Claims
- 1. A method for detecting malignant ovarian or prostate hyperplasia in a biological sample, comprising the steps of:(a) isolating mRNA from said sample; and (b) detecting hepsin mRNA in said sample, wherein over-expression of said hepsin mRNA in said sample compared to normal tissue sample is indicative of the presence of malignant ovarian or prostate hyperplasia.
- 2. The method of claim 1, wherein said detection of said hepsin mRNA is by PCR amplification.
- 3. The method of claim 2, wherein said PCR amplification uses primers selected from the group consisting of SEQ ID No. 8 and SEQ ID No. 9.
- 4. The method of claim 1, wherein said biological sample is selected from the group consisting of blood, interstitial fluid, ascites fluid, tumor tissue biopsy and circulating tumor cells.
Parent Case Info
This is a divisional application of U.S. Ser. No. 09/510,738 filed on Feb. 22, 2000, now U.S. Pat. No. 6,268,165 B1, which is a continuation-in-part application of U.S. Ser. No. 09/039,211, filed Mar. 14, 1998 now U.S. Pat. No. 6,303,318, which claims the benefit of priority under 35 USC §119(e) of provisional application No. 60/041,404 filed on Mar. 19, 1997, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5484726 |
Basset et al. |
Jan 1996 |
A |
Non-Patent Literature Citations (3)
Entry |
Castro et al., Thrombosis-Predisposing Causes and Clinical Management, Blood (1996) 88 (Suppl) 179A.* |
Tanimoto et al. Jan./Feb. 1997. Society for Gynecological Research. vol. 14 Abstract 577.* |
Torres-Rosado et al. Proceedings of the National Academy ofScies. 1993. 90: 7181-7185. |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/041404 |
Mar 1997 |
US |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09/039211 |
Mar 1998 |
US |
Child |
09/510738 |
|
US |