaaaa gaaaRgaaaa gttctatgat gacatttatt ttagtattat aaaaataaga
178321 acaatacaga ccaccttaat atctaggaag aaggcactgg tcaagggtaa tgtatatctg
178381 cctgattaga atattaggca tctattaaaa tgattacatg acaaaacagt agaaaagagg
178441 ggtaacagct gaatacagag gtgtttcctg attgtaccac ataagtatat ggtagacctt
178501 tgatggtaag gttttctcat ctctgaggat gaccttgaag gtccatggtg catggtaatt
178561 ggcccctttc cagtggtcgg atttcgaatt acttttacat tagccactgt tccctcccca
178621 gtagggtttt gagattctta gctgcttagt gaatttctac taactctttt taggggtcta
178681 aagggatcgc ttaggtgact catttataat ttacctatct tgtcttataa cttgttttta
178741 taagttttta tattttggga gatgatgtat gtgtagtatt tatgtgaatt gggatatctg
178801 tgaaggtctc cagatggttc agtcctaaat gtcaagtgcc tactgttaaa tacttggaga
178861 agactgctaa gtaattggta gaagtttaaa tggctgtttt ggtggggaag ttatgcagtt
178921 tttcttttaa aaattttgtc ttaaaattaa ggattgggga aaagaaaaaa aagtcctctg
178981 atatgacaac tagaataaaa agtcatttga agatttacca gaataaaatg acctttggaa
179041 actactttta gagaccaget ctcagaaata gtgataagac atatattgca taattacatt
179101 gttacgatga ctctagcaat tgtgaggttc aaagaaatag tgtactgaag tattatcatc
179161 tagtcatttt ttaaatctat gttctttgga tagtaaactc ttattgccct cactcttaaa
179221 tagtaattct gctgtgtaca gaattttaga ctgaaagtaa tttttcctca gtattttgaa
179281 tgcattacct cctcttctag catttattgc tgccactgct ccggattgta ctgtcaatct
179341 attttttatt cctttggtgc agctttgtct ttcctctggg attgctttta aaagtttatt
179401 tttactttct gaaggggtgg gttgcccctc cacacctgtg ggtgtttctc gttaggtgga
179461 acgtgagact tggaaaagaa aaagacacag agacaaagta tagagaaaga aataaggggg
179521 cccaggggac cagcgttcag catatggagg atcYtgccag cctctgagtt cccttagtat
179581 ttattgatca tttttgggtg tttctcagag agggggatgt ggcagggtca taggataata
179641 gtggagagaa ggtcagcaga taaacacgtg aacaaaggtc tctgcatcat agacaaggta
179701 aagaattaag tgctgtgctt tagatatgca tacacataaa catctcaatg cgttagagag
179761 cagtattgtt gcccgcatgt cccacctcca gccctaaggc ggttttcccc tatctcagta
179821 gatggaacat acaatcgggt tttataccga gacattccat tgcccaggga cgggcaggag
179881 acagatgcct tcctcttgtc tcaattgcaa gaggcatgcc ttcctcttat actaatcctc
179941 ctcagcacag accctttacg ggtgtcgagc tgggggacgg tcaggtcttt ctcttcccac
180001 gaggccatat ttcagactat cacatgggga gaaaccttgg acaatacctg gctttcctag
180061 gcagaggtcc ctgcggcctt ccgcagtgtt tgtgtccctg ggtacttgag attagggagt
180121 ggtgatgact cttaactagc atgctgcctt caagcatctg tttaacaaag cacatcttgc
180181 accgccctta atccgtttaa ccctgagttg acacagcacg tgtttcagag agcacggggt
180241 tgggggtaag gttatagatt aacagcatct caaggcagaa gaatttttct cagtacagaa
180301 caaaatggag tctcctatgt ctacttcttt cgacacagac acagtaacaa tctgatctct
180361 cttgcttttc cccacacttt cRgtgttctg ttttgatggc gctgcgatgg gtttaagcgt
180421 agatttaaat ttgtttatgc caggtgacac ttggcatgca ttttccttct ggaaaatcat
180481 ctttaatttt aggacattta gtgatatctc tgtgggtttt gcttctctac ttatttcttc
180541 tgttttcttc tggaactaac tatatttctg tcaacacatt taaaaaaaac tctagtaatg
180601 tgtctttcat cttttttttt tcttttttga gacagggtct tgctctgtca cccaggctgt
180661 gcaatgggat gatccatggc tcactgcagc ctcaacctcc tgggctgaag ctgtcctccc
180721 acttcagcct cctgagtagc tgggactaca ggcgcatgcc accacacctg gctaattttt
180781 tgtatttttt gtagagatgg ggttttttca tgttacccaa gctggtcttg aactcctggg
180841 cccaagcagt cctcccatct caacctccca aagtgctggg atgtacagat gtgagcaccg
180901 caccttgtca ctttcatcta tttatgttgt gatctttctg ggcttgctct ggatgaaatc
180961 ttcatcttcc aaattaaaaa tcctctgcat aactatatag cctagaattt ttcctattct
181021 gttattaagc ctctatcact attctttgat tctaggtttt ataatccatt cttttttata
181081 acaacctgtt cttgttttac ttttccctat ttttgtttta tacccatcta ttctttttta
181141 ggatctattc tccactttta actttgagga ttctaaaata cttactttaa agttattttt
181201 aacttgttct atttttgttt ttgtcaggag cgaatttgcc ttttttattt ggctgttcta
181261 ccatgctttt tggaattttg ttttgtaggc ttattttgag ttggagttca atctcattct
181321 cagttctctg agctcctcac tttctgccag ttcagtggct gtctctacca actattcctg
181381 gcatccatgg cctccagtca agagctgatt cttatacttg aaatacagta cttccatctg
181441 gtgcaggtgt caggggtctt gtagatggca cccaatggtg cttagcccag aaccaggctt
181501 cagtgttata tctgcttcag ttcctttcct aagtaggcaa cccagagctt ctccacaggc
181561 ttcatcttgg ttttgcagct tcacaggtag caaagtgata ccttagcctc tggcatcagg
181621 gaatgagctt ggtaccagtc ccctgcctca tgcgggacat ttatttattt ttatttttta
181681 ttattattat actttaagtt ttagggtaca tgtgcacaac gtgcaggttt gttacatatg
181741 tatacatgtg ccatgttggt gtgctgcacc cattaactcg tcatttagca ttaggtatat
181801 ctcctaatgc tatccctccc ctcttccccc accccacaac agtccccagt gtgtgatgtt
181861 ccccttcctg tgtccatgtg ttctcattgt tcaattccca cctatgagtg agaacatgca
181921 gtgtttggtt ttttgtcctt gcgatagttt gctgagaatg atagttaaca gcttcatcca
181981 tgtccctaca aaggacatga actcatcatt ttttatggct gcatagtatt ccatggtgta
182041 tatgtgccac attttcttaa tccagtctat cattgttgga catttgggtt ggttccaagt
182101 ctttgctatt gtgaatagtg ccgcaataaa catacgtgtg catgtgtctt tatagcagca
182161 tgatttataa tcctctgggt atatacccag taatgggatg actgggtcaa ctggtatttc
182221 tagttctaga tccctgagga atcgccacaa tgacttccac aatggttgaa ctagtttaca
182281 gtcccaccaa cagtgtaaaa gtgttcctat ttctccacat cctctccagc acctgttgtt
182341 tcctgacttt tttttttttt tttttttttt ttttttgaga cggagtctcg ctctgtcgcc
182401 caggctggag tgcagtggcg ggatctcggc tcactgcaag ctccgcctcc cgggttcacg
182461 ccattctcct gcctcagcct cccaagtagc tgggactaca ggcgccYgcc actacgcccg
182521 gctaattttt tgtattttta gtagagacgg ggtttcacca ttttagccgg gatggtctcg
182581 atctcctgac ctcgtgatcc gcccgcctcg gcctcccaaa gtgctgggat tacaggcgtg
182641 agccaccgcg cccggccgtt tcctgacttt ttaatgattc atgtgggaca tttaaatccc
182701 tgttattagg aactctcagc tgcctctgtc tgcttctgca ccctctgcct gcttctgcac
182761 cctctgcctg acctaccact ttgtgatttg gccccacaga gacctttatc ttgcttctga
182821 gtgggactga gtcttttaaa ttttaacagt tcatgctaac actctcacat ctgtcattgc
182881 atatcatttt atgtaagggg aagttgagat tcagagagca gaagttaact acttgggcct
182941 cgcagttggt aagtaagcca gcctgctgta gaagaaaagg gctggaaaag gtttctgggg
183001 aagtgctaga aatttaataa gcatgtagag agagaaaaat cattcattat acatcacaaa
183061 aattaactgt agatctgcta agtaaaagtt gattaaattt ctacactctg tgcccaccaa
183121 taattttcta aatgtgaact ctttcctaca ttaatctcaa atgcttattt ttaaagtgcc
183181 ttccccagtg cagacttaca ttcatcttag ccaaaatggc cttcacattt ggtctgtggg
183241 acatatttga tgtagcaaaa ggccaagggt aacccttatt ctacccccta aaagggaaca
183301 gaaagagaac ttttgcataa taaataatta tttatgcatt tcaaaattga ttttaagagt
183361 acacaaacca tagaggcttt gcgattcttc atgtatttta ttaatttatc aagcacttca
183421 acagagtgcc cgatgctctt ctagatgctt tacaaatatt aactcattta agcctcacaa
183481 caaccacgtg cagtgggttc tattgctatc ctaacattgc agataagtaa acaaggcaca
183541 gagaacctca gcaacttgct tgaggtcagt gacagaaaga aagagttaag gctatgattc
183601 ctaccttggc tatttagccc cagtgtacca gctcctacta tactactatg ctgtgctgtg
183661 aaaccacgtc tcacaattat tttattaaca atcaaactga cacactatct ttgtcaggga
183721 cacattttat ttcatggaac tagttaaaaa ttagctttaa ctcacttctg gtgacttgtt
183781 ttctttctta ggttcttcct cattatatta tgcccatgct attgttatat aaagctcact
183841 ctgctggtat cattcttctg gaagatgcca taaattcatc taatcatttc atcagatgtt
183901 aacggaatgt gctcactgta ggcccacagt ttgctgagaa ctataggagc acaaagattg
183961 tgatgtgatc cttatcctgt agttccttta tcctgcgtca ccctctcaca gcagtcatgc
184021 ccaacactat ctattctata gtctctcatg gttcttacaa ctgagtcatt ttctgtgtgt
184081 ctcatttaaa cccatttctt aatgctttat tgacacaggt tgtaagcaat aaactggtca
184141 ccatgtttct aataactacc aatatagccc agttttcccc tggggggctc agttatggtg
184201 gttttctagg tttYtgagca atggaatcct catttctctt ctctgctgtc ccctatcgca
184261 ctgtgacttt tttttttttt tttttttttt tttgagaaag agtcttgctc cgttgcccag
184321 gctagagtgc agtggcgcga ttctggctcg ctgcaacctc cgcctcccag gttcaagcaa
184381 ttctcctgcc ttagcctccc gagtagctgg gattacaggc acatgccacc acgtccggct
184441 aatttttgta tttttagtag agatagggtt tcaccatgtt ggccaggctg gtctggaact
184501 cctgaccttg tgatccacct gccttggcct cccaaagtgt tgggattaca ggcgtgagcc
184561 actgtgcacg gcccacactg tgactttaag gaagcactcc tgagggggtc aggggaggag
184621 cagatgtgga ttgggaggat gcccaaatgt gctactgtgc taatgggaaa ggacaatgga
184681 ggacaaccag gggttgggct cagggaggca gcttgacaga ggatttaaga gcatgggctt
184741 ggggtttcaa atcctatctg cctcttactg gctttgtgac tttgggcaag ttagtctctc
184801 tgtgcctcaa tttcatcatc tgtaaaatgg ggatcatggt agtatccatt ttcatagggt
184861 tatgatgatt aaatgagtga agatctctaa agcacttaga atgatgcctg gtgccatagt
184921 caaccctcaa taacatttag ctgttataat tatcatcacc acaggcctag tgaaacagag
184981 gtggggtcta gttggcaaac acagaacaga ctccagatag ctagaaatta gttgcaacca
185041 gcccagaatg agtgctgaag tggctcgcta aagcacttgc agtcaaagca cattgttacc
185101 ctcatctgtg acctttcatg ggctgtctct ctgcctatgt caggggttgg caaactatag
185161 cctacaggcc aaatccagat ggtcacctgt ttctataaat aatggaaatg tgaaggagaa
185221 tcaattggca agaggcacgc atagcgcatc ttcaaccttt tccatcgggg aacatgagtc
185281 ttgagaatcc tgccatagat caaaagaatg gcaatgagaa gaaccagtgg acaggtggat
185341 aggcctcccc atcagccttt aaccctcctg ctcttatctc aaggatcata tgcccgtgtc
185401 tgtggtttct gatttttcct tgaggacctt tgaccgagat gatctgtctt tcagacttta
185461 ctagcaaaat tctgagcagt atcttttata caactggcag cttcaaaggc ttgcagtggg
185521 taggcctccc caactctgtt tcgcaagata attaaaagaa gccagactcc ttcatccttg
185581 aaggagagga agaagaaaac aagcctgtcc agagaaaatg gggtgaagga atttttctcc
185641 ccaacttcct cctaaatacc ctgctctgcc catcaaattt tgtaagtatc acccagtggt
185701 gtgttggtaa accttctccc ctgcggggtg ggggaaagcc ccaatttgca gccgttgttg
185761 ctgtctgtgt tgtgaatgct cccaccatgc tgactgcaag tggagctggg aagagatgtg
185821 taccatcggc tcactaacac tagcatgctc tgtggtagac agcttccctt gcctctgaat
185881 ccttgtgtca ggattctacS tgccaggcaa caagagcttt ttttctttat gtatcatgcc
185941 agtgatttta gtctagggca ctgttttagc ccaatcccag aatgtgctat tagaaatggg
186001 gccatatttt tgaagttgct aggggcaaaa cttccctctt gtttatgttt aacttgtgcc
186061 actaggtggc actttaagga cattacagga aatcggctct actggatttt taaaactttt
186121 ttttttttga gacggagtct cactctgtcg cccaggctgg agtgcagtgg catgatctca
186181 gctcactgca acctccgctt cccgggttca agcaatttag ctcactgcaa cctccacttc
186241 ccgggttcaa gtaattttcc tgcctcagcc ttccgagtag ctgggactac aggcatgtgc
186301 caccacaccc agataatttt tgtattttag tagagatggg gttttgccat gttggccagg
186361 ctggtctcaa actcctgacc tgagttgatc tgcccacctc ggcctcccaa agtgctagga
186421 ttacaggcgt gagccactgt gcctggccca aaacactttt tattgaagta taattgcata
186481 tagaaaagca agctgcacat ttaatgtgca actcaatttt cacaagcaga acacatgcat
186541 ataatcagca cccaaatcaa gaaacagaat attactagca ccccagaagc cctccttgtg
186601 ctgttttcca gtcgctatct cttattctta gggttaccac tattctgact tctaacagca
186661 taaattagtt tgacttgtgt tctactttat ataagtggaa ttatgcggta tatactctgt
186721 gtctggcttt ttattaaatg atgtttgtgt gatttattca tactgttgtg tgtaattgag
186781 atcattgctg tatagtattc cattgtatgt gcaaatataa cactgttttc tactattgat
186841 ggacattttt gtacttttca gatttgggca attatgaata gtgctgctgt gaacactcgt
186901 atccaagttg ttgagtggat gagtgttttc atttctcttg gatatatacc taagagtaga
186961 atttctaggt catggtgtag gcatatgttc agctttagta ggtactgcca aacagtttta
187021 cgaagtgttt gtactgattt acactccatt aatggtgttc ccactccagt tccatgtcct
187081 catcaatgct gaatttattt tatggatggt tcctaactct taacataatt tttatagctc
187141 cctttctggc cagctatttc taattgaaaa attttaaagc cacattattc tgatggacat
187201 ggctcatgca ggaagggcta tgtcaaccca aaaggggaca tttatcacag tctaagtgtg
187261 aactatcagt aagtcggaaa ggatgttact ctaatactcc atcacactga tacacagagc
187321 aaagaaacca ggaaaggaat tcagattgta agtgtgataa aatatcggtt cataggccag
187381 ggctctgagg cattttgaaa tttgtatata catttgttat tattgccagg cctatatatg
187441 tcagagattg gggcccaaca gaaagaattt ctaaaggcct cataatgaag tgcctttcaa
187501 ttgtgctgct ggtgggtgcc tgttttacta agggtctctt tggtttggca agaggcatgc
187561 atggggcatc tttcttcaac ctcatccctg gggagcgtga gtctctagag aatcctgctt
187621 tagatcacct tacctgtgag gctcatgttg ttgactctgc agatggtgtt ataatatggc
187681 tttaggtatg tgatatagag agtacagttc agacttgact cagatttctg ttccattact
187741 agaaattgga catagaagaa caaaacccag gtcatggtca aaatatttgt cttttagacc
187801 aaaataaagt gctcatagtc ctttagttgt aacagtaagt ctgtctcatg gatgttgtcc
187861 ataatctaat gggttccaag aatccccaag gcattctgcc atgtgactct tgaatccagc
187921 aactagttgc ccattatagt cactggtacc cactttcacc aaagttgttc ctgagcccct
187981 ctgtcagtgt tttcctgagt gtctccagtg ttggattggt ctaccgaggg gggtgcccac
188041 cagagatgtt cactgcacac tgcctgagat atccatgtta aagcagccgt gaaacatgaa
188101 agtctgaccg ggcttttatt tttaaaattt tctcccccca atattagtag cggtaatatc
188161 cagtggcaca gatttagact gtggatagcc tgctttgtgg gatctgctta tattctaaat
188221 tggagccagc attttctcag cctaggtttt catctgtttg gcaaggagga aaatgccctt
188281 atgttggatt ggctgctgct tgcagtagga ggaactatgc ctgggaaacc aatcataatt
188341 ttaatcctaa tgataatagt agctgctgtt gtcaaacagt tactgtgtaa ttgtgcttag
188401 cacactagac agatattttg cttaatcttc acaatattgt gagttaggtg aattatccca
188461 ctttgcagat gaagaaattg cagctcagag agactaagca tgtgaccagc tcacacaatg
188521 agcaactgca aagcctgggt ttgactccag agcctatatc ctgtaactgt tctgtgctct
188581 gtgggtgcag ttaccaagga atgaattact gacctcttct ccagtggaac atgaaacagt
188641 attgggttca ttgctggctt attccacaca ttgattagag gacctgttgt ttgctggcat
188701 gcagcttagg tatcaagaaa atgataggga agcaagacag atcctgccct ccaggtgctt
188761 accattcgtt tatcatgttc tgtctctcac aggtgacttg agtcatggat tttggtaatc
188821 attcttgctg agaattcagt ctcttggacc ttcttgaggc tctatttacc cctctctctg
188881 agcctggttg gggaatgatg gggtggaaca gtggtgtgct gggccattgg ttctacatct
188941 tctgtgactg ggtttagcaa atggctttct gttgtgttct tgcctagcgg agatggggga
189001 caggtgaaaa ctaggcacca aatgacattt agaatactga cagaatgctg gaaaggccct
189061 ggaggcagca gcaggattgt cttcttgtct gcctagaatt tagctgctgc ctttgtgatc
189121 cccattcttg gaatccacct ggatccttgg atgataaagc ctgagttcgt ttttctgacc
189181 tgccaatatt gcaaacctaa aaaaaaaaaa gttacctatt atccacacct tggcaaagtt
189241 ctacagatgg acttcttttt tttttttttt tttgagacag agtcttgctc tgtcacccag
189301 gctggaatgt ggagtgcagt agcgagattt cagctcactg caacctccgc ctcccgggtt
189361 caagtgattt tcgtgcctca gcctcctgaa tagctgggat tacaggagcg tgtcactacg
189421 cccagctaat ttttgtattt ttagtagaga cggggtttca tcatgttggt aggctggtct
189481 caaactcctg gtgtcaagtg atccacctcc caaagtgctg ggattactag cgtgagccac
189541 catgcccggc cagactattt tttaagtggg atttgacttt ttttttggtt gcaaatttga
189601 cttttaaaca aaatcttact gctgaagatt ttgcccagct gcaaatattt atctatagaa
189661 ccatgtggca tataccccca ttccctctat gatgaatgga tgagaaaaca attaagaagc
189721 ctagttagtt ttgcaagagc acctgtggcc ttgcccagac tagggccttg gagacttggt
189781 tttctcatct cttaaatgaa gagtttggac catcagtggt tcccagttga tctgggctgg
189841 ctacataaaa atcacttagg gtgcttgtta aaatataagt ttctaatgcc ccatccctaa
189901 gggattctga tgagggaagt ctggaatagc atctacaaat ctgaatttat aaaaagttcc
189961 ccagataatt atcctgctct ggttatattt gggagccact gggctagagg gtctagaaca
190021 aacataatta agttagggag aaacttctga tgtgcttgaa gatttgggga atacctatat
190081 gcctggagca ggttccatat gggcgaacta acccagttat gttgcagagg taaattggag
190141 ccagaggatg gaagaccttt aactggctga gggattgtgt tgtgtgccat aggctttggg
190201 gagccagtga agggctttga gaaaaagcat tttgattaga tggtgcttta ccagattaat
190261 ttctcagtgg tgtgcagggt ggatcagagt gcactagaac tgaaggctgg aaaaagaccc
190321 agtgaagtct ttgcagtggc ccaggtgata agtgtgacga gtacctggac tcagatggga
190381 ccagtgggac ctttgtaaag ctaacctgcc tcagtggaac tggaatctga gacatactgt
190441 tttaaactcc ttaaaaaatg cataatttat taatgtcatg ttcatctgcc taaactatta
190501 taattaacta tttttattgt gtttttgtcc aagaggtttt aaaggagccc tgtaaataaa
190561 ttcatgcaaa gaagtagttg gcagcagcaa cagctgctac cgcagggaga agggaccccc
190621 ttctggccag gcagcaacct cattctcacc ctgtctccat actctaagcc aaagcgagag
190681 gggaggggag tgcaacaggg gcccctggag ttggatctgc caaccacagt ggagaatgca
190741 cctccccaag ggttaggtgt ggaatatggc gtttggcatt aagtcaaata gaatattctt
190801 cctttgttcc tctaaaatcc agtctatagt caatgtttct caaagtatgt tccacagaac
190861 attagttctt caggatgtta atagaagtta catgagaata aggagatgaa accaaataaa
190921 tttgggaact gatgggctac gcaaaggcaa gtgacttcct ttcagaattt cagagtgtgt
190981 aatgttctgt gtgctcagtg aatctccaag Rgggagatag accaggcagt gtttcctaag
191041 cttatctgta gattcttctt ccccctaggc caggggctga caaattatgg ctcataggcc
191101 tcatctatcc caccactttt tttttgtaaa taaagtttat tggaacacag ttgtgcccat
191161 tcatcgtatt gtctgtagct gctttagcac aacaggagag ttgcagagtg gctacagagg
191221 tagtctggcc ctcaaagcct aagatattta ctatctgccc attacagaaa ggtttgctaa
191281 tccctgctct agacaattca tggaactggt gcttcctggt accccctttc agagatgcta
191341 ctagaagaag atatacatgg gttgttctag cactgcttta tgataaatct gcctcatttt
191401 attctgtttc catactgcca tcattcctgc ctcttgcttt aaactacttt atctctcaac
191461 catttaccca ttatccagga tccaaacctg ggttccatgt gtccttatct tttcttgcac
191521 tcacaacatt ccaaaaatgg ccaagggtgt cttcaatttc cagtctgggt agctcttaag
191581 tcagcccgaa cccattccta ccaacctggc ctacatgacc gtcatctttt ctttttcagc
191641 attcgaatta ggttcctttt ccccagatat gagttacctc tagtcctttt tactcactga
191701 atctagaata acctttgtaa aatacaaatc tagtcagatt gattccttac ttaaaatcct
191761 tcagtggtcc ctgtggccct caggataagc tcagatcctc aggatggatg tgtgtcagtc
191821 tggttgggca aacagaaact actcctggta tttcgtactg gaagagattt aatttaagga
191881 attagttact taagaaaagg agtagatatt tccaggcttc tgcctgctgt ggcatagaga
191941 agggcatgga aatgggggat ggtgttgagt gtttagcaaa tgacccagaa caaaccaggt
192001 ctgggaaacc atgtgttatc ccctgctgcc cttctccagc ttcagctctc ccatttttct
192061 cctgactcct cacccttcct ccaccctgca agtccccaaa ttctagatat atcaggatgc
192121 ctttttgtcc ccccagaaac ttaaaacaac tgacatttac gaactcacag tctctttggg
192181 tcaggaactt gggagtgact tagctgggtg gttcggggtt acatcctctc atgaggcttc
192241 tgtcaagatg tcttccaggg ctgcagtcat ctgaaggctt aactggagct gatgatccac
192301 ctctaagatg gctcactcac agggctgttg gcaggaggcc tcacttcttt gctgtatgga
192361 ccccttgtta ggactgcttg ggtgtcctca caatgtggca gctgactgtc tccagaacaa
192421 gtgatatgag agtgagagat agagatagaa acagagacaa caaggaggag catactagag
192481 tgctttcagt cccctctcct gggagtacgt tgcatagtgt ctcaggtcag cttccctaga
192541 agcagaaccc tgagatgagg attcttcaaa agtgatttgt tgaaggagtg ctctttagga
192601 aaaaacctag aaggaggaga gggaagaaaa gtagggaagg ggaaggagcc aagcaatgat
192661 atagtctcag ataaaatctg accttggcct gatccacaca ggcaggattc tggtacataa
192721 ttgcataata gagttaaccc tgtttgagac aggggactgg ccttttatat ccttctctaa
192781 gtcagtcatt ataggctgct ggaggtgggg gtgggaggta ggctcccatt agttgagaat
192841 aagtctctag agaagagggt ggctgtgagt cctcagtagc taacactcag agcagctggg
192901 ggatggtgtg ccagccaggg aaaggtgacc caggtggggc caacacagca cctactacag
192961 tgggcctccc cRtacccatg tcccaagcac ctaccatggt ccctgacata ccagaggtac
193021 gaaaaaaata tctgtgtaat tgaataaatg aatgcataga aatgcttagc ctctctggac
193081 ctgtgtccat ttctgggaag tcagctcagc agggatcata ttgtcccatc aaccatggga
193141 atggtcgaag acccaggaca gtttgccaca tcatgagtgg cagcactgtc taagtccagg
193201 attttcattg caaaattaga gtgaaagtat atttgccatt tgtgaataag gaagtattaa
193261 tattacaata ttatatattt ttaaaaggaa ctttagctca catttcagtg agctctttgc
193321 taaaagtaca ttttcctggt ttgtcacatc ctgactgggt acatgttgtt acacatggaa
193381 ccgtgagggc agaactgcca tttgttatat taattgtaat ccatatatct gtttttttcc
193441 cacaagaatc agtcactgga tttcagttca gaaaaccaaa actgtcggac aaagccatat
193501 tatcgtgttg gcagagttgt tccccatgac cccaaataca cagaggagga agagaaccac
193561 tgaggcccct tgttttcttg gattatcatt cttccaaagt tggtaactaa gaaaagtctc
193621 aagaaatagc aaagaaacct ccccacctta ttctgctttc cacatcccaa gcctaacata
193681 agcctcaaac tatttttatg aaggaaagct tattgtgaag agggtctttt acatgcctaa
193741 atctcatctt tagtttttct tatcacacag ccggttatct ttgcccatct cttttcctgg
193801 gataatgtct ggctctgtca aggctgtgcc ttattctggg accttcctaa tgcctgtgtt
193861 ccaggtccct cctgagattc gctcctccga atgcttgata gatggatcaa tttaggggat
193921 tgatggtcag atttagcctg acataacacc atgcagtggt ctgttaccag acatagagct
193981 ggaaaaccca ggcccttgca tacaagttca ggaaggtaaa tttgcaaatg aaaaacattt
194041 taagacacat ctcacagctg cttcctcatc ccccacccta ttgtttgtgt ttttagagat
194101 gtttaagaga aaaggaggca ataacaaaga cgctctgctg tgctttggaa tcctcattta
194161 tgttgaaaaa gggtccattt atcatctcct tggatatttc cacaaggaga ctttgctcat
194221 ctcaccaggg aatggagtgg tagagcaaac acttctctgt ccacctgatg atggaggaga
194281 accaactaac tgaaaggcag agagcctgaa attattatcc tctctctgcc tgcctgctgc
194341 aagatattgc tgcatacctg tggtccctgc aggaggctgc atgcgtagac ttgggccaga
194401 acatatatta ccttccaagc aatagatttc taggtaaaag gcaagaaggg gcctcaggtt
194461 caagttgcat tcttcagtgg ggttcacagg aggccctgca ttcagggggt tactgggccc
194521 tccttcagct gttaataaaa ctgacttttg gctcatagag cttggagtat gcgtccattt
194581 gtatgaacct ccagggaaag cagggtgagg gcttgtgttc cctagactcc tggcagtgaa
194641 tggctcctgg acagctttgc ttggttgttt cccaggtact tcaaactcaa tctgcctaaa
194701 gatgagttcc ccctcactcc tgcttctcct gtgtttccca tcttggggat tgaccttagt
194761 gttcttgtgg tagccctggc tgaaattatg gatgttggag catgggaggc cctttgtgaa
194821 cttacttttg ggtctttctc accattccca cacattgctc ttttagccca ggcctcagct
194881 gagacateac ctgctcctga gtctttgccg acccatgaga ctgggtgctt ctgtattccc
194941 catacttgcc ctccacagtc cactgaagca agttggcttt gtcacttccc tgttgctccc
195001 actagacttc aagcttctct taagcaggat ctgtatcttg ttcatccttg agtgccagtg
195061 ctagcacagg gcctgcctgt agtagctgct taataaatat gtcttgaatg agtaacactc
195121 aggcctgaga atacNtgaga ctgtatggca tagtggttat aagcttagct ttggaaatca
195181 aggcctgtgt tcagactctg ctatttgtgt gattttgggt gagttcctta acttcttgat
195241 cttcaatttc ttcaccaata agatggggat aataactact tcctagggct gtgatgatga
195301 attgcaatga tccatgcaaa gccctttgat caatgtatga cacatagtaa gtgttgtgtg
195361 catcatagta cctattagta acaacaacaa caatatagtt atcgttaatg gaagggagaa
195421 agctataaga actagttgga actagaagtc aggaatattg agtgcttgca tagtggattt
195481 agaggagatg gggaattgct tgggataaaa tgtaggaaca gatgggatta ccctgggaga
195541 gaatgaacag ggagggaaaa atgggtggag caactaaaga cagaaccttg agaaatccta
195601 catttgaggg ataagaggag tcaaaacagg aaaaagagtg aatgactaca gttaggagat
195661 tgcagcttct cagatgccag gggcaggagt ttaaaaaaga tagtcaaagg tgctatactg
195721 ggcagaagat caatgaggag aagacgagaa gaggtagcca taacgtgtta aatgggggta
195781 tgttagcgcc cttgggaact agccatttca gtggagtcag aggaagaagc catgctctga
195841 aggaggttag agaaggccac gttagggatg aagtgggcat actaagtcag tttgttgtgc
195901 tacaatgtgt gtttctgtaa tgaggattat ctgtgggtca gtagatgact ggtgtcagta
195961 tgatgtagaa gtcacattgg ttcatatgta gggttcattc tcagcacatg aatgttttgg
196021 catcactggc tactagtggc tgaaagcaga ctaacacacc tgaaggcaga agactggggg
196081 aaatggggga catagagagc tgctcatgag gcgcagtcac cctgtgttct tccacttgac
196141 tgattggcac ccactctgtc ttgaagtgct ttggggacat tccttgccaa tcttggtgag
196201 tttagtcact gattccattc cactcagcac ccttgaccct tctgataact ccttcgacca
196261 cagtcYccct tcctttttta agaagggcca tatttactag agtttttttt tttttttttc
196321 ccaaactgtg tccaggttta ttaaagatac tttttgtgaa cagtcatggt atttcaggca
196381 ggacatgagc gacaatcatt aacagtatac aactttcaga ctccctcctt caatggactt
196441 ccaaaatcag aaagccatgg taaaacccaa tgaagtcttc atttggtacc ctgaagaggg
196501 aaagttcaga gtgagggttg acatttcaca ttcaacgtgc tgtttaacaa cttttcatga
196561 gctgaccctg actttcagga aatgaaatga aaatggcaga atttatctga agatccacaa
196621 tctagaaaca gagcacgtgt ctttcaaggg ttctcgctgg aaagtccaga ttgccagcct
196681 gactggtaac cagttattgg gggccagacc ccaacaggta tctgggtttg agggagttaa
196741 gtgtatactg aaggcagaga gggagagggg gaaataaaga ggaatttgtt tctccacacc
196801 acaaggcctt tgtgcgaagg tgactgtgtg tgtcaacgtc agacagtccc tctttctggg
196861 agccaagaag atgtctttaa aactagaagg gaaaggtgtt ttctccacat cagtccagct
196921 tcatagacat tctttttctt ttttttcttt cctgagacga agtcttgctc ttgttgccca
196981 ggttggagtg cagtggcacg atcttggctc actgcagcct ccgcctcccg gcttcaagtg
197041 attctcttgc ctcagcctcc tgagtagctg ggattacagg aacccatcat cacgcctggc
197101 tagtttttgt acttttagta gagacggggt ttcgccatgt tggtcgggct ggtctcaaac
197161 tcctgacctc aggtgatccg cctgcttcgg cctcccaaag tgctgggatt acaggcatga
197221 gccacggtgc ctggcctcag agacattcta ttagtgacat ataccccttc tccataaaac
197281 aacaatgacg tgttccgtgt gctaacaaca tggcttaaaa taaaggcata aaaacaattc
197341 tgcattttta taaaacttaa taaaaaaata atacttcaaa ctgcacagtc accagaaaKa
197401 cacagttatc aaaaatgcac acacttccct tggcatcccc agcgccttca actttctgtg
197461 cctgctctgt tttggcctct gcattttctg cagagttatt cccctccttg ccagcatggg
197521 ctttttcctt tttccccttt accttctctc ccttctttgc aggggcctct ttaggcttgg
197581 gcttcggagg agcaggtttg gcagacaacc ttgcagatct tctctgtggt ttgtccttac
197641 tttggtttta tctcctttag cgtccccttc agcctttctc ttgggcatgg tggaggcgac
197701 tgcagtggaa tgtaggtgct ggatctgggg atgcagcagt gcgtgggctt tggttggcct
197761 gggggatagt tcttacctct tcttcttcac actgctcata gagtatttct ttattagaaa
197821 tttaacattt aaaaaattca gtgtttttaa tgatgttgat tgtttttgtt ggtgctcaag
197881 ttaaaatctt tgttttcaac cctgtttttc cgataagcct tgttactttt agagtttgtt
197941 gttgcgaagc attagttttt tagcaataca tatgttcaat tacagaagaa attcccatga
198001 ttccttttcc taaggttgaa caatctggga aggagggatg ggaaggttaa tagcagcatc
198061 tatgggaggt ttttcccaag gatcagcaga cttaagcatt cttggctgca acttggccta
198121 aatcagtttt cccttggtga ctatcttcct aagtgctctt tattgtatat ttaggtgatt
198181 gtggttttgc atttctgtcc tctctctgat ctcttgctac agtctgaaca agtgtcggag
198241 gccgagttac tcccacagct gagcagagcc ccatcccagg ctgcagaaag tagtccagca
198301 aagaaggtaa ggtcagcctg aggatgctgt cagatggcgt tgcgagtccc accccgggct
198361 tcttatctct attagctgat ctattgtttt aaggtttctg tgtcctgaaa tgaatgtcaa
198421 tgatccagat ttcctagaat gtgggttctt tgtgaagatt ggggtcctga agattcctgg
198481 gcttgaccct tgatgcattt tgtacatgac agtacatact caacctcctt agccccccag
198541 ctaaacatgg tggccttgtt tatggcaaga gctaaaaggg ctgtggggag ggacagatgt
198601 ctttagcaaM accccatcca cctgctaagc ctctgtgaat acctcttggg gtggggtagt
198661 ctctcctttt tggtctttgt accatggttt cctcttgcat cgtggcattt tcacctggca
198721 tctgcccagc catgccattg ggtcacctgt aatttgctca gtaagtaccc ctcactcatc
198781 atgctctcca ttcatctcct caccctcttc ttgtccttct cccaggctct tctttcagag
198841 agagtgggcc Ytgggctcag gagcacaggt gaggtagagt cctccaaaga agcagaccaa
198901 ctgtgtcctt ccagaataca ctgtggctct ttttcttgac tttatgtagg aattggggat
198961 aggagaatga tgagcatatg actaagacct ttaaaaactt ccaaagctta ggtttttttt
199021 tgtttttgtt tttgtttttt tttcctgaga cRgagtctcg ctttgttgcc caggctggag
199081 tgcagtggcg cgatctcggc tcactgcaag ctcccaggtt cacgccattc tcctgcctca
199141 gccttccgag tagctgggac tacaggcatc ttccagcagg ccggctaatt ttttgtattt
199201 ttagtagaga cggggtttca ccgtgttagc caggatggtc tcgatctcct gacctcgtga
199261 tccgaccgtc tcggcctccc aaagtgctgg gattacaggc atgagccact gcgcccggcc
199321 aaaatttagg tttaaaaggc ttcaaagtga ggcaggagcc tatcttgtct tcagttagga
199381 aaggccccat ggtgtgagat gcacacaggg tctgtgtgag tttcaggtga caagaagtaa
199441 tagacttctt gaaacattta aaaagaaaaa gaaaaaaggg aagaccactg gactctgatg
199501 cctgtgtccc cccagttctt gctgagccat gggtcagtaa atagagtacc ctcctgatct
199561 tggggttggg gctaaaggca tgtgggacac tggaaggaag agtggaggga acattgaaat
199621 gtttaacttt ttaattttta ttttgtttta aatccacagg atgtactgta ttctcagcca
199681 ccatcaaagc ccattcgtag gaaattcaga ccagaaaacc aagctacaga aaaccaagag
199741 ccttccactg ctgcaagtgg gccagcttct gcggcaacca tgaaaccgca tccaacagtc
199801 caaaagtaag tagaccacat aaacaagagt gaggtaggaa tctcgctctg agatgtcgac
199861 ggatatgtaa atgtgttgac atttacgtgc gcaccaacag aaggatttca tggttgtaag
199921 tttatcttgc tcatctctgt gatgggattc aagtctccca gtcacataga aggctttata
199981 agctatagga cttaacctga cctaaagggg caggcgagtc ctaggctgtg gtgtttggtt
200041 tggtttgatt tctttccctt cctctcacct tctgttgttt cctactcctc ttccttgtga
200101 gggcccaaat tttcctggca agatgaaagt attgtaagtg gcaattttgc ctctctgcct
200161 gtgttatctc cttttccttc agggcaaatg gctagctcct tcacccacag acacactttc
200221 agtaggtgtg gtatgtgatt cttttaaaat ctccgtaaag agtttctgtt gttggtcgcc
200281 tcagcacaga atggatacat gcagaacttc cattatattt atctaaccag ctggaacagg
200341 tattggaggg agggtgaaga cacctgtgga catggccagg gactgagaca atgatgctct
200401 ggacaaacta tccttctctg taaaactttg gctttgagaa gagccatcac ttgcttcaat
200461 ttctttgtag tgaaattgag ggaggtgttg aggacagaaa cctgctcctg tcacttgact
200521 gcaagtgagc ctgaccggtc actaacataa atgctcaaga cccatcatga ccctgctttt
200581 ggggtcttgc aggtctcaga tgctgctgca gattttcttc tgcttacacg ttgtagaaYg
200641 aaaagcagca ggttctgtgg gagatgttag caacttgtct ttgaagccaa agtcccattc
200701 tgaatctctg cagccctctc cttcagaaga ttttcttttt ttcaaatgga caggtccctg
200761 gtggtatcag tccataaagg aagtatattt tgttcatcac attcaccgag aactttgacc
200821 atcttccagc ccctgttaag cctggaaggt gaagaatccc tatcagggac aaagatggct
200881 caattttctt ccatgttcta ccccagcact ccactttaat ttcagcttta tgttcatttt
200941 agtcagcagt ggcttaacag tctccagagt agatgtcagg gcatctggtg gagttcatac
201001 agagatcttt tctttttctc ttttttataa cagctttatt gcaatataat tcacatagca
201061 tacagttcat gtttttaaat gtacaattca gtggttctta gtttattcac aaagtcatgc
201121 aaccatcacc acaatctaac ttttgtcatg cctaaaataa tatatatcca cgcccattag
201181 caatcactcc ccattctctc cttccccctc agcccctggc aaccacgaat ctcctttctg
201241 tctccatggc tttgcatatt cttgtcattt cacataaatg gaataatgaa acgtggtctt
201301 ttgtgactgg cttctttcac ttagcataat attttcaagg tttatccaag ttgtagcata
201361 aatctgaact tatcttttta tggctgaata atattccatt gtatggatag accacatttt
201421 attcatccat tcatcagtca atggacattt tggttatttc tgcttttttg gctcttaaga
201481 gtaatgccac tatactgttt gtgtacatgt ttttgtgtgg acttacattt tcatttctct
201541 tgggtctgta cctaggagtg gaattgctag gtcatgtggt aactctgtct ttaatatttc
201601 gaagaactac cacacttttc atagtggctg caccatttta tgttcccgtt ggcaacgtat
201661 gagggttcca atttctccat tttgtcaaca cttatctttt ttttttatta tagccatcct
201721 agtgagtgtg aagtgtgatc tcatggtttt gatttgcatt tcttttgtgg ctaacgacat
201781 tgatcatctt ttcatgtgcc tattggccat ttgtttatct tctttggaga aatgtgtatt
201841 cacacccttt gcccactttt aattggatta ttaatctttt tacttttgag ttatgaattc
201901 tttatatatt ctggatacaa ctcccttgtt agatatatga gaaaattgag ccctctttgt
201961 aaatattttc tctcattctg tgggctgtct tttcactttc tattttttat ttttattttt
202021 tagagacaaa gtctcactct gtcacccagg ctggggtgca gtagcatgat catggctcat
202081 tgtagcctcg aattcctggg ctcaagtgat cctttccccc tcagcctcct gagtagctgg
202141 aactacaggc atgagccacc attcccagcc aatttcattt tattttttat agtgatggag
202201 tcttactatg ttgcccagtc tggtctcaaa ctcctggcct caagtgatca tcctgcctca
202261 acctctcaaa gtgctgggat tacaggcctg agccactgca cccagccaat tatcaatatt
202321 aatcagatct gtacagtggt cacagtccat tctagttcag ttgctctttt ctagaaccta
202381 tctcccagta atggcacata tggctgtttt tctaggagaa catcagttgc tcttttgctc
202441 taagaattcg gtgtttcttg ctgtgggatg aaaggttgta gattatccct gtggtaactg
202501 cactgattta tcatcccaac catggacggt tttgaaaagt aaagagagtg ctaatgtact
202561 tatgctggac agacagtttt aaatggagac tgtaatgggc gcagtaggat gcgtggtcac
202621 tctggttatg cgtgttctgt gaatttgttg ttaattggga aatactggta ttaaaacgtt
202681 ctgtattttt ctcaagagcc acagatatat gctggtccat gcacatacac gagtgcacat
202741 ttatgcacac acacacatat acttaggcat tcatgcctaa taatacataa ggtagaggta
202801 ggtagtctgg ctaagttaat gtagaatttt tgctaaaaat aatgttcttg tattattttc
202861 cttcagactt gttcacaggg gacacctgca ggtcttctaa gtgctattaa ttcttacaca
202921 aaaagggcat tccagttaat atggtttgtc aggaagaaat acttattaaa atgtcttgga
202981 ataaatggaa cacaaatgtt tgaaaaggcc catttcacag cttttattca agttataaaa
203041 tgggaattac ttcaggtgta aataattcat cccaataaat ttgtttcatt tggtgtctat
203101 cttcctgacc gcctgtgaat atgagatttt atttttggag ccctgtgttg ttaaccactt
203161 gttagtttaa cacctctcat gaatcagagt tctgaccctc aagggtccag acctctaagt
203221 cctttttcac tgaagtgttt gtgcttttct ataggcagtc ttccaaacag aagaaggcca
203281 ttcaaactgc tatccgcaaa aataaagagg caaacgcagt gctggctcgg ctgaacagtg
203341 agctccagca gcagctcaag gtaaggaatg agtcccagat ttggatgacc aggcttttcc
203401 ctggctttta aaaagctttt ttttaattta ataggcatat aataattgta catatttata
203461 gggtggggta catagtgatg tctccatacc tatcatgtac agtgatctga tgtgtccatt
203521 ggctgaccat ttagttccat ccctgttgat aagacttgcc tcttcgttct caaacccttt
203581 ttggaaggtg gagaattact gtatttaagt ttcatgggtt ggttcttgca tagtcagagg
203641 aagactagtg actttaatat gtaggcttca tattgtgtat gagttaaaag gaaagacaat
203701 ctattacgaa ggctgtttga agcattcttt attatccaaa gcttctgggt aagcccttaa
203761 ttatttacat cctctctgaa agaggatgta aatacttatt tcagtagaag gaagtcacct
203821 tggtactatc aaagcccagc ccctcctctg gtgccttgca aatggttcca tttcaccttc
203881 tcaatgacat cacccctgtt tctcttcatc gttactctcc cctgtgttag tttctcgggg
203941 ctgctataac aaaatactac aaatgtggtg gcttaagata accaaaaatg attctctcac
204001 agctctggag gctagaactc tgaaatcaag atattggcag agctatgatc tctttgaagg
204061 ctctagaaga tgatccttcc ttacctcttc ccagcttctg atgttgctgg cagccctggg
204121 cattccttgg cttgtagctg cgtcactcca atctctgcct ctgttgtcac atggccttct
204181 tcctgtatct ctctgtgtct gtgtccaaat ttctcttctt attgtatcct cttataagga
204241 caccaatcat tggattagga cccaccctaa tctagcatga cctcatctta acttgattac
204301 atctgcaaag aacctatttg catataaggt cacatttaca gatactgggg gttaggactt
204361 aaacatatat tttgagagga catgattcta cccactatat cccccagttc tctactggat
204421 cattcgccat ccacatgtaa atatgctcca gtattgtcca ttacacttgg ccaattactg
204481 cctcatttct ttggtcccct tcacagcaaa gtttcttagg agtggtttta ttcattatct
204541 ttactttcaa accagtaatt ttctcttcct tccacttcag ttggcttcgt cctcctccac
204601 tcacacccgt cttgtggcta aatccaatag ggctgtttta atattattat ttttttttca
204661 gaagaattct acacaattga tcatttcctc ctctgaaatg gcttttataa ctggtttttg
204721 acataccata ctctcctggt tttccttctg cttcactggt gcttcccatt ttcattctct
204781 gctgtctctt ccttccctga cttaactttt ataccccaac cccatttgcc ccaatatttt
204841 agtatgaaaa ttttcaaaca tacaggaaag ttgaaagaat cataagtgac tgcttgtata
204901 gacatcactt cagttctaca ataacatttt actatactta tttttaatca catatctacc
204961 catttatcct tgtgtccatc agttcatctt atttttgaca tattttcaaa taaattgcag
205021 atatctgtat actttccctg aatattttag catgcgtata attagctaga gttcaatata
205081 tttttacagt tttttcttat gatgtaaaat gtttatacaa aatgcatgca caaatattat
205141 tattattatt attattatta ttattattat tattattatt attatttgag atggagtctc
205201 gctctgtcgc ccacgctgga gtgcggtggc gtgatctctg ctcactgcaa gctccgcctc
205261 ctgggttcac accattcttc tggcttagcc tcctgagtag ctgggactac aggcgcctgc
205321 caccacgccc ggccaacttt ttgtattttt agtagaggtg gggtttcact gtgttagcca
205381 ggttggtctc gatttcctga ccttgtgatc tgcccgccta ggtctcccag agtgctggga
205441 ttacaggcgt gagccaccgc gccagcgcac gcacaaacct taagtgtaca tttgctgagt
205501 ttgtaacaag tacatgtact tacggaatcc aaacccccaa aaagatagag aatattacca
205561 tcaccccagg aagctccctc atgctttttc ctagtcaatt cctgccctac ccacacagag
205621 gcaatcacta ttctaatttt tataccatag ttttgcctgt tctataactt tatataagcg
205681 gtgtcttaca acttatactt cttgtaaagc ttctttcact aagtattatg tttttgagat
205741 tcatttatat tgttgtgtgt atcagtaatt cattcatttt tattgatgag tagtatccca
205801 ttgggtgaat atgttacagt ttggttatca attctattga cagacacctg agcggtttcc
205861 agtttttggc aatttggaat aaaactgcat tttttaataa gtctctgtat ggaaatatgt
205921 tctcatttct cttggattgg gattcgtagg tatcatggta agtgtatgtg attagtttct
205981 gagaaactgc tagatcattt tccaaggtgg ttgtagcaat ctgtactcct accactaatg
206041 tatgagagtt ccaattgttc cgcgtctttg ccaacatttg gtgttatgat tcttattaat
206101 tttagctagc cctgtagtga tatagttttt atcatctcct tgctgactaa ttatgttgtc
206161 cacttttctt tgtgattatt tacctttcat atcttacttt atgaaatatc ttttcaaatg
206221 ttatttttct ccaaagtagt ctatagattt attacaaaac caataaaaat cccagcagga
206281 ttttttgtga gtatagacaa gctaatccca aaacttatat gtaaaggcca aggagctgga
206341 attgcttaaa caaatttgaa aaggaagaac aaagttggag gaatcacttt actgtcaagc
206401 tccagtaatc aagatgctga tgcacaggtc agtggaatag gatacagagt cctgaaatag
206461 accacatgaa aacagccatt tgatctttga caaaggtgca aaatcgattc aatgagaaat
206521 aatagttttc aacaaattgt tttataacaa tttgtcattt gcatttaaaa aaataacctt
206581 gatctaagcc tcacatctat acagagatta acttgaaatg agtcatagat gtaaatgtaa
206641 aacatagagc tataaaattt ttagaagaaa acagaaaaat cttcatgatc tggagttaga
206701 aataacacca aaagcacaat ctataacaga gaaaaactaa aaaaattgga cttcatcaaa
206761 attaaaacct tttattttgc caagcacagt taagaaaatt aagagacaag ctgctgagtg
206821 ggagaaagta tttgcaaaac acgtatttga taaaagactt atatctcaat tatataaaga
206881 actcttaaaa ctcaataata agaactctca aaaccaaagc atctcaattt aaaaatgggc
206941 aaaggatttg aacagacact tcactaaaga atatataaag atggcaaata agtacatgag
207001 aagatattca acatcattag ccatttggga aatgcaaatt taaaccacaa ttacatacca
207061 ctatacacat actagaattg ctaaaacaaa aaatgtgaca tcaccaagtg ctggcaatta
207121 gaactctcat ttattggtgg tgggaatgca gaatggtacc accactctga aaaatcgttc
207181 agcagtttcc tatgaagtta tacatacact aaccatgtga cccagctgtc tctctacctt
207241 agtgaaatga aaatttatgt tcgctcaaaa atctatatat gaacttacat agcagtttta
207301 ttcatgatag cccaaacctg gaaacaacac aaatgtcctt caaaagatga atgaataaat
207361 tgggatacat tcatacaatg gaatagtact caacagagaa aagaaatgat acacaacttg
207421 gatgaaactc agacattatg cagagtgaga caagccagta tcaaaaggtt gtgtactgta
207481 tgattccttt tatttgacat tcttgaaaag gtaaaactat agtgatgtga aacaaatcag
207541 tggctatcag gggttatgca tgagatgaga gtttgtatga gtagtcccag ggaacttttg
207601 gggttggttg aactgtaatg tgtcttcttt gtggtggtgg ttacacaaat ctgtacacta
207661 aaagaaaaaa attgttttac cctatgataa ttttaaaaag ttatttttta aatttcaaag
207721 ttcattctgt tttctaaaac tttgtatgtg aacttgtttt gttttgcatt ttgtttggtt
207781 ttggttttct cctctctccc tctgctttgg ggtaggccag tttcatccat tgttctctac
207841 atttggtggg cccttttgga aactgatatt ccccagttct gaagggtttt ttattttcat
207901 ttttgttgtc gttgattatt tcctcccccc tgccctcacc cccatttttt tctcattctc
207961 ccttactgat attcagacat tggacttctt agcttagttc tctaattttc tcatattttc
208021 tcttctgttt tctttctttt ctcttcctac attttcttct ttatttttgt ctatttctgg
208081 aaacttaatt atatattcta aatcttctgt tgtttaataa ccaataattt tttgttctct
208141 gtttattttt gacggtatcc tattcttgtt tcattgttgt gatctttttt ttaattatac
208201 tttaagttct gggaaacatg tgcagaactc gttgtgatct ttttttatgg tcatttttct
208261 ttcttcttcc tgaatagttt gtgtttgttg tgttgtgttg tatgtgcttt atcttagatg
208321 ctttcctttg atatctgatg gcccttcttt gctcatattt aaaaggaaga tgaaaacact
208381 gattagaagt tcattgtacg ttgtaaggct tgtcaactct gagcttcact gtctggcaat
208441 ttggctcggc tgtatagttg gggaaccccc aaagggagta tgattagctc tttcctcttg
208501 gtctggttgg agtgtccaga gtggagactg ttttggtcac ctacatggag ggatagagtt
208561 ggttcagtgg agcaagaggg ctgtaggtct cagcattcca ggatattcat tcactctccc
208621 tatttctggc ccagtatctt gtcctcaact gtgcttgttt cttgctaatc cagatgctct
208681 ctgttgtacc ttttcaagaa ataaaccttc agcattctgc cctggtggca ggaatgatct
208741 ggggatctaa ttgcttctga aacagatttt cagccaacac ttattttagc caactcccat
208801 ctccccttat gtactcccac tttaataggt atctggtgtt gccaatttga gtctttcagg
208861 aattctccta cgtaaaatca agttggttct tatttttctt catgttagcc tgggactcag
208921 ctttctttac ttgatctgta tgagtggaaa agttctaagt ctagtgaaca gaagtctgaa
208981 gaatcattga aacagaacta tagtcatagc ccctcaatta attcccaggc taagccagtt
209041 tatagatcca gaacctcttg aatgatgaag gggcatctat gtctccttaa ggaaggaccc
209101 cactgtgcag ccaaaaattt acactgcaaa tctttctcct agcctttcct aagggggacc
209161 ctgctgccat ttaccagggt gactgtgcat tagaggaagg gaaataatta gacttttggg
209221 gaattaccag acactggctc tgaactcaca ctaattccag gagatgcaaa gtgtcactgt
209281 ggcccatcag agttggggct tagggagatc aggtgatcaa tggagtttta gcttaYgttc
209341 gtctcacagt ggacccagtg gactcccaaa ctcaccctRt ggttatttcc ctagctctgg
209401 aatggcatgc ttggaataga catactcagc agctggcaga attcccacat ttattttcct
209461 ggatttccta agtcatttac cattcaccag tttgccactc agctttcaaa ttttattgct
209521 atcatcttgt cccttttgtt ttccctgtct tgtgggtccg tgactttgaa aagttgctgt
209581 attgttttag tggtgctcca ggagggagag agtgtggtac ccctggtcag tcttccatct
209641 ttacctgaaa cctctatcta tactgttttg ctagatgatg ttatatggtc tcatggcttt
209701 gaagaccatc cataaactaa tgaaacctaa tttatgtctc aagccctact tctcctttcc
209761 tctgtgctct agacttgcat atataacttc ttactcaatg ttttctcctt agatatccaa
209821 tacacatctc agataattaa ttgccaaccc tctccttgaa atactcattt cttatctaat
209881 cttctcattc tcaatatcac taccagccag ctactttctt catacaaaaa tcccaggagt
209941 catcctcaga tttttcttct ctcctacatc aactttatca gcaagtccta ccagttctag
210001 attcaagatt Katctagaat tcatccactt ctcttcatct tcatggcttc taccctgacg
210061 gaagccattt tcatttctca cctgggtccc tgcagtaacc tcccagttgc tcccctgctt
210121 ccactctcat cctgctataa tctactgtct acacagtagc cagagtgaaa attttgaatt
210181 ttaagttggg tcatgttcct tccctgatta gaaacactca atgccaggcc gggtgcagtg
210241 gcccacgcct gtaatcccag cactttggga ggccgaggtg ggcagatcac gaggtcagga
210301 gatcgagacc atcctggcta acgtggtgaa accccgtttc tactaaaaat acagaaaatt
210361 agccgggcgt ggtggcgggY gcctgtagtc ccagctactY gggaggctga ggcaggagaa
210421 tggcgtgaac ctgggaggcg gagcttgcag tgagccgaga tcgcgccatt gcactccagc
210481 ctgggcgaca gagtgagact ctgtctcaga aaaaaaaaaa aaaagaaaga aagaaaccct
210541 caatgccatc cccSctacat ttccatacta tttcctctgc ccacaaggcc ctgtacgatc
210601 tggctccttg cttaaatctc tgacttcatt tcctgccaat gtcttccttg ttccatctac
210661 tctggtcaca caggcttttt gttcatcaaa ttcaccaaac tcactcgctc ctcagggcct
210721 ttgcagttgc ccttttgtct ctgtgaatat ccttcccccc atatcttcat atggctcact
210781 cctcatttca ttcaagtctt tgctcaagta ttgctaactc tgagaagcct tcccagggca
210841 ctctctctcc tttctcccat atccccctct gttactctct attatgttat cttatttcct
210901 tctggaagta tcttgttcat taactttatt atctttctca agtcatttga atataagccc
210961 tattgctctg atctggcata ttctttgctg ataccatcac agctacagca ttacctcacc
211021 tgtaggagat agaaaccaag agacttccgg ctgggtggct aggagagcat gtgaataaat
211081 acttgtgaag ttgtatactg actattagta tgctgattct tctgaatctc acaattcagc
211141 ctttctacag gattctttcc caccttgact gattctactt gaataccttt atgtgtcccc
211201 tctcttcctg ccaaaaaaat ccgttttagg cccgaaagtt tgaattccca aagagcagat
211261 tgdtcagcct dttttctgcc tttcacccag atgttgtacc ttacaccata tgttgtgcag
211321 aaacttggat gagactttgg tggaggggca actagcgtac ctttttggcc ctcagaccta
211381 actgagtatg gtgcgggatt acgagccaga gattgcaact agaaatttaa gtcctgttgg
211441 ctcactgctc agtattggga gtctgttttt gctttctgct ttctcctagt cttttaattt
211501 ttaatgactc tgtctaccag ctactgatct tgtcaaaaca ggctaaaact agggcagggt
211561 ggtagagggg agtaggtcag tttcatttca tcacgttcag aaaggagttg agagattaca
211621 aattgtgaag ccccttttgt ctggtcacca gcattaaatc tgatacctcc cagtcctcct
211681 gttcttgagt tatacagcac ttgtatttgt gggtccagtt ataagtttcc ttttaaatct
211741 gatgaagtag ggatgaattc aagaaatgac ccctttgctt ttttgttttt cttgtgtttt
211801 gtacaactca ggaggttcat caagaacgaa ttgcattgga aaaccaattg gaacaacttc
211861 gtccggtcac tgtgttgtga cccccccatg gttcaagtga cagtgggtga ccttgtctgc
211921 caagatcttt cttttgaatg ttttgaaccc aactacttgt catagatgtt tgactgtgtc
211981 aaaagctgtg agcagcaaaa tataatccat atgacctttt ctcttgcact tcacttgtat
212041 gttttactgt ggtggaaaaa atacttcaac tgattatcac acttgaaatg ctaattatca
212101 gtggaatttg tctcctattc ttaagtactt ctgcaaggta ttagatgctg ctccttacca
212161 aaaatcagtc ttctagcaaa taaaaataac ttagagcatt atttatttaa agaatttatg
212221 ttttctataa aaccttataa ccaagaacct tcaggatgct tgtaaccaag tactttcagg
212281 atgctttttg tatgtatatc acatagagta ggttggtttc ctgagtaatt gggattccaa
212341 ctagatagtc attggtgtga ccataataaa aacaaaagct aaaataaaag catcagattt
212401 agactggcgc tgtgccctct accactatat gccaaaaatt gcttctctag tgccattttg
212461 atattatatc tagctataaa taatacatga ctatcgtttt ctattgaatg tcaaagactt
212521 actgggtctt tacacctctg taaagtggag gttttggcaa tgagctgttt aacttggcca
212581 agctaggctg tcaacccaga caactcagtc ctttcatgta aatttttggg caagagaagt
212641 ctgctttgac tgccttgcct gaccaaatta aataaatagt tgccagatct ctacttttat
212701 cctgcatggg ataatatatc tgtaaatgca tgagtttgga aaccacccat caaatatgaa
212761 aggctgatga gactgttagg attgataaac atttgttgtt tgaacccagc tatccaaact
212821 ggggaagaag gggaaatggt tgttaccaac aatctctagt agttatttta atctttattt
212881 taacctggat tgcaaatgta tggggtatga ggagataatg aaagaaaagt ggtcctcatg
212941 ctggatatgt gactgttttg ttctctgtaa agtgtattct tgggaagtga ttggtttata
213001 tcagattcag aggagcccaa ttaactccag tgtaggtaat gtaaaacagt aagctcaaat
213061 tgcagaagcc Rgtatcctac agaaatttaa gtagctactg cttctcctga aagcccaagt
213121 tgaaaatggg accacagggg cacagggcta ctgaccctca cagggcatgc cagcgttaac
213181 accactttga gagaccaatg gcaagaaatg ctgtctcttg tgcattttac taatttcccc
213241 attcttaggg tagcagggtg ggggtgtata gggtcttttt gaagcagttt tggataggtt

Following are NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO and REPS2 complementary DNA sequences (cDNAs; SEQ ID NO: 8, 9, 10, 11, 12, 13, 14, 15, 16 and 17, respectively). Following is a NRP1 cDNA sequence (SEQ ID NO: 8).

>gi|4505456|ref|NM_003873.1− Homo sapiens neuropilin 1 (NRP1), mRNA
ATGGAGAGGGGGCTGCCGCTCCTCTGCGCCGTGCTCGCCCTCGTCCTCGCCGCGGCCGGCGCTTTTCGCAACCATGAATGTGGCGA
TACTATAAAAATTGAAAGCCCCGGGTACCTTACATCTCCTGGTTATCCTCATTCTTATCACCCAAGTGAAAAATGCGAATGGCTGA
TTCAGGCTCCGGACCCATACCAGAGAATTATGATCAACTTCAACCCTCACTTCGATTTGGAGGACACAGACTGCAAGTATGACTAC
GTGGAAGTCTTCGATGGAGAAAATGAAAATGGACATTTTAGGGGAAAGTTCTGTGGAAAGATAGCCCCTCCTCCTGTTGTGTCTTC
AGGGCCATTTCTTTTTATCAAATTTGTCTCTGACTACGAAACACATGGTGCAGGATTTTCCATACGTTATGAAATTTTCAAGAGAG
GTCCTGAATGTTCCCAGAACTACACAACACCTAGTGGAGTGATAAAGTCCCCCGGATTCCCTGAAAAATATCCCAACAGCCTTGAA
TGCACTTATATTGTCTTTGCGCCAAAGATGTCAGAGATTATCCTGGAATTTGAAAGCTTTGACCTGGAGCCTGACTCAAATCCTCC
AGGGGGGATGTTCTGTCGCTACGACCGGCTAGAAATCTGGGATGGATTCCCTGATGTTGGCCCTCACATTGGGCGTTACTGTGGAC
AGAAAACACCAGGTCGAATCCGATCCTCATCGGGCATTCTCTCCATGGTTTTTTACACCGACAGCGCGATAGCAAAAGAAGGTTTC
TCAGCAAACTACAGTGTCTTGCAGAGCAGTGTCTCAGAAGATTTCAAATGTATGGAAGCTCTGGGCATGGAATCAGGAGAAATTCA
TTCTGACCAGATCACAGCTTCTTCCCAGTATAGCACCAACTGGTCTGCAGAGCGCTCCCGCCTGAACTACCCTGAGAATGGGTGGA
CTCCCGGAGAGGATTCCTACCGAGAGTGGATACAGGTAGACTTGGGCCTTCTGCGCTTTGTCACGGCTGTCGGGACACAGGGCGCC
ATTTCAAAAGAAACCAAGAAGAAATATTATGTCAAGACTTACAAGATCGACGTTAGCTCCAACGGGGAAGACTGGATCACCATAAA
AGAAGGAAACAAACCTGTTCTCTTTCAGGGAAACACCAACCCCACAGATGTTGTGGTTGCAGTATTCCCCAAACCACTGATAACTC
GATTTGTCCGAATCAAGCCTGCAACTTGGGAAACTGGCATATCTATGAGATTTGAAGTATACGGTTGCAAGATAACAGATTATCCT
TGCTCTGGAATGTTGGGTATGGTGTCTGGACTTATTTCTGACTCCCAGATCACATCATCCAACCAAGGAGACAGAAACTGGATGCC
TGAAAACATCCGCCTGGTAACCAGTCGCTCTGGCTGGGCACTTCCACCCGCACCTCATTCCTACATCAATGAGTGGCTCCAAATAG
ACCTGGGGGAGGAGAAGATCGTGAGGGGCATCATcATTCAGGGTGGGAAGCACCGAGAGAACAAGGTGTTCATGAGGAAGTTCAAG
ATCGGGTACAGCAACAACGGCTCGGACTGGAAGATGATCATGGATGACAGCAAACGCAAGGCGAAGTCTTTTGAGGGCAACAACAA
CTATGATACACCTGAGCTGCGGACTTTTCCAGCTCTCTCCACGCGATTCATCAGGATCTACCCCGAGAGAGCCACTCATGGCGGAC
TGGGGCTCAGAATGGAGCTGCTGGGCTGTGAAGTGGAAGCCCCTACAGCTGGACCGACCACTCCCAACGGGAACTTGGTGGATGAA
TGTGATGACGACCAGGCCAACTGCCACAGTGGAACAGGTGATGACTTCCAGCTCACAGGTGGCACCACTGTGCTGGCCACAGAAAA
GCCCACGGTCATAGACAGCACCATACAATCAGAGTTTCCAACATATGGTTTTAACTGTGAATTTGGCTGGGGCTCTCACAAGACCT
TCTGCCACTGGGAACATGACAATCACGTGCAGCTCAAGTGGAGTGTGTTGACCAGCAAGACGGGACCCATTCAGGATCACACAGGA
GATGGCAACTTCATCTATTCCCAAGCTGACGAAAATCAGAAGGGCAAAGTGGCTCGCCTGGTGAGCCCTGTGGTTTATTCCCAGAA
CTCTGCCCACTGCATGACCTTCTGGTATCACATGTCTGGGTCCCACGTCGGCACACTCAGGGTCAAACTGCGCTACCAGAAGCCAG
AGGAGTACGATCAGCTGGTCTGGATGGCCATTGGACACCAAGGTGACCACTGGAAGGAAGGGCGTGTCTTGCTCCACAAGTCTCTG
AAACTTTATCAGGTGATTTTCGAGGGCGAAATCGGAAAAGGAAACCTTGGTGGGATTGCTGTGGATGACATTAGTATTAATAACCA
CATTTCACAAGAAGATTGTGCAAAACCAGCAGACCTGGATAAAAAGAACCCAGAAATTAAAATTGATGAAACAGGGAGCACGCCAG
GATACGAAGGTGAAGGAGAAGGTGACAAGAACATCTCCAGGAAGCCAGGCAATGTGTTGAAGACCTTAGAACCCATCCTCATCACC
ATCATAGCCATGAGCGCCCTGGGGGTCCTCCTGGGGGCTGTCTGTGGGGTCGTGCTGTACTGTGCCTGTTGGCATAATGGGATGTC
AGAAAGAAACTTGTCTGCCCTGGAGAACTATAACTTTGAACTTGTGGATGGTGTGAAGTTGAAAAAAGACAAACTGAATACACAGA
GTACTTATTCGGAGGCATGA

Following is a NID2 cDNA sequence (SEQ ID NO: 9).

>gi|33469988|ref|NM_007361.2| Homo sapiens nidogen 2 (osteonidogen) (NID2), mRNA
GCCTTAGAAAAGTTAACGAGAACCAGATGTGGTGGCCACTGCCGAACTTTCTCAGAGCCGGTGATTGGTCCCCAGCCGAGGGCCTC
AGCCAATTAGCTTGCTGGGTGGGCCTGGAGTCCCGCCCCGCCCAGGCGCCCGCGGAGATCCAGGTTCGAGGCTGGCGGGGCGCGGA
GAGTGGGCTGGAGGCCGGGGCGGGACGCGTTGTGCAGCGGGTAAGCGCACGGCCGAGCGAGCATGGAGGGGGACCGGGTGGCCGGG
CGGCCGGTGCTGTCGTCGTTACCAGTGCTACTGCTGCTGCAGTTGCTAATGTTGCGGGCCGCGGCGCTGCACCCAGACGAGCTCTT
CCCACACGGGGAGTCGTGGGGGGACCAGCTCCTCCAGGAAGGCGACGACGAAAGCTCAGCCGTGGTGAAGCTGGCGAATCCCCTGC
ACTTCTACGAAGCCCGATTCAGCAACCTCTACGTGGGCACCAACGGCATCATCTCCACTCAGGACTTCCCCAGGGAAACGCAGTAT
GTGGACTATGATTTCCCCACCGACTTCCCGGCCATCGCCCCTTTTCTGGCGGACATCGACACGAGCCACGGCAGAGGCCGAGTCCT
GTACCGAGAGGACACCTCCCCCGCAGTGCTGGGCCTGGCCGCCCGCTATCTGCGCGCTGGCTTCCCGCGCTCTGCGCGCTTTACCC
CCACCCACGCCTTCCTGGCCACCTGGGAGCAGGTAGGCCCTTACGAGGAGGTCAAGCGCGGGGCGCTGCCCTCGGGAGAGCTGAAC
ACTTTCCAGGCAGTTTTGGCATCTGATGGGTCTGATAGCTACGCCCTCTTTCTTTATCCTGCCAACGGCCTGCAGTTCCTTGGAAC
CCGCCCCAAAGAGTCTTACAATGTCCAGCTTCAGCTTCCAGCTCGGGTGGGCTTCTGCCGAGGGGAGGCTGATGATCTGAAGTCAG
AACGACCATATTTCAGCTTGACTAGCACTGAACAGTCTCTGAAAAATCTCTATCAACTAAGCAACCTGGGGATCCCTGGAGTCTGG
GCTTTCCATATCGGCAGCACTTCCCCGTTGGACAATGTCAGGCCAGCTGCAGTTGGAGACCTTTCCGCTGCCCACTCTTCTGTTCC
CCTGGGACGTTCCTTCAGCCATGCTACAGCCCTGGAAAGTGACTATAATGAGGACAATTTGGATTACTACGATGTGAATGAGGAGG
AAGCTGAATACCTTCCGGGTGAACCAGAGGAGGCATTGAATCGCCACAGCAGCATTGATGTTTCCTTCCAATCCAAAGTGGATACA
AAGCCTTTAGAGGAATCTTCCACCTTGGATCCTCACACCAAAGAAGGAACATCTCTGGGAGAGGTAGGGGGCCCAGATTTAAAAGG
CCAAGTTGAGCCCTGGGATGAGAGAGAGACCAGAAGCCCAGCTCCACCAGAGGTAGACAGAGATTCACTGGCTCCTTCCTGGGAAA
CCCCACCACCGTACCCCGAAAACGGAAGCATCCAGCCCTACCCAGATGGAGGGCCAGTGCCTTCGGAAATGGATGTTCCCCCAGCT
CATCCTGAAGAAGAAATTGTTCTTCGAAGTTACCCTGCTTCAGGTCACACTACACCCTTAAGTCGAGGGACGTATGAGGTGGGACT
GGAAGACAACATAGGTTCCAACACCGAGGTCTTCACGTATAATGCTGCCAACAAGGAAACCTGTGAACACAACCACAGACAATGCT
CCCGGCATCCCTTCTGCACGGACTATGCCACTGGCTTCTGCTGCCACTGCCAATCCAAGTTTTATGGAAATCGGAAGCACTGTCTG
CCTGAGGGGGCACCTCACCGAGTGAATGGGAAAGTGAGTGGCCACCTCCACGTGGGCCATACACCCGTGCACTTCACTGATGTGGA
CCTGCATGCGTATATCGTGGGCAATGATGGCAGAGCCTACACGGCCATCAGCCACATCCCACAGCCAGCAGCCGAGGCCCTCCTCC
CCCTCACACCAATTGGAGGCCTGTTTGGCTGGCTCTTTGCTTTAGAAAAACCTGGCTCTGAGAACGGCTTCAGCCTCGCAGGTGCT
GCCTTTACCCATGACATGGAAGTTACATTCTACCCGGGAGAGGAGACGGTTCGTATCACTCAAACTGCTGAGGGACTTGACCCAGA
GAACTACCTGAGCATTAAGACCAACATTCAAGGCCAGGTGCCTTACGTCCCAGCAAATTTCACAGCCCACATCTCTCCCTACAAGG
AGCTGTACCACTACTCCGACTCCACTGTGACCTCTACAAGTTCCAGAGACTACTCTCTGACTTTTGGTGCAATCAACCAAACATGG
TCCTACCGCATCCACCAGAACATCACTTACCAGCTGTGCAGGCACGCCCCCAGACACCCGTCCTTCCCCACCACCCAGCAGCTGAA
CGTGGACCGGGTCTTTGCCTTGTATAATGACGAAGAAAGAGTGCTTAGATTTGCTGTGACCAATCAAATTGGCCCGGTCAAAGAAG
ATTCAGACCCCACTCCGGGGAATCCTTGCTATGATGGGAGCCACATGTGTGACACAACAGCACGGTGCCATCCAGGGACAGGTGTA
GATTACACCTGTGAGTGCGCATCTGGGTACCAGGGAGATGGACGGAACTGTGTGGATGAAAATGAATGTGCAACTGGCTTTCATCG
CTGTGGCCCCAACTCTGTATGTATCAACTTGCCTGGAAGCTACAGGTGTGAGTGCCGGAGTGGTTATGAGTTTGCAGATGACCGGC
ATACTTGCATCTTGATCACCCCACCTGCCAACCCCTGTGAGGATGGCAGTCATACCTGTGCTCCTGCTGGGCAGGCCCGGTGTGTT
CACCATGGAGGCAGCACGTTCAGCTGTGCCTGCCTGCCTGGTTATGCCGGCGATGGGCACCAGTGCACTGATGTAGATGAATGCTC
AGAAAACAGATGTCACCCTGCAGCTACCTGCTACAATACTCCTGGTTCCTTCTCCTGCCGTTGTCAACCCGGATATTATGGGGATG
GATTTCAGTGCATACCTGACTCCACCTCAAGCCTGACACCCTGTGAACAACAGCAGCGCCATGCCCAGGCCCAGTATGCCTACCCT
GGGGCCCGGTTCCACATCCCCCAATGCGACGAGCAGGGCAACTTCCTGCCCCTACAGTGTCATGGCAGCACTGGTTTCTGCTGGTG
CGTGGACCCTGATGGTCATGAAGTTCCTGGTACCCAGACTCCACCTGGCTCCACCCCGCCTCACTGTGGACCATCACCAGAGCCCA
CCCAGAGGCCCCCGACCATCTGTGAGCGCTGGAGGGAAAACCTGCTGGAGCACTACGGTGGCACCCCCCGGGATGACCAGTACGTG
CCCCAGTGCGATGACCTGGGCCACTTCATCCCCCTGCAGTGCCACGGAAAGAGCGACTTCTGCTGGTGTGTGGACAAAGATGGCAG
AGAGGTGCAGGGCACCCGCTCCCAGCCAGGCACCACCCCTGCGTGTATACCCACCGTCGCTCCACCCATGGTCCGGCCCACGCCCC
GGCCAGATGTGACCCCTCCATCTGTGGGCACCTTCCTGCTCTATACTCAGGGCCAGCAGATTGGCTACTTACCCCTCAATGGCACC
AGGCTTCAGAAGGATGCAGCTAAGACCCTGCTGTCTCTGCATGGCTCCATAATCGTGGGAATTGATTACGACTGCCGGGAGAGGAT
GGTGTACTGGACAGATGTTGCTGGACGGACAATCAGCCGTGCTGGTCTGGAACTGGGAGCAGAGCCTGAGACGATCGTGAATTCAG
GTCTGATAAGCCCTGAAGGACTTGCCATAGACCACATCCGCAGAACAATGTACTGGACGGACAGTGTCCTGGATAAGATAGAGAGC
GCCCTGCTGGATGGCTCTGAGCGCAAGGTCCTCTTCTACACAGATCTGGTGAATCCCCGTGCCATCGCTGTGGATCCAATCCGAGG
CAACTTGTACTGGACAGACTGGAATAGAGAAGCTCCTAAAATTGAAACGTCATCTTTAGATGGAGAAAACAGAAGAATTCTGATCA
ATACAGACATTGGATTGCCCAATGGCTTAACCTTTGACCCTTTCTCTAAACTGCTCTGCTGGGCAGATGCAGGAACCAAAAAACTG
GAGTGTACACTACCTGATGGAACTGGACGGCGTGTCATTCAAAACAACCTCAAGTACCCCTTCAGCATCGTAAGCTATGCAGATCA
CTTCTACCACACAGACTGGAGGAGGGATGGTGTTGTATCAGTAAATAAACATAGTGGCCAGTTTACTGATGAGTATCTCCCAGAAC
AACGATCTCACCTCTACGGGATAACTGCAGTCTACCCCTACTGCCCAACAGGAAGAAAGTAAGTACAGTAATGTAAAGGAAGACTT
GGAGTTTACAATCAGAACCTGGACCCTAAAGAACAGTGACTGCAAAGGCAAAGAAAGTAAAAAAGGAATTGGCCATTAGACGTTCC
TGAGCATCCAAGATGAACATTTTGTAGTGCAAAAAGACTTTTGTGAAAAGCTGATACCTCAATCTTTACTACTGTATTTTTAAAAA
TGAAGGTTGTTATTGCAAGTTTAAAAAGGTAACAGAATTTTAACTGTTGCTTATTAAAGCAACTTCTTGTAAACATTTATCATTAA
TATTTAAAAGATCAAATTCATTCAACTAAGAATTAGAGTTTAAGACTCTAAACCTGATTTTTGCCATGGATTCCTTCTGGCCAAGA
AATTAAAGCACATGTGATCAATATAACAATATAATCCTAAACCTTGACAGTTGGAGAAGCCAATGCAGAACTGATGGGAAAGGACC
AATTATTTATAGTTTCCCAACAAAAGTTCTAAGATTTTTTACCTCTGCATCAGTGCATTTCTATTTATATCAAAAGGTGCTAAAAT
GATTCAATTTGCATTTTCTGATCCTGTAGTGCCTCTATAGAAGTACCCACAGAAAGTAAAGTATCACATTTATAAATACCAAAGAT
GTAACAATTTTAAAATTTTCTAGATTACTCCAATAAAGTGTTTTAAGTTTTCCTATGAAAAAAAAAAAAAAAAAAAA

Following is a ENDO180 cDNA sequence (SEQ ID NO: 10).

>gi|5174484|ref|NM_006039.1| Homo sapiens mannose receptor, C type 2 (MRC2), mRNA
CGGAGGAGGACGCGAGCCCCTTGCGGGCGGTCATCACAGCCCAGCCTCGGGGCTGCCACAGCGCGTTGCGCCTGTGCGCCCTCGGT
CCCCGCGTCCACTGAGCGCCGCGCTCGGGGATGGGGCCCGGCCGGCCGGCCCCCGCGCCCTGGCCTCGTCACCTGCTGCGCTGCGT
CCTGCTCCTCGGGTGCCTGCACCTCGGCCGTCCCGGCGCCCCTGGGGACGCCGCCCTCCCGGAACCCAACGTCTTCCTCATCTTCA
GCCATGGACTGCAGGGCTGCCTGGAGGCCCAGGGCGGGCAGGTCAGAGTCACCCCGGCTTGCAATACCAGCCTCCCTGCCCAGCGC
TGGAAGTGGGTCTCCCGAAACCGGCTATTCAACCTGGGTACCATGCAGTGCCTGGGCACAGCCTGGCCAGGCACCAACACCACGGC
CTCCCTGGGCATCTATGAGTGTGACCGGGAAGCACTGAATCTTCGCTGGCATTGTCGTACACTGGGTGACCAGCTGTCCTTGCTCC
TGGGGGCCCGCACCAGCAACATATCCAACCCTGGCACCCTTGAGCGTGGTGACCAGACCCGCAGTGGCCAGTGGCGCATCTACGGC
AGCGAGGAGGACCTATGTGCTCTGCCCTACCACGAGGTCTACACCATCCAGGGAAACTCCCACGGAAAGCCGTCCACCATCCCCTT
CAAATATGACAACCAGTGGTTCCACGGCTGCACCAGCACGGGCCGCGAGGATGGTCACCTGTGGTGTCCCACCACCCAGGACTACG
GCAAAGACGAGCGCTGGGGCTTCTGCCCCATCAAGAGTAACGACTGCGAGACCTTCTGGGACAAGGACCAGCTGACTGACAGCTGC
TACCAGTTTAACTTCCAGTCCACGCTGTCGTGGAGGGAGCCCTGGGCCAGCTGCGAGCAGCAGGGTGCCGATCTCCTGAGCATCAC
GGAGATCCACGAGCACACCTACATCAACGGCCTCCTCACTCGGTACAGCTCCACCCTGTGGATCGGCTTGAATCACTTGGACACGA
CCGGAGGCTGGCAGTGGTCGGACAACTCGCCCCTCAAGTACCTCAACTGGGAGAGTGACCAGCCGGACAACCCCAGTGAGGAGAAC
TGTGGAGTGATCCGCACTGAGTCCTCGGGCGGCTGGCAGAACCGTGACTGCAGCATCGCGCTGCCCTATGTGTGCAAGAAGAAGCC
CAACGCCACGGCCGAGCCCACCCCTCCAGACAGGTGGGCCAATGTGAAGGTGGAGTGCGAGCCGAGCTCCCAGCCCTTCCAGGGCC
ACTGCTACCGCCTGCAGGCCGACAAGCGCAGCTGGCAGGAGTCCAAGAAGGCATGTCTACGGGGCGGTGGCGACCTGGTCAGCATC
CACAGCATGGCGGAGCTGGAATTCATCACCAAGCAGATCAAGCAAGAGGTCGAGGAGCTGTGGATCGGCCTCAACGATTTGAAACT
GCAGATGAATTTTGAGTGGTCTGACGGGAGCCTTGTGACCTTCACCCACTGGCACCCCTTTGAGCCCAACAACTTCCGGGACAGTC
TGGAGGACTGTGTCACCATCTGGGGCCCGGAAGGCCGCTGGAACGACAGTCCCTGTAACCAGTCCTTGCCATCCATCTGCAAGAAG
GCAGGCCAGCTGAGCCAGGGGGCCGCCGAGGAGGACCATGGCTGCCGGAAGGGTTGGACGTGGCACAGCCCATCCTGCTACTGGCT
GGGAGAAGACCAAGTGACCTACAGTGAGGCCCGGCGCCTGTGCACTGACCATGGCTCTCAGCTGGTCACCATCACCAACAGGTTCG
AGCAGGCCTTCGTCAGCAGCCTCATCTACAACTGGGAGGGCGAGTACTTCTGGACGGCCCTGCAGGACCTCAACAGCACCGGCTCC
TTCTTCTGGCTCAGTGGGGATGAAGTCATGTACACCCACTGGAACCGGGACCAGCCCGGGTACAGCCGTGGGGGCTGCGTGGCGCT
GGCCACTGGCAGCGCCATGGGGCTGTGGGAGGTGAAGAACTGTACCTCGTTCCGGGCCCGCTACATCTGCCGGCAGAGCCTGGGCA
CTCCAGTGACGCCGGAGCTGCCCGGGCCAGATCCCACGCCCAGCCTCACTGGCTCCTGTCCCCAGGGCTGGGCCTCGGACACCAAA
CTCCGGTATTGCTATAAGGTGTTCAGCTCAGAGCGGCTGCAGGACAAGAAGAGCTGGGTCCAGGCCCAGGGGGCCTGCCAGGAGCT
GGGGGCCCAGCTGCTGAGCCTCCCCAGCTACGAGGAGGAGCACTTTGTGGCCAACATGCTCAACAAGATCTTCGGTGAATCAGAAC
CCGAGATCCACGAGCAGCACTGGTTCTGGATCGGCCTGAACCGTCGGGATCCCAGAGGGGGTCAGAGTTGGCGCTGGAGCGACGGC
GTAGGCTTCTCTTACCACAATTTCGACCGGAGCCGGCACCACGACGACGACATCCGAGGCTGTGCGGTGCTGGACCTGGCCTCCCT
GCACTGGGTGGCCATGCAGTGCGACACACAGCTGGACTGGATCTGCAAGATCCCCAGAGGTACGGACGTGCGGGAGCCCGACGACA
GCCCTCAAGGCCGACGGGAATGGCTGCGCTTCCAGGAGGCCGAGTACAAGTTCTTTGAGCACCACTCCACGTGGGCGCAGGCGCAG
CGCATCTGCACGTGGTTCCAGGCCGAGCTGACCTCCGTGCACAGCCAGGCAGAGCTAGACTTCCTGAGCCACAACTTGCAGAAGTT
CTCCCGGGCCCAGGAGCAGCACTGGTGGATCGGCCTGCACACCTCTGAGAGCGATGGGCGCTTCAGATGGACAGATGGTTCCATTA
TAAACTTCATCTCCTGGGCACCAGGCAAACCTCGGCCTGTCGGCAAGGACAAGAAGTGCGTGTACATGACAGCCAGCCGAGAGGAC
TGGGGGGACCAGAGGTGCCTGACAGCCTTGCCCTACATCTGCAAGCGCAGCAACGTCACCAAAGAAACGCAGCCCCCAGACCTGCC
AACTACAGCCCTGGGGGGCTGCCCCTCTGACTGGATCCAGTTCCTCAACAAGTGTTTTCAGGTCCAGGGCCAGGAACCCCAGAGCC
GGGTGAAGTGGTCAGAGGCACAGTTCTCCTGTGAACAGCAAGAGGCCCAGCTGGTCACCATCACAAACCCCTTAGAGCAAGCATTC
ATCACAGCCAGCCTGCCCAATGTGACCTTTGACCTTTGGATTGGCCTCCATGCCTCGCAGAGGGACTTCCAGTGGGTGGAGCAGGA
GCCTTTGATGTATGCCAACTGGGCACCTGGGGAGCCCTCTGGCCCTAGCCCTGCTCCCAGTGGCAACAAACCGACCAGCTGTGCGG
TGGTCCTGCACAGCCCCTCAGCCCACTTCACTGGCCGCTGGGACGATCGGAGCTGCACGGAGGAGACCCATGGCTTCATCTGCCAG
AAGGGCACGGACCCCTCCCTGAGCCCGTCCCCAGCAGCGCTGCCCCCCGCCCCGGGCACTGAGCTCTCCTACCTCAACGGCACCTT
CCGGCTGCTTCAGAAGCCGCTGCGCTGGCACGATGCCCTCCTGCTGTGTGAGAGCCACAATGCCAGCCTGGCCTACGTGCCCGACC
CCTACACCCAGGCCTTCCTCACGCAGGCTGCCCGAGGGCTGCGCACGCCGCTCTGGATTGGGCTGGCTGGCGAGGAGGGCTCTCGG
CGGTACTCCTGGGTCTCAGAGGAGCCGCTGAACTACGTGGGCTGGCAGGACGGGGAGCCGCAGCAGCCGGGGGGCTGTACCTACGT
AGATGTGGACGGGGCCTGGCGCACCACCAGCTGTGACACCAAGCTGCAGGGGGCTGTGTGTGGGGTTAGCAGTGGGCCCCCTCCTC
CCCGAAGAATAAGCTACCATGGCAGCTGTCCCCAGGGACTGGCAGACTCCGCGTGGATTCCCTTCCGGGAGCACTGCTATTCTTTC
CACATGGAGCTGCTGCTGGGCCACAAGGAGGCGCGACAGCGCTGCCAGAGAGCGGGTGGGGCCGTCCTGTCTATCCTGGATGAGAT
GGAGAATGTGTTTGTCTGGGAGCACCTGCAGAGCTATGAGGGCCAGAGTCGGGGCGCCTGGCTGGGCATGAACTTCAACCCCAAAG
GAGGCACTCTGGTCTGGCAGGACAACACAGCTGTGAACTACTCCAACTGGGGGCCCCCGGGCTTGGGCCCCAGCATGCTGAGCCAC
AACAGCTGCTACTGGATTCAGAGCAACAGCGGGCTATGGCGCCCCGGCGCTTGCACCAACATCACCATGGGTGTCGTCTGCAAGCT
TCCTCGTGCTGAGCAGAGCAGCTTCTCCCCATCAGCGCTTCCAGAGAACCCAGCGGCCCTGGTGGTGGTGCTGATGGCGGTGCTGC
TGCTCCTGGCCTTGCTGACCGCAGCCCTCATCCTTTACCGGAGGCGCCAGAGCATCGAGCGCGGGGCCTTTGAGGGTGCCCGCTAC
AGCCGCAGCAGCTCCAGCCCCACCGAGGCCACTGAGAAGAACATCCTGGTGTCAGACATGGAAATGAATGAGCAACAAGAATAGAG
CCAGGCGCGTGGGCAGGGCCAGGGCGGGAGGAGCTGGGGAGCTGGGGCCCTGGGTCAGTCTGGCCCCCCACCAGCTGCCTGTCCAG
TTGGCCTATGGAAGGGTGCCCTTGGGAGTCGCTGTTGGGAGCCGGAGCTGGGCAGAGCCTGGGCTGGTGGGGTGCCACCCTCCCAC
AAGGGCTGGGCTGAGACCCAGCTGAGTGCAGCGTGGCGTTTCCCTTTCTGGGGGGGCCTGAGGTCTTGTCACCTGGTCCTGTGCCC
CCACAGGAACCAGAGGTAGGATGGGAGGGGGAACGAGAGCCTCTTTCTCCCCAGAGCCCCCGGCCCAGGCCTGTTGATCCGCGCCC
CAGGACCCCCTTCTTTGCAGAGCCCGAGGAGCCTCCCCTGTCCCCTCGGGCAGATCTGTTGTGTCTCTCTTCCCACCTGGCAGCCT
CAGCTCTGTGCCCCTCACCCTGCTCCCTCTCGCCCCTTCTCTCCCACCCCTTCCTTCTGAGCCGGGCCCTGGGGATTGGGGAGCCC
TCTTGTTCCTGATGAGGGTCAGCTGAGGGGGCTGAGCATCCATCACTCCTGTGCCTGCTGGGGTGGCTGTGGGGCGTGGCAGGAGG
GGCCTAGGTGGGTTGGGCCTGAGAACCAGGGCACGGGTGTGGTGTCTGCTGGGCTGGAGATAAGACTGGGGAGAGACACCCCAACC
TCCCAGGGTGGGAGCTGGGCCGGGCTGGGATGTCATCTCCTGCCGGGCGGGGGAGGGCTCTGCCCCTGGAAGAGTCCCCTGTGGGG
ACCAAAATAAGTTCCCTAACATCTCCAGCTCCTGGCTCTGGTTTGGAGCAAGGGGAAGGGTTGCCAGAGTCCTGGGGGCCCCAGAG
GAGCAGGAGTCTGGGAGGGCCCAGAGTTCACCCTCTAGTGGATCCAGGAGGAGCAGCACCCGAGCCCTGGAGTGGCCCAGTACCCT
TCCAAGAGGCCACAGTCCCAGCCAGGACAAAGTATGCGGCCCATCCTGGTGCGACAGCGTGGGACAATGTGAACATGGACTCGAAG
ACATGGCCCTTTCTCTGTAGTTGATTTTTTAAATGTGCCATTATTGTTTTT

Following is a first CDK10 cDNA sequence (SEQ ID NO: 11).

>gi|32528262|ref|NM_003674.2| Homo sapiens cyclin-dependent kinase (CDC2-like) 10
(CDK10), transcript variant 1, mRNA
GTCTGCGCCTGCGCGCAAGAGAGGCGGGGCCAGCGCTCGGCATGGCGGAGCCAGATCTGGAGTGCGAGCAGATCCGTCTGAAGTGT
ATTCGTAAGGAGGGCTTCTTCACGGTGCCTCCGGAACACAGGGTGACCCACCGCCCCCAGCCTGGCCTGGCATTTCTTTGAGTTCA
GGAAGTGTGACAAGGATTTGGACACCCAGAAATAAGCGTGTCGAGAAGAGCACAAGCAGAGGATCTGGGACCATGCCGGAGTGTGA
AGGAGTTTGAGAAGCTGAACCGCATTGGAGAGGGTACCTACGGCATTGTGTATCGCGCCCGGGACACCCAGACAGATGAGATTGTC
GCACTGAAGAAGGTGCGGATGGACAAGGAGAAGGATGGCATCCCCATCAGCAGCTTGCGGGAGATCACGCTGCTGCTCCGCCTGCG
TCATCCGAACATCGTGGAGCTGAAGGAGGTGGTTGTGGGGAACCACCTGGAGAGCATCTTCCTGGTGATGGGTTACTGTGAGCAGG
ACCTGGCCAGCCTCCTCGAGAATATGCCAACACCCTTCTCGGAGGCTCAGGTCAAGTGCATCGTGCTGCAGGTGCTCCGGGGCCTC
CAGTATCTGCACAGGAACTTCATTATCCACAGGGACCTGAAGGTTTCCAACTTGCTCATGACCGACAAGGGTTGTGTGAAGACAGC
GGATTTCGGCCTGGCCCCGGCCTATGGTGTCCCAGTAAAGCCAATGACCCCCAAGGTGGTCACTCTCTCGTACCGAGCCCCTGAAC
TGCTGTTGGGAACCACCACGCAGACCACCAGCATCGACATGTGGGCTGTGGGCTGCATACTCGCCGAGCTGCTGGCGCACAGGCCT
CTTCTCCCCGGCACTTCCGAGATCCACCAGATCGACTTGATCGTGCAGCTGCTGGGCACGCCCAGTGAGAACATCTGGCCGGGCTT
TTCCAAGCTGCCACTGGTCGGCCAGTACAGCCTCCGGAAGCAGCCCTACAACAACCTGAAGCACAAGTTCCCATGGCTGTCGGAGG
CCGGGCTGCGCCTGCTGCACTTCCTGTTCATGTACGACCCTAAGAAAAGGGCGACGGCCGGGGACTGCCTGCAGAGCTCCTATTTC
AAGGAGAAGCCCCTACCCTGTGAGCCGGAGCTCATGCCGACCTTTCCCCACCACCGCAACAAGCGGGCCGCCCCAGCCACCTCCGA
GGGCCAGAGCAAGCGCTGTAAACCCTGACGGTGGGCCTGGCACACGCCTGTATTCCCACACCAGGTCTTCCGATCAGTGGTGTCTG
TGAAGGGTGCCGCGAGCCAGGCTGACCAGGCGCCCGGGATCCAGCTCATCCCCTTGGCTGGGAACATCCTCCACTGACTTCCTCCC
ACTGTCTGCCCTGAACCCACTGCTGCCCCCAGAAAAAGGCCGGGTGACACCGGGGGGCTCCCAGCCCCTGCACCCTGGAAGGGCAG
GTCTGGCGGCTCCATCCGTGGCTGCAGGGGTCTCATGTGGTCCTCCTCGCTATGTTGGAAATGTGCAACCACTGCTTCTTGGGAGG
AGTGGTGGGTGCAGTCCCCCCGCTGTCTTTGAGTTGTGGTGGACGCTGGCCTGGGATGAGAGGGCCCAGAAGACCTTCGTATCCCC
TCTCAGTCGCCCGGGGCTGTCCCGTGCATGGGTTGGCTGTGGGGACCCCAGGTGGGCCTGGCAGGACTCCAGATGAGGACAAGAGG
GACAAGGTATGGGGTGGGAGCCACAATTGAGGATACCCCGAGACTACCAGGAGAGCCCTGGGCTGGAGGCTGAGCTGCATCCCTGC
TCCCCACATGGAGGACCCAACAGGAGGCCGTGGCTCTGATGCTGAGCGAAGCTATAGGCTCTTGTTGGATAAAAGCTTTTTTAACA

Following is a seco-nd CDK10 cDNA sequence (SEQ ID NO: 12).

>gi|32528264|ref|NM_052987.2| Homo sapiens cyclin-dependent kinase (CDC2-like) 10
(CDK10), transcript variant 2, mRNA
GTCTGCGCCTGCGCGCAAGAGAGGCGGGGCCAGCGCTCGGCATGGCGGAGCCAGATCTGGAGTGCGAGCAGATCCGTCTGAAGTGT
ATTCCTGGGACGATGCCGGAGTGTGAAGGAGTTTGAGAAGCTGAACCGCATTGGAGAGGGTACCTACGGCATTGTGTATCGGGCCC
GGGACACCCAGACAGATGAGATTGTCGCACTGAAGAAGGTGCGGATGGACAAGGAGAAGGATGGCATCCCCATCAGCAGCTTGCGG
GAGATCACGCTGCTGCTCCGCCTGCGTCATCCGAACATCGTGGAGCTGAAGGAGGTGGTTGTGGGGAACCACCTGGAGAGCATCTT
CCTGGTGATGGGTTACTGTGAGCAGGACCTGGCCAGCCTCCTGGAGAATATGCCAACACCCTTCTCGGAGGCTCAGGTCAAGTGCA
TCGTGCTGCAGGTGCTCCGGGGCCTCCAGTATCTGCACAGGAACTTCATTATCCACAGGGACCTGAAGGTTTCCAACTTGCTCATG
ACCGACAAGGGTTGTGTGAAGACAGCGGATTTCGGCCTGGCCCGGGCCTATGGTGTCCCAGTAAAGCCAATGACCCCCAAGGTGGT
CACTCTCTGGTACCGAGCCCCTGAACTGCTGTTGGGAACCACCACGCAGACCACCAGCATCGACATGTGGGCTGTGGGCTGCATAC
TGGCCGAGCTGCTGGCGCACAGGCCTCTTCTCCCCGGCACTTCCGAGATCCACCAGATCGACTTGATCGTGCAGCTGCTGGGCACG
CCCAGTGAGAACATCTGGCCGGGCTTTTCCAAGCTGCCACTGGTCGGCCAGTACAGCCTCCGGAAGCAGCCCTACAACAACCTGAA
GCACAAGTTCCCATGGCTGTCGGAGGCCGGGCTGCGCCTGCTGCACTTCCTGTTCATGTACGACCCTAAGAAAAGGGCGACGGCCG
GGGACTGCCTGGAGAGCTCCTATTTCAAGGAGAAGCCCCTACGTCTTCCGATCAGTGGTGTCTGTGAAGGGTGCCGCGAGCCAGGC
TGACCAGGCGCCCGGGATCCAGCTCATCCCCTTGGCTGGGAACATCCTCCACTGACTTCCTCCCACTGTCTGCCCTGAACCCACTG
CTGCCCCCAGAAAAAGGCCGGGTGACACCGGGGGGCTCCCAGCCCGTGCACCCTGGAAGGGCAGGTCTGGCGGCTCCATCCGTGGC
TGCAGGGGTCTCATGTGGTCCTCCTCGCTATGTTGGAAATGTGCAACCACTGCTTCTTGGGAGGAGTGGTGGGTGCAGTCCCCCCG
CTGTCTTTGAGTTGTGGTGGACGCTGGCCTGGGATGAGAGGGCCCAGAAGACCTTCGTATCCCCTCTCAGTCGCCCGGGGCTGTCC
CGTGCATGGGTTGGCTGTGGGGACCCCAGGTGGGCCTGGCAGGACTCCAGATGAGGACAAGAGGGACAAGGTATGGGGTGGGAGCC
ACAATTGAGGATACCCCGAGACTACCAGGAGAGCCCTGGGCTGGAGGCTGAGCTGCATCCCTGCTCCCCACATGGAGGACCCAACA
GGAGGCCGTGGCTCTGATGCTGAGCGAAGCTATAGGCTCTTGTTGGATAAAAGCTTTTTTAACAGAAAAAAAAAAAAAAAAAAAA

Following is a third CDK10 cDNA sequence (SEQ ID NO: 13).

>gi|32528265|ref|NM_052988.2| Homo sapiens cyclin-dependent kinase (CDC2-like) 10
(CDK10), transcript variant 3, mRNA
GTCTGCGCCTGCGCGCAAGAGAGGCGGGGCCAGCGCTCGGCATGGCGGAGCCAGATCTGGAGTGCGAGCAGATCCGTCTGAAGTGT
ATTCGTAAGGAGGGCTTCTTCACGGTGCCTCCGGAACACAGGATCGGGCCCGGGACACCCAGACAGATGAGATTGTCGCACTGAAG
AAGGTGCGGATGGACAAGGAGAAGGATGGCATCCCCATCAGCAGCTTGCGGGAGATCACGCTGCTGCTCCGCCTGCGTCATCCGAA
CATCGTGGAGCTGAAGGAGGTGGTTGTGGGGAACCACCTGGAGAGCATCTTCCTGGTGATGGGTTACTGTGAGCAGGACCTGGCCA
GCCTCCTGGAGAATATGCCAACACCCTTCTCGGAGGCTCAGGTCAAGTGCATCGTGCTGCAGGTGCTCCGGGGCCTCCACTATCTG
CACAGGAACTTCATTATCCACAGGGACCTGAAGGTTTCCAACTTGCTCATGACCGACAAGGGTTGTGTGAAGACAGGTGGGTGCAA
CTTGGGCCAGGCCCTGTCCCTAGATGGCACTTGGTGACACACACTCCCCTCTCTGCTGCAGCGGATTTCGGCCTGGCCCGGGCCTA
TGGTGTCCCAGTAAAGCCAATGACCCCCAAGGTGGTCACTCTCTGGTACCGAGCCCCTGAACTGCTGTTGGGAACCACCACGCAGA
CCACCAGCATCGACATGTGGGCTGTGGGCTGCATACTGGCCGAGCTGCTGGCGCACAGGCCTCTTCTCCCCGGCACTTCCGAGATC
CACCAGATCGACTTGATCGTGCAGCTGCTGGGCACGCCCAGTGAGAACATCTGGCCGGCCTTTTCCAAGCTGCCACTGGTCGGCCA
GTACAGCCTCCGGAAGCAGCCCTACAACAACCTGAAGCACAAGTTCCCATGGCTGTCGGAGGCCGGGCTGCGCCTGCTGCACTTCC
TGTTCATGTACGACCCTAAGAAAAGGGCGACGGCCGGGGACTGCCTGGAGAGCTCCTATTTCAAGGAGAAGCCCCTACCCTGTGAG
CCGGAGCTCATGCCGACCTTTCCCCACCACCGCAACAAGCGGGCCGCCCCAGCCACCTCCGAGGGCCAGAGCAAGCGCTGTAAACC
CTGACGGTGGGCCTGGCACACGCCTGTATTCCCACACCAGGTCTTCCGATCAGTGGTGTCTGTGAAGGGTGCCGCGAGCCAGGCTG
ACCAGGCGCCCGGGATCCAGCTCATCCCCTTCGCTGGGAACATCCTCCACTGACTTCCTCCCACTGTCTGCCCTGAACCCACTGCT
GCCCCCAGAAAAAGGCCGGGTGACACCGGGGGGCTCCCAGCCCGTGCACCCTGGAAGGGCAGGTCTGGCGGCTCCATCCGTGGCTG
CAGGGGTCTCATGTGGTCCTCCTCGCTATGTTGGAAATGTGCAACCACTGCTTCTTGGGAGGAGTGGTGGGTGCAGTCCCCCCGCT
GTCTTTGAGTTGTGGTGGACGCTGGCCTGGGATCAGAGGGCCCAGAAGACCTTCGTATCCCCTCTCAGTCGCCCGGGGCTGTCCCG
TGCATGGGTTGGCTGTGGGGACCCCAGGTGGGCCTGGCAGGACTCCAGATGAGGACAACAGGGACAAGGTATGGGGTGGGAGCCAC
AATTGAGGATACCCCGAGACTACCAGGAGAGCCCTGGGCTGGAGGCTGAGCTGCATCCCTGCTCCCCACATGGAGGACCCAACAGG
AGCCCGTGGCTCTGATGCTGAGCGAAGCTATAGGCTCTTGTTGGATAAAAGCTTTTTTAACAGAAAAAAAAAAAAAAAAAAAA

Following is a FPGT cDNA sequence (SEQ ID NO: 14).

>gi|4503776|ref|NM_003838.1| Homo sapiens fucose-1-phosphate guanylyltransferase
(FPGT), mRNA
GCGTGCTGTGCGGCGCGGTCTCAGGGAAGGTGGGGCTATGGCAGCTGCTAGGGACCCTCCGGAAGTATCGCTGCGAGAAGCCACCC
AGCGAAAATTGCGGAGGTTTTCCGAGCTAAGAGGCAAACTTGTAGCACGTGGAGAATTCTGGGACATAGTTGCAATAACAGCGGCT
GATGAAAAACAGGAACTTGCTTACAACCAACAGCTGTCAGAAAAGCTGAAAAGAAAGGAGTTACCCCTTGGAGTTCAATATCACGT
TTTTGTGGATCCTGCTGGACCCAAAATTGGAAATGGAGGATCAACACTTTGTGCCCTTCAATGTTTGGAAAAGCTATATGGAGATA
AATGGAATTCTTTTACCATCTTATTAATTCACTCTGGTGGCTACAGTCAACGACTTCCAAATGCAAGTGCTCTGGGAAAAATTTTC
ACTGCTTTACCTCTTGGTAACCCCATTTATCAGATGCTAGAATTAAAGCTAGCCATGTACATTGATTTCCCCTTAAATATGAATCC
TGGAATTCTGGTTACCTGTGCAGATGATATTGAACTTTATAGTATTGGAGAATTTGAGTTTATTAGGTTTGACAAACCTGGCTTTA
CTGCTTTAGCTCATCCTTCTAGTTTGACGATAGGTACCACACATGGAGTATTTGTCTTAGATCCTTTTGATGATTTAAAACATAGA
GACCTTGAATACAGGTCTTGCCATCGTTTCCTTCATAAGCCCAGCATAGAAAAGATGTATCAGTTTAATGCTGTGTGTAGACCTGG
AAATTTTTGTCAACAGGACTTTGCTGGGGGTGACATTGCCGATCTTAAATTAGACTCTGACTATGTCTACACAGATAGCCTATTTT
ATATGGATCATAAATCAGCAAAAATGTTACTTGCTTTTTATGAAAAAATAGGCACACTGAGCTGTGAAATAGATGCCTATGGTGAC
TTTCTGCAGGCTTTGGGACCTGGAGCAACTGTGGAGTACACCAGAAACACATCACATGTCATTAAAGAAGAGTCAGAGTTGGTAGA
AATGAGGCAGAGAATATTTCATCTTCTTAAAGGAACATCACTAAATGTTGTTGTTCTTAATAACTCCAAATTTTATCACATTGGAA
CAACCGAAGAATATTTGTTTTACTTTACCTCAGATAACAGTTTAAAGTCAGAGCTCGGCTTACAGTCCATAACTTTTAGTATCTTT
CCAGATATACCAGAATGCTCTGGCAAAACATCCTGTATCATTCAAAGCATACTGGATTCAAGATGTTCTGTGGCACCTGGCTCAGT
TGTGGAGTATTCCAGATTGGGGCCTGATGTTTCAGTTGGGGAAAACTGCATTATTAGTGGTTCTTACATCCTAACAAAAGCTGCCC
TCCCCGCACATTCTTTTGTATGTTCCTTAAGCTTAAAGATGAATAGATGCTTAAAGTATGCAACTATGGCATTTGGAGTGCAAGAC
AACTTGAAAAAGAGTGTGAAAACATTGTCAGATATAAAGTTACTTCAATTCTTTGGAGTCTGTTTCCTGTCATGCTTAGATGTTTG
GAATCTTAAAGTTACAGAGGAACTGTTCTCTGGTAACAAGACATGTCTGAGTTTGTGGACTGCACGCATTTTCCCAGTTTGTTCTT
CTTTGAGTGACTCAGTTATAACATCCCTAAAGATGTTAAATGCTGTTAAGAACAAGTCAGCATTCAGCCTGAATAGCTATAAGTTG
CTGTCCATTGAAGAAATGCTTATCTACAAAGATGTAGAAGATATGATAACTTACAGGGAACAAATTTTTCTAGAAATCAGTTTAAA
AAGCAGTTTGATGTAGAGATATTTTAAATATTGTACACTTTGCCTTTTTGAGTAACATTCCAGAGATAGGTATTTTTGGTAGGCTG
TTTCACTGAACTCAGTTAATGAAAACTGTATTAACATAATTGTTGTAGCATAATATTAATAGTGCAAAAGTACATATAAGTCATTT
TGATGAAAAATATTCCAAGACTAAGTTGAGAAAAGAGATACTATTTTGGATGTGTATCAGTATTTTTGTTTTTAATAATGATTGAT
TTGTGGAGCATTGTTTTTTCACATAATTAGTTTTAAAGGTAATTTTCTAAGCATACCTTTGGAATTTTTCCATCTTTTTTGAGGCT
TTTGGTCCAGTGAAGTTCTAAGTATTCACTGGCACTTCTCTCCTCAACTGTAATTCTATTTTTAATAATAAAAATGGCATACTGTA
GGGTCTTCAGAGTAGTGTAGGAATACTGTAGAAATACTTTTTCAGAAACGAATCCATAGCTGACAAATTCACTCAGTGCCCAATAT
ATTGTGATTATTTTCGTTGATAAAGAACTAGATACAAAGACCTCTGAAATTGATGATAAAATTTGTATCTCATTAATTTTATCAAA
ATGAAACTAAAAGTACATATGTATTATACACTTGAACATGTGTTTGTATATCTTTAAAATTTTCCTTTATGTCCATTCCATAGGAA
GACACACATATGCACACAAAACTCAGTTATCTGTGGGGGAAGTGGTAGTAATAATTGAGATTCATCAATAATCATATAATTTCACT
ATAGACATTACTTGCATTATCTCCTATCAGTCCTTCTCACAAAACTTCAATTACCAGATGAACTGACTTTAGTTTTCATCTTATTT
TTTGTCCACATGCTGGTGATGCTGAGAAACAATAATTGGCCCAAATGCAGACATCAAGAAGCAGGCAGGAAIATGGAAAAACTGAG
ATAATACACAGGTGATAAACAGTTTCGAGAAAATAAAAATTGGCTAGAATCTCAAGTTATGTGTTTCTATATTGGTATAAGCATAT
AAGTGAAAAGTCTTATAAGTGTAATAGAGAAAAGATTTGTCAGTGTGTTTTTTTAAATGAAATAACTAGTCTGTGCTACTTTATGT
CAATATAAAAATTGGTAAACTAGAAGTAACTTGTCCACAACCCTCAGTTATGATACTTATGTGCGTGTTTTTTTTTCCAAAGTTTT
TCCCAAGGAGAAGATACAAATATATGGTAGCTATTGTTTAAAAATGATTGATTTACTTGCAGATTTTTCAGAGGATGTTATGTCTT
TGTCATTCATTAAATGTTCAAAATTGTAGTTTTAAAAAAAAAAAAAAA

Following is a CARK cDNA sequence (SEQ ID NO: 15).

>gi|7705747|ref|NM_015978.1| Homo sapiens cardiac ankyrin repeat kinase (CARK), mRNA
AATCTTATAACTTGAAGAACTGCCCTGGAGAAAGGAAGAAACTTATAATAAATGGGAAATTATAAATCTAGACCAACCCAAACTTG
TACTGATGAATGGAACAAAAAAGTCAGTGAATCATATGTTATCACAATAGAAAGATTAGAAGATGACCTGCAGATCAAGGAAAAAG
AACTGACAGAACTAAGGAATATATTTGGCTCTCATCAAGCCTTCAGTAAAGTCAATTTAAATTACCGCACTCAAAATGGGCTGTCT
CTACTTCATTTATGTTGCATTTCTGCAGCCAAGAAATCACATATTCGAACTCTTATGTTGAAAGGGCTCCGCCCATCTCGACTGAC
AAGAAATGGATTTACAGCCTTGCATTTAGCAGTTTACAAGGATAATGCAGAATTGATCACTTCTCTGCTTCACAGTGGAGCTGATA
TACAGCAGGTTGGATACGGTGGCCTCACTCCCCTCCATATTGCTACAATAGCTGGCCACCTAGAGGCTGCTGATGTGCTGTTGCAA
CATGGAGCTAATGTCAATATTCAAGATGCAGTTTTTTTCACTCCATTGCATATTGCAGCGTACTATGGACATGAACAGGTAACTCG
CCTTCTTTTGAAATTTGGTGCTGATGTAAATGTAAGTGGTGAAGTTGGAGATAGACCCCTCCACCTAGCATCTGCAAAAGGATTCT
TGAATATTGCAAAACTCTTGATGGAAGAAGGCAGCAAAGCACATGTGAATGCTCAAGATAATGAAGACCATGTCCCACTCCATTTC
TGTTCTCGATTTGGACACCATGATATAGTTAAGTATCTGCTGCAAAGTGATTTGGAAGTTCAACCTCATGTTGTTAATATCTATGG
AGATACCCCCTTACACCTGGCATGCTACAATGGCAAATTTGAAGTTGCCAACGAAATCATCCAAATATCAGGAACAGAAAGTCTGA
CTAAGGAAAACATCTTCAGTGAAACAGCTTTTCATAGTGCTTGTACCTATGGCAAGAGCATTGACCTAGTCAAATTTCTTCTTGAT
CAGAATGTCATAAACATCAACCACCAAGGAAGGGATGGGCACACTGGATTACACTCTGCTTGCTACCACGGTCACATTCGCCTGGT
TCAGTTCTTACTGGATAATGGAGCTGATATGAATCTAGTGGCTTGTGATCCCAGCAGGTCTAGTGGTGAAAAAGATGAGCAGACAT
GTTTGATGTGGGCTTATGAAAAAGGGCATGATGCCATTGTCACACTCCTGAAGCATTATAAGAGACCACAAGATGAATTGCCCTGT
AATGAATATTCTCAGCCTGGAGGAGATGGCTCCTATGTCTCTGTTCCATCACCCTTGGGGAAGATTAAAAGCATGACAAAAGAGAA
GGCAGATATTCTCCTCCTAAGAGCTGGATTGCCTTCACATTTCCATCTTCAGCTCTCAGAAATTGAGTTCCATGAGATTATTGGCT
CAGGTTCTTTTGGGAAAGTATATAAAGGACGATGCAGAAATAAAATAGTGGCTATAAAACGTTATCGAGCCAATACCTACTGCTCC
AAGTCAGATGTGGATATGTTTTGCCGAGAGGTGTCCATTCTCTGCCAGCTCAATCATCCCTGCGTAATTCAGTTTGTGGGTGCTTG
CTTGAATGATCCCAGCCAGTTTGCCATTGTCACTCAATACATATCAGGGGGTTCTCTGTTCTCCCTCCTTCATGAGCAGAAGAGGA
TTCTTGATTTGCAGTCTAAATTAATTATTGCAGTAGATGTTGCCAAAGGCATGGAGTACCTTCACAACCTGACACAGCCARTTATA
CATCGTGACTTGAACAGTCACAATATTCTTCTCTATGAGGATGGGCATGCTGTGGTGGCAGATTTTGGAGAATCAAGATTTCTACA
GTCTCTGGATGAAGACAACATGACAAAACAACCTGGGAACCTCCGTTGGATGGCTCCTGAGGTGTTCACGCAGTGCACTCGGTACA
CCATCAAAGCAGATGTCTTCAGCTATGCTCTGTGTCTGTGGGAAATTCTCACTGGCGAAATTCCATTCGCTCATCTCAAGCCAGCG
GCTGCGGCAGCAGACATGGCTTACCACCACATCAGACCTCCCATTGGCTATTCCATTCCCAAGCCCATATCATCTCTGCTGATACG
AGGGTGGAACGCATGTCCTGAAGGAAGACCCGAATTTTCTGAAGTTGTCATGAAGTTAGAAGAGTGTCTCTGCAACATTGAGCTGA
TGTCTCCTGCATCAAGTAACAGCAGTGGGTCTCTCTCACCTTCTTCTTCTTCTGATTGCCTGGTGAACCGGGGAGGACCTGGCCGG
AGTCATGTGGCAGCATTAAGAAGTCGTTTCGAATTGGAATATGCTCTAAATGCAAGGTCCTATGCTGCTTTGTCCCAAAGTGCTGG
ACAATATTCCTCTCAAGGTCTGTCTTTGGAGGAGATGAAAAGAAGTCTTCAATACACACCCATTGACAAATATGGCTATGTATCCG
ATCCCATGAGCTCAATGCATTTTCATTCTTGCCGAAATAGTAGCAGCTTTGAGGACAGCAGCTGACAGCATTCGGCGTATACCTAR
GGAGAGTTTTTTCCCCGAACTGACAGCAACGATTCCAACCACGGCAAGCTGGCTTCCAACTATAACATTTTACTCTCAAAGGTCTC
CTTAAATTGGGCTTGTTTTTACTTGTCCTATTTAATTCCCCACTATTAGCAGGCTTTGGATTTGTGCCTAAGGAATAATATGCAAA
AGAACCAAGACACAATGTATATGAAGAATTGTTTTTAATTTTGTAAATTAAAAAAAAATTTAGATCGTTACTTGGAAATGGAGCCT
AAGTCTGTGGTGGACAGATAATAATTATGTTTTCCTGGGCTGAATTATGTAGACTTGTGTTTGACAGCTATGGGTTTATTTCTTAG
AACATTGTTCATTTTCTTTTCTCATTATGTTACTTCTAGTGTTCACCTCTGTGATTAAAGATTCTTTGGTGAAATAG

Following is a PCLO cDNA sequence (SEQ ID NO: 16).

>gi|37538611|ref|XM_168530.2| Homo sapiens piccolo (presynaptic cytomatrix protein)
(PCLO), mRNA
ATGACATCCTCTGGAGCCCAGAAAAAAGTTAAAAGAACTCTGCCAAATCCACCTCCTGAGGAGATTTCCACAGGAACTCAATCCAC
ATTCAGCACAATGGGCACAGTTTCCAGGAGAAGGATCTGCAGAACCAACACAATGGCACGAGCCAAGATTCTCCAGGACATAGACA
GAGAGCTTGATCTTGTGGAAAGGGAGTCTGCAAAACTTCGAAAGAAACAAGCAGAGCTTGATGAAGAAGAAAAGGAGATTGATGCT
AAGCTACGATACCTGGAAATGGGAATTAACAGGAGGAAAGAGGCCCTATTAAAGGAGAGAGAAAAGAGAGAACGAGCCTACCTCCA
GGGAGTAGCTGAGGATCGTGATTACATGTCTGACAGTGAAGTGAGTAGCACAAGACCAACCCGAATAGAAAGTCAGCATGGCATTG
AGCGACCAAGAACTGCTCCCCAAACTGAATTCAGCCAGTTTATACCACCACAAACCCAAACAGAATCTCAACTAGTTCCTCCGACA
AGTCCTTACACACAATACCAGTACTCTTCCCCTGCTCTTCCTACCCAAGCACCCACCTCATACACTCAACAGTCTCATTTTGAGCA
ACAAACTTTGTACCATCAGCAAGTTTCACCTTATCAGACTCAGCCAACATTCCAAGCTGTGGCAACAATGTCCTTCACACCTCAAG
TTCAACCTACACCAACCCCACAGCCTTCTTATCAGTTACCTTCACAGATGATGGTGATACAACAGAAGCCACGGCAAACTACATTA
TATTTGGAGCCCAAGATAACCTCAAACTATGAAGTGATTCGCAACCAACCCCTTATGATAGCACCTGTTTCTACGGATAACACATT
TGCTGTTTCCCATCTTGGTAGTAAGTACAATAGTTTAGACTTGAGAATAGGTTTGGAGGAAAGAAGTAGCATGGCAAGCAGTCCAA
TATCAAGCATATCTGCAGATTCTTTCTATGCAGATATTGATCACCATACTCCACGAAATTATGTCCTAATTGACGACATTGGAGAG
ATCACCAAAGGAACAGCGGCATTAAGCACCGCATTTAGCCTTCATGAAAAGGATCTGTCAAAAACAGACCGTCTCCTTCGAACCAC
TGAGACACGCCGGTCTCAAGAAGTGACAGATTTCCTAGCACCTTTACAGTCTTCCTCTAGATTGCATAGTTATGTGAAGGCGGAGG
AAGACCCAATGGAGGATCCTTACGAGTTAAAGCTTCTGAAACATCAGATTAAACAGGAATTTCGTAGAGGGACAGAGAGCTTAGAT
CACCTTGCTGGTCTTTCTCATTATTACCATGCTGATACTAGCTACAGACATTTTCCAAAATCTGAGAAGTATAGCATCAGTAGACT
CACACTTGAAAAACAAGCAGCAAAACAACTGCCAGCAGCCATACTTTATCAAAAGCAGTCAAAGCATAAGAAATCACTAATTGACC
CTAAAATGTCAAAATTTTCACCTATTCAAGAAACTAGAGACCTTGAACCTGATTATTCAAGCTATATGACTTCTAGCACTTCATCT
ATTGGTGGCATTTCCTCCAGGGCAAGGCTCCTTCAAGATGACATCACTTTTGGCCTCAGAAAAAATATTACAGACCAACAAAAATT
TATGGGATCTTCTCTTGGCACAGGACTGGGCACATTAGGAAATACCATACGCTCAGCTCTGCAGGATGAAGCGGATAAGCCATACA
GTAGTGGCAGCAGGTCCAGACCTTCCTCCAGACCTTCCTCTGTCTATGGGCTTGATTTATCAATTAAAAGGGATTCTTCTAGCTCT
TCCCTAAGACTGAAAGCTCAAGAGGCTGAAGCTCTAGATGTTTCCTTTAGTCATGCATCATCCTCTGCCAGAACTAAGCCGACCAG
TTTGCCAATTAGTCAAAGTAGAGGAAGAATACCAATTGTGGCCCAGAATTCTGAAGAAGAAAGCCCACTCAGTCCTGTTGGCCAGC
CAATGGGAATGGCCAGGGCTGCAGCTGGACCCCTGCCACCAATATCTGCAGACACCAGGGATCAGTTTGGATCAAGCCACTCATTG
CCTGAAGTTCAGCAACACATGAGGGAAGAATCACGGACTCGAGGCTATGACCGTGACATAGCATTCATCATGGATGACTTCCAACA
TGCCATGTCAGACAGTGAAGCCTATCATCTGCGTCGTGAGGAAACAGATTGGTTTGATAAACCCAGGGAGTCTCGTTTGGAAAATG
GACATGGTCTGGACCGAAAACTGCCGGAAAGATTGGTCCACTCTAGACCACTCAGTCAACATCAAGAGCAAATTATACAGATGAAC
GGGAAAACTATGCACTACATCTTTCCTCACGCAACGATAAAAATAACAAGAGACTCAAAGGATCACACAGTTTCAGGTAATGGATT
AGGAATTAGAATTGTGGGTGGTAAAGAAATCCCGGGACATAGTGGAGAAATTCGAGCCTATATTGCCAAGATTCTTCCTGGGGGAA
GTGCGGAACAGACCGGGAAGCTTATGGAAGGGATGCAAGTATTGGAATGGAATGGAATTCCCTTGACTTCTAAAACATATGAAGAA
GTTCAGAGTATCATTAGTCAGCAAAGTGGGGAACCAGAAATATGTGTAAGACTGGACCTCAATATGCTATCAGATTCTGAAAATTC
CCAGCATCTGGAACTTCATGAGCCACCAAAAGCTGTGGATAAGGCGAAATCCCCAGGGGTTGATCCTAAGCAGTTGGCAGCAGAAC
TCCAGAAGGTTTCACTACAGCAGTCACCGCTGGTTCTGTCATCAGTTGTTGAAAAAGGATCTCATGTTCATTCAGGTCCTACATCA
GCAGGATCCAGTTCCGTTCCCAGCCCTGGGCAACCAGGGTCCCCCTCAGTGAGCAAAAAGAAGCACGGCAGCAGCAAGCCTACCGA
TGGAACAAAGGTTGTCTCTCATCCAATTACAGGAGAAATTCAGCTTCAAATTAACTATGATCTTGGAAATCTCATAATACATATTC
TCCAAGCAAGAAATCTTGTTCCTCGAGACAACAATGGTTATTCTGACCCTTTTGTGAAAGTGTACCTTCTTCCAGGGAGAGGTCAA
GTCATGGTTGTCCAGAATGCAAGTGCTGAGTACAAGAGAAGGACTAAACATGTCCAGAAA~GTCTTAATCCTGAGTGGAATCAAAC
AGTAATTTATAAAAGTATTTCCATGGAACAGCTCAAGAAGAAAACACTGGAGGTGACAGTTTGGGATTATGATAGATTTTCATCCA
ACGACTTCCTTGGGGAGGTATTGATTGATTTATCTAGCACATCTCACCTCGATAACACTCCAAGGTGGTATCCTCTCAAAGAACAG
ACTGAAAGCATTGATCATGGCAAGTCTCATTCCAGTCAGAGCAGCCAGCAGTCCCCAAAGCCATCTGTTATCAAAAGCAGAAGCCA
TGGTATCTTCCCTGACCCATCAAAGGACATGCAGGTTCCCACCATTGAGA~ATCCCATAGTAGTCCTGGTAGCTCAAAATCATCAT
CAGAAGCCCATCTCCGTTCTCATGGACCATCTCCCAGTCAAAGCAAAACCAGCGTCACTCAGACCCACCTGGAAGATGCAGGGGCT
GCCATAGCTGCTGCCGAAGCTCCCGTGCAACAACTCCGCATTCAACCAAGTAAAAGACGCAAATAAATTCCTCAGCATGGCAGCTT
AATGTTCATCTGTTGCCTTTCTTTCCTGCTGTCCTTTCCTGTTTGCTTTCAGTTTTCAACATCCTCTGCTCACCCTGTTCTCTGTC
CCTTTGTCTGTGTAAGAACGATATAAATACATTAATATGCTCTTTCTTATTTAGATTTTTTTTATTTACATAGACTGAAATAAAAC
TGGCTGTTTCTCCTTTGTTTCCACCATCCATCCAACCTGGCTCATAGCATTTGATACAGTGTCTGTGATGTTTGGAAGCAAAGCAA
TGTTGTGTGTCCTTTTTGTTTGCGCTTAAATATCTTTTAGAATACAGAAATTATAAGCACAAGTGGCTGCCAGTTTTCCAGGACTT
ATACCAAAAAAAAAAAAGTGCACACATATAAGTATTTAGAGCAGATTTGCAATTAGATTCTTGTATCTGAAAACACTCAAAAAGTC
TAGGCAGAAGATAATGCAACCAACAGTCAACTTCTAGAACCTTGGAGGAAAAGCCATTTCAAGACAGTGCTTTAAAACACTAACAA
ATTTTGCTTCTGAAATATGGTAGCTTTCCATGTGCAAAAAATTGTAGTCTTCTGAAAAATCTGTGAAGAAAATCTTATTTCTTACA
TTCTCAAAAAACTACATTAAATTAATATATGTATAAGCATATGTGATAAGGCAATGCAACCTCACTGAGGAGCACAATTGGGTCCA
TTCTGTTGGATCACACTTTGTATGTGATGACAGATTTTACAGATATTTTTTCTAACCATTGGAAATCAAGATATACTATGTCTGGT
AGCTATAAGTCAATCAAAGTATAACAATTGACCTATCTTAACTGCTGTATTTTCATTTCATTTGTGAAAATTTAGTCGATTGATAT
AATTATATAAAAACTTAATATGTGCAAATATTTCACAAATGTAGGTACCCTGTTACTTCTAAAAGGCATTAGCCAGGCAATGGAGA
TAGATCATTGTTCTCTCCATCTCCCTAGTCATCATTTTCAAAGAAACAGCCAGTTTTAAACCCCTTTAGTGCTGTGCATGTGGTGT
CATTTTGGCATTTGAAAACACAACCTATTTAAATAGAGCAAAAGAGCACTTCTGTTTGCATGAATAACATTTAAGCTGGTTCCATC
TGAGGATACATACTCTGGGTTTCCATTTCACCCACACTGCCACAGCAGCACATAAAAGCGGTCAGTCTAATCATGCCAGGAAGCAG
CACAGACACAGCATAGCAGGAGTCCTCCCCATTCAAAGAACTCAGTCTGATAATCTGCCTCCACCAGCCAATGGCAAC
CAAGACCAAAGCCAGCTAGCCCTCAGGAAGGTGATGTCTGATGGACCAGTCAAGCCAGAAGGAGGTGAGCAGAAAGGCCCTGTTCA
AAGCACACAGCAAGAACATCCCCAAATTTAAAGCTCTCATCTTTAATTTTTAGAGATTGTCTGATAAAATATGTTTATCCACTTTT
TAATGTGCTTTTGTGGGCATGGCATTTCAGGACTTCATCATCACCATGTAAGTCCCAAGATCAGTCCCGTAATATATTGACTACAG
TGATTTGTATTTTTCTATGCACTGGGCATCTTTTGACTTTTGTTGGGAAATAGATTAACAATATTCATATTGCAGAATGGAATGCA
TGCTACTAACCTAATCTGTTCAAGCATGACTATAAATATGTTTCATTGTGATAAAAGTTTAAATTGCTCACAGTTCAAGTTAGCCT
ACCAGTTGGAATGTGGATCAGTGTTTTTTGCCTATTATTTCAAGTGTAACTTTTAAAAATTTAGTGGATTTTGAAAATTCTTAGAG
GAAAGTAAAGGAAAAATTGTTAATGCACTCATTTACCTTTACATGGTGAAAGTTCTCTCTTGATCCTACAAACAGACATTTTCCAC
TCGTGTTTCCATAGTTGTTAAGTGTATCAGATGTGTTGGGCATGTGAATCTCCAAGTGCCTGTGTAATAAATAAAGTATCTTTATT
TCATTCAT2

Following is a REPS2 cDNA sequence (SEQ ID NO: 17).

>gi|4758943|ref|NM_004726.1| Homo sapiens RALBP1 associated Eps domain containing 2
(REPS2), Mrna
CCGGGAGGAAGCGGCCGCGCGGCAGCTGCGGGGCGTGGGGGTGGTGGTGGCGGCGGCGGTGGTGGCGGCGGCGGCGGCGGCGGCAG
CTGAGGCCGAGGAGGCGGTGGCTGTGGCGGACGCAGCAGCACCCCAGCTAGGGATAGGGCTCCGCCGCGCCCCCTTGCTGGCCCCA
TGGAGGCGGCAGCGGCGGCGGCGGCGGCGGCAGCGGCAGCGGCAGCGGCGGGCGGGGGCTGTGGCTCCGGGCCGCCGCCGCTGCTG
CTGAGCGAGGGCGAGCAGCAGTGCTACTCCGAGCTCTTCGCGCGCTGTGCCGGCGCCGCGGGCGGGGGCCCCGGGTCTGGGCCCCC
CGAGGCCGCCAGAGTCGCCCCCGGCACGGCCACTGCGGCCGCCGGCCCCGTGGCTGACCTGTTTCGGGCATCGCAGCTGCCCGCCG
AGACGCTGCACCAGATCACACAACTGTGTGGTGCAAAGCGGGTTGGTTATTTTGGTCCAACACAGTTTTACATTGCCCTGAAATTA
ATTGCTGCAGCACAATCTGGCCTCCCGGTACGGATAGAGAGTATTAAATGTGAATTGCCTCTGCCTCGCTTTATGATGTCAAAGAA
TGATGGTGAGATACGATTTGGGAACCCAGCTGAGCTGCATGGAACTAAGGTTCAGATTCCATATTTAACTACAGAAAAAAATTCCT
TCAAAAGAATGGACGATGAGGATAAACAGCAGGAAACACAGTCTCCCACGATGTCACCCCTCGCCTCCCCTCCTTCTTCCCCGCCT
CATTACCAGAGGGTGCCCTTGAGCCATGGCTACAGCAAACTGCGGAGCAGCGCAGAACAGATGCATCCAGCACCTTATGAAGCTAG
GCAGCCCCTTGTCCAGCCCGAGGGATCCTCATCAGGGGGCCCAGGAACCAAGCCCCTTCGGCATCAGGCTTCCCTTATCCGGTCCT
TTTCAGTGGAGAGGGAACTACAGGATAACAGCAGTTACCCCCACGAACCCTGGAGGATAACAGAAGAACAGCGCGAGTACTATGTC
AATCAGTTCCGATCCCTTCAGCCACACCCAAGCTCTTTCATTTCAGGTTCTGTGGCCAAGAACTTCTTCACCAAATCAAAGCTTTC
CATTCCAGAACTCTCCTATATATGGGAGCTTAGTGATGCTGACTGTGATGGAGCCCTGACCCTGCCTGAGTTCTGTGCTGCGTTTC
ATCTCATTGTGGCTCGGAAGAACGGCTACCCATTGCCTGAGGGCCTCCCTCCAACTCTGCAGCCAGAATACCTGCAGGCAGCTTTT
CCTAAGCCCAAATGGGACTGTCAATTATTTGATTCTTATTCTGAGTCACTGCCGGCAAATCAACAACCTCGTGACTTGAATCGGAT
GGAGAAGACATCTGTTAAAGACATGGCTGACCTTCCTGTCCCTAACCAGGATGTAACTAGTGATGACAAACAAGCTTTGAAAAGTA
CTATCAATGAAGCCTTACCAAAGGACGTGTCTGAGGATCCAGCAACTCCCAAGGATTCCAACAGTCTCAAAGCAAGACCAAGATCC
AGATCTTACTCTAGCACCTCCATAGAAGAGGCCATGAAAAGGGGCGAGGACCCTCCCACCCCGCCACCTCGGCCACAGAAAACCCA
TTCCAGAGCCTCCTCCTTGGATCTGAATAAAGTCTTCCAGCCCAGTGTGCCAGCTACCAAGTCAGGATTGTTACCCCCACCACCTG
CGCTCCCTCCAAGACCTTGTCCATCACAGTCTGAACAAGTGTCGGAGGCCGAGTTACTCCCACAGCTGACCAGAGCCCCATCCCAG
GCTGCAGAAAGTAGTCCAGCAAAGAAGGATGTACTGTATTCTCAGCCACCATCAAAGCCCATTCGTAGGAAATTCAGACCAGAAAA
CCAAGCTACAGAAAACCAAGAGCCTTCCACTGCTGCAAGTGGGCCAGCTTCTGCGGCAACCATGAAACCGCATCCAACAGTCCAAA
AGCAGTCTTCCAAACAGAAGAAGGCCATTCAAACTGCTATCCGCAAAAATAAAGAGGCAAACGCAGTGCTGGCTCGGCTGAACAGT
GAGCTCCAGCAGCAGCTCAAGGAGGTTCATCAAGAACGAATTGCATTGGAAAACCAATTGGAACAACTTCGTCCGGTCACTGTGTT
GTGACCCCCCCATGGTTCAAGTGACAGTGGGTGACCTTGTCTGCCAAGATCTTTCTTTTGAATGTTTTGAACCCAACTACTTGTCA
TAGATGTTTGACTGTGTCAAAAGCTGTGAGCAGCAAAATATAATCCATA

Following are NRP1, NID2, ENDO180, CDK10, FPGT, CARK, PCLO and REPS2 amino acid sequences (SEQ ID NO: 18, 19, 20, 21, 22, 23, 24, 25, 26 and 27, respectively). Following is a NRP1 amino acid sequence (SEQ ID NO: 18).

>gi|4505457|ref|NP_003864.1| neuropilin 1 [Homo sapiens]
MERGLPLLCAVLALVLAPAGAFRNDECGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKLAPPPVVSSGPFLF
IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPK
MSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGI
LSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNW
SAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYK
IDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKYLITRFVRIKPATWETGISMRF
EVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENLRLVTSRSGWALPPAPH
SYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKA
KSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNG
NLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGS
HKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVV
YSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRV
LLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGS
TPGYEGEGEGDKNISRKPGNVLKTLEPILITIIAMSALGVLLGAVCGVVLYCACWHNGM
SERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA

The following Table shows polypeptide domain regions in a NRP1 amino acid sequence.

			AA
	Prediction	Accession	start	AA	Domain
	method	id	site	end	description
	prints	PR00020	692	708	MAM_domain
	prints	PR00020	720	731	MAM_domain
	prints	PR00020	769	783	MAM_domain
	prints	PR00020	788	801	MAM_domain
	Pfam	PF00431	27	138	CUB_domain
	Pfam	PF00431	147	262	CUB_domain
	Pfam	PF00754	278	421	FA58_C
	Pfam	PF00754	434	580	FA58_C
	Pfam	PF00629	650	811	MAM_domain
	prosite	PS00740	690	730	MAM_domain
	prosite	PS01285	314	343	FA58_C
	prosite	PS01285	470	502	FA58_C
	prosite	PS01286	408	424	FA58_C
	prosite	PS01286	566	583	FA58_C
	pfscan	PS01180	27	141	CUB_domain
	pfscan	PS01180	147	256	CUB_domain

Following is a NID2 amino acid sequence (SEQ ID NO: 19).

>gi|33469989|ref|NP_031387.2| nidogen 2; osteonidogen [Homo sapiens]
MEGDRVAGRPVLSSLPVLLLLQLLMLRAAALHPDELFPHGESWGDQLLQEGDDESSAV
VKLANPLHFYEARFSNLYVGTNGIISTQDFPRETQYVDYDFPTDFPAIAPFLADIDTSHGR
GRVLYREDTSPAVLGLAARYVRAGFPRSARFTPTHAFLATWEQVGAYEEVKRGALPSG
ELNTFQAVLASDGSDSYALFLYPANGLQFLGTRPKESYNVQLQLPARVGFCRGEADDL
KSEGPYFSLTSTEQSVKNLYQLSNLGIPGVWAFHIGSTSPLDNVRPAAVGDLSAAHSSVP
LGRSFSHATALESDYNEDNLDYYDVNEEEAEYLPGEPEEALNGHSSIDVSFQSKVDTKP
LEESSTLDPHTKEGTSLGEVGGPDLKGQVEPWDERETRSPAPPEVDRDSLAPSWETPPP
YPENGSIQPYPDGGPVPSEMDVPPAHPEEEIVLRSYPASGHTTPLSRGTYEVGLEDNIGS
NTEVFTYNAANKETCEHNHRQCSRHAFCTDYATGFCCHCQSKFYGNGKHCLPEGAPH
RVNGKVSGHLHVGHTPVHFTDVDLHAYIVGNDGRAYTAISHIPQPAAQALLPLTPIGGL
FGWLFALEKPGSENGFSLAGAAFTHDMEVTFYPGEETVRITQTAEGLDPENYLSIKTNIQ
GQVPYVPANFTAHISPYKELYHYSDSTVTSTSSRDYSLTFGANQTWSYRIHQNITYQVC
RHAPRHPSFPTTQQLNVDRVFALYNDEERVLRFAVTNQIGPVKEDSDPTPGNPCYDGSH
MCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLPGSY
RCECRSGYEFADDRHTCILITPPANPCEDGSHTCAPAGQARCVHHGGSTFSCACLPGYA
GDGHQCTDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQ
QRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQTPPGST
PPHCGPSPEPTQRPPTICERWRENLLEHYGGTPRDDQYVPQCDDLGHFLPLQCHGKSDFC
WCVDKDGREVQGTRSQPGTTPACIPTVAPPMVRPTPRPDVTPPSVGTFLLYTQGQQIGY
LPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETI
VNSGLISPEGLAIDHIRRTMYWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIR
GNLYWTDWNREAPKIETSSLDGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLE
CTLPDGTGRRVIQNNLKYPFSIVSYADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQR
SHLYGITAVYPYCPTGRK

The following Table shows domain regions in a NID2 amino acid sequence.

		AA
Prediction	Accession	start	AA	DOMAIN
method	id	site	end	DESCRIPTION
Pfam	PF00008	763	799	EGF_like
Pfam	PF00008	805	842	EGF_like
Pfam	PF00008	852	890	EGF_like
Pfam	PF00008	896	929	EGF_like
Pfam	PF00086	940	1005	Thyroglobulin_1
Pfam	PF00086	1019	1084	Thyroglobulin_1
Pfam	PF00058	1154	1196	Ldl_receptor_rep
Pfam	PF00058	1198	1239	Ldl_receptor_rep
Pfam	PF00058	1241	1284	Ldl_receptor_rep
Pfam	PF00058	1286	1326	Ldl_receptor_rep
prosite	PS00010	501	512	Asx_hydroxyl
prosite	PS00010	818	829	Asx_hydroxyl
prosite	PS00010	907	918	Asx_hydroxyl
prosite	PS00484	959	988	Thyroglobulin_1
prosite	PS00484	1039	1068	Thyroglobulin_1
prosite	PS01186	786	799	EGF_like
prosite	PS01186	827	842	EGF_like
prosite	PS01186	877	890	EGF_like
prosite	PS01186	916	929	EGF_like
prosite	PS01187	801	827	EGF_Ca
prosite	PS01187	892	916	EGF_Ca

Following is a ENDO180 amino acid sequence (SEQ ID NO: 20).

>gi|5174485|ref|NP_006030.1| mannose receptor, C type 2
MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQG
GQVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTNTLTASLGMYECDRE
ALNLRWHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHE
VYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKS
NDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTG
YSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNR
DCSIALPYVCKKKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEKRSWQESK
KACLRGGGDLVSIHSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTH
WHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRK
GWTWHSPSCYWLGEDQVTYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFW
TALQDLNSTGSFFWLSGDEVMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTS
FRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKS
WVQAQGACQELGAQLLSLASYEEEHFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPR
GGQSWRWSDGVGFSYHNFDRSRHDDDDIRGCAVLDLASLQWVAMQCDTQLDWICKIP
RGTDVREPDDSPQGRREWLRFQEAEYKFFEHHSTWAQAQRICTWFQAELTSVHSQAEL
DFLSHNLQKFSRAQEQHWWIGLHTSESDGRFRWTDGSIINFISWAPGKPRPVGKDKKCV
YMTASREDWGDQRCLTALPYICKRSNVTKETQPPDLPTTALGGCPSDWIQFLNKCFQV
QGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQAFITASLPNVTFDLWIGLHASQRDF
QWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAVVLHSPSAHFTGRWDDRSCTEETH
GFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLLQKPLRWHDALLLCESHNASLAYV
PDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVSEEPLNYVGWQDGEPQQPGGCT
YVDVDGAWRTFfSCDTKLQGAVCGVSSGPPPPRRISYHGSCPQGLADSAWJPFREHCYSF
HMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQSYEGQSRGAWLGMNFNP
KGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGLWRPGACTNITMGVV
CKLPRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQSIERGAFEGARY
SRSSSSPTEATEKNILVSDMEMNEQQE

The following Table shows domain regions in an ENDO180 amino acid sequence.

		AA
Prediction	Accession	start	AA	DOMAIN
method	id	site	end	DESCRIPTION
prints	PR00356	381	393	AntifreezeII
prints	PR00356	393	410	AntifreezeII
prints	PR00356	411	428	AntifreezeII
prints	PR00356	441	457	AntifreezeII
prints	PR00356	491	504	AntifreezeII
prints	PR00013	184	193	FN_Type_II
prints	PR00013	195	207	FN_Type_II
prints	PR00013	212	227	FN_Type_II
Pfam	PF00040	187	228	FN_Type_II
Pfam	PF00059	255	361	Lectin_C
Pfam	PF00059	399	506	Lectin_C
Pfam	PF00059	538	646	Lectin_C
Pfam	PF00059	693	810	Lectin_C
Pfam	PF00059	842	952	Lectin_C
Pfam	PF00059	993	1109	Lectin_C
Pfam	PF00059	1142	1245	Lectin_C
Pfam	PF00059	1284	1395	Lectin_C
prosite	PS00023	187	228	FN_Type_II
prosite	PS00213	1219	1232	Lipocln_cytFABP
prosite	PS00615	335	359	Lectin_C
prosite	PS00615	481	504	Lectin_C
prosite	PS00615	927	950	Lectin_C
pfscan	PS50231	54	121	Ricin_B_lectin

Following is a first CDK10 amino acid sequence (SEQ ID NO: 21).

>gi|32528263|ref|NP_003665.2| cyclin-dependent kinase 10 isoform 1; serine/threonine
protein kinase PISSLRE; CDC2-related protein kinase; cell division protein kinase 10;
cyclin-dependent kinase related protein [Homo sapiens]
MGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEJVALKKVRMDKEKDGIPISSLREITL
LLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVL
RGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYR
APELLLGTFLTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGF
SKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFK
EKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKIP

Following is a third CDK10 amino acid sequence (SEQ ID NO: 23).

>gi|32528266|ref|NP_443714.2| cyclin-dependent kinase 10 isoforra 3; serine/threonine
protein kinase PISSLRE; CDC2-related protein kinase; cell division protein kinase 10;
cyclin-dependent kinase related protein [Homo sapiens]
MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM
PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTGGCNLGQALSL
DGTW

Following is a FPGT amino acid sequence (SEQ ID NO: 24).

>gi|4503777|ref|NP_003829.1| fucose-1-phosphate guanyltransferase; GDP-beta-L-fucose
pyrophosphorylase [Homo sapiens]
MAAARDPPEVSLREATQRKLRRFSELRGKLVARGEFWDIVAITAADEKQELAYNQQLS
EKLKRKELPLGVQYHVFVDPAGAKIGNGGSTLCALQCLEKLYGDKWNSFTILLIHSGGY
SQRLPNASALGKIFTALPLGNPIYQMLELKLAMYIDFPLNMNPGILVTCADDIELYSIGEF
EFIRFDKPGFTALAHPSSLTIGTTHGVFVLDPFDDLKHRDLEYRSCHRFLHKPSIEKMYQ
FNAVCRPGNFCQQDFAGGDIADLKLDSDYVYTDSLFYMDHKSAKMLLAFYEKIGTLSC
EIDAYGDFLQALGPGATVEYTRNTSHVIKEESELVEMRQRIFHLLKGTSLNVVVLNNSK
FYHIGTTEEYLFYFTSDNSLKSELGLQSITFSIFPDLPECSGKTSCIIQSILDSRCSVAPGSVV
EYSRLGPDVSVGENCIISGSYILTKAALPAHSFVCSLSLKMNRCLKYATMAFGVQDNLK
KSXTKTLSDIKLLQFFGVCFLSCLDVWNLKVTEELFSGNKTCLSLWTARIFPVCSSLSDSVI
TSLKMLNAVKNKSAFSLNSYKLLSIEEMLIYKDVEDMITYREQIFLEISLKSSLM

Following is a CARK amino acid sequence (SEQ ID NO: 25).

>gi|7705748|ref|NP_057062.1| cardiac ankyrin repeat kinase [Homo sapiens]
MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRMFGSDEAFSKVNL
NYRTENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSL
LHSGADIQQVGYGGLTALHIATLAGHLEAADVLLQHGANVNIQDAVFFTPLHJAAYYGH
EQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDH
VPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE
SLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLV
QFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPC
NEYSQPGGDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSF
GKVYKGRCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPS
QFAIVTQYISGGSLFSLLHEQKRILDLQSKLIJAVDVAKGMEYLHNLTQPIIHRDLNSHNI
LLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSY
ALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEF
SEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYA
LNARSYAALSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSF
EDSS

Following is a PCLO amino acid sequence (SEQ ID NO: 26).

MTSSGAQKKVKRTLPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDREL
DLVERESAKLRKKQAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVA
EDRDYMSDSEVSSTRPTRIESQHGIERPRTAPQTEFSQFIPPQTQTESQLVPPTSPYTQY
QYSSPALPTQAPTSYTQQSHFEQQTLYHQQVSPYQTQPTFQAVATMSFTPQVQPTPTPQP
SYQLPSQMMVIQQKPRQTTLYLEPKITSNYEVIRNQPLMIAPVSTDNTFAVSHLGSKYNS
LDLRIGLEERSSMASSPISSISADSFYADIDHHTPRNYVLIDDIGEITKGTAALSTAFSL
HEKDLSKTDRLLRTTETRRSQEVTDFLAPLQSSSRLHSYVKAEEDPMEDPYELKLLKHQI
KQEFRRGTESLDHLAGLSHYYHADTSYRHFPKSEKYSISRLTLEKQAAKQLPAAILYQKQ
SKHKKSLIDPKMSKFSPIQESRDLEPDYSSYMTSSTSSIGGISSRARLLQDDITFGLRKN
ITDQQKFMGSSLGTGLGTLGNTIRSALQDEADKPYSSGSRSRPSSRPSSVYGLDLSIKRD
SSSSSLRLKAQEAEALDVSFSHASSSARTKPTSLPISQSRGRIPIVAQNSEEESPLSPVG
QPMGMARAAAGPLPPISADTRDQFGSSHSLPEVQQHMREESRTRGYDRDIAFIMDDFQHA
MSDSEAYHLRREETDWFDKPRESRLENGHGLDRKLPERLVHSRPLSQHQEQIIQMNGKTM
HYIFPHARIKITRDSKDHTVSGNGLGIRLVGGKEIPGHSGEIGAYIAKILPGGSAEQTGK
IMEGMQVLEWNGIPLTSKTYEEVQSIISQQSGEAEICVRLDLNMLSDSENSQHLELHEPP
KAVDKAKSPGVDPKQLAAELQKVSLQQSPLVLSSVVEKGSHVHSGPTSAGSSSVPSPGQP
GSPSVSKKKHGSSKPTDGTKVVSHPITGEIQLQINYDLGNLIIHILQARNLVPRDNNGYS
DPFVKVYLLPGRGQVMVVQNASAEYKRRTKHVQKSLNPEWNQTVJYKSISMEQLKKKTLE
VTVWDYDRFSSNDFLGEVLIDLSSTSHLDNTPRWYPLKEQTESIDHGKSHSSQSSQQSPK
PSVIKSRSHGWPDPSKDMQVPTIEKSHSSPGSSKSSSEGHLRSHGPSRSQSKTSVTQTHL
EDAGAAIAAAEAAVQQLRIQPSKRRK

Following is a REPS2 amino acid sequence (SEQ ID NO: 27)

>gi|4758944|ref|NP_004717.1| RALBP1 associated Eps domain containing 2; partner of
Ral-binding protein 1 [Homo sapiens]
MMSKNDGELRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQQETQSPTMSPLASPPS
SPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPLRHQASLIRS
FSVERELQDNSSYPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPE
LSYIWELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKW
DCQLFDSYSESLPANQQPRDLNRMEKTSVKDMADLPVPNQDVTSDDKQALKSTINEAL
PKDVSEDPATPKDSNSLKARPRSRSYSSTSIEEAMKRGEDPPTPPPRPQKTHSRASSLDLN
KVFQPSVPATKSGLLPPPPALPPRPCPSQSEQVSEAELLPQLSRAPSQAAESSPAKKDVLY
SQPPSKPIRRKFRPENQATENQEPSTAASGPASAATMKPHPTVQKQSSKQKKAIQTAIRK
NKEANAVLARLNSELQQQLKEVHQERIALENQLEQLRPVTVL

Modifications may be made to the foregoing without departing from the basic aspects of the invention. Although the invention has been described in substantial detail with reference to one or more specific embodiments, those of skill in the art will recognize that changes may be made to the embodiments specifically disclosed in this application, yet these modifications and improvements are within the scope and spirit of the invention, as set forth in the claims which follow. Also, citation of the above publications or documents is not intended as an admission that any of the foregoing is pertinent prior art, nor does it constitute any admission as to the contents or date of these publications or documents. U.S. patents and other publications and documents referenced are incorporated herein by reference.

Claims

1. A method for identifying a subject at risk of melanoma, which comprises detecting the presence or absence of a polymorphic variation associated with melanoma at one or more positions selected from the group consisting of rs6481845, rs10643659, rs7475391, rs7475394, rs7475396, rs9418057, rs5784335, rs2429390, rs7209331, rs4968706, rs8072984, rs9896444, rs4968617, rs7350907, rs8072519, rs6467914, rs3064869, rs10555175, rs6956848, position 63624 in SEQ ID NO: 6, position 65039 in SEQ ID NO: 6, rs489941, rs496008, rs4650251, rs531412, rs3765654, rs6660350, position 206 in SEQ ID NO: 5, rs5924619, rs5924564, rs4828523, rs5924569, rs2052763, rs1549529, rs5924573, rs4240072, rs5924580, rs4828544, rs5969758, rs1965051, rs1426800, rs1365529, rs5924545, rs5969761, rs6629202, rs5924584, rs1365530, rs6527769, rs2382813, rs2033120, rs2162394, rs1346246, rs1365527, rs4828524, rs5924588, rs5969764, rs5924589, rs5924590, rs5924593, rs4828547, rs5969768, rs4828526, rs5924595, rs5924549, rs5969769, rs4007744, rs2891073, rs5924599, rs1549531, rs5924601, rs5901609, rs5969739, rs5924602, rs1426798, rs4828550, rs5924603, rs1807947, rs2382814, rs5924606 and position 25216 in SEQ ID NO: 7; whereby the presence of the one or more polymorphic variations is indicative of the subject being at risk of melanoma.

2. The method of claim 1, which further comprises obtaining the nucleic acid sample from the subject.

3. The method of claim 1, wherein a polymorphic variation is detected at one or more positions selected from the group consisting of rs6481845, rs10643659, rs7475391, rs7475394, rs7475396, rs9418057 and rs5784335.

4. The method of claim 1, wherein a polymorphic variation is detected at one or more positions selected from the group consisting of rs2429390, rs7209331, rs4968706, rs8072984, rs9896444, rs4968617, rs7350907 and rs8072519.

5. The method of claim 1, wherein a polymorphic variation is detected at one or more positions selected from the group consisting of rs6467914, rs3064869, rs10555175, rs6956848, position 63624 in SEQ ID NO: 6 and position 65039 in SEQ ID NO: 6.

6. The method of claim 1, wherein a polymorphic variation is detected at one or more positions selected from the group consisting of rs489941, rs496008, rs4650251, rs531412, rs3765654, rs6660350 and position 206 in SEQ ID NO: 5.

7. The method of claim 1, wherein a polymorphic variation is detected at one or more positions selected from the group consisting of rs5924619, rs5924564, rs4828523, rs5924569, rs2052763, rs1549529, rs5924573, rs4240072, rs5924580, rs4828544, rs5969758, rs1965051, rs1426800, rs1365529, rs5924545, rs5969761, rs6629202, rs5924584, rs1365530, rs6527769, rs2382813, rs2033120, rs2162394, rs1346246, rs1365527, rs4828524, rs5924588, rs5969764, rs5924589, rs5924590, rs5924593, rs4828547, rs5969768, rs4828526, rs5924595, rs5924549, rs5969769, rs4007744, rs2891073, rs5924599, rs1549531, rs5924601, rs5901609, rs5969739, rs5924602, rs1426798, rs4828550, rs5924603, rs1807947, rs2382814, rs5924606 and position 25216 in SEQ ID NO: 7.

8. The method of claim 1, wherein one or more polymorphic variations are detected at one or more positions in linkage disequilibrium with a polymorphic variation at one or more of the positions in claim 1.

9. The method of claim 1, wherein detecting the presence or absence of the one or more polymorphic variations comprises: hybridizing an oligonucleotide to the nucleic acid sample, wherein the oligonucleotide is complementary to a nucleotide sequence in the nucleic acid and hybridizes to a region adjacent to the polymorphic variation; extending the oligonucleotide in the presence of one or more nucleotides, yielding extension products; and detecting the presence or absence of a polymorphic variation in the extension products.

10. The method of claim 1, wherein the subject is a human.

11. A method for identifying a polymorphic variation associated with melanoma proximal to an incident polymorphic variation associated with melanoma, which comprises: identifying a polymorphic variation proximal to the incident polymorphic variation associated with melanoma, wherein the incident polymorphic variation is at a position selected from the group consisting of rs6481845, rs10643659, rs7475391, rs7475394, rs7475396, rs9418057, rs5784335, rs2429390, rs7209331, rs4968706, rs8072984, rs9896444, rs4968617, rs7350907, rs8072519, rs6467914, rs3064869, rs10555175, rs6956848, position 63624 in SEQ ID NO: 6, position 65039 in SEQ ID NO: 6, rs489941, rs496008, rs4650251, rs531412, rs3765654, rs6660350, position 206 in SEQ ID NO: 5, rs5924619, rs5924564, rs4828523, rs5924569, rs2052763, rs1549529, rs5924573, rs4240072, rs5924580, rs4828544, rs5969758, rs1965051, rs1426800, rs1365529, rs5924545, rs5969761, rs6629202, rs5924584, rs1365530, rs6527769, rs2382813, rs2033120, rs2162394, rs1346246, rs1365527, rs4828524, rs5924588, rs5969764, rs5924589, rs5924590, rs5924593, rs4828547, rs5969768, rs4828526, rs5924595, rs5924549, rs5969769, rs4007744, rs2891073, rs5924599, rs1549531, rs5924601, rs5901609, rs5969739, rs5924602, rs1426798, rs4828550, rs5924603, rs1807947, rs2382814, rs5924606 and position 25216 in SEQ ID NO: 7; and determining the presence or absence of an association of the proximal polymorphic variant with melanoma.

12. The method of claim 11, wherein the proximal polymorphic variation is within a region between about 5 kb 5′ of the incident polymorphic variation and about 5 kb 3′ of the incident polymorphic variation.

13. The method of claim 11, which further comprises determining whether the proximal polymorphic variation is at a position in linkage disequilibrium with the incident polymorphic variation.

14. The method of claim 11, which further comprises identifying a second polymorphic variation proximal to the identified proximal polymorphic variation associated with melanoma and determining if the second proximal polymorphic variation is associated with melanoma.

15. The method of claim 14, wherein the second proximal polymorphic variant is within a region between about 5 kb 5′ of the incident polymorphic variation and about 5 kb 3′ of the proximal polymorphic variation associated with melanoma.

16. An isolated nucleic acid which comprises a portion of or all of a nucleotide sequence in SEQ ID NO: 3, 4, 5, 6 and/or 7 and comprises one or more polymorphic variations selected from the group consisting of an adenine at position 16727 in SEQ ID NO: 3, a guanine at position 36589 in SEQ ID NO: 4, a thymine at position 44544 in SEQ ID NO: 4, a guanine at position 48304 in SEQ ID NO: 4, a guanine at position 53843 in SEQ ID NO: 6, a guanine at position 63624 in SEQ ID NO: 6, an adenine-thymine deletion at position 65039 in SEQ ID NO: 6, a guanine at position 206 in SEQ ID NO: 5, an adenine at position 9261 in SEQ ID NO: 5, a thymine at position 37592 in SEQ ID NO: 5, a guanine at position 10537 in SEQ ID NO: 7, a cytosine at position 25216 in SEQ ID NO: 7 and a thymine at position 119368 in SEQ ID NO: 7.

17. The isolated nucleic acid of claim 16, which comprises an adenine at position 16727 in SEQ ID NO: 3.

18. The isolated nucleic acid of claim 16, which comprises a polymorphic variation selected from the group consisting of a guanine at position 36589 in SEQ ID NO: 4, a thymine at position 44544 in SEQ ID NO: 4, a guanine at position 48304 in SEQ ID NO: 4.

19. The isolated nucleic acid of claim 16, which comprises a polymorphic variation selected from the group consisting of a guanine at position 53843 in SEQ ID NO: 6, a guanine at position 63624 in SEQ ID NO: 6, an adenine-thymine deletion at position 65039 in SEQ ID NO: 6.

20. The isolated nucleic acid of claim 16, which comprises a polymorphic variation selected from the group consisting of a guanine at position 206 in SEQ ID NO: 5, an adenine at position 9261 in SEQ ID NO: 5, a thymine at position 37592 in SEQ ID NO: 5.

21. The isolated nucleic acid of claim 16, which comprises a polymorphic variation selected from the group consisting of a guanine at position 10537 in SEQ ID NO: 7, a cytosine at position 25216 in SEQ ID NO: 7 and a thymine at position 119368 in SEQ ID NO: 7.

22. An oligonucleotide comprising a nucleotide sequence complementary to a portion of the nucleotide sequence of claim 16, wherein the 3′ end of the oligonucleotide is adjacent to a polymorphic variation.

23. A microarray comprising an isolated nucleic acid of claim 16 linked to a solid support.

24. An isolated polypeptide encoded by the isolated nucleic acid sequence of claim 16.

25. A method of genotyping a nucleic acid at a position selected from the group consisting of position 16727 in SEQ ID NO: 3, position 36589 in SEQ ID NO: 4, position 44544 in SEQ ID NO: 4, position 48304 in SEQ ID NO: 4, position 53843 in SEQ ID NO: 6, position 63624 in SEQ ID NO: 6, position 65039 in SEQ ID NO: 6, position 206 in SEQ ID NO: 5, position 9261 in SEQ ID NO: 5, position 37592 in SEQ ID NO: 5, position 10537 in SEQ ID NO: 7, position 25216 in SEQ ID NO: 7 and position 119368 in SEQ ID NO: 7.

26. The method of claim 25, which comprises genotyping the nucleic acid at position 16727 in SEQ ID NO: 3.

27. The method of claim 25, which comprises genotyping the nucleic acid at a position selected from the group consisting of position 36589 in SEQ ID NO: 4, position 44544 in SEQ ID NO: 4 and position 48304 in SEQ ID NO: 4.

28. The method of claim 25, which comprises genotyping the nucleic acid at a position selected from the group consisting of position 53843 in SEQ ID NO: 6, position 63624 in SEQ ID NO: 6 and position 65039 in SEQ ID NO: 6.

29. The method of claim 25, which comprises genotyping the nucleic acid at a position selected from the group consisting of position 206 in SEQ ID NO: 5, position 9261 in SEQ ID NO: 5 and position 37592 in SEQ ID NO: 5.

30. The method of claim 25, which comprises genotyping the nucleic acid at a position selected from the group consisting of position 10537 in SEQ ID NO: 7, position 25216 in SEQ ID NO: 7 and position 119368 in SEQ ID NO: 7.

31. A method for identifying a candidate molecule that modulates cell proliferation, which comprises: (a) introducing a test molecule to a system which comprises one or more cells and a a nucleic acid comprising one or more polymorphic variations at one or more positions selected from the group consisting of rs6481845, rs10643659, rs7475391, rs7475394, rs7475396, rs9418057, rs5784335, rs2429390, rs7209331, rs4968706, rs8072984, rs9896444, rs4968617, rs7350907, rs8072519, rs6467914, rs3064869, rs10555175, rs6956848, position 63624 in SEQ ID NO: 6, position 65039 in SEQ ID NO: 6, rs489941, rs496008, rs4650251, rs531412, rs3765654, rs6660350, position 206 in SEQ ID NO: 5, rs5924619, rs5924564, rs4828523, rs5924569, rs2052763, rs1549529, rs5924573, rs4240072, rs5924580, rs4828544, rs5969758, rs1965051, rs1426800, rs1365529, rs5924545, rs5969761, rs6629202, rs5924584, rs1365530, rs6527769, rs2382813, rs2033120, rs2162394, rs1346246, rs1365527, rs4828524, rs5924588, rs5969764, rs5924589, rs5924590, rs5924593, rs4828547, rs5969768, rs4828526, rs5924595, rs5924549, rs5969769, rs4007744, rs2891073, rs5924599, rs1549531, rs5924601, rs5901609, rs5969739, rs5924602, rs1426798, rs4828550, rs5924603, rs1807947, rs2382814, rs5924606 and position 25216 in SEQ ID NO: 7; and (b) determining whether cell proliferation is increased or decreased compared to a system not containing the test molecule, whereby a increased or decreased cell proliferation identifies the test molecule as a candidate molecule that modulates cell proliferation.

32. The method of claim 31, wherein the system is an animal.

33. The method of claim 31, wherein the system is one or more cells.

34. A method for treating melanoma in a subject, which comprises administering a candidate molecule identified by the method of claim 31 to a subject in need thereof, whereby the candidate molecule treats melanoma in the subject.

35. A method for treating melanoma in a subject or preventing melanoma in a subject, which comprises detecting the presence or absence of one or more polymorphic variations at one or more positions selected from the group consisting of rs6481845, rs10643659, rs7475391, rs7475394, rs7475396, rs9418057, rs5784335, rs2429390, rs7209331, rs4968706, rs8072984, rs9896444, rs4968617, rs7350907, rs8072519, rs6467914, rs3064869, rs10555175, rs6956848, position 63624 in SEQ ID NO: 6, position 65039 in SEQ ID NO: 6, rs489941, rs496008, rs4650251, rs531412, rs3765654, rs6660350, position 206 in SEQ ID NO: 5, rs5924619, rs5924564, rs4828523, rs5924569, rs2052763, rs1549529, rs5924573, rs4240072, rs5924580, rs4828544, rs5969758, rs1965051, rs1426800, rs1365529, rs5924545, rs5969761, rs6629202, rs5924584, rs1365530, rs6527769, rs2382813, rs2033120, rs2162394, rs1346246, rs1365527, rs4828524, rs5924588, rs5969764, rs5924589, rs5924590, rs5924593, rs4828547, rs5969768, rs4828526, rs5924595, rs5924549, rs5969769, rs4007744, rs2891073, rs5924599, rs1549531, rs5924601, rs5901609, rs5969739, rs5924602, rs1426798, rs4828550, rs5924603, rs1807947, rs2382814, rs5924606 and position 25216 in SEQ ID NO: 7; and administering a melanoma treatment or administering a melanoma preventative to a subject in need thereof based upon the presence or absence of the one or more polymorphic variations in the nucleic acid sample.

36. The method of claim 35, wherein the one or more polymorphic variations is at one or more positions selected from the group consisting of rs6481845, rs10643659, rs7475391, rs7475394, rs7475396, rs9418057 and rs5784335.

37. The method of claim 35, wherein the one or more polymorphic variations is at one or more positions selected from the group consisting of rs2429390, rs7209331, rs4968706, rs8072984, rs9896444, rs4968617, rs7350907 and rs8072519.

38. The method of claim 35, wherein a polymorphic variation is at position rs8404.

39. The method of claim 35, wherein the one or more polymorphic variations is at one or more positions selected from the group consisting of rs6467914, rs3064869, rs10555175, rs6956848, position 63624 in SEQ ID NO: 6 and position 65039 in SEQ ID NO: 6.

40. The method of claim 35, wherein the one or more polymorphic variations is at one or more positions selected from the group consisting of rs489941, rs496008, rs4650251, rs531412, rs3765654, rs6660350 and position 206 in SEQ ID NO: 5.

41. The method of claim 35, wherein the one or more polymorphic variations is at one or more positions selected from the group consisting of rs5924619, rs5924564, rs4828523, rs5924569, rs2052763, rs1549529, rs5924573, rs4240072, rs5924580, rs4828544, rs5969758, rs1965051, rs1426800, rs1365529, rs5924545, rs5969761, rs6629202, rs5924584, rs1365530, rs6527769, rs2382813, rs2033120, rs2162394, rs1346246, rs1365527, rs4828524, rs5924588, rs5969764, rs5924589, rs5924590, rs5924593, rs4828547, rs5969768, rs4828526, rs5924595, rs5924549, rs5969769, rs4007744, rs2891073, rs5924599, rs1549531, rs5924601, rs5901609, rs5969739, rs5924602, rs1426798, rs4828550, rs5924603, rs1807947, rs2382814, rs5924606 and position 25216 in SEQ ID NO: 7.

42. The method of claim 35, which further comprises extracting and analyzing a tissue biopsy sample from the subject.

43. The method of claim 35, wherein the treatment is one or more selected from the group consisting of administering cisplatin, administering carmustine, administering vinblastine, administering vincristine, administering bleomycin, administering a combination of the foregoing, and surgery.

44. The method of claim 35, wherein the preventative reduces ultraviolet (UV) light exposure to the subject.