Bohm I., et al. (1998). “Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension,” Chemistry and Biology 5 (6):407-412. |
Haydock et al. (1995) FEBS Letters 374:246-248. |
Kakavas et al. (1997) 179(23):7515-7522. |
Kao, C.M. et al. (1996). “Evidence for two catalitycally independent clusters of active sites in a functional modular polyketide synthase,” Biochemistry 35(38):12363-12368. |
Katz, L. (1997). “Manipulation of modular polyketide synthases,” Chemical Reviews 97(7):2557-2575. |
Khosla (1977) Chem. Rev. 97:2577-2590. |
Khosla, C. et al. (1999). “Tolerance and specificity of polyketide synthases,” Annual Review of Biochemistry 68:219-253. |
Kuhstoss, S. et al. (1996). “Production of a novel polyketide through the construction of a hybrid polyketide synthase,” Gene 183(1):231-236. |
Lau et al., 1999, “Dissecting the Role of Acyltransferase Domains of Modular Polyketide Synthases in the Choice and Stereochemical Fate of Extender Units”, Biochemistry 38(5):1643-51. |
Lau, J. et al. (1998). “Dissecting and manipulating substrate specificity of the acyltransferase domains of modular polyketide synthases,” Book of Abstracts, 216th ACS National Meeting, Boston, Aug. 23-27,BTEC-028. |
Marsden, A.F. et al. (1994). “Stereospecific acyl transfers on the erythromycin-producing polyketide synthase,” Science 263(5145):378-380. |
Miller, W.W. et al. (1968). “N-acetyl-S-methylmalonylcysteamine, an inhibitor of methylmalonyl coenzyme A isomerase,” Biochem Biophys Res Commun 33(4):1569-1573. |
Motamedi et al. (1997) Eur. J. Biochem. 244:74-80. |
Oliynyk et al. (1996) Chem. & Biol. 3:833-839. |
Pohl et al., 1998, “Synthesis and Incorporation of an N-Acetylcysteamine Analogue of Methylmalonyl-CoA by a Modular Polyketide Synthase”, J. Am. Chem. Soc., 120:11206-7. |
Ruan et al. (1997) J. Bacteriol. 179(20):6416-6425. |
Schwecke et al. (1995) “The Biosynthetic Gene Cluster for the Polyketide Immunosuppressant Rapamycin,” PNAS,92:7839-7843. |
Staunton et al. (1997) Chem. Rev. 97(7):2611-2630. |
Stassi, D.L. et al. (1998). “Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering,” Proc Natl Acad Sci USA 95(13):7305-7309. |
Weissman, K.J. et al. (1997). “The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase,” Biochemistry 36(45):13849-13855. |