Claims
- 1. A method for detecting malignant ovarian hyperplasia in a biological sample, comprising the steps of:(a) isolating mRNA from said sample; and (b) detecting stratum corneum chymotrytic enzyme mRNA in said sample, wherein increased expression of said stratum corneum chymotrytic enzyme mRNA in said sample compared to normal ovarian tissue sample is indicative of the presence of malignant ovarian hyperplasia.
- 2. The method of claim 1, wherein said detection of said stratum corneum chymotrytic enzyme mRNA is by PCR amplification.
- 3. The method of claim 2, wherein said PCR amplification uses primers selected from the group consisting of SEQ ID No. 10 and SEQ ID No. 11.
- 4. The method of claim 1, wherein said biological sample is selected from the group consisting of blood, interstitial fluid, ascites fluid, tumor tissue biopsy and circulating tumor cells.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of U.S. Ser. No. 09/905,083, filed Jul. 13, 2001, which is a divisional application of U.S. Ser. No. 09/502,600, filed Feb. 11, 2000, now U.S. Pat. No. 6,294,344 which is a continuation-in-part application of U.S. Ser. No. 09/039,211, filed Mar. 14, 1998, now U.S. Pat. No. 6,303,318 which claims benefit of provisional patent application U.S. Ser. No. 60/041,404, filed Mar. 19, 1997, now abandoned.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
5981256 |
Egelrud |
Nov 1999 |
A |
Non-Patent Literature Citations (1)
Entry |
Yousef. Gene (Aug. 2000) 254: 119-128. |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/041404 |
Mar 1997 |
US |
Continuation in Parts (2)
|
Number |
Date |
Country |
Parent |
09/905083 |
Jul 2001 |
US |
Child |
09/918243 |
|
US |
Parent |
09/039211 |
Mar 1998 |
US |
Child |
09/502600 |
|
US |