Claims
- 1. A method of treating cardiac arrhythmia in mammals comprising block of the slowly activating delayed rectifier potassium (K+) current (IK.sub.s) and the rapidly activating and deactivating delayed rectifier potassium current (IK.sub.r), wherein the slowly activating delayed rectifier potassium (K.sup.+) current (IK.sub.s) in isolated myocytes is selectively blocked by a compound at a concentration of 1 .mu.M or less (IC.sub.50) and the concentration that blocks IKs by 50% is at least 10 fold lower than the concentration required to cause 50% block of IK.sub.r and or IK.sub.1.
CROSS REFERENCE
This is a continuation of application Ser. No. 08/156,184 filed Nov. 22, 1993, now U.S. Pat. No. 5,428,031, which is a continuation in part of U.S. patent application Ser. No. 08/018,912 which was filed on Feb. 17, 1993, now abandoned, which is a continuation of U.S. patent application Ser. No. 07/802,000 which was filed on Dec. 3, 1991, now abandoned.
US Referenced Citations (10)
Foreign Referenced Citations (4)
Number |
Date |
Country |
1190708 |
Jul 1985 |
CAX |
0538945A1 |
Apr 1993 |
EPX |
0107095 |
May 1994 |
EPX |
9315068 |
Jan 1993 |
JPX |
Non-Patent Literature Citations (2)
Entry |
J. Gen. Physiol., vol. 96, Jul. 1990, pp. 195-215, by M. C. Sanguinetti, et al. |
J. Cardiovascular Pharmacology, vol. 20 (Suppl. 2), pp. S17-S22 (1992), by L. M. Hondeghem. |
Continuations (2)
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Number |
Date |
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Parent |
156184 |
Nov 1993 |
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Parent |
802000 |
Dec 1991 |
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Continuation in Parts (1)
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Number |
Date |
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Parent |
18912 |
Feb 1993 |
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